id	category	name	description	xref	provided_by	synonym	iri	same_as	subsets
HP:0011770	biolink:PhenotypicFeature	Tertiary hyperparathyroidism	A type of hyperparathyroidism that occurs following kidney transplantation, which is a treatment for secondary hyperparathyroidism. Although kidney transplantation leads to a normalization of serum calcium and parathyroid hormone in most patients. The state of persistent hypercalcemia and hyperparathyroidism is referred to as tertiary hyperparathyroidism.	SNOMEDCT_US:78200003|UMLS:C0271858	hp.json		http://purl.obolibrary.org/obo/HP_0011770		
HP:0011771	biolink:PhenotypicFeature	Autoimmune hypoparathyroidism	A type of hypoparathyroidism with circulating antiparathyroid or anti-calcium sensing receptor antibodies indicative of autoimmunity.	UMLS:C0271865|SNOMEDCT_US:75316000	hp.json		http://purl.obolibrary.org/obo/HP_0011771		
HP:0011772	biolink:PhenotypicFeature	Abnormal thyroid morphology	A structural abnormality of the thyroid gland.	UMLS:C4023195	hp.json	Abnormal shape of thyroid gland|Abnormality of thyroid morphology	http://purl.obolibrary.org/obo/HP_0011772		
UBERON:0011591	biolink:AnatomicalEntity	tract of diencephalon	An axon tract that is part of a diencephalon.	FMA:62447	hp.json	diencephalon tract	http://purl.obolibrary.org/obo/UBERON_0011591		
HP:0011773	biolink:PhenotypicFeature	Uninodular goiter	Enlargement of the thyroid gland related to a singular nodule in the thyroid gland.	UMLS:C0342205|SNOMEDCT_US:237569006	hp.json	Uninodular goitre	http://purl.obolibrary.org/obo/HP_0011773		
UBERON:0011590	biolink:AnatomicalEntity	commissure of diencephalon	A commissure that is part of a diencephalon.	FMA:62445	hp.json	diencephalon commissure	http://purl.obolibrary.org/obo/UBERON_0011590		
HP:0011774	biolink:PhenotypicFeature	Thyroid follicular adenoma		SNOMEDCT_US:255034006|MSH:D013964|UMLS:C0151468|SNOMEDCT_US:255033000	hp.json		http://purl.obolibrary.org/obo/HP_0011774		
HP:0011775	biolink:PhenotypicFeature	Thyroid macrofollicular adenoma		UMLS:C4023194	hp.json		http://purl.obolibrary.org/obo/HP_0011775		
HP:0011776	biolink:PhenotypicFeature	Thyroid microfollicular adenoma		UMLS:C4023193	hp.json		http://purl.obolibrary.org/obo/HP_0011776		
UBERON:0011595	biolink:AnatomicalEntity	jaw region	A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions.	NCIT:C114916|EMAPA:32905	hp.json		http://purl.obolibrary.org/obo/UBERON_0011595		
UBERON:0011594	biolink:AnatomicalEntity	dentary tooth	Tooth that is attached to a dentary/mandible[TAO,modified].	AAO:0000125|AAO:0000641|FMA:321647|TAO:0001628	hp.json	tooth of dentary|mandibular teeth|mandibular tooth	http://purl.obolibrary.org/obo/UBERON_0011594		
UBERON:0011593	biolink:AnatomicalEntity	maxillary tooth	A tooth that is attached to a maxilla[TAO,modified].	AAO:0000287|FMA:321646|TAO:0001627	hp.json	maxillary teeth	http://purl.obolibrary.org/obo/UBERON_0011593		
UBERON:0011592	biolink:AnatomicalEntity	future upper lip		EHDAA2:0002120	hp.json	upper jaw future lip	http://purl.obolibrary.org/obo/UBERON_0011592		
UBERON:0011597	biolink:AnatomicalEntity	bone of upper jaw	Any bone that is part of the upper jaw skeleton. This includes (when present): the maxilla, the quadrate (in some species).		hp.json	upper jaw bone	http://purl.obolibrary.org/obo/UBERON_0011597		grouping_class
UBERON:0011596	biolink:AnatomicalEntity	future lower lip		EHDAA2:0001020	hp.json	lower jaw future lip	http://purl.obolibrary.org/obo/UBERON_0011596		
UBERON:0011589	biolink:AnatomicalEntity	non-mineralized cartilage tissue	Cartilage tissue that is not mineralized.	XAO:0004044|VSAO:0000089	hp.json		http://purl.obolibrary.org/obo/UBERON_0011589		
HP:0008117	biolink:PhenotypicFeature	Shortening of the talar neck		UMLS:C1843985	hp.json		http://purl.obolibrary.org/obo/HP_0008117		
HP:0008119	biolink:PhenotypicFeature	Deformed tarsal bones		UMLS:C1856746	hp.json	Deformed ankle bones	http://purl.obolibrary.org/obo/HP_0008119		
HP:0011777	biolink:PhenotypicFeature	Thyroid papillary adenoma		UMLS:C4023192	hp.json		http://purl.obolibrary.org/obo/HP_0011777		
HP:0008114	biolink:PhenotypicFeature	Metatarsal diaphyseal endosteal sclerosis	Osteosclerosis of the endosteal surface of the diaphyses (shafts) of the metatarsal bones.	UMLS:C1840420	hp.json		http://purl.obolibrary.org/obo/HP_0008114		
HP:0011778	biolink:PhenotypicFeature	Thyroid atypical adenoma		UMLS:C4023191	hp.json		http://purl.obolibrary.org/obo/HP_0011778		
HP:0008113	biolink:PhenotypicFeature	Multiple plantar creases		UMLS:C1861873	hp.json		http://purl.obolibrary.org/obo/HP_0008113		
HP:0008116	biolink:PhenotypicFeature	Flexion limitation of toes	Limitation of the ability to bend the toes.	UMLS:C4024731	hp.json		http://purl.obolibrary.org/obo/HP_0008116		
HP:0011779	biolink:PhenotypicFeature	Anaplastic thyroid carcinoma		MSH:D065646|SNOMEDCT_US:255031003|UMLS:C0238461	hp.json		http://purl.obolibrary.org/obo/HP_0011779		
HP:0008115	biolink:PhenotypicFeature	Clinodactyly of the 3rd toe	Bending or curvature of a third toe in the tibial direction (i.e., towards the big toe).	UMLS:C4280416|UMLS:C4021555	hp.json	3rd toe clinodactyly|Curvature of 3rd toe	http://purl.obolibrary.org/obo/HP_0008115		
HP:0008110	biolink:PhenotypicFeature	Equinovarus deformity		MSH:D003025|UMLS:C0009081|SNOMEDCT_US:397932003|SNOMEDCT_US:249808002	hp.json		http://purl.obolibrary.org/obo/HP_0008110		
HP:0008112	biolink:PhenotypicFeature	Plantar flexion contractures		UMLS:C1861239	hp.json		http://purl.obolibrary.org/obo/HP_0008112		
HP:0008111	biolink:PhenotypicFeature	Broad distal hallux		UMLS:C1863403	hp.json	Broad distal big toe	http://purl.obolibrary.org/obo/HP_0008111		
HP:0011760	biolink:PhenotypicFeature	Pituitary growth hormone cell adenoma	A type of pituitary adenoma that produces growth hormone.	UMLS:C4018860	hp.json	Pituitary somatotropinoma	http://purl.obolibrary.org/obo/HP_0011760		
HP:0011761	biolink:PhenotypicFeature	Pituitary null cell adenoma	A type of pituitary adenoma that is of unknown cellular origin and that lacks immunocytochemical or fine structural markers. Null cell adenomas are not associated with hormone excess.	UMLS:C0338078|SNOMEDCT_US:254962005	hp.json	Hormonally silent pituitary adenoma|Silent pituitary adenoma|Clinically silent pituitary adenoma|Non-functional pituitary adenoma	http://purl.obolibrary.org/obo/HP_0011761		
HP:0011762	biolink:PhenotypicFeature	Pituitary thyrotropic cell adenoma	A type of pituitary adenoma that produces thyroid stimulating hormone (TSH).	UMLS:C4021121	hp.json	Pituitary thyrotropinoma	http://purl.obolibrary.org/obo/HP_0011762		
HP:0011763	biolink:PhenotypicFeature	Pituitary carcinoma	A pituitary tumor with subarachnoid, brain, or systemic metastasis. The diagnosis of a pituitary carcinoma requires evidence of metastatic disease, either outside the central nervous system (CNS) or as separate noncontiguous foci within the CNS.	MSH:D010911|UMLS:C0346300|SNOMEDCT_US:254955001|SNOMEDCT_US:128665000	hp.json		http://purl.obolibrary.org/obo/HP_0011763		
HP:0011764	biolink:PhenotypicFeature	Pituitary spindle cell oncocytoma	A spindled-to-epithelioid, oncocytic, nonendocrine neoplasm of the anterior hypophysis that manifests in adults and follows a benign clinical course. Pituitary spindle cell oncocytomas are firm, fibrous, and adherent to surrounding structures and are highly vascular.	UMLS:C4023200	hp.json		http://purl.obolibrary.org/obo/HP_0011764		
HP:0011765	biolink:PhenotypicFeature	obsolete Ectopic anterior pituitary			hp.json		http://purl.obolibrary.org/obo/HP_0011765		
UBERON:0011584	biolink:AnatomicalEntity	zeugopodial skeleton	Section of the forelimb skeleton located between the stylopodium and the autopodium.	VSAO:0005010	hp.json	epipodium|mesomere 2|zygopodium|zeugopod skeleton|skeleton of zeugopod|mesomere 2 skeleton|epipodial skeleton	http://purl.obolibrary.org/obo/UBERON_0011584		
UBERON:0011583	biolink:AnatomicalEntity	stylopodial skeleton	Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified].	VSAO:0005007	hp.json	propodial skeleton|proximal metapterygial mesomere|stylopodium skeleton|mesomere 1|stylopod|propodium|stylopodium	http://purl.obolibrary.org/obo/UBERON_0011583		
UBERON:0011582	biolink:AnatomicalEntity	paired limb/fin skeleton	The collection of all skeletal elements in an individual limb or fin.	VSAO:0000301	hp.json	limb/fin skeleton|skeleton of limb/fin|skeletal parts of limb/fin	http://purl.obolibrary.org/obo/UBERON_0011582		homology_grouping
UBERON:0011588	biolink:AnatomicalEntity	pre-enamel	Odontogenic tissue that is avascular non-mineralized matrix that is deposited by preameloblast and ameloblasts that are excluded from the matrix.	XAO:0004202|VSAO:0000066	hp.json	preenamel tissue|pre-enamel tissue	http://purl.obolibrary.org/obo/UBERON_0011588		
UBERON:0011587	biolink:AnatomicalEntity	pre-dentine	Odontogenic tissue that is collagen-rich and characteristic of vertebrate teeth and tooth-like structures (e.g., odontodes) deposited by preodontoblasts and odontoblasts that are typically excluded from the matrix.	VSAO:0000071|EMAPA:36439|XAO:0004052	hp.json	predentin|predentine tissue|pre-dentine tissue	http://purl.obolibrary.org/obo/UBERON_0011587		
UBERON:0011585	biolink:AnatomicalEntity	cell condensation	Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995).	XAO:0004021|VSAO:0000006	hp.json		http://purl.obolibrary.org/obo/UBERON_0011585		
HP:0011766	biolink:PhenotypicFeature	Abnormality of the parathyroid morphology	A structural abnormality of the parathyroid gland.	UMLS:C4023199	hp.json		http://purl.obolibrary.org/obo/HP_0011766		
HP:0008125	biolink:PhenotypicFeature	Second metatarsal posteriorly placed		UMLS:C1859224	hp.json		http://purl.obolibrary.org/obo/HP_0008125		
HP:0011767	biolink:PhenotypicFeature	Abnormality of the parathyroid physiology	A functional abnormality of the parathyroid gland.	UMLS:C4023198	hp.json	Parathyroid dysfunction|Parathyroid issue	http://purl.obolibrary.org/obo/HP_0011767		
HP:0008124	biolink:PhenotypicFeature	Talipes calcaneovarus	A congenital deformity characterized by a dorsiflexed, inverted, and adducted foot, i.e., a combination of talipes calcaneus and talipes varus.	SNOMEDCT_US:30449003|MSH:D000070558|UMLS:C0265646	hp.json		http://purl.obolibrary.org/obo/HP_0008124		
HP:0011768	biolink:PhenotypicFeature	Parathyroid dysgenesis	Abnormal embryonic development of the parathyroid gland.	UMLS:C4023197	hp.json		http://purl.obolibrary.org/obo/HP_0011768		
HP:0008127	biolink:PhenotypicFeature	Bipartite calcaneus	A two-part calcaneus, a finding that probably results from delayed coalescence of two primary calcaneal centers of ossification.	UMLS:C1835574	hp.json	Delayed coalescence of calcaneal ossification centres|Double calcaneal ossification centre|Delayed coalescence of bipartite calcanei|Extra calcaneal ossification centre|Double calcaneal ossification center|Extra calcaneal ossification center|Delayed coalescence of calcaneal ossification centers|Delayed fusion of bipartite calcanei	http://purl.obolibrary.org/obo/HP_0008127		
HP:0011769	biolink:PhenotypicFeature	Ectopic parathyroid	An abnormal anatomical location of the parathyroid gland.	UMLS:C4023196	hp.json		http://purl.obolibrary.org/obo/HP_0011769		
HP:0008122	biolink:PhenotypicFeature	Calcaneonavicular fusion	Synostosis of the calcaneus with the navicular bone.	UMLS:C4024730	hp.json		http://purl.obolibrary.org/obo/HP_0008122		
HP:0011750	biolink:PhenotypicFeature	Neoplasm of the anterior pituitary	A tumor (abnormal growth of tissue) of the adenohypophysis, which is also known as the anterior lobe of the pituitary gland.	NCIT:C3262|UMLS:C4023205	hp.json	Neoplasm of the adenohypophysis|Neoplasm of the pars anterior	http://purl.obolibrary.org/obo/HP_0011750		
HP:0011751	biolink:PhenotypicFeature	Abnormality of the posterior pituitary	An abnormality of the neurohypophysis, which is also known as the posterior lobe of the hypophysis.	UMLS:C4023204	hp.json	Abnormality of the neurohypophysis	http://purl.obolibrary.org/obo/HP_0011751		
HP:0011752	biolink:PhenotypicFeature	Neoplasm of the posterior pituitary	The presence of a neoplasm (tumour) in the neurohypophysis, which is also known as the posterior lobe of the hypophysis.	NCIT:C3262|UMLS:C1334957	hp.json	Neoplasm of the neurohypophysis	http://purl.obolibrary.org/obo/HP_0011752		
HP:0011753	biolink:PhenotypicFeature	Posterior pituitary dysgenesis	Abnormal development of the neurohypophysis during embryonic growth and development.	UMLS:C4021123	hp.json	Posterior pituitary dysplasia|Neurohypophysis dysplasia	http://purl.obolibrary.org/obo/HP_0011753		
HP:0011754	biolink:PhenotypicFeature	Pituicytoma	A solid, low grade, spindle cell, glial neoplasm of adults that originates in the neurohypophysis or infundibulum. Clinical signs and symptoms include visual disturbance, headache and features of hypopituitarism. Pituicytomas are well-circumscribed, solid masses that can measure up to several centimeters. Histologically, they show a compact architecture consisting of elongate, bipolar spindle cells arranged in interlacing fascicles or assuming a storiform pattern.	SNOMEDCT_US:450901008|UMLS:C2986550|ICD-O:9432/1|SNOMEDCT_US:608817003	hp.json		http://purl.obolibrary.org/obo/HP_0011754		
HP:0033103	biolink:PhenotypicFeature	Elevated circulating CHI3L1 level	Increased concentration of chitinase 3-like 1 (CHI3L1) in the blood circulation.		hp.json	Elevated circulating YKL40 level|Elevated circulating chitinase 3-like 1 level	http://purl.obolibrary.org/obo/HP_0033103		
HP:0033102	biolink:PhenotypicFeature	Monkey wrench femoral neck	The femoral neck region shows medial metaphyseal beaking and a significant enlargement of the lesser trochanter (with some enlargement also of the greater trochanter), producing a monkey wrench (Swedish key) configuration of the proximal femur. A monkey wrench refers to a type of adjustable wrench with one fixed and one adjustable jaw at right angles to a straight handle.		hp.json	Swedish key appearance of femoral neck|Swedish key configuration of the proximal femur|Monkey wrench appearance of femoral neck|Monkey wrench configuration of the proximal femur	http://purl.obolibrary.org/obo/HP_0033102		
HP:0033105	biolink:PhenotypicFeature	Interhypothalamic Adhesion	An abnormal parenchymal band connecting the medial margins of the left and right hypothalami across the third ventricle.		hp.json	Hypothalamic adhesion	http://purl.obolibrary.org/obo/HP_0033105		
HP:0033104	biolink:PhenotypicFeature	Inappropriate absence of fever	Failure to develop fever in the presence of an infection that normally would be expected to elicit a febrile response.		hp.json		http://purl.obolibrary.org/obo/HP_0033104		
UBERON:0011576	biolink:AnatomicalEntity	supraorbital ridge	The superior half of the orbital rim, which constitutes the curved superior border of the orbital opening, formed by the frontal bone.	FMA:317104|UMLS:C2826587|NCIT:C82953	hp.json	supraorbital arch|supra-orbital ridge|supraorbital torus|supra-orbital margin of frontal bone|supra-orbital margin|eyebrow bone|margo supraorbitalis (os frontale)|supra-orbital border of frontal bone|supraorbital margin of frontal bone|superior orbital rim|orbital ridge|frontal torus|supraorbital margin|supraorbital surface of frontal bone|frontal torus|superciliary ridge|supraorbital torus|margin of the orbit|supraorbital margin|arcus superciliaris|margo supraorbitalis	http://purl.obolibrary.org/obo/UBERON_0011576		pheno_slim
HP:0033101	biolink:PhenotypicFeature	Elevated urine aconitic acid level	An abnormally increased level of aconitic acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033101		
UBERON:0011575	biolink:AnatomicalEntity	styloid process of ulna	The styloid process of the ulna projects from the medial and back part of the bone; it descends a little lower than the head, and its rounded end affords attachment to the ulnar collateral ligament of the wrist[WP,unvetted].	FMA:23628	hp.json	processus styloideus ulnae|processus styloideus ulnae|ulnar styloid process	http://purl.obolibrary.org/obo/UBERON_0011575		pheno_slim
UBERON:0011574	biolink:AnatomicalEntity	mesonephric duct lumen	A tube lumen that is part of a mesonephric duct.	EHDAA2:0001244	hp.json	cavity of nephric duct|nephric duct lumen	http://purl.obolibrary.org/obo/UBERON_0011574		
HP:0033100	biolink:PhenotypicFeature	Increased proteinogenic amino acid level in urine	An elevated level of a proteinogenic amino acid in the urine. These are the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine.		hp.json		http://purl.obolibrary.org/obo/HP_0033100		
HP:0033107	biolink:PhenotypicFeature	Abnormal circulating proteinogenic amino acid concentration	An elevated level of a proteinogenic amino acid in the blood circulation. These are the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine.		hp.json		http://purl.obolibrary.org/obo/HP_0033107		
HP:0033106	biolink:PhenotypicFeature	Elevated circulating D-dimer concentration	An increased concentration of D-dimers, a marker of fibrin degradation, in the blood circulation.		hp.json	Elevated D-dimers|Elevated fibrin degradation fragment concentration	http://purl.obolibrary.org/obo/HP_0033106		
HP:0033109	biolink:PhenotypicFeature	Abnormal circulating non-proteinogenic amino acid concentration	Any deviation from the normal concentration in the blood circulation of an alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.		hp.json		http://purl.obolibrary.org/obo/HP_0033109		
HP:0033108	biolink:PhenotypicFeature	Abnormal circulating proteinogenic amino acid derivative concentration	Any deviation from the normal concentration in the blood circulation of a compound that is derived from an amino acid.		hp.json		http://purl.obolibrary.org/obo/HP_0033108		
HP:0011755	biolink:PhenotypicFeature	Ectopic posterior pituitary	An abnormal anatomical location of the posterior lobe of the hypophysis, also known as the neurohypophysis. The posterior pituitary is normally present in the dorsal portion of the sella turcica, but when ectopic is usually near the median eminence. This defect is likely to be due to abnormal migration during embryogenesis.	UMLS:C3279571|UMLS:C4053775|SNOMEDCT_US:715727009	hp.json	Ectopic neurohypophysis	http://purl.obolibrary.org/obo/HP_0011755		
HP:0011756	biolink:PhenotypicFeature	Posterior pituitary agenesis	Absence of the neurohypophysis owing to a developmental defect.	UMLS:C4023203	hp.json	Neurohypophysis agenesis	http://purl.obolibrary.org/obo/HP_0011756		
HP:0011757	biolink:PhenotypicFeature	Posterior pituitary hypoplasia	Underdevelopment of the neurohypophysis.	UMLS:C4023202	hp.json	Neurohypophysis hypoplasia	http://purl.obolibrary.org/obo/HP_0011757		
HP:0011758	biolink:PhenotypicFeature	Pituitary acidophilic stem cell adenoma		UMLS:C4023201	hp.json		http://purl.obolibrary.org/obo/HP_0011758		
HP:0011759	biolink:PhenotypicFeature	Pituitary gonadotropic cell adenoma	A type of pituitary adenoma that produces gonadotropins.	UMLS:C4021122	hp.json	Pituitary gonadotropinoma	http://purl.obolibrary.org/obo/HP_0011759		
CHEBI:26537	biolink:ChemicalSubstance	retinoid	Oxygenated derivatives of 3,7-dimethyl-1-(2,6,6-trimethylcyclohex-1-enyl)nona-1,3,5,7-tetraene and derivatives thereof.		hp.json	retinoids|retinoid|retinoids	http://purl.obolibrary.org/obo/CHEBI_26537		3_STAR
HP:0011740	biolink:PhenotypicFeature	Glucocortocoid-insensitive primary hyperaldosteronism	A form of primary hyperaldosteronism in which the overproduction of aldosterone cannot be suppressed by the administration of dexamethasone or similar glucocorticoids.	UMLS:C4023208|UMLS:C4020742	hp.json	Familial primary hyperaldosteronism type 2	http://purl.obolibrary.org/obo/HP_0011740		
HP:0011741	biolink:PhenotypicFeature	Secondary hyperaldosteronism	A form of hyperaldosteronism caused by abnormally increased renin levels.	SNOMEDCT_US:67805000|UMLS:C0271728	hp.json	Hyperreninemic hyperaldosteronism	http://purl.obolibrary.org/obo/HP_0011741		
HP:0011742	biolink:PhenotypicFeature	Ectopic adrenal gland	Abnormal anatomical location of the adrenal gland.	UMLS:C0266275|SNOMEDCT_US:49494003	hp.json	Abnormal adrenal gland position	http://purl.obolibrary.org/obo/HP_0011742		
HP:0011743	biolink:PhenotypicFeature	Adrenal gland agenesis	Absent development of the adrenal gland.	MSH:C538429|UMLS:C0266273|SNOMEDCT_US:83190008|SNOMEDCT_US:702615004	hp.json		http://purl.obolibrary.org/obo/HP_0011743		
HP:0033114	biolink:PhenotypicFeature	Quadruple gallop rhythm	A type of gallop rhytm in which both the third and the fourth sounds are present.		hp.json		http://purl.obolibrary.org/obo/HP_0033114		
HP:0033113	biolink:PhenotypicFeature	Gallop rhythm	In the normal heart cycle, two heart sounds can be heard by auscultation per cycle: S1 and S2. A gallop rhythm refers to the presence of three or four heart sounds per cardiac cycle, which is said to resemble the gallop of a horse.		hp.json	Triple rhythm	http://purl.obolibrary.org/obo/HP_0033113		
UBERON:0035597	biolink:AnatomicalEntity	profundal placode	An embryonic structure positioned halfway between the prospective eye and ear, adjacent to the future midbrain-hindbrain boundary. The profundal and the trigeminal ganglia are separate distally but fused at their proximal end as they condense around NF stage 24.	XAO:0004093	hp.json	ophthalmic placode|profundus placode|ophthalmic lobe of trigeminal placode complex|ophthalmic lobe of trigeminal placode	http://purl.obolibrary.org/obo/UBERON_0035597		
HP:0033116	biolink:PhenotypicFeature	Duodenal gastric metaplasia	Foci of gastric-type mucus-secreting cells interspersed between duodenal enterocytes. These foci of gastric epithelial cells contain Periodic acid-Schiff (PAS)-positive neutral mucin and lack a brush border.		hp.json		http://purl.obolibrary.org/obo/HP_0033116		
HP:0033115	biolink:PhenotypicFeature	Elevated circulating tenascin-C level	Abnormally increased concentration of tenascin-C in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033115		
UBERON:0011566	biolink:AnatomicalEntity	lumen of esophagus	An anatomical cavity that is part of a esophagus.	SCTID:322648002|FMA:9398|EMAPA:18380	hp.json	esophagus lumen|cavity of eosophagus|eosophagus lumen|esophageal cavity|eosophageal cavity|eosophageal lumen|esophageal lumen|cavity of esophagus	http://purl.obolibrary.org/obo/UBERON_0011566		pheno_slim
HP:0033110	biolink:PhenotypicFeature	Elevated circulating alpha-aminobutyric acid concentration	An abnormally increased level of alpa-aminobutyric acid in the blood circulation. Alpha-aminobutyric acid alpha-amino acid that is butyric acid bearing a single amino substituent located at position 2.		hp.json	Elevated circulating homoalanine concentration	http://purl.obolibrary.org/obo/HP_0033110		
UBERON:0011565	biolink:AnatomicalEntity	lumen of gastrointestinal system		SCTID:432899004|FMA:54364	hp.json	cavity of gastrointestinal tract|gastrointestinal tract lumen|cavity of digestive tract|lumen of gastrointestinal tract	http://purl.obolibrary.org/obo/UBERON_0011565		
HP:0033112	biolink:PhenotypicFeature	Elevated circulating apolipoprotein C-III concentration	An increased concentration in blood of apolipoprotein C-III, a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons.		hp.json	Elevated apolipoprotein C-III level|Elevated APOC3 level	http://purl.obolibrary.org/obo/HP_0033112		
HP:0033111	biolink:PhenotypicFeature	3-hydroxyisovaleric aciduria	Concentration of 3-hydroxyisovaleric acid in the urine above the normal range.		hp.json	Increased urine 3-hydroxyisovaleric acid level	http://purl.obolibrary.org/obo/HP_0033111		
HP:0008107	biolink:PhenotypicFeature	Plantar crease between first and second toes	The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot located between the first and second toe.	UMLS:C1867132	hp.json		http://purl.obolibrary.org/obo/HP_0008107		
HP:0033118	biolink:PhenotypicFeature	Abnormal right ventricular function	Anomalous physiology (function) of the right ventricle.		hp.json		http://purl.obolibrary.org/obo/HP_0033118		
HP:0033117	biolink:PhenotypicFeature	Duodenitis	Inflammation of the lining of the upper small intestine (duodenum).		hp.json		http://purl.obolibrary.org/obo/HP_0033117		
HP:0008108	biolink:PhenotypicFeature	Advanced tarsal ossification	Precocious (accelerated) maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.	UMLS:C4280417|UMLS:C1849293	hp.json	Precociously ossified tarsal bones|Accelerated ankle bone maturation	http://purl.obolibrary.org/obo/HP_0008108		
HP:0033119	biolink:PhenotypicFeature	Elevated right ventricular systolic pressure	Elevation of right ventricular systolic pressure (RVSP) above normal limits. In adults, RVSP is normally 20-30 mmHg.		hp.json		http://purl.obolibrary.org/obo/HP_0033119		
HP:0011744	biolink:PhenotypicFeature	Secondary hypercortisolism	Hypercortisolemia associated with a overproduction of ACTH (often from a tumor), leading secondarily to overproduction of cortisol.	UMLS:C4023207|UMLS:C4020741	hp.json	ACTH-dependent hypercortisolemia	http://purl.obolibrary.org/obo/HP_0011744		
HP:0008103	biolink:PhenotypicFeature	Delayed tarsal ossification	Delayed maturation and calcification of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.	UMLS:C4280418|UMLS:C1846853	hp.json	Delayed ankle bone maturation|Tarsal delayed ossification	http://purl.obolibrary.org/obo/HP_0008103		
HP:0011745	biolink:PhenotypicFeature	Non-secretory adrenocortical adenoma	An hormonally inactive adrenocortical adenoma, that is, an adenoma that does not secrete excessive amounts of adrenal hormones.	UMLS:C4021126	hp.json	Non-secretory adrenal adenoma	http://purl.obolibrary.org/obo/HP_0011745		
HP:0008102	biolink:PhenotypicFeature	Expanded metatarsals with widened medullary cavities		UMLS:C1969289	hp.json		http://purl.obolibrary.org/obo/HP_0008102		
HP:0011746	biolink:PhenotypicFeature	Secretory adrenocortical adenoma	An hormonally active adrenocortical adenoma, that is, an adenoma that secretes excessive amounts of adrenal hormones.	UMLS:C4021125	hp.json	Secretory adrenal adenoma	http://purl.obolibrary.org/obo/HP_0011746		
HP:0011747	biolink:PhenotypicFeature	Abnormality of the anterior pituitary	An abnormality of the adenohypophysis, which is also known as the anterior lobe of the pituitary gland.	SNOMEDCT_US:399244003|UMLS:C0032002|MSH:D010900|UMLS:C4023206	hp.json	Pituitary disease	http://purl.obolibrary.org/obo/HP_0011747		
HP:0011748	biolink:PhenotypicFeature	Adrenocorticotropic hormone deficiency	A reduced ability to secrete adrenocorticotropic hormone (ACTH), a hormone that stimulates the adrenal cortex to secrete of glucocorticoids such as cortisol.	MSH:C535668|UMLS:C0342388|SNOMEDCT_US:237692001	hp.json	Corticotropin deficiency|ACTH deficiency	http://purl.obolibrary.org/obo/HP_0011748		
HP:0011749	biolink:PhenotypicFeature	Adrenocorticotropic hormone excess	Overproduction of adrenocorticotropic hormone (ACTH), which generally leads secondarily to overproduction of cortisol by the adrenal cortex.	UMLS:C4021124	hp.json	ACTH excess	http://purl.obolibrary.org/obo/HP_0011749		
HP:0008161	biolink:PhenotypicFeature	Absent leukocyte alkaline phosphatase	Alkaline phosphatase levels measured within leukocytes is below detectable levels.	UMLS:C4024724	hp.json	Absent leukocyte ALP	http://purl.obolibrary.org/obo/HP_0008161		
HP:0008160	biolink:PhenotypicFeature	3-hydroxydicarboxylic aciduria	An increase in the level of 3-hydroxydicarboxylic acid in the urine.	UMLS:C4024725	hp.json		http://purl.obolibrary.org/obo/HP_0008160		
HP:0008163	biolink:PhenotypicFeature	Decreased circulating cortisol level	Abnormally reduced concentration of cortisol in the blood.	UMLS:C1836623|UMLS:C1846225|UMLS:C1833054	hp.json	Low blood cortisol level|Plasma cortisol low|Hypocortisolemia|Low to undetectable plasma cortisol|Glucocorticoid insufficiency|Decreased cortisol production|Hypocortisolism	http://purl.obolibrary.org/obo/HP_0008163		
HP:0008162	biolink:PhenotypicFeature	Asymptomatic hyperammonemia	An increased concentration of ammonia in the blood not associated with symptoms such as encephalopathy.	UMLS:C4021552	hp.json	Hyperammonemia, asymptomatic	http://purl.obolibrary.org/obo/HP_0008162		
PR:P17679	biolink:Protein	erythroid transcription factor (mouse)	An erythroid transcription factor that is encoded in the genome of mouse.	UniProtKB:P17679	hp.json	GATA-1 (mouse)|Gata1|Eryf1 (mouse)|GF-1 (mouse)|NF-E1 DNA-binding protein (mouse)|Gf-1|GATA-binding factor 1 (mouse)|mGATA1	http://purl.obolibrary.org/obo/PR_P17679		
UBERON:0035523	biolink:AnatomicalEntity	anterior surface of prostate	The aspect of the prostate facing the pubic symphysis.	NCIT:C13089|FMA:19591	hp.json	facies anterior (prostatae)|facies anterior prostatae|anterior surface of prostate gland	http://purl.obolibrary.org/obo/UBERON_0035523		
CHEBI:63534	biolink:ChemicalSubstance	monoamine	An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.	PMID:22371656|PMID:22213370|PMID:22082101|PMID:22342987|PMID:22153577|PMID:21993877|PMID:21822758|PMID:22005599|PMID:22218931	hp.json	naturally occurring monoamines|naturally occurring monoamine|monoamines	http://purl.obolibrary.org/obo/CHEBI_63534		3_STAR
CHEBI:63533	biolink:ChemicalSubstance	gonadotropin releasing hormone agonist	Any drug which binds to gonadotropin-releasing hormone receptors and triggers a response.	Wikipedia:Gonadotropin-releasing_hormone_agonist	hp.json	gonadotrophin releasing hormone agonists|gonadotropin releasing hormone agonists|gonadotrophin releasing hormone agonist|GnRH agonist|GnRH agonists|GnRH-A	http://purl.obolibrary.org/obo/CHEBI_63533		3_STAR
HP:0008158	biolink:PhenotypicFeature	Hyperapobetalipoproteinemia	Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein.	MSH:D006950|SNOMEDCT_US:299465007|SNOMEDCT_US:238040008|UMLS:C0020474	hp.json		http://purl.obolibrary.org/obo/HP_0008158		
HP:0008153	biolink:PhenotypicFeature	Periodic hypokalemic paresis	Episodes of muscle weakness associated with reduced levels of potassium in the blood.	UMLS:C4021553	hp.json	Hypokalemic periodic paresis	http://purl.obolibrary.org/obo/HP_0008153		
HP:0008155	biolink:PhenotypicFeature	Mucopolysacchariduria	Excessive amounts of mucopolysaccharide in the urine.	UMLS:C4024726	hp.json		http://purl.obolibrary.org/obo/HP_0008155		
UBERON:0035529	biolink:AnatomicalEntity	left common iliac artery		FMA:14766|NCIT:C32957	hp.json	trunk of left common iliac arterial tree	http://purl.obolibrary.org/obo/UBERON_0035529		human_reference_atlas
HP:0008169	biolink:PhenotypicFeature	Reduced factor VII activity	Reduced activity of coagulation factor VII. Factor VII is part of the extrinsic coagulation pathway, which is initiated at the site of injury in response to the release of tissue factor (fIII). Tissue factor and activated factor VII catalyze the activation of factor X.	SNOMEDCT_US:37193007|UMLS:C4024722|UMLS:C0015503|MSH:D005168	hp.json	Factor VII deficiency	http://purl.obolibrary.org/obo/HP_0008169		
HP:0008165	biolink:PhenotypicFeature	Decreased helper T cell proportion	Reduced proportion of helper T cells relative to the total number of T cells.	UMLS:C4024723	hp.json	Decreased proportion circulating T-helper cells|Reduced helper T cell proportion	http://purl.obolibrary.org/obo/HP_0008165		
HP:0008167	biolink:PhenotypicFeature	Very long chain fatty acid accumulation		UMLS:C3279397	hp.json		http://purl.obolibrary.org/obo/HP_0008167		
HP:0008166	biolink:PhenotypicFeature	Decreased beta-galactosidase activity	Abnormally decreased rate of beta-galactosidase activity. Beta-galactosidase activity can be measured in leukocyte, fibroblast, or plasma.	SNOMEDCT_US:238025006|MSH:D016537|UMLS:C0085131|UMLS:C1856559|UMLS:C1854788	hp.json	Beta-galactosidase deficiency in fibroblasts and white blood cells|Decreased beta galactosidase activity|Beta-galactosidase-1 deficiency	http://purl.obolibrary.org/obo/HP_0008166		
HP:0011791	biolink:PhenotypicFeature	Inactivating thyroid-stimulating hormone receptor defect	Loss-of-function thyroid-stimulating hormone receptor (TSHR) defect.	UMLS:C4023187	hp.json	Inactivating TSHR defect	http://purl.obolibrary.org/obo/HP_0011791		
HP:0011792	biolink:PhenotypicFeature	Neoplasm by histology	Neoplasm categorized according to type of histological abnormality.	UMLS:C4023186	hp.json		http://purl.obolibrary.org/obo/HP_0011792		
HP:0011793	biolink:PhenotypicFeature	Neoplasm by anatomical site	Neoplasm categorized according to the anatomical site of origin of the neoplasm.	UMLS:C4023185	hp.json		http://purl.obolibrary.org/obo/HP_0011793		
HP:0008141	biolink:PhenotypicFeature	Dislocation of toes		UMLS:C0434717|SNOMEDCT_US:263030002	hp.json	Dislocation of toes	http://purl.obolibrary.org/obo/HP_0008141		
HP:0011794	biolink:PhenotypicFeature	Embryonal renal neoplasm	The presence of an embryonal neoplasm of the kidney that primarily affects children.	UMLS:C4023184	hp.json		http://purl.obolibrary.org/obo/HP_0011794		
HP:0011795	biolink:PhenotypicFeature	Intralobar nephroblastomatosis	Presence of persistent islands of renal blastema in the postnatal kidney, anywhere within a renal lobe (a portion of a kidney consisting of a renal pyramid and the renal cortex above it).	UMLS:C1319016|SNOMEDCT_US:405934001	hp.json		http://purl.obolibrary.org/obo/HP_0011795		
HP:0011796	biolink:PhenotypicFeature	Perilobar nephroblastomatosis	Abnormally persistent foci of embryonal immature blastema located in the superficial cortical region (perilobar).	UMLS:C1319017|SNOMEDCT_US:405935000	hp.json		http://purl.obolibrary.org/obo/HP_0011796		
HP:0011797	biolink:PhenotypicFeature	Papillary renal cell carcinoma type 1	A type of papillary renal cell carcinoma that is characterized by small cuboidal cells covering thin papillae with a single line of uniform nuclei and small nucleoli.	UMLS:C1336839	hp.json		http://purl.obolibrary.org/obo/HP_0011797		
HP:0011798	biolink:PhenotypicFeature	Renal oncocytoma	A renal tumor originating from an oncocyte, which is an epithelial cell characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm.	UMLS:C0346255|MSH:C537750|SNOMEDCT_US:254922006	hp.json		http://purl.obolibrary.org/obo/HP_0011798		
UBERON:0035546	biolink:AnatomicalEntity	uveal vein		SCTID:149683007|FMA:51797	hp.json	ciliary vein	http://purl.obolibrary.org/obo/UBERON_0035546		
HP:0011790	biolink:PhenotypicFeature	Activating thyroid-stimulating hormone receptor defect	Gain-of-function thyroid-stimulating hormone receptor (TSHR) defect.	UMLS:C4023188	hp.json	Activating TSHR defect	http://purl.obolibrary.org/obo/HP_0011790		
UBERON:0035545	biolink:AnatomicalEntity	deep lymphatic vessel	The tubules that carry lymph throughout the body that are in the interior of the body or limbs.	FMA:52012|NCIT:C32439	hp.json	deep lymph vessel	http://purl.obolibrary.org/obo/UBERON_0035545		
CHEBI:63551	biolink:ChemicalSubstance	carbohydrate acid derivative anion	A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative.		hp.json	carbohydrate acid anion derivatives|carbohydrate acid anion derivative|carbohydrate acid derivative anions	http://purl.obolibrary.org/obo/CHEBI_63551		3_STAR
UBERON:0035539	biolink:AnatomicalEntity	esophageal artery	Any of several arteries that arise from the aorta and supply blood to the esophagus.	FMA:4149|UMLS:C0226294|NCIT:C32535|SCTID:56548006	hp.json	aortic esophageal artery|oesophageal artery	http://purl.obolibrary.org/obo/UBERON_0035539		human_reference_atlas
HP:0011799	biolink:PhenotypicFeature	Abnormality of facial soft tissue		UMLS:C4023183	hp.json	Malformation of facial soft tissue|Deformity of facial soft tissue|Abnormality of facial soft tissue|Anomaly of facial soft tissue	http://purl.obolibrary.org/obo/HP_0011799		
HP:0008138	biolink:PhenotypicFeature	Equinus calcaneus	Abnormal plantar flexion of the calcaneus relative to the longitudinal axis of the tibia. This results in the angle between the long axis of the tibia and the long axis of the heel bone (calcaneus) being greater than 90 degrees.	UMLS:C1860449	hp.json	Equinus deformity of the calcaneus|Hindfoot equinus	http://purl.obolibrary.org/obo/HP_0008138		
HP:0008132	biolink:PhenotypicFeature	Medial rotation of the medial malleolus		UMLS:C3805726	hp.json		http://purl.obolibrary.org/obo/HP_0008132		
HP:0008131	biolink:PhenotypicFeature	Tarsal stippling	The presence of abnormal punctate (speckled, dot-like) calcifications in one or more tarsal bones.	UMLS:C1844848	hp.json	Punctate tarsal calcification|Punctate calcifications of tarsals	http://purl.obolibrary.org/obo/HP_0008131		
HP:0008134	biolink:PhenotypicFeature	Irregular tarsal ossification	Defective ossification in an irregular pattern of the seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.	UMLS:C4280415|UMLS:C4021554	hp.json	Irregular tarsal centers|Irregular ankle bone maturation|Irregular tarsal centres	http://purl.obolibrary.org/obo/HP_0008134		
HP:0008133	biolink:PhenotypicFeature	Distal tapering of metatarsals		UMLS:C4024729	hp.json		http://purl.obolibrary.org/obo/HP_0008133		
HP:0011780	biolink:PhenotypicFeature	Thyroid hemiagenesis	Absence of a lobe of the thyroid gland related to a failure of its embryologic development.	UMLS:C4023190|SNOMEDCT_US:715734006	hp.json		http://purl.obolibrary.org/obo/HP_0011780		
HP:0008150	biolink:PhenotypicFeature	Elevated serum transaminases during infections	Elevations of the levels of SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) that occur during infections.	UMLS:C1864179	hp.json		http://purl.obolibrary.org/obo/HP_0008150		
HP:0011781	biolink:PhenotypicFeature	Thyroid C cell hyperplasia	An abnormal growth of parafollicular (C-cells) cells.	UMLS:C0342190|SNOMEDCT_US:237552009	hp.json		http://purl.obolibrary.org/obo/HP_0011781		
PR:000003918	biolink:Protein	albumin	A protein that is a translation product of the human ALB gene or a 1:1 ortholog thereof.		hp.json	GIG42|GIG20|ALB|PRO2675|PRO1708|PRO2044|Alb-1|Alb1|PRO2619|PRO0903|UNQ696/PRO1341|serum albumin	http://purl.obolibrary.org/obo/PR_000003918		
HP:0011782	biolink:PhenotypicFeature	Thyroid crisis		UMLS:C0040127|SNOMEDCT_US:29028009|MSH:D013958	hp.json		http://purl.obolibrary.org/obo/HP_0011782		
HP:0008151	biolink:PhenotypicFeature	Prolonged prothrombin time	Increased time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT.	SNOMEDCT_US:409674002|UMLS:C0151872	hp.json	Prolonged PT|Increased international normalized ratio|Reduced factor II activity|increased international normalised ratio|Increased international normalised ratio|Low factor II activity|Reduced prothrombin activity|Increased INR	http://purl.obolibrary.org/obo/HP_0008151		
HP:0011783	biolink:PhenotypicFeature	Thyrotoxicosis from ectopic thyroid tissue		UMLS:C0154148|SNOMEDCT_US:87232008	hp.json		http://purl.obolibrary.org/obo/HP_0011783		
HP:0011784	biolink:PhenotypicFeature	Thyrotoxicosis with diffuse goiter		SNOMEDCT_US:267374005|UMLS:C0342122	hp.json	Thyrotoxicosis with diffuse goitre	http://purl.obolibrary.org/obo/HP_0011784		
HP:0011785	biolink:PhenotypicFeature	Thyrotoxicosis with toxic multinodular goiter		SNOMEDCT_US:26389007|UMLS:C0154143	hp.json	Thyrotoxicosis with toxic multinodular goitre	http://purl.obolibrary.org/obo/HP_0011785		
HP:0011786	biolink:PhenotypicFeature	Thyrotoxicosis with toxic single thyroid nodule		UMLS:C0154141|SNOMEDCT_US:69329005|SNOMEDCT_US:73869005	hp.json		http://purl.obolibrary.org/obo/HP_0011786		
HP:0011787	biolink:PhenotypicFeature	Central hypothyroidism	A type of hypothyroidism due to an insufficient stimulation of an otherwise normal thyroid gland. Central hypothyroidism is caused by either pituitary (secondary hypothyroidism) or hypothalamic (tertiary hypothyroidism) defects.	UMLS:C0271801|SNOMEDCT_US:26692000	hp.json		http://purl.obolibrary.org/obo/HP_0011787		
UBERON:0035551	biolink:AnatomicalEntity	deep vasculature	The part of the circulatory system that lies deep beneath the subcutaneous tissue layers away from the surface of the skin.		hp.json	deep part of circulatory system	http://purl.obolibrary.org/obo/UBERON_0035551		
CHEBI:63561	biolink:ChemicalSubstance	ketoaldonate derivative	A carbohydrate acid derivative anion that is formally obtained from a ketoaldonate.		hp.json	ketoaldonate derivatives	http://purl.obolibrary.org/obo/CHEBI_63561		3_STAR
UBERON:0035550	biolink:AnatomicalEntity	superficial vein	Any of the veins carrying deoxygenated blood from the subcutaneous tissue layers.	UMLS:C0226513|Wikipedia:Superficial_vein|FMA:76719|SCTID:341382008|NCIT:C33666	hp.json	superficial veins|superficial vessels|superfical vein|superficial veins|superfical vein|superficial vessels	http://purl.obolibrary.org/obo/UBERON_0035550		
UBERON:0035553	biolink:AnatomicalEntity	left cardiac chamber	Any chamber of the left side of the heart.	FMA:7166|SCTID:362008007	hp.json		http://purl.obolibrary.org/obo/UBERON_0035553		
UBERON:0035552	biolink:AnatomicalEntity	deep vein	A blood vessel carrying deoxygenated blood far beneath the skin usually accompanying an artery.	SCTID:341484008|NCIT:C32444|UMLS:C0226514|Wikipedia:Deep_vein|FMA:76718	hp.json	deep veins|deep veins|deep vessels|deep vessels	http://purl.obolibrary.org/obo/UBERON_0035552		
UBERON:0035554	biolink:AnatomicalEntity	right cardiac chamber	Any chamber of the right side of the heart.	FMA:7165|SCTID:362007002	hp.json		http://purl.obolibrary.org/obo/UBERON_0035554		
CHEBI:63563	biolink:ChemicalSubstance	oligosaccharide derivative	A carbohydrate derivative that is formally obtained from an oligosaccharide.		hp.json	O-glycosylglycoside derivative|O-glycosylglycoside derivatives|oligosaccharide derivatives	http://purl.obolibrary.org/obo/CHEBI_63563		3_STAR
UBERON:0035548	biolink:AnatomicalEntity	colic artery		SCTID:77852007	hp.json		http://purl.obolibrary.org/obo/UBERON_0035548		
UBERON:0035549	biolink:AnatomicalEntity	vasculature of integument	The part of the circulatory system that lies within the subcutaneous tissue layers close to the surface of the skin.	FMA:225275	hp.json	superficial vasculature|dermis vasculature|hypodermis vasculature|skin vasculature|vasculature of skin|superficial part of circulatory system|subcutaneous vasculature	http://purl.obolibrary.org/obo/UBERON_0035549		human_reference_atlas
HP:0011788	biolink:PhenotypicFeature	Increased circulating free T3	An elevated concentration of free 3,3',5-triiodo-L-thyronine in the blood circulation.	UMLS:C4021843	hp.json	Increased serum free triiodothyronine|Increased circulating free triiodothyronine|Increased serum free T3|Increased serum fT3	http://purl.obolibrary.org/obo/HP_0011788		
HP:0011789	biolink:PhenotypicFeature	Impaired sensitivity to thyroid stimulating hormone	Reduced sensitivity of thyroid follicle cells to stimulation by biologically active thyroid-stimulating hormone (TSH).	UMLS:C4023189	hp.json	TSHR defect|Thyroid-stimulating hormone receptor defect	http://purl.obolibrary.org/obo/HP_0011789		
HP:0008148	biolink:PhenotypicFeature	Impaired epinephrine-induced platelet aggregation	Abnormal response to epinephrine as manifested by reduced or lacking aggregation of platelets upon addition of epinephrine.	UMLS:C4024727	hp.json		http://purl.obolibrary.org/obo/HP_0008148		
HP:0008142	biolink:PhenotypicFeature	Delayed calcaneal ossification	Delayed maturation and calcification of the calcaneus.	UMLS:C4280414|UMLS:C4024728	hp.json	Delayed heel bone maturation	http://purl.obolibrary.org/obo/HP_0008142		
HP:0008144	biolink:PhenotypicFeature	Flattening of the talar dome		UMLS:C1843986	hp.json		http://purl.obolibrary.org/obo/HP_0008144		
GO:0099531	biolink:BiologicalProcess	presynaptic process involved in chemical synaptic transmission	The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission.		hp.json		http://purl.obolibrary.org/obo/GO_0099531		gocheck_do_not_annotate|goslim_synapse
NCBITaxon:4896	biolink:OrganismalEntity	Schizosaccharomyces pombe		GC_ID:1	hp.json	fission yeast|Schizosaccharomyces malidevorans	http://purl.obolibrary.org/obo/NCBITaxon_4896		
NCBITaxon:4894	biolink:OrganismalEntity	Schizosaccharomycetaceae		GC_ID:1	hp.json	fission yeasts|Schizosaccharomycetoideae	http://purl.obolibrary.org/obo/NCBITaxon_4894		
NCBITaxon:4895	biolink:OrganismalEntity	Schizosaccharomyces		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_4895		
GO:1903353	biolink:BiologicalProcess	regulation of nucleus organization	Any process that modulates the frequency, rate or extent of nucleus organization.		hp.json	regulation of nuclear organisation|regulation of nuclear morphology|regulation of nuclear organization and biogenesis|regulation of nucleus organization and biogenesis|regulation of nuclear organization	http://purl.obolibrary.org/obo/GO_1903353		
GO:1903351	biolink:BiologicalProcess	cellular response to dopamine	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_1903351		
GO:1903350	biolink:BiologicalProcess	response to dopamine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_1903350		
CHEBI:133610	biolink:ChemicalSubstance	N-isobutyrylglycinate	A monocarboxylic acid anion that is the conjugate base of N-isobutyrylglycine, obtained by deprotonation of the carboxy group; major species at pH 7.3.	HMDB:HMDB0000730	hp.json	isobutyrylglycinate|isobutanoylglycinate|N-isobutanoylglycinate|N-(2-methylpropanoyl)glycinate|(2-methylpropanamido)acetate	http://purl.obolibrary.org/obo/CHEBI_133610		3_STAR
GO:0002625	biolink:BiologicalProcess	regulation of T cell antigen processing and presentation	Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.		hp.json	regulation of T-cell antigen processing and presentation|regulation of T lymphocyte antigen processing and presentation|regulation of T-lymphocyte antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002625		
GO:0099537	biolink:BiologicalProcess	trans-synaptic signaling	Cell-cell signaling in either direction across the synaptic cleft.		hp.json		http://purl.obolibrary.org/obo/GO_0099537		goslim_synapse
GO:0051596	biolink:BiologicalProcess	methylglyoxal catabolic process	The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.	MetaCyc:METHGLYUT-PWY|MetaCyc:Methylglyoxal-Detoxification	hp.json	methylglyoxal breakdown|methylglyoxal catabolism|methylglyoxal degradation	http://purl.obolibrary.org/obo/GO_0051596		
GO:0099538	biolink:BiologicalProcess	synaptic signaling via neuropeptide	Cell-cell signaling to or from a synapse, mediated by a peptide.		hp.json		http://purl.obolibrary.org/obo/GO_0099538		goslim_synapse
GO:0002626	biolink:BiologicalProcess	negative regulation of T cell antigen processing and presentation	Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.		hp.json	down regulation of T cell antigen processing and presentation|inhibition of T cell antigen processing and presentation|down-regulation of T cell antigen processing and presentation|negative regulation of T-cell antigen processing and presentation|negative regulation of T lymphocyte antigen processing and presentation|negative regulation of T-lymphocyte antigen processing and presentation|downregulation of T cell antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002626		
GO:0002627	biolink:BiologicalProcess	positive regulation of T cell antigen processing and presentation	Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.		hp.json	positive regulation of T-lymphocyte antigen processing and presentation|upregulation of T cell antigen processing and presentation|up regulation of T cell antigen processing and presentation|stimulation of T cell antigen processing and presentation|positive regulation of T-cell antigen processing and presentation|positive regulation of T lymphocyte antigen processing and presentation|activation of T cell antigen processing and presentation|up-regulation of T cell antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002627		
GO:0099536	biolink:BiologicalProcess	synaptic signaling	Cell-cell signaling to, from or within a synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099536		goslim_synapse|goslim_drosophila
HP:0550003	biolink:PhenotypicFeature	Proximal scleroderma	Symmetrical thickening, tightening and induration of the skin of the fingers and the skin proximal to the metacarpophalangeal or metatarsophalangeal joints. These changes can involve the entire limb, face, neck and trunk.		hp.json		http://purl.obolibrary.org/obo/HP_0550003		
GO:0099540	biolink:BiologicalProcess	trans-synaptic signaling by neuropeptide	Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft.		hp.json		http://purl.obolibrary.org/obo/GO_0099540		goslim_synapse
HP:0550004	biolink:PhenotypicFeature	Verruca plana	Slightly raised wart 2-5 mm in diameter often associated with viral infections, commonly persistent in immunodeficient individuals.		hp.json	Flat wart	http://purl.obolibrary.org/obo/HP_0550004		
GO:0099541	biolink:BiologicalProcess	trans-synaptic signaling by lipid	Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid.		hp.json		http://purl.obolibrary.org/obo/GO_0099541		goslim_synapse
HP:0550005	biolink:PhenotypicFeature	Bilateral basilar pulmonary fibrosis	It is a bilateral reticular pattern of linear or lineonodular densities that are most pronounced in basilar portions of the lungs on standard chest x-ray. It is the third minor criterion for scleroderma diagnosis.		hp.json	Lung disease with systemic sclerosis|Scleroderma lung disease|Scleroderma of lung	http://purl.obolibrary.org/obo/HP_0550005		
GO:1903358	biolink:BiologicalProcess	regulation of Golgi organization	Any process that modulates the frequency, rate or extent of Golgi organization.		hp.json	regulation of Golgi organisation|regulation of Golgi organization and biogenesis	http://purl.obolibrary.org/obo/GO_1903358		
GO:0099547	biolink:BiologicalProcess	regulation of translation at synapse, modulating synaptic transmission	Any process that modulates synaptic transmission by regulating translation occurring at the synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099547		goslim_synapse
CHEBI:51569	biolink:ChemicalSubstance	N-acyl-amino acid	A carboxamide resulting from the formal condensation of a carboxylic acid with the amino group of an amino acid.		hp.json	acylamino acids|acyl-amino-acids|N-acyl-amino-acids|N-acyl amino acid|N-acyl amino acids|N-acyl-amino-acid|acyl-amino-acid|N-acylamino acid|N-acylamino acids	http://purl.obolibrary.org/obo/CHEBI_51569		3_STAR
GO:0099512	biolink:CellularComponent	supramolecular fiber	A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.		hp.json	fibril	http://purl.obolibrary.org/obo/GO_0099512		
GO:0002607	biolink:BiologicalProcess	regulation of myeloid dendritic cell antigen processing and presentation	Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.		hp.json		http://purl.obolibrary.org/obo/GO_0002607		
GO:0002608	biolink:BiologicalProcess	negative regulation of myeloid dendritic cell antigen processing and presentation	Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.		hp.json	downregulation of myeloid dendritic cell antigen processing and presentation|down regulation of myeloid dendritic cell antigen processing and presentation|inhibition of myeloid dendritic cell antigen processing and presentation|down-regulation of myeloid dendritic cell antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002608		
GO:0002609	biolink:BiologicalProcess	positive regulation of myeloid dendritic cell antigen processing and presentation	Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.		hp.json	up regulation of myeloid dendritic cell antigen processing and presentation|stimulation of myeloid dendritic cell antigen processing and presentation|up-regulation of myeloid dendritic cell antigen processing and presentation|activation of myeloid dendritic cell antigen processing and presentation|upregulation of myeloid dendritic cell antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002609		
GO:0099518	biolink:BiologicalProcess	vesicle cytoskeletal trafficking	The directed movement of a vesicle along a cytoskeletal fiber such as a microtubule or and actin filament, mediated by motor proteins.		hp.json	cytoskeletal fiber-based vesicle localization|vesicle cytoskeletal transport	http://purl.obolibrary.org/obo/GO_0099518		
GO:0002604	biolink:BiologicalProcess	regulation of dendritic cell antigen processing and presentation	Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation.		hp.json		http://purl.obolibrary.org/obo/GO_0002604		
GO:0002605	biolink:BiologicalProcess	negative regulation of dendritic cell antigen processing and presentation	Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.		hp.json	down regulation of dendritic cell antigen processing and presentation|inhibition of dendritic cell antigen processing and presentation|down-regulation of dendritic cell antigen processing and presentation|downregulation of dendritic cell antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002605		
GO:0099513	biolink:CellularComponent	polymeric cytoskeletal fiber	A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits.		hp.json		http://purl.obolibrary.org/obo/GO_0099513		
GO:0002606	biolink:BiologicalProcess	positive regulation of dendritic cell antigen processing and presentation	Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.		hp.json	upregulation of dendritic cell antigen processing and presentation|up regulation of dendritic cell antigen processing and presentation|stimulation of dendritic cell antigen processing and presentation|up-regulation of dendritic cell antigen processing and presentation|activation of dendritic cell antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002606		
GO:0002613	biolink:BiologicalProcess	regulation of monocyte antigen processing and presentation	Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation.		hp.json		http://purl.obolibrary.org/obo/GO_0002613		
CHEBI:133608	biolink:ChemicalSubstance	1-methylhistidine zwitterion	An alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of 1-methylhistidine; major species at pH 7.3.		hp.json	2-azaniumyl-3-(1-methyl-1H-imidazol-4-yl)propanoate	http://purl.obolibrary.org/obo/CHEBI_133608		3_STAR
GO:1903379	biolink:BiologicalProcess	regulation of mitotic chromosome condensation	Any process that modulates the frequency, rate or extent of mitotic chromosome condensation.		hp.json		http://purl.obolibrary.org/obo/GO_1903379		
CHEBI:133609	biolink:ChemicalSubstance	3-methylhistidine zwitterion	An alpha-amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of 3-methylhistidine; major species at pH 7.3.		hp.json	2-azaniumyl-3-(1-methyl-1H-imidazol-5-yl)propanoate	http://purl.obolibrary.org/obo/CHEBI_133609		3_STAR
GO:1903380	biolink:BiologicalProcess	positive regulation of mitotic chromosome condensation	Any process that activates or increases the frequency, rate or extent of mitotic chromosome condensation.		hp.json	up-regulation of mitotic chromosome condensation|up regulation of mitotic chromosome condensation|activation of mitotic chromosome condensation|upregulation of mitotic chromosome condensation	http://purl.obolibrary.org/obo/GO_1903380		
GO:0002618	biolink:BiologicalProcess	positive regulation of macrophage antigen processing and presentation	Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation.		hp.json	up regulation of macrophage antigen processing and presentation|stimulation of macrophage antigen processing and presentation|up-regulation of macrophage antigen processing and presentation|activation of macrophage antigen processing and presentation|upregulation of macrophage antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002618		
NCBITaxon:4892	biolink:OrganismalEntity	Saccharomycetales		GC_ID:1	hp.json	budding yeasts|Endomycetales	http://purl.obolibrary.org/obo/NCBITaxon_4892		
NCBITaxon:4893	biolink:OrganismalEntity	Saccharomycetaceae		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_4893		
NCBITaxon:4890	biolink:OrganismalEntity	Ascomycota		GC_ID:1|PMID:17572334	hp.json	ascomycetes|sac fungi|ascomycetes	http://purl.obolibrary.org/obo/NCBITaxon_4890		
NCBITaxon:4891	biolink:OrganismalEntity	Saccharomycetes		GC_ID:1	hp.json	Hemiascomycetes	http://purl.obolibrary.org/obo/NCBITaxon_4891		
GO:0002614	biolink:BiologicalProcess	negative regulation of monocyte antigen processing and presentation	Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation.		hp.json	downregulation of monocyte antigen processing and presentation|down regulation of monocyte antigen processing and presentation|inhibition of monocyte antigen processing and presentation|down-regulation of monocyte antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002614		
GO:0002615	biolink:BiologicalProcess	positive regulation of monocyte antigen processing and presentation	Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation.		hp.json	stimulation of monocyte antigen processing and presentation|up regulation of monocyte antigen processing and presentation|up-regulation of monocyte antigen processing and presentation|activation of monocyte antigen processing and presentation|upregulation of monocyte antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002615		
GO:0002616	biolink:BiologicalProcess	regulation of macrophage antigen processing and presentation	Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation.		hp.json		http://purl.obolibrary.org/obo/GO_0002616		
GO:0002617	biolink:BiologicalProcess	negative regulation of macrophage antigen processing and presentation	Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.		hp.json	downregulation of macrophage antigen processing and presentation|down regulation of macrophage antigen processing and presentation|inhibition of macrophage antigen processing and presentation|down-regulation of macrophage antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002617		
GO:0099577	biolink:BiologicalProcess	regulation of translation at presynapse, modulating synaptic transmission	Any process that modulates synaptic transmission by regulating translation occurring at the presynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099577		goslim_synapse
GO:0099578	biolink:BiologicalProcess	regulation of translation at postsynapse, modulating synaptic transmission	Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099578		goslim_synapse
HP:0011730	biolink:PhenotypicFeature	Abnormal central sensory function	An abnormality of sensation related to CNS function. Assuming the primary sensory modalities are intact and the patient is alert and cooperative, the presence of an abnormality of sensory function may indicate a lesion of a parietal cortex, the thalamocortical projections to the parietal cortex, or the spinal cord.	UMLS:C4023215	hp.json	Abnormality of central sensory function	http://purl.obolibrary.org/obo/HP_0011730		
HP:0011731	biolink:PhenotypicFeature	Abnormality of circulating cortisol level	An abnormality of the concentration of cortisol in the blood.	UMLS:C4023214	hp.json		http://purl.obolibrary.org/obo/HP_0011731		
GO:0099571	biolink:CellularComponent	postsynaptic cytoskeleton	The portion of the cytoskeleton contained within the postsynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099571		goslim_synapse
HP:0011732	biolink:PhenotypicFeature	Abnormality of adrenal morphology	Any structural anomaly of the adrenal glands.	UMLS:C4023213	hp.json		http://purl.obolibrary.org/obo/HP_0011732		
HP:0011733	biolink:PhenotypicFeature	Abnormality of adrenal physiology	A functional abnormality of the adrenal glands.	UMLS:C4023212	hp.json		http://purl.obolibrary.org/obo/HP_0011733		
HP:0011734	biolink:PhenotypicFeature	Central adrenal insufficiency	A form of adrenal insufficiency related to a lack of ACTH, which leads to a decrease in the production of cortisol by the adrenal glands. Aldosterone production is not usually affected.	UMLS:C0948387	hp.json	Secondary adrenal insufficiency	http://purl.obolibrary.org/obo/HP_0011734		
CHEBI:38560	biolink:ChemicalSubstance	simple protein			hp.json	simple proteins	http://purl.obolibrary.org/obo/CHEBI_38560		3_STAR
HP:0011735	biolink:PhenotypicFeature	Adrenocorticotropin deficient adrenal insufficiency	Adrenal insufficiency secondary to a defect in ACTH production.	UMLS:C4023211	hp.json	ACTH deficient adrenal insufficiency	http://purl.obolibrary.org/obo/HP_0011735		
HP:0011736	biolink:PhenotypicFeature	Primary hyperaldosteronism	A form of hyperaldosteronism caused by a defect within the adrenal gland.	SNOMEDCT_US:190507007|SNOMEDCT_US:258117004|MSH:D006929|UMLS:C1384514	hp.json		http://purl.obolibrary.org/obo/HP_0011736		
HP:0011737	biolink:PhenotypicFeature	Corticotropin-releasing hormone deficient adrenal insufficiency	Adrenal insufficiency secondary to a defect in corticotropin-releasing hormone production.	UMLS:C4021127	hp.json	Tertiary adrenal insufficiency|CRH deficient adrenal insufficiency	http://purl.obolibrary.org/obo/HP_0011737		
HP:0011738	biolink:PhenotypicFeature	Corticotropin-releasing hormone receptor defect	Adrenal insufficiency secondary to a defect in the corticotropin-releasing hormone receptor.	UMLS:C4023210|UMLS:C4020745	hp.json	CRHR defect|Corticotropin-releasing hormone receptor (CRHR) resistance	http://purl.obolibrary.org/obo/HP_0011738		
HP:0011739	biolink:PhenotypicFeature	Dexamethasone-suppressible primary hyperaldosteronism	A form of primary hyperaldosteronism in which the overproduction of aldosterone can be suppressed by the administration of dexamethasone.	UMLS:C4023209|UMLS:C4020744|UMLS:C4020743	hp.json	Glucocorticoid-remediable familial primary aldosteronism|Familial primary hyperaldosteronism type 1	http://purl.obolibrary.org/obo/HP_0011739		
GO:0099589	biolink:MolecularActivity	serotonin receptor activity	Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.		hp.json		http://purl.obolibrary.org/obo/GO_0099589		
HP:0011720	biolink:PhenotypicFeature	Cardiac total anomalous pulmonary venous connection	Type 2 total anomalous pulmonary venous connection.	UMLS:C4021130|Fyler:0920|Fyler:0930|Fyler:920|Fyler:930	hp.json	Cardiac total anomalous pulmonary venous connexion|Total anomalous pulmonary venous connection, intracardiac|Type 2 total anomalous pulmonary venous connection	http://purl.obolibrary.org/obo/HP_0011720		
HP:0011721	biolink:PhenotypicFeature	Infracardiac total anomalous pulmonary venous connection	Type 3 total anomalous pulmonary venous connection.	UMLS:C4021129	hp.json	Infracardiac total anomalous pulmonary venous connexion|Type 3 total anomalous pulmonary venous connection	http://purl.obolibrary.org/obo/HP_0011721		
HP:0011722	biolink:PhenotypicFeature	Mixed total anomalous pulmonary venous connection	Type 4 total anomalous pulmonary venous connection.	Fyler:0950|UMLS:C4021128|Fyler:950	hp.json	Mixed total anomalous pulmonary venous connexion|Total anomalous pulmonary venous connection, mixed|Type 4 total anomalous pulmonary venous connection	http://purl.obolibrary.org/obo/HP_0011722		
HP:0011723	biolink:PhenotypicFeature	Congenital malformation of the right heart	Defect or defects of the morphogenesis of the right heart identifiable at birth.	UMLS:C4023219	hp.json		http://purl.obolibrary.org/obo/HP_0011723		
HP:0011724	biolink:PhenotypicFeature	Uhl's anomaly	Uhl anomaly of the right ventricle refers to the almost complete absence of right ventricular myocardium, normal tricuspid valve, and preserved septal and left ventricular myocardium.	SNOMEDCT_US:2829000|MSH:C536932|UMLS:C0265857	hp.json		http://purl.obolibrary.org/obo/HP_0011724		
HP:0011725	biolink:PhenotypicFeature	Chaotic multifocal atrial tachycardia		UMLS:C4023218	hp.json		http://purl.obolibrary.org/obo/HP_0011725		
HP:0011726	biolink:PhenotypicFeature	Persistent fetal circulation	Systemic desaturation of a liveborn baby resulting from persistent pulmonary hypertension with a patent ductus arteriosus and patent foramen ovale, such that the circulation in postnatal life follows the fetal course.	SNOMEDCT_US:206597007|MSH:D010547|SNOMEDCT_US:35604006|SNOMEDCT_US:233815004|UMLS:C0031190	hp.json	Persistent foetal circulation	http://purl.obolibrary.org/obo/HP_0011726		
HP:0011727	biolink:PhenotypicFeature	Peroneal muscle weakness	Weakness of the peroneal muscles.	UMLS:C0240733	hp.json	Fibularis muscle weakness	http://purl.obolibrary.org/obo/HP_0011727		
HP:0011728	biolink:PhenotypicFeature	Elbow clonus	Clonus at the elbow joint, i.e., an exaggerated phasic stretch reflex characterized by repetitive, rhythmic contractions at the elbow, generated by rapid passive stretch at the elbow joint.	UMLS:C4023217	hp.json		http://purl.obolibrary.org/obo/HP_0011728		
HP:0011729	biolink:PhenotypicFeature	Abnormality of joint mobility	An abnormality in the range and ease of motion of joints across their normal range.	UMLS:C4023216	hp.json		http://purl.obolibrary.org/obo/HP_0011729		
GO:0099551	biolink:BiologicalProcess	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099551		goslim_synapse
GO:0099552	biolink:BiologicalProcess	trans-synaptic signaling by lipid, modulating synaptic transmission	Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099552		goslim_synapse
HP:0011710	biolink:PhenotypicFeature	Bundle branch block	Block of conduction of electrical impulses along the Bundle of His or along one of its bundle branches.	MSH:D002037|SNOMEDCT_US:6374002|UMLS:C0006384	hp.json	Bundle-branch block	http://purl.obolibrary.org/obo/HP_0011710		
GO:0099550	biolink:BiologicalProcess	trans-synaptic signaling, modulating synaptic transmission	Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099550		goslim_synapse
HP:0011719	biolink:PhenotypicFeature	Supracardiac total anomalous pulmonary venous connection	Type 1 total anomalous pulmonary venous connection.	Fyler:910|UMLS:C4021131|Fyler:0910	hp.json	Total anomalous pulmonary venous connection, supracardiac|Supracardiac total anomalous pulmonary venous connexion|Type 1 total anomalous pulmonary venous connection	http://purl.obolibrary.org/obo/HP_0011719		
HP:0011711	biolink:PhenotypicFeature	Left anterior fascicular block	Conduction block in the anterior division of the left bundle branch of the bundle of His.	SNOMEDCT_US:37760005|UMLS:C0264912	hp.json	Left anterior hemiblock	http://purl.obolibrary.org/obo/HP_0011711		
HP:0011712	biolink:PhenotypicFeature	Right bundle branch block	A conduction block of the right branch of the bundle of His. This manifests as a prolongation of the QRS complex (greater than 0.12 s) with delayed activation of the right ventricle and terminal delay on the EKG.	MSH:D002037|UMLS:C0085615|SNOMEDCT_US:59118001	hp.json	Right bundle-branch block	http://purl.obolibrary.org/obo/HP_0011712		
HP:0011713	biolink:PhenotypicFeature	Left bundle branch block	A conduction block of the left branch of the bundle of His. This manifests as a generalized disturbance of QRS morphology on EKG.	SNOMEDCT_US:63467002|MSH:D002037|UMLS:C0023211	hp.json		http://purl.obolibrary.org/obo/HP_0011713		
HP:0011714	biolink:PhenotypicFeature	Libman-Sacks lesions	Libman-Sacks valvular lesions are sterile fibrofibrinous vegetations that favor the left-sided heart valves and usually form on the ventricular surface of the mitral valve.	UMLS:C4023221	hp.json		http://purl.obolibrary.org/obo/HP_0011714		
HP:0011715	biolink:PhenotypicFeature	Trifascicular block	Abnormal conduction in all three divisions of the intraventricular conducting tissue.	SNOMEDCT_US:86014007|UMLS:C0155707	hp.json		http://purl.obolibrary.org/obo/HP_0011715		
HP:0011716	biolink:PhenotypicFeature	Junctional ectopic tachycardia	Junctional ectopic tachycardia (JET) is a unique type of supraventricular arrhythmia defined by narrow QRS complex and atrioventricular (AV) dissociation or retrograde atrial conduction in a 1:1 pattern.	MSH:D013613|SNOMEDCT_US:419166005|UMLS:C0039235|SNOMEDCT_US:233901002	hp.json		http://purl.obolibrary.org/obo/HP_0011716		
HP:0011717	biolink:PhenotypicFeature	Atrioventricular reentrant tachycardia	Accessory pathway-related atrioventricular reentrant tachycardia (AVRT) involves an abnormal electrical conduction of the accessory pathway. The accessory pathway connecting impulses between the atrium and the ventricle can be seen at any site in the AV groove.	UMLS:C4023220	hp.json	AV nodal reentry tachycardia	http://purl.obolibrary.org/obo/HP_0011717		
HP:0011718	biolink:PhenotypicFeature	Abnormality of the pulmonary veins	An abnormality of the pulmonary veins.	UMLS:C0265914|SNOMEDCT_US:199113001|SNOMEDCT_US:111322000|SNOMEDCT_US:128585006	hp.json	Abnormality of lung veins	http://purl.obolibrary.org/obo/HP_0011718		
GO:0099565	biolink:BiologicalProcess	chemical synaptic transmission, postsynaptic	The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol.		hp.json	postsynaptic process involved in chemical synaptic transmission	http://purl.obolibrary.org/obo/GO_0099565		goslim_synapse|gocheck_do_not_annotate
HP:0011708	biolink:PhenotypicFeature	Mobitz II atrioventricular block	A type of second degree atrioventricular (AV) block characterized by sudden failure to conduct an impulse through the AV node without a preceding change in the PR interval.	SNOMEDCT_US:28189009|UMLS:C0155700	hp.json	Mobitz type 2 atrioventricular block	http://purl.obolibrary.org/obo/HP_0011708		
HP:0011709	biolink:PhenotypicFeature	Atrioventricular dissociation	Atrioventricular (AV) dissociation is present if the atria and the ventricles are under the control of two separate pacemakers. AV dissociation can occur in the absence of a primary AV conduction disturbance.	UMLS:C0004331|SNOMEDCT_US:50799005|MSH:D006327	hp.json		http://purl.obolibrary.org/obo/HP_0011709		
HP:0011700	biolink:PhenotypicFeature	Automatic atrial tachycardia	Chronic supraventricular tachycardia predominantly seen in childhood.	MSH:D013612|SNOMEDCT_US:233892002|UMLS:C0039234	hp.json		http://purl.obolibrary.org/obo/HP_0011700		
HP:0011701	biolink:PhenotypicFeature	Multifocal atrial tachycardia	Multifocal atrial tachycardia is a rare supraventricular arrhythmia in neonates and young infants that is characterized by multiple P waves with varying P wave morphology and is usually asymptomatic.	UMLS:C0221158|SNOMEDCT_US:49982000	hp.json	Ectopic atrial tachycardia|Chaotic atrial tachycardia	http://purl.obolibrary.org/obo/HP_0011701		
HP:0011702	biolink:PhenotypicFeature	Abnormal electrophysiology of sinoatrial node origin	An abnormality of the sinoatrial (SA) node in the right atrium. THe SA node acts as the pacemaker of the heart.	UMLS:C4023222|Fyler:7010	hp.json		http://purl.obolibrary.org/obo/HP_0011702		
HP:0011703	biolink:PhenotypicFeature	Sinus tachycardia	Heart rate of greater than 100 beats per minute.	SNOMEDCT_US:11092001|UMLS:C0039239|MSH:D013616	hp.json	Sinus tachy|Sinus tach	http://purl.obolibrary.org/obo/HP_0011703		
HP:0011704	biolink:PhenotypicFeature	Sick sinus syndrome	An abnormality involving the generation of the action potential by the sinus node and is characterized by an atrial rate inappropriate for physiological requirements. Manifestations include severe sinus bradycardia, sinus pauses or arrest, sinus node exit block, chronic atrial tachyarrhythmias, alternating periods of atrial bradyarrhythmias and tachyarrhythmias, and inappropriate responses of heart rate during exercise or stress.	UMLS:C0037052|MSH:D012804|SNOMEDCT_US:36083008	hp.json	Sinoatrial node disease	http://purl.obolibrary.org/obo/HP_0011704		
HP:0011705	biolink:PhenotypicFeature	First degree atrioventricular block	Delay of conduction through the atrioventricular node, which is manifested as prolongation of the PR interval in the electrocardiogram (EKG). All atrial impulses reach the ventricles.	UMLS:C0085614|SNOMEDCT_US:270492004	hp.json		http://purl.obolibrary.org/obo/HP_0011705		
GO:0099568	biolink:CellularComponent	cytoplasmic region	Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm.		hp.json		http://purl.obolibrary.org/obo/GO_0099568		gocheck_do_not_annotate
HP:0011706	biolink:PhenotypicFeature	Second degree atrioventricular block	An intermittent atrioventricular block with failure of some atrial impulses to conduct to the ventricles, i.e., some but not all atrial impulses are conducted through the atrioventricular node and trigger ventricular contraction.	SNOMEDCT_US:195042002|UMLS:C0264906	hp.json		http://purl.obolibrary.org/obo/HP_0011706		
HP:0011707	biolink:PhenotypicFeature	Mobitz I atrioventricular block	Progressive PR interval prolongation with the subsequent occurrence of a single nonconducted P wave that results in a pause. The pause that follows the nonconducted impulse is less than fully compensatory (less than the sum of two normal sinus intervals).	SNOMEDCT_US:54016002|UMLS:C0264907	hp.json	Wenckebach block|Mobitz type 1 atrioventricular block	http://purl.obolibrary.org/obo/HP_0011707		
GO:0099569	biolink:CellularComponent	presynaptic cytoskeleton	The portion of the cytoskeleton contained within the presynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099569		goslim_synapse
GO:0002580	biolink:BiologicalProcess	regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.		hp.json	regulation of peptide or polysaccharide antigen processing and presentation via MHC class II	http://purl.obolibrary.org/obo/GO_0002580		
GO:0002581	biolink:BiologicalProcess	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.		hp.json	negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II|down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	http://purl.obolibrary.org/obo/GO_0002581		
GO:0002582	biolink:BiologicalProcess	positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.		hp.json	up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II|upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	http://purl.obolibrary.org/obo/GO_0002582		
CHEBI:157668	biolink:ChemicalSubstance	carbocyclic fatty acid anion	Any fatty acid anion containing a ring composed of carbon atoms. Major microspecies at pH 7.3		hp.json	carbocyclic fatty acid	http://purl.obolibrary.org/obo/CHEBI_157668		2_STAR
OBO:MAXO_0000691	biolink:NamedThing	medical oncologist evaluation	An assessment by an internist who specializes in the diagnosis and treatment of all types of cancer and other benign and malignant tumors. This specialist decides on and administers therapy for these malignancies, as well as consults with surgeons and radiotherapists on other treatments for cancer.		hp.json	medical oncology internist evaluation|referral to oncologist|consultation with medical oncologist|medical oncology internist consultation|consultation with medical oncology internist|medical oncologist consultation	http://purl.obolibrary.org/obo/MAXO_0000691		
OBO:MAXO_0000692	biolink:NamedThing	nephrologist evaluation	An assessment by an internist who treats disorders of the kidney, high blood pressure, fluid and mineral balance, and dialysis of body wastes when the kidneys do not function. This specialist consults with surgeons about kidney transplantation.		hp.json	consultation with nephrologist|referral to nephrologist|nephrology internist evaluation|nephrology internist consultation|consultation with nephrology internist|nephrologist consultation	http://purl.obolibrary.org/obo/MAXO_0000692		
OBO:MAXO_0000690	biolink:NamedThing	infectious disease internist evaluation	An assessment by an internist who deals with infectious diseases of all types and in all organ systems. Infectious disease specialists may also have expertise in preventive medicine and travel medicine.		hp.json	infectious disease specialist evaluation|referral to infectious disease internist|infectious disease specialist consultation|consultation with infectious disease specialist	http://purl.obolibrary.org/obo/MAXO_0000690		
PR:000013246	biolink:Protein	prolactin	A somatotropin hormone family member that is a translation product of the human PRL gene or a 1:1 ortholog thereof.		hp.json	PRL	http://purl.obolibrary.org/obo/PR_000013246		
OBO:MAXO_0000693	biolink:NamedThing	pulmonologist evaluation	An assessment by an internist who treats diseases of the lungs and airways. The specialist diagnoses and treats cancer, pneumonia, pleurisy, asthma, occupational and environmental diseases, bronchitis, sleep disorders, emphysema and other complex disorders of the lungs.		hp.json	pulmonary disease internist evaluation|consultation with pulmonary disease specialist|consultation with pulmonary disease internist|pulmonary disease internist consultation|referral to pulmonologist|consultation with pulmonologist|pulmonologist consultation	http://purl.obolibrary.org/obo/MAXO_0000693		
OBO:MAXO_0000694	biolink:NamedThing	rheumatologist evaluation	An assessment by an internist who treats diseases of joints, muscle, bones and tendons. This specialist diagnoses and treats arthritis, back pain, muscle strains, common athletic injuries and collagen diseases.		hp.json	rheumatology specialist evaluation|consultation with rheumatology internist|referral to rhematologist|rheumatology specialist consultation|rheumatologist consultation|consultation with rheumatologist|rheumatology internist evaluation|rheumatology internist consultation	http://purl.obolibrary.org/obo/MAXO_0000694		
OBO:MAXO_0009023	biolink:NamedThing	attention and concentration assessment	Evaluation of a patient's concentration or attention to a prompt or test.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009023		
OBO:MAXO_0009024	biolink:NamedThing	visuospatial skill assessment	Evaluation of a person’s ability to conceptualize and manipulate two- and three-dimensional objects.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009024		
OBO:MAXO_0009021	biolink:NamedThing	abstract reasoning assessment	Evaluation of a patient's ability to analyze information, detect patterns, detect relationships, or problem solveing abilities on an intangible  level.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009021		
PR:000001281	biolink:Protein	ADP-ribosyl cyclase	A protein that contains the ADP-ribosyl cyclase domain (Pfam:PF02267).	PIRSF:PIRSF005736	hp.json		http://purl.obolibrary.org/obo/PR_000001281		
OBO:MAXO_0009022	biolink:NamedThing	memory assessement	Evaluation of short-term and long-term emory in a patient.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009022		
OBO:MAXO_0009020	biolink:NamedThing	executive function assessment	Evaluation of organizing and planning ability, as well as working memory, mental flexibility, list-making, and execution of tasks.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009020		
GO:1905936	biolink:BiologicalProcess	regulation of germ cell proliferation	Any process that modulates the frequency, rate or extent of germ cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_1905936		
OBO:MAXO_0000699	biolink:NamedThing	clinical laboratory geneticist evaluation	An assessment or consultation by a diplomate certified in Laboratory Genetics and Genomics who directs and interprets both clinical cytogenetic and molecular genetic analyses relevant to the diagnosis and management of human genetic disease. This specialist acts as a consultant in laboratory diagnoses for a broad range of molecular and chromosomal-based disorders, including both inherited and acquired conditions.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000699		
GO:1905937	biolink:BiologicalProcess	negative regulation of germ cell proliferation	Any process that stops, prevents or reduces the frequency, rate or extent of germ cell proliferation.		hp.json	down-regulation of germ cell proliferation|down regulation of germ cell proliferation|inhibition of germ cell proliferation|downregulation of germ cell proliferation	http://purl.obolibrary.org/obo/GO_1905937		
GO:1905938	biolink:BiologicalProcess	positive regulation of germ cell proliferation	Any process that activates or increases the frequency, rate or extent of germ cell proliferation.		hp.json	up regulation of germ cell proliferation|activation of germ cell proliferation|upregulation of germ cell proliferation|up-regulation of germ cell proliferation	http://purl.obolibrary.org/obo/GO_1905938		
OBO:MAXO_0000697	biolink:NamedThing	clinical biochemical geneticist evaluation	An assessment with a specialist who directs and interprets a wide range of specialized, laboratory biochemical genetic analyses relevant to the diagnosis and management of inherited metabolic disorders. The specialist acts as a consultant regarding laboratory diagnosis on a broad range of inborn errors of metabolism.		hp.json	clinical biochemical geneticist consultation|referral to a clinical biochemical geneticist|consultation with clinical biochemical geneticist	http://purl.obolibrary.org/obo/MAXO_0000697		
GO:1905939	biolink:BiologicalProcess	regulation of gonad development	Any process that modulates the frequency, rate or extent of gonad development.		hp.json	regulation of gonadogenesis	http://purl.obolibrary.org/obo/GO_1905939		
OBO:MAXO_0000698	biolink:NamedThing	clinical genetics and genomics specialist evaluation	An assessment with a specialist who provides comprehensive diagnostic, management, therapeutic, and counseling services for individuals and families at risk for clinical disorders with a genetic basis. The specialist is trained to evaluate individuals of all ages for hereditary conditions.		hp.json	clinical genetics and genomics specialist consultation|consultation with clinical genetics and genomics specialist|clinical geneticist evaluation|referral to a clinical geneticist|clinical geneticist consultation|consultation with clinical geneticist	http://purl.obolibrary.org/obo/MAXO_0000698		
OBO:MAXO_0009058	biolink:NamedThing	examination by a neurologist	A direct assessment of a patient's condition by a neurologist that is based on a physical exam, medical history, and the patient's account of symptoms.neurologist.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009058		
OBO:MAXO_0009059	biolink:NamedThing	examination by ob/gyn specialist	A direct assessment of a patient's condition by  an obstetrics and gynecologist specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json	ob/gyn examination|gynecologist examination|obstetrics examination	http://purl.obolibrary.org/obo/MAXO_0009059		
OBO:MAXO_0009056	biolink:NamedThing	examination by emergency medicine specialst	A direct assessment of a patient's condition by an emergency medicine specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json	emergency medicine specialist examination|emergency department physician examination|ED examination|ER examination|emergency room physician examination	http://purl.obolibrary.org/obo/MAXO_0009056		
OBO:MAXO_0009057	biolink:NamedThing	examination by family medicine specialist	A direct assessment of a patient's condition by a family medicine specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009057		
OBO:MAXO_0009054	biolink:NamedThing	examination by immunologist	A direct assessment of a patient's condition by an immunologist that is based on a physical exam, medical history, and the patient's account of symptoms.	NCIT:C74803	hp.json		http://purl.obolibrary.org/obo/MAXO_0009054		
OBO:MAXO_0009055	biolink:NamedThing	examination by dermatologist	A direct assessment of a patient's condition by a dermatologist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json	dermatologist examination	http://purl.obolibrary.org/obo/MAXO_0009055		
OBO:MAXO_0009053	biolink:NamedThing	medical specialist examination	A direct appraisal of a patient's condition by a clinical specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009053		
OBO:MAXO_0009061	biolink:NamedThing	examination by otolaryngologist	A direct appraisal of a patient's condition by an otolaryngologist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009061		
OBO:MAXO_0009062	biolink:NamedThing	examination by orthopedist	A direct appraisal of a patient's condition by an orthopedic specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009062		
GO:1905940	biolink:BiologicalProcess	negative regulation of gonad development	Any process that stops, prevents or reduces the frequency, rate or extent of gonad development.		hp.json	down-regulation of gonad development|down-regulation of gonadogenesis|negative regulation of gonadogenesis|down regulation of gonad development|down regulation of gonadogenesis|downregulation of gonad development|inhibition of gonad development|inhibition of gonadogenesis|downregulation of gonadogenesis	http://purl.obolibrary.org/obo/GO_1905940		
GO:1905941	biolink:BiologicalProcess	positive regulation of gonad development	Any process that activates or increases the frequency, rate or extent of gonad development.		hp.json	up regulation of gonadogenesis|activation of gonadogenesis|positive regulation of gonadogenesis|upregulation of gonad development|upregulation of gonadogenesis|up-regulation of gonad development|up-regulation of gonadogenesis|up regulation of gonad development|activation of gonad development	http://purl.obolibrary.org/obo/GO_1905941		
OBO:MAXO_0009060	biolink:NamedThing	examination by ophthalmologist	A direct appraisal of a patient's condition by a ophthalmologist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json	ophthalmologist examination	http://purl.obolibrary.org/obo/MAXO_0009060		
PR:000050216	biolink:Protein	receptor-type tyrosine-protein phosphatase C isoform CD45R	A receptor-type tyrosine-protein phosphatase C that is a translation product of a transcript that minimally includes the region encoded by the variable exon 4(A).		hp.json	PTPRC/iso:CD45R|CD45R	http://purl.obolibrary.org/obo/PR_000050216		
GO:0002577	biolink:BiologicalProcess	regulation of antigen processing and presentation	Any process that modulates the frequency, rate, or extent of antigen processing and presentation.		hp.json		http://purl.obolibrary.org/obo/GO_0002577		
GO:0002578	biolink:BiologicalProcess	negative regulation of antigen processing and presentation	Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.		hp.json	down-regulation of antigen processing and presentation|down regulation of antigen processing and presentation|inhibition of antigen processing and presentation|downregulation of antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002578		
GO:0002579	biolink:BiologicalProcess	positive regulation of antigen processing and presentation	Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.		hp.json	stimulation of antigen processing and presentation|upregulation of antigen processing and presentation|up-regulation of antigen processing and presentation|up regulation of antigen processing and presentation|activation of antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002579		
GO:0051548	biolink:BiologicalProcess	negative regulation of keratinocyte migration	Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte migration.		hp.json	down regulation of keratinocyte migration|inhibition of keratinocyte migration|down-regulation of keratinocyte migration|downregulation of keratinocyte migration	http://purl.obolibrary.org/obo/GO_0051548		
GO:0002573	biolink:BiologicalProcess	myeloid leukocyte differentiation	The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.		hp.json	myeloid leucocyte differentiation	http://purl.obolibrary.org/obo/GO_0002573		
GO:0051549	biolink:BiologicalProcess	positive regulation of keratinocyte migration	Any process that activates or increases the frequency, rate or extent of keratinocyte migration.		hp.json	upregulation of keratinocyte migration|stimulation of keratinocyte migration|up regulation of keratinocyte migration|activation of keratinocyte migration|up-regulation of keratinocyte migration	http://purl.obolibrary.org/obo/GO_0051549		
GO:0051546	biolink:BiologicalProcess	keratinocyte migration	The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another.		hp.json		http://purl.obolibrary.org/obo/GO_0051546		
GO:0051547	biolink:BiologicalProcess	regulation of keratinocyte migration	Any process that modulates the frequency, rate or extent of keratinocyte migration.		hp.json		http://purl.obolibrary.org/obo/GO_0051547		
GO:0002572	biolink:BiologicalProcess	pro-T cell differentiation	The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.		hp.json	pro-T lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_0002572		
GO:1905952	biolink:BiologicalProcess	regulation of lipid localization	Any process that modulates the frequency, rate or extent of lipid localization.		hp.json	regulation of lipid localisation	http://purl.obolibrary.org/obo/GO_1905952		
GO:1905953	biolink:BiologicalProcess	negative regulation of lipid localization	Any process that stops, prevents or reduces the frequency, rate or extent of lipid localization.		hp.json	down-regulation of lipid localization|downregulation of lipid localisation|down regulation of lipid localisation|inhibition of lipid localisation|downregulation of lipid localization|negative regulation of lipid localisation|down-regulation of lipid localisation|down regulation of lipid localization|inhibition of lipid localization	http://purl.obolibrary.org/obo/GO_1905953		
GO:1905954	biolink:BiologicalProcess	positive regulation of lipid localization	Any process that activates or increases the frequency, rate or extent of lipid localization.		hp.json	upregulation of lipid localization|up-regulation of lipid localisation|activation of lipid localisation|up regulation of lipid localization|up-regulation of lipid localization|upregulation of lipid localisation|activation of lipid localization|positive regulation of lipid localisation|up regulation of lipid localisation	http://purl.obolibrary.org/obo/GO_1905954		
GO:1905955	biolink:BiologicalProcess	negative regulation of endothelial tube morphogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of endothelial tube morphogenesis.		hp.json	downregulation of endothelial tube morphogenesis|down regulation of endothelial tube morphogenesis|inhibition of endothelial tube morphogenesis|down-regulation of endothelial tube morphogenesis	http://purl.obolibrary.org/obo/GO_1905955		
GO:1905956	biolink:BiologicalProcess	positive regulation of endothelial tube morphogenesis	Any process that activates or increases the frequency, rate or extent of endothelial tube morphogenesis.		hp.json	up regulation of endothelial tube morphogenesis|up-regulation of endothelial tube morphogenesis|activation of endothelial tube morphogenesis|upregulation of endothelial tube morphogenesis	http://purl.obolibrary.org/obo/GO_1905956		
GO:0002544	biolink:BiologicalProcess	chronic inflammatory response	Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.		hp.json		http://purl.obolibrary.org/obo/GO_0002544		
HP:0033084	biolink:PhenotypicFeature	Abnormal antral follicle count	Any deviation from a count of antral follicles that is normal for age. Antral follicles appear as small fluid-filled sacs that contain an immature egg. Antral follicle count can be measured (usually on day 2-5 of the menstrual cycle) by transvaginal ultrasound. The number of antral follicles may reflect ovarian reserve.		hp.json		http://purl.obolibrary.org/obo/HP_0033084		
HP:0033083	biolink:PhenotypicFeature	Increased circulating farnesol concentration	An elevated level of farnesol in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033083		
HP:0033086	biolink:PhenotypicFeature	Increased antral follicle count	A count of antral follicles that is higher than normal for age.		hp.json		http://purl.obolibrary.org/obo/HP_0033086		
HP:0033085	biolink:PhenotypicFeature	Reduced antral follicle count	A count of antral follicles that is lower than normal for age.		hp.json		http://purl.obolibrary.org/obo/HP_0033085		
HP:0033080	biolink:PhenotypicFeature	Abnormal TSH response to thyrotrophin-releasing hormone stimulation test	Thyrotrophin-releasing hormone (TRH) is a hypothalamic tripeptide synthesised by, stored within and released from the hypothalamus. It stimulates the synthesis and release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. Following administration of exogenous TRH, a transient increase in serum TSH is expected. This term refers to an abnormal reponse in the TRH stimulation test.		hp.json	Abnormal TSH response to TRH stimulation test	http://purl.obolibrary.org/obo/HP_0033080		
HP:0033082	biolink:PhenotypicFeature	Reduced TSH response to thyrotrophin-releasing hormone stimulation test	A lower than normal TSH response to thyrotrophin-releasing hormone stimulation test.		hp.json		http://purl.obolibrary.org/obo/HP_0033082		
HP:0033081	biolink:PhenotypicFeature	Absent TSH response to thyrotrophin-releasing hormone stimulation test	Failure to increase serum TSH levels in response to a TRH stimulation test.		hp.json		http://purl.obolibrary.org/obo/HP_0033081		
HP:0033088	biolink:PhenotypicFeature	Valinuria	Urine valine level above the normal range.		hp.json	Increased valine in urine	http://purl.obolibrary.org/obo/HP_0033088		
HP:0033087	biolink:PhenotypicFeature	Quotidian fever	Fever that occurs at daily intervals.		hp.json		http://purl.obolibrary.org/obo/HP_0033087		
HP:0033089	biolink:PhenotypicFeature	Branched-chain aminoaciduria	An increased level of a branched chain family amino acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033089		
HP:0045063	biolink:PhenotypicFeature	Increased PIVKA-II	Des-gamma carboxyprothrombin (DCP) or pro-thrombin induced by vitamin K absence-II (PIVKA-II) is an abnormal prothrombin protein that is increased in the serum of patients with HCC. Generation of DCP is thought to be a result of an acquired defect in the post- translational carboxylation of the prothrombin precursor in malignant cells.	UMLS:C1112467	hp.json	Increased prothrombin induced by vitamin K absence-II	http://purl.obolibrary.org/obo/HP_0045063		
HP:0045060	biolink:PhenotypicFeature	Aplasia/hypoplasia involving bones of the extremities		UMLS:C4073181	hp.json		http://purl.obolibrary.org/obo/HP_0045060		
HP:0045061	biolink:PhenotypicFeature	Decreased carnitine level in liver		UMLS:C4073182	hp.json		http://purl.obolibrary.org/obo/HP_0045061		
OBO:MAXO_0000666	biolink:NamedThing	allergy and immunology specialist evaluation	An assessment by an allergist-immunologist who diagnoses and manages disorders involving immune system conditions such as asthma, anaphylaxis, rhinitis and eczema as well as adverse reactions to drugs, foods and insect stings. An allergist-immunologist also manages immune deficiency diseases and problems related to autoimmune disease, organ transplantation or malignancies of the immune system.		hp.json	allergy and immunologist consultation|referral to allergist and immunologist|allergy and immunologist doctor evaluation|allergy and immunologist doctor consultation|consultation with allergist|allergist doctor evaluation|allergy and immunology specialist consultation|allergist evaluation|allergist doctor consultation|allergy and immunologist evaluation|consultation with allergy and immunologist|allergist consultation	http://purl.obolibrary.org/obo/MAXO_0000666		
OBO:MAXO_0000667	biolink:NamedThing	anesthesiology specialist evaluation	An assessment by a physician who provides anesthesia for patients undergoing surgical, obstetric, diagnostic or therapeutic procedures while monitoring the patient's condition and supporting vital organ functions. The anesthesiologist also diagnoses and treats acute, chronic and/or cancer pain as well as provides resuscitation and medical management for patients with critical illnesses and severe injuries.	NCIT:C93067	hp.json	consultation with anesthesiologist|referral to anesthesiologist|anesthesiology doctor evaluation|anesthesiologist evaluation|anesthesiology doctor consultation|anesthesiology specialist consultation|anesthesiologist consultation	http://purl.obolibrary.org/obo/MAXO_0000667		
OBO:MAXO_0000665	biolink:NamedThing	medical specialist evaluation	A procedure where a medical specialtist healthcare provider, who was not previously involved in a patient's treatment, reviews a patient's medical history, examines the patient, and makes recommendations as to care and treatment.		hp.json	specialty medical professional evaluation|specialty medical professional consultation	http://purl.obolibrary.org/obo/MAXO_0000665		
GO:0002548	biolink:BiologicalProcess	monocyte chemotaxis	The movement of a monocyte in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0002548		
OBO:MAXO_0000669	biolink:NamedThing	pediatric anesthesiology specialist evaluation	An evaluation by an anesthesiologist who specializes in Pediatric Anesthesiology. This specialist provides anesthesia for neonates, infants, children and adolescents undergoing surgical, diagnostic or therapeutic procedures as well as appropriate pre- and post-operative care, advanced life support, and acute pain management.		hp.json	consultation with pediatric anesthesiologist|pediatric anesthesiologist evaluation|pediatric anesthesiology specialist consultation|pediatric anesthesiologist consultation	http://purl.obolibrary.org/obo/MAXO_0000669		
GO:0099500	biolink:BiologicalProcess	vesicle fusion to plasma membrane	Fusion of the membrane of a vesicle with the plasma membrane, thereby releasing its contents into the extracellular space.		hp.json		http://purl.obolibrary.org/obo/GO_0099500		
HP:0033095	biolink:PhenotypicFeature	Increased sulfur amino acid level in urine	An elevated level of a sulfur-containing amino acid in the urine.		hp.json	Increased sulfur-containing amino acid level in urine|Increased sulphur amino acid level in urine	http://purl.obolibrary.org/obo/HP_0033095		
GO:0099501	biolink:CellularComponent	exocytic vesicle membrane	The lipid bilayer surrounding an exocytic vesicle.		hp.json	secretory vesicle membrane	http://purl.obolibrary.org/obo/GO_0099501		
HP:0033094	biolink:PhenotypicFeature	Increased urine glutamate level	An increased concentration of glutamate in the urine.		hp.json	Increased glutamic acid in urine	http://purl.obolibrary.org/obo/HP_0033094		
HP:0033097	biolink:PhenotypicFeature	Increased urine proteinogenic amino acid derivative level	An elevated urine level of a compound that is derived from an amino acid.		hp.json		http://purl.obolibrary.org/obo/HP_0033097		
HP:0033096	biolink:PhenotypicFeature	Increased aspartate family amino acid level in urine	An elevated level of an aspartate family amino acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033096		
HP:0033091	biolink:PhenotypicFeature	Tyrosinuria	An abnormally increased level of tyrosine in the urine.		hp.json	Increased tyrosine in urine	http://purl.obolibrary.org/obo/HP_0033091		
HP:0033090	biolink:PhenotypicFeature	Increased aromatic amino acid level in urine	An elevated level of an aromatic amino acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033090		
HP:0033093	biolink:PhenotypicFeature	Increased glutamine family amino acid level in urine	An elevated level of an glutamine family amino acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033093		
HP:0033092	biolink:PhenotypicFeature	Increased urine succinate level	An increase in the level of succinate in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033092		
HP:0033099	biolink:PhenotypicFeature	Increased serine family amino acid in urine	An increased level of a serine family amino acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033099		
HP:0033098	biolink:PhenotypicFeature	Increased urinary non-proteinogenic amino acid level	An increased level in the urine of an alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.		hp.json	Elevated urinary non-proteinogenic amino acid level	http://purl.obolibrary.org/obo/HP_0033098		
HP:0045073	biolink:PhenotypicFeature	Serositis	Inflammation in any serous cavity.		hp.json		http://purl.obolibrary.org/obo/HP_0045073		
HP:0045074	biolink:PhenotypicFeature	Thin eyebrow	Decreased diameter of eyebrow hairs.		hp.json	Thin eyebrow|Thin eyebrows	http://purl.obolibrary.org/obo/HP_0045074		
HP:0045075	biolink:PhenotypicFeature	Sparse eyebrow	Decreased density/number of eyebrow hairs.		hp.json	Hypotrichosis of eyebrow|Sparse eyebrows|Sparse eyebrow	http://purl.obolibrary.org/obo/HP_0045075		hposlim_core
GO:0051560	biolink:BiologicalProcess	mitochondrial calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.		hp.json	mitochondrial calcium ion concentration regulation|calcium ion homeostasis in mitochondria|regulation of calcium ion concentration in mitochondria|regulation of mitochondrial calcium ion concentration|regulation of calcium ion concentration in mitochondrion|calcium ion homeostasis in mitochondrion	http://purl.obolibrary.org/obo/GO_0051560		
HP:0045079	biolink:PhenotypicFeature	Distal femoral metaphyseal irregularity	Irregularity of the normally smooth surface of the distal metaphysis of the femur.		hp.json	Irregular distal femoral metaphyses	http://purl.obolibrary.org/obo/HP_0045079		
GO:0099503	biolink:CellularComponent	secretory vesicle	A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.		hp.json		http://purl.obolibrary.org/obo/GO_0099503		goslim_drosophila
OBO:MAXO_0000680	biolink:NamedThing	internal medicine specialist evaluation	An assessment by a personal physician who provides long-term, comprehensive care in the office and in the hospital, managing both common and complex illnesses of adolescents, adults and the elderly. Internists are trained in the diagnosis and treatment of cancer, infections and diseases affecting the heart, blood, kidneys, joints and the digestive, respiratory and vascular systems. Internists are also trained in the essentials of primary care internal medicine, which incorporates an understanding of disease prevention, wellness, substance abuse, mental health and effective treatment of common problems of the eyes, ears, skin, nervous system and reproductive organs.		hp.json	referral to an internal medicine specialist|consultation with internist|internal medicine specialist consultation|internist evaluation|internist consultation|consultation with internal medicine specialist|referral to an internist	http://purl.obolibrary.org/obo/MAXO_0000680		
GO:0002522	biolink:BiologicalProcess	leukocyte migration involved in immune response	The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.		hp.json	leukocyte trafficking during immune response|immune cell migration during immune response|leucocyte migration during immune response|leucocyte trafficking during immune response|immune cell trafficking during immune response	http://purl.obolibrary.org/obo/GO_0002522		
GO:0002523	biolink:BiologicalProcess	leukocyte migration involved in inflammatory response	The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.		hp.json	leukocyte trafficking during inflammatory response|immune cell migration during inflammatory response|leucocyte migration during inflammatory response|leukocyte migration during inflammatory response|leucocyte trafficking during inflammatory response|immune cell trafficking during inflammatory response	http://purl.obolibrary.org/obo/GO_0002523		
OBO:MAXO_0000681	biolink:NamedThing	adolescent medicine specialist evaluation	An assessment with a multidisciplinary health care specialist trained in the unique physical, psychological and social characteristics of adolescents, their health care problems and needs.		hp.json	evaluation by adolescent medicine specialist|consultation with adolescent medicine specialist|referral to adolescent medicine specialist|adolescent medicine specialist evaluation|adolescent medicine specialist consultation|assessment by adolescent medicine specialist	http://purl.obolibrary.org/obo/MAXO_0000681		
OBO:MAXO_0000684	biolink:NamedThing	critical care medicine internist evaluation	An assessment with an internist trained in critical care medicine who has expertise in the diagnosis, treatment and support of critically ill and injured patients, particularly trauma victims and patients with multiple organ dysfunction.		hp.json	referral to critical care internist|consultation with internal medicine critical care medicine specialist|consultation with critical care medicine internist|internal medicine critical care medicine evaluation|internal medicine critical care medicine consultation	http://purl.obolibrary.org/obo/MAXO_0000684		
OBO:MAXO_0009018	biolink:NamedThing	neuropsychological assessment	Evaluation for cognitive impairment by assessing the neuropsychological domains.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009018		
OBO:MAXO_0000685	biolink:NamedThing	endocrinologist evaluation	An assessment with an internist who specializes in the diagnosis and management of disorders of hormones and their actions, metabolic disorders, and neoplasia of the endocrine glands. This specialist cares for patients with diabetes mellitus, thyroid disorders, disorders of calcium and bone, hyperlipidemia, obesity and nutritional disorders, pituitary disorders, reproductive and gonadal disorders, adrenal diseases, and endocrine hypertension.		hp.json	endocrinology, diabetes and metabolism specialist consultation|consultation with endocrinology, diabetes and metabolism specialist|endocrinologist consultation|referral to endocrinologist|consultation with endocrinologist|endocrinology, diabetes and metabolism specialist evaluation	http://purl.obolibrary.org/obo/MAXO_0000685		
OBO:MAXO_0009019	biolink:NamedThing	language assessment	Evaluation of patient's cominucation involving naming, reading, writing, and repeating words.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009019		
OBO:MAXO_0000682	biolink:NamedThing	cardiovascular disease internist evaluation	An assessment by an internist who specializes in diseases of the heart and blood vessels and manages complex cardiac conditions, such as heart attacks and life-threatening, abnormal heartbeat rhythms.		hp.json	assessment by cardiologist|consultation with internal medicine cardiovascular disease specialist|cardiologist referral|evaluation by cardiologist|consultation with cardiovascular disease internist|internal medicine cardiovascular disease specialist consultation|cardiologist evaluation|referral to cardiovascular disease internist|cardiovascular disease internist evaluation|consultation with cardiologist|referral to cardiologist|cardiologist consultation|cardiovascular disease internist consultation	http://purl.obolibrary.org/obo/MAXO_0000682		
GO:0002520	biolink:BiologicalProcess	immune system development	The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.		hp.json		http://purl.obolibrary.org/obo/GO_0002520		goslim_drosophila
OBO:MAXO_0000683	biolink:NamedThing	clinical cardiac electrophysiologist evaluation	An assessment by a specialist who specializes in intricate technical procedures to evaluate heart rhythms and determine appropriate treatment.		hp.json	consultation with clinical cardiac electrophysiology specialist|internal medicine clinical cardiac electrophysiology specialist evaluation|internal medicine clinical cardiac electrophysiology specialist consultation|referral to a clinical electrophysiologist|internal medicine clinical cardiac electrophysiologist consultation|consultation with clinical cardiac electrophysiologist	http://purl.obolibrary.org/obo/MAXO_0000683		
GO:0002521	biolink:BiologicalProcess	leukocyte differentiation	The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.		hp.json	leucocyte differentiation|immune cell differentiation	http://purl.obolibrary.org/obo/GO_0002521		
OBO:MAXO_0009017	biolink:NamedThing	cognitive assessment	A set of tests or assessments to determine congnitive abilities of a patient.		hp.json	cognitive tests	http://purl.obolibrary.org/obo/MAXO_0009017		
HP:0045090	biolink:PhenotypicFeature	Minor finding	In clinical parlance, findings are occasionally interpreted as being distinctive or minor, reflecting a subjective clinical impression of the importance of a feature for the differential diagnosis. A minor finding is taken to be one that is unlikely to help distinguish the correct diagnosis from other candidates in the differential.		hp.json		http://purl.obolibrary.org/obo/HP_0045090		
HP:0045084	biolink:PhenotypicFeature	Limb myoclonus			hp.json	Myoclonus of limbs	http://purl.obolibrary.org/obo/HP_0045084		
HP:0045085	biolink:PhenotypicFeature	Atrophy of masseter muscle			hp.json	Atrophied masseter muscle|Masseter muscle atrophy	http://purl.obolibrary.org/obo/HP_0045085		
HP:0045086	biolink:PhenotypicFeature	Knee joint hypermobility	The ability of the knee to move past its normal range of motion, (knee hyperextension is greater than 10 degrees).		hp.json	Knee joint over-flexibility	http://purl.obolibrary.org/obo/HP_0045086		
HP:0045087	biolink:PhenotypicFeature	Hip joint hypermobility			hp.json		http://purl.obolibrary.org/obo/HP_0045087		
PR:000001289	biolink:Protein	membrane-spanning 4-domains subfamily A member 1	A protein that is a translation product of the human MS4A1 gene or a 1:1 ortholog thereof.	PIRSF:PIRSF001995|IUPHARobj:2628	hp.json	MS4A1|B-lymphocyte surface antigen B1|B-lymphocyte antigen CD20|B-cell surface antigen CD20|Ly-44|Ms4a2|CD20|lymphocyte antigen 44|leukocyte surface antigen Leu-16|Bp35|B-cell differentiation antigen Ly-44	http://purl.obolibrary.org/obo/PR_000001289		
HP:0045080	biolink:PhenotypicFeature	Decreased proportion of CD3-positive T cells	Any abnormality in the proportion of CD3-positive T cells relative to the total number of T cells.		hp.json	Decreased proportion of CD3+ T cells	http://purl.obolibrary.org/obo/HP_0045080		
HP:0045081	biolink:PhenotypicFeature	Abnormality of body mass index	Anomaly in the weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of obesity and underweight compared to averages.		hp.json	Abnormal BMI|Abnormal body mass index	http://purl.obolibrary.org/obo/HP_0045081		
HP:0045082	biolink:PhenotypicFeature	Decreased body mass index	Abnormally decreased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of underweight compared to averages.		hp.json	Decreased BMI	http://purl.obolibrary.org/obo/HP_0045082		
HP:0045083	biolink:PhenotypicFeature	obsolete Increased body mass index			hp.json		http://purl.obolibrary.org/obo/HP_0045083		
OBO:MAXO_0000688	biolink:NamedThing	hematologist evaluation	An assessment by an internist with additional training who specializes in diseases of the blood, spleen and lymph. This specialist treats conditions such as anemia, clotting disorders, sickle cell disease, hemophilia, leukemia and lymphoma.		hp.json	hematology specialist consultation|hematologist consultation|consultation with hematologist|referral to hematologist|hematology specialist evaluation	http://purl.obolibrary.org/obo/MAXO_0000688		
OBO:MAXO_0000686	biolink:NamedThing	gastroenterologist evaluation	An evaluation with an internist who specializes in diagnosis and treatment of diseases of the digestive organs including the stomach, bowels, liver and gallbladder. This specialist treats conditions such as abdominal pain, ulcers, diarrhea, cancer and jaundice and performs complex diagnostic and therapeutic procedures using endoscopes to visualize internal organs.		hp.json	consultation with gastroenterologist|referral to gastroenterologist|gastroenterologist consultation|gastroenterology specialist evaluation|consultation with gastroenterology specialist	http://purl.obolibrary.org/obo/MAXO_0000686		
HP:0045088	biolink:PhenotypicFeature	Clinical relevance	Subontology for annotating phenotypic features as distinctive or minor findings in patients. The subontology is intended to be used to annotate subjective clinical impressions of whether a certain finding is important for the differential diagnosis.		hp.json		http://purl.obolibrary.org/obo/HP_0045088		
GO:0002526	biolink:BiologicalProcess	acute inflammatory response	Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.		hp.json		http://purl.obolibrary.org/obo/GO_0002526		
HP:0045089	biolink:PhenotypicFeature	Distinctive finding	In clinical parlance, findings are occasionally interpreted as being distinctive or minor, reflecting a subjective clinical impression of the importance of a feature for the differential diagnosis. A minor finding is taken to be one that is likely to have high utility in distinguishing the correct diagnosis from other candidates in the differential.		hp.json		http://purl.obolibrary.org/obo/HP_0045089		
OBO:MAXO_0000670	biolink:NamedThing	colon and rectal surgery specialist evaluation	An assessment by a colon and rectal surgeon who diagnoses and treats various diseases of the small intestine, colon, rectum, anal canal and perianal area including the organs and tissues related with primary intestinal diseases (liver, urinary and female reproductive system). This specialist treats conditions such as hemorrhoids, fissures (painful tears in the anal lining), abscesses and fistulas (infections located around the anus and rectum). A colon and rectal surgeon diagnoses and treats problems of the intestine and colon such as cancer, polyps (precancerous growths) and inflammatory conditions.		hp.json	referral to a colon and rectal surgeon|colon and rectal surgery specialist consultation|colon and rectal surgeon evaluation|colon and rectal surgeon consultation|colorectal surgeon evaluation|consultation with colon and rectal surgery specialist|colorectal surgeon consultation|consultation with colorectal surgeon|referral to colorectal surgeon|consultation with colon and rectal surgeon	http://purl.obolibrary.org/obo/MAXO_0000670		
GO:0002534	biolink:BiologicalProcess	cytokine production involved in inflammatory response	The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.		hp.json	cytokine production involved in acute inflammatory response	http://purl.obolibrary.org/obo/GO_0002534		gocheck_do_not_annotate
OBO:MAXO_0009009	biolink:NamedThing	prenatal renal ultrasonography	The use of ultrasound on a pregnant person to produce images of structures in the kidney of the fetus.		hp.json	fetal kidney ultrsonography|fetal renal ultrasonography|prenatal renal sonography|prenatal kidney ultrasonography	http://purl.obolibrary.org/obo/MAXO_0009009		
GO:0002536	biolink:BiologicalProcess	respiratory burst involved in inflammatory response	A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.		hp.json	respiratory burst involved in acute inflammatory response|oxidative burst during acute inflammatory response|production of reactive oxygen species during acute inflammatory response	http://purl.obolibrary.org/obo/GO_0002536		
OBO:MAXO_0009007	biolink:NamedThing	fetal echocardiography	Fetal echocardiography is a test that uses sound waves (ultrasound) to evaluate the structure and function of the fetus's heart.		hp.json	prenatal echocardiagraphy|prenatal echo procedure|fetal echo procedure|fetal echocardiogram procedure	http://purl.obolibrary.org/obo/MAXO_0009007		
OBO:MAXO_0000673	biolink:NamedThing	family medicine specialist evaluation	An assessment by a physician who provides front-line health care that is accessible, high quality, comprehensive and continuous over time for people of all ages, life stages, backgrounds and conditions. The specialists care for individuals and for entire families, from birth through the end of life, including a broad range of preventive care; healthy lifestyle counseling; mental health care; care of acute illnesses; management of chronic diseases, including patients with multi-morbidity. When needed, they also provide referral and coordination of care with other specialists.		hp.json	family medicine specialist consultation|consultation with family medicine specialist	http://purl.obolibrary.org/obo/MAXO_0000673		
OBO:MAXO_0009008	biolink:NamedThing	Doppler ultrasonography	An application of diagnostic ultrasound used to detect moving blood cells or other moving structures and measure their direction and speed of movement. The Doppler effect is used to evaluate movement by measuring changes in frequency of the echoes reflected from moving structures.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009008		
OBO:MAXO_0000671	biolink:NamedThing	dermatology specialist evaluation	An assessment by a physician with training and expertise in the diagnosis and medical/surgical management of diseases of the skin, hair and nails, and mucous membranes.		hp.json	dermatologist evaluation|referral to a dermatologist|consultation with a dermatologist|dermatologist consultation|dermatology specialist consultation	http://purl.obolibrary.org/obo/MAXO_0000671		
GO:0002532	biolink:BiologicalProcess	production of molecular mediator involved in inflammatory response	The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.		hp.json	production of molecular mediator involved in acute inflammatory response|production of cellular mediator of acute inflammation	http://purl.obolibrary.org/obo/GO_0002532		
OBO:MAXO_0000672	biolink:NamedThing	emergency medicine specialist evaluation	An assessment by a physician who specializes in immediate decision making and action necessary to prevent death or any further disability both in the pre-hospital setting by directing emergency medical technicians and in the emergency department. This specialist provides immediate recognition, evaluation, care, stabilization and disposition of a generally diversified population of adult and pediatric patients in response to acute illness and injury.		hp.json	emergency room doctor evaluation|assessment by emergency medicine specialist|emergency medicine specialist assessment	http://purl.obolibrary.org/obo/MAXO_0000672		
OBO:MAXO_0009006	biolink:NamedThing	clinical whole genome sequencing	A procedure that can determine the DNA sequence for coding and non-coding regions in an individual.		hp.json	WGS|genome sequencing|whole genome sequncing	http://purl.obolibrary.org/obo/MAXO_0009006		
OBO:MAXO_0009003	biolink:NamedThing	preimplantation genetic testing	Genetic testing of one or more cells removed from early embryos conceived by in vitro fertilization and transferring to the mother's uterus only those embryos determined not to have the pathogenic variant(s)/chromosome anomaly(ies) of concern.		hp.json	preimplantation genetic screening|preimplation genetic diagnosis|PGD|PGT|PGS	http://purl.obolibrary.org/obo/MAXO_0009003		
OBO:MAXO_0009004	biolink:NamedThing	clinical whole-exome sequencing	A procedure that can determine the DNA sequence for all of the exons (protein coding region) in an individual.	NCIT:C101295	hp.json	WES|WXS|exome sequencing|whole exome sequencing	http://purl.obolibrary.org/obo/MAXO_0009004		
GO:1903337	biolink:BiologicalProcess	positive regulation of vacuolar transport	Any process that activates or increases the frequency, rate or extent of vacuolar transport.		hp.json	upregulation of vacuolar transport|up regulation of vacuolar transport|up-regulation of vacuolar transport|activation of vacuolar transport	http://purl.obolibrary.org/obo/GO_1903337		
GO:1903336	biolink:BiologicalProcess	negative regulation of vacuolar transport	Any process that stops, prevents or reduces the frequency, rate or extent of vacuolar transport.		hp.json	inhibition of vacuolar transport|down-regulation of vacuolar transport|downregulation of vacuolar transport|down regulation of vacuolar transport	http://purl.obolibrary.org/obo/GO_1903336		
GO:1903335	biolink:BiologicalProcess	regulation of vacuolar transport	Any process that modulates the frequency, rate or extent of vacuolar transport.		hp.json		http://purl.obolibrary.org/obo/GO_1903335		
OBO:MAXO_0000677	biolink:NamedThing	pain medicine specialist evaluation	An assessment by a physician who diagnoses and treats patients experiencing problems with acute or chronic pain, or pain related to cancer, in both hospital and outpatient settings and coordinates care needs with other specialists.		hp.json	assessment by pain medicine specialist|evaluation by pain medicine specialist|consultation with pain medicine specialist|referral to a pain medicine specialist|pain medicine specialist consultation	http://purl.obolibrary.org/obo/MAXO_0000677		
OBO:MAXO_0000678	biolink:NamedThing	sports medicine specialist evaluation	An assesment  a specialist focuses on preventing, diagnosing, and treating injuries related to participating in sports and/or exercise. In addition to the study of those fields that focus on prevention, diagnosis, treatment, and management of injuries, Sports Medicine specialists also deal with illnesses and diseases that might have effects on health and physical performance.		hp.json	consultation with sports medicine specialist|referral to a sports medicine specialist|sports medicine specialist consultation	http://purl.obolibrary.org/obo/MAXO_0000678		
OBO:MAXO_0000675	biolink:NamedThing	geriatric medicine specialist evaluation	An assessment by a physician with special knowledge of the aging process and special skills in the diagnostic, therapeutic, preventive and rehabilitative aspects of illness in the elderly. This specialist cares for geriatric patients in the patient’s home, the office, long-term care settings such as nursing homes, and the hospital.		hp.json	referral to geriatric medicine specialist|consultation with geriatric medicine specialist|evaluation by geriatric medicine specialist|assessment by geriatric medicine specialist|geriatric medicine specialist consultation	http://purl.obolibrary.org/obo/MAXO_0000675		
OBO:MAXO_0000676	biolink:NamedThing	hospice and palliative medicine specialist evaluation	An assessment by a physician who specializes in Hospice and Palliative Medicine who provides care to prevent and relieve the suffering experienced by patients with life-limiting illnesses. This specialist works with an interdisciplinary hospice or palliative care team to optimize quality of life while addressing the physical, psychological, social and spiritual needs of both patient and family.		hp.json	consultation with hospice and palliative medicine specialist|referral to hospice and palliative medicine specialist|evaluation by palliative care specialist|consultation with palliative care specialist|palliative care specialist referral|referral to palliative care specialist|palliative care specialist evaluation|hospice and palliative medicine specialist consultation|palliative care specialist consultation|assessment by palliative care specialist	http://purl.obolibrary.org/obo/MAXO_0000676		
OBO:MAXO_0000679	biolink:NamedThing	sleep medicine specialist evaluation	An assessment with a specialist who has expertise in the diagnosis and management of clinical conditions that occur during sleep, that disturb sleep, or that are affected by disturbances in the wake-sleep cycle. This specialist is skilled in the analysis and interpretation of comprehensive polysomnography, and well versed in emerging research and management of a sleep laboratory.		hp.json	referral to sleep specialist|referral to sleep medicine specialist|consultation with sleep medicine specialist|sleep medicine specialist consultation|evaluation by sleep medicine specialist|sleep specialist assessment|sleep study evaluation|assessment by sleep specialist|sleep specialist referral|assessment by sleep medicine specialist|sleep specialist evaluation|evaluation by sleep specialist|sleep specialist consultation|consultation with sleep specialist	http://purl.obolibrary.org/obo/MAXO_0000679		
HP:0033040	biolink:PhenotypicFeature	Anti-Sm antibody positivity	The presence of autoantibodies in the serum that react to seven proteins that consist of a core of small nuclear ribonucleoprotein (snRNP) particles.		hp.json	Anti-Smith autoantibody	http://purl.obolibrary.org/obo/HP_0033040		
HP:0008083	biolink:PhenotypicFeature	2nd-5th toe middle phalangeal hypoplasia		UMLS:C1861376	hp.json	Underdeveloped 2nd-5th middle toe bones	http://purl.obolibrary.org/obo/HP_0008083		
HP:0033042	biolink:PhenotypicFeature	Abnormal chorion morphology	Any structural anomaly of the fetal part of the placenta, which is known as the chorion.		hp.json		http://purl.obolibrary.org/obo/HP_0033042		
HP:0033041	biolink:PhenotypicFeature	Cytokine storm	Excessive or uncontrolled release of proinflammatory cytokines.		hp.json	Hypercytokinemia	http://purl.obolibrary.org/obo/HP_0033041		
HP:0008080	biolink:PhenotypicFeature	Hallux varus	Medial deviation of the great toe owing to a deformity of the great toe joint causing the hallux to deviate medially.	MSH:D050488|UMLS:C0546297|SNOMEDCT_US:274147008	hp.json	Medially deviated halluces	http://purl.obolibrary.org/obo/HP_0008080		
HP:0008082	biolink:PhenotypicFeature	Medial deviation of the foot		UMLS:C2673401	hp.json		http://purl.obolibrary.org/obo/HP_0008082		
HP:0008081	biolink:PhenotypicFeature	Pes valgus	An outward deviation of the foot at the talocalcaneal or subtalar joint.	SNOMEDCT_US:249803006|SNOMEDCT_US:275344002|UMLS:C1578482	hp.json	Valgus foot deformity	http://purl.obolibrary.org/obo/HP_0008081		
HP:0033048	biolink:PhenotypicFeature	Substantia nigra hypointensity on susceptibility-weighted imaging	Hypointence (dark) appearance of the substantia nigra inmagnetic resonance imaging using susceptibility weighted imaging (SWI).		hp.json	Low signal intensity in the substantia nigra on susceptibility-weighted imaging (SWI)	http://purl.obolibrary.org/obo/HP_0033048		
HP:0033047	biolink:PhenotypicFeature	Body ache	Body ache is a complaint that is often used to denote vague symptoms of mild fatigue, lethargy, or dull aches. We will define it here to mean a dull and poorly localizable pain that is described by the affected individual to affect multiple joints or body parts or even the entire body.		hp.json		http://purl.obolibrary.org/obo/HP_0033047		
HP:0033049	biolink:PhenotypicFeature	Globus pallidus hypointensity on susceptibility-weighted imaging	Hypointence (dark) appearance of the globus pallidus inmagnetic resonance imaging using susceptibility weighted imaging (SWI).		hp.json		http://purl.obolibrary.org/obo/HP_0033049		
HP:0033044	biolink:PhenotypicFeature	Motor regression	Loss of previously achieved motor skills, as manifested by loss of developmental motor milestones.		hp.json	Regression of motor skills	http://purl.obolibrary.org/obo/HP_0033044		
HP:0033043	biolink:PhenotypicFeature	Edematous chorionic villi	Swelling of the chorionic villi owing to fluid accumulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033043		
HP:0033046	biolink:PhenotypicFeature	Michaelis-Gutmann bodies	Basophilic intracytoplasmic inclusions in macrophages. The inclusions have a small, round laminated appearance. Electron microscopy of Michaelis-Gutmann bodies exhibits partially digested bacteria.		hp.json	Malakoplakia	http://purl.obolibrary.org/obo/HP_0033046		
HP:0033045	biolink:PhenotypicFeature	Bipedal edema	A palpable swelling in both feet and ankles caused by palpable swelling caused by an increase in interstitial fluid volume (excess fulid).		hp.json	Bipedal oedema	http://purl.obolibrary.org/obo/HP_0033045		
HP:0045026	biolink:PhenotypicFeature	Abnormality of the mediastinum		UMLS:C4022395	hp.json		http://purl.obolibrary.org/obo/HP_0045026		
HP:0045027	biolink:PhenotypicFeature	Abnormality of the thoracic cavity		UMLS:C4022394	hp.json		http://purl.obolibrary.org/obo/HP_0045027		
HP:0045028	biolink:PhenotypicFeature	Microlissencephaly	Severe microcephaly and lissencephaly with granular surfaces with immature cortical plate, reduced in thickness, with focal polymicrogyria and immature small neurons with rare processes, intermingled with a considerable number of glial elements.	UMLS:C4021030	hp.json	Type 3 lissencephaly|Lissencephaly type III|Type III lissencephaly	http://purl.obolibrary.org/obo/HP_0045028		
HP:0045029	biolink:PhenotypicFeature	Eosinophilic fasciitis	Inflammation and thickening (localized fibrosis) of the fascia, the tissue under the skin and over the muscle, typically associated with a build up of eosinophils in the muscles and tissues.	MSH:C562487|UMLS:C0264005|SNOMEDCT_US:24129002	hp.json		http://purl.obolibrary.org/obo/HP_0045029		
HP:0008076	biolink:PhenotypicFeature	Osteoporotic tarsals	Reduction in bone mineral density affecting any or all of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.	UMLS:C1836872	hp.json		http://purl.obolibrary.org/obo/HP_0008076		
HP:0008079	biolink:PhenotypicFeature	Absent fifth metatarsal	A developmental abnormality characterized by the absence of the fifth metatarsal bone.	UMLS:C1867932	hp.json	Aplasia of the fifth metatarsal bone|Absent 5th long bone of foot|Absent 5th metatarsals	http://purl.obolibrary.org/obo/HP_0008079		
HP:0045025	biolink:PhenotypicFeature	Narrow palpebral fissure	Reduction in the vertical distance between the upper and lower eyelids.	UMLS:C2675021|UMLS:C1837464	hp.json	Small opening between the eyelids|Small palpebral fissures|Decreased size of palpebral fissure|Narrow palpebral fissures|Narrow eyelid opening	http://purl.obolibrary.org/obo/HP_0045025		
HP:0008078	biolink:PhenotypicFeature	Thin metatarsal cortices		UMLS:C1850162	hp.json		http://purl.obolibrary.org/obo/HP_0008078		
HP:0008095	biolink:PhenotypicFeature	Osteolysis of talus	Osteolysis affecting the talus.	UMLS:C4021556	hp.json	Osteolysis of tali	http://purl.obolibrary.org/obo/HP_0008095		
HP:0033051	biolink:PhenotypicFeature	Impaired executive functioning	A disturbance of executive functioning, which is broadly defined as the set of abilities that allow for the planning, executing, monitoring, and self-correcting of goal-directed behavior while inhibiting task-irrelevant behavior. At least some degree of executive skill is needed to complete most cognitive tasks, and deficits in executive abilities are central to many clinical conditions, including fronto-temporal dementia.		hp.json		http://purl.obolibrary.org/obo/HP_0033051		
HP:0033050	biolink:PhenotypicFeature	Pharyngalgia	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the throat.		hp.json	Throat discomfort|Pharyngodynia|Sore throat|Throat pain	http://purl.obolibrary.org/obo/HP_0033050		
HP:0008094	biolink:PhenotypicFeature	Widely spaced toes	An overall widening of the spaces between the digits.	UMLS:C1969238	hp.json	Widely spaced toes	http://purl.obolibrary.org/obo/HP_0008094		
HP:0008097	biolink:PhenotypicFeature	Partial fusion of tarsals		UMLS:C1844520	hp.json		http://purl.obolibrary.org/obo/HP_0008097		
HP:0033053	biolink:PhenotypicFeature	Pseudoseizure	Sudden, involuntary seizure-like attacks that, unlike epileptic seizures, are not related to electrographic ictal discharges.		hp.json		http://purl.obolibrary.org/obo/HP_0033053		
HP:0008096	biolink:PhenotypicFeature	Medially deviated second toe	Medial deviation of the second toe.	UMLS:C1862147	hp.json		http://purl.obolibrary.org/obo/HP_0008096		
HP:0033052	biolink:PhenotypicFeature	Psychogenic non-epileptic seizure	Psychogenic non-epileptic seizures (PNES) are an important cause of apparently treatment-resistant epilepsy and remain a major diagnostic challenge in epileptology. The two main PNES groups are panic disorder (also occurring as a reaction in people with epilepsy) and dissociative disorder (pseudoseizure), often developing inpatients with no history of epilepsy. The main markers distinguishing PNES from epileptic seizures are (i) the way the patient tells the story (not focusing on the seizure symptoms, avoidance of the word seizure, etc); (ii) that they are prolonged (many minutes); (iii) associated with hyperventilation and eyes closed; and that they present as treatment-resistant epilepsy despite an often normal intellect and brain imaging.		hp.json		http://purl.obolibrary.org/obo/HP_0033052		
HP:0008090	biolink:PhenotypicFeature	Ankylosis of feet small joints		UMLS:C4024732	hp.json		http://purl.obolibrary.org/obo/HP_0008090		
HP:0008093	biolink:PhenotypicFeature	Short 4th toe	Underdevelopment (hypoplasia) of the fourth toe.	UMLS:C1862083	hp.json	Short 4th toe|Short fourth toe	http://purl.obolibrary.org/obo/HP_0008093		
HP:0033059	biolink:PhenotypicFeature	Decreased serum complement C6	A reduced level of the complement component C6 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033059		
HP:0033058	biolink:PhenotypicFeature	Decreased serum complement C7	A reduced level of the complement component C7 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033058		
HP:0033055	biolink:PhenotypicFeature	Impaired ability to plan	Impaired ability to anticipate future events, implement instructions or goals, and develop appropriate steps ahead of time in order to carry out a task or activity.		hp.json	Ineffective planning	http://purl.obolibrary.org/obo/HP_0033055		
HP:0033054	biolink:PhenotypicFeature	Myoclonic tremor	A tremor-like cortical myoclonus. The tremulous movements are in fact small, high-frequency myoclonic jerks, induced by posture or action. They can be mild, but can also be more incapacitating. When present in the lower limbs, these may lead to gait disorders and even drop attacks. These tremor-like movements during action can be mistaken for essential tremor or epileptic seizures.		hp.json		http://purl.obolibrary.org/obo/HP_0033054		
HP:0033057	biolink:PhenotypicFeature	Decreased serum terminal complement component	Reduced level of one or more components of the the terminal membrane attack complex (MAC) portion of complement, which represents the lytic, pore-forming part of the system. The MAC comprises seven components: C5b, C6, C7, C8 (a heterotrimer composed of C8alpha, C8beta and C8gamma) and multiple copies of C9.		hp.json		http://purl.obolibrary.org/obo/HP_0033057		
HP:0033056	biolink:PhenotypicFeature	Impaired ability to organize	Impaired ability to bring order to information, actions, or materials to achieve a goal or to follow an established organized routine.		hp.json	Impaired ability to organise	http://purl.obolibrary.org/obo/HP_0033056		
OBO:MAXO_0000617	biolink:NamedThing	pulse oximetry	A non-invasive method that provides estimates of arterial oxyhemoglobin saturation by utilizing selected wavelengths of light to determine the saturation of oxyhemoglobin.	NCIT:C38085	hp.json	pulse ox measurement	http://purl.obolibrary.org/obo/MAXO_0000617		
OBO:MAXO_0000611	biolink:NamedThing	rapid IgM-IgG combined antibody testing	A type of lateral flow assay that qualitatively detect IgG and IgM antibodies of an infectious disease within human serum, plasma or whole blood in vitro.		hp.json	rapid IgM-IgG testing	http://purl.obolibrary.org/obo/MAXO_0000611		
HP:0045037	biolink:PhenotypicFeature	Abnormality of jaw muscles		UMLS:C4073166	hp.json	Abnormality of jaw muscles	http://purl.obolibrary.org/obo/HP_0045037		
HP:0045038	biolink:PhenotypicFeature	Gastric lymphoma	Lymphoma that originates in the stomach itself.	SNOMEDCT_US:276811008|UMLS:C0349532|MSH:C535648	hp.json	Primary gastric lymphoma	http://purl.obolibrary.org/obo/HP_0045038		
OBO:MAXO_0000612	biolink:NamedThing	clinical lateral flow assay testing	A procedure using a paper-based platform for the detection and quantification of analytes in complex mixtures, where the sample is placed on a test device for clinical use.		hp.json	lateral flow immunoassay|LFA testing|lateral flow immuno assay	http://purl.obolibrary.org/obo/MAXO_0000612		
HP:0045039	biolink:PhenotypicFeature	Osteolysis involving bones of the upper limbs		UMLS:C4073167	hp.json		http://purl.obolibrary.org/obo/HP_0045039		
OBO:MAXO_0000610	biolink:NamedThing	clinical ELISA testing	A highly sensitive technique for detecting and measuring antigens or antibodies in a solution; the solution is run over a surface to which immobilized antibodies specific to the substance have been attached, and if the substance is present, it will bind to the antibody layer, and its presence is verified and visualized with an application of antibodies that have been tagged in some way. (BioTech Life Science Dictionary)	OBI:0000661|NCIT:C16553	hp.json	enzyme-linked immunosorbent assay|enzyme linked immunosorbent assay testing	http://purl.obolibrary.org/obo/MAXO_0000610		
OBO:MAXO_0000615	biolink:NamedThing	clinical immunoblot assay testing	A technique for analyzing or identifying proteins immobilized on a filter by complementary reaction with specific antibodies.	NCIT:C17638|OBI:0001978	hp.json	clinical Western blot assay	http://purl.obolibrary.org/obo/MAXO_0000615		
HP:0045034	biolink:PhenotypicFeature	Elevated urinary aminoisobutyric acid	An increased amount of 3-aminoisobutyric acid in the urine.	UMLS:C4022393	hp.json		http://purl.obolibrary.org/obo/HP_0045034		
OBO:MAXO_0000616	biolink:NamedThing	oxygen saturation measurement	The measurement of the ratio of oxygenated hemoglobin to total hemoglobin in the blood.	NCIT:C60832	hp.json		http://purl.obolibrary.org/obo/MAXO_0000616		
HP:0008087	biolink:PhenotypicFeature	Nonossified fifth metatarsal	The presence of a fifth metatarsal bone that has not undergone ossification at an age when ossification is usually visible.	UMLS:C1844712	hp.json		http://purl.obolibrary.org/obo/HP_0008087		
HP:0045035	biolink:PhenotypicFeature	Decreased urinary copper concentration		UMLS:C4073164	hp.json	Decreased urinary copper concentration	http://purl.obolibrary.org/obo/HP_0045035		
OBO:MAXO_0000613	biolink:NamedThing	clinical immunoassay	Any of several immunoassay methods that use an enzyme covalently linked to an antigen or antibody as a label and are typically used for diagnostics or disease progression.	NCIT:C17455	hp.json		http://purl.obolibrary.org/obo/MAXO_0000613		
HP:0008089	biolink:PhenotypicFeature	Abnormality of the fifth metatarsal bone	An anomaly of the fifth metatarsal bone.	UMLS:C4024733	hp.json	Abnormality of the 5th long bone of foot	http://purl.obolibrary.org/obo/HP_0008089		
OBO:MAXO_0000614	biolink:NamedThing	clinical immunofluorescence assay testing	Immunofluorescence staining used in a pathology or clinical lab to diagnose diseases of the skin, kidney, heart, cilia and other organ systems.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000614		
HP:0045036	biolink:PhenotypicFeature	Abnormal urinary copper concentration		UMLS:C4073165	hp.json	Abnormal urinary copper concentration	http://purl.obolibrary.org/obo/HP_0045036		
HP:0033062	biolink:PhenotypicFeature	Abnormal factor IX activity	Abnormal activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa.		hp.json		http://purl.obolibrary.org/obo/HP_0033062		
HP:0008062	biolink:PhenotypicFeature	Aplasia/Hypoplasia affecting the anterior segment of the eye	Absence or underdevelopment of the anterior segment of the eye.	UMLS:C4024739	hp.json		http://purl.obolibrary.org/obo/HP_0008062		
HP:0008061	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the retina		UMLS:C4024740	hp.json	Absent/underdeveloped retina|Absent/small retina	http://purl.obolibrary.org/obo/HP_0008061		
HP:0033061	biolink:PhenotypicFeature	Increased factor IX activity	Elevated activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa.		hp.json		http://purl.obolibrary.org/obo/HP_0033061		
HP:0008064	biolink:PhenotypicFeature	Ichthyosis	An abnormality of the skin characterized the presence of excessive amounts of dry surface scales on the skin resulting from an abnormality of keratinization.	MEDDRA:10021198|MSH:D007057|UMLS:C0020757	hp.json	Ichthyosiform abnormality of the skin|Hypertrophic ichthyosis|Ichthyotic skin	http://purl.obolibrary.org/obo/HP_0008064		hposlim_core
HP:0033064	biolink:PhenotypicFeature	Renal interstitial globotriaosylceramide inclusions	Accumulation of globotriaosylceramide (GL-3) in kidney tissues, which can be quantified as the number of globotriaosylceramide (GL-3) inclusions/kidney interstitial capillary (KIC).		hp.json		http://purl.obolibrary.org/obo/HP_0033064		
HP:0008063	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the lens	Absence or underdevelopment of the lens.	UMLS:C4024738	hp.json	Absent/underdeveloped lens|Absent/small lens	http://purl.obolibrary.org/obo/HP_0008063		
HP:0033063	biolink:PhenotypicFeature	Shortened sleep cycle	A tendency to sleep less hours than usual while feeling well rested.		hp.json	Short sleep	http://purl.obolibrary.org/obo/HP_0033063		
HP:0008060	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the fovea	Congenital absence or underdevelopment of the fovea centralis.	UMLS:C4024741	hp.json	Absent/underdeveloped fovea	http://purl.obolibrary.org/obo/HP_0008060		
HP:0033060	biolink:PhenotypicFeature	Decreased serum complement C5	A reduced level of the complement component C5 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033060		
CHEBI:63473	biolink:ChemicalSubstance	aromatic amino-acid anion	An aromatic amino acid whose alpha-carboxylic acid group is ionized (non-protonated).		hp.json	aromatic amino-acid anions	http://purl.obolibrary.org/obo/CHEBI_63473		3_STAR
HP:0033069	biolink:PhenotypicFeature	Renal interstitial IgG4+ plasma cell infiltration	An increased number of IgG4+ plasma cells in the interstitial space of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033069		
CHEBI:63471	biolink:ChemicalSubstance	branched-chain amino-acid anion	A branched-chain amino acid whose alpha-carboxylic acid group is ionized.		hp.json	branched-chain amino-acid anions	http://purl.obolibrary.org/obo/CHEBI_63471		3_STAR
CHEBI:63470	biolink:ChemicalSubstance	sulfur-containing amino-acid anion	A sulfur-containing amino acid whose alpha-carboxylic acid group is ionized (not protonated).		hp.json	sulfur-containing amino-acid anions	http://purl.obolibrary.org/obo/CHEBI_63470		3_STAR
CHEBI:63477	biolink:ChemicalSubstance	iodothyroninate	An iodothyronine whose alpha carboxylic acid group of the tyrosine is ionized (not protonated).		hp.json	iodothyroninates	http://purl.obolibrary.org/obo/CHEBI_63477		3_STAR
HP:0033066	biolink:PhenotypicFeature	Severe albuminuria	The presence of severely increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio greater than 300 mg/gm (greater than 34 mg/mmol).		hp.json	Heavy albuminuria	http://purl.obolibrary.org/obo/HP_0033066		
HP:0033065	biolink:PhenotypicFeature	Mild albuminuria	The presence of mildly increased concentrations of albumin in the urine, defined as an albumin-creatinine ratio (ACR) less than 30 mg/gm (less than 3.4 mg/mmol).		hp.json		http://purl.obolibrary.org/obo/HP_0033065		
HP:0033068	biolink:PhenotypicFeature	Medication crystalluria	A variety of drugs may occasionally cause transient crystalluria, in isolation or in conjunction with other urinary abnormalities. Overdose, dehydration, or hypoalbuminaemia, which increases the unbound drug which is ultrafiltrated by the glomerulus, are the factors usally favoring the precipitation of crystals within the tubular lumina. In some cases, medication-induced crystalluria has a distinct phenotypic appearance. For instance, Sulphadiazine crystals appear as strongly birefringent 'shocks of wheat' or 'shells' with an amber colour. Acyclovir crystals are birefringent and needle-shaped, and when present in abundance give to urine a silky and opalescent macroscopic appearance.		hp.json		http://purl.obolibrary.org/obo/HP_0033068		
HP:0033067	biolink:PhenotypicFeature	Cystine crystalluria			hp.json		http://purl.obolibrary.org/obo/HP_0033067		
HP:0045040	biolink:PhenotypicFeature	Abnormal lactate dehydrogenase level	A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate.	UMLS:C4073168	hp.json		http://purl.obolibrary.org/obo/HP_0045040		
HP:0045041	biolink:PhenotypicFeature	Reduced lactate dehydrogenase B level	A decreased or reduced level of the enzyme lactate dehydrogenase in serum.	UMLS:C3279904|MSH:C563641	hp.json		http://purl.obolibrary.org/obo/HP_0045041		
HP:0045042	biolink:PhenotypicFeature	Decreased serum complement C4	A reduced level of the complement component C4 in the circulation.	UMLS:C4073169	hp.json	Decreased serum complement C4 level	http://purl.obolibrary.org/obo/HP_0045042		
HP:0045043	biolink:PhenotypicFeature	Decreased serum complement C4a	A reduced level of the complement component C4a in circulation.	UMLS:C4073170	hp.json	Complement component 4A deficiency|C4a deficiency	http://purl.obolibrary.org/obo/HP_0045043		
HP:0045048	biolink:PhenotypicFeature	Increased HbA2 hemoglobin	An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia.	UMLS:C4073172	hp.json	Increased hemoglobin A2|Increased HbA2 haemoglobin|Increased haemoglobin A2	http://purl.obolibrary.org/obo/HP_0045048		
HP:0008059	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the macula		UMLS:C4024742	hp.json	Absent/underdeveloped macula	http://purl.obolibrary.org/obo/HP_0008059		
HP:0045049	biolink:PhenotypicFeature	Abnormal DLCO	An abnormal amount of oxygen passes into the blood from the lungs and/or an abnormal amount of carbon dioxide passes from the blood into the lungs.	UMLS:C4073173	hp.json	Abnormal transfer factor of the lung for carbon monoxide|Abnormal diffusing capacity|Abnormal TLCO	http://purl.obolibrary.org/obo/HP_0045049		
HP:0008058	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the optic nerve		UMLS:C4024743	hp.json	Absent/small optic nerve|Absent/underdeveloped optic nerve	http://purl.obolibrary.org/obo/HP_0008058		
HP:0045044	biolink:PhenotypicFeature	Decreased serum complement C4b	A reduced level of the complement component C4b in circulation.	UMLS:C3280641	hp.json	C4b deficiency|Complement component 4B deficiency	http://purl.obolibrary.org/obo/HP_0045044		
HP:0008055	biolink:PhenotypicFeature	Aplasia/Hypoplasia affecting the uvea	Absence or underdevelopment of the uvea, the pigmented middle layer of the eye consisting of the iris and ciliary body together with the choroid.	UMLS:C4024746	hp.json	Absent/underdeveloped uvea	http://purl.obolibrary.org/obo/HP_0008055		
HP:0008054	biolink:PhenotypicFeature	Abnormal morphology of the conjunctival vasculature	Any abnormality of the blood vessels of the conjunctiva.	UMLS:C4024747	hp.json	Abnormality of the vasculature of the conjunctiva|Abnormal vasculature of the conjunctiva morphology|Abnormal morphology of the conjunctiva vasculature	http://purl.obolibrary.org/obo/HP_0008054		
HP:0045045	biolink:PhenotypicFeature	Elevated circulating acylcarnitine concentration	An abnormally increased concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine.	UMLS:C4073171	hp.json	Elevated plasma acylcarnitine levels	http://purl.obolibrary.org/obo/HP_0045045		
HP:0008057	biolink:PhenotypicFeature	Aplasia/Hypoplasia affecting the fundus		UMLS:C4024744	hp.json	Absent/small fundus	http://purl.obolibrary.org/obo/HP_0008057		
HP:0045046	biolink:PhenotypicFeature	Reduced insulin like growth factor binding protein acid labile subunit concentration	An abnormally decreased concentration of insulin like growth factor binding protein acid labile subunit level in the blood circulation.	UMLS:C3900122	hp.json	Acid-labile subunit deficiency|Reduced insulin like growth factor binding protein acid labile subunit level|Decreased levels of acid labile subunit	http://purl.obolibrary.org/obo/HP_0045046		
HP:0008056	biolink:PhenotypicFeature	Aplasia/Hypoplasia affecting the eye		UMLS:C4024745	hp.json	Absent/underdeveloped eye|Absent/small eye	http://purl.obolibrary.org/obo/HP_0008056		
HP:0045047	biolink:PhenotypicFeature	HbS hemoglobin	Presence of an abnormal type of hemoglobin characterized by the subsitution of a glutamic acid residue at position 7 following the initial methionine residue by a valine (the mutation causative of sickle cell disease). The mutation promotes the polymerization of the HbS under conditions of low oxygen concentration. HbS can be identified by multiple methodologies including hemoglobin electrophoresis and high-performance liquid chromatography.	MSH:D006451|UMLS:C0019043|SNOMEDCT_US:50095005	hp.json	HbS haemoglobin	http://purl.obolibrary.org/obo/HP_0045047		
HP:0008073	biolink:PhenotypicFeature	Low maternal circulating estriol concentration	An abnormally low concentration of serum conjugated estriol as compared to normal values for gestational-age.	UMLS:C4024734	hp.json	Low maternal serum estriol	http://purl.obolibrary.org/obo/HP_0008073		
HP:0033073	biolink:PhenotypicFeature	Urate tophus	Intradermal urate crystal deposits appeared as small, superficial, pustule-like, whitish lesions. The lesions may be the focus of inflammatory episodes with increasing pain, swelling, and erythema of the intradermal tophi.		hp.json	Urate tophi	http://purl.obolibrary.org/obo/HP_0033073		
HP:0033072	biolink:PhenotypicFeature	Abnormal macroscopic urine appearance	Anomalous physical appearance (color, cloudiness, clarity) or odor of urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033072		
HP:0008072	biolink:PhenotypicFeature	Maternal virilization in pregnancy	Virilization (deepening of voice, facial hirsutism and scalp hair loss) with onset during pregnancy (usually towards the end of the first trimester) and regression several months post-partum.	UMLS:C4024735	hp.json		http://purl.obolibrary.org/obo/HP_0008072		
HP:0008075	biolink:PhenotypicFeature	Progressive pes cavus	The development of Pes cavus that is progressive with age.	UMLS:C1846017	hp.json		http://purl.obolibrary.org/obo/HP_0008075		
HP:0033075	biolink:PhenotypicFeature	Inappropriately normal thyroid-stimulating hormone level	A normal or elevated serum thyroid-stimulating hormone (TSH) level in the face of an elevation in circulating FT4 and/or FT3.		hp.json	Inappropriately normal TSH	http://purl.obolibrary.org/obo/HP_0033075		
HP:0008074	biolink:PhenotypicFeature	Metatarsal periosteal thickening		UMLS:C1834349	hp.json		http://purl.obolibrary.org/obo/HP_0008074		
HP:0033074	biolink:PhenotypicFeature	Steroid-responsive anemia	Amelioration of anemia upon treatment with a steroid medication.		hp.json	Prednisone-responsive anemia|Steroid-responsive anaemia|Prednisone-responsive anaemia	http://purl.obolibrary.org/obo/HP_0033074		
HP:0008071	biolink:PhenotypicFeature	Maternal hypertension	Increased blood pressure during a pregnancy.	UMLS:C0565599|SNOMEDCT_US:288250001	hp.json		http://purl.obolibrary.org/obo/HP_0008071		
HP:0033071	biolink:PhenotypicFeature	Impaired task monitoring	Impaired ability to keep track of one's problem-solving success or failure, and to identify and correct mistakes during performance of a goal.		hp.json		http://purl.obolibrary.org/obo/HP_0033071		
HP:0008070	biolink:PhenotypicFeature	Sparse hair	Reduced density of hairs.	UMLS:C1837770|MSH:D007039|MEDDRA:10021126|SNOMEDCT_US:56558005|UMLS:C0020678|UMLS:C1860844|SNOMEDCT_US:53602002	hp.json	Decreased hair growth on body|Hypotrichosis|Sparse hair since birth|Decreased hair growth|Marked hypotrichosis|Sparse hair|Thin, sparse hair	http://purl.obolibrary.org/obo/HP_0008070		hposlim_core
HP:0033070	biolink:PhenotypicFeature	Impaired self monitoring	Impaired ability to track awareness of the effect that one's behavior has on others and how it compares with standards or expectations for behavior.		hp.json		http://purl.obolibrary.org/obo/HP_0033070		
HP:0033077	biolink:PhenotypicFeature	Increased circulating free T4 concentration	An elevated concentration of free thyroxine (fT4) in the blood circulation.		hp.json	Increased circulating free T4 level	http://purl.obolibrary.org/obo/HP_0033077		
HP:0033076	biolink:PhenotypicFeature	Abnormal circulating free T4 concentration	A deviation from the normal concentration of free thyroxine (T4) in the blood circulation. Circulating T4 is almost entirely bound to specific transport proteins such as thyroxine-binding globulin (TBG) but it is the unbound (free) fraction that is able to enter tissues and exert effects.		hp.json	Abnormal circulating free thyroxine level|Abnormal circulating free T4 level	http://purl.obolibrary.org/obo/HP_0033076		
HP:0033079	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the thyroid gland	Absence or underdevelopment of the thyroid gland.		hp.json		http://purl.obolibrary.org/obo/HP_0033079		
HP:0033078	biolink:PhenotypicFeature	Decreased circulating free T4 concentration	A reduced concentration of free thyroxine (fT4) in the blood circulation.		hp.json	Decreased circulating free T4 level	http://purl.obolibrary.org/obo/HP_0033078		
HP:0045051	biolink:PhenotypicFeature	Decreased DLCO	Reduced ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test.	UMLS:C4073175	hp.json	Decreased diffusing capacity	http://purl.obolibrary.org/obo/HP_0045051		
HP:0045052	biolink:PhenotypicFeature	Abnormality of the brachial nerve plexus	Any abnormality of the brachial nerve plexus.	UMLS:C4073176	hp.json		http://purl.obolibrary.org/obo/HP_0045052		
HP:0045053	biolink:PhenotypicFeature	Abnormality of the lumbosacral nerve plexus	Any abnormality of the lumbosacral nerve plexus.	UMLS:C4073177	hp.json		http://purl.obolibrary.org/obo/HP_0045053		
HP:0045054	biolink:PhenotypicFeature	Brachial plexus neuropathy		SNOMEDCT_US:3548001|UMLS:C0700251|MSH:D020516	hp.json		http://purl.obolibrary.org/obo/HP_0045054		
OIO:logical-definition-view-relation	biolink:NamedThing	logical-definition-view-relation			hp.json		http://www.geneontology.org/formats/oboInOwl#logical-definition-view-relation		
HP:0045050	biolink:PhenotypicFeature	Increased DLCO	Increased ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test.	UMLS:C4073174	hp.json	Increased diffusing capacity	http://purl.obolibrary.org/obo/HP_0045050		
HP:0045059	biolink:PhenotypicFeature	Hyperkeratotic papule	A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point that is composed of localized hyperkeratosis (the latter may be demonstrated histopathologically).	UMLS:C2047516	hp.json		http://purl.obolibrary.org/obo/HP_0045059		
HP:0008069	biolink:PhenotypicFeature	Neoplasm of the skin	A tumor (abnormal growth of tissue) of the skin.	SNOMEDCT_US:372130007|SNOMEDCT_US:126488004|UMLS:C0007114|MSH:D012878|UMLS:C0037286|NCIT:C3262	hp.json	Skin tumours|Skin cancer|Skin tumors|Neoplasia of the skin|Dermatological tumours|Dermatological tumors|Tumor of the skin|Skin cancer (non-melanoma)|Tumour of the skin	http://purl.obolibrary.org/obo/HP_0008069		hposlim_core
HP:0008066	biolink:PhenotypicFeature	Abnormal blistering of the skin	The presence of one or more bullae on the skin, defined as fluid-filled blisters more than 5 mm in diameter with thin walls.	UMLS:C2220104|UMLS:C2132198|UMLS:C0241054	hp.json	Blisters|Blister|Skin bullae|Abnormal blistering of the skin|Blistering, generalised|Blistering, generalized|Skin blisters	http://purl.obolibrary.org/obo/HP_0008066		
HP:0045055	biolink:PhenotypicFeature	Tiger tail banding	An abnormal appearance of hair under polarizing microscopy (using crossed polarizers), whereby hair shafts show striking alternating bright and dark bands, often referred to as tiger tail banding.	UMLS:C4073178	hp.json	Tiger tail banding|Tiger-tail banding	http://purl.obolibrary.org/obo/HP_0045055		
HP:0045056	biolink:PhenotypicFeature	Abnormal levels of alpha-fetoprotein		UMLS:C4073179	hp.json		http://purl.obolibrary.org/obo/HP_0045056		
HP:0008065	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the skin		UMLS:C4024737	hp.json	Absent/underdeveloped skin|Absent/small skin	http://purl.obolibrary.org/obo/HP_0008065		
HP:0045057	biolink:PhenotypicFeature	Decreased levels of alpha-fetoprotein	A decrease in the concentration of alpha-fetoprotein in the blood circulation.	UMLS:C4073295	hp.json		http://purl.obolibrary.org/obo/HP_0045057		
HP:0045058	biolink:PhenotypicFeature	Abnormality of the testis size	An anomaly of the size of the testicle (the male gonad).	UMLS:C4073180	hp.json		http://purl.obolibrary.org/obo/HP_0045058		
HP:0008067	biolink:PhenotypicFeature	Abnormally lax or hyperextensible skin		UMLS:C4024736	hp.json	Abnormally loose or hyperelastic skin|Abnormally loose or stretchable skin	http://purl.obolibrary.org/obo/HP_0008067		
HP:0033004	biolink:PhenotypicFeature	Palmar warts	Multiple verrucous lesions on the skin of the palm. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by caused by human papillomavirus (HPV).		hp.json		http://purl.obolibrary.org/obo/HP_0033004		
HP:0033003	biolink:PhenotypicFeature	Tracheal papilloma	A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the trachea.		hp.json		http://purl.obolibrary.org/obo/HP_0033003		
HP:0033006	biolink:PhenotypicFeature	Diffuse alveolar damage	Diffuse alveolar damage (DAD) describes a comon histologic injury pattern of the lung. The early stages are characterized by epithelial cell necrosis and sloughing, fibrous exsudate, edema, and hyaline membranes made of surfactant and proteins, filling the alveoli. This results in impaired gas exchange. In later stages, type II cells and myofibroblasts proliferate within the interstitium and airspaces. The corresponding clinical entity is acute respiratory distress syndrome (ARDS). DAD may result from pulmonary drug toxicity, occurs in immunosuppressed, severe viral infections, acute interstial pneumonitis and crack cocaine inhalation.		hp.json		http://purl.obolibrary.org/obo/HP_0033006		
HP:0033005	biolink:PhenotypicFeature	Plantar warts	Multiple verrucous lesions on the skin of the sole of the foot. These lesions are raised, have a thickened and rough surface, and may display prominent black dots (thrombosed capillaries). Palmar warts are caused by caused by human papillomavirus (HPV).		hp.json		http://purl.obolibrary.org/obo/HP_0033005		
HP:0033000	biolink:PhenotypicFeature	Subglottic laryngitis	Narrowing of the larynx, commonly occuring during viral respiratory tract infections, in particular in children, leads to symptoms such as hoarseness, a barking cough, stridor, and sometimes dyspnea and respiratory failure.		hp.json	Pseudocroup|Croup|Laryngitis|Spasmodic croup|Viral croup	http://purl.obolibrary.org/obo/HP_0033000		
HP:0033002	biolink:PhenotypicFeature	Bronchial papilloma	A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on a bronchus.		hp.json		http://purl.obolibrary.org/obo/HP_0033002		
HP:0033001	biolink:PhenotypicFeature	Laryngeal papilloma	A wart-like lesion (papilloma, i.e., benign epithelial tumors that are caused by infection with the human papilloma virus) located on the larynx.		hp.json	Laryngeal papillomatosis|Laryngeal papillomas	http://purl.obolibrary.org/obo/HP_0033001		
HP:0033008	biolink:PhenotypicFeature	Increased Z-disc width	Abnormally increased width of the Z-disk of the sarcomere, resulting from splitting or opening of the Z-disc (c.f., Figure 2 of PMID:28732005).		hp.json	Increased Z-disk width|Widened z-discs	http://purl.obolibrary.org/obo/HP_0033008		
HP:0033007	biolink:PhenotypicFeature	Architectural distortion of the lung	Architectural distortion is characterized by abnormal displacement of bronchi, vessels, fissures, or septa caused by diffuse or localized lung disease, particularly interstitial fibrosis. This is visible in lung biopsy and CT scans in a distorted appearance and is usually associated with pulmonary fibrosis and accompanied by volume loss.		hp.json		http://purl.obolibrary.org/obo/HP_0033007		
HP:0033009	biolink:PhenotypicFeature	Increased fecal coproporphyrin 1	Abnormally high concentration of coproporphyrin 3 in feces.		hp.json	Elevated stool coproporphyrin 1|Elevated faecal coproporphyrin 1|Elevated fecal coproporphyrin 1|High stool coproporphyrin 1|Increased faecal coproporphyrin 1|High fecal coproporphyrin 1|High faecal coproporphyrin 1	http://purl.obolibrary.org/obo/HP_0033009		
HP:0033015	biolink:PhenotypicFeature	Increased salivary cortisol level	Abnormally elevated concentration of cortisol in saliva.		hp.json		http://purl.obolibrary.org/obo/HP_0033015		
HP:0033014	biolink:PhenotypicFeature	Decreased salivary cortisol level	Abnormally reduced concentration of cortisol in saliva.		hp.json		http://purl.obolibrary.org/obo/HP_0033014		
HP:0033017	biolink:PhenotypicFeature	Transient decreased circulating IgD	A temporary reduction beneath the normal level of total immunoglobulin D (IgD) in the blood circulation.		hp.json	Transient decreaseed IgD in blood	http://purl.obolibrary.org/obo/HP_0033017		
HP:0033016	biolink:PhenotypicFeature	Chronic decreased circulating IgD	A lasting reduction beneath the normal level of total immunoglobulin D (IgD) in the blood.		hp.json	Chronic decreased IgM in blood	http://purl.obolibrary.org/obo/HP_0033016		
HP:0033011	biolink:PhenotypicFeature	Platystencephaly	Extreme width of the skull in the occipital region, with anterior narrowing and prognathism.		hp.json		http://purl.obolibrary.org/obo/HP_0033011		
HP:0033010	biolink:PhenotypicFeature	Increased fecal coproporphyrin 3	Abnormally high concentration of coproporphyrin 3 in feces		hp.json	High stool coproporphyrin 3|Increased faecal coproporphyrin 3|High fecal coproporphyrin 3|High faecal coproporphyrin 3|Elevated stool coproporphyrin 3|Elevated faecal coproporphyrin 3|Elevated fecal coproporphyrin 3	http://purl.obolibrary.org/obo/HP_0033010		
HP:0033013	biolink:PhenotypicFeature	Abnormal salivary cortisol level	Any deviation from the normal concentration of cortisol in saliva.		hp.json		http://purl.obolibrary.org/obo/HP_0033013		
HP:0033012	biolink:PhenotypicFeature	Abnormal salivary metabolite concentration	Any deviation from the normal concentration of a metabolite in saliva.		hp.json		http://purl.obolibrary.org/obo/HP_0033012		
HP:0033019	biolink:PhenotypicFeature	Male reproductive system neoplasm	A neoplasm that affects the male reproductive system.	NCIT:C3054	hp.json		http://purl.obolibrary.org/obo/HP_0033019		
HP:0033018	biolink:PhenotypicFeature	Chronic absent circulating IgD	A lasting absence of immunoglobulin D (IgD) in the blood, whereby at most trace quantities of IgD can be measured.		hp.json	Chronic (near) absent IgM in blood	http://purl.obolibrary.org/obo/HP_0033018		
HP:0033020	biolink:PhenotypicFeature	Female reproductive system neoplasm	A neoplasm that affects the female reproductive system.	NCIT:C3053	hp.json		http://purl.obolibrary.org/obo/HP_0033020		
HP:0045008	biolink:PhenotypicFeature	Abnormal shape of the radius		UMLS:C4022402	hp.json		http://purl.obolibrary.org/obo/HP_0045008		
HP:0045009	biolink:PhenotypicFeature	obsolete Abnormal morphology of the radius			hp.json		http://purl.obolibrary.org/obo/HP_0045009		
HP:0033026	biolink:PhenotypicFeature	White oral mucosal macule	A small circumscribed whitish change in the color of the oral mucosa that is neither elevated nor depressed.		hp.json		http://purl.obolibrary.org/obo/HP_0033026		
HP:0033025	biolink:PhenotypicFeature	Chronic absent circulating total IgG	A lasting absence of immunoglobulin G (IgG) in the blood, whereby at most trace quantities of IgG can be measured.		hp.json	Chronic (near) absent total IgG in blood	http://purl.obolibrary.org/obo/HP_0033025		
HP:0033028	biolink:PhenotypicFeature	Anti-U1 ribonucleoprotein antibody positivity	The presence autoantibodies in the serum that react to proteins (70 Kd, A, C) that are associated with U1 RNA and form U1snRNP.		hp.json	Anti-Scl-34 antibody positivity|Anti-RNP-antibodies|Anti-U1-RNP antibody positivity|Anti-U3 ribonucleoprotein antibody positivity	http://purl.obolibrary.org/obo/HP_0033028		
HP:0033027	biolink:PhenotypicFeature	Retinal peau d'orange	A pebbly orange appearance of the fundus that is said to resemble the skin of an orange.		hp.json		http://purl.obolibrary.org/obo/HP_0033027		
HP:0033022	biolink:PhenotypicFeature	Chronic decreased circulating IgE	A lasting reduction beneath the normal level of total immunoglobulin E (IgE) in the blood.		hp.json	Chronic decreased IgE in blood	http://purl.obolibrary.org/obo/HP_0033022		
HP:0033021	biolink:PhenotypicFeature	Transient decreased circulating IgE	A temporary reduction beneath the normal level of total immunoglobulin E (IgE) in the blood.		hp.json	Transient decreased IgE in blood	http://purl.obolibrary.org/obo/HP_0033021		
HP:0033024	biolink:PhenotypicFeature	Transient decreased circulating IgA	A temporary reduction beneath the normal level of total immunoglobulin A (IgA) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033024		
HP:0033023	biolink:PhenotypicFeature	Chronic absent circulating IgE	A lasting absence of immunoglobulin E (IgE) in the blood circulation, whereby at most trace quantities of IgE can be measured.		hp.json	Chronic (near) absent IgE in blood	http://purl.obolibrary.org/obo/HP_0033023		
OBO:MAXO_0000608	biolink:NamedThing	serum phosphate assessment	A quantitative measurement of the amount of phosphate present in a sample of serum.	NCIT:C61028	hp.json	serum phosphorus measurement|serum phosphate measurement	http://purl.obolibrary.org/obo/MAXO_0000608		
OBO:MAXO_0000609	biolink:NamedThing	serology testing	Testing blood serum for the presence of specifc antibody or antibodies to a specific antigen.  Often used when an infection is suspected.		hp.json	serology assay	http://purl.obolibrary.org/obo/MAXO_0000609		
OBO:MAXO_0000606	biolink:NamedThing	procalcitonin assessment	The determination of the amount of procalcitonin (human) present in the sample.	NCIT:C103430	hp.json	procalcitonin level testing|procalcitonin testing|procalcitonin level measurement|procalcitonin (human) test|procalcitonin (human) assessment	http://purl.obolibrary.org/obo/MAXO_0000606		
OBO:MAXO_0000607	biolink:NamedThing	D-dimer assessment	The determination of the amount of D-dimer (human) present in the sample.	NCIT:C82621	hp.json	D-dimer measurement|D-dimer (human) assessment|D-dimer (human) test|fibrin degradation fragment testing|D dimer level testing|fragment D-dimer testing	http://purl.obolibrary.org/obo/MAXO_0000607		
HP:0033029	biolink:PhenotypicFeature	obsolete Anti-Jo-1 antibody positivity			hp.json		http://purl.obolibrary.org/obo/HP_0033029		
GO:1905900	biolink:BiologicalProcess	negative regulation of smooth muscle tissue development	Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle tissue development.		hp.json	down regulation of smooth muscle tissue development|inhibition of smooth muscle tissue development|down-regulation of smooth muscle tissue development|downregulation of smooth muscle tissue development	http://purl.obolibrary.org/obo/GO_1905900		
GO:1905901	biolink:BiologicalProcess	positive regulation of smooth muscle tissue development	Any process that activates or increases the frequency, rate or extent of smooth muscle tissue development.		hp.json	activation of smooth muscle tissue development|upregulation of smooth muscle tissue development|up regulation of smooth muscle tissue development|up-regulation of smooth muscle tissue development	http://purl.obolibrary.org/obo/GO_1905901		
GO:1905902	biolink:BiologicalProcess	regulation of mesoderm formation	Any process that modulates the frequency, rate or extent of mesoderm formation.		hp.json		http://purl.obolibrary.org/obo/GO_1905902		
GO:1905903	biolink:BiologicalProcess	negative regulation of mesoderm formation	Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm formation.		hp.json	down regulation of mesoderm formation|inhibition of mesoderm formation|down-regulation of mesoderm formation|downregulation of mesoderm formation	http://purl.obolibrary.org/obo/GO_1905903		
HP:0045004	biolink:PhenotypicFeature	Abnormal ossification of the trapezoid bone		UMLS:C4022406	hp.json		http://purl.obolibrary.org/obo/HP_0045004		
HP:0045005	biolink:PhenotypicFeature	Neural tube defect	A neural tube defect arises when the neural tube, the embryonic precursor of the brain and spinal cord, fails to close during neurulation. The cranial region (anencephaly) or the low spine (open spina bifida; myelomeningocele) are most commonly affected although, in the severe NTD craniorachischisis, almost the entire neural tube remains open, from midbrain to low spine.	MSH:D009436|UMLS:C0027794|SNOMEDCT_US:253098009	hp.json	Abnormality of neural tube closure	http://purl.obolibrary.org/obo/HP_0045005		
GO:1905904	biolink:BiologicalProcess	positive regulation of mesoderm formation	Any process that activates or increases the frequency, rate or extent of mesoderm formation.		hp.json	upregulation of mesoderm formation|up regulation of mesoderm formation|activation of mesoderm formation|up-regulation of mesoderm formation	http://purl.obolibrary.org/obo/GO_1905904		
HP:0045006	biolink:PhenotypicFeature	Aplasia of lymphatic vessels	Aplasia (absence) of the lymphatic vessels.	UMLS:C4022404	hp.json	Absent lymphatic vessels	http://purl.obolibrary.org/obo/HP_0045006		
GO:1905905	biolink:BiologicalProcess	pharyngeal gland morphogenesis	The developmental process by which a pharyngeal gland is generated and organized.		hp.json	glandulae pharyngeae morphogenesis|pharynx gland morphogenesis	http://purl.obolibrary.org/obo/GO_1905905		
HP:0045007	biolink:PhenotypicFeature	Abnormal substantia nigra morphology	A structural anomaly of the substantia nigra, which is a midbrain dopaminergic nucleus which has a critical role in modulating motor movement and reward functions as part of the basal ganglia circuitry.	UMLS:C4022403	hp.json	Abnormality of the substantia nigra	http://purl.obolibrary.org/obo/HP_0045007		
OBO:MAXO_0000604	biolink:NamedThing	endocrine testing	A laboratory procedure that tests the function of an endocrine organ and measures the amount of a hormone present in a sample.	NCIT:C74971	hp.json		http://purl.obolibrary.org/obo/MAXO_0000604		
HP:0045001	biolink:PhenotypicFeature	Abnormal ossification of the trapezium		UMLS:C4022409	hp.json		http://purl.obolibrary.org/obo/HP_0045001		
OBO:MAXO_0000605	biolink:NamedThing	protein measurement	The determination of the amount of protein present in the sample.	NCIT:C64430	hp.json	protein assessment|protein test	http://purl.obolibrary.org/obo/MAXO_0000605		
HP:0045002	biolink:PhenotypicFeature	Absent ossification of the trapezium		UMLS:C4022408	hp.json		http://purl.obolibrary.org/obo/HP_0045002		
HP:0045003	biolink:PhenotypicFeature	Abnormal ossification of the scaphoid		UMLS:C4022407	hp.json		http://purl.obolibrary.org/obo/HP_0045003		
HP:0033031	biolink:PhenotypicFeature	Hyperpyrexia	An extreme elevation of core body temperature above normal defined as a rectal temperature of 41.1 degrees Celsius (106 degrees Fahrenheit).		hp.json		http://purl.obolibrary.org/obo/HP_0033031		
HP:0033030	biolink:PhenotypicFeature	Anti-glomerular basement membrane-antibody positivity	The presence of autoantibodies in the serum that react to the glomerular basement membrane.		hp.json	Anti-GBM-antibody positivity	http://purl.obolibrary.org/obo/HP_0033030		
HP:0033037	biolink:PhenotypicFeature	Migratory arthritis			hp.json	Migratory polyarthritis	http://purl.obolibrary.org/obo/HP_0033037		
HP:0033036	biolink:PhenotypicFeature	Decreased nasal nitric oxide	Reduced level of nasal nitric oxide (nNO). Current American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines for nNO measurements recommend air aspiration via a nasal probe while the subject exhales through the mouth against resistance in order to maintain velum closure.		hp.json	Low nasal nitric oxide level	http://purl.obolibrary.org/obo/HP_0033036		
HP:0033039	biolink:PhenotypicFeature	Increased circulating precipitin level	The presence of high titers of antigen-precipitating IgG in the serum.		hp.json	Increased level of antigen-precipitating IgG antibodies	http://purl.obolibrary.org/obo/HP_0033039		
HP:0033038	biolink:PhenotypicFeature	Anti-RNA-polymerase-III-autoantibody positivity	The presence of autoantibodies in the serum that react to RNA-polymerase III.		hp.json		http://purl.obolibrary.org/obo/HP_0033038		
HP:0033033	biolink:PhenotypicFeature	Anti-MDA5 antibody positivity	The presence of autoantibodies in the serum that react to Anti-MDA5 (Anti-melanoma differentiation-associated proteine 5).		hp.json	Increased level of anti-melanoma differentiation-associated protein 5 antibodies	http://purl.obolibrary.org/obo/HP_0033033		
HP:0033032	biolink:PhenotypicFeature	Triggered by an abusive adult	Applies to a sign or symptom that is induced by an abusive adult (usually a parent).		hp.json	Munchausen syndrome by proxy	http://purl.obolibrary.org/obo/HP_0033032		
HP:0033035	biolink:PhenotypicFeature	Abnormal Schwann cell morphology	Abormality of schwann cells, glial cells that ensheath axons of neurons in the peripheral nervous system and are necessary for their maintenance and function.		hp.json	Abnormal neurilemmocyte morphology|Abnormal neurilemmal cell morphology	http://purl.obolibrary.org/obo/HP_0033035		
OBO:uberon/core#transitively_anteriorly_connected_to	biolink:NamedThing	transitively anteriorly connected to	.		hp.json		http://purl.obolibrary.org/obo/uberon/core#transitively_anteriorly_connected_to		
HP:0033034	biolink:PhenotypicFeature	Anti-citrullinated protein antibody positivity	The presence autoantibodies in the serum that react do different citrullinated antigens, including filaggrin, fibrinogen, vimentin and collagen.		hp.json		http://purl.obolibrary.org/obo/HP_0033034		
HP:0045010	biolink:PhenotypicFeature	Abnormality of peripheral nerves		UMLS:C4022400	hp.json		http://purl.obolibrary.org/obo/HP_0045010		
HP:0045016	biolink:PhenotypicFeature	obsolete Elevated serum long-chain fatty acids			hp.json	Increased serum long-chain fatty acids	http://purl.obolibrary.org/obo/HP_0045016		
HP:0045017	biolink:PhenotypicFeature	Congenital malformation of the left heart	Defect or defects of the morphogenesis of the left heart identifiable at birth.	UMLS:C4022397	hp.json		http://purl.obolibrary.org/obo/HP_0045017		
HP:0045018	biolink:PhenotypicFeature	Partial duplication of eyebrows		UMLS:C4022396	hp.json	Partial duplication of eyebrows|Partial double eyebrow	http://purl.obolibrary.org/obo/HP_0045018		
HP:0045011	biolink:PhenotypicFeature	Decreased urine bicarbonate concentration	Abnormally decreased concentration of hydrogencarbonate in the urine.	UMLS:C4022399	hp.json	Decreased urine HCO3 concentration	http://purl.obolibrary.org/obo/HP_0045011		
HP:0045012	biolink:PhenotypicFeature	Decreased urinary catecholamine concentration		UMLS:C4022398	hp.json		http://purl.obolibrary.org/obo/HP_0045012		
HP:0045013	biolink:PhenotypicFeature	obsolete Decreased urinary glucose concentration			hp.json		http://purl.obolibrary.org/obo/HP_0045013		
HP:0045014	biolink:PhenotypicFeature	Hypolipidemia		UMLS:C0342892|SNOMEDCT_US:238090007	hp.json		http://purl.obolibrary.org/obo/HP_0045014		
HP:0011890	biolink:PhenotypicFeature	Prolonged bleeding following procedure	Prolonged or protracted bleeding following an invasive procedure or intervention.	UMLS:C4023142	hp.json	Prolonged bleeding following procedure	http://purl.obolibrary.org/obo/HP_0011890		
HP:0011891	biolink:PhenotypicFeature	Post-partum hemorrhage	Significant maternal haemorrhage/blood loss following deilvery of a child.	MSH:D006473|SNOMEDCT_US:47821001|UMLS:C0032797	hp.json	Bleeding post-delivery|Post-partum haemorrhage	http://purl.obolibrary.org/obo/HP_0011891		
HP:0011892	biolink:PhenotypicFeature	Low levels of vitamin K	A reduced concentration of vitamin K.	SNOMEDCT_US:52675005|MSH:D014813|UMLS:C0042880	hp.json		http://purl.obolibrary.org/obo/HP_0011892		
HP:0008240	biolink:PhenotypicFeature	Secondary growth hormone deficiency		UMLS:C4024716	hp.json		http://purl.obolibrary.org/obo/HP_0008240		
HP:0011893	biolink:PhenotypicFeature	Abnormal leukocyte count	Number of leukocytes per volume of blood beyond normal limits.	UMLS:C0580531|SNOMEDCT_US:165509000	hp.json	Abnormal white blood cell count	http://purl.obolibrary.org/obo/HP_0011893		
HP:0011894	biolink:PhenotypicFeature	Impaired thromboxane A2 agonist-induced platelet aggregation	Abnormal response to thromboxane as manifested by reduced or lacking aggregation of platelets upon addition of thromboxane A2 receptor agonists.	UMLS:C4023141	hp.json		http://purl.obolibrary.org/obo/HP_0011894		
HP:0011895	biolink:PhenotypicFeature	Anemia due to reduced life span of red cells	A type of anemia related to a reduction in the average life span of red blood cells in the peripheral circulation, which is normally around 120 days.	UMLS:C4021112	hp.json	Anaemia due to reduced life span of red cells	http://purl.obolibrary.org/obo/HP_0011895		
HP:0011896	biolink:PhenotypicFeature	Subconjunctival hemorrhage	Bleeding beneath the mucous membrane that lines the inner surface of the eyelid.	UMLS:C0038534|SNOMEDCT_US:78768009	hp.json	Subconjunctival haemorrhage	http://purl.obolibrary.org/obo/HP_0011896		
HP:0011897	biolink:PhenotypicFeature	Neutrophilia	Increased number of neutrophils circulating in blood.	UMLS:C4023140	hp.json	Increased blood neutrophil counts	http://purl.obolibrary.org/obo/HP_0011897		
HP:0033202	biolink:PhenotypicFeature	Brachioradialis hyporeflexia	Reduced intensity of the brachioradialis tendon reflex.		hp.json		http://purl.obolibrary.org/obo/HP_0033202		
HP:0033201	biolink:PhenotypicFeature	Biceps hyporeflexia	Reduced intensity of the biceps tendon reflex.		hp.json	Hyporeflexia of biceps	http://purl.obolibrary.org/obo/HP_0033201		
HP:0033204	biolink:PhenotypicFeature	Triceps hyperreflexia	Increased intensity of the triceps reflex.		hp.json		http://purl.obolibrary.org/obo/HP_0033204		
HP:0033203	biolink:PhenotypicFeature	Brachioradialis hyperreflexia	Increased intensity of the brachioradialis reflex.		hp.json		http://purl.obolibrary.org/obo/HP_0033203		
CHEBI:26421	biolink:ChemicalSubstance	pyridines	Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives.		hp.json		http://purl.obolibrary.org/obo/CHEBI_26421		3_STAR
HP:0033200	biolink:PhenotypicFeature	Triceps hyporeflexia	Reduced intensity of the triceps tendon reflex.		hp.json	Hyporeflexia of triceps	http://purl.obolibrary.org/obo/HP_0033200		
HP:0033209	biolink:PhenotypicFeature	Acinar dysplasia	Arrest of lung development in the pseudoglandular stage (weeks 8 to 16 of human gestation) resulting in small sized lungs, predominantly composed of bronchial and bronchiolar structures embedded in abundant loose mesenchyme that is poorly vascularized. Acinar structures are essentially absent, with no significant formation of saccules and no alveoli.		hp.json		http://purl.obolibrary.org/obo/HP_0033209		
HP:0033206	biolink:PhenotypicFeature	Hyperactive Achilles reflex	Increased intensity of the Achilles reflex.		hp.json	Hyperactive ankle reflex|Hyperactive ankle jerk reflex	http://purl.obolibrary.org/obo/HP_0033206		
HP:0008239	biolink:PhenotypicFeature	Adrenal medullary hypoplasia	Developmental hypoplasia of the adrenal medulla.	UMLS:C4024717	hp.json	Small adrenal medulla	http://purl.obolibrary.org/obo/HP_0008239		
HP:0033205	biolink:PhenotypicFeature	Biceps hyperreflexia	Increased intensity of the biceps reflex.		hp.json		http://purl.obolibrary.org/obo/HP_0033205		
HP:0033208	biolink:PhenotypicFeature	Alveolar capillary dysplasia	A developmental defect of the alveolar airspace during cananicular lung development characterized by a decreased number of pulmonary capillaries located away from the alveolar epithelium, thickened alveolar septae, media hypertrophy of small pulmonary arteries and muscularization of distal arterioles, and in some cases lymphangiectasis.		hp.json		http://purl.obolibrary.org/obo/HP_0033208		
HP:0033207	biolink:PhenotypicFeature	Increased proportion autoreactive unresponsive CD21-/low B cells	Increased proportion relative to B-lymphocytes of a subset of B lymphocytes characterized by dim/low levels of CD21, i.e., CD21-/low, in flow cytometry, and additionally enriched in autoreactive clones as determined for instance by clonse showing rheumatoid factor (anti-IgG) reactivity and antibodies recognizing cytoplasmic and to a lesser extent nuclear structures.		hp.json		http://purl.obolibrary.org/obo/HP_0033207		
HP:0011898	biolink:PhenotypicFeature	Abnormality of circulating fibrinogen	An abnormality of the level of activity of circulating fibrinogen.	UMLS:C4023139	hp.json		http://purl.obolibrary.org/obo/HP_0011898		
HP:0011899	biolink:PhenotypicFeature	Hyperfibrinogenemia	Increased concentration of fibrinogen in the blood.	SNOMEDCT_US:439000005|UMLS:C0919890	hp.json		http://purl.obolibrary.org/obo/HP_0011899		
HP:0008237	biolink:PhenotypicFeature	Hypothalamic hypothyroidism	A type of hypothyroidism that results from a defect in thyrotropin-releasing hormone activity.	UMLS:C0220998|SNOMEDCT_US:37429009	hp.json	Tertiary hypothyroidism	http://purl.obolibrary.org/obo/HP_0008237		
HP:0008236	biolink:PhenotypicFeature	Isosexual precocious puberty		UMLS:C0271528|SNOMEDCT_US:4294006	hp.json		http://purl.obolibrary.org/obo/HP_0008236		
HP:0008231	biolink:PhenotypicFeature	Macronodular adrenal hyperplasia		SNOMEDCT_US:237778003|UMLS:C0342495	hp.json		http://purl.obolibrary.org/obo/HP_0008231		
HP:0008230	biolink:PhenotypicFeature	obsolete Decreased testosterone in males			hp.json		http://purl.obolibrary.org/obo/HP_0008230		
HP:0008233	biolink:PhenotypicFeature	Decreased circulating progesterone	An reduced concentration of progesterone in the blood.	UMLS:C1858995	hp.json	Decreased serum progesterone	http://purl.obolibrary.org/obo/HP_0008233		
HP:0008232	biolink:PhenotypicFeature	Elevated circulating follicle stimulating hormone level	An elevated concentration of follicle-stimulating hormone in the blood.	UMLS:C4021550	hp.json	Elevated follicle-stimulating hormone|Elevated plasma follicle stimulating hormone|Elevated follicle stimulating hormone|Increased circulating follicle stimulating hormone level|Elevated FSH level	http://purl.obolibrary.org/obo/HP_0008232		
HP:0011880	biolink:PhenotypicFeature	Acute disseminated intravascular coagulation	An acute form of disseminated intravascular coagulation. Acute DIC can occur following sudden exposure of blood to procoagulants, with the compensatory hemostatic mechanisms becoming overwhelmed.	UMLS:C4023149	hp.json		http://purl.obolibrary.org/obo/HP_0011880		
HP:0008251	biolink:PhenotypicFeature	Congenital goiter	An enlargement of the thyroid gland with congenital onset.	SNOMEDCT_US:276565004|UMLS:C0349476	hp.json	Congenital goitre	http://purl.obolibrary.org/obo/HP_0008251		
HP:0011881	biolink:PhenotypicFeature	Decreased platelet glycoprotein VI	Decreased cell membrane concentration of glycoprotein VI.	UMLS:C4023148	hp.json		http://purl.obolibrary.org/obo/HP_0011881		
HP:0008250	biolink:PhenotypicFeature	Infantile hypercalcemia		SNOMEDCT_US:276645004|MSH:C562999|UMLS:C0475732	hp.json		http://purl.obolibrary.org/obo/HP_0008250		
HP:0011882	biolink:PhenotypicFeature	Decreased platelet P2Y12 receptor	Decreased cell membrane concentration of P2Y12 receptor.	UMLS:C4023147	hp.json		http://purl.obolibrary.org/obo/HP_0011882		
HP:0011883	biolink:PhenotypicFeature	Abnormal platelet granules	An anomaly of alpha or dense granules or platelet lysosomes.	UMLS:C4023146	hp.json		http://purl.obolibrary.org/obo/HP_0011883		
HP:0011884	biolink:PhenotypicFeature	Abnormal umbilical stump bleeding	Abnormal bleeding of the umbilical stump following separation of the cord at approximately 7-10 days after birth.	UMLS:C4023145	hp.json		http://purl.obolibrary.org/obo/HP_0011884		
HP:0011885	biolink:PhenotypicFeature	Hemorrhage of the eye	Bleeding from vessels of the various tissues of the eye.	UMLS:C0015402|MSH:D005130|SNOMEDCT_US:417244000|SNOMEDCT_US:93478000	hp.json	Haemorrhage of the eye|Bleeding from the eye	http://purl.obolibrary.org/obo/HP_0011885		
HP:0011886	biolink:PhenotypicFeature	Hyphema	Bleeding in the anterior chamber of the eye.	UMLS:C0020581|MSH:D006988|SNOMEDCT_US:75229002	hp.json		http://purl.obolibrary.org/obo/HP_0011886		
HP:0033213	biolink:PhenotypicFeature	Elevated urine suberic acid level	An increased in the level of suberic acid in the urine above the normal range. Suberic acid is an alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane.		hp.json	Elevated urine octanedioic acid level	http://purl.obolibrary.org/obo/HP_0033213		
HP:0033212	biolink:PhenotypicFeature	Abnormal total iron binding capacity	Any deviation from the normal total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added.		hp.json		http://purl.obolibrary.org/obo/HP_0033212		
GO:0097084	biolink:BiologicalProcess	vascular associated smooth muscle cell development	The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.		hp.json	vascular smooth muscle cell development	http://purl.obolibrary.org/obo/GO_0097084		
HP:0033215	biolink:PhenotypicFeature	Obliterative abnormality of the renal glomerulus			hp.json		http://purl.obolibrary.org/obo/HP_0033215		
CHEBI:26432	biolink:ChemicalSubstance	pyrimidine nucleobase	A nucleobase whose skeleton is derived from pyrimidine.		hp.json	pyrimidine nucleobase|a pyrimidine nucleobase|pyrimidine nucleobases|pyrimidine bases	http://purl.obolibrary.org/obo/CHEBI_26432		3_STAR
HP:0033214	biolink:PhenotypicFeature	Recurrent viral pneumonia	Increased susceptibility to viral pneumonia, as manifested by recurrent episodes of viral pneumonias.		hp.json		http://purl.obolibrary.org/obo/HP_0033214		
HP:0033211	biolink:PhenotypicFeature	Decreased total iron binding capacity	A reduction in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity.		hp.json		http://purl.obolibrary.org/obo/HP_0033211		
HP:0033210	biolink:PhenotypicFeature	Congenital alveolar dysplasia	Arrest of lung development in the cananicular stage (weeks 18 to 26 of human gestation) resulting in simplified acinar spaces, frequently with abundant intervening mesenchyme and no alveoli. In later arrest growth stages early saccular formations may be seen. May resemble the lobular maldevelopment often seen in alveolar capillary dysplasia/misaligment of the pulmonary veins without vein misalignment or marked hypertensive changes of the pulmonary arteries.		hp.json		http://purl.obolibrary.org/obo/HP_0033210		
HP:0033217	biolink:PhenotypicFeature	Perihilar glomerular hyalinosis	Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the vascular pole/perihilum.		hp.json		http://purl.obolibrary.org/obo/HP_0033217		
HP:0008249	biolink:PhenotypicFeature	Thyroid hyperplasia	Hyperplasia of the thyroid gland.	UMLS:C1112776	hp.json	Large thyroid	http://purl.obolibrary.org/obo/HP_0008249		
HP:0033216	biolink:PhenotypicFeature	Glomerular hyalinosis	Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus. Distribution can include vascular pole, perihilar, tip or neither tip, perihilar or vascular.		hp.json		http://purl.obolibrary.org/obo/HP_0033216		
HP:0033219	biolink:PhenotypicFeature	Glomerular hyalinosis away from the vascular and tubular poles	Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at neither tip nor perihilar/vascular poles. Both the vascular and the tubular pole are present in the glomerular cross section.		hp.json		http://purl.obolibrary.org/obo/HP_0033219		
HP:0033218	biolink:PhenotypicFeature	Glomerular hyalinosis at the tubular pole	Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material in the glomerulus at the tip/tubular pole.		hp.json		http://purl.obolibrary.org/obo/HP_0033218		
HP:0011887	biolink:PhenotypicFeature	Choroid hemorrhage	Hemorrhage from the vessels of the choroid.	SNOMEDCT_US:122003|UMLS:C0008522|MSH:D002832	hp.json	Choroidal hemorrhage|Choroid haemorrhage|Choroidal haemorrhage	http://purl.obolibrary.org/obo/HP_0011887		
HP:0011888	biolink:PhenotypicFeature	Bleeding requiring red cell transfusion	Bleeding sufficiently severe as to require red cell transfusion (WHO Grade 3 or 4).	UMLS:C4023144	hp.json	Bleeding requiring red cell transfusion	http://purl.obolibrary.org/obo/HP_0011888		
HP:0008245	biolink:PhenotypicFeature	Pituitary hypothyroidism	A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion.	UMLS:C3665349|SNOMEDCT_US:82598004	hp.json	TSH deficient hypothyroidism|Low thyroid gland function due to abnormal pituitary gland|Thyroid stimulating hormone deficiency|Thyrotropin deficiency|Secondary hypothyroidism	http://purl.obolibrary.org/obo/HP_0008245		
HP:0011889	biolink:PhenotypicFeature	Bleeding with minor or no trauma	Significant bleeding or hemorrhage without significant precipitating factor.	UMLS:C4023143	hp.json	Easy bleeding|Bleeding with minor or no trauma	http://purl.obolibrary.org/obo/HP_0011889		
HP:0008247	biolink:PhenotypicFeature	Euthyroid hyperthyroxinemia	An abnormality of thyroid physiology (HP:0002926) characterized by increased levels of thyroxine without evidence of clinical thyroid disease.	UMLS:C4021549	hp.json	Asymptomatic hyperthyroxinemia	http://purl.obolibrary.org/obo/HP_0008247		
HP:0008242	biolink:PhenotypicFeature	Pseudohypoaldosteronism	A state of renal tubular unresponsiveness or resistance to the action of aldosterone.	UMLS:C0033805|MSH:D011546|SNOMEDCT_US:77098009	hp.json		http://purl.obolibrary.org/obo/HP_0008242		
HP:0008244	biolink:PhenotypicFeature	Congenital adrenal hypoplasia	A type of adrenal hypoplasia with congenital onset.	UMLS:C0220766|SNOMEDCT_US:93235007	hp.json	Congenital adrenal gland hypoplasia	http://purl.obolibrary.org/obo/HP_0008244		
HP:0011870	biolink:PhenotypicFeature	Impaired arachidonic acid-induced platelet aggregation	Abnormal response to arachidonic acid as manifested by reduced or lacking aggregation of platelets upon addition of arachidonic acid.	UMLS:C4023155	hp.json		http://purl.obolibrary.org/obo/HP_0011870		
HP:0011871	biolink:PhenotypicFeature	Impaired ristocetin-induced platelet aggregation	Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin.	UMLS:C4023154	hp.json		http://purl.obolibrary.org/obo/HP_0011871		
HP:0011872	biolink:PhenotypicFeature	Impaired thrombin-induced platelet aggregation	Abnormal response to thrombin or thrombin mimetics as manifested by reduced or lacking aggregation of platelets upon addition of thrombin (or thrombin mimetics).	UMLS:C4023153	hp.json		http://purl.obolibrary.org/obo/HP_0011872		
CHEBI:26401	biolink:ChemicalSubstance	purines	A class of imidazopyrimidines that consists of purine and its substituted derivatives.		hp.json		http://purl.obolibrary.org/obo/CHEBI_26401		3_STAR
HP:0011873	biolink:PhenotypicFeature	Abnormal platelet count	Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood.	UMLS:C0580317|SNOMEDCT_US:165558001	hp.json		http://purl.obolibrary.org/obo/HP_0011873		
HP:0011874	biolink:PhenotypicFeature	Heparin-induced thrombocytopenia	Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin.	UMLS:C0272285|SNOMEDCT_US:73397007	hp.json		http://purl.obolibrary.org/obo/HP_0011874		
HP:0011875	biolink:PhenotypicFeature	Abnormal platelet morphology	An anomaly in platelet form, ultrastructure, or intracellular organelles.	UMLS:C0855742	hp.json	Abnormal shape of platelets	http://purl.obolibrary.org/obo/HP_0011875		
HP:0033224	biolink:PhenotypicFeature	Glomerular parietal epithelial cell hyperplasia	Increased number of parietal epithelial cells lining Bowman's capsule. Hyperplasia leads to the cells being present in 2 or more layers, often with crowding and multilayering.		hp.json	Hyperplasia of the glomerular parietal epithelial cell	http://purl.obolibrary.org/obo/HP_0033224		
HP:0033223	biolink:PhenotypicFeature	Abnormal glomerular parietal epithelial cell morphology	Any structural abnormality of the parietal epithelial cells that line the inside of Bowman's capsule and form an inconspicuous sheet of flat epithelial cells in continuity with the proximal tubular epithelial cells at the urinary pole and with the podocytes at the vascular pole.		hp.json		http://purl.obolibrary.org/obo/HP_0033223		
UBERON:0011693	biolink:AnatomicalEntity	extraembryonic portion of umbilical artery		VHOG:0001157	hp.json	extraembryonic umbilical artery	http://purl.obolibrary.org/obo/UBERON_0011693		
HP:0033226	biolink:PhenotypicFeature	Bowman capsular hyaline drops	An insudative accumulation of amorphous, eosinophilic, periodic acid-Schiff (PAS)-positive, silver-negative material protruding from Bowman's capsule into the urinary space. Although not always evident by light microscopy, this material is located between Bowman's capsule and the parietal epithelial cells, in some cases associated with newly formed matrix material.		hp.json	Capsular hyaline drops within Bowman's capsule	http://purl.obolibrary.org/obo/HP_0033226		
HP:0033225	biolink:PhenotypicFeature	Glomerular parietal epithelial cell hypertrophy	An abnormality of the glomerular parietal epithelial cells characterized by (1) Increased parietal epithelial cell size, with or without cytoplasmic protein droplets; or (2) enlarged nuclei with prominent nucleoli. Both features can be present		hp.json	Hypertrophy of the glomerular parietal epithelial cell	http://purl.obolibrary.org/obo/HP_0033225		
HP:0033220	biolink:PhenotypicFeature	2-ethylhydracylic aciduria	An increased concentration of 2-ethylhydracylic acid in the urine.		hp.json	Elevated urinary 2-ethylhydracylic acid|Elevated urinary 2-methylbutyrylglycine	http://purl.obolibrary.org/obo/HP_0033220		
UBERON:0011697	biolink:AnatomicalEntity	right extraembryonic umbilical artery		EHDAA2:0001721	hp.json	extraembryonic umbilical artery right	http://purl.obolibrary.org/obo/UBERON_0011697		
UBERON:0011696	biolink:AnatomicalEntity	left extraembryonic umbilical artery		EHDAA2:0000937	hp.json	extraembryonic umbilical artery left	http://purl.obolibrary.org/obo/UBERON_0011696		
HP:0033222	biolink:PhenotypicFeature	Decreased CD4:CD8 ratio	An abnormal reduction of the relative proportion of CD4+ to CD8+ T cells.		hp.json	Inverted CD4:CD8 ratio|Inverted CD4/CD8 ratio	http://purl.obolibrary.org/obo/HP_0033222		
UBERON:0011695	biolink:AnatomicalEntity	embryonic cardiovascular system	A cardiovascular system that is part of a conceptus.	FMA:305965|EHDAA2:0000216|NCIT:C34148	hp.json	conceptus cardiovascular system|embryonic circulatory system|fetal circulatory system	http://purl.obolibrary.org/obo/UBERON_0011695		
HP:0033221	biolink:PhenotypicFeature	Increased CD4:CD8 ratio	An abnormal elevation of the relative proportion of CD4+ to CD8+ T cells.		hp.json		http://purl.obolibrary.org/obo/HP_0033221		
HP:0033228	biolink:PhenotypicFeature	Triceps areflexia	Inability to elicit triceps tendon reflex.		hp.json	Areflexia of triceps	http://purl.obolibrary.org/obo/HP_0033228		
HP:0008216	biolink:PhenotypicFeature	Adrenal gland dysgenesis	Abnormal development of the adrenal gland.	UMLS:C1856017	hp.json	Dysplastic adrenal glands|Adrenal gland dysplasia	http://purl.obolibrary.org/obo/HP_0008216		
HP:0033227	biolink:PhenotypicFeature	Glomerular synechial adhesion	An area of basement membrane continuity between the glomerular tuft and Bowman's capsule, without intervening crescent and not adjacent to an area of segmental sclerosis.		hp.json		http://purl.obolibrary.org/obo/HP_0033227		
HP:0033229	biolink:PhenotypicFeature	Brachioradialis areflexia	Inability to elicit brachioradialis tendon reflex.		hp.json	Areflexia of brachioradialis	http://purl.obolibrary.org/obo/HP_0033229		
HP:0011876	biolink:PhenotypicFeature	Abnormal platelet volume	Anomalous size of platelets. Most normal sized platelets are 1.5 to 3 micrometers in diameter. Large platelets are 4 to 7 micrometers. Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers.	UMLS:C4023152	hp.json		http://purl.obolibrary.org/obo/HP_0011876		
HP:0008213	biolink:PhenotypicFeature	Gonadotropin deficiency	A reduced ability to secrete gonadotropins, which are protein hormones secreted by gonadotrope cells of the anterior pituitary gland, including the hormones follitropin (FSH) and luteinizing hormone (LH).	UMLS:C0271623|SNOMEDCT_US:33927004|MSH:D007006	hp.json	Pituitary gonadotropin deficiency	http://purl.obolibrary.org/obo/HP_0008213		
HP:0011877	biolink:PhenotypicFeature	Increased mean platelet volume	Average platelet volume above the upper limit of the normal reference interval.	UMLS:C1096367	hp.json	Large platelets	http://purl.obolibrary.org/obo/HP_0011877		
HP:0011878	biolink:PhenotypicFeature	Abnormal platelet membrane protein expression	Presence of reduced amount of a membrane protein on the cell membrane of platelets. This feature is typically measured by flow cytometry.	UMLS:C4023151	hp.json		http://purl.obolibrary.org/obo/HP_0011878		
HP:0008214	biolink:PhenotypicFeature	Decreased serum estradiol	A reduction below normal concentration of estradiol in the circulation.	SNOMEDCT_US:166449002|UMLS:C0241011	hp.json	Decreased serum estradiol	http://purl.obolibrary.org/obo/HP_0008214		
HP:0011879	biolink:PhenotypicFeature	Decreased platelet glycoprotein Ib-IX-V	Decreased cell membrane concentration of the glycoprotein complex Ib-IX-V.	UMLS:C4023150	hp.json		http://purl.obolibrary.org/obo/HP_0011879		
HP:0008211	biolink:PhenotypicFeature	Parathyroid agenesis	Aplasia of the parathyroid gland.	MSH:C563238|SNOMEDCT_US:73291005|UMLS:C1321907	hp.json	Parathyroid aplasia|Parathyroid absence	http://purl.obolibrary.org/obo/HP_0008211		
HP:0011860	biolink:PhenotypicFeature	Metaphyseal dappling	The presence of spots or rounded patches of abnormally increased density of metaphyseal bone.	UMLS:C4020907	hp.json	Dappled metaphyseal sclerosis	http://purl.obolibrary.org/obo/HP_0011860		
HP:0011861	biolink:PhenotypicFeature	Bilateral trilobed lung	Both lungs have three lobes. Normally, the left lung has two lobes, whereas the right lung has three lobes.	SNOMEDCT_US:448648001|UMLS:C3164377	hp.json	Bilateral trilobed lungs	http://purl.obolibrary.org/obo/HP_0011861		
HP:0011862	biolink:PhenotypicFeature	Abnormal bone collagen fibril morphology	Any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity.	UMLS:C4023158	hp.json		http://purl.obolibrary.org/obo/HP_0011862		
HP:0011863	biolink:PhenotypicFeature	Abnormal sternal ossification	Any anomaly in the formation of the bony substance of the sternum.	UMLS:C1860243	hp.json	Sternal ossification centre abnormalities|Sternal ossification center abnormalities|Abnormal maturation of breastbone	http://purl.obolibrary.org/obo/HP_0011863		
HP:0011864	biolink:PhenotypicFeature	Elevated plasma pyrophosphate	An abnormally increased diphosphate(4-) concentration in the blood. Diphosphate(4-), as ester with two phosphate groups, is also known as pyrophosphate.	UMLS:C4023157	hp.json		http://purl.obolibrary.org/obo/HP_0011864		
GO:0097060	biolink:CellularComponent	synaptic membrane	A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.		hp.json		http://purl.obolibrary.org/obo/GO_0097060		goslim_synapse
HP:0033235	biolink:PhenotypicFeature	Difficulty descending stairs	Reduced ability to desscend stairs.		hp.json	Difficulty walking down stairs	http://purl.obolibrary.org/obo/HP_0033235		
HP:0033234	biolink:PhenotypicFeature	Mesangial hyaline deposition	Extracellular mesangial accumulation of moderately electron-dense, generally homogenous, amorphous-appearing extracellular material.		hp.json		http://purl.obolibrary.org/obo/HP_0033234		
HP:0033237	biolink:PhenotypicFeature	Visceral epithelial cell detachment	Detachment of visceral epithelial cells (podocytes) from underlying glomerular basement membrane with intervening new loose basement membrane material (pale on Hematoxylin and eosin, periodic acid-Shiff, trichrome, or silver stain) forming a so-called 'halo'.		hp.json	Detachment of visceral epithelial cells|Podocyte detachment	http://purl.obolibrary.org/obo/HP_0033237		
HP:0033236	biolink:PhenotypicFeature	Cognitive fatigue	A failure to sustain attention that requires self-motivation to optimize performance.		hp.json	Central fatigue	http://purl.obolibrary.org/obo/HP_0033236		
HP:0033231	biolink:PhenotypicFeature	Abnormal glomerular mesangial cellularity	Abnormal number of its constituent cells of the mesangium of the glomerulus of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033231		
HP:0033230	biolink:PhenotypicFeature	Biceps areflexia	Inability to elicit biceps tendon reflex.		hp.json	Areflexia of biceps	http://purl.obolibrary.org/obo/HP_0033230		
HP:0033233	biolink:PhenotypicFeature	Paramesangial deposits	Mesangial immune deposit located adjacent to the paramesangial glomerular basement membrane.		hp.json		http://purl.obolibrary.org/obo/HP_0033233		
HP:0033232	biolink:PhenotypicFeature	Abnormal glomerular mesangial matrix morphology	Any structural anomaly of the glomerular matrix. Mesangial cells generate and embed in their own extracellular matrix. The mesangial matrix is different in composition from the glomerular basement membrane. Its constituents are type IV collagen (but only the alpha1 and alpha2 chains); type V collagen; laminin A, B1, and B2; and considerable amounts of fibronectin, heparan sulfate and chondroitin sulfate proteoglycans, entactin, and nidogen. Furthermore, small amounts of the proteoglycans decorin and biglycan are found in the mesangial matrix.		hp.json		http://purl.obolibrary.org/obo/HP_0033232		
UBERON:0011679	biolink:AnatomicalEntity	proximal tarsal bone	A tarsal bone that connected_to a hindlimb zeugopod skeleton.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011679		
UBERON:0011678	biolink:AnatomicalEntity	hindlimb intermedium bone	A proximal tarsal bone that articulates with the fibula.	AAO:0000923	hp.json	hidlimb intermedium|pedal intermedium|intermedium (hind)|intermedium|intermedium of pes	http://purl.obolibrary.org/obo/UBERON_0011678		
UBERON:0011677	biolink:AnatomicalEntity	trunk vertebra	A vertebra in the trunk region. For tetrapods, includes lumbar and thoracic vertebrae. Excludes caudal/coccygeal vertebra, which are located posteriorly. In tetrapods this includes thoracic, lumbar and sacral vertebrae, and excludes the cervical vertebrae, which are located anteriorly.		hp.json	presacral vertebra|thoracolumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0011677		pheno_slim
HP:0033239	biolink:PhenotypicFeature	Visceral epithelial cell capping	Layer of hypertrophied visceral epithelial cells overlying a sclerosed segment of the tuft of the glomerulus.		hp.json	Podocyte cap	http://purl.obolibrary.org/obo/HP_0033239		
HP:0008227	biolink:PhenotypicFeature	Pituitary resistance to thyroid hormone	A condition in which the pituitary gland is partially resistant to thyroid hormone, so that it continues to secrete thyroid-stimulating hormone (TSH) until the blood level of thyroid hormone rises higher than normal.	SNOMEDCT_US:360348000|SNOMEDCT_US:360353005|UMLS:C0342198	hp.json		http://purl.obolibrary.org/obo/HP_0008227		
HP:0033238	biolink:PhenotypicFeature	Podocyte microvillous transformation	Cytoplasmic projections into the urinary space from the luminal side of the podocyte.		hp.json		http://purl.obolibrary.org/obo/HP_0033238		
HP:0008229	biolink:PhenotypicFeature	Thyroid lymphangiectasia	The presence of lymphangiectasis of the thyroid gland.	UMLS:C1856129	hp.json	Thyroid lymphangiectasis	http://purl.obolibrary.org/obo/HP_0008229		
HP:0008223	biolink:PhenotypicFeature	Compensated hypothyroidism	Condition associated with a raised serum concentration of thyroid stimulating hormone (TSH) but a normal serum free thyroxine (FT4).	SNOMEDCT_US:237523006|UMLS:C0342162	hp.json	Mild hypothyroidism|Subclinical hypothyroidism	http://purl.obolibrary.org/obo/HP_0008223		
HP:0011867	biolink:PhenotypicFeature	Abnormal iliac wing morphology	An anomaly of the ilium ala. This is the large expanded portion of the ilum which bounds the greater pelvis laterally.	UMLS:C4023156	hp.json	Abnormality of the wing of the ilium	http://purl.obolibrary.org/obo/HP_0011867		
HP:0008226	biolink:PhenotypicFeature	Androgen insufficiency	Insufficient amount of androgenic activity.	UMLS:C0342527|SNOMEDCT_US:38825009	hp.json	Hypoandrogenism	http://purl.obolibrary.org/obo/HP_0008226		
HP:0011868	biolink:PhenotypicFeature	Sciatica	Pain in the lower back and hip radiating in the distribution of the sciatic nerve.	MSH:D012585|SNOMEDCT_US:23056005|UMLS:C0036396	hp.json		http://purl.obolibrary.org/obo/HP_0011868		
HP:0008225	biolink:PhenotypicFeature	Thyroid follicular hyperplasia		UMLS:C1969546	hp.json		http://purl.obolibrary.org/obo/HP_0008225		
OBI:0100026	biolink:NamedThing	organism			hp.json		http://purl.obolibrary.org/obo/OBI_0100026		
HP:0011869	biolink:PhenotypicFeature	Abnormal platelet function	Any anomaly in the function of thrombocytes.	UMLS:C0855740	hp.json		http://purl.obolibrary.org/obo/HP_0011869		
HP:0008222	biolink:PhenotypicFeature	Female infertility		SNOMEDCT_US:6738008|MSH:D007247|UMLS:C0021361	hp.json	Female infertility	http://purl.obolibrary.org/obo/HP_0008222		
HP:0008221	biolink:PhenotypicFeature	Adrenal hyperplasia	Enlargement of the adrenal gland.	UMLS:C1621895|SNOMEDCT_US:419920004	hp.json	Enlarged adrenal glands	http://purl.obolibrary.org/obo/HP_0008221		
HP:0008282	biolink:PhenotypicFeature	Unconjugated hyperbilirubinemia	An increased amount of unconjugated (indirect) bilurubin in the blood.	SNOMEDCT_US:7752002|UMLS:C0268306	hp.json		http://purl.obolibrary.org/obo/HP_0008282		
HP:0008281	biolink:PhenotypicFeature	Acute hyperammonemia	An increased concentration of ammonia in the blood with sudden onset.	UMLS:C1859506	hp.json	Hyperammonemia, acute	http://purl.obolibrary.org/obo/HP_0008281		
HP:0008283	biolink:PhenotypicFeature	Fasting hyperinsulinemia	An increased concentration of insulin in the blood in the fasting state, i.e., not as the response to food intake.	UMLS:C1864954	hp.json	High blood insulin levels while fasting	http://purl.obolibrary.org/obo/HP_0008283		
UBERON:0035642	biolink:AnatomicalEntity	laryngeal nerve	Any nerve that innervates the larynx.	SCTID:307013006|MESH:D007823	hp.json		http://purl.obolibrary.org/obo/UBERON_0035642		
UBERON:0035639	biolink:AnatomicalEntity	ocular adnexa	The parts of the orbital region that are outside of the the eyeball, including the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.	FMA:76554|SCTID:120612006|UMLS:C0229243|Wikipedia:Accessory_visual_structures|NCIT:C32574	hp.json	accessory visual structures|appendages of the eye|accessory parts of orbital region|appendages of the eye|accessory visual structures|structurae oculi accessoriae|adnexa oculi|appendage of eye|accessory visual structures|set of accessory visual structures|adnexa oculi|eye adnexa|structurae oculi accessoriae|appendage of eye|adnexal parts of orbital region|accessory visual structures set	http://purl.obolibrary.org/obo/UBERON_0035639		
HP:0008279	biolink:PhenotypicFeature	Transient hyperlipidemia		UMLS:C1850722	hp.json		http://purl.obolibrary.org/obo/HP_0008279		
HP:0008278	biolink:PhenotypicFeature	Cerebellar cortical atrophy	Atrophy (wasting) of the cerebellar cortex.	UMLS:C4024710	hp.json	Cerebellar cortex degeneration	http://purl.obolibrary.org/obo/HP_0008278		
HP:0008275	biolink:PhenotypicFeature	Abnormal light-adapted electroretinogram		UMLS:C4024712	hp.json	Abnormal cone-mediated electroretinogram	http://purl.obolibrary.org/obo/HP_0008275		
HP:0008277	biolink:PhenotypicFeature	Abnormal blood zinc concentration	An abnormality of zinc ion homeostasis.	UMLS:C4020802|UMLS:C4024711	hp.json	Abnormal zinc metabolism|Abnormality of zinc homeostasis	http://purl.obolibrary.org/obo/HP_0008277		
HP:0008293	biolink:PhenotypicFeature	Long-chain dicarboxylic aciduria	An increase in the level of long-chain dicarboxylic acid in the urine.	UMLS:C1837273	hp.json		http://purl.obolibrary.org/obo/HP_0008293		
HP:0008291	biolink:PhenotypicFeature	Pituitary corticotropic cell adenoma	A type of pituitary adenoma that produces adrenocorticotropic hormone (ACTH).	SNOMEDCT_US:254958004|MSH:D049913|SNOMEDCT_US:21109002|UMLS:C1306214	hp.json	ACTH-producing pituitary adenoma|Corticotropin-secreting pituitary adenoma	http://purl.obolibrary.org/obo/HP_0008291		
HP:0008290	biolink:PhenotypicFeature	Partial complement factor H deficiency	A partial reduction in level of the complement component Factor H in circulation.	UMLS:C4024708	hp.json		http://purl.obolibrary.org/obo/HP_0008290		
UBERON:0035650	biolink:AnatomicalEntity	nerve of clitoris	Any nerve that innervates the clitoris.	EMAPA:35044	hp.json	clitoral nerve|clitoris nerve	http://purl.obolibrary.org/obo/UBERON_0035650		
UBERON:0035652	biolink:AnatomicalEntity	fibular nerve	Any nerve that innervates the fibularis. Includes the common fibular nerve, and its branches.	EMAPA:36511|MESH:D010543	hp.json	peroneal nerve	http://purl.obolibrary.org/obo/UBERON_0035652		grouping_class
UBERON:0035651	biolink:AnatomicalEntity	glans			hp.json		http://purl.obolibrary.org/obo/UBERON_0035651		
UBERON:0035649	biolink:AnatomicalEntity	nerve of penis	Any nerve that innervates the penis.	EMAPA:35057	hp.json	penile nerve|penis nerve	http://purl.obolibrary.org/obo/UBERON_0035649		
UBERON:0035648	biolink:AnatomicalEntity	nerve innervating pinna	Any nerve that innervates the pinna.	EMAPA:36513|MA:0001232	hp.json	auricular nerve	http://purl.obolibrary.org/obo/UBERON_0035648		
HP:0008285	biolink:PhenotypicFeature	Transient hypophosphatemia		UMLS:C4024709	hp.json		http://purl.obolibrary.org/obo/HP_0008285		
HP:0008288	biolink:PhenotypicFeature	Nonketotic hyperglycinemia		SNOMEDCT_US:237939006|MSH:D020158|UMLS:C0751748	hp.json		http://purl.obolibrary.org/obo/HP_0008288		
HP:0008261	biolink:PhenotypicFeature	Pancreatic islet cell adenoma	The presence of an adenoma of the pancreas with origin in a pancreatic B cell.	UMLS:C1851697	hp.json		http://purl.obolibrary.org/obo/HP_0008261		
GO:0097096	biolink:BiologicalProcess	facial suture morphogenesis	The process in which any suture between facial bones is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0097096		
UBERON:0035662	biolink:AnatomicalEntity	parotid vein		FMA:50919	hp.json	parotid branch of facial vein|anterior parotid vein	http://purl.obolibrary.org/obo/UBERON_0035662		human_reference_atlas
GO:0097094	biolink:BiologicalProcess	craniofacial suture morphogenesis	The process in which any suture between cranial and/or facial bones is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0097094		
CHEBI:63436	biolink:ChemicalSubstance	carbohydrate acid derivative	A carbohydrate derivative that is formally obtained from a carbohydrate acid.		hp.json	carbohydrate acid derivatives	http://purl.obolibrary.org/obo/CHEBI_63436		3_STAR
GO:0036093	biolink:BiologicalProcess	germ cell proliferation	The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0036093		
GO:0036094	biolink:MolecularActivity	small molecule binding	Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule.		hp.json		http://purl.obolibrary.org/obo/GO_0036094		goslim_agr|goslim_flybase_ribbon
HP:0008256	biolink:PhenotypicFeature	Adrenocortical adenoma	Adrenocortical adenomas are benign tumors of the adrenal cortex.	MSH:D018246|UMLS:C0206667|SNOMEDCT_US:302826002|SNOMEDCT_US:18365006|SNOMEDCT_US:255036008	hp.json	Adrenocortical adenomas	http://purl.obolibrary.org/obo/HP_0008256		
HP:0008259	biolink:PhenotypicFeature	Adrenocorticotropin receptor defect	Adrenal insufficiency secondary to a defect in the ACTH receptor.	UMLS:C4021548	hp.json	ACTH receptor defect|Adrenocorticotropic hormone-resistant adrenal insufficiency|ACTHR defect	http://purl.obolibrary.org/obo/HP_0008259		
HP:0008258	biolink:PhenotypicFeature	Congenital adrenal hyperplasia	A type of adrenal hyperplasia with congenital onset.	SNOMEDCT_US:237751000|UMLS:C0001627|MSH:D000312	hp.json		http://purl.obolibrary.org/obo/HP_0008258		
HP:0008255	biolink:PhenotypicFeature	Transient neonatal diabetes mellitus		SNOMEDCT_US:237603002|UMLS:C0342273	hp.json		http://purl.obolibrary.org/obo/HP_0008255		
HP:0008271	biolink:PhenotypicFeature	Abnormal cartilage collagen	Abnormal morphology of collagen fibers in cartilage. In cartilage, collagen II, actually a collagen II:IX:XI heterofibril, is by far the most important type of collagen. A number of abnormalities may be appreciated by electron micrography or biochemical investigations, including sparse collagen fibers in the cartilage matrix.	UMLS:C4021847|UMLS:C4020804|UMLS:C4020803	hp.json	Abnormal type II collagen|Abnormal hyaline collagen	http://purl.obolibrary.org/obo/HP_0008271		
HP:0008273	biolink:PhenotypicFeature	Transient aminoaciduria		UMLS:C4024713	hp.json		http://purl.obolibrary.org/obo/HP_0008273		
HP:0008272	biolink:PhenotypicFeature	Renal tubular lysine transport defect		UMLS:C4024714	hp.json		http://purl.obolibrary.org/obo/HP_0008272		
HP:0008269	biolink:PhenotypicFeature	Increased red cell hemolysis by shear stress		UMLS:C3806125	hp.json		http://purl.obolibrary.org/obo/HP_0008269		
HP:0008264	biolink:PhenotypicFeature	Neutrophil inclusion bodies	The presence of intracellular inclusion bodies (aggregates of stainable substances, usually proteins) in neutrophils. Cytoplasmic neutrophil inclusions (oval, basophilic) are also known as Doehle bodies.	UMLS:C4021547	hp.json		http://purl.obolibrary.org/obo/HP_0008264		
HP:0008263	biolink:PhenotypicFeature	Thyroid defect in oxidation and organification of iodide		UMLS:C1848800	hp.json		http://purl.obolibrary.org/obo/HP_0008263		
HP:0008265	biolink:PhenotypicFeature	Mitochondrial lysine transport defect		UMLS:C4024715	hp.json		http://purl.obolibrary.org/obo/HP_0008265		
GO:0048066	biolink:BiologicalProcess	developmental pigmentation	The developmental process that results in the deposition of coloring matter in an organism, tissue or cell.		hp.json	pigmentation during development	http://purl.obolibrary.org/obo/GO_0048066		
GO:0061040	biolink:BiologicalProcess	female gonad morphogenesis	The process in which a female gonad is generated and organized.		hp.json	ovary morphogenesis	http://purl.obolibrary.org/obo/GO_0061040		
GO:1903226	biolink:BiologicalProcess	positive regulation of endodermal cell differentiation	Any process that activates or increases the frequency, rate or extent of endodermal cell differentiation.		hp.json	up-regulation of endoderm cell differentiation|up regulation of endoderm cell differentiation|upregulation of endodermal cell differentiation|activation of endoderm cell differentiation|positive regulation of endoderm cell differentiation|upregulation of endoderm cell differentiation|up-regulation of endodermal cell differentiation|up regulation of endodermal cell differentiation|activation of endodermal cell differentiation	http://purl.obolibrary.org/obo/GO_1903226		
GO:0061041	biolink:BiologicalProcess	regulation of wound healing	Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.		hp.json		http://purl.obolibrary.org/obo/GO_0061041		
GO:1903225	biolink:BiologicalProcess	negative regulation of endodermal cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of endodermal cell differentiation.		hp.json	down-regulation of endodermal cell differentiation|down regulation of endodermal cell differentiation|negative regulation of endoderm cell differentiation|down-regulation of endoderm cell differentiation|downregulation of endodermal cell differentiation|inhibition of endodermal cell differentiation|down regulation of endoderm cell differentiation|downregulation of endoderm cell differentiation|inhibition of endoderm cell differentiation	http://purl.obolibrary.org/obo/GO_1903225		
GO:1903224	biolink:BiologicalProcess	regulation of endodermal cell differentiation	Any process that modulates the frequency, rate or extent of endodermal cell differentiation.		hp.json	regulation of endoderm cell differentiation	http://purl.obolibrary.org/obo/GO_1903224		
GO:0061045	biolink:BiologicalProcess	negative regulation of wound healing	Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.		hp.json		http://purl.obolibrary.org/obo/GO_0061045		
HP:0011818	biolink:PhenotypicFeature	Nasofrontal encephalocele		SNOMEDCT_US:253106003|UMLS:C0431291	hp.json	Naso-frontal encephalocele	http://purl.obolibrary.org/obo/HP_0011818		
GO:0061046	biolink:BiologicalProcess	regulation of branching involved in lung morphogenesis	Any process that modulates the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.		hp.json		http://purl.obolibrary.org/obo/GO_0061046		
GO:1903232	biolink:BiologicalProcess	melanosome assembly	The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.		hp.json	melanosome formation	http://purl.obolibrary.org/obo/GO_1903232		
HP:0011819	biolink:PhenotypicFeature	Submucous cleft soft palate	A cleft of the muscular (soft) portion of the palate that is covered by mucous membrane. Soft-palate submucous clefts are characterized by a midline deficiency or lack of muscle tissue.	UMLS:C4023175	hp.json	Submucous cleft velum|Partial thickness cleft soft palate	http://purl.obolibrary.org/obo/HP_0011819		hposlim_core
GO:0061047	biolink:BiologicalProcess	positive regulation of branching involved in lung morphogenesis	Any process that increases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.		hp.json		http://purl.obolibrary.org/obo/GO_0061047		
GO:0061048	biolink:BiologicalProcess	negative regulation of branching involved in lung morphogenesis	Any process that decreases the rate, frequency, or extent of the process in which a highly ordered sequence of patterning events generates the branched structures of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.		hp.json		http://purl.obolibrary.org/obo/GO_0061048		
GO:0061049	biolink:BiologicalProcess	cell growth involved in cardiac muscle cell development	The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.		hp.json	cardiac muscle cell hypertrophy|cardiomyocyte growth|heart muscle cell growth	http://purl.obolibrary.org/obo/GO_0061049		
UBERON:0011628	biolink:AnatomicalEntity	early premaxilla		EHDAA2:0001495	hp.json	future premaxilla	http://purl.obolibrary.org/obo/UBERON_0011628		
HP:0011810	biolink:PhenotypicFeature	Impaired two-point discrimination	A reduced ability to distinguish tactile sensations at points that are very close to one another. This can be tested by using special calipers whose points can be set from 2mm to several centimeters apart.	UMLS:C4023178	hp.json		http://purl.obolibrary.org/obo/HP_0011810		
HP:0011811	biolink:PhenotypicFeature	Impaired touch localization	A reduced ability to identify precisely the site of a touch. This test is usually carried out by asking a patient, whose eyes are closed or covered, to touch the same site with a fingertip.	UMLS:C4021120	hp.json	Impaired touch localisation|Impaired topognosis	http://purl.obolibrary.org/obo/HP_0011811		
GO:0048070	biolink:BiologicalProcess	regulation of developmental pigmentation	Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.		hp.json	regulation of pigmentation during development	http://purl.obolibrary.org/obo/GO_0048070		
HP:0011812	biolink:PhenotypicFeature	Agraphesthesia	Impaired ability to recognize letters or numbers drawn by an examiner's fingertip on the patient's skin (the patients eyes are closed or covered throughout this examination).	UMLS:C1328618	hp.json		http://purl.obolibrary.org/obo/HP_0011812		
HP:0011813	biolink:PhenotypicFeature	Increased cerebral lipofuscin	Lipofuscin (age pigment) is a brown-yellow, electron-dense, autofluorescent material that accumulates progressively over time in lysosomes of postmitotic cells, such as neurons and cardiac myocytes. This term pertains if there is an increase in the accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient.	UMLS:C4023177	hp.json		http://purl.obolibrary.org/obo/HP_0011813		
HP:0011814	biolink:PhenotypicFeature	Increased urinary hypoxanthine	An increased level of hypoxanthine in the urine.	UMLS:C3810487	hp.json		http://purl.obolibrary.org/obo/HP_0011814		
HP:0011815	biolink:PhenotypicFeature	Cephalocele	A congenital defect in the skull, whereby there is a protrusion of part of the cranial contents through a congenital defect in the cranium, usually covered with skin or mucous membrane. The term encephalocele refers to a subclass of these lesions in which brain tissue protrudes through the defect.	SNOMEDCT_US:48777005|UMLS:C0014065|SNOMEDCT_US:55999004|SNOMEDCT_US:253101008|MSH:D004677	hp.json		http://purl.obolibrary.org/obo/HP_0011815		
HP:0011816	biolink:PhenotypicFeature	Parietal encephalocele	An encephalocele located between bregma and lambda.	SNOMEDCT_US:253109005|UMLS:C0431294	hp.json		http://purl.obolibrary.org/obo/HP_0011816		
HP:0011817	biolink:PhenotypicFeature	Basal encephalocele	Basal encephalocele is an encephalocele that occurs along the cribriform plate or through the sphenoid bone. The mass may appear in the nasal cavity, nasopharynx, epipharynx, sphenoid sinus, posterior orbit, or pterygopalatine fossa. The important distinction from other types is that no external tumor is visible except in those rare instances of herniations so large that they protrude through the mouth or nares.	UMLS:C4023176	hp.json		http://purl.obolibrary.org/obo/HP_0011817		
CHEBI:133748	biolink:ChemicalSubstance	citrate anion	A tricarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of citric acid.		hp.json	citrate|citrate anions	http://purl.obolibrary.org/obo/CHEBI_133748		3_STAR
GO:0061032	biolink:BiologicalProcess	visceral serous pericardium development	The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.		hp.json	epicardium development	http://purl.obolibrary.org/obo/GO_0061032		
GO:0061035	biolink:BiologicalProcess	regulation of cartilage development	Any process that modulates the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.		hp.json		http://purl.obolibrary.org/obo/GO_0061035		
HP:0011807	biolink:PhenotypicFeature	Type 1 muscle fiber atrophy	Atrophy (wasting) affecting primary type 1 muscle fibers. This feature in general can only be observed on muscle biopsy.	UMLS:C4023180	hp.json	Type 1 muscle fibre atrophy	http://purl.obolibrary.org/obo/HP_0011807		
HP:0011808	biolink:PhenotypicFeature	Decreased patellar reflex	Decreased intensity of the patellar reflex (also known as the knee jerk reflex).	UMLS:C3277184	hp.json	Decreased knee jerk reflex|Decreased patellar reflexes	http://purl.obolibrary.org/obo/HP_0011808		
GO:0061036	biolink:BiologicalProcess	positive regulation of cartilage development	Any process that increases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.		hp.json		http://purl.obolibrary.org/obo/GO_0061036		
HP:0011809	biolink:PhenotypicFeature	Paradoxical myotonia	A type of myotonia that worsens with repeated muscle contractions.	UMLS:C4023179	hp.json		http://purl.obolibrary.org/obo/HP_0011809		
GO:0061037	biolink:BiologicalProcess	negative regulation of cartilage development	Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.		hp.json		http://purl.obolibrary.org/obo/GO_0061037		
GO:0061038	biolink:BiologicalProcess	uterus morphogenesis	The process in which anatomical structures of the uterus are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0061038		
GO:1905899	biolink:BiologicalProcess	regulation of smooth muscle tissue development	Any process that modulates the frequency, rate or extent of smooth muscle tissue development.		hp.json		http://purl.obolibrary.org/obo/GO_1905899		
UBERON:0035606	biolink:AnatomicalEntity	cartilage of external acoustic meatus		FMA:61298	hp.json	cartilago meatus acustici|cartilage of acoustic meatus|external acoustic meatus cartilage|cartilage of auditory canal	http://purl.obolibrary.org/obo/UBERON_0035606		
GO:0014734	biolink:BiologicalProcess	skeletal muscle hypertrophy	The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.		hp.json		http://purl.obolibrary.org/obo/GO_0014734		
GO:0014733	biolink:BiologicalProcess	regulation of skeletal muscle adaptation	Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.		hp.json	regulation of skeletal muscle plasticity	http://purl.obolibrary.org/obo/GO_0014733		
CHEBI:133744	biolink:ChemicalSubstance	homovanillate	A  hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.		hp.json	(4-hydroxy-3-methoxyphenyl)acetate|3-methoxy-4-hydroxyphenylacetate	http://purl.obolibrary.org/obo/CHEBI_133744		3_STAR
UBERON:0035608	biolink:AnatomicalEntity	dura mater lymph vessel	Any lymph vessel that is located in the dura mater of the brain.		hp.json	dural lymph vessel|dural lymph vasculature	http://purl.obolibrary.org/obo/UBERON_0035608		
HP:0011800	biolink:PhenotypicFeature	Midface retrusion	Posterior positions and/or vertical shortening of the infraorbital and perialar regions, or increased concavity of the face and/or reduced nasolabial angle.	UMLS:C4280321|UMLS:C4280320|UMLS:C1853242|UMLS:C2673410	hp.json	Decreased size of midface|Small midface|Hypoplasia of midface|Midface retrusion|Midface, flat|Underdevelopment of midface|Midface hypoplasia|Decreased projection of midface|Flat midface|Hypotrophic midface|Midface deficiency|Retrusive midface	http://purl.obolibrary.org/obo/HP_0011800		hposlim_core
HP:0011801	biolink:PhenotypicFeature	Enlargement of parotid gland	Increased size of the parotid gland.	SNOMEDCT_US:29748005|UMLS:C0341047	hp.json	Hyperplasia of parotid gland|Increased size of parotid gland|Hypertrophy of parotid gland	http://purl.obolibrary.org/obo/HP_0011801		
HP:0011802	biolink:PhenotypicFeature	Hamartoma of tongue	A benign (noncancerous) tumorlike malformation made up of an abnormal mixture of cells and tissues that originates in the tongue.	SNOMEDCT_US:253753005|UMLS:C0431565	hp.json	Lingual hamartoma	http://purl.obolibrary.org/obo/HP_0011802		
HP:0011803	biolink:PhenotypicFeature	Bifid nose	Visually assessable vertical indentation, cleft, or depression of the nasal bridge, ridge and tip.	UMLS:C0221363|MSH:C535441|SNOMEDCT_US:204521002|UMLS:C4280319|UMLS:C4280318	hp.json	Cleft nasal bridge|Indentation or clefting of the nose|Bifid nasal bridge|Indented bridge of nose|Cleft nose	http://purl.obolibrary.org/obo/HP_0011803		hposlim_core
HP:0011804	biolink:PhenotypicFeature	Abnormal muscle physiology	A functional abnormality of a skeletal muscle.	UMLS:C4023182	hp.json	Issue with muscle function|Abnormality of muscle physiology	http://purl.obolibrary.org/obo/HP_0011804		
HP:0011805	biolink:PhenotypicFeature	Abnormal skeletal muscle morphology	A structural abnormality of a skeletal muscle.	UMLS:C4023181	hp.json	Abnormal muscle morphology|Issue with muscle structure|Abnormally shaped muscle|Abnormality of muscle morphology	http://purl.obolibrary.org/obo/HP_0011805		
GO:0002759	biolink:BiologicalProcess	regulation of antimicrobial humoral response	Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.		hp.json		http://purl.obolibrary.org/obo/GO_0002759		
CHEBI:38497	biolink:ChemicalSubstance	respiratory-chain inhibitor			hp.json		http://purl.obolibrary.org/obo/CHEBI_38497		1_STAR
CHEBI:38496	biolink:ChemicalSubstance	electron-transport chain inhibitor			hp.json		http://purl.obolibrary.org/obo/CHEBI_38496		1_STAR
GO:0002720	biolink:BiologicalProcess	positive regulation of cytokine production involved in immune response	Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.		hp.json	activation of cytokine production during immune response|up regulation of cytokine production during immune response|positive regulation of cytokine biosynthetic process involved in immune response|up-regulation of cytokine production during immune response|positive regulation of cytokine secretion involved in immune response|positive regulation of cytokine production during immune response|upregulation of cytokine production during immune response|stimulation of cytokine production during immune response	http://purl.obolibrary.org/obo/GO_0002720		
GO:0099632	biolink:BiologicalProcess	protein transport within plasma membrane	A process in which protein is transported from one region of the plasma membrane to another.		hp.json		http://purl.obolibrary.org/obo/GO_0099632		
GO:0048087	biolink:BiologicalProcess	positive regulation of developmental pigmentation	Any process that increases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.		hp.json	up regulation of developmental pigmentation|upregulation of developmental pigmentation|stimulation of developmental pigmentation|up-regulation of developmental pigmentation|activation of developmental pigmentation	http://purl.obolibrary.org/obo/GO_0048087		
GO:0048086	biolink:BiologicalProcess	negative regulation of developmental pigmentation	Any process that decreases the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.		hp.json	down regulation of developmental pigmentation|down-regulation of developmental pigmentation|inhibition of pigmentation|downregulation of developmental pigmentation	http://purl.obolibrary.org/obo/GO_0048086		
NCBITaxon:4751	biolink:OrganismalEntity	Fungi		PMID:11062127|PMID:12684019|GC_ID:1	hp.json	Mycota|fungi	http://purl.obolibrary.org/obo/NCBITaxon_4751		
CHEBI:51446	biolink:ChemicalSubstance	organic divalent group			hp.json		http://purl.obolibrary.org/obo/CHEBI_51446		1_STAR
CHEBI:51447	biolink:ChemicalSubstance	organic univalent group			hp.json		http://purl.obolibrary.org/obo/CHEBI_51447		1_STAR
GO:0014706	biolink:BiologicalProcess	striated muscle tissue development	The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.		hp.json		http://purl.obolibrary.org/obo/GO_0014706		
GO:0061061	biolink:BiologicalProcess	muscle structure development	The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.		hp.json		http://purl.obolibrary.org/obo/GO_0061061		goslim_drosophila
GO:0085029	biolink:BiologicalProcess	extracellular matrix assembly	The aggregation, arrangement and bonding together of the extracellular matrix.		hp.json		http://purl.obolibrary.org/obo/GO_0085029		
UBERON:0011602	biolink:AnatomicalEntity	gingiva of lower jaw	A gingiva that is part of a lower jaw region.	NCIT:C54204|EMAPA:18967|FMA:59764	hp.json	lower jaw gum|lower gum|lower jaw gingiva|lower gingiva|gum of lower jaw|mandibular gum|gum of mandible	http://purl.obolibrary.org/obo/UBERON_0011602		pheno_slim
UBERON:0011601	biolink:AnatomicalEntity	gingiva of upper jaw	A gingiva that is part of a upper jaw region.	FMA:59763|NCIT:C54205|EMAPA:18970	hp.json	gum of upper jaw|maxillary gum|upper gum|upper jaw gingiva|upper gingiva|gum of maxilla	http://purl.obolibrary.org/obo/UBERON_0011601		pheno_slim
UBERON:0011607	biolink:AnatomicalEntity	hyomandibular cartilage	Cartilage form of the hyomandibular element.	ZFA:0001422|TAO:0001422|VHOG:0000688|EFO:0003686	hp.json	symplectic cartilage|hyosymplectic cartilage	http://purl.obolibrary.org/obo/UBERON_0011607		efo_slim
UBERON:0011606	biolink:AnatomicalEntity	hyomandibular bone	Replacement bone that is bilaterally paired and (in teleosts) articulates with the neurocranium dorsally and the opercle posteriorly[TAO,modified].	ZFA:0000672|TAO:0000672|EFO:0003556|VHOG:0000688	hp.json	hyomandibular|hyomandibula	http://purl.obolibrary.org/obo/UBERON_0011606		efo_slim
UBERON:0011608	biolink:AnatomicalEntity	hyomandibular element	The upper paired deep bone or cartilage of the hyoid region, sometimes taking part in jaw suspension and which supports the opercle. Dorsally it articulates with the otic capsule at the hyomandibular fossa, ventrally with the quadrate and symplectic. In most Teleostei it has a foramen for the hyomandibular branch of the facial nerve (VII).	TAO:0000672|VHOG:0000688	hp.json	hyomandibula|hyomandibula element|hyomandibula - stapes|epihyal	http://purl.obolibrary.org/obo/UBERON_0011608		
GO:0002724	biolink:BiologicalProcess	regulation of T cell cytokine production	Any process that modulates the frequency, rate, or extent of T cell cytokine production.		hp.json	regulation of T-cell cytokine production|regulation of T lymphocyte cytokine production|regulation of T-lymphocyte cytokine production	http://purl.obolibrary.org/obo/GO_0002724		
GO:0002725	biolink:BiologicalProcess	negative regulation of T cell cytokine production	Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.		hp.json	down regulation of T cell cytokine production|inhibition of T cell cytokine production|down-regulation of T cell cytokine production|negative regulation of T-cell cytokine production|negative regulation of T lymphocyte cytokine production|negative regulation of T-lymphocyte cytokine production|downregulation of T cell cytokine production	http://purl.obolibrary.org/obo/GO_0002725		
GO:0002726	biolink:BiologicalProcess	positive regulation of T cell cytokine production	Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.		hp.json	upregulation of T cell cytokine production|up regulation of T cell cytokine production|stimulation of T cell cytokine production|positive regulation of T-cell cytokine production|positive regulation of T lymphocyte cytokine production|up-regulation of T cell cytokine production|activation of T cell cytokine production|positive regulation of T-lymphocyte cytokine production	http://purl.obolibrary.org/obo/GO_0002726		
GO:0099643	biolink:BiologicalProcess	signal release from synapse	Any signal release from a synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099643		goslim_synapse
GO:0002731	biolink:BiologicalProcess	negative regulation of dendritic cell cytokine production	Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.		hp.json	downregulation of dendritic cell cytokine production|down regulation of dendritic cell cytokine production|inhibition of dendritic cell cytokine production|down-regulation of dendritic cell cytokine production	http://purl.obolibrary.org/obo/GO_0002731		
GO:0002732	biolink:BiologicalProcess	positive regulation of dendritic cell cytokine production	Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.		hp.json	up regulation of dendritic cell cytokine production|stimulation of dendritic cell cytokine production|up-regulation of dendritic cell cytokine production|activation of dendritic cell cytokine production|upregulation of dendritic cell cytokine production	http://purl.obolibrary.org/obo/GO_0002732		
GO:0002733	biolink:BiologicalProcess	regulation of myeloid dendritic cell cytokine production	Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.		hp.json		http://purl.obolibrary.org/obo/GO_0002733		
GO:0099641	biolink:BiologicalProcess	anterograde axonal protein transport	The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.		hp.json	anterograde axon cargo transport	http://purl.obolibrary.org/obo/GO_0099641		goslim_synapse
GO:0099642	biolink:BiologicalProcess	retrograde axonal protein transport	The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons.		hp.json	retrograde axon cargo transport	http://purl.obolibrary.org/obo/GO_0099642		goslim_synapse
GO:0002734	biolink:BiologicalProcess	negative regulation of myeloid dendritic cell cytokine production	Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production.		hp.json	down regulation of myeloid dendritic cell cytokine production|inhibition of myeloid dendritic cell cytokine production|down-regulation of myeloid dendritic cell cytokine production|downregulation of myeloid dendritic cell cytokine production	http://purl.obolibrary.org/obo/GO_0002734		
GO:0099640	biolink:BiologicalProcess	axo-dendritic protein transport	The directed movement of proteins along microtubules in neuron projections.		hp.json	axonal protein transport	http://purl.obolibrary.org/obo/GO_0099640		goslim_synapse
GO:0002730	biolink:BiologicalProcess	regulation of dendritic cell cytokine production	Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.		hp.json		http://purl.obolibrary.org/obo/GO_0002730		
GO:0061050	biolink:BiologicalProcess	regulation of cell growth involved in cardiac muscle cell development	Any process that modulates the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.		hp.json		http://purl.obolibrary.org/obo/GO_0061050		
GO:0061051	biolink:BiologicalProcess	positive regulation of cell growth involved in cardiac muscle cell development	Any process that increases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.		hp.json		http://purl.obolibrary.org/obo/GO_0061051		
GO:0061052	biolink:BiologicalProcess	negative regulation of cell growth involved in cardiac muscle cell development	Any process that decreases the rate, frequency, or extent of the growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.		hp.json		http://purl.obolibrary.org/obo/GO_0061052		
GO:0061053	biolink:BiologicalProcess	somite development	The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.		hp.json		http://purl.obolibrary.org/obo/GO_0061053		
GO:0061054	biolink:BiologicalProcess	dermatome development	The progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.		hp.json		http://purl.obolibrary.org/obo/GO_0061054		
GO:0061055	biolink:BiologicalProcess	myotome development	The progression of the myotome over time, from its formation to the mature structure. The myotome is the portion of the somite that will give rise to muscle.		hp.json		http://purl.obolibrary.org/obo/GO_0061055		
GO:0061056	biolink:BiologicalProcess	sclerotome development	The progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.		hp.json		http://purl.obolibrary.org/obo/GO_0061056		
GO:0002735	biolink:BiologicalProcess	positive regulation of myeloid dendritic cell cytokine production	Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.		hp.json	upregulation of myeloid dendritic cell cytokine production|stimulation of myeloid dendritic cell cytokine production|up regulation of myeloid dendritic cell cytokine production|activation of myeloid dendritic cell cytokine production|up-regulation of myeloid dendritic cell cytokine production	http://purl.obolibrary.org/obo/GO_0002735		
GO:0002700	biolink:BiologicalProcess	regulation of production of molecular mediator of immune response	Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.		hp.json		http://purl.obolibrary.org/obo/GO_0002700		
GO:0002701	biolink:BiologicalProcess	negative regulation of production of molecular mediator of immune response	Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.		hp.json	down-regulation of production of molecular mediator of immune response|down regulation of production of molecular mediator of immune response|inhibition of production of molecular mediator of immune response|downregulation of production of molecular mediator of immune response	http://purl.obolibrary.org/obo/GO_0002701		
CHEBI:51422	biolink:ChemicalSubstance	organodiyl group	Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s).		hp.json	organodiyl groups	http://purl.obolibrary.org/obo/CHEBI_51422		3_STAR
HP:0011850	biolink:PhenotypicFeature	Parotitis	Inflammation of the parotid gland.	UMLS:C0030583|MSH:D010309|SNOMEDCT_US:14756005	hp.json		http://purl.obolibrary.org/obo/HP_0011850		
HP:0011851	biolink:PhenotypicFeature	Hemopericardium	Accumulation of blood within the pericardial sac.	UMLS:C0019064|MSH:D010490|SNOMEDCT_US:23412002	hp.json		http://purl.obolibrary.org/obo/HP_0011851		
HP:0011852	biolink:PhenotypicFeature	Chylopericardium	Accumulation of chyle (the whitish fluid taken up by the lacteals in the intestine, consisting of an emulsion of lymph and triglyceride fat thatpasses into the veins by the thoracic duct) in the pericardium. Chylopericardium is generally caused by obstruction of or trauma to the thoracic duct.	MSH:D010490|SNOMEDCT_US:233890005|UMLS:C0242426	hp.json		http://purl.obolibrary.org/obo/HP_0011852		
GO:0061080	biolink:BiologicalProcess	right horn of sinus venosus development	The progression of the right horn of the sinus venosus from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0061080		
GO:0061081	biolink:BiologicalProcess	positive regulation of myeloid leukocyte cytokine production involved in immune response	Any process that modulates the rate, frequency, or extent of the production of a cytokine that contributes to the immune response.		hp.json	positive regulation of myeloid cell cytokine production involved in immune response	http://purl.obolibrary.org/obo/GO_0061081		
NCBITaxon:2157	biolink:OrganismalEntity	Archaea		PMID:11542149|PMID:2112744|PMID:10843050|PMID:10939673|PMID:10939651|PMID:11211268|PMID:11321113|PMID:10490293|PMID:25527841|PMID:10425797|PMID:270744|PMID:10425796|PMID:11411719|PMID:8123559|PMID:10425795|PMID:11542064|GC_ID:11|PMID:11321083|PMID:11540071|PMID:9336922|PMID:11760965|PMID:9103655|PMID:10939677|PMID:8590690|PMID:11541975|PMID:12054223	hp.json	Procaryotae|Archaebacteria|Monera|prokaryote|Metabacteria|Prokaryotae|Prokaryota|Mendosicutes|archaea|prokaryotes	http://purl.obolibrary.org/obo/NCBITaxon_2157		
HP:0011853	biolink:PhenotypicFeature	Serous pericardial effusion	Accumulation of serous fluid (pale yellow and transparent fluid) in the pericardial sac.	UMLS:C4023160	hp.json		http://purl.obolibrary.org/obo/HP_0011853		
CHEBI:26469	biolink:ChemicalSubstance	quaternary nitrogen compound	A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen.		hp.json		http://purl.obolibrary.org/obo/CHEBI_26469		3_STAR
GO:0061082	biolink:BiologicalProcess	myeloid leukocyte cytokine production	Any process that contributes to cytokine production by a myeloid cell.		hp.json		http://purl.obolibrary.org/obo/GO_0061082		gocheck_do_not_annotate
CHEBI:26463	biolink:ChemicalSubstance	pyruvate family amino acid	An L-alpha-amino acid which is biosynthesised from pyruvate (i.e. alanine, valine, and leucine). A closed class.		hp.json	pyruvate family amino acids	http://purl.obolibrary.org/obo/CHEBI_26463		3_STAR
UBERON:0011676	biolink:AnatomicalEntity	subdivision of organism along main body axis	A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column.		hp.json	axial subdivision of organism|body segment|main body segment	http://purl.obolibrary.org/obo/UBERON_0011676		upper_level
HP:0011854	biolink:PhenotypicFeature	Hemoperitoneum	Accumulation of blood in the peritoneal cavity owing to internal hemorrhage.	UMLS:C0019065|UMLS:C0744735|MSH:D006465|SNOMEDCT_US:443826006|SNOMEDCT_US:45626005	hp.json	Hematoperitoneum	http://purl.obolibrary.org/obo/HP_0011854		
GO:0002706	biolink:BiologicalProcess	regulation of lymphocyte mediated immunity	Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.		hp.json		http://purl.obolibrary.org/obo/GO_0002706		
HP:0011855	biolink:PhenotypicFeature	Pharyngeal edema	Abnormal accumulation of fluid leading to swelling of the pharynx.	SNOMEDCT_US:2129002|UMLS:C0236024	hp.json	Swollen throat|Pharyngeal oedema|Throat swelling	http://purl.obolibrary.org/obo/HP_0011855		
GO:0002707	biolink:BiologicalProcess	negative regulation of lymphocyte mediated immunity	Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.		hp.json	downregulation of lymphocyte mediated immunity|down regulation of lymphocyte mediated immunity|inhibition of lymphocyte mediated immunity|down-regulation of lymphocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002707		
HP:0011856	biolink:PhenotypicFeature	Pica	An appetite for and the persistent ingestion of non-food substances such as clay. In order to diagnose pica, this behavior must have persisted over a period of at least one month.	UMLS:C0031873|SNOMEDCT_US:14077003|MSH:D010842	hp.json		http://purl.obolibrary.org/obo/HP_0011856		
GO:0002708	biolink:BiologicalProcess	positive regulation of lymphocyte mediated immunity	Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.		hp.json	stimulation of lymphocyte mediated immunity|up regulation of lymphocyte mediated immunity|up-regulation of lymphocyte mediated immunity|activation of lymphocyte mediated immunity|upregulation of lymphocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002708		
GO:0002709	biolink:BiologicalProcess	regulation of T cell mediated immunity	Any process that modulates the frequency, rate, or extent of T cell mediated immunity.		hp.json	regulation of T-lymphocyte mediated immunity|regulation of T-cell mediated immunity|regulation of T lymphocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002709		
HP:0011857	biolink:PhenotypicFeature	Plasmacytoma	A discrete mass of neoplastic monoclonal plasma cells either in the bone marrow or in an extramedullary location.	SNOMEDCT_US:10639003|UMLS:C0032131|SNOMEDCT_US:415112005|MSH:D010954	hp.json		http://purl.obolibrary.org/obo/HP_0011857		
HP:0011858	biolink:PhenotypicFeature	Reduced factor IX activity	Decreased activity of coagulation factor IX. Factor IX, which itself is activated by factor Xa or factor VIIa to form factor IXa, activates factor X into factor Xa.	UMLS:C4023159	hp.json	Low factor IX activity	http://purl.obolibrary.org/obo/HP_0011858		
GO:0002702	biolink:BiologicalProcess	positive regulation of production of molecular mediator of immune response	Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.		hp.json	stimulation of production of molecular mediator of immune response|upregulation of production of molecular mediator of immune response|up-regulation of production of molecular mediator of immune response|up regulation of production of molecular mediator of immune response|activation of production of molecular mediator of immune response	http://purl.obolibrary.org/obo/GO_0002702		
HP:0011859	biolink:PhenotypicFeature	Punctate keratitis	A type of keratitis characterized by inflammation in pinpoint areas of the corneal epithelium.	UMLS:C1562761|SNOMEDCT_US:416300008	hp.json		http://purl.obolibrary.org/obo/HP_0011859		
CHEBI:38443	biolink:ChemicalSubstance	1-benzopyran			hp.json	1-benzopyrans	http://purl.obolibrary.org/obo/CHEBI_38443		3_STAR
GO:0002703	biolink:BiologicalProcess	regulation of leukocyte mediated immunity	Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.		hp.json	regulation of immune cell mediated immunity|regulation of leucocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002703		
GO:0002704	biolink:BiologicalProcess	negative regulation of leukocyte mediated immunity	Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.		hp.json	down-regulation of leukocyte mediated immunity|down regulation of leukocyte mediated immunity|downregulation of leukocyte mediated immunity|inhibition of leukocyte mediated immunity|negative regulation of immune cell mediated immunity|negative regulation of leucocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002704		
GO:0002705	biolink:BiologicalProcess	positive regulation of leukocyte mediated immunity	Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.		hp.json	upregulation of leukocyte mediated immunity|positive regulation of immune cell mediated immunity|positive regulation of leucocyte mediated immunity|up-regulation of leukocyte mediated immunity|up regulation of leukocyte mediated immunity|activation of leukocyte mediated immunity|stimulation of leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002705		
GO:0002710	biolink:BiologicalProcess	negative regulation of T cell mediated immunity	Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.		hp.json	negative regulation of T-lymphocyte mediated immunity|downregulation of T cell mediated immunity|down regulation of T cell mediated immunity|inhibition of T cell mediated immunity|down-regulation of T cell mediated immunity|negative regulation of T-cell mediated immunity|negative regulation of T lymphocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002710		
GO:0002711	biolink:BiologicalProcess	positive regulation of T cell mediated immunity	Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.		hp.json	stimulation of T cell mediated immunity|up regulation of T cell mediated immunity|positive regulation of T-cell mediated immunity|positive regulation of T lymphocyte mediated immunity|up-regulation of T cell mediated immunity|activation of T cell mediated immunity|positive regulation of T-lymphocyte mediated immunity|upregulation of T cell mediated immunity	http://purl.obolibrary.org/obo/GO_0002711		
GO:0097048	biolink:BiologicalProcess	dendritic cell apoptotic process	Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.		hp.json	dendritic cell apoptosis	http://purl.obolibrary.org/obo/GO_0097048		
HP:0011840	biolink:PhenotypicFeature	Abnormality of T cell physiology	A functional anomaly of T cells.	UMLS:C4023166	hp.json		http://purl.obolibrary.org/obo/HP_0011840		
HP:0011841	biolink:PhenotypicFeature	Ventricular flutter	A potentially lethal cardiac arrhythmia characterized by an extremely rapid, hemodynamically unstable ventricular tachycardia (150-300 beats/min) with a large oscillating sine-wave appearance.	MSH:D054141|SNOMEDCT_US:111288001|UMLS:C0152173	hp.json		http://purl.obolibrary.org/obo/HP_0011841		
HP:0011842	biolink:PhenotypicFeature	Abnormal skeletal morphology	An abnormality of the form, structure, or size of the skeletal system.	UMLS:C4023165	hp.json	Abnormally shaped skeletal|Abnormality of skeletal morphology	http://purl.obolibrary.org/obo/HP_0011842		
OBO:MAXO_0009069	biolink:NamedThing	vitamin measurement	The determination of the type and/or amount of vitamins in a sample.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009069		
GO:0061072	biolink:BiologicalProcess	iris morphogenesis	The process in which the iris is generated and organized. The iris is an anatomical structure in the eye whose opening forms the pupil. The iris is responsible for controlling the diameter and size of the pupil and the amount of light reaching the retina.		hp.json		http://purl.obolibrary.org/obo/GO_0061072		
GO:0061073	biolink:BiologicalProcess	ciliary body morphogenesis	The process in which the ciliary body generated and organized. The ciliary body is the circumferential tissue inside the eye composed of the ciliary muscle and ciliary processes.		hp.json		http://purl.obolibrary.org/obo/GO_0061073		
OBO:MAXO_0009067	biolink:NamedThing	examination by urologist	A direct appraisal of a patient's condition by a urology specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009067		
OBO:MAXO_0009068	biolink:NamedThing	allied health professional examination	A direct appraisal of a patient's condition by an allied health professional specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json	examination by allied health professional	http://purl.obolibrary.org/obo/MAXO_0009068		
GO:0061074	biolink:BiologicalProcess	regulation of neural retina development	Any process that modulates the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.		hp.json		http://purl.obolibrary.org/obo/GO_0061074		
GO:0061075	biolink:BiologicalProcess	positive regulation of neural retina development	Any process that increases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.		hp.json		http://purl.obolibrary.org/obo/GO_0061075		
OBO:MAXO_0009065	biolink:NamedThing	intravenous pyelogram	A test that involves the administration of intravenous contrast and X-ray imaging of the urinary tract. The iodinated contrast flows through the renal vasculature and filtered into the collecting system highlighting the anatomic structures on the X-ray image.		hp.json	IVP|intravenous urography	http://purl.obolibrary.org/obo/MAXO_0009065		
GO:0061076	biolink:BiologicalProcess	negative regulation of neural retina development	Any process that decreases the rate, frequency, or extent of neural retina development, the progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.		hp.json		http://purl.obolibrary.org/obo/GO_0061076		
OBO:MAXO_0009066	biolink:NamedThing	examination by psychiatrist	A direct appraisal of a patient's condition by a psychiatric specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json	psychiatric examination	http://purl.obolibrary.org/obo/MAXO_0009066		
OBO:MAXO_0009063	biolink:NamedThing	examination by pediatrician	A direct appraisal of a patient's condition by a pediatric specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json	pediatric examination	http://purl.obolibrary.org/obo/MAXO_0009063		
OBO:MAXO_0009064	biolink:NamedThing	examination by physiatrist	A direct appraisal of a patient's condition by a physical medicine and rehabilition specialist that is based on a physical exam, medical history, and the patient's account of symptoms.		hp.json	examination by physical mediciane and rehabilitation specialist	http://purl.obolibrary.org/obo/MAXO_0009064		
HP:0008209	biolink:PhenotypicFeature	Premature ovarian insufficiency	Amenorrhea due to loss of ovarian function before the age of 40. Primary ovarian inssuficiency (POI) is a state of female hypergonadotropic hypogonadism. It can manifest as primary amenorrhea with onset before menarche or secondary amenorrhea.	UMLS:C0025322|MSH:D008594|MSH:D016649|SNOMEDCT_US:373717006|UMLS:C0085215	hp.json	Early menopause|Premature ovarian failure|Primary ovarian insufficiency|Climacterium praecox|Menopause praecox|Hypergonadotropic amenorrhea|Premature menopause	http://purl.obolibrary.org/obo/HP_0008209		
OBO:MAXO_0009070	biolink:NamedThing	single-photon emission computed tomography	Delivery of a gamma-emitting radioisotope (a radionuclide) into the patient, normally through injection into the bloodstream and detected by gamma camera The radioisotope could be is a simple soluble dissolved ion, such as an isotope of gallium(III), or a marker radioisotope is attached to a specific ligand to create a radioligand targeting a place of interest in the body.		hp.json	SPECT	http://purl.obolibrary.org/obo/MAXO_0009070		
OBO:MAXO_0009071	biolink:NamedThing	fat soluble vitamin measurement	The determination of the type and/or amount of fat-soluble vitamins in a sample.		hp.json		http://purl.obolibrary.org/obo/MAXO_0009071		
PR:Q62351	biolink:Protein	transferrin receptor protein 1 (mouse)	A transferrin receptor protein 1 that is encoded in the genome of mouse.	UniProtKB:Q62351	hp.json	CD71 (mouse)|TR (mouse)|Trfr|mTFRC|TfR1 (mouse)|Tfrc|TfR (mouse)	http://purl.obolibrary.org/obo/PR_Q62351		
HP:0008205	biolink:PhenotypicFeature	Insulin-dependent but ketosis-resistant diabetes	Ketosis-resistant diabetes is a synonym for type II diabetes. This term thus refers to a form of type II diabetes in which patients are dependent on insulin.	UMLS:C1842404	hp.json		http://purl.obolibrary.org/obo/HP_0008205		
HP:0008208	biolink:PhenotypicFeature	Parathyroid hyperplasia	Hyperplasia of the parathyroid gland.	UMLS:C0271844|SNOMEDCT_US:9092004	hp.json	Enlarged parathyroid glands	http://purl.obolibrary.org/obo/HP_0008208		
HP:0008207	biolink:PhenotypicFeature	Primary adrenal insufficiency	Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves.	SNOMEDCT_US:373662000|SNOMEDCT_US:363732003|SNOMEDCT_US:386584007|MSH:D000224|UMLS:C0001403|UMLS:C0405580	hp.json	Primary adrenocortical failure|Addison disease|Adrenocortical insufficiency|Addison's disease	http://purl.obolibrary.org/obo/HP_0008207		
HP:0008202	biolink:PhenotypicFeature	Reduced circulating prolactin concentration	A reduced level of prolactin in the blood circulation. Prolactin is a protein hormone that is secreted by lactotrophs in the anterior pituitary and that stimulates mammary gland development and milk production.	UMLS:C0271586|MSH:C562708|SNOMEDCT_US:67873006	hp.json	Prolactin deficiency	http://purl.obolibrary.org/obo/HP_0008202		
HP:0011843	biolink:PhenotypicFeature	Abnormal musculoskeletal physiology	An abnormality of the function of the skeletal system.	UMLS:C4023164	hp.json	Abnormality of musculoskeletal physiology	http://purl.obolibrary.org/obo/HP_0011843		
GO:0002718	biolink:BiologicalProcess	regulation of cytokine production involved in immune response	Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.		hp.json	regulation of cytokine biosynthetic process involved in immune response|regulation of cytokine secretion involved in immune response|regulation of cytokine production during immune response	http://purl.obolibrary.org/obo/GO_0002718		
HP:0011844	biolink:PhenotypicFeature	Abnormal appendicular skeleton morphology	An abnormality of the appendicular skeletal system, consisting of the of the limbs, shoulder and pelvic girdles.	UMLS:C4023163	hp.json		http://purl.obolibrary.org/obo/HP_0011844		
HP:0008204	biolink:PhenotypicFeature	Precocious puberty with Sertoli cell tumor		UMLS:C1868007	hp.json	Precocious puberty with Sertoli cell tumour	http://purl.obolibrary.org/obo/HP_0008204		
HP:0011845	biolink:PhenotypicFeature	Short second metatarsal	Short (hypoplastic) second metatarsal bone.	UMLS:C4023162	hp.json	Short 2nd long bone of foot	http://purl.obolibrary.org/obo/HP_0011845		
GO:0002719	biolink:BiologicalProcess	negative regulation of cytokine production involved in immune response	Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.		hp.json	inhibition of cytokine production during immune response|negative regulation of cytokine secretion involved in immune response|downregulation of cytokine production during immune response|down-regulation of cytokine production during immune response|negative regulation of cytokine production during immune response|negative regulation of cytokine biosynthetic process involved in immune response|down regulation of cytokine production during immune response	http://purl.obolibrary.org/obo/GO_0002719		
HP:0011846	biolink:PhenotypicFeature	Osteoblastoma	A benign, painful, tumor of bone characterized by the formation of osteoid tissue, primitive bone and calcified tissue.	UMLS:C0029417|SNOMEDCT_US:55333008|MSH:D018215	hp.json		http://purl.obolibrary.org/obo/HP_0011846		
HP:0011847	biolink:PhenotypicFeature	Giant cell tumor of bone	A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts.	SNOMEDCT_US:57500000|UMLS:C0206638|MSH:D018212|SNOMEDCT_US:697970009	hp.json	Giant cell tumour of bone	http://purl.obolibrary.org/obo/HP_0011847		
HP:0011848	biolink:PhenotypicFeature	Abdominal colic	A type of abdominal pain that comes and goes in waves, most often starting and ending suddenly and being of severe intensity.	UMLS:C0232488|SNOMEDCT_US:9991008|MSH:D003085	hp.json		http://purl.obolibrary.org/obo/HP_0011848		
GO:0097049	biolink:BiologicalProcess	motor neuron apoptotic process	Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.		hp.json	motor neuron apoptosis|motoneuron apoptosis	http://purl.obolibrary.org/obo/GO_0097049		
HP:0008200	biolink:PhenotypicFeature	Primary hyperparathyroidism	A type of hyperparathyroidism caused by a primary abnormality of the parathyroid glands (e.g., adenoma, carcinoma, hyperplasia). Primary hyperparathyroidism is associated with hyercalcemia.	SNOMEDCT_US:36348003|MSH:D049950|UMLS:C0221002	hp.json		http://purl.obolibrary.org/obo/HP_0008200		
HP:0011849	biolink:PhenotypicFeature	Abnormal bone ossification	Any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.	UMLS:C4280317|MP:0008271|UMLS:C4023161	hp.json	Abnormal bone maturation	http://purl.obolibrary.org/obo/HP_0011849		
GO:0097014	biolink:CellularComponent	ciliary plasm	All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.		hp.json	cilium plasm|microtubule-based flagellar cytoplasm|cilial cytoplasm|microtubule-based flagellar matrix|cilium cytoplasm|microtubule-based flagellum cytoplasm|microtubule-based flagellum matrix|ciliary cytoplasm	http://purl.obolibrary.org/obo/GO_0097014		
HP:0011830	biolink:PhenotypicFeature	Abnormal oral mucosa morphology	Abnormality of the oral mucosa.	UMLS:C4023170	hp.json	Abnormality of oral mucous membrane|Abnormality of mucosa of mouth|Abnormality of lining of mouth|Abnormality of oral mucosa	http://purl.obolibrary.org/obo/HP_0011830		hposlim_core
HP:0011831	biolink:PhenotypicFeature	Deviated nasal tip	Nasal tip positioned to one side of the midline.	UMLS:C4021114|UMLS:C4280271	hp.json	Deviated nasal tip|Nasal tip, deviated|Distortion of the nasal tip|Crooked tip of nose|Asymmetry of tip of nose|Crooked nasal tip|Asymmetry of nasal tip|Deviated tip of nose	http://purl.obolibrary.org/obo/HP_0011831		
CHEBI:26447	biolink:ChemicalSubstance	pyrimidinemonocarboxylic acid			hp.json	pyrimidinemonocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_26447		3_STAR
UBERON:2001950	biolink:AnatomicalEntity	inter-premaxillary joint	Joint that articulates the left and right premaxillary bones. Inter-premaxillary joint is unpaired.	ZFA:0005475	hp.json		http://purl.obolibrary.org/obo/UBERON_2001950		
UBERON:0011645	biolink:AnatomicalEntity	iliofemoralis muscle	Limb extensor that runs from ilium to femur.		hp.json	iliofemoralis	http://purl.obolibrary.org/obo/UBERON_0011645		
UBERON:2001947	biolink:AnatomicalEntity	hyomandibular-otic region joint	Joint that articulates the hyomandibular cartilage or bone and otic region cartilage or sphenotic bone, and often pterotic bone and prootic bone. Hyomandibular-otic region joint is paired.	ZFA:0005544	hp.json		http://purl.obolibrary.org/obo/UBERON_2001947		
GO:1903292	biolink:BiologicalProcess	protein localization to Golgi membrane	A process in which a protein is transported to, or maintained in, a location within a Golgi membrane.		hp.json	protein localisation to Golgi membrane|protein localization in Golgi membrane|protein localisation in Golgi membrane	http://purl.obolibrary.org/obo/GO_1903292		
UBERON:0011648	biolink:AnatomicalEntity	jaw muscle		AAO:0000247|EFO:0003511|ZFA:0000236|XAO:0003269|TAO:0000236	hp.json	mandibular muscle|mandibular muscles	http://purl.obolibrary.org/obo/UBERON_0011648		pheno_slim|efo_slim
HP:0011832	biolink:PhenotypicFeature	Narrow nasal tip	Decrease in width of the nasal tip.	SNOMEDCT_US:249331008|UMLS:C0426433	hp.json	Nasal tip, narrow|Narrow tip of nose|Thin tip of nose|Narrow nasal tip|Pinched tip of nose|Thin nasal tip|Nasal tip, pinched|Pinched nasal tip	http://purl.obolibrary.org/obo/HP_0011832		hposlim_core
HP:0011833	biolink:PhenotypicFeature	Overhanging nasal tip	Positioning of the nasal tip inferior to the nasal base.	UMLS:C0426430|SNOMEDCT_US:249328007	hp.json	Low hanging nasal tip|Hooked tip of nose|Drooping nasal tip|Nasal tip, overhanging|Overhanging nasal tip	http://purl.obolibrary.org/obo/HP_0011833		hposlim_core
UBERON:0008000	biolink:AnatomicalEntity	sesamoid bone of pes	A sesamoid bone that is part of a pes.	FMA:45096	hp.json	sesamoid bone of foot	http://purl.obolibrary.org/obo/UBERON_0008000		
HP:0011834	biolink:PhenotypicFeature	Moyamoya phenomenon	A noninflammatory, progressive occlusion of the intracranial carotid arteries owing to the formation of netlike collateral arteries arising from the circle of Willis.	UMLS:C4023169	hp.json		http://purl.obolibrary.org/obo/HP_0011834		
UBERON:0008001	biolink:AnatomicalEntity	irregular bone	The irregular bones are bones which, from their peculiar form, cannot be grouped as long bone, short bone, flat bone or sesamoid bone. Irregular bones serve various purposes in the body, such as protection of nervous tissue, affording multiple anchor points for skeletal muscle attachment (as with the sacrum), and maintaining pharynx and trachea support, and tongue attachment (such as the hyoid bone). They consist of cancellous tissue enclosed within a thin layer of compact bone. The irregular bones are: the vertebrC&, sacrum, coccyx, temporal, sphenoid, ethmoid, zygomatic, maxilla, mandible, palatine, inferior nasal concha, and hyoid.	FMA:7477|NCIT:C32881|UMLS:C0502414|Wikipedia:Irregular_bone|SCTID:421560006	hp.json	os irregulare|os irregulare|os irregulare	http://purl.obolibrary.org/obo/UBERON_0008001		
HP:0011835	biolink:PhenotypicFeature	Absent scaphoid	Congenital absence of the scaphoid..	UMLS:C1847189	hp.json	Missing scaphoid bone|Absent scaphoid bone	http://purl.obolibrary.org/obo/HP_0011835		
HP:0011836	biolink:PhenotypicFeature	Delayed talus ossification	Delayed maturation and calcification of the talus.	UMLS:C4023168	hp.json		http://purl.obolibrary.org/obo/HP_0011836		
HP:0011837	biolink:PhenotypicFeature	Partial IgA deficiency	Detectable but decreased IgA levels that are more than 2 standard deviations below normal age-adjusted means.	UMLS:C4023167	hp.json		http://purl.obolibrary.org/obo/HP_0011837		
HP:0011838	biolink:PhenotypicFeature	Sclerodactyly	Localized thickening and tightness of the skin of the fingers or toes.	UMLS:C0150988|SNOMEDCT_US:201051000|SNOMEDCT_US:298285004|ICD-10:L94.3	hp.json		http://purl.obolibrary.org/obo/HP_0011838		
HP:0011839	biolink:PhenotypicFeature	Abnormal T cell count	A deviation from the normal count of T cells.	UMLS:C4021113	hp.json	Abnormality of T cell number|Abnormal number of T cells	http://purl.obolibrary.org/obo/HP_0011839		
GO:0097026	biolink:BiologicalProcess	dendritic cell dendrite assembly	Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.		hp.json	dendritic extension	http://purl.obolibrary.org/obo/GO_0097026		
CHEBI:26455	biolink:ChemicalSubstance	pyrroles	An azole that includes only one N atom and no other heteroatom as a part of the aromatic skeleton.		hp.json		http://purl.obolibrary.org/obo/CHEBI_26455		3_STAR
CHEBI:26456	biolink:ChemicalSubstance	pyrrolidine alkaloid			hp.json	pyrrolidine alkaloids	http://purl.obolibrary.org/obo/CHEBI_26456		3_STAR
HP:0011820	biolink:PhenotypicFeature	Membranous choanal atresia	Absence of the normal opening of the choana (the posterior nasal aperture) as a result of an obstructing choanal membrane that may be thin and strandlike or thick and pluglike.	UMLS:C4023174	hp.json		http://purl.obolibrary.org/obo/HP_0011820		
UBERON:0011642	biolink:AnatomicalEntity	oral epithelium from ectoderm	An epithelium that develops_from a ectoderm and is part of a oral epithelium.	EHDAA2:0004137	hp.json		http://purl.obolibrary.org/obo/UBERON_0011642		
UBERON:0011641	biolink:AnatomicalEntity	odontogenic mesenchyme of molar	An odontogenic papilla that is part of a molar tooth [Automatically generated definition].	MA:0003230|EMAPA:32881	hp.json	molar mesenchyme|odontogenic mesenchyme of molar tooth	http://purl.obolibrary.org/obo/UBERON_0011641		
HP:0011829	biolink:PhenotypicFeature	Narrow philtrum	Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations below the mean. Alternatively, an apparently decreased distance between the ridges of the philtrum.	UMLS:C4021115	hp.json	Decreased horizontal dimension of philtrum|Decreased breadth of philtrum|Thin philtrum|Decreased transverse dimension of philtrum|Philtrum, Narrow|Decreased width of philtrum	http://purl.obolibrary.org/obo/HP_0011829		hposlim_core
HP:0011821	biolink:PhenotypicFeature	Abnormal facial skeleton morphology	An abnormality of one or more of the set of bones that make up the facial skeleton.	SNOMEDCT_US:433096001|UMLS:C2315229	hp.json	Anomaly of facial bones|Anomaly of facial skeleton|Malformation of facial skeleton|Deformity of facial skeleton|Malformation of facial bones|Deformity of the facial bones|Abnormality of facial skeleton|Abnormality of facial bones	http://purl.obolibrary.org/obo/HP_0011821		
HP:0011822	biolink:PhenotypicFeature	Broad chin	Increased width of the midpoint of the mandible (mental protuberance) and overlying soft tissue.	UMLS:C4023172	hp.json	Increased width of chin|Increased width of menton region|Broad chin|Wide chin	http://purl.obolibrary.org/obo/HP_0011822		hposlim_core
HP:0011823	biolink:PhenotypicFeature	Chin with horizontal crease	Horizontal crease or fold situated below the vermilion border of the lower lip and above the fatty pad of the chin, with the face at rest.	UMLS:C4023171	hp.json	Chin with horizontal sulcus|Chin with horizontal furrow|Horizontal menton crease|Chin with horizontal crease|Horizontal chin skin cleft|Chin with horizontal groove	http://purl.obolibrary.org/obo/HP_0011823		
HP:0011824	biolink:PhenotypicFeature	Chin with H-shaped crease	H-shaped crease in the fat pad of the chin.	UMLS:C1860309	hp.json	H-shaped dimple of the chin|Chin, H-Shaped Crease|Chin, H-shaped groove|Chin with H-shaped crease	http://purl.obolibrary.org/obo/HP_0011824		
GO:0097028	biolink:BiologicalProcess	dendritic cell differentiation	The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.		hp.json		http://purl.obolibrary.org/obo/GO_0097028		
HP:0011825	biolink:PhenotypicFeature	Tented philtrum	Prominence of a triangular soft tissue area of the philtrum with the apex to the columella.	UMLS:C4021119	hp.json	Philtrum, Tented	http://purl.obolibrary.org/obo/HP_0011825		hposlim_core
HP:0011826	biolink:PhenotypicFeature	Philtrum with midline raphe	Narrow ridge in the midline of the philtral groove.	UMLS:C4021118	hp.json	Philtrum with midline ridge|Philtrum, midline raphe|Philtrum with central raphe	http://purl.obolibrary.org/obo/HP_0011826		hposlim_core
HP:0011827	biolink:PhenotypicFeature	Malaligned philtral ridges	Absence of the usual parallel position of philtral ridges.	UMLS:C4021117	hp.json	Asymmetric philtral columns|Asymmetric philtral ridges|Philtral Ridges, Malaligned|Malaligned philtral columns	http://purl.obolibrary.org/obo/HP_0011827		hposlim_core
HP:0011828	biolink:PhenotypicFeature	Midline sinus of philtrum	Pit in the midline of the philtral groove.	UMLS:C4021116	hp.json	Central sinus of philtrum|Philtrum, Midline Sinus	http://purl.obolibrary.org/obo/HP_0011828		hposlim_core
GO:0000041	biolink:BiologicalProcess	transition metal ion transport	The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.		hp.json	transition metal transport	http://purl.obolibrary.org/obo/GO_0000041		
CHEBI:167114	biolink:ChemicalSubstance	2-hydroxydicarboxylate(2-)	Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group. Major species at pH 7.3.		hp.json	a 2-hydroxydicarboxylate	http://purl.obolibrary.org/obo/CHEBI_167114		2_STAR
GO:1905806	biolink:BiologicalProcess	regulation of synapse pruning	Any process that modulates the frequency, rate or extent of synapse pruning.		hp.json	regulation of synapse disassembly|regulation of synapse elimination|regulation of synapse clearance|regulation of synapse removal	http://purl.obolibrary.org/obo/GO_1905806		goslim_synapse
GO:1905807	biolink:BiologicalProcess	negative regulation of synapse pruning	Any process that stops, prevents or reduces the frequency, rate or extent of synapse pruning.		hp.json	regulation of synapse elimination|down-regulation of synapse disassembly|regulation of synapse disassembly|down regulation of synapse disassembly|downregulation of synapse disassembly|inhibition of synapse disassembly|regulation of synapse removal|regulation of synapse clearance	http://purl.obolibrary.org/obo/GO_1905807		
GO:1905808	biolink:BiologicalProcess	positive regulation of synapse pruning	Any process that activates or increases the frequency, rate or extent of synapse pruning.		hp.json	regulation of synapse elimination|upregulation of synapse disassembly|regulation of synapse disassembly|up-regulation of synapse disassembly|regulation of synapse clearance|regulation of synapse removal|up regulation of synapse disassembly|activation of synapse disassembly	http://purl.obolibrary.org/obo/GO_1905808		
GO:1905809	biolink:BiologicalProcess	negative regulation of synapse organization	Any process that stops, prevents or reduces the frequency, rate or extent of synapse organization.		hp.json	inhibition of synapse organization and biogenesis|inhibition of synapse organisation|downregulation of synapse morphogenesis|inhibition of synapse development|downregulation of synapse organization|downregulation of synapse development|down-regulation of synapse organisation|negative regulation of synapse organisation|negative regulation of synapse organization and biogenesis|down-regulation of synapse organization and biogenesis|inhibition of synapse morphogenesis|down regulation of synapse organization|inhibition of synapse organization|down regulation of synapse organization and biogenesis|down-regulation of synapse organization|down-regulation of synapse morphogenesis|negative regulation of synapse morphogenesis|down-regulation of synapse development|negative regulation of synapse development|downregulation of synapse organisation|downregulation of synapse organization and biogenesis|down regulation of synapse morphogenesis|down regulation of synapse development|down regulation of synapse organisation	http://purl.obolibrary.org/obo/GO_1905809		
GO:0051641	biolink:BiologicalProcess	cellular localization	A cellular localization process whereby a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a cell including the localization of substances or cellular entities to the cell membrane.		hp.json	intracellular localization|localization within cell|establishment and maintenance of cellular localization|establishment and maintenance of localization in cell or cell membrane|cellular localisation|single-organism cellular localization|single organism cellular localization	http://purl.obolibrary.org/obo/GO_0051641		goslim_pir
GO:0051647	biolink:BiologicalProcess	nucleus localization	Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell.		hp.json	nucleus localisation|cell nucleus localization|localization of nucleus|establishment and maintenance of nucleus localization	http://purl.obolibrary.org/obo/GO_0051647		
GO:0051648	biolink:BiologicalProcess	vesicle localization	Any process in which a vesicle or vesicles are transported to, and/or maintained in, a specific location.		hp.json	cytoplasmic vesicle localization|vesicle localisation|establishment and maintenance of vesicle localization	http://purl.obolibrary.org/obo/GO_0051648		
GO:0051645	biolink:BiologicalProcess	Golgi localization	Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell.		hp.json	Golgi localisation|Golgi apparatus localization|establishment and maintenance of Golgi localization|Golgi body localization	http://purl.obolibrary.org/obo/GO_0051645		
GO:0051649	biolink:BiologicalProcess	establishment of localization in cell	Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.		hp.json	establishment of localisation in cell|establishment of intracellular localization|positioning within cell|establishment of localization within cell|establishment of cellular localization	http://purl.obolibrary.org/obo/GO_0051649		
GO:0000052	biolink:BiologicalProcess	citrulline metabolic process	The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.		hp.json	citrulline metabolism	http://purl.obolibrary.org/obo/GO_0000052		
GO:0051640	biolink:BiologicalProcess	organelle localization	Any process in which an organelle is transported to, and/or maintained in, a specific location.		hp.json	establishment and maintenance of organelle localization|organelle localisation	http://purl.obolibrary.org/obo/GO_0051640		goslim_pir
GO:0002687	biolink:BiologicalProcess	positive regulation of leukocyte migration	Any process that activates or increases the frequency, rate, or extent of leukocyte migration.		hp.json	positive regulation of immune cell migration|positive regulation of leucocyte migration|up-regulation of leukocyte migration|up regulation of leukocyte migration|activation of leukocyte migration|stimulation of leukocyte migration|upregulation of leukocyte migration	http://purl.obolibrary.org/obo/GO_0002687		
GO:0002688	biolink:BiologicalProcess	regulation of leukocyte chemotaxis	Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.		hp.json	regulation of immune cell chemotaxis|regulation of leucocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0002688		
GO:0002689	biolink:BiologicalProcess	negative regulation of leukocyte chemotaxis	Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.		hp.json	negative regulation of immune cell chemotaxis|negative regulation of leucocyte chemotaxis|downregulation of leukocyte chemotaxis|down regulation of leukocyte chemotaxis|inhibition of leukocyte chemotaxis|down-regulation of leukocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0002689		
GO:0002683	biolink:BiologicalProcess	negative regulation of immune system process	Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.		hp.json	down-regulation of immune system process|down regulation of immune system process|downregulation of immune system process|inhibition of immune system process	http://purl.obolibrary.org/obo/GO_0002683		
GO:0002684	biolink:BiologicalProcess	positive regulation of immune system process	Any process that activates or increases the frequency, rate, or extent of an immune system process.		hp.json	activation of immune system process|stimulation of immune system process|upregulation of immune system process|up-regulation of immune system process|up regulation of immune system process	http://purl.obolibrary.org/obo/GO_0002684		
GO:0051656	biolink:BiologicalProcess	establishment of organelle localization	The directed movement of an organelle to a specific location.		hp.json	establishment of organelle localisation	http://purl.obolibrary.org/obo/GO_0051656		
GO:0002685	biolink:BiologicalProcess	regulation of leukocyte migration	Any process that modulates the frequency, rate, or extent of leukocyte migration.		hp.json	regulation of immune cell migration|regulation of leucocyte migration	http://purl.obolibrary.org/obo/GO_0002685		
GO:0002686	biolink:BiologicalProcess	negative regulation of leukocyte migration	Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.		hp.json	inhibition of leukocyte migration|downregulation of leukocyte migration|negative regulation of immune cell migration|negative regulation of leucocyte migration|down-regulation of leukocyte migration|down regulation of leukocyte migration	http://purl.obolibrary.org/obo/GO_0002686		
GO:0002682	biolink:BiologicalProcess	regulation of immune system process	Any process that modulates the frequency, rate, or extent of an immune system process.		hp.json		http://purl.obolibrary.org/obo/GO_0002682		
GO:1905821	biolink:BiologicalProcess	positive regulation of chromosome condensation	Any process that activates or increases the frequency, rate or extent of chromosome condensation.		hp.json	up regulation of eukaryotic chromosome condensation|upregulation of chromosome condensation|up-regulation of nuclear chromosome condensation|activation of eukaryotic chromosome condensation|up-regulation of eukaryotic chromosome condensation|up regulation of nuclear chromosome condensation|activation of nuclear chromosome condensation|positive regulation of nuclear chromosome condensation|up-regulation of chromosome condensation|upregulation of eukaryotic chromosome condensation|up regulation of chromosome condensation|upregulation of nuclear chromosome condensation|activation of chromosome condensation|positive regulation of eukaryotic chromosome condensation	http://purl.obolibrary.org/obo/GO_1905821		
CHEBI:7044	biolink:ChemicalSubstance	myoglobin		COMe:PRX000322|KEGG:C05782	hp.json	vertebrate myoglobin|Myoglobin	http://purl.obolibrary.org/obo/CHEBI_7044		3_STAR
GO:0051650	biolink:BiologicalProcess	establishment of vesicle localization	The directed movement of a vesicle to a specific location.		hp.json	establishment of vesicle localisation	http://purl.obolibrary.org/obo/GO_0051650		goslim_aspergillus
GO:0002698	biolink:BiologicalProcess	negative regulation of immune effector process	Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.		hp.json	down-regulation of immune effector process|down regulation of immune effector process|inhibition of immune effector process|downregulation of immune effector process	http://purl.obolibrary.org/obo/GO_0002698		
GO:0000035	biolink:MolecularActivity	acyl binding	Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.		hp.json	acyl-CoA or acyl binding	http://purl.obolibrary.org/obo/GO_0000035		
GO:0002699	biolink:BiologicalProcess	positive regulation of immune effector process	Any process that activates or increases the frequency, rate, or extent of an immune effector process.		hp.json	upregulation of immune effector process|up-regulation of immune effector process|up regulation of immune effector process|activation of immune effector process|stimulation of immune effector process	http://purl.obolibrary.org/obo/GO_0002699		
GO:0002694	biolink:BiologicalProcess	regulation of leukocyte activation	Any process that modulates the frequency, rate, or extent of leukocyte activation.		hp.json	regulation of leucocyte activation|regulation of immune cell activation	http://purl.obolibrary.org/obo/GO_0002694		
GO:0002695	biolink:BiologicalProcess	negative regulation of leukocyte activation	Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.		hp.json	down regulation of leukocyte activation|inhibition of leukocyte activation|down-regulation of leukocyte activation|negative regulation of leucocyte activation|negative regulation of immune cell activation|downregulation of leukocyte activation	http://purl.obolibrary.org/obo/GO_0002695		
GO:0002696	biolink:BiologicalProcess	positive regulation of leukocyte activation	Any process that activates or increases the frequency, rate, or extent of leukocyte activation.		hp.json	positive regulation of immune cell activation|positive regulation of leucocyte activation|upregulation of leukocyte activation|up regulation of leukocyte activation|stimulation of leukocyte activation|up-regulation of leukocyte activation|activation of leukocyte activation	http://purl.obolibrary.org/obo/GO_0002696		
GO:0051668	biolink:BiologicalProcess	localization within membrane	Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.		hp.json	positioning within membrane|localisation within membrane|localization to membrane|establishment and maintenance of localization in membrane|establishment and maintenance of position in membrane	http://purl.obolibrary.org/obo/GO_0051668		
GO:0002697	biolink:BiologicalProcess	regulation of immune effector process	Any process that modulates the frequency, rate, or extent of an immune effector process.		hp.json		http://purl.obolibrary.org/obo/GO_0002697		
GO:0002690	biolink:BiologicalProcess	positive regulation of leukocyte chemotaxis	Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.		hp.json	positive regulation of leucocyte chemotaxis|positive regulation of immune cell chemotaxis|upregulation of leukocyte chemotaxis|up regulation of leukocyte chemotaxis|stimulation of leukocyte chemotaxis|up-regulation of leukocyte chemotaxis|activation of leukocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0002690		
CHEBI:157750	biolink:ChemicalSubstance	heparan sulfate polyanion	A carbohydrate acid derivative anion that is a polyanionic form of heparan sulfate arising from global deprotonation of the carboxy and N-sulfo groups; major species at pH 7.3.		hp.json	heparan sulfate group	http://purl.obolibrary.org/obo/CHEBI_157750		2_STAR
GO:1905833	biolink:BiologicalProcess	negative regulation of microtubule nucleation	Any process that stops, prevents or reduces the frequency, rate or extent of microtubule nucleation.		hp.json	downregulation of microtubule nucleation|down regulation of microtubule nucleation|inhibition of microtubule nucleation|down-regulation of microtubule nucleation	http://purl.obolibrary.org/obo/GO_1905833		
PR:000050343	biolink:Protein	alkaline phosphatase (human)	A protein that is a translation product of any of the following alkaline phosphatase genes in human: ALPG (encoding the germinal form; GCAP), ALPP (encoding the placental form; PLAP), ALPI (encoding the intestinal form; IAP), and ALPL (encoding the tissue non-specific form; TNAP).		hp.json	fam:hAP	http://purl.obolibrary.org/obo/PR_000050343		
GO:0000002	biolink:BiologicalProcess	mitochondrial genome maintenance	The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.		hp.json		http://purl.obolibrary.org/obo/GO_0000002		
GO:0051674	biolink:BiologicalProcess	localization of cell	Any process in which a cell is transported to, and/or maintained in, a specific location.		hp.json	establishment and maintenance of localization of cell|establishment and maintenance of cell localization|localisation of cell|cell localization	http://purl.obolibrary.org/obo/GO_0051674		
OBO:MAXO_0000784	biolink:NamedThing	HCG measurement	A quantitative measurement of the amount of human chorionic gonadotropin present in urine or serum.		hp.json	human chorionic gonadotropin measurement	http://purl.obolibrary.org/obo/MAXO_0000784		
GO:0000003	biolink:BiologicalProcess	reproduction	The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms.	Wikipedia:Reproduction	hp.json	reproductive physiological process	http://purl.obolibrary.org/obo/GO_0000003		goslim_plant|goslim_pir|goslim_flybase_ribbon|goslim_chembl|goslim_generic|goslim_agr
GO:0061007	biolink:NamedThing	hepaticobiliary system process			hp.json		http://purl.obolibrary.org/obo/GO_0061007		
OBO:MAXO_0000787	biolink:NamedThing	blood chemistry measurement	The determination of the measured concentrations of chemical constituents of the blood by assay in a clinical laboratory.	NCIT:C47868	hp.json	blood chemistry test	http://purl.obolibrary.org/obo/MAXO_0000787		
OBO:MAXO_0000788	biolink:NamedThing	serum chemistry measurement	A quantitative measurement of a particular substance present in a sample of serum.	NCIT:C61014	hp.json		http://purl.obolibrary.org/obo/MAXO_0000788		
OBO:MAXO_0000785	biolink:NamedThing	serum HCG measurement	A quantitative measurement of the amount of human chorionic gonadotropin present in a sample of serum.	NCIT:C73495	hp.json	serum HCG pregnancy measurement|serum human chorionic gonadotropin measurement|blood HCG pregancy test	http://purl.obolibrary.org/obo/MAXO_0000785		
OBO:MAXO_0000786	biolink:NamedThing	urine HCG measurement	A quantitative measurement of the amount of human chorionic gonadotropin present in a sample of urine.		hp.json	urine human chorionic gonadotropin measurement|urine HCG pregancy test|urine HCG pregnancy measurement	http://purl.obolibrary.org/obo/MAXO_0000786		
OBO:MAXO_0000789	biolink:NamedThing	urine chemistry measurement	A quantitative measurement of a particular substance present in a sample of urine.	NCIT:C61044	hp.json		http://purl.obolibrary.org/obo/MAXO_0000789		
GO:0099612	biolink:BiologicalProcess	protein localization to axon	A process in which a protein is transported to or maintained in a location within an axon.		hp.json		http://purl.obolibrary.org/obo/GO_0099612		
GO:0002676	biolink:BiologicalProcess	regulation of chronic inflammatory response	Any process that modulates the frequency, rate, or extent of a chronic inflammatory response.		hp.json		http://purl.obolibrary.org/obo/GO_0002676		
GO:0002677	biolink:BiologicalProcess	negative regulation of chronic inflammatory response	Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.		hp.json	inhibition of chronic inflammatory response|downregulation of chronic inflammatory response|down-regulation of chronic inflammatory response|down regulation of chronic inflammatory response	http://purl.obolibrary.org/obo/GO_0002677		
GO:0000011	biolink:BiologicalProcess	vacuole inheritance	The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.		hp.json		http://purl.obolibrary.org/obo/GO_0000011		
GO:0002678	biolink:BiologicalProcess	positive regulation of chronic inflammatory response	Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.		hp.json	up-regulation of chronic inflammatory response|up regulation of chronic inflammatory response|activation of chronic inflammatory response|stimulation of chronic inflammatory response|upregulation of chronic inflammatory response	http://purl.obolibrary.org/obo/GO_0002678		
GO:0002679	biolink:BiologicalProcess	respiratory burst involved in defense response	A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.		hp.json		http://purl.obolibrary.org/obo/GO_0002679		
GO:0000016	biolink:MolecularActivity	lactase activity	Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.	Reactome:R-HSA-189062|EC:3.2.1.108|RHEA:10076|Reactome:R-HSA-5658001|MetaCyc:LACTASE-RXN	hp.json	lactose galactohydrolase activity	http://purl.obolibrary.org/obo/GO_0000016		
GO:0002673	biolink:BiologicalProcess	regulation of acute inflammatory response	Any process that modulates the frequency, rate, or extent of an acute inflammatory response.		hp.json		http://purl.obolibrary.org/obo/GO_0002673		
GO:0002674	biolink:BiologicalProcess	negative regulation of acute inflammatory response	Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.		hp.json	inhibition of acute inflammatory response|downregulation of acute inflammatory response|down-regulation of acute inflammatory response|down regulation of acute inflammatory response	http://purl.obolibrary.org/obo/GO_0002674		
GO:0002675	biolink:BiologicalProcess	positive regulation of acute inflammatory response	Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.		hp.json	up-regulation of acute inflammatory response|up regulation of acute inflammatory response|activation of acute inflammatory response|stimulation of acute inflammatory response|upregulation of acute inflammatory response	http://purl.obolibrary.org/obo/GO_0002675		
GO:0051683	biolink:BiologicalProcess	establishment of Golgi localization	The directed movement of the Golgi to a specific location.		hp.json	establishment of Golgi apparatus localization|establishment of Golgi body localization|establishment of Golgi localisation	http://purl.obolibrary.org/obo/GO_0051683		
OBO:MAXO_0000778	biolink:NamedThing	liver function testing	The quantitative measurement of liver enzymes in the blood, which is useful in assessing the functional state of a patient's liver. Liver function tests include the measurement of albumin, alanine transaminase, aspartate transaminase, alkaline phosphatase, bilirubin, and gamma glutamyl transferase.	NCIT:C74954	hp.json	liver function assessment|LFT	http://purl.obolibrary.org/obo/MAXO_0000778		
GO:1905871	biolink:BiologicalProcess	regulation of protein localization to cell leading edge	Any process that modulates the frequency, rate or extent of protein localization to cell leading edge.		hp.json	regulation of protein localisation in cell leading edge|regulation of protein localization in cell leading edge|regulation of protein localisation to cell leading edge	http://purl.obolibrary.org/obo/GO_1905871		
GO:0048048	biolink:BiologicalProcess	embryonic eye morphogenesis	The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0048048		
GO:1905872	biolink:BiologicalProcess	negative regulation of protein localization to cell leading edge	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge.		hp.json	inhibition of protein localization in cell leading edge|down-regulation of protein localisation in cell leading edge|downregulation of protein localization in cell leading edge|negative regulation of protein localisation in cell leading edge|inhibition of protein localisation to cell leading edge|downregulation of protein localisation to cell leading edge|down regulation of protein localisation in cell leading edge|down-regulation of protein localization to cell leading edge|inhibition of protein localisation in cell leading edge|down regulation of protein localization to cell leading edge|downregulation of protein localisation in cell leading edge|negative regulation of protein localization in cell leading edge|down-regulation of protein localization in cell leading edge|inhibition of protein localization to cell leading edge|downregulation of protein localization to cell leading edge|negative regulation of protein localisation to cell leading edge|down-regulation of protein localisation to cell leading edge|down regulation of protein localization in cell leading edge|down regulation of protein localisation to cell leading edge	http://purl.obolibrary.org/obo/GO_1905872		
GO:0061024	biolink:BiologicalProcess	membrane organization	A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.		hp.json	membrane organization and biogenesis|cellular membrane organisation|cellular membrane organization|membrane organisation|single-organism membrane organization	http://purl.obolibrary.org/obo/GO_0061024		goslim_generic|prokaryote_subset|goslim_pombe|goslim_pir|goslim_drosophila|goslim_chembl
GO:0061025	biolink:BiologicalProcess	membrane fusion	The membrane organization process that joins two lipid bilayers to form a single membrane.	Wikipedia:Lipid_bilayer_fusion	hp.json	cellular membrane fusion|single-organism membrane fusion	http://purl.obolibrary.org/obo/GO_0061025		goslim_yeast
OBO:MAXO_0000790	biolink:NamedThing	clinical breast examination	A systemic evaluation of the breast using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.	NCIT:C70552	hp.json	examination of breast|clinical breast exam|breast examination|breast exam|physical examination of breast	http://purl.obolibrary.org/obo/MAXO_0000790		
OBO:MAXO_0000791	biolink:NamedThing	breast self-examination	Procedure where the individual examines their own breasts for lumps and other changes.	NCIT:C70551	hp.json	breast self-surveillance|breast self-exam	http://purl.obolibrary.org/obo/MAXO_0000791		
OBO:MAXO_0000794	biolink:NamedThing	fundal height measurement	A  measurement generally defined as the distance in centimeters from the pubic bone to the top of the uterus to determine fetal growth.	NCIT:C154876	hp.json		http://purl.obolibrary.org/obo/MAXO_0000794		
OBO:MAXO_0000795	biolink:NamedThing	uterine size measurement	Determination of the uterine size by ultrasound or other measurement.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000795		
OBO:MAXO_0000792	biolink:NamedThing	abdominal examination	A systemic evaluation of the abdomen using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.	NCIT:C167415	hp.json	physical examination of abdomen|abdomen exam|examination of the abdomen|examination of abdomen	http://purl.obolibrary.org/obo/MAXO_0000792		
OBO:MAXO_0000793	biolink:NamedThing	pelvic examination	A systemic evaluation of the pelvic region of trunk using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.	NCIT:C38104	hp.json	pelvis examination|examination of pelvic region of trunk|pelvic exam|examination of pelvis|physical examination of pelvic region of trunk|pelvic region of trunk exam	http://purl.obolibrary.org/obo/MAXO_0000793		
GO:1905880	biolink:BiologicalProcess	negative regulation of oogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of oogenesis.		hp.json	down regulation of ovum development|down-regulation of oogenesis|inhibition of ovum development|down-regulation of ovum development|negative regulation of ovum development|down regulation of oogenesis|inhibition of oogenesis|downregulation of oogenesis|downregulation of ovum development	http://purl.obolibrary.org/obo/GO_1905880		
GO:1905881	biolink:BiologicalProcess	positive regulation of oogenesis	Any process that activates or increases the frequency, rate or extent of oogenesis.		hp.json	upregulation of oogenesis|upregulation of ovum development|positive regulation of ovum development|up-regulation of oogenesis|up regulation of ovum development|up regulation of oogenesis|up-regulation of ovum development|activation of oogenesis|activation of ovum development	http://purl.obolibrary.org/obo/GO_1905881		
GO:1905873	biolink:BiologicalProcess	positive regulation of protein localization to cell leading edge	Any process that activates or increases the frequency, rate or extent of protein localization to cell leading edge.		hp.json	activation of protein localization to cell leading edge|up-regulation of protein localization in cell leading edge|upregulation of protein localisation in cell leading edge|up-regulation of protein localisation to cell leading edge|up regulation of protein localization in cell leading edge|upregulation of protein localization to cell leading edge|up regulation of protein localisation to cell leading edge|positive regulation of protein localization in cell leading edge|activation of protein localization in cell leading edge|positive regulation of protein localisation to cell leading edge|activation of protein localisation to cell leading edge|up-regulation of protein localisation in cell leading edge|upregulation of protein localization in cell leading edge|up regulation of protein localisation in cell leading edge|up-regulation of protein localization to cell leading edge|upregulation of protein localisation to cell leading edge|positive regulation of protein localisation in cell leading edge|activation of protein localisation in cell leading edge|up regulation of protein localization to cell leading edge	http://purl.obolibrary.org/obo/GO_1905873		
GO:1905879	biolink:BiologicalProcess	regulation of oogenesis	Any process that modulates the frequency, rate or extent of oogenesis.		hp.json	regulation of ovum development	http://purl.obolibrary.org/obo/GO_1905879		
OBO:MAXO_0000798	biolink:NamedThing	internal fetal heart rate monitoring	A technique that utilizes a wire attached to the fetal scalp to monitor fetal heart rate. The wire detects fetal cardiac electrical activity to determine the baseline fetal heart rate and variability.	NCIT:C114083	hp.json	fetal scalp electrode monitoring|FSE	http://purl.obolibrary.org/obo/MAXO_0000798		
OBO:MAXO_0000796	biolink:NamedThing	fetal heart rate monitoring	The act of observing and recording the fetal heart rate for determining the baseline values or other abnormal findings.	NCIT:C92929	hp.json	fetal heart rate measurement|fetal heart monitoring	http://purl.obolibrary.org/obo/MAXO_0000796		
OBO:MAXO_0000797	biolink:NamedThing	obsolete fetal Doppler monitoring	A technique that utilizes a Doppler transducer to monitor fetal heart rate. The transducer is placed on the maternal abdomen and detects fetal cardiac motion using ultrasound.	NCIT:C114081	hp.json	external fetal heart rate monitoring|EFM|fetal Doppler ultrasound monitoring	http://purl.obolibrary.org/obo/MAXO_0000797		
HP:0033161	biolink:PhenotypicFeature	Abnormal urinary purine level	Any deviation from the normal amount of a purine compound in the urine. Purines are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring. Two of the four deoxyribonucleotides (deoxyadenosine and deoxyguanosine) and two of the four ribonucleotides (adenosine, or AMP, and guanosine, or GMP) are purines.		hp.json		http://purl.obolibrary.org/obo/HP_0033161		
HP:0033160	biolink:PhenotypicFeature	Decreased urinary guanosine level	Decreased level of guanosine in urine. Guanosine is a purine nucleoside in which guanine is attached to ribofuranose via a beta-N(9)-glycosidic bond.		hp.json		http://purl.obolibrary.org/obo/HP_0033160		
HP:0033163	biolink:PhenotypicFeature	Small intestinal bacterial overgrowth	An increased number and/or abnormal type of bacteria in the small bowel. Small intestinal bacterial overgrowth has been defined as the presence of greater than one hundred thousand bacteria (i.e. colony-forming units, CFU) per mL of proximal jejunal aspiration. The normal value is ten thousand or few CFU/ml.		hp.json		http://purl.obolibrary.org/obo/HP_0033163		
HP:0033162	biolink:PhenotypicFeature	Abnormal urinary pyrimidine level	Any deviation from the normal amount of a pyrimidine compound in the urine. Pyrimidines and pyrimidine derivatives are compounds containing a pyrimidne ring, which is a six-member aromatic heterocycle which consists of two nitrogen atoms (at positions 1 and 3) and four carbon atoms. The nucleotides cytosine, thymine and uracil are pyrimidines.		hp.json		http://purl.obolibrary.org/obo/HP_0033162		
HP:0033169	biolink:PhenotypicFeature	Reduced total lung capacity	Abnormally reduced volume of air in the lungs upon the maximum effort of inspiration.		hp.json	Reduced TLC	http://purl.obolibrary.org/obo/HP_0033169		
HP:0033168	biolink:PhenotypicFeature	Reduced mevalonate kinase activity	Abnormally reduced activity of mevalonate kinase, ,which is a key enzyme in the mevalonate biosynthetic pathway that leads to the synthesis of both cholesterol and nonsterol isoprenoids.		hp.json		http://purl.obolibrary.org/obo/HP_0033168		
HP:0033165	biolink:PhenotypicFeature	Necrotizing enterocolitis	Inflammation of the intestine leading to bacterial invasion causing cellular damage and death which causes necrosis of the colon and intestine.		hp.json		http://purl.obolibrary.org/obo/HP_0033165		
HP:0033164	biolink:PhenotypicFeature	Focal active colitis	Focal active colitis (FAC) is characterized by focal crypt damage caused by neutrophils. FAC is characterized by an inflammatory infiltrate consisting of intraepithelial neutrophils and/or neutrophils invading the lumen of the criptae, with no other microscopic alteration of the colonic mucosa and, in particular, without the presence of signs of chronic inflammation.		hp.json		http://purl.obolibrary.org/obo/HP_0033164		
HP:0033167	biolink:PhenotypicFeature	Neutrophilic urticarial dermatosis	A neutrophilic interstitial, perivascular and/or perieccrine infiltrate with leukocytoclasia. Notably, leukocytoclastic vasculitis is not present.		hp.json		http://purl.obolibrary.org/obo/HP_0033167		
HP:0033166	biolink:PhenotypicFeature	Recurrent viral upper respiratory tract infections	An increased susceptibility to viral upper respiratory tract infections as manifested by a history of recurrent viral upper respiratory tract infections (otitis, sinusitis, pharyngitis, tonsillitis).		hp.json		http://purl.obolibrary.org/obo/HP_0033166		
PR:000003964	biolink:Protein	intestinal alkaline phosphatase	A protein that is a translation product of the human ALPI gene or a 1:1 ortholog thereof.		hp.json	ALPI|IAP	http://purl.obolibrary.org/obo/PR_000003964		
PR:000003968	biolink:Protein	alkaline phosphatase, tissue-nonspecific isozyme	A protein that is a translation product of the human ALPL gene or a 1:1 ortholog thereof.		hp.json	phosphoamidase|Akp-2|phosphocreatine phosphatase|TNSALP|alkaline phosphatase liver/bone/kidney isozyme|ALPL|AP-TNAP|alkaline phosphatase 2|Akp2	http://purl.obolibrary.org/obo/PR_000003968		
GO:0036072	biolink:BiologicalProcess	direct ossification	The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.		hp.json		http://purl.obolibrary.org/obo/GO_0036072		
GO:0036075	biolink:BiologicalProcess	replacement ossification	Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation.		hp.json	indirect ossification	http://purl.obolibrary.org/obo/GO_0036075		
PR:000001308	biolink:Protein	CD48 molecule	A protein that is a translation product of the human CD48 gene or a 1:1 ortholog thereof.	PANTHER:PTHR12080:SF3|PIRSF:PIRSF001973	hp.json	CD48 antigen|SLAMF2|leukocyte antigen MEM-102|BCM1 surface antigen|BLAST1|MRC OX-45 surface antigen|signaling lymphocytic activation molecule 2|HM48-1|SLAM family member 2|BLAST-1|sgp-60|BCM1|B-lymphocyte activation marker BLAST-1|TCT.1|CD48|Bcm-1	http://purl.obolibrary.org/obo/PR_000001308		
HP:0008198	biolink:PhenotypicFeature	Congenital hypoparathyroidism	Deficiency of parathyroid hormone with congenital onset.	UMLS:C1455734	hp.json	Neonatal hypoparathyroidism	http://purl.obolibrary.org/obo/HP_0008198		
HP:0008197	biolink:PhenotypicFeature	Absence of pubertal development		UMLS:C1846228	hp.json		http://purl.obolibrary.org/obo/HP_0008197		
CHEBI:77974	biolink:ChemicalSubstance	food packaging gas	A food additive that is a (generally inert) gas which is used to envelop foodstuffs during packing and so protect them from unwanted chemical reactions such as food spoilage or oxidation during subsequent transport and storage. The term includes propellant gases, used to expel foods from a container.	Wikipedia:Packaging_gas	hp.json	food packaging gases	http://purl.obolibrary.org/obo/CHEBI_77974		3_STAR
PR:000003969	biolink:Protein	alkaline phosphatase, placental type	A protein that is a translation product of the human ALPP gene or a 1:1 ortholog thereof.		hp.json	PLAP|PLAP-1|alkaline phosphatase Regan isozyme|ALPP|placental alkaline phosphatase 1	http://purl.obolibrary.org/obo/PR_000003969		
OBO:MAXO_0000745	biolink:NamedThing	cytogenetic analysis	Techniques for analysis of chromosomal and subchromosomal properties and structures, such as those to diagnose, classify, screen for, or manage genetic diseases and abnormalities.	NCIT:C18280	hp.json	cytogenetic study|cytogenetic testing	http://purl.obolibrary.org/obo/MAXO_0000745		
OBO:MAXO_0000746	biolink:NamedThing	chromosomal breakage analysis	A test to detect chromosomal breakage or aberrations (breaks, gaps, rearrangements, radials, exchanges, endoreduplications) in peripheral blood cells after culture with a T-cell mitogen and a DNA clastogenic (cross-linking) agent, such as diepoxybutane (DEB) or mitomycin C (MMC).		hp.json	DEB/MMC testing|induced chormosomal breakage testing|Chromosome Breakage Analysis (DEB/MMC)|chromosomal breakage testing	http://purl.obolibrary.org/obo/MAXO_0000746		
HP:0033172	biolink:PhenotypicFeature	Increased triceps skinfold thickness	Increased thickness of the triceps skinfold, which is measured halfway down the back of the upper arm is increased.		hp.json		http://purl.obolibrary.org/obo/HP_0033172		
HP:0033171	biolink:PhenotypicFeature	Abnormal triceps skinfold thickness	Any deviation from the normal range of the thickness of the tricpes skinfold, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers.		hp.json		http://purl.obolibrary.org/obo/HP_0033171		
HP:0033174	biolink:PhenotypicFeature	Bloody bronchoalveolar lavage fluid	Return of lavage fluid characteristically has a bloody apperance in pulmonary alveolar hemorrhage. This is due to admixture of blood, which typically increases with each consecutive lavage portion. Microscopically erythrocytes can be seen. After 24 to 48 h macrophages contain phagocytosed erythrocytes, indicating previous bleeding.		hp.json		http://purl.obolibrary.org/obo/HP_0033174		
CHEBI:75325	biolink:ChemicalSubstance	cathartic	Any substance that accelerates defecation. Compare with laxatives, which are substances that ease defecation (usually by softening faeces). A substance can be both a laxative and a cathartic.	Wikipedia:Cathartic	hp.json	cathartics	http://purl.obolibrary.org/obo/CHEBI_75325		3_STAR
HP:0033173	biolink:PhenotypicFeature	Milky appearance of bronchoalveolar lavage fluid	Return of lavage fluid with a milky apperance due to the accumulation of a mixture of pulmonary surfactant, which is a lipoprotein complex, in the alveolar space.		hp.json		http://purl.obolibrary.org/obo/HP_0033173		
HP:0033170	biolink:PhenotypicFeature	Abnormal skinfold thickness measurement	Any deviation from the normal range of a skinfold thickness, which quantifies the amount of subcutaneous fat when the skin is pinched by specialized calipers.		hp.json		http://purl.obolibrary.org/obo/HP_0033170		
HP:0033179	biolink:PhenotypicFeature	Elevated circulating aconitic acid concentration	An increased concentration of aconitic acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033179		
HP:0033176	biolink:PhenotypicFeature	Submandibular lymph node enlargement	Increased size of the lymph nodes that are located beneath the mandible (lower jaw).		hp.json	Submandibular lymphadenopathy	http://purl.obolibrary.org/obo/HP_0033176		
HP:0033175	biolink:PhenotypicFeature	Elevated circulating 5-oxoproline concentration	Concentration of L-pyroglutamic acid in the blood is above the normal range.		hp.json	Elevated circulating L-pyroglutamic acid concentration	http://purl.obolibrary.org/obo/HP_0033175		
HP:0033178	biolink:PhenotypicFeature	Increased circulating interleukin 8 concentration	An increased concentration of interleukin-8 in the circulation.		hp.json	Increased serum interleukin-8|Increased serum IL-8|Increased serum interleukin 8	http://purl.obolibrary.org/obo/HP_0033178		
HP:0033177	biolink:PhenotypicFeature	Elevated circulating suberic acid concentration	An increased concentration of suberic acid in the blood circulation. Suberic acid is an alpha,omega-dicarboxylic acid that is the 1,6-dicarboxy derivative of hexane.		hp.json		http://purl.obolibrary.org/obo/HP_0033177		
PR:000003970	biolink:Protein	alkaline phosphatase, germ cell type	A protein that is a translation product of the human ALPG gene or a 1:1 ortholog thereof.		hp.json	placental alkaline phosphatase-like|GCAP|PLAP-like|ALP-1|germ cell alkaline phosphatase|ALPPL|ALPPL2|ALPG|alkaline phosphatase, placental-like|alkaline phosphatase Nagao isozyme	http://purl.obolibrary.org/obo/PR_000003970		
OBO:MAXO_0000732	biolink:NamedThing	occupational therapist evaluation	An initial evaluation or assessment by a health professional trained to help people who are ill or disabled learn to manage their daily activities.		hp.json	evaluation by occupational therapist|OT eval|OT evaluation|occupational therapist management|treatment by OT|occupational therapist assessment|treatment by occupational therapist|OT consult|assessment by occupational therapist|OT treatment|occupational therapist consultation|OT assessment|managed by occupational therapist|occupational therapist treatment	http://purl.obolibrary.org/obo/MAXO_0000732		
OBO:MAXO_0000733	biolink:NamedThing	speech-language pathologist evaluation	An initial assessment by a professional who works to prevent, assess, diagnose, and treat speech, language, social communication, congnitive-communication, and swallowing disorders.		hp.json	speech therapist assessment|evaluation by speech and language therapist|speech-language pathologist examination|speech and language therapist evaluation|consult with speech therapist|speech therapist evaluation|speech-language pathologist assessment|speech therapist consultation|speech/language therapist evaluation|speech and language pathologist evaluation|assessment with speech therapist|speech/language pathologist evaluation	http://purl.obolibrary.org/obo/MAXO_0000733		
OBO:MAXO_0000731	biolink:NamedThing	allied health professional evaluation	A procedure where a allied health care provider who was not previously involved in a patient's treatment, reviews a patient's medical history, examines the patient, and makes recommendations as to care and treatment. This is care provided by health care practitioners who are distinct providers from dentistry, nursing, medicine, and pharmacy health care professionals.		hp.json	allied health practitioner consultation|allied health clnicians support|assessment by allied health professional|consulationat with allied health professional|support by allied health clinicians|consultation with allied health practitioner|allied health professional consultation|allied health practitioner evaluation|evaluation by allied health professional|evaluation managed by allied health professional	http://purl.obolibrary.org/obo/MAXO_0000731		
GO:0036065	biolink:BiologicalProcess	fucosylation	The covalent attachment of a fucosyl group to an acceptor molecule.		hp.json		http://purl.obolibrary.org/obo/GO_0036065		
GO:0036066	biolink:BiologicalProcess	protein O-linked fucosylation	The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage.		hp.json		http://purl.obolibrary.org/obo/GO_0036066		
OBO:MAXO_0000734	biolink:NamedThing	audiologist evaluation	A first assessment by a trained non-medical health professional who specializes in the identification, testing, habilitation and rehabilitation of hearing loss and other auditory and balance disorders. Particularly, an audiologist may be involved in diagnostic and screening procedures to determine hearing deficits, as well as in assessment of amplification devices and instruction in their care, training in speechreading, and may serve as consultant to government and industry on issues concerning environmental, noise-induced hearing loss.	NCIT:C51804	hp.json	audiologic evaluation|audiology evaluation|assessment by audiologist|audilogic assessment|audiology examination|treatment by audiologist|evaluation by audiologist	http://purl.obolibrary.org/obo/MAXO_0000734		
HP:0033183	biolink:PhenotypicFeature	Bilobed right lung	A developmental defect of pulmonary lobation characterized by the presence of only two lobes of the right lung.		hp.json		http://purl.obolibrary.org/obo/HP_0033183		
HP:0008182	biolink:PhenotypicFeature	Adrenocortical hypoplasia		UMLS:C4024719	hp.json	Small adrenal cortex	http://purl.obolibrary.org/obo/HP_0008182		
HP:0033182	biolink:PhenotypicFeature	Increased circulating cathepsin D level	An increase in concentration of cathepsin D in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033182		
HP:0008185	biolink:PhenotypicFeature	Precocious puberty in males	The onset of puberty before the age of 9 years in boys.	UMLS:C1859979	hp.json	Male precocious puberty|Early onset of puberty in males	http://purl.obolibrary.org/obo/HP_0008185		
HP:0033185	biolink:PhenotypicFeature	Triggered by EBV infection	Applies to a sign or symptom that is provoked or brought about by infection by the Epstein-Barr virus.		hp.json	Triggered by Epstein Barr virus infection	http://purl.obolibrary.org/obo/HP_0033185		
HP:0033184	biolink:PhenotypicFeature	Triggered by infection			hp.json		http://purl.obolibrary.org/obo/HP_0033184		
HP:0033181	biolink:PhenotypicFeature	Spinal epidural abscess	Spinal epidural abscess (SEA) is caused by a suppurative infection in the epidural space. The mass effect ofthe abscess can compress and reduce blood flow to the spinal cord, conus medullaris, or cauda equina. Left untreated, the infection can lead to sensory loss,muscle weakness, visceral dysfunction, sepsis, and even death. Early diagnosis is essential to limit mor-bidity and neurologic injury. The classic triad of fever, axial pain, and neurological deficit occurs in as few as 13 percent of patients, highlighting the diagnosticchallenge associated with SEA.		hp.json	A severe pyogenic infection of the epidural space	http://purl.obolibrary.org/obo/HP_0033181		
HP:0008181	biolink:PhenotypicFeature	Abetalipoproteinemia	An absence of low-density lipoprotein cholesterol in the blood.	UMLS:C0000744|MSH:D000012|SNOMEDCT_US:190787008	hp.json		http://purl.obolibrary.org/obo/HP_0008181		
HP:0008180	biolink:PhenotypicFeature	Mildly elevated creatine kinase		UMLS:C1850309	hp.json	Mildly elevated CPK|Mildly elevated serum phospho-CK|Mildly increased creatine kinase|Mildly elevated serum CK|Moderately elevated serum CK|Mildly elevated creatine phosphokinase|Moderately elevated serum CPK|Mildly elevated serum CPK|Moderately increased serum creatine kinase|Mildly increased serum creatine kinase	http://purl.obolibrary.org/obo/HP_0008180		
HP:0033180	biolink:PhenotypicFeature	Torsion of appendix of testis	The appendix testis or hydatid of Morgagni, is a vestigial remnant of the Müllerian duct located on the superior pole of the testicle between the testis and epididymis. Although this appendage has no vital function, it is present in 50% of males. Torsion of twisting of this vestigial remnant can be incredibly painful, but usually requires no medical intervention.		hp.json	Twisted vestigial remnant of the Muellerian duct	http://purl.obolibrary.org/obo/HP_0033180		
HP:0033187	biolink:PhenotypicFeature	Hyperimidodipeptiduria	Elevated levels of proline-containing dipeptides in urine.		hp.json	Imidodipeptiduria	http://purl.obolibrary.org/obo/HP_0033187		
HP:0033186	biolink:PhenotypicFeature	Misalignment of the pulmonary veins	The term is commonly used to describe a putative abnormal location of pulmonary vein branches adjacent to pulmonary arteries within the same adventitial sheath. However, evidence has been provided that the vessels in question are not pulmonary veins, however represent dilated bronchial veins.		hp.json		http://purl.obolibrary.org/obo/HP_0033186		
HP:0033189	biolink:PhenotypicFeature	Radiculomegaly	Tooth root length more than 2 SD above mean, or subjectively apparently increased tooth root length.		hp.json	Rhizomegaly|Root gigantism|Long dental root	http://purl.obolibrary.org/obo/HP_0033189		
CHEBI:63353	biolink:ChemicalSubstance	disaccharide derivative	A carbohydrate derivative that is formally obtained from a disaccharide.		hp.json	disaccharide derivatives	http://purl.obolibrary.org/obo/CHEBI_63353		3_STAR
HP:0033188	biolink:PhenotypicFeature	Cystic acne	A severe type of acne characterized by the formation of cysts enclosing a mixture of keratin and sebum.		hp.json		http://purl.obolibrary.org/obo/HP_0033188		
HP:0008179	biolink:PhenotypicFeature	Decreased Arden ratio of electrooculogram	An abnormal reduction in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record.	UMLS:C4024720	hp.json	Decreased Arden ratio of EOG	http://purl.obolibrary.org/obo/HP_0008179		
HP:0008176	biolink:PhenotypicFeature	Neonatal unconjugated hyperbilirubinemia		SNOMEDCT_US:281611002|UMLS:C0559506	hp.json		http://purl.obolibrary.org/obo/HP_0008176		
HP:0008178	biolink:PhenotypicFeature	Abnormal cartilage matrix		UMLS:C4024721	hp.json		http://purl.obolibrary.org/obo/HP_0008178		
HP:0008194	biolink:PhenotypicFeature	Multiple pancreatic beta-cell adenomas	The presence of multiple pancreatic islet cell adenomas.	UMLS:C4024718	hp.json		http://purl.obolibrary.org/obo/HP_0008194		
HP:0033194	biolink:PhenotypicFeature	Perioral erythema	Erythema (Redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin) localized to the region surrounding the mouth.		hp.json		http://purl.obolibrary.org/obo/HP_0033194		
HP:0008193	biolink:PhenotypicFeature	Primary gonadal insufficiency		UMLS:C1859014	hp.json		http://purl.obolibrary.org/obo/HP_0008193		
HP:0033193	biolink:PhenotypicFeature	Ballooning hepatocyte degeneration	Swelling of the hepatocyte, rounding of its contour, and alteration of the cytoplasm, which takes on a reticulated, rarified, or flocculant quality. The cytoplasm of the ballooned hepatocytes often contains clumps of eosinophilic ropey material known as Mallory-Denk bodies (MDBs) or Mallory hyaline, which is composed of hyperphosphorylated misfolded intermediate filaments, ubiquitin, and ubiquitin-binding protein P62.		hp.json	Ballooning degeneration of hepatocytes	http://purl.obolibrary.org/obo/HP_0033193		
HP:0033196	biolink:PhenotypicFeature	Portal inflammation	Infiltration of portal fields by inflammatory cells.		hp.json	Hepatic portal inflammation	http://purl.obolibrary.org/obo/HP_0033196		
HP:0033195	biolink:PhenotypicFeature	Perianal erythema	Erythema (Redness of the skin caused by hyperemia of the capillaries in the lower layers of the skin) localized to the region surrounding the anus.		hp.json		http://purl.obolibrary.org/obo/HP_0033195		
HP:0033190	biolink:PhenotypicFeature	Hypertrichotic hyperpigmented patch	A large nonpalpable spot of the skin over 1 cm in dimension with increased pigmentation and increased hair growth.		hp.json	Cutaneous hyperpigmentation with overlying hypertrichosis	http://purl.obolibrary.org/obo/HP_0033190		
OBO:MAXO_0000751	biolink:NamedThing	clinical surveilance	The systematic collection, analysis, and interpretation of health data on an ongoing basis.	NCIT:C15719	hp.json		http://purl.obolibrary.org/obo/MAXO_0000751		
HP:0033192	biolink:PhenotypicFeature	Decreased circulating selenium concentration	An abnormally reduced concentration of selenium in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033192		
HP:0008191	biolink:PhenotypicFeature	Thyroid agenesis	The congenital absence of the thyroid gland.	UMLS:C0749420|UMLS:C4020805|MSH:D050033	hp.json	Athyroidal hypothyroidism	http://purl.obolibrary.org/obo/HP_0008191		
HP:0033191	biolink:PhenotypicFeature	Increased circulating selenium concentration	An increased concentration of selenium in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033191		
CHEBI:63367	biolink:ChemicalSubstance	monosaccharide derivative	A carbohydrate derivative that is formally obtained from a monosaccharide.		hp.json	monosaccharide derivatives	http://purl.obolibrary.org/obo/CHEBI_63367		3_STAR
HP:0033198	biolink:PhenotypicFeature	Triggered by viral infection	Applies to a sign or symptom that is provoked or brought about by infection by a virus.		hp.json		http://purl.obolibrary.org/obo/HP_0033198		
HP:0033197	biolink:PhenotypicFeature	Hepatic lobular inflammation	Infiltration of inflammatory cells in lobules of the liver. A focus of lobular inflammation can be defined as two or more inflammatory cells (neutrophils, lymphocytes and other mononuclear cells, eosinophils and microgranulomas) within the lobule present within the sinusoids or surrounding injured hepatocytes (ballooned or apoptotic hepatocytes).		hp.json		http://purl.obolibrary.org/obo/HP_0033197		
HP:0033199	biolink:PhenotypicFeature	Increased circulating interleukin 10 concentration	An elevation of the concentration of interleukin 10 in the blood circulation.		hp.json	Increased serum interleukin 10	http://purl.obolibrary.org/obo/HP_0033199		
OBO:MAXO_0000754	biolink:NamedThing	cellularity measurement	The determination of the amount of degree, quality or condition of cells present in a sample.	NCIT:C111153	hp.json	cellularity indexing|cellularity grade measurement	http://purl.obolibrary.org/obo/MAXO_0000754		
OBO:MAXO_0000755	biolink:NamedThing	liquid biopsy	The sampling and analysis of non-solid biological tissue often through rapid and non-invasive methods, which allows the assessment in real-time of the evolving landscape of cancer.		hp.json	solid tumor monitoring	http://purl.obolibrary.org/obo/MAXO_0000755		
OBO:MAXO_0000752	biolink:NamedThing	bone marrow aspiration	Removal of a small amount of liquid bone marrow through a needle.		hp.json	bone marrow aspiration procedure	http://purl.obolibrary.org/obo/MAXO_0000752		
OBO:MAXO_0000753	biolink:NamedThing	bone marrow examination	The pathologic analysis of samples of bone marrow obtained by bone marrow biopsy and bone marrow aspiration.		hp.json	bone marrow testing|bone marrow monitoring	http://purl.obolibrary.org/obo/MAXO_0000753		
HP:0008187	biolink:PhenotypicFeature	Absence of secondary sex characteristics	No secondary sexual characteristics are present at puberty.	UMLS:C4021551	hp.json	No secondary sexual characteristics at puberty	http://purl.obolibrary.org/obo/HP_0008187		
HP:0008186	biolink:PhenotypicFeature	Adrenocortical cytomegaly	The presence of large polyhedral cells with eosinophilic granular cytoplasm and enlarged nuclei in the adrenal cortex.	UMLS:C1851720	hp.json		http://purl.obolibrary.org/obo/HP_0008186		
HP:0008189	biolink:PhenotypicFeature	Insulin insensitivity	Decreased sensitivity toward insulin.	UMLS:C1864570	hp.json		http://purl.obolibrary.org/obo/HP_0008189		
HP:0008188	biolink:PhenotypicFeature	Thyroid dysgenesis		UMLS:C1563716|MSH:D050033	hp.json	Thyroid dysplasia	http://purl.obolibrary.org/obo/HP_0008188		
HP:0033125	biolink:PhenotypicFeature	Follicular lymphoma	An indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, splenomegaly and less commonly other extranodal sites of involvement.		hp.json		http://purl.obolibrary.org/obo/HP_0033125		
HP:0033124	biolink:PhenotypicFeature	Increased serum sorbitol concentration	An increased level of sorbitol in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033124		
HP:0033127	biolink:PhenotypicFeature	Abnormality of the musculoskeletal system	An anomaly of the musculoskeletal system, which consists of the bones of the skeleton, muscles, cartilage, tendons, ligaments, joints, and other connective tissue. The musculoskeletal system supports the weight of the body, maintains body position and produces movements of the body or of parts of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0033127		
HP:0033126	biolink:PhenotypicFeature	Cutaneous necrosis	Skin and subcutaneous tissue necrosis (tissue death). Clinically, cutaneous necrosis may present as a painful and extremely tender black eschar (dead tissue found in a full-thickness wound) surrounded by dusky grey-red coloured skin.		hp.json	Skin necrosis	http://purl.obolibrary.org/obo/HP_0033126		
HP:0033121	biolink:PhenotypicFeature	Barking cough	A cough with a characteristic sound that has been compared to a seal's bark.		hp.json	Seal-like barking cough	http://purl.obolibrary.org/obo/HP_0033121		
HP:0033120	biolink:PhenotypicFeature	Nummular eczema	A type of eczema characterized by pruritic coin-shaped patches on the skin. Nummular eczema most commonly occurs on the extremities, particularly the legs, but may occur anywhere on the trunk, hands, or feet		hp.json	Discoid eczema|Nummular dermatitis	http://purl.obolibrary.org/obo/HP_0033120		
HP:0033123	biolink:PhenotypicFeature	Elevated circulating osteopontin level	Abnormally increased level of osteopontin in the blood circulation		hp.json		http://purl.obolibrary.org/obo/HP_0033123		
HP:0033122	biolink:PhenotypicFeature	Absent P wave	The P wave that normally precedes each QRS complex by a fixed PR interval of 120 to 200 milliseconds is not present.		hp.json	Absence of P wave on electrocardiography	http://purl.obolibrary.org/obo/HP_0033122		
GO:0036035	biolink:BiologicalProcess	osteoclast development	The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.		hp.json	osteoclast cell development	http://purl.obolibrary.org/obo/GO_0036035		
OBO:MAXO_0000707	biolink:NamedThing	pediatrician evaluation	An assessment by a specialist concerned with the physical, emotional, and social health of children from birth to young adulthood.		hp.json	evaluation by pediatrician|pediatrician consultation	http://purl.obolibrary.org/obo/MAXO_0000707		
OBO:MAXO_0000705	biolink:NamedThing	hand surgeon evaluation	An assessment by a specialist with expertise in the surgical, medical and rehabilitative care of patients with diseases, injuries, and disorders affecting the hand, wrist and forearm.		hp.json	hand surgeon consultation|referral to orthopedic hand surgeon|consultation with orthopedic hand surgeon|consultation with hand surgeon|referral to hand surgeon	http://purl.obolibrary.org/obo/MAXO_0000705		
OBO:MAXO_0000706	biolink:NamedThing	otolaryngologist evaluation	An assessment by a specialist who provides medical and/or surgical therapy or prevention of diseases, allergies, neoplasms, deformities, disorders and/or injuries of the ears, nose, sinuses, throat, respiratory and upper alimentary systems, face, jaws and the other head and neck systems.		hp.json	otolaryngology specialist consultation|evaluation by otolaryngologist|consultation by otolaryngology specialist|consultation with otolaryngologist|head and neck surgeon referral|referral to otolaryngologist|otolaryngologist referral|head and neck surgeon evaluation|head and neck surgeon consultation|referral to head and neck surgeon|otolaryngologist consultation|consultation with head and neck surgeon|otolaryngology specialist referral|otolaryngology specialist evaluation	http://purl.obolibrary.org/obo/MAXO_0000706		
HP:0033129	biolink:PhenotypicFeature	Abnormal shoulder physiology	Anopmalous function of the shoulder. The shoulder is a ball-and-socket joint that is made up of humerus, scapula and clavicle, which are connected by the sternoclavicular joint (SC), the acromioclavicular joint (AC), the glenohumeral joint (GH), and the scapulothoracic joint (ST). The GH, AC and SC joints link the upper extremity to the axial skeleton at the thorax and enable movement at the shoulder joint: flexion, extension, and rotation of the arm.		hp.json		http://purl.obolibrary.org/obo/HP_0033129		
HP:0033128	biolink:PhenotypicFeature	Delayed ability to crawl	A failure to achieve the ability to crawl at an appropriate developmental stage. Normal infant motor development is marked by a series of postural milestones including learning to crawl on hands and knees between the ages of 6 and 10 months.		hp.json		http://purl.obolibrary.org/obo/HP_0033128		
OBO:MAXO_0000709	biolink:NamedThing	developmental-behavior pediatrician evaluation	An evaluation with a specialist who possesses special skills, training and experience to foster understanding and promotion of optimal development of children and families through research, education, clinical care and advocacy efforts. This physician assists in the prevention, diagnosis and management of developmental difficulties and problematic behaviors in children and in the family dysfunctions that compromise children’s development.		hp.json	referral to developmental-behavior pediatrician|developmental-behavior pediatrician consultation|consultation with developmental-behavior pediatrician|developmental-behavior pediatrician referral	http://purl.obolibrary.org/obo/MAXO_0000709		
PR:000001345	biolink:Protein	endoglin	A protein that is a translation product of the human ENG gene or a 1:1 ortholog thereof.	PIRSF:PIRSF038746|IUPHARobj:2895	hp.json	CD105|END|ENG|Edg|cell surface MJ7/18 antigen	http://purl.obolibrary.org/obo/PR_000001345		
OBO:MAXO_0000700	biolink:NamedThing	neurological surgery specialist evaluation	An assessment by this specialist provides care for adult and pediatric patients in the treatment of pain or pathological processes that may modify the function or activity of the central nervous system (e.g., brain, hypophysis, and spinal cord), the peripheral nervous system (e.g., cranial, spinal, and peripheral nerves), the autonomic nervous system, the supporting structures of these systems (e.g., meninges, skull & skull base, and vertebral column), and their vascular supply (e.g., intracranial, extracranial, and spinal vasculature).	NCIT:C17722	hp.json	neurosurgeon evaluation|neurosurgeon consultation|consultation with neurosurgeon|referral to neurosurgeon|neurological surgeon evaluation|neurological surgeon consultation|consultation with neurological surgeon|neurological surgery specialist consultation|consultation with neurological surgery specialist	http://purl.obolibrary.org/obo/MAXO_0000700		
OBO:MAXO_0000703	biolink:NamedThing	ophthalmologist evaluation	An evaluation by a specialist focused on the medical and surgical care of the eyes. Ophthalmologists are the only physicians medically trained to manage the complete range of the eye and vision care. They can prescribe glasses and contact lenses, dispense medications, diagnose and treat eye conditions and diseases and perform surgeries.		hp.json	referral to ophthalmologist|ophthalmologist consultation|consultation with ophthalmologist|ophthalmology specialist evaluation|referral to ophthalmology specialist|ophthalmology specialist consultation|referral to optometrist|ophthalmologist referral	http://purl.obolibrary.org/obo/MAXO_0000703		
OBO:MAXO_0000704	biolink:NamedThing	sports medicine orthopedist evaluation	An evaluation by a specialist who has expertise in the surgical and medical care for all structures of the musculoskeletal system directly affected by participation in sporting activity. This specialist is proficient in areas including conditioning, training and fitness, athletic performance and the impact of dietary supplements, pharmaceuticals, and nutrition on performance and health, coordination of care within the team setting utilizing other health care professionals, field evaluation and management, soft tissue biomechanics and injury healing and repair. Knowledge and understanding of the principles and techniques of rehabilitation, athletic equipment and orthotic devices enables the specialist to prevent and manage athletic injuries.		hp.json	referral to sports medicine orthopedist|sports medicine orthopedist consultation|sports medicine orthopedic surgeon evaluation|consultation with sports medicine orthopedic surgeon|sports medicine orthopedic surgeon consultation|referral to sports medicine orthopedic surgeon|sports medicine orthopedist referral	http://purl.obolibrary.org/obo/MAXO_0000704		
OBO:MAXO_0000701	biolink:NamedThing	nuclear medicine specialist evaluation	An evaluation by a specialist that uses molecular tracers (usually labeled with radioactive atoms) for diagnosis and therapy.		hp.json	referral to nuclear medicine specialist|consultation with nuclear medicine specialist|nuclear medicine specialist consultation	http://purl.obolibrary.org/obo/MAXO_0000701		
OBO:MAXO_0000702	biolink:NamedThing	obstetrics and gynecology specialist evaluation	An evaluation with a specialist who focuses on the health of women before, during and after childbearing years, diagnosing and treating conditions of the reproductive system and associated disorders.		hp.json	consultation with obstetrics and gynecology specialist|OB/GYN specialist evaluation|obstetrics/gynecology specialist evaluation|consultation OB/GYN specialist|OB/GYN specialist consultation|obstetrics/gynecology specialist consultation|consultation obstetrician/gynecologist|obstetrics and gynecology specialist consultation|obstetrician/gynecologist evaluation|referral to OB/GYN specialist|obstetrician/gynecologist consultation	http://purl.obolibrary.org/obo/MAXO_0000702		
HP:0033130	biolink:PhenotypicFeature	Abnormal renal echogenicity	Anomalous echogenicity of the kidney on ultrasound examination.		hp.json		http://purl.obolibrary.org/obo/HP_0033130		
GO:0051607	biolink:BiologicalProcess	defense response to virus	Reactions triggered in response to the presence of a virus that act to protect the cell or organism.		hp.json	antiviral response|defence response to virus|defense response to viruses	http://purl.obolibrary.org/obo/GO_0051607		
HP:0033136	biolink:PhenotypicFeature	Lymph node abscess	An inflammed lymph node that is filled with pus.		hp.json		http://purl.obolibrary.org/obo/HP_0033136		
HP:0033135	biolink:PhenotypicFeature	Hepatic infarction	Hepatic infarction is defined as areas of coagulative necrosis from hepatocyte cell death caused by local ischemia. Liver infarctions appear as hypoechoic nonvascular regions on conventional and Doppler sonography.		hp.json		http://purl.obolibrary.org/obo/HP_0033135		
HP:0033138	biolink:PhenotypicFeature	Right atrial thrombus	A thrombus (i.e., a blood clot formed in situ within the vascular system) located in the right atrium of the heart.		hp.json		http://purl.obolibrary.org/obo/HP_0033138		
GO:0051606	biolink:BiologicalProcess	detection of stimulus	The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.		hp.json	stimulus sensing|stimulus detection|perception of stimulus	http://purl.obolibrary.org/obo/GO_0051606		goslim_pir
HP:0033137	biolink:PhenotypicFeature	Abnormal pulmonary alveolar system morphology	A structural abnormality of the pulmonary acinus, alveolar parenchyma, or alveoli.		hp.json		http://purl.obolibrary.org/obo/HP_0033137		
HP:0033132	biolink:PhenotypicFeature	Renal cortical hyperechogenicity	Increased echogenecity of the kidney cortex.		hp.json		http://purl.obolibrary.org/obo/HP_0033132		
GO:0000096	biolink:BiologicalProcess	sulfur amino acid metabolic process	The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.		hp.json	sulfur amino acid metabolism|sulphur amino acid metabolic process|sulphur amino acid metabolism	http://purl.obolibrary.org/obo/GO_0000096		
HP:0033131	biolink:PhenotypicFeature	Renal medullary hyperechogenicity	Increased echogenecity of the medullary region of the kidney.		hp.json	Increased renal medullary echogenicity	http://purl.obolibrary.org/obo/HP_0033131		
HP:0033134	biolink:PhenotypicFeature	Abdominal adhesions	Fibrous bands (i.e., bands of scar-like tissue) that span two or more intra-abdominal organs and/or the inner abdominal wall (i.e. peritoneal membrane).		hp.json	Intra-abdominal adhesion	http://purl.obolibrary.org/obo/HP_0033134		
HP:0033133	biolink:PhenotypicFeature	Renal cortical hypoechogeneity			hp.json	Hypoechogenic renal cortex	http://purl.obolibrary.org/obo/HP_0033133		
PR:000001355	biolink:Protein	immunoglobulin gamma Fc receptor II/III/IV	A protein with a core domain architecture consisting of an extracellular domain containing two copies of the Immunoglobulin domain (Pfam:PF00047), followed by a single-pass transmembrane region and a small intracellular domain. The active protein is a low affinity receptor for immunoglobulin gamma chain Fc region. Human II-a, II-b, and II-c represent a recent gene expansion and are equally related to mouse II, III, and IV. Human III-A and III-B are closely related and closer to mouse IV than to mouse III.	PIRSF:PIRSF001980	hp.json		http://purl.obolibrary.org/obo/PR_000001355		
HP:0033139	biolink:PhenotypicFeature	Elevated circulating uracil concentration	Concentration of uracil in the blood circulation is above the normal range.		hp.json		http://purl.obolibrary.org/obo/HP_0033139		
HP:0033141	biolink:PhenotypicFeature	Severe SARS-CoV-2 infection	Unusually severe clinical course of SARS-CoV-2 infection, manifested clinically by features such as dyspnea and hypoxia with diffuse bilateral ground-glass opacities of the lungs on computed tomographic scan with progressive respiratory insufficiency necessitating oxygen supplementation or mechanical ventilation.		hp.json		http://purl.obolibrary.org/obo/HP_0033141		
HP:0033140	biolink:PhenotypicFeature	Blake's pouch cyst	The presence of an upwardly displaced normal cerebellar vermis, normal appearance of the fastigium, tentorium and size of the cisterna magna.		hp.json		http://purl.obolibrary.org/obo/HP_0033140		
UBERON:5001466	biolink:AnatomicalEntity	pedal digit plus metapodial segment	A subdivision of the autopod consisting of pedal digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	pedal digit digitopodial subdivision|pedal digit ( phalanges plus metapodial) plus soft tissue|pedal digit ray|pedal digit	http://purl.obolibrary.org/obo/UBERON_5001466		
HP:0033147	biolink:PhenotypicFeature	Abnormal circulating short-chain fatty-acid concentration	Any deviation from the normal concentration of a short-chain fatty acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033147		
HP:0033146	biolink:PhenotypicFeature	Elevated circulating methylsuccinic acid concentration	Increased concentration of methylsuccinic acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033146		
HP:0033149	biolink:PhenotypicFeature	Intrahepatic bile duct dilatation	Increased diameter (caliber) of intrahepatic bile ducts (bile ducts that transport bile between the Canals of Hering and the interlobar bile ducts).		hp.json	Dilatation of intrahepatic biliary ducts	http://purl.obolibrary.org/obo/HP_0033149		
CHEBI:63394	biolink:ChemicalSubstance	ketoaldonic acid derivative	A monosaccharide derivative that is formally obtained from a ketoaldonic acid.		hp.json	ketoaldonic acid derivatives	http://purl.obolibrary.org/obo/CHEBI_63394		3_STAR
HP:0033148	biolink:PhenotypicFeature	Increased circulating isovaleric acid concentration	Increased concentration of isovaleric acid, a C5, branched-chain saturated fatty acid, in the blood concentration.		hp.json	Isovalericacidemia|Increased circulating isovalerate	http://purl.obolibrary.org/obo/HP_0033148		
HP:0033143	biolink:PhenotypicFeature	Jejunitis	Inflammation of the lining of the middle section of the small intestine.		hp.json		http://purl.obolibrary.org/obo/HP_0033143		
HP:0033142	biolink:PhenotypicFeature	Long nasal bridge	Increased superior-inferior length of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose.		hp.json		http://purl.obolibrary.org/obo/HP_0033142		
HP:0033145	biolink:PhenotypicFeature	Increased circulating ceruloplasmin concentration	Elevated concentration of ceruloplasmin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033145		
HP:0033144	biolink:PhenotypicFeature	Abnormal circulating ceruloplasmin concentration	Any deviation of the concentration of ceruloplasmin in the blood from the normal range.		hp.json		http://purl.obolibrary.org/obo/HP_0033144		
OBO:MAXO_0000729	biolink:NamedThing	transrectal ultrasonography	A procedure that uses sound waves to create a video image of the pelvic organs and tissues. A small, lubricated probe placed into the rectum releases sound waves, which create echoes as they enter a pelvic organ. The echoes that bounce back are sent to a computer that translates the pattern of echoes into a picture of the specific organ under examination.  This procedure is most often used to evaluate the prostate gland.	NCIT:C18315	hp.json	medical transrectal ultrasound|endorectal ultrsonography|TRUS|ERUS|diagnostic transrectal ultrasound|endorectal sonography|transrectal sonography|endorectal ultrasound|transrectal ultrasound examination|transrectal ultrasound	http://purl.obolibrary.org/obo/MAXO_0000729		
OBO:MAXO_0000727	biolink:NamedThing	intravascular ultrasonography	An invasive procedure in which sound waves (called ultrasound) are bounced off of vascular tissues from within the vessel and the echoes produce a picture (sonogram).	NCIT:C99535	hp.json	IVUS|intravascular sonography|medical intravascular ultrasonography|intravascular ultrasound|diagnostic intravascular ultrasound	http://purl.obolibrary.org/obo/MAXO_0000727		
OBO:MAXO_0000728	biolink:NamedThing	transvaginal ultrasonography	A technique in which sound waves are sent out by an ultrasound probe that has been inserted in the vagina and a computer uses the ultrasound echoes to create an image of the female genital tract. The test can be performed to evaluate women with infertility problems, abnormal bleeding, sources of unexplained pain, congenital malformations of the uterus and ovaries, and possible tumors and infection.	NCIT:C17644	hp.json	diagnostic transvaginal ultrasound|medical transvaginal sonography|transvaginal sonography|transvaginal ultrasound examination|transvaginal ultrasound|TVU|TVS	http://purl.obolibrary.org/obo/MAXO_0000728		
OBO:MAXO_0000721	biolink:NamedThing	thoracic and cardiac surgeon evaluation	Evaluation by a specialist who focuses on the operative, perioperative, and surgical critical care of patients with acquired and congenital pathologic conditions within the chest.		hp.json	thoracic and cardiac surgeon consultation|evaluation by thoracic and cardiac surgeon|evaluation by thoracic surgeon|consultation with thoracic and cardiac surgeon|referral to thoracic and cardiac surgeon|consultation with thoracic surgeon|referral to thoracic surgeon|thoracic surgeon assessment|thoracic and cardiac surgeon assessment|assessment by thoracic and cardiac surgeon|thoracic surgeon referral|thoracic surgeon evaluation|assessment by thoracic surgeon|thoracic and cardiac surgeon referral	http://purl.obolibrary.org/obo/MAXO_0000721		
OBO:MAXO_0000722	biolink:NamedThing	urologist evaluation	An evaluation by a specialist that focuses on diagnosing and treating disorders of the urinary tracts of males and females, and on the reproductive system of males. This specialist manages non-surgical problems such as urinary tract infections and benign prostatic hyperplasia, as well as surgical problems such as the surgical management of cancers, the correction of congenital abnormalities, and correcting stress incontinence.		hp.json	referral to urologist|urologist referral|consultation with urologist|assessment by genitourinary surgeon|evaluation by urologist|urologist consultation|referral to genitourinary surgeon|genitourinary surgeon evaluation|assessment by urologist|consultation with genitourinary surgeon|genitourinary surgeon consultation|urologist assessment|evaluation by genitourinary surgeon	http://purl.obolibrary.org/obo/MAXO_0000722		
OBO:MAXO_0000720	biolink:NamedThing	vascular surgeon evaluation	An evaluation by a specialist who performs preoperative, operative, and postoperative management of patients with disorders of the arterial, venous and lymphatic systems, excluding vessels of the brain and the heart.		hp.json	referral by vascular surgeon|evaluation by vascular surgeon|vascular surgeon assessment|vascular surgeon referral|assessment by vascular surgeon|vascular surgeon consultation	http://purl.obolibrary.org/obo/MAXO_0000720		
PR:000001327	biolink:Protein	cadherin	A protein that has a core domain structure of signal sequence, propeptide, five Cadherin domains (Pfam:PF00028), a transmembrane region, and a Cadherin cytoplasmic region (Pfam:PF01049). Cadherins function as adhesion molecules that mediate Ca2+-dependent cell-cell adhesion in solid tissues.	PIRSF:PIRSF002504	hp.json		http://purl.obolibrary.org/obo/PR_000001327		
OBO:MAXO_0000725	biolink:NamedThing	surgeon evaluation	Assessment by a specialist who has expertise in the diagnosis and preoperative, operative, and postoperative management of patient care.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000725		
OBO:MAXO_0000726	biolink:NamedThing	hysterosonography	A procedure, also known as sonohysterography or saline infusion sonography, using a minimally invasive ultrasound technique to view the inside of the uterus. Sterile saline is injected into the endometrial cavity thereby distending the endometrial cavity, providing good visualization of the anatomic structures within.	NCIT:C38066	hp.json	medical hysterosonography|saline infusion sonography|diagnostic hysterosonography|sonohysterography	http://purl.obolibrary.org/obo/MAXO_0000726		
OBO:MAXO_0000723	biolink:NamedThing	psychiatry and neurology specialist evaluation	Evaluation by a physician who specializes in the evaluation and treatment of of the brain.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000723		
GO:0051621	biolink:BiologicalProcess	regulation of norepinephrine uptake	Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell.		hp.json	regulation of noradrenaline uptake|regulation of levarterenol uptake|regulation of norepinephrine import	http://purl.obolibrary.org/obo/GO_0051621		
HP:0033150	biolink:PhenotypicFeature	Anorectal abscess	An abscess located at the junction of the anal canal and the rectum.		hp.json		http://purl.obolibrary.org/obo/HP_0033150		
GO:0051622	biolink:BiologicalProcess	negative regulation of norepinephrine uptake	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.		hp.json	negative regulation of levarterenol uptake|down-regulation of norepinephrine uptake|negative regulation of norepinephrine import|down regulation of norepinephrine uptake|downregulation of norepinephrine uptake|negative regulation of noradrenaline uptake	http://purl.obolibrary.org/obo/GO_0051622		
HP:0033152	biolink:PhenotypicFeature	Abnormal pharynx physiology	A functional anomaly of the pharynx.		hp.json		http://purl.obolibrary.org/obo/HP_0033152		
HP:0033151	biolink:PhenotypicFeature	Abnormal pharynx morphology	A structural anomaly of the pharynx.		hp.json		http://purl.obolibrary.org/obo/HP_0033151		
GO:0051620	biolink:BiologicalProcess	norepinephrine uptake	The directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.		hp.json	norepinephrine reuptake|levarterenol uptake|noradrenaline reuptake|norepinephrine import|noradrenaline uptake|levarterenol reuptake	http://purl.obolibrary.org/obo/GO_0051620		
GO:0051623	biolink:BiologicalProcess	positive regulation of norepinephrine uptake	Any process that activates or increases the frequency, rate or extent of the directed movement of norepinephrine into a cell.		hp.json	positive regulation of norepinephrine import|stimulation of norepinephrine uptake|upregulation of norepinephrine uptake|up-regulation of norepinephrine uptake|up regulation of norepinephrine uptake|positive regulation of levarterenol uptake|activation of norepinephrine uptake|positive regulation of noradrenaline uptake	http://purl.obolibrary.org/obo/GO_0051623		
HP:0033158	biolink:PhenotypicFeature	Reduced respiratory ciliary beating frequency	An abnormal reduction in the number of beats per unit time of the respiratory cilia.		hp.json	Dminished respiratory ciliary beat frequency	http://purl.obolibrary.org/obo/HP_0033158		
HP:0033157	biolink:PhenotypicFeature	Elevated circulating 3-methylhistidine concentration	Abnormal increase of the concentration of 3-methylhistidine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033157		
GO:0000070	biolink:BiologicalProcess	mitotic sister chromatid segregation	The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.		hp.json	mitotic sister-chromatid adhesion release|mitotic chromosome segregation	http://purl.obolibrary.org/obo/GO_0000070		goslim_pombe
HP:0033159	biolink:PhenotypicFeature	Reduced urinary inosine level	Decreased level of inosine in urine. Inosine is a purine nucleoside in which hypoxanthine is attached to ribofuranose via a beta-N(9)-glycosidic bond.		hp.json		http://purl.obolibrary.org/obo/HP_0033159		
HP:0033154	biolink:PhenotypicFeature	Elevated circulating deoxypyridinoline concentration	An increased concentration of lysyl-pyridinoline (deoxypyridinoline) cross-links in the bloood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033154		
HP:0033153	biolink:PhenotypicFeature	Elevated circulating dodecenoylcarnitine concentration	An abnormally increased circulation of dodecenoylcarnitine, C12:1, in the blood circulation.		hp.json	Elevated plasma dodecenoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0033153		
HP:0033156	biolink:PhenotypicFeature	Elevated urine L-alloisoleucine level	Abnormally increased level of L-alloisoleucine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033156		
HP:0033155	biolink:PhenotypicFeature	Elevated circulating L-alloisoleucine concentration	Abnormally increased concentration of L-alloisoleucine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033155		
OBO:MAXO_0000718	biolink:NamedThing	radiologist evaluation	Evaluation by a specialist who uses imaging methodologies to diagnose and manage patients and provide therapeutic options.		hp.json	evaluation by radiologist|assessment by radiologist|radiologist assessment	http://purl.obolibrary.org/obo/MAXO_0000718		
OBO:MAXO_0000719	biolink:NamedThing	general surgeon evaluation	Evaluation by an expert in the diagnosis and care of patients with diseases and disorders affecting the abdomen, digestive tract, endocrine system, breast, skin and blood vessels. A general surgeon is also trained in the treatment of patients who are injured or critically ill, and in the care of pediatric and cancer patients. General surgeons are skilled in the use of minimally invasive techniques and endoscopies.		hp.json	assessment by general surgeon|general surgeon evaluation|general surgeon consultation|consultation with general surgeon|evaluation by general surgeon|general surgeon assessment	http://purl.obolibrary.org/obo/MAXO_0000719		
OBO:MAXO_0000716	biolink:NamedThing	neurologist evaluation	An evaluation a specialist who treats all types of disease or impaired function of the brain, spinal cord, peripheral nerves, muscles and autonomic nervous system, as well as the blood vessels that relate to these structures.		hp.json	neurologist consultation|neurologist assessment|referral to neurologist|consultation with neurologist|neurologist referral	http://purl.obolibrary.org/obo/MAXO_0000716		
OBO:MAXO_0000717	biolink:NamedThing	child neurologist evaluation	Evaluation with a specialist who diagnose and treat all types of disease or impaired function of the brain, spinal cord, peripheral nerves, muscles and autonomic nervous system, as well as the blood vessels that relate to these structures in infants, children, and adolescents. They also have special competence in genetic and metabolic problems, malformation, retardation and other neurodevelopmental problems of childhood.		hp.json	pediatric neurologist evaluation|child neurologist consultation|referral to child neurologist|consultation with child neurologist|pediatric neurologist consultation|evaluation by child neurologist|assessment by pediatric neurologist|child neurologist assessment|pediatric neurologist assessment|referral to pediatric neurologist|consultation with pediatric neurologist	http://purl.obolibrary.org/obo/MAXO_0000717		
PR:000001332	biolink:Protein	carcinoembryonic antigen-related cell adhesion molecule 8	A protein that is a translation product of the human CEACAM8 gene or a 1:1 ortholog thereof.		hp.json	CEACAM8|CGM6|non-specific cross-reacting antigen NCA-95|CD66b|CD67 antigen|carcinoembryonic antigen CGM6	http://purl.obolibrary.org/obo/PR_000001332		
OBO:MAXO_0000710	biolink:NamedThing	pediatric endocrinologist evalutation	An evaluation by a specialist who provides expert care to infants, children and adolescents who have diseases that result from an abnormality in the endocrine glands (glands which secrete hormones). These diseases include diabetes mellitus, growth failure, unusual size for age, early or late pubertal development, birth defects, the genital region and disorders of the thyroid, the adrenal and pituitary glands.		hp.json	evaluation by pediatric endocrinologist|pediatric endocrinologist referral|assessment by pediatric endocrinologist|pediatric endocrinologist consultation|referral to pediatric endocrinologist|consultation with pediatric endocrinologist	http://purl.obolibrary.org/obo/MAXO_0000710		
OBO:MAXO_0000711	biolink:NamedThing	pediatric cardiologist evaluation	Evaluation by a specialist who provides comprehensive care to patients with cardiovascular problems. This specialist is skilled in selecting, performing, and evaluating the structural and functional assessment of the heart and blood vessels, and the clinical evaluation of cardiovascular disease.		hp.json	assessment by pediatric cardiologist|evaluation by pediatric cardiologist|pediatric cardiologist referral|consultation with pediatric cardiologist|referral to pediatric cardiologist|pediatric cardiologist consultation	http://purl.obolibrary.org/obo/MAXO_0000711		
UBERON:5001463	biolink:AnatomicalEntity	manual digit 1 plus metapodial segment	A subdivision of the autopod consisting of manual digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	manual digit I plus metapodial segment|manual digit 1 ( phalanges plus metapodial) plus soft tissue|manual digit 1 ray|manual digit 1 digitopodial subdivision|manual digit 1	http://purl.obolibrary.org/obo/UBERON_5001463		
OBO:MAXO_0000714	biolink:NamedThing	psychiatrist evaluation	Evaluation by a physician who specializes in the evaluation and treatment of mental, addictive and emotional disorders.		hp.json	psychiatrist assessment|assessment by psychiatrist|psychiatrist referral|psychiatrist consultation|consult with psychiatrist|evaluation by psychiatrist|referral to psychiatrist	http://purl.obolibrary.org/obo/MAXO_0000714		
OBO:MAXO_0000715	biolink:NamedThing	child and adolescent psychiatrist evaluation	Evaluation by a physician who specializes in the evaluation and treatment of mental, addictive and emotional disorders in children and adolescence.		hp.json	assessment by child and adolescent psychiatrist|assessment by child psychiatrist|child and adolescent psychiatrist referral|child psychiatrist assessment|referral to child and adolescent psychiatrist|child and adolescent psychiatrist consultation|consultation with child and adolescent psychiatrist|evaluation by child and adolescent psychiatrist|child psychiatrist referral|consultation with child psychiatrist|child psychiatrist evaluation|referral to child psychiatrist|child and adolescent psychiatrist assessment	http://purl.obolibrary.org/obo/MAXO_0000715		
OBO:MAXO_0000712	biolink:NamedThing	physiatrist evaluation	Assessment by a specialist who treats patients with disorders or disabilities in the muscles, bones, and nervous system, including neck or back pain, sports and work injuries, stroke, brain injury, spinal cord injury, spasticity, and any other disability or disorder that affects function.		hp.json	physical medicine and rehabilitation specialist assessment|assessment by physiatrist|physiatrist consultation|consultation with physical medicine and rehabilitation specialist|evaluation by physical medicine and rehabilitation specialist|physical medicine and rehabilitation specialist referral|physical medicine and rehabilitation specialist evaluation|consultation by physiatrist|physiatrist assessment|referral to physiatrist|assessment by physical medicine and rehabilitation specialist|physical medicine and rehabilitation specialist consultation|physiatrist referral	http://purl.obolibrary.org/obo/MAXO_0000712		
OBO:MAXO_0000713	biolink:NamedThing	plastic surgeon evaluation	An assessment with a specialist who focuses on the repair, reconstruction or replacement of physical defects of form or function involving the skin, musculoskeletal system, craniomaxillofacial structures, hand, extremities, breast and trunk and external genitalia or cosmetic enhancement of these areas of the body.		hp.json	consultation with plastic surgeon|evaluation by plastic surgeon|plastic surgeon assessment|plastic surgeon referral|plastic surgeon consultation	http://purl.obolibrary.org/obo/MAXO_0000713		
HP:0011530	biolink:PhenotypicFeature	Retinal hole	A small break in the retina.	SNOMEDCT_US:95690009|MSH:D012167|SNOMEDCT_US:232003005|SNOMEDCT_US:302888003|UMLS:C0035321|SNOMEDCT_US:40024006	hp.json	Retinal holes	http://purl.obolibrary.org/obo/HP_0011530		
HP:0011531	biolink:PhenotypicFeature	Vitritis	Inflammation of the vitreous body, characterized by the presence of inflammatory cells and protein exudate in the vitreous cavity.	SNOMEDCT_US:95802009|UMLS:C0235812	hp.json	Hyalitis|Vitreitis	http://purl.obolibrary.org/obo/HP_0011531		hposlim_core
CHEBI:28963	biolink:ChemicalSubstance	amino sugar	Any sugar having one or more alcoholic hydroxy groups replaced by substituted or unsubstituted amino groups.	PMID:9056391|PMID:18424273|KEGG:C05383	hp.json	aminosugar|Aminosugars|amino sugars	http://purl.obolibrary.org/obo/CHEBI_28963		3_STAR
HP:0011532	biolink:PhenotypicFeature	Subretinal exudate	A type of retinal exudate located in the subretinal space between the sensory retina and the retinal pigment epithelium.	SNOMEDCT_US:247156002|UMLS:C0423431	hp.json		http://purl.obolibrary.org/obo/HP_0011532		
HP:0011533	biolink:PhenotypicFeature	Snowflake vitreoretinal degeneration	The appearance of yellow/white crystalline-like (hence the name) spots in the retina and thickening of the peripheral part of the vitreous.	UMLS:C1860405|MSH:C536677	hp.json	Snowflake retinal degeneration	http://purl.obolibrary.org/obo/HP_0011533		
HP:0011534	biolink:PhenotypicFeature	Abnormal spatial orientation of the cardiac segments	Abnormality of the spatial relationship of the cardiac segments to other components of the heart.	UMLS:C4023313	hp.json		http://purl.obolibrary.org/obo/HP_0011534		
CHEBI:28965	biolink:ChemicalSubstance	dicarboxylic acid dianion	A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid.		hp.json	dicarboxylic acid dianions|a dicarboxylate|dicarboxylate|dicarboxylates|dicarboxylic acid dianion	http://purl.obolibrary.org/obo/CHEBI_28965		3_STAR
UBERON:0035322	biolink:AnatomicalEntity	right common iliac artery		NCIT:C33474|FMA:14765	hp.json	trunk of right common iliac arterial tree	http://purl.obolibrary.org/obo/UBERON_0035322		human_reference_atlas
GO:0097194	biolink:BiologicalProcess	execution phase of apoptosis	A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.		hp.json	apoptosis|execution phase of apoptotic process	http://purl.obolibrary.org/obo/GO_0097194		
GO:0097190	biolink:BiologicalProcess	apoptotic signaling pathway	The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.		hp.json	induction of apoptosis by extracellular signals|apoptotic signalling pathway	http://purl.obolibrary.org/obo/GO_0097190		
UBERON:0011349	biolink:AnatomicalEntity	pterygomandibular raphe	The pterygomandibular raphe (pterygomandibular ligament) is a tendinous band of the buccopharyngeal fascia, attached by one extremity to the hamulus of the medial pterygoid plate, and by the other to the posterior end of the mylohyoid line of the mandible. Its medial surface is covered by the mucous membrane of the mouth. Its lateral surface is separated from the ramus of the mandible by a quantity of adipose tissue. Its posterior border gives attachment to the superior pharyngeal constrictor muscle. Its anterior border attaches to the posterior edge of the buccinator.	FMA:55618	hp.json	pterygomandibular ligament|pterygomandibular raph%c3%a9	http://purl.obolibrary.org/obo/UBERON_0011349		
UBERON:0035316	biolink:AnatomicalEntity	prostatic capsule	The membrane the surrounds the prostate gland.	FMA:19583|NCIT:C13086	hp.json	capsule of prostate gland|capsule of prostate	http://purl.obolibrary.org/obo/UBERON_0035316		
GO:0120054	biolink:BiologicalProcess	intestinal motility	Contractions of the intestinal tract that include peristalsis (moving contents onward) and non-peristaltic movement (moving contents back and forth).		hp.json		http://purl.obolibrary.org/obo/GO_0120054		
CHEBI:41941	biolink:ChemicalSubstance	(3,4-dihydroxyphenyl)acetic acid	A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.	PMID:11681538|Wikipedia:DOPAC|PMID:4420192|PMID:18706927|PDBeChem:DHY|PMID:22770225|PMID:11251641|PMID:15212971|PMID:11868042|CAS:102-32-9|Reaxys:2211017|DrugBank:DB01702|Beilstein:2211017|PMID:19191673|HMDB:HMDB0001336|PMID:15862791|CAS:102-32-9|KEGG:C01161|Gmelin:874810|CAS:102-32-9	hp.json	(3,4-dihydroxyphenyl)acetic acid|2-(3,4-DIHYDROXYPHENYL)ACETIC ACID|3,4-Dihydroxyphenylacetic acid|homoprotocatechuic acid|3,4-Dihydroxyphenyl acetic acid|dopacetic acid|3,4-dihydroxyphenylacetic acid	http://purl.obolibrary.org/obo/CHEBI_41941		3_STAR
HP:0011535	biolink:PhenotypicFeature	Abnormal atrial arrangement	Abnormality of the spatial relationship of the atria to other components of the heart.	UMLS:C2959688|SNOMEDCT_US:445898001	hp.json	Abnormal location of heart atrium	http://purl.obolibrary.org/obo/HP_0011535		
HP:0011536	biolink:PhenotypicFeature	Right atrial isomerism	Right atrial isomerism is characterized by bilateral triangular, morphologically right atrial, appendages, both joining the atrial chamber along a broad front with internal terminal crest.	MSH:D059446|UMLS:C3178806	hp.json		http://purl.obolibrary.org/obo/HP_0011536		
HP:0011537	biolink:PhenotypicFeature	Left atrial isomerism	In left atrial isomerism there is a bilateral small finger-shaped morphologically left atrial appendage joining the atrial chamber along a narrow front without an internal terminal crest.	EPCC:03.01.05|ICD-10:Q20.6|MSH:D059446|UMLS:C3178807	hp.json		http://purl.obolibrary.org/obo/HP_0011537		
HP:0011538	biolink:PhenotypicFeature	Atrial situs inversus	Mirror image atrial arrangement, with morphologic right atrium on the left hand side and morphologic left atrium on the right hand side.	EPCC:03.01.03|Fyler:0150|UMLS:C4023312|ICD-10:Q89.3|Fyler:150	hp.json		http://purl.obolibrary.org/obo/HP_0011538		
HP:0011539	biolink:PhenotypicFeature	Atrial situs ambiguous	Common atrium without defining morphologic features.	UMLS:C3164429|SNOMEDCT_US:448681000	hp.json	Atrial situs ambiguus|Atrial heterotaxy	http://purl.obolibrary.org/obo/HP_0011539		
HP:0011520	biolink:PhenotypicFeature	Deuteranomaly	A type of anomalous trichromacy associated with abnormal M photopigment, such that the absorption spectrum is shifted toward L wavelengths. Affected individuals have difficulties distinguishing between red and green.	SNOMEDCT_US:77479002|MSH:D003117|UMLS:C0155016|SNOMEDCT_US:246674000	hp.json	Deuteranomoly|Green-weak	http://purl.obolibrary.org/obo/HP_0011520		
HP:0011521	biolink:PhenotypicFeature	Deuteranopia	Complete lack of the M photopigment, which is replaced with the L photopigment. Affected individuals tend to confuse red and green.	SNOMEDCT_US:77479002|MSH:D003117|UMLS:C0155016|SNOMEDCT_US:246674000	hp.json	Green-blind	http://purl.obolibrary.org/obo/HP_0011521		
HP:0011522	biolink:PhenotypicFeature	Protanopia	Blue and green cones only; no functional red cones.	SNOMEDCT_US:51445007|MSH:D003117|UMLS:C0155015	hp.json	Red-blind	http://purl.obolibrary.org/obo/HP_0011522		
CHEBI:28976	biolink:ChemicalSubstance	carbonic acid		CAS:463-79-6|CAS:463-79-6|Gmelin:25554|PDBeChem:CO3|KEGG:C01353	hp.json	carbonic acid|H2CO3|dihydroxidooxidocarbon|Dihydrogen carbonate|Carbonic acid|Koehlensaeure|H2CO3|[CO(OH)2]	http://purl.obolibrary.org/obo/CHEBI_28976		3_STAR
HP:0011523	biolink:PhenotypicFeature	Iris cyst	An iris cyst is composed of a single cell layer of epithelium and is filled with fluid.	UMLS:C0271119|SNOMEDCT_US:37761009	hp.json		http://purl.obolibrary.org/obo/HP_0011523		
UBERON:0011342	biolink:AnatomicalEntity	surface of mandible	An anatomical surface that is part of a mandible.	FMA:57558	hp.json	mandibular surface	http://purl.obolibrary.org/obo/UBERON_0011342		
UBERON:0011344	biolink:AnatomicalEntity	lateral surface of mandible		FMA:59463	hp.json	lateral surface of ramus of mandible|external surface of ramus of mandible|lateral surface of mandibular ramus	http://purl.obolibrary.org/obo/UBERON_0011344		
HP:0011524	biolink:PhenotypicFeature	Iris melanoma	Malignant tumor of melanocytes affecting the iris.	SNOMEDCT_US:255012009|UMLS:C0346373|NCIT:C3224	hp.json		http://purl.obolibrary.org/obo/HP_0011524		
HP:0011525	biolink:PhenotypicFeature	Iris nevus	A benign brown pigmented area over the iris representing proliferation of melanocyte cells in the stromal layer of the iris. An iris nevus can be flat or occasionally slightly elevated.	UMLS:C0346376|SNOMEDCT_US:95711003	hp.json	Eye freckle	http://purl.obolibrary.org/obo/HP_0011525		
HP:0011526	biolink:PhenotypicFeature	Abnormality of lens shape	An abnormal shape of the lens.	UMLS:C4023314	hp.json	Abnormality of lens shape	http://purl.obolibrary.org/obo/HP_0011526		
HP:0011527	biolink:PhenotypicFeature	Lentiglobus	Exaggerated curvature of the lens of the eye, producing an anterior or posterior spherical bulging.	UMLS:C4280322|SNOMEDCT_US:419281007|UMLS:C1622439	hp.json	Bulging of eye lens	http://purl.obolibrary.org/obo/HP_0011527		hposlim_core
HP:0011528	biolink:PhenotypicFeature	Solitary congenital hypertrophy of retinal pigment epithelium	Sharply demarcated hyperpigmentation which is congenital found in around 3-5% of the population and of no functional significance.	UMLS:C4021145	hp.json	Single isolated CHRPE|Single isolated congenital hypertrophy of retinal pigment epithelium	http://purl.obolibrary.org/obo/HP_0011528		
HP:0011529	biolink:PhenotypicFeature	Multiple bilateral congenital hypertrophy of retinal pigment epithelium	Sharply demarcated hyperpigmentation which is congenital.	UMLS:C4021144	hp.json	Multiple bilateral CHRPE	http://purl.obolibrary.org/obo/HP_0011529		
HP:0011510	biolink:PhenotypicFeature	Drusen	Drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in Bruch's membrane of the eye.	SNOMEDCT_US:18695008|UMLS:C1260959	hp.json		http://purl.obolibrary.org/obo/HP_0011510		
HP:0011511	biolink:PhenotypicFeature	Macular schisis	Splitting of the retina in the macular region.	UMLS:C4023321	hp.json		http://purl.obolibrary.org/obo/HP_0011511		
HP:0011512	biolink:PhenotypicFeature	Hyperpigmentation of the fundus	Increased pigmentation of the fundus	UMLS:C4021146	hp.json	Hyperpigmented fundus|Hyperpigmented fundi	http://purl.obolibrary.org/obo/HP_0011512		
CHEBI:28940	biolink:ChemicalSubstance	calciol	A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.	PDBeChem:VD3|PPDB:160|PMID:16886665|PMID:12174089|PMID:2997282|PMID:9627702|LIPID_MAPS_instance:LMST03020001|Gmelin:1267613|KEGG:D00188|PMID:19817701|HMDB:HMDB0000876|LIPID_MAPS_instance:LMST03020000|PMID:3494111|Wikipedia:Cholecalciferol|CAS:67-97-0|KEGG:C05443|PMID:11493580|PMID:2838261|CAS:67-97-0|DrugBank:DB00169|PMID:12955389|CAS:67-97-0|PMID:24304198|PMID:23964472|PMID:15214747|PMID:6265326|PMID:10347174|Drug_Central:2840|PMID:15876428|PMID:17156784|Reaxys:2339331|Beilstein:2339331|PMID:184223	hp.json	activated 7-dehydrocholesterol|(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol|calciol|Cholecalciferol|colecalciferol|Delta-D|CC|calciol|Vitamin D3|(1S,3Z)-3-[(2E)-2-[(1R,3AR,7AS)-7A-METHYL-1-[(2R)-6-METHYLHEPTAN-2-YL]-2,3,3A,5,6,7-HEXAHYDRO-1H-INDEN-4-YLIDENE]ETHYLIDENE]-4-METHYLIDENE-CYCLOHEXAN-1-OL|(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol|(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol|vitamin D3|(+)-vitamin D3|oleovitamin D3|Vitamin D3	http://purl.obolibrary.org/obo/CHEBI_28940		3_STAR
UBERON:0011332	biolink:AnatomicalEntity	extrinsic tongue pre-muscle mass		EMAPA:17884	hp.json		http://purl.obolibrary.org/obo/UBERON_0011332		
CHEBI:16997	biolink:ChemicalSubstance	propane-1,2-diol	The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.	Wikipedia:Propylene_glycol|PMID:16078503|HMDB:HMDB0001881|LINCS:LSM-36856|VSDB:1304|CAS:57-55-6|PPDB:1304|PMID:15665701|DrugBank:DB01839|CAS:57-55-6|PMID:21616561|CAS:57-55-6|Drug_Central:4024|PMID:18845115|KEGG:C00583|KEGG:D00078|KNApSAcK:C00007410|Reaxys:1340498|PMID:18346395	hp.json	1,2-dihydroxypropane|methylethyl glycol|PPD|propane-1,2-diol|methylethylene glycol|MeCH(OH)CH2OH|propane-1,2-diol|isopropylene glycol|monopropylene glycol|1,2-Propylenglykol|methyl glycol|Propylene glycol|HOCH2CH(OH)CH3|HOCH2CH(OH)Me|CH3CH(OH)CH2OH|Propane-1,2-diol|2-hydroxypropanol|alpha-propyleneglycol|1,2-Propanediol	http://purl.obolibrary.org/obo/CHEBI_16997		3_STAR
CHEBI:16995	biolink:ChemicalSubstance	oxalic acid	An alpha,omega-dicarboxylic acid that is ethane substituted by carboxyl groups at positions 1 and 2.	CAS:144-62-7|KEGG:C00209|Beilstein:385686|LIPID_MAPS_instance:LMFA01170031|Reaxys:385686|CAS:144-62-7|PDBeChem:OXD|PMID:15587083|PMID:22735334|CAS:144-62-7|KNApSAcK:C00001198|HMDB:HMDB0002329|Gmelin:2208|DrugBank:DB03902|MetaCyc:OXALATE|Wikipedia:Oxalic_acid	hp.json	ethane-1,2-dioic acid|Oxalsaeure|H2ox|oxalic acid|Ethanedioic acid|Ethandisaeure|Oxalic acid|HOOCCOOH|OXALIC ACID	http://purl.obolibrary.org/obo/CHEBI_16995		3_STAR
OBO:MAXO_0000808	biolink:NamedThing	urine glucose measurement	A measurement of the amount of sugar (glucose) in a urine sample.		hp.json	urine glucose testing|urine glucose assessment|urine glucose monitoring	http://purl.obolibrary.org/obo/MAXO_0000808		
OBO:MAXO_0000809	biolink:NamedThing	syphilis screening	Testing for sexually transmitted disease syphilis. Syphilis is a contagious bacterial infection caused by the spirochete Treponema pallidum.		hp.json	syphylis testing	http://purl.obolibrary.org/obo/MAXO_0000809		
HP:0011513	biolink:PhenotypicFeature	Retinal cavernous angioma	A benign tumor of the retina that appears as a grouping of blood-filled saccules within the inner retinal layers or on the surface of the optic disc. Retinal cavernous angioma are described as having a 'cluster of grapes' appearance.	SNOMEDCT_US:312937006|UMLS:C0730304	hp.json		http://purl.obolibrary.org/obo/HP_0011513		
HP:0011514	biolink:PhenotypicFeature	Abnormality of binocular vision	An abnormality of binocular vision, that is of the ability to synthesize the visual inputs from both eyes to a single image with perception of depth.	UMLS:C4023320	hp.json		http://purl.obolibrary.org/obo/HP_0011514		
HP:0011515	biolink:PhenotypicFeature	Abnormal stereopsis	Inability to make fine depth discriminations from parallax provided by the two eyes' different positions on the head.	UMLS:C4023319	hp.json		http://purl.obolibrary.org/obo/HP_0011515		
HP:0011516	biolink:PhenotypicFeature	Achromatopsia	A condition where the retina contains no functional cone cells, so that in addition to the absence of color discrimination, vision in lights of normal intensity is difficult.	SNOMEDCT_US:102450007|MSH:C536021|UMLS:C0302129	hp.json	Rod monochromacy|Rod monochromatism	http://purl.obolibrary.org/obo/HP_0011516		
HP:0011517	biolink:PhenotypicFeature	Cone monochromacy	The condition of having both rods and cones, but only a single kind of cone. Affected individuals have good pattern vision in daylight, but cannot distinguish between colors.	UMLS:C4023318	hp.json		http://purl.obolibrary.org/obo/HP_0011517		
CHEBI:16990	biolink:ChemicalSubstance	bilirubin IXalpha	A member of the class of  biladienes that is a linear tetrapyrrole with the dipyrrole units being of both exovinyl and endovinyl type. A product of heme degradation, it is produced in the reticuloendothelial system by the reduction of biliverdin and transported to the liver as a complex with serum albumin.	KNApSAcK:C00029828|PMID:18442622|PMID:23768684|HMDB:HMDB0000054|PMID:23763371|Gmelin:411033|PMID:9587403|PDBeChem:BLR|CAS:635-65-4|CAS:635-65-4|KEGG:C00486|PMID:8605219|MetaCyc:BILIRUBIN|Wikipedia:Bilirubin|Reaxys:74376|PMID:30224965|Beilstein:74376|PMID:12799017	hp.json	bilirubin-IXalpha|bilirubin|2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid|3,18-diethenyl-2,7,13,17-tetramethyl-1,19-dioxo-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoic acid|1,10,19,22,23,24-hexahydro-2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinylbiline-8,12-dipropionic acid|bilirubin(Z,Z)|8,12-bis(2-carboxyethyl)-2,7,13,17-tetramethyl-3,18-divinylbiladiene-ac-1,19(21H,24H)-dione|Bilirubin|2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropanoic acid	http://purl.obolibrary.org/obo/CHEBI_16990		3_STAR
HP:0011518	biolink:PhenotypicFeature	Dichromacy	Individuals affected by dichromacy possess only two types of cones, instead of three.	UMLS:C4023317	hp.json		http://purl.obolibrary.org/obo/HP_0011518		
HP:0011519	biolink:PhenotypicFeature	Anomalous trichromacy	Individuals with anomalous trichromacy possess three types of cones, but one of the three types of cones has an abnormal spectral sensitivity compared to normal cones.	UMLS:C4023316	hp.json		http://purl.obolibrary.org/obo/HP_0011519		
HP:0011500	biolink:PhenotypicFeature	Polycoria	Multiple pupils.	SNOMEDCT_US:204159004|UMLS:C0344544	hp.json	Multiple pupils	http://purl.obolibrary.org/obo/HP_0011500		
HP:0011501	biolink:PhenotypicFeature	Anterior lenticonus	A conical projection of the anterior surface of the lens, occurring as a developmental anomaly.	UMLS:C0344262|SNOMEDCT_US:95480008	hp.json		http://purl.obolibrary.org/obo/HP_0011501		
GO:0097186	biolink:BiologicalProcess	amelogenesis	The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.		hp.json	enamel development	http://purl.obolibrary.org/obo/GO_0097186		
UBERON:0035350	biolink:AnatomicalEntity	branch of middle cerebral artery		FMA:50081|NCIT:C33114	hp.json	middle cerebral arterial branch	http://purl.obolibrary.org/obo/UBERON_0035350		
UBERON:0011320	biolink:AnatomicalEntity	ligament of temporomandibular joint		FMA:57070	hp.json	temporomandibular joint ligament	http://purl.obolibrary.org/obo/UBERON_0011320		
UBERON:0011322	biolink:AnatomicalEntity	mylohyoid nerve	A nerve that innervates the mylohyoid muscle and the anterior belly of the digastric muscle.	FMA:53247|BAMS:myhy	hp.json	mylohyoid branch of inferior alveolar nerve|nerve to mylohyoid|nervus mylohyoideus|branch of inferior alveolar nerve to mylohyoid|nerve to mylohyoid|nervus mylohyoideus|mylodigastric nerve	http://purl.obolibrary.org/obo/UBERON_0011322		
UBERON:0011321	biolink:AnatomicalEntity	masseteric nerve	A muscular branch of the mandibular nerve passing to the medial surface of the masseter muscle, which it innervates.	FMA:53103	hp.json	nervus massetericus	http://purl.obolibrary.org/obo/UBERON_0011321		
UBERON:0011314	biolink:AnatomicalEntity	anterior subdivision of masseter			hp.json	masseter, anterior	http://purl.obolibrary.org/obo/UBERON_0011314		
UBERON:0011318	biolink:AnatomicalEntity	capsule of temporomandibular joint	The articular capsule (capsular ligament) is a thin, loose envelope, attached above to the circumference of the mandibular fossa and the articular tubercle immediately in front; below, to the neck of the condyle of the mandible.	MFMO:0000046|FMA:57050	hp.json	capsula articularis articulationis temporomandibularis|articular capsule of temporomandibular joint	http://purl.obolibrary.org/obo/UBERON_0011318		
HP:0011502	biolink:PhenotypicFeature	Posterior lenticonus	A conical projection of the posterior surface of the lens, occurring as a developmental anomaly.	UMLS:C0344263|SNOMEDCT_US:95482000	hp.json		http://purl.obolibrary.org/obo/HP_0011502		
HP:0011503	biolink:PhenotypicFeature	Aplasia of the fovea	Congenital absence of the fovea.	UMLS:C4023324	hp.json	Absent fovea	http://purl.obolibrary.org/obo/HP_0011503		
HP:0011504	biolink:PhenotypicFeature	Bull's eye maculopathy	Progressive maculopathy characterized by concentric regions of hyper- and hypo-pigmentation.	MSH:C537833|UMLS:C0730330|SNOMEDCT_US:312958000|SNOMEDCT_US:424169002|UMLS:C1828210	hp.json	Chloroquine retinopathy	http://purl.obolibrary.org/obo/HP_0011504		
CHEBI:14321	biolink:ChemicalSubstance	glutamate(1-)	An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group	Gmelin:327908	hp.json	hydrogen glutamate|glutamate|glutamate(1-)|glutamic acid monoanion|2-ammoniopentanedioate	http://purl.obolibrary.org/obo/CHEBI_14321		3_STAR
HP:0011505	biolink:PhenotypicFeature	Cystoid macular edema	Cystoid macular edema (CME) is any type of macular edema that involves cyst formation.	SNOMEDCT_US:193387007|MSH:D008269|UMLS:C0024440	hp.json	Cystoid macular oedema	http://purl.obolibrary.org/obo/HP_0011505		
HP:0011506	biolink:PhenotypicFeature	Choroidal neovascularization	Choroidal neovascularization (CNV) is the creation of new blood vessels in the choroid layer of the eye.	UMLS:C4023323	hp.json	Choroidal neovascular membrane	http://purl.obolibrary.org/obo/HP_0011506		
HP:0011507	biolink:PhenotypicFeature	Macular flecks	Pale often indistinct lesions of the macula.	UMLS:C4023322	hp.json		http://purl.obolibrary.org/obo/HP_0011507		
HP:0011508	biolink:PhenotypicFeature	Macular hole	A macular hole is a small break in the macula, located in the center of the retina.	SNOMEDCT_US:232006002|UMLS:C0024441|MSH:D012167	hp.json		http://purl.obolibrary.org/obo/HP_0011508		
HP:0011509	biolink:PhenotypicFeature	Macular hyperpigmentation	Increased amount of pigmentation in the macula lutea.	UMLS:C0745109	hp.json		http://purl.obolibrary.org/obo/HP_0011509		
HP:0011571	biolink:PhenotypicFeature	Parachute mitral valve	Abnormality of the mitral valve apparatus, whereby chordae attach to a single papillary muscle or hypoplastic papillary muscles.	UMLS:C0546965|SNOMEDCT_US:204362007	hp.json		http://purl.obolibrary.org/obo/HP_0011571		
HP:0011572	biolink:PhenotypicFeature	Supramitral ring	A congenital stenotic mitral valvular anomaly with a ring of tissue above the mitral valve.	UMLS:C4021142	hp.json	Membranous supravalvular mitral stenosis|Supravalvular mitral ring	http://purl.obolibrary.org/obo/HP_0011572		
HP:0011573	biolink:PhenotypicFeature	Hypoplastic tricuspid valve	Congenital defect characterized by underdevelopment of the tricuspid valve.	UMLS:C4023294|Fyler:1720	hp.json	Underdeveloped tricuspid valve|Tricuspid valve hypoplasia	http://purl.obolibrary.org/obo/HP_0011573		
HP:0011574	biolink:PhenotypicFeature	Imperforate atrioventricular valve	An atrioventricular valve that has failed to open (atretic).	UMLS:C4023293	hp.json	Unopened atrioventricular valve	http://purl.obolibrary.org/obo/HP_0011574		
HP:0011575	biolink:PhenotypicFeature	Imperforate tricuspid valve	A tricuspid valve that has failed to open.	UMLS:C4023292	hp.json	Unopened tricuspid valve	http://purl.obolibrary.org/obo/HP_0011575		
HP:0011576	biolink:PhenotypicFeature	Intermediate atrioventricular canal defect	A specific combination of heart defects with a primum atrial septal defect, cleft anterior mitral valve leaflet, and inlet ventricular defect. There is one valve annulus and two valve orifices.	UMLS:C4023291|Fyler:1121	hp.json	Intermediate atrioventricular septal defect	http://purl.obolibrary.org/obo/HP_0011576		
HP:0011577	biolink:PhenotypicFeature	Partial atrioventricular canal defect	A specific combination of heart defects including a primum atrial septal defect and cleft anterior mitral valve leaflet. There is not an inlet ventricular septal defect present. There are two valve annuluses and two valve orifices.	SNOMEDCT_US:718216009|UMLS:C4023290	hp.json		http://purl.obolibrary.org/obo/HP_0011577		
UBERON:0011391	biolink:AnatomicalEntity	perineal nerve	A nerve arising from the pudendal nerve that supplies the perineum.	FMA:21866	hp.json	perineal branch of pudendal nerve	http://purl.obolibrary.org/obo/UBERON_0011391		
UBERON:0011390	biolink:AnatomicalEntity	pudendal nerve	The pudendal nerve is a somatic nerve in the pelvic region that innervates the external genitalia of both sexes, as well as sphincters for the bladder and the rectum. It originates in Onuf's nucleus in the sacral region of the spinal cord.	FMA:19037|MESH:D060525	hp.json	nervus pudendales|internal pudendal nerve|pudendal|nervus pudendae|nervus pudendae|pudenal nerve	http://purl.obolibrary.org/obo/UBERON_0011390		human_reference_atlas
HP:0011578	biolink:PhenotypicFeature	Transitional atrioventricular canal defect	A specific combination of heart defects with a primum atrial septal defect, cleft anterior mitral valve leaflet, and an inlet ventricular septal defect. There are two valve annuli and two valve orifices.	UMLS:C4023289	hp.json		http://purl.obolibrary.org/obo/HP_0011578		
HP:0011570	biolink:PhenotypicFeature	Congenital mitral stenosis	Mitral stenosis with congenital onset.	UMLS:C0158618|SNOMEDCT_US:82458004	hp.json		http://purl.obolibrary.org/obo/HP_0011570		
HP:0011579	biolink:PhenotypicFeature	Unbalanced atrioventricular canal defect	Anatomic features of unbalanced atrioventricular septal defect (AVSD) include varying amounts of ventricular hypoplasia, as well as malalignment of the atrioventricular junction. In complete AVSD, the common AV valve can be situated either equally over the right and left ventricles (balanced) or unequally over the ventricles (unbalanced).	UMLS:C3280940	hp.json	Unbalanced atrioventricular septal defect	http://purl.obolibrary.org/obo/HP_0011579		
HP:0011560	biolink:PhenotypicFeature	Mitral atresia	A congenital defect with failure to open of the mitral valve orifice.	UMLS:C0344760|Fyler:0310|EPCC:06.02.01|SNOMEDCT_US:23063005|ICD-10:Q23.2|Fyler:310	hp.json	Mitral valve atresia	http://purl.obolibrary.org/obo/HP_0011560		
HP:0011561	biolink:PhenotypicFeature	Overriding atrioventricular valve	An atrioventricular valve that empties into both ventricles. The valve overrides the interventricular septum above a ventricular septum defect.	UMLS:C4023298	hp.json		http://purl.obolibrary.org/obo/HP_0011561		
HP:0011562	biolink:PhenotypicFeature	Straddling atrioventricular valve	Anomalous insertion of the chordae tendinae or papillary muscles into the contralateral ventricle in the presence of a ventricular septum defect.	UMLS:C4023297	hp.json		http://purl.obolibrary.org/obo/HP_0011562		
HP:0011563	biolink:PhenotypicFeature	Abnormal ventriculoarterial connection	An abnormality of the circulatory connection between the ventricles and the pulmonary artery and aorta.	UMLS:C4023296	hp.json	Abnormal ventriculoarterial connexion|Abnormal ventriculo-arterial connection	http://purl.obolibrary.org/obo/HP_0011563		
HP:0011564	biolink:PhenotypicFeature	Mitral valve arcade	Anomalous mitral valve arcade is diagnosed based on the following features (1) An adequately sized mitral valve orifice; (2) short, thick, and poorly differentiated chordae with direct union of the papillary muscles to the anterior leaflet; (3) narrow or nearly nonexistent spaces between the abnormal chordae; and (4) greater differentiation of the chordae attached to the posterior papillary muscle.	UMLS:C4021143	hp.json	Hammock mitral valve	http://purl.obolibrary.org/obo/HP_0011564		
HP:0011565	biolink:PhenotypicFeature	Common atrium	Complete absence of the interatrial septum with common atrioventricular valve and two atrioventricular connections.	ICD-10:Q21.2|UMLS:C0392482|Fyler:1140|SNOMEDCT_US:253276007	hp.json	Single atrium	http://purl.obolibrary.org/obo/HP_0011565		
HP:0011566	biolink:PhenotypicFeature	Cor triatriatum dexter	A congenital anomaly with partitioning of the right atrium to form a triatrial heart caused by persistence of the right valve of the sinus venosus. Typically, the right atrial partition is due to exaggerated fetal eustachian and thebesian valves, which together form an incomplete septum across the lower part of the atrium. This septum may range from a reticulum to a substantial sheet of tissue.	Fyler:2854|UMLS:C0344697|SNOMEDCT_US:274947007	hp.json	Cor triatriatum dextrum	http://purl.obolibrary.org/obo/HP_0011566		
UBERON:0011380	biolink:AnatomicalEntity	female external urethral sphincter	The external sphincter muscle of female urethra is a muscle which controls urination.	FMA:19778	hp.json	musculus sphincter urethrae externus urethrae femininae|compressor urethrae|rhabdosphincter of female urethra|musculus sphincter urethrae externus (urethra feminina)|striated muscle layer of female urethra|outer muscle layer of female urethra|urethrovaginal sphincter|sphincter urethrovaginalis|external urethral sphincter of female urethra	http://purl.obolibrary.org/obo/UBERON_0011380		
HP:0011567	biolink:PhenotypicFeature	Sinus venosus atrial septal defect	An interatrial communication caused by a deficiency of the common wall between the superior vena cava (SVC) and the right-sided pulmonary veins. SVASD is commonly associated with anomalous pulmonary venous connection (APVC) of some or all of the pulmonary veins, which produces additional left-to-right shunting.	SNOMEDCT_US:95268002|MSH:C548009|ICD-10:Q21.1|UMLS:C0344730|Fyler:2010	hp.json		http://purl.obolibrary.org/obo/HP_0011567		
UBERON:0011386	biolink:AnatomicalEntity	facial modiolus	A chiasma of facial muscles held together by fibrous tissue, located lateral and slightly superior to each angle of the mouth. It is important in moving the mouth, facial expression and in dentistry. It derives its motor nerve supply from the facial nerve, and its blood supply from labial branches of the facial artery. It is contributed to by the following muscles: orbicularis oris, buccinator, levator anguli oris, depressor anguli oris, zygomaticus major, risorius quadratus labii superioris, quadratus labii inferioris.	MFMO:0000057|FMA:46837	hp.json	modiolus|modiolus anguli oris	http://purl.obolibrary.org/obo/UBERON_0011386		
CHEBI:16924	biolink:ChemicalSubstance	5-oxo-D-proline	The D-enantiomer of 5-oxoproline.	Gmelin:1473408|DrugBank:DB03088|KEGG:C02237|PMID:22770225|MetaCyc:CPD-656|Reaxys:82133|Beilstein:82133|CAS:4042-36-8|CAS:4042-36-8|HMDB:HMDB0000267	hp.json	(2R)-5-oxopyrrolidine-2-carboxylic acid|D-5-Pyrrolidone-2-carboxylic acid|D-Pyroglutamic acid|5-oxo-D-proline|5-Oxo-D-proline	http://purl.obolibrary.org/obo/CHEBI_16924		3_STAR
GO:0120025	biolink:CellularComponent	plasma membrane bounded cell projection	A prolongation or process extending from a cell and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.		hp.json		http://purl.obolibrary.org/obo/GO_0120025		
GO:0120023	biolink:MolecularActivity	somatostatin binding	Binding to somatostatin, a polypeptide hormone involved in regulating pancreatic alpha and pancreatic beta cells and controlling growth hormone secretion as well as many other functions. Somatostatin is produced by several cell types including pancreatic delta cells. There are several different mature forms of somatostatin.		hp.json		http://purl.obolibrary.org/obo/GO_0120023		
HP:0011568	biolink:PhenotypicFeature	Double orifice mitral valve	The left atrio-ventricular connection consists of two anatomically distinct orifices separated by accessory fibrous tissue.	SNOMEDCT_US:253402005|UMLS:C0344770	hp.json		http://purl.obolibrary.org/obo/HP_0011568		
HP:0011569	biolink:PhenotypicFeature	Cleft anterior mitral valve leaflet	Cleft in the anterior mitral valve leaflet not associated with an atrioventricular canal defect.	UMLS:C4023295	hp.json		http://purl.obolibrary.org/obo/HP_0011569		
CHEBI:28938	biolink:ChemicalSubstance	ammonium	An onium cation obtained by protonation of ammonia.	PMID:19716251|PMID:17392693|Wikipedia:Ammonium|PMID:11341317|PMID:18515490|PDBeChem:NH4|Gmelin:84|MetaCyc:AMMONIUM|CAS:14798-03-9|PMID:22524020|MolBase:929|Reaxys:16093784|PMID:22265469|PMID:11319011|PMID:19199063|PMID:16903292|PMID:22631217|KEGG:C01342|CAS:14798-03-9|PMID:19682559|PMID:14512268|PMID:12096804|PMID:22562341|PMID:14879753|PMID:21993530|PMID:16345391|PMID:19596600	hp.json	Ammonium(1+)|azanium|NH4(+)|NH4(+)|ammonium ion|NH4+|ammonium|ammonium cation|[NH4](+)|ammonium	http://purl.obolibrary.org/obo/CHEBI_28938		3_STAR
CHEBI:77941	biolink:ChemicalSubstance	EC 3.5.1.4 (amidase) inhibitor	An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4).	Wikipedia:Amidase	hp.json	deaminase inhibitor|EC 3.5.1.4 inhibitor|amidohydrolase inhibitors|amidohydrolase inhibitor|EC 3.5.1.4 inhibitors|deaminase inhibitors|N-acetylaminohydrolase inhibitor|amidase inhibitor|amidase (EC 3.5.1.4) inhibitors|fatty acylamidase inhibitors|EC 3.5.1.4 (amidase) inhibitors|acylamide amidohydrolase inhibitors|acylamidase inhibitors|acylamidase inhibitor|acylamide amidohydrolase inhibitor|fatty acylamidase inhibitor|amidase (EC 3.5.1.4) inhibitor|N-acetylaminohydrolase inhibitors|amidase inhibitors	http://purl.obolibrary.org/obo/CHEBI_77941		3_STAR
HP:0011550	biolink:PhenotypicFeature	Biventricular heart with straddling right sided atrioventricular valve and absent left sided atrioventricular connection		UMLS:C4023304	hp.json		http://purl.obolibrary.org/obo/HP_0011550		
HP:0011551	biolink:PhenotypicFeature	Right sided atrium to left ventricle and absent left sided atrioventricular connection		UMLS:C4023303	hp.json	Right sided atrium to left ventricle and absent left sided atrioventricular connexion	http://purl.obolibrary.org/obo/HP_0011551		
HP:0011552	biolink:PhenotypicFeature	Ambiguous atrioventricular connection	With left or right cardiac isomerism in a biventricular, the atrioventricular connections are perforce ambiguous, in that one of the connections is concordant (e.g., right-sided morphologic right atrium connected to a morphologic right ventricle) and one of the connections is discordant (e.g., left-sided morphologic right atrium connected to a morphologic left ventricle).	SNOMEDCT_US:253278008|UMLS:C0344617	hp.json	Ambiguous atrioventricular connexion	http://purl.obolibrary.org/obo/HP_0011552		
HP:0011553	biolink:PhenotypicFeature	Discordant atrioventricular connection	Connection of the right atrium to the left ventricle and of the left atrium to the right ventricle in a biventricular heart.	UMLS:C0344615|SNOMEDCT_US:253277003	hp.json	Discordant atrioventricular connexion	http://purl.obolibrary.org/obo/HP_0011553		
UBERON:0011371	biolink:AnatomicalEntity	sternocephalicus muscle	The sternocephalicus is a flat muscle and its caudal border is adjacent to the ventral border of the brachiocephalicus. The lateral aspect of this muscle is crossed obliquely by the external jugular vein. It originates as a unit on the first sternebrae. The cranial portion of the muscle divides into two separate sections with different insertion points. These are the sternomastoideus and the sterno-occipitalis. The ventral portion, the sternomastiodeus is the stronger and main continuation of the sternocephalicus, which inserts on the mastoid part of the temporal bone. The thin but wide dorsal segment, the sterno-occipitalis attaches to the dorsal nuchal crest by a thin aponeurosis. The main action provided by the sternocephalicus is movement of the head and neck to the side. Ventral branches of the cervical nerves are attached to this muscle.	NCIT:C117980	hp.json	sternocephalicus	http://purl.obolibrary.org/obo/UBERON_0011371		
HP:0011554	biolink:PhenotypicFeature	Double inlet atrioventricular connection	The condition in which both atria are joined to a single ventricle each by its own atrioventricular valve.	UMLS:C4023302|ICD-10:Q20.4|EPCC:01.01.14	hp.json	Double inlet atrioventricular connexion	http://purl.obolibrary.org/obo/HP_0011554		
UBERON:0011370	biolink:AnatomicalEntity	transverse process of atlas	A transverse process of vertebra that is part of a vertebral bone 1.	FMA:23981	hp.json		http://purl.obolibrary.org/obo/UBERON_0011370		
HP:0011555	biolink:PhenotypicFeature	Double inlet left ventricle	The condition in which both atria are joined to the left ventricle each by its own atrioventricular valve. Usually there is a hypoplastic right ventricle, which may be on the opposite side of the heart as usual.	EPCC:01.04.04|ICD-10:Q20.4|SNOMEDCT_US:253283000|UMLS:C0344622	hp.json		http://purl.obolibrary.org/obo/HP_0011555		
OBO:uberon/core#proximally_connected_to	biolink:NamedThing	proximally connected to	x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y.		hp.json		http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to		
HP:0011556	biolink:PhenotypicFeature	Double inlet right ventricle	The condition in which both atria are joined to the right ventricle each by its own atrioventricular valve. Usually, the left ventricle is hypoplastic.	EPCC:01.04.03|ICD-10:Q20.4|UMLS:C0344621|SNOMEDCT_US:253282005	hp.json		http://purl.obolibrary.org/obo/HP_0011556		
UBERON:0011375	biolink:AnatomicalEntity	skin of prepuce of clitoris	A zone of skin that is part of a prepuce of clitoris.	FMA:27886	hp.json	preputial skin of clitoris	http://purl.obolibrary.org/obo/UBERON_0011375		
UBERON:0011374	biolink:AnatomicalEntity	prepuce	A retractable double-layered fold of skin and mucous membrane that covers the glans penis or clitoris. Glands may also be present.	NCIT:C12323	hp.json		http://purl.obolibrary.org/obo/UBERON_0011374		
UBERON:0011379	biolink:AnatomicalEntity	male external urethral sphincter	The external sphincter muscle of urethra (or sphincter urethrae membranaceae) surrounds the whole length of the membranous portion of the urethra, and is enclosed in the fasciæ of the urogenital diaphragm. They arch across the front of the urethra and bulbourethral glands, pass around the urethra, and behind it unite with the muscle of the opposite side, by means of a tendinous raphé.	MA:0002273|FMA:19733|UMLS:C1707060|NCIT:C52891	hp.json	external urethral sphincter of male urethra|bulboglandular muscle|male sphincter urethrae muscle|male sphincter urethrae|male urethral sphincter muscle|musculus sphincter urethrae externus urethrae masculinae|musculus sphincter urethrae externus (urethra masculina)|bulboglandular|musculus sphincter urethrae membranaceae	http://purl.obolibrary.org/obo/UBERON_0011379		
GO:0120039	biolink:BiologicalProcess	plasma membrane bounded cell projection morphogenesis	The process in which the anatomical structures of a plasma membrane bounded cell projection are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0120039		
GO:0120035	biolink:BiologicalProcess	regulation of plasma membrane bounded cell projection organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.		hp.json		http://purl.obolibrary.org/obo/GO_0120035		
CHEBI:16958	biolink:ChemicalSubstance	beta-alanine	A naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position.	PMID:18528519|KNApSAcK:C00001333|PMID:12887142|CAS:107-95-9|PMID:20994958|CAS:107-95-9|PMID:19955842|PMID:14363188|Wikipedia:Beta-Alanine|PMID:12107759|KEGG:C00099|PMID:11850512|PMID:20479615|MetaCyc:B-ALANINE|PMID:18613640|Gmelin:49614|DrugBank:DB03107|PMID:20199122|HMDB:HMDB0000056|PDBeChem:BAL|PMID:19239140|PMID:20386120|Beilstein:906793|PMID:11139233|KEGG:D07561|PMID:22735334|CAS:107-95-9|PMID:16934791|Reaxys:906793	hp.json	beta-alanine|3-aminopropanoic acid|3-Aminopropionic acid|3-aminopropanoic acid|H-beta-Ala-OH|beta-Alanine|beta-aminopropionic acid|bAla|BETA-ALANINE|omega-aminopropionic acid	http://purl.obolibrary.org/obo/CHEBI_16958		3_STAR
GO:0120036	biolink:BiologicalProcess	plasma membrane bounded cell projection organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasma membrane bounded prolongation or process extending from a cell, e.g. a cilium or axon.		hp.json		http://purl.obolibrary.org/obo/GO_0120036		
GO:0120031	biolink:BiologicalProcess	plasma membrane bounded cell projection assembly	Formation of a prolongation or process extending and that is bounded by plasma membrane, e.g. a cilium, lamellipodium, or axon.		hp.json	eupodium	http://purl.obolibrary.org/obo/GO_0120031		
GO:0120032	biolink:BiologicalProcess	regulation of plasma membrane bounded cell projection assembly	Any process that modulates the rate, frequency, or extent of plasma membrane bounded cell projection assembly.		hp.json		http://purl.obolibrary.org/obo/GO_0120032		
GO:0120033	biolink:BiologicalProcess	negative regulation of plasma membrane bounded cell projection assembly	Any process that stops, prevents or reduces the frequency, rate or extent of plasma membrane bounded cell projection assembly.		hp.json		http://purl.obolibrary.org/obo/GO_0120033		
GO:0120034	biolink:BiologicalProcess	positive regulation of plasma membrane bounded cell projection assembly	Any process that activates or increases the frequency, rate or extent of plasma membrane bounded cell projection assembly.		hp.json		http://purl.obolibrary.org/obo/GO_0120034		
HP:0011557	biolink:PhenotypicFeature	Double inlet to single ventricle of indeterminate morphology	The condition in which both atria are joined to a single ventricle each by its own atrioventricular valve. The morphology of this ventricle does not allow one to determine if it corresponds to the left or right ventricle.	UMLS:C4023301	hp.json		http://purl.obolibrary.org/obo/HP_0011557		
HP:0011558	biolink:PhenotypicFeature	Double inlet to single ventricle with common atrioventricular orifice		UMLS:C4023300	hp.json		http://purl.obolibrary.org/obo/HP_0011558		
HP:0011559	biolink:PhenotypicFeature	Double inlet to single ventricle with two atrioventricular valves		UMLS:C4023299	hp.json		http://purl.obolibrary.org/obo/HP_0011559		
CHEBI:77968	biolink:ChemicalSubstance	humectant	A compound that is used to keep a substance moist.	Wikipedia:humectant	hp.json	humectants	http://purl.obolibrary.org/obo/CHEBI_77968		3_STAR
HP:0011540	biolink:PhenotypicFeature	Congenitally corrected transposition of the great arteries	The essence of the lesion is the combination of discordant atrioventricular and ventriculo-arterial connections. Thus, the morphologically right atrium is connected to a morphologically left ventricle across the mitral valve, with the left ventricle then connected to the pulmonary trunk. The morphologically left atrium is connected to the morphologically right ventricle across the tricuspid valve, with the morphologically right ventricle connected to the aorta.	SNOMEDCT_US:56743000|UMLS:C0344616|ICD-10:Q20.5|MSH:C535426|UMLS:C0232301|SNOMEDCT_US:83799000|EPCC:01.01.03	hp.json	Ventricular inversion|L-transposition	http://purl.obolibrary.org/obo/HP_0011540		
HP:0011541	biolink:PhenotypicFeature	Criss-cross atrioventricular valves	Crossing of the inflow streams of the two ventricles, due to an apparent twisting of the heart about its long axis.	UMLS:C4023310	hp.json		http://purl.obolibrary.org/obo/HP_0011541		
HP:0011542	biolink:PhenotypicFeature	Criss-cross atrioventricular valves with superior-inferior ventricles	Criss-cross atrioventricular valves with a rare cardiac malformation characterized by the two ventricles lying one above the other instead of side by side.	UMLS:C4023309	hp.json		http://purl.obolibrary.org/obo/HP_0011542		
HP:0011543	biolink:PhenotypicFeature	Superior-inferior ventricles without criss-cross atrioventricular valves		Fyler:0184|Fyler:184|UMLS:C4023308	hp.json		http://purl.obolibrary.org/obo/HP_0011543		
HP:0011544	biolink:PhenotypicFeature	L-looping of the right ventricle		UMLS:C4023307	hp.json		http://purl.obolibrary.org/obo/HP_0011544		
HP:0011545	biolink:PhenotypicFeature	Abnormal connection of the cardiac segments	A deviance in the normal connections between two cardiac segements.	UMLS:C4023306	hp.json	Discordant connection of the cardiac segments|Abnormal connexion of the cardiac segments	http://purl.obolibrary.org/obo/HP_0011545		
CHEBI:77969	biolink:ChemicalSubstance	food humectant	A humectant that is used as a food additive to prevent foodstuffs from drying out.		hp.json	food humectants	http://purl.obolibrary.org/obo/CHEBI_77969		3_STAR
UBERON:0011364	biolink:AnatomicalEntity	cleidocephalicus muscle	The cleidomastoideus is a thick, strap-like muscle that together with the cleidocervicalis forms the proximal part of the brachiocephalicus. It lies beneath the cleidocervicalis. Its origin is the clavicular tendon with its insertion being at the mastoid process of the temporal bone. It is distinctly narrow and is united with the cleidocervicalis and cleidobrachialis by the clavicular tendon. Together with the other two components of the brachiocephalicus muscle, its primary function is to advance the free limb, however, it can also act as an shoulder extensor. Acting bilaterally, it fixes and depresses the neck, while by its unilateral action, it allows the head and neck to be drawn to the side. Its blood supply is the inferior cervical, carotid and vertebral arteries and its nerve supply is the spinal accessory, cervical and axillary nerves.	EMAPA:37687|UMLS:C1707412|NCIT:C52893|MA:0002275	hp.json	cleidomastoid|pars mastoideus|cleidocephalicus|cleidomastoideus|cleidocephalic|cleidomastoid muscle|cleidocephalic muscle	http://purl.obolibrary.org/obo/UBERON_0011364		
UBERON:0011363	biolink:AnatomicalEntity	cranial lymph vasculature	A lymph vasculature that is part of a head.	ZFA:0005298|TAO:0005298|FMA:224562	hp.json	set of lymphatic vessels of head|cranial lymphatics|cranial lymph vessel|set of cranial lymphatic vessels|cranial lymph vessels	http://purl.obolibrary.org/obo/UBERON_0011363		
UBERON:0011362	biolink:AnatomicalEntity	cranial blood vasculature	A blood vasculature that is part of a head.	ZFA:0005297|TAO:0005297	hp.json	set of blood vessels of head|cranial blood vessel|cranial blood vessels	http://purl.obolibrary.org/obo/UBERON_0011362		
UBERON:0035313	biolink:AnatomicalEntity	posterior wall of laryngopharynx		NCIT:C12249|FMA:55063	hp.json	posterior wall of hypopharynx	http://purl.obolibrary.org/obo/UBERON_0035313		
UBERON:0011368	biolink:AnatomicalEntity	brachiocephalic muscle	The brachiocephalicus is a long and flat, complex of muscles that extends from the lower half of the humeral shaft to the head and neck. The muscle divides into two parts at the clavicular intersection. This is also the point of origin for all the muscles that make up the brachiocephalicus. This point is situated just cranial to the shoulder. The two main sections are the cleidobrachialis which is distal to the clavicular intersection and the cleidocephalicus which extends proximally to the clavivular intersection. The cleidocephalicus can also be divided into the pars cervicalis, which inserts on the broad aponeurosis, over the fibrous raphe of the cranial half of the neck. The other part, the pars mastoideus inserts on the mastoid process of the temporal bone via a strong tendon. The cleidobrachialis extends distally from the clavicular intersection and inserts on the cranial edge of the distal half of the humerus. The tendon that inserts the cleidobrachialis lies between the brachialis muscle and the biceps brachii. As a result of the brachiocephalicus spanning a large region it has the ability to provide a number of actions. These include extending the shoulder joint, protracts the limb, provides lateral movement of the head and allows the neck to be depressed.	EMAPA:37685	hp.json	brachiocephalicus	http://purl.obolibrary.org/obo/UBERON_0011368		
UBERON:0011366	biolink:AnatomicalEntity	cleidobrachialis muscle	This muscle makes up the distal segment of the brachiocephalicus. It originates at the clavicular tendon but functionally, from the head and neck through the cleidocervicalis. It inserts at the distal end of the cranial border of the humerus, where it lies between the biceps brachii medially and the brachialis laterally. The muscle partly covers the pectoral muscles at their insertions. In conjunction with the cleidocervicalis, it advances the limb, extends the shoulder and causes lateral movement of the head and neck.	MA:0002274|EMAPA:37686|UMLS:C1707411|NCIT:C52892	hp.json	cleidobrachial|cleidobrachialis|cleidobrachial muscle	http://purl.obolibrary.org/obo/UBERON_0011366		
CHEBI:16947	biolink:ChemicalSubstance	citrate(3-)	A tricarboxylic acid trianion, obtained by deprotonation of the three carboxy groups of citric acid.	CAS:126-44-3|Beilstein:1884707|Reaxys:1884707|KEGG:C00158|Gmelin:4239|PDBeChem:FLC	hp.json	cit|citrate|2-hydroxypropane-1,2,3-tricarboxylate|CITRATE ANION|2-hydroxy-1,2,3-propanetricarboxylate|2-hydroxy-1,2,3-propanetricarboxylate(3-)|cit(3-)|2-hydroxy-1,2,3-propanetricarboxylic acid, ion(3-)|2-hydroxytricarballylate	http://purl.obolibrary.org/obo/CHEBI_16947		3_STAR
UBERON:0035307	biolink:AnatomicalEntity	branch of vertebral artery		FMA:76259|NCIT:C33867	hp.json	vertebral arterial branch	http://purl.obolibrary.org/obo/UBERON_0035307		
HP:0011546	biolink:PhenotypicFeature	Abnormal atrioventricular connection	An abnormality of the circulatory connection between atria and ventricles.	SNOMEDCT_US:253274005|UMLS:C0344612	hp.json	Abnormal atrioventricular connexion	http://purl.obolibrary.org/obo/HP_0011546		
HP:0011547	biolink:PhenotypicFeature	Absent left sided atrioventricular connection	A defect where there is no connection between the left atrium and left ventricle.	UMLS:C0344629|SNOMEDCT_US:253290005	hp.json	Absent left sided atrioventricular connexion	http://purl.obolibrary.org/obo/HP_0011547		
HP:0011548	biolink:PhenotypicFeature	Absent right sided atrioventricular connection	A defect where there is no connection between the right atrium and right ventricle.	SNOMEDCT_US:253285007|UMLS:C0344624	hp.json	Absent right sided atrioventricular connexion	http://purl.obolibrary.org/obo/HP_0011548		
HP:0011549	biolink:PhenotypicFeature	Univentricular heart with absent left sided atrioventricular connection		UMLS:C4023305	hp.json	Univentricular heart with absent left sided atrioventricular connexion	http://purl.obolibrary.org/obo/HP_0011549		
UBERON:0001949	biolink:AnatomicalEntity	gingival epithelium	A stratified squamous epithelium consisting of a basal layer; it is keratinized or parakeratinized[BTO].	FMA:62423|BTO:0004998|UMLS:C1179154|MA:0001576|NCIT:C49239	hp.json	epithelium of gingiva|epithelial tissue of gingiva|gingiva epithelial tissue|gingiva epithelium	http://purl.obolibrary.org/obo/UBERON_0001949		
UBERON:0001948	biolink:AnatomicalEntity	regional part of spinal cord	A multi-tissue structure that is part of a spinal cord.	SCTID:244437008|NCIT:C33969|UMLS:C1268166|BIRNLEX:1496	hp.json	spinal cord part	http://purl.obolibrary.org/obo/UBERON_0001948		non_informative
UBERON:0001943	biolink:AnatomicalEntity	midbrain tegmentum	Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP].	MAT:0000452|ZFA:0000160|DHBA:12195|UMLS:C0039441|EHDAA2:0004475|XAO:0004271|VHOG:0001367|BTO:0003388|TAO:0000160|FMA:62393|BIRNLEX:1200|SCTID:362392007|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=491|EMAPA:18215|Wikipedia:Midbrain_tegmentum|MA:0000212|HBA:9002|EFO:0000921|BAMS:MTg	hp.json	tegmentum|tegmentum of midbrain|tegmentum mesencephali|tegmentum mesencephali|tegmentum mesencephalicum|MTg|mesencephalic tegmentum	http://purl.obolibrary.org/obo/UBERON_0001943		efo_slim|human_reference_atlas|uberon_slim|vertebrate_core|pheno_slim
CHEBI:26386	biolink:ChemicalSubstance	purine nucleobase	A nucleobase whose skeleton is derived from purine.	KEGG:C15587	hp.json	purine nucleobases|a purine nucleobase|purine bases|purine nucleobase	http://purl.obolibrary.org/obo/CHEBI_26386		3_STAR
GO:0014848	biolink:BiologicalProcess	urinary tract smooth muscle contraction	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra.		hp.json		http://purl.obolibrary.org/obo/GO_0014848		
UBERON:0001950	biolink:AnatomicalEntity	neocortex	An area of cerebral cortex defined on the basis of cytoarchitecture that have six layers. Starting from the cortical surface the layers are: molecular layer (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. It is composed of two subdivisions: true isocortex and proisocortex (Carpenter-83)(NN).	UMLS:C0175173|GAID:677|BAMS:ISO|FMA:62429|BAMS:Iso-cortex|MA:0002754|BAMS:NCX|PBA:294021746|BTO:0000920|MBA:315|EMAPA:32842|Wikipedia:Neocortex|MESH:D019579|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757|DHBA:10160|EHDAA2:0004662|EMAPA:35589|BIRNLEX:2547	hp.json	nonolfactory cortex|neocortex (isocortex)|isocortex (sensu lato)|homogenetic cortex|cerebral neocortex|iso-cortex|homotypical cortex|isocortex|neopallium|nucleus hypoglossalis|neopallial cortex	http://purl.obolibrary.org/obo/UBERON_0001950		uberon_slim|pheno_slim
UBERON:8410056	biolink:AnatomicalEntity	capillary of anorectum	A capillary that is part of the anorectum.		hp.json	blood vessel capillary of anorectum	http://purl.obolibrary.org/obo/UBERON_8410056		
UBERON:8410057	biolink:AnatomicalEntity	capillary of colon	A capillary that is part of the colon.		hp.json	blood vessel capillary of colon	http://purl.obolibrary.org/obo/UBERON_8410057		
OBO:uberon/core#transitively_connected_to	biolink:NamedThing	transitively_connected to			hp.json		http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to		
UBERON:0001951	biolink:AnatomicalEntity	epithelium of nasopharynx	An epithelium that is part of a nasopharynx [Automatically generated definition].	VHOG:0001038|NCIT:C49263|CALOHA:TS-0662|MA:0001865|EMAPA:17672|BTO:0004480|UMLS:C1179157|EHDAA:7090|FMA:62452|EHDAA2:0001241	hp.json	nasal part of pharynx epithelial tissue|nasopharyngeal epithelium|rhinopharynx epithelium|rhinopharynx epithelial tissue|nasal part of pharynx epithelium|nasopharynx epithelium|epithelial tissue of rhinopharynx|epithelial tissue of nasopharynx|epithelium of nasal part of pharynx|epithelium of rhinopharynx|epithelial tissue of nasal part of pharynx|nasopharynx epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0001951		
GO:0048199	biolink:BiologicalProcess	vesicle targeting, to, from or within Golgi	The process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.		hp.json	Golgi vesicle targeting|dictyosome vesicle targeting|vesicle targeting, to, from or within dictyosome	http://purl.obolibrary.org/obo/GO_0048199		
UBERON:8410050	biolink:AnatomicalEntity	anorectum	A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus.		hp.json	anorectal canal	http://purl.obolibrary.org/obo/UBERON_8410050		
UBERON:8410051	biolink:AnatomicalEntity	lymphatic vessel of colon	A lymphatic vessel located in the colon.		hp.json		http://purl.obolibrary.org/obo/UBERON_8410051		
GO:0048193	biolink:BiologicalProcess	Golgi vesicle transport	The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles.		hp.json	Golgi-derived vesicle transport	http://purl.obolibrary.org/obo/GO_0048193		goslim_yeast
GO:0097120	biolink:BiologicalProcess	receptor localization to synapse	Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.		hp.json	receptor localisation to synapse	http://purl.obolibrary.org/obo/GO_0097120		
GO:0014859	biolink:BiologicalProcess	negative regulation of skeletal muscle cell proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0014859		
GO:0014858	biolink:BiologicalProcess	positive regulation of skeletal muscle cell proliferation	Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0014858		
GO:0014857	biolink:BiologicalProcess	regulation of skeletal muscle cell proliferation	Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0014857		
GO:0061154	biolink:BiologicalProcess	endothelial tube morphogenesis	The process in which the anatomical structures of a tube are generated and organized from an endothelium. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.		hp.json		http://purl.obolibrary.org/obo/GO_0061154		
GO:0061155	biolink:BiologicalProcess	pulmonary artery endothelial tube morphogenesis	The process in which the anatomical structures of a tube are generated and organized from the pulmonary artery endothelium. An pulmonary artery endothelium is an epithelium that lines the pulmonary artery.		hp.json		http://purl.obolibrary.org/obo/GO_0061155		
GO:0061156	biolink:BiologicalProcess	pulmonary artery morphogenesis	The process in which the anatomical structures of the pulmonary artery are generated and organized. The pulmonary artery is the artery that carries blood from the heart to the lungs.		hp.json		http://purl.obolibrary.org/obo/GO_0061156		
GO:0014856	biolink:BiologicalProcess	skeletal muscle cell proliferation	The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0014856		
GO:0014855	biolink:BiologicalProcess	striated muscle cell proliferation	The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.		hp.json		http://purl.obolibrary.org/obo/GO_0014855		
UBERON:8410048	biolink:AnatomicalEntity	venule of colon	A venule located in the colon.		hp.json		http://purl.obolibrary.org/obo/UBERON_8410048		
UBERON:8410041	biolink:AnatomicalEntity	venule of lymph node	A venule that is part of a lymph node.		hp.json	lymph node venule	http://purl.obolibrary.org/obo/UBERON_8410041		human_reference_atlas
UBERON:8410042	biolink:AnatomicalEntity	arteriole of lymph node	An arteriole that is part of a lymph node.		hp.json	lymph node arteriole	http://purl.obolibrary.org/obo/UBERON_8410042		human_reference_atlas
UBERON:8410043	biolink:AnatomicalEntity	bronchus submucosal gland	A submucosal gland located in a bronchus.		hp.json	bronchial submucosal gland|airway submucosal gland|submucosal bronchial gland|submucosal bronchus gland	http://purl.obolibrary.org/obo/UBERON_8410043		
GO:0014827	biolink:BiologicalProcess	intestine smooth muscle contraction	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine.		hp.json		http://purl.obolibrary.org/obo/GO_0014827		
GO:0061181	biolink:BiologicalProcess	regulation of chondrocyte development	Any process that modulates the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.		hp.json		http://purl.obolibrary.org/obo/GO_0061181		
GO:0061182	biolink:BiologicalProcess	negative regulation of chondrocyte development	Any process that decreases the rate, frequency, or extent of the process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.		hp.json		http://purl.obolibrary.org/obo/GO_0061182		
GO:0061183	biolink:BiologicalProcess	regulation of dermatome development	Any process that modulates the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.		hp.json		http://purl.obolibrary.org/obo/GO_0061183		
GO:0061184	biolink:BiologicalProcess	positive regulation of dermatome development	Any process that increases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.		hp.json		http://purl.obolibrary.org/obo/GO_0061184		
GO:0061185	biolink:BiologicalProcess	negative regulation of dermatome development	Any process that decreases the rate, frequency, or extent of the progression of the dermatome over time, from its initial formation to the mature structure. The dermatome is the portion of a somite that will form skin.		hp.json		http://purl.obolibrary.org/obo/GO_0061185		
CHEBI:26361	biolink:ChemicalSubstance	protoporphyrins			hp.json		http://purl.obolibrary.org/obo/CHEBI_26361		1_STAR
GO:0061189	biolink:BiologicalProcess	positive regulation of sclerotome development	Any process that increases the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.		hp.json		http://purl.obolibrary.org/obo/GO_0061189		
GO:0014821	biolink:BiologicalProcess	phasic smooth muscle contraction	A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations.		hp.json		http://purl.obolibrary.org/obo/GO_0014821		
UBERON:8410034	biolink:AnatomicalEntity	lymph node artery	An artery that enters the lymph node at the hilum and branches into smaller arterioles.		hp.json	hilar artery of lymph node|artery of lymph node	http://purl.obolibrary.org/obo/UBERON_8410034		human_reference_atlas
UBERON:8410035	biolink:AnatomicalEntity	medullary arteriole of lymph node	An arteriole that arises from the hilar artery of a lymph node and radiates centrifugally, branching in the medulla.		hp.json	arteriole of medulla of lymph node	http://purl.obolibrary.org/obo/UBERON_8410035		human_reference_atlas
UBERON:8410036	biolink:AnatomicalEntity	medullary venule of lymph node	Medullary venules are a continuation of high endothelial venules which condense repeatedly in the interfollicular cortex and peripheral deep cortical unit and then transition to medullary venules at the corticomedullary junction. The medullary venules condense and return centripetally to the hilar vein.		hp.json	venule of medulla of lymph node	http://purl.obolibrary.org/obo/UBERON_8410036		human_reference_atlas
UBERON:0001913	biolink:AnatomicalEntity	milk	An emulsion of fat globules within a fluid that is secreted by the mammary gland during lactation.	EV:0100126|galen:Milk|MA:0002552|NCIT:C13401|ENVO:02000031|MAT:0000056|UMLS:C1511310|CALOHA:TS-0636|FMA:62100|MIAA:0000056|GAID:1230|MESH:D008892|OpenCyc:Mx4rvVjGZJwpEbGdrcN5Y29ycA|VHOG:0001263|EMAPA:36540|BTO:0000868	hp.json	mammary gland milk	http://purl.obolibrary.org/obo/UBERON_0001913		pheno_slim|uberon_slim
UBERON:0001916	biolink:AnatomicalEntity	endothelium of arteriole	An endothelium that is part of an arteriole [Automatically generated definition].	EMAPA:36286|NCIT:C49192|UMLS:C1179024|FMA:62115|MA:0000705	hp.json	arteriole endothelium	http://purl.obolibrary.org/obo/UBERON_0001916		
UBERON:0001915	biolink:AnatomicalEntity	endothelium of capillary	An endothelium that is part of a capillary [Automatically generated definition].	FMA:62114|EMAPA:36292|NCIT:C49215|BTO:0004954|MA:0000711|CALOHA:TS-0112|UMLS:C0006904	hp.json	blood capillary endothelium|capillary vessel endothelium|capillary endothelium|endothelium of capillary vessel|endothelium of blood capillary	http://purl.obolibrary.org/obo/UBERON_0001915		
UBERON:8410032	biolink:AnatomicalEntity	trabecular sinus of lymph node	The trabecular sinus is the lymph-filled space outside the trabeculae between lobules of the lymph node. This is a continuation of the subcapsular sinus which receives the afferent vessels and is present beneath the capsule. This space is traversed by both reticular fibers and cells in the lymph.		hp.json	lymph node trabecular sinus	http://purl.obolibrary.org/obo/UBERON_8410032		human_reference_atlas
UBERON:0001912	biolink:AnatomicalEntity	lobule of mammary gland	Organ component of the mammary gland which consists of an aggregate of mammary alveoli that communicate with a lobular lactiferous duct.[FMA].	FMA:62090|MA:0000793|EMAPA:36634	hp.json	lactiferous lobule|mammary acinus|lactiferous gland lobule|lobule of mammary gland|mammary gland lobule|acinus of mammary gland|lactiferous acinus|lobule of lactiferous gland	http://purl.obolibrary.org/obo/UBERON_0001912		pheno_slim|uberon_slim
UBERON:0001911	biolink:AnatomicalEntity	mammary gland	A specialized accessory gland of the skin of mammals that secretes milk. The gland is typically only developed in females, and regresses in males.	EFO:0000854|NCIT:C12367|EV:0100125|UMLS:C0929301|EMAPA:17759|MAT:0000073|OpenCyc:Mx4rvVjVq5wpEbGdrcN5Y29ycA|VHOG:0000398|FMA:286452|BTO:0000817|MESH:D008321|CALOHA:TS-0595|MIAA:0000073|MA:0000145	hp.json	lactiferous gland|glandula mammaria|glandula mammaria|mammae|dug|mamma|milk patch|lobe of breast|Brustdruese|lobe of mammary gland	http://purl.obolibrary.org/obo/UBERON_0001911		organ_slim|pheno_slim|efo_slim|uberon_slim
UBERON:8410033	biolink:AnatomicalEntity	lymph node vein	A vein where lymph node venules condense and which exits at the lymph node hilum. It is also called hilar vein.		hp.json	hilar vein of lymph node|vein of lymph node	http://purl.obolibrary.org/obo/UBERON_8410033		human_reference_atlas
CHEBI:26375	biolink:ChemicalSubstance	pterins			hp.json		http://purl.obolibrary.org/obo/CHEBI_26375		3_STAR
UBERON:0001918	biolink:AnatomicalEntity	endothelium of venule	An endothelium that is part of a venule [Automatically generated definition].	NCIT:C49319|FMA:62117|MA:0000716|EMAPA:36290|UMLS:C1179026	hp.json	venule endothelium	http://purl.obolibrary.org/obo/UBERON_0001918		
UBERON:0001917	biolink:AnatomicalEntity	endothelium of artery	An endothelium that is part of an artery [Automatically generated definition].	NCIT:C49194|FMA:62116|UMLS:C1179025|MA:0000707|BTO:0004757|AAO:0011013|VHOG:0001215|EMAPA:35148|XAO:0000357	hp.json	artery endothelium|arterial endothelium	http://purl.obolibrary.org/obo/UBERON_0001917		
UBERON:0001919	biolink:AnatomicalEntity	endothelium of vein	An endothelium that is part of a vein [Automatically generated definition].	EMAPA:36288|FMA:62118|NCIT:C49317|BTO:0004756|VHOG:0001216|AAO:0011110|XAO:0000358|MA:0000712|UMLS:C1179027	hp.json	venous endothelium|vein endothelium|veinous endothelium	http://purl.obolibrary.org/obo/UBERON_0001919		
CHEBI:26373	biolink:ChemicalSubstance	pteridines			hp.json		http://purl.obolibrary.org/obo/CHEBI_26373		3_STAR
GO:0014832	biolink:BiologicalProcess	urinary bladder smooth muscle contraction	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.		hp.json		http://purl.obolibrary.org/obo/GO_0014832		
GO:0014831	biolink:BiologicalProcess	gastro-intestinal system smooth muscle contraction	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract).		hp.json		http://purl.obolibrary.org/obo/GO_0014831		
UBERON:8410024	biolink:AnatomicalEntity	intestinal junction	An anatomical junction between two parts of the intestine.		hp.json	junction of intestine	http://purl.obolibrary.org/obo/UBERON_8410024		
GO:0002820	biolink:BiologicalProcess	negative regulation of adaptive immune response	Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.		hp.json	down regulation of adaptive immune response|inhibition of adaptive immune response|down-regulation of adaptive immune response|downregulation of adaptive immune response	http://purl.obolibrary.org/obo/GO_0002820		
GO:0002821	biolink:BiologicalProcess	positive regulation of adaptive immune response	Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.		hp.json	upregulation of adaptive immune response|stimulation of adaptive immune response|up regulation of adaptive immune response|up-regulation of adaptive immune response|activation of adaptive immune response	http://purl.obolibrary.org/obo/GO_0002821		
GO:0002822	biolink:BiologicalProcess	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.		hp.json		http://purl.obolibrary.org/obo/GO_0002822		
UBERON:0001987	biolink:AnatomicalEntity	placenta	Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell.	VHOG:0001266|UMLS:C0032043|GAID:379|EV:0100119|MESH:D010920|EFO:0001407|FMA:63934|SCTID:181455002|MA:0000386|MAT:0000279|Wikipedia:Placenta|MIAA:0000279|EMAPA:35689|CALOHA:TS-0799|OpenCyc:Mx4rvv4zZ5wpEbGdrcN5Y29ycA|BTO:0001078|NCIT:C13272	hp.json	eutherian placenta|allantoic placenta	http://purl.obolibrary.org/obo/UBERON_0001987		uberon_slim|organ_slim|pheno_slim|efo_slim
GO:0097152	biolink:BiologicalProcess	mesenchymal cell apoptotic process	Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.		hp.json	mesenchymal cell apoptosis	http://purl.obolibrary.org/obo/GO_0097152		
UBERON:0001986	biolink:AnatomicalEntity	endothelium	A layer of epithelium that lines the heart, blood vessels (endothelium, vascular), lymph vessels (endothelium, lymphatic), and the serous cavities of the body[MESH]. Simple squamous epithelium which lines blood and lymphatic vessels and the heart[FMA].	BTO:0000393|SCTID:27168002|MESH:D004727|GAID:520|UMLS:C0014257|EFO:0002548|galen:Endothelium|NCIT:C12481|CALOHA:TS-0278|FMA:63916	hp.json		http://purl.obolibrary.org/obo/UBERON_0001986		uberon_slim|efo_slim|human_reference_atlas
CHEBI:26347	biolink:ChemicalSubstance	prostanoid	The family of natural prostaglandins and prostaglandin-like compounds including prostacyclins and thromboxanes.		hp.json	prostanoids|prostanoid|prostanoids	http://purl.obolibrary.org/obo/CHEBI_26347		3_STAR
UBERON:0001988	biolink:AnatomicalEntity	feces	Portion of semisolid bodily waste discharged through the anus[MW,modified].	MIAA:0000053|CALOHA:TS-2345|Wikipedia:Feces|OpenCyc:Mx4rvVjJMZwpEbGdrcN5Y29ycA|FMA:64183|UMLS:C0015733|ENVO:00002003|NCIT:C13234|MA:0002509|GAID:1199|MAT:0000053|galen:Feces|MESH:D005243|BTO:0000440	hp.json	ordure|portion of feces|fecal matter|frass|portion of fecal matter|portion of excrement|spoor|guano|piece of shit|portion of dung|dung|cow dung|droppings|cow pat|piece of shit|stool|guano|spraint|excrement|frass|portion of guano|portionem cacas|portion of scat|scat|fecal material|portion of fecal material|portion of faeces|faeces|spraint|fewmet|cow dung|excreta|fewmet|cow pat	http://purl.obolibrary.org/obo/UBERON_0001988		uberon_slim|pheno_slim
CHEBI:26348	biolink:ChemicalSubstance	prosthetic group	A tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity.		hp.json	prosthetic group|prosthetic groups|groupe prosthetique	http://purl.obolibrary.org/obo/CHEBI_26348		3_STAR
GO:0014805	biolink:BiologicalProcess	smooth muscle adaptation	Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.		hp.json	smooth muscle plasticity	http://purl.obolibrary.org/obo/GO_0014805		
UBERON:0011313	biolink:AnatomicalEntity	posterior subdivision of masseter			hp.json	masseter, posterior	http://purl.obolibrary.org/obo/UBERON_0011313		
GO:0014807	biolink:BiologicalProcess	regulation of somitogenesis	Any process that modulates the frequency, rate or extent of somitogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_0014807		
UBERON:0011306	biolink:AnatomicalEntity	deep part of temporalis	The deep temporalis muscle is a separable part of the temporalis muscle that that attaches to the bony wall of the braincase and is deep to the superficial temporalis.	MFMO:0000086	hp.json	medial temporal|temporalis pars profunda|temporalis lamina profunda|temporalis pars posterior|temporal muscle posterior part|temporalis bbHauptmassebb|temporalis posterior head|posterior temporal	http://purl.obolibrary.org/obo/UBERON_0011306		
UBERON:0001994	biolink:AnatomicalEntity	hyaline cartilage tissue	Cartilage tissue primarily composed of type II collagen (thin fibrils) and a glassy appearance.	VSAO:0000094|UMLS:C0225362|EMAPA:35414|FMA:64783|MA:0000109|NCIT:C32746|XAO:0004029	hp.json	hyaline cartilage|chondroid cartilage	http://purl.obolibrary.org/obo/UBERON_0001994		pheno_slim|uberon_slim
UBERON:0001996	biolink:AnatomicalEntity	elastic cartilage tissue	Cartilage tissue that is flexible and contains abundant elastic fibers.	MA:0000485|VSAO:0000091|NCIT:C32494|XAO:0004197|FMA:64785|UMLS:C0682559|MA:0000107	hp.json	yellow elastic cartilage tissue|reticular cartilage|elastic cartilage tissue|yellow elastic cartilage|elastic cartilage|yellow cartilage	http://purl.obolibrary.org/obo/UBERON_0001996		pheno_slim|uberon_slim
UBERON:0001995	biolink:AnatomicalEntity	fibrocartilage	Cartilage tissue intermediate between hyaline cartilage and dense connective tissue; contains of abundant collagen fibers; chondrocytes often arranged in columns.	XAO:0004028|NCIT:C32599|VSAO:0000103|FMA:64784|MA:0000108|UMLS:C0684077|MESH:D051445|galen:Fibrocartilage	hp.json	fibrocartilage tissue|stratified cartilage tissue	http://purl.obolibrary.org/obo/UBERON_0001995		pheno_slim|uberon_slim
CHEBI:38323	biolink:ChemicalSubstance	cholinergic drug	Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons.		hp.json	cholinergic agent|cholinomimetic|cholinergic drugs	http://purl.obolibrary.org/obo/CHEBI_38323		3_STAR
GO:0002823	biolink:BiologicalProcess	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.		hp.json		http://purl.obolibrary.org/obo/GO_0002823		
GO:0002824	biolink:BiologicalProcess	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.		hp.json		http://purl.obolibrary.org/obo/GO_0002824		
GO:0097159	biolink:MolecularActivity	organic cyclic compound binding	Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.		hp.json		http://purl.obolibrary.org/obo/GO_0097159		
UBERON:0001979	biolink:AnatomicalEntity	venule	One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins.	MA:0000071|Wikipedia:Venule|FMA:63130|ZFA:0005315|EMAPA:35917|BTO:0002626|UMLS:C0042520|MESH:D014699|TAO:0005315|SCTID:341687009|VHOG:0001765|NCIT:C12818	hp.json	venula|venula	http://purl.obolibrary.org/obo/UBERON_0001979		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas
GO:0002831	biolink:BiologicalProcess	regulation of response to biotic stimulus	Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0002831		gocheck_do_not_manually_annotate
GO:0002832	biolink:BiologicalProcess	negative regulation of response to biotic stimulus	Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.		hp.json	down-regulation of response to biotic stimulus|down regulation of response to biotic stimulus|inhibition of response to biotic stimulus|downregulation of response to biotic stimulus	http://purl.obolibrary.org/obo/GO_0002832		gocheck_do_not_manually_annotate
GO:0002833	biolink:BiologicalProcess	positive regulation of response to biotic stimulus	Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.		hp.json	activation of response to biotic stimulus|stimulation of response to biotic stimulus|upregulation of response to biotic stimulus|up-regulation of response to biotic stimulus|up regulation of response to biotic stimulus	http://purl.obolibrary.org/obo/GO_0002833		gocheck_do_not_manually_annotate
UBERON:0001976	biolink:AnatomicalEntity	epithelium of esophagus	The epithelial layer that lines the luminal space of the esophagus.	FMA:63063|ZFA:0001499|EFO:0003041|MA:0001565|TAO:0001499|UMLS:C1179544|BTO:0001578|EHDAA2:0001287|EMAPA:16835|CALOHA:TS-0698|NCIT:C49221	hp.json	epithelial tissue of oesophagus|epithelial tissue of gullet|epithelium of oesophagus|epithelium of gullet|gullet epithelium|esophagus epithelium|epithelial tissue of esophagus|oesophagus epithelial tissue|esophagus epithelial tissue|gullet epithelial tissue|esophageal epithelium|oesophagus epithelium	http://purl.obolibrary.org/obo/UBERON_0001976		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0001975	biolink:AnatomicalEntity	serosa of esophagus	A serous membrane that is part of a esophagus [Automatically generated definition].	EMAPA:35322|MA:0001571|FMA:63057	hp.json	gullet serosa|esophagus serosa|serous membrane of esophagus|tunica serosa oesophageae|serous membrane of oesophagus|serous membrane of gullet|serosa of abdominal part of esophagus|oesophagus serosa|serous coat of oesophagus|oesophagus serous membrane|serosa of gullet|gullet serous membrane|serosa of oesophagus|esophagus serous membrane	http://purl.obolibrary.org/obo/UBERON_0001975		
UBERON:0001978	biolink:AnatomicalEntity	parenchyma of pancreas		MA:0000724|FMA:63120|VHOG:0001430|EMAPA:32925	hp.json	pancreas parenchyma|pancreatic parenchyma	http://purl.obolibrary.org/obo/UBERON_0001978		human_reference_atlas
GO:0061190	biolink:BiologicalProcess	regulation of sclerotome development	Any process that modulates the rate, frequency, or extent of the progression of the sclerotome over time, from its initial formation to the mature structure. The sclerotome is the portion of the somite that will give rise to a vertebra.		hp.json		http://purl.obolibrary.org/obo/GO_0061190		
UBERON:0001977	biolink:AnatomicalEntity	blood serum	The portion of blood plasma that excludes clotting factors.	MESH:D044967|EHDAA2:0004728|MA:0002502|FMA:63083|EMAPA:35770|UMLS:C0229671|NCIT:C13325|BTO:0001239|CALOHA:TS-0923|BTO:0000133	hp.json	serum	http://purl.obolibrary.org/obo/UBERON_0001977		uberon_slim|pheno_slim
GO:0097164	biolink:BiologicalProcess	ammonium ion metabolic process	The chemical reactions and pathways involving the ammonium ion.		hp.json	ammonium ion metabolism|ammonium metabolic process	http://purl.obolibrary.org/obo/GO_0097164		
GO:0061193	biolink:BiologicalProcess	taste bud development	The progression of the taste bud over time, from its formation to the mature state. The taste bud is a specialized area of the tongue that contains taste receptors.		hp.json		http://purl.obolibrary.org/obo/GO_0061193		
GO:0061194	biolink:BiologicalProcess	taste bud morphogenesis	The process in which the anatomical structures of the taste bud are generated and organized. The taste bud is a specialized area of the tongue that contains taste receptors.		hp.json		http://purl.obolibrary.org/obo/GO_0061194		
GO:0061195	biolink:BiologicalProcess	taste bud formation	The developmental process pertaining to the initial formation of the taste bud from unspecified parts. The taste bud is a specialized area of the tongue that contains taste receptors.		hp.json		http://purl.obolibrary.org/obo/GO_0061195		
GO:0014819	biolink:BiologicalProcess	regulation of skeletal muscle contraction	Any process that modulates the frequency, rate or extent of skeletal muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_0014819		
UBERON:0011300	biolink:AnatomicalEntity	gray matter of telencephalon	A portion of gray matter that is part of a telencephalon.	FMA:83911|BIRNLEX:1067	hp.json	predominantly gray regional part of telencephalon	http://purl.obolibrary.org/obo/UBERON_0011300		
CHEBI:38337	biolink:ChemicalSubstance	pyrimidone	A pyrimidine carrying one or more oxo substituents.		hp.json	pyrimidones	http://purl.obolibrary.org/obo/CHEBI_38337		3_STAR
GO:0014812	biolink:BiologicalProcess	muscle cell migration	The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0014812		
UBERON:0001982	biolink:AnatomicalEntity	capillary	Any of the smallest blood vessels connecting arterioles with venules.	EMAPA:35198|Wikipedia:Capillary|OpenCyc:Mx4rvWEU-5wpEbGdrcN5Y29ycA|NCIT:C12685|MA:0000065|EV:0100035|UMLS:C0935624|AAO:0010252|NLXANAT:090902|ZFA:0005250|MESH:D002196|EFO:0001906|BTO:0002045|CALOHA:TS-2006|XAO:0000116|TAO:0005250|FMA:63194|VHOG:0001253	hp.json	blood capillary|capillary vessel	http://purl.obolibrary.org/obo/UBERON_0001982		vertebrate_core|pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0001985	biolink:AnatomicalEntity	corneal endothelium	A monolayer of specialized, flattened, mitochondria-rich cells that lines the posterior surface of the cornea and faces the anterior chamber of the eye[WP].	MESH:D004728|ZFA:0001687|GAID:891|CALOHA:TS-0172|EMAPA:35935|MA:0001242|Wikipedia:Corneal_endothelium|SCTID:368827009|FMA:63882|TAO:0002186|UMLS:C0014259|NCIT:C12707	hp.json	epithelium posterius corneae|endothelium of cornea|cornea endothelium|epithelium posterius corneae	http://purl.obolibrary.org/obo/UBERON_0001985		vertebrate_core|pheno_slim|human_reference_atlas|uberon_slim
UBERON:0001981	biolink:AnatomicalEntity	blood vessel	A vessel through which blood circulates in the body.	Wikipedia:Blood_vessel|NCIT:C12679|VHOG:0001250|ZFA:0005314|FMA:50722|XAO:0001011|TAO:0002137|SCTID:361097006|AEO:0000207|AAO:0011004|EMAPA:32743|MESH:D001808|CALOHA:TS-0080|EHDAA:240|BTO:0001102|OpenCyc:Mx4rvVjxlpwpEbGdrcN5Y29ycA|MA:0000060|NLXANAT:090901|MAT:0000393|EHDAA2:0003252|EFO:0000817|EMAPA:35993|UMLS:C0005847|FMA:63183|GAID:169	hp.json	vascular tree organ region|vas sanguineum|vas sanguineum|region of vascular tree organ|vascular element	http://purl.obolibrary.org/obo/UBERON_0001981		vertebrate_core|pheno_slim|efo_slim|uberon_slim
UBERON:0001980	biolink:AnatomicalEntity	arteriole	The smallest division of the artery located between the muscular arteries and the capillaries[GO].	FMA:63182|Wikipedia:Arteriole|TAO:0002138|BTO:0001997|ZFA:0005255|MA:0000063|NCIT:C12672|AAO:0010253|UMLS:C0003847|SCTID:337724002|VHOG:0001763|EMAPA:35146|MESH:D001160	hp.json	arteriola|arteriola	http://purl.obolibrary.org/obo/UBERON_0001980		vertebrate_core|pheno_slim|uberon_slim
UBERON:0001969	biolink:AnatomicalEntity	blood plasma	The liquid component of blood, in which erythrocytes are suspended.	MAT:0000052|BTO:0000131|EFO:0001905|MIAA:0000052|MA:0002501|EMAPA:35690|Wikipedia:Blood_plasma|NCIT:C13356|UMLS:C0032105|OpenCyc:Mx4rEg4ZYrIbEduAAAAOpmP6tw|GAID:1178|CALOHA:TS-0800|FMA:62970|MESH:D010949	hp.json	portion of plasma|plasma|blood plasm|portion of blood plasma	http://purl.obolibrary.org/obo/UBERON_0001969		efo_slim|uberon_slim|pheno_slim
UBERON:8410081	biolink:AnatomicalEntity	blood microvessel	Any of the smallest blood vessels where blood circulates within organ tissues. Microvessels include terminal arterioles, metarterioles, capillaries, and venules (but exclude lymphatic capillaries). Arterioles carry oxygenated blood to the capillaries, and blood flows out of the capillaries through venules into veins.		hp.json	microvasculature|microvessel	http://purl.obolibrary.org/obo/UBERON_8410081		
UBERON:0001968	biolink:AnatomicalEntity	semen	Organism substance that is composed of sperm cells suspended in seminal fluid.	OpenCyc:Mx4rvgC-zpwpEbGdrcN5Y29ycA|BTO:0001230|NCIT:C13713|UMLS:C2756969|FMA:62966|CALOHA:TS-0917|MA:0002522|GAID:1169|UMLS:C1518159|MESH:D012661|NCIT:C13277|EMAPA:31488	hp.json	ejaculate|sperm	http://purl.obolibrary.org/obo/UBERON_0001968		uberon_slim|pheno_slim
UBERON:8410080	biolink:AnatomicalEntity	red bone marrow of sternum	Red bone marrow located in the sternum.		hp.json	sternum red bone marrow	http://purl.obolibrary.org/obo/UBERON_8410080		
CHEBI:38304	biolink:ChemicalSubstance	diazolidine			hp.json	diazolidines	http://purl.obolibrary.org/obo/CHEBI_38304		3_STAR
UBERON:0001972	biolink:AnatomicalEntity	submucosa of esophagus	A submucosa that is part of a esophagus [Automatically generated definition].	FMA:62997|BTO:0002109|SCTID:362128009|EMAPA:35325|MA:0002724	hp.json	submucosa of esophagus|oesophagus submucosa|gullet submucosa|esophagus submucosa|tela submucosa oesophageae|tela submucosa of esophagus|tela submucosa esophagi|submucosa of oesophagus|submucosa of gullet|tela submucosa (oesophagus)|esophageal submucosa|tela submucosa oesophagi|submucous layer of esophagus	http://purl.obolibrary.org/obo/UBERON_0001972		
UBERON:0001971	biolink:AnatomicalEntity	gastric juice	.	GAID:1160|Wikipedia:Gastric_juice|UMLS:C0017133|galen:GastricJuice|BTO:0000501|NCIT:C32661|FMA:62972|MA:0002519|MESH:D005750	hp.json	stomach secretion|succus gastricus	http://purl.obolibrary.org/obo/UBERON_0001971		pheno_slim|uberon_slim
UBERON:8410079	biolink:AnatomicalEntity	red bone marrow of iliac crest	Red bone marrow located in an iliac crest.		hp.json	iliac crest red bone marrow	http://purl.obolibrary.org/obo/UBERON_8410079		
UBERON:0001974	biolink:AnatomicalEntity	lamina propria of esophagus	A lamina propria that is part of a esophagus [Automatically generated definition].	MA:0001568|FMA:63050|NCIT:C49223|EMAPA:26987|UMLS:C1707949	hp.json	lamina propria of oesophagus|esophageal lamina propria|esophagus lamina propria mucosae|gullet lamina propria mucosae|lamina propria of gullet|oesophagus lamina propria mucosae|lamina propria mucosa of oesophagus|gullet lamina propria|lamina propria mucosa of gullet|esophagus lamina propria|lamina propria mucosa of esophagus|oesophagus lamina propria|oesophagus lamina propria mucosa|lamina propria mucosae of oesophagus|lamina propria mucosae of esophagus|lamina propria mucosae of gullet|esophagus lamina propria mucosa|gullet lamina propria mucosa	http://purl.obolibrary.org/obo/UBERON_0001974		
UBERON:0001970	biolink:AnatomicalEntity	bile	Vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium.	NCIT:C13192|galen:Bile|MA:0002513|MESH:D001646|ENVO:02000023|CALOHA:TS-1172|GAID:1157|FMA:62971|BTO:0000121|UMLS:C0005388|ZFA:0005857	hp.json	fel|gall	http://purl.obolibrary.org/obo/UBERON_0001970		pheno_slim|uberon_slim
UBERON:0001958	biolink:AnatomicalEntity	terminal bronchiole epithelium	An epithelium that lines a terminal bronchiole.	FMA:62794|UMLS:C1179400|NCIT:C33755|MA:0001774|EMAPA:36283	hp.json	epithelium of bronchiolus terminalis|epithelial tissue of terminal bronchiole|bronchiolus terminalis epithelium|terminal bronchiole epithelium|epithelium of terminal bronchiole|terminal bronchiole epithelial tissue|bronchiolus terminalis epithelial tissue|epithelial tissue of bronchiolus terminalis	http://purl.obolibrary.org/obo/UBERON_0001958		
CHEBI:26338	biolink:ChemicalSubstance	prostaglandins E			hp.json	PGE	http://purl.obolibrary.org/obo/CHEBI_26338		3_STAR
UBERON:0001957	biolink:AnatomicalEntity	submucosa of bronchus	A submucosa that is part of a bronchus [Automatically generated definition].	MA:0001837|UMLS:C0225601|EMAPA:37449|BTO:0002108|FMA:62653|NCIT:C49214	hp.json	bronchi submucosa|bronchial trunk submucosa|bronchus submucosa|bronchial submucosa|tela submucosa bronchi|submucous layer of bronchi|submucosa of bronchi|submucosa of bronchial trunk	http://purl.obolibrary.org/obo/UBERON_0001957		
UBERON:0001959	biolink:AnatomicalEntity	white pulp of spleen	The parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies.	UMLS:C0229686|FMA:62805|EMAPA:35809|CALOHA:TS-1264|MA:0000762|NCIT:C12993	hp.json	pulpa alba|noduli lymphoidei splenici|spleen white pulp|white pulp|splenic white pulp	http://purl.obolibrary.org/obo/UBERON_0001959		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0001954	biolink:AnatomicalEntity	Ammon's horn	A part of the brain consisting of a three layered cortex located in the forebrain bordering the medial surface of the lateral ventricle. The term hippocampus is often used synonymously with hippocampal formation which consists of the hippocampus proper or Cornu Ammonis, the dentate gyrus and the subiculum.	MA:0000191|BAMS:CA|EMAPA:32772|MBA:375|FMA:62493|GAID:623|VHOG:0001177|EV:0100180|BM:Tel-CAM|PBA:128012244|DMBA:16124|BTO:0003705|CALOHA:TS-0460|OpenCyc:Mx4rv3piFJwpEbGdrcN5Y29ycA|UMLS:C0019564|EMAPA:32845|UMLS:C0019564|NCIT:C12444|MAT:0000114|MESH:D006624|DHBA:10296|BIRNLEX:721|NCIT:C32374|MIAA:0000114|EFO:0000530|EHDAA2:0004443	hp.json	hippocampus|hippocampus major|cornu ammonis|hippocampus proprius|Ammons horn|Ammon horn fields|ammon gyrus|hippocampus proper|ammon horn|Ammon's horn	http://purl.obolibrary.org/obo/UBERON_0001954		efo_slim|uberon_slim|pheno_slim
UBERON:0001956	biolink:AnatomicalEntity	cartilage of bronchus	The hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles[MP].	MA:0001835|FMA:62649|NCIT:C49209|UMLS:C0225604|EMAPA:35192	hp.json	bronchial cartilage ring|bronchi cartilage|cartilagines bronchiales|cartilage of bronchi|bronchial trunk cartilage|cartilage of bronchial trunk|bronchus cartilage|bronchial cartilage	http://purl.obolibrary.org/obo/UBERON_0001956		pheno_slim
UBERON:8410077	biolink:AnatomicalEntity	airway submucosal gland	A submucosal gland found in a respiratory tract.	EFO:0010666	hp.json	respiratory tract submucosal gland|submucosal gland of respiratory tract	http://purl.obolibrary.org/obo/UBERON_8410077		
CHEBI:26333	biolink:ChemicalSubstance	prostaglandin	Naturally occurring compounds derived from the parent C20 acid, prostanoic acid.	LIPID_MAPS_class:LMFA0301|CAS:11000-26-3	hp.json	prostaglandins|prostaglandins|prostaglandin	http://purl.obolibrary.org/obo/CHEBI_26333		3_STAR
CHEBI:38316	biolink:ChemicalSubstance	pyrimidinecarboxylate anion			hp.json	pyrimidinecarboxylate anions	http://purl.obolibrary.org/obo/CHEBI_38316		3_STAR
CHEBI:38313	biolink:ChemicalSubstance	diazines	Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure).		hp.json		http://purl.obolibrary.org/obo/CHEBI_38313		3_STAR
UBERON:0001961	biolink:AnatomicalEntity	mucosa-associated lymphoid tissue	Diffuse system of small concentrations of lymphoid tissue found in various sites of the body such as the gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin[WP]. Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes[GO].	NCIT:C12910|UMLS:C0599921|MA:0000140|FMA:62819	hp.json	mucosa-associated lymphoid tissue|epithelio-lymphoid tissue|MALT|mucosa associated lymphatic tissue|mucosal-associated lymphoid tissue|mucosa associated lymphoid tissue|mucosal-associated lymphatic tissue	http://purl.obolibrary.org/obo/UBERON_0001961		uberon_slim|pheno_slim|human_reference_atlas
UBERON:0001960	biolink:AnatomicalEntity	periarterial lymphatic sheath	The area of the spleen in which T cells surround the central arteriole.	MA:0000765|FMA:62810|EMAPA:37750	hp.json	periarterial lymphoid sheath|T cell domain of the splenic white pulp|PALS|spleen periarteriolar lymphatic sheath|periarteriolar sheath|splenic periarteriolar lymphoid sheath	http://purl.obolibrary.org/obo/UBERON_0001960		pheno_slim|human_reference_atlas
UBERON:8410068	biolink:AnatomicalEntity	capillary of small intestine	A capillary that is part of a small intestine.		hp.json	small intestine capillary|blood vessel capillary of small intestine	http://purl.obolibrary.org/obo/UBERON_8410068		location_grouping
UBERON:0001963	biolink:AnatomicalEntity	bronchial-associated lymphoid tissue	A diffuse collection of lymphpoid cells that participate in airway immune responses.	UMLS:C1179418|MA:0000135|FMA:62821|NCIT:C32234	hp.json	BALT|bronchus associated lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0001963		pheno_slim|human_reference_atlas
UBERON:0001962	biolink:AnatomicalEntity	gut-associated lymphoid tissue	Mucosa-associated lymphoid tissue in digestive tract. includes Peyer's patches, appendix, and solitary lymph nodules[GO].	NCIT:C12936|MA:0000136|UMLS:C0596638|FMA:62820	hp.json	gut associated lymphoid tissue|GALT	http://purl.obolibrary.org/obo/UBERON_0001962		uberon_slim|pheno_slim|human_reference_atlas
GO:0002819	biolink:BiologicalProcess	regulation of adaptive immune response	Any process that modulates the frequency, rate, or extent of an adaptive immune response.		hp.json		http://purl.obolibrary.org/obo/GO_0002819		
GO:1903509	biolink:BiologicalProcess	liposaccharide metabolic process	The chemical reactions and pathways involving liposaccharide.		hp.json	liposaccharide metabolism	http://purl.obolibrary.org/obo/GO_1903509		
CL:0011027	biolink:Cell	skeletal muscle fibroblast	Any fibroblast that is part of skeletal muscle tissue.		hp.json	skeleton muscle fibroblast	http://purl.obolibrary.org/obo/CL_0011027		
CL:0011026	biolink:Cell	progenitor cell	A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.		hp.json		http://purl.obolibrary.org/obo/CL_0011026		
CL:0011025	biolink:Cell	exhausted T cell			hp.json	Tex cell|An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential.	http://purl.obolibrary.org/obo/CL_0011025		
CL:0011022	biolink:Cell	fibroblast of skin of back	A fibroblast that is part of skin of back.		hp.json		http://purl.obolibrary.org/obo/CL_0011022		
CHEBI:63299	biolink:ChemicalSubstance	carbohydrate derivative	Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds.		hp.json	derivatised carbohydrate|derivatized carbohydrates|derivatized carbohydrate|carbohydrate derivatives|derivatised carbohydrates	http://purl.obolibrary.org/obo/CHEBI_63299		3_STAR
GO:0048103	biolink:BiologicalProcess	somatic stem cell division	The self-renewing division of a somatic stem cell, a stem cell that can give rise to cell types of the body other than those of the germ-line.		hp.json	somatic stem cell renewal	http://purl.obolibrary.org/obo/GO_0048103		
CL:0011021	biolink:Cell	fibroblast of upper back skin	A fibroblast that is part of upper back skin.		hp.json		http://purl.obolibrary.org/obo/CL_0011021		
CL:0011012	biolink:Cell	neural crest cell	A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.		hp.json		http://purl.obolibrary.org/obo/CL_0011012		
GO:1903510	biolink:BiologicalProcess	mucopolysaccharide metabolic process	The chemical reactions and pathways involving mucopolysaccharide.		hp.json	mucopolysaccharide metabolism	http://purl.obolibrary.org/obo/GO_1903510		
CL:0011019	biolink:Cell	mesothelial cell of epicardium	A mesothelial cell that is part of the epicardium.		hp.json		http://purl.obolibrary.org/obo/CL_0011019		
CL:0011005	biolink:Cell	GABAergic interneuron	An interneuron that uses GABA as a vesicular neurotransmitter.  These interneurons are inhibitory		hp.json	GABAergic inhibitory interneuron	http://purl.obolibrary.org/obo/CL_0011005		
GO:1903524	biolink:BiologicalProcess	positive regulation of blood circulation	Any process that activates or increases the frequency, rate or extent of blood circulation.		hp.json	upregulation of hemolymph circulation|up-regulation of blood circulation|activation of hemolymph circulation|up regulation of blood circulation|activation of blood circulation|up-regulation of hemolymph circulation|up regulation of hemolymph circulation|upregulation of blood circulation|positive regulation of hemolymph circulation	http://purl.obolibrary.org/obo/GO_1903524		
GO:1903523	biolink:BiologicalProcess	negative regulation of blood circulation	Any process that stops, prevents or reduces the frequency, rate or extent of blood circulation.		hp.json	down-regulation of hemolymph circulation|negative regulation of hemolymph circulation|inhibition of blood circulation|downregulation of blood circulation|down regulation of hemolymph circulation|downregulation of hemolymph circulation|down-regulation of blood circulation|inhibition of hemolymph circulation|down regulation of blood circulation	http://purl.obolibrary.org/obo/GO_1903523		
CL:0011001	biolink:Cell	spinal cord motor neuron	A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.		hp.json		http://purl.obolibrary.org/obo/CL_0011001		
GO:1903522	biolink:BiologicalProcess	regulation of blood circulation	Any process that modulates the frequency, rate or extent of blood circulation.		hp.json	regulation of hemolymph circulation	http://purl.obolibrary.org/obo/GO_1903522		
GO:0061100	biolink:BiologicalProcess	lung neuroendocrine cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the lung epithelium.		hp.json		http://purl.obolibrary.org/obo/GO_0061100		
PR:000001483	biolink:Protein	low affinity immunoglobulin gamma Fc region receptor III	An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr3 gene or a 1:1 ortholog thereof.		hp.json	CD16|FcRIII|IgG Fc receptor III|Fc-gamma RIII|Fcgr3	http://purl.obolibrary.org/obo/PR_000001483		
GO:0061101	biolink:BiologicalProcess	neuroendocrine cell differentiation	The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a neuroendocrine cell. A neuroendocrine cell is a cell that receives input form a neuron which controls the secretion of an endocrine substance.		hp.json		http://purl.obolibrary.org/obo/GO_0061101		
GO:0061102	biolink:BiologicalProcess	stomach neuroendocrine cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuroendocrine cell of the stomach epithelium.		hp.json	gastric neuroendocrine cell differentiation	http://purl.obolibrary.org/obo/GO_0061102		
GO:0061105	biolink:BiologicalProcess	regulation of stomach neuroendocrine cell differentiation	Any process that modulates the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.		hp.json		http://purl.obolibrary.org/obo/GO_0061105		
GO:0061106	biolink:BiologicalProcess	negative regulation of stomach neuroendocrine cell differentiation	Any process that decreases the rate, frequency or extent of the differentiation of a neuroendocrine cell in the stomach.		hp.json		http://purl.obolibrary.org/obo/GO_0061106		
CL:0011007	biolink:Cell	paraxial cell	A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites.		hp.json	paraxial mesoderm cell|presomitic mesoderm cell|somitic mesoderm cell	http://purl.obolibrary.org/obo/CL_0011007		
GO:0051784	biolink:BiologicalProcess	negative regulation of nuclear division	Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.		hp.json	inhibition of nuclear division|down-regulation of nuclear division|downregulation of nuclear division|down regulation of nuclear division	http://purl.obolibrary.org/obo/GO_0051784		
GO:0048132	biolink:BiologicalProcess	female germ-line stem cell asymmetric division	The self-renewing division of a germline stem cell in the female gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the female gametes.		hp.json	female germ-line stem cell renewal	http://purl.obolibrary.org/obo/GO_0048132		
GO:0051785	biolink:BiologicalProcess	positive regulation of nuclear division	Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.		hp.json	upregulation of nuclear division|stimulation of nuclear division|up regulation of nuclear division|up-regulation of nuclear division|activation of nuclear division	http://purl.obolibrary.org/obo/GO_0051785		
GO:1903538	biolink:BiologicalProcess	regulation of meiotic cell cycle process involved in oocyte maturation	Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.		hp.json	regulation of meiosis involved in oocyte maturation	http://purl.obolibrary.org/obo/GO_1903538		
GO:1903537	biolink:BiologicalProcess	meiotic cell cycle process involved in oocyte maturation	Any meiotic cell cycle process that is involved in oocyte maturation.		hp.json	meiosis involved in oocyte maturation	http://purl.obolibrary.org/obo/GO_1903537		
GO:1903532	biolink:BiologicalProcess	positive regulation of secretion by cell	Any process that activates or increases the frequency, rate or extent of secretion by cell.		hp.json	positive regulation of cellular secretion|up regulation of secretion by cell|up regulation of cellular secretion|activation of secretion by cell|up-regulation of cellular secretion|activation of cellular secretion|upregulation of secretion by cell|upregulation of cellular secretion|up-regulation of secretion by cell	http://purl.obolibrary.org/obo/GO_1903532		
GO:1903531	biolink:BiologicalProcess	negative regulation of secretion by cell	Any process that stops, prevents or reduces the frequency, rate or extent of secretion by cell.		hp.json	downregulation of cellular secretion|down-regulation of secretion by cell|down regulation of cellular secretion|down regulation of secretion by cell|inhibition of cellular secretion|down-regulation of cellular secretion|negative regulation of cellular secretion|inhibition of secretion by cell|downregulation of secretion by cell	http://purl.obolibrary.org/obo/GO_1903531		
GO:1903530	biolink:BiologicalProcess	regulation of secretion by cell	Any process that modulates the frequency, rate or extent of secretion by cell.		hp.json	regulation of cellular secretion	http://purl.obolibrary.org/obo/GO_1903530		
GO:0051782	biolink:BiologicalProcess	negative regulation of cell division	Any process that stops, prevents, or reduces the frequency, rate or extent of cell division.		hp.json	down-regulation of cell division|down regulation of cell division|inhibition of cell division|downregulation of cell division	http://purl.obolibrary.org/obo/GO_0051782		
UBERON:4300226	biolink:AnatomicalEntity	forelimb bud mesenchyme	Mesenchyme that is part of a forelimb bud.		hp.json		http://purl.obolibrary.org/obo/UBERON_4300226		
GO:0051783	biolink:BiologicalProcess	regulation of nuclear division	Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information.		hp.json		http://purl.obolibrary.org/obo/GO_0051783		
UBERON:4300227	biolink:AnatomicalEntity	hindlimb bud mesenchyme	Mesenchyme that is part of a hindlimb bud.		hp.json		http://purl.obolibrary.org/obo/UBERON_4300227		
GO:0051781	biolink:BiologicalProcess	positive regulation of cell division	Any process that activates or increases the frequency, rate or extent of cell division.		hp.json	up regulation of cell division|activation of cell division|stimulation of cell division|upregulation of cell division|up-regulation of cell division	http://purl.obolibrary.org/obo/GO_0051781		
GO:0048145	biolink:BiologicalProcess	regulation of fibroblast proliferation	Any process that modulates the frequency, rate or extent of multiplication or reproduction of fibroblast cells.		hp.json		http://purl.obolibrary.org/obo/GO_0048145		
GO:0048144	biolink:BiologicalProcess	fibroblast proliferation	The multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population.		hp.json		http://purl.obolibrary.org/obo/GO_0048144		
GO:0002784	biolink:BiologicalProcess	regulation of antimicrobial peptide production	Any process that modulates the frequency, rate, or extent of antimicrobial peptide production.		hp.json		http://purl.obolibrary.org/obo/GO_0002784		
GO:0002785	biolink:BiologicalProcess	negative regulation of antimicrobial peptide production	Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.		hp.json	down regulation of antimicrobial peptide production|inhibition of antimicrobial peptide production|down-regulation of antimicrobial peptide production|downregulation of antimicrobial peptide production	http://purl.obolibrary.org/obo/GO_0002785		
GO:1903543	biolink:BiologicalProcess	positive regulation of exosomal secretion	Any process that activates or increases the frequency, rate or extent of exosomal secretion.		hp.json	positive regulation of exosomal protein secretion|upregulation of extracellular vesicular exosome secretion|positive regulation of exosomal secretory pathway|positive regulation of secretion of exosome|up regulation of exosomal protein secretion|up regulation of exosomal secretory pathway|up regulation of secretion of exosome|up-regulation of exosomal protein secretion|upregulation of exosomal secretion|activation of exosomal secretory pathway|up-regulation of exosomal secretory pathway|up-regulation of secretion of exosome|activation of secretion of exosome|up-regulation of extracellular vesicular exosome secretion|up regulation of extracellular vesicular exosome secretion|up regulation of exosomal secretion|activation of exosomal protein secretion|upregulation of exosomal protein secretion|activation of extracellular vesicular exosome secretion|upregulation of exosomal secretory pathway|positive regulation of extracellular vesicular exosome secretion|upregulation of secretion of exosome|up-regulation of exosomal secretion|activation of exosomal secretion	http://purl.obolibrary.org/obo/GO_1903543		
GO:1903542	biolink:BiologicalProcess	negative regulation of exosomal secretion	Any process that stops, prevents or reduces the frequency, rate or extent of exosomal secretion.		hp.json	negative regulation of extracellular vesicular exosome secretion|inhibition of exosomal protein secretion|down-regulation of extracellular vesicular exosome secretion|down regulation of exosomal secretion|inhibition of exosomal secretion|down regulation of extracellular vesicular exosome secretion|down-regulation of exosomal secretion|downregulation of exosomal protein secretion|downregulation of exosomal secretory pathway|downregulation of secretion of exosome|inhibition of extracellular vesicular exosome secretion|downregulation of extracellular vesicular exosome secretion|down regulation of exosomal secretory pathway|down regulation of exosomal protein secretion|down regulation of secretion of exosome|inhibition of exosomal secretory pathway|inhibition of secretion of exosome|negative regulation of exosomal protein secretion|down-regulation of exosomal secretory pathway|negative regulation of exosomal secretory pathway|down-regulation of exosomal protein secretion|negative regulation of secretion of exosome|downregulation of exosomal secretion|down-regulation of secretion of exosome	http://purl.obolibrary.org/obo/GO_1903542		
GO:0048147	biolink:BiologicalProcess	negative regulation of fibroblast proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.		hp.json	downregulation of fibroblast proliferation|down regulation of fibroblast proliferation|inhibition of fibroblast proliferation|down-regulation of fibroblast proliferation	http://purl.obolibrary.org/obo/GO_0048147		
GO:0048146	biolink:BiologicalProcess	positive regulation of fibroblast proliferation	Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.		hp.json	activation of fibroblast proliferation|upregulation of fibroblast proliferation|up regulation of fibroblast proliferation|stimulation of fibroblast proliferation|up-regulation of fibroblast proliferation	http://purl.obolibrary.org/obo/GO_0048146		
GO:1903541	biolink:BiologicalProcess	regulation of exosomal secretion	Any process that modulates the frequency, rate or extent of exosomal secretion.		hp.json	regulation of extracellular vesicular exosome secretion|regulation of exosomal secretory pathway|regulation of exosomal protein secretion|regulation of secretion of exosome	http://purl.obolibrary.org/obo/GO_1903541		
GO:1903551	biolink:BiologicalProcess	regulation of extracellular exosome assembly	Any process that modulates the frequency, rate or extent of extracellular vesicular exosome assembly.		hp.json	regulation of extracellular vesicular exosome assembly	http://purl.obolibrary.org/obo/GO_1903551		
OBO:MAXO_0010220	biolink:NamedThing	prostate ultrasonography	The use of ultrasound to produce images of structures in the prostate gland.		hp.json	prostate gland ultrasound examination|prostate gland medical ultrasound|prostate gland ultrasound imaging procedure|prostate gland diagnostic sonography|sonography of prostate gland|ultrasonography of prostate gland|prostate gland sonography|prostate gland ultrasound procedure	http://purl.obolibrary.org/obo/MAXO_0010220		
OBO:MAXO_0010222	biolink:NamedThing	neurosonology	The use of ultrasound to produce images of structures in the brain.		hp.json	brain ultrasound procedure|brain ultrasound examination|brain medical ultrasound|ultrasonography of brain|brain ultrasound imaging procedure|brain diagnostic sonography|sonography of brain|brain sonography	http://purl.obolibrary.org/obo/MAXO_0010222		
UBERON:8410015	biolink:AnatomicalEntity	arteriole of colon	An arteriole located in the colon.		hp.json		http://purl.obolibrary.org/obo/UBERON_8410015		
GO:0099738	biolink:CellularComponent	cell cortex region	The complete extent of cell cortex that underlies some some region of the plasma membrane.		hp.json	perimembrane region	http://purl.obolibrary.org/obo/GO_0099738		gocheck_do_not_annotate
UBERON:8410016	biolink:AnatomicalEntity	descending sigmoid junction	The anatomical junction between the descending colon and the sigmoid colon.		hp.json	descending-sigmoid colon junction|descending-sigmoid junction|sigmoid junction	http://purl.obolibrary.org/obo/UBERON_8410016		
UBERON:8410017	biolink:AnatomicalEntity	left colic vein	A portal vein that drains the descending colon. It is a tributary of the inferior mesenteric vein, and follows the path of its corresponding artery, the left colic artery.	FMA:15394	hp.json		http://purl.obolibrary.org/obo/UBERON_8410017		
UBERON:8410019	biolink:AnatomicalEntity	jejuno-ileal junction	The area where the jejunum ends and the ileum part of the intestine begins. Although there is no clear distinct section, the ileum is narrower and has smaller villi than the jejunum.		hp.json	jejunoileal junction	http://purl.obolibrary.org/obo/UBERON_8410019		
GO:0002793	biolink:BiologicalProcess	positive regulation of peptide secretion	Any process that activates or increases the frequency, rate, or extent of peptide secretion.		hp.json	up-regulation of peptide secretion|up regulation of peptide secretion|activation of peptide secretion|stimulation of peptide secretion|upregulation of peptide secretion	http://purl.obolibrary.org/obo/GO_0002793		
GO:0002794	biolink:BiologicalProcess	regulation of antimicrobial peptide secretion	Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion.		hp.json		http://purl.obolibrary.org/obo/GO_0002794		
GO:0002795	biolink:BiologicalProcess	negative regulation of antimicrobial peptide secretion	Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion.		hp.json	down-regulation of antimicrobial peptide secretion|down regulation of antimicrobial peptide secretion|downregulation of antimicrobial peptide secretion|inhibition of antimicrobial peptide secretion	http://purl.obolibrary.org/obo/GO_0002795		
GO:0002796	biolink:BiologicalProcess	positive regulation of antimicrobial peptide secretion	Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion.		hp.json	up regulation of antimicrobial peptide secretion|activation of antimicrobial peptide secretion|stimulation of antimicrobial peptide secretion|upregulation of antimicrobial peptide secretion|up-regulation of antimicrobial peptide secretion	http://purl.obolibrary.org/obo/GO_0002796		
OBO:MAXO_0010212	biolink:NamedThing	spleen ultrasonography	The use of ultrasound to produce images of structures in the spleen.		hp.json	spleen diagnostic sonography|sonography of spleen|spleen ultrasound imaging procedure|ultrasonography of spleen|spleen sonography|spleen ultrasound procedure|spleen ultrasound examination|spleen medical ultrasound	http://purl.obolibrary.org/obo/MAXO_0010212		
OBO:MAXO_0010213	biolink:NamedThing	stomach ultrasonography	The use of ultrasound to produce images of structures in the stomach.		hp.json	stomach sonography|stomach ultrasound procedure|stomach ultrasound examination|stomach medical ultrasound|ultrasonography of stomach|stomach diagnostic sonography|stomach ultrasound imaging procedure|sonography of stomach	http://purl.obolibrary.org/obo/MAXO_0010213		
GO:0002790	biolink:BiologicalProcess	peptide secretion	The controlled release of a peptide from a cell or a tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0002790		
GO:0002791	biolink:BiologicalProcess	regulation of peptide secretion	Any process that modulates the frequency, rate, or extent of peptide secretion.		hp.json		http://purl.obolibrary.org/obo/GO_0002791		
OBO:MAXO_0010214	biolink:NamedThing	thyroid ultrasonography	The use of ultrasound to produce images of structures in the thyroid gland.		hp.json	thyroid gland medical ultrasound|ultrasonography of thyroid gland|thyroid gland diagnostic sonography|thyroid gland ultrasound imaging procedure|sonography of thyroid gland|thyroid gland sonography|thyroid gland ultrasound procedure|thyroid gland ultrasound examination	http://purl.obolibrary.org/obo/MAXO_0010214		
OBO:MAXO_0010215	biolink:NamedThing	bladder ultrasonography	The use of ultrasound to produce images of structures in the urinary bladder.		hp.json	urinary bladder ultrasound imaging procedure|urinary bladder sonography|ultrasonography of urinary bladder|urinary bladder ultrasound procedure|urinary bladder diagnostic sonography|urinary bladder ultrasound examination|sonography of urinary bladder|urinary bladder medical ultrasound	http://purl.obolibrary.org/obo/MAXO_0010215		
GO:0002792	biolink:BiologicalProcess	negative regulation of peptide secretion	Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.		hp.json	downregulation of peptide secretion|down-regulation of peptide secretion|down regulation of peptide secretion|inhibition of peptide secretion	http://purl.obolibrary.org/obo/GO_0002792		
OBO:MAXO_0010216	biolink:NamedThing	vaginal ultrasonography	The use of ultrasound to produce images of structures in the vagina.		hp.json	vagina ultrasound examination|vagina medical ultrasound|vagina diagnostic sonography|sonography of vagina|vagina ultrasound imaging procedure|ultrasonography of vagina|vagina sonography|vagina ultrasound procedure	http://purl.obolibrary.org/obo/MAXO_0010216		
OBO:MAXO_0010217	biolink:NamedThing	renal ultrasonography	The use of ultrasound to produce images of structures in the kidney.		hp.json	kidney ultrasound imaging procedure|kidney diagnostic sonography|sonography of kidney|kidney sonography|kidney ultrasound procedure|ultrasonography of kidney|kidney ultrasound examination|kidney medical ultrasound	http://purl.obolibrary.org/obo/MAXO_0010217		
OBO:MAXO_0010218	biolink:NamedThing	carotid ultrasonography	The use of ultrasound to produce images of structures in the carotid artery segment.		hp.json	ultrasonography of carotid artery segment|carotid artery segment sonography|carotid artery segment ultrasound procedure|carotid artery segment ultrasound examination|carotid artery segment medical ultrasound|sonography of carotid artery segment|carotid artery segment diagnostic sonography|carotid ultrasound imaging|carotid artery segment ultrasound imaging procedure	http://purl.obolibrary.org/obo/MAXO_0010218		
GO:1903553	biolink:BiologicalProcess	positive regulation of extracellular exosome assembly	Any process that activates or increases the frequency, rate or extent of extracellular vesicular exosome assembly.		hp.json	upregulation of extracellular vesicular exosome assembly|positive regulation of extracellular vesicular exosome assembly|up regulation of extracellular vesicular exosome assembly|up-regulation of extracellular vesicular exosome assembly|activation of extracellular vesicular exosome assembly	http://purl.obolibrary.org/obo/GO_1903553		
OBO:MAXO_0010219	biolink:NamedThing	pelvis ultrasonography	The use of ultrasound to produce images of structures in the pelvic region of trunk.		hp.json	pelvic region of trunk ultrasound examination|pelvic region of trunk medical ultrasound|sonography of pelvic region of trunk|pelvic region of trunk diagnostic sonography|pelvic sonography|pelvis sonography|pelvic region of trunk ultrasound imaging procedure|ultrasonography of pelvic region of trunk|pelvic region of trunk sonography|pelvic region of trunk ultrasound procedure	http://purl.obolibrary.org/obo/MAXO_0010219		
GO:1903552	biolink:BiologicalProcess	negative regulation of extracellular exosome assembly	Any process that stops, prevents or reduces the frequency, rate or extent of extracellular vesicular exosome assembly.		hp.json	down regulation of extracellular vesicular exosome assembly|inhibition of extracellular vesicular exosome assembly|down-regulation of extracellular vesicular exosome assembly|downregulation of extracellular vesicular exosome assembly|negative regulation of extracellular vesicular exosome assembly	http://purl.obolibrary.org/obo/GO_1903552		
UBERON:8410009	biolink:AnatomicalEntity	arteriole of anorectum	An arteriole that is located in the anorectum.		hp.json	anorectum arteriole	http://purl.obolibrary.org/obo/UBERON_8410009		
GO:1903561	biolink:CellularComponent	extracellular vesicle	Any vesicle that is part of the extracellular region.		hp.json	microparticle	http://purl.obolibrary.org/obo/GO_1903561		
GO:0061116	biolink:BiologicalProcess	ductus venosus closure	The morphogenesis process in which the ductus venosus changes to no longer permit blood flow after birth.		hp.json		http://purl.obolibrary.org/obo/GO_0061116		
GO:0061117	biolink:BiologicalProcess	negative regulation of heart growth	Any process that decreases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0061117		
OBO:MAXO_0010210	biolink:NamedThing	rectal ultrasonography	The use of ultrasound to produce images of structures in the rectum.		hp.json	sonography of rectum|rectum diagnostic sonography|rectum sonography|rectum ultrasound procedure|ultrasonography of rectum|rectum ultrasound examination|rectum medical ultrasound|rectum ultrasound imaging procedure	http://purl.obolibrary.org/obo/MAXO_0010210		
OBO:MAXO_0010211	biolink:NamedThing	scrotal ultrasonography	The use of ultrasound to produce images of structures in the scrotum.		hp.json	ultrasonography of scrotum|scrotum diagnostic sonography|scrotum ultrasound imaging procedure|sonography of scrotum|scrotum sonography|scrotum ultrasound procedure|scrotum ultrasound examination|scrotum medical ultrasound	http://purl.obolibrary.org/obo/MAXO_0010211		
UBERON:8410001	biolink:AnatomicalEntity	small intestine venule	Venule of villus of small intestine.		hp.json	venule of small intestine	http://purl.obolibrary.org/obo/UBERON_8410001		location_grouping
UBERON:8410002	biolink:AnatomicalEntity	small intestine lymphatic vessel	A lymphatic vessel that supplies the small intestine.		hp.json	lymphatic vessel of small intestine	http://purl.obolibrary.org/obo/UBERON_8410002		location_grouping
UBERON:8410004	biolink:AnatomicalEntity	small intestine arteriole	Arteriole of villus of small intestine.		hp.json	arteriole of small intestine|small intestine villus arteriole|arteriole of villus of small intestine	http://purl.obolibrary.org/obo/UBERON_8410004		location_grouping
GO:0000139	biolink:CellularComponent	Golgi membrane	The lipid bilayer surrounding any of the compartments of the Golgi apparatus.		hp.json		http://purl.obolibrary.org/obo/GO_0000139		
UBERON:8410008	biolink:AnatomicalEntity	venule of anorectum	A venule that is located in the anorectum.		hp.json	anorectum venule	http://purl.obolibrary.org/obo/UBERON_8410008		
GO:0002760	biolink:BiologicalProcess	positive regulation of antimicrobial humoral response	Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response.		hp.json	up regulation of antimicrobial humoral response|stimulation of antimicrobial humoral response|up-regulation of antimicrobial humoral response|activation of antimicrobial humoral response|upregulation of antimicrobial humoral response	http://purl.obolibrary.org/obo/GO_0002760		
GO:0002761	biolink:BiologicalProcess	regulation of myeloid leukocyte differentiation	Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0002761		
GO:0002762	biolink:BiologicalProcess	negative regulation of myeloid leukocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.		hp.json	down-regulation of myeloid leukocyte differentiation|down regulation of myeloid leukocyte differentiation|inhibition of myeloid leukocyte differentiation|downregulation of myeloid leukocyte differentiation	http://purl.obolibrary.org/obo/GO_0002762		
UBERON:8410000	biolink:AnatomicalEntity	duodeno-jejunal junction	The anatomical junction between the duodenum and the jejunum.	TA2:2952|FMA:15957|WikipediaVersioned:Duodenojejunal_flexure&oldid=937307798	hp.json	flexura duodenojejunalis|duodeno-jejunal flexure|duodenojejunal flexure|duodenojejunal junction	http://purl.obolibrary.org/obo/UBERON_8410000		human_reference_atlas
GO:0002763	biolink:BiologicalProcess	positive regulation of myeloid leukocyte differentiation	Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.		hp.json	activation of myeloid leukocyte differentiation|stimulation of myeloid leukocyte differentiation|upregulation of myeloid leukocyte differentiation|up-regulation of myeloid leukocyte differentiation|up regulation of myeloid leukocyte differentiation	http://purl.obolibrary.org/obo/GO_0002763		
GO:1903569	biolink:BiologicalProcess	positive regulation of protein localization to ciliary membrane	Any process that activates or increases the frequency, rate or extent of protein localization to ciliary membrane.		hp.json	positive regulation of protein localisation to ciliary membrane|positive regulation of protein localization in ciliary membrane|up regulation of protein localisation to ciliary membrane|upregulation of protein localization to ciliary membrane|up regulation of protein localization in ciliary membrane|activation of protein localisation to ciliary membrane|up-regulation of protein localisation to ciliary membrane|upregulation of protein localisation in ciliary membrane|up-regulation of protein localization in ciliary membrane|activation of protein localization in ciliary membrane|up regulation of protein localization to ciliary membrane|positive regulation of protein localisation in ciliary membrane|up-regulation of protein localization to ciliary membrane|up regulation of protein localisation in ciliary membrane|activation of protein localization to ciliary membrane|upregulation of protein localisation to ciliary membrane|upregulation of protein localization in ciliary membrane|up-regulation of protein localisation in ciliary membrane|activation of protein localisation in ciliary membrane	http://purl.obolibrary.org/obo/GO_1903569		
GO:1903568	biolink:BiologicalProcess	negative regulation of protein localization to ciliary membrane	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to ciliary membrane.		hp.json	inhibition of protein localization to ciliary membrane|down-regulation of protein localization to ciliary membrane|down regulation of protein localisation in ciliary membrane|downregulation of protein localisation to ciliary membrane|inhibition of protein localisation in ciliary membrane|down-regulation of protein localisation in ciliary membrane|negative regulation of protein localisation in ciliary membrane|downregulation of protein localization in ciliary membrane|down regulation of protein localisation to ciliary membrane|down regulation of protein localization in ciliary membrane|inhibition of protein localisation to ciliary membrane|downregulation of protein localization to ciliary membrane|negative regulation of protein localisation to ciliary membrane|inhibition of protein localization in ciliary membrane|down-regulation of protein localisation to ciliary membrane|down-regulation of protein localization in ciliary membrane|negative regulation of protein localization in ciliary membrane|downregulation of protein localisation in ciliary membrane|down regulation of protein localization to ciliary membrane	http://purl.obolibrary.org/obo/GO_1903568		
CHEBI:26288	biolink:ChemicalSubstance	propanediol			hp.json		http://purl.obolibrary.org/obo/CHEBI_26288		1_STAR
GO:0061140	biolink:BiologicalProcess	lung secretory cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a lung secretory cell. A lung secretory cell is a specialized epithelial cell of the lung that contains large secretory granules in its apical part.		hp.json		http://purl.obolibrary.org/obo/GO_0061140		
GO:1903567	biolink:BiologicalProcess	regulation of protein localization to ciliary membrane	Any process that modulates the frequency, rate or extent of protein localization to ciliary membrane.		hp.json	regulation of protein localisation in ciliary membrane|regulation of protein localisation to ciliary membrane|regulation of protein localization in ciliary membrane	http://purl.obolibrary.org/obo/GO_1903567		
GO:1903566	biolink:BiologicalProcess	positive regulation of protein localization to cilium	Any process that activates or increases the frequency, rate or extent of protein localization to cilium.		hp.json	upregulation of protein localization to cilium|up regulation of protein localization to cilium|up-regulation of protein localization to cilium|activation of protein localization to cilium	http://purl.obolibrary.org/obo/GO_1903566		
GO:0061141	biolink:BiologicalProcess	lung ciliated cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a lung ciliated cell. A lung ciliated cell is a specialized lung epithelial cell that contains cilia for moving substances released from lung secretory cells.		hp.json		http://purl.obolibrary.org/obo/GO_0061141		
GO:1903565	biolink:BiologicalProcess	negative regulation of protein localization to cilium	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cilium.		hp.json	down regulation of protein localization to cilium|inhibition of protein localization to cilium|down-regulation of protein localization to cilium|downregulation of protein localization to cilium	http://purl.obolibrary.org/obo/GO_1903565		
GO:1903564	biolink:BiologicalProcess	regulation of protein localization to cilium	Any process that modulates the frequency, rate or extent of protein localization to cilium.		hp.json		http://purl.obolibrary.org/obo/GO_1903564		
CHEBI:26284	biolink:ChemicalSubstance	propane-1,2-diols			hp.json		http://purl.obolibrary.org/obo/CHEBI_26284		1_STAR
GO:0014742	biolink:BiologicalProcess	positive regulation of muscle hypertrophy	Any process that activates or increases the frequency, rate or extent of muscle hypertrophy.		hp.json		http://purl.obolibrary.org/obo/GO_0014742		
GO:0014741	biolink:BiologicalProcess	negative regulation of muscle hypertrophy	Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy.		hp.json		http://purl.obolibrary.org/obo/GO_0014741		
GO:0061147	biolink:BiologicalProcess	endocardial endothelium development	The progression of the endocardial endothelium over time, from its initial formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.		hp.json		http://purl.obolibrary.org/obo/GO_0061147		
GO:0061148	biolink:BiologicalProcess	extracellular matrix organization involved in endocardium development	A process which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix of the endocardium. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.		hp.json	extracellular matrix organisation involved in endocardium development	http://purl.obolibrary.org/obo/GO_0061148		
GO:0014745	biolink:BiologicalProcess	negative regulation of muscle adaptation	Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation.		hp.json	negative regulation of muscle plasticity	http://purl.obolibrary.org/obo/GO_0014745		
GO:0014744	biolink:BiologicalProcess	positive regulation of muscle adaptation	Any process that activates or increases the frequency, rate or extent of muscle adaptation.		hp.json	positive regulation of muscle plasticity	http://purl.obolibrary.org/obo/GO_0014744		
GO:0014743	biolink:BiologicalProcess	regulation of muscle hypertrophy	Any process that modulates the frequency, rate or extent of muscle hypertrophy.		hp.json		http://purl.obolibrary.org/obo/GO_0014743		
CHEBI:38264	biolink:ChemicalSubstance	2-amino-3-methylpentanoic acid	A branched chain amino acid that consists of 3-methylpentanoic acid bearing an amino substituent at position 2.	CAS:443-79-8|CAS:443-79-8|PMID:10944265|Reaxys:1721790|KEGG:C16434	hp.json	2-amino-3-methylpentanoic acid	http://purl.obolibrary.org/obo/CHEBI_38264		3_STAR
CHEBI:38263	biolink:ChemicalSubstance	2-amino-3-hydroxybutanoic acid	An alpha-amino acid that is butanoic acid substituted by an amino group at position 2 and a hydroxy group at position 3.	Beilstein:1098902	hp.json	2-amino-3-hydroxybutanoic acid	http://purl.obolibrary.org/obo/CHEBI_38263		3_STAR
CHEBI:38261	biolink:ChemicalSubstance	imidazolidines			hp.json		http://purl.obolibrary.org/obo/CHEBI_38261		3_STAR
GO:0002775	biolink:BiologicalProcess	antimicrobial peptide production	The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.		hp.json		http://purl.obolibrary.org/obo/GO_0002775		gocheck_do_not_annotate
GO:0002776	biolink:BiologicalProcess	antimicrobial peptide secretion	The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.		hp.json		http://purl.obolibrary.org/obo/GO_0002776		
GO:1903579	biolink:BiologicalProcess	negative regulation of ATP metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process.		hp.json	down-regulation of ATP metabolic process|downregulation of ATP metabolism|down regulation of ATP metabolic process|down regulation of ATP metabolism|downregulation of ATP metabolic process|inhibition of ATP metabolism|inhibition of ATP metabolic process|down-regulation of ATP metabolism|negative regulation of ATP metabolism	http://purl.obolibrary.org/obo/GO_1903579		
GO:1903578	biolink:BiologicalProcess	regulation of ATP metabolic process	Any process that modulates the frequency, rate or extent of ATP metabolic process.		hp.json	regulation of ATP metabolism	http://purl.obolibrary.org/obo/GO_1903578		
GO:1903580	biolink:BiologicalProcess	positive regulation of ATP metabolic process	Any process that activates or increases the frequency, rate or extent of ATP metabolic process.		hp.json	upregulation of ATP metabolic process|up-regulation of ATP metabolism|activation of ATP metabolism|up-regulation of ATP metabolic process|upregulation of ATP metabolism|up regulation of ATP metabolic process|positive regulation of ATP metabolism|activation of ATP metabolic process|up regulation of ATP metabolism	http://purl.obolibrary.org/obo/GO_1903580		
GO:0061138	biolink:BiologicalProcess	morphogenesis of a branching epithelium	The process in which the anatomical structures of a branched epithelium are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0061138		
CHEBI:38275	biolink:ChemicalSubstance	pyrrolidinone			hp.json	pyrrolidinones	http://purl.obolibrary.org/obo/CHEBI_38275		3_STAR
dc:contributor	biolink:NamedThing	contributor		http://purl.org/dc/elements/1.1/contributor	hp.json		http://purl.org/dc/elements/1.1/contributor		
HP:0011494	biolink:PhenotypicFeature	Generalized opacification of the cornea	Generalized reduced transparency of the stroma of the cornea.	UMLS:C4021147	hp.json	Generalised opacification of the cornea	http://purl.obolibrary.org/obo/HP_0011494		
HP:0011495	biolink:PhenotypicFeature	Abnormal corneal epithelium morphology	Abnormality of the corneal epithelium, that is of the epithelial tissue that covers the front of the cornea.	UMLS:C4023326	hp.json	Abnormality of corneal epithelium	http://purl.obolibrary.org/obo/HP_0011495		
HP:0011496	biolink:PhenotypicFeature	Corneal neovascularization	Ingrowth of new blood vessels into the cornea.	UMLS:C0085109|MSH:D016510|SNOMEDCT_US:19161004	hp.json	New blood vessel formation in cornea|Corneal pannus|Limbal neovascularization|Corneal neovascularisation|Corneal vascularization	http://purl.obolibrary.org/obo/HP_0011496		
HP:0011497	biolink:PhenotypicFeature	Iris neovascularization	New growth of vessels on the surface of the iris.	UMLS:C0154916|SNOMEDCT_US:51995000	hp.json	Neovascularization of the iris|New blood vessel formation in iris	http://purl.obolibrary.org/obo/HP_0011497		
OBO:MAXO_0000860	biolink:NamedThing	assessment of fetal presentation	A series of maneuvers to determine the position and presenting part of the fetus with respect to the maternal pelvic canal in preparation for labor and the birth process.	NCIT:C92737	hp.json	fetal position assessment|fetal presentation assessment	http://purl.obolibrary.org/obo/MAXO_0000860		
HP:0011498	biolink:PhenotypicFeature	obsolete Partial aniridia			hp.json		http://purl.obolibrary.org/obo/HP_0011498		
HP:0011499	biolink:PhenotypicFeature	Mydriasis	Abnormal dilatation of the iris.	MSH:D015878|SNOMEDCT_US:37125009|UMLS:C0026961	hp.json	Dilated pupil	http://purl.obolibrary.org/obo/HP_0011499		hposlim_core
CHEBI:89843	biolink:ChemicalSubstance	methylsuccinic acid	A racemate comprising equimolar amounts of (R)- and (S)-methylsuccinic acid	CAS:498-21-5|MetaCyc:CPD-2461|LIPID_MAPS_instance:LMFA01170119|HMDB:HMDB0001844|Reaxys:1722946|CAS:498-21-5	hp.json	rac-2-methylbutanedioic acid|Methylbutanedioic acid|2-methyl-butanedioic acid|Pyrotartaric acid|(RS)-methylsuccinic acid|Methyl Succinic acid|(+-)-methylsuccinic acid|2-methylbutanedioic acid|1,2-Propanedicarboxylic acid|(RS)-2-methylbutanedioic acid	http://purl.obolibrary.org/obo/CHEBI_89843		3_STAR
HP:0011490	biolink:PhenotypicFeature	Abnormal Descemet membrane morphology	Abnormality of Descemet's membrane, which is the basement membrane of the corneal endothelium.	UMLS:C4023330	hp.json	Abnormality of Descemet's membrane	http://purl.obolibrary.org/obo/HP_0011490		
HP:0011491	biolink:PhenotypicFeature	Reduced number of corneal endothelial cells	A reduction in the number of corneal endothelial cells.	UMLS:C4023329	hp.json		http://purl.obolibrary.org/obo/HP_0011491		
HP:0011492	biolink:PhenotypicFeature	Abnormal corneal stroma morphology	An abnormality of the stroma of cornea, also known as the substantia propria of cornea.	UMLS:C4023328	hp.json	Abnormality of corneal stroma	http://purl.obolibrary.org/obo/HP_0011492		
HP:0011493	biolink:PhenotypicFeature	Central opacification of the cornea	Reduced transparency of the central portion of the corneal stroma.	UMLS:C4023327	hp.json		http://purl.obolibrary.org/obo/HP_0011493		
OBO:MAXO_0000865	biolink:NamedThing	protein measurement in blood	The determination of the amount of protein present in blood.		hp.json	protein blood assessment|blood protein test	http://purl.obolibrary.org/obo/MAXO_0000865		
GO:0036194	biolink:CellularComponent	muscle cell projection	A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.		hp.json	muscle arm|myopodia|myocyte projection	http://purl.obolibrary.org/obo/GO_0036194		
OBO:MAXO_0000862	biolink:NamedThing	obsolete fetal Doppler velocimetry	An antenatal ultrasonographic method that measures blood flow velocity through either maternal or fetal vessels.	NCIT:C114080	hp.json	Doppler velocimetry	http://purl.obolibrary.org/obo/MAXO_0000862		
OBO:MAXO_0000863	biolink:NamedThing	fetal pulse oximetry	A method to assess fetal oxygenation status during labor and delivery using a noninvasive reflectance pulse oximeter.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000863		
GO:0036195	biolink:CellularComponent	muscle cell projection membrane	The portion of the plasma membrane surrounding a muscle cell projection.		hp.json		http://purl.obolibrary.org/obo/GO_0036195		
OBO:MAXO_0000869	biolink:NamedThing	obstetric abdominal examination	A systemic evaluation of the abdomen using visual inspection, palpation, and percussion during pregnancy to determine the health of the mother and fetus.		hp.json	pregnant abdomen examination|abdominal examination during pregnancy	http://purl.obolibrary.org/obo/MAXO_0000869		
HP:0011483	biolink:PhenotypicFeature	Anterior synechiae of the anterior chamber	Adhesions between the iris and the cornea.	SNOMEDCT_US:70992005|UMLS:C0152252	hp.json	Anterior synechiae|Iridocorneal synechia|Cornea-iris adhesion	http://purl.obolibrary.org/obo/HP_0011483		
HP:0011484	biolink:PhenotypicFeature	Posterior synechiae of the anterior chamber	Adhesions between the iris and the lens.	SNOMEDCT_US:111512005|UMLS:C0152253	hp.json	Iridolenticular adhesions|Posterior synechiae	http://purl.obolibrary.org/obo/HP_0011484		
HP:0011485	biolink:PhenotypicFeature	Corneolenticular adhesion	Developmental abnormality in which the lens and cornea are not separated.	UMLS:C4023334	hp.json		http://purl.obolibrary.org/obo/HP_0011485		
HP:0011486	biolink:PhenotypicFeature	Abnormality of corneal thickness	An abnormal anteroposterior thickness of the cornea.	UMLS:C4023333	hp.json		http://purl.obolibrary.org/obo/HP_0011486		
HP:0011487	biolink:PhenotypicFeature	Increased corneal thickness	A increased anteroposterior thickness of the cornea.	UMLS:C3810451	hp.json		http://purl.obolibrary.org/obo/HP_0011487		
OBO:MAXO_0000850	biolink:NamedThing	total protein measurement	A quantitative measurement of total protein present in the sample, usually serum or urine.	NCIT:C64858	hp.json		http://purl.obolibrary.org/obo/MAXO_0000850		
HP:0011488	biolink:PhenotypicFeature	Abnormal corneal endothelium morphology	Abnormality of the corneal endothelium, that is, the single layer of cells on the inner surface of the cornea.	UMLS:C4023332	hp.json	Abnormality of corneal endothelium	http://purl.obolibrary.org/obo/HP_0011488		
HP:0011489	biolink:PhenotypicFeature	Abnormal migration of corneal endothelium	Abnormal migration of corneal endothelium.	UMLS:C4023331	hp.json		http://purl.obolibrary.org/obo/HP_0011489		
HP:0011480	biolink:PhenotypicFeature	Unilateral microphthalmos	A developmental anomaly characterized by abnormal smallness of one eye.	UMLS:C3640024|UMLS:C4280323	hp.json	Abnormally small eyeball on one side|Unilateral nanophthalmos	http://purl.obolibrary.org/obo/HP_0011480		
HP:0011481	biolink:PhenotypicFeature	Abnormal lacrimal duct morphology	An abnormality of the lacrimal duct, a duct that drain tears from the conjunctiva, via the lacrimal puncta, into the lacrimal sac.	UMLS:C1858567	hp.json	Abnormality of the lacrimal duct|Abnormality of the lacrimal canaliculus	http://purl.obolibrary.org/obo/HP_0011481		
HP:0011482	biolink:PhenotypicFeature	Abnormal lacrimal gland morphology	Abnormality of the lacrimal gland, i.e., of the almond-shaped gland that secretes the aqueous layer of the tear film for each eye.	UMLS:C4023336	hp.json	Abnormality of the lacrimal gland	http://purl.obolibrary.org/obo/HP_0011482		
OBO:MAXO_0000859	biolink:NamedThing	fetal examination	A test or diagnostic examination to assess the health status and well being of the fetus.		hp.json	foetal examination|fetal assessment|fetal exam	http://purl.obolibrary.org/obo/MAXO_0000859		
OBO:MAXO_0000853	biolink:NamedThing	serum total protein measurement	A quantitative measurement of the total amount of protein present in a sample of serum.	NCIT:C61033	hp.json		http://purl.obolibrary.org/obo/MAXO_0000853		
OBO:MAXO_0000854	biolink:NamedThing	haptoglobin measurement	The determination of the amount of haptoglobin present in the sample.	NCIT:C74740	hp.json	haptoglobin test|haptoglobin assessment|haptog measurement|haptoglobin protein measurement	http://purl.obolibrary.org/obo/MAXO_0000854		
OBO:MAXO_0000851	biolink:NamedThing	urine protein measurement	The determination of the amount of protein present in urine.	NCIT:C74760	hp.json	urine protein testing|urine protein test|protein urine assessment|urine protein assessment	http://purl.obolibrary.org/obo/MAXO_0000851		
OBO:MAXO_0000852	biolink:NamedThing	24-hour urine collection	The measurement of the total protein present in a urine sample that was collected over a period of 24 hours.	NCIT:C135567	hp.json	24 hour urine for total protein|24-hour urine protein test	http://purl.obolibrary.org/obo/MAXO_0000852		
OBO:MAXO_0000858	biolink:NamedThing	glucose tolerance test	A test that involves administration of a know quantity of glucose as a means of screening for glucose intolerance or diabetes mellitus. Typically a baseline (fasting plasma or serum glucose) is drawn prior to the administration of the glucose bolus.  Serial plasma glucose levels are obtained (e.g. 30min, 1hr, 2hr, 3hr) and a plot of plasma glucose versus time is created.  Comparison of these values against standardized results can be used in establishing the diagnosis of glucose intolerance or diabetes mellitus.	NCIT:C45946	hp.json		http://purl.obolibrary.org/obo/MAXO_0000858		
OBO:MAXO_0000855	biolink:NamedThing	hemoglobin electrophoresis test	Determination of the types of normal or abnormal types of hemoglobin in the blood. Some types of hemoglobin are associated with sickle cell disease or anemia.		hp.json	sickle cell screen|Hb electrophoresis measurement|Hb ELP|hemoglobinopathy evaluation|hemoglobin evaluation|hemoglobin fractionation	http://purl.obolibrary.org/obo/MAXO_0000855		
OBO:MAXO_0000856	biolink:NamedThing	serum PAPP-A measurement	Determination of serum levels of pregnancy-associated plasma protein A (PAPP-A). Maternal levels of PAPP-A increase throughout the pregnancy. Low levels during pregnancy are associated with Down syndrome and trisomy 18.		hp.json	pregnancy-associated plasma protein A test	http://purl.obolibrary.org/obo/MAXO_0000856		
OBO:MAXO_0010209	biolink:NamedThing	pancreatic ultrasonography	The use of ultrasound to produce images of structures in the pancreas.		hp.json	pancreas medical ultrasound|pancreas ultrasound imaging procedure|pancreas sonography|pancreas diagnostic sonography|sonography of pancreas|pancreas ultrasound procedure|pancreas ultrasound examination|ultrasonography of pancreas	http://purl.obolibrary.org/obo/MAXO_0010209		
HP:0011472	biolink:PhenotypicFeature	Abnormality of small intestinal villus morphology		UMLS:C4023341	hp.json	Abnormal shape of small intestinal villus	http://purl.obolibrary.org/obo/HP_0011472		
HP:0011473	biolink:PhenotypicFeature	Villous atrophy	The enteric villi are atrophic or absent.	UMLS:C2677378|UMLS:C4020747|SNOMEDCT_US:75581001|UMLS:C0554101|SNOMEDCT_US:275403002|UMLS:C1833058|UMLS:C1859541|UMLS:C0267456	hp.json	Villous degeneration|Atrophy of small intestinal villi|Duodenal villous atrophy|Variable degree of villous atrophy|Biopsy shows villous atrophy|Small intestine biopsy shows villous atrophy	http://purl.obolibrary.org/obo/HP_0011473		hposlim_core
HP:0011474	biolink:PhenotypicFeature	Childhood onset sensorineural hearing impairment	Sensorineural hearing impairment with childhood onset.	UMLS:C4023340	hp.json		http://purl.obolibrary.org/obo/HP_0011474		
HP:0011475	biolink:PhenotypicFeature	Persistent stapedial artery	Persistence of the stapedial artery, which normally regresses during embryonic life.	UMLS:C4023339	hp.json		http://purl.obolibrary.org/obo/HP_0011475		
HP:0011476	biolink:PhenotypicFeature	Profound sensorineural hearing impairment	Complete loss of hearing related to a sensorineural defect.	UMLS:C4023338	hp.json		http://purl.obolibrary.org/obo/HP_0011476		
HP:0011477	biolink:PhenotypicFeature	Upbeat nystagmus	In primary position, the eyes drift slowly downward and then spontaneously beat upward. Upward gaze accentuates the nystagmus. The associated oscillopsias are often very irritating, but the symptoms are usually transient.	SNOMEDCT_US:307677002|UMLS:C0585545	hp.json		http://purl.obolibrary.org/obo/HP_0011477		
HP:0011478	biolink:PhenotypicFeature	True anophthalmia	Absence of globe, optic nerve, chiasm and optic tracts. No evidence of ocular tissue on MRI scan or examination.	UMLS:C2675590	hp.json	Completely missing eyeball|Total anophthalmia|Complete anophthalmia	http://purl.obolibrary.org/obo/HP_0011478		
OBO:MAXO_0000880	biolink:NamedThing	indirect bilirubin measurement for assessment of liver function	A measurement of the unconjugated or non-water-soluble bilirubin in a biological specimen to assess liver function.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000880		
HP:0011479	biolink:PhenotypicFeature	Abnormal lacrimal punctum morphology	An abnormality of the lacrimal punctum, an opening on the eyelid close to the medial canthus that drains tears from the conjunctival sac into the lacrimal duct in the same eyelid.	UMLS:C4023337	hp.json	Abnormality of the lacrimal punctum	http://purl.obolibrary.org/obo/HP_0011479		
OBO:MAXO_0010201	biolink:NamedThing	uterine ultrasonography	The use of ultrasound to produce images of structures in the body of uterus.		hp.json	body of uterus sonography|ultrasonography of body of uterus|body of uterus ultrasound procedure|body of uterus ultrasound examination|body of uterus medical ultrasound|body of uterus ultrasound imaging procedure|sonography of body of uterus|body of uterus diagnostic sonography	http://purl.obolibrary.org/obo/MAXO_0010201		
OBO:MAXO_0010202	biolink:NamedThing	breast ultrasonography	The use of ultrasound to produce images of structures in the breast.		hp.json	breast ultrasound imaging procedure|sonography of breast|breast diagnostic sonography|breast sonography|ultrasonography of breast|breast ultrasound procedure|breast ultrasound examination|breast medical ultrasound	http://purl.obolibrary.org/obo/MAXO_0010202		
OBO:MAXO_0010203	biolink:NamedThing	echocardiography	The use of ultrasound to produce images of structures in the heart.		hp.json	echocardiogram procedure|sonography of heart|heart sonography|heart ultrasound procedure|heart ultrasound examination|cardiac echo procedure|heart medical ultrasound|ultrasonography of heart|echo procedure|heart ultrasound imaging procedure|heart diagnostic sonography	http://purl.obolibrary.org/obo/MAXO_0010203		
CHEBI:16919	biolink:ChemicalSubstance	creatine	A glycine derivative having methyl and amidino groups attached to the nitrogen.	Wikipedia:Creatine|PMID:22521466|PMID:21556832|PMID:22038587|MetaCyc:CREATINE|DrugBank:DB00148|PDBeChem:CRN|PMID:11356982|CAS:57-00-1|CAS:57-00-1|PMID:17416441|PMID:7752905|PMID:22196490|PMID:19741514|PMID:19082141|PMID:12878267|HMDB:HMDB0000064|PMID:17253521|PMID:21660517|PMID:22465051|PMID:18555535|Beilstein:907175|PMID:22347384|PMID:19651674|PMID:21698493|PMID:22252611|PMID:22429992|Reaxys:907175|PMID:11867929|KEGG:C00300|PMID:19968328|Gmelin:240513|PMID:22101931|PMID:12184144|PMID:22422801|PMID:22386973|PMID:16445883|CAS:57-00-1|PMID:17190852|Chemspider:566|Drug_Central:4661|PMID:12085493|PMID:11483809	hp.json	N-(aminoiminomethyl)-N-methylglycine|Methylglycocyamine|(alpha-methylguanido)acetic acid|N-carbamimidoyl-N-methylglycine|Creatin|Creatine|(N-methylcarbamimidamido)acetic acid|(alpha-methylguanido)acetic acid|alpha-Methylguanidino acetic acid|N-amidinosarcosine|N-[(E)-AMINO(IMINO)METHYL]-N-METHYLGLYCINE|N-[amino(imino)methyl]-N-methylglycine|((amino(imino)methyl)(methyl)amino)acetic acid|Kreatin|N-methyl-N-guanylglycine|N-Methyl-N-guanylglycine	http://purl.obolibrary.org/obo/CHEBI_16919		3_STAR
OBO:MAXO_0010204	biolink:NamedThing	liver ultrasonography	The use of ultrasound to produce images of structures in the liver.		hp.json	sonography of liver|liver sonography|liver ultrasound procedure|liver ultrasound examination|liver medical ultrasound|ultrasonography of liver|liver ultrasound imaging procedure|liver diagnostic sonography	http://purl.obolibrary.org/obo/MAXO_0010204		
OBO:MAXO_0010205	biolink:NamedThing	lung ultrasonography	The use of ultrasound to produce images of structures in the lung.		hp.json	lung ultrasound procedure|lung diagnostic sonography|sonography of lung|lung ultrasound examination|lung medical ultrasound|ultrasonography of lung|lung ultrasound imaging procedure|lung sonography	http://purl.obolibrary.org/obo/MAXO_0010205		
OBO:MAXO_0010206	biolink:NamedThing	lymph node ultrasonography	The use of ultrasound to produce images of structures in the lymph node.		hp.json	lymph node ultrasound imaging procedure|lymph node sonography|lymph node ultrasound procedure|sonography of lymph node|lymph node diagnostic sonography|lymph node ultrasound examination|lymph node medical ultrasound|ultrasonography of lymph node	http://purl.obolibrary.org/obo/MAXO_0010206		
OBO:MAXO_0010207	biolink:NamedThing	musculoskeletal ultrasonography	The use of ultrasound to produce images of structures in the musculoskeletal system.		hp.json	ultrasonography of musculoskeletal system|musculoskeletal system sonography|musculoskeletal system ultrasound procedure|musculoskeletal system ultrasound examination|musculoskeletal system medical ultrasound|musculoskeletal system ultrasound imaging procedure|sonography of musculoskeletal system|musculoskeletal system diagnostic sonography	http://purl.obolibrary.org/obo/MAXO_0010207		
HP:0011470	biolink:PhenotypicFeature	Nasogastric tube feeding in infancy	Feeding problem necessitating nasogastric tube feeding.	UMLS:C4023343	hp.json		http://purl.obolibrary.org/obo/HP_0011470		
OBO:MAXO_0010208	biolink:NamedThing	neck ultrasonography	The use of ultrasound to produce images of structures in the neck.		hp.json	neck ultrasound procedure|neck ultrasound examination|neck medical ultrasound|sonography of neck|neck diagnostic sonography|neck ultrasound imaging procedure|ultrasonography of neck|neck sonography	http://purl.obolibrary.org/obo/MAXO_0010208		
HP:0011471	biolink:PhenotypicFeature	Gastrostomy tube feeding in infancy	Feeding problem necessitating gastrostomy tube feeding.	UMLS:C4023342|UMLS:C4020748	hp.json	PEG-fed in infancy	http://purl.obolibrary.org/obo/HP_0011471		
GO:0036179	biolink:BiologicalProcess	osteoclast maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes.		hp.json	chondroclast maturation	http://purl.obolibrary.org/obo/GO_0036179		
OBO:MAXO_0010200	biolink:NamedThing	transabdominal ultrasonography	A method of ultrasound imaging in which the ultrasound probe is pressed against the skin of the abdomen in order to create an image of the abdominal organs.	NCIT:C71375	hp.json	TUS|diagnostic transabdominal ultrasound|transabdominal sonography|abdomen sonography|ultrasonography of abdomen|abdomen ultrasound procedure|medical transabdominal ultrasound|abdomen diagnostic sonography|abdomen ultrasound examination|transabdominal ultrasound|sonography of abdomen|abdomen medical ultrasound|abdomen ultrasound imaging procedure	http://purl.obolibrary.org/obo/MAXO_0010200		
GO:0120111	biolink:CellularComponent	neuron projection cytoplasm	All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection.		hp.json		http://purl.obolibrary.org/obo/GO_0120111		
OBO:MAXO_0000886	biolink:NamedThing	kidney function testing	A laboratory procedure that evaluates the kidney function.	NCIT:C74972	hp.json	rental function test	http://purl.obolibrary.org/obo/MAXO_0000886		
OBO:MAXO_0000887	biolink:NamedThing	glomerular filtration rate test	A measurement of the volume of fluid filtered from the renal glomerular capillaries into the Bowman's capsule per unit time.		hp.json	GFR test	http://purl.obolibrary.org/obo/MAXO_0000887		
OBO:MAXO_0000888	biolink:NamedThing	estimated glomerular filtration rate calculation	An estimated rate of glomerular filtration is calculated from blood creatinine test, age, body size and gender.		hp.json	eGFR test	http://purl.obolibrary.org/obo/MAXO_0000888		
PR:000001408	biolink:Protein	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	An ADP-ribosyl cyclase that is a translation product of the human CD38 gene or a 1:1 ortholog thereof.	IUPHARobj:2766	hp.json	CD38|2'-phospho-cyclic-ADP-ribose transferase|ADP-ribosyl cyclase 1|cyclic ADP-ribose hydrolase 1|T10|cADPr hydrolase 1|ADPRC 1|2'-phospho-ADP-ribosyl cyclase|I-19|NIM-R5 antigen|2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase	http://purl.obolibrary.org/obo/PR_000001408		
HP:0011461	biolink:PhenotypicFeature	Fetal onset	Onset prior to birth but after 8 weeks of embryonic development (corresponding to a gestational age of 10 weeks).	UMLS:C4023347	hp.json	Foetal onset	http://purl.obolibrary.org/obo/HP_0011461		
HP:0011462	biolink:PhenotypicFeature	Young adult onset	Onset of disease at the age of between 16 and 40 years.	UMLS:C3554568	hp.json		http://purl.obolibrary.org/obo/HP_0011462		
HP:0011463	biolink:PhenotypicFeature	Childhood onset	Onset of disease at the age of between 1 and 5 years.	UMLS:C1837352	hp.json	Symptoms begin in childhood	http://purl.obolibrary.org/obo/HP_0011463		
HP:0011464	biolink:PhenotypicFeature	Aganglionosis of the small intestine	A lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) affecting the small intestine.	UMLS:C4023346	hp.json		http://purl.obolibrary.org/obo/HP_0011464		
OBO:MAXO_0000871	biolink:NamedThing	obstetric cervical examination	A systemic evaluation of the cervix during pregnancy to determine dilation and effacement of the cervix, cervical position and consistancy, and fetal position.		hp.json	pregnant cervical exam|cervical exam while pregnant|obstetric examination of the cervix.	http://purl.obolibrary.org/obo/MAXO_0000871		
HP:0011465	biolink:PhenotypicFeature	Duodenal aganglionosis	A lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) affecting the duodenum.	UMLS:C4023345	hp.json		http://purl.obolibrary.org/obo/HP_0011465		
GO:0051702	biolink:BiologicalProcess	biological process involved in interaction with symbiont	An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.		hp.json	interaction with symbiont	http://purl.obolibrary.org/obo/GO_0051702		
HP:0011466	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the gallbladder	Absence or underdevelopment of the gallbladder.	UMLS:C4023344	hp.json	Absent/small gallbladder|Absent/underdeveloped gallbladder	http://purl.obolibrary.org/obo/HP_0011466		
OBO:MAXO_0000872	biolink:NamedThing	cancer screening breast examination	An evaluation of the breast using visual inspection, palpation, and percussion for the specific purpose of identifying breast changes which may be cancer.		hp.json	cancer breast exam	http://purl.obolibrary.org/obo/MAXO_0000872		
HP:0011467	biolink:PhenotypicFeature	Absent gallbladder	A developmental defect in which the gallbladder fails to form.	SNOMEDCT_US:86507001|UMLS:C0266251|MSH:C562564	hp.json	Agenesis of the gallbladder|Aplasia of the gallbladder|Absent gallbladder	http://purl.obolibrary.org/obo/HP_0011467		
HP:0011468	biolink:PhenotypicFeature	Facial tics	Sudden, repetitive, nonrhythmic motor movements (spasms), involving the eyes and muscles of the face.	UMLS:C4280325|SNOMEDCT_US:32402008|UMLS:C4280324|UMLS:C0338467|UMLS:C0858722|UMLS:C0278151|SNOMEDCT_US:230335009	hp.json	Twitching of facial muscles|Jerking of facial muscles|Cramping of facial muscles|Involuntary facial muscle spasms|Muscle spasm of face|Spasms of facial muscles|Mimic spasms|Facial spasms|Facial tics|Myoclonus of facial muscles	http://purl.obolibrary.org/obo/HP_0011468		
OBO:MAXO_0000870	biolink:NamedThing	pregnancy HCG test	A quantitative measurement of the amount of human chorionic gonadotropin present in urine or serum for the purpose of determining whether the patient is pregnant.		hp.json	HCG pregnancy test	http://purl.obolibrary.org/obo/MAXO_0000870		
GO:0051707	biolink:BiologicalProcess	response to other organism	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.		hp.json		http://purl.obolibrary.org/obo/GO_0051707		
GO:0051704	biolink:BiologicalProcess	multi-organism process	A biological process which involves another organism of the same or different species.		hp.json	physiological interaction with other organism|physiological interaction between organisms|interaction between organisms	http://purl.obolibrary.org/obo/GO_0051704		gocheck_do_not_annotate|goslim_pir
HP:0011460	biolink:PhenotypicFeature	Embryonal onset	Onset of disease at up to 8 weeks following fertilization (corresponding to 10 weeks of gestation).	UMLS:C4023348	hp.json		http://purl.obolibrary.org/obo/HP_0011460		
CHEBI:63248	biolink:ChemicalSubstance	oxidising agent	A substance that removes electrons from another reactant in a redox reaction.		hp.json	oxidizer|oxidizing agent|oxidizing agents|oxidizers|oxidants|oxidiser|oxidising agents|oxidisers|oxidant	http://purl.obolibrary.org/obo/CHEBI_63248		3_STAR
HP:0011469	biolink:PhenotypicFeature	Nasal regurgitation	Regurgitation of milk through the nose.	SNOMEDCT_US:85023004|UMLS:C0232608	hp.json		http://purl.obolibrary.org/obo/HP_0011469		
OBO:MAXO_0000875	biolink:NamedThing	5'-nucleotidase measurement for liver function	The determination of the amount of 5'-nucleotidase present in the sample to assess liver function.		hp.json	5'-nucleotidase test for liver function assessment|liver function 5'-nucleotidase test|liver function 5'-nucleotidase measurement	http://purl.obolibrary.org/obo/MAXO_0000875		
OBO:MAXO_0000876	biolink:NamedThing	alkaline phosphatase measurement for liver function	The determination of the amount of alkaline phosphatase present in the sample for assessment of liver function.		hp.json	liver function alkaline phosphatase measurement|liver function alk phos test|alkaline phosphatase measurement for liver function assessment	http://purl.obolibrary.org/obo/MAXO_0000876		
OBO:MAXO_0000873	biolink:NamedThing	hearing examination	A test that evaluates of the sensitivity of a person's sense of hearing and is used to determine a person's hearing sensitivity at different frequencies.		hp.json	hearing test|hearing assessment|hearing exam	http://purl.obolibrary.org/obo/MAXO_0000873		
GO:0036161	biolink:NamedThing	calcitonin secretion			hp.json		http://purl.obolibrary.org/obo/GO_0036161		
OBO:MAXO_0000874	biolink:NamedThing	albumin test for liver function	The determination of the amount of albumin (human) present in the sample in order to assess the liver's function.		hp.json	liver function albumin test|albumin test for liver function assessment	http://purl.obolibrary.org/obo/MAXO_0000874		
OBO:MAXO_0000879	biolink:NamedThing	total bilirubin measurement for assessment of liver function	The measurement of the total amount of bilirubin present in a particular substrate in order to assess liver function. The substrate most often tested is blood, but other fluids extracted from the body may be used periodically depending on the purpose of the test.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000879		
OBO:MAXO_0000877	biolink:NamedThing	calcium assessment for liver function	A quantitative measurement of the amount of calcium present in a sample, usually serum or urine for the assessment of liver function.		hp.json	liver function calcium test|calcium test for liver function assessement	http://purl.obolibrary.org/obo/MAXO_0000877		
OBO:MAXO_0000878	biolink:NamedThing	lactate dehydrogenase measurement for liver assessment	The determination of the amount of lactate dehydrogenase present in the sample to assess liver function.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000878		
GO:0051716	biolink:BiologicalProcess	cellular response to stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.		hp.json		http://purl.obolibrary.org/obo/GO_0051716		gocheck_do_not_manually_annotate
OBO:MAXO_0000828	biolink:NamedThing	total iron binding capacity measurement	The determination of the saturation of iron binding sites on serum transferrin proteins.	NCIT:C74718	hp.json	total iron binding content measurement|IBCT|TIBC	http://purl.obolibrary.org/obo/MAXO_0000828		
OBO:MAXO_0000829	biolink:NamedThing	blood cell measurement	A measurement of size, shape, number, or other parameter of blood cells in order to diagnose or treat a patient.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000829		
OBO:MAXO_0000826	biolink:NamedThing	serum iron measurement	A quantitative measurement of the amount of iron in serum.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000826		
OBO:MAXO_0000827	biolink:NamedThing	serum ferritin measurement	A quantitative measurement determining the amount of ferritin in serum as an indicator of iron metabolism.		hp.json	serum ferritin level measurement	http://purl.obolibrary.org/obo/MAXO_0000827		
OBO:MAXO_0000820	biolink:NamedThing	bile specimen collection	Collecting of bile for clinical use.		hp.json	collection of bile specimen|bile collection	http://purl.obolibrary.org/obo/MAXO_0000820		
OBO:MAXO_0000821	biolink:NamedThing	blood typing procedure	A procedure to tell what a patient's blood type and cell surface markers are.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000821		
OBO:MAXO_0000824	biolink:NamedThing	hemoglobin measurement	A quantitative measurement of the amount of hemoglobin present in a sample.	NCIT:C64848	hp.json	HGB measurement	http://purl.obolibrary.org/obo/MAXO_0000824		
OBO:MAXO_0000825	biolink:NamedThing	reticulocyte count	The determination of the number of reticulocytes in a blood sample.	NCIT:C51947|PMID:29763080	hp.json		http://purl.obolibrary.org/obo/MAXO_0000825		
OBO:MAXO_0000822	biolink:NamedThing	ABO blood typing procedure	A procedured performed to determine the antigens patient's red blood cells (RBCs) that correspond to the four main blood groups: A, B, O, and AB.		hp.json	ABO blood type testing	http://purl.obolibrary.org/obo/MAXO_0000822		
OBO:MAXO_0000823	biolink:NamedThing	Rh factor blood typing procedure	Testing to determine whether the protien Rhesus (Rh) factor is present on patient's red blood cells. If the protein is present, the patient is said to be Rh positive. If the protein is not present, the patient is Rh negative.		hp.json	Rhesus factor blood testing|Rh factor blood testing	http://purl.obolibrary.org/obo/MAXO_0000823		
UBERON:0035371	biolink:AnatomicalEntity	retroperitoneal lymph node	A lymph node located in the retroperitoneal space.	FMA:16694|NCIT:C98189	hp.json	retroperitoneal node	http://purl.obolibrary.org/obo/UBERON_0035371		
GO:0051726	biolink:BiologicalProcess	regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.		hp.json	cell cycle arrest|cell cycle regulation|regulation of cell cycle arrest|arrest of mitotic cell cycle progression|regulation of progression through cell cycle|mitotic cell cycle arrest|positive regulation of cell cycle arrest|control of cell cycle progression|modulation of cell cycle progression|regulation of cell cycle progression|negative regulation of cell cycle arrest|cell cycle regulator|cell cycle modulation|tumor suppressor	http://purl.obolibrary.org/obo/GO_0051726		goslim_yeast
GO:0036145	biolink:BiologicalProcess	dendritic cell homeostasis	The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.		hp.json	DC homeostasis	http://purl.obolibrary.org/obo/GO_0036145		
OBO:MAXO_0000817	biolink:NamedThing	hepatitis C screening	Screening for hepatitis C antibodies to determine if a patient has immunity to hepatitis C.		hp.json	hep C testing	http://purl.obolibrary.org/obo/MAXO_0000817		
OBO:MAXO_0000815	biolink:NamedThing	chlamydia screening	Testing to determine if the patient has a chlamydia bacterial infection.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000815		
OBO:MAXO_0000816	biolink:NamedThing	gonorrhea testing	Testing for the sexually transmitted disease gonorrhea.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000816		
OBO:MAXO_0000819	biolink:NamedThing	blood specimen collection	Collecting of blood for clinical use.		hp.json	collection of blood specimen|blood collection	http://purl.obolibrary.org/obo/MAXO_0000819		
PR:000001479	biolink:Protein	low affinity immunoglobulin gamma Fc region receptor II	An immunoglobulin gamma Fc receptor II/III/IV that is a translation product of the mouse Fcgr2 gene or a 1:1 ortholog thereof.		hp.json	Fc gamma receptor IIB|lymphocyte antigen 17|Fc-gamma RII|IgG Fc receptor II beta|CD32|ly-17|Fc-gamma-RIIB|FcRII|Fcgr2b|Fcgr2	http://purl.obolibrary.org/obo/PR_000001479		
OBO:MAXO_0000810	biolink:NamedThing	rubella antibody titer testing	Testing to determine whether a patient has sufficient antibodies to be protected from rubella virus or to verify infection.		hp.json	rubella testing	http://purl.obolibrary.org/obo/MAXO_0000810		
OBO:MAXO_0000813	biolink:NamedThing	hepatitis B surface antigen testing	Testing to detect hepatitis B viral antigens and an active hepatitis B infection.		hp.json	HBsAg testing	http://purl.obolibrary.org/obo/MAXO_0000813		
OBO:MAXO_0000814	biolink:NamedThing	HIV screening	Testing a patient for the antibodies to the human immunodeficiency virus (HIV).		hp.json	HIV testing	http://purl.obolibrary.org/obo/MAXO_0000814		
OBO:MAXO_0000811	biolink:NamedThing	varicella testing	Testing to diagnose primary VZV infection (varicella) as well as reactivation (herpes zoster).		hp.json	chickenpox testing|VZV testing|varicella-zoster virus testing	http://purl.obolibrary.org/obo/MAXO_0000811		
OBO:MAXO_0000812	biolink:NamedThing	hepatitis B assessement	Screening for hepatitis B antibodies to determine if a patient has immunity to hepatitis B.		hp.json	hepatitis B testing|hep B antibody titer testing|hep B testing	http://purl.obolibrary.org/obo/MAXO_0000812		
UBERON:0035383	biolink:AnatomicalEntity	lateral wall of nasopharynx		NCIT:C12244|FMA:54908	hp.json	lateral nasopharynx	http://purl.obolibrary.org/obo/UBERON_0035383		
GO:0036135	biolink:BiologicalProcess	Schwann cell migration	The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function.		hp.json		http://purl.obolibrary.org/obo/GO_0036135		
OBO:MAXO_0000848	biolink:NamedThing	bilirubin measurement	The measurement of bilirubin present in a particular sample.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000848		
OBO:MAXO_0000849	biolink:NamedThing	indirect bilirubin measurement	A measurement of the unconjugated or non-water-soluble bilirubin in a biological specimen.	NCIT:C64483	hp.json		http://purl.obolibrary.org/obo/MAXO_0000849		
PR:000001444	biolink:Protein	cadherin-5	A cadherin that is a translation product of the human CDH5 gene or a 1:1 ortholog thereof.		hp.json	vascular endothelial cadherin|7B4 antigen|VE-cadherin|CD144|CDH5	http://purl.obolibrary.org/obo/PR_000001444		
OBO:MAXO_0000842	biolink:NamedThing	gamma glutamyl transpeptidase measurement	The determination of the amount of gamma-glutamyltranspeptidase present in the sample.	NCIT:C64847	hp.json	gamma-glutamyltranspeptidase test|gamma-glutamyltranspeptidase assessment|GTP test|gamma-GT test|GGT test	http://purl.obolibrary.org/obo/MAXO_0000842		
OBO:MAXO_0000843	biolink:NamedThing	albumin measurement	The determination of the amount of albumin (human) present in the sample.	NCIT:C64431	hp.json	ALB level test|albumin level measurement|albumin test|albumin assessment|albumin (human) test|albumin (human) assessment	http://purl.obolibrary.org/obo/MAXO_0000843		
OBO:MAXO_0000840	biolink:NamedThing	alanine transaminase test	The determination of the amount of alanine aminotransferase (human) present in the sample.	NCIT:C64433	hp.json	GPT test|serum glutamic-pyruvic transaminase test|alanine transaminase measurement|alanine aminotransferase (human) test|alanine aminotransferase (human) assessment|SGPT test|ALT test	http://purl.obolibrary.org/obo/MAXO_0000840		
OBO:MAXO_0000841	biolink:NamedThing	aspartate aminotransferase measurement	The determination of the amount of aspartate aminotransferase (human) present in the sample.	NCIT:C64467	hp.json	AST blood test|aspartate aminotransferase (human) assessment|aspartate aminotransferase (human) test|serum glutamic oxaloacetic transaminase test|aspartate aminotransferase blood test|SGOT test	http://purl.obolibrary.org/obo/MAXO_0000841		
OBO:MAXO_0000846	biolink:NamedThing	lactate dehydrogenase measurement	The determination of the amount of lactate dehydrogenase present in the sample.	NCIT:C64855	hp.json	LDH measurement	http://purl.obolibrary.org/obo/MAXO_0000846		
OBO:MAXO_0000847	biolink:NamedThing	5'-nucleotidase measurement	The determination of the amount of 5'-nucleotidase present in the sample.	NCIT:C79437	hp.json	5'-nucleotidase assessment|5'-nucleotidase test|5 prime nucleotidase measurement|5'- nucleotidase measurement	http://purl.obolibrary.org/obo/MAXO_0000847		
OBO:MAXO_0000844	biolink:NamedThing	alkaline phosphatase measurement	The determination of the amount of alkaline phosphatase present in the sample.	NCIT:C64432	hp.json	alk phos test|alkaline phosphatase assessment|ALP measurement|alkaline phosphatase test	http://purl.obolibrary.org/obo/MAXO_0000844		
OBO:MAXO_0000845	biolink:NamedThing	total bilirubin measurement	The measurement of the total amount of bilirubin present in a particular substrate. The substrate most often tested is blood, but other fluids extracted from the body may be used periodically depending on the purpose of the test.	NCIT:C38037	hp.json	total bilirubin level measurement|BILI measurement	http://purl.obolibrary.org/obo/MAXO_0000845		
CL:0011030	biolink:Cell	dermal microvascular endothelial cell	Any microvascular endothelial cell that is part of the dermis.		hp.json	dermal microvascular endothelium cell|DMEC cell	http://purl.obolibrary.org/obo/CL_0011030		
UBERON:0035398	biolink:AnatomicalEntity	branch of external carotid artery		NCIT:C32552|UMLS:C0447038|SCTID:244216003|FMA:70505	hp.json	subdivision of external carotid artery|external carotid arterial subdivision	http://purl.obolibrary.org/obo/UBERON_0035398		
PR:000013429	biolink:Protein	parathyroid hormone	A protein that is a translation product of the human PTH gene or a 1:1 ortholog thereof.		hp.json	parathyrin|parathormone|PTH	http://purl.obolibrary.org/obo/PR_000013429		
OBO:MAXO_0000839	biolink:NamedThing	thrombin time measurement	A measurement of the time it takes a plasma sample to clot after adding the active enzyme thrombin.	NCIT:C80365	hp.json	thrombin clotting time measurement|TT measurment|TCT measurement	http://purl.obolibrary.org/obo/MAXO_0000839		
OBO:MAXO_0000837	biolink:NamedThing	partial thromboplastin time test	A measurement of the length of time that it takes for clotting to occur when reagents are added to a plasma specimen. The test is partial due to the absence of tissue factor (Factor III) from the reaction mixture.	NCIT:C38462	hp.json	activated partial thromboplastin time test|APTT test|PTT test	http://purl.obolibrary.org/obo/MAXO_0000837		
OBO:MAXO_0000838	biolink:NamedThing	prothrombin time/international normalized ratio measurement	The determination of the ratio of the prothrombin time in a subject's specimen compared to a control sample. The measurement may be expressed as a ratio or percentage.	NCIT:C170591	hp.json	prothrombin time actual/control measurement|PTAC measurement|PT/INR measurement	http://purl.obolibrary.org/obo/MAXO_0000838		
OBO:MAXO_0000831	biolink:NamedThing	blood smear test	A procedure taking a thin layer of blood smeared on a glass microscope slide and stained to allow blood cells to be examined with a microscope.		hp.json	blood film test|peripheral blood film test|peripheral blood smear	http://purl.obolibrary.org/obo/MAXO_0000831		
OBO:MAXO_0000832	biolink:NamedThing	serum creatinine measurement	A quantitative measurement of the amount of creatinine present in a sample of serum.	NCIT:C61023	hp.json		http://purl.obolibrary.org/obo/MAXO_0000832		
OBO:MAXO_0000830	biolink:NamedThing	erythrocyte cell morphology measurement	An examination or assessment of the form and structure of red blood cells.	NCIT:C92296	hp.json	RBC morphology measurement|red blood cell morphology measurement	http://purl.obolibrary.org/obo/MAXO_0000830		
OBO:MAXO_0000835	biolink:NamedThing	T3 thyroid hormone test	Determination of triiodothyronine (T3) levels in blood as an indicator of thyroid health.		hp.json	triiodothyronine level test|T3 level test	http://purl.obolibrary.org/obo/MAXO_0000835		
OBO:MAXO_0000836	biolink:NamedThing	blood coagulation test	A measure of a patient's ability to clot, and how long it takes to clot.	NCIT:C62662	hp.json	coagulation study	http://purl.obolibrary.org/obo/MAXO_0000836		
OBO:MAXO_0000833	biolink:NamedThing	thyroid-stimulating hormone test	The determination of the amount of thyroid stimulating hormone present in blood.		hp.json	TSH level test|blood thyroid stimulating hormone test|thyroid stimulating hormone blood assessment	http://purl.obolibrary.org/obo/MAXO_0000833		
OBO:MAXO_0000834	biolink:NamedThing	T4 thyroid hormone test	Determination of thyroxine (T4) levels in the blood as an indicator of thyroid health.		hp.json	thyroxine level test|T4 level test	http://purl.obolibrary.org/obo/MAXO_0000834		
HP:0011650	biolink:PhenotypicFeature	Bilateral ductus arteriosus	The presence of both a left and a right ductus arteriosus.	UMLS:C0431501|SNOMEDCT_US:461093009	hp.json	Bilateral ductus botalli	http://purl.obolibrary.org/obo/HP_0011650		
HP:0011651	biolink:PhenotypicFeature	Double outlet right ventricle with doubly committed ventricular septal defect and pulmonary stenosis	A double outlet right ventricle with a subaortic ventritricular septal defect (a hole between the two bottom chambers (ventricles) of the heart), that extends anterosuperiorly and are closely related to the pulmonary artery as well, are considered to be doubly committed. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.	UMLS:C3165091|SNOMEDCT_US:448516008	hp.json	DORV with doubly committed VSD and pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0011651		
NCBITaxon:4932	biolink:OrganismalEntity	Saccharomyces cerevisiae		GC_ID:1	hp.json	baker's yeast|Mycoderma cerevisiae|Candida robusta|S. cerevisiae|Saccharomyces oviformis|Saccharomyces capensis|Saccharomyces uvarum var. melibiosus|Saccharomyces italicus|brewer's yeast	http://purl.obolibrary.org/obo/NCBITaxon_4932		
HP:0011652	biolink:PhenotypicFeature	Double outlet right ventricle with doubly committed ventricular septal defect without pulmonary stenosis	A double outlet right ventricle with a subaortic ventritricular septal defect (a hole between the two bottom chambers (ventricles) of the heart), that extends anterosuperiorly and are closely related to the pulmonary artery as well, are considered to be doubly committed. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.	UMLS:C4023247|Fyler:0604|Fyler:604	hp.json	DORV with doubly committed VSD|Double outlet right ventricle, doubly committed ventricular septal defect	http://purl.obolibrary.org/obo/HP_0011652		
CHEBI:28842	biolink:ChemicalSubstance	octadecanoic acid	A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and  plastics.	CAS:57-11-4|PMID:7763343|PMID:11425337|LIPID_MAPS_instance:LMFA01010018|PMID:19468063|Beilstein:608585|KNApSAcK:C00001238|Reaxys:608585|PMID:22735334|KEGG:D00119|PMID:19838949|HMDB:HMDB0000827|PMID:26884207|Gmelin:11738|PMID:18982377|Drug_Central:4611|PMID:16448636|CAS:57-11-4|Wikipedia:Stearic_acid|MetaCyc:STEARIC_ACID|KEGG:C01530|PDBeChem:STE|DrugBank:DB03193|PMID:17439666	hp.json	octadecoic acid|acide stearique|C18:0|Octadecansaeure|octadecanoic acid|CH3-[CH2]16-COOH|acide octadecanoique|STEARIC ACID|Stearinsaeure|Oktadekansaeure|stearic acid|Octadecanoic acid|18:0|n-octadecanoic acid	http://purl.obolibrary.org/obo/CHEBI_28842		3_STAR
HP:0011653	biolink:PhenotypicFeature	Double outlet right ventricle with non-committed ventricular septal defect and pulmonary stenosis	A double outlet right ventricle with a non-committed ventricular septal defect (VSD), which is a VSD that is anatomically related to, or close to, neither great vessel, being separated from both by considerable muscle, and also has a pulmonary stenosis; abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.	UMLS:C4023246	hp.json	DORV with non-committed VSD and pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0011653		
NCBITaxon:4930	biolink:OrganismalEntity	Saccharomyces		GC_ID:1	hp.json	Pachytichospora	http://purl.obolibrary.org/obo/NCBITaxon_4930		
HP:0011654	biolink:PhenotypicFeature	Double outlet right ventricle with non-committed ventricular septal defect without pulmonary stenosis	A double outlet right ventricle with a non-committed ventricular septal defect (VSD), which is a VSD that is anatomically related to, or close to, neither great vessel, being separated from both by considerable muscle, but there is not accompanying pulmonary stenosis; the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.	Fyler:603|UMLS:C4023245|Fyler:0603	hp.json	DORV with non-committed VSD without pulmonary stenosis|Double outlet right ventricle, noncommitted ventricular septal defect	http://purl.obolibrary.org/obo/HP_0011654		
HP:0011655	biolink:PhenotypicFeature	Double outlet right ventricle with subaortic ventricular septal defect and pulmonary stenosis	A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the aortic origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.	UMLS:C4023244	hp.json	DORV with subaortic VSD and pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0011655		
HP:0011656	biolink:PhenotypicFeature	Double outlet right ventricle with subaortic ventricular septal defect without pulmonary stenosis	A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the aortic origin. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.	UMLS:C4023243	hp.json	DORV with subaortic VSD without pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0011656		
HP:0011657	biolink:PhenotypicFeature	Double outlet right ventricle with subpulmonary ventricular septal defect and pulmonary stenosis	A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the pulmonary origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.	UMLS:C4023242	hp.json	DORV with subpulmonary VSD and pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0011657		
HP:0011658	biolink:PhenotypicFeature	Double outlet right ventricle with subpulmonary ventricular septal defect without pulmonary stenosis	A double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the pulmonary origin. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.	UMLS:C4023241	hp.json	DORV with subpulmonary VSD without pulmonary stenosis|Taussig-Bing anomaly	http://purl.obolibrary.org/obo/HP_0011658		
HP:0011659	biolink:PhenotypicFeature	Tetralogy of Fallot with absent pulmonary valve	Features of tetralogy of Fallot with either rudimentary ridges or the complete absence of pulmonic valve tissue.	UMLS:C1302264|SNOMEDCT_US:399228007	hp.json	Tetralogy of Fallot with absent pulmonary valve syndrome	http://purl.obolibrary.org/obo/HP_0011659		
OBO:MAXO_0000900	biolink:NamedThing	electrocardiography	A procedure that displays the electrical activity of the heart.	NCIT:C38053	hp.json	EKG|ECG	http://purl.obolibrary.org/obo/MAXO_0000900		
HP:0011640	biolink:PhenotypicFeature	Single coronary artery origin	The presence of a single coronary artery ostium from which both coronary arteries arise.	UMLS:C4023251	hp.json		http://purl.obolibrary.org/obo/HP_0011640		
HP:0011641	biolink:PhenotypicFeature	Coronary artery fistula	A congenital malformation with abnormal connection between one of the coronary arteries and a heart chamber or another blood vessel.	SNOMEDCT_US:373093003|Fyler:2230|UMLS:C0265898	hp.json	Coronary fistula	http://purl.obolibrary.org/obo/HP_0011641		
HP:0011642	biolink:PhenotypicFeature	Abnormal coronary sinus morphology	An abnormality of the coronary sinus, which is formed by the union of the great cardiac vein and the left marginal vein and terminates in the right atrium. The coronary sinus functions to o collect deoxygenated blood from the myocardium of the heart and drain it into the right atrium.	Fyler:2840|SNOMEDCT_US:253323000|UMLS:C0344680	hp.json	Abnormality of the coronary sinus	http://purl.obolibrary.org/obo/HP_0011642		
HP:0011643	biolink:PhenotypicFeature	Coronary sinus atrial septal defect	An atrial septal defect characterized by a deficiency in the tissue separating the coronary sinus from the left atrium (LA). This results in partial or complete unroofing of the coronary sinus leading to a predominantly left-to-right shunt through the coronary sinus (LA to coronary sinus to right atrium [RA]). The orifice of the ostium is frequently large because of the increased flow. From the RA side, the defect is located at the level of the coronary sinus ostium and may also include some deficiency in atrial tissue around the ostium. From the LA side, the size can be variable depending on the degree of unroofing of the coronary sinus.	UMLS:C2063331|ICD-10:Q21.1	hp.json		http://purl.obolibrary.org/obo/HP_0011643		
HP:0011644	biolink:PhenotypicFeature	Coronary sinus diverticulum	A venous pouch within the left ventricular wall, with a neck opening into the coronary sinus.	SNOMEDCT_US:447661004|UMLS:C3163894	hp.json	Diverticulum of the coronary sinus	http://purl.obolibrary.org/obo/HP_0011644		
HP:0008008	biolink:PhenotypicFeature	obsolete Progressive central visual loss			hp.json		http://purl.obolibrary.org/obo/HP_0008008		
HP:0008007	biolink:PhenotypicFeature	Primary congenital glaucoma		SNOMEDCT_US:415176004|UMLS:C1533041	hp.json		http://purl.obolibrary.org/obo/HP_0008007		
HP:0008009	biolink:PhenotypicFeature	Three rows of eyelashes		UMLS:C1860785	hp.json	Triple row of eyelashes|Three rows of eyelashes	http://purl.obolibrary.org/obo/HP_0008009		
HP:0011645	biolink:PhenotypicFeature	Dilatation of the sinus of Valsalva	Abnormal outpouching or sac-like dilatation of one of the anatomic dilations of the ascending aorta, which occurs just above the aortic valve.	UMLS:C2239253|Fyler:2316|SNOMEDCT_US:54160000	hp.json	Aneurysm of the aortic sinus|Aortic sinus aneurysm|Sinus of Valsalva aneurysm	http://purl.obolibrary.org/obo/HP_0011645		
HP:0011646	biolink:PhenotypicFeature	Juxtaductal coarctation of the aorta	Narrowing or constriction of the aorta localized at the insertion of the ductus arteriosus, i.e., to the juxtaductal region of aortic arch.	UMLS:C4023250	hp.json		http://purl.obolibrary.org/obo/HP_0011646		
HP:0008003	biolink:PhenotypicFeature	Jerky ocular pursuit movements		UMLS:C1853558	hp.json	Jerky smooth pursuit	http://purl.obolibrary.org/obo/HP_0008003		
HP:0011647	biolink:PhenotypicFeature	Postductal coarctation of the aorta	Narrowing or constriction of the aorta localized distal to the ductus arteriosus, i.e., to the postductal region of aortic arch.	SNOMEDCT_US:72242008|UMLS:C0265879	hp.json	Postductal aortic coarctation	http://purl.obolibrary.org/obo/HP_0011647		
HP:0008005	biolink:PhenotypicFeature	obsolete Congenital corneal dystrophy			hp.json		http://purl.obolibrary.org/obo/HP_0008005		
HP:0011648	biolink:PhenotypicFeature	Patent ductus arteriosus after birth at term	Abnormal persistent patency of the ductus arteriosus in postnatal life when birth was at 37 completed weeks of gestation or greater.	UMLS:C4023249	hp.json		http://purl.obolibrary.org/obo/HP_0011648		
HP:0008000	biolink:PhenotypicFeature	Decreased corneal reflex	An abnormally reduced response to stimulation of the cornea (by touch, foreign body, blowing air). The corneal reflex (also known as the blink reflex, normally results in an involuntary blinking of the eyelids.	UMLS:C0151572|MSH:D012021|SNOMEDCT_US:103254005	hp.json	Decreased blink reflex|Reduced corneal reflex	http://purl.obolibrary.org/obo/HP_0008000		
HP:0011649	biolink:PhenotypicFeature	Patent ductus arteriosus after premature birth	Abnormal persistent patency of the ductus arteriosus when birth was at less than 37 weeks completed gestation.	UMLS:C4023248	hp.json		http://purl.obolibrary.org/obo/HP_0011649		
HP:0008002	biolink:PhenotypicFeature	Abnormality of macular pigmentation	Abnormality of macular or foveal pigmentation.	UMLS:C1837087|UMLS:C4024756	hp.json	Macular pigmentary changes	http://purl.obolibrary.org/obo/HP_0008002		hposlim_core
HP:0008001	biolink:PhenotypicFeature	Foveal hyperpigmentation	Increased amount of pigmentation in the fovea centralis.	UMLS:C3809301	hp.json		http://purl.obolibrary.org/obo/HP_0008001		
HP:0011630	biolink:PhenotypicFeature	Complete diaphragmatic absence of pericardium	No pericardium over the diaphragmatic surface of the heart. It is a congenital defect, not the result of a pericardectomy. Pericardium is present on other parts of the heart.	UMLS:C4023259	hp.json		http://purl.obolibrary.org/obo/HP_0011630		
HP:0011631	biolink:PhenotypicFeature	Complete right sided absence of pericardium	No pericardium is present on the righthand side of the heart. It is a congenital absence of pericardium rather than the result of a pericardectomy.	UMLS:C4023258	hp.json		http://purl.obolibrary.org/obo/HP_0011631		
HP:0011632	biolink:PhenotypicFeature	Partial right sided absence of pericardium	A congenital anomaly with lack of part of the pericardium on the righthand side of the heart.	UMLS:C4023257	hp.json		http://purl.obolibrary.org/obo/HP_0011632		
HP:0011633	biolink:PhenotypicFeature	Complete left sided absence of pericardium	A congenital anomaly with complete lack of the pericardium on the lefthand side of the heart.	UMLS:C4023256	hp.json	Absent lining around of left side of heart	http://purl.obolibrary.org/obo/HP_0011633		
OBO:MAXO_0000927	biolink:NamedThing	newborn heart rate measurement	Determination of the newborn's heart rate.	NCIT:C87103	hp.json		http://purl.obolibrary.org/obo/MAXO_0000927		
OBO:MAXO_0000925	biolink:NamedThing	Apgar testing	A test conducted at 1 minute and 5 minutes after birth to determine the overall health of the newborn.	NCIT:C81230	hp.json		http://purl.obolibrary.org/obo/MAXO_0000925		
HP:0011634	biolink:PhenotypicFeature	Partial left sided absence of pericardium	A congenital anomaly with lack of part of the pericardium on the lefthand side of the heart.	UMLS:C4023255	hp.json		http://purl.obolibrary.org/obo/HP_0011634		
OBO:MAXO_0000920	biolink:NamedThing	physical therapist evaluation	An initial evaluation by a trained and certified individual who applies knowledge of the concepts, principles, and practices of physical therapy for the treatment or prevention of physical disability or disease.	NCIT:C53422	hp.json	physiotherapist evaluation	http://purl.obolibrary.org/obo/MAXO_0000920		
HP:0011635	biolink:PhenotypicFeature	Partial diaphragmatic absence of pericardium	Lack of a part of the pericardium over the diaphragmatic surface of the heart. It is a congenital defect, not the result of a pericardectomy. Pericardium is present on other parts of the heart.	UMLS:C4023254	hp.json		http://purl.obolibrary.org/obo/HP_0011635		
HP:0011636	biolink:PhenotypicFeature	Abnormal coronary artery origin	Isolated abnormalities of the coronary artery origins. This may be in associated with other structural heart malformations but not the patterns of complex structural heart malformations which result in abnormal course of the coronary arteries.	UMLS:C4023253	hp.json		http://purl.obolibrary.org/obo/HP_0011636		
HP:0011637	biolink:PhenotypicFeature	Anomalous origin of coronary artery from the pulmonary artery	A coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta.	UMLS:C4023252	hp.json		http://purl.obolibrary.org/obo/HP_0011637		
HP:0011638	biolink:PhenotypicFeature	Anomalous origin of left coronary artery from the pulmonary artery	Left main coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta, above the left cusp of the aortic valve.	SNOMEDCT_US:450301003|Fyler:3101|UMLS:C3472166	hp.json	ALCAPA|Bland-Garland-White syndrome|Anomalous left coronary artery from the pulmonary artery	http://purl.obolibrary.org/obo/HP_0011638		
OBO:MAXO_0000923	biolink:NamedThing	newborn examination	A general assessment of the overall health of a newborn.	NCIT:C84749	hp.json		http://purl.obolibrary.org/obo/MAXO_0000923		
HP:0011639	biolink:PhenotypicFeature	Anomalous origin of right coronary artery from the pulmonary artery	Right coronary artery begins (branches off from) the pulmonary artery rather than as normal from the root of the aorta, above the right cusp of the aortic valve.	UMLS:C3472165|SNOMEDCT_US:450300002	hp.json		http://purl.obolibrary.org/obo/HP_0011639		
CHEBI:41808	biolink:ChemicalSubstance	decane	A straight-chain alkane with 10 carbon atoms.	CAS:124-18-5|PMID:11762597|Wikipedia:Decane|LIPID_MAPS_instance:LMFA11000568|Beilstein:1696981|HMDB:HMDB0031450|Reaxys:1696981|Gmelin:67816|CAS:124-18-5|MetaCyc:CPD-9287|DrugBank:DB02826|PDBeChem:D10	hp.json	decane|n-Dekan|Dekan|DECANE|CH3-[CH2]8-CH3|n-decane	http://purl.obolibrary.org/obo/CHEBI_41808		3_STAR
OBO:MAXO_0000924	biolink:NamedThing	newborn behavior examination	The assessment of behavior in neonates.	NCIT:C81314	hp.json		http://purl.obolibrary.org/obo/MAXO_0000924		
OBO:MAXO_0000921	biolink:NamedThing	respiratory therapist evaluation	An initial assessment by a professional  trained and qualified to perform technical work concerned with administering therapeutic and diagnostic respiratory care and life support to patients with cardiopulmonary deficiencies and abnormalities.	NCIT:C53425	hp.json		http://purl.obolibrary.org/obo/MAXO_0000921		
OBO:MAXO_0000922	biolink:NamedThing	social worker evaluation	An initial assessment by a professionally trained person who is employed in the administration of charity, social service, and welfare. The assistance this professional provides helps disadvantaged individuals and families adjust themselves to the community.	NCIT:C28190	hp.json		http://purl.obolibrary.org/obo/MAXO_0000922		
CHEBI:28838	biolink:ChemicalSubstance	lutein			hp.json		http://purl.obolibrary.org/obo/CHEBI_28838		
HP:0011620	biolink:PhenotypicFeature	Abnormality of abdominal situs	An abnormality of the abdominal situs, i.e., of the sidedness of the abdomen and its organs.	UMLS:C4023266	hp.json		http://purl.obolibrary.org/obo/HP_0011620		
HP:0011621	biolink:PhenotypicFeature	Gerbode ventricular septal defect	A type of ventricular septal defect communicating directly between the left ventricle and right atrium. This is anatomically possible because the normal tricuspid valve is more apically displaced than the mitral valve.	SNOMEDCT_US:41893002|UMLS:C0265812|UMLS:C4023265	hp.json	Left ventricular - right atrial communication	http://purl.obolibrary.org/obo/HP_0011621		
HP:0011622	biolink:PhenotypicFeature	Inlet ventricular septal defect	A ventricular septal defect that involves the inlet of the right ventricular septum immediately inferior to the AV valve apparatus.	Fyler:1340	hp.json	Type 3 ventricular septal defect|Atrioventricular canal type ventricular septal defect	http://purl.obolibrary.org/obo/HP_0011622		
UBERON:0035471	biolink:AnatomicalEntity	posterior surface of kidney		NCIT:C32895|FMA:15590	hp.json	facies posterior renis|facies posterior (Ren)	http://purl.obolibrary.org/obo/UBERON_0035471		
OBO:MAXO_0000914	biolink:NamedThing	actigraphy	Use of a portable device (actigraph) to study sleep-wake patterns and circadian rhythms by assessing movement.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000914		
OBO:MAXO_0000915	biolink:NamedThing	polysomnography	A group of tests (usually central electroencephalogram (EEG) (C3 or C4), reference occipital EEG (O1 or O2), right and left electro-oculogram (EOG), mental or submental electromylogram (EMG), thoracic effort, abdominal effort, nasal and oral airflow, a microphone to record snoring, pulse oxygen saturation, EKG, and video recording to document body positions during sleep) taken during sleep.	NCIT:C114185	hp.json	PSG	http://purl.obolibrary.org/obo/MAXO_0000915		
CHEBI:16865	biolink:ChemicalSubstance	gamma-aminobutyric acid	A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	PMID:10630630|HMDB:HMDB0000112|LIPID_MAPS_instance:LMFA01100039|Gmelin:49775|KNApSAcK:C00001337|PMID:10930630|Beilstein:906818|PMID:16276116|DrugBank:DB02530|Reaxys:906818|MetaCyc:4-AMINO-BUTYRATE|KEGG:C00334|CAS:56-12-2|PMID:22770225|PMID:21614609|KEGG:D00058|PDBeChem:ABU|Wikipedia:Gamma-Aminobutyric_acid|CAS:56-12-2|BPDB:2298|Drug_Central:1262|CAS:56-12-2	hp.json	4-Aminobutyric acid|gamma-amino-n-butyric acid|4-Aminobutanoic acid|piperidinic acid|omega-aminobutyric acid|gamma-aminobutanoic acid|gamma-Aminobuttersaeure|GABA|4Abu|GAMMA-AMINO-BUTANOIC ACID|4-aminobutyric acid|4-aminobutanoic acid|4-aminobutanoic acid|gamma-aminobutyric acid|gamma-Aminobutyric acid|GABA|piperidic acid	http://purl.obolibrary.org/obo/CHEBI_16865		3_STAR
OBO:MAXO_0000919	biolink:NamedThing	dietician evaluation	An initial evaluation by a professional trained and qualified to provide nutritional services at individual, institutional and community levels in term of assessing nutritional needs.	NCIT:C28248	hp.json	nutritionist evaluation	http://purl.obolibrary.org/obo/MAXO_0000919		
HP:0011623	biolink:PhenotypicFeature	Muscular ventricular septal defect	The trabecular septum is the largest part of the interventricular septum. It extends from the membranous septum to the apex and superiorly to the infundibular septum. A defect in the trabecular septum is called muscular VSD if the defect is completely rimmed by muscle.	Fyler:1320|UMLS:C0685707|SNOMEDCT_US:94706008	hp.json	Ventricular septal defect, muscular|Type 4 ventricular septal defect	http://purl.obolibrary.org/obo/HP_0011623		
HP:0011624	biolink:PhenotypicFeature	Apical muscular ventricular septal defect	A muscular ventricular septal defect located at the apex of the heart.	UMLS:C4023264	hp.json		http://purl.obolibrary.org/obo/HP_0011624		
HP:0011625	biolink:PhenotypicFeature	Multiple muscular ventricular septal defects	A type of muscular ventricular septal defect characterized by the presence of multiple small defects in the ventricular septum.	UMLS:C4023263	hp.json	Swiss cheese ventricular septal defect	http://purl.obolibrary.org/obo/HP_0011625		
HP:0011626	biolink:PhenotypicFeature	Scimitar anomaly	Right pulmonary venous return to the inferior vena cava.	SNOMEDCT_US:111323005|UMLS:C0036400|ICD-10:Q26.8|SNOMEDCT_US:39905002|MSH:D012587	hp.json	Pulmonary venolobar syndrome|Scimitar syndrome	http://purl.obolibrary.org/obo/HP_0011626		
OBO:MAXO_0000912	biolink:NamedThing	assessment for sleep disturbance	A measurement or assessment to determine if a patient's sleep is disrupted.		hp.json	assessement for sleep disorders|sleep assessment|sleep disturbance screening	http://purl.obolibrary.org/obo/MAXO_0000912		
HP:0011627	biolink:PhenotypicFeature	Aorto-ventricular tunnel	Aorto-ventricular tunnel is a congenital, extracardiac channel which connects the ascending aorta above the sinutubular junction to the cavity of the left, or (less commonly) right ventricle.	UMLS:C4023262	hp.json		http://purl.obolibrary.org/obo/HP_0011627		
HP:0011628	biolink:PhenotypicFeature	Congenital defect of the pericardium	A developmental defect of the pericardium with congenital onset.	UMLS:C4023261	hp.json		http://purl.obolibrary.org/obo/HP_0011628		
OBO:MAXO_0000913	biolink:NamedThing	sleep assessment questionnaire	A questionnaire designed to determine sleep quality, daytime sleepiness, or other issues related to having restful sleep.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000913		
HP:0011629	biolink:PhenotypicFeature	Total absence of the pericardium	No pericardium around the heart, occurring as a congenital defect, not the result of a surgical pericardectomy.	Fyler:1910|SNOMEDCT_US:253732001|UMLS:C0345140	hp.json	Absent pericardium|Congenital absence of the pericardium	http://purl.obolibrary.org/obo/HP_0011629		
HP:0011692	biolink:PhenotypicFeature	Supraventricular tachycardia with a concealed accessory pathway on the right free wall		UMLS:C4023229	hp.json		http://purl.obolibrary.org/obo/HP_0011692		
HP:0011693	biolink:PhenotypicFeature	Supraventricular tachycardia with a concealed accessory pathway on the septum		UMLS:C4023228	hp.json		http://purl.obolibrary.org/obo/HP_0011693		
HP:0011694	biolink:PhenotypicFeature	Supraventricular tachycardia with a manifest accessory pathway		UMLS:C4023227	hp.json		http://purl.obolibrary.org/obo/HP_0011694		
HP:0011695	biolink:PhenotypicFeature	Cerebellar hemorrhage	Hemorrhage into the parenchyma of the cerebellum.	UMLS:C0149854|SNOMEDCT_US:75038005	hp.json	Cerebellar haemorrhage	http://purl.obolibrary.org/obo/HP_0011695		
HP:0008041	biolink:PhenotypicFeature	Late onset congenital glaucoma		UMLS:C1856441	hp.json		http://purl.obolibrary.org/obo/HP_0008041		
HP:0011696	biolink:PhenotypicFeature	Supraventricular tachycardia with a manifest accessory pathway on the left free wall		UMLS:C4023226	hp.json		http://purl.obolibrary.org/obo/HP_0011696		
HP:0011697	biolink:PhenotypicFeature	Supraventricular tachycardia with a manifest accessory pathway on the right free wall		UMLS:C4023225	hp.json		http://purl.obolibrary.org/obo/HP_0011697		
HP:0011698	biolink:PhenotypicFeature	Supraventricular tachycardia with a manifest accessory pathway on the septum		UMLS:C4023224	hp.json		http://purl.obolibrary.org/obo/HP_0011698		
HP:0011699	biolink:PhenotypicFeature	Atrial reentry tachycardia		UMLS:C4023223	hp.json		http://purl.obolibrary.org/obo/HP_0011699		
UBERON:0035401	biolink:AnatomicalEntity	posterior wall of nasopharynx		FMA:54907|NCIT:C12243	hp.json	posterior nasopharynx	http://purl.obolibrary.org/obo/UBERON_0035401		
HP:0011690	biolink:PhenotypicFeature	Permanent junctional reciprocating tachycardia	An incessant orthodromic tachycardia with anterograde conduction over the atrioventricular node and by retrograde conduction via an accessory pathway usually located in the posteroseptal region with slow and decremental conduction.	UMLS:C0340483|SNOMEDCT_US:233904005	hp.json		http://purl.obolibrary.org/obo/HP_0011690		
UBERON:0035403	biolink:AnatomicalEntity	hypophysial artery	An artery that supplies the pituitary gland.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035403		
HP:0011691	biolink:PhenotypicFeature	Supraventricular tachycardia with a concealed accessory pathway on the left free wall		UMLS:C4023230	hp.json		http://purl.obolibrary.org/obo/HP_0011691		
CHEBI:16813	biolink:ChemicalSubstance	galactitol	An optically inactive hexitol having meso-configuration.	PMID:22628202|PMID:17336832|KEGG:C01697|Beilstein:1721903|Reaxys:1721903|PMID:16664750|PMID:22654107|HMDB:HMDB0000107|PMID:16901854|CAS:608-66-2|KNApSAcK:C00001160|Wikipedia:Galactitol|PMID:21501963|Gmelin:83163|PMID:22155165|CAS:608-66-2|PMID:23830453|PMID:17979222|CAS:608-66-2|PMID:24643482	hp.json	D-Dulcitol|galactitol|(2R,3S,4R,5S)-hexane-1,2,3,4,5,6-hexol|L-galactitol|Melampyrit|Dulcitol|Galactitol|meso-galactitol|Euonymit|Melampyrin|D-galactitol|Dulcose	http://purl.obolibrary.org/obo/CHEBI_16813		3_STAR
CHEBI:16810	biolink:ChemicalSubstance	2-oxoglutarate(2-)	An oxo dicarboxylate obtained by deprotonation of both carboxy groups of 2-oxoglutaric acid.	CAS:64-15-3|PMID:11913971|KEGG:C00026|PMID:21196226|PMID:21184277|Beilstein:3664503|PMID:17190852|Reaxys:3664503|PMID:15612731|PMID:24828042|MetaCyc:2-KETOGLUTARATE|PMID:21791173|Gmelin:602479|PMID:19376872	hp.json	2-ketoglutarate|2-oxopentanedioate|alpha-ketoglutarate|2-oxopentanedioic acid, ion(2-)|2-oxoglutarate	http://purl.obolibrary.org/obo/CHEBI_16810		3_STAR
CHEBI:16811	biolink:ChemicalSubstance	methionine	A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	KEGG:C01733|PMID:22264337|UM-BBD_compID:c0094|CAS:59-51-8|PMID:2543976|KEGG:D04983|Gmelin:3117|CAS:59-51-8|CAS:59-51-8|PMID:16702333|Beilstein:636185|Reaxys:636185|Wikipedia:Methionine	hp.json	M|Met|DL-Methionine|2-Amino-4-(methylthio)butyric acid|2-amino-4-(methylsulfanyl)butanoic acid|2-amino-4-(methylthio)butanoic acid|methionine|Racemethionine|alpha-amino-gamma-methylmercaptobutyric acid|methionine|Hmet|Methionin|Methionine|metionina	http://purl.obolibrary.org/obo/CHEBI_16811		3_STAR
HP:0008037	biolink:PhenotypicFeature	Absent anterior chamber of the eye	Absence of the anterior chamber of the eye owing to a developmental defect.	SNOMEDCT_US:55457007|SNOMEDCT_US:404675003|UMLS:C0271004	hp.json		http://purl.obolibrary.org/obo/HP_0008037		
PR:P27352	biolink:Protein	cobalamin binding intrinsic factor (human)	A cobalamin binding intrinsic factor that is encoded in the genome of human.	UniProtKB:P27352	hp.json	CBLIF|INF (human)|IFMH|IF (human)|GIF|intrinsic factor (human)|gastric intrinsic factor (human)|hCBLIF	http://purl.obolibrary.org/obo/PR_P27352		
HP:0008036	biolink:PhenotypicFeature	obsolete Rod-cone dystrophy			hp.json		http://purl.obolibrary.org/obo/HP_0008036		
HP:0008039	biolink:PhenotypicFeature	Subepithelial corneal opacities		UMLS:C1857307	hp.json		http://purl.obolibrary.org/obo/HP_0008039		
HP:0008038	biolink:PhenotypicFeature	Aplastic/hypoplastic lacrimal glands	Absence or underdevelopment of the lacrimal gland.	UMLS:C1835602	hp.json	Absent/underdeveloped tear glands|Absent/underdeveloped lacrimal glands	http://purl.obolibrary.org/obo/HP_0008038		
HP:0008033	biolink:PhenotypicFeature	obsolete Congenital exotropia			hp.json		http://purl.obolibrary.org/obo/HP_0008033		
HP:0008035	biolink:PhenotypicFeature	Retinitis pigmentosa inversa	Retinitis pigmentosa inversa is form of retinal degeneration characterized by areas of retinal/chorioretinal degeneration with pigment migration in the macular area (in contrast to retinitis pigmentosa which, at early disease stages, predominantly affects the retinal periphery).	UMLS:C4021559	hp.json	Central retinitis pigmentosa	http://purl.obolibrary.org/obo/HP_0008035		
HP:0008034	biolink:PhenotypicFeature	Abnormal iris pigmentation	Abnormal pigmentation of the iris.	UMLS:C1834387	hp.json		http://purl.obolibrary.org/obo/HP_0008034		hposlim_core
HP:0011681	biolink:PhenotypicFeature	Subarterial ventricular septal defect	A ventricular septal defect that lies beneath the semilunar valve(s) in the conal or outlet septum.	UMLS:C3165130|Fyler:1330|SNOMEDCT_US:448876006	hp.json	Doubly committed ventricular septal defect|Conal ventricular septal defect|Type 1 ventricular septal defect|Infundibular ventricular septal defect|Supracristal ventricular septal defect	http://purl.obolibrary.org/obo/HP_0011681		
HP:0008051	biolink:PhenotypicFeature	obsolete Abnormality of the retinal pigment epithelium			hp.json		http://purl.obolibrary.org/obo/HP_0008051		
HP:0011682	biolink:PhenotypicFeature	Perimembranous ventricular septal defect	A ventricular septal defect that is confluent with and involves the membranous septum and is bordered by an atrioventricular valve, not including the type 3 VSDs.	SNOMEDCT_US:109428005|Fyler:1310|UMLS:C0344925	hp.json	Conoventricular ventricular septal defect|Type 2 ventricular septal defect|Membranous ventricular septal defect|Paramembranous ventricular septal defect|Perimembraneous ventricular septal defect|Ventricular septal defect, perimembranous	http://purl.obolibrary.org/obo/HP_0011682		
HP:0008050	biolink:PhenotypicFeature	Abnormality of the palpebral fissures	An anomaly of the space between the medial and lateral canthi of the two open eyelids.	UMLS:C4024750	hp.json	Abnormality of the opening between the eyelids|Abnormality of the palpebral fissures|Malformation of the palpebral fissures|Deformity of the palpebral fissures	http://purl.obolibrary.org/obo/HP_0008050		
HP:0008053	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the iris	Absence or underdevelopment of the iris.	UMLS:C4024748	hp.json	Absent/underdeveloped iris|Absent/small iris	http://purl.obolibrary.org/obo/HP_0008053		
HP:0011683	biolink:PhenotypicFeature	Restrictive ventricular septal defect	Any ventricular septal defect (VSD) that is small enough to restrict flow across it such that a pressure gradient exists between the two sides of the VSD.	UMLS:C0344924|SNOMEDCT_US:253551005	hp.json		http://purl.obolibrary.org/obo/HP_0011683		
CHEBI:28815	biolink:ChemicalSubstance	heparan sulfate	A linear polysaccharide in which the backbone consists of a variably sulfated repeating disaccharide unit.	KEGG:D08536|PMID:8713797|KEGG:C00925|Beilstein:8186767|CAS:9050-30-0|CAS:9050-30-0	hp.json	Heparan N-sulfate|Heparitin monosulfate|N-Acetylheparan sulfate|Heparin sulfate|Heparan sulphate|Heparan sulfate|Heparin monosulfate|Heparitin sulfate|Heparatan sulfate	http://purl.obolibrary.org/obo/CHEBI_28815		3_STAR
HP:0008052	biolink:PhenotypicFeature	Retinal fold	A wrinkle of retinal tissue projecting outward from the surface of the retina and visible as a line on fundoscopy.	UMLS:C0229197|SNOMEDCT_US:37480005	hp.json	Retinal folds	http://purl.obolibrary.org/obo/HP_0008052		
HP:0011684	biolink:PhenotypicFeature	Non-restrictive ventricular septal defect	Any ventricular septal defect (VSD) that does not restrict flow across it sufficiently to generate a pressure gradient between the two sides of the VSD.	SNOMEDCT_US:373131000|UMLS:C1298817	hp.json		http://purl.obolibrary.org/obo/HP_0011684		
HP:0011685	biolink:PhenotypicFeature	Infra-aortic superior vena cava	The superior vena cava passes below the aortic arch.	UMLS:C4023232	hp.json		http://purl.obolibrary.org/obo/HP_0011685		
HP:0011686	biolink:PhenotypicFeature	Abnormal coronary artery course	An abnormal path of a coronary artery.	SNOMEDCT_US:253714001|UMLS:C0345122	hp.json	Anomalous coronary artery course	http://purl.obolibrary.org/obo/HP_0011686		
HP:0011687	biolink:PhenotypicFeature	AV nodal tachycardia	A type of supraventricular tachycardia that originates in the atrioventricular node.	UMLS:C0857265	hp.json	AV nodal tachycardia|Atrioventricular nodal tachycardia	http://purl.obolibrary.org/obo/HP_0011687		
HP:0011688	biolink:PhenotypicFeature	Supraventricular tachycardia with an accessory connection mediated pathway	Supraventricular tachycardia in which an accessory pathway connecting the atria and ventricles, apart from the AV node, participates as a necessary part of a reentrant mechanism.	UMLS:C4021132	hp.json	Atrioventricular re-entry tachycardia|Supraventricular tachycardia with an accessory connexion mediated pathway	http://purl.obolibrary.org/obo/HP_0011688		
HP:0011680	biolink:PhenotypicFeature	Single ventricle of indeterminate morphology		UMLS:C4023233	hp.json		http://purl.obolibrary.org/obo/HP_0011680		
HP:0008048	biolink:PhenotypicFeature	Abnormal line of Schwalbe morphology	An abnormality of the line of Schwalbe.	UMLS:C4021856	hp.json	Abnormality of the line of Schwalbe	http://purl.obolibrary.org/obo/HP_0008048		
HP:0011689	biolink:PhenotypicFeature	Supraventricular tachycardia with a concealed accessory connection	Supraventricular tachycardia with an accessory connection mediated pathway that is called concealed becasue it is not seen on the ECG during sinus rhythm.	UMLS:C4023231	hp.json	Supraventricular tachycardia with a concealed accessory connexion	http://purl.obolibrary.org/obo/HP_0011689		
HP:0008047	biolink:PhenotypicFeature	Abnormality of the vasculature of the eye		UMLS:C4024752	hp.json	Abnormality of eye blood vessels	http://purl.obolibrary.org/obo/HP_0008047		
HP:0008049	biolink:PhenotypicFeature	Abnormality of the extraocular muscles	An abnormality of an extraocular muscle.	UMLS:C4024751	hp.json		http://purl.obolibrary.org/obo/HP_0008049		
HP:0008043	biolink:PhenotypicFeature	Retinal arteriolar constriction	Decreased retinal arteriolar diameters, which may decrease blood flow and slow oxygen delivery to regions of the retina.	UMLS:C2176208	hp.json	Retinal arteriolar narrowing|Constricted retinal arterioles|Narrow retinal arterioles	http://purl.obolibrary.org/obo/HP_0008043		
HP:0008046	biolink:PhenotypicFeature	Abnormal retinal vascular morphology	A structural abnormality of retinal vasculature.	UMLS:C4024753	hp.json	Abnormality of the retinal vasculature|Abnormality of retina blood vessels	http://purl.obolibrary.org/obo/HP_0008046		
HP:0008045	biolink:PhenotypicFeature	Enlarged flash visual evoked potentials		UMLS:C4021558	hp.json	High flash visual evoked potentials	http://purl.obolibrary.org/obo/HP_0008045		
HP:0011670	biolink:PhenotypicFeature	Left superior vena cava draining to coronary sinus	A persistent left superior vena cava (PLSVC) that drains into the right atrium via the coronary sinus. This is the case in 80-92% of cases of PLSVC and results in no hemodynamic consequence.	ICD-10:Q26.1|UMLS:C2677768	hp.json		http://purl.obolibrary.org/obo/HP_0011670		
HP:0011671	biolink:PhenotypicFeature	Interrupted inferior vena cava with azygous continuation	Interrupted inferior vena cava with azygous continuation is the result of connection failure between the right subcardinal vein and the right vitelline vein. Consequently, venous blood from the caudal part of the body reaches the heart via the azygous vein and superior vena cava.	UMLS:C4023237|ICD-10:26.8	hp.json		http://purl.obolibrary.org/obo/HP_0011671		
HP:0008020	biolink:PhenotypicFeature	Cone dystrophy	Inherited progressive cone degeneration.	UMLS:C3665342|UMLS:C0730290	hp.json	Progressive cone dystrophy|Progressive cone degeneration	http://purl.obolibrary.org/obo/HP_0008020		
HP:0011672	biolink:PhenotypicFeature	Cardiac myxoma	A myxoma (tumor of primitive connective tissue) of the heart. Cardiac myxomas consist of stellate to plump, cytologically bland mesenchymal cells set in a myxoid stroma. Cardiac myxomas are of endocardial origin and general project from the endocardium into a cardiac chamber.	SNOMEDCT_US:426191007|UMLS:C1960546|NCIT:C6577	hp.json		http://purl.obolibrary.org/obo/HP_0011672		
HP:0011673	biolink:PhenotypicFeature	Cardiac hemangioma	Abnormal proliferation of blood vessels within the cardiac cavities attached to the endocardium.	UMLS:C1707298|NCIT:C3085	hp.json		http://purl.obolibrary.org/obo/HP_0011673		
HP:0011674	biolink:PhenotypicFeature	Cardiac teratoma	A teratoma within the heart. Most commonly, these tumors are detected in the pericardial cavity attached to the pulmonary artery and aorta. The tumour size within the heart varies from 2 to 9 cm in diameter, and intrapericardial tumors as large as 15 cm have been reported. Intracardiac tumors arise from the atrial or ventricular wall as nodular masses protruding into the cardiac chambers. Cardiac and pericardial teratomas are easily detected in the fetus and neonate by two-dimensional echocardiography as heterogeneous and encapsulated cystic masses. Histologically, cardiac teratomas contain multiple immature elements including epithelium, neuroglial tissue, thyroid, pancreas, smooth and skeletal muscle, cartilage and bone.	NCIT:C3403|UMLS:C1112387	hp.json		http://purl.obolibrary.org/obo/HP_0011674		
HP:0011675	biolink:PhenotypicFeature	Arrhythmia	Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both.	SNOMEDCT_US:698247007|SNOMEDCT_US:102594003|UMLS:C0264886|UMLS:C0003811|MSH:D001145|UMLS:C1832603|UMLS:C0855329|UMLS:C1842820|SNOMEDCT_US:44808001|MSH:C562490|UMLS:C0522055	hp.json	Irregular heart beat|Cardiac arrhythmia|Arrhythmias|Cardiac arrhythmias|Cardiac rhythm disturbances|Heart rhythm disorders|Abnormal heart rate|Irregular heartbeat	http://purl.obolibrary.org/obo/HP_0011675		
HP:0011676	biolink:PhenotypicFeature	Tetralogy of Fallot with absent subarterial conus		UMLS:C4023236	hp.json		http://purl.obolibrary.org/obo/HP_0011676		
HP:0011677	biolink:PhenotypicFeature	Tetralogy of Fallot with atrioventricular canal defect		UMLS:C4023235	hp.json		http://purl.obolibrary.org/obo/HP_0011677		
HP:0008019	biolink:PhenotypicFeature	Superior lens subluxation	Partial dislocation of the lens in a superior direction.	UMLS:C2036843	hp.json	Superior subluxated lens	http://purl.obolibrary.org/obo/HP_0008019		
CHEBI:16831	biolink:ChemicalSubstance	3-hydroxy-3-methylglutaric acid	A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.	Drug_Central:1670|KEGG:D04897|PMID:9658458|PDBeChem:MAH|PMID:10916782|KEGG:C03761|Reaxys:1769194|Beilstein:1769194|HMDB:HMDB0000355|PMID:3063529|PMID:6083597|PMID:4717513|DrugBank:DB04377|CAS:503-49-1|CAS:503-49-1|PMID:17941049|KNApSAcK:C00001187|MetaCyc:CPD-547	hp.json	meglutolum|3-hydroxy-3-methylpentanedioic acid|(S)-3-Hydroxy-3-methylglutaric acid|Dicrotalic acid|3-HYDROXY-3-METHYL-GLUTARIC ACID|beta-Hydroxy-beta-methylglutaric acid|meglutol|meglutol|(S)-Meglutol|3-Hydroxy-3-methylpentanedioic acid|beta-hydroxy-beta-methylglutaric acid	http://purl.obolibrary.org/obo/CHEBI_16831		3_STAR
HP:0011678	biolink:PhenotypicFeature	Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collateral arteries	A type of tetralogy of Fallot with pulmonary atresia in which all pulmonary blood flow is derived from major aortopulmonary collateral arteries (MAPCA).	UMLS:C4023234	hp.json		http://purl.obolibrary.org/obo/HP_0011678		
HP:0011679	biolink:PhenotypicFeature	Tetralogy of Fallot with pulmonary stenosis	The commonest form of tetralogy of Fallot characterized by pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy, without pulmonary atresia, absent pulmonary valve, atrioventricular canal defect or absent subarterial conus.	SNOMEDCT_US:253512000|UMLS:C0344881	hp.json		http://purl.obolibrary.org/obo/HP_0011679		
HP:0008014	biolink:PhenotypicFeature	Central fundal arteriolar microaneurysms	Microscopic aneurysms of the retinal arterioles near the central part of the fundus, visible as small round dark red dots on the retinal surface (not arising from visible vessels) that are by definition less than the diameter of the major optic veins as they cross the optic disc.	UMLS:C4024755	hp.json		http://purl.obolibrary.org/obo/HP_0008014		
HP:0008017	biolink:PhenotypicFeature	obsolete Depigmented lesions of the retinal pigment epithelium			hp.json		http://purl.obolibrary.org/obo/HP_0008017		
HP:0008011	biolink:PhenotypicFeature	Peripheral opacification of the cornea	Reduced transparency of the peripheral region of the cornea.	UMLS:C0155100|SNOMEDCT_US:55713007	hp.json	Peripheral corneal opacity	http://purl.obolibrary.org/obo/HP_0008011		
HP:0008012	biolink:PhenotypicFeature	obsolete Congenital myopia			hp.json		http://purl.obolibrary.org/obo/HP_0008012		
HP:0011660	biolink:PhenotypicFeature	Anomalous origin of one pulmonary artery from ascending aorta	Anomalous origin of one pulmonary artery from the ascending aorta with the contralateral pulmonary artery arising from the right ventricle.	UMLS:C4021134|Fyler:550|Fyler:0550	hp.json	Hemitruncus	http://purl.obolibrary.org/obo/HP_0011660		
HP:0011661	biolink:PhenotypicFeature	Anomalous origin of left pulmonary artery from ascending aorta	The left pulmonary artery originates from the ascending aorta in the presence of a pulmonary valve and main pulmonary artery.	SNOMEDCT_US:253637002|UMLS:C0345040	hp.json		http://purl.obolibrary.org/obo/HP_0011661		
HP:0008031	biolink:PhenotypicFeature	Posterior Y-sutural cataract	A type of sutural cataract in which the opacity follows the posterior Y suture.	UMLS:C4021560	hp.json	Posterior Y-sutural cataracts	http://purl.obolibrary.org/obo/HP_0008031		
HP:0011662	biolink:PhenotypicFeature	Tricuspid atresia	Failure to develop of the tricuspid valve and thus lack of the normal connection between the right atrium and the right ventricle.	Fyler:400|ICD-10:Q22.4|SNOMEDCT_US:63042009|SNOMEDCT_US:253455004|UMLS:C0243002|MSH:D018785|Fyler:0400|EPCC:06.01.01	hp.json	Tricuspid valve atresia	http://purl.obolibrary.org/obo/HP_0011662		
HP:0008030	biolink:PhenotypicFeature	Retinal arteritis		UMLS:C0271069|SNOMEDCT_US:11255009	hp.json		http://purl.obolibrary.org/obo/HP_0008030		
HP:0011663	biolink:PhenotypicFeature	Right ventricular cardiomyopathy	Right ventricular dysfunction (global or regional) with functional and morphological right ventricular abnormalities, with or without left ventricular disease.	UMLS:C2063326	hp.json	Cardiomyopathy, right ventricular|Cardiomyopathy, esp. right ventricular	http://purl.obolibrary.org/obo/HP_0011663		
HP:0011664	biolink:PhenotypicFeature	Left ventricular noncompaction cardiomyopathy	Left ventricular non-compaction (LVNC) is characterized by prominent left ventricular trabeculae and deep inter-trabecular recesses. The myocardial wall is often thickened with a thin, compacted epicardial layer and a thickened endocardial layer. In some patients, LVNC is associated with left ventricular dilatation and systolic dysfunction, which can be transient in neonates.	UMLS:C4021133	hp.json	Left ventricular non-compaction cardiomyopathy	http://purl.obolibrary.org/obo/HP_0011664		
HP:0011665	biolink:PhenotypicFeature	Takotsubo cardiomyopathy	Transient left ventricular apical ballooning syndrome or takotsubo cardiomyopathy is characterized by transient regional systolic dysfunction involving the left ventricular apex and/or mid-ventricle in the absence of obstructive coronary disease on coronary angiography. Patients present with an abrupt onset of angina-like chest pain, and have diffuse T-wave inversion, sometimes preceded by ST-segment elevation, and mild cardiac enzyme elevation.	SNOMEDCT_US:441541008|UMLS:C1739395|MSH:D054549	hp.json	Broken-heart syndrome	http://purl.obolibrary.org/obo/HP_0011665		
HP:0011666	biolink:PhenotypicFeature	Absent right superior vena cava	Absence of the right superior vena cava (RSVC). An absent RSVC is always associated with a persistent left superior vena cava (PLSVC). During normal fetal development, the left-sided anterior venous cardinal system regresses, leaving the coronary sinus (CS) and the ligament of Marshall. Failure of the closure of the left anterior cardinal vein results in PLSVC. In general, PLSVC is associated with the right superior vena cava (RSVC) and drains into the RA via a dilated CS. When developmental arrest occurs at an earlier stage, the CS is absent and the PLSVC drains into the left atrium.	SNOMEDCT_US:253308005|UMLS:C0344656	hp.json		http://purl.obolibrary.org/obo/HP_0011666		
GO:0051904	biolink:BiologicalProcess	pigment granule transport	The directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	pigment granule translocation	http://purl.obolibrary.org/obo/GO_0051904		
GO:0051905	biolink:BiologicalProcess	establishment of pigment granule localization	The directed movement of a pigment granule to a specific location.		hp.json	establishment of pigment granule localisation	http://purl.obolibrary.org/obo/GO_0051905		
UBERON:0035431	biolink:AnatomicalEntity	mediastinal pleura	The parietal pleura that lines the mediastinum.	NCIT:C94820|FMA:9736	hp.json	pars mediastinalis (pleurae)|pars mediastinalis pleurae parietalis|mediastinal part of parietal pleura	http://purl.obolibrary.org/obo/UBERON_0035431		
CHEBI:16827	biolink:ChemicalSubstance	corticosterone	A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.	Wikipedia:Corticosterone|PMID:24446162|MetaCyc:CORTICOSTERONE|PDBeChem:C0R|PMID:16817814|PMID:11448093|HMDB:HMDB0001547|LIPID_MAPS_instance:LMST02030186|CAS:50-22-6|KEGG:C02140|Beilstein:2339601|PMID:10438974|CAS:50-22-6|LINCS:LSM-5814|CAS:50-22-6	hp.json	11beta,21-dihydroxyprogesterone|(11beta)-11,21-dihydroxypregn-4-ene-3,20-dione|Corticosterone|CORTICOSTERONE|Reichstein's substance H|Kendall's compound B|corticosterone|11beta,21-dihydroxypregn-4-ene-3,20-dione|17-deoxycortisol|11beta,21-Dihydroxy-4-pregnene-3,20-dione	http://purl.obolibrary.org/obo/CHEBI_16827		3_STAR
UBERON:0035435	biolink:AnatomicalEntity	right suprarenal vein	A vein that drains blood from the right adrenal gland into the inferior vena cava.	NCIT:C53131|FMA:14343	hp.json	vena suprarenalis (adrenalis) dextra	http://purl.obolibrary.org/obo/UBERON_0035435		human_reference_atlas
HP:0011667	biolink:PhenotypicFeature	Bilateral superior vena cava with bridging vein		UMLS:C4023240	hp.json		http://purl.obolibrary.org/obo/HP_0011667		
HP:0008026	biolink:PhenotypicFeature	Horizontal opticokinetic nystagmus		UMLS:C4024754	hp.json		http://purl.obolibrary.org/obo/HP_0008026		
HP:0011668	biolink:PhenotypicFeature	Bilateral superior vena cava with no bridging vein		UMLS:C4023239	hp.json		http://purl.obolibrary.org/obo/HP_0011668		
HP:0011669	biolink:PhenotypicFeature	Left superior vena cava draining directly to the left atrium	A persistent left superior vena cava (PLSVC) that drains into the left atrium instead of the right atrium via the coronary sinus, resulting in a right to left sided shunt.	UMLS:C4023238	hp.json		http://purl.obolibrary.org/obo/HP_0011669		
HP:0008028	biolink:PhenotypicFeature	Cystoid macular degeneration	A form of macular degeneration characterized by the presence of multiple cysts in the macula.	UMLS:C0154850|SNOMEDCT_US:14046000	hp.json	Cystic macular degeneration	http://purl.obolibrary.org/obo/HP_0008028		
HP:0008024	biolink:PhenotypicFeature	obsolete Congenital nuclear cataract			hp.json		http://purl.obolibrary.org/obo/HP_0008024		
GO:0000323	biolink:CellularComponent	lytic vacuole	A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.		hp.json		http://purl.obolibrary.org/obo/GO_0000323		
CHEBI:38260	biolink:ChemicalSubstance	pyrrolidines	Any of a class of heterocyclic amines having a saturated five-membered ring.		hp.json		http://purl.obolibrary.org/obo/CHEBI_38260		3_STAR
CHEBI:26271	biolink:ChemicalSubstance	proline	An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.	PMID:21903295|PMID:21400017|PMID:22280966|CAS:609-36-9|PMID:16534801|PMID:22264337|CAS:609-36-9|CAS:609-36-9|Gmelin:26927|PMID:22770225|Beilstein:80809|Reaxys:80809|Wikipedia:Proline|KEGG:C16435	hp.json	proline|Hpro|Prolin|proline|DL-Proline|pyrrolidine-2-carboxylic acid|prolina	http://purl.obolibrary.org/obo/CHEBI_26271		3_STAR
CHEBI:26273	biolink:ChemicalSubstance	proline derivative	An amino acid derivative resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of proline by a heteroatom. The definition normally excludes peptides containing proline residues.		hp.json	proline derivatives	http://purl.obolibrary.org/obo/CHEBI_26273		3_STAR
GO:0097212	biolink:BiologicalProcess	lysosomal membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.		hp.json	lysosome membrane organization|lysosomal membrane organisation	http://purl.obolibrary.org/obo/GO_0097212		
GO:1903489	biolink:NamedThing	positive regulation of lactation			hp.json		http://purl.obolibrary.org/obo/GO_1903489		
GO:1903488	biolink:NamedThing	negative regulation of lactation			hp.json		http://purl.obolibrary.org/obo/GO_1903488		
GO:1903487	biolink:NamedThing	regulation of lactation			hp.json		http://purl.obolibrary.org/obo/GO_1903487		
GO:0000313	biolink:CellularComponent	organellar ribosome	A ribosome contained within a subcellular membrane-bounded organelle.		hp.json		http://purl.obolibrary.org/obo/GO_0000313		
GO:0061298	biolink:BiologicalProcess	retina vasculature development in camera-type eye	The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.		hp.json	retinal vasculature development	http://purl.obolibrary.org/obo/GO_0061298		
GO:0061299	biolink:BiologicalProcess	retina vasculature morphogenesis in camera-type eye	The process in which the vasculature of the retina is generated and organized.		hp.json	retinal vasculature morphogenesis	http://purl.obolibrary.org/obo/GO_0061299		
GO:0097272	biolink:BiologicalProcess	ammonium homeostasis	Any biological process involved in the maintenance of an internal steady state of ammonium.		hp.json	ammonia homeostasis	http://purl.obolibrary.org/obo/GO_0097272		
HP:0011610	biolink:PhenotypicFeature	Type IV truncus arteriosus	Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) whereby the aortic arch is hypoplastic or interrupted, and a large patent ductus arteriosus is present.	Fyler:0540|UMLS:C4021135|Fyler:540	hp.json	Persistent truncus arteriosus type IV|Type 4 truncus arteriosus	http://purl.obolibrary.org/obo/HP_0011610		
GO:0097275	biolink:BiologicalProcess	cellular ammonium homeostasis	Any biological process involved in the maintenance of an internal steady state of ammonium at the level of the cell.		hp.json	cellular ammonia homeostasis	http://purl.obolibrary.org/obo/GO_0097275		
HP:0011611	biolink:PhenotypicFeature	Interrupted aortic arch	Non-continuity of the arch of aorta with an atretic point or absent segment.	SNOMEDCT_US:218728005|UMLS:C0152419|Fyler:1241|Fyler:1250	hp.json	Aortic arch obstruction|Atretic transverse aortic arch	http://purl.obolibrary.org/obo/HP_0011611		
CHEBI:41865	biolink:ChemicalSubstance	sebacic acid	An alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane.	PMID:22770225|LIPID_MAPS_instance:LMFA01170006|PDBeChem:DEC|MetaCyc:CPD-3623|CAS:111-20-6|Gmelin:102423|CAS:111-20-6|KEGG:C08277|CAS:111-20-6|PMID:9439441|HMDB:HMDB0000792|Beilstein:1210591|KNApSAcK:C00001202|DrugBank:DB07645|Reaxys:1210591|Wikipedia:Sebacic_acid	hp.json	1,10-decanedioic acid|SEBACIC ACID|Sebacinsaeure|Decanedioic acid|1,8-dicarboxyoctane|decanedioic acid|Sebacic acid	http://purl.obolibrary.org/obo/CHEBI_41865		3_STAR
HP:0011612	biolink:PhenotypicFeature	Interrupted aortic arch type A	Non-continuity of the aortic arch with an atretic point or absent segment at the level of the isthmus.	SNOMEDCT_US:253681005|UMLS:C0345092	hp.json		http://purl.obolibrary.org/obo/HP_0011612		
HP:0011613	biolink:PhenotypicFeature	Interrupted aortic arch type B	Non-continuity of the aortic arch with an atretic point or absent segment between the left carotid and subclavian arteries.	SNOMEDCT_US:253682003|Fyler:1252|UMLS:C0345093	hp.json	Interrupted aortic arch, type b	http://purl.obolibrary.org/obo/HP_0011613		
HP:0011614	biolink:PhenotypicFeature	Interrupted aortic arch type C	Non-continuity of the aortic arch with an atretic point or absent segment between the innominate and left carotid arteries.	SNOMEDCT_US:253683008|UMLS:C0345094	hp.json		http://purl.obolibrary.org/obo/HP_0011614		
HP:0011615	biolink:PhenotypicFeature	Abnormal pulmonary situs morphology	An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, which is defined by characteristics such as the number of lobes per lung and the relationship of the pulmonary arteries to their bronchi.	UMLS:C4023271	hp.json	Abnormality of pulmonary situs	http://purl.obolibrary.org/obo/HP_0011615		
HP:0011616	biolink:PhenotypicFeature	Pulmonary situs inversus	Mirror image arrangement of the mainstem bronchi with the right pulmonary artery posterior to the right upper lobe bronchus and the left pulmonary artery anterior to the left upper lobe bronchus.	UMLS:C4023270	hp.json		http://purl.obolibrary.org/obo/HP_0011616		
HP:0011617	biolink:PhenotypicFeature	Pulmonary situs ambiguus	An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which the morphology of both left and right lungs is the same.	UMLS:C4023269	hp.json		http://purl.obolibrary.org/obo/HP_0011617		
HP:0011618	biolink:PhenotypicFeature	Pulmonary situs ambiguus with bilateral morphologic right lungs	An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which both lungs have the morphology of a right lung.	UMLS:C4023268	hp.json		http://purl.obolibrary.org/obo/HP_0011618		
HP:0011619	biolink:PhenotypicFeature	Pulmonary situs ambiguus with bilateral morphologic left lungs	An abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, in which both lungs have the morphology of a left lung.	UMLS:C4023267	hp.json		http://purl.obolibrary.org/obo/HP_0011619		
GO:0097283	biolink:BiologicalProcess	keratinocyte apoptotic process	Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.		hp.json	keratinocyte apoptosis	http://purl.obolibrary.org/obo/GO_0097283		
HP:0011600	biolink:PhenotypicFeature	Abnormal direction of ventricular apex	Abnormal plane of direction of the heart from the base to the apex. Left sided is normal.	UMLS:C4023275	hp.json		http://purl.obolibrary.org/obo/HP_0011600		
CHEBI:28892	biolink:ChemicalSubstance	ganglioside	A molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids linked on the sugar chain.	PMID:2088646|KEGG:C01808|LIPID_MAPS_class:LMSP0601|PMID:16158191|Wikipedia:Ganglioside	hp.json	gangliosides|sialoglycosphingolipids|gangliosides|Ganglioside	http://purl.obolibrary.org/obo/CHEBI_28892		3_STAR
HP:0011609	biolink:PhenotypicFeature	Type III truncus arteriosus	Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) whereby one of the two pulmonary artery branched does not arise from the common pulmonary trunk, but instead from the ductus arteriosus or directly from the aorta.	UMLS:C4021136|Fyler:530|Fyler:0530	hp.json	Persistent truncus arteriosus type III|Type 3 truncus arteriosus	http://purl.obolibrary.org/obo/HP_0011609		
HP:0011601	biolink:PhenotypicFeature	Rightward direction of ventricular apex	Abnormal plane of direction of the heart from the base to the apex towards the right. Left sided is normal.	UMLS:C4023274	hp.json		http://purl.obolibrary.org/obo/HP_0011601		
HP:0011602	biolink:PhenotypicFeature	Midline direction of ventricular apex	Abnormal plane of direction of the heart from the base to the apex in the midline. Left sided is normal.	UMLS:C4023273	hp.json		http://purl.obolibrary.org/obo/HP_0011602		
HP:0011603	biolink:PhenotypicFeature	Congenital malformation of the great arteries	Defect or defects of the morphogenesis of the aorta and pulmonary arteries.	UMLS:C0478012	hp.json		http://purl.obolibrary.org/obo/HP_0011603		
HP:0011604	biolink:PhenotypicFeature	Aortopulmonary window	A congenital anomaly with an abnormal connection between the aorta and the main pulmonary artery resulting in an aortopulmonary shunt.	UMLS:C0003516|SNOMEDCT_US:17024001|Fyler:560|Fyler:0560|MSH:D001028	hp.json		http://purl.obolibrary.org/obo/HP_0011604		
HP:0011605	biolink:PhenotypicFeature	Congenitally corrected transposition of the great arteries with ventricular septal defect	A congenitally corrected transposition of the great arteries with a ventricular septal defect: a hole between the two bottom chambers (ventricles) of the heart. The ventricular septal defect is centered around the most superior aspect of the ventricular septum.	UMLS:C4023272	hp.json	ccTGA|CCTGA	http://purl.obolibrary.org/obo/HP_0011605		
HP:0011606	biolink:PhenotypicFeature	obsolete Transposition of the great arteries with intact ventricular septum			hp.json		http://purl.obolibrary.org/obo/HP_0011606		
HP:0011607	biolink:PhenotypicFeature	obsolete Transposition of the great arteries with ventricular septal defect			hp.json		http://purl.obolibrary.org/obo/HP_0011607		
HP:0011608	biolink:PhenotypicFeature	Type II truncus arteriosus	Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) with each pulmonary artery arising separate from each other on the posterior or lateral aspect of the truncus.	Fyler:520|Fyler:0520|UMLS:C4021137	hp.json	Persistent truncus arteriosus type II|Type 2 truncus arteriosus	http://purl.obolibrary.org/obo/HP_0011608		
CHEBI:28868	biolink:ChemicalSubstance	fatty acid anion	The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid.	PMID:18628202|KEGG:C02403	hp.json	Fatty acid anion|Fettsaeureanionen|a fatty acid|Alkanate|Fettsaeureanion|anion de l'acide gras|fatty acid anions|acidos grasos anionicos|acido graso anionico	http://purl.obolibrary.org/obo/CHEBI_28868		3_STAR
GO:0002920	biolink:BiologicalProcess	regulation of humoral immune response	Any process that modulates the frequency, rate, or extent of a humoral immune response.		hp.json		http://purl.obolibrary.org/obo/GO_0002920		
GO:0014909	biolink:BiologicalProcess	smooth muscle cell migration	The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0014909		
GO:0002921	biolink:BiologicalProcess	negative regulation of humoral immune response	Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.		hp.json	inhibition of humoral immune response|downregulation of humoral immune response|down-regulation of humoral immune response|down regulation of humoral immune response	http://purl.obolibrary.org/obo/GO_0002921		
GO:0097252	biolink:BiologicalProcess	oligodendrocyte apoptotic process	Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons.		hp.json	oligodendrocyte apoptosis	http://purl.obolibrary.org/obo/GO_0097252		
GO:0014904	biolink:BiologicalProcess	myotube cell development	The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.		hp.json		http://purl.obolibrary.org/obo/GO_0014904		
GO:0014902	biolink:BiologicalProcess	myotube differentiation	The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.		hp.json		http://purl.obolibrary.org/obo/GO_0014902		
PR:P17931	biolink:Protein	galectin-3 (human)	A galectin-3 that is encoded in the genome of human.	UniProtKB:P17931	hp.json	MAC2|hLGALS3|35 kDa lectin (human)|carbohydrate-binding protein 35 (human)|galactose-specific lectin 3 (human)|IgE-binding protein (human)|Mac-2 antigen (human)|CBP 35 (human)|galactoside-binding protein (human)|GALBP (human)|L-31 (human)|laminin-binding protein (human)|lectin L-29 (human)|LGALS3|gal-3 (human)	http://purl.obolibrary.org/obo/PR_P17931		
GO:0002922	biolink:BiologicalProcess	positive regulation of humoral immune response	Any process that activates or increases the frequency, rate, or extent of a humoral immune response.		hp.json	up-regulation of humoral immune response|up regulation of humoral immune response|activation of humoral immune response|stimulation of humoral immune response|upregulation of humoral immune response	http://purl.obolibrary.org/obo/GO_0002922		
CHEBI:26217	biolink:ChemicalSubstance	potassium molecular entity			hp.json	potassium molecular entity|potassium molecular entities	http://purl.obolibrary.org/obo/CHEBI_26217		3_STAR
GO:0002932	biolink:BiologicalProcess	tendon sheath development	The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.		hp.json		http://purl.obolibrary.org/obo/GO_0002932		
CHEBI:28875	biolink:ChemicalSubstance	tetradecanoic acid	A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.	LIPID_MAPS_instance:LMFA01010014|PMID:19902021|CAS:544-63-8|PMID:19154695|CAS:544-63-8|HMDB:HMDB0000806|PMID:27206979|PMID:22030224|PMID:20920594|PMID:28600633|PMID:15149689|PDBeChem:MYR|Beilstein:508624|PMID:19955401|PMID:16554156|PMID:19786012|PMID:16509590|Reaxys:508624|PMID:20634506|KEGG:C06424|Gmelin:242115|PMID:13129458|MetaCyc:CPD-7836|PMID:21955528|DrugBank:DB08231|PMID:19761868|Wikipedia:Myristic_acid|CAS:544-63-8|PMID:6802973|KNApSAcK:C00001228	hp.json	acide tetradecanoique|MYRISTIC ACID|myristic acid|Tetradecanoic acid|1-tetradecanecarboxylic acid|Myristinsaeure|14:0|n-Tetradecoic acid|n-tetradecanoic acid|14:00|CH3-[CH2]12-COOH|C14|n-Tetradecan-1-oic acid|Myristic acid|tetradecoic acid|14	http://purl.obolibrary.org/obo/CHEBI_28875		3_STAR
CHEBI:26214	biolink:ChemicalSubstance	porphyrins	Natural pigments containing a fundamental skeleton of four pyrrole nuclei united through the alpha-positions by four methine groups to form a macrocyclic structure.	Wikipedia:Porphyrin	hp.json	porphyrins	http://purl.obolibrary.org/obo/CHEBI_26214		3_STAR
CHEBI:26216	biolink:ChemicalSubstance	potassium atom		DrugBank:DB01345|KEGG:C00238|CAS:7440-09-7|WebElements:K	hp.json	19K|Kalium|potasio|kalium|K|potassium|potassium	http://purl.obolibrary.org/obo/CHEBI_26216		3_STAR
GO:0014912	biolink:BiologicalProcess	negative regulation of smooth muscle cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0014912		
GO:0014911	biolink:BiologicalProcess	positive regulation of smooth muscle cell migration	Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0014911		
GO:0014910	biolink:BiologicalProcess	regulation of smooth muscle cell migration	Any process that modulates the frequency, rate or extent of smooth muscle cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0014910		
GO:0051875	biolink:BiologicalProcess	pigment granule localization	Any process in which a pigment granule is transported to, and/or maintained in, a specific location within the cell.		hp.json	pigment granule localisation	http://purl.obolibrary.org/obo/GO_0051875		
GO:0051873	biolink:BiologicalProcess	killing by host of symbiont cells	Any process mediated by an organism that results in the death of cells in the symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.		hp.json	disruption by host of symbiont cells	http://purl.obolibrary.org/obo/GO_0051873		
GO:0000280	biolink:BiologicalProcess	nuclear division	The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.		hp.json	karyokinesis	http://purl.obolibrary.org/obo/GO_0000280		goslim_pir
CHEBI:90799	biolink:ChemicalSubstance	dipeptide zwitterion	Any peptide zwitterion comprising two amino acid residues. Major structure at pH 7.3.		hp.json	a dipeptide	http://purl.obolibrary.org/obo/CHEBI_90799		3_STAR
GO:0061205	biolink:BiologicalProcess	paramesonephric duct development	The process whose specific outcome is the progression of the paramesonephric duct over time, from its formation to the mature structure. Mullerian ducts (or paramesonephric ducts) are paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, cervix, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin.		hp.json	Mullerian duct development	http://purl.obolibrary.org/obo/GO_0061205		
GO:0036230	biolink:BiologicalProcess	granulocyte activation	The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.		hp.json		http://purl.obolibrary.org/obo/GO_0036230		
GO:0048232	biolink:BiologicalProcess	male gamete generation	Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction.		hp.json		http://purl.obolibrary.org/obo/GO_0048232		
CHEBI:133580	biolink:ChemicalSubstance	N-hexanoylglycinate	A monocarboxylic acid anion that is the conjugate base of N-hexanoylglycine, obtained by deprotonation of the carboxy group; major species at pH 7.3.		hp.json	N-hexanoylglycine|(hexanoylamino)acetate|N-hexanoylglycine anion|N-hexanoylglycine(1-)|N-caproylglycinate	http://purl.obolibrary.org/obo/CHEBI_133580		3_STAR
GO:0048243	biolink:BiologicalProcess	norepinephrine secretion	The regulated release of norepinephrine by a cell. Norepinephrine is a catecholamine and it acts as a hormone and as a neurotransmitter of most of the sympathetic nervous system.		hp.json	noradrenaline secretion	http://purl.obolibrary.org/obo/GO_0048243		
GO:0048240	biolink:NamedThing	sperm capacitation			hp.json		http://purl.obolibrary.org/obo/GO_0048240		
GO:0048247	biolink:BiologicalProcess	lymphocyte chemotaxis	The directed movement of a lymphocyte in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0048247		
GO:0048246	biolink:BiologicalProcess	macrophage chemotaxis	The movement of a macrophage in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0048246		
GO:0036211	biolink:BiologicalProcess	protein modification process	The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).		hp.json	cellular protein modification process|process resulting in protein modification|protein modification	http://purl.obolibrary.org/obo/GO_0036211		goslim_plant|goslim_pir|goslim_chembl|goslim_candida|goslim_generic|prokaryote_subset
GO:0051892	biolink:BiologicalProcess	negative regulation of cardioblast differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.		hp.json	down regulation of cardioblast differentiation|downregulation of cardioblast differentiation|inhibition of cardioblast differentiation|down-regulation of cardioblast differentiation	http://purl.obolibrary.org/obo/GO_0051892		
GO:0051890	biolink:BiologicalProcess	regulation of cardioblast differentiation	Any process that modulates the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.		hp.json		http://purl.obolibrary.org/obo/GO_0051890		
GO:0051891	biolink:BiologicalProcess	positive regulation of cardioblast differentiation	Any process that activates or increases the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.		hp.json	up-regulation of cardioblast differentiation|up regulation of cardioblast differentiation|activation of cardioblast differentiation|stimulation of cardioblast differentiation|upregulation of cardioblast differentiation	http://purl.obolibrary.org/obo/GO_0051891		
GO:0048251	biolink:BiologicalProcess	elastic fiber assembly	Assembly of the extracellular matrix fibers that enables the matrix to recoil after transient stretching.		hp.json	elastin fiber assembly|elastin fibre assembly|elastic fibre assembly	http://purl.obolibrary.org/obo/GO_0048251		
GO:0000278	biolink:BiologicalProcess	mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.	Wikipedia:Mitosis	hp.json	mitosis	http://purl.obolibrary.org/obo/GO_0000278		goslim_drosophila|goslim_chembl|goslim_yeast|goslim_generic
GO:0000272	biolink:NamedThing	polysaccharide catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0000272		
GO:0000271	biolink:BiologicalProcess	polysaccharide biosynthetic process	The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.		hp.json	polysaccharide anabolism|polysaccharide biosynthesis|glycan biosynthesis|glycan biosynthetic process|polysaccharide synthesis|polysaccharide formation	http://purl.obolibrary.org/obo/GO_0000271		
CHEBI:51151	biolink:ChemicalSubstance	dipolar compound	An  organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case.		hp.json	dipolar compounds	http://purl.obolibrary.org/obo/CHEBI_51151		3_STAR
GO:1903429	biolink:BiologicalProcess	regulation of cell maturation	Any process that modulates the frequency, rate or extent of cell maturation.		hp.json	regulation of functional differentiation	http://purl.obolibrary.org/obo/GO_1903429		
GO:1903430	biolink:BiologicalProcess	negative regulation of cell maturation	Any process that stops, prevents or reduces the frequency, rate or extent of cell maturation.		hp.json	down regulation of cell maturation|down regulation of functional differentiation|down-regulation of functional differentiation|negative regulation of functional differentiation|inhibition of cell maturation|downregulation of cell maturation|inhibition of functional differentiation|downregulation of functional differentiation|down-regulation of cell maturation	http://purl.obolibrary.org/obo/GO_1903430		
CHEBI:26191	biolink:ChemicalSubstance	polyol	A compound that contains two or more hydroxy groups.		hp.json	polyols	http://purl.obolibrary.org/obo/CHEBI_26191		3_STAR
NCBITaxon:2058185	biolink:OrganismalEntity	Dictyosteliaceae		GC_ID:1|PMID:29367151	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_2058185		
GO:0014888	biolink:BiologicalProcess	striated muscle adaptation	Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.		hp.json	striated muscle plasticity	http://purl.obolibrary.org/obo/GO_0014888		
GO:0014887	biolink:BiologicalProcess	cardiac muscle adaptation	The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.		hp.json	cardiac muscle plasticity	http://purl.obolibrary.org/obo/GO_0014887		
CHEBI:51143	biolink:ChemicalSubstance	nitrogen molecular entity		KEGG:C06061	hp.json	nitrogen molecular entities|Nitrogenous compounds|nitrogen compounds	http://purl.obolibrary.org/obo/CHEBI_51143		3_STAR
CHEBI:38166	biolink:ChemicalSubstance	organic heteropolycyclic compound			hp.json	organic heteropolycyclic compounds	http://purl.obolibrary.org/obo/CHEBI_38166		3_STAR
CHEBI:38180	biolink:ChemicalSubstance	polycyclic heteroarene			hp.json	polycyclic heteroarenes	http://purl.obolibrary.org/obo/CHEBI_38180		3_STAR
GO:1903431	biolink:BiologicalProcess	positive regulation of cell maturation	Any process that activates or increases the frequency, rate or extent of cell maturation.		hp.json	activation of functional differentiation|upregulation of functional differentiation|up-regulation of cell maturation|up regulation of cell maturation|positive regulation of functional differentiation|activation of cell maturation|up regulation of functional differentiation|upregulation of cell maturation|up-regulation of functional differentiation	http://purl.obolibrary.org/obo/GO_1903431		
GO:0014896	biolink:BiologicalProcess	muscle hypertrophy	The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.	Wikipedia:Muscle_hypertrophy	hp.json		http://purl.obolibrary.org/obo/GO_0014896		
GO:1903441	biolink:BiologicalProcess	protein localization to ciliary membrane	A process in which a protein is transported to, or maintained in, a location within a ciliary membrane.		hp.json	protein localisation to ciliary membrane|protein localization in ciliary membrane|protein localisation in ciliary membrane	http://purl.obolibrary.org/obo/GO_1903441		
GO:0014895	biolink:BiologicalProcess	smooth muscle hypertrophy	The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy.		hp.json		http://purl.obolibrary.org/obo/GO_0014895		
GO:0014897	biolink:BiologicalProcess	striated muscle hypertrophy	The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.		hp.json		http://purl.obolibrary.org/obo/GO_0014897		
GO:0048280	biolink:BiologicalProcess	vesicle fusion with Golgi apparatus	The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi.		hp.json		http://purl.obolibrary.org/obo/GO_0048280		
CHEBI:38179	biolink:ChemicalSubstance	monocyclic heteroarene			hp.json	monocyclic heteroarenes	http://purl.obolibrary.org/obo/CHEBI_38179		3_STAR
GO:0097205	biolink:NamedThing	renal filtration			hp.json		http://purl.obolibrary.org/obo/GO_0097205		
GO:0048288	biolink:BiologicalProcess	nuclear membrane fusion involved in karyogamy	The joining of 2 or more lipid bilayer membranes that surround the nucleus during the creation of a single nucleus from multiple nuclei.		hp.json	nuclear membrane fusion during karyogamy	http://purl.obolibrary.org/obo/GO_0048288		
GO:0002886	biolink:BiologicalProcess	regulation of myeloid leukocyte mediated immunity	Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.		hp.json		http://purl.obolibrary.org/obo/GO_0002886		
GO:0002887	biolink:BiologicalProcess	negative regulation of myeloid leukocyte mediated immunity	Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.		hp.json	down-regulation of myeloid leukocyte mediated immunity|down regulation of myeloid leukocyte mediated immunity|inhibition of myeloid leukocyte mediated immunity|downregulation of myeloid leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002887		
GO:0002888	biolink:BiologicalProcess	positive regulation of myeloid leukocyte mediated immunity	Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.		hp.json	upregulation of myeloid leukocyte mediated immunity|up-regulation of myeloid leukocyte mediated immunity|up regulation of myeloid leukocyte mediated immunity|activation of myeloid leukocyte mediated immunity|stimulation of myeloid leukocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002888		
GO:0048285	biolink:BiologicalProcess	organelle fission	The creation of two or more organelles by division of one organelle.		hp.json		http://purl.obolibrary.org/obo/GO_0048285		goslim_pir|goslim_yeast
GO:0000226	biolink:BiologicalProcess	microtubule cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.		hp.json	microtubule dynamics|microtubule cytoskeleton organization and biogenesis|microtubule cytoskeleton organisation	http://purl.obolibrary.org/obo/GO_0000226		goslim_pombe
GO:0048284	biolink:BiologicalProcess	organelle fusion	The creation of a single organelle from two or more organelles.		hp.json		http://purl.obolibrary.org/obo/GO_0048284		goslim_pir|goslim_yeast
OBO:MAXO_0010366	biolink:NamedThing	vaginography procedure	A radiographic examination of the vagina using the intravaginal injection of contrast medium.	NCIT:C38096	hp.json	radiography of vagina|radiograph of vagina|vaginography|vagina X-ray procedure|vagina radiogram procedure	http://purl.obolibrary.org/obo/MAXO_0010366		
CHEBI:26167	biolink:ChemicalSubstance	polar amino acid	Any amino acid whose side chain is capable of forming one or more hydrogen bonds.	PMID:12016058|MetaCyc:Polar-amino-acids	hp.json	polar amino acid|polar amino-acids|polar amino acids|polar amino-acid	http://purl.obolibrary.org/obo/CHEBI_26167		3_STAR
GO:0014861	biolink:BiologicalProcess	regulation of skeletal muscle contraction via regulation of action potential	Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.		hp.json	regulation of skeletal muscle contraction via membrane action potential	http://purl.obolibrary.org/obo/GO_0014861		
OBO:MAXO_0010360	biolink:NamedThing	bronchography procedure	The radiographic examination of the tracheobronchial tree following the injection of a radiopaque material.	NCIT:C38040	hp.json	bronchographic image procedure|tracheobronchial tree X-ray procedure|bronchography|tracheobronchial tree radiogram procedure|radiograph of tracheobronchial tree|radiography of tracheobronchial tree	http://purl.obolibrary.org/obo/MAXO_0010360		
OBO:MAXO_0010361	biolink:NamedThing	cholangiography procedure	The radiographic examination of the bile ducts after a contrast medium has been injected.	NCIT:C61508	hp.json	cholangiographic procedure|radiography of biliary tree|cholangiography|radiograph of biliary tree|biliary tree X-ray procedure|biliary tree radiogram procedure	http://purl.obolibrary.org/obo/MAXO_0010361		
OBO:MAXO_0010362	biolink:NamedThing	cystography procedure	A radiographic procedure to obtain an image of the urinary bladder by filling the bladder with contrast medium.	NCIT:C38049	hp.json	radiography of urinary bladder|cystographic imaging procedure|cystography|urinary bladder X-ray procedure|urinary bladder radiogram procedure|radiograph of urinary bladder	http://purl.obolibrary.org/obo/MAXO_0010362		
OBO:MAXO_0010363	biolink:NamedThing	mammography procedure	A type of radiography used specifically to examine breast tissue. The procedure utilizes a low-dose of x-rays or radiation to generate an image. A mammography exam or mammogram, is used as a screening tool to detect early breast cancer in women experiencing no symptoms and to detect and diagnose breast disease.	NCIT:C16818	hp.json	radiography of breast|radiograph of breast|mammography|breast X-ray procedure|breast radiogram procedure	http://purl.obolibrary.org/obo/MAXO_0010363		
GO:0014866	biolink:BiologicalProcess	skeletal myofibril assembly	The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.		hp.json		http://purl.obolibrary.org/obo/GO_0014866		
OBO:MAXO_0010364	biolink:NamedThing	myelography procedure	The radiographic examination of the spinal cord and nerve roots following the injection of a contrast medium into the spinal subarachnoid space. The X-rays taken may highlight conditions such as spinal tumors, spinal cord swelling and herniated discs.	NCIT:C20175	hp.json	spinal cord X-ray procedure|myelography|spinal cord radiogram procedure|radiograph of spinal cord|radiography of spinal cord	http://purl.obolibrary.org/obo/MAXO_0010364		
OBO:MAXO_0010365	biolink:NamedThing	total body radiography procedure	A radiologic test that involves the examination of the entire body in a single procedure.	NCIT:C96640	hp.json	radiography of multicellular organism|radiograph of multicellular organism|multicellular organism X-ray procedure|total body radiography|multicellular organism radiogram procedure|whole body radiography	http://purl.obolibrary.org/obo/MAXO_0010365		
GO:0000228	biolink:CellularComponent	nuclear chromosome	A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.		hp.json	nuclear interphase chromosome	http://purl.obolibrary.org/obo/GO_0000228		goslim_generic|goslim_chembl
CHEBI:38147	biolink:ChemicalSubstance	cardiotonic drug	A drug that has a strengthening effect on the heart or that can increase cardiac output.		hp.json	cardiotonic drugs	http://purl.obolibrary.org/obo/CHEBI_38147		3_STAR
CHEBI:38161	biolink:ChemicalSubstance	chelator	A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate.	KEGG:C02169|KEGG:C00917	hp.json	chelators|Chelating agent|complexon|chelating agents|Metal chelator	http://purl.obolibrary.org/obo/CHEBI_38161		3_STAR
OBO:MAXO_0010355	biolink:NamedThing	neck radiograph procedure	Use of an imaging test that uses small amounts of radiation to produce pictures of neck.		hp.json	radiography of neck|radiograph of neck|neck X-ray procedure|neck radiogram procedure	http://purl.obolibrary.org/obo/MAXO_0010355		
OBO:MAXO_0010356	biolink:NamedThing	chest radiograph procedure	Use of an imaging test that uses small amounts of radiation to produce pictures of chest.	NCIT:C38103	hp.json	chest X-ray procedure|chest radiogram procedure|radiograph of chest|radiography of chest	http://purl.obolibrary.org/obo/MAXO_0010356		
OBO:MAXO_0010357	biolink:NamedThing	lower limb radiographic procedure	The X-ray examination of the lower limbs of the body.	NCIT:C20080	hp.json	radiograph of lower limb segment|lower limb segment X-ray procedure|lower limb segment radiogram procedure|lower limb radiography|lower limb X-ray|radiography of lower limb segment	http://purl.obolibrary.org/obo/MAXO_0010357		
OBO:MAXO_0010358	biolink:NamedThing	angiography procedure	The X-ray examination of the blood vessels or chambers of the heart.	NCIT:C20080	hp.json	blood vasculature radiogram procedure|radiograph of blood vasculature|radiography of blood vasculature|angiography|blood vasculature X-ray procedure	http://purl.obolibrary.org/obo/MAXO_0010358		
OBO:MAXO_0010359	biolink:NamedThing	pulmonary angiography procedure	An x-ray imaging technique that involves visualization of the pulmonary vasculature after fluoroscopy-guided catheter placement and injection of an iodinated contrast medium into the pulmonary circulation.	NCIT:C154789	hp.json	radiograph of pulmonary vascular system|radiography of pulmonary vascular system|pulmonary vascular system X-ray procedure|pulmonary vascular system radiogram procedure	http://purl.obolibrary.org/obo/MAXO_0010359		
GO:0014874	biolink:BiologicalProcess	response to stimulus involved in regulation of muscle adaptation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation.		hp.json	response to stimulus involved in regulation of muscle plasticity	http://purl.obolibrary.org/obo/GO_0014874		
GO:0014872	biolink:BiologicalProcess	myoblast division	The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.		hp.json		http://purl.obolibrary.org/obo/GO_0014872		
OBO:MAXO_0010351	biolink:NamedThing	abdominal radiographic procedure	Use of an imaging test that uses small amounts of radiation to produce pictures of abdomen.	NCIT:C38102	hp.json	abdomen radiogram procedure|radiograph of abdomen|radiography of abdomen|abdominal X-ray procedure|abdominal radiography|abdomen X-ray procedure	http://purl.obolibrary.org/obo/MAXO_0010351		
OBO:MAXO_0010352	biolink:NamedThing	head radiograph procedure	Use of an imaging test that uses small amounts of radiation to produce pictures of head.		hp.json	radiography of head|radiograph of head|head X-ray procedure|head radiogram procedure	http://purl.obolibrary.org/obo/MAXO_0010352		
OBO:MAXO_0010353	biolink:NamedThing	liver radiograph procedure	Use of an imaging test that uses small amounts of radiation to produce pictures of liver.		hp.json	liver X-ray procedure|liver radiogram procedure|radiograph of liver|radiography of liver	http://purl.obolibrary.org/obo/MAXO_0010353		
OBO:MAXO_0010354	biolink:NamedThing	lung radiograph procedure	Use of an imaging test that uses small amounts of radiation to produce pictures of lung.		hp.json	radiograph of lung|lung X-ray procedure|lung radiogram procedure|radiography of lung	http://purl.obolibrary.org/obo/MAXO_0010354		
OBO:MAXO_0010308	biolink:NamedThing	oropharyngeal swab collection	Collection biological material from within the oropharynx with a cotton swab.		hp.json	swab collection of oropharynx	http://purl.obolibrary.org/obo/MAXO_0010308		
OBO:MAXO_0010309	biolink:NamedThing	anterior nares swab collection	Collection biological material from within the external naris with a cotton swab.		hp.json	swab collection of external naris|anterior naris swab	http://purl.obolibrary.org/obo/MAXO_0010309		
OBO:MAXO_0010301	biolink:NamedThing	rectal swab collection	Collection biological material from within the rectum with a cotton swab.		hp.json	swab collection of rectum|anal swab	http://purl.obolibrary.org/obo/MAXO_0010301		
OBO:MAXO_0010302	biolink:NamedThing	vaginal swab collection	Collection biological material from within the vagina with a cotton swab.		hp.json	swab collection of vagina	http://purl.obolibrary.org/obo/MAXO_0010302		
OBO:MAXO_0010303	biolink:NamedThing	buccal swab collection	Collection biological material from within the buccal mucosa with a cotton swab.		hp.json	oral swab|swab collection of buccal mucosa	http://purl.obolibrary.org/obo/MAXO_0010303		
OBO:MAXO_0010304	biolink:NamedThing	nasal turbinal swab collection	Collection biological material from within the nasal turbinal with a cotton swab.		hp.json	swab collection of nasal turbinal	http://purl.obolibrary.org/obo/MAXO_0010304		
OBO:MAXO_0010305	biolink:NamedThing	nasopharyngeal swab collection	Collection biological material from within the nasopharynx with a cotton swab.		hp.json	swab collection of nasopharynx	http://purl.obolibrary.org/obo/MAXO_0010305		
OBO:MAXO_0010306	biolink:NamedThing	nasal vestibule swab collection	Collection biological material from within the nasal vestibule with a cotton swab.		hp.json	swab collection of nasal vestibule	http://purl.obolibrary.org/obo/MAXO_0010306		
OBO:MAXO_0010307	biolink:NamedThing	skin swab collection	Collection biological material from within the zone of skin with a cotton swab.		hp.json	swab collection of zone of skin	http://purl.obolibrary.org/obo/MAXO_0010307		
CHEBI:90710	biolink:ChemicalSubstance	receptor modulator	A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors.		hp.json	receptor modulators	http://purl.obolibrary.org/obo/CHEBI_90710		3_STAR
CHEBI:77746	biolink:ChemicalSubstance	human metabolite	Any mammalian metabolite  produced during a metabolic reaction in humans (Homo sapiens).		hp.json	Homo sapiens metabolites|H. sapiens metabolites|H. sapiens metabolite|Homo sapiens metabolite	http://purl.obolibrary.org/obo/CHEBI_77746		3_STAR
HP:0011593	biolink:PhenotypicFeature	Left aortic arch with retroesophageal diverticulum of Kommerell	A patent ductus arteriosus or ductal ligament completes the ring.	UMLS:C0265885|SNOMEDCT_US:74561007	hp.json	Kommerell diverticulum	http://purl.obolibrary.org/obo/HP_0011593		
HP:0011594	biolink:PhenotypicFeature	Right aortic arch with retroesophageal diverticulum of Kommerell	Aortic arch crosses the right mainstem bronchus. The left carotid artery is the first branch, right carotid artery the second branch and right subclavian artery as the third branch.	UMLS:C4023279	hp.json		http://purl.obolibrary.org/obo/HP_0011594		
HP:0011595	biolink:PhenotypicFeature	Left aortic arch with retroesophageal right subclavian artery	Aortic arch crosses the left mainstem bronchus. The first branch is the right carotid artery, the second branch is the left carotid artery, the third branch is the subclavian artery, the fourth branch is the right subclavian artery arising from the posteromedial aspect of the distal aortic arch and continuing posterior to the esophagus to the right hand side of the body.	UMLS:C4023278	hp.json		http://purl.obolibrary.org/obo/HP_0011595		
HP:0011596	biolink:PhenotypicFeature	Left aortic arch with right descending aorta and right ductus arteriosus	The ring may be completed by the ductal ligament.	UMLS:C4023277	hp.json		http://purl.obolibrary.org/obo/HP_0011596		
HP:0011597	biolink:PhenotypicFeature	Right aortic arch with left descending aorta and left ductus arteriosus		UMLS:C4023276	hp.json		http://purl.obolibrary.org/obo/HP_0011597		
HP:0011598	biolink:PhenotypicFeature	Right aortic arch with retroesophageal left subclavian artery		UMLS:C4021140	hp.json	Right aortic arch with anomalous left subclavian artery|Right aortic arch with aberrant left subclavian artery	http://purl.obolibrary.org/obo/HP_0011598		
HP:0011599	biolink:PhenotypicFeature	Mesocardia	Mesocardia is an abnormal location of the heart in which the heart is in a midline position and the longitudinal axis of the heart lies in the mid-sagittal plane.	SNOMEDCT_US:16567006|Fyler:140|Fyler:0140|UMLS:C0265865	hp.json		http://purl.obolibrary.org/obo/HP_0011599		
HP:0011590	biolink:PhenotypicFeature	Double aortic arch	A conenital abnormality of the aortic arch in which the two embryonic aortc arches form a vascular ring that surrounds the trachea or esophagus and then join to form the descending aorta. Double aortic arch can cause symptoms because of compression of the esophagus (dysphagia, cyanosis while eating) or trachea (stridor).	Fyler:2761|SNOMEDCT_US:10451007|UMLS:C0265883	hp.json		http://purl.obolibrary.org/obo/HP_0011590		
HP:0011591	biolink:PhenotypicFeature	Left aortic arch with cervical origin of the right subclavian artery		UMLS:C4023281	hp.json		http://purl.obolibrary.org/obo/HP_0011591		
HP:0011592	biolink:PhenotypicFeature	Left aortic arch with isolated subclavian artery	The subclavian artery arises from ductus arteriosus. While the ductus arteriosus is patent its blood supply comes from the ductus, hence from the pulmonary artery. After it closes, the blood supply is retrogradely from the vertebral artery via the circle of Willis.	UMLS:C4023280	hp.json		http://purl.obolibrary.org/obo/HP_0011592		
OBO:MAXO_0010320	biolink:NamedThing	CT pulmonary angiogram	The use of computed tomography to produce images of structures of the pulmonary vascular system.		hp.json	CT PE|CT scan for pulmonary embolism|pulmonary vascular system CT examination|CAT scan of pulmonary vascular system|pulmonary vascular system computerized axial tomography|pulmonary vascular system computed tomography|pulmonary vascular system CAT scan|CT of pulmonary vascular system	http://purl.obolibrary.org/obo/MAXO_0010320		
HP:0011582	biolink:PhenotypicFeature	Abdominal ectopia cordis	Displacement of the heart outside the thoracic cavity and into the abdomen.	UMLS:C4023287	hp.json		http://purl.obolibrary.org/obo/HP_0011582		
OBO:MAXO_0010319	biolink:NamedThing	CT angiogram	The use of computed tomography to produce images of structures of the blood vasculature.		hp.json	blood vasculature CAT scan|blood vasculature computed tomography|blood vasculature CT examination|CT of blood vasculature|blood vasculature computerized axial tomography|CAT scan of blood vasculature	http://purl.obolibrary.org/obo/MAXO_0010319		
HP:0011583	biolink:PhenotypicFeature	Cervical ectopia cordis	A type of ectopia cordis with the heart partially in the cervical region and without a defect of the sternum.	UMLS:C4023286	hp.json		http://purl.obolibrary.org/obo/HP_0011583		
HP:0011584	biolink:PhenotypicFeature	Thoracocervical ectopia cordis	A type of ectopia cordis with the heart partially in the cervical region with a defect of the superior portion of the sternum.	UMLS:C4023285	hp.json		http://purl.obolibrary.org/obo/HP_0011584		
HP:0011585	biolink:PhenotypicFeature	Thoracic ectopia cordis	Congenital malformation of the thoracic wall with partial or total displacement of the heart outside the thoracic cavity. This feature is associated with sternal cleft or absence of the sternum.	UMLS:C4023284	hp.json		http://purl.obolibrary.org/obo/HP_0011585		
HP:0011586	biolink:PhenotypicFeature	Thoracoabdominal ectopia cordis	Congenital malformation of the ventral wall with partial or total evisceration of the heart outside the thoracic cavity and displacement partially into the abdominal cavity.	UMLS:C4023283	hp.json		http://purl.obolibrary.org/obo/HP_0011586		
HP:0011587	biolink:PhenotypicFeature	Abnormal branching pattern of the aortic arch	A deviance from the norm of the origin or course of the right brachiocephalic artery, the left common carotid artery, the left subclavian artery or the proximal vertebral arteries.	UMLS:C4023282	hp.json		http://purl.obolibrary.org/obo/HP_0011587		
HP:0011588	biolink:PhenotypicFeature	Cervical aortic arch	The aortic arch extends into the soft tissues of the neck before turning down into to become the descending aorta.	SNOMEDCT_US:253657003|UMLS:C0345065	hp.json		http://purl.obolibrary.org/obo/HP_0011588		
HP:0011589	biolink:PhenotypicFeature	Common origin of the right brachiocephalic artery and left common carotid artery	The left common carotid artery has a common origin with the innominate artery.	SNOMEDCT_US:460890003|UMLS:C4021141|UMLS:C4020746|UMLS:C3532020	hp.json	Bovine arch|Common brachiocephalic trunk|Ovine arch	http://purl.obolibrary.org/obo/HP_0011589		
OBO:MAXO_0010311	biolink:NamedThing	abdominal CT	The use of computed tomography to produce images of structures of the abdomen.		hp.json	abdomen computed tomography|CT of abdomen|abdomen CAT scan|CAT scan of abdomen|abdomen computerized axial tomography|abdomen CT examination	http://purl.obolibrary.org/obo/MAXO_0010311		
OBO:MAXO_0010312	biolink:NamedThing	head CT	The use of computed tomography to produce images of structures of the head.		hp.json	head CAT scan|head CT examination|head computerized axial tomography|CAT scan of head|head computed tomography|CT of head	http://purl.obolibrary.org/obo/MAXO_0010312		
OBO:MAXO_0010313	biolink:NamedThing	liver CT	The use of computed tomography to produce images of structures of the liver.		hp.json	CAT scan of liver|liver computerized axial tomography|liver computed tomography|liver CAT scan|liver CT examination|CT of liver	http://purl.obolibrary.org/obo/MAXO_0010313		
OBO:MAXO_0010314	biolink:NamedThing	lung CT	The use of computed tomography to produce images of structures of the lung.		hp.json	lung CAT scan|CAT scan of lung|lung computerized axial tomography|lung CT examination|lung computed tomography|CT of lung	http://purl.obolibrary.org/obo/MAXO_0010314		
OBO:MAXO_0010315	biolink:NamedThing	neck CT	The use of computed tomography to produce images of structures of the neck.		hp.json	neck CAT scan|neck CT examination|CAT scan of neck|neck computerized axial tomography|neck computed tomography|CT of neck	http://purl.obolibrary.org/obo/MAXO_0010315		
OBO:MAXO_0010316	biolink:NamedThing	brain CT	The use of computed tomography to produce images of structures of the brain.		hp.json	brain computerized axial tomography|CAT scan of brain|brain CAT scan|brain computed tomography|CT of brain|brain CT examination	http://purl.obolibrary.org/obo/MAXO_0010316		
OBO:MAXO_0010317	biolink:NamedThing	chest CT	The use of computed tomography to produce images of structures of the chest.		hp.json	CT of chest|chest CAT scan|CAT scan of chest|chest CT examination|chest computerized axial tomography|chest computed tomography	http://purl.obolibrary.org/obo/MAXO_0010317		
HP:0011580	biolink:PhenotypicFeature	Short chordae tendineae of the mitral valve	Abnormally short chordae tendineae of the mitral valve.	UMLS:C4023288	hp.json		http://purl.obolibrary.org/obo/HP_0011580		
OBO:MAXO_0010318	biolink:NamedThing	skull CT	The use of computed tomography to produce images of structures of the skull.		hp.json	skull CAT scan|skull computed tomography|skull CT examination|CT of skull|skull computerized axial tomography|CAT scan of skull	http://purl.obolibrary.org/obo/MAXO_0010318		
HP:0011581	biolink:PhenotypicFeature	Double outlet left ventricle	A congenital defect of heart development characterized by origin of both pulmonary artery and aorta from the morphological left ventricle.	UMLS:C0265809|Fyler:0650|SNOMEDCT_US:7368005|Fyler:650|ICD-10:Q20.2	hp.json		http://purl.obolibrary.org/obo/HP_0011581		
OBO:MAXO_0010310	biolink:NamedThing	throat swab collection	Collection biological material from within the throat with a cotton swab.		hp.json	swab collection of throat	http://purl.obolibrary.org/obo/MAXO_0010310		
UBERON:0035480	biolink:AnatomicalEntity	surface of prostate	The external portion of the prostate including the anterior, inferolateral, lateral and posterior surfaces.	NCIT:C13091|FMA:19590	hp.json	surface of prostate gland|prostatic surface	http://purl.obolibrary.org/obo/UBERON_0035480		
UBERON:0035483	biolink:AnatomicalEntity	left suprarenal vein	A vein that drains blood from the left adrenal gland into the left renal artery.	NCIT:C53138|FMA:14349	hp.json		http://purl.obolibrary.org/obo/UBERON_0035483		human_reference_atlas
UBERON:0035489	biolink:AnatomicalEntity	branch of basilar artery		FMA:76269|NCIT:C32195	hp.json	basilar arterial branch	http://purl.obolibrary.org/obo/UBERON_0035489		
CHEBI:63137	biolink:ChemicalSubstance	4-hydroxyproline zwitterion	The amino acid zwitterion formed from 4-hydroxyproline.		hp.json	4-hydroxypyrrolidinium-2-carboxylate	http://purl.obolibrary.org/obo/CHEBI_63137		3_STAR
OBO:MAXO_0000936	biolink:NamedThing	alkaline phosphatase enzyme activity test	Measurement of alkaline phosphatase enzamatic activity in a biological sample.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000936		
OBO:MAXO_0000937	biolink:NamedThing	inorganic pyrophosphate measurement	The determination of the amount of inorganic pyrophosphate present in a sample.	NCIT:C161358	hp.json	PPI measurement|PPi measurement	http://purl.obolibrary.org/obo/MAXO_0000937		
OBO:MAXO_0000931	biolink:NamedThing	psychologist evaluation	An initial assessment by a person who specializes in the study of mind and behavior or in the treatment of mental, emotional, and behavioral disorders.	NCIT:C28181	hp.json		http://purl.obolibrary.org/obo/MAXO_0000931		
OBO:MAXO_0000934	biolink:NamedThing	urine phosphoethanolamine measurement	Detection of phosphoethanolamine in urine.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000934		
OBO:MAXO_0000935	biolink:NamedThing	bone specific alkaline phosphatase measurement	The determination of the amount of bone specific alkaline phosphatase present in a sample.	NCIT:C92287	hp.json	ALPBS test|bone ALP measurement	http://purl.obolibrary.org/obo/MAXO_0000935		
OBO:MAXO_0000932	biolink:NamedThing	electroencephalography	The neurophysiologic exploration of the electrical activity of the brain by the application of electrodes to the scalp. The resulting traces are known as an electroencephalogram (EEG). This test is used to assess brain damage, epilepsy and other problems.	NCIT:C38054	hp.json	EEG	http://purl.obolibrary.org/obo/MAXO_0000932		
UBERON:3011048	biolink:AnatomicalEntity	genital system	Anatomical system that has as its parts the organs concerned with reproduction, especially the external genital organs.		hp.json	reproductive system|genitalia	http://purl.obolibrary.org/obo/UBERON_3011048		
GO:0048209	biolink:BiologicalProcess	regulation of vesicle targeting, to, from or within Golgi	Any process that modulates the frequency, rate, or destination of vesicle-mediated transport to, from or within the Golgi apparatus.		hp.json	regulation of Golgi vesicle targeting	http://purl.obolibrary.org/obo/GO_0048209		
CHEBI:63161	biolink:ChemicalSubstance	glycosyl compound	A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity.		hp.json	glycosyl compounds	http://purl.obolibrary.org/obo/CHEBI_63161		3_STAR
UBERON:0001789	biolink:AnatomicalEntity	outer nuclear layer of retina	The layer within the retina where the photoreceptor cell bodies reside.	BTO:0005600|XAO:0003219|MA:0001315|BAMS:Ronl|FMA:58684|UMLS:C0229210|ZFA:0001464|NCIT:C33236|EMAPA:19157|VHOG:0001170|TAO:0001464	hp.json	retinal outer nuclear layers|stratum nucleare externum retinae|outer nuclear layer|layer of outer granules|neural retina outer nuclear layer|retinal outer nuclear layer|ONL|stratum nucleare externum (retina)|retina, outer nuclear layer|retina outer nuclear layer|external nuclear layer	http://purl.obolibrary.org/obo/UBERON_0001789		pheno_slim|human_reference_atlas|vertebrate_core
UBERON:0001788	biolink:AnatomicalEntity	outer limiting layer of retina	The row of jucntional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier[MP].	TAO:0001331|MA:0001309|FMA:58683|UMLS:C1518685|XAO:0003224|NCIT:C33235|ZFA:0001331|EMAPA:36518	hp.json	BRB|retina outer limiting membrane|outer limiting membranes|external limiting membrane|blood retina barrier|stratum limitans externum retinae|retina external limiting lamina|stratum limitans externum (retina)|external limiting lamina of retina|outer limiting membrane|external limiting membrane of retina|outer limiting membrane of retina	http://purl.obolibrary.org/obo/UBERON_0001788		pheno_slim|vertebrate_core
HP:0033565	biolink:PhenotypicFeature	Anti-epidermal transglutaminase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against epidermal transglutaminase.		hp.json	Anti-TG3 antibody|Anti-epidermal transglutaminase (anti-eTG) antibody|Anti-keratinocyte transglutaminase|Anti-eTG antibody positivity	http://purl.obolibrary.org/obo/HP_0033565		
UBERON:0013774	biolink:AnatomicalEntity	diaphysis of metatarsal bone	A diaphysis that is part of a metatarsal bone.	FMA:33826	hp.json	metatarsal diaphysis|metatarsal bone diaphysis|diaphysis of metatarsal|shaft of metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0013774		pheno_slim
UBERON:0011111	biolink:AnatomicalEntity	humeroradial joint	A hinge joint between the head of the radius and the capitulum of the humerus.	FMA:38855	hp.json	humero-radial joint|articulatio humeroradialis	http://purl.obolibrary.org/obo/UBERON_0011111		pheno_slim
UBERON:0011110	biolink:AnatomicalEntity	humeroulnar joint	The humeroulnar joint, is part of the elbow-joint or the Olecron Joint, between the ulna and humerus bones is the simple hinge-joint, which allows for movements of flexion, extension and circumduction. The Humero-Ulnar Joint is the junction of trochlear notch of the ulna and the trochlea of the humerus. Owing to the obliquity of the trochlea of the humerus, this movement does not take place in the antero-posterior plane of the body of the humerus. When the forearm is extended and supinated, the axis of the arm and forearm are not in the same line; the arm forms an obtuse angle with the forearm. During flexion, however, the forearm and the hand tend to approach the middle line of the body, and thus enable the hand to be easily carried to the face. The accurate adaptation of the trochlea of the humerus, with its prominences and depressions, to the semilunar notch of the ulna, prevents any lateral movement. Flexion is produced by the action of the Biceps brachii and Brachialis, assisted by the Brachioradialis, with a tiny contribution from the muscles arising from the medial epicondyle of the humerus. Extension is produced by the Triceps brachii and AnconC&us, with a tiny contribution from the muscles arising from the lateral epicondyle of the humerus, such as the Extensor digitorum communis.	FMA:38854	hp.json	articulatio humeroulnaris|humero-ulnar joint	http://purl.obolibrary.org/obo/UBERON_0011110		pheno_slim
HP:0033564	biolink:PhenotypicFeature	Stasis dermatitis	Stasis dermatitis commonly occurs in older age. It is caused by venous hypertension resulting from retrograde flow due to incompetent venous valves, valve destruction, or obstruction of the venous system. Further tissue changes arise from an inflammatory process mediated by metalloproteinases, which are up-regulated by ferric ion from extravasated red blood cells. Stasis dermatitis presents initially as poorly demarcated erythematous plaques of the lower legs bilaterally, classically involving the medial malleolus.		hp.json	Venous eczema|Varicose eczema	http://purl.obolibrary.org/obo/HP_0033564		
UBERON:0013776	biolink:AnatomicalEntity	skin of palmar/plantar part of autopod	A zone of skin that is part of a palmar/plantar part of autopod.		hp.json		http://purl.obolibrary.org/obo/UBERON_0013776		
HP:0033567	biolink:PhenotypicFeature	Right axis deviation	A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between +90 degrees and 180 degrees, or beyond +100 degrees if the adult range is used.		hp.json	RAD|Electrical right axis deviation	http://purl.obolibrary.org/obo/HP_0033567		
UBERON:0013777	biolink:AnatomicalEntity	skin of palm of manus	A zone of skin that is part of a palmar part of manus.	FMA:38301	hp.json	palmar skin of hand|skin of palmar area of hand	http://purl.obolibrary.org/obo/UBERON_0013777		pheno_slim
HP:0033566	biolink:PhenotypicFeature	Abnormal ventricular axis	Any deviation from the normal direction of the ventricular axis. The left ventricle makes up most of the heart muscle under normal circumstances and therefore generates the most electrical force visible on the EKG. The normal ventricular axis is directed downward and slightly towards the left. The ventricular axis can be determined by analyzing the QRS complex, which represents ventricular depolarization.		hp.json	Abnormal QRS axis	http://purl.obolibrary.org/obo/HP_0033566		
HP:0033561	biolink:PhenotypicFeature	Anti-bactericidal/permeability-increasing protein antibody positivity	The presence of autoantibodies in the blood circulation that react against bactericidal/permeability-increasing protein (BPI). BPI is an endotoxin-binding host protein with important antibacterial effects against Gram-negative bacteria, such as Pseudomonas aeruginosa.  BPI is a 55 kDalton protein that is most abundant in the azurophilic granules of neutrophils. BPI also acts as a target antigen for antineutrophil cytoplasmic autoantibodies.		hp.json	Anti-BPI antibody positivity	http://purl.obolibrary.org/obo/HP_0033561		
HP:0033560	biolink:PhenotypicFeature	Anti-PM-Scl antibody positivity	Anti-PM-Scl antibodies target components of RNA-processing exosome complex in the nucleolus. There are ten proteins in this complex and antibodies to eight of them are found at varying frequencies; PM/Scl-100, PM/Scl-75, hRrp4, hRrp42, hRrp46, hCs14, hRrp41, and hRrp40.		hp.json	Anti-PM/Scl antibody positivity	http://purl.obolibrary.org/obo/HP_0033560		
UBERON:0013771	biolink:AnatomicalEntity	line connecting laterally paired nipples	Line across midline connecting a left and right nipples.		hp.json	intermammary line	http://purl.obolibrary.org/obo/UBERON_0013771		
HP:0033563	biolink:PhenotypicFeature	Anti-tissue transglutaminase antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against tissue transglutaminase.		hp.json	Anti-tTG antibody positivity	http://purl.obolibrary.org/obo/HP_0033563		
UBERON:0013772	biolink:AnatomicalEntity	left nipple	A nipple that is in_the_left_side_of a body proper.	FMA:223695	hp.json		http://purl.obolibrary.org/obo/UBERON_0013772		pheno_slim
UBERON:0011112	biolink:AnatomicalEntity	tibiofibular joint	A joint that connects the tibia and the fibula.	FMA:35181	hp.json	fibulatibial joint|tibiafibular joint|fibulotibial joint	http://purl.obolibrary.org/obo/UBERON_0011112		
UBERON:0013773	biolink:AnatomicalEntity	right nipple	A nipple that is in_the_right_side_of a body proper.	FMA:223693	hp.json		http://purl.obolibrary.org/obo/UBERON_0013773		pheno_slim
HP:0033562	biolink:PhenotypicFeature	Anti-glycoprotein-210 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against glycoprotein-210.		hp.json	Anti-gp210 antibody positivity	http://purl.obolibrary.org/obo/HP_0033562		
CHEBI:61313	biolink:ChemicalSubstance	C21-steroid	A steroid that has a structure based on a 21-carbon (pregnane) skeleton. Note that individual examples may have ring substituents at other positions and/or contain double bonds, aromatic A-rings, expanded/contracted rings etc., so the formula and mass may vary from that given for the generic structure.		hp.json	a C21-steroid	http://purl.obolibrary.org/obo/CHEBI_61313		3_STAR
UBERON:0011108	biolink:AnatomicalEntity	synovial joint of pectoral girdle	A synovial joint that is part of a pectoral girdle region.	FMA:35243	hp.json	joint of shoulder girdle|pectoral girdle joint	http://purl.obolibrary.org/obo/UBERON_0011108		
UBERON:0011107	biolink:AnatomicalEntity	synovial joint of pelvic girdle	A synovial joint that is part of a pelvic girdle region.	UMLS:C0827002|NCIT:C32890|FMA:35173	hp.json	pelvic girdle joint|joint of pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0011107		
CHEBI:36347	biolink:ChemicalSubstance	nuclear particle	A nucleus or any of its constituents in any of their energy states.		hp.json	nuclear particle	http://purl.obolibrary.org/obo/CHEBI_36347		3_STAR
UBERON:0001790	biolink:AnatomicalEntity	outer plexiform layer of retina	The layer within the retina where the bipolar cells synapse with the photoreceptor cells[ZFA]. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells[GO].	XAO:0003218|MA:0001316|UMLS:C0229217|FMA:58685|BTO:0003174|BAMS:Ropl|NCIT:C33237|VHOG:0001171|ZFA:0001330|TAO:0001330|EMAPA:35744	hp.json	external plexiform layer|OPL|stratum plexiforme externum retinae|stratum plexiforme externum|outer plexiform layer|retinal outer plexiform layers|retinal outer plexiform layer|retina, outer plexiform layer|retina outer plexiform layer	http://purl.obolibrary.org/obo/UBERON_0001790		vertebrate_core|pheno_slim
CHEBI:36344	biolink:ChemicalSubstance	hadron	Hadron is a subatomic particle which experiences the strong force.		hp.json	hadrons	http://purl.obolibrary.org/obo/CHEBI_36344		3_STAR
UBERON:0013767	biolink:AnatomicalEntity	frontal process of maxilla	A plate of bone from the maxilla that that projects upward, medialward, and backward, by the side of the nose, forming part of its lateral boundary[WP,modified].	FMA:52894	hp.json	frontal process of the maxilla|nasal process of maxilla|frontal appendage of maxilla|processus frontalis (maxilla)|processus frontalis maxillae	http://purl.obolibrary.org/obo/UBERON_0013767		
HP:0033569	biolink:PhenotypicFeature	Extreme axis deviation	A kind of abnormal ventricular axis in the EKG whereby the QRS axis fall sbetween -90 degrees and 180 degrees. In this case, the ventricular vector is directed upward and to the right.		hp.json		http://purl.obolibrary.org/obo/HP_0033569		
HP:0033568	biolink:PhenotypicFeature	Left axis deviation	A kind of abnormal ventricular axis in the EKG whereby the QRS axis falls between -30 degrees and -90 degrees.		hp.json	Electrical left axis deviation	http://purl.obolibrary.org/obo/HP_0033568		
UBERON:0013768	biolink:AnatomicalEntity	great vessel of heart	Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart.	Wikipedia:Great_vessels|SCTID:304066000|EMAPA:36460	hp.json	great vessel of thorax|great vessel	http://purl.obolibrary.org/obo/UBERON_0013768		grouping_class
UBERON:0013769	biolink:AnatomicalEntity	uterine lumen	An organ cavity that is part of a uterus.	Wikipedia:Uterine_cavity|FMA:17745|EMAPA:36273	hp.json	uterine space|cavity of uterus|uterine cavity	http://purl.obolibrary.org/obo/UBERON_0013769		
UBERON:0001796	biolink:AnatomicalEntity	aqueous humor of eyeball	A thick watery refractive medium that fills the space between the lens and the cornea[WP].	OpenCyc:Mx4rvdGd-5wpEbGdrcN5Y29ycA|SCTID:280587006|MESH:D001082|Wikipedia:Aqueous_humor|EHDAA2:0000139|MA:0001236|FMA:58819|NCIT:C13190|ENVO:02000024|UMLS:C0003662|GAID:890|EMAPA:18232|ZFA:0005564|VHOG:0000548|EHDAA:10196	hp.json	humor aquosus|aqueous humour|aqueous humor	http://purl.obolibrary.org/obo/UBERON_0001796		uberon_slim|vertebrate_core|pheno_slim
HP:0008598	biolink:PhenotypicFeature	Mild conductive hearing impairment	A mild form of conductive hearing impairment.	UMLS:C4021536	hp.json	Conductive hearing loss, mild	http://purl.obolibrary.org/obo/HP_0008598		
UBERON:0001795	biolink:AnatomicalEntity	inner plexiform layer of retina	Cytoarchitectural layer of the retina that is made up of a dense reticulum of fibrils formed by interlaced dendrites of retinal ganglion cells and cells of the inner nuclear layer (adapted from Wikipedia).	ZFA:0001329|EMAPA:35741|VHOG:0001168|TAO:0001329|BTO:0003175|XAO:0003225|UMLS:C0229221|MA:0001312|NLXANAT:1005032|NLX:20558|NCIT:C32809|FMA:58704|BAMS:Ripl	hp.json	retinal inner plexiform layer|inner plexiform layer|internal plexiform layer of retina|stratum plexifome internum|retina inner plexiform layer|retinal internal plexiform layer|retina, inner plexiform layer|IPL|stratum plexiforme internum|stratum plexiforme internum retinae	http://purl.obolibrary.org/obo/UBERON_0001795		vertebrate_core|pheno_slim
UBERON:0001798	biolink:AnatomicalEntity	vitreous body	Gelatinous mucoid tissue that is composed of vitreous humor and fills the cavity behind the crystalline lens of the eye and in front of the retina[MP,modified].	UMLS:C0042905|MESH:D014822|GAID:919|NCIT:C33884|FMA:58827|CALOHA:TS-0308|MA:0002462	hp.json		http://purl.obolibrary.org/obo/UBERON_0001798		uberon_slim|pheno_slim
UBERON:0001797	biolink:AnatomicalEntity	vitreous humor	A transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina.	FMA:58822|VHOG:0000795|BTO:0001451|UMLS:C0229096|CALOHA:TS-0308|NCIT:C13323|ENVO:02000032|MA:0001286|EV:0100344|ZFA:0005561|OpenCyc:Mx4rv7ZIfZwpEbGdrcN5Y29ycA|EMAPA:17837	hp.json	humor vitreous|vitreous|humoral fluid|portion of vitreous humor|ocular fluid|whole portion of vitreous humor|vitreous humour|vitreous fluid|humor vitreus	http://purl.obolibrary.org/obo/UBERON_0001797		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001792	biolink:AnatomicalEntity	ganglionic layer of retina	Cytoarchitectural layer of retina that contains somata of retinal ganglion cells, bounded by the stratum opticum and the inner plexiform layer.	BAMS:Rgcl|NLX:36500|BTO:0003398|FMA:58687|VHOG:0001166|ZFA:0000024|XAO:0003223|MA:0001310|NCIT:C32652|EMAPA:35739|TAO:0000024|NLXANAT:1005030|CALOHA:TS-0867	hp.json	stratum ganglionicum (retina)|GCL layer|retina ganglion cell layer|retina, ganglion cell layer|RGC layer|ganglionic cell layer of retina|retinal ganglion layer|ganglion cell layer|stratum ganglionicum retinae|retinal ganglion cell layer|retina ganglion layer	http://purl.obolibrary.org/obo/UBERON_0001792		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas
CHEBI:36342	biolink:ChemicalSubstance	subatomic particle	A particle smaller than an atom.	Wikipedia:Subatomic_particle	hp.json	subatomic particles	http://purl.obolibrary.org/obo/CHEBI_36342		3_STAR
UBERON:0001791	biolink:AnatomicalEntity	inner nuclear layer of retina	Cytoarchitectural layer of retina containing closely packed cell bodies, the majority of which are bipolar cells (adapted from Wikipedia).	FMA:58686|TAO:0000119|VHOG:0001167|BTO:0003176|MA:0001311|XAO:0003221|BAMS:Rinl|NLXANAT:1005031|EMAPA:19155|NCIT:C32808|UMLS:C0229211|ZFA:0000119|NLX:93816	hp.json	neural retina inner nuclear layer|retina, inner nuclear layer|retinal inner nuclear layer|INL|inner nuclear layer|layer of inner granules|intermediate cell layer|retina inner nuclear layer|stratum nucleare internum retinae|stratum nucleare internum	http://purl.obolibrary.org/obo/UBERON_0001791		vertebrate_core|pheno_slim|human_reference_atlas
HP:0008593	biolink:PhenotypicFeature	Prominent antitragus	Increased anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix.	UMLS:C1968811	hp.json	Enlarged antitragus|Hyperplastic antitragus|Hypertrophic antitragus	http://purl.obolibrary.org/obo/HP_0008593		
CHEBI:36343	biolink:ChemicalSubstance	composite particle	A subatomic particle known to have substructure (i.e. consisting of smaller particles).		hp.json	composite particles	http://purl.obolibrary.org/obo/CHEBI_36343		3_STAR
UBERON:0001794	biolink:AnatomicalEntity	inner limiting layer of retina	The row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous[MP].	FMA:58689|ZFA:0001029|MA:0001313|TAO:0001029|XAO:0003222|EMAPA:36519|UMLS:C1512783|NCIT:C32807	hp.json	retina inner limiting membrane|retina internal limiting lamina|internal limiting lamina of retina|internal limiting membrane of retina|inner limiting membranes|ILM|stratum limitans internum retinae|inner limiting membrane|inner limiting membrane of retina	http://purl.obolibrary.org/obo/UBERON_0001794		vertebrate_core|pheno_slim
CHEBI:36340	biolink:ChemicalSubstance	fermion	Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi.		hp.json	fermion|fermions	http://purl.obolibrary.org/obo/CHEBI_36340		3_STAR
HP:0008596	biolink:PhenotypicFeature	Postlingual sensorineural hearing impairment	A form of sensorineural hearing impairment with onset after the acquisition of speech.	UMLS:C4024654	hp.json		http://purl.obolibrary.org/obo/HP_0008596		
UBERON:0001793	biolink:AnatomicalEntity	nerve fiber layer of retina	Layer of the retina formed by expansion of the fibers of the optic nerve.	FMA:58688|VHOG:0001169|MA:0001314|DMBA:15652|XAO:0003220|TAO:0002212|ZFA:0001619|EMAPA:18591	hp.json	stratum opticum of retina|layer of nerve fibres of retina|optic fiber layer|stratum neurofibrarum (retina)|retina nerve fiber layer|stratum neurofibrarum retinae|neural retina nerve fibre layer|optic fiber layer|optic fiber layers|stratum neurofibrum retinae|layer of nerve fibers of retina|nerve fiber layer	http://purl.obolibrary.org/obo/UBERON_0001793		vertebrate_core|pheno_slim
CHEBI:36341	biolink:ChemicalSubstance	boson	Particle of integer spin quantum number following Bose-Einstein statistics. Bosons are named after Satyendra Nath Bose.		hp.json	bosons|boson	http://purl.obolibrary.org/obo/CHEBI_36341		3_STAR
HP:0033570	biolink:PhenotypicFeature	Indeterminate ventricular axis	A kind of abnormal ventricular axis in the EKG whereby the QRS complex is isoelectric or equiphasic in all leads with no dominant QRS deflection.		hp.json		http://purl.obolibrary.org/obo/HP_0033570		
UBERON:0001778	biolink:AnatomicalEntity	ciliary epithelium	A double layer covering the ciliary body that produces aqueous humor.	EMAPA:35239|Wikipedia:Ciliary_body#Ciliary_epithelium|UMLS:C0459736|BTO:0001770|SCTID:280870004|MA:0001238|CALOHA:TS-0695|FMA:58464|NCIT:C32314	hp.json	ocular ciliary epithelium|epithelium of ciliary body|ciliary body epithelium	http://purl.obolibrary.org/obo/UBERON_0001778		human_reference_atlas
UBERON:0001777	biolink:AnatomicalEntity	substantia propria of cornea	The lamellated connective tissue of the cornea between the Bowman and Descemet membranes.	UMLS:C0010040|TAO:0002189|FMA:58306|CALOHA:TS-1138|EMAPA:17602|MESH:D003319|SCTID:362511000|GAID:893|ZFA:0001685|Wikipedia:Corneal_stroma|NCIT:C12699|MA:0001245|EFO:0002514	hp.json	substantia propria|substantia propria corneae|stroma of cornea|corneal stroma	http://purl.obolibrary.org/obo/UBERON_0001777		pheno_slim|efo_slim|uberon_slim|vertebrate_core
dc:description	biolink:NamedThing	description		http://purl.org/dc/elements/1.1/description	hp.json		http://purl.org/dc/elements/1.1/description		
UBERON:0001779	biolink:AnatomicalEntity	iris stroma	The delicate vascular connective tissue that lies between the anterior surface of the iris and the pars iridica retinae.	FMA:58526|SCTID:280882008|MA:0002777|EMAPA:35451|ZFA:0005569|Wikipedia:Iris_stroma	hp.json	iridial stroma|stroma of iris	http://purl.obolibrary.org/obo/UBERON_0001779		pheno_slim|uberon_slim|vertebrate_core
HP:0033576	biolink:PhenotypicFeature	Anti-H2B antibody positivity	The presence of autoantibodies in the blood circulation that react against histone H2B.		hp.json		http://purl.obolibrary.org/obo/HP_0033576		
HP:0033575	biolink:PhenotypicFeature	Anti-H2A antibody positivity	The presence of autoantibodies in the blood circulation that react against histone H2A.		hp.json		http://purl.obolibrary.org/obo/HP_0033575		
UBERON:0013765	biolink:AnatomicalEntity	digestive system element	Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements.	EMAPA:37843|SCTID:272627002	hp.json	digestive organ|digestive system organ	http://purl.obolibrary.org/obo/UBERON_0013765		pheno_slim|grouping_class
HP:0033578	biolink:PhenotypicFeature	Pre-capillary pulmonary hypertension	Pre-capillary pulmonary hypertension is a haemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary vascular resistance (PVR 3 Wood units or more) accompanied by normal pulmonary artery wedge pressure (PAWP not more than 15 mmHg).		hp.json	Precapillary pulmonary hypertension	http://purl.obolibrary.org/obo/HP_0033578		
UBERON:0013766	biolink:AnatomicalEntity	epicanthal fold	A fold of skin of the upper eyelid that partially covers the inner corner of the eye.	FMA:59370	hp.json	medial canthic fold|epicanthus|plica palpebronasalis|epicanthic fold|eye fold|palpebronasal fold	http://purl.obolibrary.org/obo/UBERON_0013766		pheno_slim
HP:0033577	biolink:PhenotypicFeature	In situ pulmonary artery thrombosis	Localized thrombosis in pulmonary arteries frequently found in patients with idiopathic and hereditary pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease.		hp.json		http://purl.obolibrary.org/obo/HP_0033577		
UBERON:0011104	biolink:AnatomicalEntity	epiphysis of fifth metacarpal bone	An epiphysis that is part of a metacarpal bone of digit 5.	FMA:86330	hp.json	fifth metacarpal bone epiphysis|metacarpal 5 epiphysis	http://purl.obolibrary.org/obo/UBERON_0011104		
HP:0033572	biolink:PhenotypicFeature	Anti-H1 antibody positivity	The presence of autoantibodies in the blood circulation that react against histone H1.		hp.json		http://purl.obolibrary.org/obo/HP_0033572		
UBERON:0013760	biolink:AnatomicalEntity	external cervical os	Opening of uterine cervix into the vagina.	NCIT:C32491|FMA:76836|UMLS:C1512165	hp.json	ostium of uterus|ostium uteri|external os of uterus|external os	http://purl.obolibrary.org/obo/UBERON_0013760		
HP:0033571	biolink:PhenotypicFeature	Peripheral lung neovascularity	The presence of small, tortuous, micronodular, serpiginous intrapulmonary vessels often in the subpleural lung or in proximity to centrilobular arterioles, coursing in directions inconsistent with known arteriolar anatomy.		hp.json		http://purl.obolibrary.org/obo/HP_0033571		
CHEBI:24373	biolink:ChemicalSubstance	glycine derivative	A proteinogenic amino acid derivative resulting from reaction of glycine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.		hp.json		http://purl.obolibrary.org/obo/CHEBI_24373		3_STAR
UBERON:0013761	biolink:AnatomicalEntity	cervical cavity	The cavity formed by the walls of the cervix.	FMA:17746|BTO:0002249	hp.json	endocervical canal|endocervix|canal of the cervix|cervical canal|endocervical canal|cervical canal of uterus|lumen of cervix of uterus|endocervical|cavity of cervix	http://purl.obolibrary.org/obo/UBERON_0013761		human_reference_atlas
HP:0033574	biolink:PhenotypicFeature	Anti-H3 antibody positivity	The presence of autoantibodies in the blood circulation that react against histone H3.		hp.json		http://purl.obolibrary.org/obo/HP_0033574		
HP:0033573	biolink:PhenotypicFeature	Anti-H4 antibody positivity	The presence of autoantibodies in the blood circulation that react against histone H4.		hp.json		http://purl.obolibrary.org/obo/HP_0033573		
CHEBI:36357	biolink:ChemicalSubstance	polyatomic entity	Any molecular entity consisting of more than one atom.		hp.json	polyatomic entities	http://purl.obolibrary.org/obo/CHEBI_36357		3_STAR
CHEBI:36358	biolink:ChemicalSubstance	polyatomic ion	An ion consisting of more than one atom.		hp.json	polyatomic ions	http://purl.obolibrary.org/obo/CHEBI_36358		3_STAR
UBERON:0013756	biolink:AnatomicalEntity	venous blood	A blood that is part of a vein.	FMA:83067	hp.json	blood in vein|venous blood|portion of venous blood	http://purl.obolibrary.org/obo/UBERON_0013756		
UBERON:0013757	biolink:AnatomicalEntity	capillary blood	A blood that is part of a capillary.	FMA:263901|NCIT:C32212	hp.json	blood in capillary|portion of capillary blood|portion of blood in capillary	http://purl.obolibrary.org/obo/UBERON_0013757		
HP:0033579	biolink:PhenotypicFeature	Decreased growth hormone responses to growth hormone-releasing hormone challenge	Insufficient growth hormone secretion following administration of growth hormone-releasing hormone.		hp.json	Impaired growth hormone secretory responses after growth hormone-releasing hormone challenge	http://purl.obolibrary.org/obo/HP_0033579		
CHEBI:36359	biolink:ChemicalSubstance	phosphorus oxoacid derivative			hp.json	phosphorus oxoacid derivative	http://purl.obolibrary.org/obo/CHEBI_36359		3_STAR
UBERON:0013758	biolink:AnatomicalEntity	cervical os	One of two openings in the uterine cervix.	FMA:20422	hp.json	uterine cervix opening|cervical opening	http://purl.obolibrary.org/obo/UBERON_0013758		
UBERON:0001785	biolink:AnatomicalEntity	cranial nerve	Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord.	SCTID:244447006|UMLS:C1269897|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1227|GAID:802|VHOG:0000279|BIRNLEX:1623|FMA:5865|BAMS:cran|OpenCyc:Mx4rvWvJVpwpEbGdrcN5Y29ycA|Wikipedia:Cranial_nerve|MA:0000215|MESH:D003391|ZFA:0000641|AAO:0000108|UMLS:C0010268|NCIT:C12700|HBA:9299|MBA:967|TAO:0000641|EHDAA2:0000323|XAO:0003089|EMAPA:17264|UMLS:C0010268|BTO:0001104|XAO:0000429	hp.json	cranial neural tree organ|nervus cranialis|nervus cranialis|cranial nerves	http://purl.obolibrary.org/obo/UBERON_0001785		human_reference_atlas|uberon_slim|vertebrate_core|pheno_slim
UBERON:0001787	biolink:AnatomicalEntity	photoreceptor layer of retina	The layer within the retina where the photoreceptor cell receptor segments reside.	MA:0001308|EMAPA:35686|NCIT:C32954|XAO:0003215|VHOG:0001165|UMLS:C0229206|ZFA:0000143|FMA:58680|TAO:0000143	hp.json	layer of rods and cones|stratum segmentorum externorum et internorum (retina)|retinal photoreceptor layer|stratum segmentorum externorum et internorum retinae|retina photoreceptor layer|retinal photoreceptor layers	http://purl.obolibrary.org/obo/UBERON_0001787		pheno_slim|uberon_slim|vertebrate_core
UBERON:0001786	biolink:AnatomicalEntity	fovea centralis	A depression in the inner retinal surface within the macula lutea, the photoreceptor layer of which is entirely cones and which is specialized for maximum visual acuity.	FMA:58658|UMLS:C0016622|EV:0100350|NCIT:C26463|MESH:D005584|MA:0001307|UMLS:C0450290|GAID:910|BIRNLEX:2543|VHOG:0001572|CALOHA:TS-2055|UMLS:C0016622|EMAPA:37589	hp.json	centre of fovea|centre of macula|fovea centralis in macula|fovea	http://purl.obolibrary.org/obo/UBERON_0001786		uberon_slim|pheno_slim
UBERON:0001781	biolink:AnatomicalEntity	layer of retina	Any of the layers that make up the retina[MP].	MA:0001319|EMAPA:35742|XAO:0000266|SCTID:280657006|NCIT:C49328|UMLS:C0459649|FMA:58617|AAO:0010353	hp.json	retinal layer|retina neuronal layer|retina layer|retinal neuronal layer	http://purl.obolibrary.org/obo/UBERON_0001781		vertebrate_core|pheno_slim
UBERON:0001780	biolink:AnatomicalEntity	spinal nerve	The any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified].	BTO:0000870|OpenCyc:Mx4rwK_iFJwpEbGdrcN5Y29ycA|GAID:841|UMLS:C0037941|EHDAA2:0001898|SCTID:361099009|MA:0000233|XAO:0003101|Wikipedia:Spinal_nerve|MESH:D013127|VHOG:0000824|BAMS:spin|AAO:0011101|FMA:5858|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1228|NCIT:C12792|EMAPA:16989	hp.json	spinal column nerve|vertebral column nerve|nerve of spine|nervi spinales|nerve of backbone|spine nerve|spinal nerves|nerve of vertebral column|nervi spinales|nerve of spinal column|spinal nerve tree|backbone nerve	http://purl.obolibrary.org/obo/UBERON_0001780		uberon_slim|pheno_slim|human_reference_atlas
UBERON:0001783	biolink:AnatomicalEntity	optic disc	The optic disc or optic nerve head is the location where ganglion cell axons exit the eye to form the optic nerve. There are no light sensitive rods or cones to respond to a light stimulus at this point. This causes a break in the visual field called 'the blind spot' or the 'physiological blind spot'. The optic nerve head in a normal human eye carries from 1 to 1.2 million neurons from the eye towards the brain. [WP,unvetted].	MESH:D009898|FMA:58634|VHOG:0000551|EMAPA:18238|EHDAA:9077|EHDAA2:0001307|MA:0000278|UMLS:C0029127|CALOHA:TS-2153|EFO:0001974|NCIT:C12760	hp.json	optic nerve disc|optic nerve head|physiologic blind spot|optic disk|optic papilla|physiologic blind spot of mariotte|optic disk	http://purl.obolibrary.org/obo/UBERON_0001783		efo_slim|uberon_slim|pheno_slim
UBERON:0001782	biolink:AnatomicalEntity	pigmented layer of retina	A monolayer of pigmented epithelium covering the neural retina; develops from the outer of the two layers of the optic cup[ZFA]. the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells[WP].	NCIT:C33470|MA:0003173|BTO:0001177|AAO:0011096|XAO:0003217|MA:0000279|UMLS:C0035322|ZFA:0000144|EHDAA:4765|EMAPA:35738|TAO:0000144|CALOHA:TS-0869|EHDAA2:0001465|VHOG:0000536|FMA:58627|EMAPA:17172	hp.json	retinal pigment epithelium|retinal pigment layer|RPE|retinal pigmented epithelium|stratum pigmentosum (retina)|pigment epithelium of retina|PRE|stratum pigmentosum retinae|pigmented retinal epithelium|stratum pigmentosa retinae|pigmented retina|outer pigmented layer of retina|epithelium, retinal pigment|p. pigmentosa retinae|pigmented epithelium|pigmented retina epithelium	http://purl.obolibrary.org/obo/UBERON_0001782		human_reference_atlas|uberon_slim|vertebrate_core|pheno_slim
HP:0033581	biolink:PhenotypicFeature	Absent peripheral lymph nodes in presence of infection	The absence of any palpable lymph nodes in the presence of symptoms suggesting infection in that drainage area should raise suspicion for immunodeficiency diseases.		hp.json		http://purl.obolibrary.org/obo/HP_0033581		
HP:0033580	biolink:PhenotypicFeature	Compound motor action potential abnormality	An abnormal finding in a compound motor action potential measurement in EMG. Nerve conduction studies involve the application of a depolarising square wave electrical pulses to the skin over a peripheral nerve producing: (1) a propagated nerve action potential (NAP) recorded at a distant point over the same nerve: and (2) a compound muscle action potential (CMAP) arising from the activation of muscle fibres in a target muscle supplied by the nerve. In both cases these may be recorded with surface or needle electrodes. The CMAP is a summated voltage response from the individual muscle fibre action potentials. The shortest latency of the CMAP is the time from stimulus artefact to onset of the response and is a biphasic response with an initial upward deflection followed by a smaller downward deflection. The CMAP amplitude is measured from baseline to negative peak (the neurophysiological convention is that negative voltage is demonstrated by an upward deflection) and measured in millivolts (mV).		hp.json		http://purl.obolibrary.org/obo/HP_0033580		
UBERON:0001766	biolink:AnatomicalEntity	anterior chamber of eyeball	The space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens.	EMAPA:18231|MA:0000262|GAID:889|UMLS:C0003151|VHOG:0001431|EHDAA:9033|MESH:D000867|EHDAA2:0000129|FMA:58078|BTO:0002084|SCTID:181160009|Wikipedia:Anterior_chamber_of_eyeball|NCIT:C12667	hp.json	camera anterior bulbi oculi|camera anterior bulbi oculi|eye anterior chamber|camera oculi anterior|anterior chamber|camera anterior bulbi|camera anterior|anterior chamber of eye	http://purl.obolibrary.org/obo/UBERON_0001766		pheno_slim
UBERON:0001769	biolink:AnatomicalEntity	iris	The adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye.	AAO:0010347|EV:0100345|XAO:0000185|CALOHA:TS-0491|GAID:917|OpenCyc:Mx4rvVjbppwpEbGdrcN5Y29ycA|MA:0000273|EMAPA:19154|BTO:0000653|EFO:0004245|MESH:D007498|VHOG:0000101|UMLS:C0022077|ZFA:0001238|FMA:58235|NCIT:C12737|SCTID:181164000|TAO:0001238|Wikipedia:Iris_(anatomy)	hp.json	irides|anterior uvea|irises	http://purl.obolibrary.org/obo/UBERON_0001769		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0001768	biolink:AnatomicalEntity	uvea	The pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited].	EMAPA:35901|GAID:912|SCTID:280648000|UMLS:C0042160|CALOHA:TS-2228|MA:0002480|FMA:58103|Wikipedia:Uvea|NCIT:C12811|MESH:D014602	hp.json	tunica vasculatis oculi|pars iridica retinae|pars iridica retinae|uveal tract|tunica vasculosa bulbi|tunica vasculosa of eyeball|tunica vasculatis oculi|vascular layer of eyeball|uvea|tunica vasculosa bulbi	http://purl.obolibrary.org/obo/UBERON_0001768		pheno_slim|uberon_slim
HP:0033587	biolink:PhenotypicFeature	Vulvar abscess	A circumscribed area of pus or necrotic debris in the vulvar region.		hp.json		http://purl.obolibrary.org/obo/HP_0033587		
UBERON:0013752	biolink:AnatomicalEntity	diaphysis of metacarpal bone	A diaphysis that is part of a metacarpal bone.	FMA:33804	hp.json	metacarpal bone diaphysis|shaft of metacarpal|corpus ossis metacarpi|body of metacarpal|shaft of metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0013752		
UBERON:0013753	biolink:AnatomicalEntity	distal epiphysis of metacarpal bone	A distal epiphysis that is part of a metacarpal bone.	FMA:33798	hp.json	caput ossis metacarpi|lower end of metacarpal bone|distal end of metacarpal bone|head of metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0013753		pheno_slim
HP:0033586	biolink:PhenotypicFeature	Cellular non-specific interstitial pneumonia	A type of non-specific interstitial pneumonia in which interstitial thickening is mainly due to infiltration of inflammatory cells and type II pneumocyte hyperplasia.		hp.json		http://purl.obolibrary.org/obo/HP_0033586		
HP:0033589	biolink:PhenotypicFeature	Flatulence	Passage of excessive amounts of gas and the feeling of abdominal fullness and bloating.		hp.json		http://purl.obolibrary.org/obo/HP_0033589		
UBERON:0035102	biolink:AnatomicalEntity	transverse process of caudal vertebra	A transverse process that is part of a caudal vertebra.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035102		
UBERON:0013754	biolink:AnatomicalEntity	integumentary system layer	An organ component layer that is part of a integumental system.	SCTID:314820002	hp.json	skin layer|layer of skin	http://purl.obolibrary.org/obo/UBERON_0013754		non_informative
UBERON:0013755	biolink:AnatomicalEntity	arterial blood	A blood that is part of a artery.	FMA:83066	hp.json	arterial blood|blood in artery|portion of arterial blood	http://purl.obolibrary.org/obo/UBERON_0013755		pheno_slim
HP:0033588	biolink:PhenotypicFeature	Labial adhesion	Synechia vulvae (adhesions of the labia minora) are characterized by a complete or partial fusion of the labia minora in the midline.		hp.json	Labial agglutination|Synechia vulvae	http://purl.obolibrary.org/obo/HP_0033588		
HP:0033583	biolink:PhenotypicFeature	Follicular bronchiolitis	Follicular bronchiolitis is a polyclonal hyperplasia of bronchiolar associated lymphoid tissue characterized by the is characterized by the development of lymphoid follicles with germinal centers in walls of the small airways.		hp.json		http://purl.obolibrary.org/obo/HP_0033583		
UBERON:0035104	biolink:AnatomicalEntity	raphe of penis		FMA:19646	hp.json	raphe penis|penile raphe	http://purl.obolibrary.org/obo/UBERON_0035104		
HP:0033582	biolink:PhenotypicFeature	Pulmonary interstitial lymphocyte infiltration	Abnormal accumulation of lymphocytes in the interstitium of the lung.		hp.json		http://purl.obolibrary.org/obo/HP_0033582		
UBERON:0013750	biolink:AnatomicalEntity	metaphysis of tibia	A metaphysis that is part of a tibia.	EMAPA:37772|FMA:33135|MA:0003106	hp.json	tibial metaphysis	http://purl.obolibrary.org/obo/UBERON_0013750		pheno_slim
UBERON:0035106	biolink:AnatomicalEntity	raphe of perineum	The perineal raphe extends from the anus, through the mid-line of the scrotum (scrotal raphe) and upwards through the posterior mid-line aspect of the penis (penile raphe).	FMA:20244	hp.json	raphe perinei|raphe perinealis|perineal raphe	http://purl.obolibrary.org/obo/UBERON_0035106		
HP:0033585	biolink:PhenotypicFeature	Fibrotic non-specific interstitial pneumonia	A type of non-specific interstitial pneumonia in which interstitial thickening is due to uniform dense or loose fibrosis and mild chronic inflammation.		hp.json		http://purl.obolibrary.org/obo/HP_0033585		
UBERON:0013751	biolink:AnatomicalEntity	metaphysis of radius	A metaphysis that is part of a radius bone.	FMA:33789	hp.json	radial metaphysis	http://purl.obolibrary.org/obo/UBERON_0013751		pheno_slim
HP:0033584	biolink:PhenotypicFeature	Nonspecific interstitial pneumonia	Temporally uniform (all lesions are in the same stage of evolution) pattern of diffuse inflammatory interstitial process, mostly symmetric over the entire lung, involving mainly the alveolar septa.		hp.json	Temporally uniform pulmonary inflammation|NSIP|Nonspecific interstitial pneumonitis	http://purl.obolibrary.org/obo/HP_0033584		
UBERON:0035105	biolink:AnatomicalEntity	sac of scrotum	Any of the two testis-carrying compartments of the scrotum.	FMA:18251	hp.json	testis comartment|scrotal sac|scrotal comartment	http://purl.obolibrary.org/obo/UBERON_0035105		
UBERON:0013749	biolink:AnatomicalEntity	metaphysis of humerus	A metaphysis that is part of a metaphysis.	FMA:32830	hp.json	humeral metaphysis|diaphyseal end of humerus	http://purl.obolibrary.org/obo/UBERON_0013749		pheno_slim
CHEBI:61336	biolink:ChemicalSubstance	C4-dicarboxylate	A dicarboxylate that contains four carbon atoms.		hp.json		http://purl.obolibrary.org/obo/CHEBI_61336		3_STAR
UBERON:0013748	biolink:AnatomicalEntity	ulnar metaphysis	A metaphysis that is part of a ulna.	FMA:33767	hp.json	metaphysis of ulna	http://purl.obolibrary.org/obo/UBERON_0013748		pheno_slim
UBERON:0001774	biolink:AnatomicalEntity	skeletal muscle of trunk	A skeletal muscle organ that is part of the trunk region.	XAO:0003230|TAO:0000473|EMAPA:35888|MA:0000514|FMA:58274|ZFA:0000473|AAO:0000611	hp.json	muscle organ of torso|muscle of trunk|torso muscle organ|trunk muscle organ|body musculature|trunk muscle|trunk musculature|muscle organ of trunk	http://purl.obolibrary.org/obo/UBERON_0001774		uberon_slim|vertebrate_core
UBERON:0001773	biolink:AnatomicalEntity	sclera	Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP].	SCTID:181163006|EV:0100342|MA:0000280|GAID:911|MESH:D012590|FMA:58269|VHOG:0001274|BTO:0001606|EMAPA:19027|OpenCyc:Mx4rv7yR55wpEbGdrcN5Y29ycA|UMLS:C0036410|Wikipedia:Sclera|NCIT:C12784|AAO:0010354|ZFA:0005563|XAO:0000183	hp.json	scleral capsule	http://purl.obolibrary.org/obo/UBERON_0001773		pheno_slim|uberon_slim|vertebrate_core
UBERON:0001776	biolink:AnatomicalEntity	optic choroid	Vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP].	NCIT:C12344|MA:0000263|EMAPA:19077|VHOG:0001568|UMLS:C0008520|GAID:913|SCTID:181172003|MESH:D002829|BTO:0001829|Wikipedia:Choroid|ZFA:0005229|FMA:58298|EV:0100347|TAO:0005229|CALOHA:TS-2054	hp.json	choroidea|choroid coat|chorioid|choroidea|choroidea|posterior uvea|choroidea|choroid coat|posterior uvea|eye choroid|optic choroid|choroid	http://purl.obolibrary.org/obo/UBERON_0001776		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0001775	biolink:AnatomicalEntity	ciliary body	The thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes.	EMAPA:19065|AAO:0010341|VHOG:0000102|MESH:D002924|BTO:0000260|Wikipedia:Ciliary_body|CALOHA:TS-0694|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1571|SCTID:263340007|FMA:58295|XAO:0000186|EV:0100346|NCIT:C12345|MA:0000264|UMLS:C0008779|GAID:916	hp.json	ciliary bodies|corpus ciliare|corpus ciliare|ocular ciliary body|corpus ciliare|anterior uvea|corpus ciliare	http://purl.obolibrary.org/obo/UBERON_0001775		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
HP:0008577	biolink:PhenotypicFeature	Underfolded helix	Underdevelopment of the helix that either affects the entire helix, or is localized.	UMLS:C1849735	hp.json	Poorly folded helices	http://purl.obolibrary.org/obo/HP_0008577		
HP:0008572	biolink:PhenotypicFeature	External ear malformation	A malformation of the auricle of the ear.	UMLS:C1846460	hp.json	External ear malformation	http://purl.obolibrary.org/obo/HP_0008572		
UBERON:0001772	biolink:AnatomicalEntity	corneal epithelium	The smooth stratified squamous epithelium that covers the outer surface of the cornea.	EMAPA:17162|TAO:0002187|NCIT:C12928|BTO:0000287|UMLS:C0459875|Wikipedia:Corneal_epithelium|EHDAA2:0000319|EFO:0001917|MESH:D019573|SCTID:368825001|GAID:895|FMA:58263|ZFA:0001683|CALOHA:TS-0173|MA:0001243	hp.json	epithelium anterius corneae|epithelium corneæ anterior layer|anterior corneal epithelium|epithelial tissue of cornea|cornea epithelium|epithelium of cornea|e. anterius corneae|endothelium corneale|epithelium anterius (cornea)|anterior endothelium of cornea|cornea epithelial tissue|epithelium posterius corneae|endothelium anterius corneae|external epithelium of cornea|e. anterius corneae|endothelium camerae anterioris bulbi	http://purl.obolibrary.org/obo/UBERON_0001772		human_reference_atlas|efo_slim|uberon_slim|vertebrate_core|pheno_slim
UBERON:0001771	biolink:AnatomicalEntity	pupil	The central circular aperture of the iris through which light rays enter the eye.	VHOG:0000116|AAO:0010351|MESH:D011680|TAO:0001283|MA:0001292|NCIT:C33429|OpenCyc:Mx4rvViBr5wpEbGdrcN5Y29ycA|UMLS:C0034121|FMA:58252|GAID:918|XAO:0000283|ZFA:0001283	hp.json	pupils	http://purl.obolibrary.org/obo/UBERON_0001771		uberon_slim|vertebrate_core|pheno_slim
HP:0008573	biolink:PhenotypicFeature	Low-frequency sensorineural hearing impairment	A form of sensorineural hearing impairment that affects primarily the lower frequencies.	UMLS:C3810445	hp.json	Low-frequency sensorineural hearing loss	http://purl.obolibrary.org/obo/HP_0008573		
HP:0033590	biolink:PhenotypicFeature	Inguinal abscess	A circumscribed area of pus or necrotic debris in the groin (inguinal region).		hp.json	Groin abscess	http://purl.obolibrary.org/obo/HP_0033590		
UBERON:0001759	biolink:AnatomicalEntity	vagus nerve	Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart).	ZFA:0000453|EFO:0002549|BIRNLEX:801|BAMS:Xn|UMLS:C0042276|VHOG:0000737|BAMS:10n|TAO:0000453|AAO:0010475|EMAPA:37797|MESH:D014630|XAO:0003097|Wikipedia:Vagus_nerve|HBA:9337|SCTID:362466001|UMLS:C0042276|MBA:917|GAID:721|MA:0001106|OpenCyc:Mx4rviHk2ZwpEbGdrcN5Y29ycA|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=702|FMA:5731|UMLS:C1305910|NCIT:C12812|galen:VagusNerve|BTO:0003472	hp.json	vagus X nerve|vagus nerve or its root|pneuomgastric nerve|nervus vagus|10n|vagal nerve|nervus vagus|nervus vagus [x]|vagus|vagus nerve tree|cranial nerve X|vagus nerve [X]|nerve X|tenth cranial nerve|CN-X|nervus vagus	http://purl.obolibrary.org/obo/UBERON_0001759		vertebrate_core|pheno_slim|human_reference_atlas|efo_slim|uberon_slim
HP:0033592	biolink:PhenotypicFeature	Anti-H3-H4 antibody positivity	The presence of autoantibodies in the blood circulation that react against the H3-H4 histone dimer.		hp.json		http://purl.obolibrary.org/obo/HP_0033592		
HP:0033591	biolink:PhenotypicFeature	Staghorn calculus	Large branching stones that fill part of all of the renal pelvis and renal calyces and they can be complete or partial depending on the level of occupancy of the collecting system.		hp.json	Staghorn renal stone	http://purl.obolibrary.org/obo/HP_0033591		
HP:0008591	biolink:PhenotypicFeature	Congenital conductive hearing impairment	A type of conductive deafness with congenital onset.	UMLS:C4021537	hp.json	Congenital conductive hearing loss|Congenital conductive deafness	http://purl.obolibrary.org/obo/HP_0008591		
UBERON:0001756	biolink:AnatomicalEntity	middle ear	The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)[GO].	EV:0100357|UMLS:C0013455|GAID:165|EMAPA:17000|MA:0000253|UMLS:C1268972|UMLS:C0013455|MAT:0000146|FMA:56513|MESH:D004432|NCIT:C12274|XAO:0000191|MIAA:0000146|AAO:0011065|EHDAA:5693|VHOG:0000312|OpenCyc:Mx4rvbw1j5wpEbGdrcN5Y29ycA|BTO:0002099|EHDAA2:0001181|BIRNLEX:1695|CALOHA:TS-2233	hp.json	auris media|auris media	http://purl.obolibrary.org/obo/UBERON_0001756		pheno_slim|uberon_slim
UBERON:0001758	biolink:AnatomicalEntity	periodontium	The tissues that invest or help to invest and support the teeth, including the periodontal ligament, gingivae, cementum, and alveolar and supporting bone[BTO].	CALOHA:TS-2380|MESH:D010519|UMLS:C0031093|GAID:216|BTO:0001021|NCIT:C33304	hp.json	periodontal ligament|tooth supporting structure|periodontal membrane|paradentium	http://purl.obolibrary.org/obo/UBERON_0001758		pheno_slim
UBERON:0001757	biolink:AnatomicalEntity	pinna	The part of the ear that projects from the head, connecting to the external acoustic meatus.	FMA:56580|UMLS:C0928075|EHDAA2:0001467|EV:0100355|OpenCyc:Mx4rvs_VC5wpEbGdrcN5Y29ycA|NCIT:C32165|galen:Auricle|EMAPA:17589|MA:0000259|VHOG:0000460	hp.json	auricle of ear|auricle of external ear|auricula (auris externa)|pinna of ear|auricula|auricle|pinnae	http://purl.obolibrary.org/obo/UBERON_0001757		pheno_slim|uberon_slim
HP:0033598	biolink:PhenotypicFeature	Fibrillar glomerular subepithelial deposits	Fibrillar deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relatively uniform increase in thickness (subjective estimate).		hp.json		http://purl.obolibrary.org/obo/HP_0033598		
UBERON:0035111	biolink:AnatomicalEntity	medial plantar nerve	A plantar nerve that supplies the medial side of the plantar part of the foot, including pedal digit 1.	FMA:44716	hp.json	nervus plantaris medialis|internal plantar nerve	http://purl.obolibrary.org/obo/UBERON_0035111		
UBERON:0035110	biolink:AnatomicalEntity	lateral plantar nerve	A plantar nerve that supplies the lateral side of the plantar part of the foot, including pedal digit 5.	FMA:44724	hp.json	nervus plantaris lateralis|external plantar nerve	http://purl.obolibrary.org/obo/UBERON_0035110		
HP:0033597	biolink:PhenotypicFeature	Decreased mucosal sucrase-isomaltase activity	Reduced activity of the linked disaccharidase, sucrase-isomaltase, which is a glycoprotein localized to the brush border membrane of small intestinal villi.		hp.json		http://purl.obolibrary.org/obo/HP_0033597		
HP:0033599	biolink:PhenotypicFeature	Glomerular amyloid subepithelial deposits	A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).		hp.json		http://purl.obolibrary.org/obo/HP_0033599		
UBERON:0035112	biolink:AnatomicalEntity	intrinsic muscle	Any of the muscles that are entirely within the body part or segment moved by them.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035112		grouping_class
HP:0033594	biolink:PhenotypicFeature	Elevated urinary 7-biopterin level	An abnormally increased amount of 7-biopterin in the urine.		hp.json	Primapterinuria	http://purl.obolibrary.org/obo/HP_0033594		
CHEBI:51958	biolink:ChemicalSubstance	organic polycyclic compound			hp.json	organic polycyclic compounds	http://purl.obolibrary.org/obo/CHEBI_51958		3_STAR
UBERON:0035115	biolink:AnatomicalEntity	diastema between central incisors	A space or gap between the left and right central incisors, on either the upper or lower jaw.		hp.json	midline diastema|interdental space, central incisors	http://purl.obolibrary.org/obo/UBERON_0035115		
HP:0033593	biolink:PhenotypicFeature	Anti-H2A-H2B antibody positivity	The presence of autoantibodies in the blood circulation that react against the H2A-H2B histone dimer.		hp.json		http://purl.obolibrary.org/obo/HP_0033593		
CHEBI:48300	biolink:ChemicalSubstance	D-threitol	The D-enantiomer of threitol.	KEGG:C16884|PMID:17577890|Gmelin:1782960|PMID:25108762|PMID:17979222|Beilstein:5725952|PDBeChem:DTL|PMID:24643482|HMDB:HMDB0004136|PMID:22735334|DrugBank:DB03278|Wikipedia:Threitol|PMID:6368527|PMID:5855592|MetaCyc:CPD-12825|PMID:18863753|PMID:1596913|CAS:2418-52-2|CAS:7493-90-5|PMID:16748290|PMID:908147|Reaxys:1719752|Beilstein:1719752|PMID:16901854	hp.json	D-threo-tetritol|(2R,3R)-butane-1,2,3,4-tetrol|D-threitol	http://purl.obolibrary.org/obo/CHEBI_48300		3_STAR
UBERON:0035117	biolink:AnatomicalEntity	diastema between lower central incisors	A space or gap between the left and right central incisors on the lower jaw.		hp.json	interdental space between mandibular central incisors|midline mandibular diastema|interdental space, lower central incisors	http://purl.obolibrary.org/obo/UBERON_0035117		
HP:0033596	biolink:PhenotypicFeature	Elevated urinary 3-methylcrotonylglycine level	An abnormally increased amount of 3-methylcrotonylglycine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033596		
HP:0033595	biolink:PhenotypicFeature	Elevated circulating globotriaosylceramide concentration	Increased concentration of globotriaosylceramide (Gb3) in the blood circulation. Globotriaosylceramide, also named ceramidetrihexoside, is the primary lipid storage in Fabry disease.		hp.json	Elevated circulating ceramidetrihexoside concentration	http://purl.obolibrary.org/obo/HP_0033595		
UBERON:0035116	biolink:AnatomicalEntity	diastema between upper central incisors	A space or gap between the left and right central incisors on the upper jaw.		hp.json	interdental space between maxillary central incisors|midline maxillary diastema|interdental space, upper central incisors	http://purl.obolibrary.org/obo/UBERON_0035116		
UBERON:0035109	biolink:AnatomicalEntity	plantar nerve	A nerve that innervates the sole of the foot. Planar nerves arise from the posterior branch of the tibial nerve.	NCIT:C77674	hp.json	nerve, plantar	http://purl.obolibrary.org/obo/UBERON_0035109		
CHEBI:36339	biolink:ChemicalSubstance	baryon	Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy).		hp.json	baryons	http://purl.obolibrary.org/obo/CHEBI_36339		3_STAR
CHEBI:36338	biolink:ChemicalSubstance	lepton	Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin).		hp.json	leptons	http://purl.obolibrary.org/obo/CHEBI_36338		3_STAR
HP:0008587	biolink:PhenotypicFeature	Mild neurosensory hearing impairment	The presence of a mild form of sensorineural hearing impairment.	UMLS:C4021538	hp.json	Mild neurosensory hearing loss	http://purl.obolibrary.org/obo/HP_0008587		
UBERON:0001763	biolink:AnatomicalEntity	odontogenic papilla	A condensation of odontoblasts that forms the part of a tooth germ that gives rise to dentin and pulp in the mature tooth. It lies below a cellular aggregation known as the enamel organ.	XAO:0004045|GAID:1277|MESH:D003771|VSAO:0000025|ZFA:0005140|VHOG:0001465|EMAPA:32892|FMA:57662|TAO:0005140|BTO:0001839|MA:0001598	hp.json	pharyngeal tooth mesenchyme|tooth mesenchyme|dental papilla|papilla dentis|dermal papilla|odontogenic condensation|dentinal papilla	http://purl.obolibrary.org/obo/UBERON_0001763		uberon_slim|vertebrate_core
HP:0008586	biolink:PhenotypicFeature	Hypoplasia of the cochlea	Developmental hypoplasia of the cochlea.	UMLS:C2676974	hp.json	Hypoplastic cochlea|Underdeveloped cochlea	http://purl.obolibrary.org/obo/HP_0008586		
UBERON:0001765	biolink:AnatomicalEntity	mammary duct	Epithelial tube that transports milk[GO].	BTO:0002845|MA:0000791|EMAPA:35538|UMLS:C0222613|FMA:58006|NCIT:C32910|CALOHA:TS-2385	hp.json	galactophorous duct|ductus lactiferi|mammary gland duct|lactiferous gland duct|lactiferous duct|lactiferous tubule|galactophorous tubule|mammilary duct|ductus lactiferi	http://purl.obolibrary.org/obo/UBERON_0001765		pheno_slim|uberon_slim
HP:0008589	biolink:PhenotypicFeature	Hypoplastic helices	Underdevelopment of the helix, i.e., of the outer rim of the pinna.	UMLS:C1842681	hp.json	Underdeveloped helices	http://purl.obolibrary.org/obo/HP_0008589		
HP:0008588	biolink:PhenotypicFeature	Slit-like opening of the exterior auditory meatus	A type of stenosis of the external auditory meatus in which the opening of the external auditory meatus appears as a vertical slit.	UMLS:C1846459	hp.json		http://purl.obolibrary.org/obo/HP_0008588		
UBERON:0001764	biolink:AnatomicalEntity	maxillary sinus	One of the paired paranasal sinuses, located in the body of the maxilla, communicating with the middle meatus of the nasal cavity.	FMA:57715|OpenCyc:Mx4rvp2ZWJwpEbGdrcN5Y29ycA|NCIT:C12275|MESH:D008443|GAID:358|UMLS:C0024957|CALOHA:TS-2231|MA:0001794	hp.json	sinus maxilliaris|antrum of Highmore|maxillary antrum|Highmore antrum	http://purl.obolibrary.org/obo/UBERON_0001764		pheno_slim|uberon_slim
HP:0008583	biolink:PhenotypicFeature	Underfolded superior helices	A condition in which the superior portion of the helix is folded over to a lesser degree than normal.	UMLS:C4024655	hp.json		http://purl.obolibrary.org/obo/HP_0008583		
UBERON:0001760	biolink:AnatomicalEntity	frontal sinus	The frontal sinus occupies the dorsal part of the skull medial to the orbit. It overlaps cranial and nasal cavities and is often referred to as the conchofrontal sinus.	NCIT:C12277|OpenCyc:Mx4rvqMUR5wpEbGdrcN5Y29ycA|FMA:57417|UMLS:C0016734|GAID:357|MESH:D005626|MA:0001793	hp.json	cavity of frontal bone|sinus frontales	http://purl.obolibrary.org/obo/UBERON_0001760		pheno_slim|uberon_slim
CHEBI:73336	biolink:ChemicalSubstance	vulnerary	A drug used in treating and healing of wounds.	Wikipedia:Wound_healing	hp.json	vulneraries|wound-healing agent|wound-healing drugs|wound-healing drug|wound-healing agents	http://purl.obolibrary.org/obo/CHEBI_73336		3_STAR
UBERON:0011151	biolink:AnatomicalEntity	jaw depressor muscle	A muscle whose action is to depress the lower jaw.	XAO:0004127|AAO:0010655|TAO:0000612	hp.json	geniohyoideus muscle|protractor hyoidei|protractor hyoideus|geniohyoideus|branchiomandibularis|coracomandibularis|geniothoracis|depressor gnathalis	http://purl.obolibrary.org/obo/UBERON_0011151		
CHEBI:26986	biolink:ChemicalSubstance	threonine	An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.	CAS:80-68-2|Beilstein:8204750|Wikipedia:Threonine|PMID:15221503|CAS:80-68-2|PMID:11379295|PMID:22264337	hp.json	threonine|Threonin	http://purl.obolibrary.org/obo/CHEBI_26986		3_STAR
HP:0033521	biolink:PhenotypicFeature	Nasal dryness	A lack of humidification of the nasal mucosa.		hp.json		http://purl.obolibrary.org/obo/HP_0033521		
HP:0033520	biolink:PhenotypicFeature	Paradoxical embolism	Paradoxical embolism describes the passage of a venous or right-sided cardiac thrombus into the arterial or systemic circulation. Comment: Paradoxical embolism occurs most commonly through an intracardiac defect at the atrial level, but can also be due to another type of right-to-left-shunt, as for example in pulmonary arteriovenous malformations. Paradoxical embolism may lead to serious complications as ischemic stroke.		hp.json		http://purl.obolibrary.org/obo/HP_0033520		
CHEBI:26981	biolink:ChemicalSubstance	threitol		PMID:20717558|Gmelin:82500|CAS:7493-90-5	hp.json	(R*,R*)-1,2,3,4-butanetetrol|rel-(2R,3R)-butane-1,2,3,4-tetrol|threo-tetritol	http://purl.obolibrary.org/obo/CHEBI_26981		3_STAR
HP:0033523	biolink:PhenotypicFeature	Abnormal sperm principal piece morphology	A structural anomaly of the part of the sperm flagellum that is distal to the sperm midpiece and mitochondrial sheath and which leads into the end piece.		hp.json		http://purl.obolibrary.org/obo/HP_0033523		
UBERON:0011152	biolink:AnatomicalEntity	dorsal hyoid arch skeleton		ZFA:0001401|TAO:0001401|XAO:0003178|AAO:0010371	hp.json	dorsal hyoid arch|dorsal visceral arch 2|dorsal pharyngeal arch 2 skeleton	http://purl.obolibrary.org/obo/UBERON_0011152		
CHEBI:36309	biolink:ChemicalSubstance	cyclic tetrapyrrole			hp.json	macrocyclic tetrapyrroles|macrocyclic tetrapyrrole|cyclic tetrapyrroles	http://purl.obolibrary.org/obo/CHEBI_36309		3_STAR
HP:0033522	biolink:PhenotypicFeature	Cerebral cavernous malformation	A cerebral cavernous malformation (also known as cavernoma, cavernous angioma, cavernous hemangioma) is a collection of structurally abnormal slow-flow capillaries predominantly in the central nervous system. These are multiple mulberry-like distended caverns of dilated thin-walled capillaries without the normal intervening brain parenchymal architecture. Often, individual cavernomas are surrounded by hemosiderin representing remote oozing due to the abnormal capillaries.		hp.json		http://purl.obolibrary.org/obo/HP_0033522		
UBERON:0011159	biolink:AnatomicalEntity	primary subdivision of cranial skeletal system			hp.json		http://purl.obolibrary.org/obo/UBERON_0011159		non_informative
UBERON:0011158	biolink:AnatomicalEntity	primary subdivision of skull	The skull can be divided into two: the neurocranium and the facial skeleton.	FMA:54964	hp.json	subdivision of skull|skull subdivision	http://purl.obolibrary.org/obo/UBERON_0011158		non_informative
UBERON:0011156	biolink:AnatomicalEntity	facial skeleton	Subdivision of skull that consists of the facial bones.	EHDAA:8361|Wikipedia:Facial_skeleton|EHDAA2:0002206|EMAPA:18022|MA:0000318|FMA:53673	hp.json	facial bone|facial skeleton|ossa faciei|ossa facialia|ossa faciei|ossa facialia|viscerocranium	http://purl.obolibrary.org/obo/UBERON_0011156		pheno_slim
HP:0033529	biolink:PhenotypicFeature	Abnormal cardiac index	Any deviation from the normal value of the cardiac index, defined as cardiac output divided by body surface area.		hp.json		http://purl.obolibrary.org/obo/HP_0033529		
HP:0033528	biolink:PhenotypicFeature	Abnormal cardiac output	A deviation from normal Cardiac output, which is defined as the amount of blood pumped by the heart minute and is the mechanism whereby blood flows around the body, especially providing blood flow to the brain and other vital organs.		hp.json		http://purl.obolibrary.org/obo/HP_0033528		
CHEBI:61355	biolink:ChemicalSubstance	3-hydroxy carboxylic acid	Any hydroxy carboxylic acid which contains a hydroxy group located beta- to the carboxylic acid group.		hp.json	beta-hydroxy carboxylic acids|beta-hydroxycarboxylic acid|3-hydroxy carboxylic acids|3-hydroxycarboxylic acid|3-hydroxycarboxylic acids|beta-hydroxycarboxylic acids|beta-hydroxy carboxylic acid	http://purl.obolibrary.org/obo/CHEBI_61355		3_STAR
CHEBI:36300	biolink:ChemicalSubstance	tricarboxylic acid dianion			hp.json	tricarboxylic acid dianions	http://purl.obolibrary.org/obo/CHEBI_36300		3_STAR
HP:0033525	biolink:PhenotypicFeature	Absent sperm axoneme central pair complex	Absense of the central pair of microtubules in the sperm axoneme, thereby forming a 9+0 pattern instead of the normal 9+2 pattern.		hp.json	Absent central pair complex (9+0 pattern)	http://purl.obolibrary.org/obo/HP_0033525		
HP:0033524	biolink:PhenotypicFeature	Abnormal sperm axoneme morphology	Abnormal structure of the sperm axonemal structure which consists of a ring of nine microtubular doublets and a central pair of microtubules, giving the classical 9+2 microtubular arrangement. The axoneme contains a central pair of microtubules (C1 and C2) that are connected by a bridge-like structure forming the central pair complex (CPC). Each of the nine outer doublets is composed of type A and B microtubules and connected by radial spokes to the CPC.		hp.json		http://purl.obolibrary.org/obo/HP_0033524		
HP:0033527	biolink:PhenotypicFeature	Decreased gonadotropin-stimulated testosterone-to-androstenedione ratio	A reduced amount of testosterone relative in androstenedione in the blood circulation following administration of hCG (Human Chorionic Gonadotropin).		hp.json	Decreased plasma testosterone-to-androstenedione ratio	http://purl.obolibrary.org/obo/HP_0033527		
HP:0033526	biolink:PhenotypicFeature	Limited ankle dorsiflexion	Reduced ability to move the foot up toward the shin.		hp.json	Tight heel cord|Heel cord tightness	http://purl.obolibrary.org/obo/HP_0033526		
CHEBI:24329	biolink:ChemicalSubstance	glutarate	A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of glutaric acid.		hp.json	glutaric acid anion|glutarate anion|glutarates	http://purl.obolibrary.org/obo/CHEBI_24329		3_STAR
UBERON:0011144	biolink:AnatomicalEntity	adductor muscle of hip		BTO:0000030|MA:0002267|EMAPA:19166	hp.json	adductor group (leg)|muscle of adductor group	http://purl.obolibrary.org/obo/UBERON_0011144		
CHEBI:61360	biolink:ChemicalSubstance	globoside	Any glycosphingolipid where the oligosaccharide component has an N-acetylgalactosaminyl residue at the non-reducing end.	Wikipedia:Globoside	hp.json	globosides	http://purl.obolibrary.org/obo/CHEBI_61360		3_STAR
HP:0033532	biolink:PhenotypicFeature	Decreased cardiac output	A decreased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat.		hp.json		http://purl.obolibrary.org/obo/HP_0033532		
UBERON:0011143	biolink:AnatomicalEntity	upper urinary tract	Subdivision of urinary system which consists of the kidney and the ureters.	galen:UpperUrinaryTract|FMA:45658|NCIT:C61107	hp.json		http://purl.obolibrary.org/obo/UBERON_0011143		pheno_slim
HP:0033531	biolink:PhenotypicFeature	Decreased cardiac index	A reduced cardiac index, defined as cardiac output divided by body surface area.		hp.json		http://purl.obolibrary.org/obo/HP_0033531		
UBERON:0011142	biolink:AnatomicalEntity	axial ossicle	Ossicle that is part of the axial skeleton.	VSAO:0000133	hp.json	ossicle of postcranial-axial skeleton|vertebral ossicle|ossicle of axial skeleton	http://purl.obolibrary.org/obo/UBERON_0011142		
HP:0033534	biolink:PhenotypicFeature	Increased circulating brain natriuretic peptide concentration	An increased concentration of brain natriuretic peptide in the blood circulation.		hp.json	Increased B-type natriuretic peptide|Increased ventricular natriuretic peptide|Elevated circulating BNP concentration	http://purl.obolibrary.org/obo/HP_0033534		
UBERON:0011141	biolink:AnatomicalEntity	appendicular ossicle	Ossicle that is part of the appendicular skeleton.	VSAO:0000131|XAO:0004194	hp.json	ossicle of appendicular skeleton	http://purl.obolibrary.org/obo/UBERON_0011141		
HP:0033533	biolink:PhenotypicFeature	Increased cardiac output	An increased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat.		hp.json		http://purl.obolibrary.org/obo/HP_0033533		
UBERON:0011148	biolink:AnatomicalEntity	submucosal gland	Gland of the lamina epithelialis mucosae which perforate the lamina muscularis, with their adenomeres located in the submucosal connective tissue.	BTO:0003751|Wikipedia:Submucosal_glands|EMAPA:37970	hp.json		http://purl.obolibrary.org/obo/UBERON_0011148		
HP:0033530	biolink:PhenotypicFeature	Increased cardiac index	An elevated cardiac index, defined as cardiac output divided by body surface area.		hp.json		http://purl.obolibrary.org/obo/HP_0033530		
UBERON:0011145	biolink:AnatomicalEntity	adductor muscle	A muscle capable of adduction. Adduction is a movement which brings a part of the anatomy closer to the middle sagittal plane of the body. It is opposed to abduction.	FMA:74998|TAO:0002136|ZFA:0005268	hp.json	adductor	http://purl.obolibrary.org/obo/UBERON_0011145		functional_classification
CL:1001611	biolink:Cell	cerebellar neuron	Neuron of the cerebellum.	FMA:84665|CALOHA:TS-2359	hp.json	cerebellum neuron	http://purl.obolibrary.org/obo/CL_1001611		
CHEBI:38976	biolink:ChemicalSubstance	alkylbenzene	A  monocyclic arene that is benzene substituted with one or more alkyl groups.		hp.json	alkylbenzenes|alkylbenzene|Alkylbenzol	http://purl.obolibrary.org/obo/CHEBI_38976		3_STAR
CL:1001610	biolink:Cell	bone marrow hematopoietic cell	Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes.	CALOHA:TS-2109	hp.json	bone marrow hematopoietic cells|bone marrow poietic cells	http://purl.obolibrary.org/obo/CL_1001610		
HP:0033539	biolink:PhenotypicFeature	Bilateral apical pulmonary fibrosis	A reticular pattern of linear or lineonodular densities in apical portions of both the right and left lungs seen initially on high-resolution computed tomography and in case of progression also on standard chest x-ray.		hp.json		http://purl.obolibrary.org/obo/HP_0033539		
CHEBI:38975	biolink:ChemicalSubstance	methylbenzene	Any alkylbenzene that is benzene substituted with one or more methyl groups.		hp.json	methylbenzenes	http://purl.obolibrary.org/obo/CHEBI_38975		3_STAR
UBERON:0011139	biolink:AnatomicalEntity	synovial limb joint	Any synovial joint that is part of a (free) limb.	FMA:258776	hp.json	synovial joint of free limb segment	http://purl.obolibrary.org/obo/UBERON_0011139		
UBERON:0011138	biolink:AnatomicalEntity	postcranial axial skeletal system	Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.	FMA:302077	hp.json	axial skeletal system|post-cranial axial skeletal system|axial skeletal system	http://purl.obolibrary.org/obo/UBERON_0011138		
GO:0120262	biolink:BiologicalProcess	negative regulation of heterochromatin organization	Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin organization.		hp.json	down regulation of heterochromatin organization|inhibition of heterochromatin organization|down-regulation of heterochromatin organization|downregulation of heterochromatin organization	http://purl.obolibrary.org/obo/GO_0120262		
HP:0033536	biolink:PhenotypicFeature	Reduced platelet alpha granules	A reduced number of platelet alpha granules.		hp.json		http://purl.obolibrary.org/obo/HP_0033536		
HP:0033535	biolink:PhenotypicFeature	Reduced platelet dense granules	Decreased number of platelet dense granules, a type of platelet organelle.		hp.json		http://purl.obolibrary.org/obo/HP_0033535		
GO:0120263	biolink:BiologicalProcess	positive regulation of heterochromatin organization	Any process that activates or increases the frequency, rate or extent of heterochromatin organization.		hp.json	upregulation of heterochromatin organization|up regulation of heterochromatin organization|stimulation of heterochromatin organization|up-regulation of heterochromatin organization|activation of heterochromatin organization	http://purl.obolibrary.org/obo/GO_0120263		
HP:0033538	biolink:PhenotypicFeature	Aortic annulus calcification	Pathological deposition of calcium salts in the aortic annulus, a fibrous ring-like structure found at the insertion point of the basal attachments of the aortic valve leaflets within the left ventricular outflow tract.		hp.json	Aortic annular calcification	http://purl.obolibrary.org/obo/HP_0033538		
PR:000001753	biolink:Protein	transcription factor NF-kappa-B subunit	A protein with a core domain composition consisting of a Rel homology domain (RHD) (Pfam:PF00554), an IPT/TIG domain (Pfam:PF01833), six copies of the Ankyrin repeat (Pfam:PF00023), a Death domain (Pfam:PF00531) and a C-terminal PEST region.	PIRSF:PIRSF036310	hp.json	transcription factor NF-kappa-B	http://purl.obolibrary.org/obo/PR_000001753		
HP:0033537	biolink:PhenotypicFeature	Mosaic pulmonary attenuation pattern	Mosaic attenuation refers to heterogeneous areas of differing pulmonary attenuation on CT imaging.		hp.json		http://purl.obolibrary.org/obo/HP_0033537		
GO:0120261	biolink:BiologicalProcess	regulation of heterochromatin organization	Any process that modulates the frequency, rate, extent or location of heterochromatin organization.		hp.json		http://purl.obolibrary.org/obo/GO_0120261		
HP:0033543	biolink:PhenotypicFeature	Nicotine addiction	Nicotine addition can be defined as chronic compulsive nicotine seeking and continued use despite harmful consequences.		hp.json	Nicotine dependence	http://purl.obolibrary.org/obo/HP_0033543		
UBERON:0011133	biolink:AnatomicalEntity	intermetatarsal joint	A joint that connects two adjacent metatarsals.	FMA:35219	hp.json		http://purl.obolibrary.org/obo/UBERON_0011133		
UBERON:0011132	biolink:AnatomicalEntity	intercarpal joint	A skeletal joint that connects two carpal bones.	UMLS:C1262468|FMA:35292|NCIT:C32264	hp.json	intercarpal|midcarpal articulation|carpal joint|intercarpal articulation	http://purl.obolibrary.org/obo/UBERON_0011132		
HP:0033542	biolink:PhenotypicFeature	Bronchial wall thickening	Radiological appearance of increased density around the walls of a bronchus or large bronchiole. This feature is thought to be related to edema involving the bronchial wall as well as the peribronchial interstitial space. If the cross section of a bronchus is captured in a radiograph or computed tomography image, it is said to have the appearance of a donut because of the central lucency representing the airway of the bronchus surrounded by a circular region of increased density.		hp.json	Peribronchial thickening|Peribronchial cuffing	http://purl.obolibrary.org/obo/HP_0033542		
UBERON:0011131	biolink:AnatomicalEntity	intermetacarpal joint	A skeletal joint that connects two adjacent metacarpals[FMA,modified].	FMA:35288	hp.json	intermetacarpal articulation|intermetacarpal	http://purl.obolibrary.org/obo/UBERON_0011131		
HP:0033545	biolink:PhenotypicFeature	Mesangial fibrillary deposits	Extracellular mesangial aggregates composed of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material.		hp.json		http://purl.obolibrary.org/obo/HP_0033545		
HP:0033544	biolink:PhenotypicFeature	Mesangial fibril deposition	Extracellular mesangial accumulation of slender proteinaceous fibers.		hp.json		http://purl.obolibrary.org/obo/HP_0033544		
UBERON:0011130	biolink:AnatomicalEntity	temporomandibular joint primordium		EMAPA:18714	hp.json	temporo-mandibular joint primordium	http://purl.obolibrary.org/obo/UBERON_0011130		
UBERON:0011137	biolink:AnatomicalEntity	axial skeletal system	Subdivision of the skeletal system which consists of the axial skeleton plus associated joints.	FMA:7483	hp.json		http://purl.obolibrary.org/obo/UBERON_0011137		
UBERON:0011136	biolink:AnatomicalEntity	ligament of vertebral column	Ligament that joins successive centra. Important in controlling the stiffness of the vertebral column when it flexes.	FMA:31892	hp.json	vertebral column ligament|vertebral centrum ligament|intervertebral ligament	http://purl.obolibrary.org/obo/UBERON_0011136		
HP:0033541	biolink:PhenotypicFeature	Irreversible airflow obstruction	Airflow obstruction without significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL.		hp.json	Irreversible pulmonary obstruction	http://purl.obolibrary.org/obo/HP_0033541		
UBERON:0011135	biolink:AnatomicalEntity	intervertebral cartilage	A cartilage element that lies between two successive vertebral centra.	AAO:0000795	hp.json		http://purl.obolibrary.org/obo/UBERON_0011135		
UBERON:0011134	biolink:AnatomicalEntity	nonsynovial joint	Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis.	FMA:7491	hp.json	solid joint	http://purl.obolibrary.org/obo/UBERON_0011134		
HP:0033540	biolink:PhenotypicFeature	Reversible airflow obstruction	Airflow obstruction with a significant response to a bronchodilator defined as an increase in FEV1 and/or FVC by 12 percent or more and by at least 200 mL.		hp.json	Reversible pulmonary obstruction	http://purl.obolibrary.org/obo/HP_0033540		
GO:0120277	biolink:BiologicalProcess	positive regulation of cerebral blood circulation	Any process that activates or increases the frequency, rate or extent of cerebral blood circulation.		hp.json	up regulation of cerebral blood circulation|positive regulation of cerebrum blood circulation|up-regulation of cerebral blood circulation|activation of cerebral blood circulation|positive regulation of telencephalon blood circulation|upregulation of cerebral blood circulation	http://purl.obolibrary.org/obo/GO_0120277		
GO:0120278	biolink:BiologicalProcess	negative regulation of cerebral blood circulation	Any process that stops, prevents or reduces the frequency, rate or extent of cerebral blood circulation.		hp.json	negative regulation of cerebrum blood circulation|negative regulation of telencephalon blood circulation|downregulation of cerebral blood circulation|down regulation of cerebral blood circulation|inhibition of cerebral blood circulation|down-regulation of cerebral blood circulation	http://purl.obolibrary.org/obo/GO_0120278		
HP:0033547	biolink:PhenotypicFeature	Mesangial immunotactoid deposits	Extracellular mesangial aggregates composed of non-branching fibrils, focally parralel over 30 nM in diameter. The term immunotactoid refers to highly organized immune depositions appearing as rod-like microtubular structures in ultrastructural examination.		hp.json		http://purl.obolibrary.org/obo/HP_0033547		
HP:0033546	biolink:PhenotypicFeature	Mesangial microfibril deposition	Unbranched noncollagenous microfibrils within the mesangial matrix, composed of proteins not present within the glomerular basement membrane (GBM), most notably fibrillin-1, that attach to mesangial cells and GBM structural proteins.		hp.json		http://purl.obolibrary.org/obo/HP_0033546		
HP:0033549	biolink:PhenotypicFeature	Nodular mesangiosclerosis	Lobular, round to oval mesangial lesions with an acellular hyaline/matrix core surrounded by compressed mesangial nuclei.		hp.json		http://purl.obolibrary.org/obo/HP_0033549		
GO:0120275	biolink:BiologicalProcess	cerebral blood circulation	The flow of blood through the network of arteries and veins supplying the cerebrum, enabling the transport of nutrients to the tissues and the removal of waste products.		hp.json	telencephelon blood circulation|cerebrum blood circulation	http://purl.obolibrary.org/obo/GO_0120275		
GO:0120276	biolink:BiologicalProcess	regulation of cerebral blood circulation	Any process that modulates the frequency, rate or extent of cerebral blood circulation.		hp.json	regulation of telencephalon blood circulation|regulation of cerebrum blood circulation	http://purl.obolibrary.org/obo/GO_0120276		
HP:0033548	biolink:PhenotypicFeature	Mesangial amyloid deposition	Extracellular mesangial aggregates composed of fine, randomly oriented, non-branching fibrils 8-12 nm in diameter, often forming a cottony mass.		hp.json		http://purl.obolibrary.org/obo/HP_0033548		
UBERON:0001799	biolink:AnatomicalEntity	vitreous chamber of eyeball	The chamber in the eyeball enclosing the vitreous humor, bounded anteriorly by the lens and ciliary body and posteriorly by the posterior wall of the eyeball[BTO,modified].	BTO:0002087|EMAPA:37805|UMLS:C0229095|NCIT:C33885|FMA:58848|MA:0002461	hp.json	camera postrema bulbi oculi|camera vitrea bulbi|camera vitrea|vitreous chamber|camera postrema bulbi oculi|postremal chamber of eyeball|postremal chamber|camera postrema	http://purl.obolibrary.org/obo/UBERON_0001799		uberon_slim
CHEBI:24315	biolink:ChemicalSubstance	glutamic acid derivative	An amino acid derivative resulting from reaction of glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing glutamic acid residues.		hp.json		http://purl.obolibrary.org/obo/CHEBI_24315		3_STAR
UBERON:0011122	biolink:AnatomicalEntity	cricoarytenoid joint	The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the arytenoid cartilage.	FMA:55102|UMLS:C0225555|NCIT:C32397	hp.json	crico-arytenoid joint|cricoarytenoid articulation|crico-arytenoid joint	http://purl.obolibrary.org/obo/UBERON_0011122		
HP:0033554	biolink:PhenotypicFeature	Anti-Mi2 antibody positivity	The presence of autoantibodies in the blood circulation that react against the Mi-2 antigen.		hp.json		http://purl.obolibrary.org/obo/HP_0033554		
UBERON:0011121	biolink:AnatomicalEntity	cricothyroid joint	The cricoarytenoid articulation (or joint) is a joint connecting the cricoid cartilage and the thyroid cartilage.	FMA:55101|UMLS:C0225540|NCIT:C32402	hp.json	crico-thyroid joint|cricothyroid articulation	http://purl.obolibrary.org/obo/UBERON_0011121		
HP:0033553	biolink:PhenotypicFeature	Septic embolism	Embolization of intravascular thrombus containing microorganisms into the distant tissues via arterial system.		hp.json	Septic emboli	http://purl.obolibrary.org/obo/HP_0033553		
HP:0033556	biolink:PhenotypicFeature	Anti-nucleoporin 62 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against nucleoporin 62.		hp.json	Anti-p62 antibody positivity	http://purl.obolibrary.org/obo/HP_0033556		
UBERON:0011120	biolink:AnatomicalEntity	laryngeal joint	A skeletal joint that connects a laryngeal cartilage.	FMA:55100	hp.json	joint of larynx|laryngeal articulation	http://purl.obolibrary.org/obo/UBERON_0011120		
HP:0033555	biolink:PhenotypicFeature	Anti-Ro/SS-A antibody positivity	The presence of autoantibodies in the blood circulation that react against Ro/SSA autoantigens.		hp.json	Anti-Ro/SSA antibody positivity	http://purl.obolibrary.org/obo/HP_0033555		
HP:0033550	biolink:PhenotypicFeature	Necrotizing pulmonary granulomatosis	A granuloma that is associated with necrotic changes. Caseation necrosis is defined as a region in granulomas with eosinophilic, granular and cheese-like cellular debris with necrosis. The word caseous itself means pertaining or related to cheese, and comes from the Latin word caseus, meaning cheese.		hp.json	Caseating pulmonary granulomatosis	http://purl.obolibrary.org/obo/HP_0033550		
HP:0033552	biolink:PhenotypicFeature	Chronic villitis	Villitis of unknown etiology (synonymous with villitis of unknown aetiology) is a histologic diagnosis and, although it may have a variable distribution, evidence indicates that 3 parenchymal blocks will identify 62% of villitis, reaching an asymptote of 6 and 7 blocks identifying 85% of villitis. Villitis of unknown etiology by definition excludes those cases where an etiology is identified, such as viral or acute infections, and thus is preferred to the term nonspecific chronic villitis. It is usually lymphohistiocytic: although the presence of rare plasma cells does not exclude the diagnosis, thorough evaluation for an infectious etiology, such as cytomegalovirus, is required in a predominantly plasma cell villitis.		hp.json	Chronic villitis (non-infectious)|Villitis of unknown aetiology|Nonspecific chronic villitis|Villitis of unknown etiology	http://purl.obolibrary.org/obo/HP_0033552		
HP:0033551	biolink:PhenotypicFeature	Non-necrotizing pulmonary granulomatosis	A granuloma located in the lung that is not associated with necrotic changes.		hp.json	Non-caseating pulmonary granulomatosis	http://purl.obolibrary.org/obo/HP_0033551		
UBERON:0011119	biolink:AnatomicalEntity	carpometacarpal joint	The carpometacarpal joints (CMC) are joints in the wrist that articulates the distal row of carpal bones and the proximal bases of the metacarpal bones.	NCIT:C32265|MESH:D052737|UMLS:C0224620|FMA:35287	hp.json	carpometacarpal articulation|articulationes carpometacarpeæ|CMJ|carpometacarpal	http://purl.obolibrary.org/obo/UBERON_0011119		
UBERON:0011118	biolink:AnatomicalEntity	tarsometatarsal joint	The tarsometatarsal articulations are arthrodial joints in the pes.	FMA:35216	hp.json	cuboideometatarsal|tarsometatarsal articulation|tarsometatarsal|Lisfranc joint|tarso-metatarsal join|articulationes tarsometatarsales	http://purl.obolibrary.org/obo/UBERON_0011118		pheno_slim
CHEBI:38958	biolink:ChemicalSubstance	indole alkaloid	An alkaloid containing an indole skeleton.	Wikipedia:Indole_alkaloid|KEGG:C06073	hp.json	indole alkaloids|Indole alkaloid	http://purl.obolibrary.org/obo/CHEBI_38958		3_STAR
UBERON:0013778	biolink:AnatomicalEntity	skin of sole of pes	A zone of skin that is part of a skin of pes.	FMA:37849	hp.json	plantar skin of foot|skin of plantar part of foot|skin of sole of foot	http://purl.obolibrary.org/obo/UBERON_0013778		pheno_slim
HP:0033558	biolink:PhenotypicFeature	Anti-histone antibody positivity	The presence of autoantibodies in the blood circulation that react against histone antigens.		hp.json		http://purl.obolibrary.org/obo/HP_0033558		
HP:0033557	biolink:PhenotypicFeature	Anti-proteinase 3 antibody positivity	The presence of autoantibodies in the blood circulation that react against proteinase 3. Proteinase 3 (PR3) antigen is a 29-kD serine protease that exists as a protein triplet in human neutrophils		hp.json	Anti-PR3 antibody positivity	http://purl.obolibrary.org/obo/HP_0033557		
HP:0033559	biolink:PhenotypicFeature	Anti-myeloperoxidase antibody positivity	The presence of autoantibodies in the blood circulation that react against myeloperoxidase.		hp.json	Anti-MPO antibody positivity	http://purl.obolibrary.org/obo/HP_0033559		
CHEBI:24319	biolink:ChemicalSubstance	EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor	An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of glutamate--ammonia ligase (EC 6.3.1.2).	Wikipedia:Glutamine_synthetase	hp.json	glutamate--ammonia ligase inhibitor|L-glutamate:ammonia ligase (ADP-forming) inhibitors|EC 6.3.1.2 (glutamate--ammonia ligase) inhibitors|glutamate--ammonia ligase (EC 6.3.1.2) inhibitors|EC 6.3.1.2 inhibitor|EC 6.3.1.2 inhibitors|glutamate--ammonia ligase (EC 6.3.1.2) inhibitor|L-glutamate:ammonia ligase (ADP-forming) inhibitor|glutamate--ammonia ligase inhibitors|L-glutamine synthetase inhibitor|glutamine synthetase inhibitor|glutamylhydroxamic synthetase inhibitors|glutamine synthetase inhibitors|glutamylhydroxamic synthetase inhibitor|L-glutamine synthetase inhibitors	http://purl.obolibrary.org/obo/CHEBI_24319		3_STAR
CHEBI:24318	biolink:ChemicalSubstance	glutamine family amino acid	An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class.	PMID:20716061	hp.json	glutamine family amino acids	http://purl.obolibrary.org/obo/CHEBI_24318		3_STAR
UBERON:0001705	biolink:AnatomicalEntity	nail	A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP].	GAID:1320|galen:Nail|MA:0002703|BTO:0001719|OpenCyc:Mx4rvVjJv5wpEbGdrcN5Y29ycA|EFO:0000956|CALOHA:TS-2034|VHOG:0001361|MESH:D009262|EMAPA:35580|EV:0100159|UMLS:C0027342|MAT:0000158|NCIT:C33156|FMA:54326|MIAA:0000158	hp.json	claw|nail/claw|talon	http://purl.obolibrary.org/obo/UBERON_0001705		efo_slim|uberon_slim|pheno_slim
UBERON:0001707	biolink:AnatomicalEntity	nasal cavity	An anatomical cavity that is part of the olfactory apparatus. This includes the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present.	TAO:0000130|FMA:54378|EMAPA:17604|BTO:0002096|MESH:D009296|EHDAA2:0001226|VHOG:0000271|EHDAA:6801|NCIT:C12424|AAO:0000314|UMLS:C0027423|ZFA:0000130|GAID:350|MA:0000284	hp.json	cavity of olfactory apparatus|nasal conduit space|olfactory cavity|cavitas nasi|cavity of nose|cavum nasi|nasal pit|olfactory chamber cavity|nasal canal|olfactory pit|cavitas nasi|olfactory chamber|nasal fossa|cavitas nasalis	http://purl.obolibrary.org/obo/UBERON_0001707		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001706	biolink:AnatomicalEntity	nasal septum	The nasal septum separates the left and right airways in the nose, dividing the two nostrils. It is depressed by the Depressor septi nasi muscle. [WP,unvetted].	VHOG:0000017|OpenCyc:Mx4rv7e-k5wpEbGdrcN5Y29ycA|EHDAA:6809|FMA:54375|NCIT:C33160|MESH:D009300|UMLS:C0027432|GAID:115|AAO:0000559|AAO:0010135|EHDAA2:0001234|MA:0000285|EHDAA2:0004104|EMAPA:17608	hp.json	septum of the nose|septum mobile nasi|septum nasi|septal cartilage|septum nasi	http://purl.obolibrary.org/obo/UBERON_0001706		uberon_slim|pheno_slim
GO:0097355	biolink:BiologicalProcess	protein localization to heterochromatin	Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin.		hp.json	protein localisation to heterochromatin	http://purl.obolibrary.org/obo/GO_0097355		
UBERON:0001701	biolink:AnatomicalEntity	glossopharyngeal ganglion	The group of neuron cell bodies associated with the ninth cranial nerve.	EHDAA:2838|FMA:53471|SCTID:244451008|EMAPA:16795|ZFA:0001301|EHDAA2:0000710|TAO:0001301|MA:0001077|VHOG:0000702	hp.json	glossopharyngeal IX ganglion|ganglion of glosspharyngeal nerve|gIX|ganglion of glossopharyngeal nerve|petrosal ganglion	http://purl.obolibrary.org/obo/UBERON_0001701		vertebrate_core|pheno_slim
UBERON:0001700	biolink:AnatomicalEntity	geniculate ganglion	The group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve).	EHDAA2:0000491|UMLS:C0017406|EMAPA:17569|BAMS:GgVII|TAO:0001291|VHOG:0000707|NCIT:C12721|EHDAA:5567|EFO:0003669|EHDAA2:0004623|GAID:718|FMA:53414|EHDAA:6644|MA:0001076|MESH:D005830|ZFA:0001291	hp.json	ganglion geniculi|internal genu|geniculate ganglion|ganglion genicularum|gVII|genicular ganglion|facial ganglion|ganglion geniculi nervi facialis|facial VII ganglion|genicular ganglion|geniculate	http://purl.obolibrary.org/obo/UBERON_0001700		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0001703	biolink:AnatomicalEntity	neurocranium	Subdivision of skeletal system that surrounds and protects the brain. Includes the skull base, sensory capsules and the central part of the skull roof.	AAO:0010153|TAO:0001580|FMA:53672|MA:0000317|XAO:0003170|SCTID:361731002|Wikipedia:Neuroranium|EMAPA:17681|EHDAA2:0000243|ZFA:0001580	hp.json	brain pan|brain box|brain case|braincase|brain pan	http://purl.obolibrary.org/obo/UBERON_0001703		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001702	biolink:AnatomicalEntity	eyelash	Any of the hairs that grow at the edge of the upper or lower eyelid.	GAID:73|UMLS:C0015422|MA:0002702|MESH:D005140|NCIT:C32576|OpenCyc:Mx4rvVi41pwpEbGdrcN5Y29ycA|FMA:53669	hp.json	eyelid cilium|cilia|cilium|hair of eyelid|blepharis|eyelid cilia	http://purl.obolibrary.org/obo/UBERON_0001702		uberon_slim|pheno_slim
UBERON:0001709	biolink:AnatomicalEntity	upper jaw region	Subdivision of head that consists of the upper jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].	EMAPA:17924|EHDAA:8025|VHOG:0000454|EHDAA2:0004607|FMA:59399|ncithesaurus:Upper_Jaw|EHDAA2:0002118|AAO:0000620	hp.json	upper pharyngeal jaws|palatoquadrate arch|maxillary part of mouth|maxillary part of mouth proper|alveolodental arch of bimaxilla|dorsal mandibular arch|dorsal pharyngeal arch 1	http://purl.obolibrary.org/obo/UBERON_0001709		uberon_slim|vertebrate_core
UBERON:0001708	biolink:AnatomicalEntity	jaw skeleton	Subdivision of skeleton which includes upper and lower jaw skeletons.	MA:0001905|MESH:D007568|OpenCyc:Mx4rvVjjEZwpEbGdrcN5Y29ycA|UMLS:C0022359|EMAPA:35455|ZFA:0001227|FMA:54396|galen:Jaw|GAID:214|TAO:0001227|AAO:0000988|BTO:0001749|Wikipedia:Jaw|NCIT:C48821|SCTID:181811001	hp.json	pharyngeal arch 1 skeleton|visceral arch 1|anterior splanchnocranium|mandibular arch skeleton|jaws|jaw cartilage|jaw|oral jaw skeleton|mandibular arch	http://purl.obolibrary.org/obo/UBERON_0001708		uberon_slim|vertebrate_core|pheno_slim
GO:1901165	biolink:BiologicalProcess	positive regulation of trophoblast cell migration	Any process that activates or increases the frequency, rate or extent of trophoblast cell migration.		hp.json	up regulation of trophoblast cell migration|up-regulation of trophoblast cell migration|activation of trophoblast cell migration|upregulation of trophoblast cell migration	http://purl.obolibrary.org/obo/GO_1901165		
GO:1901166	biolink:BiologicalProcess	neural crest cell migration involved in autonomic nervous system development	Any neural crest cell migration that is involved in autonomic nervous system development.		hp.json		http://purl.obolibrary.org/obo/GO_1901166		
HP:0008518	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the vertebral column		UMLS:C4024659	hp.json	Absent/underdeveloped vertebral column|Absent/underdeveloped spine|Absent/small backbone|Absent/small vertebral column|Absent/small spine|Absent/underdeveloped backbone	http://purl.obolibrary.org/obo/HP_0008518		
HP:0008517	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the sacrum	Aplasia or developmental hypoplasia of the sacral bone.	UMLS:C4024660	hp.json	Absent/underdeveloped sacrum|Absent/small sacrum	http://purl.obolibrary.org/obo/HP_0008517		
HP:0008519	biolink:PhenotypicFeature	Abnormal coccyx morphology	Any structural abnormality of the coccyx.	UMLS:C4024658	hp.json	Abnormal tailbone|Abnormality of the coccyx	http://purl.obolibrary.org/obo/HP_0008519		
HP:0008513	biolink:PhenotypicFeature	Bilateral conductive hearing impairment	A bilateral type of conductive hearing impairment.	UMLS:C0452136|SNOMEDCT_US:194417009	hp.json	Bilateral conductive hearing loss|Bilateral conductive deafness	http://purl.obolibrary.org/obo/HP_0008513		
HP:0008516	biolink:PhenotypicFeature	Abnormality of the vertebral spinous processes		UMLS:C4024661	hp.json		http://purl.obolibrary.org/obo/HP_0008516		
HP:0008515	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the vertebrae		UMLS:C4024662	hp.json	Absent/small vertebrae|Absent/underdeveloped vertebrae	http://purl.obolibrary.org/obo/HP_0008515		
UBERON:0001710	biolink:AnatomicalEntity	lower jaw region	Subdivision of head that consists of the lower jaw skeletal elements plus associated soft tissue (skin, lips, muscle)[cjm].	EFO:0003660|Wikipedia:Lower_jaw|SCTID:362637005|ncithesaurus:Lower_Jaw|FMA:59398|EHDAA2:0001018|EMAPA:17906|EHDAA:7995|MESH:D008334|AAO:0000272|VHOG:0000453	hp.json	mandibular part of mouth|mandibular series|lower part of mouth	http://purl.obolibrary.org/obo/UBERON_0001710		uberon_slim|vertebrate_core|efo_slim
HP:0008511	biolink:PhenotypicFeature	Central posterior corneal opacity	Reduced transparency of the central posterior portion of the corneal stroma.	UMLS:C0423260|SNOMEDCT_US:246967007	hp.json		http://purl.obolibrary.org/obo/HP_0008511		
GO:0097367	biolink:MolecularActivity	carbohydrate derivative binding	Binding to a carbohydrate derivative.		hp.json		http://purl.obolibrary.org/obo/GO_0097367		goslim_mouse|goslim_agr
GO:0097360	biolink:BiologicalProcess	chorionic trophoblast cell proliferation	The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population.		hp.json		http://purl.obolibrary.org/obo/GO_0097360		
HP:0008529	biolink:PhenotypicFeature	Absence of acoustic reflex	Absence of the acoustic reflex, an involuntary contraction of the stapedius muscle that occurs in response to high-intensity sound stimuli.	UMLS:C1832834	hp.json	Absence of acoustic middle ear muscle reflexes|Absent middle ear reflexes	http://purl.obolibrary.org/obo/HP_0008529		
HP:0008528	biolink:PhenotypicFeature	Long hairs growing from helix of pinna		UMLS:C4024657|UMLS:C0222050|SNOMEDCT_US:27394002	hp.json	Long hairs growing from helix of ear|Ear hair	http://purl.obolibrary.org/obo/HP_0008528		
HP:0008527	biolink:PhenotypicFeature	Congenital sensorineural hearing impairment	A type of hearing impairment caused by an abnormal functionality of the cochlear nerve with congenital onset.	UMLS:C1865866|SNOMEDCT_US:700453005	hp.json	Congenital sensorineural hearing loss|Congenital neurosensory deafness|Congenital perceptive deafness|Congenital sensorineural deafness|Bilateral congenital sensorineural deafness|Hearing loss, congenital sensorineural	http://purl.obolibrary.org/obo/HP_0008527		
HP:0008523	biolink:PhenotypicFeature	Posterior helix pit	Permanent indentation on the posteromedial aspect of the helix that may be sharply or indistinctly delineated.	UMLS:C4021539	hp.json	Ear, posterior helical groove|Ear, posterior helical notch|Pits in posterior aspect of ear helices|Helix, posterior pit|Indentation in back of outer ear	http://purl.obolibrary.org/obo/HP_0008523		hposlim_core
CL:1001609	biolink:Cell	muscle fibroblast	Fibroblast from muscle organ.	CALOHA:TS-0643	hp.json		http://purl.obolibrary.org/obo/CL_1001609		
HP:0033501	biolink:PhenotypicFeature	Subepithelial glomerular basement membrane electron dense deposits	Prominent glomerular basement membrane (GBM) reflecting a diffuse and relativly uniform increase in thickness (subjective estimate) with exogenous material deposited between the outer (epithelial) aspect of the GBM and the visceral epithelial cell, with varying degrees of incorporation into the GBM.		hp.json		http://purl.obolibrary.org/obo/HP_0033501		
HP:0033500	biolink:PhenotypicFeature	Subendothelial glomerular basement membrane electron dense deposits	Electron dense deposits in the glomerular basement membrane (GBM) subendothelial space associated with a prominent GBM reflecting an increase in thickness. This feature can be associated with GBM remodeling along the endothelial aspect.		hp.json		http://purl.obolibrary.org/obo/HP_0033500		
CL:1001603	biolink:Cell	lung macrophage	Circulating macrophages and tissue macrophages (alveolar macrophages) of lung.	CALOHA:TS-0576	hp.json	lung macrophages	http://purl.obolibrary.org/obo/CL_1001603		
CL:1001602	biolink:Cell	cerebral cortex endothelial cell	Endothelial cells forming the walls of the capillaries within the cerebral cortex.	CALOHA:TS-2372	hp.json	cerebral cortex endothelial cells|endothelial cells of cerebral cortex	http://purl.obolibrary.org/obo/CL_1001602		
HP:0033507	biolink:PhenotypicFeature	Decreased esterified to free carnitine ratio	A reduced ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine.		hp.json		http://purl.obolibrary.org/obo/HP_0033507		
HP:0033506	biolink:PhenotypicFeature	Increased esterified to free carnitine ratio	An elevated ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine.		hp.json		http://purl.obolibrary.org/obo/HP_0033506		
HP:0033509	biolink:PhenotypicFeature	EBV encephalitis	Inflamation of the brain related to infection by Epstein-Barr virus.		hp.json	Epstein-Barr virus encephalitis	http://purl.obolibrary.org/obo/HP_0033509		
HP:0033508	biolink:PhenotypicFeature	EBV meningitis	Inflammation of the meninges related to infection by Epstein-Barr virus.		hp.json	Epstein-Barr virus meningitis	http://purl.obolibrary.org/obo/HP_0033508		
GO:1901192	biolink:BiologicalProcess	positive regulation of formation of translation initiation ternary complex	Any process that activates or increases the frequency, rate or extent of formation of translation initiation ternary complex.		hp.json	activation of translation initiation ternary complex assembly|up-regulation of formation of translation initiation ternary complex|up-regulation of translation initiation ternary complex assembly|up regulation of translation initiation ternary complex assembly|up regulation of formation of translation initiation ternary complex|positive regulation of translation initiation ternary complex assembly|activation of formation of translation initiation ternary complex|upregulation of formation of translation initiation ternary complex|upregulation of translation initiation ternary complex assembly	http://purl.obolibrary.org/obo/GO_1901192		
HP:0033503	biolink:PhenotypicFeature	Elevated CSF fumarate	An increased concentration of fumarate, an intermediate in the citric acid cycle, in the cebrebrospinal fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0033503		
HP:0033502	biolink:PhenotypicFeature	Abnormal esterified to free carnitine ratio	Any deviation from the normal ratio of acylcarnitine (i.e., esterified carnitine) to free carnitine.		hp.json		http://purl.obolibrary.org/obo/HP_0033502		
GO:1901190	biolink:BiologicalProcess	regulation of formation of translation initiation ternary complex	Any process that modulates the frequency, rate or extent of formation of translation initiation ternary complex.		hp.json	regulation of translation initiation ternary complex assembly	http://purl.obolibrary.org/obo/GO_1901190		
HP:0033505	biolink:PhenotypicFeature	Livedo reticularis	Livedo reticularis is characterized by the presence of a bluish purple, mottled or netlike pattern in unbroken circles on the skin. Exposure to cold environments usually intensifies the vascular pattern. Presumably, the condition results from slow or stagnant blood flow, vessel-wall pathology, and decreased oxygen tension.		hp.json		http://purl.obolibrary.org/obo/HP_0033505		
GO:1901191	biolink:BiologicalProcess	negative regulation of formation of translation initiation ternary complex	Any process that stops, prevents or reduces the frequency, rate or extent of formation of translation initiation ternary complex.		hp.json	down regulation of formation of translation initiation ternary complex|down regulation of translation initiation ternary complex assembly|inhibition of formation of translation initiation ternary complex|downregulation of translation initiation ternary complex assembly|downregulation of formation of translation initiation ternary complex|inhibition of translation initiation ternary complex assembly|down-regulation of formation of translation initiation ternary complex|negative regulation of translation initiation ternary complex assembly|down-regulation of translation initiation ternary complex assembly	http://purl.obolibrary.org/obo/GO_1901191		
HP:0033504	biolink:PhenotypicFeature	Elevated circulating fumarate concentration	An increased concentration of fumarate, an intermediate in the citric acid cycle, in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033504		
HP:0033510	biolink:PhenotypicFeature	Cutaneous horn	A cutaneous horn is a keratinized non-malignant protrusion on the surface of the skin. Diagnosis is established by biopsy of the horn and biopsy of the horn and the underlying skin.		hp.json	Cornu cutaneum	http://purl.obolibrary.org/obo/HP_0033510		
HP:0033512	biolink:PhenotypicFeature	Stimulant addiction	Addiction to a stimulant drug, defined as a drug that typically increases alertness, attention and energy while also elevating blood pressure, heart rate and breathing.		hp.json	Stimulant dependence	http://purl.obolibrary.org/obo/HP_0033512		
HP:0033511	biolink:PhenotypicFeature	Drug addiction	Chronic compulsive drug seeking and continued use despite harmful consequences.		hp.json		http://purl.obolibrary.org/obo/HP_0033511		
HP:0033518	biolink:PhenotypicFeature	Methylphenidate addiction	Addiction to methylphenidate.		hp.json	Methylphenidate dependence	http://purl.obolibrary.org/obo/HP_0033518		
HP:0008507	biolink:PhenotypicFeature	Static ophthalmoparesis		UMLS:C4024663	hp.json		http://purl.obolibrary.org/obo/HP_0008507		
HP:0033517	biolink:PhenotypicFeature	Heroin addiction	Addiction to heroin.		hp.json	Heroin dependence	http://purl.obolibrary.org/obo/HP_0033517		
HP:0008509	biolink:PhenotypicFeature	Aged leonine appearance		UMLS:C3550331	hp.json		http://purl.obolibrary.org/obo/HP_0008509		
HP:0033519	biolink:PhenotypicFeature	Methamphetamine addiction	Addiction to methamphetamine.		hp.json	Methamphetamine dependence	http://purl.obolibrary.org/obo/HP_0033519		
HP:0033514	biolink:PhenotypicFeature	Amphetamine addiction	Addiction to amphetamine or dextroamphetamine.		hp.json	Amphetamine dependence|Dextroamphetamine addiction|Dextroamphetamine dependence	http://purl.obolibrary.org/obo/HP_0033514		
HP:0033513	biolink:PhenotypicFeature	Cocaine addiction	Addiction to cocaine.		hp.json	Cocaine dependence	http://purl.obolibrary.org/obo/HP_0033513		
HP:0033516	biolink:PhenotypicFeature	Benzodiazepine addiction	Addiction to a benzodiazepine.		hp.json	Benzodiazepine dependence	http://purl.obolibrary.org/obo/HP_0033516		
HP:0008504	biolink:PhenotypicFeature	Moderate sensorineural hearing impairment	The presence of a moderate form of sensorineural hearing impairment.	UMLS:C4020798|UMLS:C4024664	hp.json	Moderate neural deafness	http://purl.obolibrary.org/obo/HP_0008504		
HP:0033515	biolink:PhenotypicFeature	Opioid addiction	Addiction to opioids.		hp.json	Opioid dependence	http://purl.obolibrary.org/obo/HP_0033515		
HP:0008501	biolink:PhenotypicFeature	Median cleft lip and palate	Cleft lip or palate affecting the midline region of the palate.	UMLS:C2750604	hp.json	Midline cleft lip/palate|Medial cleft lip and palate|Wide midline cleft lip/palate|Central cleft lip and palate	http://purl.obolibrary.org/obo/HP_0008501		
CHEBI:48379	biolink:ChemicalSubstance	isourea	A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		hp.json	isoureas|isoureas	http://purl.obolibrary.org/obo/CHEBI_48379		3_STAR
UBERON:0001749	biolink:AnatomicalEntity	parenchyma of parathyroid gland	A parenchyma that is part of a parathyroid gland [Automatically generated definition].	MA:0002677|FMA:55569|EMAPA:35664	hp.json	parathyroid gland parenchyma|parenchyma of parathyroid|parathyroid parenchyma	http://purl.obolibrary.org/obo/UBERON_0001749		
UBERON:0001748	biolink:AnatomicalEntity	capsule of parathyroid gland	The dense and irregular connective tissue capsule surrounding a parathyroid gland.	MA:0002676|NCIT:C33265|FMA:55566|EMAPA:35663|UMLS:C0927176	hp.json	parathyroid gland capsule	http://purl.obolibrary.org/obo/UBERON_0001748		pheno_slim
CHEBI:48378	biolink:ChemicalSubstance	carboximidic acid			hp.json	carboximidic acids|carboximidic acids|carboximidic acid	http://purl.obolibrary.org/obo/CHEBI_48378		3_STAR
UBERON:0001745	biolink:AnatomicalEntity	secondary nodular lymphoid tissue	A lymphoid follicle that contains a germinal center.	GAID:946|FMA:55224	hp.json	peripheral lymphoid tissue|secondary lymphoid nodule|secondary lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0001745		uberon_slim
UBERON:0001744	biolink:AnatomicalEntity	lymphoid tissue	Portion of connective tissue with various types of white blood cells enmeshed in it, most numerous being the lymphocytes[WP].	GAID:342|NCIT:C13049|BTO:0000753|UMLS:C0024296|galen:LymphoidTissue|MESH:D008221|FMA:55220|MA:0002436|CALOHA:TS-0584	hp.json	lymphocytic tissue|lymphatic tissue	http://purl.obolibrary.org/obo/UBERON_0001744		pheno_slim|uberon_slim
UBERON:0001747	biolink:AnatomicalEntity	parenchyma of thyroid gland	A parenchyma that is part of a thyroid follicle [Automatically generated definition].	MA:0000730|EMAPA:37769|FMA:55515|BTO:0004579	hp.json	thyroid follicle parenchyma|thyroid gland parenchyma|parenchyma glandulae thyroideae|parenchyma of thyroid|parenchyma of thyroid follicle|parenchyma of thyroid gland follicle|thyroid parenchyma|thyroid gland follicle parenchyma	http://purl.obolibrary.org/obo/UBERON_0001747		
UBERON:0001746	biolink:AnatomicalEntity	capsule of thyroid gland		MA:0002675|EMAPA:37767|UMLS:C0229575|FMA:55513|NCIT:C33781	hp.json	capsula fibrosa glandulae thyroideae|thyroid capsule|fibrous capsule of thyroid gland|thyroid gland capsule	http://purl.obolibrary.org/obo/UBERON_0001746		
CHEBI:48377	biolink:ChemicalSubstance	imidic acid	Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing =O by =NR; thus tautomers of amides. In organic chemistry an unspecified imidic acid is generally a carboximidic acid, RC(=NR)(OH).		hp.json	imino acids|imidic acid|imidic acids|imidic acids	http://purl.obolibrary.org/obo/CHEBI_48377		3_STAR
CHEBI:48376	biolink:ChemicalSubstance	carbamimidic acid		Beilstein:773698|CAS:4744-36-9	hp.json	carbamimidic acid|pseudourea|carbamimic acid|HO-C(=NH)-NH2|H2N-C(=NH)-OH|H2N-C(OH)=NH|Isoharnstoff|isourea|carbonamidimidic acid	http://purl.obolibrary.org/obo/CHEBI_48376		3_STAR
UBERON:0013727	biolink:AnatomicalEntity	notochordal fluid	Fluid contained within the notochordal canal.		hp.json	notochord fluid|portion of notochordal fluid	http://purl.obolibrary.org/obo/UBERON_0013727		
HP:0008559	biolink:PhenotypicFeature	Hypoplastic superior helix		UMLS:C1865305	hp.json	Underdeveloped superior helices	http://purl.obolibrary.org/obo/HP_0008559		
UBERON:0001752	biolink:AnatomicalEntity	enamel	A dentine-like hypermineralized substance that covers the tooth tip. Enamel's primary mineral is hydroxylapatite, which is a crystalline calcium phosphate. Unlike dentin and bone, enamel does not contain collagen. Instead, it has two unique classes of proteins called amelogenins and enamelins[WP].	BTO:0001844|MESH:D003743|XAO:0004198|UMLS:C0011350|EMAPA:35303|NCIT:C32505|VSAO:0000065|CALOHA:TS-1057|FMA:55629|MA:0002543	hp.json	enameloid|enamel tissue|tooth enamel|enamel of tooth	http://purl.obolibrary.org/obo/UBERON_0001752		pheno_slim|uberon_slim|vertebrate_core
HP:0008554	biolink:PhenotypicFeature	Cochlear malformation	The presence of a malformed cochlea.	UMLS:C1862050	hp.json		http://purl.obolibrary.org/obo/HP_0008554		
UBERON:0001751	biolink:AnatomicalEntity	dentine	Collagen-rich odontogenic tissue characteristic of teeth and tooth-like skeletal elements (e.g., odontodes); mature dentine is mineralized and develops from predentine tissue; often (but not always) tubular and acellular.	NCIT:C32453|EMAPA:35281|ZFA:0005143|VHOG:0001589|VSAO:0000069|XAO:0004051|TAO:0005143|UMLS:C0011429|BTO:0003453|GAID:1272|MESH:D003804|FMA:55628|MA:0002542	hp.json	predentin|dentin|dentine of tooth|dentin	http://purl.obolibrary.org/obo/UBERON_0001751		pheno_slim|uberon_slim|vertebrate_core
UBERON:0001754	biolink:AnatomicalEntity	dental pulp	The part in the center of a tooth made up of living soft tissue and cells called odontoblasts[WP].	CALOHA:TS-0195|UMLS:C0011399|NCIT:C32451|VHOG:0001469|MESH:D003782|FMA:55631|ZFA:0005141|TAO:0005141|GAID:1270|MA:0001599|EMAPA:35274|BTO:0000339	hp.json	dental pulp cell|pulp of tooth|tooth pulp	http://purl.obolibrary.org/obo/UBERON_0001754		pheno_slim|uberon_slim|vertebrate_core
HP:0008555	biolink:PhenotypicFeature	Absent vestibular function	Complete lack of functioning of the vestibular apparatus.	UMLS:C4024656	hp.json		http://purl.obolibrary.org/obo/HP_0008555		
UBERON:0001753	biolink:AnatomicalEntity	cementum	Odontoid tissue that is deposited by cementoblasts onto dentine tissue and functions to attach teeth, odontodes and other odontogenic derivatives to bone tissue and the integument.	MA:0002541|CALOHA:TS-2163|BTO:0002525|NCIT:C32276|XAO:0004196|FMA:55630|EMAPA:35203|MESH:D003739|UMLS:C0011343|VSAO:0000062	hp.json	cementum|cementum of tooth|bone of attachment|cement of tooth|cement	http://purl.obolibrary.org/obo/UBERON_0001753		pheno_slim
UBERON:0001750	biolink:AnatomicalEntity	lacrimal apparatus	A network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta.	UMLS:C0022903|MA:0000274|NCIT:C32905|MESH:D007765|GAID:901|EMAPA:35462|FMA:55605	hp.json	nasolacrimal system|apparatus lacrimalis|lacrymal system|lacrimal drainage system|nasolacrimal drainage system	http://purl.obolibrary.org/obo/UBERON_0001750		pheno_slim|uberon_slim
HP:0008551	biolink:PhenotypicFeature	Microtia	Underdevelopment of the external ear.	UMLS:C0152423|SNOMEDCT_US:35045004|MSH:D065817	hp.json	Hypoplastic pinna|Bilateral microtia|Small pinnae|Hypoplasia of the external ear|Underdeveloped ears|Hypoplastic ears|Small ears	http://purl.obolibrary.org/obo/HP_0008551		hposlim_core
UBERON:0001738	biolink:AnatomicalEntity	thyroid cartilage	The largest of the laryngeal cartilages.	VHOG:0001365|MESH:D013957|FMA:55099|EHDAA:9395|EMAPA:18698|MA:0001764|GAID:112|UMLS:C0040126|BTO:0003655|NCIT:C33780|EHDAA2:0002030	hp.json	laryngeal prominence|pomus adamus|cartilago thyroidea|pomus|cartilago thyroidea	http://purl.obolibrary.org/obo/UBERON_0001738		uberon_slim|pheno_slim
UBERON:0001737	biolink:AnatomicalEntity	larynx	A continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.	EFO:0000838|MA:0000414|SCTID:181212004|EHDAA2:0004063|UMLS:C0023078|FMA:55097|EMAPA:18333|BTO:0001208|EV:0100039|Wikipedia:Larynx|AAO:0000268|NCIT:C12420|MAT:0000187|galen:Larynx|MESH:D007830|GAID:108|OpenCyc:Mx4rvViOnZwpEbGdrcN5Y29ycA|VHOG:0001279|MIAA:0000187|CALOHA:TS-0532|XAO:0003081	hp.json		http://purl.obolibrary.org/obo/UBERON_0001737		uberon_slim|pheno_slim|efo_slim
UBERON:0001739	biolink:AnatomicalEntity	laryngeal cartilage	The cartilaginous structures that support the larynx.	NCIT:C12281|BTO:0003660|VHOG:0001550|UMLS:C0023050|MESH:D007817|EMAPA:18697|SCTID:263482005|FMA:55108|EHDAA:8157|GAID:107|MA:0001758	hp.json	cartilagines laryngeales|larynx cartilage|cartilage of larynx	http://purl.obolibrary.org/obo/UBERON_0001739		pheno_slim
UBERON:0001734	biolink:AnatomicalEntity	palatine uvula	Conic projection from the posterior edge of the middle of the soft palate, composed of connective tissue containing a number of racemose glands, and some muscular fibers.	BTO:0002204|NCIT:C12232|EFO:0001386|MESH:D014609|GAID:1285|UMLS:C0042173|FMA:55022	hp.json	uvula palatina|palatine uvula|uvula palatina|uvula|uvula of palate	http://purl.obolibrary.org/obo/UBERON_0001734		pheno_slim|efo_slim|uberon_slim
UBERON:0001733	biolink:AnatomicalEntity	soft palate	The muscular, non-bony arch-shaped posterior portion of the palate extending from the posterior edge of the hard palate.	FMA:55021|UMLS:C0030219|MA:0002412|MAT:0000039|MIAA:0000039|EMAPA:18949|BTO:0005405|NCIT:C12231|MESH:D010160|GAID:1284	hp.json	velum palatinum|muscular palate|palatum molle|velum	http://purl.obolibrary.org/obo/UBERON_0001733		pheno_slim|uberon_slim
UBERON:0001736	biolink:AnatomicalEntity	submandibular gland	Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible.	UMLS:C0038556|MA:0001589|FMA:55093|BTO:0001316|NCIT:C12233|CALOHA:TS-0988|MESH:D013363|EFO:0001387|EMAPA:18812|GAID:942|EV:0100061|VHOG:0000364	hp.json	mandibular salivary gland|maxillary gland|submaxillary gland|mandibular gland|glandula submandibularis|submandibular salivary gland	http://purl.obolibrary.org/obo/UBERON_0001736		uberon_slim|pheno_slim|efo_slim
UBERON:0001735	biolink:AnatomicalEntity	tonsillar ring	The circular lymphoid tissue formed by the lingual, pharyngeal, and facial tonsils.	MA:0000752|UMLS:C0459892|FMA:55070|NCIT:C73468	hp.json	Waldeyer's ring|Waldeyer's tonsillar ring|oropharyngeal lymphoid tissue|anulus lymphoideus pharyngis|pharyngeal lymphoid ring|pharyngeal lymphatic ring	http://purl.obolibrary.org/obo/UBERON_0001735		pheno_slim|uberon_slim
CHEBI:48360	biolink:ChemicalSubstance	amphiprotic solvent	Self-ionizing solvent possessing both characteristics of Bronsted acids and bases.		hp.json	amphiprotic solvent	http://purl.obolibrary.org/obo/CHEBI_48360		3_STAR
UBERON:0013720	biolink:AnatomicalEntity	dartos muscle of labia majora	A dartos muscle that is part of a female reproductive system.		hp.json	dartos muliebris|dartos layer of labia	http://purl.obolibrary.org/obo/UBERON_0013720		
UBERON:0013721	biolink:AnatomicalEntity	deep inguinal ring	The entrance to the inguinal canal.	FMA:19927|NCIT:C32832	hp.json	internal inguinal ring|internal ring|annulus inguinalis profundus|internal abdominal ring|abdominal inguinal ring	http://purl.obolibrary.org/obo/UBERON_0013721		
UBERON:0013718	biolink:AnatomicalEntity	dartos muscle	The dartos fascia is a fat-free layer of smooth muscular fiber outside the external spermatic fascia but below the skin. It is a continuation of Scarpa's Fascia which is a membranous layer of the subcutaneous tissue in the abdominal wall.	FMA:18088	hp.json	tunica dartos|dartos muscle|dartos tunic	http://purl.obolibrary.org/obo/UBERON_0013718		
UBERON:0013719	biolink:AnatomicalEntity	dartos muscle of scrotum	A dartos muscle that is part of a male reproductive system.	FMA:27647	hp.json	dartos layer of scrotum|dartos tunic	http://purl.obolibrary.org/obo/UBERON_0013719		
HP:0008569	biolink:PhenotypicFeature	Microtia, second degree	Median longitudinal length of the ear more than two standard deviations below the mean in the presence of some, but not all, parts of the normal ear.	UMLS:C4020797|UMLS:C4020796|UMLS:C4020795|UMLS:C4020794|UMLS:C4020793|UMLS:C4020694|UMLS:C4020792	hp.json	Cockleshell ear|Shell ear|Constricted helix type IV|Severe cupped ear, type III|Ear, grade II dysplasia|Snail ear|Mini ear	http://purl.obolibrary.org/obo/HP_0008569		
HP:0008568	biolink:PhenotypicFeature	Vestibular areflexia	Vestibular areflexia can be measured as the absence of the caloric nystagmus response in electronystagmography.	SNOMEDCT_US:22443004|UMLS:C4015052|UMLS:C0235927	hp.json	Vestibular ataxia	http://purl.obolibrary.org/obo/HP_0008568		
UBERON:0001740	biolink:AnatomicalEntity	arytenoid cartilage	The paired triangular laryngeal cartilages located postlaterally at the level of the thyroid cartilage.	EMAPA:18695|FMA:55109|AAO:0000674|GAID:109|MA:0001759|EMAPA:17977|MESH:D001193|UMLS:C0003943|NCIT:C32148	hp.json	arytenoid|arytenoids|cartilago arytaenoidea|cartilagines arytenoidea|cartilago arytenoidea	http://purl.obolibrary.org/obo/UBERON_0001740		pheno_slim|uberon_slim
UBERON:0001743	biolink:AnatomicalEntity	ligament of larynx	A ligament that is part of a larynx and connexts the cartilages of the larynx.	EMAPA:37626|UMLS:C0458519|NCIT:C32933|MA:0001755|FMA:55131	hp.json	laryngeal ligament|larynx ligament	http://purl.obolibrary.org/obo/UBERON_0001743		
UBERON:0001742	biolink:AnatomicalEntity	epiglottic cartilage	The most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing.	EMAPA:37522|UMLS:C0458526|FMA:55112|NCIT:C32526|MA:0001763	hp.json		http://purl.obolibrary.org/obo/UBERON_0001742		uberon_slim
UBERON:0001727	biolink:AnatomicalEntity	taste bud	A specialized receptor organ that is a collection of cells spanning the gustatory epithelium.	EMAPA:35850|CALOHA:TS-1015|XAO:0000445|OpenCyc:Mx4rvVjan5wpEbGdrcN5Y29ycA|UMLS:C0039337|VHOG:0000130|BTO:0000989|BIRNLEX:4101|FMA:54825|SCTID:362099006|http://uri.neuinfo.org/nif/nifstd/nifext_14|GAID:815|ZFA:0001074|AAO:0010573|MESH:D013650|MA:0001591|NCIT:C96518|Wikipedia:Taste_bud|UMLS:C0039337|TAO:0001074	hp.json	taste-bud|caliculus gustatorius|caliculus gustatorius|tastebud|caliculus gustatorius|taste buds|taste buds|caliculus gustatorius|taste-bud|tastebuds|tastebuds|tastebud	http://purl.obolibrary.org/obo/UBERON_0001727		uberon_slim|vertebrate_core|pheno_slim
CHEBI:48356	biolink:ChemicalSubstance	protic solvent	A polar solvent that is capable of acting as a hydron (proton) donor.		hp.json	protogenic solvent	http://purl.obolibrary.org/obo/CHEBI_48356		3_STAR
UBERON:0001726	biolink:AnatomicalEntity	papilla of tongue		FMA:54819|BIRNLEX:4102|NCIT:C33258|UMLS:C0226964|UMLS:C0226964|EMAPA:32777|MA:0001593|UMLS:C1289183|SCTID:368728006	hp.json	lingual papilla|tongue papilla	http://purl.obolibrary.org/obo/UBERON_0001726		pheno_slim
CHEBI:48359	biolink:ChemicalSubstance	protophilic solvent	Solvent that is capable of acting as a hydron (proton) acceptor.		hp.json	hydrogen bond acceptor solvent|HBA solvent|protophilic solvent	http://purl.obolibrary.org/obo/CHEBI_48359		3_STAR
UBERON:0001728	biolink:AnatomicalEntity	nasopharynx	The section of the pharynx that lies above the soft palate.	CALOHA:TS-0663|VHOG:0000375|EHDAA:7086|UMLS:C0027442|EHDAA2:0001239|MA:0000443|MAT:0000447|NCIT:C12423|FMA:54878|EMAPA:17670|MESH:D009305|EV:0100066|OpenCyc:Mx4rwUPoDJwpEbGdrcN5Y29ycA|BTO:0000662|GAID:339	hp.json	pars nasalis pharyngis|nasal part of pharynx|epipharynx|rhinopharynx|Nasenrachenraum	http://purl.obolibrary.org/obo/UBERON_0001728		uberon_slim|pheno_slim
UBERON:0001723	biolink:AnatomicalEntity	tongue	A muscular organ in the floor of the mouth.	EHDAA2:0002062|EHDAA:9144|SCTID:181226008|UMLS:C0040408|MA:0000347|MIAA:0000040|EFO:0000833|VHOG:0000419|NCIT:C12422|ZFA:0005333|EV:0100058|CALOHA:TS-1050|GAID:816|EMAPA:17185|OpenCyc:Mx4rvVjmJ5wpEbGdrcN5Y29ycA_53KXLq9EdqAAAACs6hnmQ|MESH:D014059|Wikipedia:Tongue|TAO:0005333|FMA:54640|AAO:0010360|BTO:0001385|XAO:0000446|MAT:0000040	hp.json	glossus|glossus	http://purl.obolibrary.org/obo/UBERON_0001723		uberon_slim|vertebrate_core|organ_slim|pheno_slim|efo_slim
OBO:uberon/core#distally_connected_to	biolink:NamedThing	distally connected to	x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y.		hp.json		http://purl.obolibrary.org/obo/uberon/core#distally_connected_to		
UBERON:0001725	biolink:AnatomicalEntity	cranial synchondrosis	The cartilaginous joints of the skull; these include sphenoethmoidal synchondrosis, sphenooccipital synchondrosis, sphenopetrosal synchondrosis, petrooccipital synchondrosis, anterior intraoccipital synchondrosis and posterior intraoccipital synchondrosis.	MA:0001502|FMA:54816|EMAPA:35264	hp.json		http://purl.obolibrary.org/obo/UBERON_0001725		
UBERON:0001724	biolink:AnatomicalEntity	sphenoidal sinus	One of the paired paranasal sinuses, located in the body of the sphenoid bone and communicating with the highest meatus of the nasal cavity on the same side[MESH]. The sphenoidal sinuses (or sphenoid) contained within the body of the sphenoid vary in size and shape; owing to the lateral displacement of the intervening septum they are rarely symmetrical. The following are their average measurements: vertical height, 2.2 cm. ; transverse breadth, 2 cm. ; antero-posterior depth, 2.2 cm. [WP,unvetted].	OpenCyc:Mx4rwEIoz5wpEbGdrcN5Y29ycA|MA:0001795|NCIT:C12278|UMLS:C0037885|MESH:D013101|GAID:359|FMA:54683	hp.json	sphenoid sinus|sinus sphenoidalis	http://purl.obolibrary.org/obo/UBERON_0001724		uberon_slim|pheno_slim
CHEBI:24384	biolink:ChemicalSubstance	glycogens			hp.json		http://purl.obolibrary.org/obo/CHEBI_24384		3_STAR
CHEBI:48355	biolink:ChemicalSubstance	non-polar solvent			hp.json		http://purl.obolibrary.org/obo/CHEBI_48355		1_STAR
CHEBI:48354	biolink:ChemicalSubstance	polar solvent	A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds.		hp.json	polar solvents|polar solvent	http://purl.obolibrary.org/obo/CHEBI_48354		3_STAR
UBERON:0013705	biolink:AnatomicalEntity	fascia of Scarpa	The deep layer (fascia of Scarpa) is a layer of the anterior abdominal wall.	FMA:19923	hp.json	Colles fascia|Scarpa's fascia|fascia of Scarpa|stratum membranosum telae subcutaneae abdominis|Scarpa's fascia|membranous layer of subcutaneous tissue of abdomen|membranous layer of superficial fascia of abdomen|deep layer of superficial fascia of abdomen|Colles' fascia	http://purl.obolibrary.org/obo/UBERON_0013705		
UBERON:0013701	biolink:AnatomicalEntity	main body axis	A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages.		hp.json		http://purl.obolibrary.org/obo/UBERON_0013701		non_informative
UBERON:0013702	biolink:AnatomicalEntity	body proper	The region of the organism associated with the visceral organs.	EMAPA:36031|BTO:0001489|FMA:231424|AEO:0000103	hp.json	whole body|body	http://purl.obolibrary.org/obo/UBERON_0013702		non_informative
UBERON:0013703	biolink:AnatomicalEntity	integumentary projection	Anatomical projection that is part of the integumentl system.		hp.json	skin projection	http://purl.obolibrary.org/obo/UBERON_0013703		
UBERON:0013704	biolink:AnatomicalEntity	notochordal canal	A tubular passage that extends from the primitive pit into the head process during the early stages of embryonic development in mammals. It perforates the splanchnopleure layer so that the yolk sac and the amnion are connected temporarily.	FMA:293127|UMLS:C1518428|NCIT:C34230	hp.json	chordal canal	http://purl.obolibrary.org/obo/UBERON_0013704		
HP:0008537	biolink:PhenotypicFeature	Cleft at the superior portion of the pinna		UMLS:C1865302	hp.json	Cleft at the superior portion of the ear	http://purl.obolibrary.org/obo/HP_0008537		
CHEBI:36360	biolink:ChemicalSubstance	phosphorus oxoacids and derivatives			hp.json		http://purl.obolibrary.org/obo/CHEBI_36360		1_STAR
UBERON:0001730	biolink:AnatomicalEntity	extrinsic ligament of larynx		EMAPA:37627|FMA:54921|MA:0001756	hp.json	laryngeal extrinsic ligament	http://purl.obolibrary.org/obo/UBERON_0001730		
UBERON:0001732	biolink:AnatomicalEntity	pharyngeal tonsil	The lymph tissue in the roof and posterior wall of the nasopharynx.	MA:0000774|BTO:0000777|UMLS:C0001428|MESH:D000234|GAID:1288|EV:0100054|FMA:54970|NCIT:C33318	hp.json	adenoid|tonsilla pharyngealis|nasopharyngeal tonsil|tonsil of Luschka|tonsilla pharyngea|Rachenmandel	http://purl.obolibrary.org/obo/UBERON_0001732		pheno_slim|uberon_slim
UBERON:0001731	biolink:AnatomicalEntity	cavity of pharynx	An anatomical space that is enclosed by a pharynx.	SCTID:180543003|AAO:0010435|FMA:54935|BSA:0000113|EMAPA:18381|XAO:0000105|BTO:0002097	hp.json	pharyngeal cavity|cavitas pharyngealis|cavitas pharyngis|lumen of pharynx	http://purl.obolibrary.org/obo/UBERON_0001731		
UBERON:0001716	biolink:AnatomicalEntity	secondary palate	The part of the palate formed from the fusion of the two palatine shelves, extensions of the maxillary prominences.	NCIT:C34292|UMLS:C1519217|NCIT:C12229|MESH:D010159|MA:0002476|BTO:0001779|FMA:54549|GAID:152|UMLS:C0700374|EMAPA:18948|galen:Palate	hp.json	roof of mouth|palatum|definitive palate|palatum definitivum|palatum|palatum secundarium|palate|oral roof	http://purl.obolibrary.org/obo/UBERON_0001716		uberon_slim|pheno_slim
UBERON:0001715	biolink:AnatomicalEntity	oculomotor nuclear complex	Nuclear complex containing subnuclei that give rise to the axons of the occulomotor nerve, both motor and parasympathetic fibers, situated at the midline at the level of the superior colliculus in the midbrain tegmentum (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 533-534).	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=492|BAMS:III|VHOG:0001389|EV:0100250|MBA:35|BM:MB-III|BAMS:3|ZFA:0000553|NCIT:C12897|UMLS:C0228686|XAO:0004389|BIRNLEX:1240|TAO:0000553|UMLS:C0228686|EMAPA:35605|DHBA:12198|EFO:0002468|HBA:9030|MA:0001073|EHDAA2:0004211|MESH:D065838|FMA:54510	hp.json	nucleus nervi oculomotorii|nucleus of oculomotor nerve|OM|nucleus nervi oculomotorii|nucleus oculomotorius|oculomotor nucleus|oculomotor III nuclear complex|oculomotor motornucleus|motor nucleus III|nucleus of third cranial nerve|oculomotor III nucleus|third cranial nerve nucleus|nucleus of oculomotor nuclear complex|nIII	http://purl.obolibrary.org/obo/UBERON_0001715		uberon_slim|vertebrate_core|pheno_slim|efo_slim
GO:0097386	biolink:CellularComponent	glial cell projection	A prolongation or process extending from a glial cell.		hp.json	glial projection|glial process	http://purl.obolibrary.org/obo/GO_0097386		
UBERON:0001712	biolink:AnatomicalEntity	upper eyelid		OpenCyc:Mx4rvg4ohJwpEbGdrcN5Y29ycA|NCIT:C49581|MA:0001267|FMA:54439|EHDAA2:0002115|UMLS:C0585636|VHOG:0000389|EHDAA:9047|EMAPA:17834	hp.json	palpebra superior|superior eyelid	http://purl.obolibrary.org/obo/UBERON_0001712		uberon_slim|pheno_slim
UBERON:0001711	biolink:AnatomicalEntity	eyelid	A fold of skin that covers and protects part of the eyeball. Examples: upper eyelid, lower eyelid, nictitating membrane.	MESH:D005143|GAID:72|BTO:0002241|NCIT:C12713|EV:0100338|MA:0000268|EHDAA2:0000487|EMAPA:17829|FMA:54437|OpenCyc:Mx4rvVi4m5wpEbGdrcN5Y29ycA|VHOG:0000016|EHDAA:9037|UMLS:C0015426	hp.json	blepharon|palpebra|blephara|eye lid|palpebrae	http://purl.obolibrary.org/obo/UBERON_0001711		uberon_slim|pheno_slim
UBERON:0001714	biolink:AnatomicalEntity	cranial ganglion	The groups of nerve cell bodies associated with the twelve cranial nerves.	XAO:0000027|SCTID:244448001|BIRNLEX:2597|VHOG:0000076|EFO:0000902|MA:0000214|MA:0000213|Wikipedia:Cranial_nerve_ganglion|ZFA:0000013|TAO:0000013|BTO:0000106|MAT:0000200|FMA:54502|EMAPA:16659|MIAA:0000200	hp.json	cranial ganglia|ganglion of cranial nerve|cranial ganglion/nerve|ganglion of cranial neural tree organ|cranial ganglion part of peripheral nervous system|cranial nerve ganglion|head ganglion|cranial neural ganglion|cranial ganglion|cranial neural tree organ ganglion|presumptive cranial ganglia	http://purl.obolibrary.org/obo/UBERON_0001714		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0001713	biolink:AnatomicalEntity	lower eyelid		VHOG:0000388|FMA:54442|XAO:0000007|EMAPA:17831|NCIT:C49580|AAO:0010349|EHDAA:9041|UMLS:C0229258|EHDAA2:0001015|OpenCyc:Mx4rvW6GtJwpEbGdrcN5Y29ycA|MA:0001263	hp.json	palpebra inferior|inferior eyelid	http://purl.obolibrary.org/obo/UBERON_0001713		uberon_slim|pheno_slim
UBERON:0013700	biolink:AnatomicalEntity	axial musculature	Musculature of the head and neck, spine, and ribs.	EHDAA2:0000159|EMAPA:18166	hp.json		http://purl.obolibrary.org/obo/UBERON_0013700		
CHEBI:24396	biolink:ChemicalSubstance	glycopeptide	Any carbohydrate derivative that consists of glycan moieties covalently attached to the side chains of the amino acid residues that constitute the peptide.		hp.json	glycopeptides	http://purl.obolibrary.org/obo/CHEBI_24396		3_STAR
CHEBI:48343	biolink:ChemicalSubstance	disulfide	Compounds of structure RSSR'.		hp.json	disulfides	http://purl.obolibrary.org/obo/CHEBI_48343		3_STAR
HP:0008542	biolink:PhenotypicFeature	Low-frequency hearing loss	A type of hearing impairment affecting primarily the low frequencies of sound (125 Hz to 1000 Hz).	SNOMEDCT_US:42538001|UMLS:C0271514	hp.json	Low-frequency hearing loss	http://purl.obolibrary.org/obo/HP_0008542		
UBERON:0001720	biolink:AnatomicalEntity	cochlear nucleus	Any of the nuclei of the cochlear nuclear complex.	MESH:D017626|MA:0001012|FMA:54603|TAO:0002243|ZFA:0001638|EMAPA:35248|NCIT:C12837|GAID:601	hp.json	nucleus of cochlear nerve|vestibulocochlear nucleus|cochlear nucleus of acoustic nerve|statoacoustic (VIII) nucleus|cochlear VIII nucleus|cochlear nucleus of eighth cranial nerve	http://purl.obolibrary.org/obo/UBERON_0001720		vertebrate_core|pheno_slim|uberon_slim
HP:0008544	biolink:PhenotypicFeature	Abnormally folded helix	Any structural anomaly of the border of the helix, which usually forms a rolled rim but is highly variable in shape.	UMLS:C1970777	hp.json		http://purl.obolibrary.org/obo/HP_0008544		
HP:0008541	biolink:PhenotypicFeature	Superiorly displaced ears		UMLS:C1850190	hp.json	High set ears	http://purl.obolibrary.org/obo/HP_0008541		
GO:0048341	biolink:BiologicalProcess	paraxial mesoderm formation	The process that gives rise to the paraxial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.		hp.json		http://purl.obolibrary.org/obo/GO_0048341		
GO:0048340	biolink:BiologicalProcess	paraxial mesoderm morphogenesis	The process in which the anatomical structures of the paraxial mesoderm are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0048340		
GO:2000106	biolink:BiologicalProcess	regulation of leukocyte apoptotic process	Any process that modulates the frequency, rate or extent of leukocyte apoptotic process.		hp.json	regulation of leukocyte apoptosis	http://purl.obolibrary.org/obo/GO_2000106		
GO:2000107	biolink:BiologicalProcess	negative regulation of leukocyte apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process.		hp.json	negative regulation of leukocyte apoptosis	http://purl.obolibrary.org/obo/GO_2000107		
GO:2000108	biolink:BiologicalProcess	positive regulation of leukocyte apoptotic process	Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process.		hp.json	positive regulation of leukocyte apoptosis	http://purl.obolibrary.org/obo/GO_2000108		
GO:2000109	biolink:BiologicalProcess	regulation of macrophage apoptotic process	Any process that modulates the frequency, rate or extent of macrophage apoptotic process.		hp.json	regulation of activation-induced cell death|regulation of AICD|regulation of macrophage apoptosis	http://purl.obolibrary.org/obo/GO_2000109		
GO:0061323	biolink:BiologicalProcess	cell proliferation involved in heart morphogenesis	The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0061323		
GO:0061325	biolink:BiologicalProcess	cell proliferation involved in outflow tract morphogenesis	The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to the shaping of the outflow tract.		hp.json		http://purl.obolibrary.org/obo/GO_0061325		
OBO:uberon/core#channel_for	biolink:NamedThing	channel for			hp.json	carries	http://purl.obolibrary.org/obo/uberon/core#channel_for		
GO:0061311	biolink:BiologicalProcess	cell surface receptor signaling pathway involved in heart development	The series of molecular signals initiated by a ligand the binding to its receptor on the surface of a cell, which contributes to the progression of the heart over time.		hp.json	cell surface receptor linked signaling pathway involved in heart development|cell surface receptor linked signalling pathway involved in heart development	http://purl.obolibrary.org/obo/GO_0061311		
GO:2000110	biolink:BiologicalProcess	negative regulation of macrophage apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process.		hp.json	negative regulation of AICD|negative regulation of activation-induced cell death|negative regulation of macrophage apoptosis	http://purl.obolibrary.org/obo/GO_2000110		
GO:2000111	biolink:BiologicalProcess	positive regulation of macrophage apoptotic process	Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process.		hp.json	positive regulation of macrophage apoptosis|positive regulation of activation-induced cell death|positive regulation of AICD	http://purl.obolibrary.org/obo/GO_2000111		
GO:2000112	biolink:BiologicalProcess	regulation of cellular macromolecule biosynthetic process	Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process.		hp.json	regulation of cellular macromolecule anabolism|regulation of cellular biopolymer biosynthetic process|regulation of cellular macromolecule synthesis|regulation of cellular macromolecule formation|regulation of cellular macromolecule biosynthesis	http://purl.obolibrary.org/obo/GO_2000112		
GO:2000113	biolink:BiologicalProcess	negative regulation of cellular macromolecule biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process.		hp.json	negative regulation of cellular macromolecule biosynthesis|negative regulation of cellular macromolecule anabolism|negative regulation of cellular biopolymer biosynthetic process|negative regulation of cellular macromolecule synthesis|negative regulation of cellular macromolecule formation	http://purl.obolibrary.org/obo/GO_2000113		
GO:2000114	biolink:BiologicalProcess	regulation of establishment of cell polarity	Any process that modulates the frequency, rate or extent of establishment of cell polarity.		hp.json	regulation of bud site selection/establishment of cell polarity|regulation of cell polarization	http://purl.obolibrary.org/obo/GO_2000114		
GO:1903768	biolink:CellularComponent	taste receptor complex	A protein complex which is capable of taste receptor activity.		hp.json		http://purl.obolibrary.org/obo/GO_1903768		
GO:0048369	biolink:BiologicalProcess	lateral mesoderm morphogenesis	The process in which the anatomical structures of the lateral mesoderm are generated and organized.		hp.json	lateral plate mesoderm morphogenesis	http://purl.obolibrary.org/obo/GO_0048369		
GO:0048368	biolink:BiologicalProcess	lateral mesoderm development	The process whose specific outcome is the progression of the lateral mesoderm over time, from its formation to the mature structure.		hp.json	lateral plate mesoderm development	http://purl.obolibrary.org/obo/GO_0048368		
GO:1903771	biolink:BiologicalProcess	positive regulation of beta-galactosidase activity	Any process that activates or increases the frequency, rate or extent of beta-galactosidase activity.		hp.json	activation of beta-galactosidase activity|upregulation of lactose hydrolysis|up regulation of oryzatym|up regulation of maxilact|upregulation of lactozym|activation of S 2107|activation of beta-D-lactosidase activity|positive regulation of beta-D-lactosidase activity|activation of sumiklat|up-regulation of beta-D-galactoside galactohydrolase activity|positive regulation of exo-(1->4)-beta-D-galactanase activity|up-regulation of hydrolact|upregulation of S 2107|activation of beta-D-galactoside galactohydrolase activity|upregulation of sumiklat|up-regulation of oryzatym|up-regulation of maxilact|positive regulation of lactozym|up regulation of exo-(1->4)-beta-D-galactanase activity|positive regulation of lactose hydrolysis|upregulation of beta-galactosidase activity|up-regulation of beta-D-galactanase activity|upregulation of beta-D-lactosidase activity|up regulation of hydrolact|up-regulation of beta-lactosidase activity|up regulation of lactozym|positive regulation of S 2107|up-regulation of trilactase activity|up regulation of lactose hydrolysis|up regulation of beta-D-galactanase activity|positive regulation of hydrolact|positive regulation of sumiklat|up-regulation of exo-(1->4)-beta-D-galactanase activity|up regulation of beta-lactosidase activity|up regulation of S 2107|activation of exo-(1->4)-beta-D-galactanase activity|up regulation of trilactase activity|upregulation of beta-D-galactoside galactohydrolase activity|activation of beta-D-galactanase activity|up-regulation of lactozym|up-regulation of lactose hydrolysis|activation of oryzatym|up regulation of sumiklat|positive regulation of beta-D-galactanase activity|activation of maxilact|upregulation of oryzatym|activation of beta-lactosidase activity|positive regulation of beta-lactosidase activity|upregulation of maxilact|positive regulation of trilactase activity|up-regulation of S 2107|upregulation of hydrolact|up-regulation of beta-galactosidase activity|activation of trilactase activity|up-regulation of beta-D-lactosidase activity|up-regulation of sumiklat|activation of hydrolact|upregulation of beta-D-galactanase activity|positive regulation of beta-D-galactoside galactohydrolase activity|positive regulation of maxilact|up regulation of beta-galactosidase activity|upregulation of beta-lactosidase activity|positive regulation of oryzatym|upregulation of exo-(1->4)-beta-D-galactanase activity|up regulation of beta-D-lactosidase activity|activation of lactose hydrolysis|activation of lactozym|up regulation of beta-D-galactoside galactohydrolase activity|upregulation of trilactase activity	http://purl.obolibrary.org/obo/GO_1903771		
GO:0061343	biolink:BiologicalProcess	cell adhesion involved in heart morphogenesis	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules that contributes to the shaping of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0061343		
GO:0061344	biolink:BiologicalProcess	regulation of cell adhesion involved in heart morphogenesis	Any process that modulates the extent of cell adhesion contributing to the shaping of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0061344		
GO:1903770	biolink:BiologicalProcess	negative regulation of beta-galactosidase activity	Any process that stops, prevents or reduces the frequency, rate or extent of beta-galactosidase activity.		hp.json	down regulation of beta-lactosidase activity|downregulation of beta-D-galactoside galactohydrolase activity|down regulation of trilactase activity|downregulation of hydrolact|down-regulation of S 2107|negative regulation of S 2107|downregulation of maxilact|negative regulation of sumiklat|down-regulation of sumiklat|downregulation of oryzatym|downregulation of beta-D-galactanase activity|inhibition of beta-D-galactanase activity|inhibition of lactozym|inhibition of lactose hydrolysis|down-regulation of beta-galactosidase activity|negative regulation of beta-D-lactosidase activity|downregulation of beta-lactosidase activity|inhibition of beta-lactosidase activity|down-regulation of beta-D-lactosidase activity|inhibition of S 2107|inhibition of trilactase activity|downregulation of trilactase activity|down regulation of beta-D-galactoside galactohydrolase activity|inhibition of sumiklat|downregulation of exo-(1->4)-beta-D-galactanase activity|down regulation of maxilact|down regulation of beta-galactosidase activity|inhibition of hydrolact|down regulation of oryzatym|down regulation of beta-D-lactosidase activity|inhibition of beta-D-galactoside galactohydrolase activity|negative regulation of beta-D-galactoside galactohydrolase activity|downregulation of lactozym|downregulation of lactose hydrolysis|down-regulation of beta-D-galactoside galactohydrolase activity|negative regulation of maxilact|down-regulation of maxilact|down-regulation of oryzatym|negative regulation of oryzatym|downregulation of beta-galactosidase activity|down-regulation of hydrolact|inhibition of beta-galactosidase activity|downregulation of S 2107|negative regulation of hydrolact|down regulation of exo-(1->4)-beta-D-galactanase activity|downregulation of beta-D-lactosidase activity|inhibition of beta-D-lactosidase activity|downregulation of sumiklat|down regulation of lactose hydrolysis|negative regulation of beta-D-galactanase activity|inhibition of exo-(1->4)-beta-D-galactanase activity|down regulation of lactozym|down-regulation of beta-D-galactanase activity|down-regulation of beta-lactosidase activity|negative regulation of exo-(1->4)-beta-D-galactanase activity|down regulation of hydrolact|down-regulation of exo-(1->4)-beta-D-galactanase activity|inhibition of oryzatym|inhibition of maxilact|negative regulation of beta-lactosidase activity|negative regulation of trilactase activity|down-regulation of trilactase activity|down regulation of S 2107|down-regulation of lactose hydrolysis|negative regulation of lactozym|down-regulation of lactozym|down regulation of beta-D-galactanase activity|negative regulation of lactose hydrolysis|down regulation of sumiklat	http://purl.obolibrary.org/obo/GO_1903770		
GO:0036334	biolink:BiologicalProcess	epidermal stem cell homeostasis	Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells.		hp.json		http://purl.obolibrary.org/obo/GO_0036334		
GO:0036336	biolink:BiologicalProcess	dendritic cell migration	The movement of a dendritic cell within or between different tissues and organs of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0036336		
GO:0048370	biolink:BiologicalProcess	lateral mesoderm formation	The process that gives rise to the lateral mesoderm. This process pertains to the initial formation of the structure from unspecified parts.		hp.json	lateral plate mesoderm biosynthesis|lateral plate mesoderm formation	http://purl.obolibrary.org/obo/GO_0048370		
GO:1903779	biolink:BiologicalProcess	regulation of cardiac conduction	Any process that modulates the frequency, rate or extent of cardiac conduction.		hp.json		http://purl.obolibrary.org/obo/GO_1903779		
GO:2000137	biolink:BiologicalProcess	negative regulation of cell proliferation involved in heart morphogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_2000137		
GO:1903778	biolink:BiologicalProcess	protein localization to vacuolar membrane	A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane.		hp.json	protein localisation in vacuolar membrane|protein localization in vacuolar membrane|protein localisation to vacuolar membrane	http://purl.obolibrary.org/obo/GO_1903778		
GO:2000138	biolink:BiologicalProcess	positive regulation of cell proliferation involved in heart morphogenesis	Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_2000138		
GO:1903781	biolink:BiologicalProcess	positive regulation of cardiac conduction	Any process that activates or increases the frequency, rate or extent of cardiac conduction.		hp.json	upregulation of cardiac conduction|up regulation of cardiac conduction|up-regulation of cardiac conduction|activation of cardiac conduction	http://purl.obolibrary.org/obo/GO_1903781		
GO:1903780	biolink:BiologicalProcess	negative regulation of cardiac conduction	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac conduction.		hp.json	down regulation of cardiac conduction|inhibition of cardiac conduction|down-regulation of cardiac conduction|downregulation of cardiac conduction	http://purl.obolibrary.org/obo/GO_1903780		
GO:0061337	biolink:BiologicalProcess	cardiac conduction	Transfer of an organized electrical impulse across the heart to coordinate the contraction of cardiac muscles. The process begins with generation of an action potential (in the sinoatrial node (SA) in humans) and ends with a change in the rate, frequency, or extent of the contraction of the heart muscles.		hp.json		http://purl.obolibrary.org/obo/GO_0061337		
GO:2000136	biolink:BiologicalProcess	regulation of cell proliferation involved in heart morphogenesis	Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_2000136		
GO:1903789	biolink:BiologicalProcess	regulation of amino acid transmembrane transport	Any process that modulates the frequency, rate or extent of amino acid transmembrane transport.		hp.json	regulation of amino acid membrane transport	http://purl.obolibrary.org/obo/GO_1903789		
GO:0048389	biolink:BiologicalProcess	intermediate mesoderm development	The process whose specific outcome is the progression of the intermediate mesoderm over time, from its formation to the mature structure. The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.		hp.json		http://purl.obolibrary.org/obo/GO_0048389		
GO:1903793	biolink:BiologicalProcess	positive regulation of anion transport	Any process that activates or increases the frequency, rate or extent of anion transport.		hp.json	activation of anion transport|upregulation of anion transport|up-regulation of anion transport|up regulation of anion transport	http://purl.obolibrary.org/obo/GO_1903793		
GO:1903792	biolink:BiologicalProcess	negative regulation of anion transport	Any process that stops, prevents or reduces the frequency, rate or extent of anion transport.		hp.json	down-regulation of anion transport|down regulation of anion transport|inhibition of anion transport|downregulation of anion transport	http://purl.obolibrary.org/obo/GO_1903792		
GO:0048390	biolink:BiologicalProcess	intermediate mesoderm morphogenesis	The process in which the anatomical structures of the intermediate mesoderm are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0048390		
GO:0048391	biolink:BiologicalProcess	intermediate mesoderm formation	The process that gives rise to the intermediate mesoderm. This process pertains to the initial formation of the structure from unspecified parts.		hp.json		http://purl.obolibrary.org/obo/GO_0048391		
GO:1901137	biolink:BiologicalProcess	carbohydrate derivative biosynthetic process	The chemical reactions and pathways resulting in the formation of carbohydrate derivative.		hp.json	carbohydrate derivative anabolism|carbohydrate derivative synthesis|carbohydrate derivative biosynthesis|carbohydrate derivative formation	http://purl.obolibrary.org/obo/GO_1901137		
GO:1903797	biolink:BiologicalProcess	positive regulation of inorganic anion transmembrane transport	Any process that activates or increases the frequency, rate or extent of inorganic anion transmembrane transport.		hp.json	up regulation of inorganic anion transmembrane transport|up regulation of transmembrane inorganic anion transport|activation of inorganic anion transmembrane transport|activation of transmembrane inorganic anion transport|positive regulation of transmembrane inorganic anion transport|upregulation of inorganic anion membrane transport|upregulation of inorganic anion transmembrane transport|upregulation of transmembrane inorganic anion transport|positive regulation of inorganic anion membrane transport|up regulation of inorganic anion membrane transport|up-regulation of inorganic anion membrane transport|activation of inorganic anion membrane transport|up-regulation of inorganic anion transmembrane transport|up-regulation of transmembrane inorganic anion transport	http://purl.obolibrary.org/obo/GO_1903797		
GO:1903796	biolink:BiologicalProcess	negative regulation of inorganic anion transmembrane transport	Any process that stops, prevents or reduces the frequency, rate or extent of inorganic anion transmembrane transport.		hp.json	down regulation of inorganic anion membrane transport|inhibition of inorganic anion membrane transport|down-regulation of inorganic anion membrane transport|negative regulation of inorganic anion membrane transport|negative regulation of transmembrane inorganic anion transport|down-regulation of transmembrane inorganic anion transport|down-regulation of inorganic anion transmembrane transport|down regulation of transmembrane inorganic anion transport|down regulation of inorganic anion transmembrane transport|downregulation of inorganic anion membrane transport|downregulation of inorganic anion transmembrane transport|inhibition of transmembrane inorganic anion transport|inhibition of inorganic anion transmembrane transport|downregulation of transmembrane inorganic anion transport	http://purl.obolibrary.org/obo/GO_1903796		
GO:1901135	biolink:BiologicalProcess	carbohydrate derivative metabolic process	The chemical reactions and pathways involving carbohydrate derivative.		hp.json	carbohydrate derivative metabolism	http://purl.obolibrary.org/obo/GO_1901135		goslim_generic|goslim_agr|prokaryote_subset|goslim_mouse
GO:0061351	biolink:BiologicalProcess	neural precursor cell proliferation	The multiplication or reproduction of neural precursor cells, resulting in the expansion of a cell population. A neural precursor cell is either a nervous system stem cell or a nervous system progenitor cell.		hp.json		http://purl.obolibrary.org/obo/GO_0061351		
GO:1903795	biolink:BiologicalProcess	regulation of inorganic anion transmembrane transport	Any process that modulates the frequency, rate or extent of inorganic anion transmembrane transport.		hp.json	regulation of transmembrane inorganic anion transport|regulation of inorganic anion membrane transport	http://purl.obolibrary.org/obo/GO_1903795		
GO:0097324	biolink:BiologicalProcess	melanocyte migration	The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.		hp.json		http://purl.obolibrary.org/obo/GO_0097324		
GO:1901148	biolink:BiologicalProcess	gene expression involved in extracellular matrix organization	Any gene expression that is involved in extracellular matrix organization. Gene expression includes both transcription to produce an RNA transcript, and the translation of that mRNA into protein. Protein maturation is included in gene expression when required to form an active form of a product from an inactive precursor form.		hp.json	expression of extracellular matrix proteins|extracellular matrix protein production	http://purl.obolibrary.org/obo/GO_1901148		
GO:0061383	biolink:BiologicalProcess	trabecula morphogenesis	The process of shaping a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0061383		
GO:0061385	biolink:BiologicalProcess	fibroblast proliferation involved in heart morphogenesis	The multiplication or reproduction of fibroblasts, resulting in the expansion of a fibroblast population that contributes to the shaping of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0061385		
GO:1901163	biolink:BiologicalProcess	regulation of trophoblast cell migration	Any process that modulates the frequency, rate or extent of trophoblast cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_1901163		
GO:1901164	biolink:BiologicalProcess	negative regulation of trophoblast cell migration	Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.		hp.json	downregulation of trophoblast cell migration|down regulation of trophoblast cell migration|inhibition of trophoblast cell migration|down-regulation of trophoblast cell migration	http://purl.obolibrary.org/obo/GO_1901164		
GO:1901162	biolink:BiologicalProcess	primary amino compound biosynthetic process	The chemical reactions and pathways resulting in the formation of primary amino compound.		hp.json	primary amino compound anabolism|primary amino compound biosynthesis|primary amino compound synthesis|primary amino compound formation	http://purl.obolibrary.org/obo/GO_1901162		
GO:1901160	biolink:BiologicalProcess	primary amino compound metabolic process	The chemical reactions and pathways involving primary amino compound.		hp.json	primary amino compound metabolism	http://purl.obolibrary.org/obo/GO_1901160		
UBERON:0011191	biolink:AnatomicalEntity	ophthalmic vein	Ophthalmic veins are veins which drain the eye. More specifically, they can refer to: Superior ophthalmic vein Inferior ophthalmic vein.	EHDAA2:0004113|EMAPA:19313|XAO:0004169	hp.json	vena ophthalmica|opthalmic vein	http://purl.obolibrary.org/obo/UBERON_0011191		
UBERON:0011192	biolink:AnatomicalEntity	superior ophthalmic vein	The superior ophthalmic vein begins at the inner angle of the orbit in a vein named the nasofrontal which communicates anteriorly with the angular vein; it pursues the same course as the ophthalmic artery, and receives tributaries corresponding to the branches of that vessel. Forming a short single trunk, it passes between the two heads of the Rectus lateralis and through the medial part of the superior orbital fissure, and ends in the cavernous sinus. The ethmoidal veins drain into the superior ophthalmic vein. Vorticose veins also drain into the superior ophthalmic vein.	FMA:51246	hp.json	superior opthalmic vein|posterior ethmoidal vein|superior ophthalmic|anterior ethmoidal vein	http://purl.obolibrary.org/obo/UBERON_0011192		human_reference_atlas
UBERON:0011198	biolink:AnatomicalEntity	muscle layer of large intestine	A muscle layer that is part of a large intestine.	UMLS:C0734205|NCIT:C32927|FMA:14971	hp.json	tunica muscularis intestini crassi|muscularis externa of large intestine|muscular coat of large intestine|muscular layer of large intestine	http://purl.obolibrary.org/obo/UBERON_0011198		
UBERON:0035165	biolink:AnatomicalEntity	posterior surface of prostate	The flattened aspect of the prostate with a slight furrow facing the rectum and anus.	FMA:19592|NCIT:C13095	hp.json	posterior surface of prostate gland|facies posterior (prostatae)|facies posterior prostatae	http://purl.obolibrary.org/obo/UBERON_0035165		
UBERON:0011197	biolink:AnatomicalEntity	parathyroid epithelium	An epithelium that is part of a parathyroid gland.	NCIT:C48258|UMLS:C1709466|CALOHA:TS-2141	hp.json		http://purl.obolibrary.org/obo/UBERON_0011197		
GO:0051919	biolink:BiologicalProcess	positive regulation of fibrinolysis	Any process that activates, maintains or increases the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.		hp.json	up-regulation of fibrinolysis|activation of fibrinolysis|upregulation of fibrinolysis|stimulation of fibrinolysis|up regulation of fibrinolysis	http://purl.obolibrary.org/obo/GO_0051919		
GO:0051917	biolink:BiologicalProcess	regulation of fibrinolysis	Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.		hp.json		http://purl.obolibrary.org/obo/GO_0051917		
GO:0051918	biolink:BiologicalProcess	negative regulation of fibrinolysis	Any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.		hp.json	downregulation of fibrinolysis|down regulation of fibrinolysis|inhibition of fibrinolysis|down-regulation of fibrinolysis	http://purl.obolibrary.org/obo/GO_0051918		
GO:2000185	biolink:BiologicalProcess	regulation of phosphate transmembrane transport	Any process that modulates the frequency, rate or extent of phosphate transmembrane transport.		hp.json	regulation of phosphate membrane transport	http://purl.obolibrary.org/obo/GO_2000185		
CL:0001054	biolink:Cell	CD14-positive monocyte	A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20.		hp.json	monocyte	http://purl.obolibrary.org/obo/CL_0001054		
GO:2000186	biolink:BiologicalProcess	negative regulation of phosphate transmembrane transport	Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport.		hp.json	negative regulation of phosphate membrane transport	http://purl.obolibrary.org/obo/GO_2000186		
GO:2000187	biolink:BiologicalProcess	positive regulation of phosphate transmembrane transport	Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport.		hp.json	positive regulation of phosphate membrane transport	http://purl.obolibrary.org/obo/GO_2000187		
CL:0001059	biolink:Cell	common myeloid progenitor, CD34-positive	A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1.		hp.json	common myeloid precursor, CD34-positive|multipotential myeloid stem cell|myeloid stem cell|CMP|colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte|CFU-GEMM|CFU-S|pluripotent stem cell (bone marrow)	http://purl.obolibrary.org/obo/CL_0001059		
CL:0001050	biolink:Cell	effector CD8-positive, alpha-beta T cell	A CD8-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive.		hp.json	effector CD8-positive, alpha-beta T-cell|effector CD8+ T cell|effector CD8-positive, alpha-beta T lymphocyte|effector CD8-positive, alpha-beta T-lymphocyte	http://purl.obolibrary.org/obo/CL_0001050		
GO:2000181	biolink:BiologicalProcess	negative regulation of blood vessel morphogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_2000181		
UBERON:0035174	biolink:AnatomicalEntity	right ear	The organ of hearing located on the right side of the head.	FMA:53641|NCIT:C81285	hp.json		http://purl.obolibrary.org/obo/UBERON_0035174		
PR:P32754	biolink:Protein	4-hydroxyphenylpyruvate dioxygenase (human)	A 4-hydroxyphenylpyruvate dioxygenase that is encoded in the genome of human.	UniProtKB:P32754	hp.json	4-hydroxyphenylpyruvic acid oxidase (human)|PPD|hHPD|4HPPD (human)|HPD|HPPDase (human)	http://purl.obolibrary.org/obo/PR_P32754		
UBERON:0011185	biolink:AnatomicalEntity	gastrointestinal sphincter	A sphincter muscle that is part of the gastrointestinal system.	NCIT:C32669|UMLS:C1517464	hp.json		http://purl.obolibrary.org/obo/UBERON_0011185		
CHEBI:85234	biolink:ChemicalSubstance	human blood serum metabolite	Any metabolite (endogenous or exogenous) found in human blood serum samples.		hp.json	human blood serum metabolites	http://purl.obolibrary.org/obo/CHEBI_85234		3_STAR
UBERON:0011189	biolink:AnatomicalEntity	lamina propria of large intestine	A lamina propria that is part of a large intestine.	UMLS:C1708644|NCIT:C49298|FMA:15654	hp.json	large intestine lamina propria|lamina propria of mucosa of large intestine|large intestinal lamina propria	http://purl.obolibrary.org/obo/UBERON_0011189		human_reference_atlas
CL:0001066	biolink:Cell	erythroid progenitor cell, mammalian	A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).	BTO:0004911	hp.json	blast forming unit erythroid|colony forming unit erythroid|erythroid stem cell|burst forming unit erythroid|CFU-E|BFU-E	http://purl.obolibrary.org/obo/CL_0001066		
GO:2000195	biolink:BiologicalProcess	negative regulation of female gonad development	Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.		hp.json	negative regulation of ovarian development|negative regulation of ovary development	http://purl.obolibrary.org/obo/GO_2000195		
GO:2000196	biolink:BiologicalProcess	positive regulation of female gonad development	Any process that activates or increases the frequency, rate or extent of female gonad development.		hp.json	positive regulation of ovary development|positive regulation of ovarian development	http://purl.obolibrary.org/obo/GO_2000196		
CL:0001065	biolink:Cell	innate lymphoid cell	A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.		hp.json		http://purl.obolibrary.org/obo/CL_0001065		
CL:0001067	biolink:Cell	group 1 innate lymphoid cell	An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines.		hp.json		http://purl.obolibrary.org/obo/CL_0001067		
CL:0001060	biolink:Cell	hematopoietic oligopotent progenitor cell, lineage-negative	A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.		hp.json		http://purl.obolibrary.org/obo/CL_0001060		
CL:0001062	biolink:Cell	effector memory CD8-positive, alpha-beta T cell, terminally differentiated	A CD8-positive, alpha beta memory T cell with the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative.		hp.json	TEMRA|CD8+ TEMRA|CD8-positive TEMRA	http://purl.obolibrary.org/obo/CL_0001062		
CL:0001061	biolink:Cell	abnormal cell	A cell found in an organism or derived from an organism exhibiting a phenotype that deviates from the expected phenotype of any native cell type of that organism. Abnormal cells are typically found in disease states or disease models.	https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12913	hp.json		http://purl.obolibrary.org/obo/CL_0001061		
CL:0001064	biolink:Cell	malignant cell	A neoplastic cell that is capable of entering a surrounding tissue	https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12917	hp.json	cancer cell	http://purl.obolibrary.org/obo/CL_0001064		
CL:0001063	biolink:Cell	neoplastic cell	An abnormal cell exhibiting dysregulation of cell proliferation or programmed cell death and capable of forming a neoplasm, an aggregate of cells in the form of a tumor mass or an excess number of abnormal cells (liquid tumor) within an organism.	https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C12922	hp.json	tumor cell|tumour cell	http://purl.obolibrary.org/obo/CL_0001063		
GO:2000194	biolink:BiologicalProcess	regulation of female gonad development	Any process that modulates the frequency, rate or extent of female gonad development.		hp.json	regulation of ovary development|regulation of ovarian development	http://purl.obolibrary.org/obo/GO_2000194		
GO:0051931	biolink:BiologicalProcess	regulation of sensory perception	Any process that modulates the frequency, rate or extent of sensory perception, the series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.		hp.json		http://purl.obolibrary.org/obo/GO_0051931		
UBERON:0011171	biolink:AnatomicalEntity	joint connecting upper and lower jaws	Synovial joint that articulates bones of upper and lower jaw.	NCIT:C32888	hp.json	jaw joint|craniomandibular joint	http://purl.obolibrary.org/obo/UBERON_0011171		
GO:0051937	biolink:BiologicalProcess	catecholamine transport	The directed movement of catecholamines, a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.		hp.json		http://purl.obolibrary.org/obo/GO_0051937		
CL:0001035	biolink:Cell	bone cell	A connective tissue cell found in bone.		hp.json		http://purl.obolibrary.org/obo/CL_0001035		
CL:0001031	biolink:Cell	cerebellar granule cell	Granule cell that is part of the cerebellum.	BTO:0004278	hp.json		http://purl.obolibrary.org/obo/CL_0001031		
CHEBI:26932	biolink:ChemicalSubstance	tetrapyrrole	A natural pigment containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.		hp.json	tetrapyrrole|a tetrapyrrole|tetrapyrroles	http://purl.obolibrary.org/obo/CHEBI_26932		3_STAR
CHEBI:26935	biolink:ChemicalSubstance	tetraterpenoid			hp.json		http://purl.obolibrary.org/obo/CHEBI_26935		
UBERON:0011160	biolink:AnatomicalEntity	nasal suture	A suture joining a nasal bone to another bone.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011160		
UBERON:0035198	biolink:AnatomicalEntity	superficial lymphatic vessel	The tubules that carry lymph throughout the body that are just beneath the surface of the skin.	FMA:52011|NCIT:C33663	hp.json	superficial lymph vessel	http://purl.obolibrary.org/obo/UBERON_0035198		
UBERON:0011164	biolink:AnatomicalEntity	neurocranium bone	A bone that is part of a neurocranium [Automatically generated definition].	MA:0001478|SCTID:120229002|EMAPA:35238	hp.json	chondrocranium bone	http://purl.obolibrary.org/obo/UBERON_0011164		
CL:0001044	biolink:Cell	effector CD4-positive, alpha-beta T cell	A CD4-positive, alpha-beta T cell with the phenotype CCR7-negative, CD45RA-positive.		hp.json	effector CD4-positive, alpha-beta T-lymphocyte|effector CD4+ T cell|effector CD4-positive, alpha-beta T-cell|effector CD4-positive, alpha-beta T lymphocyte	http://purl.obolibrary.org/obo/CL_0001044		
HP:0033480	biolink:PhenotypicFeature	Hypobilirubinemia	Decreased circulation of bilirubin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033480		
GO:1903709	biolink:BiologicalProcess	uterine gland development	The process whose specific outcome is the progression of an uterine gland over time, from its formation to the mature structure.		hp.json	glandulae uterinae development|set of uterine glands development|glandular part of endometrium development|uterine glands set development|uterine glands development|endometrial gland development|endometrium gland development	http://purl.obolibrary.org/obo/GO_1903709		
GO:0051952	biolink:BiologicalProcess	regulation of amine transport	Any process that modulates the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0051952		
GO:1903708	biolink:BiologicalProcess	positive regulation of hemopoiesis	Any process that activates or increases the frequency, rate or extent of hemopoiesis.		hp.json	positive regulation of haemopoiesis|up regulation of hematopoiesis|up-regulation of hemopoiesis|up-regulation of blood cell formation|activation of blood cell formation|up regulation of haemopoiesis|up regulation of blood cell biosynthesis|activation of hematopoiesis|positive regulation of hematopoiesis|up regulation of hemopoiesis|positive regulation of blood cell biosynthesis|activation of blood cell biosynthesis|activation of hemopoiesis|up-regulation of haemopoiesis|activation of haemopoiesis|upregulation of hematopoiesis|upregulation of blood cell formation|upregulation of blood cell biosynthesis|upregulation of hemopoiesis|positive regulation of blood cell formation|upregulation of haemopoiesis|up-regulation of hematopoiesis|up regulation of blood cell formation|up-regulation of blood cell biosynthesis	http://purl.obolibrary.org/obo/GO_1903708		
HP:0033482	biolink:PhenotypicFeature	Limited shoulder flexion	A reduced ability to flex the shoulder. Shoulder flexion is the motion that moves the arms from a resting position by the side of the body to a position above the head.		hp.json		http://purl.obolibrary.org/obo/HP_0033482		
GO:1903707	biolink:BiologicalProcess	negative regulation of hemopoiesis	Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.		hp.json	inhibition of hemopoiesis|downregulation of blood cell formation|downregulation of hemopoiesis|down regulation of blood cell formation|downregulation of haemopoiesis|down-regulation of hematopoiesis|inhibition of blood cell formation|negative regulation of hematopoiesis|down-regulation of blood cell formation|negative regulation of blood cell formation|down-regulation of blood cell biosynthesis|negative regulation of blood cell biosynthesis|down-regulation of hemopoiesis|down regulation of hematopoiesis|down regulation of haemopoiesis|down regulation of blood cell biosynthesis|inhibition of haemopoiesis|down-regulation of haemopoiesis|down regulation of hemopoiesis|negative regulation of haemopoiesis|inhibition of hematopoiesis|downregulation of hematopoiesis|inhibition of blood cell biosynthesis|downregulation of blood cell biosynthesis	http://purl.obolibrary.org/obo/GO_1903707		
HP:0033481	biolink:PhenotypicFeature	Limited lateral neck flexion	Reduced range of motion resulting in decreased ability to move the ear toward the top of the shoulder.		hp.json		http://purl.obolibrary.org/obo/HP_0033481		
GO:1903706	biolink:BiologicalProcess	regulation of hemopoiesis	Any process that modulates the frequency, rate or extent of hemopoiesis.		hp.json	regulation of blood cell formation|regulation of haemopoiesis|regulation of hematopoiesis|regulation of blood cell biosynthesis	http://purl.obolibrary.org/obo/GO_1903706		
GO:0051955	biolink:BiologicalProcess	regulation of amino acid transport	Any process that modulates the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0051955		
GO:0051956	biolink:BiologicalProcess	negative regulation of amino acid transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	down-regulation of amino acid transport|negative regulation of amino acid transmembrane transport|downregulation of amino acid transport|down regulation of amino acid transport|inhibition of amino acid transport	http://purl.obolibrary.org/obo/GO_0051956		
GO:0051953	biolink:BiologicalProcess	negative regulation of amine transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	down-regulation of amine transport|down regulation of amine transport|downregulation of amine transport|inhibition of amine transport	http://purl.obolibrary.org/obo/GO_0051953		
GO:0051954	biolink:BiologicalProcess	positive regulation of amine transport	Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amines into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	up regulation of amine transport|activation of amine transport|stimulation of amine transport|upregulation of amine transport|up-regulation of amine transport	http://purl.obolibrary.org/obo/GO_0051954		
GO:1903702	biolink:BiologicalProcess	esophagus development	The process whose specific outcome is the progression of an esophagus over time, from its formation to the mature structure.		hp.json	oesophagus development|gullet development|esophageal development	http://purl.obolibrary.org/obo/GO_1903702		
HP:0033488	biolink:PhenotypicFeature	Glomerular endocapillary leukocyte hypercellularity	Increased number of leukocytes internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries.		hp.json	Glomerular endocapillary hypercellularity consisting of leukocytes	http://purl.obolibrary.org/obo/HP_0033488		
CL:0001019	biolink:Cell	CD115-positive monocyte OR common dendritic progenitor			hp.json		http://purl.obolibrary.org/obo/CL_0001019		
GO:1903701	biolink:BiologicalProcess	substantia propria of cornea development	The process whose specific outcome is the progression of a substantia propria of cornea over time, from its formation to the mature structure.		hp.json	substantia propria development|stroma of cornea development|corneal stroma development	http://purl.obolibrary.org/obo/GO_1903701		
HP:0033487	biolink:PhenotypicFeature	Glomerular basement membranes powdery deposit	Punctate electron-dense material typically in a band-like distribution along the lamina rara interna and within tubular basement membranes within the subendothelial aspect of the glomerular basement membrane.		hp.json	Glomerular basement membranes with powdery deposit	http://purl.obolibrary.org/obo/HP_0033487		
GO:0051957	biolink:BiologicalProcess	positive regulation of amino acid transport	Any process that activates, maintains or increases the frequency, rate or extent of the directed movement of amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	upregulation of amino acid transport|up regulation of amino acid transport|stimulation of amino acid transport|up-regulation of amino acid transport|activation of amino acid transport|positive regulation of amino acid transmembrane transport	http://purl.obolibrary.org/obo/GO_0051957		
HP:0033489	biolink:PhenotypicFeature	Glomerular endocapillary neutrophil hypercellularity	Increased number of neutrophils internal to the glomerular basement membrane (GBM), but not limited to within glomerular capillaries.		hp.json		http://purl.obolibrary.org/obo/HP_0033489		
HP:0033484	biolink:PhenotypicFeature	Elevated circulating linoleylcarnitine concentration	Increased concentration of linoleylcarnitine in the blood circulation.		hp.json	Elevated plasma linoleylcarnitine, C18:2	http://purl.obolibrary.org/obo/HP_0033484		
HP:0033483	biolink:PhenotypicFeature	Podocyte infolding	Folding of cytoplasmic processes of podocytes into the glomerular basement membrane (GBM) with thickening of the lamina densa and microspheres and/or microtubular structures within the GBM.		hp.json		http://purl.obolibrary.org/obo/HP_0033483		
HP:0033486	biolink:PhenotypicFeature	Abnormal glomerular basement membrane texture	Anomalous appearance or structure of the surface of the glomerular basement membrane.		hp.json		http://purl.obolibrary.org/obo/HP_0033486		
UBERON:0035128	biolink:AnatomicalEntity	manus cartilage element		EMAPA:32631	hp.json	hand cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0035128		
HP:0033485	biolink:PhenotypicFeature	Glomerular basement membrane disruption	A point of rupture in the glomerular basement membrane (GBM) where the discontinuous portions of GBM are still identifiable with a basement membrane stain such as Periodic acid Schiff (PAS) or silver.		hp.json	Disruption of the glomerular basement membrane|Glomerular basement membrane rupture	http://purl.obolibrary.org/obo/HP_0033485		
UBERON:0035127	biolink:AnatomicalEntity	suture of hard palate	Any of the sutures of the hard palate.		hp.json	palatine suture	http://purl.obolibrary.org/obo/UBERON_0035127		
UBERON:0035119	biolink:AnatomicalEntity	diastema between incisors	A space or gap any two incisors. This may be a midline diastema between central incisors, or a diastema located entirely in a single jaw quadrant between lateral incisors.		hp.json	incisor diastema|interdental space, incisors	http://purl.obolibrary.org/obo/UBERON_0035119		
UBERON:0035118	biolink:AnatomicalEntity	material entity in digestive tract	Any material entity that is located in the digestive tract. This includes undigested food and liquid as well as unexcreted waste products. It also includes other entities such as ingested stones used to aid digestion. Any microbial cells or cell populations are also included.		hp.json	digestive tract contents|ingested material entity	http://purl.obolibrary.org/obo/UBERON_0035118		
CL:0001012	biolink:Cell	CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor			hp.json		http://purl.obolibrary.org/obo/CL_0001012		
GO:2000145	biolink:BiologicalProcess	regulation of cell motility	Any process that modulates the frequency, rate or extent of cell motility.		hp.json	regulation of cell movement|regulation of cell locomotion|regulation of movement of a cell	http://purl.obolibrary.org/obo/GO_2000145		
GO:2000146	biolink:BiologicalProcess	negative regulation of cell motility	Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility.		hp.json	negative regulation of cell locomotion|negative regulation of cell movement|negative regulation of movement of a cell	http://purl.obolibrary.org/obo/GO_2000146		
GO:0048308	biolink:BiologicalProcess	organelle inheritance	The partitioning of organelles between daughter cells at cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0048308		goslim_yeast|goslim_pir
GO:2000147	biolink:BiologicalProcess	positive regulation of cell motility	Any process that activates or increases the frequency, rate or extent of cell motility.		hp.json	positive regulation of movement of a cell|positive regulation of cell movement|positive regulation of cell locomotion	http://purl.obolibrary.org/obo/GO_2000147		
CHEBI:26907	biolink:ChemicalSubstance	tetrahydrofolic acid	A group of heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more L-glutamic acid units.		hp.json	tetrahydrofolates|tetrahydrofolic acids|tetrahydrofolate	http://purl.obolibrary.org/obo/CHEBI_26907		3_STAR
HP:0033491	biolink:PhenotypicFeature	Global mesangial sclerosis	A generalized global (over 80%) increase of mesangial matrix that is present throughout the mesangial stalk (with or without associated mesangial hypercellularity).		hp.json		http://purl.obolibrary.org/obo/HP_0033491		
GO:0051962	biolink:BiologicalProcess	positive regulation of nervous system development	Any process that activates, maintains or increases the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.		hp.json	up regulation of nervous system development|stimulation of nervous system development|up-regulation of nervous system development|activation of nervous system development|upregulation of nervous system development	http://purl.obolibrary.org/obo/GO_0051962		
NCBITaxon:10066	biolink:OrganismalEntity	Muridae		PMID:15371245|GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_10066		
HP:0033490	biolink:PhenotypicFeature	Glomerular endocapillary foam-cell hypercellularity	Presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in the glomerulus often occupying the endocapillary space.		hp.json		http://purl.obolibrary.org/obo/HP_0033490		
GO:0051963	biolink:BiologicalProcess	regulation of synapse assembly	Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.		hp.json	regulation of synapse biogenesis|regulation of synaptogenesis	http://purl.obolibrary.org/obo/GO_0051963		goslim_synapse
GO:0051960	biolink:BiologicalProcess	regulation of nervous system development	Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0051960		
HP:0033493	biolink:PhenotypicFeature	Mesangial matrix expansion	Increased mesangial extracellular material with interspace width of over 2 mesangial cell nuclei, in one or more peripheral mesangial areas.		hp.json	Increased glomerular mesangial matrix	http://purl.obolibrary.org/obo/HP_0033493		
HP:0033492	biolink:PhenotypicFeature	Podocyte cytoskeletal condensation	Reorganization of podocyte cytoskeletal proteins at the glomerular basement membrane (GBM) aspect of the cell, with associated cytoplasmic electron density at the GBM aspect of the podocyte.		hp.json		http://purl.obolibrary.org/obo/HP_0033492		
GO:0051961	biolink:BiologicalProcess	negative regulation of nervous system development	Any process that stops, prevents, or reduces the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.		hp.json	downregulation of nervous system development|down regulation of nervous system development|inhibition of nervous system development|down-regulation of nervous system development	http://purl.obolibrary.org/obo/GO_0051961		
GO:0051964	biolink:BiologicalProcess	negative regulation of synapse assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.		hp.json	negative regulation of synaptogenesis|downregulation of synapse assembly|down regulation of synapse assembly|inhibition of synapse assembly|down-regulation of synapse assembly|negative regulation of synapse biogenesis	http://purl.obolibrary.org/obo/GO_0051964		
UBERON:0035131	biolink:AnatomicalEntity	auditory ossicle cartilage element		EMAPA:35979	hp.json	ossicle cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0035131		
GO:0051965	biolink:BiologicalProcess	positive regulation of synapse assembly	Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.		hp.json	stimulation of synapse assembly|up-regulation of synapse assembly|activation of synapse assembly|positive regulation of synapse biogenesis|positive regulation of synaptogenesis|upregulation of synapse assembly|up regulation of synapse assembly	http://purl.obolibrary.org/obo/GO_0051965		
UBERON:0035130	biolink:AnatomicalEntity	auditory ossicle endochondral element			hp.json	auditory skeletal element|ossicle element of ear|ear ossicles element|middle ear skeletal element|middle ear ossicle element|ossicular chain element|ossicle element of inner ear|ossicle element|ear ossicle element	http://purl.obolibrary.org/obo/UBERON_0035130		
GO:0048318	biolink:BiologicalProcess	axial mesoderm development	The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.		hp.json		http://purl.obolibrary.org/obo/GO_0048318		
UBERON:0035133	biolink:AnatomicalEntity	longitudinal arch of pes	A curved region of the skeleton of the pes (foot) formed by the tarsal and metatarsal bones.	FMA:75030	hp.json	longitudinal arch of foot	http://purl.obolibrary.org/obo/UBERON_0035133		
HP:0033499	biolink:PhenotypicFeature	Glomerular basement membrane electron dense deposits	Electron-dense deposits in the lamina densa with a ribbon or a sausage structure.		hp.json		http://purl.obolibrary.org/obo/HP_0033499		
HP:0033498	biolink:PhenotypicFeature	Segmental glomerulosclerosis away from the vascular and tubular poles	Segmental solidification of the glomerular tuft characterized by increased extracellular matrix, causing glomerular capillary obliteration at neirhter the tubular or vascular poles. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed.		hp.json		http://purl.obolibrary.org/obo/HP_0033498		
UBERON:0035132	biolink:AnatomicalEntity	auditory ossicle pre-cartilage element		EMAPA:35982	hp.json	ossicle pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0035132		
CL:0001029	biolink:Cell	common dendritic progenitor	Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers.		hp.json	common dendritic precursor|pro-DCs|CDP	http://purl.obolibrary.org/obo/CL_0001029		
GO:0051969	biolink:BiologicalProcess	regulation of transmission of nerve impulse	Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.		hp.json	regulation of conduction of nerve impulse	http://purl.obolibrary.org/obo/GO_0051969		
HP:0033495	biolink:PhenotypicFeature	Segmental glomerulosclerosis	Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration and can include hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman capsule.		hp.json		http://purl.obolibrary.org/obo/HP_0033495		
GO:0048313	biolink:BiologicalProcess	Golgi inheritance	The partitioning of Golgi apparatus between daughter cells at cell division.		hp.json	Golgi division|Golgi partitioning	http://purl.obolibrary.org/obo/GO_0048313		
HP:0033494	biolink:PhenotypicFeature	Glomerular basement membrane amyloid spicule	Amyloid spicules are projections of typically silver-positive material from the outer aspect of the glomerular capillary wall, perpendicular to the glomerular basement membrane (GBM), most often caused by amyloidosis with the latter confirmed by additional stains.		hp.json		http://purl.obolibrary.org/obo/HP_0033494		
UBERON:0035139	biolink:AnatomicalEntity	anterior nasal spine of maxilla	A pointed projection at the front extremity of the intermaxillary suture.	FMA:75770	hp.json	anterior nasal spine|spina nasalis anterior corporis maxillae	http://purl.obolibrary.org/obo/UBERON_0035139		
GO:0120305	biolink:BiologicalProcess	regulation of pigmentation	Any process that modulates the frequency, rate or extent of the deposition or modulates the distribution of coloring matter in an organism.		hp.json		http://purl.obolibrary.org/obo/GO_0120305		
HP:0033497	biolink:PhenotypicFeature	Tip variant segmental glomerulosclerosis	Segmental solidification of the glomerular tuft characterized by an adhesion at the tip of the glomerular tuft abutting the proximal tubular taek-off can be accompanied by increased extracellular matrix, causing glomerular capillary obliteration at the glomerular tip. Features including hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells can also be observed.		hp.json	Segmental glomerulosclerosis, tip variant	http://purl.obolibrary.org/obo/HP_0033497		
HP:0033496	biolink:PhenotypicFeature	Perihilar segmental glomerulosclerosis	Segmental solidification of the glomerular tuft by increased extracellular matrix, causing glomerular capillary obliteration is present at the vascular pole, involving less than 50% of the tuft. It can be accompanied by other descriptors such as hyalinosis, foam cells, hypertrophy of overlying glomerular epithelial cells, podocyte depletion, halo and adhesion of the tuft to the Bowman's capsule.		hp.json	Segmental glomerulosclerosis, perihilar pattern	http://purl.obolibrary.org/obo/HP_0033496		
CL:0001022	biolink:Cell	CD115-positive monocyte	CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive.		hp.json		http://purl.obolibrary.org/obo/CL_0001022		
CL:0001021	biolink:Cell	CD34-positive, CD38-positive common lymphoid progenitor	A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive.		hp.json	CD10-positive common lymphocyte progenitor|CD10-positive common lymphoid precursor|CD10-positive common lymphocyte precursor	http://purl.obolibrary.org/obo/CL_0001021		
UBERON:0035129	biolink:AnatomicalEntity	pes cartilage element		EMAPA:32657	hp.json	foot cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0035129		
CL:0001024	biolink:Cell	CD34-positive, CD38-negative hematopoietic stem cell	CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.	CALOHA:TS-0448|FMA:86475	hp.json	CD133-positive hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0001024		
GO:2000155	biolink:BiologicalProcess	positive regulation of cilium-dependent cell motility	Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility.		hp.json	positive regulation of ciliary cell motility	http://purl.obolibrary.org/obo/GO_2000155		
CL:0001026	biolink:Cell	CD34-positive, CD38-positive common myeloid progenitor	A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative.		hp.json	CD71-positive common myeloid precursor	http://purl.obolibrary.org/obo/CL_0001026		
CL:0001028	biolink:Cell	CD7-positive lymphoid progenitor cell	CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative.		hp.json	CD7-positive lymphoid precursor	http://purl.obolibrary.org/obo/CL_0001028		
CL:0001027	biolink:Cell	CD7-negative lymphoid progenitor cell	CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative.		hp.json	CD7-negative lymphoid precursor	http://purl.obolibrary.org/obo/CL_0001027		
GO:0048319	biolink:BiologicalProcess	axial mesoderm morphogenesis	The process in which the anatomical structures of the axial mesoderm are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0048319		
GO:0048320	biolink:BiologicalProcess	axial mesoderm formation	The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.		hp.json		http://purl.obolibrary.org/obo/GO_0048320		
GO:0051971	biolink:BiologicalProcess	positive regulation of transmission of nerve impulse	Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.		hp.json	up-regulation of transmission of nerve impulse|positive regulation of conduction of nerve impulse|up regulation of transmission of nerve impulse|activation of transmission of nerve impulse|stimulation of transmission of nerve impulse|upregulation of transmission of nerve impulse	http://purl.obolibrary.org/obo/GO_0051971		
GO:1903729	biolink:BiologicalProcess	regulation of plasma membrane organization	Any process that modulates the frequency, rate or extent of plasma membrane organization.		hp.json	regulation of plasma membrane organization and biogenesis|regulation of plasma membrane organisation	http://purl.obolibrary.org/obo/GO_1903729		
PR:P05186	biolink:Protein	alkaline phosphatase, tissue-nonspecific isozyme (human)	An alkaline phosphatase, tissue-nonspecific isozyme that is encoded in the genome of human.	UniProtKB:P05186	hp.json	phosphoamidase (human)|TNS-ALP (human)|hALPL|phosphocreatine phosphatase (human)|ALPL|TNSALP (human)|alkaline phosphatase liver/bone/kidney isozyme (human)|AP-TNAP (human)	http://purl.obolibrary.org/obo/PR_P05186		
GO:0061303	biolink:BiologicalProcess	cornea development in camera-type eye	The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.		hp.json		http://purl.obolibrary.org/obo/GO_0061303		
GO:0061304	biolink:BiologicalProcess	retinal blood vessel morphogenesis	The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0061304		
GO:0061307	biolink:BiologicalProcess	cardiac neural crest cell differentiation involved in heart development	The process in which a relatively unspecialized cell acquires specialized features of a cardiac neural crest cell that will migrate to the heart and contribute to its development. Cardiac neural crest cells are specialized cells that migrate toward the heart from the third, fourth and sixth pharyngeal arches.		hp.json		http://purl.obolibrary.org/obo/GO_0061307		
GO:0061308	biolink:BiologicalProcess	cardiac neural crest cell development involved in heart development	The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0061308		
GO:0061309	biolink:BiologicalProcess	cardiac neural crest cell development involved in outflow tract morphogenesis	The process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the shaping of the outflow tract.		hp.json		http://purl.obolibrary.org/obo/GO_0061309		
PR:P05187	biolink:Protein	alkaline phosphatase, placental type (human)	An alkaline phosphatase, placental type that is encoded in the genome of human.	UniProtKB:P05187	hp.json	hALPP|PLAP-1 (human)|ALPP|PLAP|alkaline phosphatase Regan isozyme (human)|placental alkaline phosphatase 1 (human)	http://purl.obolibrary.org/obo/PR_P05187		
GO:0051970	biolink:BiologicalProcess	negative regulation of transmission of nerve impulse	Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.		hp.json	downregulation of transmission of nerve impulse|inhibition of transmission of nerve impulse|negative regulation of conduction of nerve impulse|down-regulation of transmission of nerve impulse|down regulation of transmission of nerve impulse	http://purl.obolibrary.org/obo/GO_0051970		
GO:0051984	biolink:BiologicalProcess	positive regulation of chromosome segregation	Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.		hp.json	upregulation of chromosome segregation|up regulation of chromosome segregation|stimulation of chromosome segregation|up-regulation of chromosome segregation|activation of chromosome segregation	http://purl.obolibrary.org/obo/GO_0051984		
GO:0048332	biolink:BiologicalProcess	mesoderm morphogenesis	The process in which the anatomical structures of the mesoderm are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0048332		
GO:0051985	biolink:BiologicalProcess	negative regulation of chromosome segregation	Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.		hp.json	down regulation of chromosome segregation|inhibition of chromosome segregation|down-regulation of chromosome segregation|downregulation of chromosome segregation	http://purl.obolibrary.org/obo/GO_0051985		
GO:0051983	biolink:BiologicalProcess	regulation of chromosome segregation	Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.		hp.json		http://purl.obolibrary.org/obo/GO_0051983		
CL:0001008	biolink:Cell	Kit and Sca1-positive hematopoietic stem cell	A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative.		hp.json	LSK stem cell|Sca1-positive hematopoietic stem cell	http://purl.obolibrary.org/obo/CL_0001008		
GO:0048339	biolink:BiologicalProcess	paraxial mesoderm development	The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.		hp.json		http://purl.obolibrary.org/obo/GO_0048339		
UBERON:0035159	biolink:AnatomicalEntity	entire surface of organism	Anatomical surface, which is the external surface of the whole body. Examples: There is only one body surface.	SCTID:261060002|NCIT:C29667|FMA:61695|UMLS:C0489451	hp.json	surface of body	http://purl.obolibrary.org/obo/UBERON_0035159		
GO:0048333	biolink:BiologicalProcess	mesodermal cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.		hp.json	mesoderm cell differentiation	http://purl.obolibrary.org/obo/GO_0048333		
GO:2000173	biolink:BiologicalProcess	negative regulation of branching morphogenesis of a nerve	Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve.		hp.json		http://purl.obolibrary.org/obo/GO_2000173		
GO:2000174	biolink:BiologicalProcess	regulation of pro-T cell differentiation	Any process that modulates the frequency, rate or extent of pro-T cell differentiation.		hp.json	regulation of pro-T lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_2000174		
GO:2000175	biolink:BiologicalProcess	negative regulation of pro-T cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation.		hp.json	negative regulation of pro-T lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_2000175		
GO:2000176	biolink:BiologicalProcess	positive regulation of pro-T cell differentiation	Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation.		hp.json	positive regulation of pro-T lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_2000176		
GO:2000177	biolink:BiologicalProcess	regulation of neural precursor cell proliferation	Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_2000177		
GO:2000178	biolink:BiologicalProcess	negative regulation of neural precursor cell proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_2000178		
GO:2000179	biolink:BiologicalProcess	positive regulation of neural precursor cell proliferation	Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_2000179		
GO:2000172	biolink:BiologicalProcess	regulation of branching morphogenesis of a nerve	Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve.		hp.json		http://purl.obolibrary.org/obo/GO_2000172		
HP:0006060	biolink:PhenotypicFeature	Tombstone-shaped proximal phalanges		UMLS:C1862420	hp.json	Tombstone-shaped innermost digital bones	http://purl.obolibrary.org/obo/HP_0006060		
HP:0033680	biolink:PhenotypicFeature	Pilocytic astrocytoma	The most common form of astrocytoma (WHO Grade I) in childhood. These typically have MAPK signalling pathway abnormalities.	NCIT:C4047	hp.json		http://purl.obolibrary.org/obo/HP_0033680		
HP:0033686	biolink:PhenotypicFeature	Mitochondrial hypertrophy	Enlargment of mitochondria. Mitochondrial hypertrophy is not discernible by light microscopy. By electron microscopy (EM), hypertrophic mitochondria have normal cristae and normal matrix density. In contrast, swollen mitochondria display swollen cristae and irregular matrix densities in EM.		hp.json	Megamitochondria	http://purl.obolibrary.org/obo/HP_0033686		
HP:0031023	biolink:PhenotypicFeature	Multiple mucosal neuromas	Multiple painful, dome-shaped, translucent pink to skin-colored papules on oral mucosa. Histologically, the lesions may demonstrate dermal proliferation of well-demarcated nerve bundles associated with abundant mucin and surrounded by a distinct perineural sheath.	NCIT:C6559	hp.json		http://purl.obolibrary.org/obo/HP_0031023		
HP:0033685	biolink:PhenotypicFeature	Fiber type grouping	An abnormal distribution of muscle fiber types in muscle tissue. Human skeletal muscle contains at least two fiber types recognizable by histochemical techniques. In transverse sections of normal skeletal muscle, type 1 and type 2 fibers are distributed in a random fashion. Grouping of fibers of the same type can be seen in certain peripheral neuropathies, thought to be due to reinnervation of denervated muscle fibers by sprouting axons. With grouping, motor units enlarge. The fibers of a motor unit, which are normally scattered, come to lie adjacent to one another. Histochemical examination shows groups of muscle fibers of the same histochemical type.		hp.json	Fibre type grouping	http://purl.obolibrary.org/obo/HP_0033685		
HP:0031024	biolink:PhenotypicFeature	Cylindroma	A benign skin adnexal tumor of eccrine differentiation.		hp.json		http://purl.obolibrary.org/obo/HP_0031024		
HP:0033688	biolink:PhenotypicFeature	Long term memory impairment	A deficit in the ability to retrieve information from long-term memory, which can be defined as a seemingly unlimited capacity to store memories can last years and relate to the performance of actions or skills (i.e., procedural memories, knowing how) and memories of facts, rules, concepts, and events (i.e., declarative memories, knowing that).		hp.json	Long term memory loss	http://purl.obolibrary.org/obo/HP_0033688		
HP:0031025	biolink:PhenotypicFeature	Gastric leiomyosarcoma	A malignant neoplasm of the stomach that grows submucosally in the gastric wall. Necrosis and hemorrhage may be visible radiologically. Histologically, spindle cells with abnormal mitotic activity may be visible.		hp.json		http://purl.obolibrary.org/obo/HP_0031025		
HP:0031026	biolink:PhenotypicFeature	Snail-like ilia	The ilia is round and hypoplastic with a very flat acetabular roof and a very unusual medial projection of bone that is said to resemble the head of a snail. Figure 4 of PMID:3799723 illustrates this feature.		hp.json	Schneckenbecken dysplasia|Snail-like pelvis|Snail-shaped ilia	http://purl.obolibrary.org/obo/HP_0031026		
HP:0033687	biolink:PhenotypicFeature	Short term memory impairment	A deficit in the retention of pieces of information (memory chunks) for a relatively short time (usually up to 30 seconds).		hp.json	Short term memory loss	http://purl.obolibrary.org/obo/HP_0033687		
HP:0033682	biolink:PhenotypicFeature	Pleomorphic xanthoastrocytoma	Pleomorphic xanthoastrocytomas (PXA) are rare low-grade astrocytomas (WHO Grade II) typically found in the temporal lobe and classically presenting with epilepsy. PXA is an astrocytic neoplasm that most often presents in children or young adults but can also occur in adults. The diagnosis of anaplastic PXA is made based upon tumor histopathologic characteristics and requires increased proliferative activity (mitotic index at least 5 mitoses/10 HPF), which is associated with worse overall survival. In general, anaplastic PXAs acquire features of a more aggressive astrocytic neoplasm that can include increased proliferation, necrosis, microvascular proliferation, loss of pericellular reticulin, and increased infiltrative growth.		hp.json		http://purl.obolibrary.org/obo/HP_0033682		
HP:0033681	biolink:PhenotypicFeature	Oligodendroglioma	Oligodendroglioma is a type of diffusely infiltrating glioma and constitutes approximately 5% of primary intracranial tumors. They often involve the cortical gray matter and are most commonly seen in the frontal lobes. OGs are generally low grade WHO grade II neoplasms that are slow-growing tumors and have a favorable treatment response when compared to other gliomas. Grade III anaplastic OG is a more malignant form of the tumor which portends a less favorable prognosis and may occur de novo or as degeneration from the lower grade OG.	NCIT:C3288	hp.json		http://purl.obolibrary.org/obo/HP_0033681		
HP:0031020	biolink:PhenotypicFeature	Bone marrow hypercellularity	A larger than normal amount or percentage of hematopoietic cells relative to marrow fat.		hp.json		http://purl.obolibrary.org/obo/HP_0031020		
HP:0033684	biolink:PhenotypicFeature	Abnormal muscle fiber-type distribution	Ay deviation from the normal distribution of fiber types in skeletal muscle. The skeletal muscle groups of the mammalian body are made up of bundles of muscle fibers. These fibers can be assigned to different Types, with characteristic movement rates, response to neural inputs, and metabolic styles. Skeletal muscle fibers are broadly classified as slow-twitch (type 1) and fast-twitch (type 2). Multiple fiber types are generally intermingled within a single muscle group, and different muscle groups have varying proportions of fiber types		hp.json		http://purl.obolibrary.org/obo/HP_0033684		
HP:0031021	biolink:PhenotypicFeature	Squamous Papilloma	A benign epithelial neoplasm characterized by a papillary growth pattern and a proliferation of neoplastic squamous cells without morphologic evidence of malignancy [NCI thesaurus].	NCIT:C3712	hp.json		http://purl.obolibrary.org/obo/HP_0031021		
UBERON:0011234	biolink:AnatomicalEntity	fibrous membrane of synovial tendon sheath		FMA:40877	hp.json		http://purl.obolibrary.org/obo/UBERON_0011234		
UBERON:0011233	biolink:AnatomicalEntity	synovial membrane of synovial tendon sheath	Synovial sac which surrounds parts of one or more tendons. Examples: synovial tendon sheath of manual digit 2, radial bursa.	FMA:40878|Wikipedia:Synovial_sheath|BTO:0001823	hp.json	synovium	http://purl.obolibrary.org/obo/UBERON_0011233		
HP:0033683	biolink:PhenotypicFeature	Jaw hyperreflexia	Increased intensity of muscle tendon reflexes in jaw.		hp.json	Brisk jaw jerk	http://purl.obolibrary.org/obo/HP_0033683		
HP:0031022	biolink:PhenotypicFeature	Oropharyngeal squamous papilloma	A benign exophytic neoplasm that arises from the oropharynx. It is characterized by the presence of a connective tissue core covered by stratified squamous epithelium [NCI thesaurus].	NCIT:C6038	hp.json	Squamous papilloma of the uvula	http://purl.obolibrary.org/obo/HP_0031022		
GO:0120178	biolink:NamedThing	steroid hormone biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0120178		
HP:0031027	biolink:PhenotypicFeature	Internal notch of the femoral head	A small V-shaped indentation on the internal aspect of the femoral head. This feature is well illustrated in Figure 5 of PMID:11694546.		hp.json		http://purl.obolibrary.org/obo/HP_0031027		
HP:0031028	biolink:PhenotypicFeature	Lactescent serum	Serum sample with a grossly white (milk-like, i.e., lactescent) appearance. This feature is indicative of an extremely elevated serum triglyceride level.		hp.json	Milk-like serum|Plasma lactescence	http://purl.obolibrary.org/obo/HP_0031028		
HP:0033689	biolink:PhenotypicFeature	Anterograde memory impairment	The impaired ability to establish new long-term memories.		hp.json	Anterograde amnesia	http://purl.obolibrary.org/obo/HP_0033689		
HP:0031029	biolink:PhenotypicFeature	Elevated carcinoembryonic antigen level	An increased blood concentration of the carcinoembryonic antigen (CEA). CEA is a member of the immunoglobulin supergene family. The human CEA gene family is clustered on chromosome 19q and comprises 29 genes. CEA is highly expressed in embryonic tissue and in some cancers, and is a widely used tumor marker.		hp.json	Increased plasma CEA	http://purl.obolibrary.org/obo/HP_0031029		
HP:0006059	biolink:PhenotypicFeature	Cone-shaped metacarpal epiphyses	A cone-shaped appearance of the epiphyses of the metacarpal bones, producing a 'ball-in-a-socket' appearance. This epiphyses are located at the distal ends of the metacarpal bones.	UMLS:C1855239	hp.json	Metacarpal cone-shaped epiphyses|Cone-shaped end part of long bone	http://purl.obolibrary.org/obo/HP_0006059		
HP:0006055	biolink:PhenotypicFeature	Ulnar deviated club hands		UMLS:C1833881	hp.json		http://purl.obolibrary.org/obo/HP_0006055		
HP:0006070	biolink:PhenotypicFeature	Metacarpophalangeal joint contracture	A chronic loss of joint motion in metacarpophalangeal joints due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement.	UMLS:C2677209	hp.json	Metacarpal/phalangeal joint contractures	http://purl.obolibrary.org/obo/HP_0006070		
PR:000001839	biolink:Protein	T-cell surface glycoprotein CD5	A protein that is a translation product of the human CD5 gene or a 1:1 ortholog thereof.	PANTHER:PTHR19331:SF6	hp.json	CD5|lymphocyte antigen T1/Leu-1|ly-1|lymphocyte antigen 1|LEU1|Lyt-1	http://purl.obolibrary.org/obo/PR_000001839		
HP:0033691	biolink:PhenotypicFeature	Procedural memory loss	A reduction in the ability to retrieve information about how to perform activities, such as how to ride a bike or drive a car, how to perform activities of daily living, or how to play a musical instrument.		hp.json	Impaired procedural memory|Procedural memory deficit	http://purl.obolibrary.org/obo/HP_0033691		
HP:0033690	biolink:PhenotypicFeature	Retrograde memory impairment	Inability to retrieve information from the long-term memory that was acquired before the onset of amnesia.		hp.json	Retrograde amnesia	http://purl.obolibrary.org/obo/HP_0033690		
UBERON:0001899	biolink:AnatomicalEntity	epithalamus	Most dorsal part of the thalamus, comprising the pineal gland and habenular nuclei in most vertebrates. In a few vertebrates, it also includes the parietal eye. (Butler and Hodos, Comparative Vertebrate Neuroanatomy, 2nd ed, 2005, pg. 345-346.	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=292|DHBA:10451|MAT:0000422|ZFA:0000509|BAMS:EPI|BAMS:Epi|EHDAA:5433|MA:0000172|MIAA:0000422|TAO:0000509|UMLS:C0152361|EV:0100220|UMLS:C0152361|CALOHA:TS-2060|AAO:0010482|BAMS:ETh|EFO:0000918|BAMS:EpT|BIRNLEX:1710|BM:Die-Epi|BTO:0000175|VHOG:0000178|HBA:4520|OpenCyc:Mx4rvneLQpwpEbGdrcN5Y29ycA|EHDAA2:0000448|GAID:455|EMAPA:17532|MBA:958|PBA:128013147|FMA:62009|NCIT:C12457|MESH:D019261	hp.json	epithalamus|ETh	http://purl.obolibrary.org/obo/UBERON_0001899		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0001898	biolink:AnatomicalEntity	hypothalamus	A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia].	BIRNLEX:734|EHDAA:5446|ZFA:0000032|GAID:460|galen:Hypothalamus|MAT:0000112|MA:0000173|TAO:0000032|AAO:0010484|BAMS:HY|BAMS:Hy|CALOHA:TS-0469|MIAA:0000112|UMLS:C0020663|VHOG:0000179|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=292|EMAPA:17536|EHDAA2:0000802|XAO:0004070|HBA:4540|UMLS:C0020663|DHBA:10467|MESH:D007031|BM:Die-Hy|NCIT:C12458|BTO:0000614|EFO:0000107|FMA:62008|OpenCyc:Mx4rwEgr9JwpEbGdrcN5Y29ycA|EV:0100225|MBA:1097	hp.json	preoptico-hypothalamic region|hypothalamus|preoptico-hypothalamic area|Hy	http://purl.obolibrary.org/obo/UBERON_0001898		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|vertebrate_core
HP:0031034	biolink:PhenotypicFeature	Abnormal insulin like growth factor binding protein acid labile subunit level	A deviation from the normal blood concentration of the insulin like growth factor binding protein acid labile subunit (IGFALS; Entrez Gene ID 3483). The acid-labile subunit (IGFALS) acts in the insulin-like growth (IGF) system by binding circulating IGF1 in a ternary complex with binding protein (IGFBP)-3 to prevent IGF1 from crossing the endothelial barrier.		hp.json		http://purl.obolibrary.org/obo/HP_0031034		
HP:0033697	biolink:PhenotypicFeature	Vesicular eruption	A type of acute-onset skin rash characterized by multiple vesicles, which are circumscribed, fluid-containing, epidermal elevation generally considered less than 10mm in diameter at the widest point. The fluid contained in a vesicle may be clear, serous, or hemorrhagic.		hp.json		http://purl.obolibrary.org/obo/HP_0033697		
HP:0033696	biolink:PhenotypicFeature	Pseudo-chilblain	Acral areas of erythema with vesicles or pustules. The lesions resemble chilblains and have purpuric areas, affecting hands and feet.		hp.json	Chilblain-like lesion	http://purl.obolibrary.org/obo/HP_0033696		
UBERON:0011220	biolink:AnatomicalEntity	mastoid process of temporal bone	The mastoid process is a conical prominence projecting from the undersurface of the mastoid portion of the temporal bone. It is located just behind the external acoustic meatus, and lateral to the styloid process. Its size and form vary somewhat; it is larger in the male than in the female. This process serves for the attachment of the posterior belly of the digastric, sternocleidomastoid, splenius capitis, and longissimus capitis muscles. The word is derived from the Greek 'masto-', alluding to its resemblance to the breast.	FMA:52872|UMLS:C0446908|NCIT:C12503	hp.json	mastoid|mastoid process|processus mastoideus ossis temporalis|mastoid process of skull	http://purl.obolibrary.org/obo/UBERON_0011220		pheno_slim
HP:0031035	biolink:PhenotypicFeature	Chronic infection	Presence of a protracted or persistent infection by a pathogen potentially related to an underlying abnormality of the immune system that is not able to clear the infection.		hp.json		http://purl.obolibrary.org/obo/HP_0031035		
HP:0033699	biolink:PhenotypicFeature	Polymorphic vesicular eruption	A type of vesicular eruption in which the vesicles are at different stages.		hp.json		http://purl.obolibrary.org/obo/HP_0033699		
HP:0031036	biolink:PhenotypicFeature	Reduced growth-hormone binding protein level	A decreased blood concentration of growth hormone binding protein.		hp.json	Decreased plasma GH-binding protein	http://purl.obolibrary.org/obo/HP_0031036		
HP:0033698	biolink:PhenotypicFeature	Monomorphic vesicular eruption	A type of vesicular eruption in which the vesicles are at same stages.		hp.json		http://purl.obolibrary.org/obo/HP_0033698		
HP:0031037	biolink:PhenotypicFeature	Reduced insulin-like factor 3 level	Blood concentration of insulin-like factor 3 (ILF3) is below normal limits.		hp.json	Reduced plasma INSL3 level	http://purl.obolibrary.org/obo/HP_0031037		
HP:0033693	biolink:PhenotypicFeature	Phantosmia	Perception of an odor in the absence of any stimuli in the surrounding environment that could emit the odor.		hp.json	Phantom odor|Phantom smell|Olfactory hallucination|Phantom odour	http://purl.obolibrary.org/obo/HP_0033693		
HP:0031030	biolink:PhenotypicFeature	Elevated carcinoma antigen 125 level	An increased blood concentration of carcinoma antigen 125 (CA-125). CA-125, also known as mucin 16, can exhibit increased blood levels in certain types of cancer.		hp.json	Increased plasma CA125	http://purl.obolibrary.org/obo/HP_0031030		
HP:0033692	biolink:PhenotypicFeature	Declarative memory loss	Impaired ability to remember facts and events.		hp.json	Impaired declarative memory	http://purl.obolibrary.org/obo/HP_0033692		
HP:0031031	biolink:PhenotypicFeature	Abnormal retinol-binding protein level	A deviation from normal blood concentration of retinol-binding protein (RBP). The most commonly used indicator of vitamin A status is the serum retinol concentration (retinol is one of the several compounds known as vitamin A). The serum RBP concentration is used as a surrogate measure for serum retinol.		hp.json		http://purl.obolibrary.org/obo/HP_0031031		
HP:0033695	biolink:PhenotypicFeature	Occupational disability	This is a general term that denotes a reduced ability to perform the work that one performed prior to an illness, and may be related to pain, cognitive dysfunction, fatigue or other physical disabilities.		hp.json		http://purl.obolibrary.org/obo/HP_0033695		
HP:0031032	biolink:PhenotypicFeature	Decreased retinol-binding protein level	A reduced blood concentration of retinol-binding protein. This finding predicts vitamin A deficiency with high sensitivity and specificity.		hp.json		http://purl.obolibrary.org/obo/HP_0031032		
UBERON:0011222	biolink:AnatomicalEntity	intra-ocular muscle		EMAPA:18808|FMA:49150|AAO:0010038	hp.json	intrinsic muscle of eyeball|intrinsic ocular muscle	http://purl.obolibrary.org/obo/UBERON_0011222		
HP:0033694	biolink:PhenotypicFeature	Tactile hallucination	The false perception of tactile sensory input that creates a hallucinatory sensation of physical contact with an imaginary object.		hp.json	Tactile hallucinations	http://purl.obolibrary.org/obo/HP_0033694		
HP:0031033	biolink:PhenotypicFeature	Impaired urinary acidification	The kidney contributes towards acid-base homeostasis by excreting H+ ions and retaining bicarbonate. This process is known as acidification of the urine. The pH of urine ranges normally from 4.5 to 8. The inability to reduce the pH of the urine in a situation where it would be otherwise expected is known as an acidification defect.		hp.json	Renal acidification defect	http://purl.obolibrary.org/obo/HP_0031033		
CHEBI:36237	biolink:ChemicalSubstance	cholanic acid	A steroid acid that consists of cholane having a carboxy group in place of the methyl group at position 24.	Reaxys:13246008|Patent:JP2008069152|CAS:25312-65-6	hp.json	cholan-24-oic acid	http://purl.obolibrary.org/obo/CHEBI_36237		3_STAR
UBERON:0011216	biolink:AnatomicalEntity	organ system subdivision	A subdivision of an anatomical system.	FMA:67509|SCTID:91690000|FBbt:00007330	hp.json		http://purl.obolibrary.org/obo/UBERON_0011216		upper_level
UBERON:0011215	biolink:AnatomicalEntity	central nervous system cell part cluster	A multi cell part structure that is part of a central nervous system.	FMA:83143	hp.json	cell part cluster of neuraxis|neuraxis layer	http://purl.obolibrary.org/obo/UBERON_0011215		upper_level
HP:0031038	biolink:PhenotypicFeature	Spermatogenesis maturation arrest	Maturation arrest (MA) is defined as germ cells that fail to complete maturation. Uniform MA is characterized by spermatogenic arrest at the same stage of spermatogenesis throughout the seminiferous tubules. MA is subcategorized into early MA, in which only spermatogonia or spermatocytes are found, and late MA, in which spermatids are detected without spermatozoa.		hp.json	Meiotic maturation arrest of spermatogenesis	http://purl.obolibrary.org/obo/HP_0031038		
HP:0031039	biolink:PhenotypicFeature	Early spermatogenesis maturation arrest	A type of maturation arrest in which only spermatogonia or spermatocytes are found.		hp.json	Spermatocytic arrest	http://purl.obolibrary.org/obo/HP_0031039		
GO:0120186	biolink:BiologicalProcess	negative regulation of protein localization to chromatin	Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to chromatin.		hp.json	negative regulation of protein localisation to chromatin	http://purl.obolibrary.org/obo/GO_0120186		
CHEBI:36238	biolink:ChemicalSubstance	5beta-cholanic acid		Beilstein:3214794|LIPID_MAPS_instance:LMST04010441|CAS:546-18-9	hp.json	5beta-cholanoic acid|ursocholanic acid|(5beta,17beta)-gamma-methylandrostane-17-butanoic acid|5beta-cholan-24-oic acid|(5beta)-cholan-24-oic acid|5beta-cholanic acid	http://purl.obolibrary.org/obo/CHEBI_36238		3_STAR
GO:0120187	biolink:BiologicalProcess	positive regulation of protein localization to chromatin	Any process that activates or increases the frequency, rate or extent of protein localization to chromatin.		hp.json	positive regulation of protein localisation to chromatin	http://purl.obolibrary.org/obo/GO_0120187		
HP:0006067	biolink:PhenotypicFeature	Multiple carpal ossification centers	A delay in the process of formation and maturation of the epiphysis of one or more long bones.	UMLS:C1835573	hp.json	Multiple carpal ossification centres	http://purl.obolibrary.org/obo/HP_0006067		
HP:0006069	biolink:PhenotypicFeature	obsolete Severe carpal ossification delay			hp.json		http://purl.obolibrary.org/obo/HP_0006069		
PR:000001833	biolink:Protein	SLAM family member 1	A protein that is a translation product of the human SLAMF1 gene or a 1:1 ortholog thereof.	PANTHER:PTHR12080:SF1	hp.json	SLAMF1|IPO-3|CD150|SLAM|CDw150	http://purl.obolibrary.org/obo/PR_000001833		
PR:000001836	biolink:Protein	CD7 molecule	A protein that is a translation product of the human CD7 gene or a 1:1 ortholog thereof.	PIRSF:PIRSF038791	hp.json	T-cell leukemia antigen|T-cell antigen CD7|T-cell surface antigen Leu-9|TP41|CD7|GP40	http://purl.obolibrary.org/obo/PR_000001836		
CHEBI:36233	biolink:ChemicalSubstance	disaccharide	A compound in which two monosaccharides are joined by a glycosidic bond.	KEGG:C01911	hp.json	disaccharides|Disaccharide|Disacharid|disacarido|disacaridos|Disaccharid	http://purl.obolibrary.org/obo/CHEBI_36233		3_STAR
HP:0006064	biolink:PhenotypicFeature	Limited interphalangeal movement		UMLS:C1840089	hp.json	Limited movement of hinge joints	http://purl.obolibrary.org/obo/HP_0006064		
PR:000001809	biolink:Protein	CD59-like glycoprotein	A protein that is a translation product of the human CD59 gene, a 1:1 ortholog thereof, or pro-orthologs thereof.	PIRSF:PIRSF038782	hp.json	CD59-like	http://purl.obolibrary.org/obo/PR_000001809		
HP:0031040	biolink:PhenotypicFeature	Late spermatogenesis maturation arrest	A type of maturation arrest in which spermatids are detected without spermatozoa.		hp.json	Maturation arrest of spermatogenesis at spermatid stage	http://purl.obolibrary.org/obo/HP_0031040		
HP:0006040	biolink:PhenotypicFeature	Long second metacarpal		UMLS:C1861531	hp.json	Long 2nd long bone of hand	http://purl.obolibrary.org/obo/HP_0006040		
UBERON:0001887	biolink:AnatomicalEntity	internal capsule of telencephalon	White matter regional part of brain which is flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the cerebral cortex and the brainstem and spinal cord. It consists of three distinct parts: an anterior limb, posterior limb, and genu. (Adapted from MSH by Maryann Martone).	UMLS:C0152341|MESH:D020772|BAMS:int|FMA:61950|HBA:9263|PBA:10102|BM:IC|DMBA:17770|MBA:6|DHBA:10581|BIRNLEX:1659|EMAPA:35437|UMLS:C0152341|MA:0002748|EMAPA:18206|NCIT:C13082|BAMS:ic|GAID:685	hp.json	internal capsule|internal capsule radiations|brain internal capsule|capsula interna	http://purl.obolibrary.org/obo/UBERON_0001887		pheno_slim|uberon_slim
UBERON:0001889	biolink:AnatomicalEntity	trunk of phrenic nerve		FMA:6198|MA:0001177|EHDAA2:0001463|EMAPA:37718	hp.json	phrenic nerve trunk|phrenic neural trunk	http://purl.obolibrary.org/obo/UBERON_0001889		
HP:0031045	biolink:PhenotypicFeature	Acral blistering	Bullae (defined as fluid-filled blisters more than 5 mm in diameter with thin walls) of the skin with an acral distribution (affecting peripheral regions such as hands and feet).		hp.json		http://purl.obolibrary.org/obo/HP_0031045		
HP:0031046	biolink:PhenotypicFeature	Absent soft palate	A developmental defect characterized by lack of a soft palate.		hp.json	Agenesis of the soft palate	http://purl.obolibrary.org/obo/HP_0031046		
NCBITaxon:131221	biolink:OrganismalEntity	Streptophytina		GC_ID:1	hp.json	Charophyta/Embryophyta group|charophyte/embryophyte group	http://purl.obolibrary.org/obo/NCBITaxon_131221		
HP:0031047	biolink:PhenotypicFeature	Paraproteinemia	An abnormal immunoglobulin or part of an Ig (light chain) in the circulation. Paraproteins are typically produced by a clonal population of B-cell derived plasma cells.		hp.json	Monoclonal hypergammaglobulinemia	http://purl.obolibrary.org/obo/HP_0031047		
HP:0031048	biolink:PhenotypicFeature	Light-chain paraproteinemia	An abnormal immunoglobulin light chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.		hp.json		http://purl.obolibrary.org/obo/HP_0031048		
HP:0031041	biolink:PhenotypicFeature	Obstruction of the superior vena cava	Blockage of blood flow through the superior vena cava (SVC). Because the venous drainage from the upper extremities, upper thorax and head is obstructed, SVC obstruction presents with symptoms related to engorgement of these areas. Both the degree of SVC compromise and the extent of collateral veins determine the varied clinical presentation, which can be as mild as slight facial and upper extremity edema or as dire as intracranial swelling, seizures, hemodynamic instability and tracheal obstruction.		hp.json	Superior vena cava obstruction|Superior vena cava syndrome	http://purl.obolibrary.org/obo/HP_0031041		
HP:0031042	biolink:PhenotypicFeature	Strawberry tongue	Inflammed tongue with hyperplastic (enlarged) fungiform papillae that is said to resemble a strawberry or raspberry.		hp.json	Raspberry tongue	http://purl.obolibrary.org/obo/HP_0031042		
HP:0031043	biolink:PhenotypicFeature	Type A4 brachydactyly	A type of brachydactyly characterized by brachymesophalangy affecting mainly the 2nd and 5th digits.		hp.json		http://purl.obolibrary.org/obo/HP_0031043		
HP:0031044	biolink:PhenotypicFeature	Type A5 brachydactyly	A type of brachydactyly characterized by absent middle phalanges of digits 2 to 5.		hp.json		http://purl.obolibrary.org/obo/HP_0031044		
HP:0031049	biolink:PhenotypicFeature	Heavy-chain paraproteinemia	An abnormal immunoglobulin heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.		hp.json		http://purl.obolibrary.org/obo/HP_0031049		
CHEBI:38867	biolink:ChemicalSubstance	anaesthetic	Substance which produces loss of feeling or sensation.		hp.json	anaesthetics|anaesthetic|Anaesthetikum|anesthetic agent|anesthetics|Anaesthetika|anesthetic drug	http://purl.obolibrary.org/obo/CHEBI_38867		3_STAR
UBERON:0001895	biolink:AnatomicalEntity	metencephalon	Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified].	MA:0000197|EHDAA:5498|BAMS:Met|HBA:4833|FMA:62003|Wikipedia:Metencephalon|BTO:0000673|VHOG:0000741|EMAPA:17071|CALOHA:TS-2029|DHBA:10655|UMLS:C1516904|UMLS:C0376353|EHDAA2:0001149|NCIT:C32741|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=543|GAID:594|BIRNLEX:965|MESH:D020540	hp.json	epencephalon|epencephalon-2	http://purl.obolibrary.org/obo/UBERON_0001895		pheno_slim|uberon_slim
HP:0008697	biolink:PhenotypicFeature	Hypoplasia of the fallopian tube	Developmental hypoplasia of the fallopian tube.	UMLS:C1968706	hp.json	Rudimentary fallopian tubes|Underdeveloped fallopian tube	http://purl.obolibrary.org/obo/HP_0008697		
UBERON:0001894	biolink:AnatomicalEntity	diencephalon	The division of the forebrain that develops from the foremost primary cerebral vesicle.	PBA:128013010|GAID:618|MESH:D004027|MAT:0000420|EHDAA2:0000385|FMA:62001|MA:0000171|EHDAA:3472|BIRNLEX:1503|Wikipedia:Diencephalon|MBA:1129|BTO:0000342|EHDAA:1969|DMBA:16308|MIAA:0000420|UMLS:C0012144|AAO:0010481|UMLS:C0012144|EV:0100194|OpenCyc:Mx4rwC-V0JwpEbGdrcN5Y29ycA|SCTID:279328001|BM:Die|EMAPA:16896|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=288|CALOHA:TS-0199|BAMS:IB|EHDAA:2645|XAO:0000013|DHBA:10389|ZFA:0000101|EFO:0000911|NCIT:C12456|BAMS:Zh.|BAMS:DiE|VHOG:0000318|TAO:0000101|HBA:4391|BAMS:Di|BAMS:DI	hp.json	diencephalon|mature diencephalon|betweenbrain|DiE|interbrain|thalamencephalon|diencephalon|between brain	http://purl.obolibrary.org/obo/UBERON_0001894		pheno_slim|efo_slim|uberon_slim|vertebrate_core
HP:0006035	biolink:PhenotypicFeature	Cone-shaped epiphyses of phalanges 2 to 5		UMLS:C1857005	hp.json	Cone-shaped end part of digital bones 2 to 5	http://purl.obolibrary.org/obo/HP_0006035		
HP:0008696	biolink:PhenotypicFeature	Renal hamartoma	A disordered proliferation of mature tissues that are native to the kidneys.	UMLS:C1840396	hp.json		http://purl.obolibrary.org/obo/HP_0008696		
UBERON:0001897	biolink:AnatomicalEntity	dorsal plus ventral thalamus	Subcortical brain region consisting of paired gray matter bodies in the dorsal diencephalon and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.(MeSH). The dorsal topographic division of the interbrain. The macrodissected adult human thalamus was clearly illustrated by Vesalius in 1543 and the term as defined here was introduced by His in 1893. It includes the traditional epithalamus, dorsal thalamus, and ventral thalamus of Herrick (1910, pp. 494, 498). Also see Kuhlenbeck (1927, Ch. 9) and Jones (1985, p. 87).	BIRNLEX:954|BAMS:Th|BAMS:TH|galen:Thalamus|VHOG:0000657|OpenCyc:Mx4rwMPQ65wpEbGdrcN5Y29ycA|UMLS:C0039729|AAO:0010483|UMLS:C0039729|BTO:0001365|DHBA:10390|EV:0100195|GAID:656|ZFA:0001215|MAT:0000109|NCIT:C12459|MA:0000179|PBA:128013014|TAO:0001215|MBA:549|MIAA:0000109|EFO:0000910|CALOHA:TS-1031|EMAPA:17540|HBA:4392|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=300|DMBA:16376	hp.json	wider thalamus|thalamus|thalamencephalon|Th|thalamus opticus|thalami	http://purl.obolibrary.org/obo/UBERON_0001897		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0001896	biolink:AnatomicalEntity	medulla oblongata	Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO].	MAT:0000367|EMAPA:17550|VHOG:0000181|XAO:0003100|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=698|SCTID:279104005|NCIT:C12442|FMA:62004|MESH:D008526|AAO:0010486|DMBA:17352|GAID:590|EHDAA:7588|MAT:0000111|UMLS:C0025148|BM:Me|OpenCyc:Mx4rvVjxSJwpEbGdrcN5Y29ycA|EHDAA2:0001088|EV:0100275|MBA:354|Wikipedia:Bone_marrow_of_ovary_oblongata|MIAA:0000111|MA:0000206|BAMS:MY|ZFA:0000545|BTO:0000041|EFO:0000924|TAO:0000545|UMLS:C0025148|BIRNLEX:957|OpenCyc:Mx4rwCqnXJwpEbGdrcN5Y29ycA|BAMS:Md|CALOHA:TS-0607|UMLS:C1269575	hp.json	medulla|metepencephalon|bulbus|medulla oblonzata|bulb|medulla oblonzata	http://purl.obolibrary.org/obo/UBERON_0001896		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0001891	biolink:AnatomicalEntity	midbrain	The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO].	EHDAA:3694|MBA:313|EV:0100242|BAMS:MES|EFO:0000919|DMBA:16649|BM:MB|DHBA:10648|BIRNLEX:1667|MA:0000207|EHDAA2:0001162|VHOG:0000069|ZFA:0000128|SCTID:279099009|EMAPA:16974|Wikipedia:Midbrain|UMLS:C0025462|CALOHA:TS-0630|UMLS:C0025462|RETIRED_EHDAA2:0001104|OpenCyc:Mx4rvsBUqpwpEbGdrcN5Y29ycA|XAO:0000014|TAO:0000128|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=462|MAT:0000106|AAO:0010149|HBA:9001|NCIT:C12510|BTO:0000138|MIAA:0000106|MESH:D008636|FMA:61993	hp.json	mesencephalon|mesencephalon|MB	http://purl.obolibrary.org/obo/UBERON_0001891		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0001890	biolink:AnatomicalEntity	forebrain	The most anterior region of the brain including both the telencephalon and diencephalon.	FMA:61992|Wikipedia:Forebrain|EFO:0000909|BAMS:Forebrain|ZFA:0000109|MA:0000170|EHDAA:3470|TAO:0000109|BAMS:FB|UMLS:C0085140|DMBA:15566|EMAPA:16895|VHOG:0000383|UMLS:C0085140|EHDAA2:0000556|SCTID:362291003|MAT:0000105|DHBA:10156|XAO:0000011|MESH:D016548|BIRNLEX:1509|AAO:0010147|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=27|NCIT:C40185|CALOHA:TS-0380|MIAA:0000105|BTO:0000478	hp.json	prosencephalon|FB	http://purl.obolibrary.org/obo/UBERON_0001890		efo_slim|human_reference_atlas|uberon_slim|vertebrate_core|pheno_slim
UBERON:0001893	biolink:AnatomicalEntity	telencephalon	Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres.	SCTID:263353005|MBA:567|HBA:4007|EV:0100165|MA:0000183|BAMS:Tel|Wikipedia:Telencephalon|MIAA:0000421|BAMS:CB|FMA:62000|CALOHA:TS-1018|EMAPA:16910|BIRNLEX:1115|BAMS:IV|UMLS:C0039452|GAID:621|EFO:0000912|DHBA:10158|VHOG:0000283|XAO:0000012|ZFA:0000079|BM:Tel|AAO:0010479|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=31|BTO:0000239|PBA:128011350|BAMS:CH|MESH:D013687|TAO:0000079|MAT:0000421|EHDAA2:0001982	hp.json	supratentorial region|endbrain|endbrain|supratentorial region|cerebrum|cerebrum	http://purl.obolibrary.org/obo/UBERON_0001893		pheno_slim|efo_slim|uberon_slim|vertebrate_core
HP:0008695	biolink:PhenotypicFeature	Transient nephrotic syndrome		UMLS:C4024638	hp.json	Transient nephrosis	http://purl.obolibrary.org/obo/HP_0008695		
UBERON:0001892	biolink:AnatomicalEntity	rhombomere	A segment of the developing hindbrain[ZFA]. In the vertebrate embryo, a rhombomere is a transiently divided segment of the developing neural tube, within the hindbrain region (a neuromere) in the area that will eventually become the rhombencephalon. The rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure.[WP].	FMA:295666|ZFA:0001064|RETIRED_EHDAA2:0000669|TAO:0001064|MAT:0000272|VHOG:0000672|EMAPA:16148|MIAA:0000272|Wikipedia:Rhombomere|EFO:0003617|DHBA:12664|XAO:0004079	hp.json	hindbrain neuromere|rhombomeres|segment of hindbrain|hindbrain segment|hindbrain neuromeres|future rhombencephalon|rhombomere	http://purl.obolibrary.org/obo/UBERON_0001892		pheno_slim|efo_slim|uberon_slim|vertebrate_core
HP:0008694	biolink:PhenotypicFeature	obsolete Hypertrophic labia minora			hp.json		http://purl.obolibrary.org/obo/HP_0008694		
HP:0031050	biolink:PhenotypicFeature	Whole-immunoglobulin paraproteinemia	An abnormal immunoglobulin (heavy and light chain) in the circulation and typically produced by a clonal population of B-cell derived plasma cells.		hp.json		http://purl.obolibrary.org/obo/HP_0031050		
IAO:0100001	biolink:NamedThing	term replaced by			hp.json		http://purl.obolibrary.org/obo/IAO_0100001		
HP:0031051	biolink:PhenotypicFeature	Tarsal sclerosis	An elevation in bone density in one or more tarsal bones of the foot. Sclerosis is normally detected on a radiograph as an area of increased opacity.		hp.json		http://purl.obolibrary.org/obo/HP_0031051		
HP:0006051	biolink:PhenotypicFeature	Metacarpal periosteal thickening		UMLS:C1834347	hp.json		http://purl.obolibrary.org/obo/HP_0006051		
HP:0031056	biolink:PhenotypicFeature	Fusiform cerebral aneurysm	A localized circumferential (i.e., bulges on all sides) dilatation or ballooning of a cerebral artery.		hp.json	Intracranial fusiform aneurysm	http://purl.obolibrary.org/obo/HP_0031056		
HP:0031057	biolink:PhenotypicFeature	Skin fissure	A clearly-defined and roughly linear cleavage in the skin that usually extends to the dermis.		hp.json	Cracked skin	http://purl.obolibrary.org/obo/HP_0031057		
HP:0031058	biolink:PhenotypicFeature	Impairment of activities of daily living	Difficulty in performing one or more activities normally performed every day, such as eating, bathing, dressing, grooming, work, homemaking, and leisure.		hp.json		http://purl.obolibrary.org/obo/HP_0031058		
HP:0031059	biolink:PhenotypicFeature	Impaired ability to bathe oneself	This term applies to an individual who requires help to bathe more than one part of the body, get in or out of the tub or shower, or who requires total bathing.		hp.json		http://purl.obolibrary.org/obo/HP_0031059		
UBERON:0011203	biolink:AnatomicalEntity	urachus mesenchyme	Mesenchyme that is part of a developing urachus.	EHDAA2:0004726	hp.json		http://purl.obolibrary.org/obo/UBERON_0011203		
HP:0031052	biolink:PhenotypicFeature	Elevated vascular endothelial growth factor level	Increased blood concentration of vascular endothelial growth factor (VEGF).		hp.json	Elevated circulating VEGF concentration	http://purl.obolibrary.org/obo/HP_0031052		
UBERON:0011202	biolink:AnatomicalEntity	urachus epithelium	An epithelium that is part of a urachus.	EHDAA2:0004725|NCIT:C54210|UMLS:C1711256	hp.json		http://purl.obolibrary.org/obo/UBERON_0011202		
HP:0031053	biolink:PhenotypicFeature	Coarctation in the transverse aortic arch	Narrowing or constriction of the aorta localized to the region of the transverse aortic arch.		hp.json		http://purl.obolibrary.org/obo/HP_0031053		
UBERON:0011201	biolink:AnatomicalEntity	muscle layer of small intestine	A muscle layer that is part of a small intestine.	FMA:14932|UMLS:C0227269|NCIT:C33569	hp.json	small intestine muscularis propria|tunica muscularis (intestinum tenue)|muscularis externa of small intestine|muscular coat of small intestine|muscular layer of small intestine|tunica muscularis intestini tenuis	http://purl.obolibrary.org/obo/UBERON_0011201		
HP:0031054	biolink:PhenotypicFeature	Long segment coarctation of the aorta	Coarctation of the aorta is a narrowing or constriction of a long segment of the arch of the aorta.		hp.json		http://purl.obolibrary.org/obo/HP_0031054		
UBERON:0011200	biolink:AnatomicalEntity	sacrococcygeal symphysis	The sacrococcygeal symphysis (sacrococcygeal articulation, articulation of the sacrum and coccyx) is an amphiarthrodial joint, formed between the oval surface at the apex of the sacrum, and the base of the coccyx. It is a slightly moveable joint which is frequently, partially or completely, obliterated in old age, homologous with the joints between the bodies of the vertebrae.	FMA:16210|NCIT:C33506|UMLS:C0224593	hp.json	sacrococcygeal joint|sacrococcygeal joint	http://purl.obolibrary.org/obo/UBERON_0011200		
HP:0031055	biolink:PhenotypicFeature	Abnormal branching pattern of left aortic arch	A deviance from the norm of the origin or course of the right brachiocephalic artery, the left common carotid artery, the left subclavian artery or the proximal vertebral arteries, whereby the aortic arch descends on the left as normal (as opposed to right aortic arch).		hp.json		http://purl.obolibrary.org/obo/HP_0031055		
UBERON:0035237	biolink:AnatomicalEntity	branch of internal carotid artery		NCIT:C32837|FMA:70506|SCTID:360629008|UMLS:C1182571	hp.json	subdivision of internal carotid artery|internal carotid arterial subdivision	http://purl.obolibrary.org/obo/UBERON_0035237		
UBERON:0001884	biolink:AnatomicalEntity	phrenic nerve	A nerve that arises from the caudal cervical nerves and is primarily the motor nerve of the diaphragm but also sends sensory fibers to the pericardium.	UMLS:C0031774|EHDAA:4677|GAID:848|MESH:D010791|SCTID:280344009|Wikipedia:Phrenic_nerve|NCIT:C52813|EMAPA:17813|FMA:6191|MA:0001170|BAMS:phn|BTO:0001063|VHOG:0000728|OpenCyc:Mx4rvtmdUJwpEbGdrcN5Y29ycA	hp.json	phrenic|nervus phrenicus|nervus phrenicus|nervus phrenicus|diaphragmatic nerve	http://purl.obolibrary.org/obo/UBERON_0001884		pheno_slim|human_reference_atlas|uberon_slim
PR:000001810	biolink:Protein	CSF-1/PDGF receptor-type tyrosine-protein kinase	A protein with core architecture consisting of asignal sequence, 5 Ig-like domains, followed by a transmembrane sequence, followed by a Protein tyrosine kinase domain (Pfam:PF07714). However, only 1-3 of the Ig domains are detected by the Pfam HMMs in most of the sequences. Pfam:PF00047 is most common, but other members of the Ig domain clan, Pfam:PF07679 and Pfam:PF07686 can be identified instead. The fourth Ig domain lacks the disulfide-bonded cysteines.	PIRSF:PIRSF000615	hp.json		http://purl.obolibrary.org/obo/PR_000001810		
HP:0006045	biolink:PhenotypicFeature	Short pointed phalanges		UMLS:C1849740	hp.json	Short pointed digital bones	http://purl.obolibrary.org/obo/HP_0006045		
UBERON:0001886	biolink:AnatomicalEntity	choroid plexus	A network formed by blood vessels and the tela choroidea which secretes CSF into the ventricular spaces.	MBA:108|MESH:D002831|TAO:0001443|BAMS:GHP|UMLS:C0008524|BTO:0000258|GAID:607|NCIT:C12694|BAMS:chpl|BAMS:chp|BAMS:CHP|EMAPA:32741|MA:0000823|VHOG:0001377|EFO:0001915|CALOHA:TS-0145|FMA:61934|ZFA:0001443	hp.json	plexus choroideus|chorioid plexus|CP|ventricular choroid plexus|plexus choroideus|choroid plexus of cerebral hemisphere	http://purl.obolibrary.org/obo/UBERON_0001886		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0001885	biolink:AnatomicalEntity	dentate gyrus of hippocampal formation	Part of the hippocampal formation forming a 'V' or 'U' shaped structure with the opening bounded by hippocampal area CA3. It consists of 3 layers from superficial to deep: molecular, granule cell and polymorphic or hilar layer.	UMLS:C0152314|BTO:0002615|NCIT:C32452|DHBA:10295|BAMS:DG|EFO:0001366|BM:Tel-DG|GAID:624|MA:0000190|BTO:0002496|MESH:D018891|CALOHA:TS-2388|BIRNLEX:1178|FMA:61922|DMBA:16115|MBA:726|EMAPA:19037|HBA:12891	hp.json	gyrus dentatus|dentate gyrus|dentate area|gyrus dentatus|area dentata|dentate area (dentate gyrus)|fascia dentata|hippocampal dentate gyrus	http://purl.obolibrary.org/obo/UBERON_0001885		pheno_slim|efo_slim|uberon_slim
HP:0006048	biolink:PhenotypicFeature	Distal widening of metacarpals	Abnormal increase in width of the distal region of the metacarpal bones.	UMLS:C1865254	hp.json	Wide outermost end of long bone	http://purl.obolibrary.org/obo/HP_0006048		
HP:0006042	biolink:PhenotypicFeature	Y-shaped metacarpals	Y-shaped metacarpals are the result of a partial fusion of two metacarpal bones, with the two arms of the Y pointing in the distal direction. Y-shaped metacarpals may be seen in combination with polydactyly.	UMLS:C1861373	hp.json	Y-shaped long bone of hand	http://purl.obolibrary.org/obo/HP_0006042		
UBERON:0011272	biolink:AnatomicalEntity	embryonic skin basal layer		EHDAA2:0001845	hp.json	outer epithelium of body|basal cell layer of skin	http://purl.obolibrary.org/obo/UBERON_0011272		
UBERON:0011270	biolink:AnatomicalEntity	dorsal trunk	The part of the trunk that is in the dorsum[cjm].	FMA:25056|Wikipedia:Human_back|EMAPA:35162|MA:0000020	hp.json	dorsal part of trunk|dorsum of trunk|back of trunk|trunk back	http://purl.obolibrary.org/obo/UBERON_0011270		
HP:0033642	biolink:PhenotypicFeature	Mitral valve leaflet calcification	Deposition of calcium salts in the leaflets (cusps) of the mitral valve.		hp.json		http://purl.obolibrary.org/obo/HP_0033642		
UBERON:0011276	biolink:AnatomicalEntity	nail of manual digit 4	A nail that is part of a manual digit 4.	FMA:54338|EMAPA:18737	hp.json	nail of ring finger|nail plate of ring finger|nail of fourth finger|nail of manual digit IV|ring finger nail|claw of digit 4 of fore-paw	http://purl.obolibrary.org/obo/UBERON_0011276		
UBERON:0011275	biolink:AnatomicalEntity	nail of manual digit 3	A nail that is part of a manual digit 3.	FMA:54335|EMAPA:18736	hp.json	nail of middle finger|middle finger nail|nail of third finger|nail plate of middle finger|nail of manual digit III|claw of digit 3 of fore-paw	http://purl.obolibrary.org/obo/UBERON_0011275		
HP:0033641	biolink:PhenotypicFeature	Aortic valve leaflet calcification	Deposition of calcium salts in the leaflets (cusps) of the aortic valve.		hp.json	Aortic cusp calcification|Aortic valve cusp calcification	http://purl.obolibrary.org/obo/HP_0033641		
UBERON:0011274	biolink:AnatomicalEntity	nail of manual digit 2	A nail that is part of a manual digit 2.	FMA:54332|EMAPA:18735	hp.json	index finger nail|nail plate of index finger|nail of manual digit II|claw of digit 2 of fore-paw|nail of second finger|nail of index finger	http://purl.obolibrary.org/obo/UBERON_0011274		
HP:0033644	biolink:PhenotypicFeature	Elevated circulating erythropoietin concentration	Increased amount of erythropoietin in the blood circulation. Erythropoietin is a glycoprotein hormone produced by the peritubular cells of the kidney that stimulates red blood cell production.		hp.json	Elevated circulating erythropoietin	http://purl.obolibrary.org/obo/HP_0033644		
UBERON:0011273	biolink:AnatomicalEntity	nail of manual digit 1	A nail that is part of a manual digit 1.	FMA:54329|EMAPA:18734	hp.json	nail of thumb|nail of manual digit I|nail plate of thumb|thumb nail|claw of digit 1 of fore-paw	http://purl.obolibrary.org/obo/UBERON_0011273		pheno_slim
HP:0033643	biolink:PhenotypicFeature	Increased circulating very long-chain fatty acid concentration	Increased concentation of very long-chain fatty acids in the blood circulation. Very long-chain fatty acids are fatty acids (FAs) with a chain-length of 22 or more carbons.		hp.json	Increased plasma levels of very long-chain fatty acid	http://purl.obolibrary.org/obo/HP_0033643		
UBERON:0011279	biolink:AnatomicalEntity	nail of pedal digit 2	A nail that is part of a pedal digit 2.	EMAPA:18740|FMA:54347	hp.json	second toe nail|nail plate of second toe|nail of second toe|claw of digit 2 of hind-paw|nail of pedal digit II	http://purl.obolibrary.org/obo/UBERON_0011279		
UBERON:0011278	biolink:AnatomicalEntity	nail of pedal digit 1	A nail that is part of a pedal digit 1.	EMAPA:18739|FMA:54344	hp.json	nail of first toe|nail plate of big toe|nail of pedal digit I|claw of digit 1 of hind-paw|big toe nail|nail of big toe|nail of great toe	http://purl.obolibrary.org/obo/UBERON_0011278		pheno_slim
HP:0033640	biolink:PhenotypicFeature	Acetabular erosions	Erosion (loss of substance) of the acetabular subchondral cortical bone. The acetabulum is the concave surface that meets with the head of the femur, forming the hip joint.		hp.json		http://purl.obolibrary.org/obo/HP_0033640		
UBERON:0011277	biolink:AnatomicalEntity	nail of manual digit 5	A nail that is part of a manual digit 5.	FMA:54341|EMAPA:18738	hp.json	nail of fifth finger|nail of little finger|nail plate of little finger|claw of digit 5 of fore-paw|nail of manual digit V|little finger nail	http://purl.obolibrary.org/obo/UBERON_0011277		pheno_slim
HP:0033649	biolink:PhenotypicFeature	Paraseptal emphysema	Paraseptal emphysema is characterized by predominant involvement of the distal alveoli and their ducts and sacs. It is characteristically bounded by any pleural surface and the interlobular septa. This emphysema is characterized by subpleural and peribronchovascular regions of low attenuation separated by intact interlobular septa, sometimes associated with bullae.		hp.json	Distal acinar emphysema	http://purl.obolibrary.org/obo/HP_0033649		
HP:0033646	biolink:PhenotypicFeature	Absent hippocampal commissure	Absence of the fibers that connect the contralateral hippocampi via the crura of the fornix and run beneath the posterior portion of the corpus callosum.		hp.json	Agenesis of the hippocampal commissure	http://purl.obolibrary.org/obo/HP_0033646		
HP:0033645	biolink:PhenotypicFeature	Midline brainstem cleft	A developmental defect characterized by an abnormal cleft (V-shaped indentation of the stalklike part of the brain consisting of the medulla oblongata, the midbrain, and the pons.		hp.json		http://purl.obolibrary.org/obo/HP_0033645		
HP:0033648	biolink:PhenotypicFeature	Pulmonary pseudocavity	A pseudocavity appears as an oval or round area of low attenuation in lung nodules, masses, or areas of consolidation that represent spared parenchyma, normal or ectatic bronchi, or focal emphysema rather than cavitation. These pseudocavities usually measure less than 1 cm in diameter. They have been described in patients with adenocarcinoma, bronchioloalveolar carcinoma, and benign conditions such as infectious pneumonia.		hp.json		http://purl.obolibrary.org/obo/HP_0033648		
HP:0033647	biolink:PhenotypicFeature	Silhouette sign	The silhouette sign is the absence of depiction of an anatomic soft-tissue border. It is caused by consolidation and/or atelectasis of the adjacent lung, by a large mass, or by contiguous pleural fluid. The silhouette sign results from the juxtaposition of structures of similar radiographic attenuation. The sign actually refers to the absence of a silhouette.		hp.json		http://purl.obolibrary.org/obo/HP_0033647		
PR:000001865	biolink:Protein	interleukin-3 receptor class 2 alpha chain	A protein that is a translation product of the human IL3RA gene or a 1:1 ortholog thereof.	IUPHARobj:1705	hp.json	Sut-1|IL-3R subunit alpha|IL-3R-alpha|IL-3RA|IL3R|IL-3 receptor subunit alpha|CD123|interleukin-3 receptor class II alpha chain|IL3RA	http://purl.obolibrary.org/obo/PR_000001865		
PR:000001867	biolink:Protein	interleukin-5 receptor subunit alpha	A protein that is a translation product of the human IL5RA gene or a 1:1 ortholog thereof.	IUPHARobj:1706|PIRSF:PIRSF018419	hp.json	CDw125|IL-5RA|IL-5R subunit alpha|IL-5R-alpha|IL5R|CD125|IL-5 receptor subunit alpha|IL5RA	http://purl.obolibrary.org/obo/PR_000001867		
PR:000001869	biolink:Protein	interleukin-7 receptor subunit alpha	A protein that is a translation product of the human IL7R gene or a 1:1 ortholog thereof.	IUPHARobj:1698|PIRSF:PIRSF001960	hp.json	CDw127|IL7R|IL-7RA|IL-7R subunit alpha|IL-7R-alpha|CD127|IL-7 receptor subunit alpha	http://purl.obolibrary.org/obo/PR_000001869		
HP:0006097	biolink:PhenotypicFeature	3-4 finger syndactyly	Syndactyly with fusion of fingers three and four.	UMLS:C1856889	hp.json	Webbed 3rd-4th fingers|Webbed 3rd-4th finger|Partial or complete syndactyly 3rd-4th fingers	http://purl.obolibrary.org/obo/HP_0006097		
HP:0006099	biolink:PhenotypicFeature	Metacarpophalangeal joint hyperextensibility	Increased mobility of one ore more metacarpophalangeal joint.	UMLS:C4025092	hp.json		http://purl.obolibrary.org/obo/HP_0006099		
CHEBI:26878	biolink:ChemicalSubstance	tertiary alcohol	A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.		hp.json	tertiary alcohol|tertiary alcohols	http://purl.obolibrary.org/obo/CHEBI_26878		3_STAR
CHEBI:26873	biolink:ChemicalSubstance	terpenoid	Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group.	Wikipedia:Terpenoid	hp.json	terpenoide|terpenoids|terpenoides|Terpenoid	http://purl.obolibrary.org/obo/CHEBI_26873		3_STAR
HP:0033653	biolink:PhenotypicFeature	Bronchocele	A bronchocele is bronchial dilatation due to retained secretions (mucoid impaction) usually caused by proximal obstruction, either congenital (eg, bronchial atresia) or acquired (eg, obstructing cancer). A bronchocele is a tubular or branching Y-or V-shaped structure that may resemble a gloved finger. The CT attenuation of the mucus is generally that of soft tissue but may be modified by its composition (eg, high-attenuation material in allergic bronchopulmonary aspergillosis). In the case of bronchial atresia, the surrounding lung may be of decreased attenuation because of reduced ventilation and, thus, perfusion.		hp.json		http://purl.obolibrary.org/obo/HP_0033653		
UBERON:0011265	biolink:AnatomicalEntity	carpometacarpal joint of digit 1	A carpometacarpal joint that connects to metacarpal 1.	FMA:35421	hp.json	carpometacarpal joint of digit I|trapeziometacarpal joint|TMJ|carpometacarpal joint of the thumb|carpometacarpal joint of pollex|carpometacarpal joint of thumb	http://purl.obolibrary.org/obo/UBERON_0011265		pheno_slim
HP:0033652	biolink:PhenotypicFeature	Broncholith	A broncholith, a calcified peribronchial lymph node that erodes into an adjacent bronchus, is most often the consequence of Histoplasma or tuberculous infection. The imaging appearance is of a small calcific focus in or immediately adjacent to an airway, most frequently the right middle lobe bronchus. Broncholiths are readily identified on CT scans. Distal obstructive changes may include atelectasis, mucoid impaction, and bronchiectasis		hp.json		http://purl.obolibrary.org/obo/HP_0033652		
HP:0033655	biolink:PhenotypicFeature	Pulmonary cavity	A gas-filled space, seen as lucency or low-attenuation area, within a nodule, mass or area of parenchymal consolidations. It has a clearly defined wall over 4 mm thick.		hp.json	Pulmonary cavern	http://purl.obolibrary.org/obo/HP_0033655		
HP:0033654	biolink:PhenotypicFeature	Beaded septum sign	Irregular and nodular thickening of interlobular septa reminiscent of a row of beads.		hp.json		http://purl.obolibrary.org/obo/HP_0033654		
HP:0033651	biolink:PhenotypicFeature	Pulmonary mycetoma	A mycetoma is a discrete mass of intertwined hyphae, usually of an Aspergillus species, matted together by mucus, fibrin, and cellular debris colonizing a cavity, usually from prior fibrocavitary disease (eg, tuberculosis or sarcoidosis). A mycetoma may move to a dependent location when the patient changes position and may show an air crescent sign. CT scans may show a spongelike pattern and foci of calcification in the mycetoma.		hp.json	Lung fungus ball	http://purl.obolibrary.org/obo/HP_0033651		
HP:0033650	biolink:PhenotypicFeature	Pulmonary parenchymal band	A parenchymal band is a linear opacity, usually 1-3 mm thick and up to 5 cm long that usually extends to the visceral pleura (which is often thickened and may be retracted at the site of contact). It reflects pleuroparenchymal fibrosis and is usually associated with distortion of the lung architecture. Parenchymal bands are most frequently encountered in individuals who have been exposed to asbestos.		hp.json		http://purl.obolibrary.org/obo/HP_0033650		
HP:0033657	biolink:PhenotypicFeature	Linear atelectasis	Linear atelectasis is a focal area of subsegmental atelectasis with a linear configuration, almost always extending to the pleura. It is commonly horizontal but sometimes oblique or vertical. The thickness of the atelectasis may range from a few millimeters to more than 1 cm.		hp.json	Platelike atelectasis|Discoid atelectasis	http://purl.obolibrary.org/obo/HP_0033657		
HP:0033656	biolink:PhenotypicFeature	Juxtaphrenic peak	A juxtaphrenic peak is a small triangular opacity based at the apex of the dome of a hemidiaphragm, associated with upper lobe volume loss of any cause (eg, postirradiation fibrosis or upper lobectomy). It is most readily appreciated on a frontal chest radiograph. The peak is caused by upward retraction of the inferior accessory fissure or an intrapulmonary septum associated with the pulmonary ligament.		hp.json		http://purl.obolibrary.org/obo/HP_0033656		
PR:000001874	biolink:Protein	KLRB1-like protein	A protein that is a translation product of the KLRB1 gene or its closely related paralogs (KLRB1A-F). There are lineage-specific expansions in mouse and rat.	PIRSF:PIRSF038804	hp.json		http://purl.obolibrary.org/obo/PR_000001874		
HP:0033659	biolink:PhenotypicFeature	obsolete Crazy-paving pattern			hp.json		http://purl.obolibrary.org/obo/HP_0033659		
HP:0033658	biolink:PhenotypicFeature	Rounded atelectasis	Rounded atelectasis is rounded collapsed lung associated with invaginated fibrotic pleura and thickened and fibrotic interlobular septa. Most frequently, it is the consequence of an asbestos-induced exudative pleural effusion with resultant pleural scarring, but it may occur with any cause of pleural fibrosis. On chest radiographs, rounded atelectasis appears as a mass abutting a pleural surface, usually in the posterior part of a lower lobe. Distorted vessels have a curvilinear disposition as they converge on the mass (the comet tail sign). The degree of lobar retraction depends on the volume of atelectatic lung. It is almost invariably associated with other signs of pleural fibrosis (eg, blunting of costophrenic angle). CT is more sensitive for the detection and display of the characteristic features of rounded atelectasis. An additional sign is homogeneous uptake of contrast medium in the atelectatic lung.		hp.json	Pleural pseudotumor|Blesovsky syndrome|Folded lung syndrome|Comet tail sign|Pleuroma|Helical atelectasis	http://purl.obolibrary.org/obo/HP_0033658		
CHEBI:38856	biolink:ChemicalSubstance	halophenol			hp.json	halophenol|halophenols	http://purl.obolibrary.org/obo/CHEBI_38856		3_STAR
PR:000001879	biolink:Protein	leukosialin	A protein that is a translation product of the human SPN gene or a 1:1 ortholog thereof.	PIRSF:PIRSF001994	hp.json	sialophorin|GALGP|B-cell differentiation antigen LP-3|leukocyte sialoglycoprotein|lymphocyte antigen 48|CD43|ly-48|galactoglycoprotein|SPN	http://purl.obolibrary.org/obo/PR_000001879		
HP:0200150	biolink:PhenotypicFeature	Increased serum bile acid concentration during pregnancy		UMLS:C4020695|UMLS:C4021882	hp.json	Increased serum bile acid concentration during pregnancy, resolves	http://purl.obolibrary.org/obo/HP_0200150		
HP:0200154	biolink:PhenotypicFeature	Agenesis of mandibular lateral incisor		UMLS:C4280283|UMLS:C4021880	hp.json	Absence of lower lateral incisor|Missing mandibular lateral incisor|Missing lower lateral incisor|Absence of mandibular lateral incisor|Failure of development of mandibular lateral incisor	http://purl.obolibrary.org/obo/HP_0200154		
UBERON:0011250	biolink:AnatomicalEntity	autopod bone	A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011250		
HP:0200153	biolink:PhenotypicFeature	Agenesis of lateral incisor		UMLS:C4021881|UMLS:C4227831	hp.json	Failure of development of lateral incisor|Missing lateral incisor|Absence of lateral incisor	http://purl.obolibrary.org/obo/HP_0200153		
HP:0200151	biolink:PhenotypicFeature	Cutaneous mastocytosis	Multifocal dense infiltrates of mast cells in cutaneous tissue.	SNOMEDCT_US:397012002|UMLS:C1136033|MSH:D034701|SNOMEDCT_US:703827008	hp.json		http://purl.obolibrary.org/obo/HP_0200151		
HP:0031001	biolink:PhenotypicFeature	Minifascicle formation	A nerve fascicle or fasciculus is a small bundle of axons, enclosed by the perineurium. A minifascule refers to a group of thinly myelinated and unmyelinated axons surrounded by a delicate perineurium, and with a smaller diameter than a normal nerve fascicle.		hp.json		http://purl.obolibrary.org/obo/HP_0031001		
HP:0200158	biolink:PhenotypicFeature	Agenesis of permanent mandibular lateral incisor		UMLS:C4280282|UMLS:C4021879	hp.json	Absence of adult mandibular lateral incisor|Missing permanent mandibular lateral incisor|Absence of permanent mandibular lateral incisor|Failure of development of permanent mandibular lateral incisor|Missing adult lower lateral incisor	http://purl.obolibrary.org/obo/HP_0200158		
HP:0033664	biolink:PhenotypicFeature	Ganglioglioma	Gangliogliomas are rare tumours of the central nervous system. The are WHO grade I and considered low grade. They are well differentiated neuroepithelial tumours consisting of both dysplastic neuronal and neoplastic glial cells.	NCIT:C3788	hp.json		http://purl.obolibrary.org/obo/HP_0033664		
HP:0031002	biolink:PhenotypicFeature	Neuritis	Inflammation of a nerve.		hp.json		http://purl.obolibrary.org/obo/HP_0031002		
HP:0033663	biolink:PhenotypicFeature	Air trapping	Air trapping is retention of air in the lung distal to an obstruction (usually partial). Air trapping is seen on end-expiration CT scans as parenchymal areas with less than normal increase in attenuation and lack of volume reduction. Comparison between inspiratory and expiratory CT scans can be helpful when air trapping is subtle or diffuse.		hp.json		http://purl.obolibrary.org/obo/HP_0033663		
HP:0033666	biolink:PhenotypicFeature	Diminished physical functioning	A reduction in the ability to perform activities of daily living as compared to previous abilities because of functional deficits due to illness. The 36-item Short Form (SF-36) health survey questionnaire is one of many methods used to measure patients' perceptions of diminished physical functioning.		hp.json	Diminished physical health|Decline in physical functional health	http://purl.obolibrary.org/obo/HP_0033666		
HP:0031003	biolink:PhenotypicFeature	Polyneuritis	Simulataneous inflammation of multiple nerves.		hp.json	Multiple neuritis	http://purl.obolibrary.org/obo/HP_0031003		
HP:0033665	biolink:PhenotypicFeature	Diminished health-related quality of life	A reduction in an individual's subjective assessment of his or her sense of well-being and ability to perform social roles.		hp.json		http://purl.obolibrary.org/obo/HP_0033665		
HP:0031004	biolink:PhenotypicFeature	Hemiareflexia	Areflexia that is limited to one side of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0031004		
HP:0033660	biolink:PhenotypicFeature	Hand paresthesia	Tingling (often refered to as a pins and needles feeling) and numbness in the hand.		hp.json	Hand tingling	http://purl.obolibrary.org/obo/HP_0033660		
HP:0033662	biolink:PhenotypicFeature	Air bronchogram	An air bronchogram is a pattern of air-filled (low-attenuation) bronchi on a background of opaque (high-attenuation) airless lung. The sign implies (a) patency of proximal airways and (b) evacuation of alveolar air by means of absorption (atelectasis) or replacement (eg, pneumonia) or a combination of these processes. In rare cases, the displacement of air is the result of marked interstitial expansion (eg, lymphoma).		hp.json		http://purl.obolibrary.org/obo/HP_0033662		
HP:0031000	biolink:PhenotypicFeature	Vestibular saccular degeneration	Deterioration or loss of the tissues of the saccule of the vestibule.		hp.json		http://purl.obolibrary.org/obo/HP_0031000		
HP:0200159	biolink:PhenotypicFeature	Agenesis of primary mandibular lateral incisor		UMLS:C4280281|UMLS:C4280280|UMLS:C4021878	hp.json	Absence of deciduous mandibular lateral incisor|Failure of development of deciduous mandibular lateral incisor|Agenesis of deciduous mandibular lateral incisor|Absence of lower front baby tooth|Missing primary mandibular lateral incisor|Missing deciduous mandibular lateral incisor|Absence of primary mandibular lateral incisor|Failure of development of primary mandibular lateral incisor	http://purl.obolibrary.org/obo/HP_0200159		
HP:0033661	biolink:PhenotypicFeature	Air crescent	An air crescent is a collection of air in a crescentic shape that separates the wall of a cavity from an inner mass. The air crescent sign is often considered characteristic of either Aspergillus colonization of preexisting cavities or retraction of infarcted lung in angioinvasive aspergillosis. However, the air crescent sign has also been reported in other conditions, including tuberculosis, Wegener granulomatosis, intracavitary hemorrhage, and lung cancer.		hp.json		http://purl.obolibrary.org/obo/HP_0033661		
HP:0031009	biolink:PhenotypicFeature	Ainhum	Development of a fibrotic constriction ring involving the base of one or more toes, conditioning eversion and absorption of distal structures, possibly progressing to spontaneous amputation.		hp.json	Dactylolysis spontanea	http://purl.obolibrary.org/obo/HP_0031009		
UBERON:0011249	biolink:AnatomicalEntity	appendicular skeletal system	Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints.	FMA:7484|VHOG:0001666|VSAO:0000306	hp.json		http://purl.obolibrary.org/obo/UBERON_0011249		
HP:0033668	biolink:PhenotypicFeature	Abnormal amygdala morphology	A structural anomaly of the amygdala.		hp.json	Abnormal morphology of the amygdala	http://purl.obolibrary.org/obo/HP_0033668		
HP:0031005	biolink:PhenotypicFeature	obsolete Hyperalgesia			hp.json		http://purl.obolibrary.org/obo/HP_0031005		
HP:0031006	biolink:PhenotypicFeature	Acroparesthesia	A type of paresthesia (tingling, pins-and-needles, burning or numbness or stiffness) that occurs in the hands and feet and particularly in the fingers and toes.		hp.json		http://purl.obolibrary.org/obo/HP_0031006		
HP:0033667	biolink:PhenotypicFeature	Diminished mental health	A reduction in the subjective feeling of mental well being.		hp.json	Mental impairment|Reduced mental health	http://purl.obolibrary.org/obo/HP_0033667		
HP:0031007	biolink:PhenotypicFeature	Orofacial action-specific dystonia induced by speech			hp.json	Jaw dystonia induced by speaking	http://purl.obolibrary.org/obo/HP_0031007		
HP:0033669	biolink:PhenotypicFeature	Enlarged amygdala	A increase in the volume (size) of the amygdyla.		hp.json	Amygdalar enlargement	http://purl.obolibrary.org/obo/HP_0033669		
HP:0031008	biolink:PhenotypicFeature	Lingual dystonia	Involuntary protrusions, movements, spams and contortions of the tongue.		hp.json	Tongue dystonia	http://purl.obolibrary.org/obo/HP_0031008		
PR:000001843	biolink:Protein	Thy-1 membrane glycoprotein	A protein that is a translation product of the human THY1 gene or a 1:1 ortholog thereof.	PIRSF:PIRSF038777	hp.json	Thy-1|CDw90|THY1|CD90|Thy-1 antigen	http://purl.obolibrary.org/obo/PR_000001843		
HP:0006077	biolink:PhenotypicFeature	Absent proximal finger flexion creases	Absence of the proximal interphalangeal flexion creases of the fingers.	UMLS:C1850048	hp.json		http://purl.obolibrary.org/obo/HP_0006077		
HP:0006092	biolink:PhenotypicFeature	Malaligned carpal bone	Malalignement of carpal bone angles either with respect to each other, to the corresponding metacarpals or with respect to the wrist (radius and ulna).	UMLS:C1856742	hp.json	Incorrect alignment of wrist bone	http://purl.obolibrary.org/obo/HP_0006092		
HP:0200161	biolink:PhenotypicFeature	Agenesis of mandibular incisor		UMLS:C4021876|UMLS:C4280277|UMLS:C3150012	hp.json	Missing lower front tooth|Absence of lower incisor|Absence of lower front tooth|Agenesis of lower incisor|Missing lower incisor|Failure of development of mandibular incisor|Absence of mandibular incisor	http://purl.obolibrary.org/obo/HP_0200161		
HP:0200160	biolink:PhenotypicFeature	Agenesis of maxillary incisor		UMLS:C4280279|UMLS:C4280278|UMLS:C4021877	hp.json	Absence of maxillary incisor|Missing upper front tooth|Absence of upper front tooth|Failure of development of maxillary incisor|Missing upper incisor|Failure of development of upper incisor	http://purl.obolibrary.org/obo/HP_0200160		
HP:0006094	biolink:PhenotypicFeature	Finger joint hypermobility		UMLS:C0574974|SNOMEDCT_US:298193009	hp.json	Increased mobility in finger joint	http://purl.obolibrary.org/obo/HP_0006094		
HP:0006095	biolink:PhenotypicFeature	Wide tufts of distal phalanges		UMLS:C1835101	hp.json	Wide tips of outermost digital bone	http://purl.obolibrary.org/obo/HP_0006095		
HP:0033675	biolink:PhenotypicFeature	Frailty	A clinically recognizable state of increased vulnerability resulting from a decline in reserve and function across multiple physiologic systems such that the ability to cope with everyday or acute stressors is compromised.		hp.json		http://purl.obolibrary.org/obo/HP_0033675		
HP:0031012	biolink:PhenotypicFeature	Thin-cap fibroatheroma	Thin-cap fibroatheroma is characterized by a relatively large necrotic core with an overlying thin fibrous cap measuring less than 65 micrometers and typically containing numerous macrophages, and is considered to be the precursor lesion of plaque rupture which is the most common cause of coronary thrombosis.		hp.json	TCFA	http://purl.obolibrary.org/obo/HP_0031012		
HP:0033674	biolink:PhenotypicFeature	Pulmonary blood flow redistribution	Pulmonary blood flow redistribution refers to any departure from the normal distribution of blood flow in the lungs that is caused by an increase in pulmonary vascular resistance elsewhere in the pulmonary vascular bed. Pulmonary blood flow redistribution is indicated by a decrease in the size and/or number of visible pulmonary vessels in one or more lung regions, with a corresponding increase in number and/or size of pulmonary vessels in other parts of the lung.		hp.json		http://purl.obolibrary.org/obo/HP_0033674		
HP:0031013	biolink:PhenotypicFeature	Ankylosis	A reduction of joint mobility resulting from changes involving the articular surfaces.		hp.json		http://purl.obolibrary.org/obo/HP_0031013		
HP:0033677	biolink:PhenotypicFeature	Acute respiratory distress syndrome	Acute respiratory distress syndrome (ARDS) is defined as an acute disorder that starts within seven days of the inciting event and is characterized by bilateral lung infiltrates and severe progressive hypoxemia in the absence of any evidence of cardiogenic pulmonary edema. ARDS is defined by the patient's oxygen in arterial blood (PaO2) to the fraction of the oxygen in the inspired air (FiO2). These patients have a PaO2/FiO2 ratio of less than 300.		hp.json	ARDS	http://purl.obolibrary.org/obo/HP_0033677		
HP:0031014	biolink:PhenotypicFeature	Arteria lusoria	Usually, three large arteries arise from the arch of the aorta: the brachiocephalic trunk (divided into the right common carotid artery and the right subclavian artery), the left common carotid artery, and the left subclavian artery. However, when aberrant right subclavian artery variant is present, the brachiocephalic trunk is absent and four large arteries arise from the arch of the aorta: the right common carotid artery, the left common carotid artery, the left subclavian artery, and the final one with the most distal left sided origin, the right subclavian artery, also called the arteria lusoria.		hp.json	Lusorian artery|Aberrant right subclavian artery	http://purl.obolibrary.org/obo/HP_0031014		
UBERON:0011241	biolink:AnatomicalEntity	ethmoid region	The most anterior region of the braincase. Provides structural support for peripheral olfactory organ.	AAO:0000986	hp.json		http://purl.obolibrary.org/obo/UBERON_0011241		
HP:0033676	biolink:PhenotypicFeature	Posttraumatic stress symptom	A behavioral or psychological symptom that typically occurs following exposure to one or more traumatic events. Posttraumatic stress disorder (PTSD) symptoms include intrusive recollections (re-experiencing the trauma in flashbacks, memories or nightmares); avoidant and numbing symptoms (including diminished emotions and avoidance of situations that are reminders of the traumatic event); and hyperarousal (including increased irritability, exaggerated startle reactions or difficulty sleeping or concentrating).		hp.json	PTSD	http://purl.obolibrary.org/obo/HP_0033676		
HP:0031015	biolink:PhenotypicFeature	Intrahepatic portal vein sclerosis	Sclerosis of the intrahepatic portal veins of the liver and generally accompanied by non-cirrhotic portal hypertension, features of which may include splenomegaly and varices.		hp.json	Incomplete septal cirrhosis|Non cirrhotic portal fibrosis|Obliterative portal venopathy|Idiopathic non-cirrhotic portal hypertension	http://purl.obolibrary.org/obo/HP_0031015		
HP:0033671	biolink:PhenotypicFeature	Pulmonary oligemia	Oligemia is a reduction in pulmonary blood volume. Most frequently, this reduction is regional, but occasionally it is generalized. Regional oligemia is usually associated with reduced blood flow in the oligemic area. Oligemia appears as a regional or widespread decrease in the size and number of identifiable pulmonary vessels, which is indicative of less than normal blood flow.		hp.json		http://purl.obolibrary.org/obo/HP_0033671		
HP:0033670	biolink:PhenotypicFeature	Organizing pneumonia	Organizing pneumonia manifests as a histologic pattern characterized by loose plugs of connective tissue in the airspaces and distal airways. Interstitial inflammation and fibrosis are minimal or absent. Cryptogenic organizing pneumonia, or COP, is a distinctive clinical disorder among the idiopathic interstitial pneumonias, but the histologic pattern of organizing pneumonia is encountered in many different situations, including pulmonary infection, hypersensitivity pneumonitis, and collagen vascular diseases. Airspace consolidation is the cardinal feature of organizing pneumonia on chest radiographs and CT scans. In COP, the distribution is typically subpleural and basal and sometimes bronchocentric. Other manifestations of organizing pneumonia include groundglass opacity, tree-in-bud pattern, and nodular opacities.		hp.json		http://purl.obolibrary.org/obo/HP_0033670		
HP:0033673	biolink:PhenotypicFeature	Positive Phalen test	The Phalen maneuver is performed by having the patient hold both wrists in complete and forced flexion (pushing the dorsal surfaces of both hands together) for 30-60 seconds. This can increase the pressure in the carpal tunnel. The test is positive (abnormal) if the patient experiences characteristic symptoms of carpal tunnel syndrome (pain and paresthesias along the distribution of the median nerve, i.e., thumb, index finger, and middle finger).		hp.json	Phalen manoeuvre|Phalen maneuver	http://purl.obolibrary.org/obo/HP_0033673		
HP:0031010	biolink:PhenotypicFeature	Hyperphalangy of the 3rd finger	An accessory phalanx of the third (middle) finger that is arranged linearly with the other phalanges. Hyperphalangy results from an accessory ossification center at the metacarpophalangeal joint.		hp.json	Hyperphalangy of third finger	http://purl.obolibrary.org/obo/HP_0031010		
HP:0033672	biolink:PhenotypicFeature	Positive carpal Tinel sign	The Tinel test is performed by lightly tapping (percussing) over the median nerve. It is positive (abnormal) if the patient experiences pain and paresthesias (tingling, numbness) along the distribution of the median nerve.		hp.json	Positive carpal Hoffmann Tinel sign	http://purl.obolibrary.org/obo/HP_0033672		
HP:0031011	biolink:PhenotypicFeature	Fatty streak	Yellow-colored streaks, patches, or spots on the intimal surface of arteries. Fatty streaks stain red with Sudan III or Sudan IV.		hp.json	Sudanophilic lesion	http://purl.obolibrary.org/obo/HP_0031011		
PR:000001850	biolink:Protein	cathepsin K	A cathepsin-like protease that is a translation product of the human CTSK gene or a 1:1 ortholog thereof.	IUPHARobj:2350	hp.json	cathepsin X|CTSO2|CTSK|cathepsin O2|cathepsin O|CTSO	http://purl.obolibrary.org/obo/PR_000001850		
HP:0031016	biolink:PhenotypicFeature	Alternating radiolucent and radiodense metaphyseal lines	Areas of radio-opaque sclerotic bands alternating with those of normal lucency give rise to stripes akin to a zebra.		hp.json	Zebra stripe sign	http://purl.obolibrary.org/obo/HP_0031016		
HP:0033679	biolink:PhenotypicFeature	Abnormal red nucleus morphology	Any structural anomaly of the red nucleus, a part of the midbrain involved in control of movement.		hp.json		http://purl.obolibrary.org/obo/HP_0033679		
HP:0033678	biolink:PhenotypicFeature	Acute coronary syndrome	The term acute coronary syndrome (ACS) refers to any group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI).		hp.json		http://purl.obolibrary.org/obo/HP_0033678		
HP:0031017	biolink:PhenotypicFeature	Swiss cheese atrial septal defect	Multiple defects in the atrial septum.		hp.json		http://purl.obolibrary.org/obo/HP_0031017		
HP:0031018	biolink:PhenotypicFeature	Eccrine syringofibroadenoma	Eccrine syringofibroadenoma (ESFA) is a benign adnexal tumor arising most often on the extremities of elderly individuals characterized by anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells and ductal structures. ESFA stains positively with epithelial membrane antigen (EMA) and carcinoembryonic antigen (CEA).		hp.json	Syringofibroadenoma|Eccrine syringofibroadenomatous hyperplasia|Acrosyringeal adenomatosis	http://purl.obolibrary.org/obo/HP_0031018		
HP:0031019	biolink:PhenotypicFeature	Pyknotic bone marrow neutrophils	Nuclear lobes of neutrophils in the bone marrow are thickened and condensed, and individual lobes are connected by unusually long chromatin filaments.		hp.json		http://purl.obolibrary.org/obo/HP_0031019		
HP:0006089	biolink:PhenotypicFeature	Palmar hyperhidrosis		UMLS:C1856953	hp.json	Excessive sweating of hands	http://purl.obolibrary.org/obo/HP_0006089		
HP:0006086	biolink:PhenotypicFeature	Thin metacarpal cortices		UMLS:C1850160	hp.json		http://purl.obolibrary.org/obo/HP_0006086		
HP:0006088	biolink:PhenotypicFeature	1-5 finger complete cutaneous syndactyly		UMLS:C1861357	hp.json		http://purl.obolibrary.org/obo/HP_0006088		
UBERON:0001826	biolink:AnatomicalEntity	nasal cavity mucosa	The mucous membrane that lines the nasal cavity[MP].	CALOHA:TS-0657|EMAPA:36026|GAID:302|FMA:59684|BTO:0000912	hp.json	mucosa of nose|nasal mucosa|mucous membrane of nose|tunica mucosa nasalis|tunica mucosa nasi	http://purl.obolibrary.org/obo/UBERON_0001826		pheno_slim
GO:0097475	biolink:BiologicalProcess	motor neuron migration	The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.		hp.json		http://purl.obolibrary.org/obo/GO_0097475		
UBERON:0001825	biolink:AnatomicalEntity	paranasal sinus	The paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity.	CALOHA:TS-2082|FMA:59679|EMAPA:35662|GAID:355|MA:0000431|EV:0100038|UMLS:C0030471|MESH:D010256|NCIT:C12763|EHDAA:6489	hp.json	nasal sinus|sinus	http://purl.obolibrary.org/obo/UBERON_0001825		uberon_slim|pheno_slim
GO:0097474	biolink:BiologicalProcess	retinal cone cell apoptotic process	Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina.		hp.json	cone photoreceptor apoptotic process	http://purl.obolibrary.org/obo/GO_0097474		
UBERON:0001828	biolink:AnatomicalEntity	gingiva	The fibrous investing tissue, covered by keratinized epithelium, that immediately surrounds a tooth and is contiguous with its periodontal ligament and with the mucosal tissues of the mouth[Glossary of Periodontal Terms 2001].	GAID:1257|EMAPA:35945|EV:0100064|VHOG:0001269|MESH:D005881|BTO:0000519|UMLS:C0017562|FMA:59762|EFO:0001925|NCIT:C32677|OpenCyc:Mx4rvViWnZwpEbGdrcN5Y29ycA|MA:0000342|galen:Gingiva|CALOHA:TS-2074	hp.json	gums|gum|gum tissue|gingival mucosa	http://purl.obolibrary.org/obo/UBERON_0001828		pheno_slim|efo_slim|uberon_slim
UBERON:0001827	biolink:AnatomicalEntity	secretion of lacrimal gland	Aqueous substance secreted by the lacrimal gland.	EMAPA:36537|BTO:0001499|MA:0002508|NCIT:C33739|FMA:59756|galen:Tears|CALOHA:TS-1016|GAID:1173|galen:Tear|MESH:D013666|ENVO:02000034|UMLS:C0039409	hp.json	tears|tear fluid|tear|lacrimal fluid|lacrimal gland secretion|lacrimal secretion	http://purl.obolibrary.org/obo/UBERON_0001827		uberon_slim
GO:0097476	biolink:BiologicalProcess	spinal cord motor neuron migration	The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.		hp.json		http://purl.obolibrary.org/obo/GO_0097476		
UBERON:0001821	biolink:AnatomicalEntity	sebaceous gland	A holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.[MP].	VHOG:0001468|NCIT:C33519|EMAPA:35754|GAID:900|BTO:0001980|EV:0100161|MESH:D012627|MA:0002565|CALOHA:TS-2384|UMLS:C0036505|FMA:59160	hp.json	sebaceous follicle|glandula sebacea|glandula sebaceae	http://purl.obolibrary.org/obo/UBERON_0001821		human_reference_atlas|uberon_slim|organ_slim|pheno_slim
UBERON:0001824	biolink:AnatomicalEntity	mucosa of larynx	The mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx.	NCIT:C49246|MESH:D007820|SCTID:361940006|MA:0001766|GAID:301|FMA:59662|EMAPA:18334|UMLS:C0023053	hp.json	larynx mucous membrane|laryngeal mucosa|mucosa of organ of larynx|tunica mucosa laryngis|organ mucosa of larynx|mucous membrane of larynx|larynx mucosa|laryngeal mucous membrane|larynx mucosa of organ|larynx organ mucosa	http://purl.obolibrary.org/obo/UBERON_0001824		
GO:0097473	biolink:BiologicalProcess	retinal rod cell apoptotic process	Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.		hp.json	rod photoreceptor apoptotic process	http://purl.obolibrary.org/obo/GO_0097473		
UBERON:0001823	biolink:AnatomicalEntity	nasal cartilage	One of the cartilage structures in the nose that provide form and support[WP].	CALOHA:TS-0655|FMA:59502|EMAPA:37681|MESH:D055171|NCIT:C49593|MA:0001883|UMLS:C0225415	hp.json	cartilage of nose	http://purl.obolibrary.org/obo/UBERON_0001823		uberon_slim|pheno_slim
HP:0033600	biolink:PhenotypicFeature	Fibrillary glomerular subepithelial deposits	A type of fibrillar glomerular subepithelial deposit characterized by extracellular aggregates of randomly arranged, straight, non-branching fibrils that are thicker than amyloid fibrils (average diameter about 20 nm) and are often admixed with smudgy, electron-dense material. This feature is associated with a prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).		hp.json		http://purl.obolibrary.org/obo/HP_0033600		
UBERON:0001829	biolink:AnatomicalEntity	major salivary gland	One of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands.	FMA:59788|NCIT:C12999|MA:0002478|UMLS:C0930553|galen:MajorSalivaryGland	hp.json		http://purl.obolibrary.org/obo/UBERON_0001829		pheno_slim|organ_slim
CHEBI:48299	biolink:ChemicalSubstance	butane-1,2,3,4-tetrol	A tetritol that is butane substituted by hydroxy groups at positions 1, 2, 3 and 4.	Reaxys:1735878|Beilstein:1735878|CAS:7541-59-5|KEGG:C00503|CAS:149-32-6|KEGG:D08915|KNApSAcK:C00001161	hp.json	Phycitol|Phycite|Erythrite|1,2,3,4-tetrahydroxybutane|butane-1,2,3,4-tetrol|Erythrol	http://purl.obolibrary.org/obo/CHEBI_48299		3_STAR
HP:0008639	biolink:PhenotypicFeature	Gonadal hypoplasia		UMLS:C0239761	hp.json	Underdeveloped gonad	http://purl.obolibrary.org/obo/HP_0008639		
HP:0033606	biolink:PhenotypicFeature	Bone marrow maturation arrest	Interruption of the procecss of diffferentiation of hematopoietic cells in the bone marrow, manifested by an increased proportion of immature cells in the bone marrow.		hp.json	Haematopoietic maturation arrest|Hematopoietic maturation arrest	http://purl.obolibrary.org/obo/HP_0033606		
HP:0033605	biolink:PhenotypicFeature	Pustular rash	A rash composed of pustular lesions. A pustule is defined as a vesicle or bulla containing purulent material. It varies in size and may occur at different levels within the epidermis: subcorneal, intraepidermal, or basement membrane zones. The pustules may or may not be sterile and are normally filled with neutrophils.		hp.json	Pustulosis	http://purl.obolibrary.org/obo/HP_0033605		
HP:0033608	biolink:PhenotypicFeature	Pulmonary nodule	Focal rounded or ovoid opacity, not more than 3 cm in diameter. Pulmonary nodules are typically observed by chest radiography or computer tomography imaging.		hp.json	Spot on the lung	http://purl.obolibrary.org/obo/HP_0033608		
HP:0033607	biolink:PhenotypicFeature	Bone marrow arrest at the promyelocytic stage	A type of bone marrow maturation arrest characterized by accumulation of neutrophil precursor cells in the bone marrow.		hp.json		http://purl.obolibrary.org/obo/HP_0033607		
GO:1901052	biolink:BiologicalProcess	sarcosine metabolic process	The chemical reactions and pathways involving sarcosine.		hp.json	sarcosine metabolism	http://purl.obolibrary.org/obo/GO_1901052		
HP:0033602	biolink:PhenotypicFeature	Glomerular hyaline subepithelial deposits	A type of glomerular subepithelial deposit characterized by a moderately electron-dense, generally homogenous, amorphous-appearing extracellular material located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature is associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).		hp.json		http://purl.obolibrary.org/obo/HP_0033602		
HP:0008635	biolink:PhenotypicFeature	Hypertrophy of the urinary bladder	Abnormal enlargement of the urinary bladder.	UMLS:C4021531	hp.json	Hypertrophic urinary bladder	http://purl.obolibrary.org/obo/HP_0008635		
HP:0033601	biolink:PhenotypicFeature	Glomerular subepithelial immune-complex deposits	A type of glomerular subepithelial deposit characterized by finely granular material deposited between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM and corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry. This feature is associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).		hp.json		http://purl.obolibrary.org/obo/HP_0033601		
HP:0033604	biolink:PhenotypicFeature	Glomerular capillary wire loop deposits	Glomerulus showing markedly and irregularly thickened capillary walls with massive fuchsinophilic subendothelial deposits, resulting in narrowing of capillary lumina. This feature is said to resemble a wire loop.		hp.json		http://purl.obolibrary.org/obo/HP_0033604		
HP:0033603	biolink:PhenotypicFeature	Glomerular subepithelial deposits	Deposits located between the outer (epithelial) aspect of the glomerular basement membrane (GBM) and the visceral epithelial cell, with varying degrees of incorporation into the GBM. This feature may be associated with a prominent GBM reflecting an diffuse and relativly uniform increase in thickness (subjective estimate).		hp.json		http://purl.obolibrary.org/obo/HP_0033603		
HP:0008636	biolink:PhenotypicFeature	Lobular glomerulopathy		UMLS:C4024651	hp.json		http://purl.obolibrary.org/obo/HP_0008636		
HP:0008631	biolink:PhenotypicFeature	Ureteral dysgenesis	A developmental anomaly of the ureter.	UMLS:C4024653	hp.json		http://purl.obolibrary.org/obo/HP_0008631		
UBERON:0001831	biolink:AnatomicalEntity	parotid gland	The parotid gland is the largest of the salivary glands. It is found wrapped around the mandibular ramus, and it secretes saliva through Stensen's duct into the oral cavity, to facilitate mastication and swallowing. [WP,unvetted].	EMAPA:18537|AAO:0010095|MESH:D010306|galen:ParotidGland|EV:0100060|NCIT:C12427|OpenCyc:Mx4rvqwyg5wpEbGdrcN5Y29ycA|VHOG:0000308|MA:0001585|EFO:0002558|FMA:59790|UMLS:C0030580|CALOHA:TS-0748|GAID:938|BTO:0001004	hp.json	parotid|glandula parotidea	http://purl.obolibrary.org/obo/UBERON_0001831		uberon_slim|pheno_slim|efo_slim
HP:0008633	biolink:PhenotypicFeature	Agonadism	Absence of sex glands (gonads are the organs that produce gametes; testis in males and ovary in females).	UMLS:C4024652	hp.json	Gonadal agenesis|Absent gonadal tissue	http://purl.obolibrary.org/obo/HP_0008633		
HP:0033609	biolink:PhenotypicFeature	Solid pulmonary nodule	A type of pulmonary nodule whose density obscures the underlying parenchyma and thus has a "solid" appearance.		hp.json		http://purl.obolibrary.org/obo/HP_0033609		
UBERON:0001815	biolink:AnatomicalEntity	lumbosacral nerve plexus	An arrangement of nerve fibers, running from the spine that travels to the pelvic appendage where it innervates skin and muscle.	GAID:849|NCIT:C52805|EHDAA:4673|BAMS:lsp|MA:0001181|EHDAA2:0001040|EMAPA:17587|VHOG:0000926|FMA:5907|OpenCyc:Mx4rvzYo75wpEbGdrcN5Y29ycA|MESH:D008160|UMLS:C0024093	hp.json	lumbosacral plexus|plexus lumbosacralis|plexus lumbosacralis	http://purl.obolibrary.org/obo/UBERON_0001815		uberon_slim
UBERON:0001814	biolink:AnatomicalEntity	brachial nerve plexus	An arrangement of nerve fibers, running from the spine where it proceeds through the neck then the axilla and into the arm where it innervates skin and muscle. [WP,modified].	EHDAA:3782|NCIT:C12682|MESH:D001917|OpenCyc:Mx4rwNWmO5wpEbGdrcN5Y29ycA|EMAPA:16988|MA:0001180|GAID:842|UMLS:C0006090|EHDAA2:0000180|VHOG:0000372|FMA:5906	hp.json	plexus brachialis|brachial plexus|plexus brachialis	http://purl.obolibrary.org/obo/UBERON_0001814		human_reference_atlas|uberon_slim
UBERON:0001817	biolink:AnatomicalEntity	lacrimal gland	The lacrimal glands are paired almond-shaped glands, located in or near the orbital region, that secrete the aqueous layer of the tear film.[WP].	MA:0001296|EFO:0001389|CALOHA:TS-0512|BTO:0000044|VHOG:0001476|EMAPA:35463|EV:0100339|UMLS:C0022907|FMA:59101|NCIT:C12346	hp.json	glandula lacrimalis|lacrimal-preorbital gland|preorbital gland|glandula praeorbitalis|tear gland	http://purl.obolibrary.org/obo/UBERON_0001817		pheno_slim|efo_slim|uberon_slim|organ_slim
UBERON:0001816	biolink:AnatomicalEntity	autonomic nerve plexus	A nerve plexus that is part of an autonomic nervous system [Automatically generated definition].	FMA:5910|EMAPA:18224|MA:0000221	hp.json	plexus nervosus visceralis|visceral nerve plexus|plexus autonomicus|autonomic plexus|visceral plexus|plexus visceralis	http://purl.obolibrary.org/obo/UBERON_0001816		
UBERON:0001811	biolink:AnatomicalEntity	conjunctiva	The mucous membrane that lines the inner surface of the eyelids and the front of the eyeball.	XAO:0000182|NCIT:C12341|EV:0100340|EFO:0000374|GAID:898|CALOHA:TS-2232|UMLS:C0009758|MESH:D003228|FMA:59011|EMAPA:18233|MA:0000265|BTO:0003415|AAO:0010343	hp.json	conjunctivas|wall of conjunctival sac|tunica conjunctiva|conjunctivae	http://purl.obolibrary.org/obo/UBERON_0001811		efo_slim|uberon_slim|pheno_slim
UBERON:0001810	biolink:AnatomicalEntity	nerve plexus	Anatomical junction where subdivisions of two or more neural trees interconnect with one another to form a network through which nerve fibers of the constituent nerve trees become regrouped; together with other nerve plexuses, nerves and ganglia, it constitutes the peripheral nervous system. Examples: cervical nerve plexus, brachial nerve plexus, sacral nerve plexus[FMA].	NCIT:C12929|EHDAA:3780|FMA:5901|MA:0002407|EMAPA:37683|UMLS:C0501403|BTO:0000205|EHDAA2:0003138|AEO:0000138	hp.json	plexus	http://purl.obolibrary.org/obo/UBERON_0001810		human_reference_atlas|uberon_slim
UBERON:0001813	biolink:AnatomicalEntity	spinal nerve plexus	An intermingling of fiber fascicles from adjacent spinal nerves to form a network.	FMA:5903|EMAPA:16987|EHDAA2:0001899|MA:0000235|VHOG:0000925|UMLS:C0228603|NCIT:C49601	hp.json	plexus of spinal nerves|spinal nerve plexus|somatic nerve plexus|plexus nervorum spinalium	http://purl.obolibrary.org/obo/UBERON_0001813		
UBERON:0001812	biolink:AnatomicalEntity	palpebral conjunctiva	A thin transparent mucous membrane that covers the posterior surface of the eyelids and is continuous with the bulbar conjunctiva at the conjunctival fornicies.	UMLS:C0229274|NCIT:C12901|FMA:59025|MA:0001265	hp.json	conjunctival layer of eyelids|tunica conjunctiva palpebrum|tarsal conjunctiva|eyelid conjunctiva	http://purl.obolibrary.org/obo/UBERON_0001812		pheno_slim
HP:0033611	biolink:PhenotypicFeature	Part-solid pulmonary nodule	Part-solid pulmonary nodules are nodules that present with both ground-glass and solid components in which the underlying lung architecture cannot be visualized.		hp.json		http://purl.obolibrary.org/obo/HP_0033611		
HP:0033610	biolink:PhenotypicFeature	Subsolid pulmonary nodule	Pulmonary subsolid nodules (SSNs) refer to pulmonary nodules with pure ground-glass nodules and part-solid ground-glass nodules. A ground-glass nodule (GGN) is the morphologic description of a pulmonary nodule category on thin-section chest computed tomography (CT). During the past decade, the natural history, management strategy and long-term prognosis in the case of GGNs have attracted attention.		hp.json		http://purl.obolibrary.org/obo/HP_0033610		
UBERON:0001819	biolink:AnatomicalEntity	palpebral fissure	Orifice separating upper and lower eyelids. In the human adult this measures about 10mm vertically and 30 mm horizontally. It can be reduced in size in fetal alcohol syndrome. In Trisomy 9 the palpebral fissures can be upslanting. [WP,modified].	FMA:59110|MA:0001266	hp.json	rima palpebrarum	http://purl.obolibrary.org/obo/UBERON_0001819		pheno_slim|uberon_slim
UBERON:0001818	biolink:AnatomicalEntity	tarsal gland	A modified lobulated sebaceous gland at the rim of an eyelid, responsible for the supply of meibum.	UMLS:C0025181|MESH:D008537|NCIT:C33075|GAID:899|FMA:59104|MA:0001249|BTO:0004165	hp.json	tarsoconjunctival gland|Meibomian gland|palpebral gland|gland of Meibom|glandula tarsales	http://purl.obolibrary.org/obo/UBERON_0001818		pheno_slim|uberon_slim|organ_slim
HP:0033617	biolink:PhenotypicFeature	Supernumerary tracheal bronchus	Accessory bronchus which exits the trachea in addition to an anatomically normal branching upper lobe bronchus.		hp.json		http://purl.obolibrary.org/obo/HP_0033617		
HP:0033616	biolink:PhenotypicFeature	Accessory cardiac bronchus	Accessory bronchus originating from the medial wall of the right or left ban bronchus or bronchus intermedius. A cardiac bronchus is usually blind-ended.		hp.json		http://purl.obolibrary.org/obo/HP_0033616		
HP:0033619	biolink:PhenotypicFeature	Typical perifissural nodule	A perifissural nodule that has contact with the interlobar septum (and is therefore considered typical).		hp.json		http://purl.obolibrary.org/obo/HP_0033619		
HP:0033618	biolink:PhenotypicFeature	Displaced lobar tracheal bronchus	Accessory entire right upper lobe bronchial system originating from the trachea with absent anatomically normal upper lobe bronchus.		hp.json	Bronchus suis|Pig bronchus	http://purl.obolibrary.org/obo/HP_0033618		
HP:0033613	biolink:PhenotypicFeature	Perifissural pulmonary nodule	Solid, homogenous nodules characterised by a smooth margin and oval, rounded, lentiform or triangular shape. They are typically located within 15 mm from the issue or the pleura. Perifissural nodules may be further differentiated into typical (have contact with interlobar septum) and atypical (do not have contact with interlobar septum). They likely represent intrapulmonary lymphnodes.		hp.json		http://purl.obolibrary.org/obo/HP_0033613		
HP:0033612	biolink:PhenotypicFeature	Pure ground-glass pulmonary nodule	Pure ground-glass pulmonary nodules (GGNs) are defined as focal nodular areas of increased lung attenuation through which lung parenchymal structures, such as the pulmonary vessels or bronchial structures, can be observed.		hp.json		http://purl.obolibrary.org/obo/HP_0033612		
CHEBI:131565	biolink:ChemicalSubstance	steroid aldehyde	Any steroid substituted by a formyl group.		hp.json	steroid aldehydes	http://purl.obolibrary.org/obo/CHEBI_131565		3_STAR
HP:0008648	biolink:PhenotypicFeature	Anteriorly displaced urethral meatus		UMLS:C4024648	hp.json		http://purl.obolibrary.org/obo/HP_0008648		
HP:0033615	biolink:PhenotypicFeature	Displaced tracheal bronchus	Accessory bronchus originating from trachea replacing one of the segmental branches of the anatomically normal upper lobe bronchus.		hp.json		http://purl.obolibrary.org/obo/HP_0033615		
HP:0008647	biolink:PhenotypicFeature	Pubertal developmental failure in females		UMLS:C4024649	hp.json		http://purl.obolibrary.org/obo/HP_0008647		
HP:0033614	biolink:PhenotypicFeature	Tracheal bronchus	Aberrant or accessory bronchus supplying the upper lobe originating from the lateral wall of the trachea. The tracheal bronchus is more commonly right-sided, has a variable length and may be blind-ended. Two common types of tracheal bronchus are: supernumerary and displaced.		hp.json		http://purl.obolibrary.org/obo/HP_0033614		
GO:0036504	biolink:BiologicalProcess	Golgi membrane fusion	The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane.		hp.json	membrane fusion involved in Golgi reassembly|post-mitotic fusion of Golgi membranes	http://purl.obolibrary.org/obo/GO_0036504		
UBERON:0001820	biolink:AnatomicalEntity	sweat gland	Any of the coil glands of the skin that secrete sweat.	VHOG:0001467|OpenCyc:Mx4rvVjx15wpEbGdrcN5Y29ycA|GAID:943|BTO:0001331|EV:0100160|CALOHA:TS-0993|NCIT:C33712|MESH:D013545|UMLS:C0038989|FMA:59152|EMAPA:35844|MA:0000150	hp.json	glandula sudorifera|sudoriparous gland|sudoriferous gland	http://purl.obolibrary.org/obo/UBERON_0001820		uberon_slim|organ_slim|pheno_slim
HP:0008643	biolink:PhenotypicFeature	Nephroblastomatosis	Presence of persistent islands of renal blastema in the postnatal kidney. Nephroblastomatosis represents a complex abnormality of nephrogenesis and has been defined as the persistence of metanephricblastema into infancy and childhood.	UMLS:C2675558	hp.json		http://purl.obolibrary.org/obo/HP_0008643		
HP:0008640	biolink:PhenotypicFeature	Congenital macroorchidism		UMLS:C4024650	hp.json		http://purl.obolibrary.org/obo/HP_0008640		
UBERON:0001804	biolink:AnatomicalEntity	capsule of lens	The elastic, clear, membrane-like structure, that is outer most layer of the lens.	ZFA:0005574|Wikipedia:Lens_(anatomy)#Lens_capsule|SCTID:244500004|UMLS:C0229232|VHOG:0000550|EHDAA2:0000977|NCIT:C32975|EMAPA:18237|FMA:58881|MA:0001300	hp.json	lens capsule|capsula lentis	http://purl.obolibrary.org/obo/UBERON_0001804		pheno_slim|uberon_slim|vertebrate_core
UBERON:0001803	biolink:AnatomicalEntity	epithelium of lens	A layer of epithelial cells that is part of the eye.	BTO:0001873|SCTID:362523006|EMAPA:32871|XAO:0004094|CALOHA:TS-0543|ZFA:0001326|FMA:58871|Wikipedia:Lens_(anatomy)#Lens_Epithelium|TAO:0001326|MA:0001301	hp.json	epithelium lentis|lens epithelium|lens epithelial tissue|eye lens epithelial tissue|epithelial tissue of lens|epithelial tissue of eye lens|epithelium of eye lens|eye lens epithelium	http://purl.obolibrary.org/obo/UBERON_0001803		pheno_slim|human_reference_atlas|vertebrate_core
UBERON:0001806	biolink:AnatomicalEntity	sympathetic ganglion	A ganglion of the sympathetic nervous system. Examples: paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.	NCIT:C12467|FMA:5890|AAO:0010773|SCTID:362485003|BTO:0001333|EHDAA2:0001969|CALOHA:TS-0994|UMLS:C0017071|MA:0000226|MESH:D005728|EMAPA:17157|Wikipedia:Sympathetic_ganglion	hp.json	ganglion of sympathetic part of autonomic division of nervous system|ganglion sympatheticum|sympathetic nervous system ganglion|ganglion sympathicum|ganglion sympathicum|ganglion of sympathetic nervous system|ganglion sympathicum|sympathetic part of autonomic division of nervous system ganglion	http://purl.obolibrary.org/obo/UBERON_0001806		pheno_slim|uberon_slim
UBERON:0001805	biolink:AnatomicalEntity	autonomic ganglion	Ganglion that has dendrites that form a junction between autonomic nerves originating from the central nervous system and autonomic nerves innervating their target organs in the periphery. There are two subtypes, sympathetic ganglion and parasympathetic ganglion.	EMAPA:18221|MA:0000220|Wikipedia:Autonomic_ganglion|UMLS:C0017068|FMA:5889|AEO:0001001|EMAPA:17157|MESH:D005725|CALOHA:TS-2340|NCIT:C12720	hp.json	ganglion of visceral nervous system|autonomic nervous system ganglion|ganglion autonomicum|ganglion autonomicum|ganglion of autonomic nervous system|visceral nervous system ganglion	http://purl.obolibrary.org/obo/UBERON_0001805		uberon_slim
UBERON:0001800	biolink:AnatomicalEntity	sensory ganglion	The clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells.	MESH:D017950|BTO:0005630|FMA:5885|AEO:0001000|NCIT:C13060|EMAPA:36596|MA:0002566|UMLS:C0206429	hp.json	ganglion sensorium	http://purl.obolibrary.org/obo/UBERON_0001800		pheno_slim
UBERON:0001802	biolink:AnatomicalEntity	posterior segment of eyeball	Any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive).	MA:0002485|Wikipedia:Posterior_segment_of_eyeball|FMA:58868|NCIT:C12906|UMLS:C0278450|SCTID:280659009|EMAPA:36595|ZFA:0005567	hp.json	posterior segment eye|segmentum posterius (bulbus oculi)|posterior segment of the eye|posterior segment of eye|eye posterior segment|posterior eye segment|segmentum posterius bulbi oculi|segmentum posterius bulbi oculi	http://purl.obolibrary.org/obo/UBERON_0001802		pheno_slim|vertebrate_core
UBERON:0001801	biolink:AnatomicalEntity	anterior segment of eyeball	Any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive).	Wikipedia:Anterior_segment_of_eyeball|MA:0002484|SCTID:280658001|FMA:58865|MESH:D000869|UMLS:C0003153|NCIT:C12668|EMAPA:36594|ZFA:0005566	hp.json	eye anterior segment|segmentum anterius bulbi oculi|segmentum anterius (bulbus oculi)|anterior segment eye|anterior segment of the eye|anterior segment of eye|segmentum anterius bulbi oculi|anterior eye segment	http://purl.obolibrary.org/obo/UBERON_0001801		pheno_slim|vertebrate_core
HP:0033620	biolink:PhenotypicFeature	Atypical perifissural nodule	A perifissural nodule that does not have contact with the interlobar septum (and is therefore considered atypical).		hp.json		http://purl.obolibrary.org/obo/HP_0033620		
HP:0033622	biolink:PhenotypicFeature	Migratory erythematous plaque	A migratory, centrifugal, erythematous, tender, non-purpuric, and well-demarcated plaque. This feature may be observed in TNF receptor-associated periodic syndrome, in which it often occurs together with migratory myalgia in muscles located underneath the affected areas of skin.		hp.json		http://purl.obolibrary.org/obo/HP_0033622		
HP:0033621	biolink:PhenotypicFeature	Bronchial diverticula	Bronchial diverticula are blind-ended outpouchings arising from the bronchial tree. They are commonly pulsion diverticula acquired related to chronic cough. Subcarinal air cyst is thought to represent a small main bronchial diverticulum.		hp.json		http://purl.obolibrary.org/obo/HP_0033621		
UBERON:0001808	biolink:AnatomicalEntity	parasympathetic ganglion	Ganglion containing neurons that receive innervation from parasympathetic neurons in the central nervous system and subserves parasympathetic functions through innervation of smooth muscle, cardiac muscle and glands.	Wikipedia:Parasympathetic_ganglion|EMAPA:32813|EHDAA2:0001400|UMLS:C0017069|NLXANAT:100303|BTO:0001256|NCIT:C52557|MA:0002469|SCTID:279284004|FMA:5894|MESH:D005726	hp.json	ganglion parasympathicum|ganglion parasympathicum|ganglion parasympathicum	http://purl.obolibrary.org/obo/UBERON_0001808		pheno_slim|uberon_slim
UBERON:0001809	biolink:AnatomicalEntity	enteric ganglion		MA:0001144|NCIT:C52709|UMLS:C0501399|EMAPA:35312|FMA:5896	hp.json	intramural ganglion	http://purl.obolibrary.org/obo/UBERON_0001809		pheno_slim
HP:0033628	biolink:PhenotypicFeature	Bowel irritability	Intermittent abdominal pain with diarrhea and/or constipation.		hp.json		http://purl.obolibrary.org/obo/HP_0033628		
HP:0033627	biolink:PhenotypicFeature	Increased urine harderoporphyrin level	Increased amount of harderoporphyrin in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033627		
HP:0008619	biolink:PhenotypicFeature	Bilateral sensorineural hearing impairment	A bilateral form of sensorineural hearing impairment.	SNOMEDCT_US:194424005|UMLS:C0452138	hp.json	Bilateral nerve deafness|Bilateral sensorineural hearing loss|Hearing loss, sensorineural, bilateral|Bilateral sensorineural deafness	http://purl.obolibrary.org/obo/HP_0008619		
HP:0033629	biolink:PhenotypicFeature	IgG4 autoimmune antibody positivity	The presence of an antibody of subclass IgG4 in the blood circulation that is directed against the organism's own cells or tissues.		hp.json		http://purl.obolibrary.org/obo/HP_0033629		
HP:0033624	biolink:PhenotypicFeature	History of congenital CMV infection	A congenital cytomegalovirus (CMV) infection of the newborn can follow either a primary or recurrent maternal infection. Jaundice, petechiae, and hepatosplenomegaly are the most frequently noted clinical triad in symptomatic infants. Affected infants may develop permanent disabilities such as hearing loss, vision loss, motor and cognitive deficits.		hp.json	History of congenital cytomegalovirus infection	http://purl.obolibrary.org/obo/HP_0033624		
HP:0033623	biolink:PhenotypicFeature	Birth history	Information about the delivery and health status at birth typically elicited as a part of the past medical history.		hp.json		http://purl.obolibrary.org/obo/HP_0033623		
HP:0033626	biolink:PhenotypicFeature	Increased non-HDL cholesterol concentration	Increase above normal levels of non-HDL cholesterol in the blood. Non-HDL cholesterol is total cholesterol minus high-density lipoprotein HDL-cholesterol (high-density lipoprotein-cholesterol).		hp.json	Elevated non-HDL cholesterol concentration	http://purl.obolibrary.org/obo/HP_0033626		
HP:0008615	biolink:PhenotypicFeature	Adult onset sensorineural hearing impairment	The presence of sensorineural deafness with late onset.	UMLS:C4021534	hp.json	Sensorineural deafness, late-onset|Late sensorineural hearing loss	http://purl.obolibrary.org/obo/HP_0008615		
HP:0033625	biolink:PhenotypicFeature	Emotional insecurity	A feeling of general unease or nervousness that may be triggered by a sense of vulnerability or instability which is perceived as threatening.		hp.json		http://purl.obolibrary.org/obo/HP_0033625		
HP:0008610	biolink:PhenotypicFeature	Infantile sensorineural hearing impairment	A form of sensorineural hearing impairment with infantile onset.	UMLS:C4021535	hp.json	Infantile sensorineural hearing loss	http://purl.obolibrary.org/obo/HP_0008610		
HP:0033631	biolink:PhenotypicFeature	Spondylitis	Inflammation of the vertebrae (vertebral bodies) or spine.		hp.json		http://purl.obolibrary.org/obo/HP_0033631		
HP:0033630	biolink:PhenotypicFeature	Brain fog	Brain fog is a type of transient cognitive dysfunction that comprises a constellation of symptoms that impair intellectual functioning to a level that interferes with daily activities, commonly including forgetfulness, mental slowness, difficulty thinking or focusing, a perceived slowing of mental processing speed, inability to find the right words, a sensation that the mind went blank or is "cloudy". Brain fog tends to recur and may be triggered by factors such as physical fatigue, lack of sleep, and prolonged standing or may appear to occur spontaneously.		hp.json	Mental fog|Mental clouding|Mental fatigue	http://purl.obolibrary.org/obo/HP_0033630		
HP:0033633	biolink:PhenotypicFeature	Decreased alveolar volume	An abnormal reduction in alveolar volume.		hp.json		http://purl.obolibrary.org/obo/HP_0033633		
HP:0033632	biolink:PhenotypicFeature	Abnormal alveolar volume	Alveolar volume (VA) is a volume accessible during 10-second breath-hold, measured during a single breath manouver. VA is calculated by knowing the fractional concentration of the tracer gas (eg helium) and the volume of the gas inhaled. VA = Vi*(Fi tracer/Fa tracer). In this equation, Vi = inspired volume of tracer gas, Fi tracer= inspired fraction of tracer gas, Fa tracer = alveolar (exhaled) fraction of tracer gas.		hp.json		http://purl.obolibrary.org/obo/HP_0033632		
HP:0008628	biolink:PhenotypicFeature	Abnormality of the stapes	An abnormality of the stapes, a stirrup-shaped ossicle in the middle ear.	UMLS:C4021532	hp.json	Stapedial abnormalities	http://purl.obolibrary.org/obo/HP_0008628		
HP:0033639	biolink:PhenotypicFeature	Septic pulmonary embolism	Embolization of intravascular thrombus containing microorganisms into the pulmonary parenchyma via arterial system. Septic pulmonary embolism (PE) can be associated with multiple additional clinical manifestations such as fever, tachypnea, and hemoptysis. This HPO term refers to the finding of the septic embolus in the lung, which can be inferred from radiological findings. Typical radiographic features of septic PE include patchy air space lesions simulating non-specific bronchopneumonia; multiple ill defined round or wedge shaped densities of varying sizes from approximately 0.5 to 3.5 cm located peripherally; lesions abutting the pleura and located at the end of vessels (feeding vessel sign) seen on chest CT scans. Other pulmonary features suggesting septic PE include bilateral, occasional unilateral, rapid progression of cavities or abscess formations.		hp.json	Septic pulmonary emboli	http://purl.obolibrary.org/obo/HP_0033639		
HP:0033638	biolink:PhenotypicFeature	Intralobular septal thickening	Intralobular septal thickening is a computed tomography finding of increased width of the walls (septa) within a pulmonary lobule. Secondary pulmonary lobules represent a cluster of up to 30 acini 9 supplied by a common distal pulmonary artery and bronchiole. These clustered acini are bounded by interstitial fibrous septa (interlobular septa) which outline an irregular polyhedron of varying size between 1 and 2.5 cm. Interlobular septal thickening is seen on chest radiographs as thin linear opacities at right angles to and in contact with the lateral pleural surfaces near the lung bases. In contrast, intralobular septal thickening are visible as fine linear opacities in a lobule when the intralobular interstitial tissue is abnormally thickened. When numerous, they may appear as a fine reticular pattern.		hp.json	Intralobular lines	http://purl.obolibrary.org/obo/HP_0033638		
HP:0008629	biolink:PhenotypicFeature	Pulsatile tinnitus	Pulsatile tinnitus is generally classified a kind of objective tinnitus, meaning that it is not only audible to the patient but also to the examiner on auscultation of the auditory canal and/or of surrounding structures with use of an auscultation tube or stethoscope. Usually, pulsatile tinnitus is heard as a lower pitched thumping or booming, a rougher blowing sound which is coincidental with respiration, or as a clicking, higher pitched rhythmic sensation.	SNOMEDCT_US:232322006|UMLS:C0751559|MSH:D014012	hp.json		http://purl.obolibrary.org/obo/HP_0008629		
HP:0033635	biolink:PhenotypicFeature	Post-capillary pulmonary hypertension	Post-capillary pulmonary hypertension is a hemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP greater than 20 mmHg) and pulmonary artery wedge pressure (PAWP greater than 15 mmHg) and pulmonary vascular resistance (PVR less than 3 Wood units).		hp.json	Postcapillary pulmonary hypertension	http://purl.obolibrary.org/obo/HP_0033635		
HP:0033634	biolink:PhenotypicFeature	Increased alveolar volume	An abnormal elevation in alveolar volume.		hp.json		http://purl.obolibrary.org/obo/HP_0033634		
HP:0033637	biolink:PhenotypicFeature	Anti-endomysial antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against endomysial tissue transglutaminase 2 (tTG2).		hp.json	Anti-transglutaminase 2 antibody positivity	http://purl.obolibrary.org/obo/HP_0033637		
HP:0033636	biolink:PhenotypicFeature	Combined pre- and post-capillary pulmonary hypertension	Combined pre- and post-capillary pulmonary hypertension is a haemodynamic condition characterised by elevated mean pulmonary artery pressure (mPAP over 20 mmHg) and pulmonary artery wedge pressure (PAWP over 15 mmHg) and pulmonary vascular resistance (PVR at least 3 Wodd units).		hp.json		http://purl.obolibrary.org/obo/HP_0033636		
HP:0008625	biolink:PhenotypicFeature	Severe sensorineural hearing impairment	A severe form of sensorineural hearing impairment.	UMLS:C4021533	hp.json	Severe sensorineural deafness|Severe sensorineural hearing loss	http://purl.obolibrary.org/obo/HP_0008625		
CHEBI:36299	biolink:ChemicalSubstance	tricarboxylic acid monoanion			hp.json	tricarboxylic acid monoanions	http://purl.obolibrary.org/obo/CHEBI_36299		3_STAR
UBERON:0001869	biolink:AnatomicalEntity	cerebral hemisphere	One of two bilateral, largely symmetrical organ subdivisions within the telencephalon which contain the cerebral cortex and cerebral white matter.[FMA].	SCTID:278251007|EMAPA:16653|UMLS:C0228174|MA:0000133|BIRNLEX:1042|BAMS:HEM|OpenCyc:Mx4rvigx5ZwpEbGdrcN5Y29ycA|VHOG:0001639|MBA:403|DMBA:15739|EFO:0002521|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=241|galen:CerebralHemisphere|NCIT:C12351|CALOHA:TS-2007|FMA:61817|BTO:0000231|Wikipedia:Cerebral_hemisphere|AAO:0010480|UMLS:C0242202	hp.json	nucleus medialis amygdalae|hemispherium cerebri|cerebrum|medial amygdalar nucleus|hemispherium cerebri|nucleus amygdaloideus medialis|hemispheric regions|cerebrum|hemisphere	http://purl.obolibrary.org/obo/UBERON_0001869		uberon_slim|pheno_slim|efo_slim
UBERON:0001866	biolink:AnatomicalEntity	sebum	Fatty lubricant matter secreted by sebaceous glands, and made of made of triglyceride oils, wax, squalene, and metabolytes of fat-producing cells[BTO,WP].	ENVO:02000037|FMA:61304|GAID:1168|UMLS:C0036511|NCIT:C13276|BTO:0001981|MESH:D012629|MA:0002538	hp.json		http://purl.obolibrary.org/obo/UBERON_0001866		uberon_slim
UBERON:0001868	biolink:AnatomicalEntity	skin of chest	A zone of skin that is part of a chest [Automatically generated definition].	FMA:61416|MA:0000553|EMAPA:37279	hp.json	chest zone of skin|zone of skin of pectoral part of chest|chest skin|zone of skin of anterior part of thorax|zone of skin of anterolateral part of thorax|anterior thoracic region zone of skin|zone of skin of anterior chest|zone of skin of chest|zone of skin of front of thorax|anterolateral part of thorax zone of skin|zone of skin of anterior thoracic region|front of thorax zone of skin	http://purl.obolibrary.org/obo/UBERON_0001868		pheno_slim
UBERON:0001867	biolink:AnatomicalEntity	cartilage of external ear	A cartilage that is part of a external ear [Automatically generated definition].	EMAPA:37706|GAID:103|MA:0001886|FMA:61339|MESH:D004425|UMLS:C0013445|NCIT:C49225	hp.json	external ear cartilage	http://purl.obolibrary.org/obo/UBERON_0001867		pheno_slim
GO:0012505	biolink:CellularComponent	endomembrane system	A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.	Wikipedia:Endomembrane_system	hp.json		http://purl.obolibrary.org/obo/GO_0012505		goslim_yeast|goslim_candida|goslim_flybase_ribbon|goslim_aspergillus
GO:0012506	biolink:CellularComponent	vesicle membrane	The lipid bilayer surrounding any membrane-bounded vesicle in the cell.	NIF_Subcellular:sao1153182838	hp.json		http://purl.obolibrary.org/obo/GO_0012506		
CHEBI:24281	biolink:ChemicalSubstance	glucosyl group	A glycosyl group obtained by removing the hydroxy group from the hemiacetal function of a glucose and, by extension, of a lower oligosaccharide having glucose at the reducing end.		hp.json	glucosyl groups	http://purl.obolibrary.org/obo/CHEBI_24281		3_STAR
CHEBI:24280	biolink:ChemicalSubstance	D-glucosyl group	The glucosyl group formed from D-glucopyranose.		hp.json	glucopyranosyl group|D-glucopyranosyl|D-glucopyranosyl group|glucosyl group	http://purl.obolibrary.org/obo/CHEBI_24280		3_STAR
GO:0012501	biolink:BiologicalProcess	programmed cell death	A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.	Wikipedia:Programmed_cell_death	hp.json	PCD|nonapoptotic programmed cell death|non-apoptotic programmed cell death|caspase-independent cell death|caspase-independent apoptosis|RCD|regulated cell death	http://purl.obolibrary.org/obo/GO_0012501		prokaryote_subset|goslim_generic
HP:0006016	biolink:PhenotypicFeature	Delayed phalangeal epiphyseal ossification	Delay in the process of formation and maturation of the epiphysis of one or more phalanx.	UMLS:C4021609	hp.json	Delayed bone maturation of end part of digital bone|Delayed phalangeal epiphyseal bone maturation	http://purl.obolibrary.org/obo/HP_0006016		
HP:0008678	biolink:PhenotypicFeature	Renal hypoplasia/aplasia	Absence or underdevelopment of the kidney.	UMLS:C1857453	hp.json	Absent/underdeveloped kidney|Renal aplasia/hypoplasia|Absent/small kidney|Renal agenesis/hypoplasia	http://purl.obolibrary.org/obo/HP_0008678		
HP:0006019	biolink:PhenotypicFeature	Reduced proximal interphalangeal joint space		UMLS:C1861396	hp.json	Decreased space in hinge joint	http://purl.obolibrary.org/obo/HP_0006019		
UBERON:0001873	biolink:AnatomicalEntity	caudate nucleus	Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species.	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=226|BIRNLEX:1373|UMLS:C0007461|GAID:670|OpenCyc:Mx4rvvyAjJwpEbGdrcN5Y29ycA|MESH:D002421|NCIT:C12451|BAMS:Cd|UMLS:C0007461|BTO:0000211|EV:0100185|EFO:0000907|BAMS:CA|HBA:4278|EHDAA2:0004461|EMAPA:18207|DMBA:15855|PBA:10082|BM:Tel-CA|CALOHA:TS-0121|DHBA:10334|MAT:0000513|FMA:61833|MA:0000894	hp.json	nucleus caudatus|nucleus caudatus|Ammon horn fields|caudatum|caudatus	http://purl.obolibrary.org/obo/UBERON_0001873		pheno_slim|efo_slim|uberon_slim
HP:0008675	biolink:PhenotypicFeature	Enlarged polycystic ovaries		UMLS:C4024641	hp.json	Enlarged ovaries with cysts	http://purl.obolibrary.org/obo/HP_0008675		
HP:0006012	biolink:PhenotypicFeature	Widened metacarpal shaft		UMLS:C1850159	hp.json	Broad shaft of long bone of hand	http://purl.obolibrary.org/obo/HP_0006012		
UBERON:0001872	biolink:AnatomicalEntity	parietal lobe	Upper central part of the cerebral hemisphere. (MSH).	HBA:4084|UMLS:C0030560|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=95|EV:0100168|GAID:680|UMLS:C0030560|CALOHA:TS-0747|NCIT:C12354|DHBA:12131|MESH:D010296|BTO:0001001|BIRNLEX:1148|OpenCyc:Mx4rvg-typwpEbGdrcN5Y29ycA|FMA:61826|MAT:0000506|EFO:0000914|BAMS:Parietal_lobe	hp.json	regio parietalis|parietal region|lobus parietalis	http://purl.obolibrary.org/obo/UBERON_0001872		pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0001875	biolink:AnatomicalEntity	globus pallidus	Subcortical nucleus, functionally part of the basal ganglia, which consists of two segments the external (or lateral) and internal (or medial) separated by the medial medullary lamina in primates. In rodents, The globus pallidus lateral is separated from the medial segment by the fibers of the internal capsule/cerebral peduncle.	HBA:4293|DHBA:10342|MAT:0000510|EMAPA:35380|MA:0000890|EV:0100188|UMLS:C0017651|UMLS:C0017651|BTO:0002246|PBA:10097|GAID:668|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=231|EFO:0000905|MESH:D005917|BIRNLEX:1234|NCIT:C12449|FMA:61835|CALOHA:TS-2013|BAMS:GP	hp.json	globus pallidus (Burdach)|pale body|paleostriatum|pallidum|pallidium|nucleus pallidus	http://purl.obolibrary.org/obo/UBERON_0001875		pheno_slim|efo_slim|uberon_slim
HP:0008677	biolink:PhenotypicFeature	Congenital nephrotic syndrome	Nephrotic syndrome with onset within the first three months of life.	MSH:C535761|UMLS:C3501848|SNOMEDCT_US:48796009	hp.json	Congenital nephrosis	http://purl.obolibrary.org/obo/HP_0008677		
HP:0006014	biolink:PhenotypicFeature	Abnormally shaped carpal bones		UMLS:C1860111	hp.json	Abnormally shaped wrist bones	http://purl.obolibrary.org/obo/HP_0006014		
HP:0008676	biolink:PhenotypicFeature	Congenital megaureter	A developmental disturbance with extreme ureteral dilatation.	UMLS:C0266324|SNOMEDCT_US:718485003|SNOMEDCT_US:95576001	hp.json	Congenital megaloureter	http://purl.obolibrary.org/obo/HP_0008676		
UBERON:0001874	biolink:AnatomicalEntity	putamen	Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion.	UMLS:C0034169|GAID:671|BAMS:PU|BAMS:Pu|CALOHA:TS-2041|NCIT:C12452|EV:0100187|BM:Tel-Pu|DMBA:15857|VHOG:0001456|PBA:10086|BIRNLEX:809|DHBA:10338|HBA:4287|FMA:61834|MA:0000895|EMAPA:35719|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=230|MESH:D011699	hp.json	nucleus putamen	http://purl.obolibrary.org/obo/UBERON_0001874		pheno_slim|human_reference_atlas|uberon_slim
HP:0008670	biolink:PhenotypicFeature	Partial vaginal septum		UMLS:C0750088	hp.json		http://purl.obolibrary.org/obo/HP_0008670		
UBERON:0001871	biolink:AnatomicalEntity	temporal lobe	Lower lateral part of the cerebral hemisphere. (MSH).	UMLS:C0039485|CALOHA:TS-1020|EV:0100169|BIRNLEX:1160|NCIT:C12353|UMLS:C1268978|OpenCyc:Mx4rwQLi-ZwpEbGdrcN5Y29ycA|BTO:0001355|UMLS:C0039485|MAT:0000508|EFO:0000917|GAID:635|FMA:61825|HBA:4132|DHBA:12139|MESH:D013702|BAMS:Temporal_lobe|EMAPA:18797|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=125|BAMS:TL	hp.json	lobus temporalis|temporal cortex	http://purl.obolibrary.org/obo/UBERON_0001871		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0001870	biolink:AnatomicalEntity	frontal cortex	Anterior portion of the neocortex, lying anterior to the central sulcus in humans. It is bounded by the parietal cortex posteriorly and the temporal cortex laterally[NIFSTD,modified].	DMBA:16002|MA:0000905|DHBA:10161|BTO:0000484|EMAPA:35357|FMA:242199|GAID:674|NLXANAT:20090601	hp.json	gray matter of frontal lobe|frontal neocortex|frontal lobe cortex|grey matter of frontal lobe|cortex of frontal lobe	http://purl.obolibrary.org/obo/UBERON_0001870		pheno_slim|efo_slim|uberon_slim
HP:0008672	biolink:PhenotypicFeature	Calcium oxalate nephrolithiasis	The presence of calcium- and oxalate-containing calculi (stones) in the kidneys.	SNOMEDCT_US:444717006|UMLS:C1833683|UMLS:C4280806|MSH:C563477	hp.json	Ca2+ oxalate nephrolithiasis|Ca2+ oxalate urolithiasis|Oxalate nephrolithiasis|Ca2+ oxalate kidney stone|Calcium oxalate kidney stones|Calcium oxalate urolithiasis|Ca oxalate urolithiasis|Ca oxalate kidney stone|Ca oxalate nephrolithiasis	http://purl.obolibrary.org/obo/HP_0008672		
HP:0006011	biolink:PhenotypicFeature	Cuboidal metacarpal	Severely shortened metacarpal with a cuboidal appearance.	UMLS:C4025093	hp.json	Short, cube shaped long bone of hand	http://purl.obolibrary.org/obo/HP_0006011		
HP:0008691	biolink:PhenotypicFeature	Solitary bladder diverticulum	Presence of a single diverticulum (sac or pouch) in the wall of the urinary bladder.	UMLS:C4024639	hp.json		http://purl.obolibrary.org/obo/HP_0008691		
UBERON:0001855	biolink:AnatomicalEntity	cochlear duct of membranous labyrinth	An endolymph filled cavity inside the cochlea, located in between the scala tympani and the scala vestibuli, separated by the basilar membrane and Reissner's membrane (the vestibular membrane) respectively. Houses the organ of Corti[WP].	BTO:0001692|GAID:874|EMAPA:17598|FMA:61119|NCIT:C32335|BIRNLEX:2562|VHOG:0000507|CALOHA:TS-0152|MA:0000243|UMLS:C1323110|EHDAA2:0000262|UMLS:C1323110|EHDAA:4718|UMLS:C1281166|MESH:D003053	hp.json	cochlear aqueduct|scala of Loewenberg|cochlea duct|Reissner's canal|scala media|ductus cochlearis|scala medias|membranous cochlea|Reissners canal|ductus cochlearis|cochlear duct	http://purl.obolibrary.org/obo/UBERON_0001855		uberon_slim|pheno_slim
CHEBI:36278	biolink:ChemicalSubstance	cholanic acids			hp.json		http://purl.obolibrary.org/obo/CHEBI_36278		1_STAR
HP:0008689	biolink:PhenotypicFeature	Bilateral cryptorchidism	Absence of both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum.	SNOMEDCT_US:268228006|UMLS:C0431663|MSH:D003456	hp.json	Cryptorchidism, bilateral	http://purl.obolibrary.org/obo/HP_0008689		
HP:0006028	biolink:PhenotypicFeature	Metaphyseal cupping of metacarpals	Metaphyseal cupping affecting the metacarpal bones.	UMLS:C1855171	hp.json	Cupping of wide portion of long bone of hand|Metacarpal/metaphyseal cupping	http://purl.obolibrary.org/obo/HP_0006028		
UBERON:0001862	biolink:AnatomicalEntity	vestibular labyrinth	The part of the membranous labyrinth that includes the utricle and saccule lodged within the vestibule and the semicircular ducts lodged eccentrically in the corresponding canals.	MA:0000245|MESH:D014722|BTO:0001856|EMAPA:17286|XAO:0004145|NCIT:C33871|FMA:61255|EMAPA:17815|CALOHA:TS-0479|EHDAA:4706|UMLS:C0042606|EHDAA2:0000832	hp.json	vestibular apparatus|inner ear vestibular component|vestibular component|labyrinthus vestibularis	http://purl.obolibrary.org/obo/UBERON_0001862		pheno_slim
HP:0008687	biolink:PhenotypicFeature	Hypoplasia of the prostate		UMLS:C1844923	hp.json	Underdeveloped prostate|Hypoplastic prostate	http://purl.obolibrary.org/obo/HP_0008687		
HP:0006026	biolink:PhenotypicFeature	Rounded epiphyses		UMLS:C1850632	hp.json	Rounded end part of bone	http://purl.obolibrary.org/obo/HP_0006026		
HP:0008682	biolink:PhenotypicFeature	Renal tubular epithelial necrosis	Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%).	SNOMEDCT_US:35455006|UMLS:C0022672|MSH:D007683	hp.json	Acute tubular necrosis|Renal tubular necrosis	http://purl.obolibrary.org/obo/HP_0008682		
CHEBI:36277	biolink:ChemicalSubstance	bile acid salt			hp.json		http://purl.obolibrary.org/obo/CHEBI_36277		
HP:0008684	biolink:PhenotypicFeature	Aplasia/hypoplasia of the uterus	Absence or developmental hypoplasia of the uterus.	UMLS:C4024640	hp.json	Absent/underdeveloped uterus|Absent/small uterus	http://purl.obolibrary.org/obo/HP_0008684		
HP:0008683	biolink:PhenotypicFeature	Enlarged labia minora	Increase in size of the folds of skin between the outer labia.	UMLS:C1849358	hp.json	Labia minora hypertrophy|Hypertrophic labia minora	http://purl.obolibrary.org/obo/HP_0008683		
UBERON:0001848	biolink:AnatomicalEntity	auricular cartilage	Cartilage of the pinna and much of the external ear canal.	EMAPA:35158|MA:0001227|FMA:61013	hp.json	pinna cartilage|cartilage of pinna	http://purl.obolibrary.org/obo/UBERON_0001848		pheno_slim
UBERON:0001847	biolink:AnatomicalEntity	lobule of pinna	The soft lower part of the external ear, projecting below the antitragus.	NCIT:C32999|UMLS:C0229315|MA:0002468|FMA:60984	hp.json	ear lobule|lobule of auricle of ear|lobule of auricle|lobulus auriculae|ear lobe|auricular lobule|earlobe|pinna lobule|lobe of ear	http://purl.obolibrary.org/obo/UBERON_0001847		uberon_slim|pheno_slim
UBERON:0001849	biolink:AnatomicalEntity	membranous labyrinth	Organ with organ cavity which consists of the vestibular labyrinth and the cochlear labyrinth. The membranous labyrinth is lodged within the bony labyrinth and has the same general form; it is, however, considerably smaller and is partly separated from the bony walls by a quantity of fluid, the perilymph.[FMA, WP].	AAO:0011060|EHDAA2:0000899|VHOG:0000729|NCIT:C33090|MA:0000242|EHDAA:4698|EV:0100367|UMLS:C0458700|XAO:0000194|EMAPA:17815|FMA:61022	hp.json	labyrinthus membranaceus	http://purl.obolibrary.org/obo/UBERON_0001849		uberon_slim|organ_slim|pheno_slim
UBERON:0001844	biolink:AnatomicalEntity	cochlea	The spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound. Its core component is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating fluid chambers in the coiled tapered tube of the cochlea. [WP,modified].	MESH:D003051|VHOG:0000691|OpenCyc:Mx4rvqfJmJwpEbGdrcN5Y29ycA|EMAPA:17597|ZFA:0000374|CALOHA:TS-0151|XAO:0000197|FMA:60201|EFO:0000357|UMLS:C0009195|MA:0000240|NIFSTD_RETIRED:birnlex_883|TAO:0000374|MAT:0000144|UMLS:C0009195|BTO:0000267|EV:0100363|AAO:0000253|NCIT:C12395|BIRNLEX:1190|UMLS:C1278895|GAID:724|MIAA:0000144	hp.json	lagenas|cochlear organ|cochlear duct|cochleae|lagena|cochlear part of bony labyrinth	http://purl.obolibrary.org/obo/UBERON_0001844		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0001846	biolink:AnatomicalEntity	internal ear	Complex labyrinthine structure that comprises sensory endorgans specialized for vestibular, auditory, and acoustico-vestibular sensation.	ZFA:0000217|CALOHA:TS-0478|EFO:0001363|MA:0000237|TAO:0000217|EHDAA:504|UMLS:C1268973|galen:InnerEar|VHOG:0000284|EHDAA2:0000831|GAID:871|AAO:0000238|BIRNLEX:1196|MESH:D007758|NCIT:C12499|UMLS:C0022889|FMA:60909|MAT:0000145|OpenCyc:Mx4rwJ8SsJwpEbGdrcN5Y29ycA|EMAPA:16194|UMLS:C0022889|XAO:0000192|BTO:0000630|MIAA:0000145|EV:0100361	hp.json	auris interna|otocyst|inner ear|labyrinth	http://purl.obolibrary.org/obo/UBERON_0001846		uberon_slim|vertebrate_core|pheno_slim|efo_slim
CHEBI:24261	biolink:ChemicalSubstance	glucocorticoid	Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood.		hp.json	glucocorticoids	http://purl.obolibrary.org/obo/CHEBI_24261		3_STAR
CHEBI:36248	biolink:ChemicalSubstance	5beta-cholanic acids	Members of the class of cholanic acids based on a 5beta-cholane skeleton.		hp.json		http://purl.obolibrary.org/obo/CHEBI_36248		3_STAR
HP:0008656	biolink:PhenotypicFeature	Incomplete male pseudohermaphroditism		UMLS:C4024645	hp.json		http://purl.obolibrary.org/obo/HP_0008656		
HP:0008659	biolink:PhenotypicFeature	Multiple small medullary renal cysts	The presence of many cysts in the medulla of the kidney.	UMLS:C0687120|UMLS:C4024644|SNOMEDCT_US:204958008|UMLS:C4020790	hp.json	Medullary cystic disease|Medullary sponge kidney disease	http://purl.obolibrary.org/obo/HP_0008659		
UBERON:0001851	biolink:AnatomicalEntity	cortex	Outermost layer of an organ[WP].	FMA:61109|EHDAA:9344|EFO:0000383|galen:Cortex	hp.json	cortex of organ|cortex	http://purl.obolibrary.org/obo/UBERON_0001851		upper_level|pheno_slim|uberon_slim
HP:0008653	biolink:PhenotypicFeature	Crescentic glomerulonephritis	A type of extracapillary glomerulonephritis characterized by the formation of crescent-like cellular proliferation.	SNOMEDCT_US:236398000|UMLS:C0403416	hp.json		http://purl.obolibrary.org/obo/HP_0008653		
UBERON:0001850	biolink:AnatomicalEntity	lacrimal drainage system	A collection of channels that connects the conjunctival sac with the nasal cavity, encompassing the lacrimal ducts, the lacrimal sac and the naso-lacrimal duct.	EMAPA:19245|MA:0001295|FMA:61063	hp.json	lacrimal duct|tear duct	http://purl.obolibrary.org/obo/UBERON_0001850		pheno_slim|uberon_slim
HP:0008652	biolink:PhenotypicFeature	Autonomic erectile dysfunction	Impotence (inability to develop or maintain an erection) resulting from abnormal functioning of the autonomic nervous system.	UMLS:C1868524	hp.json	Impotence due to autonomic dysfunction	http://purl.obolibrary.org/obo/HP_0008652		
HP:0008655	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the fallopian tube	Aplasia or developmental hypoplasia of the fallopian tube.	UMLS:C4020791|UMLS:C4024646	hp.json	Absent or rudimentary fallopian tubes|Absent/underdeveloped fallopian tube|Absent/small fallopian tube	http://purl.obolibrary.org/obo/HP_0008655		
HP:0008651	biolink:PhenotypicFeature	Uric acid urolithiasis independent of gout		UMLS:C4024647	hp.json		http://purl.obolibrary.org/obo/HP_0008651		
CHEBI:36242	biolink:ChemicalSubstance	3-(4-hydroxyphenyl)pyruvate	A 2-oxo monocarboxylic acid anion obtained by removal of a proton from the carboxylic acid group of 3-(4-hydroxyphenyl)pyruvic acid.	Reaxys:3950858|Beilstein:3950858|KEGG:C01179|PMID:11948155|UM-BBD_compID:c0235|PMID:14593448	hp.json	3-(4-hydroxyphenyl)-2-oxopropanoate|4-Hydroxyphenylpyruvate|HPP|3-(4-hydroxyphenyl)pyruvate|3-(p-hydroxyphenyl)pyruvate|p-hydroxyphenylpyruvate|3-(4-Hydroxyphenyl)pyruvate	http://purl.obolibrary.org/obo/CHEBI_36242		3_STAR
UBERON:0001837	biolink:AnatomicalEntity	duct of salivary gland	The duct of a salivary gland.	BTO:0005115|EMAPA:35750|FMA:59908|MA:0001586|NCIT:C32486|GAID:939|MESH:D018987	hp.json	secretory duct|salivary duct|salivary gland duct	http://purl.obolibrary.org/obo/UBERON_0001837		uberon_slim|pheno_slim
UBERON:0001836	biolink:AnatomicalEntity	saliva	A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions.	NCIT:C13275|galen:Saliva|EMAPA:36536|MA:0002507|FMA:59862|CALOHA:TS-0891|OpenCyc:Mx4rvVjJ95wpEbGdrcN5Y29ycA|ENVO:02000036|UMLS:C0036087|MAT:0000444|MESH:D012463|GAID:1167|BTO:0001202	hp.json	saliva molecularis|saliva atomaris|salivary gland secretion|sailva normalis	http://purl.obolibrary.org/obo/UBERON_0001836		uberon_slim
UBERON:0001839	biolink:AnatomicalEntity	bony labyrinth	A system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted].	AAO:0011078|EV:0100362|UMLS:C0458699|CALOHA:TS-2080|BTO:0004685|MA:0000238|NCIT:C33227|EMAPA:36580|FMA:60179|VHOG:0001219|XAO:0000193	hp.json	osseous labyrinth|osseus labyrinth|labyrinthus osseus	http://purl.obolibrary.org/obo/UBERON_0001839		uberon_slim|pheno_slim
UBERON:0001838	biolink:AnatomicalEntity	sublingual duct	A duct of a sublingual gland.	FMA:59983|EMAPA:36564|MA:0002699|BTO:0004558	hp.json		http://purl.obolibrary.org/obo/UBERON_0001838		uberon_slim|pheno_slim
UBERON:0001833	biolink:AnatomicalEntity	lip	One of the two fleshy folds which surround the opening of the mouth.	UMLS:C0023759|galen:Lip|GAID:76|MESH:D008046|SCTID:181221003|Wikipedia:Lip|EMAPA:32839|OpenCyc:Mx4rvVi4U5wpEbGdrcN5Y29ycA|MA:0000343|BTO:0001647|ZFA:0007006|FMA:59816|TAO:0007006|NCIT:C12220|VHOG:0000677|CALOHA:TS-0558	hp.json	labia oris|lips|labia oris	http://purl.obolibrary.org/obo/UBERON_0001833		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001832	biolink:AnatomicalEntity	sublingual gland	The small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland.	MESH:D013361|EV:0100062|GAID:941|VHOG:0000363|MA:0001588|FMA:59791|EMAPA:18809|BTO:0001315|NCIT:C12234|CALOHA:TS-0987|UMLS:C0038553	hp.json	ductus sublingualis|submaxillary gland|sublingual salivary gland|glandula sublingualis|Rivinus gland|Rivinus' gland	http://purl.obolibrary.org/obo/UBERON_0001832		uberon_slim|pheno_slim
UBERON:0001835	biolink:AnatomicalEntity	lower lip	Lip that covers the lower portion of the mouth.[TAO].	EHDAA2:0001020|MA:0000921|Wikipedia:Lower_lip|UMLS:C0458583|TAO:0002060|OpenCyc:Mx4rv842UpwpEbGdrcN5Y29ycA|NCIT:C94572|EMAPA:17909|ZFA:0005225|FMA:59818|SCTID:245777007	hp.json	labium inferius oris|lower jaw lip|labium inferius oris|lower jaw lip	http://purl.obolibrary.org/obo/UBERON_0001835		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001834	biolink:AnatomicalEntity	upper lip	Lip that covers the upper portion of the mouth.[TAO].	OpenCyc:Mx4rvWPv7pwpEbGdrcN5Y29ycA|VHOG:0001750|ZFA:0005226|MA:0000919|FMA:59817|TAO:0001970|EMAPA:17925	hp.json	labium superius oris|upper jaw lip	http://purl.obolibrary.org/obo/UBERON_0001834		uberon_slim|vertebrate_core|pheno_slim
HP:0006009	biolink:PhenotypicFeature	Broad phalanx	Increased side-to-side width of one or more phalanges of the fingers or toes.	UMLS:C1855185	hp.json	Wide digital bones|Widened phalanges|Wide phalanges|Broad phalanges	http://purl.obolibrary.org/obo/HP_0006009		
HP:0008668	biolink:PhenotypicFeature	Gonadal dysgenesis, male	Unusual gonadal development in a person with a 46,XY male karyotype, leading to an unassigned sex differentiation.	UMLS:C0018054|MSH:D006061	hp.json	46,xy gonadal dysgenesis	http://purl.obolibrary.org/obo/HP_0008668		
HP:0006006	biolink:PhenotypicFeature	Hypotrophy of the small hand muscles		UMLS:C1843228	hp.json	Degeneration of small hand muscles	http://purl.obolibrary.org/obo/HP_0006006		
HP:0008669	biolink:PhenotypicFeature	Abnormal spermatogenesis	Incomplete maturation or aberrant formation of the male gametes.	UMLS:C0520933|SNOMEDCT_US:4529005|UMLS:C4020789	hp.json	Impaired spermatogenesis|Abnormal sperm development	http://purl.obolibrary.org/obo/HP_0008669		
HP:0006008	biolink:PhenotypicFeature	Unilateral brachydactyly		UMLS:C1868164|UMLS:C4280467	hp.json	Short digits on one side	http://purl.obolibrary.org/obo/HP_0006008		
UBERON:0001840	biolink:AnatomicalEntity	semicircular canal	One of three half-circular, interconnected tubes located inside each ear[WP].	VHOG:0001144|BTO:0003383|UMLS:C0036622|ZFA:0000431|XAO:0000198|CALOHA:TS-2164|MESH:D012665|TAO:0000431|EMAPA:32832|EV:0100365|FMA:60186|AAO:0011098|GAID:776|MA:0000249|NCIT:C33527	hp.json	ductus semicirculares|scc|semicircular ducts|semicircular canals|canalis semicircularis	http://purl.obolibrary.org/obo/UBERON_0001840		uberon_slim|vertebrate_core|pheno_slim
HP:0008664	biolink:PhenotypicFeature	Urethral sphincter sclerosis		UMLS:C4024643	hp.json		http://purl.obolibrary.org/obo/HP_0008664		
HP:0008663	biolink:PhenotypicFeature	Renal sarcoma	A sarcoma of the kidney.	SNOMEDCT_US:254918001|NCIT:C3158|UMLS:C0346251	hp.json		http://purl.obolibrary.org/obo/HP_0008663		
HP:0008666	biolink:PhenotypicFeature	Impaired histidine renal tubular absorption		UMLS:C4024642	hp.json		http://purl.obolibrary.org/obo/HP_0008666		
HP:0008665	biolink:PhenotypicFeature	Clitoral hypertrophy	Hypertrophy of the clitoris.	UMLS:C0156394|SNOMEDCT_US:80212005	hp.json	Prominent clitoris|Hypertrophic clitoris|Enlarged clitoris|Clitoromegaly|Clitoral enlargement	http://purl.obolibrary.org/obo/HP_0008665		
HP:0008660	biolink:PhenotypicFeature	Renotubular dysgenesis	A developmental defect characterized by absence or poor development of proximal renal tubules.	UMLS:C0266313|MSH:C537048|SNOMEDCT_US:702397002	hp.json	Renal tubular dysgenesis	http://purl.obolibrary.org/obo/HP_0008660		
HP:0006000	biolink:PhenotypicFeature	Ureteral obstruction	Obstruction of the flow of urine through the ureter.	Fyler:4492|UMLS:C0041956|MSH:D014517|SNOMEDCT_US:20018005	hp.json		http://purl.obolibrary.org/obo/HP_0006000		
HP:0008661	biolink:PhenotypicFeature	Urethral stenosis	Abnormal narrowing of the urethra.	SNOMEDCT_US:76618002|SNOMEDCT_US:236647003|MSH:D014525|UMLS:C0041974	hp.json	Narrowing of the urethra	http://purl.obolibrary.org/obo/HP_0008661		
GO:0048469	biolink:BiologicalProcess	cell maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a cell to attain its fully functional state.		hp.json	functional differentiation	http://purl.obolibrary.org/obo/GO_0048469		goslim_pir
GO:0048468	biolink:BiologicalProcess	cell development	The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.		hp.json	terminal differentiation	http://purl.obolibrary.org/obo/GO_0048468		goslim_candida
GO:0036477	biolink:CellularComponent	somatodendritic compartment	The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.		hp.json		http://purl.obolibrary.org/obo/GO_0036477		
GO:0061448	biolink:BiologicalProcess	connective tissue development	The progression of a connective tissue over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0061448		
GO:0048477	biolink:BiologicalProcess	oogenesis	The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.	Wikipedia:Oogenesis	hp.json	ovum development	http://purl.obolibrary.org/obo/GO_0048477		
GO:0097402	biolink:BiologicalProcess	neuroblast migration	The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.		hp.json		http://purl.obolibrary.org/obo/GO_0097402		
GO:0048486	biolink:BiologicalProcess	parasympathetic nervous system development	The process whose specific outcome is the progression of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.		hp.json		http://purl.obolibrary.org/obo/GO_0048486		
GO:0048485	biolink:BiologicalProcess	sympathetic nervous system development	The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter.		hp.json		http://purl.obolibrary.org/obo/GO_0048485		
GO:0048483	biolink:BiologicalProcess	autonomic nervous system development	The process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands.		hp.json		http://purl.obolibrary.org/obo/GO_0048483		
GO:0061462	biolink:BiologicalProcess	protein localization to lysosome	A process in which a protein is transported to, or maintained in, a location within a lysosome.		hp.json		http://purl.obolibrary.org/obo/GO_0061462		
GO:0061450	biolink:BiologicalProcess	trophoblast cell migration	Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst.		hp.json		http://purl.obolibrary.org/obo/GO_0061450		
GO:0061453	biolink:BiologicalProcess	interstitial cell of Cajal differentiation	The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction.		hp.json	ICC differentiation	http://purl.obolibrary.org/obo/GO_0061453		
GO:0061458	biolink:BiologicalProcess	reproductive system development	The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.		hp.json		http://purl.obolibrary.org/obo/GO_0061458		
PR:000011178	biolink:Protein	nuclear factor NF-kappa-B p100 subunit	A transcription factor NF-kappa-B subunit that is a translation product of the human NFKB2 gene or a 1:1 ortholog thereof.		hp.json	LYT10|nuclear factor of kappa light polypeptide gene enhancer in B-cells 2|lyt10|lymphocyte translocation chromosome 10 protein|H2TF1|oncogene Lyt-10|NFKB2|DNA-binding factor KBF2	http://purl.obolibrary.org/obo/PR_000011178		
UBERON:0001902	biolink:AnatomicalEntity	epithelium of small intestine	An epithelium that is part of a small intestine [Automatically generated definition].	ZFA:0005127|MA:0001553|FMA:62017|TAO:0005127|BTO:0001258|EMAPA:35778|CALOHA:TS-2104	hp.json	epithelial tissue of small intestine|mid intestine epithelium|small intestine epithelial tissue|epithelium of small bowel|small intestine epithelium|small intestinal epithelium|epithelial tissue of small bowel|small bowel epithelial tissue|small bowel epithelium	http://purl.obolibrary.org/obo/UBERON_0001902		vertebrate_core
UBERON:0001905	biolink:AnatomicalEntity	pineal body	A midline, cone like structure located in the dorso-caudal roof of the 3rd ventricle, attached by peduncles to the habenular and posterior commissures. The stalk contains nerve fibers, blood vessels, connective tissue and parenchymal cells (Paxinos, The Rat Central Nervous System, 2nd ed, pg 399).	UMLS:C0031939|MAT:0000448|OpenCyc:Mx4rv2FMGpwpEbGdrcN5Y29ycA|BAMS:Pi|GAID:453|VHOG:0000051|EFO:0000865|NLXANAT:1010009|BIRNLEX:1184|EHDAA2:0001466|MESH:D010870|MBA:953|MA:0000175|NCIT:C12398|EHDAA:7523|galen:PinealGland|DHBA:10460|EV:0100221|XAO:0000160|UMLS:C0031939|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=297|CALOHA:TS-0789|EV:0100131|FMA:62033|HBA:4532|BTO:0001067|ZFA:0000019|EMAPA:18778|BM:P|AAO:0010549|BAMS:PIN|TAO:0000019	hp.json	glandula pinealis|conarium|stirnorgan|pineal gland (Galen)|epiphysis cerebri|pineal|pineal gland|pineal organ|epiphysis|glandula pinealis|Pi|frontal organ|corpus pineale	http://purl.obolibrary.org/obo/UBERON_0001905		vertebrate_core|organ_slim|pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0001901	biolink:AnatomicalEntity	epithelium of trachea	The epithelial lining of the trachea which contains numerous ciliated cells.	MA:0001862|UMLS:C1179002|NCIT:C33797|EHDAA:5007|CALOHA:TS-1061|FMA:62015|EHDAA2:0002069|EMAPA:18409|BTO:0001389|EMAPA:16855|VHOG:0001045	hp.json	trachea epithelial tissue|epithelial tissue of windpipe|epithelium of windpipe|trachea epithelium|windpipe epithelium|epithelial tissue of trachea|windpipe epithelial tissue|tracheal epithelium	http://purl.obolibrary.org/obo/UBERON_0001901		pheno_slim|human_reference_atlas
GO:0061484	biolink:BiologicalProcess	hematopoietic stem cell homeostasis	Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.		hp.json		http://purl.obolibrary.org/obo/GO_0061484		
UBERON:0001908	biolink:AnatomicalEntity	optic tract	Diencephalic white matter (tract) which is comprised of retinal ganglion cell axons after which they have passed through the optic chiasm[ZFA]. Predominantly white matter structure found in diencephalon consisting of fibers originating in the retina. The optic tract is considered to extend from the point of the optic chiasm and terminates largely, although not exclusively, in the lateral geniculate complex. Other fibers end in the superior colliculus and other structures in the diencephalon, midbrain and brainstem (MM)[NIF].	DHBA:10589|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=460|NCIT:C33218|BIRNLEX:1684|BAMS:opt|VHOG:0001164|DMBA:17785|XAO:0004101|ZFA:0000252|EMAPA:35617|MA:0001099|TAO:0000252|MESH:D014795|BM:Tel-OT|MBA:125|HBA:9309|FMA:62046|UMLS:C0152405|GAID:735|UMLS:C0152405|EMAPA:16678	hp.json	tractus opticus|optic lemniscus|optic tracts|tractus optici|visual pathway	http://purl.obolibrary.org/obo/UBERON_0001908		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas
GO:0097435	biolink:BiologicalProcess	supramolecular fiber organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.		hp.json	fibril organization|extracellular fibril organisation|extracellular fibril organization and biogenesis|fibril organisation|extracellular fibril organization	http://purl.obolibrary.org/obo/GO_0097435		
HP:0008609	biolink:PhenotypicFeature	Morphological abnormality of the middle ear	An abnormality of the morphology or structure of the middle ear.	UMLS:C1857456	hp.json	Middle ear malformation|Morphological abnormality of the middle ear	http://purl.obolibrary.org/obo/HP_0008609		
HP:0008606	biolink:PhenotypicFeature	Supraauricular pit	Benign congenital lesion of the supraauricular soft tissue consisting of a blind-ending narrow tube or pit.	UMLS:C1862059	hp.json	Supraauricular sinus|Pit above the ear|Supraauricular sinuses|Supraauricular fistula	http://purl.obolibrary.org/obo/HP_0008606		
NCBITaxon:554915	biolink:OrganismalEntity	Amoebozoa		PMID:30257078|PMID:23020233|GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_554915		
HP:0008605	biolink:PhenotypicFeature	Unilateral external ear deformity		UMLS:C1834043	hp.json	Deformed external ear on one side	http://purl.obolibrary.org/obo/HP_0008605		
HP:0008608	biolink:PhenotypicFeature	Hypertrophic auricular cartilage		UMLS:C1857263	hp.json		http://purl.obolibrary.org/obo/HP_0008608		
HP:0008607	biolink:PhenotypicFeature	Progressive conductive hearing impairment	A progressive type of conductive deafness.	UMLS:C1861325	hp.json	Progressive conductive deafness	http://purl.obolibrary.org/obo/HP_0008607		
GO:0097447	biolink:CellularComponent	dendritic tree	The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.	NIF_Subcellular:sao172297168	hp.json		http://purl.obolibrary.org/obo/GO_0097447		
UBERON:5106049	biolink:AnatomicalEntity	digit 2 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of digit 2 plus the associated metapodial element.		hp.json	digit 2 skeleton|digit II digitopodial skeleton|digit 2	http://purl.obolibrary.org/obo/UBERON_5106049		
UBERON:5106048	biolink:AnatomicalEntity	digit 1 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of digit 1 plus the associated metapodial element.		hp.json	digit 1 skeleton|digit I digitopodial skeleton|digit 1	http://purl.obolibrary.org/obo/UBERON_5106048		
UBERON:5106050	biolink:AnatomicalEntity	digit 3 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of digit 3 plus the associated metapodial element.		hp.json	digit 3|digit III digitopodial skeleton|digit 3 skeleton	http://purl.obolibrary.org/obo/UBERON_5106050		
UBERON:5106052	biolink:AnatomicalEntity	digit 5 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of digit 5 plus the associated metapodial element.		hp.json	digit 5 skeleton|digit V digitopodial skeleton|digit 5	http://purl.obolibrary.org/obo/UBERON_5106052		
UBERON:5106051	biolink:AnatomicalEntity	digit 4 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of digit 4 plus the associated metapodial element.		hp.json	digit 4 skeleton|digit IV digitopodial skeleton|digit 4	http://purl.obolibrary.org/obo/UBERON_5106051		
GO:0097427	biolink:CellularComponent	microtubule bundle	An arrangement of closely apposed microtubules running parallel to each other.	NIF_Subcellular:sao1872343973	hp.json	microtubule fascicle	http://purl.obolibrary.org/obo/GO_0097427		
CHEBI:26822	biolink:ChemicalSubstance	sulfide	Any sulfur molecular entity that involves either covalently bonded or anionic sulfur.		hp.json	sulphides	http://purl.obolibrary.org/obo/CHEBI_26822		3_STAR
CHEBI:26820	biolink:ChemicalSubstance	sulfates	Salts and esters of sulfuric acid		hp.json	sulfuric acid derivative|sulphates|sulfates	http://purl.obolibrary.org/obo/CHEBI_26820		3_STAR
HP:0200136	biolink:PhenotypicFeature	Oral-pharyngeal dysphagia		UMLS:C0267071|SNOMEDCT_US:71457002|MSH:D003680	hp.json	Oral pharyngeal dysphagia|Oropharyngeal dysphagia	http://purl.obolibrary.org/obo/HP_0200136		
CHEBI:38808	biolink:ChemicalSubstance	calcium channel modulator	A membrane transport modulator that is able to regulate intracellular calcium levels.		hp.json	calcium channel modulators	http://purl.obolibrary.org/obo/CHEBI_38808		3_STAR
CHEBI:38807	biolink:ChemicalSubstance	calcium channel agonist	Agents that increase calcium influx into calcium channels of excitable tissues.		hp.json	calcium channel agonists|calcium channel activators|calcium channel activator	http://purl.obolibrary.org/obo/CHEBI_38807		3_STAR
HP:0200135	biolink:PhenotypicFeature	obsolete Macrocephaly due to hydrocephalus			hp.json		http://purl.obolibrary.org/obo/HP_0200135		
HP:0200134	biolink:PhenotypicFeature	Epileptic encephalopathy	A condition in which epileptiform abnormalities are believed to contribute to the progressive disturbance in cerebral function. Epileptic encephalaopathy is characterized by (1) electrographic EEG paroxysmal activity that is often aggressive, (2) seizures that are usually multiform and intractable, (3) cognitive, behavioral and neurological deficits that may be relentless, and (4) sometimes early death.	UMLS:C0543888	hp.json	Convulsive encephalopathy	http://purl.obolibrary.org/obo/HP_0200134		
HP:0200133	biolink:PhenotypicFeature	Lumbosacral meningocele		UMLS:C2675557	hp.json		http://purl.obolibrary.org/obo/HP_0200133		
HP:0200138	biolink:PhenotypicFeature	Bilateral choanal atresia/stenosis		UMLS:C4021884	hp.json		http://purl.obolibrary.org/obo/HP_0200138		
GO:2000068	biolink:BiologicalProcess	regulation of defense response to insect	Any process that modulates the frequency, rate or extent of defense response to insect.		hp.json	regulation of physiological defense response to insect	http://purl.obolibrary.org/obo/GO_2000068		
PR:000001786	biolink:Protein	prominin-1	A prominin that is a translation product of the human PROM1 gene or a 1:1 ortholog thereof.		hp.json	Prom|PROM1|CD133|MSTP061|prominin-like protein 1|antigen AC133|PROML1|antigen AC133 homolog	http://purl.obolibrary.org/obo/PR_000001786		
PR:000001785	biolink:Protein	prominin	A protein with core architecture consisting of one Prominin (Pfam:PF05478) domain. The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and human prominin and prominin-like 1 are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space followed by four, alternating small cytoplasmic and large extracellular, loops and a cytoplasmic C-terminal domain.	PIRSF:PIRSF017831|PANTHER:PTHR22730	hp.json		http://purl.obolibrary.org/obo/PR_000001785		
CHEBI:26833	biolink:ChemicalSubstance	sulfur atom		KEGG:D06527|CAS:7704-34-9|PPDB:605|KEGG:C00087|CAS:7704-34-9|WebElements:S	hp.json	sulfur|S|Elemental sulfur|sulfur|sulfur|theion|Schwefel|S|soufre|16S|sulphur|azufre	http://purl.obolibrary.org/obo/CHEBI_26833		3_STAR
CHEBI:26834	biolink:ChemicalSubstance	sulfur-containing amino acid			hp.json	sulfur-containing amino acids	http://purl.obolibrary.org/obo/CHEBI_26834		3_STAR
CHEBI:26835	biolink:ChemicalSubstance	sulfur molecular entity			hp.json	sulfur molecular entities|sulfur molecular entity	http://purl.obolibrary.org/obo/CHEBI_26835		3_STAR
CHEBI:26836	biolink:ChemicalSubstance	sulfuric acid	A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.	PMID:19397353|PMID:22047659|KEGG:C00059|PPDB:606|CAS:7664-93-9|PMID:22364556|CAS:7664-93-9|PMID:22435616|PMID:22296037|KEGG:D05963|KNApSAcK:C00007530|PMID:13568755|Reaxys:2037554|PMID:22136045|PMID:16122922|PMID:22204399|Wikipedia:Sulfuric_acid|PMID:22267186|MolBase:4|Gmelin:2122|CAS:7664-93-9	hp.json	Acide sulfurique|sulfuric acid|Acidum sulfuricum|hydrogen tetraoxosulfate(2-)|dihydroxidodioxidosulfur|dihydrogen tetraoxosulfate|tetraoxosulfuric acid|Sulfuric acid|[S(OH)2O2]|Schwefelsaeureloesungen|Acido sulfurico|hydrogen tetraoxosulfate(VI)|sulphuric acid|sulfuric acid|[SO2(OH)2]|H2SO4	http://purl.obolibrary.org/obo/CHEBI_26836		3_STAR
HP:0200143	biolink:PhenotypicFeature	Megaloblastic erythroid hyperplasia		UMLS:C1334688|UMLS:C1850020	hp.json	Bone marrow biopsy shows megaloblastic erythroid hyperplasia	http://purl.obolibrary.org/obo/HP_0200143		
HP:0200141	biolink:PhenotypicFeature	Small, conical teeth		UMLS:C4280284|UMLS:C1851883|UMLS:C4280285	hp.json	Small, pointed teeth|Conical microdontia|Small, peg shaped teeth|Small, cone shaped teeth	http://purl.obolibrary.org/obo/HP_0200141		
UBERON:0035295	biolink:AnatomicalEntity	left ear	The organ of hearing located on the left side of the head[ncit,modified].	FMA:53642|NCIT:C81259	hp.json		http://purl.obolibrary.org/obo/UBERON_0035295		
HP:0200147	biolink:PhenotypicFeature	Neuronal loss in basal ganglia	A reduction in the number of nerve cells in the basal ganglia.	UMLS:C2750913	hp.json		http://purl.obolibrary.org/obo/HP_0200147		
HP:0200146	biolink:PhenotypicFeature	Mucoid extracellular matrix accumulation	An increase of medial mucoid extracellular matrix creating translamellar and/or intralamellar expansions including extracellular pools as noted on an H&E stain and/or a stain to highlight extracellular matrix material (Movat's pentachrome, Alcian blue, etc.).	MSH:C536230|UMLS:C0392775|SNOMEDCT_US:42182000|SNOMEDCT_US:45894003|SNOMEDCT_US:234021009	hp.json	Cystic medial necrosis of the aorta|MEMA	http://purl.obolibrary.org/obo/HP_0200146		
HP:0200144	biolink:PhenotypicFeature	obsolete Anaphylactoid purpura			hp.json		http://purl.obolibrary.org/obo/HP_0200144		
HP:0200149	biolink:PhenotypicFeature	CSF lymphocytic pleiocytosis	An increased lymphocyte count in the cerebrospinal fluid.	UMLS:C0427877|SNOMEDCT_US:167719009	hp.json	CSF lymphocytosis	http://purl.obolibrary.org/obo/HP_0200149		
HP:0200148	biolink:PhenotypicFeature	Abnormal liver function tests during pregnancy		UMLS:C4021883|UMLS:C2750654	hp.json	Abnormal liver function tests during pregnancy|Abnormal liver function tests during pregnancy, resolves postpartum	http://purl.obolibrary.org/obo/HP_0200148		
GO:0120229	biolink:BiologicalProcess	protein localization to motile cilium	A process in which a protein is transported to, or maintained in, a location within a motile cilium.		hp.json	protein localization to nonmotile primary cilium	http://purl.obolibrary.org/obo/GO_0120229		
GO:0120222	biolink:BiologicalProcess	regulation of blastocyst development	Any process that modulates the frequency, rate or extent of blastocyst development.		hp.json		http://purl.obolibrary.org/obo/GO_0120222		
GO:0120223	biolink:BiologicalProcess	larynx morphogenesis	The process in which the larynx is generated and organized. The larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.		hp.json	laryngeal morphogenesis	http://purl.obolibrary.org/obo/GO_0120223		
GO:0120224	biolink:BiologicalProcess	larynx development	The biological process whose specific outcome is the progression of a larynx from an initial condition to its mature state. This process begins with the formation of the larynx and ends with the mature structure. A larynx is a continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration.		hp.json		http://purl.obolibrary.org/obo/GO_0120224		
HGNC:13633	biolink:Gene	ADIPOQ (human)	A protein coding gene ADIPOQ in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=13633		
UBERON:0011298	biolink:AnatomicalEntity	submucosa of uterine tube	The submucous layer of the wall of the uterine tube.	SCTID:245489008|BTO:0002116	hp.json	tela submucosa tubae uterinae|submucosa of fallopian tube|submucous layer of uterine tube|uterine submucosa	http://purl.obolibrary.org/obo/UBERON_0011298		
HP:0200114	biolink:PhenotypicFeature	Metabolic alkalosis	Metabolic alkalosis is defined as a disease state where the pH is elevated to greater than 7.45 secondary to some metabolic process.	UMLS:C0220983|SNOMEDCT_US:1388004	hp.json		http://purl.obolibrary.org/obo/HP_0200114		
HP:0200113	biolink:PhenotypicFeature	Aphalangy of hands and feet		UMLS:C4021887	hp.json	Aphalangy, hands and feet	http://purl.obolibrary.org/obo/HP_0200113		
HP:0200111	biolink:PhenotypicFeature	Absent stapes head		UMLS:C4021888	hp.json		http://purl.obolibrary.org/obo/HP_0200111		
HP:0200118	biolink:PhenotypicFeature	Malabsorption of Vitamin B12		UMLS:C1850013|UMLS:C0750292	hp.json	Vitamin B12 deficiency caused by intestinal malabsorption|Malabsorption of cyanocobalamin	http://purl.obolibrary.org/obo/HP_0200118		
HP:0200117	biolink:PhenotypicFeature	Recurrent upper and lower respiratory tract infections	Increased susceptibility to upper and lower respiratory tract infections, as manifested by recurrent episodes of upper and lower respiratory tract infections.	UMLS:C1842777	hp.json		http://purl.obolibrary.org/obo/HP_0200117		
HP:0200116	biolink:PhenotypicFeature	Distal ileal atresia		UMLS:C3279409	hp.json		http://purl.obolibrary.org/obo/HP_0200116		
UBERON:0011299	biolink:AnatomicalEntity	white matter of telencephalon	A partion of white matter that is part of a telencephalon. This can be further subdivided in some species, for example, into hemisphere white matter and the corpus callosum.	ZFA:0000597|TAO:0000597|BIRNLEX:1075|FMA:83930|HBA:9230|HBA:9219	hp.json	telencephalic white matter|predominantly white regional part of telencephalon|telencephalic tracts|telencephalic tract/commissure	http://purl.obolibrary.org/obo/UBERON_0011299		
HP:0200119	biolink:PhenotypicFeature	Acute hepatitis	Acute hepatic injury resulting from inflammation typically accompanied by increased serum alanine transaminase activity. Etiologies include viral hepatitis, drugs, toxins, and autoimmune disorders.	SNOMEDCT_US:37871000|UMLS:C0267797	hp.json	Acute liver inflammation	http://purl.obolibrary.org/obo/HP_0200119		
UBERON:0011282	biolink:AnatomicalEntity	nail of pedal digit 5	A nail that is part of a pedal digit 5.	FMA:54356|EMAPA:18743	hp.json	nail of fifth toe|nail of little toe|nail of pedal digit V|claw of digit 5 of hind-paw|little toe nail|nail plate of little toe	http://purl.obolibrary.org/obo/UBERON_0011282		pheno_slim
HP:0200120	biolink:PhenotypicFeature	Chronic active hepatitis	Chronic hepatitis associated with recurrent clinical exacerbations, extrahepatic manifestations, and progression to cirrhosis.	SNOMEDCT_US:197284004|MSH:D006521|UMLS:C0520463	hp.json	Hepatitis, chronic active	http://purl.obolibrary.org/obo/HP_0200120		
UBERON:0011281	biolink:AnatomicalEntity	nail of pedal digit 4	A nail that is part of a pedal digit 4.	FMA:54353|EMAPA:18742	hp.json	nail plate of fourth toe|claw of digit 4 of hind-paw|nail of fourth toe|fourth toe nail|nail of pedal digit IV	http://purl.obolibrary.org/obo/UBERON_0011281		
UBERON:0011280	biolink:AnatomicalEntity	nail of pedal digit 3	A nail that is part of a pedal digit 3.	EMAPA:18741|FMA:54350	hp.json	nail of pedal digit III|third toe nail|claw of digit 3 of hind-paw|nail of third toe|nail plate of third toe	http://purl.obolibrary.org/obo/UBERON_0011280		
HP:0200125	biolink:PhenotypicFeature	Mitochondrial respiratory chain defects		UMLS:C2751582	hp.json		http://purl.obolibrary.org/obo/HP_0200125		
HP:0200124	biolink:PhenotypicFeature	Chronic hepatitis due to cryptosporidium infection	Chronic hepatitis associated with infection by cryptosporidia, as demonstrated (for example) by immunohistochemistry of liver tissue.	UMLS:C3808820	hp.json	Hepatitis, chronic, due to cryptosporidium infection	http://purl.obolibrary.org/obo/HP_0200124		
HP:0200123	biolink:PhenotypicFeature	Chronic hepatitis	Hepatitis that lasts for more than six months.	UMLS:C0019189|SNOMEDCT_US:76783007|MSH:D006521	hp.json	Chronic liver inflammation	http://purl.obolibrary.org/obo/HP_0200123		
HP:0200122	biolink:PhenotypicFeature	Atypical or prolonged hepatitis		UMLS:C1848456	hp.json	Atypical or prolonged liver inflammation	http://purl.obolibrary.org/obo/HP_0200122		
HP:0200129	biolink:PhenotypicFeature	obsolete Calcific mitral stenosis			hp.json		http://purl.obolibrary.org/obo/HP_0200129		
HP:0200128	biolink:PhenotypicFeature	Biventricular hypertrophy	Thickening of the heart walls in both ventricles.	UMLS:C0281788	hp.json		http://purl.obolibrary.org/obo/HP_0200128		
UBERON:0011289	biolink:AnatomicalEntity	pharyngobasilar fascia	The pharyngeal aponeurosis (or pharyngobasilar fascia, or fibrous coat), is situated between the mucous and muscular layers. It is thick above where the muscular fibers are wanting, and is firmly connected to the basilar portion of the occipital and the petrous portions of the temporal bones. As it descends it diminishes in thickness, and is gradually lost. It is strengthened posteriorly by a strong fibrous band, which is attached above to the pharyngeal spine on the under surface of the basilar portion of the occipital bone, and passes downward, forming a median raphe, which gives attachment to the Constrictores pharyngis.	FMA:55074	hp.json	pharyngeal aponeurosis|pharyngeal aponeurosis	http://purl.obolibrary.org/obo/UBERON_0011289		
HP:0200127	biolink:PhenotypicFeature	Atrial cardiomyopathy	Any complex of structural, architectural, contractile or electrophysiological changes affecting the atria with the potential to produce clinically relevant manifestations.	UMLS:C4021885	hp.json		http://purl.obolibrary.org/obo/HP_0200127		
HP:0200126	biolink:PhenotypicFeature	obsolete Amyloid cardiomyopathy			hp.json		http://purl.obolibrary.org/obo/HP_0200126		
CHEBI:26819	biolink:ChemicalSubstance	sulfuric ester	An ester of an alcohol and sulfuric acid.		hp.json	sulfuric acid ester|sulfate ester|sulfuric acid esters	http://purl.obolibrary.org/obo/CHEBI_26819		3_STAR
GO:2000027	biolink:BiologicalProcess	regulation of animal organ morphogenesis	Any process that modulates the frequency, rate or extent of animal organ morphogenesis.		hp.json	regulation of histogenesis and organogenesis	http://purl.obolibrary.org/obo/GO_2000027		
CHEBI:167559	biolink:ChemicalSubstance	glycan	Any oligosaccharide, polysaccharide or their derivatives consisting of monosaccharides or monosaccharide derivatives linked by glycosidic bonds. See also http://www.ontobee.org/ontology/GNO?iri=http://purl.obolibrary.org/obo/GNO_00000001.		hp.json	glycans	http://purl.obolibrary.org/obo/CHEBI_167559		3_STAR
PR:000025797	biolink:Protein	integrin alpha lacking A domain	An integrin alpha that lacks an A domain. This type of integrin is often cleaved into heavy and light chains.	PIRSF:PIRSF005666	hp.json	fam:ITGAsansA	http://purl.obolibrary.org/obo/PR_000025797		
PR:000025796	biolink:Protein	integrin alpha	A protein that is composed of a long N-terminal extracellular domain, a transmembrane domain and a short cytoplasmic C-terminal domain. The N-terminal domain contains beta-propeller repeats (interrupted by an A domain in a subset of integrins alpha), while the C-terminal domain contains a GFFxR motif.		hp.json		http://purl.obolibrary.org/obo/PR_000025796		
GO:2000026	biolink:BiologicalProcess	regulation of multicellular organismal development	Any process that modulates the frequency, rate or extent of multicellular organismal development.		hp.json		http://purl.obolibrary.org/obo/GO_2000026		
HP:0200102	biolink:PhenotypicFeature	Sparse or absent eyelashes		UMLS:C1835157|UMLS:C1862855|UMLS:C3551431	hp.json	Sparse or absent eyelashes|Sparse to absent eyelashes|Partial to total absence of eyelashes	http://purl.obolibrary.org/obo/HP_0200102		
HP:0200101	biolink:PhenotypicFeature	Decreased/absent ankle reflexes		UMLS:C1850816	hp.json	Decreased/absent ankle reflexes|Decreased or absent ankle reflexes	http://purl.obolibrary.org/obo/HP_0200101		
HP:0200107	biolink:PhenotypicFeature	Shortened inner dynein arms		UMLS:C4021890	hp.json		http://purl.obolibrary.org/obo/HP_0200107		
HP:0200106	biolink:PhenotypicFeature	Absent/shortened dynein arms		UMLS:C4021891	hp.json		http://purl.obolibrary.org/obo/HP_0200106		
HP:0200105	biolink:PhenotypicFeature	Absent fifth toenail		UMLS:C4021892	hp.json	Absent fifth toenail|Missing fifth toenail	http://purl.obolibrary.org/obo/HP_0200105		
HP:0200104	biolink:PhenotypicFeature	Absent fifth fingernail	Absence of nail of little finger.	UMLS:C4020917	hp.json	Absent fifth fingernail|Absent nail of fifth finger	http://purl.obolibrary.org/obo/HP_0200104		
HP:0200109	biolink:PhenotypicFeature	Absent/shortened outer dynein arms		UMLS:C2750161	hp.json	Respiratory cilia have shortened or absent outer dynein arms	http://purl.obolibrary.org/obo/HP_0200109		
HP:0200108	biolink:PhenotypicFeature	Shortened outer dynein arms		UMLS:C4021889	hp.json		http://purl.obolibrary.org/obo/HP_0200108		
GO:2000035	biolink:BiologicalProcess	regulation of stem cell division	Any process that modulates the frequency, rate or extent of stem cell division.		hp.json	regulation of stem cell renewal	http://purl.obolibrary.org/obo/GO_2000035		
UBERON:0035267	biolink:AnatomicalEntity	neck of gallbladder	The narrowest portion of the gallbladder and distal to the cystic duct.	FMA:14538|NCIT:C32649	hp.json	gallbladder neck|cervix of gallbladder	http://purl.obolibrary.org/obo/UBERON_0035267		
GO:0036484	biolink:BiologicalProcess	trunk neural crest cell migration	The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo.		hp.json	trunk NCC migration	http://purl.obolibrary.org/obo/GO_0036484		
HP:0200095	biolink:PhenotypicFeature	obsolete Anterior open bite			hp.json		http://purl.obolibrary.org/obo/HP_0200095		
HP:0200094	biolink:PhenotypicFeature	Frontal open bite		UMLS:C1857012	hp.json		http://purl.obolibrary.org/obo/HP_0200094		
HP:0008361	biolink:PhenotypicFeature	Corticospinal tract pallor		UMLS:C4024690	hp.json		http://purl.obolibrary.org/obo/HP_0008361		
HP:0008360	biolink:PhenotypicFeature	Neonatal hypoproteinemia	A neonatal decreased concentration of proteins in the blood.	UMLS:C4024691	hp.json		http://purl.obolibrary.org/obo/HP_0008360		
HP:0200099	biolink:PhenotypicFeature	obsolete Peripheral retinal pigmentation abnormalities			hp.json		http://purl.obolibrary.org/obo/HP_0200099		
UBERON:0001546	biolink:AnatomicalEntity	posterior tibial vein	A vein of the lower limb carries blood from the posterior compartment and plantar surface of the foot to the popliteal vein which it forms when it joins with the anterior tibial vein. Like most deep veins, the posterior tibial vein is accompanied by an artery of the same name, the posterior tibial artery, along its course. [WP,unvetted].	FMA:44332|UMLS:C0226832|EMAPA:37183|MA:0002245|galen:PosteriorTibialVein|OpenCyc:Mx4rwA9GD5wpEbGdrcN5Y29ycA|NCIT:C33386	hp.json	venae tibiales posteriores	http://purl.obolibrary.org/obo/UBERON_0001546		human_reference_atlas|uberon_slim
HP:0200098	biolink:PhenotypicFeature	Absent skin pigmentation	Lack of skin pigmentation (coloring).	UMLS:C2673954	hp.json	Absent skin pigmentation|Lack of skin coloration	http://purl.obolibrary.org/obo/HP_0200098		
UBERON:0001549	biolink:AnatomicalEntity	dorsal metatarsal vein	The dorsal metatarsal veins are veins which drain the metatarsus of the foot. [WP,unvetted].	FMA:44377|EMAPA:37143|NCIT:C52689|MA:0002105|UMLS:C0835053	hp.json	metatarsal vein|venae metatarsales dorsales	http://purl.obolibrary.org/obo/UBERON_0001549		human_reference_atlas
HP:0200097	biolink:PhenotypicFeature	Oral mucosal blisters	Blisters arising in the mouth.	UMLS:C0853945	hp.json	Oral mucosal blisters|Blisters of mouth|Bullae of oral mucosa|Oral mucosa blisters|Blebs of oral mucosa|Oral blistering	http://purl.obolibrary.org/obo/HP_0200097		
HP:0200096	biolink:PhenotypicFeature	Triangular-shaped open mouth	A facial appearance characterized by a permanently or nearly permanently opened mouth, in which the upper lip is tented in a way that the opened mouth has the appearance of a triangle.	UMLS:C1859292	hp.json	Triangular-shaped open mouth	http://purl.obolibrary.org/obo/HP_0200096		
HP:0033323	biolink:PhenotypicFeature	Glomerular capillary wall duplication with cellular interposition	Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix with interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM.		hp.json		http://purl.obolibrary.org/obo/HP_0033323		
HP:0033322	biolink:PhenotypicFeature	Glomerular capillary wall duplication without cellular interposition	Double contouring of the original glomerular basement membrane (GBM)/additional layer(s) of overlying basement membrane matrix, with or without endocapillary hypercellularity and no evidence of interposed migrated cells (mesangial, endothelial, monocytes) between the layers of original GBM and de novo GBM.		hp.json		http://purl.obolibrary.org/obo/HP_0033322		
HP:0033325	biolink:PhenotypicFeature	Elevated circulating sebacic acid concentration	Increased concentration of sebacic acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033325		
HP:0033324	biolink:PhenotypicFeature	Elevated circulating homovanillic acid concentration	Increased concentration of homovanillic acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033324		
HP:0033321	biolink:PhenotypicFeature	Glomerular obsolescence	Globally sclerotic glomeruli are that are small and without hyalinosis and may appear with collapse of the tuft with collagenization of the urinary space. Bowman's capsule is completely or partially absent and there is no periglomerular fibrosis and glomerular size is decreased by more than 50% compared to all other glomeruli in the same biopsy. Obsolescent glomeruli may appear to be receding into the interstitium.		hp.json		http://purl.obolibrary.org/obo/HP_0033321		
HP:0033320	biolink:PhenotypicFeature	Mesangial cell loss	Loss of mesangial cells segmentally or globally.		hp.json		http://purl.obolibrary.org/obo/HP_0033320		
UBERON:0013525	biolink:AnatomicalEntity	stomach lumen	The anatomical space that is enclosed by a stomach.	FMA:14585|EMAPA:18395	hp.json	gastric cavity|cavity of stomach	http://purl.obolibrary.org/obo/UBERON_0013525		
HP:0033327	biolink:PhenotypicFeature	Nail psoriasis	Psoriatic nail abnormality characterized by the presence of neutrophils in the nail bed epithelium, hyperkeratosis with parakeratosis, presence of exudates on the corneal epithelium, focal hypogranulosis and psoriasiform hyperplasia of the nail bed.		hp.json		http://purl.obolibrary.org/obo/HP_0033327		
UBERON:8300002	biolink:AnatomicalEntity	left forelimb	A forelimb that is on the left side of a pectoral complex.	FMA:7186	hp.json		http://purl.obolibrary.org/obo/UBERON_8300002		
UBERON:0013526	biolink:AnatomicalEntity	otocyst lumen	An anatomical cavity that is part of a ear vesicle.	EHDAA2:0004121|EMAPA:25363	hp.json	lumen of otocyst	http://purl.obolibrary.org/obo/UBERON_0013526		
HP:0033326	biolink:PhenotypicFeature	Elevated circulating hydroxyphenlyllactic acid concentration	An increased concentration of 4-hydroxyphenlyllactic acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033326		
UBERON:8300001	biolink:AnatomicalEntity	right forelimb	A forelimb that is on the right side of a pectoral complex.	FMA:7185	hp.json		http://purl.obolibrary.org/obo/UBERON_8300001		
HP:0033329	biolink:PhenotypicFeature	Abnormal postural reflex	Anomaly of the physiological response to maintain the body's posture when movement and position is altered.		hp.json	Abnormal postural reaction	http://purl.obolibrary.org/obo/HP_0033329		
UBERON:8300004	biolink:AnatomicalEntity	left hindlimb	A hindlimb that is on the left side of a pelvic complex.	FMA:7188	hp.json		http://purl.obolibrary.org/obo/UBERON_8300004		
HP:0033328	biolink:PhenotypicFeature	Type II pneumocyte hyperplasia	Increase in the number of type II pneumocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0033328		
UBERON:8300003	biolink:AnatomicalEntity	right hindlimb	A hindlimb that is on the right side of a pelvic complex.	FMA:7187	hp.json		http://purl.obolibrary.org/obo/UBERON_8300003		
UBERON:0001554	biolink:AnatomicalEntity	skin of hip	A zone of skin that is part of a hip region.	EMAPA:18148|FMA:45282|MA:0000658	hp.json	zone of skin of hip region|zone of skin of regio coxae|hip region zone of skin|hip skin|regio coxae zone of skin|zone of skin of hip|hip zone of skin	http://purl.obolibrary.org/obo/UBERON_0001554		
HP:0008356	biolink:PhenotypicFeature	obsolete Combined hyperlipidemia			hp.json		http://purl.obolibrary.org/obo/HP_0008356		
PR:000001944	biolink:Protein	transcription factor PU.1	A protein that is a translation product of the human SPI1 gene or a 1:1 ortholog thereof.		hp.json	SPI1|Sfpi-1|SFFV proviral integration 1 protein|31 kDa-transforming protein|Sfpi1	http://purl.obolibrary.org/obo/PR_000001944		
HP:0008358	biolink:PhenotypicFeature	Hyperprolinemia	An increased concentration of proline in the blood.	UMLS:C0268528|SNOMEDCT_US:59655002	hp.json	Prolinemia	http://purl.obolibrary.org/obo/HP_0008358		
UBERON:0001556	biolink:AnatomicalEntity	lower urinary tract	Subdivision of urinary system which consists of the urinary bladder and the urethra.	MA:0002636|galen:LowerUrinaryTract|FMA:45659	hp.json		http://purl.obolibrary.org/obo/UBERON_0001556		uberon_slim|pheno_slim
UBERON:0001555	biolink:AnatomicalEntity	digestive tract	A tube extending from the mouth to the anus.	EHDAA2:0000726|OpenCyc:Mx4rvVi0GpwpEbGdrcN5Y29ycA|EMAPA:16247|NCIT:C34082|ZFA:0000112|FBbt:00003125|BILA:0000083|TGMA:0001819|UMLS:C0017189|VHOG:0000309|TAO:0000112|BTO:0000545|galen:AlimentaryTract|MA:0000917|FMA:45615|BTO:0000511|AAO:0010023|WBbt:0005743|EHDAA:518	hp.json	digestive tube|alimentary canal|enteric tract|gut|gut tube|digestive canal|alimentary tract	http://purl.obolibrary.org/obo/UBERON_0001555		uberon_slim|vertebrate_core
HP:0008357	biolink:PhenotypicFeature	Reduced factor XIII activity	Decreased activity of coagulation factor XIII (also known as fibrin stabilizing factor). Activated Factor XIII cross-links fibrin polymers solidifying the clot.	UMLS:C4024692	hp.json		http://purl.obolibrary.org/obo/HP_0008357		
UBERON:0025525	biolink:AnatomicalEntity	motor system	The part of the central nervous system that is involved with movement.	NLXANAT:090805	hp.json	motor system	http://purl.obolibrary.org/obo/UBERON_0025525		
HP:0008352	biolink:PhenotypicFeature	Impaired platelet adhesion	An abnormality of adhesion of thrombocytes. Normally, platelets adhere to collagen in the vascular subendothelium within seconds of injury via a receptor made up of glycoprotein Ia and IIa and GPVI and to vWF via receptor GPIb/IX/V. The adherent platelets then release granules that lead to platelet activation and aggregation.	UMLS:C4024694	hp.json	Impaired thrombocytes adhesion	http://purl.obolibrary.org/obo/HP_0008352		
PR:000001945	biolink:Protein	transferrin receptor protein 1	A protein that is a translation product of the human TFRC gene or a 1:1 ortholog thereof.		hp.json	T9|TFRC|TfR1|Trfr|TfR|p90|CD71|TR	http://purl.obolibrary.org/obo/PR_000001945		
UBERON:0001552	biolink:AnatomicalEntity	kidney arcuate artery	One of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries.	EMAPA:28215|FMA:70497|MA:0002583	hp.json	arcuate artery|renal arcuate artery	http://purl.obolibrary.org/obo/UBERON_0001552		uberon_slim|pheno_slim|human_reference_atlas
HP:0008354	biolink:PhenotypicFeature	Factor X activation deficiency	Reduced ability to transform factor X into its activated form factor Xa.	UMLS:C4024693	hp.json		http://purl.obolibrary.org/obo/HP_0008354		
UBERON:0001551	biolink:AnatomicalEntity	vein of hindlimb zeugopod		FMA:44561|MA:0002231|EMAPA:37231	hp.json	sural vein	http://purl.obolibrary.org/obo/UBERON_0001551		
HP:0008353	biolink:PhenotypicFeature	Neutral hyperaminoaciduria	The presence of an abnormally increased concentration of neutral amino acids in the urine. The neutral amino acids are tryptophan, alanine, asparagine, glutamine, histidine, isoleucine, leucine, phenylalanine, serine, threonine, tyrosine and valine.	UMLS:C1856194	hp.json		http://purl.obolibrary.org/obo/HP_0008353		
HP:0008372	biolink:PhenotypicFeature	Abnormality of vitamin A metabolism		UMLS:C4024686	hp.json		http://purl.obolibrary.org/obo/HP_0008372		
HP:0008371	biolink:PhenotypicFeature	Abnormal metatarsal ossification	Any abnormal process of ossification of the metatarsal bones, which normally are each ossified from two centers: one for the body, and one for the head (metatarsal II,III,IV, and V) and one for the body and one for the base (metatarsal I). The ossification process begins in the center of the body about the ninth week, and extends toward either extremity. The center for the base of the first metatarsal appears about the third year, and the centers for the heads of the other bones between the fifth and eighth years. They join the bodies between the eighteenth and twentieth years.	UMLS:C4021543	hp.json	Abnormal ossification involving metatarsal bones|Abnormal maturation of long bone of foot	http://purl.obolibrary.org/obo/HP_0008371		
UBERON:0001536	biolink:AnatomicalEntity	left common carotid artery plus branches	The leftmost of the two common carotid arteries, originating from the aortic arch in the thorax.	OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvg7rcJwpEbGdrcN5Y29ycA|OpenCyc:Mx4rdz4xcLVIEduAAAAOpmP6tw|Wikipedia:Left_common_carotid_artery|NCIT:C32956|FMA:4058|UMLS:C0226087|SCTID:362043008|EMAPA:35491|MA:0001927	hp.json	trunk of left common carotid tree|left common carotid artery|left common carotid artery	http://purl.obolibrary.org/obo/UBERON_0001536		human_reference_atlas|uberon_slim
UBERON:0001535	biolink:AnatomicalEntity	vertebral artery	The first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck.	NCIT:C12819|ZFA:0005033|TAO:0005033|OpenCyc:Mx4rvg_ir5wpEbGdrcN5Y29ycA|EMAPA:17314|EHDAA2:0002192|VHOG:0000263|EHDAA:5328|MESH:D014711|MA:0002077|UMLS:C0042559|GAID:518|FMA:3956	hp.json	arteria vertebralis|vertebral arteries	http://purl.obolibrary.org/obo/UBERON_0001535		human_reference_atlas|uberon_slim|vertebrate_core|pheno_slim
HP:0033334	biolink:PhenotypicFeature	Abnormal embryonic development	An anomaly in the development of the embryo, that is, of the early developmental stage of development that follows the fertilization of an egg by sperm.		hp.json		http://purl.obolibrary.org/obo/HP_0033334		
HP:0033333	biolink:PhenotypicFeature	Jaw contracture	Limitation of motion of the jaw due to structural changes in a muscle such as the massseter responsible for jaw movement.		hp.json		http://purl.obolibrary.org/obo/HP_0033333		
UBERON:0013522	biolink:AnatomicalEntity	subdivision of tube			hp.json		http://purl.obolibrary.org/obo/UBERON_0013522		
UBERON:8300000	biolink:AnatomicalEntity	skin of scalp	A zone of skin that is part of a scalp.	FMA:24757	hp.json	zone of skin of adult scalp|adult scalp zone of skin|scalp zone of skin|zone of skin of scalp|scalp skin	http://purl.obolibrary.org/obo/UBERON_8300000		
HP:0033336	biolink:PhenotypicFeature	Zygotic cleavage failure	Failure of a fertilized oocyte to undergo the first round of cell division.		hp.json	Failure of zygotic cell division	http://purl.obolibrary.org/obo/HP_0033336		
HP:0033335	biolink:PhenotypicFeature	Abnormal preimplantation embryonic development	An anomaly in the development of the embryo in a stage prior to implantation.		hp.json		http://purl.obolibrary.org/obo/HP_0033335		
HP:0033330	biolink:PhenotypicFeature	Impaired neck-righting reflex	Abnormal neck-righting response, which is said to be a physiological response when a child is placed flat on his or her back and the head is turned 90 degrees to the right or the left. With a normal neck-righting response, there follows a reflected torsion of the vertebral column in the same direction as the induced rotation of the neck. That is, the whole body follows the direction in which the head was turned. The response is present from birth to the age of five years.		hp.json		http://purl.obolibrary.org/obo/HP_0033330		
HP:0033332	biolink:PhenotypicFeature	Elevated circulating amyloid A	An increased concentration of serum amyloid A in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033332		
HP:0033331	biolink:PhenotypicFeature	Acute phase response	Presence of one or more manifestations of the acute phase response. Acute phase proteins (APP) are blood proteins primarily synthesized by hepatocytes as part of the acute phase response (APR). The APR is part of the early-defense or innate immune system, which is triggered by different stimuli including trauma, infection, stress, neoplasia, and inflammation. The APR results in a complex systemic reaction with the goal of reestablishing homeostasis and promoting healing.		hp.json		http://purl.obolibrary.org/obo/HP_0033331		
HP:0033338	biolink:PhenotypicFeature	Abnormal female meiosis	Anomalous oocyte meiosis		hp.json		http://purl.obolibrary.org/obo/HP_0033338		
UBERON:0013514	biolink:AnatomicalEntity	space surrounding organism	The space that surrounds an organism.		hp.json	external to organism|outside of body	http://purl.obolibrary.org/obo/UBERON_0013514		
UBERON:0013515	biolink:AnatomicalEntity	subdivision of oviduct	A section through the tube or network of tubes that connects the ovaries to the outside of the body.	FMA:18302	hp.json	zone of uterine tube|subdivision of fallopian tube|subdivision of uterine tube|subdivision of oviduct|uterine tube zone	http://purl.obolibrary.org/obo/UBERON_0013515		non_informative
HP:0033337	biolink:PhenotypicFeature	Abnormal gametogenesis	An anomaly in the process by a a haploid cell is formed from a diploid cells through meiosis. In males, diploid spermatogonia produce two haploid cells (secondary spermatocytes) in meiosis I and four haploid spermatids in meiosis II. In females, primordial germ cells under meiosis II before birth to form primary oocytes. Once puberty cell begins, these cells form secondary oocytes through meiosis II.		hp.json		http://purl.obolibrary.org/obo/HP_0033337		
HP:0033339	biolink:PhenotypicFeature	Increased circulating inosine concentration	An increased concentration of inosine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033339		
UBERON:0001543	biolink:AnatomicalEntity	popliteal lymph node	The lymph nodes which drain the legs; contained in the popliteal fossa.	UMLS:C0588057|NCIT:C53146|FMA:44227|MA:0000738	hp.json	popliteal lymph node|popliteal lymph glands|popliteal glands	http://purl.obolibrary.org/obo/UBERON_0001543		uberon_slim|pheno_slim
HP:0008366	biolink:PhenotypicFeature	Foot joint contracture	Contractures of one or more joints of the feet meaning chronic loss of joint motion due to structural changes in non-bony tissue.	SNOMEDCT_US:239742004|UMLS:C0343149	hp.json	Joint contractures involving the joints of the feet|Contractures of the foot joints|Contractures involving the joints of the feet	http://purl.obolibrary.org/obo/HP_0008366		
HP:0008369	biolink:PhenotypicFeature	Abnormal tarsal ossification	An abnormality of the formation and mineralization of any of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.	UMLS:C4021544|UMLS:C4025075	hp.json	Abnormal maturation of ankle bones|Abnormal ossification of tarsal bones|Hardening of ankle bones	http://purl.obolibrary.org/obo/HP_0008369		
HP:0008368	biolink:PhenotypicFeature	Tarsal synostosis	Synostosis (bony fusion) involving one or more bones of the tarsus (calcaneus, talus, cuboid, navicular, cuneiiform bones).	UMLS:C0265654|SNOMEDCT_US:27173008|MSH:D000070604	hp.json	Fused ankle bones|Tarsal fusion|Tarsal bone synostosis|Tarsal bone fusion|Tarsal fusions|Synostosis involving tarsal bones|Synostosis of tarsal bones	http://purl.obolibrary.org/obo/HP_0008368		
UBERON:0001544	biolink:AnatomicalEntity	popliteal vein	The popliteal vein course runs alongside the popliteal artery but carries the blood from the knee joint and muscles in the thigh and calf back to the heart. Its origin is defined by the junction of the posterior tibial vein and anterior tibial vein. It drains the peroneal vein before reaching the knee joint and turns into the femoral vein when leaving the adductor canal (also known as Hunter's canal). The popliteal artery extends from the femoral artery behind the popliteal fossa which is the space behind the knee. [WP,unvetted].	GAID:537|NCIT:C33339|UMLS:C0032652|galen:PoplitealVein|EMAPA:37181|FMA:44327|MA:0002197|OpenCyc:Mx4rv8Ch-JwpEbGdrcN5Y29ycA|MESH:D011152	hp.json	vena poplitea	http://purl.obolibrary.org/obo/UBERON_0001544		uberon_slim|human_reference_atlas
PR:000001954	biolink:Protein	tumor necrosis factor receptor superfamily member 11A	A protein that is a translation product of the human TNFRSF11A gene or a 1:1 ortholog thereof.	IUPHARobj:1881|PIRSF:PIRSF038806	hp.json	receptor activator of NF-KB|RANK|osteoclast differentiation factor receptor|ODFR|CD265|TNFRSF11A	http://purl.obolibrary.org/obo/PR_000001954		
HP:0008363	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the tarsal bones	Absence or underdevelopment of the tarsal bones.	UMLS:C1848671	hp.json	Absent/underdeveloped ankle bone|Aplastic/hypoplastic tarsals|Absent/small ankle bone	http://purl.obolibrary.org/obo/HP_0008363		
HP:0008362	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the hallux	Absence or underdevelopment of the big toe.	UMLS:C1836213	hp.json	Absent/underdeveloped big toe|Aplastic/hypoplastic halluces|Absent/small big toe	http://purl.obolibrary.org/obo/HP_0008362		
HP:0008365	biolink:PhenotypicFeature	Abnormal talus morphology	An abnormality of the talus.	UMLS:C4024688	hp.json	Abnormal large bone of ankle	http://purl.obolibrary.org/obo/HP_0008365		
HP:0008364	biolink:PhenotypicFeature	Abnormality of the calcaneus	An abnormality of the calcaneus, also known as the heel bone, one of the or heel bone, one of the components of the tarsus of the foot which make up the heel.	UMLS:C4024689	hp.json	Abnormal heel bone	http://purl.obolibrary.org/obo/HP_0008364		
UBERON:0025533	biolink:AnatomicalEntity	proprioceptive system	The sensory system for the sense of proprioception.	NLXANAT:090814	hp.json	proprioceptive system	http://purl.obolibrary.org/obo/UBERON_0025533		
UBERON:0001529	biolink:AnatomicalEntity	brachiocephalic artery	The short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery.	SCTID:244244002|galen:BrachioCephalicArtery|FMA:3932|EMAPA:17615|MESH:D016122|NCIT:C32814|MA:0001922|EFO:0002550|OpenCyc:Mx4rv9mMTpwpEbGdrcN5Y29ycA|EHDAA2:0000835|Wikipedia:Brachiocephalic_artery|UMLS:C0006094|GAID:476	hp.json	truncus brachiocephalicus|truncus brachiocephalicus|innominate artery|truncus brachiocephalicus|innominate artery|innominate|brachiocephalic trunk|innominate	http://purl.obolibrary.org/obo/UBERON_0001529		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
HP:0200073	biolink:PhenotypicFeature	Respiratory insufficiency due to defective ciliary clearance		UMLS:C3552099	hp.json		http://purl.obolibrary.org/obo/HP_0200073		
UBERON:0001528	biolink:AnatomicalEntity	radio-ulnar joint	A joint that connects the radius and the ulna. Examples: proximal and distal radio-ulnar joints.	MA:0003145|OpenCyc:Mx4rvlO2nJwpEbGdrcN5Y29ycA|FMA:38863|EMAPA:19206	hp.json	articulation of the radus and ulna|radioulnar joint|radioulnar articulation	http://purl.obolibrary.org/obo/UBERON_0001528		pheno_slim|uberon_slim
HP:0200072	biolink:PhenotypicFeature	Episodic quadriplegia	Intermittent episodes of paralysis of all four limbs.	UMLS:C1863062	hp.json	Quadriplegia, episodic	http://purl.obolibrary.org/obo/HP_0200072		
HP:0011990	biolink:PhenotypicFeature	Abnormality of neutrophil physiology	A functional abnormality of neutrophils.	UMLS:C4023093	hp.json		http://purl.obolibrary.org/obo/HP_0011990		
HP:0011991	biolink:PhenotypicFeature	Abnormal neutrophil count	A deviation from the normal range of neutrophil cell counts in the circulation.	UMLS:C4023092	hp.json	Abnormal neutrophil cell number	http://purl.obolibrary.org/obo/HP_0011991		
HP:0200071	biolink:PhenotypicFeature	Peripheral vitreoretinal degeneration	A type of vitreoretinal degeneration with manifestations that are concentrated at the periphery of the retina.	UMLS:C3280349	hp.json		http://purl.obolibrary.org/obo/HP_0200071		
HP:0011992	biolink:PhenotypicFeature	Abnormality of neutrophil morphology	An abnormal form or size of neutrophils.	UMLS:C4023091	hp.json		http://purl.obolibrary.org/obo/HP_0011992		
HP:0200070	biolink:PhenotypicFeature	Peripheral retinal atrophy		UMLS:C3553016	hp.json	Wasting of the outer part of the retina	http://purl.obolibrary.org/obo/HP_0200070		
HP:0011993	biolink:PhenotypicFeature	Impaired neutrophil bactericidal activity	A reduction in the ability of neutrophils to kill bacteria.	UMLS:C4023090	hp.json		http://purl.obolibrary.org/obo/HP_0011993		
HP:0011994	biolink:PhenotypicFeature	Abnormal atrial septum morphology	An abnormality of the interatrial septum.	UMLS:C0344722|Fyler:2002|SNOMEDCT_US:253363004	hp.json	Abnormality of the atrial septum|Abnormal interatrial septum morphology	http://purl.obolibrary.org/obo/HP_0011994		
CHEBI:26764	biolink:ChemicalSubstance	steroid hormone	Any steroid that acts as hormone.		hp.json	hormona esteroide|Steroidhormon|hormones steroides|Steroidhormone|hormone steroide|hormonas esteroideas|steroid hormones	http://purl.obolibrary.org/obo/CHEBI_26764		3_STAR
HP:0011995	biolink:PhenotypicFeature	Atrial septal dilatation	A bulging of the interatrial septum towards one side. In adults, atrial septal aneurysm can be defined as a protrusion of the aneurysm of >10 mm beyond the plane of the atrial septum as measured by transesophageal echocardiography.	UMLS:C0521533|SNOMEDCT_US:95440004	hp.json	Atrial septal aneurysm	http://purl.obolibrary.org/obo/HP_0011995		
CHEBI:51721	biolink:ChemicalSubstance	alpha,beta-unsaturated ketone	A ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) or R(1)C#C-C(=O)R(2) (R(2) =/= H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position.		hp.json	alpha,beta-unsaturated ketones	http://purl.obolibrary.org/obo/CHEBI_51721		3_STAR
HP:0011996	biolink:PhenotypicFeature	Elevated coagulation factor V activity	Increased activity of coagulation factor V, Factor V, which is activated to factor Va by means of minute amounts of thrombin (and inactivated by larger amounts of thrombin). Activated factor V (fVa) is a cofactor in the formation of the prothrombinase complex.	UMLS:C4021106	hp.json	Plasma factor V elevated|Elevated factor V activity	http://purl.obolibrary.org/obo/HP_0011996		
UBERON:0013510	biolink:AnatomicalEntity	lumbar vertebra pre-cartilage condensation	A lumbar vertebra endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0013510		
HP:0033345	biolink:PhenotypicFeature	Neuralgia	Pain (An unpleasant sensory and emotional experience) along the course of a nerve.		hp.json		http://purl.obolibrary.org/obo/HP_0033345		
HP:0033344	biolink:PhenotypicFeature	Pleural cobblestoning	A pleural cobblestone appearance characterized by irregular bumps surrounded by depressed lines in open lung biopsy. Caused by underlying scarring causing retraction of the interlobular septa where they insert on the pleura.		hp.json		http://purl.obolibrary.org/obo/HP_0033344		
HP:0033347	biolink:PhenotypicFeature	Cognitive epileptic aura	A purely subjective manifestation of an epileptic seizure pertaining to altered cognition.		hp.json		http://purl.obolibrary.org/obo/HP_0033347		
HP:0033346	biolink:PhenotypicFeature	Psychic epileptic aura	Aura with affective, mnemonic or composite perceptual phenomena including illusory or composite hallucinatory events.		hp.json	Psychic aura	http://purl.obolibrary.org/obo/HP_0033346		
HP:0033341	biolink:PhenotypicFeature	Elevated circulating sitosterol concentration	An increased concentration of beta-sitosterol in the blood circulation.		hp.json	Elevated circulating beta-sitosterol concentration	http://purl.obolibrary.org/obo/HP_0033341		
HP:0033340	biolink:PhenotypicFeature	Increased circulating guanosine concentration	Increased concentration of guanosine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033340		
HP:0033343	biolink:PhenotypicFeature	Mucoid diarrhea	Passage of an increased number of stools containing mucus, a thick fluid substance secreted by mucous membranes.		hp.json	Mucous diarrhea|Mucous diarrhoea	http://purl.obolibrary.org/obo/HP_0033343		
HP:0033342	biolink:PhenotypicFeature	Anti-aquaporin 4 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against aquaporin-4.		hp.json	Anti-AQP4 antibody positivity	http://purl.obolibrary.org/obo/HP_0033342		
UBERON:0013507	biolink:AnatomicalEntity	thoracic vertebra cartilage element	A thoracic vertebra endochondral element that is composed primarily of cartilage tissue.	EHDAA2:0002014	hp.json	thoracic vertebral cartilage condensation group	http://purl.obolibrary.org/obo/UBERON_0013507		
UBERON:0013508	biolink:AnatomicalEntity	thoracic vertebra pre-cartilage condensation	A thoracic vertebra endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0013508		
UBERON:0013509	biolink:AnatomicalEntity	lumbar vertebra cartilage element	A lumbar vertebra endochondral element that is composed primarily of cartilage tissue.	EHDAA2:0001038	hp.json	lumbar vertebral cartilage condensation group	http://purl.obolibrary.org/obo/UBERON_0013509		
UBERON:0013503	biolink:AnatomicalEntity	caudal vertebra cartilage element	A caudal vertebra endochondral element that is composed primarily of cartilage tissue.	EHDAA2:0000260|EMAPA:18044	hp.json	coccygeal vertebral cartilage condensation group|coccygeal vertebra cartilage element|tail vertebral cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0013503		
HP:0008338	biolink:PhenotypicFeature	Partial functional complement factor D deficiency	A partial reduction in level of the complement component Factor D in circulation.	UMLS:C4024699	hp.json	Partial functional adipsin deficiency|Partial functional factor d deficiency	http://purl.obolibrary.org/obo/HP_0008338		
HP:0033349	biolink:PhenotypicFeature	Seizure cluster	A fourfold or greater increase of usual seizure frequency within a 3-day period, where the patient demonstrates full recovery between seizure events within the cluster. The seizure cluster should be recognisable by the primary clinician, carer or patient.		hp.json	Cyclical seizures|Serial seizures|Recurrent seizures|Crescendo seizures|Seizure flurries|Acute repetitive seizures	http://purl.obolibrary.org/obo/HP_0033349		
HP:0033348	biolink:PhenotypicFeature	Epileptic aura	An epileptic aura is a purely subjective clinical manifestation of an epileptic seizure. If an epileptic aura is not followed by loss of awareness or propagation to a bilateral tonic-clonic seizure then it is a type of focal aware non-motor seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0033348		
UBERON:0013504	biolink:AnatomicalEntity	caudal vertebra pre-cartilage condensation	A caudal vertebra endochondral element that is composed primarily of a pre-cartilage condensation.	EMAPA:18045	hp.json	coccygeal vertebra pre-cartilage condensation|tail vertebral pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0013504		
UBERON:0013505	biolink:AnatomicalEntity	cervical vertebra cartilage element	A cervical vertebra endochondral element that is composed primarily of cartilage tissue.	EHDAA2:0000240	hp.json	cervical vertebral cartilage condensation group	http://purl.obolibrary.org/obo/UBERON_0013505		
HP:0008339	biolink:PhenotypicFeature	Diaminoaciduria	An increased urine level of any amino acid carrying two amino groups (Asparagine, glutamine and lysine, cystine, ornithine).	UMLS:C4024698	hp.json		http://purl.obolibrary.org/obo/HP_0008339		
UBERON:0013506	biolink:AnatomicalEntity	cervical vertebra pre-cartilage condensation	A cervical vertebra endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0013506		
UBERON:0001532	biolink:AnatomicalEntity	internal carotid artery	A terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes[MP].	EMAPA:16328|AAO:0011054|SCTID:362045001|OpenCyc:Mx4rvYx8KZwpEbGdrcN5Y29ycA|VHOG:0000267|NCIT:C32836|EHDAA:408|Wikipedia:Internal_carotid_artery|BTO:0004697|UMLS:C0007276|AAO:0010219|MA:0001930|ZFA:0005081|XAO:0000366|TAO:0005081|EHDAA2:0000873|EFO:0001952|FMA:3947|GAID:481|EHDAA:6389|MESH:D002343	hp.json	arteria carotis interna|internal carotid|ICA|cranial carotid artery|arteria carotis interna	http://purl.obolibrary.org/obo/UBERON_0001532		human_reference_atlas|efo_slim|uberon_slim|vertebrate_core|pheno_slim
HP:0011997	biolink:PhenotypicFeature	Postprandial hyperlactemia	Abnormally increased level of blood lactate following a meal.	UMLS:C4023089	hp.json		http://purl.obolibrary.org/obo/HP_0011997		
HP:0011998	biolink:PhenotypicFeature	Postprandial hyperglycemia	An increased concentration of glucose in the blood following a meal.	MSH:D006943|UMLS:C1855520	hp.json		http://purl.obolibrary.org/obo/HP_0011998		
UBERON:0001531	biolink:AnatomicalEntity	right common carotid artery plus branches	The rightmost of the two common carotid arteries, originating from in the neck from the brachiocephalic trunk.	FMA:3941|Wikipedia:Right_common_carotid_artery|UMLS:C0226086|OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvg7rcJwpEbGdrcN5Y29ycA|EMAPA:35749|OpenCyc:Mx4rtW9-AqgEEdudWQACs5b6Bw|SCTID:362042003|MA:0001928|NCIT:C33473	hp.json	right common carotid artery|right common carotid artery|trunk of right common carotid tree	http://purl.obolibrary.org/obo/UBERON_0001531		uberon_slim|human_reference_atlas
UBERON:0001534	biolink:AnatomicalEntity	right subclavian artery	The subclavian artery that supplies the right pectoral appendage.	FMA:3953|NCIT:C33490|EMAPA:37384|OpenCyc:Mx4rtW7hwqgEEdudWQACs5b6Bw|MA:0002047|EHDAA2:0004514|OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvp8u1JwpEbGdrcN5Y29ycA|UMLS:C0226261	hp.json	arteria subclavia dextra	http://purl.obolibrary.org/obo/UBERON_0001534		human_reference_atlas|uberon_slim|pheno_slim
HP:0008336	biolink:PhenotypicFeature	Complex organic aciduria		UMLS:C3151953	hp.json		http://purl.obolibrary.org/obo/HP_0008336		
HP:0011999	biolink:PhenotypicFeature	Paranoia	A persecutory delusion of supposed hostility of others.	UMLS:C1456784|SNOMEDCT_US:191667009|MSH:D010259	hp.json	Paranoia	http://purl.obolibrary.org/obo/HP_0011999		
UBERON:0001533	biolink:AnatomicalEntity	subclavian artery	One of two laterally paired arteries that supplies the pectoral appendages, usually branching from the dorsal aorta.	ZFA:0005086|FMA:3951|OpenCyc:Mx4rvp8u1JwpEbGdrcN5Y29ycA|TAO:0005086|GAID:511|EHDAA2:0001933|XAO:0000365|NCIT:C33643|MESH:D013348|EHDAA:4357|UMLS:C0038530|MA:0002045|AAO:0010232|EMAPA:17617	hp.json	pectoral artery|arterial tree of upper limb|subclavian arterial tree|PA|arteria subclavia|arteria subclavia	http://purl.obolibrary.org/obo/UBERON_0001533		human_reference_atlas|uberon_slim|vertebrate_core|unverified_taxonomic_grouping|pheno_slim
HP:0008335	biolink:PhenotypicFeature	obsolete Renal aminoaciduria		UMLS:C0002534|MSH:D000608	hp.json		http://purl.obolibrary.org/obo/HP_0008335		
HP:0008330	biolink:PhenotypicFeature	Reduced von Willebrand factor activity	Decreased activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces.	UMLS:C4024701	hp.json	Decreased von willebrand factor activity	http://purl.obolibrary.org/obo/HP_0008330		
UBERON:0001530	biolink:AnatomicalEntity	common carotid artery plus branches	A bilaterally paired branched artery that originates from the aortic arches and divides into and includes as parts the internal and external carotid arteries[cjm].	UMLS:C0162859|CALOHA:TS-0116|EHDAA:7331|EMAPA:17855|GAID:479|EHDAA2:0000217|VHOG:0000272|SCTID:362041005|FMA:3939|MESH:D017536|NCIT:C32352|MA:0001926|Wikipedia:Common_carotid_artery	hp.json	carotid artery|carotid artery system|a. carotis communis|common carotid artery|trunk of common carotid tree|a. carotis communis	http://purl.obolibrary.org/obo/UBERON_0001530		uberon_slim|pheno_slim|human_reference_atlas
HP:0008331	biolink:PhenotypicFeature	Elevated creatine kinase after exercise		UMLS:C4024700	hp.json	Elevated CK after exercise|Elevated phospho-CK after exercise|Increased creatine phosphokinase after exercise|Elevated creatine phosphokinase after exercise|Increased phospho-CK after exercise|Increased CK after exercise|Elevated CPK after exercise|Increased phospho-creatine kinase after exercise|Increased creatine kinase after exercise|Elevated phospho-creatine kinase after exercise	http://purl.obolibrary.org/obo/HP_0008331		
HP:0200084	biolink:PhenotypicFeature	Giant cell hepatitis	Chronic hepatitis characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver.	UMLS:C4020697|SNOMEDCT_US:69800000|UMLS:C2675624|UMLS:C2673820|UMLS:C0027613	hp.json	Giant cell hepatitis shown on biopsy|Giant cell hepatitis on biopsy|Giant cell hepatitis on liver biopsy	http://purl.obolibrary.org/obo/HP_0200084		
UBERON:0001518	biolink:AnatomicalEntity	skin of wrist	A zone of skin that is part of a wrist [Automatically generated definition].	UMLS:C0222223|MA:0000638|FMA:38280|EMAPA:37351|NCIT:C52752	hp.json	carpal region zone of skin|zone of skin of wrist|wrist zone of skin|zone of skin of carpal region|wrist skin	http://purl.obolibrary.org/obo/UBERON_0001518		
HP:0200083	biolink:PhenotypicFeature	Severe limb shortening		UMLS:C1835446	hp.json	Severe limb shortening	http://purl.obolibrary.org/obo/HP_0200083		
UBERON:0001517	biolink:AnatomicalEntity	skin of elbow	A zone of skin that is part of a elbow [Automatically generated definition].	FMA:38250|EMAPA:18051|NCIT:C52755|MA:0000610|UMLS:C0222213	hp.json	elbow skin|zone of skin of cubital region|zone of skin of elbow|cubital region zone of skin|elbow zone of skin	http://purl.obolibrary.org/obo/UBERON_0001517		
HP:0011980	biolink:PhenotypicFeature	Cholesterol gallstones	Gallstones composed primarily of cholesterol, usually about 2-3 cm in length with an oval form and a yellow or green/brown color.	UMLS:C0856727	hp.json		http://purl.obolibrary.org/obo/HP_0011980		
HP:0033350	biolink:PhenotypicFeature	Elevated forced expiratory volume in one second	An increase in the amount of air a person can forcefully expel in one second, compared to some standard or previous measure of same subject.		hp.json	Elevated FEV1	http://purl.obolibrary.org/obo/HP_0033350		
UBERON:0001519	biolink:AnatomicalEntity	skin of manus	A zone of skin that is part of a manus [Automatically generated definition].	EMAPA:18486|FMA:38295|UMLS:C0222224|NCIT:C52753|MA:0000630	hp.json	manus skin|skin of fore-paw|hand skin|skin of hand	http://purl.obolibrary.org/obo/UBERON_0001519		pheno_slim
HP:0011981	biolink:PhenotypicFeature	Pigment gallstones	Gallstones composed primarily of bilirubin and calcium salts (calcium bilirubinate) with a low cholesterol concentration.	UMLS:C3278865	hp.json		http://purl.obolibrary.org/obo/HP_0011981		
HP:0011982	biolink:PhenotypicFeature	Black pigment gallstones	A type of pigment gallstone that is hard and black, containing calcium carbonate and calcium phosphates.	UMLS:C4023098	hp.json		http://purl.obolibrary.org/obo/HP_0011982		
UBERON:0001514	biolink:AnatomicalEntity	descending aorta	The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries[GO]. The descending aorta is part of the aorta, the largest artery in the body. The descending aorta is the part of the aorta beginning at the aortic arch that runs down through the chest and abdomen. The descending aorta is divided into two portions, the thoracic and abdominal, in correspondence with the two great cavities of the trunk in which it is situated. Within the abdomen, the descending aorta branches into the two common iliac arteries which serve the legs. [WP,unvetted].	MA:0002571|EMAPA:18606|OpenCyc:Mx4rv4EE35wpEbGdrcN5Y29ycA|SCTID:261399002|FMA:3784|UMLS:C0011666|Wikipedia:Descending_aorta|NCIT:C32455	hp.json	pars descendens aortae|aorta descendens|pars descendens aortae|aorta descendens|aorta descendens|pars descendens aortae|aorta descendens	http://purl.obolibrary.org/obo/UBERON_0001514		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0001513	biolink:AnatomicalEntity	skin of pes	A zone of skin that is part of a pes [Automatically generated definition].	FMA:37834|EMAPA:18504|UMLS:C0222289|MA:0000654|NCIT:C52750	hp.json	skin of hind-paw|skin of foot|foot skin	http://purl.obolibrary.org/obo/UBERON_0001513		pheno_slim
HP:0011983	biolink:PhenotypicFeature	Brown pigment gallstones	A type of pigment gallstone that is brown, containing calcium fatty acids. These stones are softer than black pigment gallstones.	UMLS:C4023097	hp.json		http://purl.obolibrary.org/obo/HP_0011983		
HP:0011984	biolink:PhenotypicFeature	Atretic gallbladder	Failure of formation of the lumen of the gallbladder, often associated with gallbladder hypoplasia.	UMLS:C3277945	hp.json	Gallbladder atresia	http://purl.obolibrary.org/obo/HP_0011984		
UBERON:0001516	biolink:AnatomicalEntity	abdominal aorta	Abdominal part of aorta: the distal part of the descending aorta, which is the continuation of the thoracic part and gives rise to the inferior phrenic, lumbar, median sacral, superior and inferior mesenteric, middle suprarenal, renal, and testicular or ovarian arteries, and celiac trunk[BTO]. The abdominal aorta is the largest artery in the abdominal cavity. As part of the aorta, it is a direct continuation of descending aorta(of the thorax). [WP,unvetted].	BTO:0002976|EFO:0002524|GAID:470|MESH:D001012|UMLS:C0003484|FMA:3789|EMAPA:17856|Wikipedia:Abdominal_aorta|galen:AbdominalAorta|SCTID:244231007|NCIT:C32038|MA:0000474|OpenCyc:Mx4rvYhWCZwpEbGdrcN5Y29ycA	hp.json	pars abdominalis aortae|pars abdominalis aortae|abdominal part of aorta|descending abdominal aorta|aorta abdominalis|pars abdominalis aortae|abdominal part of aorta|pars abdominalis aortae|aorta abdominalis|aorta abdominalis	http://purl.obolibrary.org/obo/UBERON_0001516		pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0001515	biolink:AnatomicalEntity	thoracic aorta	The part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.	EFO:0002525|UMLS:C1522460|GAID:471|MESH:D001013|Wikipedia:Thoracic_aorta|BTO:0000157|OpenCyc:Mx4rveb9TpwpEbGdrcN5Y29ycA|EMAPA:18603|FMA:3786|MA:0002569|SCTID:302510009|galen:ThoracicAorta|NCIT:C33766	hp.json	thoracic part of aorta|pars thoracica aortae|aorta thoracica|pars thoracica aortae|aorta thoracalis|aorta thoracalis	http://purl.obolibrary.org/obo/UBERON_0001515		pheno_slim|efo_slim|uberon_slim
HP:0011985	biolink:PhenotypicFeature	Acholic stools	Clay colored stools lacking bile pigment.	SNOMEDCT_US:70396004|UMLS:C2675627	hp.json	Clay coloured stools|Clay colored stools|Acholia|Discolored, acholic stools	http://purl.obolibrary.org/obo/HP_0011985		
HP:0200085	biolink:PhenotypicFeature	Limb tremor		MSH:D014202|UMLS:C0235081	hp.json	Involuntary shaking of limb|Limb tremor|Tremor of limbs	http://purl.obolibrary.org/obo/HP_0200085		
HP:0033356	biolink:PhenotypicFeature	Elevated circulating o-phosphoserine concentration	An abnormally increased level of o-phosphoserine in the blood circulation. o-phosphoserine is a derivative of serine.		hp.json		http://purl.obolibrary.org/obo/HP_0033356		
HP:0033355	biolink:PhenotypicFeature	Increased urine deoxypyridinoline level	An increased level of deoxypyridinoline in the urine. Deoxypyridinoline is a crosslink product of collagen molecules found in bone and excreted in urine during bone degradation, has been described as a marker of bone turnover.		hp.json	Elevated urinary DPD	http://purl.obolibrary.org/obo/HP_0033355		
HP:0033358	biolink:PhenotypicFeature	Abnormal urine osmolality	A deviation from the normal range of concentration of particles in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033358		
UBERON:0013501	biolink:AnatomicalEntity	cloacal sphincter	A sphincter muscle that is part of a cloaca.	NCIT:C34129|UMLS:C1516658	hp.json	sphincter cloacae	http://purl.obolibrary.org/obo/UBERON_0013501		
UBERON:0013502	biolink:AnatomicalEntity	5th arch mesenchyme	A mesenchyme that is part of a pharyngeal arch 5.		hp.json	5th branchial arch mesenchyme|5th pharyngeal arch mesenchyme|pharyngeal arch 5 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0013502		
HP:0033357	biolink:PhenotypicFeature	Limited head rotation	Reduced range of motion turning the head side to side.		hp.json		http://purl.obolibrary.org/obo/HP_0033357		
HP:0033352	biolink:PhenotypicFeature	Pulmonary hypertensive crisis	Pulmonary hypertensive crisis involves sudden and potentially lethal increases in PAP and PVR that cause acute rise in right atrial and right ventricular end-diastolic pressure accompanied by low cardiac output.		hp.json	Pulmonary arterial hypertension crisis	http://purl.obolibrary.org/obo/HP_0033352		
HP:0033351	biolink:PhenotypicFeature	Candida esophagitis	Candida infections of the esophagus are considered opportunistic infections and are seen most commonly in immunosuppressed patients, the most common symptoms being dysphagia, odynophagia, and retrosternal pain.		hp.json	Esophageal candidiasis	http://purl.obolibrary.org/obo/HP_0033351		
HP:0033354	biolink:PhenotypicFeature	Abnormal urine metabolite level	Any deviation from the normal amount of a metabolite in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033354		
HP:0033353	biolink:PhenotypicFeature	Abnormal blood vessel morphology	Any structural anomaly of a blood vessel (artery, arteriole, capillary, venule, or vein).		hp.json		http://purl.obolibrary.org/obo/HP_0033353		
CL:1001433	biolink:Cell	epithelial cell of exocrine pancreas	An epithelial cell of the exocrine pancreas.	FMA:70986	hp.json	exocrine pancreas cell	http://purl.obolibrary.org/obo/CL_1001433		
HP:0033359	biolink:PhenotypicFeature	Hyperosthenuria	An abnormally high urinary specific gravity, i.e., increased concentration of solutes in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033359		
HP:0008348	biolink:PhenotypicFeature	Decreased circulating IgG2 level	A reduction in immunoglobulin levels of the IgG2 subclass in the blood circulation.	UMLS:C4021545	hp.json	Reduced IgG2 levels|Immunoglobulin IgG2 deficiency|Decreased IgG2 level in blood	http://purl.obolibrary.org/obo/HP_0008348		
HP:0008345	biolink:PhenotypicFeature	Hypoplasia of the iris dilator muscle	Underdevelopment of the dilatator pupillae.	UMLS:C4024696	hp.json	Underdeveloped iris dilator muscle|Hypoplasia of the pupil dilator muscle|Underdeveloped pupil dilator muscle	http://purl.obolibrary.org/obo/HP_0008345		
HP:0011986	biolink:PhenotypicFeature	Ectopic ossification	Formation of abnormal, extraskeletal bony tissue, i.e., the presence of bone in soft tissue where bone normally does not exist.	MSH:D009999|SNOMEDCT_US:128491006|MEDDRA:10065453|UMLS:C0029396	hp.json	Heterotopic ossification|Ectopic bone formation	http://purl.obolibrary.org/obo/HP_0011986		
HP:0008344	biolink:PhenotypicFeature	Elevated plasma branched chain amino acids	An increased concentration of a branched chain amino acid in the blood.	UMLS:C4024697	hp.json		http://purl.obolibrary.org/obo/HP_0008344		
HP:0011987	biolink:PhenotypicFeature	Ectopic ossification in muscle tissue	Formation of abnormal bony tissue within muscle tissue.	UMLS:C4023096	hp.json	Calcification of muscle tissue	http://purl.obolibrary.org/obo/HP_0011987		
HP:0008347	biolink:PhenotypicFeature	Decreased activity of mitochondrial complex IV	A reduction in the activity of the mitochondrial respiratory chain complex IV, which is part of the electron transport chain in mitochondria.	UMLS:C4020800	hp.json	Respiratory complex IV deficiency	http://purl.obolibrary.org/obo/HP_0008347		
HP:0011988	biolink:PhenotypicFeature	Ectopic ossification in tendon tissue	Formation of abnormal bony tissue within tendon tissue.	UMLS:C4023095	hp.json		http://purl.obolibrary.org/obo/HP_0011988		
HP:0008346	biolink:PhenotypicFeature	Increased red cell sickling tendency		UMLS:C4024695	hp.json	Increased sickling of erythrocytes|Increased sickling of red cells	http://purl.obolibrary.org/obo/HP_0008346		
HP:0011989	biolink:PhenotypicFeature	Ectopic ossification in ligament tissue	Formation of abnormal bony tissue within ligament tissue.	UMLS:C4023094	hp.json		http://purl.obolibrary.org/obo/HP_0011989		
HP:0008341	biolink:PhenotypicFeature	Distal renal tubular acidosis	A type of renal tubular acidosis characterized by a failure of acid secretion by the alpha intercalated cells of the cortical collecting duct of the distal nephron. The urine cannot be acidified below a pH of 5.3, associated with acidemia and hypokalemia.	SNOMEDCT_US:236461000|SNOMEDCT_US:86210009|MSH:D000141|UMLS:C1704380	hp.json	Renal tubular acidosis, type I	http://purl.obolibrary.org/obo/HP_0008341		
PR:000001937	biolink:Protein	tartrate-resistant acid phosphatase type 5	A protein that is a translation product of the human ACP5 gene or a 1:1 ortholog thereof.	PIRSF:PIRSF000898	hp.json	type 5 acid phosphatase|ACP5|tartrate-resistant acid ATPase|T5ap|Trap|TrATPase|TR-AP	http://purl.obolibrary.org/obo/PR_000001937		
NCBITaxon:131567	biolink:OrganismalEntity	cellular organisms		GC_ID:1	hp.json	biota	http://purl.obolibrary.org/obo/NCBITaxon_131567		
HP:0200050	biolink:PhenotypicFeature	Bracket metacarpal epiphyses		UMLS:C4021897	hp.json	Bracket shaped end part of long bone of hand	http://purl.obolibrary.org/obo/HP_0200050		
HP:0200055	biolink:PhenotypicFeature	Small hand	Disproportionately small hand.	SNOMEDCT_US:299032009|UMLS:C0575802	hp.json	Disproportionately small hands|Small hands|Small hand	http://purl.obolibrary.org/obo/HP_0200055		
HP:0200054	biolink:PhenotypicFeature	Foot monodactyly		UMLS:C4021896	hp.json		http://purl.obolibrary.org/obo/HP_0200054		
HP:0200053	biolink:PhenotypicFeature	Hemihypotrophy of lower limb	Shortening of a leg affecting only one side.	UMLS:C1844734	hp.json	Asymmetric leg shortening|Asymmetric lower limb shortness	http://purl.obolibrary.org/obo/HP_0200053		
HP:0200059	biolink:PhenotypicFeature	Metastatic angiosarcoma		UMLS:C0854892	hp.json		http://purl.obolibrary.org/obo/HP_0200059		
HP:0200058	biolink:PhenotypicFeature	Angiosarcoma		SNOMEDCT_US:33176006|SNOMEDCT_US:403977003|UMLS:C0018923|SNOMEDCT_US:39000009|MSH:D006394	hp.json		http://purl.obolibrary.org/obo/HP_0200058		
PR:P17433	biolink:Protein	transcription factor PU.1 (mouse)	A transcription factor PU.1 that is encoded in the genome of mouse.	UniProtKB:P17433	hp.json	Sfpi-1|SFFV proviral integration 1 protein (mouse)|31 kDa-transforming protein (mouse)|mSPI1|Spi1|Sfpi1	http://purl.obolibrary.org/obo/PR_P17433		
HP:0200057	biolink:PhenotypicFeature	Marcus Gunn pupil	An aberrant pupillary response characterized by (i) Constriction of pupils of both eyes when the light stimulus is applied to the normal eye, and (ii) Dilatation of pupils of both eyes when the light stimulus is rapidly transferred from the normal eye (after brief light exposure to the normal eye) to the affected eye.	UMLS:C0549122|SNOMEDCT_US:232122003|SNOMEDCT_US:247015002	hp.json	Relative afferent pupillary defect|Relative afferent pupil defect	http://purl.obolibrary.org/obo/HP_0200057		
HP:0200056	biolink:PhenotypicFeature	Macular scar	Scar tissue in the macula.	SNOMEDCT_US:18410006|UMLS:C0423428	hp.json	Macular scarring	http://purl.obolibrary.org/obo/HP_0200056		
CHEBI:61115	biolink:ChemicalSubstance	EC 3.5.1.98 (histone deacetylase) inhibitor	An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).	Wikipedia:Histone_deacetylase_inhibitor	hp.json	histone amidohydrolase inhibitor|histone amidohydrolase inhibitors|HDI|EC 3.5.1.98 inhibitor|histone deacetylase inhibitor|HDAC inhibitors|histone deacetylase (EC 3.5.1.98) inhibitor|HDACi|HDACis|HDAC inhibitor|histone deacetylase (EC 3.5.1.98) inhibitors|EC 3.5.1.98 (histone deacetylase) inhibitors|EC 3.5.1.98 inhibitors|histone deacetylase inhibitors|HDIs	http://purl.obolibrary.org/obo/CHEBI_61115		3_STAR
UBERON:0001592	biolink:AnatomicalEntity	bronchial vein	The bronchial veins are small vessels that return blood from the larger bronchi and structures at the roots of the lungs. The right side drains into the azygos vein, while the left side drains into the left superior intercostal vein or the accessory hemiazygos vein. The bronchial veins are counterparts to the bronchial arteries. The veins, however, do not return all of the blood supplied by the arteries; much of the blood that is carried in the bronchial arteries is returned to the heart via the pulmonary veins. [WP,unvetted].	FMA:4749|MA:0002088|NCIT:C53031|UMLS:C0226650|EMAPA:36284	hp.json	bronchial venous tree	http://purl.obolibrary.org/obo/UBERON_0001592		human_reference_atlas|uberon_slim
UBERON:0001591	biolink:AnatomicalEntity	thymic vein	A vein that drains blood from the thymus.	NCIT:C53143|FMA:4747|EMAPA:36325|MA:0002246|UMLS:C0226698	hp.json	thymic tributary of brachiocephalic vein|vena thymica|venae thymicae	http://purl.obolibrary.org/obo/UBERON_0001591		human_reference_atlas
UBERON:0001598	biolink:AnatomicalEntity	temporalis muscle	Pharyngeal arch 1 muscle that is innervated by the deep temporal branches of the trigeminal nerve and attaches to the wall of the braincase (including the cranial vault) and mandible.	UMLS:C0039487|EHDAA:10565|EHDAA2:0002001|EMAPA:25138|MA:0002390|FMA:49006|GAID:148|VHOG:0000929|MESH:D013703|NCIT:C33743	hp.json	temporalis|musculus temporalis|musculus temporalis|temporal muscle|jaw adductor muscle	http://purl.obolibrary.org/obo/UBERON_0001598		pheno_slim|uberon_slim
UBERON:0001597	biolink:AnatomicalEntity	masseter muscle	Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by masseteric nerve branches of the trigeminal nerve (CN V), and attaches to mandible and zygomatic arch.	MA:0002343|BTO:0001755|MESH:D008406|EFO:0001424|VHOG:0000823|EHDAA:10561|EHDAA2:0001067|NCIT:C13074|FMA:48996|UMLS:C0024876|EMAPA:25135|MFMO:0000075	hp.json	musculus masseter|masseter	http://purl.obolibrary.org/obo/UBERON_0001597		feed_aligned|pheno_slim|efo_slim|uberon_slim
HP:0008399	biolink:PhenotypicFeature	Circumungual hyperkeratosis	A thickening of the stratum corneum, the outer layer of the skin, in the region surrounding the nails.	UMLS:C4024681	hp.json	Thick skin around nails	http://purl.obolibrary.org/obo/HP_0008399		
UBERON:0001599	biolink:AnatomicalEntity	stapedius muscle	The muscle that stabilizes the stapes bone. The stapedius emerges from a pinpoint foramen in the apex of the pyramidal eminence (a hollow, cone-shaped prominence in the posterior wall of the tympanic cavity), and inserts into the neck of the stapes. [WP,unvetted].	EMAPA:18586|VHOG:0000813|GAID:164|MA:0001220|EHDAA:9029|MESH:D013198|UMLS:C0038151|FMA:49027|NCIT:C33611	hp.json	musculus stapedius|stapedius	http://purl.obolibrary.org/obo/UBERON_0001599		pheno_slim|uberon_slim
HP:0008396	biolink:PhenotypicFeature	Chronic monilial nail infection	Chronic infection of the nails by Candida species.	UMLS:C4024683	hp.json		http://purl.obolibrary.org/obo/HP_0008396		
UBERON:0001593	biolink:AnatomicalEntity	venous plexus	A congregation of multiple veins.	EMAPA:36327|FMA:4767|MA:0000069	hp.json	rete venosum|plexus venosus|venous network	http://purl.obolibrary.org/obo/UBERON_0001593		uberon_slim
HP:0008398	biolink:PhenotypicFeature	Hypoplastic fifth fingernail	A nail of the fifth finger that is diminished in length and width, i.e., underdeveloped nail of little finger.	UMLS:C4024682	hp.json	Underdeveloped fifth fingernail|Underdeveloped fingernail of pinkie finger|Underdeveloped fingernail of little finger|Underdeveloped fingernail of pinky finger	http://purl.obolibrary.org/obo/HP_0008398		
CHEBI:75767	biolink:ChemicalSubstance	animal metabolite	Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.		hp.json	animal metabolites	http://purl.obolibrary.org/obo/CHEBI_75767		3_STAR
CHEBI:75768	biolink:ChemicalSubstance	mammalian metabolite	Any animal metabolite produced during a metabolic reaction in mammals.		hp.json	mammalian metabolites	http://purl.obolibrary.org/obo/CHEBI_75768		3_STAR
HP:0200066	biolink:PhenotypicFeature	Ribbonlike corneal degeneration		UMLS:C4021894	hp.json		http://purl.obolibrary.org/obo/HP_0200066		
HP:0200065	biolink:PhenotypicFeature	Chorioretinal degeneration		UMLS:C0521683|SNOMEDCT_US:247177004	hp.json		http://purl.obolibrary.org/obo/HP_0200065		
HP:0200064	biolink:PhenotypicFeature	Asymmetry of iris pigmentation	Asymmetry between the two irides or asymmetry between different parts of one iris.	SNOMEDCT_US:247033008|MSH:C538115|UMLS:C0423318	hp.json		http://purl.obolibrary.org/obo/HP_0200064		
CHEBI:75769	biolink:ChemicalSubstance	B vitamin	Any member of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises of vitamin B1, B2, B3, B5, B6, B7, B9, and B12 (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such).	PMID:22743781|Wikipedia:B_vitamin|PMID:23093174|PMID:23462586|MetaCyc:B-vitamins|PMID:23690582|PMID:23449527|PMID:23238962	hp.json	vitamin B|B vitamins|B-group vitamins|B-group vitamin	http://purl.obolibrary.org/obo/CHEBI_75769		3_STAR
HP:0200063	biolink:PhenotypicFeature	Colorectal polyposis	Multiple abnormal growths that arise from the lining of the large intestine (colon or rectum) and protrude into the intestinal lumen.	SNOMEDCT_US:399505005|UMLS:C0949059	hp.json	Colorectal polyps	http://purl.obolibrary.org/obo/HP_0200063		
HP:0200068	biolink:PhenotypicFeature	Nonprogressive visual loss		UMLS:C4021893|UMLS:C3553696	hp.json	Decreased visual acuity, nonprogressive	http://purl.obolibrary.org/obo/HP_0200068		
HP:0200067	biolink:PhenotypicFeature	Recurrent spontaneous abortion	Repeated episodes of abortion (Expulsion of the product of fertilization before completing the term of gestation) without deliberate interference.	UMLS:C3279439	hp.json	Spontaneous abortion, recurrent	http://purl.obolibrary.org/obo/HP_0200067		
CHEBI:61120	biolink:ChemicalSubstance	nucleobase-containing molecular entity	Any compound that has a nucleobase as a part.		hp.json	nucleobase-containing molecular entities|nucleobase-containing compound|nucleobase-containing compounds	http://purl.obolibrary.org/obo/CHEBI_61120		3_STAR
UBERON:0001581	biolink:AnatomicalEntity	depressor labii inferioris	A muscle of facial expression, innervated by the facial nerve, attached to the skin of the lower lip, orbicularis oris muscle, and mandible, and superficial and lateral to the mentalis muscle. See Diogo et al., 2009; Burrows et al., 2011).	FMA:46816|MA:0002287|NCIT:C53152|UMLS:C0224119|MFMO:0000123|EMAPA:37516	hp.json		http://purl.obolibrary.org/obo/UBERON_0001581		uberon_slim
UBERON:0001580	biolink:AnatomicalEntity	levator labii superioris	The levator labii superioris (or quadratus labii superioris) is a broad sheet, the origin of which extends from the side of the nose to the zygomatic bone. Its medial fibers form the angular head, which arises by a pointed extremity from the upper part of the frontal process of the maxilla and passing obliquely downward and lateralward divides into two slips. One of these is inserted into the greater alar cartilage and skin of the nose; the other is prolonged into the lateral part of the upper lip, blending with the infraorbital head and with the Orbicularis oris. The intermediate portion or infraorbital head arises from the lower margin of the orbit immediately above the infraorbital foramen, some of its fibers being attached to the maxilla, others to the zygomatic bone. Its fibers converge, to be inserted into the muscular substance of the upper lip between the angular head and the Caninus. The lateral fibers, forming the zygomatic head, arise from the malar surface of the zygomatic bone immediately behind the zygomaticomaxillary suture and pass downward and medialward to the upper lip. [WP,unvetted].	EMAPA:37503|NCIT:C53164|UMLS:C1704248|MFMO:0000136|MA:0002333|FMA:46805	hp.json	musculus levator labii superioris	http://purl.obolibrary.org/obo/UBERON_0001580		uberon_slim
UBERON:0001587	biolink:AnatomicalEntity	subclavian vein	The subclavian vein is a paired large vein, one on either side of the body. Their diameter is approximately that of the smallest finger.	OpenCyc:Mx4rvvvtMZwpEbGdrcN5Y29ycA|galen:SubclavianVein|AAO:0010510|EHDAA:4455|MA:0002221|NCIT:C12794|FMA:4725|MESH:D013350|GAID:546|UMLS:C0038532|EHDAA2:0001934|EMAPA:17621	hp.json	vena subclavia|subclavian venous tree	http://purl.obolibrary.org/obo/UBERON_0001587		human_reference_atlas|uberon_slim
UBERON:0001586	biolink:AnatomicalEntity	internal jugular vein	One of two jugular veins that collect the blood from the brain, the superficial parts of the face, and the neck. [WP,unvetted].	galen:InternalJugularVein|AAO:0010236|MA:0002157|XAO:0000382|OpenCyc:Mx4rvqdb95wpEbGdrcN5Y29ycA|SCTID:181372005|RETIRED_EHDAA2:0000878|UMLS:C0226550|FMA:4724|NCIT:C32849|EHDAA:5407|EHDAA2:0000877|Wikipedia:Internal_jugular_vein|EMAPA:17620	hp.json	vena jugularis interna|vena jugularis interna|internal jugular|internal jugular venous tree	http://purl.obolibrary.org/obo/UBERON_0001586		human_reference_atlas|uberon_slim
CHEBI:75763	biolink:ChemicalSubstance	eukaryotic metabolite	Any  metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms.		hp.json	eukaryotic metabolites	http://purl.obolibrary.org/obo/CHEBI_75763		3_STAR
UBERON:0001582	biolink:AnatomicalEntity	buccinator muscle	The buccinator is a muscle that is attached to the mandible, skin, pterygomandibular raphe and maxilla, and is innervated by Cranial Nerve VII and participates in oropharyngeal behavior.	FMA:46834|MA:0002272|NCIT:C53150|EMAPA:37453|MFMO:0000002|UMLS:C0224121	hp.json	musculus buccinator|trumpeters muscle|buccinatorius|musculus buccinator|buccinator	http://purl.obolibrary.org/obo/UBERON_0001582		uberon_slim
UBERON:0001585	biolink:AnatomicalEntity	anterior vena cava	A vein that carries deoxygenated blood from the upper half of the body into the right atrium of the heart.	VHOG:0001195|EHDAA:8726|Wikipedia:Superior_vena_cava|galen:SuperiorVenaCava|EHDAA2:0001962|MA:0000481|UMLS:C0042459|GAID:549|MESH:D014683|NCIT:C12816|EMAPA:18417|BTO:0002683|FMA:4720|SCTID:181368006	hp.json	vena cava superior|vena maxima|superior vena cava|vena cava superior|precava|superior caval vein|vena maxima|superior caval vein|vena cava superior|cranial vena cava	http://purl.obolibrary.org/obo/UBERON_0001585		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0001584	biolink:AnatomicalEntity	left subclavian artery	The subclavian artery that supplies the left pectoral appendage.	NCIT:C32972|MA:0002046|OpenCyc:Mx4rtW7hw6gEEdudWQACs5b6Bw|UMLS:C0226262|EMAPA:37100|OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvp8u1JwpEbGdrcN5Y29ycA|FMA:4694	hp.json	arteria subclavia (sinistra)	http://purl.obolibrary.org/obo/UBERON_0001584		pheno_slim|human_reference_atlas|uberon_slim
HP:0008383	biolink:PhenotypicFeature	Slow-growing nails	Nails whose growth is slower than normal.	UMLS:C1835238	hp.json	Slow-growing nails	http://purl.obolibrary.org/obo/HP_0008383		
UBERON:0001568	biolink:AnatomicalEntity	muscle of larynx	The muscles associated with the larynx.	NCIT:C32934|MA:0001768|FMA:46562|EMAPA:35473|Wikipedia:Muscles_of_larynx|UMLS:C0023054|GAID:144|BTO:0001626|SCTID:181744001|MESH:D007821	hp.json	musculi laryngeales|muscle organ of larynx|larynx muscle organ|larynx muscle|laryngeal muscle	http://purl.obolibrary.org/obo/UBERON_0001568		pheno_slim
HP:0200032	biolink:PhenotypicFeature	Kayser-Fleischer ring	Grey-green or brownish-pigmented ring in the deep epithelial layers at the outer border of the cornea.	SNOMEDCT_US:77103006|UMLS:C0152457	hp.json	Fleischer-Struempell ring|Fleischer's ring|Fleischer-Kayser ring	http://purl.obolibrary.org/obo/HP_0200032		
HP:0200030	biolink:PhenotypicFeature	Punctate vasculitis skin lesions		UMLS:C3277693	hp.json		http://purl.obolibrary.org/obo/HP_0200030		
HP:0033301	biolink:PhenotypicFeature	Elevated circulating 1-methylhistidine concentration	An abnormally increased level of 1-methylhistidine in the blood circulation. 1-methylhistidine is a derivative of L-histidine.		hp.json		http://purl.obolibrary.org/obo/HP_0033301		
HP:0200037	biolink:PhenotypicFeature	Skin vesicle	A circumscribed, fluid-containing, epidermal elevation generally considered less than 10mm in diameter at the widest point.	UMLS:C3814530	hp.json		http://purl.obolibrary.org/obo/HP_0200037		
HP:0033300	biolink:PhenotypicFeature	Increased circulating complement factor H related protein 1 concentration	Elevated level of circulating complement factor H related protein 1 concentration in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033300		
HP:0200036	biolink:PhenotypicFeature	Skin nodule	Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat.	SNOMEDCT_US:95319004|UMLS:C0037287	hp.json	Growth of abnormal tissue on or under the skin	http://purl.obolibrary.org/obo/HP_0200036		
HP:0200035	biolink:PhenotypicFeature	Skin plaque	A plaque is a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter.	UMLS:C0241148|SNOMEDCT_US:276322001|SNOMEDCT_US:128177006	hp.json		http://purl.obolibrary.org/obo/HP_0200035		
HP:0033303	biolink:PhenotypicFeature	Elevated urinary monocarboxylic acid level	Abnormally increased amount of a monocarboxylic acid in the urine. Monocarboxylic acids are molecules with one COOH functional group.		hp.json		http://purl.obolibrary.org/obo/HP_0033303		
HP:0200034	biolink:PhenotypicFeature	Papule	A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point.	SNOMEDCT_US:443871003|UMLS:C0332563|MEDDRA:10033733|SNOMEDCT_US:25694009	hp.json	Skin papules|Papules	http://purl.obolibrary.org/obo/HP_0200034		hposlim_core
HP:0033302	biolink:PhenotypicFeature	Elevated circulating 4-hydroxyphenylacetic acid concentration	An abnormally increased concentration of 4-Hydroxyphenylacetic acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033302		
GO:0048601	biolink:BiologicalProcess	oocyte morphogenesis	The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte.		hp.json	oocyte morphogenesis during differentiation	http://purl.obolibrary.org/obo/GO_0048601		
HP:0200039	biolink:PhenotypicFeature	Pustule	A small elevation of the skin containing cloudy or purulent material usually consisting of necrotic inflammatory cells.	SNOMEDCT_US:47002008|SNOMEDCT_US:271760008|UMLS:C0241157|UMLS:C0542346|SNOMEDCT_US:103605005|MEDDRA:10037578|SNOMEDCT_US:285305004	hp.json	Pustular lesion|Skin pustules|Pimple|Pustules|Skin pustule|Pustula	http://purl.obolibrary.org/obo/HP_0200039		hposlim_core
HP:0033309	biolink:PhenotypicFeature	Ileoileal intussusception	A type of intussusception of the small intestine in which one part of the ileum invaginates (telescopes) into another part of the ileum.		hp.json		http://purl.obolibrary.org/obo/HP_0033309		
HP:0033308	biolink:PhenotypicFeature	Patellar overgrowth	Excessive growth of the kneecap (patella).		hp.json		http://purl.obolibrary.org/obo/HP_0033308		
CHEBI:38700	biolink:ChemicalSubstance	organic sodium salt			hp.json		http://purl.obolibrary.org/obo/CHEBI_38700		
GO:0048609	biolink:BiologicalProcess	multicellular organismal reproductive process	The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.		hp.json	reproductive process in a multicellular organism|organismal reproductive process	http://purl.obolibrary.org/obo/GO_0048609		
GO:0048608	biolink:BiologicalProcess	reproductive structure development	The reproductive developmental process whose specific outcome is the progression of somatic structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures.		hp.json		http://purl.obolibrary.org/obo/GO_0048608		
HP:0033305	biolink:PhenotypicFeature	Abnormal circulating fetuin A concentration	Any deviation from the normal concentration of fetuin A in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033305		
HP:0033304	biolink:PhenotypicFeature	obsolete Elevated urine 4-hydroxyphenylacetic acid level			hp.json		http://purl.obolibrary.org/obo/HP_0033304		
HP:0033307	biolink:PhenotypicFeature	Increased circulating fetuin A concentration	An elevation above normal of fetuin A in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033307		
HP:0033306	biolink:PhenotypicFeature	Decreased circulating fetuin A concentration	A reduction below normal of fetuin A in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033306		
UBERON:0001576	biolink:AnatomicalEntity	intrinsic muscle of tongue	The intrinsic tongue muscles are an integral part of the tongue and completely contained within the tongue that are innervated by Cranial Nerve XII.	EHDAA:9152|VHOG:0000748|FMA:46701|SCTID:244788005|EHDAA2:0002064|EMAPA:18280|MA:0002327	hp.json	intrinsic tongue muscle|intrinsic lingual muscle	http://purl.obolibrary.org/obo/UBERON_0001576		
UBERON:0001575	biolink:AnatomicalEntity	extrinsic muscle of tongue	A muscle organ that attaches the tongue to some other structure.	SCTID:244782006|VHOG:0000825|EMAPA:18275|MA:0002296|EHDAA:9148|FMA:46699|EHDAA2:0002063	hp.json	extrinsic lingual muscle|extrinsic tongue muscle	http://purl.obolibrary.org/obo/UBERON_0001575		
CHEBI:75771	biolink:ChemicalSubstance	mouse metabolite	Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).		hp.json	Mus musculus metabolite|mouse metabolites|Mus musculus metabolites	http://purl.obolibrary.org/obo/CHEBI_75771		3_STAR
UBERON:0001578	biolink:AnatomicalEntity	orbicularis oculi muscle	A circumorbital muscle in the face that closes the eyelid[HP].	NCIT:C52886|UMLS:C0224122|EMAPA:35619|MA:0001254|FMA:46779	hp.json	tensor tarsi|musculus orbicularis oculi|orbicularis oculi	http://purl.obolibrary.org/obo/UBERON_0001578		pheno_slim|uberon_slim
UBERON:0001577	biolink:AnatomicalEntity	facial muscle	A muscle innervated by a facial nerve.	XAO:0001013|GAID:143|MFMO:0000005|UMLS:C0015460|MA:0003160|NCIT:C13073|FMA:46751|MESH:D005152	hp.json	mimetic muscles|cranial-facial muscle|facial nerve innervated muscle|facial muscle proper|muscle of facil expression|facial nerve muscle|facial muscle|cranio-facial muscle|muscle organ of face|musculi faciei|muscle of face|face muscle organ|facial muscle|muscles of facial expression|face muscle|craniofacial muscle	http://purl.obolibrary.org/obo/UBERON_0001577		pheno_slim|uberon_slim
UBERON:0001572	biolink:AnatomicalEntity	hyoglossus muscle	A muscle that attaches to the hyopid bone and to the tongue and is innervated by cranial nerve XII.	FMA:46691|SCTID:244785008|EMAPA:18277|AAO:0010663|NCIT:C53161|Wikipedia:Hyoglossus_muscle|UMLS:C0224196|MA:0002317|MFMO:0000064	hp.json	hyoglossus|hyoglossus|m. hyoglossus	http://purl.obolibrary.org/obo/UBERON_0001572		uberon_slim
HP:0008373	biolink:PhenotypicFeature	Puberty and gonadal disorders		UMLS:C4024685	hp.json	Puberty and gonadal disorders	http://purl.obolibrary.org/obo/HP_0008373		
UBERON:0001571	biolink:AnatomicalEntity	genioglossus muscle	Either of a pair of lingual muscles with origin in the mandible, with insertion to the lingual fascia below the mucous membrane and epiglottis, with nerve supply from the hypoglossal nerve, and whose action depresses and protrudes the tongue.	EHDAA:9150|Wikipedia:Genioglossus_muscle|UMLS:C0224194|VHOG:0000847|SCTID:244784007|FMA:46690|EMAPA:18276|NCIT:C52928|AAO:0010660|EHDAA2:0000704|MA:0002307	hp.json	musculus genioglossus|genioglossus|m. genioglossus	http://purl.obolibrary.org/obo/UBERON_0001571		uberon_slim
UBERON:0001574	biolink:AnatomicalEntity	palatoglossus muscle	The palatoglossus, glossopalatinus, or palatoglossal muscle is a small fleshy fasciculus, narrower in the middle than at either end, forming, with the mucous membrane covering its surface, the glossopalatine arch. It arises from the anterior surface of the soft palate, where it is continuous with the muscle of the opposite side, and passing downward, forward, and lateralward in front of the palatine tonsil, is inserted into the side of the tongue, some of its fibers spreading over the dorsum, and others passing deeply into the substance of the organ to intermingle with the Transversus linguæ. [WP,unvetted].	EMAPA:18278|UMLS:C1704249|MA:0002351|NCIT:C53170|FMA:46697	hp.json	palatoglossal muscle|palatoglossus|musculus palatoglossus|palatoglossal	http://purl.obolibrary.org/obo/UBERON_0001574		uberon_slim
HP:0008376	biolink:PhenotypicFeature	Nasal, dysarthic speech		UMLS:C1834664	hp.json	Breathy speech	http://purl.obolibrary.org/obo/HP_0008376		
CHEBI:75772	biolink:ChemicalSubstance	Saccharomyces cerevisiae metabolite	Any  fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae).		hp.json	S. cerevisiae secondary metabolites|baker's yeast metabolites|S. cerevisiae metabolites|S. cerevisiae metabolite|Saccharomyces cerevisiae secondary metabolites|baker's yeast metabolite|S. cerevisiae secondary metabolite|Saccharomyces cerevisiae metabolites|baker's yeast secondary metabolites|baker's yeast secondary metabolite	http://purl.obolibrary.org/obo/CHEBI_75772		3_STAR
UBERON:0001573	biolink:AnatomicalEntity	styloglossus	The Styloglossus, the shortest and smallest of the three styloid muscles, arises from the anterior and lateral surfaces of the styloid process, near its apex, and from the stylomandibular ligament. Passing downward and forward between the internal and external carotid arteries, it divides upon the side of the tongue near its dorsal surface, blending with the fibers of the Longitudinalis inferior in front of the Hyoglossus; the other, oblique, overlaps the Hyoglossus and decussates with its fibers. [WP,unvetted].	EMAPA:18279|FMA:46692|MA:0002387|NCIT:C53071|UMLS:C0224195	hp.json	musculus styloglossus|syloglossus muscle	http://purl.obolibrary.org/obo/UBERON_0001573		uberon_slim
PR:000001969	biolink:Protein	urokinase plasminogen activator surface receptor	A protein that is a translation product of the human PLAUR gene or a 1:1 ortholog thereof.	PIRSF:PIRSF002022	hp.json	PLAUR|UPAR|CD87|uPAR|monocyte activation antigen Mo3|U-PAR|MO3	http://purl.obolibrary.org/obo/PR_000001969		
HP:0200040	biolink:PhenotypicFeature	Epidermoid cyst	Nontender, round and firm, but slightly compressible, intradermal or subcutaneous cyst measuring 0.5-5 cm in diameter. Epidermal cysts are intradermal or subcutaneous tumors, grow slowly and occur on the face, neck, back and scrotum. They usually appear at or around puberty, and as a rule an affected individual has one solitary or a few cysts.	SNOMEDCT_US:419893006|SNOMEDCT_US:419670003|UMLS:C0014511|SNOMEDCT_US:417992006|SNOMEDCT_US:399999000|SNOMEDCT_US:418630001|MSH:D004814|SNOMEDCT_US:418323001|SNOMEDCT_US:419603000	hp.json	Infundibular cyst|Sebaceous cyst|Keratin cyst|Epidermoid cysts|Epidermal inclusion cyst|Epidermal cyst|Skin cyst	http://purl.obolibrary.org/obo/HP_0200040		
HP:0008392	biolink:PhenotypicFeature	Subungual hyperkeratosis	A thickening of the stratum corneum in the region beneath the nails.	SNOMEDCT_US:10165000|UMLS:C0038605	hp.json	Thickened, discolored skin under nail|Thickened, discoloured skin under nail	http://purl.obolibrary.org/obo/HP_0008392		
HP:0008391	biolink:PhenotypicFeature	Dystrophic fingernails	The presence of misshapen or partially destroyed nail plates, often with accumulation of soft, yellow keratin between the dystrophic nail plate and nail bed, resulting in elevation of the nail plate.	UMLS:C3551426	hp.json	Poor fingernail formation	http://purl.obolibrary.org/obo/HP_0008391		
CHEBI:75787	biolink:ChemicalSubstance	prokaryotic metabolite	Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea.		hp.json	prokaryotic metabolites	http://purl.obolibrary.org/obo/CHEBI_75787		3_STAR
HP:0008394	biolink:PhenotypicFeature	Congenital onychodystrophy		UMLS:C4280413|UMLS:C1393669	hp.json	Congenital malformed nails	http://purl.obolibrary.org/obo/HP_0008394		
HP:0008393	biolink:PhenotypicFeature	Congenital curved nail of fourth toe		UMLS:C4024684	hp.json		http://purl.obolibrary.org/obo/HP_0008393		
UBERON:0001558	biolink:AnatomicalEntity	lower respiratory tract	The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified].	SCTID:281488008|FMA:45662|OpenCyc:Mx4rQRqjUgAKEdyHxgDggVfs8g|MA:0000435|Wikipedia:Lower_respiratory_tract|VHOG:0000382|EHDAA2:0001036|EMAPA:16738	hp.json	lower respiratory system	http://purl.obolibrary.org/obo/UBERON_0001558		uberon_slim|pheno_slim
HP:0200044	biolink:PhenotypicFeature	Porokeratosis	A clonal disorder of keratinization with one or multiple atrophic patches surrounded by a clinically and histologically distinctive hyperkeratotic ridgelike border called the cornoid lamella.	MSH:D017499|UMLS:C0949506|SNOMEDCT_US:80432009	hp.json		http://purl.obolibrary.org/obo/HP_0200044		
UBERON:0001557	biolink:AnatomicalEntity	upper respiratory tract	The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea.	EMAPA:17669|FMA:45661|OpenCyc:Mx4rtT2HwgJMEdyAAADggVbxzQ|MA:0000442|VHOG:0000406|EHDAA2:0002136	hp.json		http://purl.obolibrary.org/obo/UBERON_0001557		uberon_slim|pheno_slim
HP:0200043	biolink:PhenotypicFeature	Verrucae	Warts, benign growths on the skin or mucous membranes that cause cosmetic problems as well as pain and discomfort. Warts most often occur on the hands, feet, and genital areas.	MSH:D014860|UMLS:C3665596|SNOMEDCT_US:30285000|SNOMEDCT_US:57019003	hp.json	Warts	http://purl.obolibrary.org/obo/HP_0200043		
HP:0008390	biolink:PhenotypicFeature	Recurrent loss of toenails and fingernails	Repeated loss, or shedding, of the nails of the fingers and toes.	UMLS:C4021542	hp.json	Recurrent shedding of toenails and fingernails|Recurrent loss of toenails and fingernails	http://purl.obolibrary.org/obo/HP_0008390		
HP:0200042	biolink:PhenotypicFeature	Skin ulcer	A discontinuity of the skin exhibiting complete loss of the epidermis and often portions of the dermis and even subcutaneous fat.	SNOMEDCT_US:46742003|UMLS:C0037299|MEDDRA:10040943|MSH:D012883	hp.json	Open skin sore	http://purl.obolibrary.org/obo/HP_0200042		hposlim_core
HP:0200041	biolink:PhenotypicFeature	Skin erosion	A discontinuity of the skin exhibiting incomplete loss of the epidermis, a lesion that is moist, circumscribed, and usually depressed.	UMLS:C3887524|MEDDRA:10040840|SNOMEDCT_US:93448009	hp.json		http://purl.obolibrary.org/obo/HP_0200041		
HP:0200048	biolink:PhenotypicFeature	Cyanotic episode		UMLS:C0578475|SNOMEDCT_US:301795004	hp.json		http://purl.obolibrary.org/obo/HP_0200048		
HP:0033312	biolink:PhenotypicFeature	Abnormal Bowman space morphology	Structural anomaly located in Bowman's space, which represents the beginning of the urinary space and is contiguous with the proximal convoluted tubule of the nephron.		hp.json		http://purl.obolibrary.org/obo/HP_0033312		
HP:0033311	biolink:PhenotypicFeature	Abdominal aortic dissection	A tear in the intimal layer of the abdominal aorta causing a separation between the intima and the medial layers.		hp.json		http://purl.obolibrary.org/obo/HP_0033311		
HP:0200047	biolink:PhenotypicFeature	Chondritis of pinna	Inflammation of the cartilage of the external ear.	UMLS:C0741305	hp.json	Inflammation of cartilage of pinna	http://purl.obolibrary.org/obo/HP_0200047		
HP:0200046	biolink:PhenotypicFeature	Cat cry	The presence of a characteristic high-pitched cry that sounds similar to the meowing of a kitten.	UMLS:C0234861|SNOMEDCT_US:42712003	hp.json	cat-like cry|cri de chat-associated cry|Cat cry	http://purl.obolibrary.org/obo/HP_0200046		
HP:0033314	biolink:PhenotypicFeature	Visceral epithelial cell hyperplasia	Increased number of visceral epithelial cells (2 or more layers), often with crowding and multilayering, but without continuity with the parietal epithelium.		hp.json	Hyperplasia of visceral epithelial cells|Podocyte hyperplasia	http://purl.obolibrary.org/obo/HP_0033314		
HP:0033313	biolink:PhenotypicFeature	Urinary space collagenization	Acellular collagenous matrix within Bowman's space, not associated with extracapillary hypercellularity or necrosis, associated with sclerosis or deflation of the tuft.		hp.json	Collagenization of the urinary space	http://purl.obolibrary.org/obo/HP_0033313		
CHEBI:38717	biolink:ChemicalSubstance	carboxylic acid trianion	A trianion containing at least one carboxy group.		hp.json	carboxylic acid trianions|carboxylic acid trianion	http://purl.obolibrary.org/obo/CHEBI_38717		3_STAR
CHEBI:12109	biolink:ChemicalSubstance	5-aminolevulinate		Beilstein:3937762	hp.json	5-amino-4-oxopentanoate	http://purl.obolibrary.org/obo/CHEBI_12109		3_STAR
HP:0033310	biolink:PhenotypicFeature	Osmotic diarrhea	Osmotic diarrhea results from the presence of osmotically active, poorly absorbed solutes in the bowel lumen that inhibit normal water and electrolyte absorption.		hp.json		http://purl.obolibrary.org/obo/HP_0033310		
HP:0200049	biolink:PhenotypicFeature	Upper limb hypertonia	Increased muscle tone observed in the arms of the affected person.	UMLS:C4021898	hp.json		http://purl.obolibrary.org/obo/HP_0200049		
HP:0033319	biolink:PhenotypicFeature	Fibrous crescent	A type of glomerular crescent characterized by extracapillary fibrosis composed of greater than 75% matrix and of less than 25% cells with or without fibrin, usually associated with disruption of Bowman's capsule and involving over 10% of the capsular circumference.		hp.json		http://purl.obolibrary.org/obo/HP_0033319		
CHEBI:38716	biolink:ChemicalSubstance	carboxylic acid dianion	Any dianion containing at least one carboxy group.		hp.json	carboxylic acid dianions|carboxylic acid dianion	http://purl.obolibrary.org/obo/CHEBI_38716		3_STAR
HP:0033316	biolink:PhenotypicFeature	Glomerular crescent formation	Glomerular crescent refers hyperplastic lesions involving 10% or more of the circumference of Bowman's capsule. Crescents can be composed of a variable mixture of epithelial/leukocyte hypercellularity, fibrous matrix, and fibrin.		hp.json		http://purl.obolibrary.org/obo/HP_0033316		
PR:000001971	biolink:Protein	vascular endothelial growth factor receptor	A protein with core architecture consisting of a signal sequence, followed by 7 Ig-like domains (Pfam:PF00047, Pfam:PF07679, or Pfam:PF07686), a transmembrane region, and a cytoplasmic Protein tyrosine kinase domain.	PIRSF:PIRSF038502	hp.json		http://purl.obolibrary.org/obo/PR_000001971		
HP:0033315	biolink:PhenotypicFeature	Visceral epithelial hyaline droplets	Round to ovoid, Periodic acid-Schiff (PAS)-positive, fuchsinophilic cytoplasmic inclusions within visceral epithelial cells.		hp.json		http://purl.obolibrary.org/obo/HP_0033315		
HP:0033318	biolink:PhenotypicFeature	Fibrocellular crescent	A type of glomerular crescent characterized by extracapillary hypercellularity of more than 2 cell layers and involving over 10% of the capsular circumference, composed of 25% to 75% cells with or without fibrin, and the remainder fibrous matrix.		hp.json		http://purl.obolibrary.org/obo/HP_0033318		
HP:0033317	biolink:PhenotypicFeature	Cellular crescent	A type of glomerular crescent characterized by extracapillary hypercellularity of greater than two cell layers and involving more than 10% of the capsular circumference, composed of greater than 75% cells with or without fibrin, and less than 25% fibrous matrix.		hp.json		http://purl.obolibrary.org/obo/HP_0033317		
UBERON:0001565	biolink:AnatomicalEntity	geniohyoid muscle	The geniohyoid is a muscle that attaches to the mandible and the hyoid apparatus and is innervated by the first cervical nerve (C1).	NCIT:C52930|UMLS:C0224160|EMAPA:36626|FMA:46325|MA:0002308	hp.json	genio-hyoideus|m. geniohyoideus|genio-hyoideus muscle|musculus geniohyoideus|geniohyoid|geniohyoideus muscle|geniohyoideus	http://purl.obolibrary.org/obo/UBERON_0001565		uberon_slim
UBERON:0001564	biolink:AnatomicalEntity	mylohyoid muscle	The mylohyoid is a pharyngeal arch I muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to mylohyoid and attaches to the midline raphe linking right and left mylohyoid and the mandible.	FMA:46320|NCIT:C52962|MFMO:0000084|MA:0002344|UMLS:C0224159|EMAPA:25136	hp.json	mylohyoid|mylohyoideus|mylohyoideus muscle|musculus mylohyoideus|musculus mylohyoideus	http://purl.obolibrary.org/obo/UBERON_0001564		uberon_slim
HP:0008388	biolink:PhenotypicFeature	Abnormal toenail morphology	An anomaly of the toenail.	SNOMEDCT_US:700189007|UMLS:C3839753	hp.json	Abnormality of the toenail|Abnormality of the toenails	http://purl.obolibrary.org/obo/HP_0008388		
UBERON:0001567	biolink:AnatomicalEntity	cheek	A fleshy subdivision of one side of the face bounded by an eye, ear and the nose.	FMA:46476|OpenCyc:Mx4rvVi5WZwpEbGdrcN5Y29ycA|NCIT:C13070|MA:0002475|MESH:D002610|TAO:0002113|UMLS:C0007966|BTO:0001754|galen:Cheek|GAID:65|EMAPA:37451	hp.json	buccae|jowl	http://purl.obolibrary.org/obo/UBERON_0001567		uberon_slim|pheno_slim
UBERON:0001566	biolink:AnatomicalEntity	cricothyroid muscle	Intrinsic muscle of the larynx, innervated by the external division of the laryngeal nerve, a branch of the vagus nerve. It attaches to the anterolateral surface of the cricoid cartilage and the external surface of the thyroid cartilage.	NCIT:C32404|FMA:46417|MA:0002284|MFMO:0000324|EMAPA:19270|UMLS:C0224178	hp.json	M. cricothyroideus|cricothyroideus|musculus cricothyroideus|cricothyroid	http://purl.obolibrary.org/obo/UBERON_0001566		uberon_slim
UBERON:0001560	biolink:AnatomicalEntity	neck of organ		FMA:45733	hp.json	organ neck	http://purl.obolibrary.org/obo/UBERON_0001560		non_informative
CHEBI:26739	biolink:ChemicalSubstance	sphingolipid	Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone.		hp.json	sphingolipids	http://purl.obolibrary.org/obo/CHEBI_26739		3_STAR
UBERON:0001562	biolink:AnatomicalEntity	digastric muscle group	A group of muscles (or in some classifications, muscle bellies) that are located under the jaw and attach to the base of the cranium and typically attaches to the hyoid apparatus via a common tendon.	EMAPA:25134|UMLS:C0224155|MA:0002288|NCIT:C32462|FMA:46291	hp.json	musculus digastricus|digastricus|musculus digastricus|digastric muscle|digastric|digastric	http://purl.obolibrary.org/obo/UBERON_0001562		uberon_slim
HP:0008386	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the nails	Aplasia or developmental hypoplasia of the nail.	UMLS:C1859077	hp.json	Absent/underdeveloped nails|Nail aplasia/hypoplasia|Absent/hypoplastic nails|Absent/small nails	http://purl.obolibrary.org/obo/HP_0008386		
HP:0011930	biolink:PhenotypicFeature	Hyperextensible skin of chest		UMLS:C4021836	hp.json	Stretchable chest skin|Hyperelastic chest skin	http://purl.obolibrary.org/obo/HP_0011930		
HP:0011939	biolink:PhenotypicFeature	3-4 finger cutaneous syndactyly	A soft tissue continuity in the A/P axis between fingers 3 and 4.	UMLS:C4023115	hp.json		http://purl.obolibrary.org/obo/HP_0011939		
GO:0010001	biolink:BiologicalProcess	glial cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.		hp.json	neuroglia differentiation|glia cell differentiation	http://purl.obolibrary.org/obo/GO_0010001		
GO:0010002	biolink:BiologicalProcess	cardioblast differentiation	The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.		hp.json	cardioblast cell differentiation|cardiomyocyte generation|cardiac precursor cell differentiation	http://purl.obolibrary.org/obo/GO_0010002		
HP:0011931	biolink:PhenotypicFeature	Abnormal cerebellar peduncle morphology	An anomaly of the cerebellar peduncles. The superior, middle, and inferior cerebellar peduncles emerge from the cerebellum. The superior cerebellar penduncles connect the cerebellum to the midbrain, the middle cerebellar peduncles connect the cerebellum to the pons, and the inferior cerebellar peduncle connects the medulla spinalis and medulla oblongata with the cerebellum.	UMLS:C4023121	hp.json	Abnormality of the cerebellar peduncle	http://purl.obolibrary.org/obo/HP_0011931		
HP:0011932	biolink:PhenotypicFeature	Abnormal superior cerebellar peduncle morphology	An anomaly of the superior cerebellar peduncle.	UMLS:C4023120	hp.json	Abnormality of the superior cerebellar peduncle	http://purl.obolibrary.org/obo/HP_0011932		
HP:0011933	biolink:PhenotypicFeature	Elongated superior cerebellar peduncle	Increased length of the superior cerebellar peduncle.	UMLS:C4021109|UMLS:C3810214	hp.json	Long cerebellar peduncle|Elongated superior cerebellar peduncles|Long cerebellar peduncles	http://purl.obolibrary.org/obo/HP_0011933		
HP:0011934	biolink:PhenotypicFeature	Dilatation of mesenteric artery	Abnormal outpouching or sac-like dilatation in the wall of the inferior mesenteric artery or superior mesenteric artery .	UMLS:C4023119	hp.json	Mesenteric artery aneurysm	http://purl.obolibrary.org/obo/HP_0011934		
HP:0011935	biolink:PhenotypicFeature	Decreased urinary urate	Decreased concentration of urate in the urine.	UMLS:C4023118	hp.json		http://purl.obolibrary.org/obo/HP_0011935		
HP:0011936	biolink:PhenotypicFeature	Decreased plasma total carnitine	A decreased concentration of total carnitine in the blood.	UMLS:C4023117	hp.json	Decreased plasma total carnitine	http://purl.obolibrary.org/obo/HP_0011936		
HP:0011937	biolink:PhenotypicFeature	Hypoplastic fifth toenail	Underdeveloped nails of the fifth toes.	UMLS:C4023116	hp.json	Small fifth toenail|Underdeveloped fifth toenail	http://purl.obolibrary.org/obo/HP_0011937		
HP:0011928	biolink:PhenotypicFeature	Short proximal phalanx of toe	Developmental hypoplasia (shortening) of proximal phalanx of toe.	UMLS:C4023123	hp.json	Short innermost toe bone	http://purl.obolibrary.org/obo/HP_0011928		
HP:0011929	biolink:PhenotypicFeature	Hypersegmentation of proximal phalanx of third finger	Presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the third finger.	UMLS:C4023122	hp.json		http://purl.obolibrary.org/obo/HP_0011929		
HP:0011920	biolink:PhenotypicFeature	Transudative pleural effusion	A type of pleural effusion with a transudate (extravascular fluid with low protein content and a low specific gravity). Pleural effusions can be classified as transudates or exudates based on Light's criteria, which classify an effusion as exudate if one or more of the following are present: (1) the ratio of pleural fluid protein to serum protein is greater than 0.5, (2) the ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH is greater than 0.6, or (3) the pleural fluid LDH level is greater than two thirds of the upper limit of normal for serum LDH.	SNOMEDCT_US:79231000|UMLS:C0020312|MSH:D006876	hp.json		http://purl.obolibrary.org/obo/HP_0011920		
HP:0011921	biolink:PhenotypicFeature	Exudative pleural effusion	A type of pleural effusion with a exudate (extravascular fluid that has exuded out of a tissue or its capillaries due to injury or inflammation). Pleural effusions can be classified as transudates or exudates based on Light's criteria, which classify an effusion as exudate if one or more of the following are present: (1) the ratio of pleural fluid protein to serum protein is greater than 0.5, (2) the ratio of pleural fluid lactate dehydrogenase (LDH) to serum LDH is greater than 0.6, or (3) the pleural fluid LDH level is greater than two thirds of the upper limit of normal for serum LDH.	SNOMEDCT_US:13841000119107|UMLS:C3887491	hp.json		http://purl.obolibrary.org/obo/HP_0011921		
HP:0011922	biolink:PhenotypicFeature	Abnormal activity of mitochondrial respiratory chain	An increased or decreased activity of the mitochondrial respiratory chain.	UMLS:C4023126	hp.json		http://purl.obolibrary.org/obo/HP_0011922		
HP:0011923	biolink:PhenotypicFeature	Decreased activity of mitochondrial complex I	A reduction in the activity of the mitochondrial respiratory chain complex I, which is part of the electron transport chain in mitochondria.	UMLS:C2677650|UMLS:C4020739	hp.json	Respiratory complex I deficiency	http://purl.obolibrary.org/obo/HP_0011923		
HP:0011924	biolink:PhenotypicFeature	Decreased activity of mitochondrial complex III	A reduction in the activity of the mitochondrial respiratory chain complex III, which is part of the electron transport chain in mitochondria.	UMLS:C4020738|UMLS:C3149083	hp.json	Respiratory complex III deficiency	http://purl.obolibrary.org/obo/HP_0011924		
HP:0011925	biolink:PhenotypicFeature	Decreased activity of mitochondrial ATP synthase complex	A reduction in the activity of the mitochondrial proton-transporting ATP synthase complex, which makes ATP via oxidative phosphorylation, and is sometimes described as Complex V of the electron transport chain.	UMLS:C4020737|UMLS:C4023125	hp.json	Respiratory complex deficiency, ATPase deficiency	http://purl.obolibrary.org/obo/HP_0011925		
HP:0011926	biolink:PhenotypicFeature	Proximal placement of hallux	Proximal mislocalization of the big toe from its normal position.	UMLS:C4021110	hp.json	Proximal placement of big toe|Proximally placed halluces	http://purl.obolibrary.org/obo/HP_0011926		
HP:0011927	biolink:PhenotypicFeature	Short digit	One or more digit that appears disproportionately short compared to the hand/foot, whereby either the entire digit or a specific phalanx is shortened.	UMLS:C1860176|UMLS:C4023124	hp.json	Very short digits|Short digit	http://purl.obolibrary.org/obo/HP_0011927		
GO:0097576	biolink:BiologicalProcess	vacuole fusion	Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole.		hp.json		http://purl.obolibrary.org/obo/GO_0097576		
PR:Q62226	biolink:Protein	sonic hedgehog protein (mouse)	A sonic hedgehog protein that is encoded in the genome of mouse.	UniProtKB:Q62226	hp.json	SHH (mouse)|mSHH|Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (mouse)|Shh|HHG-1 (mouse)|ShhNC (mouse)|Hhg1	http://purl.obolibrary.org/obo/PR_Q62226		
CHEBI:48154	biolink:ChemicalSubstance	sulfur oxide			hp.json	oxides of sulfur|Schwefeloxide|sulfur oxides	http://purl.obolibrary.org/obo/CHEBI_48154		3_STAR
HP:0011917	biolink:PhenotypicFeature	Short 5th toe	Underdevelopment (hypoplasia) of the fifth toe.	UMLS:C4021111	hp.json	Short little toe|Short fifth toe|Short pinkie toe|Short pinky toe	http://purl.obolibrary.org/obo/HP_0011917		
HP:0011918	biolink:PhenotypicFeature	Clinodactyly of the 4th toe	Bending or curvature of a fourth toe in the tibial direction (i.e., towards the big toe).	UMLS:C4020740	hp.json	Curvature of 4th toe|4th toe clinodactyly	http://purl.obolibrary.org/obo/HP_0011918		
HP:0011919	biolink:PhenotypicFeature	Pleural empyema	Accumulation of pus in the pleural cavity.	SNOMEDCT_US:405950009|UMLS:C0014013|SNOMEDCT_US:58554001|SNOMEDCT_US:405951008|MSH:D016724	hp.json	Pyothorax	http://purl.obolibrary.org/obo/HP_0011919		
HP:0011910	biolink:PhenotypicFeature	Shortening of all phalanges of fingers	Abnormal reduction in length affecting all phalanges.	UMLS:C4023133	hp.json	Shortening of all finger bones	http://purl.obolibrary.org/obo/HP_0011910		
HP:0011911	biolink:PhenotypicFeature	Abnormal metacarpophalangeal joint morphology	An anomaly of a metacarpophalangeal joint.	UMLS:C4023132	hp.json	Abnormality of the knuckle|Abnormality of metacarpophalangeal joint	http://purl.obolibrary.org/obo/HP_0011911		
HP:0011912	biolink:PhenotypicFeature	Abnormality of the glenoid fossa	An anomaly of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus.	UMLS:C4023131	hp.json		http://purl.obolibrary.org/obo/HP_0011912		
HP:0011913	biolink:PhenotypicFeature	Lumbar hypertrichosis	Excessive, increased hair growth located in the lumbar region.	UMLS:C4023130	hp.json		http://purl.obolibrary.org/obo/HP_0011913		
HP:0011914	biolink:PhenotypicFeature	Thoracic hypertrichosis	Excessive, increased hair growth located in the thoracic region.	UMLS:C4023129	hp.json		http://purl.obolibrary.org/obo/HP_0011914		
HP:0011915	biolink:PhenotypicFeature	Cardiovascular calcification	Abnormal calcification in the cardiovascular system.	UMLS:C4023128	hp.json		http://purl.obolibrary.org/obo/HP_0011915		
CHEBI:36164	biolink:ChemicalSubstance	amino dicarboxylic acid			hp.json	amino dicarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_36164		3_STAR
HP:0011916	biolink:PhenotypicFeature	Toe extensor amyotrophy	Atrophy of the extensor digitorum longus muscles, which mediate extension of the toes.	UMLS:C4023127	hp.json		http://purl.obolibrary.org/obo/HP_0011916		
CHEBI:145810	biolink:ChemicalSubstance	insulin	A peptide hormone which consists of two polypeptide chains, A- and B- chains which are linked together by disulfide bonds. The amino acid sequence of insulin varies across species and certain segments of the molecule are highly conserved. In most species, the A chain consists of 21 amino acids and the B chain consists of 30 amino acids. In mammals, insulin is synthesised in the pancreas within the beta cells whereas in certain species of fish, the insulin-producing tissue is uniquely located in separate structures called Brockmann bodies.	PMID:6069707|Wikipedia:Insulin|PMID:19251032|PMID:25848166|PMID:5941964|PMID:12137720	hp.json		http://purl.obolibrary.org/obo/CHEBI_145810		3_STAR
HP:0011906	biolink:PhenotypicFeature	Reduced beta/alpha synthesis ratio	A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia.	UMLS:C4023137	hp.json		http://purl.obolibrary.org/obo/HP_0011906		
HP:0011907	biolink:PhenotypicFeature	Reduced alpha/beta synthesis ratio	A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia.	UMLS:C4023136	hp.json		http://purl.obolibrary.org/obo/HP_0011907		
HP:0011908	biolink:PhenotypicFeature	Unilateral radial aplasia	Missing radius bone on one side only associated with congenital failure of development.	UMLS:C4023135	hp.json		http://purl.obolibrary.org/obo/HP_0011908		
HP:0011909	biolink:PhenotypicFeature	Flattened metacarpal heads	Abnormally flat shape of the heads of the metacarpal bones.	UMLS:C4023134	hp.json	Flattened head of long bone of hand	http://purl.obolibrary.org/obo/HP_0011909		
HP:0011900	biolink:PhenotypicFeature	Hypofibrinogenemia	Decreased concentration of fibrinogen in the blood.	UMLS:C0553681|SNOMEDCT_US:234457009	hp.json	Low fibrinogen activity|Low fibrinogen level	http://purl.obolibrary.org/obo/HP_0011900		
HP:0011901	biolink:PhenotypicFeature	Dysfibrinogenemia	Qualitatively abnormal fibrinogen.	SNOMEDCT_US:111589005|UMLS:C1260903	hp.json	Dysfibrinogenaemia	http://purl.obolibrary.org/obo/HP_0011901		
HP:0011902	biolink:PhenotypicFeature	Abnormal hemoglobin	Anomaly in the level or the function of hemoglobin, the oxygen-carrying protein of erythrocytes.	UMLS:C0349705	hp.json	Abnormal Hb|Abnormal haemoglobin	http://purl.obolibrary.org/obo/HP_0011902		
HP:0011903	biolink:PhenotypicFeature	HbH hemoglobin	Hemoglobin H (HbH) contains four beta-globin chains. It is normally not present at all in blood, but may make up about 1-40 percent of all hemoglobin in HbH disease, a subform of alpha thalassemia.	UMLS:C3161174|SNOMEDCT_US:48553001	hp.json	HbH haemoglobin|Hemoglobin H|Haemoglobin H	http://purl.obolibrary.org/obo/HP_0011903		
HP:0011904	biolink:PhenotypicFeature	Persistence of hemoglobin F	Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent.	UMLS:C0239941	hp.json	Persistence of HbF|Persistence of haemoglobin F|Increased haemoglobin F|Increased hemoglobin F	http://purl.obolibrary.org/obo/HP_0011904		
HP:0011905	biolink:PhenotypicFeature	Reduced hemoglobin A	Hemoglobin A (HbA) contains two globin alpha chains and two globin beta chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decreased in the proportion of HbA below this limit, and can be seen in various forms of thalassemia.	UMLS:C4023138	hp.json	Reduced HbA|Reduced haemoglobin A	http://purl.obolibrary.org/obo/HP_0011905		
UBERON:0001507	biolink:AnatomicalEntity	biceps brachii	A muscle in the forelimb stylopod which in humans has several functions, the most important being to rotate the forearm and to flex the elbow. [WP,unvetted].	MA:0002269|BTO:0003419|FMA:37670|NCIT:C32200|EHDAA2:0000167|EHDAA:8279|UMLS:C0559499|VHOG:0000861|EMAPA:19108	hp.json	biceps|musculus biceps brachii|biceps muscle|biceps cubiti|biceps brachii muscle|biceps brachii %26 brachialis muscles	http://purl.obolibrary.org/obo/UBERON_0001507		pheno_slim|uberon_slim
UBERON:0001509	biolink:AnatomicalEntity	triceps brachii	The triceps brachii muscle (Latin for 'three-headed' muscle of the arm, it is called a three headed muscle because there are three bundles of muscle, each of different origin, joining together at the elbow) is the large muscle on the back of the human upper limb. It is the muscle principally responsible for extension of the elbow joint (i.e. straightening of the arm). Though a similarly-named muscle, the triceps surae, is found on the lower leg, the triceps brachii is commonly called simply the 'triceps'. [WP,unvetted].	EHDAA2:0002080|MA:0002399|NCIT:C90604|EMAPA:19111|VHOG:0000851|UMLS:C0559502|EHDAA:8287|FMA:37688|NCIT:C33812	hp.json	musculus triceps brachii|triceps|triceps muscle|triceps brachii muscle	http://purl.obolibrary.org/obo/UBERON_0001509		pheno_slim|uberon_slim
HP:0011970	biolink:PhenotypicFeature	Cerebral amyloid angiopathy	Amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system.	MSH:D016657|UMLS:C0085220|SNOMEDCT_US:230724001	hp.json		http://purl.obolibrary.org/obo/HP_0011970		
UBERON:0001508	biolink:AnatomicalEntity	arch of aorta	The convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery.	SCTID:181300001|VHOG:0001196|MA:0000475|EFO:0002526|GAID:471|EHDAA2:0000132|FMA:3768|BTO:0000157|EMAPA:17613|Wikipedia:Arch_of_aorta	hp.json	thoracic aorta|arcus aortae|aortic arch	http://purl.obolibrary.org/obo/UBERON_0001508		pheno_slim|human_reference_atlas|uberon_slim
HP:0011971	biolink:PhenotypicFeature	Dermatographic urticaria	An exaggerated whealing tendency when the skin is stroked, that is, formation of red, itchy bumps and lines on the skin as a result of pressure on the skin (for instance, stroking the skin with a pen or tongue depressor).	UMLS:C0343065|SNOMEDCT_US:402410006|SNOMEDCT_US:7632005|SNOMEDCT_US:402601007	hp.json	Skin writing|Dermographism|Dermatographism	http://purl.obolibrary.org/obo/HP_0011971		
UBERON:0001503	biolink:AnatomicalEntity	dorsal interosseous of manus	The dorsal interossei of the hand are muscles that occupy the space between the metacarpals. There are four dorsal interossei in each hand. They are specified as 'dorsal' to contrast them with the palmar interossei, which are located on the anterior side of the metacarpals. The dorsal interosseous muscles are bipennate, with each muscle arising by two heads from the adjacent sides of the metacarpal bones, but more extensively from the metacarpal bone of the finger into which the muscle is inserted. They are inserted into the bases of the proximal phalanges and into the extensor expansion of the corresponding extensor digitorum tendon. The middle digit has two dorsal interossei insert onto it while the first digit (thumb) and the fifth digit (little finger) have none[WP].	FMA:37418|NCIT:C52703|EMAPA:37519|MA:0002314|UMLS:C1744530	hp.json	dorsal interosseous muscle of hand|dorsal interosseous of hand|dorsal manus interosseous muscle|musculi interossei dorsales manus|dorsal hand interosseus muscle	http://purl.obolibrary.org/obo/UBERON_0001503		
UBERON:0001502	biolink:AnatomicalEntity	interosseous muscle of manus	Any of the interosseous muscles of the manus (hand). This includes the dorsal and plantar interossei.	UMLS:C0224295|FMA:37417|NCIT:C53173|EMAPA:36216|MA:0002313	hp.json	hand interosseous muscle|interosseous muscle of hand|manus interosseous muscle	http://purl.obolibrary.org/obo/UBERON_0001502		pheno_slim
HP:0011972	biolink:PhenotypicFeature	Hypoglycorrhachia	Abnormally low glucose concentration in the cerebrospinal fluid.	UMLS:C0598121	hp.json	Decreased CSF glucose|Low glucose levels in cerebral spinal fluid	http://purl.obolibrary.org/obo/HP_0011972		
HP:0011973	biolink:PhenotypicFeature	Paroxysmal lethargy	Repeated episodes of sudden-onset and transient lethargy.	UMLS:C1847507	hp.json		http://purl.obolibrary.org/obo/HP_0011973		
HP:0011974	biolink:PhenotypicFeature	Myelofibrosis	Replacement of bone marrow by fibrous tissue.	UMLS:C0026987|SNOMEDCT_US:52967002	hp.json		http://purl.obolibrary.org/obo/HP_0011974		
CHEBI:24163	biolink:ChemicalSubstance	galactoside			hp.json	galactosides|galactoside	http://purl.obolibrary.org/obo/CHEBI_24163		3_STAR
CHEBI:36149	biolink:ChemicalSubstance	2-hydroxyglutarate(1-)	A dicarboxylic acid monoanion resulting from the removal of a proton from one of the carboxylic acid groups of 2-hydroxyglutaric acid.		hp.json	hydrogen 2-hydroxypentanedioate	http://purl.obolibrary.org/obo/CHEBI_36149		3_STAR
CHEBI:36147	biolink:ChemicalSubstance	oxo dicarboxylate			hp.json	oxo dicarboxylates|oxo-dicarboxylic acid dianion|oxo-dicarboxylic acid dianions	http://purl.obolibrary.org/obo/CHEBI_36147		3_STAR
HP:0008316	biolink:PhenotypicFeature	Abnormal mitochondria in muscle tissue	An abnormality of the mitochondria in muscle tissue.	UMLS:C4021546	hp.json	Abnormal mitochondria in muscle	http://purl.obolibrary.org/obo/HP_0008316		
HP:0008315	biolink:PhenotypicFeature	Decreased plasma free carnitine	A decreased concentration of free (unbound) carnitine in the blood.	UMLS:C4015009	hp.json		http://purl.obolibrary.org/obo/HP_0008315		
HP:0008318	biolink:PhenotypicFeature	Elevated leukocyte alkaline phosphatase	Increased alkaline phosphatase measured within leukocytes.	UMLS:C4024704	hp.json	Elevated leukocyte ALP	http://purl.obolibrary.org/obo/HP_0008318		
UBERON:0001510	biolink:AnatomicalEntity	skin of knee	A zone of skin that is part of a knee [Automatically generated definition].	EMAPA:18151|NCIT:C64859|FMA:37800|UMLS:C0222275|MA:0000668	hp.json	knee zone of skin|zone of skin of knee|knee skin	http://purl.obolibrary.org/obo/UBERON_0001510		
HP:0011975	biolink:PhenotypicFeature	Aminoglycoside-induced hearing loss	Partial or complete loss of hearing following ingestion of aminoglycoside antibiotics.	UMLS:C4023100	hp.json		http://purl.obolibrary.org/obo/HP_0011975		
HP:0011976	biolink:PhenotypicFeature	Elevated urinary catecholamines	An increased concentration of catecholamine in the urine.	UMLS:C0241577	hp.json	Elevated urinary catecholamines	http://purl.obolibrary.org/obo/HP_0011976		
CHEBI:36141	biolink:ChemicalSubstance	quinone	Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included).	Wikipedia:Quinone	hp.json	Chinon|quinones|quinones|quinone	http://purl.obolibrary.org/obo/CHEBI_36141		3_STAR
HP:0008311	biolink:PhenotypicFeature	Spinal cord posterior columns myelin loss		UMLS:C4024706	hp.json		http://purl.obolibrary.org/obo/HP_0008311		
UBERON:0001512	biolink:AnatomicalEntity	skin of ankle	A zone of skin that is part of an ankle [Automatically generated definition].	EMAPA:37353|FMA:37831|UMLS:C0222286|NCIT:C52751|MA:0000641	hp.json	ankle skin|zone of skin of ankle|ankle zone of skin|tarsal region skin	http://purl.obolibrary.org/obo/UBERON_0001512		
HP:0011977	biolink:PhenotypicFeature	Elevated urinary homovanillic acid	An increased concentration of homovanillic acid in the urine.	UMLS:C4020736	hp.json	Increased urinary homovanillic acid	http://purl.obolibrary.org/obo/HP_0011977		
HP:0008314	biolink:PhenotypicFeature	Decreased activity of mitochondrial complex II	A reduction in the activity of the mitochondrial respiratory chain complex II, which is part of the electron transport chain in mitochondria.	UMLS:C4020801|UMLS:C4024705	hp.json	Respiratory complex II deficiency	http://purl.obolibrary.org/obo/HP_0008314		
UBERON:0001511	biolink:AnatomicalEntity	skin of leg	A zone of skin that is part of a leg [Automatically generated definition].	NCIT:C52749|EMAPA:37352|EMAPA:18159|MA:0000674|EMAPA:18156|FMA:37828|UMLS:C0222279	hp.json	leg zone of skin|zone of skin of leg|leg skin	http://purl.obolibrary.org/obo/UBERON_0001511		
HP:0011978	biolink:PhenotypicFeature	Elevated urinary vanillylmandelic acid	An increased concentration of vanillylmandelic acid in the urine.	UMLS:C4020735	hp.json	Increased urinary vanillylmandelic acid	http://purl.obolibrary.org/obo/HP_0011978		
HP:0011979	biolink:PhenotypicFeature	Elevated urinary dopamine	An increased concentration of dopamine in the urine.	UMLS:C4023099	hp.json	Elevated urinary dopamine	http://purl.obolibrary.org/obo/HP_0011979		
CHEBI:36145	biolink:ChemicalSubstance	oxo dicarboxylic acid	Any dicarboxylic acid carrying one or more oxo groups.		hp.json	oxo dicarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_36145		3_STAR
HP:0011960	biolink:PhenotypicFeature	Substantia nigra gliosis	Focal proliferation of glial cells in the substantia nigra.	UMLS:C1846865	hp.json		http://purl.obolibrary.org/obo/HP_0011960		
HP:0011961	biolink:PhenotypicFeature	Non-obstructive azoospermia	Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy.	UMLS:C4021107	hp.json	Testicular azoospermia	http://purl.obolibrary.org/obo/HP_0011961		
HP:0011962	biolink:PhenotypicFeature	Obstructive azoospermia	Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy.	UMLS:C4023106	hp.json		http://purl.obolibrary.org/obo/HP_0011962		
HP:0011963	biolink:PhenotypicFeature	Pretesticular azoospermia	Absence of any measurable level of sperm in his semen, due to a hypothalamic or pituitary abnormality diagnosed with hypo-gonadotropic-hypogonadism. The diagnosis is made on the basis of low LH and FSH levels and low or normal testosterone levels.	UMLS:C4023105	hp.json		http://purl.obolibrary.org/obo/HP_0011963		
HP:0008327	biolink:PhenotypicFeature	Microscopic nephrocalcinosis	The presence of microscopic crystalline calcium precipitates in the form of oxalate and/or phosphate in the renal parenchyma.	UMLS:C0403474|SNOMEDCT_US:236444003	hp.json		http://purl.obolibrary.org/obo/HP_0008327		
HP:0008326	biolink:PhenotypicFeature	Reduced circulating vitamin B6 level	An abnormally decreased concentration of vitamin B6 in the blood circulation.	MSH:D026681|UMLS:C0936215|SNOMEDCT_US:386080007	hp.json	Reduced vitamin b6 levels|Vitamin B6 deficiency	http://purl.obolibrary.org/obo/HP_0008326		
HP:0011964	biolink:PhenotypicFeature	Intermittent painful muscle spasms	History of repeated intermittent involuntary muscle contractions that were painful.	UMLS:C4023104	hp.json		http://purl.obolibrary.org/obo/HP_0011964		
HP:0008323	biolink:PhenotypicFeature	Abnormal light- and dark-adapted electroretinogram	An abnormality of the combined rod-and-cone response on electroretinogram.	UMLS:C3151111	hp.json	Abnormal rod and cone electroretinogram	http://purl.obolibrary.org/obo/HP_0008323		
HP:0008322	biolink:PhenotypicFeature	Abnormal mitochondrial morphology	Any structural anomaly of the mitochondria.	UMLS:C4014650	hp.json	Abnormal mitochondrion morphology	http://purl.obolibrary.org/obo/HP_0008322		
HP:0011965	biolink:PhenotypicFeature	Abnormal circulating citrulline concentration	Any deviation from the normal concentration of citrulline in the blood circulation.	UMLS:C4023103	hp.json		http://purl.obolibrary.org/obo/HP_0011965		
HP:0011966	biolink:PhenotypicFeature	Elevated plasma citrulline	An increased concentration of citrulline in the blood.	UMLS:C4023102	hp.json		http://purl.obolibrary.org/obo/HP_0011966		
UBERON:0001500	biolink:AnatomicalEntity	muscle of manus	Any muscle organ that is part of a manus [Automatically generated definition].	EMAPA:32644|MA:0000628|FMA:37372	hp.json	manus muscle organ|manus muscle|muscle of hand|muscle organ of manus|hand muscle	http://purl.obolibrary.org/obo/UBERON_0001500		
HP:0011967	biolink:PhenotypicFeature	Decreased circulating copper concentration	A reduced concentration of copper in the blood.	SNOMEDCT_US:19577007|UMLS:C0268070	hp.json	Hypocupremia|Reduced serum copper|Copper deficiency	http://purl.obolibrary.org/obo/HP_0011967		
HP:0011968	biolink:PhenotypicFeature	Feeding difficulties	Impaired ability to eat related to problems gathering food and getting ready to suck, chew, or swallow it.	UMLS:C0232466|SNOMEDCT_US:78164000	hp.json	Poor feeding|Feeding difficulties|Feeding problems	http://purl.obolibrary.org/obo/HP_0011968		hposlim_core
HP:0011969	biolink:PhenotypicFeature	Elevated circulating luteinizing hormone level	An elevated concentration of luteinizing hormone in the blood.	UMLS:C4023101	hp.json	Elevated LH level|Elevated luteinizing hormone|Increased circulating luteinizing hormone level	http://purl.obolibrary.org/obo/HP_0011969		
HP:0008321	biolink:PhenotypicFeature	Reduced factor X activity	Reduced activity of coagulation factor X. The extrinsic and intrinsic pathways converge at factor X (fX). The extrinsic pathway activates fX by means of d factor VII with its cofactor, tissue factor. The intrinsic pathway activates fX by means of the tenase complex (Ca2+ and factors VIIIa, IXa and X) on the surface of activated platelets. Factor Xa in turn activates prothrombin (factor II) to thrombin (factor IIa).	SNOMEDCT_US:76642003|UMLS:C4024702|MSH:D005171|UMLS:C0015519	hp.json	Decreased factor x activity|Factor X deficiency	http://purl.obolibrary.org/obo/HP_0008321		
HP:0008320	biolink:PhenotypicFeature	Impaired collagen-induced platelet aggregation	Abnormal response to collagen or collagen-mimetics as manifested by reduced or lacking aggregation of platelets upon addition collagen or collagen-mimetics.	UMLS:C4024703	hp.json		http://purl.obolibrary.org/obo/HP_0008320		
CHEBI:24148	biolink:ChemicalSubstance	galactonate			hp.json		http://purl.obolibrary.org/obo/CHEBI_24148		3_STAR
HP:0011950	biolink:PhenotypicFeature	Bronchiolitis	Inflammation of the bronchioles.	SNOMEDCT_US:4120002|UMLS:C0006271|MSH:D001988	hp.json		http://purl.obolibrary.org/obo/HP_0011950		
HP:0011951	biolink:PhenotypicFeature	Aspiration pneumonia	Pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract.	UMLS:C0032290|MSH:D011015|SNOMEDCT_US:422588002	hp.json		http://purl.obolibrary.org/obo/HP_0011951		
CHEBI:24149	biolink:ChemicalSubstance	galactonic acid	A hexonic acid that has been found to increase in red blood cells of galactosemic patients.	PMID:14680973	hp.json		http://purl.obolibrary.org/obo/CHEBI_24149		3_STAR
HP:0011952	biolink:PhenotypicFeature	Acute aspiration pneumonia	An acute episode of pneumonia due to the aspiration (breathing in) of food, liquid, or gastric contents into the upper respiratory tract.	SNOMEDCT_US:35031000119100|UMLS:C4023111	hp.json		http://purl.obolibrary.org/obo/HP_0011952		
HGNC:553	biolink:Gene	AOX1 (human)	A protein coding gene AOX1 in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=553		
HP:0011953	biolink:PhenotypicFeature	Pulmonary lymphoma	Lung parenchymal involvement with lymphoma.	UMLS:C0519063	hp.json		http://purl.obolibrary.org/obo/HP_0011953		
HP:0011954	biolink:PhenotypicFeature	Nodular regenerative hyperplasia of liver	Diffuse benign transformation of the hepatic parenchyma into small regenerative nodules with minimal or no fibrosis.	SNOMEDCT_US:715140008|UMLS:C1318485|SNOMEDCT_US:65860006	hp.json	Partial nodular transformation of liver|Nodular transformation of liver|Noncirrhotic nodulation	http://purl.obolibrary.org/obo/HP_0011954		
HP:0011955	biolink:PhenotypicFeature	Hepatic granulomatosis	The presence of multiple granulomas in the liver as based on pathological examination. Granulomas are small 0.5 to 2 mm collections of modified macrophages called epithelioid cells usually surrounded by lymphocytes.	UMLS:C4023110	hp.json		http://purl.obolibrary.org/obo/HP_0011955		
HP:0011956	biolink:PhenotypicFeature	Intestinal lymphoid nodular hyperplasia	A lymphoproliferative abnormality of the intestine characterized by numerous visible mucosal nodules measuring up to, and rarely exceeding, 0.5 cm in diameter Histologically, hyperplastic lymphoid follicles with large germinal centres are seen in the lamina propria and superficial submucosa. There is enlargement of the mucosal B cell follicles caused by hyperplasia of the follicle centres; surrounded by a normal appearing mantle zone. Disease may involve the stomach, the entire small intestine, and the large intestine.	UMLS:C4023109	hp.json		http://purl.obolibrary.org/obo/HP_0011956		
HP:0011957	biolink:PhenotypicFeature	Abnormal pectoral muscle morphology	An abnormality of the pectoral muscle, comprising the pectoralis major, a thick, fan-shaped muscle of the anterior chest and the pectoralis minor, a thin, triangular muscle situated underneath the pectoralis major.	UMLS:C4023108	hp.json	Abnormal pec muscles	http://purl.obolibrary.org/obo/HP_0011957		
HP:0011958	biolink:PhenotypicFeature	Retinal perforation	A small hole through the whole thickness of the retina.	SNOMEDCT_US:40024006|SNOMEDCT_US:95690009|SNOMEDCT_US:232003005|MSH:D012167|SNOMEDCT_US:302888003|UMLS:C0035321	hp.json	Torn retina|Retinal tear	http://purl.obolibrary.org/obo/HP_0011958		
HP:0011959	biolink:PhenotypicFeature	Unilateral hypoplasia of pectoralis major muscle	Hypoplasia (underdevelopment) of the pectoralis minor on only one side of the chest.	UMLS:C4023107	hp.json	Small pec muscle on one side|Underdeveloped pec muscle on one side	http://purl.obolibrary.org/obo/HP_0011959		
HP:0011940	biolink:PhenotypicFeature	Anterior wedging of T12	An abnormality of the shape of the thoracic vertebra T12 such that it is wedge-shaped (narrow towards the front).	UMLS:C4021108	hp.json	Wedge-shaped 12th thoracic vertebra|Anterior wedging of the 12th thoracic vertebra	http://purl.obolibrary.org/obo/HP_0011940		
HP:0011941	biolink:PhenotypicFeature	Anterior wedging of L2	An abnormality of the shape of the lumbar vertebra L2 such that it is wedge-shaped (narrow towards the front).	UMLS:C4023114	hp.json		http://purl.obolibrary.org/obo/HP_0011941		
HP:0008309	biolink:PhenotypicFeature	Medium chain dicarboxylic aciduria	An increase in the level of medium chain dicarboxylic acid in the urine.	UMLS:C1860081	hp.json		http://purl.obolibrary.org/obo/HP_0008309		
HP:0008305	biolink:PhenotypicFeature	Exercise-induced myoglobinuria	Presence of myoglobin in the urine following exercise.	UMLS:C1860069|UMLS:C1845155	hp.json	Exercise-induced myoglobinuria in adults	http://purl.obolibrary.org/obo/HP_0008305		
CHEBI:63726	biolink:ChemicalSubstance	neuroprotective agent	Any compound that can be used for the treatment of neurodegenerative disorders.		hp.json	neuroprotective agents|neuroprotectant|neuroprotectants	http://purl.obolibrary.org/obo/CHEBI_63726		3_STAR
HP:0008306	biolink:PhenotypicFeature	Abnormal iron deposition in mitochondria		UMLS:C3151556	hp.json		http://purl.obolibrary.org/obo/HP_0008306		
HP:0011942	biolink:PhenotypicFeature	Increased urinary sulfite	Increased concentration of SO3(2-), i.e., sulfite, in the urine.	UMLS:C1848957	hp.json		http://purl.obolibrary.org/obo/HP_0011942		
HP:0008301	biolink:PhenotypicFeature	Dermatan sulfate excretion in urine	An increased concentration of dermatan sulfate in the urine.	UMLS:C1854774	hp.json	Dermatan sulphate excretion in urine	http://purl.obolibrary.org/obo/HP_0008301		
HP:0011943	biolink:PhenotypicFeature	Increased urinary thiosulfate	Increased concentration of thiosulfate(2-) in the urine.	UMLS:C3148695	hp.json		http://purl.obolibrary.org/obo/HP_0011943		
HP:0011944	biolink:PhenotypicFeature	Small vessel vasculitis	A type of vasculitis (inflammation of blood vessel walls) that affects blood vessels that are smaller than arteries, i.e., arterioles, venules, and capilllaries.	UMLS:C4023113	hp.json		http://purl.obolibrary.org/obo/HP_0011944		
HP:0008303	biolink:PhenotypicFeature	Olivary degeneration	Degeneration of the olivary bodies, prominent oval structures in the medulla oblongata.	UMLS:C4024707	hp.json		http://purl.obolibrary.org/obo/HP_0008303		
HP:0011945	biolink:PhenotypicFeature	Bronchiolitis obliterans organizing pneumonia	Bronchiolitis obliterans organizing pneumonia (BOOP) is and interstitial lung abnormalitiy characterized histopathologically by plugs of granulation tissue lying within small airways, alveolar ducts, and alveoli and by chronic inflammatory cell infiltration in alveolar walls. Patients with BOOP generally present with subacute illness, including shortness of breath, fever, malaise, and weight loss.	SNOMEDCT_US:129458007|MSH:D018549|UMLS:C0242770	hp.json	BOOP|Cryptogenic organising pneumonia|Bronchiolitis obliterans organising pneumonia|Cryptogenic organizing pneumonia	http://purl.obolibrary.org/obo/HP_0011945		
HP:0011946	biolink:PhenotypicFeature	Bronchiolitis obliterans	Inflammation and fibrosis of the bronchioles leading to partial or complete obstruction of these airways.	MSH:D001989|SNOMEDCT_US:40100001|UMLS:C2350875|UMLS:C0006272	hp.json	Constrictive bronchiolitis|Obliterative bronchiolitis	http://purl.obolibrary.org/obo/HP_0011946		
CHEBI:38796	biolink:ChemicalSubstance	pteroates			hp.json		http://purl.obolibrary.org/obo/CHEBI_38796		3_STAR
HP:0011947	biolink:PhenotypicFeature	Respiratory tract infection	An infection of the upper or lower respiratory tract.	UMLS:C0035243|MSH:D012141|SNOMEDCT_US:275498002	hp.json	Respiratory tract infection|Respiratory infections|Respiratory infection	http://purl.obolibrary.org/obo/HP_0011947		
CHEBI:38795	biolink:ChemicalSubstance	pteroic acids			hp.json		http://purl.obolibrary.org/obo/CHEBI_38795		3_STAR
CHEBI:38794	biolink:ChemicalSubstance	pteroic acid		DrugBank:DB04196|CAS:119-24-4	hp.json	Pteroinsaeure|Pteroic acid	http://purl.obolibrary.org/obo/CHEBI_38794		3_STAR
HP:0011948	biolink:PhenotypicFeature	Recurrent acute respiratory tract infection	A history of repeated acute infections of the upper or lower respiratory tract.	UMLS:C1442786	hp.json	Acute respiratory tract infection	http://purl.obolibrary.org/obo/HP_0011948		
CHEBI:38793	biolink:ChemicalSubstance	pteroate			hp.json		http://purl.obolibrary.org/obo/CHEBI_38793		3_STAR
HP:0011949	biolink:PhenotypicFeature	Acute infectious pneumonia	Acute inflammation of the lung due to an infection.	UMLS:C4023112	hp.json		http://purl.obolibrary.org/obo/HP_0011949		
GO:0048585	biolink:BiologicalProcess	negative regulation of response to stimulus	Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.		hp.json	downregulation of response to stimulus|down regulation of response to stimulus|inhibition of response to stimulus|down-regulation of response to stimulus	http://purl.obolibrary.org/obo/GO_0048585		gocheck_do_not_manually_annotate
GO:0048584	biolink:BiologicalProcess	positive regulation of response to stimulus	Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.		hp.json	stimulation of response to stimulus|up-regulation of response to stimulus|activation of response to stimulus|upregulation of response to stimulus|up regulation of response to stimulus	http://purl.obolibrary.org/obo/GO_0048584		gocheck_do_not_manually_annotate
GO:0048583	biolink:BiologicalProcess	regulation of response to stimulus	Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0048583		gocheck_do_not_manually_annotate
GO:0048582	biolink:BiologicalProcess	positive regulation of post-embryonic development	Any process that activates or increases the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.		hp.json	upregulation of post-embryonic development|up regulation of post-embryonic development|stimulation of post-embryonic development|up-regulation of post-embryonic development|activation of post-embryonic development	http://purl.obolibrary.org/obo/GO_0048582		
GO:0048581	biolink:BiologicalProcess	negative regulation of post-embryonic development	Any process that stops, prevents, or reduces the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.		hp.json	down-regulation of post-embryonic development|downregulation of post-embryonic development|down regulation of post-embryonic development|inhibition of post-embryonic development	http://purl.obolibrary.org/obo/GO_0048581		
GO:0048580	biolink:BiologicalProcess	regulation of post-embryonic development	Any process that modulates the frequency, rate or extent of post-embryonic development. Post-embryonic development is defined as the process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0048580		
GO:0048589	biolink:BiologicalProcess	developmental growth	The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.		hp.json		http://purl.obolibrary.org/obo/GO_0048589		
GO:0048588	biolink:BiologicalProcess	developmental cell growth	The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.		hp.json	developmental growth of a unicellular organism	http://purl.obolibrary.org/obo/GO_0048588		
GO:0061560	biolink:BiologicalProcess	cranial ganglion formation	The process that gives rise to a cranial ganglion. This process pertains to the initial formation of a structure from unspecified parts.		hp.json	cranial ganglia formation	http://purl.obolibrary.org/obo/GO_0061560		
GO:0061561	biolink:BiologicalProcess	trigeminal ganglion formation	The process that gives rise to the trigeminal ganglion. This process pertains to the initial formation of a structure from unspecified parts.		hp.json	trigeminal ganglia formation	http://purl.obolibrary.org/obo/GO_0061561		
GO:0061564	biolink:BiologicalProcess	axon development	The progression of an axon over time. Covers axonogenesis (de novo generation of an axon) and axon regeneration (regrowth), as well as processes pertaining to the progression of the axon over time (fasciculation and defasciculation).		hp.json		http://purl.obolibrary.org/obo/GO_0061564		
GO:0097512	biolink:CellularComponent	cardiac myofibril	A cardiac myofibril is a myofibril specific to cardiac muscle cells.		hp.json		http://purl.obolibrary.org/obo/GO_0097512		
GO:0097511	biolink:CellularComponent	dendritic cell dendrite	A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.		hp.json		http://purl.obolibrary.org/obo/GO_0097511		
GO:0048596	biolink:BiologicalProcess	embryonic camera-type eye morphogenesis	The process in which the anatomical structures of the eye are generated and organized during embryonic development.		hp.json	embryonic eye morphogenesis	http://purl.obolibrary.org/obo/GO_0048596		
GO:0048593	biolink:BiologicalProcess	camera-type eye morphogenesis	The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.		hp.json	camera-style eye morphogenesis	http://purl.obolibrary.org/obo/GO_0048593		
GO:0048592	biolink:BiologicalProcess	eye morphogenesis	The process in which the anatomical structures of the eye are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0048592		
GO:1901338	biolink:MolecularActivity	catecholamine binding	Binding to catecholamine.		hp.json		http://purl.obolibrary.org/obo/GO_1901338		
GO:1903999	biolink:BiologicalProcess	negative regulation of eating behavior	Any process that stops, prevents or reduces the frequency, rate or extent of eating behavior.		hp.json	down regulation of eating behavior|inhibition of eating behaviour|down-regulation of eating behaviour|negative regulation of eating behaviour|downregulation of eating behavior|inhibition of eating behavior|downregulation of eating behaviour|down-regulation of eating behavior|down regulation of eating behaviour	http://purl.obolibrary.org/obo/GO_1903999		
GO:1903998	biolink:BiologicalProcess	regulation of eating behavior	Any process that modulates the frequency, rate or extent of eating behavior.		hp.json	regulation of eating behaviour	http://purl.obolibrary.org/obo/GO_1903998		
GO:1901334	biolink:BiologicalProcess	lactone metabolic process	The chemical reactions and pathways involving lactone.		hp.json	lactone metabolism	http://purl.obolibrary.org/obo/GO_1901334		
GO:0048599	biolink:BiologicalProcess	oocyte development	The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0048599		
GO:0061550	biolink:BiologicalProcess	cranial ganglion development	The process whose specific outcome is the progression of a cranial ganglion over time, from its formation to the mature structure.		hp.json	cranial ganglia development	http://purl.obolibrary.org/obo/GO_0061550		
GO:0048598	biolink:BiologicalProcess	embryonic morphogenesis	The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.		hp.json	embryonic anatomical structure morphogenesis	http://purl.obolibrary.org/obo/GO_0048598		
GO:0061551	biolink:BiologicalProcess	trigeminal ganglion development	The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.		hp.json	trigeminal ganglia development	http://purl.obolibrary.org/obo/GO_0061551		
GO:0061552	biolink:BiologicalProcess	ganglion morphogenesis	The process in which the anatomical structures of ganglion are generated and organized.		hp.json	ganglia morphogenesis	http://purl.obolibrary.org/obo/GO_0061552		
GO:0061553	biolink:BiologicalProcess	ganglion maturation	A developmental process, independent of morphogenetic (shape) change, that is required for ganglion to attain its fully functional state.		hp.json	ganglia maturation	http://purl.obolibrary.org/obo/GO_0061553		
GO:0061554	biolink:BiologicalProcess	ganglion formation	The process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts.		hp.json	ganglia formation	http://purl.obolibrary.org/obo/GO_0061554		
GO:0061556	biolink:BiologicalProcess	trigeminal ganglion morphogenesis	The process in which the anatomical structure of a trigeminal ganglion is generated and organized.		hp.json	trigeminal ganglia morphogenesis	http://purl.obolibrary.org/obo/GO_0061556		
GO:0061557	biolink:BiologicalProcess	trigeminal ganglion maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a trigeminal ganglion to attain its fully functional state.		hp.json	trigeminal ganglia maturation	http://purl.obolibrary.org/obo/GO_0061557		
SO:0000704	biolink:SequenceFeature	gene	A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions.		hp.json		http://purl.obolibrary.org/obo/SO_0000704		
GO:0061558	biolink:BiologicalProcess	cranial ganglion maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a cranial ganglion to attain its fully functional state.		hp.json	cranial ganglia maturation	http://purl.obolibrary.org/obo/GO_0061558		
GO:0061559	biolink:BiologicalProcess	cranial ganglion morphogenesis	The process in which the anatomical structure of a cranial ganglion is generated and organized.		hp.json	cranial ganglia morphogenesis	http://purl.obolibrary.org/obo/GO_0061559		
GO:0097529	biolink:BiologicalProcess	myeloid leukocyte migration	The movement of a myeloid leukocyte within or between different tissues and organs of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0097529		
PATO:0005021	biolink:NamedThing	unicuspidate			hp.json		http://purl.obolibrary.org/obo/PATO_0005021		
GO:0061580	biolink:BiologicalProcess	colon epithelial cell migration	The orderly movement of a colonic epithelial cell from one site to another, often during the development of a multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0061580		
GO:1901343	biolink:BiologicalProcess	negative regulation of vasculature development	Any process that stops, prevents or reduces the frequency, rate or extent of vasculature development.		hp.json	negative regulation of vascular system development|down-regulation of vascular system development|down regulation of vascular system development|down-regulation of vasculature development|downregulation of vascular system development|down regulation of vasculature development|inhibition of vasculature development|downregulation of vasculature development|inhibition of vascular system development	http://purl.obolibrary.org/obo/GO_1901343		
GO:0061581	biolink:BiologicalProcess	corneal epithelial cell migration	The orderly movement of a corneal  epithelial cell from one site to another, often during the development of a multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0061581		
GO:0061582	biolink:BiologicalProcess	intestinal epithelial cell migration	The orderly movement of an intestinal epithelial cell from one site to another, often during the development of a multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0061582		
GO:1901342	biolink:BiologicalProcess	regulation of vasculature development	Any process that modulates the frequency, rate or extent of vasculature development.		hp.json	regulation of vascular system development	http://purl.obolibrary.org/obo/GO_1901342		
GO:1901362	biolink:BiologicalProcess	organic cyclic compound biosynthetic process	The chemical reactions and pathways resulting in the formation of organic cyclic compound.		hp.json	organic cyclic compound biosynthesis|organic cyclic compound formation|organic cyclic compound anabolism|organic cyclic compound synthesis	http://purl.obolibrary.org/obo/GO_1901362		
CL:0001200	biolink:Cell	lymphocyte of B lineage, CD19-positive	A lymphocyte of B lineage that is CD19-positive.		hp.json		http://purl.obolibrary.org/obo/CL_0001200		
GO:1901360	biolink:BiologicalProcess	organic cyclic compound metabolic process	The chemical reactions and pathways involving organic cyclic compound.		hp.json	organic cyclic compound metabolism	http://purl.obolibrary.org/obo/GO_1901360		
CL:0001201	biolink:Cell	B cell, CD19-positive	A B cell that is CD19-positive.		hp.json	CD19-positive B cell|B-lymphocyte, CD19-positive|CD19+ B cell|B lymphocyte, CD19-positive|B-cell, CD19-positive	http://purl.obolibrary.org/obo/CL_0001201		
CL:0001204	biolink:Cell	CD4-positive, alpha-beta memory T cell, CD45RO-positive	CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.		hp.json	CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive|CD4-positive, alpha-beta memory T-cell, CD45RO-positive|CD4-positive, alpha-beta memory T-lymphocyte, CD45RO-positive	http://purl.obolibrary.org/obo/CL_0001204		
CL:0001203	biolink:Cell	CD8-positive, alpha-beta memory T cell, CD45RO-positive	A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.		hp.json	CD8-positive, alpha-beta memory T-lymphocyte, CD45RO-positive|CD8-positive, alpha-beta memory T lymphocyte, CD45RO-positive|CD8-positive, alpha-beta memory T-cell, CD45RO-positive	http://purl.obolibrary.org/obo/CL_0001203		
GO:1901363	biolink:MolecularActivity	heterocyclic compound binding	Binding to heterocyclic compound.		hp.json		http://purl.obolibrary.org/obo/GO_1901363		
HGNC:9445	biolink:Gene	PRL (human)	A protein coding gene PRL in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9445		
GO:1901383	biolink:BiologicalProcess	negative regulation of chorionic trophoblast cell proliferation	Any process that stops, prevents or reduces the frequency, rate or extent of chorionic trophoblast cell proliferation.		hp.json	downregulation of chorionic trophoblast cell proliferation|down regulation of chorionic trophoblast cell proliferation|inhibition of chorionic trophoblast cell proliferation|down-regulation of chorionic trophoblast cell proliferation	http://purl.obolibrary.org/obo/GO_1901383		
GO:1901384	biolink:BiologicalProcess	positive regulation of chorionic trophoblast cell proliferation	Any process that activates or increases the frequency, rate or extent of chorionic trophoblast cell proliferation.		hp.json	up regulation of chorionic trophoblast cell proliferation|up-regulation of chorionic trophoblast cell proliferation|activation of chorionic trophoblast cell proliferation|upregulation of chorionic trophoblast cell proliferation	http://purl.obolibrary.org/obo/GO_1901384		
GO:1901382	biolink:BiologicalProcess	regulation of chorionic trophoblast cell proliferation	Any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_1901382		
GO:0097530	biolink:BiologicalProcess	granulocyte migration	The movement of a granulocyte within or between different tissues and organs of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0097530		
GO:0097534	biolink:BiologicalProcess	lymphoid lineage cell migration	The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage.		hp.json	lymphoid lineage restricted progenitor cell migration	http://purl.obolibrary.org/obo/GO_0097534		
HP:0033282	biolink:PhenotypicFeature	Abnormal glomerular basement membrane morphology	Any abnormal sttructure of the glomerular basement membrane.		hp.json		http://purl.obolibrary.org/obo/HP_0033282		
HP:0033281	biolink:PhenotypicFeature	Circulating nucleated red blood cells	The presence of nucleated red blood cells in the peripheral blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033281		
HP:0033284	biolink:PhenotypicFeature	Diffusely thickened glomerular basement membrane	Prominent glomerular basement membrane (GBM) reflecting an diffuse and relativly uniform increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals.		hp.json		http://purl.obolibrary.org/obo/HP_0033284		
GO:1903905	biolink:BiologicalProcess	positive regulation of establishment of T cell polarity	Any process that activates or increases the frequency, rate or extent of establishment of T cell polarity.		hp.json	upregulation of establishment of T-lymphocyte polarity|activation of establishment of T cell polarity|up-regulation of establishment of T cell polarity|up-regulation of T lymphocyte polarization|up-regulation of T-cell polarization|upregulation of establishment of T lymphocyte polarity|up regulation of T lymphocyte polarization|activation of T lymphocyte polarization|up-regulation of T cell polarization|upregulation of establishment of T-cell polarity|up regulation of T-cell polarization|positive regulation of establishment of T-lymphocyte polarity|activation of T-cell polarization|positive regulation of T lymphocyte polarization|positive regulation of T-cell polarization|up regulation of establishment of T-lymphocyte polarity|upregulation of establishment of T cell polarity|up regulation of T cell polarization|positive regulation of establishment of T lymphocyte polarity|positive regulation of establishment of T-cell polarity|activation of T cell polarization|positive regulation of T cell polarization|up-regulation of establishment of T-lymphocyte polarity|upregulation of T lymphocyte polarization|up regulation of establishment of T lymphocyte polarity|activation of establishment of T-lymphocyte polarity|upregulation of T-cell polarization|up regulation of establishment of T-cell polarity|up-regulation of establishment of T lymphocyte polarity|activation of establishment of T lymphocyte polarity|upregulation of T cell polarization|up-regulation of establishment of T-cell polarity|up regulation of establishment of T cell polarity|activation of establishment of T-cell polarity	http://purl.obolibrary.org/obo/GO_1903905		
HP:0033283	biolink:PhenotypicFeature	Segmentally thickened glomerular basement membrane	Prominent glomerular basement membrane (GBM) reflecting a segmental and increase in thickness (subjective estimate) with no evidence of electron dense deposits by EM. Thickening is measured from endothelial to visceral epithelial plasma membrane and mainly attributable to an increase in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations greater than that of the normal mean GBM thickness for health age- and sex matched individuals.		hp.json		http://purl.obolibrary.org/obo/HP_0033283		
GO:1903904	biolink:BiologicalProcess	negative regulation of establishment of T cell polarity	Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity.		hp.json	down regulation of establishment of T-cell polarity|inhibition of T-cell polarization|downregulation of T-cell polarization|inhibition of establishment of T lymphocyte polarity|down-regulation of establishment of T lymphocyte polarity|inhibition of establishment of T-cell polarity|negative regulation of establishment of T lymphocyte polarity|negative regulation of establishment of T-cell polarity|down-regulation of establishment of T-cell polarity|down regulation of establishment of T cell polarity|inhibition of T cell polarization|downregulation of T cell polarization|inhibition of establishment of T cell polarity|down-regulation of establishment of T cell polarity|down-regulation of T lymphocyte polarization|downregulation of establishment of T-lymphocyte polarity|negative regulation of T lymphocyte polarization|negative regulation of T-cell polarization|down-regulation of T-cell polarization|downregulation of establishment of T lymphocyte polarity|down regulation of T lymphocyte polarization|down regulation of establishment of T-lymphocyte polarity|negative regulation of T cell polarization|down regulation of T-cell polarization|downregulation of establishment of T-cell polarity|down-regulation of T cell polarization|inhibition of establishment of T-lymphocyte polarity|down regulation of T cell polarization|downregulation of T lymphocyte polarization|inhibition of T lymphocyte polarization|down-regulation of establishment of T-lymphocyte polarity|negative regulation of establishment of T-lymphocyte polarity|down regulation of establishment of T lymphocyte polarity|downregulation of establishment of T cell polarity	http://purl.obolibrary.org/obo/GO_1903904		
HP:0200011	biolink:PhenotypicFeature	Abnormal length of corpus callosum		UMLS:C4021903	hp.json		http://purl.obolibrary.org/obo/HP_0200011		
GO:1903903	biolink:BiologicalProcess	regulation of establishment of T cell polarity	Any process that modulates the frequency, rate or extent of establishment of T cell polarity.		hp.json	regulation of T cell polarization|regulation of establishment of T-lymphocyte polarity|regulation of establishment of T lymphocyte polarity|regulation of T lymphocyte polarization|regulation of T-cell polarization|regulation of establishment of T-cell polarity	http://purl.obolibrary.org/obo/GO_1903903		
HP:0033280	biolink:PhenotypicFeature	Paratracheal lymphadenopathy	Enlargement of lymph nodes surrounding the trachea.		hp.json		http://purl.obolibrary.org/obo/HP_0033280		
GO:0048505	biolink:BiologicalProcess	regulation of timing of cell differentiation	The process controlling the activation and/or rate at which relatively unspecialized cells acquire specialized features. Any process that modulates the rate, frequency or extent of the XXX at a consistent predetermined time point during its development.		hp.json	timing of cell differentiation	http://purl.obolibrary.org/obo/GO_0048505		
HP:0200015	biolink:PhenotypicFeature	Symmetric great toe depigmentation		UMLS:C4021900	hp.json		http://purl.obolibrary.org/obo/HP_0200015		
HP:0033289	biolink:PhenotypicFeature	Glomerular basement membrane wrinkling	Irregular folding of the glomerular basement membrane with an intact lamina densa.		hp.json		http://purl.obolibrary.org/obo/HP_0033289		
HP:0200013	biolink:PhenotypicFeature	Neoplasm of fatty tissue	A tumor (abnormal growth of tissue) of adipose tissue.	UMLS:C4021901|NCIT:C3262	hp.json	Tumour of fatty tissue|Tumor of fatty tissue	http://purl.obolibrary.org/obo/HP_0200013		
HP:0200012	biolink:PhenotypicFeature	Short corpus callosum		UMLS:C4021902	hp.json		http://purl.obolibrary.org/obo/HP_0200012		
HP:0033286	biolink:PhenotypicFeature	Thickened glomerular basement membranes with electron dense deposits			hp.json		http://purl.obolibrary.org/obo/HP_0033286		
HP:0033285	biolink:PhenotypicFeature	Thickened glomerular basement membranes with no electron dense deposits	Prominent glomerular basement membrane (GBM) reflecting an increase in thickness (subjective estimate) with no evidence of electron dense deposits by electron microscopy.		hp.json		http://purl.obolibrary.org/obo/HP_0033285		
HP:0200018	biolink:PhenotypicFeature	Protanomaly	A type of anomalous trichromacy associated with defective long-wavelength-sensitive (L) cones, causing the sensitivity spectrum to be shifted toward medium wavelengths. This leads to difficulties especially in distinguishing red and green.	SNOMEDCT_US:51445007|MSH:D003117|UMLS:C0155015|UMLS:C3887980	hp.json	Red-weak|Colorblindness, partial, protan series	http://purl.obolibrary.org/obo/HP_0200018		
HP:0033288	biolink:PhenotypicFeature	Glomerular basement membrane spikes			hp.json		http://purl.obolibrary.org/obo/HP_0033288		
HP:0200017	biolink:PhenotypicFeature	Cerebral white matter agenesis	Congenital defect with failure of the development of the cerebral white matter.	UMLS:C1859969	hp.json	White matter agenesis|Agenesis of the cerebral white matter	http://purl.obolibrary.org/obo/HP_0200017		
HP:0200016	biolink:PhenotypicFeature	Acrokeratosis	Overgrowth of the stratum corneum characterized by flesh-coloured or slightly pigmented smooth or warty papules on the upper surface of hands and feet.	UMLS:C0001202|SNOMEDCT_US:46629009	hp.json	Acral keratosis	http://purl.obolibrary.org/obo/HP_0200016		
HP:0033287	biolink:PhenotypicFeature	Glomerular basement membrane lucencies	Lucent zones within the glomerular basement membranes. May reflect remote/resolved deposits.		hp.json		http://purl.obolibrary.org/obo/HP_0033287		
CHEBI:26708	biolink:ChemicalSubstance	sodium atom		Gmelin:16221|WebElements:Na|KEGG:C01330|CAS:7440-23-5	hp.json	sodium|sodium|Natrium|11Na|Na|sodio|natrium	http://purl.obolibrary.org/obo/CHEBI_26708		3_STAR
CHEBI:26712	biolink:ChemicalSubstance	sodium molecular entity			hp.json	sodium molecular entities|sodium compounds	http://purl.obolibrary.org/obo/CHEBI_26712		3_STAR
HP:0033293	biolink:PhenotypicFeature	Glomerular hyaline pseudothrombus	Intracapillary amorphous, eosinophilic material consisting of immune deposits.		hp.json		http://purl.obolibrary.org/obo/HP_0033293		
HP:0033292	biolink:PhenotypicFeature	Glomerular fibrin thrombus	An aggregate of coagulated blood containing fibrin, with or without entrapped cellular elements, within a glomerular capillary lumen.		hp.json		http://purl.obolibrary.org/obo/HP_0033292		
HP:0033295	biolink:PhenotypicFeature	Mesangial Immune complex deposition	Extracellular meangial accumulation of finely granular material corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry; most typically electron-dense although this may decrease with resorption of the deposit.		hp.json		http://purl.obolibrary.org/obo/HP_0033295		
CHEBI:26714	biolink:ChemicalSubstance	sodium salt			hp.json		http://purl.obolibrary.org/obo/CHEBI_26714		
HP:0033294	biolink:PhenotypicFeature	Glomerular lipoprotein thrombus	Intracapillary silver-positive material that is finely vacuolated and laminated, and stains with oil red O on frozen sections.		hp.json		http://purl.obolibrary.org/obo/HP_0033294		
PR:000013883	biolink:Protein	renin	An angiotensinogenase that is a translation product of the human REN gene or a 1:1 ortholog thereof.	IUPHARobj:2413	hp.json	angiotensinogenase|REN	http://purl.obolibrary.org/obo/PR_000013883		
HP:0200022	biolink:PhenotypicFeature	Choroid plexus papilloma	Choroid plexus papilloma is a histologically benign neoplasm located in the ventricular system of the choroid plexus.	NCIT:C3698|SNOMEDCT_US:18021007|UMLS:C0205770|MSH:D020288	hp.json		http://purl.obolibrary.org/obo/HP_0200022		
HP:0200021	biolink:PhenotypicFeature	Down-sloping shoulders	Low set, steeply sloping shoulders.	UMLS:C1856872	hp.json	Rounded, sloping shoulders|Rounded shoulders|Down-sloping shoulders|Sloping shoulders	http://purl.obolibrary.org/obo/HP_0200021		hposlim_core
HP:0200020	biolink:PhenotypicFeature	Corneal erosion	An erosion or abrasion of the cornea's outermost layer of epithelial cells.	UMLS:C0392163|SNOMEDCT_US:50792001	hp.json	Damage to outer layer of the cornea of the eye	http://purl.obolibrary.org/obo/HP_0200020		hposlim_core
HP:0033291	biolink:PhenotypicFeature	Glomerular karyhorrhectic debris	Apoptotic, pyknotic, and fragmented nuclei within the glomerulus.		hp.json		http://purl.obolibrary.org/obo/HP_0033291		
HP:0033290	biolink:PhenotypicFeature	Glomerular subendothelial widening	Expansion of the space between the glomerular endothelium and lamina densa by electron-lucent material.		hp.json		http://purl.obolibrary.org/obo/HP_0033290		
HP:0200026	biolink:PhenotypicFeature	Ocular pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye.	MSH:D058447|UMLS:C0151827|SNOMEDCT_US:41652007	hp.json	Eye pain	http://purl.obolibrary.org/obo/HP_0200026		
GO:0048515	biolink:NamedThing	spermatid differentiation			hp.json		http://purl.obolibrary.org/obo/GO_0048515		
HP:0200025	biolink:PhenotypicFeature	Mandibular pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the mandible.	UMLS:C0236000|SNOMEDCT_US:274667000	hp.json	Lower jaw pain	http://purl.obolibrary.org/obo/HP_0200025		
HP:0200024	biolink:PhenotypicFeature	Premature chromatid separation	The presence of premature sister chromatid segregation.	UMLS:C4021899	hp.json		http://purl.obolibrary.org/obo/HP_0200024		
GO:0048514	biolink:BiologicalProcess	blood vessel morphogenesis	The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.		hp.json		http://purl.obolibrary.org/obo/GO_0048514		
HP:0200023	biolink:PhenotypicFeature	Priapism	A painful and harmful medical condition in which the erect penis doesn't return to its flaccid state, despite the absence of both physical and psychological stimulation, within four hours.	UMLS:C0033117|SNOMEDCT_US:6273006|MSH:D011317	hp.json	hulseyism	http://purl.obolibrary.org/obo/HP_0200023		
GO:0048513	biolink:BiologicalProcess	animal organ development	Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.	Wikipedia:Organogenesis	hp.json	development of an organ|organogenesis	http://purl.obolibrary.org/obo/GO_0048513		
HP:0033297	biolink:PhenotypicFeature	Multinucleated visceral epithelial cells	Visceral epithelial cells with more than two nuclei. Can be observed on light or ultrastructral microscopy.		hp.json	Podocyte multinucleation|Multinucleated podocytes	http://purl.obolibrary.org/obo/HP_0033297		
GO:0048512	biolink:BiologicalProcess	circadian behavior	The specific behavior of an organism that recurs with a regularity of approximately 24 hours.		hp.json	circadian rhythm behavior	http://purl.obolibrary.org/obo/GO_0048512		
HP:0200029	biolink:PhenotypicFeature	Vasculitis in the skin		SNOMEDCT_US:53312001|UMLS:C0262988	hp.json	Cutaneous vasculitis	http://purl.obolibrary.org/obo/HP_0200029		
GO:0048511	biolink:BiologicalProcess	rhythmic process	Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.		hp.json	rhythm	http://purl.obolibrary.org/obo/GO_0048511		goslim_pir
HP:0033296	biolink:PhenotypicFeature	Binucleated visceral epithelial cells	Visceral epithelial cells with 2 nuclei. Can be observed on light or ultrastructral microscopy.		hp.json	Binucleated podocytes	http://purl.obolibrary.org/obo/HP_0033296		
HP:0033299	biolink:PhenotypicFeature	Reduced circulating complement factor H related protein 1 concentration	Decreased level of circulating complement factor H related protein 1 concentration in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033299		
HP:0200028	biolink:PhenotypicFeature	Pretibial myxedema	A diffuse, non-pitting edema and thickening of the skin usually on the anterior aspect of the lower legs spreading to the dorsum of the feet.	UMLS:C0033103|UMLS:C0342554|SNOMEDCT_US:78146007|SNOMEDCT_US:237825005	hp.json	Graves dermopathy	http://purl.obolibrary.org/obo/HP_0200028		
HP:0033298	biolink:PhenotypicFeature	Abnormal circulating complement factor H related protein 1 concentration	A deviation from the normal concentration in blood of factor H-related protein 1 (FHR-1)		hp.json		http://purl.obolibrary.org/obo/HP_0033298		
GO:0048519	biolink:BiologicalProcess	negative regulation of biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.		hp.json	downregulation of biological process|negative regulation of physiological process|down regulation of biological process|inhibition of biological process|down-regulation of biological process	http://purl.obolibrary.org/obo/GO_0048519		gocheck_do_not_annotate
GO:0048518	biolink:BiologicalProcess	positive regulation of biological process	Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.		hp.json	positive regulation of physiological process|up-regulation of biological process|activation of biological process|upregulation of biological process|up regulation of biological process|stimulation of biological process	http://purl.obolibrary.org/obo/GO_0048518		gocheck_do_not_annotate
NCBITaxon:10239	biolink:OrganismalEntity	Viruses			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_10239		
GO:0048523	biolink:BiologicalProcess	negative regulation of cellular process	Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.		hp.json	downregulation of cellular process|down regulation of cellular process|inhibition of cellular process|negative regulation of cellular physiological process|down-regulation of cellular process	http://purl.obolibrary.org/obo/GO_0048523		gocheck_do_not_annotate
GO:0048522	biolink:BiologicalProcess	positive regulation of cellular process	Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.		hp.json	up regulation of cellular process|stimulation of cellular process|activation of cellular process|up-regulation of cellular process|upregulation of cellular process|positive regulation of cellular physiological process	http://purl.obolibrary.org/obo/GO_0048522		gocheck_do_not_annotate
GO:0048521	biolink:BiologicalProcess	negative regulation of behavior	Any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.		hp.json	inhibition of behavior|down-regulation of behavior|downregulation of behavior|down regulation of behavior	http://purl.obolibrary.org/obo/GO_0048521		
GO:0048520	biolink:BiologicalProcess	positive regulation of behavior	Any process that activates or increases the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.		hp.json	upregulation of behavior|up regulation of behavior|stimulation of behavior|up-regulation of behavior|activation of behavior	http://purl.obolibrary.org/obo/GO_0048520		
PR:000001889	biolink:Protein	CD14 molecule	A protein that is a translation product of the human CD14 gene or a 1:1 ortholog thereof.	PIRSF:PIRSF002017	hp.json	monocyte differentiation antigen CD14|myeloid cell-specific leucine-rich glycoprotein|CD14	http://purl.obolibrary.org/obo/PR_000001889		
HP:0008297	biolink:PhenotypicFeature	Transient hyperphenylalaninemia	A condition of not having consistently high levels of phenylalanine in the blood but of experiencing temporary hyperphenylalaninemia following ingestion of large quantities of phenylalanine (for instance, following an oral loading test with phenylalanine).	UMLS:C0268464|SNOMEDCT_US:28575006	hp.json		http://purl.obolibrary.org/obo/HP_0008297		
UBERON:0013581	biolink:AnatomicalEntity	metapodium bone 1	A metapodium bone that is part of a digit 1 plus metapodial segment.		hp.json	metapodium I|metapodium 1	http://purl.obolibrary.org/obo/UBERON_0013581		
UBERON:0013582	biolink:AnatomicalEntity	metapodium bone 2	A metapodium bone that is part of a digit 2 plus metapodial segment.		hp.json	metapodium 2|metapodium II	http://purl.obolibrary.org/obo/UBERON_0013582		
HP:0200000	biolink:PhenotypicFeature	Dysharmonic bone age	Different levels of maturation of different bones.	UMLS:C4020918	hp.json	Dysharmonic skeletal maturation	http://purl.obolibrary.org/obo/HP_0200000		
UBERON:0013587	biolink:AnatomicalEntity	fused metacarpal bones 3 and 4	An element formed from the fusion of metacarpal 3 and metacarpal 4.		hp.json	os metacarpale III et IV|metacarpal 3+4|fused metacarpal 3/4	http://purl.obolibrary.org/obo/UBERON_0013587		
HP:0200003	biolink:PhenotypicFeature	Splayed epiphyses	Flaring (widening) of the epiphysis.	UMLS:C4021906	hp.json	Splayed end part of bone	http://purl.obolibrary.org/obo/HP_0200003		
UBERON:0013588	biolink:AnatomicalEntity	fused metatarsal bones 3 and 4	An element formed from the fusion of metatarsal 3 and metatarsal 4.		hp.json	metatarsal 3+4|fused metatarsal 3/4|os metatarsale III et IV (Ru)	http://purl.obolibrary.org/obo/UBERON_0013588		
HP:0200001	biolink:PhenotypicFeature	Dysharmonic accelerated bone age	A type of dysharmonic skeletal maturation in which there is an acceleration in skeletal maturation whose degree differs markedly in different bones.	UMLS:C4021907	hp.json		http://purl.obolibrary.org/obo/HP_0200001		
HP:0200008	biolink:PhenotypicFeature	Intestinal polyposis	The presence of multiple polyps in the intestine.	UMLS:C0744333|UMLS:C1257915|MSH:D044483	hp.json	Growths in inner lining of intestine|Gastrointestinal polyps|Multiple intestinal polyps	http://purl.obolibrary.org/obo/HP_0200008		
GO:0048534	biolink:BiologicalProcess	hematopoietic or lymphoid organ development	The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation.		hp.json	haemopoietic or lymphoid organ development|hemopoietic or lymphoid organ development|haematopoietic or lymphoid organ development	http://purl.obolibrary.org/obo/GO_0048534		
UBERON:0013583	biolink:AnatomicalEntity	metapodium bone 3	A metapodial bone that is associated with digit III.		hp.json	metapodium III|cannon bone|metapodium 3|metapodial bone III|3rd metapodium bone	http://purl.obolibrary.org/obo/UBERON_0013583		
HP:0200007	biolink:PhenotypicFeature	Abnormal size of the palpebral fissures	An abnormal size of the palpebral fissures for example unusually long or short palpebral fissures.	UMLS:C4280286|UMLS:C4021904	hp.json	Abnormal size of the eyes|Abnormal size of the opening between the eyelids	http://purl.obolibrary.org/obo/HP_0200007		
UBERON:0013584	biolink:AnatomicalEntity	metapodium bone 4	A metapodium bone that is part of a digit 4 plus metapodial segment.		hp.json	metapodium 4|metapodium IV	http://purl.obolibrary.org/obo/UBERON_0013584		
UBERON:0013585	biolink:AnatomicalEntity	metapodium bone 5	A metapodium bone that is part of a digit 5 plus metapodial segment.		hp.json	metapodium V|metapodium 5	http://purl.obolibrary.org/obo/UBERON_0013585		
HP:0200006	biolink:PhenotypicFeature	Slanting of the palpebral fissure		UMLS:C2748932	hp.json	Slanting of the opening between the eyelids	http://purl.obolibrary.org/obo/HP_0200006		
UBERON:0013586	biolink:AnatomicalEntity	fused metapodial bones 3 and 4	An element formed from the fusion of metapodium 3 and metapodium 4 (i.e. either metatarsals 3 and 4 or metacarpals 3 and 4).		hp.json	metapodial 3+4|fused metapodials 3/4|os metapodiale III et IV	http://purl.obolibrary.org/obo/UBERON_0013586		
HP:0200005	biolink:PhenotypicFeature	Abnormal shape of the palpebral fissure	The presence of an abnormal shape of the palpebral fissure.	UMLS:C4021905	hp.json	Abnormal shape of the opening between the eyelids|Abnormal morphology of the palpebral fissure	http://purl.obolibrary.org/obo/HP_0200005		hposlim_core
PR:000001892	biolink:Protein	CD33 molecule	A protein that is a translation product of the human CD33 gene or a 1:1 ortholog thereof.	IUPHARobj:2601	hp.json	CD33|sialic acid-binding Ig-like lectin 3|SIGLEC3|siglec-3|myeloid cell surface antigen CD33|gp67	http://purl.obolibrary.org/obo/PR_000001892		
PR:000001896	biolink:Protein	natural killer cell receptor 2B4	A protein that is a translation product of the human CD244 gene or a 1:1 ortholog thereof.		hp.json	NAIL|NK cell type I receptor protein 2B4|SLAMF4|CD244|SLAM family member 4|NKR2B4|non-MHC restricted killing associated|signaling lymphocytic activation molecule 4|Nmrk|NK cell activation-inducing ligand|2B4	http://purl.obolibrary.org/obo/PR_000001896		
GO:0048539	biolink:BiologicalProcess	bone marrow development	The process whose specific outcome is the progression of the bone marrow over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0048539		
PR:000001898	biolink:Protein	neprilysin	A protein that is a translation product of the human MME gene or a 1:1 ortholog thereof.	PIRSF:PIRSF501074|IUPHARobj:1611	hp.json	atriopeptidase|EPN|NEP|skin fibroblast elastase|enkephalinase|MME|CALLA|SFE|neutral endopeptidase|CD10|neutral endopeptidase 24.11|common acute lymphocytic leukemia antigen	http://purl.obolibrary.org/obo/PR_000001898		
HP:0033240	biolink:PhenotypicFeature	Elevated RV/TLC ratio	An increase in the ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and (3) body plethysmography. An elevated RV/TLC can be interpreted as a sign of air trapping and hyperinflation.		hp.json	Overinflation on pulmonary function test|Hyperinflation on pulmonary function test	http://purl.obolibrary.org/obo/HP_0033240		
HP:0033246	biolink:PhenotypicFeature	Type II pneumocyte hypertrophy	Increase in size of type II pneumocytes, characterized by qualitative morphologic alterations, including cuboidal shapes, increased nucleocytoplasmic ratio, enlarged nuclei, prominent nucleoli, and various alterations in their nuclear chromatin.		hp.json	Hypertrophic alveolar type II pneumocytes|Hypertrophic alveolar type II cells	http://purl.obolibrary.org/obo/HP_0033246		
HP:0033245	biolink:PhenotypicFeature	Abnormal alveolar type II pneumocyte morphology	Any structural abnormality of alveolar type 2 (ATII) cells.		hp.json	Abnormal type II pneumocyte morphology|Abnormal alveolar epithelial type II cell morphology|Abnormal pulmonary type II cell morphology	http://purl.obolibrary.org/obo/HP_0033245		
HP:0033248	biolink:PhenotypicFeature	Multiple pulmonary interstitial hyalinized nodules	Fibrosing nodules, consisting of either unilateral or bilateral central whorled deposits of lamellar collagen hyalin.		hp.json		http://purl.obolibrary.org/obo/HP_0033248		
GO:1903942	biolink:BiologicalProcess	positive regulation of respiratory gaseous exchange	Any process that activates or increases the frequency, rate or extent of respiratory gaseous exchange.		hp.json	up-regulation of respiratory gaseous exchange|activation of respiratory gaseous exchange|upregulation of respiratory gaseous exchange|up regulation of respiratory gaseous exchange	http://purl.obolibrary.org/obo/GO_1903942		
GO:1903941	biolink:BiologicalProcess	negative regulation of respiratory gaseous exchange	Any process that stops, prevents or reduces the frequency, rate or extent of respiratory gaseous exchange.		hp.json	downregulation of respiratory gaseous exchange|down regulation of respiratory gaseous exchange|inhibition of respiratory gaseous exchange|down-regulation of respiratory gaseous exchange	http://purl.obolibrary.org/obo/GO_1903941		
GO:0048546	biolink:BiologicalProcess	digestive tract morphogenesis	The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed.		hp.json	intestinal morphogenesis|alimentary canal morphogenesis|gastrointestinal tract morphogenesis|gut morphogenesis|digestive tube morphogenesis	http://purl.obolibrary.org/obo/GO_0048546		
HP:0033247	biolink:PhenotypicFeature	Pulmonary amyloidosis	Extracellular deposition in lung tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding.		hp.json		http://purl.obolibrary.org/obo/HP_0033247		
HP:0033242	biolink:PhenotypicFeature	Horseshoe lung	A horseshoe lung is an uncommon congenital abnormality caused by the partial fusion of the bases of both lungs behind the pericardial sac.		hp.json		http://purl.obolibrary.org/obo/HP_0033242		
GO:0048545	biolink:BiologicalProcess	response to steroid hormone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.		hp.json	response to steroid hormone stimulus	http://purl.obolibrary.org/obo/GO_0048545		
HP:0033241	biolink:PhenotypicFeature	Polyalveolar lobe	An elevation of the total count of alveoli as determined by microscopic point-counting of randomly taken lung sections, not secondary to abnormalities in number, size and structure of the airways. In polyaveolar lobe, the number of alveoli is generally increased three to fivefold.		hp.json		http://purl.obolibrary.org/obo/HP_0033241		
HP:0033244	biolink:PhenotypicFeature	Glycogen accumulation in pulmonary interstitial cells	Accumulation of immature interstitial cells containing abundant cytoplasmic glycogen defined by periodic acid-Schiff (PAS) positive cells.		hp.json		http://purl.obolibrary.org/obo/HP_0033244		
HP:0033243	biolink:PhenotypicFeature	Pulmonary necrosis	Cellular death affecting one or more parts of the lung. Necrosis is caused by diverse external and internal factors which result in the unregulated digestion of cell components.		hp.json		http://purl.obolibrary.org/obo/HP_0033243		
GO:0061523	biolink:BiologicalProcess	cilium disassembly	A cellular process that results in the breakdown of a cilium.		hp.json	cilium resorption	http://purl.obolibrary.org/obo/GO_0061523		
HP:0033249	biolink:PhenotypicFeature	Focal substantia nigra T2 hyperintensity	Hyperintense lesion in the substantia nigra on magnetic resonance T2 imaging.		hp.json	Focal substantia nigra T2 hyperintense lesion	http://purl.obolibrary.org/obo/HP_0033249		
GO:0061525	biolink:BiologicalProcess	hindgut development	The process whose specific outcome is the progression of the hindgut over time, from its formation to the mature structure. The hindgut is part of the alimentary canal that lies posterior to the midgut.		hp.json		http://purl.obolibrary.org/obo/GO_0061525		
HP:0033251	biolink:PhenotypicFeature	Elevated residual volume	Increase in the amount of air remaining in a person's lungs after full exhalation.		hp.json	Elevated RV	http://purl.obolibrary.org/obo/HP_0033251		
HP:0033250	biolink:PhenotypicFeature	Nailfold capillary tortuosity	An increased number of turns of the blood vessels of the nailfold with a charactereistic winded or twisted appearance of the blood vessels.		hp.json		http://purl.obolibrary.org/obo/HP_0033250		
GO:1903959	biolink:BiologicalProcess	regulation of anion transmembrane transport	Any process that modulates the frequency, rate or extent of anion transmembrane transport.		hp.json		http://purl.obolibrary.org/obo/GO_1903959		
HP:0033257	biolink:PhenotypicFeature	Delayed ability to walk with support	A failure to achieve the ability to walk with support (cruise) at an appropriate developmental stage.		hp.json	Delayed ability to cruise	http://purl.obolibrary.org/obo/HP_0033257		
HP:0033256	biolink:PhenotypicFeature	Pancolitis	Inflammation of the entire colon.		hp.json		http://purl.obolibrary.org/obo/HP_0033256		
HP:0033259	biolink:PhenotypicFeature	Non-motor seizure	A seizure with clinical manifestation but without motor signs (other than possible behavior arrest) as its initial clinical manifestation. The electrographic onset may be generalized, focal, or unknown.		hp.json		http://purl.obolibrary.org/obo/HP_0033259		
HP:0033258	biolink:PhenotypicFeature	Sudden unexpected death in epilepsy	Sudden unexpected death in epilepsy (SUDEP) is a sudden, unexpected, witnessed or unwitnessed, non-traumatic and non-drowning death, occurring in benign circumstances, in an individual with epilepsy, with or without evidence for a seizure and excluding documented status epilepticus, in which postmortem examination has not revealed a cause of death.		hp.json	SUDEP	http://purl.obolibrary.org/obo/HP_0033258		
GO:1903951	biolink:BiologicalProcess	positive regulation of AV node cell action potential	Any process that activates or increases the frequency, rate or extent of AV node cell action potential.		hp.json	positive regulation of atrioventricular node cardiac muscle cell action potential|up-regulation of AV node cell action potential|upregulation of AV node cardiac muscle cell action potential|up regulation of atrioventricular node cardiac muscle cell action potential|up regulation of AV node cell action potential|activation of AV node cell action potential|up-regulation of atrioventricular node cardiac muscle cell action potential|positive regulation of AV node cardiac muscle cell action potential|activation of atrioventricular node cardiac muscle cell action potential|up regulation of AV node cardiac muscle cell action potential|upregulation of AV node cell action potential|up-regulation of AV node cardiac muscle cell action potential|activation of AV node cardiac muscle cell action potential|upregulation of atrioventricular node cardiac muscle cell action potential	http://purl.obolibrary.org/obo/GO_1903951		
HP:0033253	biolink:PhenotypicFeature	Reduced circulating interferon gamma	A reduction in the concentration of interferon gamma measured in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033253		
GO:1903950	biolink:BiologicalProcess	negative regulation of AV node cell action potential	Any process that stops, prevents or reduces the frequency, rate or extent of AV node cell action potential.		hp.json	inhibition of AV node cell action potential|inhibition of AV node cardiac muscle cell action potential|downregulation of AV node cell action potential|negative regulation of AV node cardiac muscle cell action potential|down-regulation of AV node cardiac muscle cell action potential|downregulation of atrioventricular node cardiac muscle cell action potential|down regulation of atrioventricular node cardiac muscle cell action potential|down-regulation of AV node cell action potential|downregulation of AV node cardiac muscle cell action potential|inhibition of atrioventricular node cardiac muscle cell action potential|negative regulation of atrioventricular node cardiac muscle cell action potential|down-regulation of atrioventricular node cardiac muscle cell action potential|down regulation of AV node cell action potential|down regulation of AV node cardiac muscle cell action potential	http://purl.obolibrary.org/obo/GO_1903950		
HP:0033252	biolink:PhenotypicFeature	Palmar hyperlinearity	Exaggerated skin markings (dermatoglyphics) on the palms of the hand.		hp.json		http://purl.obolibrary.org/obo/HP_0033252		
HP:0033255	biolink:PhenotypicFeature	Congenital lobar overinflation	A congenital malformation characterized by an overdistended segment of lung, affecting an party of a lobe or the entire one. It results in progressive overinflation of one or more lobes.		hp.json	Congenital lobar emphysema	http://purl.obolibrary.org/obo/HP_0033255		
HP:0033254	biolink:PhenotypicFeature	Anorectal stricture	Narrowing of the anorectum associated with inflammation or scar tissue.		hp.json	Stricture of the anorectum	http://purl.obolibrary.org/obo/HP_0033254		
GO:0061512	biolink:BiologicalProcess	protein localization to cilium	A process in which a protein is transported to, or maintained in, a location within a cilium.		hp.json		http://purl.obolibrary.org/obo/GO_0061512		
GO:0061515	biolink:BiologicalProcess	myeloid cell development	The process whose specific outcome is the progression of a myeloid cell over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0061515		
GO:0061519	biolink:BiologicalProcess	macrophage homeostasis	The process of regulating the proliferation and elimination of macrophage cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0061519		
HP:0033260	biolink:PhenotypicFeature	Livedo racemosa	Livedo racemosa describes a reddish-blue mottling of the skin in an irregular, reticular pattern. It differs from the more common livedo reticularis by its shape. Livedo racemosa consists of broken circular segments resulting in a seemingly larger pattern, as opposed to the fine, regular, complete network of livedo reticularis. Livedo racemosa results from permanent impairment of peripheral blood flow and, unlike livedo reticularis, it persists on warming.		hp.json		http://purl.obolibrary.org/obo/HP_0033260		
GO:0048562	biolink:BiologicalProcess	embryonic organ morphogenesis	Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.		hp.json		http://purl.obolibrary.org/obo/GO_0048562		
HP:0033262	biolink:PhenotypicFeature	Transphyseal fracture of the distal humerus	A fracture through the distal humeral physis that separates the entire distal humeral epiphysis from the metaphysis.		hp.json	Transphyseal distal humerus fracture	http://purl.obolibrary.org/obo/HP_0033262		
HP:0033261	biolink:PhenotypicFeature	Renal artery aneurysm	Increase in diameter of a segment of the renal artery that can be defined as a focal, isolated dilatation of all three layers of the arterial wall over 1.5 times the diameter of the disease-free proximal adjacent arterial segment.		hp.json		http://purl.obolibrary.org/obo/HP_0033261		
HP:0033268	biolink:PhenotypicFeature	Deflation of the glomerular tuft	Wrinkling and folding of the capillaries without epithelial cell (podocyte) hyperplasia (formerly called ischemic type of collapse) involving o 80% of the glomerular tuft. The wrinkling is generally made by small regular folds of the glomerular basement membrane.		hp.json		http://purl.obolibrary.org/obo/HP_0033268		
HP:0033267	biolink:PhenotypicFeature	Abnormal glomerular capillary lumen morphology	Abnormal structural characteristics of the interior space of the capillary of the renal glomerulus.		hp.json		http://purl.obolibrary.org/obo/HP_0033267		
HP:0033269	biolink:PhenotypicFeature	Glomerular capillary collapse	Collapse is generally accompanied by other descriptors such as hypertrophy and hyperplasia of overlying glomerular epithelial cells, halo, protein droplets in podocytes and glomerular parietal epithelial cells (PECs).		hp.json	Collapse of glomerular capillary walls	http://purl.obolibrary.org/obo/HP_0033269		
GO:0048568	biolink:BiologicalProcess	embryonic organ development	Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.		hp.json	embryonic organogenesis	http://purl.obolibrary.org/obo/GO_0048568		
HP:0033264	biolink:PhenotypicFeature	Enlarged platelet dense granules	Increased size of platelet dense granules.		hp.json		http://purl.obolibrary.org/obo/HP_0033264		
GO:1903961	biolink:BiologicalProcess	positive regulation of anion transmembrane transport	Any process that activates or increases the frequency, rate or extent of anion transmembrane transport.		hp.json	up-regulation of anion transmembrane transport|up regulation of anion transmembrane transport|activation of anion transmembrane transport|upregulation of anion transmembrane transport	http://purl.obolibrary.org/obo/GO_1903961		
HP:0033263	biolink:PhenotypicFeature	Absent platelet dense granules	Lack of platelet dense granules, a type of platelet organelles.		hp.json	Absent platelet dense bodies	http://purl.obolibrary.org/obo/HP_0033263		
GO:0048565	biolink:BiologicalProcess	digestive tract development	The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.		hp.json	gut development|intestine development|intestinal development	http://purl.obolibrary.org/obo/GO_0048565		
HP:0033266	biolink:PhenotypicFeature	Glomerular pseudocrescent	Visceral epithelial cell hyperplasia with resulting cellular crowding of the the urinary space. In contrast with true crescents, these proliferations lack inflammatory cells and fibrin. The cells are typically plump (not spindle-shaped) and often vacuolated, and Bowman's capsule is usually intact.		hp.json		http://purl.obolibrary.org/obo/HP_0033266		
GO:1903960	biolink:BiologicalProcess	negative regulation of anion transmembrane transport	Any process that stops, prevents or reduces the frequency, rate or extent of anion transmembrane transport.		hp.json	down-regulation of anion transmembrane transport|down regulation of anion transmembrane transport|inhibition of anion transmembrane transport|downregulation of anion transmembrane transport	http://purl.obolibrary.org/obo/GO_1903960		
HP:0033265	biolink:PhenotypicFeature	Podocyte myelin figures	Lamellated intracytoplasmic lipid inclusions within podocytes.		hp.json	Podocyte myelin inclusions	http://purl.obolibrary.org/obo/HP_0033265		
GO:0061548	biolink:BiologicalProcess	ganglion development	The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.		hp.json	gangliogenesis|ganglia development	http://purl.obolibrary.org/obo/GO_0061548		
GO:0061549	biolink:BiologicalProcess	sympathetic ganglion development	The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.		hp.json	sympathetic ganglia development	http://purl.obolibrary.org/obo/GO_0061549		
HP:0033271	biolink:PhenotypicFeature	Glomerular capillary microaneurysm	Glomerular capillary dilatation due to loosening/detachment of the glomerular basement membrane (GBM) from its anchoring points, usually in the context of mesangiolysis or nodular glomerulosclerosis.		hp.json		http://purl.obolibrary.org/obo/HP_0033271		
HP:0033270	biolink:PhenotypicFeature	Glomerular capillary congestion	Global distention of glomerular capillaries with intraluminal intact red blood cells.		hp.json	Glomerular congestion	http://purl.obolibrary.org/obo/HP_0033270		
HP:0033273	biolink:PhenotypicFeature	Loss of glomerular endothelial cell fenestration	Loss of round to oval discontinuities normally present in the glomerular capillary endothelial cell cytoplasm.		hp.json		http://purl.obolibrary.org/obo/HP_0033273		
HP:0033272	biolink:PhenotypicFeature	Abnormal glomerular endothelial cell morphology	An abnormal structure of the glomerular endothelial cells, which are highly specialized cells with fenestrae and a charged luminal glycocalyx layer that contribute to the filtration barrier.		hp.json		http://purl.obolibrary.org/obo/HP_0033272		
GO:0048570	biolink:BiologicalProcess	notochord morphogenesis	The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.		hp.json		http://purl.obolibrary.org/obo/GO_0048570		
GO:1901318	biolink:NamedThing	negative regulation of flagellated sperm motility			hp.json		http://purl.obolibrary.org/obo/GO_1901318		
GO:1901317	biolink:NamedThing	regulation of flagellated sperm motility			hp.json		http://purl.obolibrary.org/obo/GO_1901317		
GO:1903977	biolink:BiologicalProcess	positive regulation of glial cell migration	Any process that activates or increases the frequency, rate or extent of glial cell migration.		hp.json	up regulation of glial cell migration|activation of glia cell migration|positive regulation of glia cell migration|up-regulation of glial cell migration|upregulation of glia cell migration|activation of glial cell migration|upregulation of glial cell migration|up-regulation of glia cell migration|up regulation of glia cell migration	http://purl.obolibrary.org/obo/GO_1903977		
HP:0033279	biolink:PhenotypicFeature	Enterocutaneous fistula	An abnormal connection (fistula) between the intra-abdominal intestinal tract and the skin.		hp.json		http://purl.obolibrary.org/obo/HP_0033279		
HP:0033278	biolink:PhenotypicFeature	Reduced CD95-induced lymphocyte apoptosis	Reduced amount of programmed cell death in peripheral blood lymphocytes following exposure to CD95 (APO-1/Fas), which is a member of the death receptor family, a subfamily of the TNF-R superfamily. Crosslinking of CD95 with its natural ligand CD95L (CD178) or with agonistic antibodies such as anti-APO-1 induces apoptosis in sensitive cells.		hp.json		http://purl.obolibrary.org/obo/HP_0033278		
GO:1903976	biolink:BiologicalProcess	negative regulation of glial cell migration	Any process that stops, prevents or reduces the frequency, rate or extent of glial cell migration.		hp.json	downregulation of glial cell migration|negative regulation of glia cell migration|down-regulation of glia cell migration|down regulation of glia cell migration|down regulation of glial cell migration|inhibition of glial cell migration|down-regulation of glial cell migration|inhibition of glia cell migration|downregulation of glia cell migration	http://purl.obolibrary.org/obo/GO_1903976		
GO:1903975	biolink:BiologicalProcess	regulation of glial cell migration	Any process that modulates the frequency, rate or extent of glial cell migration.		hp.json	regulation of glia cell migration	http://purl.obolibrary.org/obo/GO_1903975		
HP:0033275	biolink:PhenotypicFeature	Glomerular endothelial tubuloreticular inclusion	Inter-anastomosing tubular structures located within cisternae of endoplasmic reticulum, most often within endothelial cells and associated with exposure to interferon.		hp.json		http://purl.obolibrary.org/obo/HP_0033275		
HP:0033274	biolink:PhenotypicFeature	Glomerular endotheliosis	Enlargement of glomerular endothelial cells by cytoplasmic swelling with resulting partial or complete occlusion of the lumen.		hp.json		http://purl.obolibrary.org/obo/HP_0033274		
HP:0033277	biolink:PhenotypicFeature	Glomerular fibrinoid necrosis	Fibrin associated with glomerular basement membrane disruption and/or lysis of the mesangial matrix; this lesion does not require the presence of karyorrhexis.		hp.json		http://purl.obolibrary.org/obo/HP_0033277		
HP:0033276	biolink:PhenotypicFeature	obsolete Glomerular endocapillary hypercellularity			hp.json		http://purl.obolibrary.org/obo/HP_0033276		
HP:0008480	biolink:PhenotypicFeature	Cervical spondylosis	The presence of arthrosis, i.e., of degenerative joint disease, affecting the cervical vertebral column.	UMLS:C1384641|SNOMEDCT_US:387800004|MSH:D055009|SNOMEDCT_US:387801000|UMLS:C0263854	hp.json	Neck arthritis|Cervical osteoarthritis|Cervical spine degeneration	http://purl.obolibrary.org/obo/HP_0008480		
HP:0008482	biolink:PhenotypicFeature	Asymmetry of spinal facet joints		UMLS:C4024669	hp.json		http://purl.obolibrary.org/obo/HP_0008482		
UBERON:0001668	biolink:AnatomicalEntity	cerebellar vein	A vein that drains the cerebellum.	UMLS:C0226601|MA:0002093|FMA:51227|EMAPA:37139|NCIT:C53032	hp.json	cerebellum vein|vein of cerebellum|vein of epencephalon-1|epencephalon-1 vein	http://purl.obolibrary.org/obo/UBERON_0001668		
UBERON:0001667	biolink:AnatomicalEntity	tibialis posterior	The Tibialis posterior is the most central of all the leg muscles, and is located in the posterior compartment of the leg. It is the key stabilizing muscle of the lower leg. [WP,unvetted].	MA:0002394|FMA:51099|EMAPA:36255|UMLS:C1711425|BTO:0000867|NCIT:C53078	hp.json	musculus tibialis posterior|ibialis posticus|posterior tibialis|tibialis posterior muscle|tibialis caudalis	http://purl.obolibrary.org/obo/UBERON_0001667		uberon_slim
CHEBI:26666	biolink:ChemicalSubstance	short-chain fatty acid	An aliphatic monocarboxylic acid with a chain length of less than C6. If any non-hydrocarbon substituent is present, the compound is not normally regarded as a short-chain fatty acid.	PMID:16633129|PMID:18203540|PMID:20148677|PMID:16870803	hp.json	SCFA|SCFAs|short-chain fatty acids	http://purl.obolibrary.org/obo/CHEBI_26666		3_STAR
CHEBI:26667	biolink:ChemicalSubstance	sialic acid	Any of the N-acylneuraminic acids and their esters and other derivatives of the alcoholic hydroxy groups.	Wikipedia:Sialic_acid	hp.json	acides sialique|Sialsaeuren|Sialsaeure|sialic acids|acide sialique	http://purl.obolibrary.org/obo/CHEBI_26667		3_STAR
HP:0033444	biolink:PhenotypicFeature	Elevated circulating dodecanoylcarnitine concentration	Increased concentration of dodecanoylcarnitine in the blood circulation.		hp.json	Elevated circulating O-dodecanoylcarnitine concentration|Elevated plasma dodecanoylcarnitine, C12:0	http://purl.obolibrary.org/obo/HP_0033444		
HP:0033443	biolink:PhenotypicFeature	Elevated circulating propionylcarnitine concentration	Increased concentration of propionylcarnitine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033443		
HP:0033446	biolink:PhenotypicFeature	Elevated circulating butyrylcarnitine concentration	Increased concentration of O-butyrylcarnitine in the blood circulation.		hp.json	Elevated circulating O-butyrylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0033446		
HP:0033445	biolink:PhenotypicFeature	Reduced circulating acylcarnitine concentration	An abnormally reduced concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine.		hp.json		http://purl.obolibrary.org/obo/HP_0033445		
HP:0033440	biolink:PhenotypicFeature	Elevated circulating octenoylcarnitine concentration	Increased concentration of octenoylcarnitine in the blood circulation.		hp.json	Elevated circulating O-octenoylcarnitine concentration|Elevated plasma octenoylcarnitine, C8:1	http://purl.obolibrary.org/obo/HP_0033440		
HP:0033442	biolink:PhenotypicFeature	Elevated circulating glutarylcarnitine concentration	Increased concentration of glutarylcarnitine in the blood circulation.		hp.json	Elevated circulating O-glutarylcarnitine concentration|Elevated plasma glutarylcarnitine, C5-DC	http://purl.obolibrary.org/obo/HP_0033442		
HP:0033441	biolink:PhenotypicFeature	Elevated circulating hexanoylcarnitine concentration	Increased concentration of hexanoylcarnitine in the blood circulation.		hp.json	Elevated circulating O-hexanoylcarnitine concentration|Elevated plasma hexanoylcarnitine, C6:0	http://purl.obolibrary.org/obo/HP_0033441		
NCBITaxon:2759	biolink:OrganismalEntity	Eukaryota		PMID:30257078|PMID:23020233|GC_ID:1	hp.json	Eucaryotae|eukaryotes|euk-|Eucarya|eukaryotes|Eukaryotae|Eukarya|eucaryotes	http://purl.obolibrary.org/obo/NCBITaxon_2759		
UBERON:0013646	biolink:AnatomicalEntity	buccal nerve	The buccal nerve (also called the long buccal nerve) is a nerve in the face. It is a branch of the mandibular nerve (which is itself a branch of the trigeminal nerve) and transmits sensory information from skin over the buccal membrane (in general, the cheek) and from the second and third molar teeth.	BAMS:bucn|FMA:53066	hp.json	buccinator branch|buccinator nerve|long buccal nerve|long buccal nerve	http://purl.obolibrary.org/obo/UBERON_0013646		
HP:0033448	biolink:PhenotypicFeature	Increased mid-arm muscle circumference	Elevation of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children.		hp.json		http://purl.obolibrary.org/obo/HP_0033448		
HP:0033447	biolink:PhenotypicFeature	Elevated circulating isovalerylcarnitine concentration	Increased concentration of O-isovalerylcarnitine in the blood circulation.		hp.json	Elevated circulating O-isovalerylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0033447		
UBERON:0013647	biolink:AnatomicalEntity	lateral pterygoid nerve	A nerve that innervates the lateral pterygoid muscle.	FMA:53107	hp.json	nervus pterygoideus lateralis|external pterygoid nerve|branch of buccal nerve to lateral pterygoid|nerve to lateral pterygoid	http://purl.obolibrary.org/obo/UBERON_0013647		
UBERON:0013648	biolink:AnatomicalEntity	masseteric artery	The masseteric artery is small and passes laterally through the mandibular notch to the deep surface of the masseter muscle, which it supplies. It anastomoses with the masseteric branches of the external maxillary artery and with the transverse facial artery.	FMA:49739|NCIT:C53052|UMLS:C0226149	hp.json	arteria masseterica	http://purl.obolibrary.org/obo/UBERON_0013648		human_reference_atlas
HP:0033449	biolink:PhenotypicFeature	Decreased mid-arm muscle circumference	Reduction of the midupper arm circumference midway between the acromion and olecranon processes of the ulna with the use of a steel or fiberglass tape. This measure is a proxy for the muscle mass of the upper arm and can be used as a part of the assessment of nutritional status in children.		hp.json		http://purl.obolibrary.org/obo/HP_0033449		
NCBITaxon:10090	biolink:OrganismalEntity	Mus musculus		GC_ID:1	hp.json	mouse|house mouse	http://purl.obolibrary.org/obo/NCBITaxon_10090		
UBERON:0013649	biolink:AnatomicalEntity	fused tarsal bones 1 and 2	A tarsal bone that is formed from the fusion of the 1st and 2nd tarsal bones.		hp.json	fused tarsals 1 and 2|os cuneiforme mediointermedium|os tarsale I et II|tarsals 1+2	http://purl.obolibrary.org/obo/UBERON_0013649		
UBERON:0001675	biolink:AnatomicalEntity	trigeminal ganglion	The cranial ganglion that is associated with and extends fibers into the trigeminal nerve.	BTO:0001231|EHDAA2:0002085|VHOG:0000694|MA:0001080|EFO:0000903|EMAPA:16797|FMA:52618|NCIT:C62642|MESH:D012668|AAO:0011107|MAT:0000511|UMLS:C0040995|EHDAA:2113|ZFA:0000295|BAMS:5Gn|SCTID:244449009|Wikipedia:Trigeminal_ganglion|TAO:0000295|XAO:0000428|GAID:725|XAO:0000427|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1402|BAMS:GV	hp.json	trigeminus ganglion|ganglion trigeminale|Gasserian ganglia|ganglion of trigeminal complex|ganglion of trigeminal complex|ganglion of trigeminal nerve|fifth ganglion|ganglion semilunare|ganglion trigeminale|5th ganglion|ganglion semilunare|semilunar ganglion|ganglion trigeminale|gV|Gasserian ganglion|fused trigeminal ganglion|Gasserian ganglion|trigeminal ganglia|Gasser's ganglion|trigeminal V ganglion|Gasserian ganglia	http://purl.obolibrary.org/obo/UBERON_0001675		uberon_slim|vertebrate_core|pheno_slim|efo_slim
HP:0008477	biolink:PhenotypicFeature	Poorly ossified cervical vertebrae	Decreased ossification of the cervical vertebral bodies, i.e., of the Cervical vertebrae set.	UMLS:C4024670	hp.json		http://purl.obolibrary.org/obo/HP_0008477		
HP:0008476	biolink:PhenotypicFeature	Irregular sclerotic endplates		UMLS:C1868554	hp.json	irregular, dense end plate	http://purl.obolibrary.org/obo/HP_0008476		
UBERON:0001674	biolink:AnatomicalEntity	masseteric vein	A plexiform vein accompanying the masseteric artery that empty into the pterygoid venous plexus.	FMA:52519|UMLS:C0925179|MA:0002167|EMAPA:37168|NCIT:C53051	hp.json	masseteric veins	http://purl.obolibrary.org/obo/UBERON_0001674		
UBERON:0001677	biolink:AnatomicalEntity	sphenoid bone	An unpaired bone situated at the base of the skull in front of the temporal bone and basilar part of the occipital bone. The sphenoid bone is one of the seven bones that articulate to form the orbit. Its shape somewhat resembles that of a butterfly or bat with its wings extended.	NCIT:C12790|UMLS:C0037884|CALOHA:TS-2343|FMA:52736|GAID:230|OpenCyc:Mx4rwAU9XpwpEbGdrcN5Y29ycA|MA:0001472|EMAPA:18340|MESH:D013100	hp.json	sphenoid|os sphenoidale|sphenoidal bone|sphenoid complex|os sphenoidum|os sphenoidale|os sphenoidale|butterfly bone	http://purl.obolibrary.org/obo/UBERON_0001677		uberon_slim|pheno_slim
HP:0008479	biolink:PhenotypicFeature	Hypoplastic vertebral bodies		UMLS:C1863353	hp.json	Small vertebrae|Underdeveloped back bones|Small vertebral bodies	http://purl.obolibrary.org/obo/HP_0008479		
UBERON:0001676	biolink:AnatomicalEntity	occipital bone	The bone at the lower, posterior part of the skull.	GAID:227|NCIT:C12757|EMAPA:25112|MA:0001468|SCTID:181796003|FMA:52735|OpenCyc:Mx4rwQtsiZwpEbGdrcN5Y29ycA|UMLS:C0028784|Wikipedia:Occipital_bone|MESH:D009777	hp.json	occipital squama|os occipitale|occipital complex|os occipitale|occipital complex	http://purl.obolibrary.org/obo/UBERON_0001676		uberon_slim|pheno_slim
HP:0008478	biolink:PhenotypicFeature	Scheuermann-like vertebral changes		UMLS:C1844926	hp.json		http://purl.obolibrary.org/obo/HP_0008478		
HP:0008473	biolink:PhenotypicFeature	Narrow anterio-posterior vertebral body diameter	An abnormal reduction of the anterioposterior diameter of the vertebral body.	UMLS:C4021540	hp.json	Reduced sagittal diameter of vertebrae|Reduced anterior-posterior diameter of vertebral bodies	http://purl.obolibrary.org/obo/HP_0008473		
HP:0008472	biolink:PhenotypicFeature	Prominent protruding coccyx		UMLS:C4280412|UMLS:C1850044	hp.json	Prominent protruding tailbone|Large tailbone	http://purl.obolibrary.org/obo/HP_0008472		
HP:0008475	biolink:PhenotypicFeature	Hypoplastic sacral vertebrae		UMLS:C2751479	hp.json		http://purl.obolibrary.org/obo/HP_0008475		
HP:0008491	biolink:PhenotypicFeature	Premature anterior fontanel closure	Early closure (ossification) of the anterior fontanelle, which generally undergoes closure around the 18th month of life.	UMLS:C4024668	hp.json		http://purl.obolibrary.org/obo/HP_0008491		
CHEBI:75603	biolink:ChemicalSubstance	EC 6.* (ligase) inhibitor	Any enzyme inhibitor that interferes with the action of a ligase (EC 6.*.*.*). Ligases are enzymes that catalyse the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.	Wikipedia:Ligase	hp.json	ligase inhibitor|EC 6.*.*.* inhibitor|EC 6.* (ligase) inhibitors|EC 6.*.*.* inhibitors|ligase inhibitors|EC 6.* inhibitor|EC 6.* inhibitors	http://purl.obolibrary.org/obo/CHEBI_75603		3_STAR
HP:0008490	biolink:PhenotypicFeature	Sacral segmentation defect		UMLS:C1850329	hp.json		http://purl.obolibrary.org/obo/HP_0008490		
CHEBI:75600	biolink:ChemicalSubstance	EC 6.3.* (C-N bond-forming ligase) inhibitor	A ligase inhibitor that interferes with the action of a C-N bond-forming ligase (EC 6.3.*.*).		hp.json	C-N bond-forming ligase (EC 6.3.*) inhibitors|EC 6.3.* inhibitors|C-N bond-forming ligase inhibitor|C-N bond-forming ligase inhibitors|EC 6.3.* inhibitor|C-N bond-forming ligase (EC 6.3.*) inhibitor|EC 6.3.* (C-N bond-forming ligase) inhibitorS|EC 6.3.*.* inhibitor|C--N bond-forming ligase inhibitor|C--N bond-forming ligase inhibitors|EC 6.3.*.* inhibitors	http://purl.obolibrary.org/obo/CHEBI_75600		3_STAR
CHEBI:75604	biolink:ChemicalSubstance	EC 6.4.* (C-C bond-forming ligase) inhibitor	A ligase inhibitor that interferes with the action of a C-C bond-forming ligase (EC 6.4.*.*).		hp.json	C-C bond-forming ligase inhibitor|EC 6.4.*.* inhibitors|C-C bond-forming ligase (EC 6.4.*) inhibitor|C--C bond-forming ligase inhibitors|EC 6.4.* inhibitors|EC 6.4.* (C-C bond-forming ligase) inhibitorS|EC 6.4.* inhibitor|C--C bond-forming ligase inhibitor|C-C bond-forming ligase (EC 6.4.*) inhibitorS|EC 6.4.*.* inhibitor|C-C bond-forming ligase inhibitors	http://purl.obolibrary.org/obo/CHEBI_75604		3_STAR
HP:0033455	biolink:PhenotypicFeature	Elevated urinary dicarboxylic acid level	Increased amount of a dicarboxylic acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033455		
HP:0033454	biolink:PhenotypicFeature	Tube feeding	Feeding problem necessitating food and nutrient delivery via a tube.		hp.json		http://purl.obolibrary.org/obo/HP_0033454		
HP:0033457	biolink:PhenotypicFeature	Elevated urine 3-methyl-2-oxovaleric acid level	Increased amount of 3-methyl-2-oxovaleric acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033457		
HP:0033456	biolink:PhenotypicFeature	Elevated urine keto acid level	Increased amount of a keta acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033456		
HP:0033451	biolink:PhenotypicFeature	Increased circulating prealbumin concentration	An elevation above the normal concentration of prealbumin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033451		
HP:0033450	biolink:PhenotypicFeature	Abnormal circulating prealbumin concentration	Any deviation from normal concentration of albumin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033450		
HP:0033453	biolink:PhenotypicFeature	Limited neck extension	Reduced abilty to move the head back towards the ceiling so that one is looking upwards.		hp.json		http://purl.obolibrary.org/obo/HP_0033453		
HP:0033452	biolink:PhenotypicFeature	Decreased circulating prealbumin concentration	A reduction from the normal concentration of prealbumin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033452		
HP:0033459	biolink:PhenotypicFeature	Decreased circulating apolipoprotein concentration	Reduced concentration in the blood circulation of a lipid-transport protein (apoliprotein).		hp.json	Decreased apolipoprotein level	http://purl.obolibrary.org/obo/HP_0033459		
HP:0033458	biolink:PhenotypicFeature	Elevated urine 4-methyl-2-oxopentanoic acid level	Increased amount of 4-methyl-2-oxopentanoic acid in the urine.		hp.json	Increased urine alpha-ketoisocaproic acid level	http://purl.obolibrary.org/obo/HP_0033458		
UBERON:0013636	biolink:AnatomicalEntity	epithelium of intestinal villus	An epithelium that is part of a intestinal villus.	FMA:63587	hp.json	villous epithelium|intestinal villus epithelium|villus epithelium	http://purl.obolibrary.org/obo/UBERON_0013636		
UBERON:0013637	biolink:AnatomicalEntity	prostate gland lateral lobe	The prostate gland lobe that is located on the lateral side of the organ.	EMAPA:29822|NCIT:C13092|FMA:19577|MA:0003125	hp.json	lateral ventral lobe of prostate gland|lateral prostate|lateral lobe of prostate gland|lateral lobe of prostate	http://purl.obolibrary.org/obo/UBERON_0013637		
HP:0008488	biolink:PhenotypicFeature	Anterior rounding of vertebral bodies		UMLS:C1850043	hp.json		http://purl.obolibrary.org/obo/HP_0008488		
UBERON:0001663	biolink:AnatomicalEntity	cerebral vein	The cerebral veins are divisible into external and internal groups according to the outer surfaces or the inner parts of the hemispheres they drain into. The external veins are the superior cerebral veins, inferior cerebral veins, and middle cerebral vein. [WP,unvetted].	Wikipedia:Cerebral_veins|XAO:0004160|EMAPA:37140|GAID:530|NCIT:C53037|SCTID:244392000|UMLS:C0007797|FMA:50981|MESH:D002550|MA:0002096	hp.json	venae cerebri|venae cerebri|venae encephali|venae encephali	http://purl.obolibrary.org/obo/UBERON_0001663		pheno_slim
HP:0008489	biolink:PhenotypicFeature	Spondylolisthesis at L5-S1	Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the fifth lumbar vertebral body (L5) onto the sacrum (level S1).	UMLS:C3275799	hp.json	Spondylolysis and spondylolisthesis of l5	http://purl.obolibrary.org/obo/HP_0008489		
UBERON:0001665	biolink:AnatomicalEntity	triceps surae	The triceps surae is a pair of muscles located at the calf - the gastrocnemius and the soleus. These muscles both insert into the calcaneus, the bone of the heel of the human foot, and form the major part of the muscle of the back part of the lower leg, commonly known as the calf muscle. The triceps surae is connected to the foot through the Achilles tendon, and has 3 heads deriving from the 2 major masses of muscle. The superficial portion (the gastrocnemius) gives off 2 heads attaching to the base of the femur directly above the knee. The deep (profundis) mass of muscle (the soleus) forms the remaining head which attaches to the superior posterior area of the tibia. The triceps surae is innervated by the tibial nerve, specifically, nerve roots L5-S2. [WP,unvetted].	NCIT:C53181|FMA:51062|EMAPA:36267|MA:0002400|UMLS:C0224458	hp.json	sural triceps|gastrosoleus complex|gastrosoleus|calf muscle|musculus triceps surae	http://purl.obolibrary.org/obo/UBERON_0001665		uberon_slim
HP:0008484	biolink:PhenotypicFeature	Thoracolumbar interpediculate narrowness	A reduction of the distance between thoracolumbar vertebral pedicles.	UMLS:C1864364	hp.json	Narrow thoracolumbar interpediculate distance	http://purl.obolibrary.org/obo/HP_0008484		
HP:0008483	biolink:PhenotypicFeature	Cervical vertebral bodies with decreased anteroposterior diameter		UMLS:C1847393	hp.json		http://purl.obolibrary.org/obo/HP_0008483		
HP:0008486	biolink:PhenotypicFeature	Lumbar interpedicular narrowing	Narrowing (becoming gradually narrower) of the distance between lumbar vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column.	UMLS:C1849079	hp.json	Decreasing lumbar vertebrae interpediculate distance	http://purl.obolibrary.org/obo/HP_0008486		
UBERON:0001649	biolink:AnatomicalEntity	glossopharyngeal nerve	Cranial nerve that branches into the ramus communicans (to the skin), the pretrematic (to the walls of the pharynx and mouth, viscero-sensory fibers), and the larval post-trematic branch (lost in the adult).	Wikipedia:Glossopharyngeal_nerve|BAMS:IXn|BTO:0004979|BIRNLEX:899|BAMS:9n|GAID:827|MESH:D005930|VHOG:0000701|AAO:0010474|EHDAA2:0000709|FMA:50870|XAO:0003096|OpenCyc:Mx4rwIr5X5wpEbGdrcN5Y29ycA|MA:0001093|SCTID:362465002|ZFA:0000668|MBA:808|UMLS:C0017679|UMLS:C0017679|TAO:0000668|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=701|HBA:9334|EMAPA:17268|NCIT:C12723|EHDAA:3733|UMLS:C1305752	hp.json	CN-IX|nervus glossopharyngeus|ninth cranial nerve|nervus glossopharyngeus|glossopharyngeal nerve tree|cranial nerve IX|nerve IX|nervus glossopharyngeus|9n|nervus glossopharyngeus [ix]|glossopharyngeal IX|glossopharyngeal nerve [IX]|glossopharyngeal IX nerve	http://purl.obolibrary.org/obo/UBERON_0001649		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
HP:0033460	biolink:PhenotypicFeature	Increased circulating apolipoprotein circulation	Elevated concentration in the blood circulation of a lipid-transport protein (apoliprotein).		hp.json		http://purl.obolibrary.org/obo/HP_0033460		
HP:0008460	biolink:PhenotypicFeature	Hypoplastic spinal processes		UMLS:C4024674	hp.json	Underdeveloped spinal processes	http://purl.obolibrary.org/obo/HP_0008460		
UBERON:0001646	biolink:AnatomicalEntity	abducens nerve	Cranial nerve that runs to the eye muscles.	BIRNLEX:876|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=550|MBA:710|MA:0001087|OpenCyc:Mx4rvjl41ZwpEbGdrcN5Y29ycA|BAMS:VIn|MESH:D000010|GAID:824|UMLS:C0000741|VHOG:0000697|AAO:0010471|XAO:0003093|UMLS:C0000741|BM:Pons-VIN|EMAPA:18216|HBA:9325|FMA:50867|ZFA:0000310|EHDAA2:0000103|NCIT:C12665|TAO:0000310	hp.json	abducent nerve [VI]|abducens nerve tree|nervus abducens [VI]|6n|sixth cranial nerve|lateral rectus nerve|abducens VI nerve|nerve VI|nervus abducens|abducents VI nerve|nervus abducens|CN-VI|abducent nerve|abducens nerve/root|cranial nerve VI|abducens nerve [VI]	http://purl.obolibrary.org/obo/UBERON_0001646		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0001645	biolink:AnatomicalEntity	trigeminal nerve	Cranial nerve that has three branches - the ophthalmic (supplying the skin of the nose and upper jaw), the maxillary and the mandibular (supplying the lower jaw).	EFO:0001402|BM:VN|GAID:726|UMLS:C0040996|MESH:D014276|NCIT:C12806|AAO:0010470|XAO:0003092|Wikipedia:Trigeminal_nerve|EHDAA:3738|EHDAA2:0002084|OpenCyc:Mx4rwMF8CJwpEbGdrcN5Y29ycA|UMLS:C0040996|ZFA:0000697|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=549|EMAPA:17576|BAMS:5n|SCTID:362459002|HBA:9322|BAMS:Vn|BIRNLEX:869|FMA:50866|BTO:0001072|BAMS:nV|MBA:901|TAO:0000697|MFMO:0000093|VHOG:0000704|MA:0001100	hp.json	trigeminal V|nervus trigeminus [v]|fifth cranial nerve|trigeminus|trigeminal v nerve|5n|cranial nerve V|nervus trigeminus|nerve V|trigeminal nerve [V]|trigeminal nerve tree|CN-V|nervus trigeminus|nervus trigeminus	http://purl.obolibrary.org/obo/UBERON_0001645		pheno_slim|human_reference_atlas|efo_slim|uberon_slim|vertebrate_core
UBERON:0001648	biolink:AnatomicalEntity	vestibulocochlear nerve	Cranial nerve that transmits sound and equilibrium (balance) information from the inner ear to the brain.	OpenCyc:Mx4rvVjMFZwpEbGdrcN5Y29ycA|GAID:839|AAO:0010473|BAMS:VIIIn|XAO:0003095|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=553|UMLS:C0001162|EMAPA:17801|MA:0001109|UMLS:C0001162|VHOG:0000695|EHDAA2:0002194|BIRNLEX:890|FMA:50869|ZFA:0000247|UMLS:C1278835|TAO:0000247|NCIT:C12996|BAMS:nVIII|MESH:D000159|BAMS:8n|BTO:0003490|MBA:933|HBA:9331	hp.json	nervus octavus|eighth cranial nerve|vestibulocochlear nerve [VIII]|nervus vestibulocochlearis [viii]|acoustic VIII nerve|vestibulocochlear nerve tree|acoustic nerve (Crosby)|VIIIth cranial nerve|nervus statoacusticus|octaval nerve|CN-VIII|statoacoustic nerve|vestibulocochlear VIII nerve|cranial nerve VIII|cochleovestibular nerve|nervus vestibulocochlearis|acoustic nerve|stato-acoustic nerve|8n|cochlear-vestibular nerve|VIII nerve	http://purl.obolibrary.org/obo/UBERON_0001648		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0001647	biolink:AnatomicalEntity	facial nerve	Cranial nerve that branches into the supraorbital (supplying the skin of the eye region and the lateral line organs here), the palatine (to the roof of the buccal cavity), and the hyomandibular (dividing into the jugular and mental branches).	UMLS:C0015462|GAID:719|OpenCyc:Mx4rvthgEpwpEbGdrcN5Y29ycA|MBA:798|UMLS:C0015462|AAO:0010472|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=551|XAO:0003094|EHDAA:3729|HBA:9328|MESH:D005154|BM:Pons-VIIN|MA:0001091|NCIT:C12714|BIRNLEX:827|FMA:50868|ZFA:0000664|EMAPA:17796|VHOG:0000706|BAMS:nVII|BAMS:VIIn|BAMS:Viin|BAMS:7n|TAO:0000664|EHDAA2:0000489	hp.json	nerve VII|facial nerve tree|nervus facialis [vii]|facial VII|face nerve|facial nerve [VII]|nervus facialis|cranial nerve VII|seventh cranial nerve|nerve of face|nervus facialis|7n|CN-VII|facial nerve or its root|branchiomeric cranial nerve|facial nerve/root|facial VII nerve	http://purl.obolibrary.org/obo/UBERON_0001647		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0013631	biolink:AnatomicalEntity	sesamoid element	Ossicle that develops within bands of dense, regular connective tissue (e.g., tendons and ligaments). Sesamoids are generally located proximate to a bony prominence, over which the dense regular connective tissue wraps, and/or a joint or articulation.	VSAO:0000137	hp.json	sesamoid	http://purl.obolibrary.org/obo/UBERON_0013631		
HP:0033466	biolink:PhenotypicFeature	Weak grip	Reduced grip strength. Gripping is the motion by which the hand tightly grasps an object or other hand.		hp.json		http://purl.obolibrary.org/obo/HP_0033466		
UBERON:0013632	biolink:AnatomicalEntity	sesamoid cartilage	A sesamoid element that is composed primarily of cartilage tissue.	FMA:55379	hp.json	sesamoid cartilage of cricopharyngeal ligament|cartilago sesamoidea	http://purl.obolibrary.org/obo/UBERON_0013632		
HP:0033465	biolink:PhenotypicFeature	Elevated circulating tetradecanoylcarnitine concentration	Elevated circulating tetradecanoyl concentration.		hp.json	Elevated circulating C14 carnitine concentration|Elevated circulating myristoylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0033465		
HP:0033468	biolink:PhenotypicFeature	10-minute APGAR score of 0			hp.json		http://purl.obolibrary.org/obo/HP_0033468		
HP:0033467	biolink:PhenotypicFeature	Low 10-minute APGAR score	A normal APGAR score can be coded as 'not Low 10-minute APGAR score'.		hp.json		http://purl.obolibrary.org/obo/HP_0033467		
HP:0033462	biolink:PhenotypicFeature	Elevated circulating oleylcarnitine concentration	Increased concentration of oleylcarnitine in the blood circulation.		hp.json	Elevated plasma oleylcarnitine, C18:1	http://purl.obolibrary.org/obo/HP_0033462		
HP:0033461	biolink:PhenotypicFeature	Elevated circulating 3-hydroxylinoleylcarnitine concentration	Increased concentration of 3-hydroxylinoleylcarnitine in the blood circulation.		hp.json	Elevated plasma 3-OH-Linoleylcarnitine, C18:1-OH	http://purl.obolibrary.org/obo/HP_0033461		
HP:0033464	biolink:PhenotypicFeature	Elevated circulating 3-hydroxypalmitoleylcarnitine concentration	Increased concentration of 3-hydroxypalmitoleylcarnitine in the blood circulation.		hp.json	Elevated plasma 3-OH-Palmitoleylcarnitine, C16:1-OH|Elevated circulating 3-OH-palmitoleylcarnitine concentration	http://purl.obolibrary.org/obo/HP_0033464		
CL:1001568	biolink:Cell	pulmonary artery endothelial cell		BTO:0001141	hp.json	PAEC cell	http://purl.obolibrary.org/obo/CL_1001568		
UBERON:0013630	biolink:AnatomicalEntity	short bone	Short bones are designated as those bones that are as wide as they are long. Their primary function is to provide support and stability with little to no movement. They are one of five types of bones: long, short, flat, irregular and sesamoid. Examples of these bones include the tarsals in the foot and the carpals in the hand.	NCIT:C33545|FMA:7475	hp.json		http://purl.obolibrary.org/obo/UBERON_0013630		
CL:1001567	biolink:Cell	lung endothelial cell			hp.json	endothelial cell of lung|pulmonary vessel endothelial cell	http://purl.obolibrary.org/obo/CL_1001567		
HP:0033463	biolink:PhenotypicFeature	obsolete Elevated circulating palmitoleylcarnitine concentration			hp.json		http://purl.obolibrary.org/obo/HP_0033463		
HP:0008459	biolink:PhenotypicFeature	Cervical vertebral agenesis	Agenesis of one or more vertebrae of the cervical vertebral column.	SNOMEDCT_US:91880006|MSH:C562952|UMLS:C0432160	hp.json	Missing cervical vertebrae|Cervical vertebrae agenesis	http://purl.obolibrary.org/obo/HP_0008459		
HP:0033469	biolink:PhenotypicFeature	10-minute APGAR score of 1			hp.json		http://purl.obolibrary.org/obo/HP_0033469		
HP:0008458	biolink:PhenotypicFeature	Progressive congenital scoliosis	A progressive form of scoliosis with congenital onset.	UMLS:C1857025	hp.json		http://purl.obolibrary.org/obo/HP_0008458		
UBERON:0001653	biolink:AnatomicalEntity	facial vein	The anterior facial vein (facial vein) commences at the side of the root of the nose, and is a direct continuation of the angular vein where it also receives a small nasal branch. It lies behind the facial artery and follows a less tortuous course. It receives blood from the external palatine vein before it either joins the anterior branch of the retromandibular vein to form the common facial vein, or drains directly into the internal jugular vein. [WP,unvetted].	SCTID:181374006|Wikipedia:Facial_vein|UMLS:C0226532|NCIT:C32579|OpenCyc:Mx4rvziz3JwpEbGdrcN5Y29ycA|MA:0002115|AAO:0010513|FMA:50874|EMAPA:19220	hp.json	face vein|anterior facial vein|vena facialis anterior|anterior facial vein|vena facialis anterior|vein of face	http://purl.obolibrary.org/obo/UBERON_0001653		human_reference_atlas|uberon_slim
HP:0008455	biolink:PhenotypicFeature	Dysplastic sacrum	A developmental defect of the sacrum characterized by partial or disordered development of the sacrum in which portions of the sacrum, which normally is formed by fusion of five sacral vertebrae S1-S5, fail to form or fail to form normally.	UMLS:C1851305	hp.json	Sacral dysgenesis|Partial sacral agenesis|Absence of some of the sacral and coccygeal bones	http://purl.obolibrary.org/obo/HP_0008455		
UBERON:0001652	biolink:AnatomicalEntity	left pulmonary artery	The pulmonary artery that supplies the left lung.	galen:LeftPulmonaryArtery|UMLS:C0923925|EMAPA:37097|NCIT:C32971|Wikipedia:Left_pulmonary_artery|FMA:50873|SCTID:244234004|MA:0002032	hp.json	arteria pulmonalis sinistra|left pulmonary arterial tree|left main pulmonary artery|arteria pulmonalis sinistra	http://purl.obolibrary.org/obo/UBERON_0001652		human_reference_atlas|uberon_slim
HP:0008454	biolink:PhenotypicFeature	Lumbar kyphosis	Over curvature of the lumbar region.	UMLS:C1844818	hp.json	Rounded lower back|Lumbar gibbus deformity	http://purl.obolibrary.org/obo/HP_0008454		
HP:0008457	biolink:PhenotypicFeature	Caudal interpedicular narrowing	Narrowing (becoming gradually narrower) of the distance between vertebral pedicles that gets progressively more severe towards to caudal (lower) end of the vertebral column. Note that normally, the interpedicular distances get progressively wider as one proceeds down the spine.	UMLS:C1863734	hp.json	Caudal narrowing of interpedicular distances	http://purl.obolibrary.org/obo/HP_0008457		
HP:0008456	biolink:PhenotypicFeature	C2-C3 subluxation	A partial dislocation of the intervertebral joint between the second and third cervical vertebrae.	UMLS:C2678323	hp.json		http://purl.obolibrary.org/obo/HP_0008456		
HP:0008451	biolink:PhenotypicFeature	Posterior vertebral hypoplasia		UMLS:C1856780	hp.json		http://purl.obolibrary.org/obo/HP_0008451		
HP:0008450	biolink:PhenotypicFeature	Narrow vertebral interpedicular distance	A reduction of the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces.	UMLS:C1832598	hp.json	Narrow interpedicular space|Interpedicular narrowing|Narrowing of interpediculate distances|Narrow interpediculate distances	http://purl.obolibrary.org/obo/HP_0008450		hposlim_core
UBERON:0001651	biolink:AnatomicalEntity	right pulmonary artery	The pulmonary artery that supplies the right lung.	galen:RightPulmonaryArtery|UMLS:C0923924|MA:0002500|NCIT:C33489|Wikipedia:Right_pulmonary_artery|FMA:50872|EMAPA:37378|SCTID:244235003	hp.json	arteria pulmonalis dextra|arteria pulmonalis dextra|right main pulmonary artery|right pulmonary arterial tree	http://purl.obolibrary.org/obo/UBERON_0001651		human_reference_atlas|uberon_slim
HP:0008453	biolink:PhenotypicFeature	Congenital kyphoscoliosis		SNOMEDCT_US:405772002|UMLS:C0345392	hp.json		http://purl.obolibrary.org/obo/HP_0008453		
UBERON:0001650	biolink:AnatomicalEntity	hypoglossal nerve	Cranial nerve that innervates the muscles of the tongue.	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=704|MA:0001094|EHDAA:2859|MESH:D007002|BTO:0003386|VHOG:0000693|EMAPA:17269|BAMS:nXII|XAO:0004215|SCTID:362471008|EHDAA2:0000798|Wikipedia:Hypoglossal_nerve|HBA:9343|MBA:813|UMLS:C0020614|NCIT:C12732|BAMS:XIIn|OpenCyc:Mx4rv9eWA5wpEbGdrcN5Y29ycA|AAO:0010477|GAID:828|UMLS:C0020614|BIRNLEX:820|BAMS:12n|FMA:50871	hp.json	nervus hypoglossus|cranial nerve XII|nervus hypoglossus|nervi hypoglossalis|CN-XII|twelfth cranial nerve|nervus hypoglossus [xii]|hypoglossal XII|nerve XII|hypoglossal nerve tree|hypoglossal nerve [XII]|12n|hypoglossal XII nerve|hypoglossal nerve/ root	http://purl.obolibrary.org/obo/UBERON_0001650		human_reference_atlas|uberon_slim|pheno_slim
HP:0008452	biolink:PhenotypicFeature	Wafer-thin platyspondyly		UMLS:C1865124	hp.json		http://purl.obolibrary.org/obo/HP_0008452		
UBERON:0001639	biolink:AnatomicalEntity	hepatic portal vein	A portal vein that transports nutrients from the digestive tract to the liver[Kardong].	ZFA:0005090|AAO:0010214|TAO:0005090|MA:0002132|VHOG:0000642|FMA:50735	hp.json	portal vein|primary hepatic portal vein|HPV|vena portae hepatis|portal vein of liver|primary hepatic portal veins|hepatic portal tree|liver portal vein	http://purl.obolibrary.org/obo/UBERON_0001639		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
NCBITaxon:10088	biolink:OrganismalEntity	Mus <genus>		GC_ID:1	hp.json	mice|mouse|Mus	http://purl.obolibrary.org/obo/NCBITaxon_10088		
UBERON:0001638	biolink:AnatomicalEntity	vein	Any of the tubular branching vessels that carry blood from the capillaries toward the heart.	SCTID:181367001|OpenCyc:Mx4rvVjkWpwpEbGdrcN5Y29ycA|AEO:0000209|MA:0000067|UMLS:C0042449|MAT:0000037|AAO:0010212|GAID:492|Wikipedia:Vein|MIAA:0000037|BTO:0000234|CALOHA:TS-1108|VHOG:0001743|EHDAA2:0003254|ZFA:0000082|EV:0100031|galen:Vein|TAO:0000082|MESH:D014680|NCIT:C12814|XAO:0000115|EFO:0000816|EMAPA:35906|FMA:50723	hp.json	venous vessel|vena|vascular element|venae|vena|venous tree organ part|venous subtree	http://purl.obolibrary.org/obo/UBERON_0001638		pheno_slim|efo_slim|uberon_slim|vertebrate_core
HP:0033471	biolink:PhenotypicFeature	10-minute APGAR score of 3			hp.json		http://purl.obolibrary.org/obo/HP_0033471		
HP:0008470	biolink:PhenotypicFeature	Lower thoracic interpediculate narrowness	A reduction of the distance between the lower thoracic vertebral pedicles.	UMLS:C1854940	hp.json	Narrowness of interpediculate distances in lower thoracic regions	http://purl.obolibrary.org/obo/HP_0008470		
HP:0033470	biolink:PhenotypicFeature	10-minute APGAR score of 2			hp.json		http://purl.obolibrary.org/obo/HP_0033470		
UBERON:0001635	biolink:AnatomicalEntity	superior cerebellar artery	The superior cerebellar artery (SCA) arises near the termination of the basilar artery. It passes lateralward, immediately below the oculomotor nerve, which separates it from the posterior cerebral artery, winds around the cerebral peduncle, close to the trochlear nerve, and, arriving at the upper surface of the cerebellum, divides into branches which ramify in the pia mater and anastomose with those of the inferior cerebellar arteries. Several branches are given to the pineal body, the anterior medullary velum, and the tela chorioidea of the third ventricle. [WP,unvetted].	FMA:50573|EHDAA2:0000681|EMAPA:19309|MA:0001934|UMLS:C0149575|NCIT:C33669	hp.json	arteria superior cerebelli	http://purl.obolibrary.org/obo/UBERON_0001635		human_reference_atlas|uberon_slim
UBERON:0001637	biolink:AnatomicalEntity	artery	An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition].	Wikipedia:Artery|AEO:0000208|FMA:50720|MESH:D001158|EV:0100026|AAO:0010211|galen:Artery|MA:0000064|EHDAA2:0000143|MAT:0000034|EHDAA2:0003253|NCIT:C12372|BTO:0000573|MIAA:0000034|EMAPA:35147|GAID:468|XAO:0000114|ZFA:0000005|SCTID:362877004|OpenCyc:Mx4rvVjknZwpEbGdrcN5Y29ycA|EFO:0000814|UMLS:C0003842|CALOHA:TS-0054|TAO:0000005|VHOG:0001251	hp.json	arterial vessel|arterial tree organ part|arterial system|arteries|arterial subtree	http://purl.obolibrary.org/obo/UBERON_0001637		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0013620	biolink:AnatomicalEntity	lower primary molar tooth	A primary molar tooth that is part of a lower jaw region.	FMA:84213	hp.json	primary lower molar tooth|lower deciduous molar tooth	http://purl.obolibrary.org/obo/UBERON_0013620		
HP:0033477	biolink:PhenotypicFeature	Abnormal circulating lipoprotein lipase concentration	A deviation from the normal concentration of lipoprotein lipase in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033477		
UBERON:0013621	biolink:AnatomicalEntity	lower secondary molar tooth	A secondary molar tooth that is part of a lower jaw region.	FMA:55721	hp.json	lower permanent molar|lower permanent molar tooth|mandibular secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0013621		
HP:0033476	biolink:PhenotypicFeature	Extractable nuclear antigen positivity	The presence of autoantibodies in the serum that react against extractable nuclear components that are referred to as extractable because they can be extracted from cell nuclei with saline solution.		hp.json		http://purl.obolibrary.org/obo/HP_0033476		
CHEBI:26650	biolink:ChemicalSubstance	serine family amino acid	An L-alpha-amino acid which is biosynthesised from 3-phosphoglycerate (i.e. serine, glycine, cysteine and homocysteine). A closed class.	PMID:20709681	hp.json	serine family amino acids|3-phosphoglycerate family amino acids|3-phosphoglycerate family amino acid	http://purl.obolibrary.org/obo/CHEBI_26650		3_STAR
HP:0033479	biolink:PhenotypicFeature	Abnormal circulating bilirubin concentration			hp.json		http://purl.obolibrary.org/obo/HP_0033479		
HP:0033478	biolink:PhenotypicFeature	Increased circulating lipoprotein lipase concentration	Increased concentration of lipoprotein lipase in the blood circulation.		hp.json	Elevated lipoprotein lipase level	http://purl.obolibrary.org/obo/HP_0033478		
HP:0033473	biolink:PhenotypicFeature	10-minute APGAR score of 5			hp.json		http://purl.obolibrary.org/obo/HP_0033473		
HP:0033472	biolink:PhenotypicFeature	10-minute APGAR score of 4			hp.json		http://purl.obolibrary.org/obo/HP_0033472		
HP:0033475	biolink:PhenotypicFeature	Limited shoulder abduction	Decreased ability to move the arm away from the midline of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0033475		
HP:0033474	biolink:PhenotypicFeature	10-minute APGAR score of 6			hp.json		http://purl.obolibrary.org/obo/HP_0033474		
UBERON:0013617	biolink:AnatomicalEntity	upper primary molar tooth	A primary molar tooth that is part of a upper jaw region.	FMA:84210	hp.json	upper deciduous molar tooth|primary upper molar tooth|upper primary molar tooth|upper deciduous molar	http://purl.obolibrary.org/obo/UBERON_0013617		
UBERON:0013618	biolink:AnatomicalEntity	secondary molar tooth		FMA:84207	hp.json	secondary molar tooth|permanent molar tooth	http://purl.obolibrary.org/obo/UBERON_0013618		pheno_slim
UBERON:0013619	biolink:AnatomicalEntity	upper secondary molar tooth	A secondary molar tooth that is part of a upper jaw region.	FMA:55720	hp.json	upper permanent molar tooth|maxillary secondary molar tooth|upper secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0013619		
CHEBI:38632	biolink:ChemicalSubstance	membrane transport modulator	Any agent that affects the transport of molecular entities across a biological membrane.		hp.json	membrane transport modulators	http://purl.obolibrary.org/obo/CHEBI_38632		3_STAR
HP:0008469	biolink:PhenotypicFeature	Cervical vertebral dysplasia	Dysplasia of the cervical vertebral column.	UMLS:C1861693|MSH:C566140	hp.json		http://purl.obolibrary.org/obo/HP_0008469		
UBERON:0013616	biolink:AnatomicalEntity	primary molar tooth		FMA:84206	hp.json	deciduous molar tooth|primary molar tooth|temporary molar tooth	http://purl.obolibrary.org/obo/UBERON_0013616		pheno_slim
UBERON:0001641	biolink:AnatomicalEntity	transverse sinus	One of the dural venous sinuses and drains the superior sagittal sinus the occipital sinus and the straight sinus, and empties into the sigmoid sinus which in turn reaches the jugular bulb.	MA:0001868|EMAPA:18637|OpenCyc:Mx4rwDb62ZwpEbGdrcN5Y29ycA|FMA:50763|ncithesaurus:Transverse_Sinus	hp.json	transverse sinus|sinus transversus durae matris|transverse sinus vein|groove for right and left transverse sinuses|lateral sinus|sinus transversus	http://purl.obolibrary.org/obo/UBERON_0001641		human_reference_atlas|uberon_slim
HP:0008465	biolink:PhenotypicFeature	Absent vertebra	A developmental defect characterized by agenesis of one or more vertebral bodies.	UMLS:C0158776|SNOMEDCT_US:15843004	hp.json	Absent vertebrae	http://purl.obolibrary.org/obo/HP_0008465		
UBERON:0001644	biolink:AnatomicalEntity	trochlear nerve	A cranial nerve that runs to the eye muscles.	GAID:838|NCIT:C12808|OpenCyc:Mx4rvyeBQ5wpEbGdrcN5Y29ycA|MESH:D014321|BAMS:nIV|HBA:9319|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=466|EMAPA:18218|BM:IVN|BIRNLEX:1654|XAO:0003091|ZFA:0000600|BAMS:4n|MA:0001105|TAO:0000600|UMLS:C0041159|AAO:0010469|VHOG:0000705|FMA:50865|EHDAA2:0002090|BAMS:IVn|MBA:911|UMLS:C0041159	hp.json	CN-IV|trochlear IV nerve|nerve IV|pathetic nerve|trochlear nerve/root|trochlear nerve tree|cranial nerve IV|trochlear|4n|nervus trochlearis|trochlear nerve or its root|nervus trochlearis [IV]|fourth cranial nerve|superior oblique nerve|trochlear nerve [IV]	http://purl.obolibrary.org/obo/UBERON_0001644		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
HP:0008468	biolink:PhenotypicFeature	Abnormal sacral segmentation	An abnormality related to a defect of vertebral separation of sacral vertebrae during development.	UMLS:C1968942	hp.json		http://purl.obolibrary.org/obo/HP_0008468		
UBERON:0001643	biolink:AnatomicalEntity	oculomotor nerve	Cranial nerve which connects the midbrain to the extra-ocular and intra-ocular muscles.	MESH:D009802|UMLS:C0028864|OpenCyc:Mx4rvj7pZpwpEbGdrcN5Y29ycA|BIRNLEX:1646|MA:0001095|ZFA:0000405|EHDAA2:0001284|UMLS:C0028864|HBA:9316|TAO:0000405|NCIT:C12758|EHDAA:3736|BAMS:3n|XAO:0003090|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=488|VHOG:0000692|BM:MB-IIIN|EMAPA:17574|AAO:0010468|FMA:50864|BAMS:IIIn|GAID:829|MBA:832	hp.json	nerve III|nervus oculomotorius|third cranial nerve|occulomotor|oculomotor III|cranial nerve III|oculomotor III nerve|oculomotor nerve tree|CN-III|oculomotor nerve or its root|3n|oculomotor nerve [III]|nervus oculomotorius [III]	http://purl.obolibrary.org/obo/UBERON_0001643		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
HP:0008467	biolink:PhenotypicFeature	Thoracic hemivertebrae	Absence of one half of the vertebral body in the thoracic spine.	UMLS:C4020799|UMLS:C0432152|SNOMEDCT_US:95304000	hp.json	Midthoracic hemivertebrae	http://purl.obolibrary.org/obo/HP_0008467		
CHEBI:38631	biolink:ChemicalSubstance	aminoalkylindole			hp.json	aminoalkylindoles	http://purl.obolibrary.org/obo/CHEBI_38631		3_STAR
HP:0008462	biolink:PhenotypicFeature	Cervical instability		UMLS:C1863314	hp.json		http://purl.obolibrary.org/obo/HP_0008462		
HP:0008461	biolink:PhenotypicFeature	Cervical vertebral facet hypoplasia		UMLS:C4024673	hp.json		http://purl.obolibrary.org/obo/HP_0008461		
UBERON:0001640	biolink:AnatomicalEntity	celiac artery	The first major branch of the abdominal aorta.	UMLS:C0007569|NCIT:C52846|EMAPA:35202|MA:0001931|FMA:50737|EHDAA2:0004519|MESH:D002445|GAID:483	hp.json	coeliac trunck|coeliac artery|truncus cœliacus|celiac trunk|arteria coeliaca|truncus coeliacus|truncus coeliacus|arteria cœliaca|coeliac trunk|celiac tree|coeliac axis	http://purl.obolibrary.org/obo/UBERON_0001640		human_reference_atlas|uberon_slim|pheno_slim
PR:P05533	biolink:Protein	lymphocyte antigen 6A-2/6E-1 (mouse)	A lymphocyte antigen 6A-2/6E-1 that is encoded in the genome of mouse.	UniProtKB:P05533	hp.json	Stem cell antigen 1 (mouse)|TAP (mouse)|T-cell-activating protein (mouse)|SCA-1 (mouse)|mLy6a|Ly6|Ly-6A.2/Ly-6E.1 (mouse)|Ly6a	http://purl.obolibrary.org/obo/PR_P05533		
HP:0008464	biolink:PhenotypicFeature	Absent spinous processes of lower thoracic and lumbar vertebrae		UMLS:C4024671	hp.json		http://purl.obolibrary.org/obo/HP_0008464		
PR:P05532	biolink:Protein	mast/stem cell growth factor receptor Kit (mouse)	A mast/stem cell growth factor receptor that is encoded in the genome of mouse.	UniProtKB:P05532	hp.json	SCFR (mouse)|mKIT|CD117 (mouse)|tyrosine-protein kinase Kit (mouse)|proto-oncogene c-Kit (mouse)|Sl|Kit	http://purl.obolibrary.org/obo/PR_P05532		
HP:0008463	biolink:PhenotypicFeature	Central vertebral hypoplasia		UMLS:C4024672	hp.json		http://purl.obolibrary.org/obo/HP_0008463		
UBERON:0013691	biolink:AnatomicalEntity	buttock	A zone of soft tissue located on the posterior of the lateral side of the pelvic region corresponding to the gluteal muscles.	EFO:0003070|UMLS:C0006497|NCIT:C89806|FMA:25245|CALOHA:TS-2224|MESH:D002081	hp.json	regio glutealis|gluteal region|buttocks|gluteal part of pelvic girdle|clunis	http://purl.obolibrary.org/obo/UBERON_0013691		pheno_slim|efo_slim
HP:0033400	biolink:PhenotypicFeature	Acute abdomen	A sudden onset of abdominal pain with associated nausea or vomiting. The acute abdomen may be caused by an infection, inflammation, vascular occlusion, or obstruction.		hp.json	Acute abdominal pain	http://purl.obolibrary.org/obo/HP_0033400		
UBERON:0013697	biolink:AnatomicalEntity	exocrine pancreas epithelium	Epithelium lining the exocrine pancreas.	CALOHA:TS-2108	hp.json	epithelium of exocrine pancreas|exocrine pancreas epithelial cell	http://purl.obolibrary.org/obo/UBERON_0013697		
UBERON:0013698	biolink:AnatomicalEntity	strand of pubic hair	A hair in the frontal genital area of adolescent and adult humans, located on and around the sex organs, the crotch, and sometimes at the top of the inside of the thighs, in the pubic region around the pubis bone.	NCIT:C33424|FMA:54319|UMLS:C1305636	hp.json	pubic hair	http://purl.obolibrary.org/obo/UBERON_0013698		pheno_slim
UBERON:0013699	biolink:AnatomicalEntity	strand of axillary hair	A strand of hair that is part of a axilla.	FMA:54253	hp.json	axillary hair|hair of axilla|axilla hair	http://purl.obolibrary.org/obo/UBERON_0013699		pheno_slim
HP:0033402	biolink:PhenotypicFeature	Digital ischemia	Restriction of arterial blood supply to a digit (finger or toe) associated with insufficient oxygenation to support the metabolic requirements of the digit. Clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis.		hp.json		http://purl.obolibrary.org/obo/HP_0033402		
HP:0033401	biolink:PhenotypicFeature	Tissue ischemia	Ischemia is defined as a restriction of arterial blood supply to a tissue associated with insufficient oxygenation to support the metabolis requirements of the tissue. Depending on the involved tissues, clinical manifestations may include pain, pallor, lack of pulse, coldness, paresthesia, and paralysis. Additional associated manifestations include hemodynamic parameters (reduced blood pressure distal to the site of restricted arterial supply) and angiographic evidence of arterial occclusion.		hp.json		http://purl.obolibrary.org/obo/HP_0033401		
UBERON:0013694	biolink:AnatomicalEntity	brain endothelium	Vascular endothelium found in blood vessels of the blood-brain-barrier.	CALOHA:TS-0092|BTO:0001852|BTO:0003248	hp.json	cerebromicrovascular endothelium	http://purl.obolibrary.org/obo/UBERON_0013694		
UBERON:0013695	biolink:AnatomicalEntity	colon endothelium	Vascular endothelium found in colon blood vessels.	CALOHA:TS-0162	hp.json	colonic endothelium|colon endothelial cells|colonic endothelial cell|colorectal endothelium|colorectal endothelial cell|colon endothelial cell	http://purl.obolibrary.org/obo/UBERON_0013695		
UBERON:0013696	biolink:AnatomicalEntity	tonsil epithelium	The epithelium that forms the surface of the tonsil dips into the underlying connective tissue in numerous places, forming crypts kown as tonsillar crypts. Stratified squamous epithelium, that may be heavily infiltrated by lymphocytes. Epithelial cells are present in the germinal as well as in the periphery of the nodule.	CALOHA:TS-2070	hp.json	epithelium of tonsil|tonsil epithelial cell	http://purl.obolibrary.org/obo/UBERON_0013696		
HP:0033408	biolink:PhenotypicFeature	Elevated circulating acetoacetic acid concentration	An increased level of acetoacetic acid in the blood circulation. Acetoacetic acid is one of the predominant ketone bodies.		hp.json		http://purl.obolibrary.org/obo/HP_0033408		
HP:0033407	biolink:PhenotypicFeature	Elevated urine acetoacetic acid level	Elevated amount of acetoacetic acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033407		
GO:0048709	biolink:BiologicalProcess	oligodendrocyte differentiation	The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0048709		
HP:0033409	biolink:PhenotypicFeature	Elevated urinary 2-hydroxybutyric acid	An increased amount of 2-hydroxybutyric acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033409		
HP:0033404	biolink:PhenotypicFeature	Intestinal ischemia	Restriction of arterial blood supply to the intestine associated with insufficient oxygenation to support the metabolic requirements of the tissue. Acute intestinal ischemia can involve the small or large intestine, and usually presents with sudden severe non-specific abdominal pain.		hp.json		http://purl.obolibrary.org/obo/HP_0033404		
HP:0033403	biolink:PhenotypicFeature	Testicular ischemia	Restriction of arterial blood supply to a testis associated with insufficient oxygenation to support the metabolic requirements of the tissue. Clinical manifestations may include pain and swelling of the affected testis.		hp.json		http://purl.obolibrary.org/obo/HP_0033403		
HP:0033406	biolink:PhenotypicFeature	Elevated circulating o-phosphoethanolamine concentration	An increased concentration of o-phosphoethanolamine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033406		
GO:0048705	biolink:BiologicalProcess	skeletal system morphogenesis	The process in which the anatomical structures of the skeleton are generated and organized.		hp.json	skeletal morphogenesis	http://purl.obolibrary.org/obo/GO_0048705		
HP:0033405	biolink:PhenotypicFeature	Abnormal circulating organic amino compound concentration	Any deviation from the normal concentration of an organic amino compound, defined as a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.		hp.json		http://purl.obolibrary.org/obo/HP_0033405		
UBERON:0013680	biolink:AnatomicalEntity	inner canthus of left eye	An inner canthus that is part of a left eye.	FMA:59320	hp.json	medial angle of left eye|medial canthus of left eye|left medial palpebral commissure|left medial canthus|left inner canthus	http://purl.obolibrary.org/obo/UBERON_0013680		
UBERON:0013686	biolink:AnatomicalEntity	anatomical conduit space	An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified].	FMA:9338	hp.json	foramen space	http://purl.obolibrary.org/obo/UBERON_0013686		
GO:0048714	biolink:BiologicalProcess	positive regulation of oligodendrocyte differentiation	Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.		hp.json	up regulation of oligodendrocyte differentiation|activation of oligodendrocyte differentiation|stimulation of oligodendrocyte differentiation|upregulation of oligodendrocyte differentiation|up-regulation of oligodendrocyte differentiation	http://purl.obolibrary.org/obo/GO_0048714		
HP:0033411	biolink:PhenotypicFeature	Lower extremity akinesia	Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily in the lower extremities.		hp.json		http://purl.obolibrary.org/obo/HP_0033411		
UBERON:0013687	biolink:AnatomicalEntity	pericranium	Periosteum that is part of a skull.	FMA:76623	hp.json	periosteum externum cranii	http://purl.obolibrary.org/obo/UBERON_0013687		
GO:0048713	biolink:BiologicalProcess	regulation of oligodendrocyte differentiation	Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0048713		
HP:0033410	biolink:PhenotypicFeature	Elevated circulating cartilage oligomeric matrix protein concentration	An increased blood concentration of cartilage oligomeric matrix protein (COMP).		hp.json		http://purl.obolibrary.org/obo/HP_0033410		
HP:0033413	biolink:PhenotypicFeature	Upper extremity hypokinesia	Abnormally diminished movement of the upper extremities. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.		hp.json	Hypokinesia of the upper extremities	http://purl.obolibrary.org/obo/HP_0033413		
UBERON:0013688	biolink:AnatomicalEntity	tonsil germinal center	A germinal center that is part of a tonsil.	CALOHA:TS-1288	hp.json	tonsil reaction center	http://purl.obolibrary.org/obo/UBERON_0013688		
HP:0033412	biolink:PhenotypicFeature	Upper extremity akinesia	Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily in the upper extremities.		hp.json	Akinesia of the upper extremities	http://purl.obolibrary.org/obo/HP_0033412		
UBERON:0013683	biolink:AnatomicalEntity	left dorsal thalamus	A dorsal thalamus that is in_the_left_side_of a diencephalon.	FMA:258716	hp.json	left thalamus	http://purl.obolibrary.org/obo/UBERON_0013683		pheno_slim
UBERON:0013684	biolink:AnatomicalEntity	right dorsal thalamus	A dorsal thalamus that is in_the_right_side_of a diencephalon.	FMA:258714	hp.json	right thalamus	http://purl.obolibrary.org/obo/UBERON_0013684		pheno_slim
UBERON:0013685	biolink:AnatomicalEntity	foramen of skull	Anatomical space that is an opening in a bone of the skull.	Wikipedia:Foramina_of_the_skull|SCTID:276742007|FMA:53165	hp.json	foramina of the skull|cranial foramen|foramen of skull|cranial conduit|foramina of the skull|foramen of skull	http://purl.obolibrary.org/obo/UBERON_0013685		
UBERON:0011024	biolink:AnatomicalEntity	extrinsic extensor muscle of manus	The extrinsic extensor muscles of the hand are located in the back of the forearm and have long tendons connecting them to bones in the hand, where they exert their action.		hp.json	extrinsic extensor muscle of hand	http://purl.obolibrary.org/obo/UBERON_0011024		
HP:0033419	biolink:PhenotypicFeature	Elevated circulating 3-hydroxybutyric acid concentration	Elevation of the 3-hydroxybutyric acid concentration in the blood above the normal range.		hp.json		http://purl.obolibrary.org/obo/HP_0033419		
HP:0033418	biolink:PhenotypicFeature	Elevated circulating 2-hydroxybutyric acid concentration	Elevation of the 2-hydroxybutyric acid concentration in the blood above the normal range.		hp.json		http://purl.obolibrary.org/obo/HP_0033418		
HP:0033415	biolink:PhenotypicFeature	Cardiac tamponade	The accumulation of pericardial fluid with subsequent compression of all cardiac chambers which prevents cardiac filling.		hp.json		http://purl.obolibrary.org/obo/HP_0033415		
UBERON:0013679	biolink:AnatomicalEntity	inner canthus of right eye	An inner canthus that is part of a right eye.	FMA:59319	hp.json	right inner canthus|medial canthus of right eye|medial angle of right eye|right medial palpebral commissure|right medial canthus	http://purl.obolibrary.org/obo/UBERON_0013679		
HP:0033414	biolink:PhenotypicFeature	Lower extremity hypokinesia	Abnormally diminished movement of the lower extremities. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.		hp.json	Hypokinesia of the lower extremities	http://purl.obolibrary.org/obo/HP_0033414		
HP:0033417	biolink:PhenotypicFeature	Elevated circulating hydroxybutyric acid concentration	An increased concentration in the blood circulation of a hydroxybutyric acid, that is, of a compound comprising a butyric acid core carrying at least one hydroxy substituent.		hp.json		http://purl.obolibrary.org/obo/HP_0033417		
GO:0048715	biolink:BiologicalProcess	negative regulation of oligodendrocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation.		hp.json	downregulation of oligodendrocyte differentiation|down-regulation of oligodendrocyte differentiation|down regulation of oligodendrocyte differentiation|inhibition of oligodendrocyte differentiation	http://purl.obolibrary.org/obo/GO_0048715		
HP:0033416	biolink:PhenotypicFeature	Hip adductor weakness	Reduced ability to bring the leg toward the midline of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0033416		
PR:P05555	biolink:Protein	integrin alpha-M (mouse)	An integrin alpha-M that is encoded in the genome of mouse.	UniProtKB:P05555	hp.json	mITGAM|cell surface glycoprotein MAC-1 subunit alpha (mouse)|CR-3 alpha chain (mouse)|Itgam|CD11b (mouse)|CD11 antigen-like family member B (mouse)|leukocyte adhesion receptor MO1 (mouse)	http://purl.obolibrary.org/obo/PR_P05555		
UBERON:0001689	biolink:AnatomicalEntity	malleus bone	The malleus or hammer is a hammer-shaped small bone or ossicle of the middle ear which connects with the incus and is attached to the inner surface of the eardrum. The word is Latin for hammer. It transmits the sound vibrations from the eardrum to the incus. The malleus is unique to mammals, and evolved from a lower jaw bone in basal amniotes called the articular, which still forms part of the jaw joint in reptiles. Embryologically it is derived from the first pharyngeal arch along with the rest of the bones of mastication, such as the maxilla and mandible. [WP,unvetted].	NCIT:C33051|MA:0001216|UMLS:C0024631|VHOG:0000690|EMAPA:18584|MESH:D008307|FMA:52753|GAID:867	hp.json	malleus|anguloarticular - malleus|malleus	http://purl.obolibrary.org/obo/UBERON_0001689		uberon_slim|pheno_slim
HP:0033422	biolink:PhenotypicFeature	Pulmonary artery adventitial fibrosis	Increased amount of collagen, proteoglycans, and other extracellular matrix proteins resulting in scarring and thickening in the adventia of the pulmonary arterial tree.		hp.json		http://purl.obolibrary.org/obo/HP_0033422		
HP:0033421	biolink:PhenotypicFeature	Pulmonary artery intimal thickening	Increased thickness of the intimal layer of the pulmonary artery. Throughout the pulmonary arterial tree, the thin intima consists of a non-fenestrated monolayer of endothelial cells lining the vessel lumen, as well as a sub-endothelial interstitium that extends to the internal elastic lamina. Intimal thickness in human lung ranges from 1-16% of total wall thickness. Pulmonary artery intimal thickening can be defined as a relative intima thickness to the thickness of the vessel wall of over 10%.		hp.json		http://purl.obolibrary.org/obo/HP_0033421		
HP:0033424	biolink:PhenotypicFeature	Pulmonary arterial hypertension with lack of acute response to NO challenge	A form of pulmonary arterial hypertension with lack of adequate hemodynamic response to NO challenge (adequate response is defined as a reduction of mean pulmonary artery pressure (mPAP) of at least 10 mmHg to reach an absolute value of mPAP 40 mmHg or less with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm).		hp.json		http://purl.obolibrary.org/obo/HP_0033424		
UBERON:0013678	biolink:AnatomicalEntity	anatomical line between inner canthi	An anatomical line of the face that connects the two inner (medial) canthi of the eye. The length of this line is known as the inter canthal distance.	FMA:284806	hp.json	inter inner canthal line|bicanthal plane|inter-canthal line|inter medial canthal line|intercanthal line	http://purl.obolibrary.org/obo/UBERON_0013678		
HP:0033423	biolink:PhenotypicFeature	Pulmonary arterial hypertension with positive acute response to NO challenge	A form of pulmonary arterial hypertension in which there is a reduction of mean pulmonary artery pressure (mPAP) at leasy 10 mmHg to reach an absolute value of mPAP not more than 40 mmHg with an increased or unchanged cardiac output (CO) in response to inhaled nitric oxide at 10-20 ppm.		hp.json		http://purl.obolibrary.org/obo/HP_0033423		
HP:0033420	biolink:PhenotypicFeature	Pulmonary arterial plexiform lesion	Focal proliferation of pulmonary artery endothelial cells, leading to the formation of complex capillary-like channels.		hp.json		http://purl.obolibrary.org/obo/HP_0033420		
HP:0033429	biolink:PhenotypicFeature	Neuroinflammation	Activation of the brain's innate immune system in response to an inflammatory challenge and is characterized by a host of cellular and molecular changes within the brain.		hp.json		http://purl.obolibrary.org/obo/HP_0033429		
UBERON:0001691	biolink:AnatomicalEntity	external ear	Part of the ear external to the tympanum (eardrum). It typically consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull[GO].	EMAPA:16991|EHDAA:3786|MAT:0000147|BIRNLEX:1705|AAO:0011037|OpenCyc:Mx4rwOHtXJwpEbGdrcN5Y29ycA|EV:0100354|EHDAA2:0000462|MIAA:0000147|MESH:D004431|UMLS:C1269548|XAO:0000190|VHOG:0000311|FMA:52781|UMLS:C0013453|BTO:0002100|EFO:0004221|NCIT:C12292|UMLS:C0013453|GAID:104|MA:0000258	hp.json	auricular region of head|auricular region|outer ear|auris externa	http://purl.obolibrary.org/obo/UBERON_0001691		pheno_slim|efo_slim|uberon_slim
UBERON:0001690	biolink:AnatomicalEntity	ear	Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.	CALOHA:TS-1165|EHDAA2:0000423|MAT:0000138|OpenCyc:Mx4rvVjL05wpEbGdrcN5Y29ycA|BIRNLEX:1062|AAO:0011014|BTO:0000368|MIAA:0000138|MESH:D004423|UMLS:C0013443|galen:Ear|EV:0100353|EMAPA:16193|NCIT:C12394|OpenCyc:Mx4rvViXS5wpEbGdrcN5Y29ycA|FMA:52780|GAID:62|UMLS:C0013443|VHOG:0000330|EFO:0000826|MA:0000236|UMLS:C0521421|EHDAA:502|XAO:0000189	hp.json	auris|auditory apparatus	http://purl.obolibrary.org/obo/UBERON_0001690		organ_slim|pheno_slim|efo_slim|uberon_slim
HP:0033426	biolink:PhenotypicFeature	Pulmonary air embolism	Venous air embolism is a consequence of air being introduced into the venous circulation, and subsequently to the right heart, and pulmonary circulation. When small amounts of air reach pulmonary circulation they can be removed by gas diffusion across the arteriolar wall into the alveoli, amounts of gas exceeding 50 ml can cause pulmonary outflow tract obstruction with or without concomitant arterial embolisation.		hp.json	Venous air embolism	http://purl.obolibrary.org/obo/HP_0033426		
GO:0048729	biolink:BiologicalProcess	tissue morphogenesis	The process in which the anatomical structures of a tissue are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0048729		
HP:0033425	biolink:PhenotypicFeature	Periungual erythema	Erythema (redness of the skin caused by hyperemia in superficial capillaries) in the region surrounding a fingernail or toe nail.		hp.json		http://purl.obolibrary.org/obo/HP_0033425		
HP:0033428	biolink:PhenotypicFeature	Systemic autoinflammation	Dysregulation of the innate immune system characterized by systemic pathobiology, i.e., with symptoms that can affect the entire body.		hp.json		http://purl.obolibrary.org/obo/HP_0033428		
HP:0033427	biolink:PhenotypicFeature	Pulmonary capillary angioectasia	Focal accumulation of dilated pulmonary capillaries.		hp.json		http://purl.obolibrary.org/obo/HP_0033427		
UBERON:0001697	biolink:AnatomicalEntity	orbit of skull	Subdivision of skeleton that is an anterolateral part of the cranium and structurally supports the eye. Includes bones formed and located in sclerotic layer of eyeball.	FMA:53074|GAID:223|ZFA:0001410|NCIT:C12347|galen:Orbit|MESH:D009915|TAO:0001410|MA:0002482|UMLS:C0029180|BTO:0004687|XAO:0003171|OpenCyc:Mx4rvW8EgZwpEbGdrcN5Y29ycA	hp.json	eye socket|bony orbit|orbit of skull|orbit	http://purl.obolibrary.org/obo/UBERON_0001697		uberon_slim|vertebrate_core|pheno_slim
HP:0008499	biolink:PhenotypicFeature	High hypermetropia	A severe form of hypermetropia with over +5.00 diopters.	UMLS:C4024665	hp.json	Severe farsightedness|High-grade hypermetropia|High hyperopia|Severe long-sightedness	http://purl.obolibrary.org/obo/HP_0008499		
HP:0008498	biolink:PhenotypicFeature	No permanent dentition		UMLS:C4024666	hp.json	Missing adult teeth|Absence of secondary dentition|No adult dentition|No secondary dentition|Absence of adult teeth	http://purl.obolibrary.org/obo/HP_0008498		
HP:0008494	biolink:PhenotypicFeature	Inferior lens subluxation	Partial displacement of the lens in the inferior direction.	UMLS:C2036842	hp.json	Inferior subluxated lens	http://purl.obolibrary.org/obo/HP_0008494		
CHEBI:26607	biolink:ChemicalSubstance	saturated fatty acid	Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess.	PMID:20237329|PMID:16492686|PMID:19763019	hp.json	saturated fatty acids|SFAs|saturated fatty acid|SFA	http://purl.obolibrary.org/obo/CHEBI_26607		3_STAR
UBERON:0001695	biolink:AnatomicalEntity	squamous part of temporal bone	A bone which is fused with the temporal bone in many mammals and forms part of the cheek region articulating with quadrate and pterygoid in other vertebrates.	VHOG:0001561|MA:0001473|EMAPA:18021|AAO:0000574|FMA:52883	hp.json	temporal bone squamous part|squamosum|pars squamosa ossis temporalis|squamosal|squama|os squamosum|squamous bone|squama temporalis|squamosal bone|squama temporalis|pars squamosa (os temporale)	http://purl.obolibrary.org/obo/UBERON_0001695		pheno_slim
HP:0008497	biolink:PhenotypicFeature	Congenital craniofacial dysostosis		UMLS:C4024667	hp.json		http://purl.obolibrary.org/obo/HP_0008497		
UBERON:0001694	biolink:AnatomicalEntity	petrous part of temporal bone	The petrous portion of the temporal bone or pyramid is pyramidal and is wedged in at the base of the skull between the sphenoid and occipital bones. Directed medially, forward, and a little upward, it presents for examination a base, an apex, three surfaces, and three angles, and contains, in its interior, the essential parts of the organ of hearing. The petrous portion is among the most basal elements of the skull and forms part of the endocranium.[WP,unvetted].	MESH:D010579|UMLS:C1261761|GAID:234|MA:0001477|EMAPA:17683|EHDAA2:0001452|FMA:52871|VHOG:0001553|NCIT:C32316	hp.json	petromastoid part of temporal bone|petrosal bone|pars petrosa (os temporale)|pars petrosa ossis temporalis|temporal bone petrous part|petrosal|petrous bone	http://purl.obolibrary.org/obo/UBERON_0001694		uberon_slim
HP:0008496	biolink:PhenotypicFeature	Multiple rows of eyelashes		UMLS:C0423848|SNOMEDCT_US:95339000|UMLS:C3550336	hp.json	Two rows of eyelashes|Extra rows of eyelashes|Multiple rows of eyelashes|Double row of eyelashes	http://purl.obolibrary.org/obo/HP_0008496		
NCBITaxon:58023	biolink:OrganismalEntity	Tracheophyta		GC_ID:1	hp.json	vascular plants|vascular plants	http://purl.obolibrary.org/obo/NCBITaxon_58023		
NCBITaxon:58024	biolink:OrganismalEntity	Spermatophyta		GC_ID:1	hp.json	seed plants|seed plants	http://purl.obolibrary.org/obo/NCBITaxon_58024		
UBERON:0001679	biolink:AnatomicalEntity	ethmoid bone	A bone in the skull that separates the nasal cavity from the brain. As such, it is located at the roof of the nose, between the two orbits. The cubical bone is lightweight due to a spongy construction. The ethmoid bone is one of the bones that makes up the orbit of the eye[WP].	EMAPA:19018|GAID:212|NCIT:C12711|BTO:0004140|OpenCyc:Mx4rvuUPh5wpEbGdrcN5Y29ycA|UMLS:C0015027|MA:0001483|VHOG:0001317|FMA:52740|MESH:D005004	hp.json	os ethmoidale|ethmoid|os ethmoidale|ethmoidal bone	http://purl.obolibrary.org/obo/UBERON_0001679		uberon_slim|pheno_slim
UBERON:0001678	biolink:AnatomicalEntity	temporal bone	The large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous.	EHDAA:6035|SCTID:181795004|Wikipedia:Temporal_bone|FMA:52737|OpenCyc:Mx4rvbkAk5wpEbGdrcN5Y29ycA|MESH:D013701|GAID:232|MA:0001476|NCIT:C12797|EMAPA:17682|VHOG:0000800|UMLS:C0039484	hp.json	os temporale|os temporale	http://purl.obolibrary.org/obo/UBERON_0001678		uberon_slim|pheno_slim
HP:0033433	biolink:PhenotypicFeature	Ileocecal ulcer	An erosion of the mucous membrane in the region connecting the ileum and cecum.		hp.json	Ileo-cecal ulcer	http://purl.obolibrary.org/obo/HP_0033433		
GO:0048736	biolink:BiologicalProcess	appendage development	The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.		hp.json		http://purl.obolibrary.org/obo/GO_0048736		
HP:0033432	biolink:PhenotypicFeature	Opportunistic viral infection			hp.json		http://purl.obolibrary.org/obo/HP_0033432		
HP:0033435	biolink:PhenotypicFeature	Abnormal circulating keto acid concentration	A deviation from the normal concentration of a keto acid in the blood circulation. Keto acids or ketoacids are organic compounds that contain a carboxylic acid group and a ketone group.		hp.json		http://purl.obolibrary.org/obo/HP_0033435		
HP:0033434	biolink:PhenotypicFeature	Nasal septum perforation	A full-thickness defect of the nasal septum.		hp.json	Nasal-septum perforation|Perforation of the nasal septum	http://purl.obolibrary.org/obo/HP_0033434		
CL:1001516	biolink:Cell	intestinal enteroendocrine cell	The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract.		hp.json		http://purl.obolibrary.org/obo/CL_1001516		
GO:0048732	biolink:BiologicalProcess	gland development	The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion.		hp.json		http://purl.obolibrary.org/obo/GO_0048732		
GO:0048731	biolink:BiologicalProcess	system development	The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.		hp.json		http://purl.obolibrary.org/obo/GO_0048731		goslim_mouse
UBERON:0011004	biolink:AnatomicalEntity	pharyngeal arch cartilage	A cartilage element that is part of a splanchnocranium.	ZFA:0001460|EFO:0003689|TAO:0001460	hp.json	pharyngeal arch cartilages|splanchnocranium cartilage	http://purl.obolibrary.org/obo/UBERON_0011004		efo_slim
HP:0033431	biolink:PhenotypicFeature	Cytomegalovirus colitis	A form of cytomegalovirus infection characterized by infection and inflammation of the colon.		hp.json	CMV colitis	http://purl.obolibrary.org/obo/HP_0033431		
GO:0048730	biolink:BiologicalProcess	epidermis morphogenesis	The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.		hp.json	hypodermis morphogenesis	http://purl.obolibrary.org/obo/GO_0048730		
HP:0033430	biolink:PhenotypicFeature	Non-infectious meningitis	Inflammation of the layers of tissue that cover the brain and spinal cord (meninges) and of the fluid-filled space between the meninges (subarachnoid space) when it is caused by disorders that are not infections or by drugs or vaccines.		hp.json		http://purl.obolibrary.org/obo/HP_0033430		
UBERON:0001680	biolink:AnatomicalEntity	lacrimal bone	The irregularly thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla.	MA:0001486|FMA:52741|NCIT:C32906|VHOG:0001149|UMLS:C0222733	hp.json	infraorbital 1|lacrymal bone - infraorbital 1|lacrimal - infraorbital 1|lachrymal bone|lacrimal|os lacrimale|lachrymal bone - infraorbital 1|lacrymal bone	http://purl.obolibrary.org/obo/UBERON_0001680		vertebrate_core|pheno_slim|uberon_slim
HP:0033437	biolink:PhenotypicFeature	Elevated circulating 4-methyl-2-oxopentanoic acid concentration	Abnormal increase of the concentration of 4-methyl-2-oxopentanoic acid in the blood circulation.		hp.json	Increased circulating alpha-ketoisocaproic acid concentration	http://purl.obolibrary.org/obo/HP_0033437		
HP:0033436	biolink:PhenotypicFeature	Elevated circulating 3-methyl-2-oxovaleric acid concentration	An abnormally increased concentration of 3-methyl-2-oxovaleric acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033436		
HP:0033439	biolink:PhenotypicFeature	Elevated circulating decenoylcarnitine concentration	Increased concentration of decenoylcarnitine in the blood circulation.		hp.json	Elevated circulating O-decenoylcarnitine concentration|Elevated plasma decenoylcarnitine, C10:1	http://purl.obolibrary.org/obo/HP_0033439		
GO:0048738	biolink:BiologicalProcess	cardiac muscle tissue development	The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.		hp.json	heart muscle development	http://purl.obolibrary.org/obo/GO_0048738		
HP:0033438	biolink:PhenotypicFeature	Elevated circulating myoglobin concentration	An increased blood concentration of myoglobin.		hp.json		http://purl.obolibrary.org/obo/HP_0033438		
UBERON:0001686	biolink:AnatomicalEntity	auditory ossicle bone	One of 3 small bones contained within the middle ear space and serve to transmit sounds from the air to the fluid-filled labyrinth. The absence of the auditory ossicles would constitute a moderate-to-severe hearing loss. The term 'ossicles' literally means 'tiny bones' and commonly refers to the auditory ossicles, though the term may refer to any small bone throughout the body. [WP,unvetted].	EHDAA2:0001183|XAO:0000214|VHOG:0000461|MA:0000254|AAO:0011015|EHDAA:5697|NCIT:C32164|FMA:52750|EMAPA:17824|UMLS:C0013450|EV:0100360	hp.json	ear ossicle|ear bone|auditory ossicle|ear ossicles|ossicle of inner ear|auditory bone|ossicle of ear|middle ear ossicle|middle ear bone|ossicular chain|ossicle	http://purl.obolibrary.org/obo/UBERON_0001686		uberon_slim|pheno_slim
UBERON:0001685	biolink:AnatomicalEntity	hyoid bone	A horseshoe shaped bone situated in the anterior midline of the neck between the chin and the thyroid cartilage. The hyoid bone provides attachment to the muscles of the floor of the mouth and the tongue above, the larynx below, and the epiglottis and pharynx behind. [WP,modified].	MESH:D006928|FMA:52749|Wikipedia:Hyoid_bone|NCIT:C32752|EMAPA:18650|GAID:197|MA:0001484|AAO:0000684|UMLS:C0020417|VHOG:0001325|SCTID:263352000	hp.json	os hyoideum|hyoid bone|lingual bone|os hyoideum|hyoid|hyoid bone|lingual bone|hyoid|hyoideum|os hyoideum|os hyoideum|hyoideum	http://purl.obolibrary.org/obo/UBERON_0001685		uberon_slim|pheno_slim
UBERON:0001688	biolink:AnatomicalEntity	incus bone	The incus or anvil is the anvil-shaped small bone or ossicle in the middle ear. It connects the malleus to the stapes. It was first described by Alessandro Achillin of Bologna. The incus transmits sound vibrations from the malleus to the stapes. The incus only exists in mammals, and is derived from a reptilian upper jaw bone, the quadrate bone. Embryologically it is derived from the first pharyngeal arch along with the rest of the bones of mastication, such as the maxilla and mandible. [WP,unvetted].	GAID:866|MESH:D007188|MA:0001215|UMLS:C0021181|EMAPA:18583|NCIT:C32770|VHOG:0000689|FMA:52752	hp.json	quadrate - incus|incus|incus bone	http://purl.obolibrary.org/obo/UBERON_0001688		uberon_slim|pheno_slim
UBERON:0001687	biolink:AnatomicalEntity	stapes bone	The stapes or stirrup is the stirrup-shaped small bone or ossicle in the middle ear which is attached to the incus laterally and to the fenestra ovalis, the 'oval window' medially. The oval window is adjacent to the vestibule of the inner ear. The stapes is the smallest and lightest bone in the human body. The stapes transmits the sound vibrations from the incus to the membrane of the inner ear inside the fenestra ovalis. The stapes is also stabilized by the stapedius muscle, which is innervated by the facial nerve. In non-mammalian vertebrates, the bone homologous to the stapes is usually called the columella; however, in reptiles, either term may be used[WP,unvetted].	MA:0001217|UMLS:C0038152|NCIT:C33612|EMAPA:18585|OpenCyc:Mx4rv5UnkZwpEbGdrcN5Y29ycA|FMA:52751|MESH:D013199|VHOG:0000688|GAID:868	hp.json	stilus columellare|stirrup|columellare|columella|os intermedium|mesostapediale|mediostapediale|stapellos|stelidium|stapes|interstapediale|columella auris|os columellare	http://purl.obolibrary.org/obo/UBERON_0001687		uberon_slim|pheno_slim
UBERON:0001682	biolink:AnatomicalEntity	palatine bone	A paired dermal bone situated in the mid-palate[Palaeos].	TAO:0000015|FMA:52746|EMAPA:36619|MA:0001495|UMLS:C0222734|NCIT:C52745	hp.json	os palatinum|dermopalatine|palatum|palate bone|palatine	http://purl.obolibrary.org/obo/UBERON_0001682		pheno_slim|uberon_slim
UBERON:0001681	biolink:AnatomicalEntity	nasal bone	One of two small oblong bones, varying in size and form in different individuals; they are placed side by side at the middle and upper part of the face, and form, by their junction, 'the bridge' of the nose[WP]. Paired dermal bones, likened to a bone tube, positioned lateral to the supraethmoid. Nasal bones are transversed by the anterior most part of the supraorbital canals and bear one neuromast foramen in zebrafish[ZFA].	GAID:222|ZFA:0000365|EMAPA:19202|MESH:D009295|UMLS:C0027422|FMA:52745|VHOG:0001370|NCIT:C33157|TAO:0000365|AAO:0000312|MA:0001494|OpenCyc:Mx4rwGOTZJwpEbGdrcN5Y29ycA	hp.json	os nasale|nasals|nasal bones	http://purl.obolibrary.org/obo/UBERON_0001681		vertebrate_core|pheno_slim|uberon_slim
UBERON:0001684	biolink:AnatomicalEntity	mandible	A dentary bone that is the only bone in one of the lateral halves of the lower jaw skeleton.	CALOHA:TS-2225|NCIT:C12290|FMA:52748|BTO:0001748|MA:0001487|UMLS:C0024687|EFO:0001965|galen:Mandible|EHDAA2:0001059|EHDAA:8007|GAID:68|MESH:D008334|EMAPA:18290	hp.json	mandibular series|lower mandibula|mandibulla|mandibula|lower jaw bone|mandibula|mammaliam mandible|lower jaw|inferior maxillary bone	http://purl.obolibrary.org/obo/UBERON_0001684		uberon_slim|pheno_slim|efo_slim
UBERON:0001683	biolink:AnatomicalEntity	jugal bone	The quadrilateral bone that forms the prominence of the cheek.	GAID:225|EMAPA:25111|FMA:52747|MA:0001497|VHOG:0001638|MFMO:0000146	hp.json	zygoma|malar bone|orbital bone|zygomatic|cheek bone|jugal|os zygomaticum|os zygomaticus|zygomatic bone|os zygomaticum|jugale|zygoma|jugal bone	http://purl.obolibrary.org/obo/UBERON_0001683		uberon_slim|pheno_slim
GO:0009135	biolink:BiologicalProcess	purine nucleoside diphosphate metabolic process	The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.		hp.json	purine nucleoside diphosphate metabolism	http://purl.obolibrary.org/obo/GO_0009135		
GO:0009132	biolink:BiologicalProcess	nucleoside diphosphate metabolic process	The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.		hp.json	nucleoside diphosphate metabolism	http://purl.obolibrary.org/obo/GO_0009132		
GO:0009141	biolink:BiologicalProcess	nucleoside triphosphate metabolic process	The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.		hp.json	nucleoside triphosphate metabolism	http://purl.obolibrary.org/obo/GO_0009141		
CHEBI:36063	biolink:ChemicalSubstance	oxytocic	A drug that stimulates contraction of the myometrium. Oxytocics are used to induce labour, obstetric at term, to prevent or control postpartum or postabortion haemorrhage, and to assess foetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (abortifacients).		hp.json	oxytocic agents|oxytocic|oxytocic drugs|uterine stimulants	http://purl.obolibrary.org/obo/CHEBI_36063		3_STAR
CHEBI:36080	biolink:ChemicalSubstance	protein	A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome.		hp.json	proteins	http://purl.obolibrary.org/obo/CHEBI_36080		3_STAR
GO:0009144	biolink:BiologicalProcess	purine nucleoside triphosphate metabolic process	The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.		hp.json	purine nucleoside triphosphate metabolism	http://purl.obolibrary.org/obo/GO_0009144		
HP:0008407	biolink:PhenotypicFeature	Hyperconvex thumb nails		UMLS:C1855290	hp.json	Tightly curved thumb nail	http://purl.obolibrary.org/obo/HP_0008407		
GO:0009150	biolink:BiologicalProcess	purine ribonucleotide metabolic process	The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.		hp.json	purine ribonucleotide metabolism	http://purl.obolibrary.org/obo/GO_0009150		
HP:0008404	biolink:PhenotypicFeature	Nail dystrophy	Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate.	SNOMEDCT_US:87065009|MEDDRA:10028698|UMLS:C0221260	hp.json	Poor nail formation|Onychodystrophy|Dystrophic nails	http://purl.obolibrary.org/obo/HP_0008404		
HP:0008400	biolink:PhenotypicFeature	Onycholysis of distal fingernails	Detachment of the distal fingernails from the nail bed.	UMLS:C4024680	hp.json	Detachment of outermost fingernails	http://purl.obolibrary.org/obo/HP_0008400		
HP:0008402	biolink:PhenotypicFeature	Ridged fingernail	Longitudinal, linear prominences in the fingernail plate.	UMLS:C1849392	hp.json	Ridged fingernail|Ridged fingernails|Longitudinally grooved fingernails	http://purl.obolibrary.org/obo/HP_0008402		
HP:0008401	biolink:PhenotypicFeature	Onychogryposis of toenails	Thickened toenails.	UMLS:C4024679	hp.json	Overgrowth and curving of toenails	http://purl.obolibrary.org/obo/HP_0008401		
CHEBI:36078	biolink:ChemicalSubstance	cholanoid		LIPID_MAPS_class:LMST04	hp.json	cholanoids|bile acids and derivatives	http://purl.obolibrary.org/obo/CHEBI_36078		3_STAR
GO:0000785	biolink:CellularComponent	chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.	NIF_Subcellular:sao1615953555	hp.json	chromosome scaffold|cytoplasmic chromatin|nuclear chromatin	http://purl.obolibrary.org/obo/GO_0000785		
CHEBI:51689	biolink:ChemicalSubstance	enone	An alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.	Wikipedia:Enone	hp.json	enones	http://purl.obolibrary.org/obo/CHEBI_51689		3_STAR
GO:0009117	biolink:BiologicalProcess	nucleotide metabolic process	The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).		hp.json	nucleotide metabolism	http://purl.obolibrary.org/obo/GO_0009117		goslim_pir
GO:0009112	biolink:BiologicalProcess	nucleobase metabolic process	The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.		hp.json	nucleobase metabolism	http://purl.obolibrary.org/obo/GO_0009112		
CHEBI:51683	biolink:ChemicalSubstance	methoxybenzenes	Any aromatic ether that consists of a benzene skeleton substituted with one or more methoxy groups.		hp.json	methoxybenzene	http://purl.obolibrary.org/obo/CHEBI_51683		3_STAR
CHEBI:36043	biolink:ChemicalSubstance	antimicrobial drug	A drug used to treat or prevent microbial infections.		hp.json	antimicrobial drugs	http://purl.obolibrary.org/obo/CHEBI_36043		3_STAR
CHEBI:36044	biolink:ChemicalSubstance	antiviral drug	A substance used in the prophylaxis or therapy of virus diseases.		hp.json	anti-viral drug|anti-virus drug|antiviral drugs	http://purl.obolibrary.org/obo/CHEBI_36044		3_STAR
GO:0000792	biolink:CellularComponent	heterochromatin	A compact and highly condensed form of chromatin that is refractory to transcription.	Wikipedia:Heterochromatin|NIF_Subcellular:sao581845896	hp.json	transcriptionally inactive chromatin|nuclear heterochromatin|transcriptionally silent chromatin	http://purl.obolibrary.org/obo/GO_0000792		
GO:0000791	biolink:CellularComponent	euchromatin	A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.	NIF_Subcellular:sao445485807|Wikipedia:Euchromatin	hp.json	nuclear euchromatin|transcriptionally active chromatin	http://purl.obolibrary.org/obo/GO_0000791		
CHEBI:36059	biolink:ChemicalSubstance	hydroxy monocarboxylic acid anion	Any monocarboxylic acid anion carrying at least one hydroxy substituent.		hp.json	hydroxymonocarboxylic acid anions|hydroxy monocarboxylic acid anions|hydroxymonocarboxylic acid anion	http://purl.obolibrary.org/obo/CHEBI_36059		3_STAR
UBERON:0001628	biolink:AnatomicalEntity	posterior communicating artery	One of a pair of right-sided and left-sided blood vessels in the circle of Willis. It connects the three cerebral arteries of the same side. Anteriorly, it is one portion of the terminal trifurcation of the internal carotid artery. The anterior cerebral artery and the middle cerebral artery are the other two branches of the trifurcation. Posteriorly, it communicates with the posterior cerebral artery.	NCIT:C33357|Wikipedia:Posterior_communicating_artery|SCTID:181314001|MA:0002023|ZFA:0005001|OpenCyc:Mx4rwDDlqpwpEbGdrcN5Y29ycA|EHDAA:3352|TAO:0005001|FMA:50084|RETIRED_EHDAA2:0001487|EHDAA2:0004518|EMAPA:18600|UMLS:C0149559	hp.json	PCS|PCA|arteria cerebri communicans posterior|arteria cerebri communicans posterior|caudal communicating segment|posterior communicating segment of the basilar artery	http://purl.obolibrary.org/obo/UBERON_0001628		vertebrate_core|human_reference_atlas|uberon_slim
UBERON:0001627	biolink:AnatomicalEntity	middle cerebral artery	The middle cerebral artery (MCA) is one of the three major paired arteries that supplies blood to the cerebrum. The MCA arises from the internal carotid and continues into the lateral sulcus where it then branches and projects to many parts of the lateral cerebral cortex. It also supplies blood to the anterior temporal lobes and the insular cortices. The left and right MCAs rise from trifurcations of the internal carotid arteries and thus are connected to the anterior cerebral arteries and the posterior communicating arteries, which connect to the posterior cerebral arteries. The MCAs are not considered a part of the Circle of Willis. [WP,unvetted].	GAID:487|NCIT:C12830|EHDAA2:0001179|FMA:50079|UMLS:C0149566|OpenCyc:Mx4rvh3qQ5wpEbGdrcN5Y29ycA|BTO:0005206|EHDAA:5298|MA:0001935|MESH:D020768|EMAPA:18239	hp.json	arteria cerebri media|Sylvian artery	http://purl.obolibrary.org/obo/UBERON_0001627		human_reference_atlas|uberon_slim
UBERON:0001623	biolink:AnatomicalEntity	dorsal nasal artery	The dorsal nasal artery (nasal artery) is an artery of the head. It is one of the two terminal branches of the ophthalmic artery. [WP,unvetted].	EMAPA:35292|FMA:50000|MA:0001945|UMLS:C0226194|NCIT:C52983	hp.json	dorsal nasal branch of ophthalmic artery|arteria dorsalis nasi|external nasal artery	http://purl.obolibrary.org/obo/UBERON_0001623		human_reference_atlas|uberon_slim
HP:0008437	biolink:PhenotypicFeature	Bifid thoracic vertebrae		UMLS:C2751478	hp.json		http://purl.obolibrary.org/obo/HP_0008437		
HP:0008436	biolink:PhenotypicFeature	Absent/hypoplastic coccyx		UMLS:C1856644	hp.json	Absent/small tailbone|Absent/underdeveloped tailbone	http://purl.obolibrary.org/obo/HP_0008436		
HP:0008439	biolink:PhenotypicFeature	Lumbar hemivertebrae	Absence of one half of the vertebral body in the lumbar spine.	UMLS:C0432149|SNOMEDCT_US:93167001	hp.json		http://purl.obolibrary.org/obo/HP_0008439		
HP:0008438	biolink:PhenotypicFeature	Vertebral arch anomaly	A morphological abnormality of the vertebral arch, i.e., of the posterior part of a vertebra.	UMLS:C1835764	hp.json	Vertebral arch abnormalities	http://purl.obolibrary.org/obo/HP_0008438		
UBERON:0001631	biolink:AnatomicalEntity	thoracic duct	A major lymphatic vessel that drains lymph from the lower body, left appendage, and left thorax into the junction of the left jugular and subclavian veins.	EHDAA2:0004501|FMA:5031|ZFA:0005110|TAO:0005110|UMLS:C0039979|MA:0002801|NCIT:C33768|GAID:1290|MESH:D013897|EMAPA:19310	hp.json	ductus thoracicus|trunk of thoracic duct tree	http://purl.obolibrary.org/obo/UBERON_0001631		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
HP:0008433	biolink:PhenotypicFeature	Reversed usual vertebral column curves		UMLS:C4024676	hp.json		http://purl.obolibrary.org/obo/HP_0008433		
HP:0008432	biolink:PhenotypicFeature	Anterior wedging of L1	An abnormality of the shape of the lumbar vertebra L1 such that it is wedge-shaped (narrow towards the front).	UMLS:C4024677	hp.json		http://purl.obolibrary.org/obo/HP_0008432		
UBERON:0001630	biolink:AnatomicalEntity	muscle organ	Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO].	EV:0100146|ZFA:0005145|XAO:0000172|AAO:0011066|TAO:0005145|EMAPA:37474|VHOG:0001245|OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA|galen:Muscle|SCTID:71616004|MA:0000015|EMAPA:32715|FMA:5022|GAID:131	hp.json	muscle	http://purl.obolibrary.org/obo/UBERON_0001630		pheno_slim|uberon_slim|vertebrate_core|organ_slim
GO:0000768	biolink:BiologicalProcess	syncytium formation by plasma membrane fusion	The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.		hp.json	cell fusion	http://purl.obolibrary.org/obo/GO_0000768		
UBERON:0001633	biolink:AnatomicalEntity	basilar artery	A major artery that supplues the hindbrain and runs along the ventral keel of the hindbrain.	MESH:D001488|UMLS:C0004811|FMA:50542|ZFA:0005002|VHOG:0000237|TAO:0005002|EHDAA2:0000163|EMAPA:17307|EHDAA:5285|MA:0001920|OpenCyc:Mx4rwJTtcZwpEbGdrcN5Y29ycA|GAID:474|NCIT:C12676	hp.json	BA	http://purl.obolibrary.org/obo/UBERON_0001633		unverified_taxonomic_grouping|pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
HP:0008435	biolink:PhenotypicFeature	Absent in utero ossification of vertebral bodies		UMLS:C1842698	hp.json		http://purl.obolibrary.org/obo/HP_0008435		
HP:0008434	biolink:PhenotypicFeature	Hypoplastic cervical vertebrae		UMLS:C1835570	hp.json	Underdeveloped cervical vertebrae|Cervical vertebrae hypoplasia	http://purl.obolibrary.org/obo/HP_0008434		
HP:0008430	biolink:PhenotypicFeature	Anterior beaking of lumbar vertebrae	Anterior tongue-like protrusions of the vertebral bodies of the lumbar spine.	UMLS:C4021541	hp.json	Anterior tongue-like protrusion of lumbar vertebral bodies	http://purl.obolibrary.org/obo/HP_0008430		
UBERON:0001617	biolink:AnatomicalEntity	mental artery	The mental branch of inferior alveolar artery escapes with the nerve at the mental foramen, supplies the chin, and anastomoses with the submental and inferior labial arteries. [WP,unvetted].	NCIT:C52973|MA:0002002|EMAPA:37105|UMLS:C0226144|FMA:49701	hp.json	mental branch of inferior alveolar artery|ramus mentalis (arteria alveolaris inferior)	http://purl.obolibrary.org/obo/UBERON_0001617		human_reference_atlas|uberon_slim
UBERON:0001616	biolink:AnatomicalEntity	maxillary artery	An artery that supplies deep structures of the face. It comes just out behind the neck of the mandible. [WP,unvetted].	FMA:49675|GAID:498|SCTID:181326006|NCIT:C34205|EMAPA:17311|UMLS:C0024949|MA:0001919|EHDAA2:0001069|MESH:D008438|Wikipedia:Maxillary_artery|EHDAA:7357|OpenCyc:Mx4rwDDJ45wpEbGdrcN5Y29ycA	hp.json	arteria maxillaris|arteria maxillaris|internal maxillary artery	http://purl.obolibrary.org/obo/UBERON_0001616		human_reference_atlas|uberon_slim
UBERON:0001619	biolink:AnatomicalEntity	ophthalmic artery	The ophthalmic artery is a branch of the internal carotid artery which supplies branches to supply the eye and other structures in the orbit. It enters the orbit together with the Optic nerve through the Optic foramen/canal. [WP,modified].	OpenCyc:Mx4rvcCxpJwpEbGdrcN5Y29ycA|MESH:D009880|NCIT:C33216|UMLS:C0029078|EHDAA2:0001300|AAO:0010497|MA:0002011|FMA:49868|GAID:503|EHDAA:7363|EMAPA:17007|XAO:0000368	hp.json	opthalmic artery|arteria ophthalmica	http://purl.obolibrary.org/obo/UBERON_0001619		uberon_slim|human_reference_atlas
UBERON:0001618	biolink:AnatomicalEntity	buccal artery	The buccal artery (buccinator artery) is small and runs obliquely forward, between the Pterygoideus internus and the insertion of the Temporalis, to the outer surface of the Buccinator, to which it is distributed, anastomosing with branches of the external maxillary and with the infraorbital. [WP,unvetted].	EMAPA:37073|UMLS:C0226151|NCIT:C52847|MA:0001924|FMA:49754	hp.json	arteria buccalis|arteria buccinatoria	http://purl.obolibrary.org/obo/UBERON_0001618		uberon_slim|human_reference_atlas
UBERON:0001613	biolink:AnatomicalEntity	occipital artery	The occipital artery arises opposite the facial artery, its path is below the posterior belly of digastric to the occipital region. This artery supplies blood to the back of the scalp and sterno-mastoid muscles. Other muscles it supplies are deep muscles in the back and neck. [WP,unvetted].	FMA:49586|UMLS:C0226117|OpenCyc:Mx4rwC1IFJwpEbGdrcN5Y29ycA|EMAPA:37672|NCIT:C33194|MA:0002009	hp.json	arteria occipitalis	http://purl.obolibrary.org/obo/UBERON_0001613		human_reference_atlas|uberon_slim
UBERON:0001612	biolink:AnatomicalEntity	facial artery	A branch of the external carotid artery that supplies structures of the face. [WP,unvetted].	SCTID:181328007|MA:0001950|EMAPA:19213|Wikipedia:Facial_artery|OpenCyc:Mx4rwCt95ZwpEbGdrcN5Y29ycA|FMA:49549|UMLS:C0226109|NCIT:C32578	hp.json	arteria maxillaris externa|arteria maxillaris externa|external maxillary artery	http://purl.obolibrary.org/obo/UBERON_0001612		human_reference_atlas|uberon_slim
GO:0009101	biolink:BiologicalProcess	glycoprotein biosynthetic process	The chemical reactions and pathways resulting in the formation of glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.		hp.json	glycoprotein anabolism|glycoprotein biosynthesis|glycoprotein synthesis|glycoprotein formation	http://purl.obolibrary.org/obo/GO_0009101		
GO:0009100	biolink:BiologicalProcess	glycoprotein metabolic process	The chemical reactions and pathways involving glycoproteins, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.		hp.json	glycoprotein metabolism	http://purl.obolibrary.org/obo/GO_0009100		goslim_drosophila
HP:0008447	biolink:PhenotypicFeature	Hypoplastic coccygeal vertebrae		UMLS:C2751480	hp.json		http://purl.obolibrary.org/obo/HP_0008447		
HP:0008449	biolink:PhenotypicFeature	Progressive cervical vertebral spine fusion		UMLS:C1851129	hp.json		http://purl.obolibrary.org/obo/HP_0008449		
UBERON:0001620	biolink:AnatomicalEntity	central retinal artery	The central retinal artery (retinal artery) branches off the ophthalmic artery, running inferior to the optic nerve within its dural sheath to the eyeball. [WP,unvetted].	GAID:508|FMA:49879|EMAPA:37113|MESH:D012161|NCIT:C52997|UMLS:C0035301|MA:0002038	hp.json	central artery of the retina|retinal artery|central artery of retina|arteria centralis retinae|arteria centralis retinae|Zinn's artery	http://purl.obolibrary.org/obo/UBERON_0001620		human_reference_atlas|uberon_slim
HP:0008444	biolink:PhenotypicFeature	Posterior wedging of vertebral bodies	An abnormality of the shape of vertebrae, such that they are wedge-shaped (narrow towards the back).	UMLS:C1969679	hp.json	Posterior wedging	http://purl.obolibrary.org/obo/HP_0008444		
HP:0008443	biolink:PhenotypicFeature	Neuropathic spinal arthropathy	A progressive disorder of vertebral joint degeneration that occurs in the setting of any condition characterized by decreased afferent innervation, involving loss of deep pain and proprioceptive sensation in the vertebral column. Patients most commonly present with symptoms of lower back pain, sitting imbalance, progressive spinal deformity (usually kyphosis), and an audible clicking sound on changing postures.	UMLS:C0575157|SNOMEDCT_US:298380006	hp.json	Spinal deformities|Charcot spinal arthropathy|Spinal neuroarthropathy	http://purl.obolibrary.org/obo/HP_0008443		
UBERON:0001622	biolink:AnatomicalEntity	lacrimal artery	The lacrimal artery arises close to the optic foramen, and is one of the largest branches derived from the ophthalmic artery: not infrequently it is given off before the artery enters the orbit. It accompanies the lacrimal nerve along the upper border of the Lateral Rectus, supplies the lacrimal gland. [WP,unvetted].	FMA:49927|NCIT:C52948|MA:0001988|EMAPA:37094|UMLS:C0226171	hp.json	a. lacrimalis	http://purl.obolibrary.org/obo/UBERON_0001622		human_reference_atlas|uberon_slim
UBERON:0001621	biolink:AnatomicalEntity	coronary artery	An artery that supplies the myocardium.	galen:CoronaryArtery|MA:0002453|OpenCyc:Mx4rvoL56ZwpEbGdrcN5Y29ycA|VHOG:0001557|EV:0100383|EFO:0002551|EMAPA:19160|ZFA:0005812|UMLS:C0205042|CALOHA:TS-0176|NCIT:C12843|FMA:49893|BTO:0000290	hp.json	coronary vessel|coronary arterial tree	http://purl.obolibrary.org/obo/UBERON_0001621		pheno_slim|efo_slim|uberon_slim
HP:0008445	biolink:PhenotypicFeature	Cervical spinal canal stenosis	An abnormal narrowing of the cervical spinal canal.	UMLS:C1844925	hp.json	Narrow cervical spinal canal	http://purl.obolibrary.org/obo/HP_0008445		
HP:0008440	biolink:PhenotypicFeature	C1-C2 vertebral abnormality	Any abnormality of the atlas and the axis.	UMLS:C4024675	hp.json		http://purl.obolibrary.org/obo/HP_0008440		
HP:0008442	biolink:PhenotypicFeature	Vertebral hyperostosis	Excessive growth of the bones of the vertebral bodies.	UMLS:C1834057	hp.json		http://purl.obolibrary.org/obo/HP_0008442		
HP:0008441	biolink:PhenotypicFeature	Herniation of intervertebral nuclei	The presence of one or more herniated nucleus pulposus of intervertebral disk.	UMLS:C1832597|MSH:D007405|SNOMEDCT_US:73589001|UMLS:C0021818	hp.json	Herniated disc|Herniated disk|Herniated intervertebral nuclei	http://purl.obolibrary.org/obo/HP_0008441		hposlim_core
UBERON:0001606	biolink:AnatomicalEntity	muscle of iris	.	SCTID:280888007|FMA:49154|Wikipedia:Iris_muscle|MA:0001287|EMAPA:35448	hp.json	iris muscle organ|iris muscle|muscle organ of iris	http://purl.obolibrary.org/obo/UBERON_0001606		uberon_slim
UBERON:0001605	biolink:AnatomicalEntity	ciliary muscle	The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted].	UMLS:C0559230|NCIT:C32315|Wikipedia:Ciliary_muscle|MA:0001269|EMAPA:35240|BTO:0000654|FMA:49151|SCTID:280862009	hp.json	musculus ciliarus|ciliaris|Bowman`s muscles|musculus ciliaris|musculus ciliaris|ciliaris	http://purl.obolibrary.org/obo/UBERON_0001605		uberon_slim|pheno_slim
UBERON:0001608	biolink:AnatomicalEntity	dilatator pupillae	A smooth muscle of the eye, running radially in the iris that functions as a dilator. [WP,unvetted].	UMLS:C0229190|BTO:0001371|FMA:49158|EMAPA:35286|MA:0001288|NCIT:C32463	hp.json	pupillary dilator|pupillary muscle|iris dilator muscle|pupil dilator muscle|dilator muscle of pupil|radial muscle of iris|radial muscle|dilator pupillae muscle|musculus dilatator pupillae|iris dilator|pupillary dilator muscle|dilator pupillae muscle|dilator of pupil|radiating fibers|pupil dilator|musculus dilator pupillae|dilator pupillae|musculus dilatator pupillae	http://purl.obolibrary.org/obo/UBERON_0001608		uberon_slim
UBERON:0001607	biolink:AnatomicalEntity	sphincter pupillae	A sphincter muscle that is part of the iris.	FMA:49157|MA:0001289|NCIT:C33586|BTO:0000656|UMLS:C0229189|EMAPA:35788	hp.json	M. sphincter pupillae|pupillary sphincter muscle|pupillary constrictor muscle|circular fibers|pupillary sphincter|musculus sphincter pupillae|sphincter pupillae|iris constrictor|constrictor pupillae|spincter pupillae|sphincter muscle of pupil|iris sphincter|m. sphincter pupillae|iris sphincter muscle|iris constrictor muscle|sphincter pupillae muscle	http://purl.obolibrary.org/obo/UBERON_0001607		uberon_slim
UBERON:0001602	biolink:AnatomicalEntity	medial rectus extraocular muscle	The medial rectus muscle is a muscle in the orbit. As with most of the muscles of the orbit, it is innervated by the inferior division of the oculomotor nerve (Cranial Nerve III). This muscle shares an origin with several other extrinsic eye muscles, the anulus tendineus, or common tendon. It is the largest of the extraocular muscles and its only action is adduction of the eyeball. [WP,unvetted].	ZFA:0000301|FMA:49037|TAO:0000301|NCIT:C33068|AAO:0010113|VHOG:0001127|UMLS:C0582820|MA:0001281	hp.json	m. rectus medialis|medial rectus|medial rectus extraocular muscle|medial recti|medial rectus muscle|musculus rectus medialis|musculus rectus medialis bulbi	http://purl.obolibrary.org/obo/UBERON_0001602		vertebrate_core|pheno_slim|uberon_slim
UBERON:0001601	biolink:AnatomicalEntity	extra-ocular muscle	Skeletal muscle derived from cranial mesoderm and controls eye movements.	TAO:0000511|EMAPA:18234|AAO:0010028|FMA:49033|EFO:0001921|VHOG:0000549|BTO:0001579|CALOHA:TS-0305|MA:0001271|EHDAA2:0000482|EHDAA:5729|ZFA:0000511	hp.json	extraocular muscle|extrinsic eye muscle|extrinsic ocular muscle|musculi externi bulbi oculi|extrinsic muscle of eyeball|extraocular musculature|extraocular skeletal muscle|extra-ocular skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0001601		vertebrate_core|pheno_slim|efo_slim|uberon_slim
UBERON:0001604	biolink:AnatomicalEntity	levator palpebrae superioris	The levator palpebrae superioris (or levator muscle of upper eyelid) is the muscle in the orbit that elevates the superior (upper) eyelid. [WP,unvetted].	UMLS:C0224134|EMAPA:36652|FMA:49041|MA:0001272|NCIT:C52802	hp.json		http://purl.obolibrary.org/obo/UBERON_0001604		uberon_slim|pheno_slim
GO:0000741	biolink:BiologicalProcess	karyogamy	The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.	Wikipedia:Karyogamy	hp.json	nuclear fusion|nuclear fusion during karyogamy	http://purl.obolibrary.org/obo/GO_0000741		
UBERON:0001603	biolink:AnatomicalEntity	lateral rectus extra-ocular muscle	The lateral rectus muscle is a muscle in the orbit. It is one of six extraocular muscles that control the movements of the eye (abduction in this case) and the only muscle innervated by the abducens nerve, cranial nerve VI. [WP,unvetted].	FMA:49038|UMLS:C0582821|AAO:0010107|ZFA:0000383|VHOG:0001129|TAO:0000383|MA:0001280|NCIT:C32945	hp.json	musculus rectus lateralis bulbi|lateral recti|lateral rectus|musculus rectus lateralis|lateral rectus extraocular muscle|lateral extraocular muscle|lateral rectus muscle|posterior rectus|M. rectus lateralis	http://purl.obolibrary.org/obo/UBERON_0001603		vertebrate_core|pheno_slim|uberon_slim
GO:0000740	biolink:BiologicalProcess	nuclear membrane fusion	The joining of 2 or more lipid bilayer membranes that surround the nucleus.		hp.json		http://purl.obolibrary.org/obo/GO_0000740		
HGNC:438	biolink:Gene	ALPL (human)	A protein coding gene ALPL in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=438		
HGNC:437	biolink:Gene	ALPI (human)	A protein coding gene ALPI in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=437		
CHEBI:24020	biolink:ChemicalSubstance	fat-soluble vitamin (role)	Any vitamin that dissolves in fats and are stored in body tissues. Unlike the water-soluble vitamins, they are stored in the body for long periods of time and generally pose a greater risk for toxicity when consumed in excess.	PMID:33549284|PMID:34045883|PMID:32057251|PMID:31838543	hp.json	fat-soluble vitamin|fettloesliche Vitamine|fat-soluble vitamins	http://purl.obolibrary.org/obo/CHEBI_24020		3_STAR
HGNC:439	biolink:Gene	ALPP (human)	A protein coding gene ALPP in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=439		
HP:0008419	biolink:PhenotypicFeature	Intervertebral disc degeneration	The presence of degenerative changes of intervertebral disk.	MSH:D055959|SNOMEDCT_US:77547008|UMLS:C0158266	hp.json	Degenerative disc disease|Degenerative intervertebral disc|Degeneration of intervertebral disks|Degeneration of intervertebral discs|Degenerative intervertebral disk	http://purl.obolibrary.org/obo/HP_0008419		
HP:0008418	biolink:PhenotypicFeature	Squared-off platyspondyly		UMLS:C1849051	hp.json		http://purl.obolibrary.org/obo/HP_0008418		
HP:0008414	biolink:PhenotypicFeature	Lumbar kyphosis in infancy		UMLS:C1863423	hp.json	Hunched back in infancy|Round back in infancy	http://purl.obolibrary.org/obo/HP_0008414		
HP:0008417	biolink:PhenotypicFeature	Vertebral hypoplasia	Small, underdeveloped vertebral bodies.	UMLS:C0345394|SNOMEDCT_US:205456006	hp.json	Underdeveloped vertebrae	http://purl.obolibrary.org/obo/HP_0008417		hposlim_core
HP:0008416	biolink:PhenotypicFeature	Six lumbar vertebrae		UMLS:C1839279	hp.json		http://purl.obolibrary.org/obo/HP_0008416		
HP:0008410	biolink:PhenotypicFeature	Subungual hyperkeratotic fragments		UMLS:C1852311	hp.json		http://purl.obolibrary.org/obo/HP_0008410		
UBERON:0001611	biolink:AnatomicalEntity	sublingual artery	A branch of the lingual artery that supplies the sublingual gland.	MA:0002049|NCIT:C53002|EMAPA:37115|AAO:0010491|UMLS:C0226106|FMA:49543	hp.json	arteria sublingualis|sublingual branch of lingual artery	http://purl.obolibrary.org/obo/UBERON_0001611		human_reference_atlas|uberon_slim
UBERON:0001610	biolink:AnatomicalEntity	lingual artery	The lingual artery arises from the external carotid between the superior thyroid and facial artery[WP].	OpenCyc:Mx4rvfqDCZwpEbGdrcN5Y29ycA|MA:0001992|SCTID:181327002|UMLS:C0226104|FMA:49526|AAO:0010492|EMAPA:36324|Wikipedia:Lingual_artery|NCIT:C52961	hp.json	arteria lingualis|lingual branch of external carotid artery|arteria lingualis	http://purl.obolibrary.org/obo/UBERON_0001610		human_reference_atlas|uberon_slim
dcterms:license	biolink:NamedThing	license		http://purl.org/dc/terms/license	hp.json		http://purl.org/dc/terms/license		
HGNC:441	biolink:Gene	ALPG (human)	A protein coding gene ALPG in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=441		
HP:0008425	biolink:PhenotypicFeature	Cuboid-shaped thoracolumbar vertebral bodies		UMLS:C1855289	hp.json		http://purl.obolibrary.org/obo/HP_0008425		
HP:0008428	biolink:PhenotypicFeature	Vertebral clefting	Schisis (cleft or cleavage) of vertebral bodies.	UMLS:C1855828	hp.json	Vertebral clefts	http://purl.obolibrary.org/obo/HP_0008428		
HP:0008422	biolink:PhenotypicFeature	Vertebral wedging	An abnormal shape of the vertebral bodies whereby the vertebral bodies are thick on one side and taper to a thin edge at the other.	UMLS:C1695776	hp.json	Wedge-shaped vertebrae|anterior wedging|Wedged vertebrae	http://purl.obolibrary.org/obo/HP_0008422		
HP:0008421	biolink:PhenotypicFeature	Tall lumbar vertebral bodies		UMLS:C1863313	hp.json		http://purl.obolibrary.org/obo/HP_0008421		
UBERON:0001600	biolink:AnatomicalEntity	tensor tympani	The larger of the two muscles of the tympanic cavity, is contained in the bony canal above the osseous portion of the auditory tube. Its role is to dampen sounds produced from chewing. It arises from the cartilaginous portion of the auditory tube and the adjoining part of the great wing of the sphenoid, as well as from the osseous canal in which it is contained. Passing backward through the canal, it ends in a slender tendon which enters the tympanic cavity, makes a sharp bend around the extremity of the septum, known as the processus cochleariformis[1], and is inserted into the manubrium of the malleus, near its root[WP].	EMAPA:18587|UMLS:C0039529|GAID:166|MA:0001221|EHDAA:10167|EHDAA2:0002002|VHOG:0000698|MESH:D013719|NCIT:C33748|FMA:49028|EHDAA:10191	hp.json	M. tensor tympani|eustachian muscle|tensor tympani muscle|tympanic muscle|musculus tensor tympani	http://purl.obolibrary.org/obo/UBERON_0001600		uberon_slim
HP:0008424	biolink:PhenotypicFeature	Hypoplastic 5th lumbar vertebrae		UMLS:C1859366	hp.json	Underdeveloped 5th lumbar vertebrae	http://purl.obolibrary.org/obo/HP_0008424		
HP:0008423	biolink:PhenotypicFeature	Spinal dysplasia	The presence of developmental dysplasia of the vertebral column.	UMLS:C4021853	hp.json		http://purl.obolibrary.org/obo/HP_0008423		
HP:0008420	biolink:PhenotypicFeature	Punctate vertebral calcifications	The presence of punctiform calcification of the bone of the vertebral bodies.	UMLS:C4024678	hp.json		http://purl.obolibrary.org/obo/HP_0008420		
GO:1903867	biolink:BiologicalProcess	extraembryonic membrane development	The process whose specific outcome is the progression of an extraembryonic membrane over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_1903867		
GO:1901202	biolink:BiologicalProcess	negative regulation of extracellular matrix assembly	Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix assembly.		hp.json	down-regulation of extracellular matrix assembly|down regulation of extracellular matrix assembly|downregulation of extracellular matrix assembly|inhibition of extracellular matrix assembly	http://purl.obolibrary.org/obo/GO_1901202		
GO:1901203	biolink:BiologicalProcess	positive regulation of extracellular matrix assembly	Any process that activates or increases the frequency, rate or extent of extracellular matrix assembly.		hp.json	up regulation of extracellular matrix assembly|activation of extracellular matrix assembly|upregulation of extracellular matrix assembly|up-regulation of extracellular matrix assembly	http://purl.obolibrary.org/obo/GO_1901203		
GO:1901201	biolink:BiologicalProcess	regulation of extracellular matrix assembly	Any process that modulates the frequency, rate or extent of extracellular matrix assembly.		hp.json		http://purl.obolibrary.org/obo/GO_1901201		
PR:Q15848	biolink:Protein	adiponectin (human)	An adiponectin that is encoded in the genome of human.	UniProtKB:Q15848	hp.json	apM-1 (human)|ACDC|gelatin-binding protein (human)|adipocyte complement-related 30 kDa protein (human)|ACRP30|ADIPOQ|adipocyte, C1q and collagen domain-containing protein (human)|GBP28|adipose most abundant gene transcript 1 protein (human)|30 kDa adipocyte complement-related protein (human)|APM1|hADIPOQ	http://purl.obolibrary.org/obo/PR_Q15848		
GO:1901219	biolink:BiologicalProcess	regulation of cardiac chamber morphogenesis	Any process that modulates the frequency, rate or extent of cardiac chamber morphogenesis.		hp.json	regulation of heart chamber morphogenesis	http://purl.obolibrary.org/obo/GO_1901219		
GO:1901215	biolink:BiologicalProcess	negative regulation of neuron death	Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.		hp.json	down regulation of neuronal cell death|inhibition of neuron death|negative regulation of neuron cell death|down-regulation of neuron death|down-regulation of neuron cell death|inhibition of neuronal cell death|downregulation of neuronal cell death|down regulation of neuron cell death|inhibition of neuron cell death|downregulation of neuron cell death|downregulation of neuron death|negative regulation of neuronal cell death|down-regulation of neuronal cell death|down regulation of neuron death	http://purl.obolibrary.org/obo/GO_1901215		
GO:1901216	biolink:BiologicalProcess	positive regulation of neuron death	Any process that activates or increases the frequency, rate or extent of neuron death.		hp.json	upregulation of neuron cell death|upregulation of neuron death|up-regulation of neuronal cell death|up regulation of neuronal cell death|up regulation of neuron death|activation of neuronal cell death|up-regulation of neuron cell death|positive regulation of neuronal cell death|up-regulation of neuron death|up regulation of neuron cell death|activation of neuron death|upregulation of neuronal cell death|positive regulation of neuron cell death|activation of neuron cell death	http://purl.obolibrary.org/obo/GO_1901216		
GO:1901214	biolink:BiologicalProcess	regulation of neuron death	Any process that modulates the frequency, rate or extent of neuron death.		hp.json	regulation of neuronal cell death|regulation of neuron cell death	http://purl.obolibrary.org/obo/GO_1901214		
GO:1901211	biolink:BiologicalProcess	negative regulation of cardiac chamber formation	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber formation.		hp.json	downregulation of cardiac chamber formation|down regulation of heart chamber formation|downregulation of heart chamber formation|down-regulation of cardiac chamber formation|inhibition of heart chamber formation|down regulation of cardiac chamber formation|negative regulation of heart chamber formation|down-regulation of heart chamber formation|inhibition of cardiac chamber formation	http://purl.obolibrary.org/obo/GO_1901211		
GO:1901212	biolink:BiologicalProcess	positive regulation of cardiac chamber formation	Any process that activates or increases the frequency, rate or extent of cardiac chamber formation.		hp.json	up-regulation of cardiac chamber formation|up regulation of cardiac chamber formation|activation of cardiac chamber formation|up-regulation of heart chamber formation|up regulation of heart chamber formation|upregulation of cardiac chamber formation|positive regulation of heart chamber formation|upregulation of heart chamber formation|activation of heart chamber formation	http://purl.obolibrary.org/obo/GO_1901212		
GO:1901210	biolink:BiologicalProcess	regulation of cardiac chamber formation	Any process that modulates the frequency, rate or extent of cardiac chamber formation.		hp.json	regulation of heart chamber formation	http://purl.obolibrary.org/obo/GO_1901210		
GO:1901220	biolink:BiologicalProcess	negative regulation of cardiac chamber morphogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac chamber morphogenesis.		hp.json	downregulation of heart chamber morphogenesis|inhibition of heart chamber morphogenesis|down-regulation of cardiac chamber morphogenesis|down regulation of cardiac chamber morphogenesis|negative regulation of heart chamber morphogenesis|down-regulation of heart chamber morphogenesis|downregulation of cardiac chamber morphogenesis|inhibition of cardiac chamber morphogenesis|down regulation of heart chamber morphogenesis	http://purl.obolibrary.org/obo/GO_1901220		
GO:1901221	biolink:BiologicalProcess	positive regulation of cardiac chamber morphogenesis	Any process that activates or increases the frequency, rate or extent of cardiac chamber morphogenesis.		hp.json	up regulation of cardiac chamber morphogenesis|activation of cardiac chamber morphogenesis|up-regulation of heart chamber morphogenesis|up regulation of heart chamber morphogenesis|activation of heart chamber morphogenesis|upregulation of cardiac chamber morphogenesis|positive regulation of heart chamber morphogenesis|upregulation of heart chamber morphogenesis|up-regulation of cardiac chamber morphogenesis	http://purl.obolibrary.org/obo/GO_1901221		
GO:0009084	biolink:BiologicalProcess	glutamine family amino acid biosynthetic process	The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.		hp.json	glutamine family amino acid synthesis|glutamine family amino acid formation|glutamine family amino acid anabolism|glutamine family amino acid biosynthesis	http://purl.obolibrary.org/obo/GO_0009084		
GO:0009081	biolink:BiologicalProcess	branched-chain amino acid metabolic process	The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.		hp.json	branched chain family amino acid metabolism	http://purl.obolibrary.org/obo/GO_0009081		
GO:0061695	biolink:CellularComponent	transferase complex, transferring phosphorus-containing groups	A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).		hp.json		http://purl.obolibrary.org/obo/GO_0061695		
GO:0061696	biolink:CellularComponent	pituitary gonadotropin complex	A protein complex that is a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. capable of regulating normal growth, sexual development, and reproductive function.		hp.json		http://purl.obolibrary.org/obo/GO_0061696		
GO:0010070	biolink:BiologicalProcess	zygote asymmetric cell division	The division of the zygote into two daughter cells that will adopt developmentally distinct potentials.		hp.json	zygote asymmetric cytokinesis	http://purl.obolibrary.org/obo/GO_0010070		
GO:0022032	biolink:BiologicalProcess	telencephalon oligodendrocyte cell migration	The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0022032		
UBERON:0035083	biolink:AnatomicalEntity	transverse process-bearing vertebra	A vertebra that has a transverse process.		hp.json	pygal vertebra|TP vertebra	http://purl.obolibrary.org/obo/UBERON_0035083		
GO:0022035	biolink:BiologicalProcess	rhombomere cell migration	The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere.		hp.json		http://purl.obolibrary.org/obo/GO_0022035		
GO:0022037	biolink:BiologicalProcess	metencephalon development	The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0022037		
GO:1901248	biolink:BiologicalProcess	positive regulation of lung ciliated cell differentiation	Any process that activates or increases the frequency, rate or extent of lung ciliated cell differentiation.		hp.json	upregulation of lung ciliated cell differentiation|up regulation of lung ciliated cell differentiation|up-regulation of lung ciliated cell differentiation|activation of lung ciliated cell differentiation	http://purl.obolibrary.org/obo/GO_1901248		
GO:1901246	biolink:BiologicalProcess	regulation of lung ciliated cell differentiation	Any process that modulates the frequency, rate or extent of lung ciliated cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_1901246		
GO:1901247	biolink:BiologicalProcess	negative regulation of lung ciliated cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of lung ciliated cell differentiation.		hp.json	down-regulation of lung ciliated cell differentiation|downregulation of lung ciliated cell differentiation|down regulation of lung ciliated cell differentiation|inhibition of lung ciliated cell differentiation	http://purl.obolibrary.org/obo/GO_1901247		
GO:0009059	biolink:BiologicalProcess	macromolecule biosynthetic process	The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.		hp.json	macromolecule synthesis|macromolecule formation|biopolymer biosynthetic process|macromolecule biosynthesis|macromolecule anabolism	http://purl.obolibrary.org/obo/GO_0009059		goslim_pir
GO:0009058	biolink:BiologicalProcess	biosynthetic process	The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.	Wikipedia:Anabolism	hp.json	anabolism|multicellular organismal biosynthetic process|formation|synthesis|single-organism biosynthetic process|biosynthesis	http://purl.obolibrary.org/obo/GO_0009058		goslim_plant|goslim_chembl|goslim_metagenomics
GO:0009057	biolink:NamedThing	macromolecule catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0009057		
GO:0009056	biolink:BiologicalProcess	catabolic process	The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.	Wikipedia:Catabolism	hp.json	degradation|breakdown|single-organism catabolic process|catabolism|multicellular organismal catabolic process	http://purl.obolibrary.org/obo/GO_0009056		goslim_plant|goslim_chembl|goslim_agr
GO:0022030	biolink:BiologicalProcess	telencephalon glial cell migration	The orderly movement of glial cells through the telencephalon.		hp.json		http://purl.obolibrary.org/obo/GO_0022030		
GO:0009064	biolink:BiologicalProcess	glutamine family amino acid metabolic process	The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.		hp.json	glutamine family amino acid metabolism	http://purl.obolibrary.org/obo/GO_0009064		
UBERON:0035091	biolink:AnatomicalEntity	extrinsic post-anal tail muscle	A post-anal tail that attaches outside the tail.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035091		
UBERON:0035096	biolink:AnatomicalEntity	fascia of tail			hp.json		http://purl.obolibrary.org/obo/UBERON_0035096		
UBERON:0035097	biolink:AnatomicalEntity	iliocaudalis muscle	A muscle that attaches to the iliac crest and to a caudal vertebra.		hp.json	iliocaudalis|M. iliocaudalis	http://purl.obolibrary.org/obo/UBERON_0035097		
GO:0009069	biolink:BiologicalProcess	serine family amino acid metabolic process	The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.		hp.json	serine family amino acid metabolism	http://purl.obolibrary.org/obo/GO_0009069		
GO:0009066	biolink:BiologicalProcess	aspartate family amino acid metabolic process	The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.		hp.json	aspartate family amino acid metabolism	http://purl.obolibrary.org/obo/GO_0009066		
GO:0009072	biolink:BiologicalProcess	aromatic amino acid family metabolic process	The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).		hp.json	aromatic amino acid family metabolism	http://purl.obolibrary.org/obo/GO_0009072		
GO:0022029	biolink:BiologicalProcess	telencephalon cell migration	The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.		hp.json		http://purl.obolibrary.org/obo/GO_0022029		
GO:0022010	biolink:BiologicalProcess	central nervous system myelination	The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.		hp.json	myelination in central nervous system	http://purl.obolibrary.org/obo/GO_0022010		
GO:0022011	biolink:BiologicalProcess	myelination in peripheral nervous system	The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.		hp.json	peripheral nervous system myelination	http://purl.obolibrary.org/obo/GO_0022011		
GO:1901264	biolink:BiologicalProcess	carbohydrate derivative transport	The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_1901264		
HGNC:399	biolink:Gene	ALB (human)	A protein coding gene ALB in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=399		
GO:0010039	biolink:BiologicalProcess	response to iron ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.		hp.json	response to iron	http://purl.obolibrary.org/obo/GO_0010039		
GO:0010032	biolink:BiologicalProcess	meiotic chromosome condensation	Compaction of chromatin structure prior to meiosis in eukaryotic cells.		hp.json	chromosome condensation involved in meiotic cell cycle	http://purl.obolibrary.org/obo/GO_0010032		
GO:0010033	biolink:BiologicalProcess	response to organic substance	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.		hp.json	process resulting in tolerance to organic substance	http://purl.obolibrary.org/obo/GO_0010033		
GO:0010035	biolink:BiologicalProcess	response to inorganic substance	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0010035		
GO:0010038	biolink:BiologicalProcess	response to metal ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.		hp.json	response to metal|response to heavy metal|heavy metal sensitivity/resistance	http://purl.obolibrary.org/obo/GO_0010038		
GO:0022008	biolink:BiologicalProcess	neurogenesis	Generation of cells within the nervous system.	Wikipedia:Neurogenesis	hp.json	neural cell differentiation|nervous system cell generation	http://purl.obolibrary.org/obo/GO_0022008		
GO:0022009	biolink:BiologicalProcess	central nervous system vasculogenesis	The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.		hp.json		http://purl.obolibrary.org/obo/GO_0022009		
UBERON:0035045	biolink:AnatomicalEntity	parotid gland intralobular duct	Any of the tubular canals of the parotid gland located within the parenchymal (secretory) tissue i.e. within lobules; both intercalated and striated (secretory) ducts are intralobular ducts.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035045		
CHEBI:63571	biolink:ChemicalSubstance	trisaccharide derivative	An oligosaccharide derivative that is formally obtained from a trisaccharide.		hp.json	trisaccharide derivatives	http://purl.obolibrary.org/obo/CHEBI_63571		3_STAR
UBERON:0035049	biolink:AnatomicalEntity	excretory duct of salivary gland	Any of the interlobular excretory ducts of a salivary gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts[MP,generalized].	FMA:60052	hp.json		http://purl.obolibrary.org/obo/UBERON_0035049		
UBERON:0035048	biolink:AnatomicalEntity	parotid gland excretory duct	Any of the interlobular excretory ducts of the parotid gland which are found in the connective tissue septa and formed by the union of several intralobular striated (secretory) ducts; ultimately, the excretory ducts of the parotid gland coalesce and form a single main excretory duct (Stensen's duct) that opens into the oral cavity; excretory ducts do not change the secretory product.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035048		
GO:0048628	biolink:BiologicalProcess	myoblast maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast to attain its fully functional state. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.		hp.json		http://purl.obolibrary.org/obo/GO_0048628		
GO:0048627	biolink:BiologicalProcess	myoblast development	The process whose specific outcome is the progression of the myoblast over time, from its formation to the mature structure. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.		hp.json		http://purl.obolibrary.org/obo/GO_0048627		
UBERON:0035050	biolink:AnatomicalEntity	excretory duct			hp.json		http://purl.obolibrary.org/obo/UBERON_0035050		
HP:0430009	biolink:PhenotypicFeature	Hypoplasia of eyelid	Developmental hypoplasia of the eyelid.	UMLS:C4280274|SNOMEDCT_US:204203001|UMLS:C0344499	hp.json	Hypoplasia of the eyelid|Decreased size of eyelid|Small eyelid|Underdevelopment of eyelid|Short eyelid|Hypoplastic eyelid	http://purl.obolibrary.org/obo/HP_0430009		
HP:0430008	biolink:PhenotypicFeature	Accessory eyelid	The presence of more than the normal number of eyelids.	UMLS:C4280275|SNOMEDCT_US:24606006|UMLS:C0266576	hp.json	Double eyelid|Extra eyelid	http://purl.obolibrary.org/obo/HP_0430008		
UBERON:0035053	biolink:AnatomicalEntity	interlobular duct of salivary gland		FMA:60053	hp.json		http://purl.obolibrary.org/obo/UBERON_0035053		
GO:0048636	biolink:BiologicalProcess	positive regulation of muscle organ development	Any process that activates, maintains or increases the rate of muscle development.		hp.json	up regulation of muscle development|stimulation of muscle development|up-regulation of muscle development|activation of muscle development|upregulation of muscle development	http://purl.obolibrary.org/obo/GO_0048636		
GO:0048635	biolink:BiologicalProcess	negative regulation of muscle organ development	Any process that stops, prevents, or reduces the frequency, rate or extent of muscle development.		hp.json	downregulation of muscle development|down regulation of muscle development|inhibition of muscle development|down-regulation of muscle development	http://purl.obolibrary.org/obo/GO_0048635		
GO:0048634	biolink:BiologicalProcess	regulation of muscle organ development	Any process that modulates the frequency, rate or extent of muscle development.		hp.json		http://purl.obolibrary.org/obo/GO_0048634		
GO:0048633	biolink:BiologicalProcess	positive regulation of skeletal muscle tissue growth	Any process that activates, maintains or increases the rate of skeletal muscle growth.		hp.json	up-regulation of skeletal muscle growth|activation of skeletal muscle growth|upregulation of skeletal muscle growth|up regulation of skeletal muscle growth|stimulation of skeletal muscle growth	http://purl.obolibrary.org/obo/GO_0048633		
GO:0048632	biolink:BiologicalProcess	negative regulation of skeletal muscle tissue growth	Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle growth.		hp.json	downregulation of skeletal muscle growth|down regulation of skeletal muscle growth|inhibition of skeletal muscle growth|down-regulation of skeletal muscle growth	http://purl.obolibrary.org/obo/GO_0048632		
GO:0048631	biolink:BiologicalProcess	regulation of skeletal muscle tissue growth	Any process that modulates the frequency, rate or extent of skeletal muscle growth.		hp.json		http://purl.obolibrary.org/obo/GO_0048631		
GO:0048630	biolink:BiologicalProcess	skeletal muscle tissue growth	The increase in size or mass of a skeletal muscle. This may be due to a change in the fiber number or size.		hp.json		http://purl.obolibrary.org/obo/GO_0048630		
GO:0048639	biolink:BiologicalProcess	positive regulation of developmental growth	Any process that activates, maintains or increases the rate of developmental growth.		hp.json	up-regulation of developmental growth|activation of developmental growth|upregulation of developmental growth|up regulation of developmental growth|stimulation of developmental growth	http://purl.obolibrary.org/obo/GO_0048639		
GO:0048638	biolink:BiologicalProcess	regulation of developmental growth	Any process that modulates the frequency, rate or extent of developmental growth.		hp.json		http://purl.obolibrary.org/obo/GO_0048638		
HP:0430007	biolink:PhenotypicFeature	Symblepharon	A partial or complete adhesion of the palpebral conjunctiva of the eyelid to the bulbar conjunctiva of the eyeball.	UMLS:C0152454|SNOMEDCT_US:90216006	hp.json	Eyelid stuck to eyeball|Eyelid adhesion to globe of eye	http://purl.obolibrary.org/obo/HP_0430007		
HP:0430006	biolink:PhenotypicFeature	Ectopic cilia of eyelid	An eyelash that emerges from the underside (conjunctiva) of the upper or lower eyelid.	SNOMEDCT_US:95504004|UMLS:C0521574	hp.json		http://purl.obolibrary.org/obo/HP_0430006		
HP:0430005	biolink:PhenotypicFeature	Abnormal ethmoid bone morphology	An abnormality of the ethmoid bone	UMLS:C4021869	hp.json	Malformation of the ethmoid bone|Deformity of the ethmoid bone|Abnormality of ethmoid bone|Anomaly of the ethmoid bone	http://purl.obolibrary.org/obo/HP_0430005		
HP:0430004	biolink:PhenotypicFeature	Frontomalar faciosynostosis		UMLS:C4021870	hp.json		http://purl.obolibrary.org/obo/HP_0430004		
HP:0430003	biolink:PhenotypicFeature	Abnormal palatine bone morphology	An abnormality of the palatine bone.	UMLS:C4021871	hp.json	Malformation of the palatine bone|Deformity of the palatine bone|Anomaly of the palatine bone|Abnormality of the palatine bone	http://purl.obolibrary.org/obo/HP_0430003		
HP:0430002	biolink:PhenotypicFeature	Abnormal lacrimal bone morphology	An abnormality of the lacrimal bone.	UMLS:C4021872	hp.json	Deformity of the lacrimal bone|Malformation of the lacrimal bone|Anomaly of the lacrimal bone	http://purl.obolibrary.org/obo/HP_0430002		
HP:0430000	biolink:PhenotypicFeature	Abnormal frontal bone morphology	An abnormality of the frontal bone.	UMLS:C4021873	hp.json	Abnormal morphology of frontal bone|Abnormality of the frontal bone|Abnormality of the bone of the forehead|Anomaly of the frontal bone|Malformation of the frontal bone|Deformity of the frontal bone	http://purl.obolibrary.org/obo/HP_0430000		
GO:0048640	biolink:BiologicalProcess	negative regulation of developmental growth	Any process that stops, prevents, or reduces the frequency, rate or extent of developmental growth.		hp.json	down regulation of developmental growth|inhibition of developmental growth|down-regulation of developmental growth|downregulation of developmental growth	http://purl.obolibrary.org/obo/GO_0048640		
UBERON:0011050	biolink:AnatomicalEntity	thoracic vertebra 8	The eighth thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	FMA:9991|UMLS:C0459953|EMAPA:19549|MA:0001445|NCIT:C33730	hp.json	eighth dorsal vertebra|T8 vertebra|eighth thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0011050		
GO:0048646	biolink:BiologicalProcess	anatomical structure formation involved in morphogenesis	The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.		hp.json	formation of an anatomical structure involved in morphogenesis	http://purl.obolibrary.org/obo/GO_0048646		goslim_chembl
GO:0048645	biolink:BiologicalProcess	animal organ formation	The process pertaining to the initial formation of an animal organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment. Organs are a natural part or structure in an animal or a plant, capable of performing some special action (termed its function), which is essential to the life or well-being of the whole. The heart and lungs are organs of animals, and the petal and leaf are organs of plants. In animals the organs are generally made up of several tissues, one of which usually predominates, and determines the principal function of the organ.		hp.json	initiation of an animal organ primordium|animal organ primordium initiation	http://purl.obolibrary.org/obo/GO_0048645		
GO:0048644	biolink:BiologicalProcess	muscle organ morphogenesis	The process in which the anatomical structures of muscle are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0048644		
GO:0048643	biolink:BiologicalProcess	positive regulation of skeletal muscle tissue development	Any process that activates, maintains or increases the rate of skeletal muscle tissue development.		hp.json	up-regulation of skeletal muscle development|up regulation of skeletal muscle development|activation of skeletal muscle development|stimulation of skeletal muscle development|upregulation of skeletal muscle development	http://purl.obolibrary.org/obo/GO_0048643		
GO:0048642	biolink:BiologicalProcess	negative regulation of skeletal muscle tissue development	Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle tissue development.		hp.json	down regulation of skeletal muscle development|inhibition of skeletal muscle development|downregulation of skeletal muscle development|down-regulation of skeletal muscle development	http://purl.obolibrary.org/obo/GO_0048642		
GO:0048641	biolink:BiologicalProcess	regulation of skeletal muscle tissue development	Any process that modulates the frequency, rate or extent of skeletal muscle tissue development.		hp.json		http://purl.obolibrary.org/obo/GO_0048641		
GO:0061626	biolink:BiologicalProcess	pharyngeal arch artery morphogenesis	The process in which the anatomical structures of a pharyngeal arch artery is generated and organized. The pharyngeal arch arteries are a series of six paired embryological vascular structures, the development of which give rise to several major arteries, such as the stapedial artery, the middle meningeal artery, the internal carotid artery and the pulmonary artery.		hp.json	aortic arch artery morphogenesis	http://purl.obolibrary.org/obo/GO_0061626		
GO:0061629	biolink:MolecularActivity	RNA polymerase II-specific DNA-binding transcription factor binding	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.		hp.json	RNA polymerase II activating transcription factor binding|RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding|RNA polymerase II sequence-specific DNA binding transcription factor binding|RNA polymerase II sequence-specific DNA-binding transcription factor binding	http://purl.obolibrary.org/obo/GO_0061629		
UBERON:0035074	biolink:AnatomicalEntity	duct of apocrine sweat gland		FMA:70643	hp.json	ductal part of apocrine sweat gland	http://purl.obolibrary.org/obo/UBERON_0035074		
UBERON:0035073	biolink:AnatomicalEntity	duct of eccrine sweat gland		FMA:70617	hp.json	ductal part of eccrine sweat gland	http://purl.obolibrary.org/obo/UBERON_0035073		
UBERON:0035075	biolink:AnatomicalEntity	thymus subunit		FMA:71193	hp.json	lobe or lobule of thymus	http://purl.obolibrary.org/obo/UBERON_0035075		
GO:0048659	biolink:BiologicalProcess	smooth muscle cell proliferation	The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.		hp.json	SMC proliferation	http://purl.obolibrary.org/obo/GO_0048659		
UBERON:0035078	biolink:AnatomicalEntity	parotid gland interlobular duct	Any of the excretory ducts of the parotid gland which are found in the connective tissue septa i.e. between lobules.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035078		
PR:000049996	biolink:Protein	active alpha-amylase isozyme (human)	An active alpha-amylase isozyme that is encoded in the genome of human.		hp.json	fam:hAMY	http://purl.obolibrary.org/obo/PR_000049996		
PR:000049995	biolink:Protein	active alpha-amylase isozyme	A protein that has alpha-amylase activity.		hp.json	fam:AMY	http://purl.obolibrary.org/obo/PR_000049995		
GO:0048662	biolink:BiologicalProcess	negative regulation of smooth muscle cell proliferation	Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.		hp.json	down regulation of smooth muscle cell proliferation|inhibition of smooth muscle cell proliferation|down-regulation of smooth muscle cell proliferation|negative regulation of SMC proliferation|downregulation of smooth muscle cell proliferation	http://purl.obolibrary.org/obo/GO_0048662		
GO:0048661	biolink:BiologicalProcess	positive regulation of smooth muscle cell proliferation	Any process that activates or increases the rate or extent of smooth muscle cell proliferation.		hp.json	positive regulation of SMC proliferation|upregulation of smooth muscle cell proliferation|up regulation of smooth muscle cell proliferation|stimulation of smooth muscle cell proliferation|up-regulation of smooth muscle cell proliferation|activation of smooth muscle cell proliferation	http://purl.obolibrary.org/obo/GO_0048661		
GO:1903829	biolink:BiologicalProcess	positive regulation of protein localization	Any process that activates or increases the frequency, rate or extent of a protein localization.		hp.json	up-regulation of cellular protein localisation|upregulation of cellular protein localization|up regulation of cellular protein localisation|positive regulation of cellular protein localisation|up-regulation of cellular protein localization|upregulation of cellular protein localisation|up regulation of cellular protein localization|positive regulation of cellular protein localization	http://purl.obolibrary.org/obo/GO_1903829		
GO:0048660	biolink:BiologicalProcess	regulation of smooth muscle cell proliferation	Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.		hp.json	regulation of SMC proliferation	http://purl.obolibrary.org/obo/GO_0048660		
HP:0033361	biolink:PhenotypicFeature	Nasal ulcer	An open sore of the nasal mucosa.		hp.json		http://purl.obolibrary.org/obo/HP_0033361		
HP:0033360	biolink:PhenotypicFeature	Impaired ability to shift attention	A behavioral abnormality whereby a person is unable to move freely from one situation, activity or aspect of aa problem to another as circumstances demand. Key aspects of shifting include the ability to make transitions, problem solve flexibly, switch or alternate attention, and change focus from one mind-set or topic to another. Mild deficits in the ability to shift compromise the efficiency of problem solving, whereas more severe difficulties are reflected in perseverative behaviors. Sometimes this is described as being rigid or inflexible.		hp.json	Impaired task shifting	http://purl.obolibrary.org/obo/HP_0033360		
GO:1903828	biolink:BiologicalProcess	negative regulation of protein localization	Any process that stops, prevents or reduces the frequency, rate or extent of a protein localization.		hp.json	inhibition of cellular protein localisation|down-regulation of cellular protein localization|downregulation of cellular protein localisation|negative regulation of cellular protein localization|down regulation of cellular protein localization|inhibition of cellular protein localization|downregulation of cellular protein localization|negative regulation of cellular protein localisation|down-regulation of cellular protein localisation|down regulation of cellular protein localisation	http://purl.obolibrary.org/obo/GO_1903828		
GO:1903825	biolink:BiologicalProcess	organic acid transmembrane transport	The process in which an organic acid is transported across a membrane.		hp.json		http://purl.obolibrary.org/obo/GO_1903825		
HP:0033367	biolink:PhenotypicFeature	Orthodeoxia	Low level of blood oxygen induced by changing from a recumbent to an upright position.		hp.json		http://purl.obolibrary.org/obo/HP_0033367		
HP:0033366	biolink:PhenotypicFeature	Exogenous lipoid pneumonia	A type of lipoid pneumonia in which the source of the lipids is external to the body.		hp.json		http://purl.obolibrary.org/obo/HP_0033366		
GO:0046005	biolink:BiologicalProcess	positive regulation of circadian sleep/wake cycle, REM sleep	Any process that activates or increases the duration or quality of rapid eye movement (REM) sleep.		hp.json	up-regulation of circadian sleep/wake cycle, REM sleep|up regulation of circadian sleep/wake cycle, REM sleep|activation of circadian sleep/wake cycle, REM sleep|stimulation of circadian sleep/wake cycle, REM sleep|upregulation of circadian sleep/wake cycle, REM sleep|positive regulation of REM sleep	http://purl.obolibrary.org/obo/GO_0046005		
HP:0033369	biolink:PhenotypicFeature	Cavitating leukodystrophy	A type of leukodystrophy characterized by multiple small cavitations typically in the periventricular and deep cerebral white matter. The cavitations are visible as a central cavity with cerebrospinal fluid-like signal intensity.		hp.json		http://purl.obolibrary.org/obo/HP_0033369		
GO:0048667	biolink:BiologicalProcess	cell morphogenesis involved in neuron differentiation	The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.		hp.json	neuron morphogenesis involved in differentiation	http://purl.obolibrary.org/obo/GO_0048667		
HP:0033368	biolink:PhenotypicFeature	Platypnea	A type of dyspnea that occurs when the affected person changes from a recumbent to an upright position.		hp.json		http://purl.obolibrary.org/obo/HP_0033368		
GO:0048666	biolink:BiologicalProcess	neuron development	The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0048666		
HP:0033363	biolink:PhenotypicFeature	Hyaline membranes	Hyaline membranes are homogeneous eosinophilic material composed of cellular debris, plasma proteins, and surfactant plastered against alveolar ducts and alveolar walls. The hyaline membranes are deposited along the walls of the alveoli, where gas exchange typically occurs, thereby making gas exchange difficult.		hp.json		http://purl.obolibrary.org/obo/HP_0033363		
UBERON:0035005	biolink:AnatomicalEntity	preputial swelling of male		EMAPA:29220	hp.json	prepuce of male	http://purl.obolibrary.org/obo/UBERON_0035005		
HP:0033362	biolink:PhenotypicFeature	Recurrent coughing spasms	Repeated occurrence of episodes of coughing, with each episode consisting of at least five minutes of continuous coughing.		hp.json		http://purl.obolibrary.org/obo/HP_0033362		
UBERON:0035004	biolink:AnatomicalEntity	preputial swelling		EMAPA:35702	hp.json		http://purl.obolibrary.org/obo/UBERON_0035004		
HP:0033365	biolink:PhenotypicFeature	Endogenous lipoid pneumonia	A type of lipoid pneumonia in which the source of the lipids is the body itself. When an airway is obstructed, it is often the case that distal to the obstruction, lipid-laden macrophages and giant cells fill the lumen of the disconnected airspace.		hp.json		http://purl.obolibrary.org/obo/HP_0033365		
HP:0033364	biolink:PhenotypicFeature	Lipoid pneumonia	A specific form of lung inflammation that results from accumulation of lipids in the alveoli. Lipoid pneumonia can be either exogenous or endogenous in cause based on the source of the lipid.		hp.json		http://purl.obolibrary.org/obo/HP_0033364		
UBERON:0035006	biolink:AnatomicalEntity	preputial swelling of female		EMAPA:30478	hp.json	prepuce of female	http://purl.obolibrary.org/obo/UBERON_0035006		
CL:1001588	biolink:Cell	colon glandular cell	Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells.	CALOHA:TS-1274	hp.json	colon glandular cells	http://purl.obolibrary.org/obo/CL_1001588		
GO:0034097	biolink:BiologicalProcess	response to cytokine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.		hp.json	response to cytokine stimulus	http://purl.obolibrary.org/obo/GO_0034097		
HP:0033370	biolink:PhenotypicFeature	Bronchial telangiectasia	Telangiectasias (small dilated blood vessels located near the surface of the skin or mucous membranes) located in the trachoebronchial system.		hp.json	Endobronchial telangiectasia	http://purl.obolibrary.org/obo/HP_0033370		
HP:0033372	biolink:PhenotypicFeature	Abnormal KCO	Any deviation from the normal range of KCO. The KCO is a measurement of the rate constant for alveolar uptake of CO during breath-holding in the single breath measurement of DLCO at full inflation. The DLCO is derived as the product of the KCO and the single breath alveolar volume (VA) divided by PB-PH2O.		hp.json		http://purl.obolibrary.org/obo/HP_0033372		
HP:0033371	biolink:PhenotypicFeature	Bronchocentric granulomatosis	Granulomatous inflammation that surrounds the bronchi and bronchioles, replacing bronchial walls and mucosa. In bronchocentric granulomatosis, the lumen of the airway contains necrotic debris, and palisaded histiocytes surround the lumen.		hp.json		http://purl.obolibrary.org/obo/HP_0033371		
HP:0033378	biolink:PhenotypicFeature	Increased airway neuroepithelial bodies	Presence of increased numbers of bombesin-immuno-positive neuroendocrine cell cluster (neuroepithelial bodies) in the alveolar ducts.		hp.json		http://purl.obolibrary.org/obo/HP_0033378		
HP:0033377	biolink:PhenotypicFeature	Increased airway neuroendocrine cells	Presence of increased numbers of bombesin-immuno-positive neuroendocrine cells (NECs) within distal airways. There are no formal criteria for an increase (which is also dependend on the sensitivity of the staining method), findings of neuroendocrine cells in at least 70% of bronchioles by lung biopsy and at least 10% NECs in an individual airway are consistent with the diagnosis of Neuroendocrine cell hyperplasia of infancy in the appropriate clinical setting. Increases are also seen in other clicnial settings. Neuroendocrine neoplasms of the lung encompass NE tumors (NETs), which split into typical and atypical carcinoids, and NE carcinomas (NECs).		hp.json		http://purl.obolibrary.org/obo/HP_0033377		
GO:1903831	biolink:BiologicalProcess	signal transduction involved in cellular response to ammonium ion	Any signal transduction that is involved in cellular response to ammonium ion.		hp.json	signalling cascade involved in cellular response to ammonium ion|signaling cascade involved in cellular response to ammonium ion|signalling pathway involved in cellular response to ammonium ion|signaling pathway involved in cellular response to ammonium ion	http://purl.obolibrary.org/obo/GO_1903831		
HP:0033379	biolink:PhenotypicFeature	Bilateral superior vena cava	The presence of a left and a right superior vena cava.		hp.json	Bilateral SVC	http://purl.obolibrary.org/obo/HP_0033379		
GO:0046014	biolink:BiologicalProcess	negative regulation of T cell homeostatic proliferation	Any process that stops, prevents or reduces the rate or extent of resting T cell proliferation.		hp.json	negative regulation of T-lymphocyte homeostatic proliferation|downregulation of T cell homeostatic proliferation|negative regulation of resting T cell proliferation|down regulation of T cell homeostatic proliferation|inhibition of T cell homeostatic proliferation|down-regulation of T cell homeostatic proliferation|negative regulation of T-cell homeostatic proliferation|negative regulation of T lymphocyte homeostatic proliferation	http://purl.obolibrary.org/obo/GO_0046014		
HP:0033374	biolink:PhenotypicFeature	Decreased KCO	Decreased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index).		hp.json		http://purl.obolibrary.org/obo/HP_0033374		
HP:0033373	biolink:PhenotypicFeature	Increased KCO	Increased diffusion capacity of the lung for carbon monoxide (CO) rate constant (efficiency index).		hp.json		http://purl.obolibrary.org/obo/HP_0033373		
HP:0033376	biolink:PhenotypicFeature	Alveolar septal thickening	Increased width of the alveolar septum, which is the structure that separates neighboring alveoli. This finding can be appreciated on histology.		hp.json		http://purl.obolibrary.org/obo/HP_0033376		
CL:1001579	biolink:Cell	cerebral cortex glial cell	Glial cell of cerebral cortex.	CALOHA:TS-1256	hp.json	cerebral cortex glial cells|cerebrum cortex glial cell|brain cortex glial cell	http://purl.obolibrary.org/obo/CL_1001579		
GO:0046013	biolink:BiologicalProcess	regulation of T cell homeostatic proliferation	Any process that modulates the frequency, rate or extent of resting T cell proliferation.		hp.json	regulation of resting T cell proliferation|regulation of T-cell homeostatic proliferation|regulation of T lymphocyte homeostatic proliferation|regulation of T-lymphocyte homeostatic proliferation	http://purl.obolibrary.org/obo/GO_0046013		
HP:0033375	biolink:PhenotypicFeature	Anthracosis	Anthracosis is the deposition of black carbon pigment. It is commonly seen in perihilar lymph nodes as well as within lung parenchyma. There can be prominent storiforming (i.e., spiral patterning) of histiocytes, to such an extent as to mimic a neoplastic lesion histologically. Anthracosis is a common finding in smokers and polluted city dwellers.		hp.json		http://purl.obolibrary.org/obo/HP_0033375		
CL:1001576	biolink:Cell	oral mucosa squamous cell	Squamous cell of oral epithelium.	CALOHA:TS-1252	hp.json	oral mucosa squamous epithelial cell|oral cavity mucosa squamous epithelial cell|oral mucosa squamous epithelial cells|oral cavity mucosa squamous cell	http://purl.obolibrary.org/obo/CL_1001576		
CL:1001572	biolink:Cell	colon endothelial cell	A vascular endothelial cell found in colon blood vessels.	CALOHA:TS-2397	hp.json	colon endothelial cells|colonic endothelial cell	http://purl.obolibrary.org/obo/CL_1001572		
UBERON:0011092	biolink:AnatomicalEntity	right pelvic girdle region	A pelvic girdle region that is in the right side of a multicellular organism.	FMA:16582	hp.json	right pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0011092		
HP:0033381	biolink:PhenotypicFeature	Elevated circulating stearoylcarnitine concentration	Abnormally increased concentration of O-stearoylcarnitine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033381		
UBERON:0011091	biolink:AnatomicalEntity	skeleton of left pelvic girdle	A skeleton of pelvic girdle that is part of a left pelvic girdle region.	FMA:87594	hp.json		http://purl.obolibrary.org/obo/UBERON_0011091		
HP:0033380	biolink:PhenotypicFeature	Nasal chondritis	Inflammation of the cartilage of the nose.		hp.json	Nose chondritis	http://purl.obolibrary.org/obo/HP_0033380		
UBERON:0011090	biolink:AnatomicalEntity	skeleton of right pelvic girdle	A skeleton of pelvic girdle that is part of a right pelvic girdle region.	FMA:87593	hp.json		http://purl.obolibrary.org/obo/UBERON_0011090		
HP:0033383	biolink:PhenotypicFeature	Decreased compound muscle action potential amplitude	Reduced level of the compound muscle action potential (CMAP), which is recorded following electrical stimulation of a nerve from surface electrodes overlying a muscle supplied by that nerve.		hp.json	Decreased CMAP amplitude	http://purl.obolibrary.org/obo/HP_0033383		
HP:0033382	biolink:PhenotypicFeature	Elevated circulating palmitoylcarnitine concentration	Abnormally increased concentration of palmitoylcarnitine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033382		
UBERON:0011096	biolink:AnatomicalEntity	lacrimal nerve	The lacrimal nerve is the smallest of the three branches of the ophthalmic division of the trigeminal nerve.	FMA:52628|NCIT:C32908	hp.json	nervus lacrimalis	http://purl.obolibrary.org/obo/UBERON_0011096		
GO:1903849	biolink:BiologicalProcess	positive regulation of aorta morphogenesis	Any process that activates or increases the frequency, rate or extent of aorta morphogenesis.		hp.json	up regulation of aorta morphogenesis|activation of aorta morphogenesis|upregulation of aorta morphogenesis|up-regulation of aorta morphogenesis	http://purl.obolibrary.org/obo/GO_1903849		
GO:1903848	biolink:BiologicalProcess	negative regulation of aorta morphogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of aorta morphogenesis.		hp.json	down-regulation of aorta morphogenesis|down regulation of aorta morphogenesis|inhibition of aorta morphogenesis|downregulation of aorta morphogenesis	http://purl.obolibrary.org/obo/GO_1903848		
UBERON:0011095	biolink:AnatomicalEntity	vertebra pre-cartilage condensation	The pre-cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.	EMAPA:32671|VHOG:0000582	hp.json	vertebral pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0011095		
UBERON:0035021	biolink:AnatomicalEntity	right vagus X nerve trunk		EMAPA:37799|MA:0001152|FMA:18151	hp.json	right vagus neural trunk|trunk of right vagus|posterior vagus X nerve trunk	http://purl.obolibrary.org/obo/UBERON_0035021		
GO:1903847	biolink:BiologicalProcess	regulation of aorta morphogenesis	Any process that modulates the frequency, rate or extent of aorta morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_1903847		
UBERON:0011094	biolink:AnatomicalEntity	vertebra cartilage element	The cartilaginous form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.	VHOG:0000584|EMAPA:32669	hp.json	vertebral cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0011094		
HP:0430019	biolink:PhenotypicFeature	Abnormality of muscle of facial expression	An abnormality of any of the muscles of facial expression, which are innervated by the seventh (VII) cranial nerve and control facial expression.	UMLS:C4073201	hp.json	Abnormality of musculature of facial expression|Abnormality of muscle of facial expression	http://purl.obolibrary.org/obo/HP_0430019		
UBERON:0035020	biolink:AnatomicalEntity	left vagus X nerve trunk		EMAPA:37798|MA:0001151|FMA:18157	hp.json	left vagus neural trunk|trunk of left vagus|anterior vagus X nerve trunk	http://purl.obolibrary.org/obo/UBERON_0035020		
UBERON:0011093	biolink:AnatomicalEntity	left pelvic girdle region	A pelvic girdle region that is in the left side of a multicellular organism.	FMA:16583	hp.json	left pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0011093		
HP:0033389	biolink:PhenotypicFeature	Bronchopulmonary anastomosis	Abnormal arterial anastomosis (connection) between bronchial and pulmonary arteries.		hp.json		http://purl.obolibrary.org/obo/HP_0033389		
HP:0033388	biolink:PhenotypicFeature	Abnormal bronchial artery morphology	Any structural abnormality of a bronchial artery.		hp.json		http://purl.obolibrary.org/obo/HP_0033388		
HP:0033385	biolink:PhenotypicFeature	Elevated urine pyridinoline level	An increased amount of pyridinoline in the urine.		hp.json	Elevated urine hydroxylysyl-pyridinoline level	http://purl.obolibrary.org/obo/HP_0033385		
HP:0033384	biolink:PhenotypicFeature	Elevated urinary collagen degradation products	Increased level in the urine of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease.		hp.json		http://purl.obolibrary.org/obo/HP_0033384		
HP:0033387	biolink:PhenotypicFeature	Elevated circulating pyridinoline concentration	An increased concentration of hydroxylysyl-pyridinoline (pyridinoline) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033387		
HP:0033386	biolink:PhenotypicFeature	Abnormal circulating collagen degradation product concentration	Abnormal concentration in the blood circulation of a metabolite that results from collagen degradation, e.g., a fragment of a collagen produced by a collagenase or serine protease.		hp.json		http://purl.obolibrary.org/obo/HP_0033386		
HP:0430010	biolink:PhenotypicFeature	Microblepharia	Abnormal shortness of the vertical dimensions of the eyelids.	UMLS:C0685873|SNOMEDCT_US:94684003	hp.json	Abnormally small eyelid	http://purl.obolibrary.org/obo/HP_0430010		
HP:0430018	biolink:PhenotypicFeature	Abnormality of nasal musculature	An abnormality of the muscles of the structure of the nose.	UMLS:C4073200	hp.json	Abnormality of nasal musculature|Abnormality of musculature of the nose|Abnormality of muscle of nose	http://purl.obolibrary.org/obo/HP_0430018		
HP:0430017	biolink:PhenotypicFeature	Abnormality of uvular muscle	An abnormality of the uvular muscle	UMLS:C4073199	hp.json	Abnormality of musculus uvulae	http://purl.obolibrary.org/obo/HP_0430017		
HP:0430016	biolink:PhenotypicFeature	Abnormality of tensor veli palatini muscle	An abnormality of the tensor veli palatini muscle	UMLS:C4073198	hp.json		http://purl.obolibrary.org/obo/HP_0430016		
HP:0430015	biolink:PhenotypicFeature	Abnormal morphology of musculature of pharynx	An abnormality of any of the muscles of the pharynx.	UMLS:C4073197	hp.json	Abnormality of muscles of the pharynx|Abnormality of pharyngeal musculature|Abnormality of musculature of pharynx|Abnormality of pharynx musculature	http://purl.obolibrary.org/obo/HP_0430015		
HP:0430014	biolink:PhenotypicFeature	Abnormality of musculature of soft palate	An abnormality of one or more of the five muscles of the soft palate.	UMLS:C4073196	hp.json	Abnormality of soft palate muscles	http://purl.obolibrary.org/obo/HP_0430014		
HP:0430013	biolink:PhenotypicFeature	Absent palatine bone ossification	Lack of formation of the palatine bone.	UMLS:C4021867	hp.json	Absence of palatine bone mineralization|Absence of palatine bone calcification|Absence of palatine bone formation	http://purl.obolibrary.org/obo/HP_0430013		
HP:0430012	biolink:PhenotypicFeature	Incomplete ossification of palatine bone	Failure to complete ossification (maturation and calcification) of the palatine bone.	UMLS:C0685213|SNOMEDCT_US:93595006	hp.json	Incomplete formation of palatine bone|Incomplete mineralization of palatine bone|Incomplete calcification of palatine bone	http://purl.obolibrary.org/obo/HP_0430012		
HP:0430011	biolink:PhenotypicFeature	Defect of palpebral conjunctiva	An abnormality of the palpebral conjunctiva.	UMLS:C4021868	hp.json		http://purl.obolibrary.org/obo/HP_0430011		
HP:0033392	biolink:PhenotypicFeature	Perivascular pre-capillary pulmonary artery inflammation	Inflammatory cell infiltration surrounding precapillary pulmonary arteries (arterioles; 20-70 micrometer).		hp.json	Perivascular inflammation of pre-capillary pulmonary arteries|Perivascular inflammation of arterioles in the pulmonary circulation	http://purl.obolibrary.org/obo/HP_0033392		
HP:0033391	biolink:PhenotypicFeature	Bronchial artery hypertrophy	Increase in the volume of bronchial artery wall due to the enlargement of its component cells.		hp.json		http://purl.obolibrary.org/obo/HP_0033391		
HP:0033394	biolink:PhenotypicFeature	Anti-carbonic anhydrase II antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against carbonic anhydrase II.		hp.json		http://purl.obolibrary.org/obo/HP_0033394		
HP:0033393	biolink:PhenotypicFeature	Irregularly shaped sperm tail	Irregular or changing caliber (diameter) along the tail of the sperm.		hp.json	Sperm flagella with irregular calibre|Sperm flagella with irregular caliber	http://purl.obolibrary.org/obo/HP_0033393		
GO:0046031	biolink:BiologicalProcess	ADP metabolic process	The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate.		hp.json	ADP metabolism	http://purl.obolibrary.org/obo/GO_0046031		
UBERON:0011085	biolink:AnatomicalEntity	palatoquadrate arch	The dorsal portion of the first pharyngeal arch, comprising the upper jaw[ZFIN,VHOG].	VHOG:0000511|TAO:0001272|EFO:0003659|ZFA:0001272	hp.json	palatoquadrate arch|upper pharyngeal jaw|dorsal pharyngeal arch 1|dorsal visceral arch 1|upper pharyngeal jaw|dorsal visceral arch 1|upper jaw|dorsal mandibular arch	http://purl.obolibrary.org/obo/UBERON_0011085		efo_slim
UBERON:0035032	biolink:AnatomicalEntity	abdominal oblique muscle	Either the external or internal abdominal oblique muscles.	MA:0003024|EMAPA:35603|MESH:D000071596	hp.json	oblique abdominal muscle	http://purl.obolibrary.org/obo/UBERON_0035032		
HP:0033390	biolink:PhenotypicFeature	Bronchial artery dilatation	Increased caliber of a bronchial artery, which can be defined as a bronchial artery diameter that exceeds 2 mm.		hp.json	Dilatation of a bronchial artery|Bronchial artery enlargement	http://purl.obolibrary.org/obo/HP_0033390		
UBERON:0035034	biolink:AnatomicalEntity	eyelid epithelium	An epithelium that is part of an eyelid [Automatically generated definition].	MA:0003163|EMAPA:32758	hp.json		http://purl.obolibrary.org/obo/UBERON_0035034		
UBERON:0011088	biolink:AnatomicalEntity	ligament of knee joint	A ligament that is part of a knee joint.	FMA:44580	hp.json	knee joint ligament	http://purl.obolibrary.org/obo/UBERON_0011088		human_reference_atlas
HP:0033399	biolink:PhenotypicFeature	Persistent fever	Fever that persists longer than expected for an acute infectious disease. No precise threshold exists, and the clinical interpretation of fever is context-dependent, but as a rule of thumb, this term refers to fever that persists longer than 2-3 weeks.		hp.json		http://purl.obolibrary.org/obo/HP_0033399		
UBERON:0035036	biolink:AnatomicalEntity	naris epithelium	An epithelium that is part of a naris [Automatically generated definition].	EMAPA:35959|MA:0003172	hp.json		http://purl.obolibrary.org/obo/UBERON_0035036		
GO:0048699	biolink:BiologicalProcess	generation of neurons	The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.		hp.json	neuron generation	http://purl.obolibrary.org/obo/GO_0048699		
HP:0033396	biolink:PhenotypicFeature	Glomerular extracapillary fibrin	Presence of ropey, eosinophilic material (brght red on Trichrome staining) consistent with extracapillary fibrin outside of capillary lumina.		hp.json		http://purl.obolibrary.org/obo/HP_0033396		
UBERON:0035038	biolink:AnatomicalEntity	carpal tunnel	The fibro-osseous passageway on the palmar side of the wrist that connects the distal forearm to the middle compartment of the deep plane of the palm.	FMA:42352	hp.json	carpal canal|carpel tunnel	http://purl.obolibrary.org/obo/UBERON_0035038		
HP:0033395	biolink:PhenotypicFeature	Antilactoferrin antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against lactoferrin.		hp.json		http://purl.obolibrary.org/obo/HP_0033395		
UBERON:0035037	biolink:AnatomicalEntity	jaw epithelium		MA:0003220|EMAPA:32904	hp.json		http://purl.obolibrary.org/obo/UBERON_0035037		
HP:0033398	biolink:PhenotypicFeature	Pleural plaque	Deposits of hyalinized collagen fibres in the parietal pleura (preferentially pleura adjacent to ribs, particularly the sixth through ninth ribs).		hp.json		http://purl.obolibrary.org/obo/HP_0033398		
GO:0046034	biolink:BiologicalProcess	ATP metabolic process	The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.		hp.json	ATP metabolism	http://purl.obolibrary.org/obo/GO_0046034		
UBERON:0035039	biolink:AnatomicalEntity	rectal artery		SCTID:277967008	hp.json	hemorrhoidal artery	http://purl.obolibrary.org/obo/UBERON_0035039		
HP:0033397	biolink:PhenotypicFeature	Bowman-space proteinaceous debris	The presence of eosinophilic Periodic Acid Schiff (PAS)-positive cell free, protein-derived material occupying Bowman's space.		hp.json		http://purl.obolibrary.org/obo/HP_0033397		
CL:1001599	biolink:Cell	pancreas exocrine glandular cell	Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts.	CALOHA:TS-1242|BTO:0000028	hp.json	exocrine pancreas glandular cell|pancreas exocrine glandular cells	http://purl.obolibrary.org/obo/CL_1001599		
HP:0430021	biolink:PhenotypicFeature	Abnormal common carotid artery morphology	An abnormality of the common carotid arteries, which provide the arterial supply to the head and neck and give rise to the internal carotid artery and the external carotid artery.	UMLS:C4073203	hp.json	Abnormality of the common carotid artery	http://purl.obolibrary.org/obo/HP_0430021		
HP:0430020	biolink:PhenotypicFeature	Abnormality of levator labii superioris alaeque nasi muscle	An abnormality of the levator labii superioris alaeque nasi muscle.	UMLS:C4073202	hp.json		http://purl.obolibrary.org/obo/HP_0430020		
CL:1001595	biolink:Cell	rectum glandular cell	Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells.	CALOHA:TS-1281	hp.json	rectal glandular cell|rectum glandular cells	http://purl.obolibrary.org/obo/CL_1001595		
CL:1001593	biolink:Cell	parathyroid glandular cell	Glandular cell of parathyroid epithelium. Example: Parathyroid chief cell and parathyroid oxyphil cells.	CALOHA:TS-1279	hp.json	parathyroid gland glandular cells|parathyroid gland glandular cell	http://purl.obolibrary.org/obo/CL_1001593		
CL:1001591	biolink:Cell	oviduct glandular cell	Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells.	CALOHA:TS-1277	hp.json	fallopian tube glandular cell|uterine tube glandular cell|fallopian tube glandular cells	http://purl.obolibrary.org/obo/CL_1001591		
HP:0430029	biolink:PhenotypicFeature	Hyperplasia of the premaxilla	An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively large in size compared to the other parts of the maxilla or other facial structures.	UMLS:C4073210	hp.json	Hyperplasia of the primary palate bone|Primary palate bone excess|Premaxillary excess|Hyperplasia of the intermaxillary bone|Increased size of premaxilla|Large premaxilla|Large primary palate bone|Increased size of the primary palate bone	http://purl.obolibrary.org/obo/HP_0430029		
HP:0430028	biolink:PhenotypicFeature	Hyperplasia of the maxilla	Abnormally increased dimension of the maxilla, especially relative to the mandible, resulting in a malocclusion or malalignment between the upper and lower teeth or in anterior positioning of the nasal base, increased convexity of the face, increased nasolabial angle, or increased width (transverse dimension of the maxilla.	UMLS:C4073209|SNOMEDCT_US:28070007|UMLS:C2227090|UMLS:C4280273|UMLS:C4280272|UMLS:C0266081	hp.json	Prominent upper jaw|Maxillary hyperplasia|Increased size of maxilla|Prognathia of the upper jaw|Hypertrophy of maxilla|Upper jaw bone excess|Maxillary prognathia|Maxillary excess|Prominent maxilla|Upper jaw excess|Increased projection of upper jaw|Big upper jaw|Maxillary prominence|Increased projection of maxilla|Large upper jaw|Big maxilla|Hypertrophy of upper jaw|Increased size of upper jaw|Hyperplasia of upper jaw|Large maxilla|Maxillary macrognathia	http://purl.obolibrary.org/obo/HP_0430028		
HP:0430026	biolink:PhenotypicFeature	obsolete Abnormality of the shape of the midface			hp.json		http://purl.obolibrary.org/obo/HP_0430026		
HP:0430025	biolink:PhenotypicFeature	Bilateral facial palsy	Two-sided or bilateral weakness of the muscles of facial expression and eye closure.	UMLS:C4073207	hp.json	Bilateral facial paralysis|Bilateral facial muscle weakness|Paralysis of both sides of the face|Weakness of both sides of the face|Bilateral facial muscle paralysis	http://purl.obolibrary.org/obo/HP_0430025		
HP:0430024	biolink:PhenotypicFeature	Abnormality of external jugular vein	An abnormality of an external jugular vein of the neck.	UMLS:C4073206	hp.json		http://purl.obolibrary.org/obo/HP_0430024		
HP:0430023	biolink:PhenotypicFeature	Abnormality of the maxillary sinus	An abnormality of the maxillary sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The maxillary sinus is located within the skeleton of the midface, lateral to the nasal cavity.	UMLS:C4073205	hp.json	Abnormality of the upper jaw sinus|Abnormality of the antrum of Highmore|Abnormality of the maxillary antrum	http://purl.obolibrary.org/obo/HP_0430023		
GO:0034067	biolink:BiologicalProcess	protein localization to Golgi apparatus	A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus.		hp.json	establishment of protein localization in Golgi|protein localization in Golgi apparatus|protein-Golgi targeting|protein targeting to Golgi|establishment of protein localisation to Golgi|establishment of protein localization to Golgi apparatus|establishment of protein localization to Golgi|protein localisation in Golgi apparatus	http://purl.obolibrary.org/obo/GO_0034067		
HP:0430022	biolink:PhenotypicFeature	Abnormality of the sphenoid sinus	An abnormality of the sphenoid sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The sphenoid sinus is located within the sphenoid bone.	UMLS:C4073204	hp.json	Abnormality of the sphenoidal sinus	http://purl.obolibrary.org/obo/HP_0430022		
NCBITaxon:2058949	biolink:OrganismalEntity	Dictyosteliales		GC_ID:1|PMID:29367151	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_2058949		
GO:0090327	biolink:NamedThing	negative regulation of locomotion involved in locomotory behavior			hp.json		http://purl.obolibrary.org/obo/GO_0090327		
GO:1905126	biolink:BiologicalProcess	regulation of axo-dendritic protein transport	Any process that modulates the frequency, rate or extent of axo-dendritic protein transport.		hp.json	regulation of axonal protein transport	http://purl.obolibrary.org/obo/GO_1905126		
PR:P37237	biolink:Protein	fibroblast growth factor 8 (mouse)	A fibroblast growth factor 8 that is encoded in the genome of mouse.	UniProtKB:P37237	hp.json	androgen-induced growth factor (mouse)|mFGF8|Fgf8|FGF-8 (mouse)|HBGF-8 (mouse)|heparin-binding growth factor 8 (mouse)|AIGF (mouse)|Aigf	http://purl.obolibrary.org/obo/PR_P37237		
GO:0090325	biolink:BiologicalProcess	regulation of locomotion involved in locomotory behavior	Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.		hp.json		http://purl.obolibrary.org/obo/GO_0090325		
GO:1905127	biolink:BiologicalProcess	negative regulation of axo-dendritic protein transport	Any process that stops, prevents or reduces the frequency, rate or extent of axo-dendritic protein transport.		hp.json	down-regulation of axo-dendritic protein transport|downregulation of axonal protein transport|down regulation of axo-dendritic protein transport|down regulation of axonal protein transport|inhibition of axo-dendritic protein transport|downregulation of axo-dendritic protein transport|down-regulation of axonal protein transport|negative regulation of axonal protein transport|inhibition of axonal protein transport	http://purl.obolibrary.org/obo/GO_1905127		
GO:1905128	biolink:BiologicalProcess	positive regulation of axo-dendritic protein transport	Any process that activates or increases the frequency, rate or extent of axo-dendritic protein transport.		hp.json	up regulation of axonal protein transport|upregulation of axo-dendritic protein transport|up-regulation of axonal protein transport|up-regulation of axo-dendritic protein transport|activation of axonal protein transport|upregulation of axonal protein transport|up regulation of axo-dendritic protein transport|activation of axo-dendritic protein transport|positive regulation of axonal protein transport	http://purl.obolibrary.org/obo/GO_1905128		
GO:0090326	biolink:NamedThing	positive regulation of locomotion involved in locomotory behavior			hp.json		http://purl.obolibrary.org/obo/GO_0090326		
GO:0090322	biolink:BiologicalProcess	regulation of superoxide metabolic process	Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.		hp.json	regulation of superoxide metabolism	http://purl.obolibrary.org/obo/GO_0090322		
GO:1905140	biolink:BiologicalProcess	regulation of apical ectodermal ridge formation	Any process that modulates the frequency, rate or extent of apical ectodermal ridge formation.		hp.json	regulation of crista ectodermalis apicalis formation|regulation of AER formation|regulation of apical epidermal ridge formation	http://purl.obolibrary.org/obo/GO_1905140		
GO:1905141	biolink:BiologicalProcess	negative regulation of apical ectodermal ridge formation	Any process that stops, prevents or reduces the frequency, rate or extent of apical ectodermal ridge formation.		hp.json	downregulation of apical ectodermal ridge formation|down-regulation of apical epidermal ridge formation|inhibition of apical ectodermal ridge formation|negative regulation of apical epidermal ridge formation|inhibition of crista ectodermalis apicalis formation|inhibition of AER formation|down-regulation of AER formation|negative regulation of AER formation|downregulation of crista ectodermalis apicalis formation|downregulation of apical epidermal ridge formation|down-regulation of apical ectodermal ridge formation|down regulation of AER formation|down regulation of apical ectodermal ridge formation|down regulation of crista ectodermalis apicalis formation|down regulation of apical epidermal ridge formation|downregulation of AER formation|negative regulation of crista ectodermalis apicalis formation|down-regulation of crista ectodermalis apicalis formation|inhibition of apical epidermal ridge formation	http://purl.obolibrary.org/obo/GO_1905141		
GO:1905142	biolink:BiologicalProcess	positive regulation of apical ectodermal ridge formation	Any process that activates or increases the frequency, rate or extent of apical ectodermal ridge formation.		hp.json	upregulation of apical epidermal ridge formation|up regulation of AER formation|up-regulation of apical ectodermal ridge formation|positive regulation of AER formation|positive regulation of crista ectodermalis apicalis formation|up regulation of apical ectodermal ridge formation|up regulation of crista ectodermalis apicalis formation|positive regulation of apical epidermal ridge formation|upregulation of AER formation|up regulation of apical epidermal ridge formation|activation of AER formation|up-regulation of crista ectodermalis apicalis formation|upregulation of apical ectodermal ridge formation|up-regulation of apical epidermal ridge formation|up-regulation of AER formation|upregulation of crista ectodermalis apicalis formation	http://purl.obolibrary.org/obo/GO_1905142		
GO:1905139	biolink:BiologicalProcess	apical ectodermal ridge formation	The process that gives rise to the apical ectodermal ridge. This process pertains to the initial formation of a structure from unspecified parts.		hp.json	crista ectodermalis apicalis formation|apical epidermal ridge formation|AER formation	http://purl.obolibrary.org/obo/GO_1905139		
PR:P01270	biolink:Protein	parathyroid hormone (human)	A parathyroid hormone that is encoded in the genome of human.	UniProtKB:P01270	hp.json	parathormone (human)|hPTH|PTH|parathyrin (human)	http://purl.obolibrary.org/obo/PR_P01270		
GO:0090330	biolink:BiologicalProcess	regulation of platelet aggregation	Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.		hp.json		http://purl.obolibrary.org/obo/GO_0090330		
GO:0090331	biolink:BiologicalProcess	negative regulation of platelet aggregation	Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.		hp.json	platelet disaggregation	http://purl.obolibrary.org/obo/GO_0090331		
PR:P01275	biolink:Protein	pro-glucagon (human)	A pro-glucagon that is encoded in the genome of human.	Reactome:R-HSA-400456|UniProtKB:P01275	hp.json	GCG|hGCG	http://purl.obolibrary.org/obo/PR_P01275		
GO:1905147	biolink:BiologicalProcess	regulation of smooth muscle hypertrophy	Any process that modulates the frequency, rate or extent of smooth muscle hypertrophy.		hp.json		http://purl.obolibrary.org/obo/GO_1905147		
GO:1905148	biolink:BiologicalProcess	negative regulation of smooth muscle hypertrophy	Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle hypertrophy.		hp.json	down-regulation of smooth muscle hypertrophy|down regulation of smooth muscle hypertrophy|downregulation of smooth muscle hypertrophy|inhibition of smooth muscle hypertrophy	http://purl.obolibrary.org/obo/GO_1905148		
GO:1905149	biolink:BiologicalProcess	positive regulation of smooth muscle hypertrophy	Any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy.		hp.json	up regulation of smooth muscle hypertrophy|activation of smooth muscle hypertrophy|upregulation of smooth muscle hypertrophy|up-regulation of smooth muscle hypertrophy	http://purl.obolibrary.org/obo/GO_1905149		
GO:0090303	biolink:BiologicalProcess	positive regulation of wound healing	Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.		hp.json		http://purl.obolibrary.org/obo/GO_0090303		
GO:0090304	biolink:BiologicalProcess	nucleic acid metabolic process	Any cellular metabolic process involving nucleic acids.		hp.json		http://purl.obolibrary.org/obo/GO_0090304		
GO:0090301	biolink:BiologicalProcess	negative regulation of neural crest formation	Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.		hp.json		http://purl.obolibrary.org/obo/GO_0090301		
GO:0090300	biolink:BiologicalProcess	positive regulation of neural crest formation	Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.		hp.json		http://purl.obolibrary.org/obo/GO_0090300		
GO:0090316	biolink:BiologicalProcess	positive regulation of intracellular protein transport	Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.		hp.json		http://purl.obolibrary.org/obo/GO_0090316		
GO:0090317	biolink:BiologicalProcess	negative regulation of intracellular protein transport	Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.		hp.json		http://purl.obolibrary.org/obo/GO_0090317		
HP:0001528	biolink:PhenotypicFeature	Hemihypertrophy	Overgrowth of only one side of the body.	UMLS:C0332890|SNOMEDCT_US:56007004|SNOMEDCT_US:205838004	hp.json	Asymmetric limb hypertrophy|Asymmetric overgrowth	http://purl.obolibrary.org/obo/HP_0001528		
HP:0001525	biolink:PhenotypicFeature	Severe failure to thrive		UMLS:C1855514	hp.json	Marked failure to thrive|Severe weight faltering|Severe faltering weight|Severe postnatal failure to thrive	http://purl.obolibrary.org/obo/HP_0001525		
HP:0001520	biolink:PhenotypicFeature	Large for gestational age	The term large for gestational age applies to babies whose birth weight lies above the 90th percentile for that gestational age.	UMLS:C1848395	hp.json	Macrosomia, neonatal|Birth weight > 90th percentile|Fetal macrosomia|Birthweight > 90th percentile|Macrosomia|Foetal macrosomia	http://purl.obolibrary.org/obo/HP_0001520		
HP:0001522	biolink:PhenotypicFeature	Death in infancy	Death within the first 24 months of life.	UMLS:C1858430|UMLS:C1844947	hp.json	Infantile death|Death in early childhood|Death in infancy|Lethal in infancy	http://purl.obolibrary.org/obo/HP_0001522		
GO:0090368	biolink:BiologicalProcess	regulation of ornithine metabolic process	Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.		hp.json		http://purl.obolibrary.org/obo/GO_0090368		
HP:0001538	biolink:PhenotypicFeature	Protuberant abdomen	A thrusting or bulging out of the abdomen.	UMLS:C1854928	hp.json	Belly sticks out|Abdominal protuberance|Extended belly	http://purl.obolibrary.org/obo/HP_0001538		
HP:0001539	biolink:PhenotypicFeature	Omphalocele	A midline anterior incomplete closure of the abdominal wall in which there is herniation of the abdominal viscera into the base of the abdominal cord.	UMLS:C0795690|MSH:D006554|MEDDRA:10030309|SNOMEDCT_US:18735004|Fyler:4404	hp.json	Omphalocoele|Exomphalos	http://purl.obolibrary.org/obo/HP_0001539		hposlim_core
HP:0001537	biolink:PhenotypicFeature	Umbilical hernia	Protrusion of abdominal contents through a defect in the abdominal wall musculature around the umbilicus. Skin and subcutaneous tissue overlie the defect.	Fyler:4445|UMLS:C0019322|SNOMEDCT_US:396347007	hp.json	Umbilical hernias	http://purl.obolibrary.org/obo/HP_0001537		hposlim_core
HP:0001530	biolink:PhenotypicFeature	Mild postnatal growth retardation	A mild degree of slow or limited growth after birth, being between two and three standard deviations below age- and sex-related norms.	UMLS:C3550204|UMLS:C1835580	hp.json	Postnatal onset of mild growth retardation|Mild growth deficiency	http://purl.obolibrary.org/obo/HP_0001530		
HP:0001531	biolink:PhenotypicFeature	Failure to thrive in infancy		UMLS:C1867873	hp.json	Faltering weight in infancy|Weight faltering in infancy|Failure to thrive in first year of life	http://purl.obolibrary.org/obo/HP_0001531		
HP:0001533	biolink:PhenotypicFeature	Slender build	Asthenic habitus refers to a slender build with long limbs, an angular profile, and prominent muscles or bones.	UMLS:C1850573	hp.json	Slender build|Thin build|Asthenic habitus|Thin body habitus	http://purl.obolibrary.org/obo/HP_0001533		
HP:0001504	biolink:PhenotypicFeature	Metacarpal osteolysis		UMLS:C1854610	hp.json	Metacarpals osteolysis	http://purl.obolibrary.org/obo/HP_0001504		
HP:0001507	biolink:PhenotypicFeature	Growth abnormality		UMLS:C0262361	hp.json	Growth issue|Abnormal growth|Growth abnormality	http://purl.obolibrary.org/obo/HP_0001507		
HP:0001508	biolink:PhenotypicFeature	Failure to thrive	Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.	UMLS:C2315100|SNOMEDCT_US:36440009|SNOMEDCT_US:432788009|UMLS:C0231246	hp.json	Undergrowth|Poor weight gain|Postnatal failure to thrive|Weight faltering|Faltering weight	http://purl.obolibrary.org/obo/HP_0001508		
HP:0001501	biolink:PhenotypicFeature	6 metacarpals		UMLS:C1861360	hp.json	6 long bones of hand	http://purl.obolibrary.org/obo/HP_0001501		
HP:0001500	biolink:PhenotypicFeature	Broad finger	Increased width of a non-thumb digit of the hand.	UMLS:C1844906	hp.json	Wide fingers|Broad fingers|Broad finger	http://purl.obolibrary.org/obo/HP_0001500		hposlim_core
HP:0001518	biolink:PhenotypicFeature	Small for gestational age	Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age.	UMLS:C0235991|UMLS:C0024032|MSH:D007230|SNOMEDCT_US:276610007|SNOMEDCT_US:267258002	hp.json	Small for gestational age|Birth weight less than 10th percentile|Low birth weight	http://purl.obolibrary.org/obo/HP_0001518		
HP:0001519	biolink:PhenotypicFeature	Disproportionate tall stature	A tall and slim body build with increased arm span to height ratio (>1.05) and a reduced upper-to-lower segment ratio (<0.85), i.e., unusually long arms and legs. The extremities as well as the hands and feet are unusually slim.	SNOMEDCT_US:62250003|MSH:D054119|UMLS:C1836996|UMLS:C0003706	hp.json	Dolichostenomelia|Marfanoid habitus|Reduced upper-lower segment ratio|Marfanoid body habitus	http://purl.obolibrary.org/obo/HP_0001519		
GO:0090358	biolink:BiologicalProcess	positive regulation of tryptophan metabolic process	Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.		hp.json	positive regulation of tryptophan metabolism	http://purl.obolibrary.org/obo/GO_0090358		
HP:0001513	biolink:PhenotypicFeature	Obesity	Accumulation of substantial excess body fat.	SNOMEDCT_US:414915002|SNOMEDCT_US:414916001|MSH:D009765|UMLS:C0028754	hp.json	Obesity|Having too much body fat	http://purl.obolibrary.org/obo/HP_0001513		
HP:0001510	biolink:PhenotypicFeature	Growth delay	A deficiency or slowing down of growth pre- and postnatally.	UMLS:C0878787|SNOMEDCT_US:276617005|UMLS:C0151686|SNOMEDCT_US:444896005|UMLS:C1837385|UMLS:C0456070|UMLS:C3552463|SNOMEDCT_US:59576002	hp.json	Growth failure|Growth retardation|Growth delay|Retarded growth|Poor growth|Delayed growth|Very poor growth|Growth deficiency	http://purl.obolibrary.org/obo/HP_0001510		
HP:0001511	biolink:PhenotypicFeature	Intrauterine growth retardation	An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.	MSH:D005317|UMLS:C0015934|SNOMEDCT_US:22033007|UMLS:C1386048|MSH:D007236|SNOMEDCT_US:199612005|UMLS:C0021296	hp.json	Prenatal growth retardation|Small for gestational age infant|In utero growth retardation|Prenatal growth deficiency|Intrauterine growth retardation, IUGR|Prenatal onset growth retardation|Intrauterine growth restriction|IUGR|Prenatal-onset growth retardation|Intrauterine growth failure|Intrauterine retardation|Prenatal growth failure	http://purl.obolibrary.org/obo/HP_0001511		
GO:0090357	biolink:BiologicalProcess	regulation of tryptophan metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.		hp.json	regulation of tryptophan metabolism	http://purl.obolibrary.org/obo/GO_0090357		
UBERON:0018146	biolink:AnatomicalEntity	transverse process of lumbar vertebra	A transverse process that is part of a lumbar vertebra.	FMA:65469|FMA:16080	hp.json	costa lumbalis|lumbar transverse process	http://purl.obolibrary.org/obo/UBERON_0018146		
GO:2000508	biolink:BiologicalProcess	regulation of dendritic cell chemotaxis	Any process that modulates the frequency, rate or extent of dendritic cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_2000508		
GO:2000509	biolink:BiologicalProcess	negative regulation of dendritic cell chemotaxis	Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_2000509		
UBERON:0018144	biolink:AnatomicalEntity	cervical rib	A rib that is attached to a cervical vertebra.	EMAPA:37825|UBERONTEMP:d522e981-3a43-4cab-9862-4344b5c3ff22|MESH:D057070	hp.json		http://purl.obolibrary.org/obo/UBERON_0018144		
UBERON:0018145	biolink:AnatomicalEntity	lumbar rib	A rib that is attached to a lumbar vertebra.		hp.json		http://purl.obolibrary.org/obo/UBERON_0018145		
UBERON:0018142	biolink:AnatomicalEntity	caudal vertebra endochondral element	Any vertebra endochondral element that is part of the caudal region of the vertebral column (tail or coccyx).		hp.json	coccygeal vertebra element|tail vertebra element|coccyx vertebra element|caudal vertebra element	http://purl.obolibrary.org/obo/UBERON_0018142		
UBERON:0018143	biolink:AnatomicalEntity	transverse process of cervical vertebra	A transverse process that is part of a cervical vertebra.	FMA:23894|FMA:9913	hp.json		http://purl.obolibrary.org/obo/UBERON_0018143		
UBERON:0018149	biolink:AnatomicalEntity	angle of oral opening	The lateral limit of each lateral part of the oral fissure.	FMA:77269|MFMO:0000145	hp.json	angle of mouth|mouth angle	http://purl.obolibrary.org/obo/UBERON_0018149		
CL:0008007	biolink:Cell	visceral muscle cell	A muscle cell that is part of some visceral muscle		hp.json		http://purl.obolibrary.org/obo/CL_0008007		
CL:0008008	biolink:Cell	striated visceral muscle cell	A visceral muscle cell that is striated.  Examples include the visceral muscle cells of arhtropods.		hp.json		http://purl.obolibrary.org/obo/CL_0008008		
CHEBI:16336	biolink:ChemicalSubstance	hyaluronic acid	A mucopolysaccharide composed of N-acetylglucosamine and glucuronic acid subunits. It is found in the connective tissues of vertebrates. A principal constituent of the extracellular matrix (ECM), it mediates the growth and metastasis of tumour cells.	PMID:11122186|KEGG:C00518|Wikipedia:Hyaluronan|Beilstein:8538277|CAS:9004-61-9|KEGG:G10505|CAS:9004-61-9|KEGG:D08043|PMID:18056362|PMID:18290544|Reaxys:8187837|HMDB:HMDB0010366	hp.json	[beta-N-Acetyl-D-glucosaminyl(1,4)beta-D-glucuronosyl(1,3)]n|acido hialuronico|Hyaluronsaeure|acide hyaluronique|[beta-D-glucopyranuronosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->4)]n|Hyaluronic acid|hyaluronan	http://purl.obolibrary.org/obo/CHEBI_16336		3_STAR
CL:0008009	biolink:Cell	transversely striated visceral muscle cell	A visceral muscle that is transversely striated.  Examples include the visceral muscle cells of arthropods.		hp.json		http://purl.obolibrary.org/obo/CL_0008009		
CL:0008002	biolink:Cell	skeletal muscle fiber	A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.		hp.json		http://purl.obolibrary.org/obo/CL_0008002		
CL:0008000	biolink:Cell	non-striated muscle cell	Any muscle cell in which the fibers are not organised into sarcomeres.		hp.json		http://purl.obolibrary.org/obo/CL_0008000		
CL:0008001	biolink:Cell	hematopoietic precursor cell	Any hematopoietic cell that is a precursor of some other hematopoietic cell type.		hp.json		http://purl.obolibrary.org/obo/CL_0008001		
UBERON:0018135	biolink:AnatomicalEntity	fibrocollagenous connective tissue		FMA:83521	hp.json		http://purl.obolibrary.org/obo/UBERON_0018135		
UBERON:0018132	biolink:AnatomicalEntity	tail fat pad	Encapsulated adipose tissue that is part of a tail.		hp.json	tail fat depot	http://purl.obolibrary.org/obo/UBERON_0018132		
CL:0008017	biolink:Cell	adult skeletal muscle myoblast	A skeletal muscle myoblast that is part of a skeletal mucle.  These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers.		hp.json	myogenic precursor cell	http://purl.obolibrary.org/obo/CL_0008017		
CL:0008019	biolink:Cell	mesenchymal cell	A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration.		hp.json	mesenchyme cell	http://purl.obolibrary.org/obo/CL_0008019		
GO:2000510	biolink:BiologicalProcess	positive regulation of dendritic cell chemotaxis	Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_2000510		
PR:P27814	biolink:Protein	killer cell lectin-like receptor subfamily B member 1C (mouse)	A killer cell lectin-like receptor subfamily B member 1C that is encoded in the genome of mouse.	UniProtKB:P27814	hp.json	mKlrb1c|CD161 antigen-like family member C (mouse)|NKR-P1.9 (mouse)|Nkrp1c|NKR-P1 40 (mouse)|Ly-55c (mouse)|lymphocyte antigen 55c (mouse)|Ly55c|NKR-P1C (mouse)|Klrb1c|natural killer cell surface protein P1-40 (mouse)|CD161c (mouse)|NK1.1 (mouse)	http://purl.obolibrary.org/obo/PR_P27814		
CHEBI:5391	biolink:ChemicalSubstance	glucagon	A 29-amino acid peptide hormone consisting of His, Ser, Gln, Gly, Thr, Phe, Thr, Ser, Asp, Tyr, Ser, Lys, Tyr, Leu, Asp, Ser, Arg, Arg, Ala, Gln, Asp, Phe, Val, Gln, Trp, Leu, Met, Asn and Thr residues joined in sequence.	PMID:22166985|DrugBank:DB00040|PMID:22399501|PMID:22167521|PMID:22214853|Wikipedia:Glucagon|CAS:9007-92-5|PMID:22154917|CAS:9007-92-5|PMID:21940356|Reaxys:13191924|CAS:16941-32-5|PMID:22318544|PMID:22438981|PMID:22014161|PMID:22227186|PMID:22294753|PMID:22286080|KEGG:C01501|KEGG:D00116|PMID:22454291|Drug_Central:2994|PMID:22334714	hp.json	glucagonum|L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine|His-ser-glu(nh2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr|His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr|Glucagon|Glucagone|glucagon|HSQGTFTSDYSKYLDSRRAQDFVQWLMNT	http://purl.obolibrary.org/obo/CHEBI_5391		3_STAR
UBERON:0018120	biolink:AnatomicalEntity	right renal medulla interstitium	A renal medulla interstitium that is part of a right kidney.		hp.json	medullary interstitial tissue of right kidney	http://purl.obolibrary.org/obo/UBERON_0018120		
CHEBI:28300	biolink:ChemicalSubstance	glutamine	An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4.	CAS:585-21-7|KNApSAcK:C00001359|Beilstein:1723795|Reaxys:1723795|KEGG:C00303|CAS:6899-04-3|CAS:6899-04-3|Wikipedia:Glutamine|Gmelin:27318	hp.json	2,5-diamino-5-oxopentanoic acid|Glutamin|Hgln|glutamine|2-amino-4-carbamoylbutanoic acid|Glutamine|glutamic acid gamma-amide|2-Aminoglutaramic acid|Glutaminsaeure-5-amid	http://purl.obolibrary.org/obo/CHEBI_28300		3_STAR
GO:2000527	biolink:BiologicalProcess	regulation of myeloid dendritic cell chemotaxis	Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_2000527		
GO:2000528	biolink:BiologicalProcess	negative regulation of myeloid dendritic cell chemotaxis	Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_2000528		
GO:2000529	biolink:BiologicalProcess	positive regulation of myeloid dendritic cell chemotaxis	Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_2000529		
CHEBI:5386	biolink:ChemicalSubstance	globin		COMe:PRX000257|KEGG:C06258	hp.json	Globin|globins|pentacoordinate globin	http://purl.obolibrary.org/obo/CHEBI_5386		3_STAR
UBERON:0018113	biolink:AnatomicalEntity	left kidney interstitium	A kidney interstitium that is part of a left kidney.	FMA:74271	hp.json	stroma of left kidney|left renal stroma	http://purl.obolibrary.org/obo/UBERON_0018113		
UBERON:0018114	biolink:AnatomicalEntity	right kidney interstitium	A kidney interstitium that is part of a right kidney.	FMA:74270	hp.json	right renal stroma|stroma of right kidney	http://purl.obolibrary.org/obo/UBERON_0018114		
UBERON:0018111	biolink:AnatomicalEntity	muscle layer of rectum	A muscle layer that is part of the rectum.	FMA:15035	hp.json	tunica muscularis recti|tunica muscularis (rectum)|muscular coat of rectum|rectal muscularis propria|muscularis externa of rectum	http://purl.obolibrary.org/obo/UBERON_0018111		
UBERON:0018112	biolink:AnatomicalEntity	rectum smooth muscle tissue	Any portion of smooth muscle tissue that is part of the rectum.		hp.json	rectal smooth muscle tissue|rectum smooth muscle|smooth muscle of rectum	http://purl.obolibrary.org/obo/UBERON_0018112		
UBERON:0018119	biolink:AnatomicalEntity	left renal medulla interstitium	A renal medulla interstitium that is part of a left kidney.		hp.json	medullary interstitial tissue of left kidney	http://purl.obolibrary.org/obo/UBERON_0018119		
UBERON:0018117	biolink:AnatomicalEntity	left renal cortex interstitium	A renal cortex interstitium that is part of a left kidney.		hp.json	cortical interstitial tissue of left kidney	http://purl.obolibrary.org/obo/UBERON_0018117		
UBERON:0018118	biolink:AnatomicalEntity	right renal cortex interstitium	A renal cortex interstitium that is part of a right kidney.		hp.json	cortical interstitial tissue of right kidney	http://purl.obolibrary.org/obo/UBERON_0018118		
UBERON:0018115	biolink:AnatomicalEntity	left renal pelvis	A renal pelvis that is part of a left ureter.	FMA:15579	hp.json	pelvis of left ureter|renal pelvis of left kidney	http://purl.obolibrary.org/obo/UBERON_0018115		
UBERON:0018116	biolink:AnatomicalEntity	right renal pelvis	A renal pelvis that is part of a right ureter.	FMA:15578	hp.json	pelvis of right kidney|pelvis of right ureter	http://purl.obolibrary.org/obo/UBERON_0018116		
UBERON:0006135	biolink:AnatomicalEntity	myelinated nerve fiber	Axons of neurons encased in a lipoproteinaceous material called myelin. (MeSH).	NCIT:C12627|UMLS:C0027750|SCTID:362296008|FMA:5915|MESH:D009413|GAID:745	hp.json		http://purl.obolibrary.org/obo/UBERON_0006135		pheno_slim
UBERON:0006134	biolink:AnatomicalEntity	nerve fiber	A threadlike extension of a nerve cell and consists of an axon and myelin sheath (if it is myelinated) in the nervous system. There are nerve fibers in the central nervous system and peripheral nervous system. A nerve fiber may be myelinated and/or unmyelinated. In the central nervous system (CNS), myelin by oligodendroglia cells is formed. Schwann cells form myelin in the peripheral nervous system (PNS). Schwann cells also make a thin covering in an axon without myelin (in the PNS). A peripheral nerve fiber contains an axon, myelin sheath, schwann cells and its endoneurium. There are no endoneurium and schwann cells in the central nervous system.	BAMS:nfi|Wikipedia:Nervous_system_fiber|SCTID:88545005|FMA:5914|MESH:A08.663.542|MESH:D009412	hp.json	neurofibra|neurofibrum|neurofibra|nerve fibre|nerve fibers|neurofibra	http://purl.obolibrary.org/obo/UBERON_0006134		human_reference_atlas
UBERON:0006133	biolink:AnatomicalEntity	funiculus of neuraxis	The cerebrospinal nerves consist of numerous nerve fibers collected together and enclosed in membranous sheaths. A small bundle of fibers, enclosed in a tubular sheath, is called a funiculus; if the nerve is of small size, it may consist only of a single funiculus; but if large, the funiculi are collected together into larger bundles or fasciculi, which are bound together in a common membranous investment. Examples include: Anterior funiculus of the spinal cord Lateral funiculus of the spinal cord Posterior funiculus of the spinal cord Funiculus solitarius of the medulla Funiculus separans.	FMA:76738	hp.json		http://purl.obolibrary.org/obo/UBERON_0006133		
UBERON:0006136	biolink:AnatomicalEntity	unmyelinated nerve fiber		NCIT:C33835|UMLS:C0501409|SCTID:46920005|FMA:5916|MESH:D036421|GAID:767	hp.json	non-myelinated nerve fiber	http://purl.obolibrary.org/obo/UBERON_0006136		
PR:P01236	biolink:Protein	prolactin (human)	A prolactin that is encoded in the genome of human.	UniProtKB:P01236	hp.json	PRL|hPRL	http://purl.obolibrary.org/obo/PR_P01236		
CHEBI:16313	biolink:ChemicalSubstance	D-proline	The D-enantiomer of proline.	DrugBank:DB02853|HMDB:HMDB0003411|CAS:344-25-2|Reaxys:80811|Beilstein:80811|MetaCyc:D-PROLINE|PMID:21563681|PMID:19023642|Wikipedia:D-proline|PMID:20023020|CAS:344-25-2|PMID:20959625|Gmelin:833984|KEGG:C00763|PMID:22479580|PDBeChem:DPR|PMID:22475019|PMID:21374575	hp.json	(2R)-pyrrolidine-2-carboxylic acid|D-Proline|(R)-pyrrolidine-2-carboxylic acid|D-PROLINE|D-Prolin|(R)-2-Carboxypyrrolidine|D-proline|DPR	http://purl.obolibrary.org/obo/CHEBI_16313		3_STAR
UBERON:0006183	biolink:AnatomicalEntity	mesonephric glomerular capillary			hp.json		http://purl.obolibrary.org/obo/UBERON_0006183		
UBERON:0018156	biolink:AnatomicalEntity	malleal ligament	A skeletal ligament that attaches to the malleus.		hp.json		http://purl.obolibrary.org/obo/UBERON_0018156		
UBERON:0018154	biolink:AnatomicalEntity	ligament of middle ear	A ligament that is part of a middle ear.		hp.json		http://purl.obolibrary.org/obo/UBERON_0018154		
UBERON:0018151	biolink:AnatomicalEntity	skin of upper lip	A zone of skin that is part of a upper lip.	FMA:24765	hp.json	upper lip skin	http://purl.obolibrary.org/obo/UBERON_0018151		
UBERON:0006170	biolink:AnatomicalEntity	mesonephric capsule	The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0006170		
GO:1905114	biolink:BiologicalProcess	cell surface receptor signaling pathway involved in cell-cell signaling	Any cell surface receptor signaling pathway that is involved in cell-cell signaling.		hp.json	cell surface receptor linked signal transduction involved in cell-cell signaling|cell surface receptor linked signalling pathway involved in cell-cell signalling|cell surface receptor linked signaling pathway involved in cell-cell signaling|cell surface receptor linked signaling pathway involved in cell-cell signalling|cell surface receptor signaling pathway involved in cell-cell signalling|cell surface receptor linked signal transduction involved in cell-cell signalling|cell surface receptor linked signalling pathway involved in cell-cell signaling	http://purl.obolibrary.org/obo/GO_1905114		
UBERON:0018150	biolink:AnatomicalEntity	skin of lower lip	A zone of skin that is part of a lower lip.	FMA:24767|SCTID:281630002	hp.json	lower lip skin	http://purl.obolibrary.org/obo/UBERON_0018150		
GO:0006942	biolink:BiologicalProcess	regulation of striated muscle contraction	Any process that modulates the frequency, rate or extent of striated muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_0006942		
GO:0006940	biolink:BiologicalProcess	regulation of smooth muscle contraction	Any process that modulates the frequency, rate or extent of smooth muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_0006940		
GO:0006941	biolink:BiologicalProcess	striated muscle contraction	A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.		hp.json	sarcomeric muscle contraction	http://purl.obolibrary.org/obo/GO_0006941		
HP:0025497	biolink:PhenotypicFeature	Coronary artery spasm	A brief and sudden narrowing of a coronary artery.		hp.json	Coronary artery vasospasm	http://purl.obolibrary.org/obo/HP_0025497		
HP:0025498	biolink:PhenotypicFeature	Aceruloplasminemia	Absence of ceruloplasmin in the blood.		hp.json	Aceruloplasminaemia	http://purl.obolibrary.org/obo/HP_0025498		
HP:0025499	biolink:PhenotypicFeature	Class I obesity	Obesity with a body mass index of 30 to 34.9 kg per square meter.		hp.json	Obesity grade 1	http://purl.obolibrary.org/obo/HP_0025499		
UBERON:0008867	biolink:AnatomicalEntity	trabecular network of bone	The network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force.	NCIT:C82999|UMLS:C2826619	hp.json	bone trabecula|bone trabeculae	http://purl.obolibrary.org/obo/UBERON_0008867		pheno_slim
UBERON:0006208	biolink:AnatomicalEntity	auditory hillocks	A collection of protruberances derived from pharyngeal arches 1 and 2 that develop into the folds of the pinna and gradually shift upwards and backwards to their final position on the head.	EHDAA2:0000155|EHDAA:4685|NCIT:C34110|EMAPA:17280|VHOG:0001364	hp.json	auditory tubercles|auditory hillock of Hiss|hillock of Hiss|auricular hillock	http://purl.obolibrary.org/obo/UBERON_0006208		emapa_ehdaa2
HP:0025490	biolink:PhenotypicFeature	Myocardial bridging	A congenital variant of a coronary artery in which a portion of an epicardial coronary artery (most frequently the middle segment of the left anterior descending artery) takes an intramuscular course.		hp.json	Intramyocardial coronary artery course	http://purl.obolibrary.org/obo/HP_0025490		
UBERON:0006207	biolink:AnatomicalEntity	aortico-pulmonary spiral septum	The spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta[MP]. The aorticopulmonary septum is developmentally formed from neural crest, specifically the cardiac neural crest, and actively separates the aorta and pulmonary arteries and fuses with the interventricular septum within the heart during development. The actual mechanism of septation of the outflow tract is poorly understood, but is recognized as a dynamic process with contributions from contractile, hemodynamic, and extracellular matrix interactions.	Wikipedia:Aorticopulmonary_septum|EHDAA2:0000136|CALOHA:TS-2409|EMAPA:16827|VHOG:0000502|EHDAA:2592	hp.json	spiral septum|septum aorticopulmonale|aortico-pulmonary septum|spiral septum|septum aorticopulmonale|aorticopulmonary septum|aortic septum|aortico-pulmonary septum|aorticopulmonary septum|aortic septum	http://purl.obolibrary.org/obo/UBERON_0006207		emapa_ehdaa2|pheno_slim
HP:0025491	biolink:PhenotypicFeature	Venous stenosis	Narrowing of a vein due to intimal hyperplasia and fibrosis.		hp.json		http://purl.obolibrary.org/obo/HP_0025491		
UBERON:0006206	biolink:AnatomicalEntity	iridocorneal angle	Acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye[MP].	FMA:58577	hp.json	anterior chamber angle	http://purl.obolibrary.org/obo/UBERON_0006206		pheno_slim
HP:0025492	biolink:PhenotypicFeature	Microcoria	A small pupil (typically diameter less than 2 mm) that dilates poorly or not at all in response to topically administered mydriatic drugs.		hp.json		http://purl.obolibrary.org/obo/HP_0025492		
HP:0025493	biolink:PhenotypicFeature	Palmoplantar erythema	Redness of the skin of the palm of the hand and the sole of the foot caused by hyperemia of the capillaries in the lower layers of the skin.		hp.json		http://purl.obolibrary.org/obo/HP_0025493		
HP:0025494	biolink:PhenotypicFeature	Coated aorta	Regular circumferential periaortic fibrosis involving the whole aorta and leading to a coated aorta appearance on computed tomography scans		hp.json		http://purl.obolibrary.org/obo/HP_0025494		
UBERON:0008861	biolink:AnatomicalEntity	pyloric gastric gland	The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP].	NCIT:C33431|FMA:14922|EMAPA:27211|UMLS:C0227239	hp.json	pyloric antrum gland|pyloric mucuous gland|glandula pylorica|pyloric gland	http://purl.obolibrary.org/obo/UBERON_0008861		pheno_slim
UBERON:0006204	biolink:AnatomicalEntity	inguinal ligament	A band running from the pubic tubercle to the anterior superior iliac spine. Its anatomy is very important for operating on hernia patients. It forms the base of the inguinal canal through which an indirect inguinal hernia may develop. The inguinal ligament runs from the anterior superior iliac spine of the ilium to the pubic tubercle of the pubic bone. It is formed by the external abdominal oblique aponeurosis and is continuous with the fascia lata of the thigh.	FMA:19855	hp.json	fallopian ligament|Vesalius' ligament|Poupart's ligament	http://purl.obolibrary.org/obo/UBERON_0006204		
HP:0025495	biolink:PhenotypicFeature	Descending aorta hypoplasia	Significant luminal narrowing of a long segment of the descending aorta.		hp.json		http://purl.obolibrary.org/obo/HP_0025495		
UBERON:0006203	biolink:AnatomicalEntity	conchal part of pinna		FMA:61006|UMLS:C0229316|NCIT:C32362	hp.json	concha of pinna|concha auriculae|concha|concha of auricle	http://purl.obolibrary.org/obo/UBERON_0006203		pheno_slim
HP:0025496	biolink:PhenotypicFeature	Abnormal coronary artery physiology	Any anomaly of the function of a coronary artery.		hp.json		http://purl.obolibrary.org/obo/HP_0025496		
GO:0006949	biolink:BiologicalProcess	syncytium formation	The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0006949		goslim_pir
GO:0006955	biolink:BiologicalProcess	immune response	Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.		hp.json		http://purl.obolibrary.org/obo/GO_0006955		goslim_drosophila
GO:0006956	biolink:BiologicalProcess	complement activation	Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.		hp.json	complement response|complement cascade|complement activity	http://purl.obolibrary.org/obo/GO_0006956		
GO:0006954	biolink:BiologicalProcess	inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.	Wikipedia:Inflammation	hp.json	inflammation	http://purl.obolibrary.org/obo/GO_0006954		goslim_generic
GO:0006952	biolink:BiologicalProcess	defense response	Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.		hp.json	defense/immunity protein activity|antimicrobial peptide activity|defence response|physiological defense response	http://purl.obolibrary.org/obo/GO_0006952		
GO:0006950	biolink:BiologicalProcess	response to stress	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).		hp.json	response to biotic stress|response to abiotic stress	http://purl.obolibrary.org/obo/GO_0006950		gocheck_do_not_manually_annotate|goslim_plant|goslim_drosophila|goslim_metagenomics|goslim_aspergillus|goslim_chembl|goslim_generic|goslim_candida
HP:0025486	biolink:PhenotypicFeature	Fused labia majora	The outer labia are sealed together.		hp.json		http://purl.obolibrary.org/obo/HP_0025486		
UBERON:0008854	biolink:AnatomicalEntity	root of molar tooth	The part of a molar tooth that is implanted in the gum; mandibular and maxillary molars usually have two and three roots, respectively.	FMA:85302|EMAPA:37948	hp.json	molar tooth root|molar root	http://purl.obolibrary.org/obo/UBERON_0008854		pheno_slim
HP:0025487	biolink:PhenotypicFeature	Abnormality of bladder morphology	Any structural anomaly of the bladder.		hp.json		http://purl.obolibrary.org/obo/HP_0025487		
HP:0025488	biolink:PhenotypicFeature	Detrusor sphincter dyssynergia	A urodynamic anomaly characterized by bladder outlet obstruction from detrusor muscle contraction with concomitant involuntary urethral sphincter activation.		hp.json		http://purl.obolibrary.org/obo/HP_0025488		
GO:0043903	biolink:BiologicalProcess	regulation of biological process involved in symbiotic interaction	Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association.		hp.json	regulation of symbiotic process|regulation of symbiosis, encompassing mutualism through parasitism|regulation of interspecies interactions between organisms	http://purl.obolibrary.org/obo/GO_0043903		
UBERON:0008856	biolink:AnatomicalEntity	stomach muscularis externa	The smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines.	SCTID:362132003|FMA:14909	hp.json	tunica muscularis (gaster)|gastric muscularis|muscularis externa of stomach|tunica muscularis gastris|muscle layer of stomach	http://purl.obolibrary.org/obo/UBERON_0008856		pheno_slim
HP:0025489	biolink:PhenotypicFeature	Bladder duplication	A congenital anomaly characterized by the presence of two bladders.		hp.json		http://purl.obolibrary.org/obo/HP_0025489		
UBERON:0008858	biolink:AnatomicalEntity	pyloric canal	The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter.	EMAPA:37944|FMA:14580	hp.json	canalis pyloricus|canalis pyloricus	http://purl.obolibrary.org/obo/UBERON_0008858		pheno_slim
GO:0043900	biolink:BiologicalProcess	regulation of multi-organism process	Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.		hp.json		http://purl.obolibrary.org/obo/GO_0043900		
HP:0025480	biolink:PhenotypicFeature	Lipomyelomeningocele	A type of spinal dysraphism presenting as a subcutaneous fatty mass, that is, a spinal defect associated with lipomatous tissue, and covered by skin. The most usual location for lipomyelomeningocele is at the gluteal cleft.		hp.json		http://purl.obolibrary.org/obo/HP_0025480		
HP:0025481	biolink:PhenotypicFeature	Cervical hemivertebrae	Absence of one half of the vertebral body in the cervical spine.		hp.json		http://purl.obolibrary.org/obo/HP_0025481		
HP:0025482	biolink:PhenotypicFeature	Positive perchlorate discharge test	An abnormal result of the perchlorate discharge test. In this test, first radioactive iodine is administered, sufficinet time is allowed to pass so that the radioactive iodine is captured by the thyroid,and then, perchlorate is administered orally. The perchlorate displaces non-organified iodide from the thyroid. The perchlorate discharge test is considered positive (abnormal) if there is an abnormally rapid loss of radioactive iodine from the thyroid.		hp.json		http://purl.obolibrary.org/obo/HP_0025482		
CHEBI:16285	biolink:ChemicalSubstance	phytanic acid	A branched-chain saturated fatty acid consisting of hexadecanoic acid carrying methyl substituents at positions 3, 7, 11 and 15.	KEGG:C01607|PMID:9819701|PMID:12187408|CAS:14721-66-5|Beilstein:1789963|CAS:14721-66-5|Reaxys:1789963|LIPID_MAPS_instance:LMFA01020251|PMID:17956237	hp.json	3,7,11,15-tetramethyl-hexadecanoic acid|3,7,11,15-Tetramethyl-hexadecansaeure|3,7,11,15-tetramethyl hexadecanoic acid|Phytanic acid|3,7,11,15-tetramethylhexadecanoic acid	http://purl.obolibrary.org/obo/CHEBI_16285		3_STAR
HP:0025483	biolink:PhenotypicFeature	Abnormal circulating thyroglobulin level	A deviation from the normal concentration of thyroglobulin, a protein produced in the thyroid gland that acts as a precursor to thyrroid hormones.		hp.json		http://purl.obolibrary.org/obo/HP_0025483		
HP:0025484	biolink:PhenotypicFeature	Increased circulating thyroglobulin level	An abnormal elevation of the concentration of thyroglobulin, a protein produced in the thyroid gland that acts as a precursor to thyrroid hormones.		hp.json		http://purl.obolibrary.org/obo/HP_0025484		
GO:0006959	biolink:BiologicalProcess	humoral immune response	An immune response mediated through a body fluid.	Wikipedia:Humoral_immunity	hp.json		http://purl.obolibrary.org/obo/GO_0006959		
HP:0025485	biolink:PhenotypicFeature	Vaginal adenosis	Vaginal adenosis is defined by the presence of metaplastic cervical or endometrial epithelium within the vaginal wall, thought to be derived from persistent Müllerian (synonymous with paramesonephric) epithelium islets in postembryonic life.		hp.json		http://purl.obolibrary.org/obo/HP_0025485		
GO:0006925	biolink:BiologicalProcess	inflammatory cell apoptotic process	Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage.		hp.json	programmed cell death of inflammatory cells by apoptosis|programmed cell death, inflammatory cells|inflammatory cell apoptosis|killing of inflammatory cells|apoptosis of inflammatory cells|inflammatory cell programmed cell death by apoptosis	http://purl.obolibrary.org/obo/GO_0006925		
GO:0006921	biolink:BiologicalProcess	cellular component disassembly involved in execution phase of apoptosis	The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis.		hp.json	cellular component disassembly involved in apoptosis|cellular component disassembly involved in apoptotic process|disassembly of cell structures	http://purl.obolibrary.org/obo/GO_0006921		
NCBITaxon:6656	biolink:OrganismalEntity	Arthropoda		GC_ID:1	hp.json	arthropods|arthropods	http://purl.obolibrary.org/obo/NCBITaxon_6656		
CHEBI:65256	biolink:ChemicalSubstance	antimicrobial food preservative	A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299).		hp.json	antimicrobial preservatives|antimicrobial preservative|antimicrobial food preservatives	http://purl.obolibrary.org/obo/CHEBI_65256		3_STAR
CHEBI:65255	biolink:ChemicalSubstance	food preservative	Substances which are added to food in order to prevent decomposition caused by  microbial growth or by undesirable chemical changes.		hp.json	food preservatives	http://purl.obolibrary.org/obo/CHEBI_65255		3_STAR
HP:0025475	biolink:PhenotypicFeature	Erythematous macule	A macule (flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin) with a red or reddish color often associated with inflammation or irritation.		hp.json		http://purl.obolibrary.org/obo/HP_0025475		
UBERON:0008842	biolink:AnatomicalEntity	suspensory ligament of testis	The cranial atrophic portion of the urogenital ridge attached to the cranial pole of the intraabdominal embryonic testis.		hp.json	scrotal ligament	http://purl.obolibrary.org/obo/UBERON_0008842		
UBERON:0008843	biolink:AnatomicalEntity	gubernaculum testis	The fetal ligament attached to the inferior end of the epididymis and testis and, at its other end, to the bottom of the scrotum; it is present during, and is thought to guide, the descent of the testis into the scrotum and then atrophies.	MA:0003248|BTO:0002813|EMAPA:19089|FMA:20421	hp.json	gubernaculum|Hunter's gubernaculum|male gubernaculum	http://purl.obolibrary.org/obo/UBERON_0008843		
HP:0025476	biolink:PhenotypicFeature	Testicular lipomatosis	Multiple foci of adipocytes within the testicular interstitium, usually presenting as multiple bilateral ill-defined hyperechoic intratesticular lesions of different sizes but generally with maximum diameter of 4 mm.		hp.json		http://purl.obolibrary.org/obo/HP_0025476		
UBERON:0008844	biolink:AnatomicalEntity	gubernaculum (female)	A gubernaculum that is part of a female reproductive system.		hp.json	gubernaculum ovarii|female gubernaculum	http://purl.obolibrary.org/obo/UBERON_0008844		
HP:0025477	biolink:PhenotypicFeature	Periarticular calcification	Calcified deposits in soft tissue structures outside a joint.		hp.json		http://purl.obolibrary.org/obo/HP_0025477		
UBERON:0008845	biolink:AnatomicalEntity	nonskeletal ligament	A ligament that does not connect two skeletal elements.	MA:0003004|FMA:25625	hp.json	non-skeletal ligament|fibrous ligament	http://purl.obolibrary.org/obo/UBERON_0008845		
HP:0025478	biolink:PhenotypicFeature	Atrial standstill	Atrial standstill or silent atrium is a rare condition presenting with the absence of electrical and mechanical activity in the atria. It presents with the absence of P waves, bradycardia, and wide QRS complex in the electrocardiogram.		hp.json	Silent atrium	http://purl.obolibrary.org/obo/HP_0025478		
HP:0025479	biolink:PhenotypicFeature	Self-neglect	Neglecting one's own needs and well-being.		hp.json		http://purl.obolibrary.org/obo/HP_0025479		
UBERON:0008846	biolink:AnatomicalEntity	skeletal ligament	Dense regular connective tissue connecting two or more adjacent skeletal elements[VSAO,modified].	CALOHA:TS-2146|VSAO:0000072|MA:0003005|AAO:0010444|AEO:0000090|EV:0100144|FMA:25624|EHDAA2:0003232|GAID:118	hp.json	articular larua|true ligament|ligament|articular ligament	http://purl.obolibrary.org/obo/UBERON_0008846		
NCBITaxon:89593	biolink:OrganismalEntity	Craniata <chordates>		GC_ID:1	hp.json	Craniata	http://purl.obolibrary.org/obo/NCBITaxon_89593		
HP:0025470	biolink:PhenotypicFeature	Telogen effluvium	A type of hair loss characterized by an abnormal increase in dormant, telogen stage hair follicles.		hp.json		http://purl.obolibrary.org/obo/HP_0025470		
GO:0006928	biolink:BiologicalProcess	movement of cell or subcellular component	The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.		hp.json	cellular component motion|cell movement|cellular component movement	http://purl.obolibrary.org/obo/GO_0006928		goslim_pir|gocheck_do_not_annotate
HP:0025471	biolink:PhenotypicFeature	Congenital panfollicular nevus	A hamartomatous proliferation containing malformed hair follicles in various stages of development. Panfolliculomas are well-circumscribed lesions demonstrating all stages of follicular differentiation.		hp.json		http://purl.obolibrary.org/obo/HP_0025471		
HP:0025472	biolink:PhenotypicFeature	Recurrent plantar mycosis	A history of repeated fungal infections located on the sole of the foot, usually manifested by scaling, maceration, and itching.		hp.json		http://purl.obolibrary.org/obo/HP_0025472		
HP:0025473	biolink:PhenotypicFeature	Hyperpigmented papule	A papule (circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point) that exhibits increased pigmentation (is darker) compared to the surrounding skin.		hp.json		http://purl.obolibrary.org/obo/HP_0025473		
HP:0025474	biolink:PhenotypicFeature	Erythematous plaque	A plaque (a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter) with a red or reddish color often associated with inflammation or irritation.		hp.json	Violaceous plaque	http://purl.obolibrary.org/obo/HP_0025474		
UBERON:0008841	biolink:AnatomicalEntity	suspensory ligament	A ligament that supports a body part, especially an organ.		hp.json		http://purl.obolibrary.org/obo/UBERON_0008841		
GO:0006935	biolink:BiologicalProcess	chemotaxis	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).	Wikipedia:Chemotaxis	hp.json	taxis in response to chemical stimulus	http://purl.obolibrary.org/obo/GO_0006935		
GO:0006936	biolink:BiologicalProcess	muscle contraction	A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.	Wikipedia:Muscle_contraction	hp.json		http://purl.obolibrary.org/obo/GO_0006936		goslim_pir
HP:0025464	biolink:PhenotypicFeature	Increased reactive oxygen species production	An accumulation of free radical groups in the body inadequately neutralized by antioxidants, which creates a potentially unstable and damaging cellular environment linked to tissue damage.		hp.json	Oxidative stress|Increased ROS production	http://purl.obolibrary.org/obo/HP_0025464		
HP:0025465	biolink:PhenotypicFeature	Abnormal circulating beta globulin level	A deviation from the normal concentration of beta globulin. The beta globulins are a group of globular (globe-shaped) proteins in blood.		hp.json		http://purl.obolibrary.org/obo/HP_0025465		
HP:0025466	biolink:PhenotypicFeature	Beta 2-microglobulinuria	Increased level of beta 2-microglobulins in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0025466		
UBERON:0008833	biolink:AnatomicalEntity	great auricular nerve	A nerve arising from the second and third cervical nerves from the cervical plexus and innervating the skin over the parotid gland, the skin of part of the ear, the adjacent portion of the scalp, cheek, and angle of the jaw.	FMA:6872	hp.json	great auricular|nervus auricularis magnus|greater auricular nerve	http://purl.obolibrary.org/obo/UBERON_0008833		human_reference_atlas
UBERON:0008835	biolink:AnatomicalEntity	hepatic diverticulum	An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts.	XAO:0000101|UMLS:C1512407|EHDAA2:0000740|EHDAA:1530|AAO:0011057|NCIT:C34187	hp.json	liver diverticulum|diverticulum hepaticum	http://purl.obolibrary.org/obo/UBERON_0008835		pheno_slim
HP:0025469	biolink:PhenotypicFeature	Anagen effluvium	An abnormal loss of anagen (growth phase) hairs.		hp.json		http://purl.obolibrary.org/obo/HP_0025469		
UBERON:0008836	biolink:AnatomicalEntity	liver bud		BTO:0001642	hp.json		http://purl.obolibrary.org/obo/UBERON_0008836		
UBERON:0008837	biolink:AnatomicalEntity	palmar/plantar part of autopod			hp.json		http://purl.obolibrary.org/obo/UBERON_0008837		
GO:0006939	biolink:BiologicalProcess	smooth muscle contraction	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.		hp.json	visceral muscle contraction	http://purl.obolibrary.org/obo/GO_0006939		
HP:0025460	biolink:PhenotypicFeature	High myoinositol in brain by MRS	An elevated level of myoinositol in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json	High myo-inositol in brain by MRS	http://purl.obolibrary.org/obo/HP_0025460		
HP:0025461	biolink:PhenotypicFeature	Abnormal cell morphology	Any anomaly of cell structure.		hp.json		http://purl.obolibrary.org/obo/HP_0025461		
GO:0006937	biolink:BiologicalProcess	regulation of muscle contraction	Any process that modulates the frequency, rate or extent of muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_0006937		
HP:0025462	biolink:PhenotypicFeature	obsolete Abnormal cellular physiology			hp.json		http://purl.obolibrary.org/obo/HP_0025462		
HP:0025463	biolink:PhenotypicFeature	Abnormality of redox activity	An abnormality of the processes that maintain the redox environment of a cell or compartment within a cell, that is, the balance between reduction and oxidation chemical reactions.		hp.json		http://purl.obolibrary.org/obo/HP_0025463		
GO:0006903	biolink:BiologicalProcess	vesicle targeting	The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.		hp.json		http://purl.obolibrary.org/obo/GO_0006903		
UBERON:0018229	biolink:AnatomicalEntity	renin-angiotensin system	A system consisting of renin, angiotensin-converting enzyme, and angiotensin II. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming angiotensin I. The converting enzyme contained in the lung acts on angiotensin I in the plasma converting it to angiotensin II, the most powerful directly pressor substance known. It causes contraction of the arteriolar smooth muscle and has other indirect actions mediated through the adrenal cortex.	MESH:D012084|FMA:74787	hp.json	renin angiotensin system|renin angiotensin aldosterone system|renin-angiotensin system|renin-angiotensin-aldosterone system	http://purl.obolibrary.org/obo/UBERON_0018229		pheno_slim
GO:2000547	biolink:BiologicalProcess	regulation of dendritic cell dendrite assembly	Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly.		hp.json	regulation of dendritic extension	http://purl.obolibrary.org/obo/GO_2000547		
UBERON:0018227	biolink:AnatomicalEntity	pulmonary lymphatic vessel	A lymphatic vessel that is part of a lung.	FMA:234006	hp.json	lymphatic vessel of lung	http://purl.obolibrary.org/obo/UBERON_0018227		human_reference_atlas
GO:2000548	biolink:BiologicalProcess	negative regulation of dendritic cell dendrite assembly	Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly.		hp.json	negative regulation of dendritic extension	http://purl.obolibrary.org/obo/GO_2000548		
GO:2000549	biolink:BiologicalProcess	positive regulation of dendritic cell dendrite assembly	Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly.		hp.json	positive regulation of dendritic extension	http://purl.obolibrary.org/obo/GO_2000549		
UBERON:0018226	biolink:AnatomicalEntity	pulmonary part of lymphatic system	An organ system subdivision that is the part of the lymphoid system that includes the pulmonary lymphatic vessels.	FMA:67999	hp.json	pulmonary lymphatic vasculature|pulmonary lymphatic chain	http://purl.obolibrary.org/obo/UBERON_0018226		pheno_slim
UBERON:0006245	biolink:AnatomicalEntity	humerus cartilage element	A humerus endochondral element that is composed primarily of cartilage tissue.	EMAPA:17713|EHDAA:6240|VHOG:0001120|EHDAA2:0000787	hp.json	humeral cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0006245		emapa_ehdaa2
UBERON:0006244	biolink:AnatomicalEntity	hip joint primordium		EHDAA:8462|EHDAA2:0000785|EMAPA:17739	hp.json		http://purl.obolibrary.org/obo/UBERON_0006244		emapa_ehdaa2
UBERON:0006242	biolink:AnatomicalEntity	gall bladder primordium	A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops.	XAO:0004205|EHDAA2:0000700|EHDAA:3047|EMAPA:16713	hp.json		http://purl.obolibrary.org/obo/UBERON_0006242		emapa_ehdaa2
UBERON:0006241	biolink:AnatomicalEntity	future spinal cord		EMAPA:16755|TAO:0000417|EHDAA:898|EFO:0003438|EHDAA2:0000674|ZFA:0000417|EMAPA:16092	hp.json	presumptive spinal cord neural keel|presumptive spinal cord|presumptive spinal cord neural rod|presumptive spinal cord neural plate	http://purl.obolibrary.org/obo/UBERON_0006241		vertebrate_core|efo_slim
GO:0043931	biolink:BiologicalProcess	ossification involved in bone maturation	The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.		hp.json	ossification involved in skeletal development|ossification involved in bone modeling	http://purl.obolibrary.org/obo/GO_0043931		
UBERON:0006240	biolink:AnatomicalEntity	future forebrain	A presumptive structure that has the potential to develop into a forebrain.	EMAPA:16640|EHDAA:2643|BAMS:Pros|EHDAA2:0000661|ZFA:0000062|EFO:0003423|Wikipedia:Prosencephalon|TAO:0000062	hp.json	presumptive forebrain|future prosencephalon|prosencephalon|presumptive prosencephalon	http://purl.obolibrary.org/obo/UBERON_0006240		vertebrate_core|emapa_ehdaa2|efo_slim
NCBITaxon:436489	biolink:OrganismalEntity	Saurischia		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_436489		
GO:0043933	biolink:BiologicalProcess	protein-containing complex organization	Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex.		hp.json	cellular macromolecular complex organization|protein-containing complex subunit organization|cellular macromolecular complex subunit organization|protein complex subunit organisation|macromolecular complex subunit organisation|protein complex subunit organization|macromolecular complex organization|cellular macromolecular complex subunit organisation|macromolecular complex subunit organization	http://purl.obolibrary.org/obo/GO_0043933		
NCBITaxon:436486	biolink:OrganismalEntity	Dinosauria		GC_ID:1	hp.json	dinosaurs|dinosaur	http://purl.obolibrary.org/obo/NCBITaxon_436486		
GO:2000542	biolink:BiologicalProcess	negative regulation of gastrulation	Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation.		hp.json		http://purl.obolibrary.org/obo/GO_2000542		
GO:0043932	biolink:BiologicalProcess	ossification involved in bone remodeling	The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.		hp.json	ossification involved in bone remodelling	http://purl.obolibrary.org/obo/GO_0043932		
GO:2000543	biolink:BiologicalProcess	positive regulation of gastrulation	Any process that activates or increases the frequency, rate or extent of gastrulation.		hp.json		http://purl.obolibrary.org/obo/GO_2000543		
GO:0006909	biolink:BiologicalProcess	phagocytosis	A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.	Wikipedia:Phagocytosis	hp.json		http://purl.obolibrary.org/obo/GO_0006909		
GO:0006906	biolink:BiologicalProcess	vesicle fusion	Fusion of the membrane of a transport vesicle with its target membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0006906		
UBERON:0006248	biolink:AnatomicalEntity	incus pre-cartilage condensation	An incus endochondral element that is composed primarily of a pre-cartilage condensation.	EMAPA:17825|EHDAA:9024|EHDAA2:0000813|VHOG:0000957	hp.json		http://purl.obolibrary.org/obo/UBERON_0006248		emapa_ehdaa2
UBERON:0006247	biolink:AnatomicalEntity	iliac pre-cartilage condensation	An iliac endochondral element that is composed primarily of a pre-cartilage condensation.	EMAPA:18029|EHDAA2:0000809|EHDAA:9568|VHOG:0000964	hp.json		http://purl.obolibrary.org/obo/UBERON_0006247		emapa_ehdaa2
UBERON:0006246	biolink:AnatomicalEntity	humerus pre-cartilage condensation	A humerus endochondral element that is composed primarily of a pre-cartilage condensation.	VHOG:0000950|EMAPA:17427|EHDAA:4192|EHDAA2:0000788	hp.json	humeral pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0006246		emapa_ehdaa2
UBERON:0006234	biolink:AnatomicalEntity	femur pre-cartilage condensation	A femur endochondral element that is composed primarily of a pre-cartilage condensation.	VHOG:0000951|EHDAA2:0000508|EMAPA:17502	hp.json	femoral pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0006234		emapa_ehdaa2
UBERON:0006233	biolink:AnatomicalEntity	female genital tubercle	A differentiated genital tubercle that is part of a female reproductive system.	VHOG:0000666|RETIRED_EHDAA2:0000500|EHDAA:8118|EMAPA:18680	hp.json	genital tubercle of female	http://purl.obolibrary.org/obo/UBERON_0006233		emapa_ehdaa2
UBERON:0006232	biolink:AnatomicalEntity	facio-acoustic VII-VIII preganglion complex		RETIRED_EHDAA2:0000496|EHDAA:1477|VHOG:0000715|EMAPA:16660	hp.json	facio-acoustic preganglion complex	http://purl.obolibrary.org/obo/UBERON_0006232		emapa_ehdaa2
CHEBI:28260	biolink:ChemicalSubstance	galactose	An aldohexose that is the C-4 epimer of glucose.	CAS:26566-61-0|Wikipedia:Galactose|CAS:26566-61-0|KEGG:C01582	hp.json	Gal|galactose|Galactose|Galaktose|galacto-hexose	http://purl.obolibrary.org/obo/CHEBI_28260		3_STAR
UBERON:0006230	biolink:AnatomicalEntity	extrinsic ocular pre-muscle mass		EMAPA:17845|EHDAA:2925|EHDAA2:0000483	hp.json		http://purl.obolibrary.org/obo/UBERON_0006230		emapa_ehdaa2
CHEBI:16247	biolink:ChemicalSubstance	phospholipid	A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides.	KEGG:C00865	hp.json	a phospholipid derivative|phospholipids|Phospholipid	http://purl.obolibrary.org/obo/CHEBI_16247		3_STAR
OBO:chebi#is_tautomer_of	biolink:NamedThing	is tautomer of			hp.json		http://purl.obolibrary.org/obo/chebi#is_tautomer_of		
UBERON:0006239	biolink:AnatomicalEntity	future central tendon	A tendon that has the potential to develop into a central tendon.	EHDAA2:0000593|EMAPA:25035|EHDAA:4118	hp.json	cranial derivative of septum transversum|cranial derivative of septum transversum|cranial part of septum transversum|cranial part of septum transversum	http://purl.obolibrary.org/obo/UBERON_0006239		emapa_ehdaa2
UBERON:0006238	biolink:AnatomicalEntity	future brain	The embryonic precursor of the brain.	FMA:312967|BAMS:Enc|EFO:0003431|ZFA:0000146|EHDAA:830|EMAPA:16089|TAO:0000146|BTO:0004726|EHDAA:300|RETIRED_EHDAA2:0000591	hp.json	brain rudiment|presumptive brain|embryonic brain|encephalon	http://purl.obolibrary.org/obo/UBERON_0006238		efo_slim|cumbo|vertebrate_core|emapa_ehdaa2
NCBITaxon:436491	biolink:OrganismalEntity	Theropoda		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_436491		
NCBITaxon:436492	biolink:OrganismalEntity	Coelurosauria		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_436492		
UBERON:0008895	biolink:AnatomicalEntity	splanchnocranium	Subdivision of endoskeleton derived from pharyngeal arches.	ZFA:0001216|TAO:0001216|Wikipedia:Facial_skeleton|AAO:0010157|XAO:0003176|VSAO:0000149|VHOG:0000315	hp.json	gill arch skeleton|branchial arch skeleton|viscerocranium|pharyngeal arch|pharyngeal skeleton|visceral skeletal system|visceral cranium|visceral skeletal system|visceral cranium|pharyngeal endoskeleton|pharyngeal endoskeleton|viscerocranium|pharyngeal arch skeleton|visceral skeleton	http://purl.obolibrary.org/obo/UBERON_0008895		
GO:0006915	biolink:BiologicalProcess	apoptotic process	A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.	Wikipedia:Apoptosis	hp.json	apoptosis|type I programmed cell death|signaling (initiator) caspase activity|cell suicide|apoptosis activator activity|caspase-dependent programmed cell death|commitment to apoptosis|induction of apoptosis|apoptosis signaling|apoptotic programmed cell death|apoptotic cell death|cellular suicide|apoptotic program|programmed cell death by apoptosis|induction of apoptosis by p53|activation of apoptosis	http://purl.obolibrary.org/obo/GO_0006915		
UBERON:0006236	biolink:AnatomicalEntity	tetrapod frontal bone primordium		FMA:312589|EHDAA:9540|EMAPA:18017|EHDAA2:0000577	hp.json	frontal bone primordium	http://purl.obolibrary.org/obo/UBERON_0006236		emapa_ehdaa2
UBERON:0006235	biolink:AnatomicalEntity	foregut-midgut junction	An anatomical junctions that overlaps the foregut and midgut.	EHDAA:526|EHDAA2:0000569|EMAPA:16363|VHOG:0000291	hp.json		http://purl.obolibrary.org/obo/UBERON_0006235		emapa_ehdaa2
UBERON:0008896	biolink:AnatomicalEntity	post-hyoid pharyngeal arch	A pharyngeal arch that is posterior to the hyoid arch. i.e. any pharyngeal arch with a number 3 or higher.	AAO:0010362|ZFA:0001613|EFO:0003694|BTO:0002152|SCTID:308766004|XAO:0000099|TAO:0001597	hp.json	visceral arches 3-7|branchial bar|branchial arches|branchial arch|gill arch|gill bar|branchial bars|pharyngeal arch 3-7|gill arches 1-5|gill bar	http://purl.obolibrary.org/obo/UBERON_0008896		efo_slim
CL:0008030	biolink:Cell	excitatory neuron			hp.json		http://purl.obolibrary.org/obo/CL_0008030		
UBERON:8420000	biolink:AnatomicalEntity	hair of scalp	Hair that grows on the scalp.		hp.json	hair	http://purl.obolibrary.org/obo/UBERON_8420000		
CHEBI:65296	biolink:ChemicalSubstance	primary ammonium ion	An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3.		hp.json	substituted ammonium|a primary amine	http://purl.obolibrary.org/obo/CHEBI_65296		3_STAR
UBERON:0008886	biolink:AnatomicalEntity	pulmonary vascular system	The part of the cardiovascular system consisting of all pulmonary arteries and all pulmonary veins.	FMA:45621|Wikipedia:Pulmonary_circulation	hp.json	pulmonary system|pulmonary circulatory system	http://purl.obolibrary.org/obo/UBERON_0008886		
UBERON:0008887	biolink:AnatomicalEntity	rectal venous plexus	The hemorrhoidal plexus (or rectal venous plexus) surrounds the rectum, and communicates in front with the vesical venous plexus in the male, and the uterovaginal plexus in the female. A free communication between the portal and systemic venous systems is established through the hemorrhoidal plexus.	NCIT:C32728|FMA:18933|UMLS:C0226766	hp.json	haemorrhoidal plexus|hemorrhoidal plexus|plexus haemorrhoidalis|plexus venosus rectalis	http://purl.obolibrary.org/obo/UBERON_0008887		
UBERON:0006222	biolink:AnatomicalEntity	future diencephalon	The foremost region of the future forebrain that develops into the diencephalon.	EFO:0003442|EMAPA:16514|EHDAA:844|RETIRED_EHDAA2:0000386|EHDAA2:0000600|ZFA:0000574|TAO:0000574	hp.json	presumptive diencephalon	http://purl.obolibrary.org/obo/UBERON_0006222		efo_slim|vertebrate_core|emapa_ehdaa2
CL:0008028	biolink:Cell	visual system neuron			hp.json		http://purl.obolibrary.org/obo/CL_0008028		
CL:0008024	biolink:Cell	pancreatic endocrine cell	An endocrine cell that is part of the pancreas.		hp.json		http://purl.obolibrary.org/obo/CL_0008024		
UBERON:0006227	biolink:AnatomicalEntity	ethmoid bone primordium		EHDAA:8363|FMA:312597|EHDAA2:0000456|EMAPA:18023	hp.json		http://purl.obolibrary.org/obo/UBERON_0006227		emapa_ehdaa2
UBERON:0008882	biolink:AnatomicalEntity	spinal cord commissure	The nerve fiber tracts that span the midline of the spinal cord.	EMAPA:37955	hp.json		http://purl.obolibrary.org/obo/UBERON_0008882		pheno_slim
UBERON:0008883	biolink:AnatomicalEntity	osteoid	Bone tissue that is an unmineralized bone matrix deposited by osteoblasts prior to the mineralization of bone tissue.	galen:Osteoid|FMA:66830|VSAO:0000046|NCIT:C33228|EMAPA:37923|XAO:0004035|UMLS:C0682561	hp.json	pre-bone|osteoid tissue|prebone tissue|prebone	http://purl.obolibrary.org/obo/UBERON_0008883		pheno_slim
UBERON:0008884	biolink:AnatomicalEntity	left putamen	A putamen that is part of a left cerebral hemisphere.	FMA:72829|HBA:4288	hp.json		http://purl.obolibrary.org/obo/UBERON_0008884		
CL:0008022	biolink:Cell	endocardial cushion cell	A mesenchymal cell of the endocardial cushion.   These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves.		hp.json		http://purl.obolibrary.org/obo/CL_0008022		
UBERON:0008885	biolink:AnatomicalEntity	right putamen	A putamen that is part of a right cerebral hemisphere.	FMA:72828|HBA:4289	hp.json		http://purl.obolibrary.org/obo/UBERON_0008885		
UBERON:0006224	biolink:AnatomicalEntity	elbow joint primordium		EHDAA:8483|EMAPA:17710|EHDAA2:0000431	hp.json		http://purl.obolibrary.org/obo/UBERON_0006224		emapa_ehdaa2
UBERON:0006211	biolink:AnatomicalEntity	buccopharyngeal membrane	The thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx.	EHDAA2:0000189|FMA:313607|SCTID:361412007|Wikipedia:Buccopharyngeal_membrane|EMAPA:16259|EHDAA:536|VHOG:0000380	hp.json	oral membrane|oral plate|pharyngeal membrane|oropharyngeal membrane|oropharyngeal membrane	http://purl.obolibrary.org/obo/UBERON_0006211		pheno_slim|emapa_ehdaa2
UBERON:0008876	biolink:AnatomicalEntity	hypodermis skeletal muscle layer	Any skeletal muscle organ in the hypodermis / superficial fascia.	MA:0003140|EMAPA:18188	hp.json	panniculus carnosus|hypodermis muscle layer|hypodermal muscle layer|superficial fascia muscular layer	http://purl.obolibrary.org/obo/UBERON_0008876		pheno_slim
UBERON:0006210	biolink:AnatomicalEntity	body-wall mesenchyme		EHDAA:3217|EMAPA:16893|EHDAA2:0000179	hp.json		http://purl.obolibrary.org/obo/UBERON_0006210		emapa_ehdaa2
UBERON:0008878	biolink:AnatomicalEntity	palmar part of manus		NCIT:C33252|FMA:24920|UMLS:C0931849|galen:Palm	hp.json	palm of hand|palm|palmar region|front of hand|regio palmaris	http://purl.obolibrary.org/obo/UBERON_0008878		pheno_slim
CL:0008035	biolink:Cell	microcirculation associated smooth muscle cell			hp.json		http://purl.obolibrary.org/obo/CL_0008035		
UBERON:0006219	biolink:AnatomicalEntity	deltoid pre-muscle mass		EHDAA2:0000340|EMAPA:17749|EHDAA:6002	hp.json		http://purl.obolibrary.org/obo/UBERON_0006219		emapa_ehdaa2
UBERON:0006218	biolink:AnatomicalEntity	common atrial chamber		EMAPA:16342|EHDAA:1267|RETIRED_EHDAA2:0000268	hp.json		http://purl.obolibrary.org/obo/UBERON_0006218		emapa_ehdaa2
UBERON:0006217	biolink:AnatomicalEntity	cloacal membrane	The membrane that covers the embryonic cloaca, formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm; the urorectal septum joins the cloacal membrane and divides it into an anal membrane and a urogenital membrane; the point where the urorectal septum intersects the cloacal membrane is the future site of the perineal body; proliferation of mesoderm and ectoderm around the cloacal membrane produces primordial tissues of the external genitalia in both sexes: the genital tubercle, genital folds, and genital swellings.	EHDAA2:0000257|FMA:295525|UMLS:C0231056|EMAPA:16832|EHDAA:2933|VHOG:0001198|NCIT:C34128|EHDAA:214	hp.json	membrana cloacalis|embryonic cloacal membrane	http://purl.obolibrary.org/obo/UBERON_0006217		pheno_slim|emapa_ehdaa2
UBERON:0008870	biolink:AnatomicalEntity	pulmonary alveolar parenchyma	The distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages.	EMAPA:37942	hp.json		http://purl.obolibrary.org/obo/UBERON_0008870		human_reference_atlas|pheno_slim
UBERON:0006215	biolink:AnatomicalEntity	rhombic lip	The posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system.	ZFA:0001440|EHDAA2:0000231|EMAPA:17074|TAO:0001440|DHBA:10664|XAO:0004135	hp.json	rostral rhombic lip|cerebellum primordium|cerebellar anlage|presumptive cerebellum|cerebellar primordium|dorsal part of alar plate of metencephalon|future cerebellum	http://purl.obolibrary.org/obo/UBERON_0006215		pheno_slim|vertebrate_core
UBERON:0006214	biolink:AnatomicalEntity	carpus pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a carpal bone.	EHDAA2:0000222|VHOG:0000955|EHDAA:6324|EMAPA:17724	hp.json	carpal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0006214		
CL:0008034	biolink:Cell	mural cell	Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation.		hp.json		http://purl.obolibrary.org/obo/CL_0008034		added_for_HCA
UBERON:0006213	biolink:AnatomicalEntity	carpus cartilage element	A cartilaginous condensation that has the potential to develop into a carpal bone.	EHDAA2:0000221|EHDAA:8544|VHOG:0001123|EMAPA:18102	hp.json	carpal cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0006213		
UBERON:0008874	biolink:AnatomicalEntity	pulmonary acinus	The part of the airway consisting of a respiratory bronchiole and all of its branches.	EMAPA:37941|UMLS:C0225696|NCIT:C33426|FMA:7313	hp.json	arbor alveolaris|respiratory lobule|acinus pulmonaris|lobulus pulmonis primarius|primary pulmonary lobule	http://purl.obolibrary.org/obo/UBERON_0008874		pheno_slim|human_reference_atlas
GO:0031987	biolink:BiologicalProcess	locomotion involved in locomotory behavior	Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.		hp.json	locomotion during locomotory behaviour	http://purl.obolibrary.org/obo/GO_0031987		
HP:0025417	biolink:PhenotypicFeature	Patulous urethra	Urethra more open or expanded than normal.		hp.json		http://purl.obolibrary.org/obo/HP_0025417		
HP:0025418	biolink:PhenotypicFeature	Renal cortical necrosis	Patchy or diffuse ischemic destruction of all the elements of renal cortex resulting from significantly diminished renal arterial perfusion. Coagulative necrosis may be present, involving all tubular segments and glomeruli. Nuclei may be pale and pyknotic, or may no longer be apparent. Thrombi may be present in vessels at the edge of the infarct.		hp.json	Necrosis of the kidney cortex	http://purl.obolibrary.org/obo/HP_0025418		
HP:0025419	biolink:PhenotypicFeature	Pulmonary pneumatocele	A pneumatocele is a thin walled, gas-filled space in the lung. It is most frequently caused by acute pneumonia, trauma, or aspiration of hydrocarbon fluid and is usually transient. The mechanism is believed to be a combination of parenchymal necrosis and check-valve airway obstruction. A pneumatocele appears as an approximately round, thin-walled airspace in the lung.		hp.json	Pulmonary pneumatocoele	http://purl.obolibrary.org/obo/HP_0025419		
HP:0001449	biolink:PhenotypicFeature	Duplication of metatarsal bones		UMLS:C4025778	hp.json	Duplication of long bones of foot	http://purl.obolibrary.org/obo/HP_0001449		
HP:0001442	biolink:PhenotypicFeature	Somatic mosaicism	The presence of genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations.	UMLS:C1866227	hp.json		http://purl.obolibrary.org/obo/HP_0001442		
HP:0001443	biolink:PhenotypicFeature	Abnormality of the gluteal musculature		UMLS:C4025782	hp.json	Abnormality of glutes	http://purl.obolibrary.org/obo/HP_0001443		
HP:0025410	biolink:PhenotypicFeature	Splenogonadal fusion	Joining of the spleen and a gonad during embryological development.		hp.json		http://purl.obolibrary.org/obo/HP_0025410		
HP:0001440	biolink:PhenotypicFeature	Metatarsal synostosis		UMLS:C1862697	hp.json	Fusion of metatarsals|Fusion of the long bones of the feet|Synostosis involving metatarsal bones	http://purl.obolibrary.org/obo/HP_0001440		
HP:0001441	biolink:PhenotypicFeature	Abnormality of the musculature of the thigh		UMLS:C4025783	hp.json	Abnormal thigh muscles	http://purl.obolibrary.org/obo/HP_0001441		
HP:0001446	biolink:PhenotypicFeature	Abnormality of the musculature of the upper limbs		UMLS:C4025779	hp.json	Abnormal upper limb muscles	http://purl.obolibrary.org/obo/HP_0001446		
HP:0025413	biolink:PhenotypicFeature	Fossa navicularis urethral stricture	A type of urethral stricture affecting the fossa navicularis, which is the spongy part of the male urethra located at the glans penis.		hp.json		http://purl.obolibrary.org/obo/HP_0025413		
HP:0025414	biolink:PhenotypicFeature	Pendulous urethral stricture	A type of urethral stricture affecting the pendulous urethra, which is straight and fixed to the corpora cavernosa.		hp.json		http://purl.obolibrary.org/obo/HP_0025414		
HP:0001444	biolink:PhenotypicFeature	Autosomal dominant somatic cell mutation	Being related to a de novo variant that occurs in a single cell in developing somatic tissue. The cell is the progenitor of a population of identical mutant cells, all of which have descended from the cell that mutated. Clinical manifestations depend on the identity and proportion of affected cells in the body.	UMLS:C4025781	hp.json		http://purl.obolibrary.org/obo/HP_0001444		
HP:0025415	biolink:PhenotypicFeature	Bulbar urethral stricture	A type of urethral stricture affecting the bulbar urethra, which is the part of the urethra that traverses the root of the penis.		hp.json		http://purl.obolibrary.org/obo/HP_0025415		
HP:0001445	biolink:PhenotypicFeature	Abnormality of the hip-girdle musculature		UMLS:C4025780	hp.json		http://purl.obolibrary.org/obo/HP_0001445		
HP:0025416	biolink:PhenotypicFeature	Vaginal stricture	A narrowing of the vagina owing to scar formation.		hp.json		http://purl.obolibrary.org/obo/HP_0025416		
GO:0031982	biolink:CellularComponent	vesicle	Any small, fluid-filled, spherical organelle enclosed by membrane.	Wikipedia:Vesicle_(biology)|NIF_Subcellular:sao221389602	hp.json	membrane-bounded vesicle|membrane-enclosed vesicle	http://purl.obolibrary.org/obo/GO_0031982		goslim_pir
GO:0031981	biolink:CellularComponent	nuclear lumen	The volume enclosed by the nuclear inner membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0031981		
GO:0090289	biolink:BiologicalProcess	regulation of osteoclast proliferation	Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0090289		
GO:0090290	biolink:BiologicalProcess	positive regulation of osteoclast proliferation	Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0090290		
GO:0031975	biolink:CellularComponent	envelope	A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.		hp.json		http://purl.obolibrary.org/obo/GO_0031975		
GO:0090291	biolink:BiologicalProcess	negative regulation of osteoclast proliferation	Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0090291		
GO:0031974	biolink:CellularComponent	membrane-enclosed lumen	The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.		hp.json		http://purl.obolibrary.org/obo/GO_0031974		
HP:0025406	biolink:PhenotypicFeature	Asthenia	A state characterized by a feeling of weakness and loss of strength leading to a generalized weakness of the body.		hp.json	Lack of energy and strength|Prostration|Weakness	http://purl.obolibrary.org/obo/HP_0025406		
HP:0025407	biolink:PhenotypicFeature	Rectourethral fistula	An abnormal connection (fistula) between the rectum and the urethra.		hp.json	Urethrorectal fistula	http://purl.obolibrary.org/obo/HP_0025407		
HP:0001459	biolink:PhenotypicFeature	1-3 toe syndactyly	Syndactyly with fusion of toes one to three.	UMLS:C4025774	hp.json	Webbed 1st-3rd toes	http://purl.obolibrary.org/obo/HP_0001459		
HP:0025408	biolink:PhenotypicFeature	Abnormal spleen morphology	Any anomaly of the structure of the spleen.		hp.json	Splenic lesion	http://purl.obolibrary.org/obo/HP_0025408		
HP:0025409	biolink:PhenotypicFeature	Abnormal spleen physiology	Any anomaly of the function of the spleen.		hp.json		http://purl.obolibrary.org/obo/HP_0025409		
HP:0001454	biolink:PhenotypicFeature	Abnormality of the upper arm		UMLS:C4025776	hp.json		http://purl.obolibrary.org/obo/HP_0001454		
HP:0025400	biolink:PhenotypicFeature	Nodular-random pattern on pulmonary HRCT	A nodular pattern on pulmonary high-resolution computed tomography that has an apparently random pattern.		hp.json		http://purl.obolibrary.org/obo/HP_0025400		
HP:0025401	biolink:PhenotypicFeature	Staring gaze	An abnormality in which the eyes are held permanently wide open.		hp.json	Staring eyes	http://purl.obolibrary.org/obo/HP_0025401		
HP:0001452	biolink:PhenotypicFeature	obsolete Autosomal dominant contiguous gene syndrome			hp.json		http://purl.obolibrary.org/obo/HP_0001452		
HP:0001457	biolink:PhenotypicFeature	Abnormality of the musculature of the upper arm		UMLS:C4025775	hp.json		http://purl.obolibrary.org/obo/HP_0001457		
HP:0025402	biolink:PhenotypicFeature	Square-wave jerks	Square wave jerks are saccadic eye movements which, when recorded with open eyes are considered to be a pathological sign, caused by fixation instability, and pointing to a central neurological lesion.		hp.json		http://purl.obolibrary.org/obo/HP_0025402		
HP:0025403	biolink:PhenotypicFeature	Stooped posture	A habitual positioning of the body with the head and upper back bent forward.		hp.json		http://purl.obolibrary.org/obo/HP_0025403		
HP:0025404	biolink:PhenotypicFeature	Abnormal visual fixation	Any anomaly in the process of ocular fixation, which is the maintaining of the visual gaze on a single location.		hp.json		http://purl.obolibrary.org/obo/HP_0025404		
HP:0025405	biolink:PhenotypicFeature	Visual fixation instability	A deficit in the ability to fixate eye movements in order to stabilize images on the retina		hp.json	Instability of ocular fixation	http://purl.obolibrary.org/obo/HP_0025405		
HP:0001450	biolink:PhenotypicFeature	Y-linked inheritance	A mode of inheritance that is observed for traits related to a gene encoded on the Y chromosome.	UMLS:C0814045|MSH:D050173	hp.json	monoallelic_Y_hemizygous|Y-linked	http://purl.obolibrary.org/obo/HP_0001450		
GO:0090299	biolink:BiologicalProcess	regulation of neural crest formation	Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.		hp.json		http://purl.obolibrary.org/obo/GO_0090299		
GO:0031968	biolink:CellularComponent	organelle outer membrane	The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.		hp.json		http://purl.obolibrary.org/obo/GO_0031968		
GO:0031966	biolink:CellularComponent	mitochondrial membrane	Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.	NIF_Subcellular:sao1045389829	hp.json		http://purl.obolibrary.org/obo/GO_0031966		
GO:0031967	biolink:CellularComponent	organelle envelope	A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.		hp.json		http://purl.obolibrary.org/obo/GO_0031967		goslim_mouse
GO:0031965	biolink:CellularComponent	nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.	NIF_Subcellular:sao1687101204	hp.json		http://purl.obolibrary.org/obo/GO_0031965		
HP:0001428	biolink:PhenotypicFeature	Somatic mutation	A mode of inheritance in which a trait or disorder results from a de novo mutation occurring after conception, rather than being inherited from a preceding generation.	SNOMEDCT_US:124975008|UMLS:C0544886	hp.json		http://purl.obolibrary.org/obo/HP_0001428		
HP:0001426	biolink:PhenotypicFeature	Multifactorial inheritance	A mode of inheritance that depends on a mixture of major and minor genetic determinants possibly together with environmental factors. Diseases inherited in this manner are termed complex diseases.	UMLS:C0600599|MSH:D020412	hp.json	Familial predisposition	http://purl.obolibrary.org/obo/HP_0001426		
HP:0001427	biolink:PhenotypicFeature	Mitochondrial inheritance	A mode of inheritance that is observed for traits related to a gene encoded on the mitochondrial genome. Because the mitochondrial genome is essentially always maternally inherited, a mitochondrial condition can only be transmitted by females, although the condition can affect both sexes. The proportion of mutant mitochondria can vary (heteroplasmy).	UMLS:C0887941|MSH:D050259	hp.json	mitochondrial|Mitochondrial	http://purl.obolibrary.org/obo/HP_0001427		
HP:0001421	biolink:PhenotypicFeature	Abnormality of the musculature of the hand		UMLS:C4025786	hp.json	Abnormal hand muscles	http://purl.obolibrary.org/obo/HP_0001421		
HP:0001425	biolink:PhenotypicFeature	obsolete Heterogeneous			hp.json	Genetic heterogeneity	http://purl.obolibrary.org/obo/HP_0001425		
GO:0016325	biolink:BiologicalProcess	oocyte microtubule cytoskeleton organization	Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster.		hp.json	oocyte microtubule cytoskeleton organisation	http://purl.obolibrary.org/obo/GO_0016325		
HP:0001423	biolink:PhenotypicFeature	X-linked dominant inheritance	A mode of inheritance that is observed for dominant traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked dominant disorders tend to manifest very severely in affected males. The severity of manifestation in females may depend on the degree of skewed X inactivation.	UMLS:C1847879	hp.json	X-linked dominant	http://purl.obolibrary.org/obo/HP_0001423		
GO:0016321	biolink:BiologicalProcess	female meiosis chromosome segregation	The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female.		hp.json		http://purl.obolibrary.org/obo/GO_0016321		
HP:0001437	biolink:PhenotypicFeature	Abnormality of the musculature of the lower limbs		UMLS:C4025784	hp.json		http://purl.obolibrary.org/obo/HP_0001437		
HP:0001438	biolink:PhenotypicFeature	Abnormal abdomen morphology	A structural abnormality of the abdomen ('belly'), that is, the part of the body between the pelvis and the thorax.	UMLS:C4020869	hp.json	Abdomen abnormality|Abnormality of abdomen morphology|Abnormality of the abdomen|Abnormality of abdomen structure	http://purl.obolibrary.org/obo/HP_0001438		
CHEBI:53291	biolink:ChemicalSubstance	2-halophenol	A halophenol in which the halogen atom is bonded to the carbon atom adjacent to the C-OH group.		hp.json	2-halophenols	http://purl.obolibrary.org/obo/CHEBI_53291		3_STAR
HP:0001430	biolink:PhenotypicFeature	Abnormality of the calf musculature		UMLS:C4021779	hp.json	Abnormality of calf musculature|Abnormal calf muscles	http://purl.obolibrary.org/obo/HP_0001430		
HP:0001435	biolink:PhenotypicFeature	Abnormality of the shoulder girdle musculature		UMLS:C4021778	hp.json	Abnormality of shoulder musculature	http://purl.obolibrary.org/obo/HP_0001435		
HP:0001436	biolink:PhenotypicFeature	Abnormality of the foot musculature	An anomaly of the musculature of foot.	UMLS:C4025785	hp.json	Abnormal foot muscles	http://purl.obolibrary.org/obo/HP_0001436		
HP:0001433	biolink:PhenotypicFeature	Hepatosplenomegaly	Simultaneous enlargement of the liver and spleen.	SNOMEDCT_US:36760000|UMLS:C0019214	hp.json	Enlarged liver and spleen	http://purl.obolibrary.org/obo/HP_0001433		
GO:0090275	biolink:BiologicalProcess	negative regulation of somatostatin secretion	Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.		hp.json		http://purl.obolibrary.org/obo/GO_0090275		
GO:0090276	biolink:BiologicalProcess	regulation of peptide hormone secretion	Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.		hp.json		http://purl.obolibrary.org/obo/GO_0090276		
GO:0016331	biolink:BiologicalProcess	morphogenesis of embryonic epithelium	The process in which the anatomical structures of embryonic epithelia are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0016331		
GO:0090273	biolink:BiologicalProcess	regulation of somatostatin secretion	Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.		hp.json		http://purl.obolibrary.org/obo/GO_0090273		
GO:0090274	biolink:BiologicalProcess	positive regulation of somatostatin secretion	Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.		hp.json		http://purl.obolibrary.org/obo/GO_0090274		
CHEBI:507393	biolink:ChemicalSubstance	taurine zwitterion	The zwitterion formed from taurine by transfer of a proton from the sulfonyl to the amino group.  It is the major species existing at physiological pH.	PMID:17765547	hp.json	taurine|2-azaniumylethane-1-sulfonate|2-ammonioethanesulfonate	http://purl.obolibrary.org/obo/CHEBI_507393		3_STAR
GO:0090277	biolink:BiologicalProcess	positive regulation of peptide hormone secretion	Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.		hp.json		http://purl.obolibrary.org/obo/GO_0090277		
GO:0090278	biolink:BiologicalProcess	negative regulation of peptide hormone secretion	Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.		hp.json		http://purl.obolibrary.org/obo/GO_0090278		
GO:0031946	biolink:NamedThing	regulation of glucocorticoid biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0031946		
GO:0031947	biolink:NamedThing	negative regulation of glucocorticoid biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0031947		
GO:0031944	biolink:NamedThing	negative regulation of glucocorticoid metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0031944		
GO:0031945	biolink:NamedThing	positive regulation of glucocorticoid metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0031945		
GO:0031943	biolink:NamedThing	regulation of glucocorticoid metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0031943		
UBERON:0008817	biolink:AnatomicalEntity	thymus primordium endoderm	An endoderm that is part of a thymus primordium.		hp.json		http://purl.obolibrary.org/obo/UBERON_0008817		
GO:0031948	biolink:NamedThing	positive regulation of glucocorticoid biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0031948		
HP:0025453	biolink:PhenotypicFeature	Delayed adrenarche	Occurence of adrenarche at a later than normal age. Adrenarche normally occurs between six and eight years of age with increased adrenal androgen secretion; its exact biologic role is not well understood. It is accompanied by changes in pilosebaceous units, a transient growth spurt and the appearance of axillary and pubic hair in some children, but no sexual development.		hp.json		http://purl.obolibrary.org/obo/HP_0025453		
HP:0025454	biolink:PhenotypicFeature	Abnormal CSF metabolite concentration	Any deviation from the normal range of concentration of a metabolite in the cerebrospinal fluid.		hp.json	Abnormal cerebrospinal fluid metabolite concentration|Abnormal CSF metabolite level	http://purl.obolibrary.org/obo/HP_0025454		
HP:0001487	biolink:PhenotypicFeature	obsolete Hypopigmented fundi			hp.json		http://purl.obolibrary.org/obo/HP_0001487		
HP:0025455	biolink:PhenotypicFeature	Decreased CSF 5-hydroxyindolacetic acid	CSF 5-HIAA (5-hydroxyindolacetic acid) level is below the lower limit of normal.		hp.json	Decreased CSF 5-HIAA|Low CSF 5-HIAA|Low CSF 5-hydroxyindolacetic acid	http://purl.obolibrary.org/obo/HP_0025455		
UBERON:0008823	biolink:AnatomicalEntity	neural tube derived brain	A brain that develops_from a neural tube.		hp.json	vertebrate brain	http://purl.obolibrary.org/obo/UBERON_0008823		
HP:0025456	biolink:PhenotypicFeature	Abnormal CSF protein level	Any deviation from the normal range of a protein concentration in the cerebrospinal fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0025456		
UBERON:0008824	biolink:AnatomicalEntity	duct of epididymis	Any duct branching of of the main epididymis duct.	MA:0001735|UMLS:C0458632|FMA:18297|NCIT:C32484|EMAPA:36525	hp.json	epididymal duct|epididymis duct	http://purl.obolibrary.org/obo/UBERON_0008824		
GO:0016301	biolink:MolecularActivity	kinase activity	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.	Reactome:R-HSA-6788867|Reactome:R-HSA-6788855	hp.json	phosphokinase activity	http://purl.obolibrary.org/obo/GO_0016301		goslim_plant|goslim_drosophila|goslim_chembl|goslim_metagenomics|goslim_yeast
HP:0025457	biolink:PhenotypicFeature	Decreased CSF protein	CSF total protein level is below the lower limit of normal.		hp.json	Hypoproteinorrhachia|Decreased cerebrospinal fluid total protein|Low CSF total protein	http://purl.obolibrary.org/obo/HP_0025457		
HP:0025458	biolink:PhenotypicFeature	Decreased CSF albumin concentration	CSF albumin level is below the lower limit of normal.		hp.json	Low CSF albumin	http://purl.obolibrary.org/obo/HP_0025458		
HP:0025459	biolink:PhenotypicFeature	Increased CSF/serum albumin ratio	An increase above normal limits of the ratio of the cerebrospinal fluid (CSF) albumin concentration to serum albumin concentration.		hp.json		http://purl.obolibrary.org/obo/HP_0025459		
HP:0001488	biolink:PhenotypicFeature	Bilateral ptosis		UMLS:C1865916	hp.json	Drooping of both upper eyelids	http://purl.obolibrary.org/obo/HP_0001488		
HP:0001489	biolink:PhenotypicFeature	Posterior vitreous detachment	Separation of the vitreous humor from the retina.	SNOMEDCT_US:247081001|UMLS:C0423361|MSH:D020255	hp.json	Vitreous detachment	http://purl.obolibrary.org/obo/HP_0001489		
HP:0001482	biolink:PhenotypicFeature	Subcutaneous nodule	Slightly elevated lesions on or in the skin with a diameter of over 5 mm.	UMLS:C0151811|UMLS:C0746926|SNOMEDCT_US:95325000	hp.json	Growth of abnormal tissue under the skin|Firm lump under the skin|Nodule below the skin|Subcutaneous nodules|Multiple, subcutaneous nodules	http://purl.obolibrary.org/obo/HP_0001482		hposlim_core
HP:0001483	biolink:PhenotypicFeature	Eye poking	Repetitive pressing, poking, and/or rubbing in the eyes.	UMLS:C0233593|SNOMEDCT_US:78894008	hp.json	Oculodigital phenomenon|Ocular auto-stimulation	http://purl.obolibrary.org/obo/HP_0001483		
HP:0001480	biolink:PhenotypicFeature	Freckling	The presence of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin.	SNOMEDCT_US:403536009|SNOMEDCT_US:699225003|MSH:D008548|UMLS:C0016689	hp.json	Freckling	http://purl.obolibrary.org/obo/HP_0001480		
HP:0025451	biolink:PhenotypicFeature	Testicular adrenal rest tumor	Testicular adrenal rest tumor (TART) is a abenign tumor of the testis. TART generally occurs multiply and bilaterally within the rete testis. Histologically, TART resemble adrenocortical tissue, which led to the name. The tumous are not encapsulated and consist of sheets or confluent cords of large polygonal cells with abundant eosinophilic cytoplasm.		hp.json	Testicular adrenal rest tumour	http://purl.obolibrary.org/obo/HP_0025451		
HP:0025452	biolink:PhenotypicFeature	Pyoderma gangrenosum	A deep skin ulcer with a well defined border, which is usually violet or blue. The ulcer edge is often undermined (worn and damaged) and the surrounding skin is erythematous and indurated. The ulcer often starts as a small papule or collection of papules, which break down to form small ulcers with a so called cat's paw appearance. These coalesce and the central area then undergoes necrosis to form a single ulcer.		hp.json		http://purl.obolibrary.org/obo/HP_0025452		
GO:0006997	biolink:BiologicalProcess	nucleus organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.		hp.json	nuclear organization and biogenesis|nuclear organisation|nucleus organization and biogenesis|nuclear morphology|nuclear organization	http://purl.obolibrary.org/obo/GO_0006997		goslim_pir|goslim_aspergillus|goslim_drosophila|goslim_yeast|goslim_candida
GO:0004333	biolink:MolecularActivity	fumarate hydratase activity	Catalysis of the reaction: (S)-malate = fumarate + H(2)O.	MetaCyc:FUMHYDR-RXN|RHEA:12460|Reactome:R-HSA-451033|KEGG_REACTION:R01082|EC:4.2.1.2|Reactome:R-HSA-70982	hp.json	(S)-malate hydro-lyase activity|(S)-malate hydro-lyase (fumarate-forming)|L-malate hydro-lyase activity|fumarase activity	http://purl.obolibrary.org/obo/GO_0004333		
GO:0006998	biolink:BiologicalProcess	nuclear envelope organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.		hp.json	nuclear envelope organization and biogenesis|nuclear envelope organisation	http://purl.obolibrary.org/obo/GO_0006998		
GO:0006996	biolink:BiologicalProcess	organelle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.		hp.json	single-organism organelle organization|organelle organization and biogenesis|organelle organisation|single organism organelle organization	http://purl.obolibrary.org/obo/GO_0006996		goslim_pir|goslim_aspergillus|goslim_candida
UBERON:0008810	biolink:AnatomicalEntity	nasopalatine nerve	A branch of that maxillary nerve that innervates the mucous membrane of the hard palate.	BAMS:npal|FMA:52797	hp.json	Scarpa's nerve|naso-palatine nerve|nasopalatine nerves|nervus nasopalatinus|nasopalatine	http://purl.obolibrary.org/obo/UBERON_0008810		
HP:0001498	biolink:PhenotypicFeature	Carpal bone hypoplasia	Underdevelopment of one or more carpal bones.	UMLS:C4280594|UMLS:C1863749	hp.json	Hypoplastic carpal bones|Hypoplasia of carpal bones|Small carpal bones|Small wrist bones|Small carpals	http://purl.obolibrary.org/obo/HP_0001498		hposlim_core
HP:0025443	biolink:PhenotypicFeature	Abnormal cardiac atrial physiology	An abnormality of the function of the cardiac atria.		hp.json		http://purl.obolibrary.org/obo/HP_0025443		
UBERON:0008811	biolink:AnatomicalEntity	intromittent organ	An external organ of a male organism that is specialized to deliver sperm during copulation. Intromittent organs are found most often in terrestrial species, as most aquatic species fertilize their eggs externally, although there are exceptions[WP].	TGMA:0000585|FBbt:00004850|TAO:0002036|AAO:0010255|HAO:0000091	hp.json	aedeagus|penis|copulatory organ	http://purl.obolibrary.org/obo/UBERON_0008811		organ_slim|grouping_class
HP:0025444	biolink:PhenotypicFeature	Reduced amygdala volume	A decrease in the volume (size) of the amygdyla.		hp.json	Decrease in amygdala volume	http://purl.obolibrary.org/obo/HP_0025444		
HP:0001495	biolink:PhenotypicFeature	Carpal osteolysis	Osteolysis affecting carpal bones.	UMLS:C1833734	hp.json	Carpal bone osteolysis	http://purl.obolibrary.org/obo/HP_0001495		hposlim_core
HP:0025445	biolink:PhenotypicFeature	Morphological abnormality of the papillary muscles	Any structural anomaly of the papillary muscles of the left ventricle.		hp.json		http://purl.obolibrary.org/obo/HP_0025445		
HP:0025446	biolink:PhenotypicFeature	Anomalous insertion of papillary muscle directly into anterior mitral leaflet	A congenital malformation in which one or both of the papillary muscles (posteromedial or anterolateral) insert directly (that is, without interpositioned chordae tendineae) into the anterior mitral leaflet.		hp.json		http://purl.obolibrary.org/obo/HP_0025446		
HP:0025447	biolink:PhenotypicFeature	Displacement of the papillary muscles	Abnormal location of the insertion of a papillary muscle into the left ventricular wall.		hp.json		http://purl.obolibrary.org/obo/HP_0025447		
UBERON:0008814	biolink:AnatomicalEntity	pharyngeal arch system	A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified].	UMLS:C1519038|FMA:293041|NCIT:C34248|EHDAA2:0000187	hp.json	pharyngeal complex|pharyngeal system|pharyngeal arches and clefts|embryonic pharyngeal complex|pharyngeal arch region|pharyngeal apparatus|pharyngeal arch complex	http://purl.obolibrary.org/obo/UBERON_0008814		
HP:0025448	biolink:PhenotypicFeature	Anterior displacement of the papillary muscles	Abnormally anterior location of the papillary muscles of the left ventricle.		hp.json	Anteriorly displaced papillary muscles	http://purl.obolibrary.org/obo/HP_0025448		
UBERON:0008816	biolink:AnatomicalEntity	embryonic head	A head that is part of a embryo.	FMA:293011|CALOHA:TS-0246|FBbt:00000155	hp.json		http://purl.obolibrary.org/obo/UBERON_0008816		non_informative
HP:0025449	biolink:PhenotypicFeature	Apically displaced anterolateral papillary muscle	Abnormal location of the insertion of the anterolateral papillary muscle near to the apex of the left ventricle. This feature may be appreciated by noting that this muscle is usually not seen in the apical level of the parasternal short-axis echocardiographic view,		hp.json	Apically displaced papillary muscles	http://purl.obolibrary.org/obo/HP_0025449		
GO:0016310	biolink:BiologicalProcess	phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.	Wikipedia:Phosphorylation	hp.json		http://purl.obolibrary.org/obo/GO_0016310		goslim_chembl|goslim_metagenomics
GO:0016311	biolink:BiologicalProcess	dephosphorylation	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.	Wikipedia:Dephosphorylation	hp.json		http://purl.obolibrary.org/obo/GO_0016311		
HP:0001493	biolink:PhenotypicFeature	Falciform retinal fold	An area of the retina that is buckled so that a sector-shaped sheet of retina lies in front of the normal retina. This feature is of congenital onset.	SNOMEDCT_US:204181009|UMLS:C0344550	hp.json	Congenital retinal fold	http://purl.obolibrary.org/obo/HP_0001493		
HP:0025440	biolink:PhenotypicFeature	Warm reactive autoantibody positivity	Warm reactive autoantibodies are RBC-directed immune responses that are maximally reactive at 37 degrees C.		hp.json		http://purl.obolibrary.org/obo/HP_0025440		
HP:0001491	biolink:PhenotypicFeature	Congenital fibrosis of extraocular muscles	Congenital non-progressive ophthalmoplegia with multiple extraocular muscle restrictions. Typically, there is ptosis and variable degrees of restriction of horizontal and vertical eye movements.	MSH:C580012|UMLS:C1302995|SNOMEDCT_US:400946004	hp.json	Congenital fibrosis of the extraocular muscles|Congenital ophthalmoplegia|CFEOM	http://purl.obolibrary.org/obo/HP_0001491		hposlim_core
HP:0025441	biolink:PhenotypicFeature	Achilles tendon calcification	Ectopic deposition of calcium salts in the Achilles tendon.		hp.json	Calcification of the Achilles tendon	http://purl.obolibrary.org/obo/HP_0025441		
HP:0001492	biolink:PhenotypicFeature	Axenfeld anomaly	Axenfeld's anomaly is a bilateral disorder characterized by a prominent, anteriorly displaced Schwalbe's line (posterior embryotoxon) and peripheral iris strands which span the anterior chamber angle to attach to Schwalbe's line.	UMLS:C0266548|MSH:C535679|SNOMEDCT_US:204152008	hp.json		http://purl.obolibrary.org/obo/HP_0001492		hposlim_core
HP:0025439	biolink:PhenotypicFeature	Pharyngitis	Inflammation (due to infection or irritation) of the pharynx.		hp.json		http://purl.obolibrary.org/obo/HP_0025439		
CHEBI:65212	biolink:ChemicalSubstance	polysaccharide derivative	A carbohydrate derivative that is any derivative of a polysaccharide.		hp.json	polysaccharide derivatives	http://purl.obolibrary.org/obo/CHEBI_65212		3_STAR
HP:0001464	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the shoulder musculature	Absence or underdevelopment of the muscles of the shoulder.	UMLS:C4025772	hp.json	Absent/small shoulder muscles|Absent/underdeveloped shoulder muscles	http://purl.obolibrary.org/obo/HP_0001464		
HP:0025431	biolink:PhenotypicFeature	Staccato cry	A type of cry that is abnormal because it is consists of unusually shortened and detached vocalizations.		hp.json		http://purl.obolibrary.org/obo/HP_0025431		
HP:0001465	biolink:PhenotypicFeature	Amyotrophy involving the shoulder musculature		UMLS:C4025771	hp.json	Shoulder muscle degeneration|Wasting of shoulder muscles	http://purl.obolibrary.org/obo/HP_0001465		
HP:0025432	biolink:PhenotypicFeature	Acanthoma	A benign epithelial skin tumor manifesting as a slightly elevated circular plaque or nodule with a red, pink or brown color and a diameter up to 22 mm.		hp.json		http://purl.obolibrary.org/obo/HP_0025432		
HP:0025433	biolink:PhenotypicFeature	Decreased lecithin cholesterol acyl transferase level	Reduced level of the enzyme lecithin cholesterol acyl transferase.		hp.json		http://purl.obolibrary.org/obo/HP_0025433		
UBERON:0008801	biolink:AnatomicalEntity	parotid gland primordium		EHDAA:9246|EHDAA2:0001413	hp.json		http://purl.obolibrary.org/obo/UBERON_0008801		
HP:0025434	biolink:PhenotypicFeature	Reduced hemolytic complement activity	A diminished activity of the classical complement pathway as measured by the assay for 50% haemolytic complement (CH50) activity of serum.		hp.json	Reduced CH50	http://purl.obolibrary.org/obo/HP_0025434		
HP:0025435	biolink:PhenotypicFeature	Increased circulating lactate dehydrogenase concentration	An elevated level of the enzyme lactate dehydrogenase in the blood circulation.		hp.json	Increased lactate dehydrogenase level	http://purl.obolibrary.org/obo/HP_0025435		
HP:0001468	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the musculature of the upper arm	Absence or underdevelopment of the muscles of the upper arm.	UMLS:C4025769	hp.json	Absent/small upper arm muscles|Absent/underdeveloped upper arm muscles	http://purl.obolibrary.org/obo/HP_0001468		
HP:0001469	biolink:PhenotypicFeature	Abnormal morphology of the pelvis musculature		UMLS:C4025768	hp.json	Abnormality of the musculature of the pelvis	http://purl.obolibrary.org/obo/HP_0001469		
HP:0025436	biolink:PhenotypicFeature	Elevated serum 11-deoxycortisol	Increased concentration of 11-deoxycortisol in the circulation. 11-deoxycorticosterone, which is also known as simply deoxycorticosterone and 21-hydroxyprogesterone, is a steroid hormore that is produces in the adrenals and is a precursor to aldosterone.		hp.json	Elevated serum deoxycorticosterone|Elevated serum 21-hydroxyprogesterone	http://purl.obolibrary.org/obo/HP_0025436		
UBERON:0008803	biolink:AnatomicalEntity	skin of cheek	A zone of skin that is part of a cheek.	FMA:24759	hp.json	cheek skin	http://purl.obolibrary.org/obo/UBERON_0008803		pheno_slim
HP:0001466	biolink:PhenotypicFeature	Contiguous gene syndrome	A syndrome caused by the effects of abnormality (typically a deletion or duplication) of 2 or more adjacent genes	UMLS:C1855496	hp.json		http://purl.obolibrary.org/obo/HP_0001466		
HP:0025437	biolink:PhenotypicFeature	Macrocephalic sperm head	Increased size of the head of sperm.		hp.json		http://purl.obolibrary.org/obo/HP_0025437		
UBERON:0008805	biolink:AnatomicalEntity	gingival groove	The gingival sulcus is an area of potential space between a tooth and the surrounding gingival tissue and is lined by sulcular epithelium. The depth of the sulcus (Latin for groove) is bounded by two entities: apically by the gingival fibers of the connective tissue attachment and coronally by the free gingival margin.	FMA:74580|NCIT:C114645	hp.json	gingival sulcus|sulcus gingivalis|sulcus gingivalis|tooth-gingiva interface	http://purl.obolibrary.org/obo/UBERON_0008805		
HP:0001467	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the musculature of the upper limbs	Absence or underdevelopment of the musculature of the upper limbs.	UMLS:C4025770	hp.json	Absent/small upper limb muscles|Absent/underdeveloped upper limb muscles	http://purl.obolibrary.org/obo/HP_0001467		
HP:0001460	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the skeletal musculature	Absence or underdevelopment of the musculature.	UMLS:C4025773	hp.json	Absent/small skeletal muscles|Absent/underdeveloped skeletal muscles	http://purl.obolibrary.org/obo/HP_0001460		
HP:0025430	biolink:PhenotypicFeature	High-pitched cry	A type of crying in an abnormally high-pitched voice.		hp.json		http://purl.obolibrary.org/obo/HP_0025430		
GO:0006974	biolink:BiologicalProcess	cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.		hp.json	DNA damage response|cellular DNA damage response|response to genotoxic stress|response to DNA damage stimulus	http://purl.obolibrary.org/obo/GO_0006974		goslim_yeast
HP:0025428	biolink:PhenotypicFeature	Bronchospasm	A spasm (sudden, involuntary constriction) of the bronchioles.		hp.json		http://purl.obolibrary.org/obo/HP_0025428		
HP:0025429	biolink:PhenotypicFeature	Abnormal cry	Any anomaly of the vocalizing of an infant's crying, i.e.,the typically loud voice production that is accompanied by tears and agitation.		hp.json		http://purl.obolibrary.org/obo/HP_0025429		
HP:0025420	biolink:PhenotypicFeature	Diffuse alveolar hemorrhage	A type of of pulmonary hemorrhage that originates from the pulmonary microcirculation, including the alveolar capillaries, arterioles, and venules. It presents with hemoptysis, anemia, diffuse lung infiltration, and acute respiratory failure. The diagnosis is confirmed by the observation of the accumulation of red blood cells, fibrin, or hemosiderin-laden macrophage in the alveolar space on pathologic biopsy. Hemosiderin, a product of hemoglobin degradation, appears at least 48-72 hours after bleeding and is helpful in distinguishing diffuse alveolar hemorrhage from surgical trauma. Mild interstitial thickening, organizing pneumonia, or diffuse alveolar damage can also be seen.		hp.json	Diffuse alveolar haemorrhage	http://purl.obolibrary.org/obo/HP_0025420		
HP:0001475	biolink:PhenotypicFeature	Male-limited expression	Used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in the male sex.	UMLS:C4025764	hp.json		http://purl.obolibrary.org/obo/HP_0001475		
HP:0001476	biolink:PhenotypicFeature	Delayed closure of the anterior fontanelle	A delay in closure (ossification) of the anterior fontanelle, which generally undergoes closure around the 18th month of life.	SNOMEDCT_US:295091000119100|UMLS:C4072831|UMLS:C3840083	hp.json	Delayed closure anterior fontanel|Delayed closure of the soft spot on the skull|Late closure of the bregma sutures|Late closure of anterior fontanelle|Delayed closure of the bregma sutures|Delayed closure of anterior fontanelle|Late closure of large anterior fontanel|Persistent anterior fontanelle|Late closure of soft spot on the skull|Later than typical closing of soft spot of skull	http://purl.obolibrary.org/obo/HP_0001476		
HP:0025421	biolink:PhenotypicFeature	Pneumomediastinum	The presence of free air in the mediastinum.		hp.json		http://purl.obolibrary.org/obo/HP_0025421		
HP:0001473	biolink:PhenotypicFeature	Metatarsal osteolysis	Osteolysis involving metatarsal bones.	UMLS:C1854614	hp.json	Osteolysis involving metatarsal bones	http://purl.obolibrary.org/obo/HP_0001473		
HP:0025422	biolink:PhenotypicFeature	Pleural cyst	A closed sac-like structure originating from the pleura that contains a liquid, gaseous, or semisolid substance.		hp.json		http://purl.obolibrary.org/obo/HP_0025422		
GO:0018958	biolink:BiologicalProcess	phenol-containing compound metabolic process	The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.	UM-BBD_pathwayID:phe	hp.json	hydroxybenzene metabolism|carbolic acid metabolic process|phenol-containing compound metabolism|carbolic acid metabolism|hydroxybenzene metabolic process	http://purl.obolibrary.org/obo/GO_0018958		
HP:0025423	biolink:PhenotypicFeature	Abnormal larynx morphology	Any anomaly of the structure of the larynx.		hp.json		http://purl.obolibrary.org/obo/HP_0025423		
HP:0001474	biolink:PhenotypicFeature	Sclerotic scapulae	Increased density of the bony tissue of the scapula.	UMLS:C1849263	hp.json		http://purl.obolibrary.org/obo/HP_0001474		hposlim_core
HP:0025424	biolink:PhenotypicFeature	Abnormal larynx physiology	Any anomaly of the function of the larynx.		hp.json		http://purl.obolibrary.org/obo/HP_0025424		
HP:0025425	biolink:PhenotypicFeature	Laryngospasm	A spasm (involuntary contraction) of the vocal cords that can make it difficult to speak or breathe.		hp.json		http://purl.obolibrary.org/obo/HP_0025425		
HP:0001477	biolink:PhenotypicFeature	Compensatory chin elevation	A tendency to hold the chin elevated by about 20 to 30 degrees to compensate for a limitation of eye movement.	UMLS:C1846911	hp.json	Compensatory head tilt/chin elevation	http://purl.obolibrary.org/obo/HP_0001477		
HP:0025426	biolink:PhenotypicFeature	Abnormal bronchus morphology	Any structural anomaly of the bronchi, i.e., of the airways leading from the trachea to the lungs.		hp.json	Abnormality of the bronchi	http://purl.obolibrary.org/obo/HP_0025426		
HP:0025427	biolink:PhenotypicFeature	Abnormal bronchus physiology	Any anomaly of the function of the bronchi.		hp.json		http://purl.obolibrary.org/obo/HP_0025427		
HP:0001471	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the musculature of the pelvis		UMLS:C4025766	hp.json	Absent/small pelvis muscles|Absent/underdeveloped pelvis muscles	http://purl.obolibrary.org/obo/HP_0001471		
HP:0001472	biolink:PhenotypicFeature	obsolete Familial predisposition			hp.json		http://purl.obolibrary.org/obo/HP_0001472		
HP:0001470	biolink:PhenotypicFeature	Sex-limited expression	Sex limitation is used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in one sex.	UMLS:C4025767	hp.json		http://purl.obolibrary.org/obo/HP_0001470		
HP:0001604	biolink:PhenotypicFeature	Vocal cord paresis	Decreased strength of the vocal folds.	SNOMEDCT_US:445424004|SNOMEDCT_US:302912005|UMLS:C0751576|MSH:D014826|UMLS:C1843187|UMLS:C1853729|UMLS:C1832690	hp.json	Weakness of the vocal cords|Hoarse voice due to vocal cord paresis|Vocal cord paresis in severe cases	http://purl.obolibrary.org/obo/HP_0001604		
OBI:0002600	biolink:NamedThing	collecting specimen with swab	A specimen collection process that uses a swab as the collection device. A swab is an absorbent material (e.g. cotton) on a rod (e.g., wooden stick).		hp.json		http://purl.obolibrary.org/obo/OBI_0002600		
HP:0001605	biolink:PhenotypicFeature	Vocal cord paralysis	A loss of the ability to move the vocal folds.	SNOMEDCT_US:302912005|UMLS:C0042928|UMLS:C1854345|MSH:D014826	hp.json	Inability to move vocal cords|Laryngeal paralysis	http://purl.obolibrary.org/obo/HP_0001605		
HP:0001602	biolink:PhenotypicFeature	Laryngeal stenosis	Stricture or narrowing of the larynx that may be associated with symptoms of respiratory difficulty depending on the degree of laryngeal narrowing.	UMLS:C0023075|MSH:D007829|SNOMEDCT_US:75547007	hp.json		http://purl.obolibrary.org/obo/HP_0001602		
HP:0001608	biolink:PhenotypicFeature	Abnormality of the voice		UMLS:C4021776	hp.json	Voice abnormality|Abnormality of the voice	http://purl.obolibrary.org/obo/HP_0001608		
HP:0001609	biolink:PhenotypicFeature	Hoarse voice	Hoarseness refers to a change in the pitch or quality of the voice, with the voice sounding weak, very breathy, scratchy, or husky.	SNOMEDCT_US:50219008|UMLS:C0019825|MSH:D006685|UMLS:C1854348	hp.json	Husky voice|Hoarseness|Hoarse voice	http://purl.obolibrary.org/obo/HP_0001609		
HP:0001606	biolink:PhenotypicFeature	obsolete Vocal cord paralysis (caused by tumor impingement)			hp.json		http://purl.obolibrary.org/obo/HP_0001606		
HP:0001607	biolink:PhenotypicFeature	Subglottic stenosis		SNOMEDCT_US:22668006|UMLS:C0238441	hp.json		http://purl.obolibrary.org/obo/HP_0001607		
HP:0001600	biolink:PhenotypicFeature	Abnormality of the larynx	An abnormality of the larynx.	UMLS:C4021777	hp.json	Laryngeal anomalies|Laryngeal abnormalities	http://purl.obolibrary.org/obo/HP_0001600		
HP:0001601	biolink:PhenotypicFeature	Laryngomalacia	Laryngomalacia is a congenital abnormality of the laryngeal cartilage in which the cartilage is floppy and prolapses over the larynx during inspiration.	MSH:D055092|SNOMEDCT_US:38086007|UMLS:C0264303	hp.json	Softening of voice box tissue	http://purl.obolibrary.org/obo/HP_0001601		
HP:0001615	biolink:PhenotypicFeature	Hoarse cry		UMLS:C2678303	hp.json	Hoarse cry	http://purl.obolibrary.org/obo/HP_0001615		
HP:0001613	biolink:PhenotypicFeature	obsolete Hoarse voice (caused by tumor impingement)			hp.json		http://purl.obolibrary.org/obo/HP_0001613		
HP:0001618	biolink:PhenotypicFeature	Dysphonia	An impairment in the ability to produce voice sounds.	SNOMEDCT_US:47004009|MSH:D055154|UMLS:C1527344	hp.json	Inability to produce voice sounds|Voice change	http://purl.obolibrary.org/obo/HP_0001618		
HP:0001611	biolink:PhenotypicFeature	Nasal speech	A type of speech characterized by the presence of an abnormally increased nasal airflow during speech.	UMLS:C0454555|SNOMEDCT_US:289190003|UMLS:C0566620|SNOMEDCT_US:229645001	hp.json	Hypernasal speech|Nasal voice|Hypernasal voice|Nasal speech	http://purl.obolibrary.org/obo/HP_0001611		
HP:0001612	biolink:PhenotypicFeature	Weak cry		UMLS:C0234860|SNOMEDCT_US:2120003	hp.json		http://purl.obolibrary.org/obo/HP_0001612		
NCBITaxon:314145	biolink:OrganismalEntity	Laurasiatheria			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_314145		
NCBITaxon:314146	biolink:OrganismalEntity	Euarchontoglires		PMID:15522813|PMID:11214319|PMID:12878460|GC_ID:1|PMID:12082125	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_314146		
NCBITaxon:314147	biolink:OrganismalEntity	Glires		PMID:15522813|PMID:11214319|GC_ID:1|PMID:12082125	hp.json	Rodents and rabbits	http://purl.obolibrary.org/obo/NCBITaxon_314147		
PR:P13379	biolink:Protein	T-cell surface glycoprotein CD5 (mouse)	A T-cell surface glycoprotein CD5 that is encoded in the genome of mouse.	UniProtKB:P13379	hp.json	CD5 (mouse)|Cd5|Ly-1|lymphocyte antigen 1 (mouse)|Lyt-1 (mouse)|mCD5	http://purl.obolibrary.org/obo/PR_P13379		
GO:1905038	biolink:BiologicalProcess	regulation of membrane lipid metabolic process	Any process that modulates the frequency, rate or extent of membrane lipid metabolic process.		hp.json	regulation of membrane lipid metabolism	http://purl.obolibrary.org/obo/GO_1905038		
GO:0090435	biolink:BiologicalProcess	protein localization to nuclear envelope	A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.		hp.json	protein localization in nuclear envelope	http://purl.obolibrary.org/obo/GO_0090435		
GO:1905039	biolink:BiologicalProcess	carboxylic acid transmembrane transport	The process in which carboxylic acid is transported across a membrane.		hp.json		http://purl.obolibrary.org/obo/GO_1905039		
HP:0025615	biolink:PhenotypicFeature	Abscess			hp.json		http://purl.obolibrary.org/obo/HP_0025615		
HP:0001648	biolink:PhenotypicFeature	Cor pulmonale	Right-sided heart failure resulting from chronic hypertension in the pulmonary arteries and right ventricle.	UMLS:C0034072|SNOMEDCT_US:274096000|MSH:D011660|SNOMEDCT_US:83291003	hp.json		http://purl.obolibrary.org/obo/HP_0001648		
HP:0025616	biolink:PhenotypicFeature	Sterile abscess	An abscess not caused by infection with pyogenic bacteria. Operationally, a sterile abscess is inferred if investigations of an abscess fail to reveal evidence of pathogenic organisms.		hp.json		http://purl.obolibrary.org/obo/HP_0025616		
HP:0001649	biolink:PhenotypicFeature	Tachycardia	A rapid heartrate that exceeds the range of the normal resting heartrate for age.	UMLS:C4020868|SNOMEDCT_US:86651002|UMLS:C0039231|SNOMEDCT_US:3424008|MSH:D013610	hp.json	Racing heart|Increased heart rate|Rapid heart beat|Fast heart rate|Elevated heart rate|Heart racing	http://purl.obolibrary.org/obo/HP_0001649		
HP:0001646	biolink:PhenotypicFeature	Abnormal aortic valve morphology	Any abnormality of the aortic valve.	Fyler:1400|UMLS:C3164445|Fyler:1408|SNOMEDCT_US:448743001	hp.json	Abnormality of the aortic valve	http://purl.obolibrary.org/obo/HP_0001646		
HP:0025617	biolink:PhenotypicFeature	Abnormal plasma cell count	An abnormal number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies.		hp.json		http://purl.obolibrary.org/obo/HP_0025617		
HP:0001647	biolink:PhenotypicFeature	Bicuspid aortic valve	The presence of an aortic valve with two instead of the normal three cusps (flaps). Bicuspid aortic valvue is a malformation of a commissure (small space between the attachment of each cusp to the aortic wall) and the adjacent parts of the two corresponding cusps forming a raphe (the fused area of the two underdeveloped cusps turning into a malformed commissure between both cusps; the raphe is a fibrous ridge that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps).	UMLS:C0149630|MSH:C562388|SNOMEDCT_US:72352009	hp.json	Aortic valve has two leaflets rather than three	http://purl.obolibrary.org/obo/HP_0001647		
HP:0025618	biolink:PhenotypicFeature	Reduced plasma cell count	An abnormally low number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies.		hp.json		http://purl.obolibrary.org/obo/HP_0025618		
HP:0025619	biolink:PhenotypicFeature	Elevated plasma cell count	An abnormally high number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies.		hp.json		http://purl.obolibrary.org/obo/HP_0025619		
HP:0001640	biolink:PhenotypicFeature	Cardiomegaly	Increased size of the heart, clinically defined as an increased transverse diameter of the cardiac silhouette that is greater than or equal to 50% of the transverse diameter of the chest (increased cardiothoracic ratio) on a posterior-anterior projection of a chest radiograph or a computed tomography.	SNOMEDCT_US:8186001|UMLS:C0018800|MSH:D006332	hp.json	Increased heart size|Enlarged heart	http://purl.obolibrary.org/obo/HP_0001640		
HP:0001641	biolink:PhenotypicFeature	Abnormal pulmonary valve morphology	Any structural abnormality of the pulmonary valve.	SNOMEDCT_US:448643005|UMLS:C3164374|Fyler:1602|Fyler:1600	hp.json	Abnormality of the pulmonary valve|Anomaly of the pulmonary valve	http://purl.obolibrary.org/obo/HP_0001641		
HP:0025610	biolink:PhenotypicFeature	Posterior blepharitis	A type of blepharitis that affects the meibomian glands and meobomian gland orifices. This abnormality can be associated with a spectrum of appearances ranging from meibomian seborrhoea (foaming meibomian gland secretions) and meibomianitis (inflamed meibomian glands), to chalazia.		hp.json	Meibomian gland disease|Meibomian gland dysfunction	http://purl.obolibrary.org/obo/HP_0025610		
HP:0001644	biolink:PhenotypicFeature	Dilated cardiomyopathy	Dilated cardiomyopathy (DCM) is defined by the presence of left ventricular dilatation and left ventricular systolic dysfunction in the absence of abnormal loading conditions (hypertension, valve disease) or coronary artery disease sufficient to cause global systolic impairment. Right ventricular dilation and dysfunction may be present but are not necessary for the diagnosis.	MSH:D002311|SNOMEDCT_US:195021004|UMLS:C0007193|Fyler:1843|SNOMEDCT_US:399020009	hp.json	DCM|Stretched and thinned heart muscle|Congestive cardiomyopathy|Cardiomyopathy, dilated	http://purl.obolibrary.org/obo/HP_0001644		
HP:0025611	biolink:PhenotypicFeature	Epicanthus superciliaris	A type of epicanthus in which more extensive epicanthal folds with their origins in the eyebrow cover, pass in front of and lateral to the medial canthus (middle corner of the eye).		hp.json		http://purl.obolibrary.org/obo/HP_0025611		
HP:0001645	biolink:PhenotypicFeature	Sudden cardiac death	The heart suddenly and unexpectedly stops beating resulting in death within a short time period (generally within 1 h of symptom onset).	MSH:D016757|SNOMEDCT_US:95281009|UMLS:C0085298	hp.json	Premature sudden cardiac death|Sudden cardiac death	http://purl.obolibrary.org/obo/HP_0001645		
HP:0025612	biolink:PhenotypicFeature	Corneal astigmatism	A type of refractive error related abnormal curvatures on the anterior or posterior surface of the cornea.		hp.json		http://purl.obolibrary.org/obo/HP_0025612		
HP:0001642	biolink:PhenotypicFeature	Pulmonic stenosis	A narrowing of the right ventricular outflow tract that can occur at the pulmonary valve (valvular stenosis), below the pulmonary valve (infundibular stenosis), or above the pulmonary valve (supravalvar stenosis).	UMLS:C1956257|SNOMEDCT_US:56786000|MSH:D011666|Fyler:1611	hp.json	Pulmonary valve stenosis|Pulmonary stenosis|Pulmonic valve stenosis|Narrowing of pulmonic valve	http://purl.obolibrary.org/obo/HP_0001642		
HP:0025613	biolink:PhenotypicFeature	Focal emotional seizure	Seizures presenting with an emotion or the appearance of having an emotion as an early prominent feature, such as fear, spontaneous joy or euphoria, laughing (gelastic), or crying, (dacrystic). These emotional seizures may occur with or without objective clinical signs of a seizure evident to the observer.		hp.json	Affective seizure|Focal affective seizure|Partial emotional seizure|Emotional seizure	http://purl.obolibrary.org/obo/HP_0025613		
HP:0001643	biolink:PhenotypicFeature	Patent ductus arteriosus	In utero, the ductus arteriosus (DA) serves to divert ventricular output away from the lungs and toward the placenta by connecting the main pulmonary artery to the descending aorta. A patent ductus arteriosus (PDA) in the first 3 days of life is a physiologic shunt in healthy term and preterm newborn infants, and normally is substantially closed within about 24 hours after bith and completely closed after about three weeks. Failure of physiologcal closure is referred to a persistent or patent ductus arteriosus (PDA). Depending on the degree of left-to-right shunting, PDA can have clinical consequences.	UMLS:C0013274|Fyler:2100|SNOMEDCT_US:83330001|MSH:D004374	hp.json	Patent ductus Botalli|PDA|Persistent arterial duct|Persistent ductus arteriosus|Ductus arteriosus	http://purl.obolibrary.org/obo/HP_0001643		
HP:0025604	biolink:PhenotypicFeature	Orbital schwannoma	A schwannoma (benign, usually encapsulated slow growing tumor composed of Schwann cells) located in the orbit.		hp.json		http://purl.obolibrary.org/obo/HP_0025604		
HP:0001659	biolink:PhenotypicFeature	Aortic regurgitation	An insufficiency of the aortic valve, leading to regurgitation (backward flow) of blood from the aorta into the left ventricle.	UMLS:C0003504|SNOMEDCT_US:60234000|MSH:D001022	hp.json	Aortic insufficiency|Aortic valve regurgitation	http://purl.obolibrary.org/obo/HP_0001659		
GO:1905063	biolink:BiologicalProcess	regulation of vascular associated smooth muscle cell differentiation	Any process that modulates the frequency, rate or extent of vascular smooth muscle cell differentiation.		hp.json	regulation of VSMC differentiation|regulation of vascular smooth muscle cell differentiation	http://purl.obolibrary.org/obo/GO_1905063		
HP:0025605	biolink:PhenotypicFeature	Lid lag on downgaze	Delayed descent of the upper eyelid on downgaze. Also described by some authors as von Graefe sign.		hp.json	Lid lag|Eyelid lag|von Graefe sign	http://purl.obolibrary.org/obo/HP_0025605		
GO:1905064	biolink:BiologicalProcess	negative regulation of vascular associated smooth muscle cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.		hp.json	downregulation of vascular smooth muscle cell differentiation|down regulation of VSMC differentiation|inhibition of VSMC differentiation|down-regulation of VSMC differentiation|negative regulation of VSMC differentiation|downregulation of vascular associated smooth muscle cell differentiation|negative regulation of vascular smooth muscle cell differentiation|down-regulation of vascular smooth muscle cell differentiation|down regulation of vascular associated smooth muscle cell differentiation|inhibition of vascular associated smooth muscle cell differentiation|down regulation of vascular smooth muscle cell differentiation|down-regulation of vascular associated smooth muscle cell differentiation|downregulation of VSMC differentiation|inhibition of vascular smooth muscle cell differentiation	http://purl.obolibrary.org/obo/GO_1905064		
HP:0001657	biolink:PhenotypicFeature	Prolonged QT interval	Increased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).	UMLS:C0151878|SNOMEDCT_US:111975006	hp.json	Prolong qt interval on ekg|Long QT syndrome|Long Q-T syndrome	http://purl.obolibrary.org/obo/HP_0001657		
HP:0025606	biolink:PhenotypicFeature	Abnormal medial rectus muscle physiology	A functional anomaly of the medial rectus muscle, an extraocular muscle that is innervated by the inferior division of the oculomotor nerve and whose sole action is the adduction of the eyeball.		hp.json		http://purl.obolibrary.org/obo/HP_0025606		
GO:1905065	biolink:BiologicalProcess	positive regulation of vascular associated smooth muscle cell differentiation	Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation.		hp.json	activation of VSMC differentiation|up-regulation of vascular smooth muscle cell differentiation|up regulation of vascular smooth muscle cell differentiation|up regulation of vascular associated smooth muscle cell differentiation|positive regulation of vascular smooth muscle cell differentiation|activation of vascular smooth muscle cell differentiation|upregulation of VSMC differentiation|up-regulation of vascular associated smooth muscle cell differentiation|activation of vascular associated smooth muscle cell differentiation|upregulation of vascular smooth muscle cell differentiation|positive regulation of VSMC differentiation|up regulation of VSMC differentiation|upregulation of vascular associated smooth muscle cell differentiation|up-regulation of VSMC differentiation	http://purl.obolibrary.org/obo/GO_1905065		
HP:0001658	biolink:PhenotypicFeature	Myocardial infarction	Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin.	UMLS:C0027051|SNOMEDCT_US:22298006|MSH:D009203	hp.json	MI|Heart attack	http://purl.obolibrary.org/obo/HP_0001658		
HP:0025607	biolink:PhenotypicFeature	Upper eyelid entropion	An inward turning (inversion) of the margin of the upper eyelid.		hp.json		http://purl.obolibrary.org/obo/HP_0025607		
HP:0025608	biolink:PhenotypicFeature	Cicatricial ectropion	An outward turning (eversion) or rotation of the eyelid margin (i.e., ectropion) caused by shortening or contraction of the anterior or middle lamellae related to scarring.		hp.json		http://purl.obolibrary.org/obo/HP_0025608		
HP:0025609	biolink:PhenotypicFeature	Anterior blepharitis	A type of blepharitis that affects the eyelid skin, base of the eyelashes, and the eyelash follicles.		hp.json		http://purl.obolibrary.org/obo/HP_0025609		
GO:1905069	biolink:BiologicalProcess	allantois development	The process whose specific outcome is the progression of an allantois over time, from its formation to the mature structure.		hp.json	allantoic bud development	http://purl.obolibrary.org/obo/GO_1905069		
HP:0001651	biolink:PhenotypicFeature	Dextrocardia	The heart is located in the right hand sided hemithorax. That is, there is a left-right reversal (or "mirror reflection") of the anatomical location of the heart in which the heart is locate on the right side instead of the left.	UMLS:C0011813|EPCC:02.01.02|SNOMEDCT_US:27637000|ICD-10:Q24.0|Fyler:110|MSH:D003914|Fyler:0110	hp.json	Thoracic situs inversus|Heart tip and four chambers point towards right side of body	http://purl.obolibrary.org/obo/HP_0001651		
HP:0001650	biolink:PhenotypicFeature	Aortic valve stenosis	The presence of a stenosis (narrowing) of the aortic valve.	SNOMEDCT_US:60573004|UMLS:C0003507|MSH:D001024|Fyler:1411	hp.json	Narrowing of aortic valve|Aortic stenosis|Valvular aortic stenosis	http://purl.obolibrary.org/obo/HP_0001650		
HP:0001655	biolink:PhenotypicFeature	Patent foramen ovale	Failure of the foramen ovale to seal postnatally, leaving a potential conduit between the left and right cardiac atria.	Fyler:2020|SNOMEDCT_US:204317008|ICD-10:Q21.1|UMLS:C0016522|MSH:D054092	hp.json	Persistent foramen ovale	http://purl.obolibrary.org/obo/HP_0001655		
HP:0025600	biolink:PhenotypicFeature	Abnormal inferior rectus muscle physiology	A functional anomaly of the inferior rectus muscle, which is innervated by the inferior division of oculomotor nerve and functions in the depression, adduction, and lateral rotation (extortion) of the eye.		hp.json		http://purl.obolibrary.org/obo/HP_0025600		
HP:0025601	biolink:PhenotypicFeature	Inferior rectus muscle weakness	Decreased strength of the inferior rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0025601		
HP:0025602	biolink:PhenotypicFeature	Inferior rectus muscle restriction	Mechanical limitation of the range of movement of the inferior rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0025602		
HP:0001653	biolink:PhenotypicFeature	Mitral regurgitation	An abnormality of the mitral valve characterized by insufficiency or incompetence of the mitral valve resulting in retrograde leaking of blood through the mitral valve upon ventricular contraction.	SNOMEDCT_US:48724000|UMLS:C3551535|Fyler:1151|MSH:D008944|UMLS:C0026266	hp.json	Mitral regurgitation, mild|Mitral valve insufficiency|Mitral insufficiency|Mitral incompetence|Mitral valve regurgitation	http://purl.obolibrary.org/obo/HP_0001653		
HP:0001654	biolink:PhenotypicFeature	Abnormal heart valve morphology	Any structural abnormality of a cardiac valve.	MSH:D006349|UMLS:C0241654|UMLS:C0018824|SNOMEDCT_US:368009	hp.json	Valvular abnormality|Abnormality of the heart valves|Valvular heart disease	http://purl.obolibrary.org/obo/HP_0001654		
HP:0025603	biolink:PhenotypicFeature	Abnormal superior rectus muscle physiology	A functional anomaly of the superior rectus muscle, an extraocular muscle that is innervated by the superior division of the oculomotor nerve, and whose primary function is the elevation of the globe.		hp.json		http://purl.obolibrary.org/obo/HP_0025603		
GO:0090493	biolink:BiologicalProcess	catecholamine uptake	The directed movement of catecholamine into a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0090493		
GO:0090494	biolink:BiologicalProcess	dopamine uptake	The directed movement of dopamine into a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0090494		
GO:0090497	biolink:BiologicalProcess	mesenchymal cell migration	The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0090497		
CHEBI:5254	biolink:ChemicalSubstance	galactolipid			hp.json		http://purl.obolibrary.org/obo/CHEBI_5254		
HP:0001626	biolink:PhenotypicFeature	Abnormality of the cardiovascular system	Any abnormality of the cardiovascular system.	SNOMEDCT_US:49601007|MSH:D018376|MSH:D002318|UMLS:C0007222|UMLS:C0243050	hp.json	Cardiovascular disease|Cardiovascular abnormality|Abnormality of the cardiovascular system	http://purl.obolibrary.org/obo/HP_0001626		
HP:0001627	biolink:PhenotypicFeature	Abnormal heart morphology	Any structural anomaly of the heart.	UMLS:C0152021|UMLS:C0018798|MSH:D006330|SNOMEDCT_US:13213009	hp.json	Cardiac anomalies|Congenital heart defects|Congenital heart defect|Heart defect|Cardiac abnormality|Abnormality of cardiac morphology|Abnormally shaped heart|Abnormality of the heart|Cardiac anomaly	http://purl.obolibrary.org/obo/HP_0001627		
HP:0001629	biolink:PhenotypicFeature	Ventricular septal defect	A hole between the two bottom chambers (ventricles) of the heart. The defect is centered around the most superior aspect of the ventricular septum.	MSH:D006345|SNOMEDCT_US:253549006|Fyler:1300|SNOMEDCT_US:30288003|UMLS:C0018818	hp.json	Hole in heart wall separating two lower heart chambers|Ventricular septal defects|VSD|Ventriculoseptal defect	http://purl.obolibrary.org/obo/HP_0001629		
HP:0001622	biolink:PhenotypicFeature	Premature birth	The birth of a baby of less than 37 weeks of gestational age.	MSH:D047928|UMLS:C0151526|SNOMEDCT_US:367494004|SNOMEDCT_US:49550006|SNOMEDCT_US:282020008|UMLS:C0233315	hp.json	Premature delivery of affected infants|Premature delivery|Shortened gestation time|Premature birth|Preterm birth|Preterm delivery	http://purl.obolibrary.org/obo/HP_0001622		
HP:0001623	biolink:PhenotypicFeature	Breech presentation	A position of the fetus at delivery in which the fetus enters the birth canal with the buttocks or feet first.	MSH:D001946|UMLS:C0006157|SNOMEDCT_US:6096002|SNOMEDCT_US:249101006	hp.json	Feet or buttocks of fetus positioned near opening of uterus|Feet or buttocks of foetus positioned near opening of uterus|Breech presentation at birth	http://purl.obolibrary.org/obo/HP_0001623		
HP:0001620	biolink:PhenotypicFeature	High pitched voice	An abnormal increase in the pitch (frequency) of the voice.	UMLS:C0241703|SNOMEDCT_US:51406002	hp.json	High pitched voice|High-pitched voice	http://purl.obolibrary.org/obo/HP_0001620		
HP:0001621	biolink:PhenotypicFeature	Weak voice	Reduced intensity (volume) of speech.	SNOMEDCT_US:34527004|SNOMEDCT_US:8614008|MSH:D014832|UMLS:C0241700|UMLS:C0521007	hp.json	Hypophonia|Quiet voice|Soft voice|Weak voice	http://purl.obolibrary.org/obo/HP_0001621		
GO:0016485	biolink:BiologicalProcess	protein processing	Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.		hp.json	peptidolysis during protein maturation	http://purl.obolibrary.org/obo/GO_0016485		
GO:0090461	biolink:BiologicalProcess	glutamate homeostasis	Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0090461		
HP:0001637	biolink:PhenotypicFeature	Abnormal myocardium morphology	A structural anomaly of the muscle layer of the heart wall.	UMLS:C4025758	hp.json	Abnormality of the myocardium	http://purl.obolibrary.org/obo/HP_0001637		
HP:0001638	biolink:PhenotypicFeature	Cardiomyopathy	A myocardial disorder in which the heart muscle is structurally and functionally abnormal, in the absence of coronary artery disease, hypertension, valvular disease and congenital heart disease sufficient to cause the observed myocardial abnormality.	MSH:D009202|Fyler:1840|UMLS:C0878544|SNOMEDCT_US:57809008|SNOMEDCT_US:85898001	hp.json	Disease of the heart muscle	http://purl.obolibrary.org/obo/HP_0001638		
HP:0001635	biolink:PhenotypicFeature	Congestive heart failure	The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.	SNOMEDCT_US:42343007|MSH:D006333|SNOMEDCT_US:84114007|UMLS:C0018802|UMLS:C0018801	hp.json	Chronic heart failure|Heart failure|Cardiac insufficiency|Cardiac failures|Cardiac failure|CHF	http://purl.obolibrary.org/obo/HP_0001635		
HP:0001636	biolink:PhenotypicFeature	Tetralogy of Fallot	A congenital cardiac malformation comprising pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy. The diagnosis of TOF is made if at least three of the four above mentioned features are present.	SNOMEDCT_US:86299006|UMLS:C0039685|ICD-10:Q21.3|MSH:D013771	hp.json	Tetrology of fallot	http://purl.obolibrary.org/obo/HP_0001636		
HP:0001639	biolink:PhenotypicFeature	Hypertrophic cardiomyopathy	Hypertrophic cardiomyopathy (HCM) is defined by the presence of increased ventricular wall thickness or mass in the absence of loading conditions (hypertension, valve disease) sufficient to cause the observed abnormality.	SNOMEDCT_US:45227007|MSH:D002312|UMLS:C0007194|SNOMEDCT_US:233873004	hp.json	HCM|Enlarged and thickened heart muscle|Cardiomyopathy, hypertrophic	http://purl.obolibrary.org/obo/HP_0001639		
HP:0001633	biolink:PhenotypicFeature	Abnormal mitral valve morphology	Any structural anomaly of the mitral valve.	UMLS:C4025759	hp.json	Abnormality of the mitral valve	http://purl.obolibrary.org/obo/HP_0001633		
HP:0001634	biolink:PhenotypicFeature	Mitral valve prolapse	One or both of the leaflets (cusps) of the mitral valve bulges back into the left atrium upon contraction of the left ventricle.	Fyler:1533|SNOMEDCT_US:8074002|UMLS:C0026267|SNOMEDCT_US:409712001|MSH:D008945	hp.json		http://purl.obolibrary.org/obo/HP_0001634		
HP:0001631	biolink:PhenotypicFeature	Atrial septal defect	Atrial septal defect (ASD) is a congenital abnormality of the interatrial septum that enables blood flow between the left and right atria via the interatrial septum.	SNOMEDCT_US:405752007|UMLS:C0018817|SNOMEDCT_US:253366007|Fyler:2050|ICD-10:Q21.1|MSH:D006344|SNOMEDCT_US:70142008	hp.json	Atrial septum defect|ASD|Atria septal defect|Defect in the atrial septum|Hole in heart wall separating two upper heart chambers|An opening in the wall separating the top two chambers of the heart|Atrioseptal defect	http://purl.obolibrary.org/obo/HP_0001631		
GO:0016491	biolink:MolecularActivity	oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.	Reactome:R-HSA-9026917|Reactome:R-HSA-8936442|Reactome:R-HSA-1614362|Reactome:R-HSA-8878581|Reactome:R-HSA-9024624|Reactome:R-HSA-9693722|Reactome:R-HSA-9025007|Reactome:R-HSA-9026001|Reactome:R-HSA-209921|Reactome:R-HSA-390438|Reactome:R-HSA-9024630|Reactome:R-HSA-390425|EC:1.-.-.-|Reactome:R-HSA-9027033|Reactome:R-HSA-3095889|Reactome:R-HSA-9020249|Reactome:R-HSA-9020260|Reactome:R-HSA-209960|Reactome:R-HSA-5662660	hp.json	oxidoreductase activity, acting on other substrates|redox activity	http://purl.obolibrary.org/obo/GO_0016491		goslim_candida|goslim_yeast|goslim_generic|prokaryote_subset|goslim_pir|goslim_drosophila|goslim_metagenomics|goslim_chembl|goslim_mouse
CHEBI:7896	biolink:ChemicalSubstance	hexadecanoate	A long-chain fatty acid anion that is the conjugate base of hexadecanoic acid (palmitic acid); major species at pH 7.3.	HMDB:HMDB0000220|Gmelin:344266|CAS:143-20-4|MetaCyc:PALMITATE|Reaxys:3589907|Beilstein:3589907	hp.json	hexadecanoate|Hexadecanoic acid, ion(1-)|n-hexadecoate|CH3-[CH2]14-COO(-)|hexadecanoate|n-hexadecanoate|pentadecanecarboxylate|1-pentadecanecarboxylate|(16:0)|palmitate|1-hexyldecanoate	http://purl.obolibrary.org/obo/CHEBI_7896		3_STAR
UBERON:0018265	biolink:AnatomicalEntity	anterior root of zygomatic arch	The anterior or rostral end of the zygomatic arch, which includes the temporal process of the zygomatic bone, but also including some of the body of the zygomatic bone. It may also include the zygomatico-temporal suture and the most rostral portion of the zygomatic process of the temporal bone.	MFMO:0000109	hp.json		http://purl.obolibrary.org/obo/UBERON_0018265		
UBERON:0018261	biolink:AnatomicalEntity	muscular coat of digestive tract	A muscular coat that is part of a digestive tract.		hp.json	muscular layer of digestive tract|muscularis externa of digestive tract|tunica muscularis of digestive tract|tunica externa of digestive tract	http://purl.obolibrary.org/obo/UBERON_0018261		
UBERON:0006289	biolink:AnatomicalEntity	rib pre-cartilage condensation	A rib endochondral element that is composed primarily of a pre-cartilage condensation.	VHOG:0000681|EMAPA:17397|EHDAA:6026|EHDAA2:0001717	hp.json		http://purl.obolibrary.org/obo/UBERON_0006289		emapa_ehdaa2
UBERON:0006288	biolink:AnatomicalEntity	rib cartilage element	A rib endochondral element that is composed primarily of cartilage tissue.	EHDAA:8347|EHDAA2:0001716|EMAPA:17678|VHOG:0001122	hp.json		http://purl.obolibrary.org/obo/UBERON_0006288		emapa_ehdaa2
UBERON:0006287	biolink:AnatomicalEntity	radius-ulna pre-cartilage condensation	A radius-ulna endochondral element that is composed primarily of a pre-cartilage condensation.	VHOG:0000949|EMAPA:17420|EHDAA2:0001587|EHDAA:4178	hp.json		http://purl.obolibrary.org/obo/UBERON_0006287		
UBERON:0006286	biolink:AnatomicalEntity	radius cartilage element	A cartilaginous condensation that has the potential to develop into a radius bone.	VHOG:0001318|EHDAA2:0001585|EMAPA:18054|EHDAA:7267	hp.json		http://purl.obolibrary.org/obo/UBERON_0006286		
UBERON:0006285	biolink:AnatomicalEntity	pubic pre-cartilage condensation	A pubic endochondral element that is composed primarily of a pre-cartilage condensation.	VHOG:0000965|EHDAA2:0001574|EMAPA:18349|EHDAA:9572	hp.json		http://purl.obolibrary.org/obo/UBERON_0006285		emapa_ehdaa2
UBERON:0006284	biolink:AnatomicalEntity	early prosencephalic vesicle	Future brain vesicle that gives rise to telencephalic ventricle/lateral ventricles and 3rd ventricle.	TAO:0001259|EHDAA:1356|DHBA:10595|VHOG:0000644|EHDAA2:0001571|ZFA:0001259|EMAPA:16521	hp.json	forebrain vesicle|preevaginated forebrain vesicle|prosencephalic ventricle|prosencephalic vesicle|forebrain ventricle	http://purl.obolibrary.org/obo/UBERON_0006284		
UBERON:0006283	biolink:AnatomicalEntity	future cardiac ventricle	Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle.	FMA:71006|EMAPA:16350|ZFA:0001719|EHDAA2:0001531|Wikipedia:Embryonic_ventricle|TAO:0002231|NCIT:C34160|SCTID:361524003	hp.json	primordial cardiac ventricle|early heart ventricle|future heart ventricle|embryonic heart ventricle|presumptive cardiac ventricle heart tube|primitive ventricle|primordial ventricle|primitive ventricle of heart|embryonic ventricle	http://purl.obolibrary.org/obo/UBERON_0006283		
UBERON:0018260	biolink:AnatomicalEntity	layer of muscle tissue	Any organ component layer that consists of muscle tissue.	UMLS:C0225358|FMA:45634|NCIT:C75444	hp.json		http://purl.obolibrary.org/obo/UBERON_0018260		
UBERON:0018256	biolink:AnatomicalEntity	lacrimal vein	A vein that drains a lacrimal gland.	FMA:51779	hp.json		http://purl.obolibrary.org/obo/UBERON_0018256		human_reference_atlas
UBERON:0018257	biolink:AnatomicalEntity	submucosa of digestive tract	Any portion of submucosa that lines the digestive tract.		hp.json		http://purl.obolibrary.org/obo/UBERON_0018257		
UBERON:0018254	biolink:AnatomicalEntity	skeletal musculature		EHDAA2:0001842|MA:0000165|EMAPA:35578	hp.json		http://purl.obolibrary.org/obo/UBERON_0018254		grouping_class
UBERON:0018255	biolink:AnatomicalEntity	jejunal artery	A branch of the superior mesenteric artery that supplies the jejunum.	FMA:14808	hp.json	jejunal branch of superior mesenteric artery	http://purl.obolibrary.org/obo/UBERON_0018255		
UBERON:0018252	biolink:AnatomicalEntity	internal pudendal vein	Accompanying vein of internal pudendal artery.	FMA:18917	hp.json	internal pudic vein|vena pudenda interna	http://purl.obolibrary.org/obo/UBERON_0018252		human_reference_atlas
UBERON:0018251	biolink:AnatomicalEntity	meningeal vein	One of the veins draining a meninix.	SCTID:84842006|FMA:50839	hp.json		http://purl.obolibrary.org/obo/UBERON_0018251		
UBERON:0006274	biolink:AnatomicalEntity	tetrapod parietal bone primordium		EHDAA2:0001404|FMA:312593|EHDAA:9544|EMAPA:18019	hp.json	parietal bone primordium	http://purl.obolibrary.org/obo/UBERON_0006274		emapa_ehdaa2
UBERON:0006273	biolink:AnatomicalEntity	otic pit	The pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles.	NCIT:C34238|EHDAA2:0001336|EHDAA:929|FMA:302911|EMAPA:16536|VHOG:0001147	hp.json	otic cup	http://purl.obolibrary.org/obo/UBERON_0006273		emapa_ehdaa2|pheno_slim
UBERON:0006271	biolink:AnatomicalEntity	orbital fissure	Either of two openings transmitting nerves and blood vessels to or from the orbit.	EMAPA:18717|EHDAA:10648|EHDAA2:0001328	hp.json		http://purl.obolibrary.org/obo/UBERON_0006271		emapa_ehdaa2
UBERON:0006279	biolink:AnatomicalEntity	pleuroperitoneal canal	Each of the canals that links the peritoneal cavity and the caudal part of a pleural cavity.	SCTID:361413002|EHDAA:4128|VHOG:0001505|EMAPA:17707|EMAPA:17704|EHDAA2:0001481	hp.json	pleuroperitoneal channel	http://purl.obolibrary.org/obo/UBERON_0006279		emapa_ehdaa2
UBERON:0018246	biolink:AnatomicalEntity	thyroid vein	A vein that drains a thyroid gland.	EMAPA:18648	hp.json		http://purl.obolibrary.org/obo/UBERON_0018246		
UBERON:0018243	biolink:AnatomicalEntity	thymic artery	A vein that supplies blood to the thymus.	FMA:10647	hp.json	thymic arteries|thymic branch of internal thoracic artery	http://purl.obolibrary.org/obo/UBERON_0018243		human_reference_atlas
GO:2000401	biolink:BiologicalProcess	regulation of lymphocyte migration	Any process that modulates the frequency, rate or extent of lymphocyte migration.		hp.json		http://purl.obolibrary.org/obo/GO_2000401		
GO:2000402	biolink:BiologicalProcess	negative regulation of lymphocyte migration	Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration.		hp.json		http://purl.obolibrary.org/obo/GO_2000402		
GO:2000403	biolink:BiologicalProcess	positive regulation of lymphocyte migration	Any process that activates or increases the frequency, rate or extent of lymphocyte migration.		hp.json		http://purl.obolibrary.org/obo/GO_2000403		
GO:2000404	biolink:BiologicalProcess	regulation of T cell migration	Any process that modulates the frequency, rate or extent of T cell migration.		hp.json	regulation of T lymphocyte migration|regulation of T-lymphocyte migration|regulation of T-cell migration	http://purl.obolibrary.org/obo/GO_2000404		
GO:2000405	biolink:BiologicalProcess	negative regulation of T cell migration	Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration.		hp.json	negative regulation of T-cell migration|negative regulation of T lymphocyte migration|negative regulation of T-lymphocyte migration	http://purl.obolibrary.org/obo/GO_2000405		
GO:2000406	biolink:BiologicalProcess	positive regulation of T cell migration	Any process that activates or increases the frequency, rate or extent of T cell migration.		hp.json	positive regulation of T-cell migration|positive regulation of T lymphocyte migration|positive regulation of T-lymphocyte migration	http://purl.obolibrary.org/obo/GO_2000406		
UBERON:0018247	biolink:AnatomicalEntity	cervical thymic artery	An artery that supplies a cervical thymus.		hp.json		http://purl.obolibrary.org/obo/UBERON_0018247		
UBERON:0006267	biolink:AnatomicalEntity	notochordal plate	The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.	VHOG:0001212|EMAPA:16101|UMLS:C1518429|EHDAA2:0001278|EHDAA:264|NCIT:C34231	hp.json		http://purl.obolibrary.org/obo/UBERON_0006267		emapa_ehdaa2
UBERON:0006266	biolink:AnatomicalEntity	nasolacrimal groove	Groove between maxillary prominence and lateral nasal process.	NCIT:C34218|FMA:300055|EHDAA2:0001238|VHOG:0001307|EHDAA:4770|UMLS:C1513875|EMAPA:16679	hp.json	s. lacrimalis maxillae|naso-lacrimal groove	http://purl.obolibrary.org/obo/UBERON_0006266		emapa_ehdaa2
UBERON:0006264	biolink:AnatomicalEntity	mouth-foregut junction	An anatomical junctions that overlaps the mouth and foregut.	EMAPA:16258|VHOG:0000592|EHDAA:534|RETIRED_EHDAA2:0001205	hp.json		http://purl.obolibrary.org/obo/UBERON_0006264		emapa_ehdaa2
UBERON:0006263	biolink:AnatomicalEntity	Meckel's cartilage pre-cartilage condensation		EMAPA:17358|VHOG:0001121|EHDAA2:0001074	hp.json		http://purl.obolibrary.org/obo/UBERON_0006263		emapa_ehdaa2
UBERON:0006262	biolink:AnatomicalEntity	malleus pre-cartilage condensation	A malleus endochondral element that is composed primarily of a pre-cartilage condensation.	VHOG:0000958|EHDAA2:0001055|EMAPA:17826|EHDAA:9026	hp.json		http://purl.obolibrary.org/obo/UBERON_0006262		emapa_ehdaa2
UBERON:0006261	biolink:AnatomicalEntity	male genital tubercle	A differentiated genital tubercle that is part of a male reproductive system.	EHDAA:8138|VHOG:0000667|EMAPA:17969|RETIRED_EHDAA2:0001048	hp.json	genital tubercle of male|penis anlage	http://purl.obolibrary.org/obo/UBERON_0006261		emapa_ehdaa2
UBERON:0006260	biolink:AnatomicalEntity	lingual swellings		EHDAA2:0000996|EMAPA:17186|VHOG:0000449	hp.json	lingual swelling	http://purl.obolibrary.org/obo/UBERON_0006260		emapa_ehdaa2
CHEBI:16235	biolink:ChemicalSubstance	guanine	A 2-aminopurine carrying a 6-oxo substituent.	CAS:73-40-5|MetaCyc:GUANINE|Wikipedia:Guanine|CAS:73-40-5|PMID:22770225|Gmelin:431879|CAS:73-40-5|KEGG:C00242|PDBeChem:GUN|Beilstein:147911|Reaxys:147911|PMID:8070089|KNApSAcK:C00001501|HMDB:HMDB0000132|DrugBank:DB02377	hp.json	GUANINE|Gua|guanine|2-Amino-6-hydroxypurine|2-amino-6-oxopurine|G|2-amino-1,9-dihydro-6H-purin-6-one|Guanine	http://purl.obolibrary.org/obo/CHEBI_16235		3_STAR
UBERON:0006268	biolink:AnatomicalEntity	notochordal process	A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.	EMAPA:16102|EHDAA:224|EHDAA2:0001279|FMA:293135|UMLS:C1518430|NCIT:C34232|VHOG:0001213	hp.json	chordamesoderm|presumptive notochord	http://purl.obolibrary.org/obo/UBERON_0006268		emapa_ehdaa2
UBERON:0018234	biolink:AnatomicalEntity	stroma of pancreas	A stroma that is part of a pancreas.	FMA:63121	hp.json	pancreatic stroma	http://purl.obolibrary.org/obo/UBERON_0018234		human_reference_atlas
UBERON:0018235	biolink:AnatomicalEntity	capsule of pancreas	A capsule that divides the parenchyma of the pancreas into lobes and lobules.		hp.json	pancreatic capsule	http://purl.obolibrary.org/obo/UBERON_0018235		
UBERON:0018232	biolink:AnatomicalEntity	axillary sweat gland	A sweat gland that is part of a axilla.		hp.json	sweat gland of axilla|axillary apocrine sweat gland	http://purl.obolibrary.org/obo/UBERON_0018232		
UBERON:0018239	biolink:AnatomicalEntity	rhombomere boundary	A boundary delimiting a rhombomere.		hp.json	rhombomere junction	http://purl.obolibrary.org/obo/UBERON_0018239		
UBERON:0006256	biolink:AnatomicalEntity	knee joint primordium		EHDAA2:0000897|EMAPA:17740|EHDAA:8467	hp.json		http://purl.obolibrary.org/obo/UBERON_0006256		emapa_ehdaa2
UBERON:0006255	biolink:AnatomicalEntity	ischial pre-cartilage condensation	An ischial endochondral element that is composed primarily of a pre-cartilage condensation.	EHDAA:7153|EMAPA:18348|EHDAA2:0000891|VHOG:0000962	hp.json		http://purl.obolibrary.org/obo/UBERON_0006255		emapa_ehdaa2
UBERON:0006254	biolink:AnatomicalEntity	ischial cartilage element	An ischial endochondral element that is composed primarily of cartilage tissue.	EMAPA:26930|EHDAA:9570|EHDAA2:0000890	hp.json	ischial cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0006254		emapa_ehdaa2
UBERON:0018299	biolink:AnatomicalEntity	mandibular symphyseal tooth	Tooth of the lower jaw that is adjacent to the mandibular symphysis.	UBERONTEMP:2f99ad4b-d842-4ae9-8886-87ee98811fe5	hp.json	symphyseal tooth|lower jaw symphyseal tooth	http://purl.obolibrary.org/obo/UBERON_0018299		
OBI:0002650	biolink:NamedThing	biopsy	A specimen collection that obtains a sample of tissue or cell from a living multicellular organism body for diagnostic purposes by means intended to be minimally invasive.		hp.json		http://purl.obolibrary.org/obo/OBI_0002650		
OBI:0002651	biolink:NamedThing	image guided biopsy	A biopsy which uses an imaging procedure to guide a needle biopsy.		hp.json		http://purl.obolibrary.org/obo/OBI_0002651		
OBI:0002654	biolink:NamedThing	needle biopsy	A biopsy that uses a hollow needle to extract cells.		hp.json		http://purl.obolibrary.org/obo/OBI_0002654		
OBI:0002655	biolink:NamedThing	fine needle aspiration biopsy	A biopsy that uses a thin needle to extract cells.		hp.json		http://purl.obolibrary.org/obo/OBI_0002655		
OBI:0002652	biolink:NamedThing	computed tomography assisted biopsy	A needle biopsy guided by real-time computed tomography (CT) scan images.		hp.json		http://purl.obolibrary.org/obo/OBI_0002652		
OBI:0002653	biolink:NamedThing	ultrasound-guided needle biopsy	A needle biopsy guided by ultrasound visualization.		hp.json		http://purl.obolibrary.org/obo/OBI_0002653		
OBI:0002656	biolink:NamedThing	core needle biopsy	A biopsy that uses a hollow tube to collect a core of tissue.		hp.json		http://purl.obolibrary.org/obo/OBI_0002656		
OBI:0002657	biolink:NamedThing	surgical biopsy	A biopsy involving a surgical incision into an organism to access the biopsy material.		hp.json		http://purl.obolibrary.org/obo/OBI_0002657		
PR:P01350	biolink:Protein	gastrin (human)	A gastrin that is encoded in the genome of human.	UniProtKB:P01350	hp.json	hGAST|GAST|GAS	http://purl.obolibrary.org/obo/PR_P01350		
OBO:uberon/core#conduit_for	biolink:NamedThing	conduit for	x is a conduit for y iff y passes through the lumen of x.		hp.json		http://purl.obolibrary.org/obo/uberon/core#conduit_for		
UBERON:0006292	biolink:AnatomicalEntity	shoulder joint primordium		EMAPA:17712|EHDAA2:0001836|EHDAA:8493	hp.json		http://purl.obolibrary.org/obo/UBERON_0006292		emapa_ehdaa2
UBERON:0006291	biolink:AnatomicalEntity	scapula pre-cartilage condensation	A scapula endochondral element that is composed primarily of a pre-cartilage condensation.	VHOG:0000960|EHDAA:6041|EMAPA:18027|EHDAA2:0001778	hp.json		http://purl.obolibrary.org/obo/UBERON_0006291		emapa_ehdaa2
UBERON:0006290	biolink:AnatomicalEntity	scapula cartilage element	A scapula endochondral element that is composed primarily of cartilage tissue.	EHDAA:8368|VHOG:0001125|EHDAA2:0001777|EMAPA:18343	hp.json		http://purl.obolibrary.org/obo/UBERON_0006290		emapa_ehdaa2
UBERON:0006298	biolink:AnatomicalEntity	submandibular gland primordium	A primordium that has the potential to develop into a submandibular gland.	EHDAA2:0001939|EHDAA:9255|EMAPA:17755	hp.json	submaxillary gland primordium	http://purl.obolibrary.org/obo/UBERON_0006298		emapa_ehdaa2
UBERON:0006297	biolink:AnatomicalEntity	sublingual gland primordium	A primordium that has the potential to develop into a sublingual gland.	EHDAA:7989|EHDAA2:0001935|EMAPA:17752	hp.json		http://purl.obolibrary.org/obo/UBERON_0006297		emapa_ehdaa2
UBERON:0006295	biolink:AnatomicalEntity	sternebral bone pre-cartilage condensation		VHOG:0000961|EHDAA:9565|EHDAA2:0001912|EMAPA:18345	hp.json		http://purl.obolibrary.org/obo/UBERON_0006295		emapa_ehdaa2
UBERON:0006294	biolink:AnatomicalEntity	stapes pre-cartilage condensation	A stapes endochondral element that is composed primarily of a pre-cartilage condensation.	EHDAA:5699|VHOG:0000956|EMAPA:17827|EHDAA2:0001910	hp.json	stapedial anlage	http://purl.obolibrary.org/obo/UBERON_0006294		emapa_ehdaa2
UBERON:0006293	biolink:AnatomicalEntity	spleen primordium	A dense syncitial-like mesenchymal thickening in the dorsal mesogastrium[ISBN]. the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen[MP].	EHDAA:3003|XAO:0000326|EHDAA2:0001904|EMAPA:18535	hp.json	spleen mesenchyme|splenic primordium|left spleen primordium|splenic mesenchyme	http://purl.obolibrary.org/obo/UBERON_0006293		pheno_slim
CHEBI:16180	biolink:ChemicalSubstance	N-acylglycine	An N-acyl-amino acid in which amino acid specified is glycine.	MetaCyc:CPD-426|KEGG:C02055	hp.json	N-Acylglycine	http://purl.obolibrary.org/obo/CHEBI_16180		3_STAR
UBERON:0018302	biolink:AnatomicalEntity	upper molar 1	First molar (counting anteroposteriorly) in the upper jaw.	UBERONTEMP:12acbe6c-9036-48e3-b1a0-1f2fdaa0241d	hp.json		http://purl.obolibrary.org/obo/UBERON_0018302		
UBERON:0018303	biolink:AnatomicalEntity	adrenal tissue	Tissue that is part of some adrenal gland.	UBERONTEMP:a7bf197b-0db2-467e-824e-be45b39e2672|NCIT:C32051	hp.json	adrenal gland tissue	http://purl.obolibrary.org/obo/UBERON_0018303		
UBERON:0006322	biolink:AnatomicalEntity	inferior rectus extraocular muscle	A muscle in the orbit that depresses, adducts, and helps extort (rotate laterally) the eye. The inferior rectus muscle is the only muscle that is capable of depressing the pupil when it is in a fully abducted position.	UMLS:C0582819|AAO:0010101|NCIT:C32790|ZFA:0000457|TAO:0000457|FMA:49036|MA:0001279|VHOG:0001130	hp.json	m. rectus inferior|inferior rectus muscle|ventral rectus|inferior rectus|ventral recti|musculus rectus inferior|ventral rectus extraocular muscle|musculus rectus inferior bulbi	http://purl.obolibrary.org/obo/UBERON_0006322		vertebrate_core
UBERON:0006321	biolink:AnatomicalEntity	superior oblique extraocular muscle	The superior oblique muscle, or obliquus oculi superior, is a fusiform muscle in the upper, medial side of the orbit whose primary action is downward, lateral rotation of the eye. One of the extraocular muscles, the superior oblique is the only muscle innervated by the trochlear nerve (the fourth cranial nerve).	MA:0001277|ZFA:0000738|TAO:0000738|FMA:49039|AAO:0010119|VHOG:0001131|UMLS:C0582816|NCIT:C33688	hp.json	obliquus oculi superior|M. obliquus superior|musculus obliquus superior bulbi|dorsal oblique extraocular muscles|superior oblique|dorsal oblique extraocular muscle|obliquus superior|superior oblique muscle|musculus obliquus superior	http://purl.obolibrary.org/obo/UBERON_0006321		vertebrate_core
UBERON:0006320	biolink:AnatomicalEntity	inferior oblique extraocular muscle	Thin, narrow muscle placed near the anterior margin of the floor of the orbit.	TAO:0000861|UMLS:C0582817|MA:0001276|NCIT:C32783|FMA:49040|VHOG:0001132|ZFA:0000861|AAO:0010117	hp.json	m. obliquus inferior|musculus obliquus inferior bulbi|musculus obliquus inferior bulbi|inferior oblique|obliquus inferior|ventral oblique extraocular muscles|inferior oblique muscle|obliquus oculi inferior|ventral oblique extraocular muscle|musculus obliquus inferior	http://purl.obolibrary.org/obo/UBERON_0006320		vertebrate_core
UBERON:0008987	biolink:AnatomicalEntity	renal parenchyma	The functional tissue of the kidney, consisting of the nephrons.	BTO:0003604|FMA:15574	hp.json	parenchyma of kidney|kidney parenchyma	http://purl.obolibrary.org/obo/UBERON_0008987		
UBERON:0008989	biolink:AnatomicalEntity	submucosal esophageal gland	One of the racemose glands in the walls of the esophagus that in humans are small and serve principally to lubricate the food but in some birds secrete a milky fluid on which the young are fed.	Wikipedia:Esophageal_glands|UMLS:C0227178|BTO:0003634|NCIT:C32536|SCTID:322749003|FMA:9404	hp.json	submocosal esophageal gland|glandulae oesophageae|glandulae oesophageae|esophageal gland|mucous gland of submucosa of esophagus	http://purl.obolibrary.org/obo/UBERON_0008989		
UBERON:0006328	biolink:AnatomicalEntity	laryngeal intrinsic muscle		MA:0001770|EMAPA:37630|FMA:55226	hp.json	intrinsic laryneal muscles|intrinsic laryngeal muscle|intrinsic muscle of larynx	http://purl.obolibrary.org/obo/UBERON_0006328		
UBERON:0008982	biolink:AnatomicalEntity	fascia	A dense regular connective tissue that that connects muscles together[WP, modified].	MESH:D005205|BTO:0002930|EV:0100150|UMLS:C0015641|NCIT:C13108|FMA:30318	hp.json	fascia cluster	http://purl.obolibrary.org/obo/UBERON_0008982		pheno_slim
UBERON:0006325	biolink:AnatomicalEntity	laryngeal intrinsic ligament		FMA:72058|MA:0001757|EMAPA:37628	hp.json	intrinsic ligament of larynx	http://purl.obolibrary.org/obo/UBERON_0006325		
UBERON:0008974	biolink:AnatomicalEntity	apocrine gland	Any exocrine gland whose cells bud their secretions off through the plasma membrane producing membrane-bound vesicles in the lumen; the apical portion of the secretory cell of the gland pinches off and enters the lumen; it loses part of its cytoplasm in their secretions; apocrine secretion is functional during hormonal stress or puberty; an example of true apocrine glands are mammary glands, responsible for secreting breast milk.	EMAPA:35141|MA:0003040|MESH:D001050|BTO:0001162	hp.json	true apocrine gland	http://purl.obolibrary.org/obo/UBERON_0008974		organ_slim|pheno_slim|human_reference_atlas
UBERON:0006311	biolink:AnatomicalEntity	chamber of eyeball	A segment of the eyeball that is filled with refractive media.	NCIT:C32301|FMA:58071|UMLS:C0459556|SCTID:280540004|MA:0002459|BTO:0002085|EMAPA:37529	hp.json	chamber of eye|eyeball chamber|eye chamber	http://purl.obolibrary.org/obo/UBERON_0006311		
GO:2000471	biolink:BiologicalProcess	regulation of hematopoietic stem cell migration	Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration.		hp.json	regulation of hemopoietic stem cell migration	http://purl.obolibrary.org/obo/GO_2000471		
GO:2000472	biolink:BiologicalProcess	negative regulation of hematopoietic stem cell migration	Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration.		hp.json	negative regulation of hemopoietic stem cell migration	http://purl.obolibrary.org/obo/GO_2000472		
GO:2000473	biolink:BiologicalProcess	positive regulation of hematopoietic stem cell migration	Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration.		hp.json	positive regulation of hemopoietic stem cell migration	http://purl.obolibrary.org/obo/GO_2000473		
CHEBI:43799	biolink:ChemicalSubstance	butan-1-amine	A primary aliphatic amine that is butane substituted by an amino group at position 1.	CAS:109-73-9|PMID:23470444|Wikipedia:N-Butylamine|MetaCyc:BUTYLAMINE|PDBeChem:LYT|PMID:23734590|CAS:109-73-9|Beilstein:605269|Reaxys:605269|DrugBank:DB03659|Gmelin:1784|PMID:16387436	hp.json	mono-n-butylamine|butanamine|1-aminobutane|monobutylamine|n-Butylamin|butan-1-amine|1-butanamine|butylamine|1-butylamine|n-butylamine|BUTYLAMINE|1-Aminobutan|n-C4H9NH2	http://purl.obolibrary.org/obo/CHEBI_43799		3_STAR
OIO:hasRelatedSynonym	biolink:NamedThing	has_related_synonym			hp.json		http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym		
UBERON:0006314	biolink:AnatomicalEntity	bodily fluid	Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not.	GAID:266|BIRNLEX:20|FMA:280556|galen:BodyFluid|EMAPA:37441|MESH:D001826|Wikipedia:Body_fluid	hp.json	fluid|body fluid	http://purl.obolibrary.org/obo/UBERON_0006314		pheno_slim
UBERON:0006312	biolink:AnatomicalEntity	ocular refractive media	Body substance in a liquid or semi-solid state in the eyeball which serves to refract light.	MA:0001911	hp.json		http://purl.obolibrary.org/obo/UBERON_0006312		
CHEBI:77119	biolink:ChemicalSubstance	EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor	An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of prostaglandin-E2 9-reductase (EC 1.1.1.189).	Wikipedia:Prostaglandin-E2_9-reductase	hp.json	PGE2-9-ketoreductase inhibitors|(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitor|prostaglandin E 9-ketoreductase inhibitors|prostaglandin E2-9-oxoreductase inhibitor|PGE2-9-OR inhibitor|PGE2-9-OR inhibitors|prostaglandin E2-9-oxoreductase inhibitors|prostaglandin E 9-ketoreductase inhibitor|(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitors|PGE2-9-ketoreductase inhibitor|9-keto-prostaglandin E2 reductase inhibitor|reductase, 15-hydroxy-9-oxoprostaglandin inhibitors|EC 1.1.1.189 inhibitor|PGE-9-ketoreductase inhibitors|9-ketoprostaglandin reductase inhibitor|prostaglandin 9-ketoreductase inhibitor|PGE2 9-oxoreductase inhibitor|prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitor|prostaglandin-E2 9-reductase (EC 1.1.1.189) inhibitors|EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitors|PGE2 9-oxoreductase inhibitors|prostaglandin 9-ketoreductase inhibitors|9-ketoprostaglandin reductase inhibitors|PGE-9-ketoreductase inhibitor|EC 1.1.1.189 inhibitors|reductase, 15-hydroxy-9-oxoprostaglandin inhibitor|9-keto-prostaglandin E2 reductase inhibitors	http://purl.obolibrary.org/obo/CHEBI_77119		3_STAR
HP:0025596	biolink:PhenotypicFeature	Abnormal inferior oblique muscle physiology	A functional anomaly of the inferior oblique muscle, an extraocular muscle that has its origin on the maxillary bone just posterior to the inferior medial orbital rim and lateral to the nasolacrimal canal and that is innervated by the inferior branch of the oculomotor nerve.		hp.json		http://purl.obolibrary.org/obo/HP_0025596		
HP:0025597	biolink:PhenotypicFeature	Inferior oblique muscle restriction	Mechanical limitation of the range of movement of the inferior oblique muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0025597		
HP:0025598	biolink:PhenotypicFeature	Inferior oblique muscle weakness	Decreased strength of the inferior oblique muscle.		hp.json	Inferior oblique palsy	http://purl.obolibrary.org/obo/HP_0025598		
HP:0025599	biolink:PhenotypicFeature	Inferior oblique muscle overaction	A common ocular motility disorder characterized by vertical incomitance of the eyes in lateral gaze. In primary inferior oblique muscle overaction, an upshoot of the adducting eye occurs when gaze is directed into the field of action of the inferior oblique muscle, producing a greater upward excursion of the adducted eye than of the abducted eye.		hp.json		http://purl.obolibrary.org/obo/HP_0025599		
UBERON:0008969	biolink:AnatomicalEntity	dental follicle	A sac containing the developing tooth and its odontogenic organ. The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts, cementoblasts and fibroblasts. They develop into the alveolar bone, the cementum with Sharpey's fibers and the periodontal ligament fibers respectively.	EMAPA:35275|NCIT:C34138|BTO:0000337|MA:0003121	hp.json	dental sac|tooth follicle	http://purl.obolibrary.org/obo/UBERON_0008969		
CHEBI:16199	biolink:ChemicalSubstance	urea	A carbonyl group with two C-bound amine groups. The commercially available fertilizer has an analysis of 46-0-0 (N-P2O5-K2O).	Beilstein:635724|UM-BBD_compID:c0165|CAS:57-13-6|HMDB:HMDB0000294|Reaxys:635724|PMID:18037357|PDBeChem:URE|CAS:57-13-6|KNApSAcK:C00007314|CAS:57-13-6|PMID:22770225|DrugBank:DB03904|KEGG:D00023|Wikipedia:Urea|KEGG:C00086|Drug_Central:4264|MetaCyc:UREA|YMDB:YMDB00003|Gmelin:1378|PPDB:1728|ECMDB:ECMDB04172	hp.json	carbonyldiamide|UREA|Harnstoff|carbamide|urea|ur|uree|Karbamid|urea|E927b|Carbamide|Urea|H2NC(O)NH2|1728	http://purl.obolibrary.org/obo/CHEBI_16199		3_STAR
HP:0025590	biolink:PhenotypicFeature	Abnormal extraocular muscle physiology	A functional anomaly of the muscles of the eye.		hp.json		http://purl.obolibrary.org/obo/HP_0025590		
UBERON:0006306	biolink:AnatomicalEntity	ulna cartilage element	A cartilaginous condensation that has the potential to develop into a ulna.	VHOG:0001155|EMAPA:18055|EHDAA:7269|EHDAA2:0002098	hp.json		http://purl.obolibrary.org/obo/UBERON_0006306		
HP:0025591	biolink:PhenotypicFeature	Abnormal superior oblique muscle physiology	A functional anomaly of the superior oblique muscle, a fusiform muscle that originates in the upper, medial side of the orbit. The superior oblique muscle abducts, depresses and internally rotates the eye, and is the only extraocular muscle innervated by the fourth cranial nerve.		hp.json		http://purl.obolibrary.org/obo/HP_0025591		
HP:0025592	biolink:PhenotypicFeature	Superior oblique muscle weakness	Decreased strength of the superior oblique muscle.		hp.json	Superior oblique palsy	http://purl.obolibrary.org/obo/HP_0025592		
UBERON:0006304	biolink:AnatomicalEntity	future trigeminal ganglion		EMAPA:16663|RETIRED_EHDAA2:0002089|EHDAA:924	hp.json	trigeminal V preganglion|trigeminal preganglion	http://purl.obolibrary.org/obo/UBERON_0006304		emapa_ehdaa2
HP:0025593	biolink:PhenotypicFeature	Superior oblique muscle restriction	Mechanical limitation of the range of movement of the superior oblique muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0025593		
HP:0025594	biolink:PhenotypicFeature	Superior oblique muscle overaction	An ocular motility abnormality characterized by an overacting superior oblique muscle resulting to vertical incomitance of the eyes in lateral gaze. On examination, this is commonly seen as a downshoot of the adducting eye occuring when gaze is directed into the field of action of the inferior oblique muscle, producing a greater downward excursion of the adducted eye than of the abducted eye.		hp.json		http://purl.obolibrary.org/obo/HP_0025594		
UBERON:0008962	biolink:AnatomicalEntity	forelimb bone	A bone that is part of a forelimb region. Examples: humerus, any of the phalanges. Counter-example: scapula (a bone of the pectoral girdle). Note that we consider the forelimb to end at the shoulder.	UMLS:C0003793|GAID:178|NCIT:C12983|MESH:D001133	hp.json	free forelimb bone|wing bone|wing bone	http://purl.obolibrary.org/obo/UBERON_0008962		
HP:0025595	biolink:PhenotypicFeature	Superior oblique muscle underaction	Reduced ocular movement of the superior oblique muscle which improves on testing ductions, typically associated with neurogenic palsy.		hp.json	Under-depression in adduction	http://purl.obolibrary.org/obo/HP_0025595		
CHEBI:28159	biolink:ChemicalSubstance	D-asparagine	An optically active form of asparagine having D-configuration.	KEGG:C01905|DrugBank:DB03943|Reaxys:1723526|Beilstein:1723526|Gmelin:101784|HMDB:HMDB0033780|PMID:767332|YMDB:YMDB00849|PDBeChem:DSG|Patent:CN101333175|CAS:2058-58-4|CAS:2058-58-4|MetaCyc:CPD-3633	hp.json	D-2-aminosuccinamic acid|D-asparagine|D-Asparagin|D-Asparagine|(2R)-2-amino-3-carbamoylpropanoic acid|D-aspartic acid beta-amide|DSG|(R)-2-amino-3-carbamoylpropanoic acid|(2R)-2,4-diamino-4-oxobutanoic acid	http://purl.obolibrary.org/obo/CHEBI_28159		3_STAR
HP:0025585	biolink:PhenotypicFeature	Hyperphoria	Tendency for the visual axis of one eye to be higher than that of the other.		hp.json		http://purl.obolibrary.org/obo/HP_0025585		
HP:0025586	biolink:PhenotypicFeature	Hypertropia	A type of strabismus characterized by permanent upward deviation of the visual axis of one eye.		hp.json		http://purl.obolibrary.org/obo/HP_0025586		
HP:0025587	biolink:PhenotypicFeature	Hyperdeviation	A type of strabismus in which the visual axis of one eye is higher than that of the other.		hp.json		http://purl.obolibrary.org/obo/HP_0025587		
GO:2000495	biolink:BiologicalProcess	regulation of cell proliferation involved in compound eye morphogenesis	Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_2000495		
HP:0025588	biolink:PhenotypicFeature	Hypodeviation	A type of strabismus in which the visual axis of one eye is lower than that of the other.		hp.json		http://purl.obolibrary.org/obo/HP_0025588		
GO:2000496	biolink:BiologicalProcess	negative regulation of cell proliferation involved in compound eye morphogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_2000496		
HP:0025589	biolink:PhenotypicFeature	Cyclodeviation	Cyclodeviation is defined as the rotation of an eyeball along the anteroposterior axis and cyclotropia as a misalignment of cyclodeviation between the two eyes.		hp.json		http://purl.obolibrary.org/obo/HP_0025589		
GO:2000497	biolink:BiologicalProcess	positive regulation of cell proliferation involved in compound eye morphogenesis	Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_2000497		
CHEBI:16189	biolink:ChemicalSubstance	sulfate	A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid.	PMID:16742508|PMID:17420092|PMID:16656509|PMID:16742518|Reaxys:3648446|Beilstein:3648446|PMID:15093386|CAS:14808-79-8|MetaCyc:SULFATE|PMID:14597181|PMID:16534979|Gmelin:2120|Wikipedia:Sulfate|PMID:12668033|PMID:11200094|PMID:19047345|PMID:17120760|PMID:16345535|PDBeChem:SO4|PMID:12166931|KEGG:C00059|PMID:30398859|PMID:18398178|CAS:14808-79-8|PMID:19244483|PMID:16348007|PMID:19812358|PMID:16186560|PMID:18846414|KEGG:D05963|PMID:15984785|PMID:19544990|HMDB:HMDB0001448|PMID:17439666|PMID:11798107|PMID:18815700|PMID:11452993|PMID:11581495|PMID:16347366|PMID:16483812|PMID:17709180|PMID:19628332	hp.json	SULFATE ION|Sulfate|tetraoxosulfate(VI)|sulphate|Sulfate dianion|Sulfate(2-)|SO4(2-)|Sulfuric acid ion(2-)|Sulfate anion(2-)|sulfate|tetraoxosulfate(2-)|sulphate ion|[SO4](2-)|sulfate|tetraoxidosulfate(2-)	http://purl.obolibrary.org/obo/CHEBI_16189		3_STAR
HP:0025580	biolink:PhenotypicFeature	Abnormal right atrium morphology	Any structural abnormality of the right atrium.	Fyler:1770	hp.json		http://purl.obolibrary.org/obo/HP_0025580		
HP:0025581	biolink:PhenotypicFeature	Foveal hemorrhage	Bleeding occurring within the fovea.		hp.json	Foveal haemorrhage	http://purl.obolibrary.org/obo/HP_0025581		
HP:0025582	biolink:PhenotypicFeature	Submacular hemorrhage	Bleeding between the neurosensory retina and the retinal pigment epithelium (RPE) arising from the choroidal or retinal circulation.		hp.json	Sub-macular haemorrhage|Submacular haemorrhage|Sub-macular hemorrhage	http://purl.obolibrary.org/obo/HP_0025582		
HP:0025583	biolink:PhenotypicFeature	Tapetal-like fundal reflex	Golden, scintillating, particulate reflection noted on fundus examination (typically in the macula and sparing the fovea). The term tapetal is used to describe this 'metallic' sheen appearance as it is thought to be similar to the 'tapetal' reflex seen in the eyes of certain animals.		hp.json		http://purl.obolibrary.org/obo/HP_0025583		
HP:0025584	biolink:PhenotypicFeature	Hypotropia	A form of manifest strabismus (heterotropia) in which one eye is deviated downwards when both eyes are open.		hp.json		http://purl.obolibrary.org/obo/HP_0025584		
CHEBI:16137	biolink:ChemicalSubstance	chondroitin D-glucuronate	A mucopolysaccharide composed of repeating beta-D-glucopyranuronosyl-(1->3)-beta-D-N-acetylgalactosaminyl units.	KEGG:G11334|KEGG:C00401	hp.json	Chondroitin|Chondroitin-D-glucuronate	http://purl.obolibrary.org/obo/CHEBI_16137		3_STAR
CHEBI:16135	biolink:ChemicalSubstance	isobutyric acid	A branched fatty acid comprising propanoic acid carrying a methyl branch at C-2.	LIPID_MAPS_instance:LMFA01020071|CAS:79-31-2|Beilstein:635770|PMID:17877388|Reaxys:635770|MetaCyc:ISOBUTYRATE|Wikipedia:Isobutyric_acid|KNApSAcK:C00029462|HMDB:HMDB0001873|CAS:79-31-2|CAS:79-31-2|PMID:17580301|PMID:10757489|Gmelin:49630|DrugBank:DB02531|UM-BBD_compID:c0383|BPDB:3128|PDBeChem:ALQ|KEGG:C02632|PPDB:3128	hp.json	Isobutyric acid|alpha-methylpropanoic acid|2,2-dimethylacetic acid|ISOBUTYRIC ACID|Isobuttersaeure|2-Methylpropanoic acid|isobutanoic acid|Dimethylacetic acid|Isobutyrate|alpha-methylpropionic acid|2-Methylpropanoate|2-METHYL-PROPIONIC ACID|iso-C3H7COOH|Isobutanoate|iso-butyric acid|alpha-isobutyric acid|2-methylpropanoic acid|2-Methylpropionsaeure|isopropylformic acid	http://purl.obolibrary.org/obo/CHEBI_16135		3_STAR
CHEBI:16134	biolink:ChemicalSubstance	ammonia	An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms.	PMID:22240068|PMID:11540049|PMID:16349403|KNApSAcK:C00007267|PMID:17025297|PMID:15092448|PMID:17737668|PMID:11783653|PMID:17439666|PMID:22130175|PMID:11139349|PMID:22560242|PMID:22002069|PMID:11746427|PMID:22290316|Gmelin:79|KEGG:D02916|MolBase:930|PMID:14663195|MetaCyc:AMMONIA|PMID:15969015|PMID:13753780|CAS:7664-41-7|Beilstein:3587154|Wikipedia:Ammonia|Reaxys:3587154|Drug_Central:4625|PMID:16664306|PMID:16008360|PMID:18670398|PMID:16842901|PMID:22342082|PDBeChem:NH3|PMID:22100291|HMDB:HMDB0000051|PMID:16050680|PMID:15094021|CAS:7664-41-7|PMID:22385337|PMID:22443779|CAS:7664-41-7|PMID:15554424|KEGG:C00014|PMID:22150211|PMID:22088435|PMID:16348008|PMID:110589|PMID:17569513|PMID:16614889|PMID:22081570	hp.json	ammonia|NH3|NH3|Ammoniak|spirit of hartshorn|Ammonia|R-717|azane|NH3|AMMONIA|amoniaco|[NH3]|ammoniac	http://purl.obolibrary.org/obo/CHEBI_16134		3_STAR
UBERON:0006355	biolink:AnatomicalEntity	superior vesical vein		EMAPA:18646|MA:0002227	hp.json		http://purl.obolibrary.org/obo/UBERON_0006355		human_reference_atlas
PR:000005794	biolink:Protein	ceruloplasmin	A protein that is a translation product of the human CP gene or a 1:1 ortholog thereof.		hp.json	ferroxidase|CP	http://purl.obolibrary.org/obo/PR_000005794		
UBERON:0006356	biolink:AnatomicalEntity	epigastric vein	A vein that drains the anterior abdominal wall.	UMLS:C1707930|EMAPA:18759|MA:0002114|NCIT:C53045	hp.json		http://purl.obolibrary.org/obo/UBERON_0006356		
UBERON:0018321	biolink:AnatomicalEntity	foramen for glossopharyngeal nerve	Foramen that allows the passge of the glossopharyngeal nerve (cranial nerve IX).	UBERONTEMP:9ca0bda7-9111-4f59-bc72-5d47bc3d7d61	hp.json		http://purl.obolibrary.org/obo/UBERON_0018321		
PR:P01308	biolink:Protein	insulin gene translation product (human)	An insulin gene translation product that is encoded in the genome of human.	UniProtKB:P01308	hp.json	hINS	http://purl.obolibrary.org/obo/PR_P01308		
UBERON:0018326	biolink:AnatomicalEntity	ilioischiadic foramen	Situated just caudal to the acetabulum, the foramen is bound dorsally by the illium and ventrally by the ischium. The foramen transmitts the ischiadic nerves and vessels (Baumel et al. 1993).	UBERONTEMP:63e09c69-ac98-49ba-b232-2da5c7b19019	hp.json		http://purl.obolibrary.org/obo/UBERON_0018326		
UBERON:0006340	biolink:AnatomicalEntity	fourth ventricle choroid plexus stroma	A choroid plexus stroma that is part of a fourth ventricle.	MA:0000985	hp.json		http://purl.obolibrary.org/obo/UBERON_0006340		
UBERON:0006349	biolink:AnatomicalEntity	epigastric artery	An external iliac artery branch that supplies blood to the anterior abdominal wall.	EMAPA:18750|MA:0001948|UMLS:C0282640|NCIT:C52860|MESH:D019074	hp.json		http://purl.obolibrary.org/obo/UBERON_0006349		
UBERON:0006347	biolink:AnatomicalEntity	communicating artery	An artery that connects two larger arteries.	MA:0001938|UMLS:C1707451|NCIT:C52851|EMAPA:18598	hp.json		http://purl.obolibrary.org/obo/UBERON_0006347		
CHEBI:28115	biolink:ChemicalSubstance	methylcobalamin		PDBeChem:COB|Gmelin:124528|KEGG:D03246|DrugBank:DB03614|KEGG:C06453|CAS:13422-55-4|CAS:13422-55-4|COMe:MOL000085	hp.json	mecobalamin|CO-METHYLCOBALAMIN|Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-methylcobamide|methylcobalamin|Methylcobalamin|methylcob(III)alamin|MeCbl	http://purl.obolibrary.org/obo/CHEBI_28115		3_STAR
UBERON:0006333	biolink:AnatomicalEntity	snout		ZFA:0005496|MA:0001910|TAO:0001712|EMAPA:32806	hp.json	muzzle	http://purl.obolibrary.org/obo/UBERON_0006333		vertebrate_core
UBERON:0008998	biolink:AnatomicalEntity	vasculature of brain	System pertaining to blood vessels in the brain.	ZFA:0000099|TAO:0000099|FMA:242007|BTO:0003840|FMA:61935|SCTID:362029003|EFO:0003491|EMAPA:35186	hp.json	brain vasculature|intracerebral vasculature|cerebrovascular system	http://purl.obolibrary.org/obo/UBERON_0008998		efo_slim
UBERON:0006331	biolink:AnatomicalEntity	brainstem nucleus	A nucleus of brain that is part of a brainstem.	MA:0000821|EMAPA:32790	hp.json	brain stem nucleus	http://purl.obolibrary.org/obo/UBERON_0006331		
UBERON:0006339	biolink:AnatomicalEntity	third ventricle choroid plexus stroma	A choroid plexus stroma that is part of a third ventricle.	MA:0000881|EMAPA:37056	hp.json		http://purl.obolibrary.org/obo/UBERON_0006339		
UBERON:0006338	biolink:AnatomicalEntity	lateral ventricle choroid plexus stroma	A choroid plexus stroma that is part of a lateral ventricle.	MA:0000963	hp.json		http://purl.obolibrary.org/obo/UBERON_0006338		
UBERON:0008995	biolink:AnatomicalEntity	nucleus of cerebellar nuclear complex	Four accumulations of gray substance embedded in the white substance of the cerebellum, comprising the nucleus dentatus, nucleus emboliformis, nucleus globosus, and nucleus fastigii.	BTO:0003835|FMA:321695|MA:0000203|EMAPA:35272	hp.json	cerebellar nucleus|deep cerebellar nucleus	http://purl.obolibrary.org/obo/UBERON_0008995		pheno_slim
HP:0025538	biolink:PhenotypicFeature	Palmar edema	An abnormal accumulation of fluid beneath the skin on the palm of the hand.		hp.json	Palmar oedema	http://purl.obolibrary.org/obo/HP_0025538		
HP:0025539	biolink:PhenotypicFeature	Abnormal B cell subset distribution			hp.json		http://purl.obolibrary.org/obo/HP_0025539		
HP:0001563	biolink:PhenotypicFeature	Fetal polyuria	Abnormally increased production of urine by the fetus resulting in polyhydramnios.	UMLS:C1865279	hp.json	Foetal polyuria	http://purl.obolibrary.org/obo/HP_0001563		
HP:0025530	biolink:PhenotypicFeature	Xanthomas of the palmar creases	The presence of multiple xanthomas (xanthomata) in the skin distributed in the creases of the palm of the hand. Xanthomas are yellowish, firm, lipid-laden nodules in the skin.		hp.json	Xanthoma striatum palmare|Xanthoma palmare striatum	http://purl.obolibrary.org/obo/HP_0025530		
HP:0025531	biolink:PhenotypicFeature	Harlequin phenomenon	The Harlequin phenomenon consists of a sudden change in skin colour, resulting in two different body colours, one on each half of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0025531		
HP:0001561	biolink:PhenotypicFeature	Polyhydramnios	The presence of excess amniotic fluid in the uterus during pregnancy.	MSH:D006831|SNOMEDCT_US:86203003|UMLS:C0020224	hp.json	Increased amniotic fluid index|Hydramnios|High levels of amniotic fluid	http://purl.obolibrary.org/obo/HP_0001561		
HP:0025532	biolink:PhenotypicFeature	Positive pathergy test	With the pathergy test, a small, sterile needle is inserted into the skin of the forearm. The site of injectionis circuled and observed after one and two days. If a small red bump or pustule at the site of needle insertion occurs, the pathergy test is considered to have a positive (abnormal) result.		hp.json		http://purl.obolibrary.org/obo/HP_0025532		
HP:0025533	biolink:PhenotypicFeature	Peau d'orange			hp.json		http://purl.obolibrary.org/obo/HP_0025533		
HP:0001562	biolink:PhenotypicFeature	Oligohydramnios	Diminished amniotic fluid volume in pregnancy.	MSH:D016104|SNOMEDCT_US:59566000|UMLS:C3550658|UMLS:C0079924	hp.json	Maternal oligohydramnios|Decreased amniotic fluid index|Low levels of amniotic fluid	http://purl.obolibrary.org/obo/HP_0001562		
HP:0025534	biolink:PhenotypicFeature	Ocular melanocytosis	A congenital lesion of the sclera characterized by unilateral patchy but extensive slate-gray or bluish discoloration of the sclera . The conjunctiva are spared.		hp.json	Melanosis oculi|Ocular melanosis	http://purl.obolibrary.org/obo/HP_0025534		
HP:0025535	biolink:PhenotypicFeature	Shawl sign	Erythematous, poikilodermatous macules distributed in a shawl pattern over the shoulders, arms and upper back.		hp.json		http://purl.obolibrary.org/obo/HP_0025535		
HP:0025536	biolink:PhenotypicFeature	V-sign	Erythematous, poikilodermatous macules distributed in a V-shaped distribution over the anterior neck and chest.		hp.json		http://purl.obolibrary.org/obo/HP_0025536		
GO:0016469	biolink:CellularComponent	proton-transporting two-sector ATPase complex	A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.		hp.json	hydrogen-transporting two-sector ATPase complex|vacuolar hydrogen-transporting ATPase	http://purl.obolibrary.org/obo/GO_0016469		goslim_pir|goslim_metagenomics
HP:0001566	biolink:PhenotypicFeature	Widely-spaced maxillary central incisors	Increased distance between the maxillary central permanent incisor tooth.	UMLS:C1835762|UMLS:C4280252|UMLS:C1845110	hp.json	Widely spaced upper incisors|Wide upper central incisors|Diastema between maxillary central incisors|Gap between upper front teeth|Diastema between upper front teeth|Wide gap between upper central incisors|Diastasis of the central incisors|Separated superior central incisors|Diastema between upper incisors|Central incisor gap	http://purl.obolibrary.org/obo/HP_0001566		
HP:0025537	biolink:PhenotypicFeature	Plantar edema	An abnormal accumulation of fluid beneath the skin on sole of the foot.		hp.json	Plantar oedema	http://purl.obolibrary.org/obo/HP_0025537		
HP:0001560	biolink:PhenotypicFeature	Abnormality of the amniotic fluid	Abnormality of the amniotic fluid, which is the fluid contained in the amniotic sac surrounding the developing fetus.	UMLS:C0266781|SNOMEDCT_US:42170009	hp.json	Abnormal amniotic fluid	http://purl.obolibrary.org/obo/HP_0001560		
HP:0025527	biolink:PhenotypicFeature	Serpiginous cutaneous lesion	A skin lesion with a snake- or serpent-like distribution.		hp.json	Serpiginous eruption	http://purl.obolibrary.org/obo/HP_0025527		
GO:0004494	biolink:MolecularActivity	methylmalonyl-CoA mutase activity	Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.	RHEA:22888|MetaCyc:METHYLMALONYL-COA-MUT-RXN|Reactome:R-HSA-71010|UM-BBD_reactionID:r0922|EC:5.4.99.2|Reactome:R-HSA-3322971|KEGG_REACTION:R00833	hp.json	(R)-methylmalonyl-CoA CoA-carbonylmutase activity|(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity|methylmalonyl-CoA CoA-carbonyl mutase activity|(S)-methylmalonyl-CoA mutase activity|methylmalonyl coenzyme A mutase activity|methylmalonyl coenzyme A carbonylmutase activity	http://purl.obolibrary.org/obo/GO_0004494		
HP:0025528	biolink:PhenotypicFeature	Annular cutaneous lesion	A lesion of the skin with a ring-like distribution.		hp.json		http://purl.obolibrary.org/obo/HP_0025528		
HP:0025529	biolink:PhenotypicFeature	Hyperpigmented nodule	A nodule of the skin that exhibits an increased amount of pigmentation.		hp.json		http://purl.obolibrary.org/obo/HP_0025529		
HP:0001574	biolink:PhenotypicFeature	Abnormality of the integument	An abnormality of the integument, which consists of the skin and the superficial fascia.	UMLS:C4025761	hp.json		http://purl.obolibrary.org/obo/HP_0001574		
HP:0025520	biolink:PhenotypicFeature	Calcinosis cutis	Deposition of calcium in the skin.		hp.json	Cutaneous calcification	http://purl.obolibrary.org/obo/HP_0025520		
HP:0001575	biolink:PhenotypicFeature	obsolete Mood changes			hp.json		http://purl.obolibrary.org/obo/HP_0001575		
HP:0001572	biolink:PhenotypicFeature	Macrodontia	Increased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD above mean for age. Alternatively, an apparently increased maximum width of the tooth.	UMLS:C0266036|UMLS:C4280592|UMLS:C4280591|SNOMEDCT_US:71485000|UMLS:C4280590	hp.json	Hyperplasia of tooth|Tooth mass excess|Large tooth|Increased size of tooth|Hypertrophy of tooth|Megalodontia|Increased width of tooth	http://purl.obolibrary.org/obo/HP_0001572		hposlim_core
HP:0025521	biolink:PhenotypicFeature	Increased body fat percentage	The percentage of fat as a part of total body weight above the norm, usually defined as 32% for females and 25% for males.		hp.json		http://purl.obolibrary.org/obo/HP_0025521		
HP:0025522	biolink:PhenotypicFeature	Elongated chordae tendinae of the mitral valve	Abnormal increased in length of the chordae tendinae of the mitral valve.		hp.json		http://purl.obolibrary.org/obo/HP_0025522		
GO:0016477	biolink:BiologicalProcess	cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.	Wikipedia:Cell_migration	hp.json		http://purl.obolibrary.org/obo/GO_0016477		
HP:0025523	biolink:PhenotypicFeature	Abnormal morphology of the chordae tendinae of the mitral valve	A structural anomaly of the chordae tendinae of the mitral valve, whose main function is to transmit the contraction and relaxation of the papillary muscles during the cardiac cycle, thus ensuring the closing of the leaflets of the mitral valve.		hp.json		http://purl.obolibrary.org/obo/HP_0025523		
HP:0025524	biolink:PhenotypicFeature	Palmoplantar scaling skin	Loss of the outer layer of the epidermis in large, scale-like flakes localized to the palm of the hand and the sole of the foot.		hp.json	Palmoplantar psoriasis	http://purl.obolibrary.org/obo/HP_0025524		
HP:0001579	biolink:PhenotypicFeature	Primary hypercortisolism	Hypercortisolemia associated with a primary defect of the adrenal gland leading to overproduction of cortisol.	UMLS:C4025760|UMLS:C1968852	hp.json	ACTH-independent hypercortisolemia	http://purl.obolibrary.org/obo/HP_0001579		
HP:0025525	biolink:PhenotypicFeature	Scaling skin on fingertip	Loss of the outer layer of the epidermis in large, scale-like flakes localized to one or more fingertips.		hp.json		http://purl.obolibrary.org/obo/HP_0025525		
HP:0025526	biolink:PhenotypicFeature	Psoriasiform lesion	A skin lesions that resembles the lesions observed in psoriasis, viz., an erythematous plaque covered by fine silvery scales. Psoriasiform lesions can be observed in psoriasis as well as in other conditions including allergic contact dermatitis, seborrhoeic dermatitis, Atopic dermatitis, pityriasis rubra, and lichen simplex chronicus.		hp.json	Psoriatic-like lesion|Erythematosquamous plaque|Erythemato-squamous plaque	http://purl.obolibrary.org/obo/HP_0025526		
PR:P50283	biolink:Protein	T-cell antigen CD7 (mouse)	A CD7 molecule that is encoded in the genome of mouse.	UniProtKB:P50283	hp.json	mCD7|CD7 (mouse)|Cd7	http://purl.obolibrary.org/obo/PR_P50283		
HP:0001571	biolink:PhenotypicFeature	Multiple impacted teeth	The presence of multiple impacted teeth.	UMLS:C1839965|UMLS:C4280593	hp.json	Multiple retained teeth|Multiple impacted teeth|Impacted teeth|Multiple buried teeth	http://purl.obolibrary.org/obo/HP_0001571		
HP:0025516	biolink:PhenotypicFeature	Coronary-pulmonary artery fistula	A congenital malformation with abnormal connection between one of the coronary arteries and the pulmonary artery.		hp.json		http://purl.obolibrary.org/obo/HP_0025516		
HP:0001549	biolink:PhenotypicFeature	Abnormal ileum morphology		UMLS:C4025762	hp.json	Abnormality of the ileum	http://purl.obolibrary.org/obo/HP_0001549		
HP:0025517	biolink:PhenotypicFeature	Hypoplastic hippocampus	Underdevelopment of the hippocampus.		hp.json	Underdeveloped hippocampus|Small hippocampus	http://purl.obolibrary.org/obo/HP_0025517		
HP:0025518	biolink:PhenotypicFeature	Visual gaze preference	An abnormality of gaze that can be observed following an acute supranuclear cerebral lesion (e.g., stroke) that is characterized by an acute inability to direct gaze contralateral to the side of the lesion and is accompanied by a tendency for tonic deviation of the eyes toward the side of the lesion.		hp.json		http://purl.obolibrary.org/obo/HP_0025518		
HP:0001547	biolink:PhenotypicFeature	Abnormal rib cage morphology	A morphological anomaly of the rib cage.	UMLS:C4025763	hp.json	Abnormality of the rib cage	http://purl.obolibrary.org/obo/HP_0001547		
HP:0001548	biolink:PhenotypicFeature	Overgrowth	Excessive postnatal growth which may comprise increased weight, increased length, and/or increased head circumference.	UMLS:C1849265|UMLS:C3150281|UMLS:C1851731	hp.json	Generalized overgrowth|General overgrowth|Generalised overgrowth	http://purl.obolibrary.org/obo/HP_0001548		
HP:0025519	biolink:PhenotypicFeature	Multiple biliary hamartomas	Multiple biliary hamartomas are a rare clinicopathologic entity, consisting of small (less than 1.5cm), usually multiple and nodular cystic lesions in the liver.		hp.json	Von Meyenburg complexes|Biliary hamartoma|Multiple bile duct hamartomas	http://purl.obolibrary.org/obo/HP_0025519		
HP:0001541	biolink:PhenotypicFeature	Ascites	Accumulation of fluid in the peritoneal cavity.	MSH:D001201|SNOMEDCT_US:389026000|UMLS:C0003962	hp.json	Accumulation of fluid in the abdomen	http://purl.obolibrary.org/obo/HP_0001541		hposlim_core
HP:0025510	biolink:PhenotypicFeature	Nevus spilus	A tan, regularly bordered patch with darker macules within the lesion.		hp.json	Speckled lentiginous Nevus	http://purl.obolibrary.org/obo/HP_0025510		
HP:0025511	biolink:PhenotypicFeature	Nevus sebaceus	A solitary yellow-orange slightly raised plaque typically on scalp or face. The plaque typically thickens and becomes more verrucous or pebbly during childhood.		hp.json		http://purl.obolibrary.org/obo/HP_0025511		
HP:0001540	biolink:PhenotypicFeature	Diastasis recti	A separation of the rectus abdominis muscle into right and left halves (which are normally joined at the midline at the linea alba).	UMLS:C0221766|SNOMEDCT_US:62629000	hp.json	Gap between large left and right abdominal muscles	http://purl.obolibrary.org/obo/HP_0001540		hposlim_core
HP:0001545	biolink:PhenotypicFeature	Anteriorly placed anus	Anterior malposition of the anus.	UMLS:C1838705	hp.json	Anus anteposition|Anteriorly displaced anus	http://purl.obolibrary.org/obo/HP_0001545		hposlim_core
HP:0025512	biolink:PhenotypicFeature	Skin-colored papule	A papule with the same color as the surrounding skin.		hp.json	Flesh-colored papule	http://purl.obolibrary.org/obo/HP_0025512		
HP:0025513	biolink:PhenotypicFeature	Scleral rupture	Breakage of the sclera.		hp.json		http://purl.obolibrary.org/obo/HP_0025513		
HP:0025514	biolink:PhenotypicFeature	Morning glory anomaly	An abnormality of the optic nerve in which the optic nerve is large and funneled and displays a conical excavation of the optic disc. The optic disc appears dysplastic.		hp.json	Morning glory optic disc|Morning glory disc anomaly	http://purl.obolibrary.org/obo/HP_0025514		
HP:0001543	biolink:PhenotypicFeature	Gastroschisis	A type of congenital ventral incomplete closure of the abdominal wall in which the intestines and sometimes other organs extend freely into the amniotic fluid space through a small opening in the abdomen, usually to the right of the umbilicus.	MSH:D020139|MEDDRA:10018046|UMLS:C0265706|SNOMEDCT_US:72951007	hp.json		http://purl.obolibrary.org/obo/HP_0001543		hposlim_core
HP:0001544	biolink:PhenotypicFeature	Prominent umbilicus	Abnormally prominent umbilicus (belly button).	UMLS:C1837795	hp.json	Prominent belly button|Prominent navel	http://purl.obolibrary.org/obo/HP_0001544		
HP:0025515	biolink:PhenotypicFeature	Delayed thelarche	Later than normal development of the breasts.		hp.json		http://purl.obolibrary.org/obo/HP_0025515		
HP:0025505	biolink:PhenotypicFeature	Anomalous origin of the circumflex artery from the right sinus of Valsalva	The circumflex coronary artery originates from the right aortic sinus of Valsalva.		hp.json		http://purl.obolibrary.org/obo/HP_0025505		
HP:0025506	biolink:PhenotypicFeature	Coronary artery sandwich anomaly	Origin of the right coronary artery (RCA) from the left sinus of Valsalva or of the left main (LM) or left anterior descending (LAD) coronary artery from the right sinus of Valsalva, with the additional feature that the artery passes between the two great arteries. This carries a risk of the artery being compressed by these two vessels,		hp.json	Anomalous coronary artery with aortic origin and course between the great arteries	http://purl.obolibrary.org/obo/HP_0025506		
HP:0025507	biolink:PhenotypicFeature	Yellow papule	A papule with yellow color.		hp.json	Yellow-orange papule	http://purl.obolibrary.org/obo/HP_0025507		
HP:0001558	biolink:PhenotypicFeature	Decreased fetal movement	An abnormal reduction in quantity or strength of fetal movements.	UMLS:C0235659|SNOMEDCT_US:276369006	hp.json	Decreased foetal movement|Decreased foetal activity|Reduced fetal movements|Decreased foetal movements|Reduced fetal movement|Dminished fetal movement|Decreased movement in utero|Less than 10 foetal movements in 12 hours|Reduced foetal movement|Foetal hypokinesia|Reduced foetal movements|Decreased fetal movements|Decreased fetal activity|Less than 10 fetal movements in 12 hours|Fetal hypokinesia	http://purl.obolibrary.org/obo/HP_0001558		
HP:0025508	biolink:PhenotypicFeature	Gottron's papules	Violaceous papules overlying the dorsal and lateral aspects of the metacarpophalangeal and proximal interphalangeal joints.		hp.json	Gottron papules	http://purl.obolibrary.org/obo/HP_0025508		
HP:0025509	biolink:PhenotypicFeature	Piezogenic pedal papules	Flesh-colored or yellowish papules, 2 mm or larger, that are responses to internal mechanical pressure and weakness in the connective tissue in the dermis, appear commonly over the medial aspect of the heel, but in some cases on the wrists. They are thought to represent herniations of adipose tissue through the plantar fascia retinaculum.		hp.json		http://purl.obolibrary.org/obo/HP_0025509		
HP:0001552	biolink:PhenotypicFeature	Barrel-shaped chest	A rounded, bulging chest that resembles the shape of a barrel. That is, there is an increased anteroposterior diameter and usually some degree of kyphosis.	UMLS:C0264172|SNOMEDCT_US:24228002	hp.json	Barrel chest|Barrel-shaped chest	http://purl.obolibrary.org/obo/HP_0001552		hposlim_core
HP:0001551	biolink:PhenotypicFeature	Abnormal umbilicus morphology	An abnormality of the structure or appearance of the umbilicus.	UMLS:C1849338	hp.json	Abnormal belly button|Abnormal umbilicus|Abnormal navel	http://purl.obolibrary.org/obo/HP_0001551		
HP:0025500	biolink:PhenotypicFeature	Class II obesity	Obesity with a body mass index of 35 to 39.9 kg per square meter.		hp.json	Obesity grade 2	http://purl.obolibrary.org/obo/HP_0025500		
HP:0025501	biolink:PhenotypicFeature	Class III obesity	Obesity with a body mass index of 40 kg per square meter or higher.		hp.json	Obesity grade 3	http://purl.obolibrary.org/obo/HP_0025501		
HP:0001557	biolink:PhenotypicFeature	Prenatal movement abnormality	An abnormality of fetal movement.	UMLS:C1849510	hp.json	Abnormal intrauterine movements	http://purl.obolibrary.org/obo/HP_0001557		
HP:0025502	biolink:PhenotypicFeature	Overweight	Increased body weight with a body mass index of 25-29.9 kg per square meter.		hp.json		http://purl.obolibrary.org/obo/HP_0025502		
HP:0025503	biolink:PhenotypicFeature	Anomalous coronary artery arising from the opposite sinus	Origin of the right coronary artery (RCA) from the left sinus of Valsalva or of the left main (LM) or left anterior descending (LAD) coronary artery from the right sinus of Valsalva.		hp.json		http://purl.obolibrary.org/obo/HP_0025503		
HP:0001555	biolink:PhenotypicFeature	Asymmetry of the thorax	Lack of symmetry between the left and right halves of the thorax.	UMLS:C1858033	hp.json	Asymmetric chest	http://purl.obolibrary.org/obo/HP_0001555		hposlim_core
HP:0025574	biolink:PhenotypicFeature	Macular hemorrhage	Bleeding occurring within the macula lutea of the retina.		hp.json	Macular haemorrhage	http://purl.obolibrary.org/obo/HP_0025574		
HP:0025575	biolink:PhenotypicFeature	Abnormal superior vena cava morphology	Any structural anomaly of the principal vein draining blood from the upper portion of the body and delivering it to the right ventricle of the heart.	Fyler:2820	hp.json		http://purl.obolibrary.org/obo/HP_0025575		
HP:0025576	biolink:PhenotypicFeature	Abnormal inferior vena cava morphology	Any structural anomaly of the principal vein draining blood from the lower portion of the body.	Fyler:2810	hp.json		http://purl.obolibrary.org/obo/HP_0025576		
HP:0025578	biolink:PhenotypicFeature	Aortic valve prolapse	Aortic valve prolapse can be diagnosed when either or both of the right or non-coronary aortic valve cusps (seen in the cross sectional echocardiographic long axis view) show backward bowing towards the left ventricle beyond a line joining the points of attachment of the aortic valve leaflets to the annulus.	Fyler:1452	hp.json		http://purl.obolibrary.org/obo/HP_0025578		
UBERON:0008946	biolink:AnatomicalEntity	lung parenchyma	A parenchyma that is part of a lung.	EMAPA:35522|SCTID:201712001|MA:0003168|FMA:27360	hp.json	pulmonary parenchyma|parenchyma of lung|respiratory portion of lung	http://purl.obolibrary.org/obo/UBERON_0008946		
HP:0025579	biolink:PhenotypicFeature	Abnormal left atrium morphology	Any structural abnormality of the left atrium.	Fyler:3010	hp.json		http://purl.obolibrary.org/obo/HP_0025579		
UBERON:0008947	biolink:AnatomicalEntity	respiratory primordium		NCIT:C34283|UMLS:C1514898|EHDAA2:0004069	hp.json		http://purl.obolibrary.org/obo/UBERON_0008947		
GO:0016421	biolink:MolecularActivity	CoA carboxylase activity	Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.		hp.json		http://purl.obolibrary.org/obo/GO_0016421		
HP:0025570	biolink:PhenotypicFeature	Choroidal vascular hyperpermeability	Increased tendency of choiroidal blood vessels to allow fluids to leak characterized by multifocal choroidal hyperfluorescence on indocyanine green angiography (ICGA).		hp.json	Choroidal hyperpermeability	http://purl.obolibrary.org/obo/HP_0025570		
HP:0025571	biolink:PhenotypicFeature	Christmas tree cataract	A type of cataract that shows a spectacular display of multiple colours that glitters with the change of incident light like an illuminated Christmas tree.		hp.json		http://purl.obolibrary.org/obo/HP_0025571		
HP:0025572	biolink:PhenotypicFeature	Punctal stenosis	Punctal stenosis is a condition in which the external opening of the lacrimal canaliculus is narrowed or occluded.		hp.json	Stenosis of the lacrimal punctum|Lacrimal punctum stenosis	http://purl.obolibrary.org/obo/HP_0025572		
HP:0025573	biolink:PhenotypicFeature	Mild myopia	A mild form of myopia with up to -3.00 diopters.		hp.json		http://purl.obolibrary.org/obo/HP_0025573		
HP:0025563	biolink:PhenotypicFeature	Anterior chamber cells grade 0	Anterior chamber cells with less than one cell in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.		hp.json		http://purl.obolibrary.org/obo/HP_0025563		
HP:0025564	biolink:PhenotypicFeature	Anterior chamber cells grade 2+	Anterior chamber cells with 16-25 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.		hp.json		http://purl.obolibrary.org/obo/HP_0025564		
HP:0025565	biolink:PhenotypicFeature	Anterior chamber cells grade 3+	Anterior chamber cells with 26-50 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.		hp.json		http://purl.obolibrary.org/obo/HP_0025565		
HP:0025566	biolink:PhenotypicFeature	Anterior chamber cells grade 4+	Anterior chamber cells with more than 50 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.		hp.json		http://purl.obolibrary.org/obo/HP_0025566		
HP:0025567	biolink:PhenotypicFeature	Central serous chorioretinopathy	An anomaly of the retina with serous detachment of the neurosensory retina secondary to one or more focal lesions of the retinal pigment epithelium (RPE), and associated with blurred vision, usually in one eye only and perceived typically by the patient as a dark spot in the centre of the visual field with associated micropsia and metamorphopsia. Normal vision often recurs spontaneously within a few months.		hp.json		http://purl.obolibrary.org/obo/HP_0025567		
HP:0025568	biolink:PhenotypicFeature	Abnormal morphology of the choroidal vasculature			hp.json		http://purl.obolibrary.org/obo/HP_0025568		
HP:0025569	biolink:PhenotypicFeature	Polypoidal choroidal vasculopathy	The presence of aneurysmal polypoidal lesions in the choroidal vasculature. The aneurysmal dilatations, also known as polyps, may be found at subfoveal, juxtafoveal, extrafoveal, peripapillary or even peripheral regions. These polypoidal dilatations may be visible as reddish-orange subretinal nodules during ophthalmoscopic examination. The polypoidal lesions are best detected on indocyanine green angiography (ICGA) and might be associated with a branching vascular network (BVN) of neovascularization.		hp.json		http://purl.obolibrary.org/obo/HP_0025569		
HP:0025560	biolink:PhenotypicFeature	Anterior chamber cells	Tiny deposits corresponding to cells floating in the anterior chamber of the eye. This appearance is typically associated with intraocular inflammation leading to breakdown of the blood-aqueous barrier and resulting in an increase in the number of cells and in the aqueous humor. Grading (SUN Working Group) is performed by estimating the number of cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.		hp.json		http://purl.obolibrary.org/obo/HP_0025560		
HP:0025561	biolink:PhenotypicFeature	Anterior chamber cells grade 1+	Anterior chamber cells with 6-15 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.		hp.json		http://purl.obolibrary.org/obo/HP_0025561		
HP:0025562	biolink:PhenotypicFeature	Anterior chamber cells grade 0.5+	Anterior chamber cells with 1-5 cells in a 1 mm by 1 mm slit beam field, employing adequate light intensity and magnification on a slit lamp.		hp.json		http://purl.obolibrary.org/obo/HP_0025562		
GO:0016409	biolink:MolecularActivity	palmitoyltransferase activity	Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule.	Reactome:R-HSA-203567|Reactome:R-HSA-5686304	hp.json		http://purl.obolibrary.org/obo/GO_0016409		
HP:0025552	biolink:PhenotypicFeature	Periorbital purpura	Multiple red/purple spots on the skin that surrounds the eyes that do not blanch (whiten) upon pressure. Purpura is caused by subcutaneous bleeding.		hp.json		http://purl.obolibrary.org/obo/HP_0025552		
HP:0001586	biolink:PhenotypicFeature	Vesicovaginal fistula	The presence of a fistula connecting the urinary bladder to the vagina.	UMLS:C0042582|MSH:D014719|SNOMEDCT_US:89405008	hp.json		http://purl.obolibrary.org/obo/HP_0001586		
HP:0025553	biolink:PhenotypicFeature	Periorbital ecchymosis with tarsal plate sparing	Subcutaneous bleeding with a diameter greater than 1 cm (ecchymosis). The bleeding does not extend into the tarsal plate (the comparatively thick, elongated plates of dense connective tissue within the eyelid) due to an anatomic structure called the orbital septum, which limits extravasation of blood beyond the tarsal plate.		hp.json	Raccoon eyes	http://purl.obolibrary.org/obo/HP_0025553		
HP:0001583	biolink:PhenotypicFeature	Rotary nystagmus	A form of nystagmus in which the eyeball makes rotary motions around the axis.	SNOMEDCT_US:95783006|SNOMEDCT_US:44526006|MSH:D009759|UMLS:C0240595	hp.json	Rotatory Nystagmus	http://purl.obolibrary.org/obo/HP_0001583		hposlim_core
HP:0025554	biolink:PhenotypicFeature	Yellow nodule	A type of skin nodule (a lesions that is greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat) with a yellowish coloration (that reflects a high lipid content of the lesion).		hp.json		http://purl.obolibrary.org/obo/HP_0025554		
GO:0016406	biolink:MolecularActivity	carnitine O-acyltransferase activity	Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule.		hp.json		http://purl.obolibrary.org/obo/GO_0016406		
HP:0025555	biolink:PhenotypicFeature	Periungual teleangiectasia	Telangiectasia (small dilated blood vessels) located near to the fingernails or toenails.		hp.json		http://purl.obolibrary.org/obo/HP_0025555		
HP:0025558	biolink:PhenotypicFeature	Lamellar cataract with riders	Lamellar cataracts with associated linear lens opacities radially extending towards the periphery of the lens.		hp.json		http://purl.obolibrary.org/obo/HP_0025558		
HP:0001587	biolink:PhenotypicFeature	obsolete Primary ovarian failure			hp.json		http://purl.obolibrary.org/obo/HP_0001587		
HP:0025559	biolink:PhenotypicFeature	Coronary cataract	A type of cataract characterised by club-shaped and dot opacities distributed radially in the deep cortex. These lens opacities surround the nucleus in an appearance that is though to resemble a crown.		hp.json		http://purl.obolibrary.org/obo/HP_0025559		
HP:0001581	biolink:PhenotypicFeature	Recurrent skin infections	Infections of the skin that happen multiple times.	UMLS:C1853193	hp.json	Cutaneous infections|Skin infections, recurrent|Recurrent skin infections	http://purl.obolibrary.org/obo/HP_0001581		
HP:0001582	biolink:PhenotypicFeature	Redundant skin	Loose and sagging skin often associated with loss of skin elasticity.	SNOMEDCT_US:201093004|UMLS:C0581342	hp.json	Redundant skin folds|Loose redundant skin|Sagging, redundant skin	http://purl.obolibrary.org/obo/HP_0001582		
HP:0025550	biolink:PhenotypicFeature	Elevated circulating ribitol concentration	An increase above the normal concentration of ribitol in the blood.		hp.json	Increased level of ribitol in serum	http://purl.obolibrary.org/obo/HP_0025550		
HP:0001580	biolink:PhenotypicFeature	Pigmented micronodular adrenocortical disease		UMLS:C1968851	hp.json		http://purl.obolibrary.org/obo/HP_0001580		
HP:0025551	biolink:PhenotypicFeature	Optic nerve misrouting	Abnormal decussation of the visual pathways, typically identified using visual evoked potentials (VEP) (asymmetrical distribution of the VEP over the posterior scalp).		hp.json	Optic pathway misrouting|Visual pathway misrouting	http://purl.obolibrary.org/obo/HP_0025551		
HP:0025549	biolink:PhenotypicFeature	Eccentric visual fixation	A uniocular condition in which there is fixation of an object by a point other than the fovea. This point adopts the principal visual direction. The degree of the eccentric fixation is defined by its distance from the fovea in degrees.		hp.json	Eccentric fixation	http://purl.obolibrary.org/obo/HP_0025549		
UBERON:0008907	biolink:AnatomicalEntity	dermal bone	Skeletal element that forms superficially in the organism, usually in association with the ectoderm[VSAO].	XAO:0004015|Wikipedia:Dermal_bone|ZFA:0001590|TAO:0001590|AAO:0010769|VSAO:0000130	hp.json	dermal bones	http://purl.obolibrary.org/obo/UBERON_0008907		
CHEBI:546807	biolink:ChemicalSubstance	beta-D-Galp-(1->3)-D-GalpNAc	An amino disaccharide consisting of D-galactopyranose at the non-reducing end joined by a (1->3) glycosidic linkage to N-acetyl-D-galactopyranosamine.	PMID:2584393|PMID:11294842|PMID:3360006|PMID:2055602|PMID:2470785|PMID:12472179|PMID:19506091|PMID:19443021|PMID:11459848|PMID:15963963|GlyTouCan:G78436BB|PMID:7757427|GlyGen:G78436BB|PMID:11425800|CAS:20972-29-6|PMID:2457603|PMID:19221437|PMID:16776550|PMID:19913595|KEGG:C07278|PMID:9405387|PMID:1291050|PMID:59831|Reaxys:4788642|Beilstein:4788642|PMID:28188832|PMID:2461959|KEGG:G10607|PMID:1933953	hp.json	TF epitope|beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine|beta-D-Galp-(1->3)-D-GalpNAc|WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1b_1-5]/1-2/a3-b1|beta-D-Galactopyranosyl-(1->3)-N-acetyl-D-galactosamine|2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-D-galactopyranose|2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-D-galactopyranose|Thomsen-Friedenreich epitope|beta-D-galactosyl-3-N-acetyl-D-galactosamine|(Gal)1 (GalNAc)1|beta-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-D-galactopyranose|Galbeta1-3GalNAc|beta-D-Gal-(1->3)-D-GalNAc|Galbeta1->3GalNAc	http://purl.obolibrary.org/obo/CHEBI_546807		3_STAR
UBERON:0008909	biolink:AnatomicalEntity	perichordal bone	Bone element that is adjacent to the notochord.	AAO:0010777|VSAO:0000307|ZFA:0001629|TAO:0001639	hp.json	perichordal bones|perichordal bone	http://purl.obolibrary.org/obo/UBERON_0008909		
HP:0001596	biolink:PhenotypicFeature	Alopecia	A noncongenital process of hair loss, which may progress to partial or complete baldness.	MSH:D000505|SNOMEDCT_US:278040002|SNOMEDCT_US:56317004|UMLS:C0002170|MEDDRA:10001760	hp.json	Hair loss	http://purl.obolibrary.org/obo/HP_0001596		hposlim_core
HP:0025541	biolink:PhenotypicFeature	obsolete Decreased activity of complement receptor			hp.json		http://purl.obolibrary.org/obo/HP_0025541		
HP:0001597	biolink:PhenotypicFeature	Abnormality of the nail	Abnormality of the nail.	SNOMEDCT_US:17790008|MSH:D009264|UMLS:C0853087|MSH:D009260|UMLS:C0027339	hp.json	Abnormality of the nail|Nail disease	http://purl.obolibrary.org/obo/HP_0001597		
GO:0016416	biolink:MolecularActivity	O-palmitoyltransferase activity	Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule.	Reactome:R-HSA-2404137|Reactome:R-HSA-2453855|Reactome:R-HSA-2466710	hp.json		http://purl.obolibrary.org/obo/GO_0016416		
HP:0001595	biolink:PhenotypicFeature	Abnormal hair morphology	An abnormality of the hair.	UMLS:C2677869|UMLS:C0157733	hp.json	Abnormality of the hair shaft|Abnormality of the hair|Hair abnormality	http://purl.obolibrary.org/obo/HP_0001595		hposlim_core
HP:0025546	biolink:PhenotypicFeature	Abnormal mean corpuscular hemoglobin concentration	A deviation from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced.		hp.json	Abnormal mean corpuscular haemoglobin|Abnormal mean corpuscular haemoglobin concentration|Abnormal MCH|Abnormal MCHC|Abnormal mean corpuscular Hb concentration	http://purl.obolibrary.org/obo/HP_0025546		
HP:0001598	biolink:PhenotypicFeature	Concave nail	The natural longitudinal (posterodistal) convex arch is not present or is inverted.	UMLS:C0221261|SNOMEDCT_US:66270006	hp.json	Spoon-shaped nails|Koilonychia	http://purl.obolibrary.org/obo/HP_0001598		hposlim_core
HP:0025547	biolink:PhenotypicFeature	Decreased mean corpuscular hemoglobin concentration	A reduction from the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell). A reduced mean corpuscular hemoglobin (MCH) may indicate a hypochromic anemia, but the MCH may be normal if both the total hemoglobin and the red blood cell count are reduced.		hp.json	Decreased mean corpuscular Hb concentration|Decreased mean corpuscular haemoglobin|Decreased mean corpuscular haemoglobin concentration|Decreased MCHC|Decreased MCH	http://purl.obolibrary.org/obo/HP_0025547		
HP:0025548	biolink:PhenotypicFeature	Increased mean corpuscular hemoglobin concentration	An elevation over the normal range of the average amount of hemoglobin per red blood cell (27 to 31 picograms/cell).		hp.json	Increased mean corpuscular haemoglobin concentration|Increased MCH|Increased mean corpuscular Hb concentration|Increased MCHC|Increased mean corpuscular haemoglobin	http://purl.obolibrary.org/obo/HP_0025548		
HP:0001592	biolink:PhenotypicFeature	Selective tooth agenesis	Agenesis specifically affecting one of the classes incisor, premolar, or molar.	UMLS:C1970308|UMLS:C4280251	hp.json	Absence of a tooth|Agenesis of a tooth|Failure of development of a tooth|Missing a tooth	http://purl.obolibrary.org/obo/HP_0001592		
HP:0001593	biolink:PhenotypicFeature	Maxillary lateral incisor microdontia	Decreased size of the maxillary permanent incisor.	UMLS:C4280589|UMLS:C4280588|UMLS:C1845111	hp.json	Decreased width of upper lateral incisor|Hypotrophic maxillary lateral incisor|Hypotrophic upper lateral incisor|Decreased size of maxillary lateral incisor|Decreased size of upper lateral incisor|Small maxillary lateral incisor|Small upper lateral incisor	http://purl.obolibrary.org/obo/HP_0001593		
HP:0001591	biolink:PhenotypicFeature	Bell-shaped thorax	The rib cage has the shape of a wide mouthed bell. That is, the superior portion of the rib cage is constricted, followed by a convex region, and the inferior portion of the rib cage expands again to have a large diameter.	UMLS:C1865186	hp.json	Narrow, bell-shaped thorax|Constricted, bell-shaped thorax|Bell-shaped chest	http://purl.obolibrary.org/obo/HP_0001591		hposlim_core
HP:0025540	biolink:PhenotypicFeature	Abnormal T cell subset distribution	Any abnormality in the proportion T cells subsets relative to the total number of T cells.		hp.json		http://purl.obolibrary.org/obo/HP_0025540		
HP:0003909	biolink:PhenotypicFeature	Cortical subperiosteal resorption of humeral metaphyses		UMLS:C4025515	hp.json		http://purl.obolibrary.org/obo/HP_0003909		
HP:0003904	biolink:PhenotypicFeature	Wide epiphyses of the upper limbs		UMLS:C4021709	hp.json	Broad epiphyses of the upper limbs|Wide end part of upper limb bones	http://purl.obolibrary.org/obo/HP_0003904		
HP:0003903	biolink:PhenotypicFeature	Broad humeral epiphyses	Increased width of the humeral epiphysis.	UMLS:C4021710	hp.json	Wide humeral epiphyses|Wide end part of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003903		
HP:0003902	biolink:PhenotypicFeature	Epiphyseal stippling of the humerus	The presence of abnormal punctate (speckled, dot-like) calcifications in the humeral epiphysis.	UMLS:C4021711	hp.json	Stippled ossification of the humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003902		
HP:0003901	biolink:PhenotypicFeature	Stippled calcification of the humeral epiphyses		UMLS:C4025519	hp.json		http://purl.obolibrary.org/obo/HP_0003901		
HP:0003908	biolink:PhenotypicFeature	Corner fracture of metaphysis	Fracture or fragmentation at the lateral portion of the metaphysis of a long bone. The radiographic appearance is that of a small corner of metaphysis separated from the metaphyseal edge by thin linear radiolucency. This feature can be observed in child abuse but fragmented appearance of the metaphysis or facture-like lesions can also be detected in the setting of certain skeletal dysplasias.	UMLS:C4025516	hp.json	Metaphyseal corner fracture|Bucket handle fracture	http://purl.obolibrary.org/obo/HP_0003908		
HP:0003907	biolink:PhenotypicFeature	Abnormal humeral metaphysis morphology		UMLS:C4025517	hp.json	Abnormality of the humeral metaphyses|Abnormality of the wide portion of the long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003907		
HP:0003906	biolink:PhenotypicFeature	Broad humeral epiphyseal plate	Increased width of the humeral epiphyseal growth plate.	UMLS:C4280540|UMLS:C4021708	hp.json	Wide humeral epiphyseal plate|Wide long bone of arm growth plate	http://purl.obolibrary.org/obo/HP_0003906		
HP:0003905	biolink:PhenotypicFeature	Abnormality of the humeral epiphyseal plate		UMLS:C4025518|UMLS:C4280541	hp.json	Abnormality of arm long bone growth plate	http://purl.obolibrary.org/obo/HP_0003905		
HP:0003900	biolink:PhenotypicFeature	Small humeral epiphyses		UMLS:C4025520	hp.json	Small end part of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003900		
HP:0003915	biolink:PhenotypicFeature	Lytic defects of the humeral metaphysis		UMLS:C4025512	hp.json		http://purl.obolibrary.org/obo/HP_0003915		
HP:0003914	biolink:PhenotypicFeature	Irregular ossification of humeral metaphyses		UMLS:C4025513	hp.json	Irregular bone maturation of the wide portion of the long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003914		
HP:0003913	biolink:PhenotypicFeature	Humeral metaphyseal irregularity		UMLS:C4021706	hp.json	Irregular wide portion of long bone in upper arm|Irregular humeral metaphyses	http://purl.obolibrary.org/obo/HP_0003913		
GO:1905383	biolink:BiologicalProcess	protein localization to presynapse	A process in which a protein is transported to, or maintained in, a location within a presynapse.		hp.json	recruitment of presynaptic proteins|protein localisation in presynapse|protein localisation to presynapse|protein localization in presynapse	http://purl.obolibrary.org/obo/GO_1905383		
HP:0003912	biolink:PhenotypicFeature	Frayed humeral metaphyses		UMLS:C4025514	hp.json		http://purl.obolibrary.org/obo/HP_0003912		
GO:1905384	biolink:BiologicalProcess	regulation of protein localization to presynapse	Any process that modulates the frequency, rate or extent of protein localization to presynapse.		hp.json	regulation of protein localisation in presynapse|regulation of protein localisation to presynapse|regulation of protein localization in presynapse|regulation of recruitment of presynaptic proteins	http://purl.obolibrary.org/obo/GO_1905384		
GO:1905385	biolink:BiologicalProcess	negative regulation of protein localization to presynapse	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to presynapse.		hp.json	inhibition of protein localisation to presynapse|downregulation of protein localization to presynapse|down-regulation of protein localisation to presynapse|downregulation of recruitment of presynaptic proteins|inhibition of recruitment of presynaptic proteins|negative regulation of protein localisation to presynapse|inhibition of protein localization in presynapse|down-regulation of protein localization in presynapse|negative regulation of protein localization in presynapse|downregulation of protein localisation in presynapse|down regulation of protein localization to presynapse|inhibition of protein localization to presynapse|down regulation of protein localisation in presynapse|down-regulation of protein localization to presynapse|negative regulation of recruitment of presynaptic proteins|down-regulation of recruitment of presynaptic proteins|inhibition of protein localisation in presynapse|downregulation of protein localisation to presynapse|negative regulation of protein localisation in presynapse|down-regulation of protein localisation in presynapse|downregulation of protein localization in presynapse|down regulation of recruitment of presynaptic proteins|down regulation of protein localisation to presynapse|down regulation of protein localization in presynapse	http://purl.obolibrary.org/obo/GO_1905385		
HP:0003919	biolink:PhenotypicFeature	Sclerotic humeral metaphysis with longitudinal striations		UMLS:C4025508	hp.json		http://purl.obolibrary.org/obo/HP_0003919		
GO:1905386	biolink:BiologicalProcess	positive regulation of protein localization to presynapse	Any process that activates or increases the frequency, rate or extent of protein localization to presynapse.		hp.json	up regulation of protein localisation in presynapse|up-regulation of protein localization to presynapse|up-regulation of recruitment of presynaptic proteins|upregulation of protein localisation to presynapse|upregulation of protein localization in presynapse|activation of protein localization to presynapse|up regulation of recruitment of presynaptic proteins|up-regulation of protein localisation in presynapse|activation of protein localisation in presynapse|positive regulation of protein localisation to presynapse|activation of recruitment of presynaptic proteins|positive regulation of protein localization in presynapse|positive regulation of recruitment of presynaptic proteins|up regulation of protein localisation to presynapse|up regulation of protein localization in presynapse|upregulation of protein localization to presynapse|upregulation of recruitment of presynaptic proteins|up-regulation of protein localisation to presynapse|up-regulation of protein localization in presynapse|upregulation of protein localisation in presynapse|activation of protein localisation to presynapse|activation of protein localization in presynapse|up regulation of protein localization to presynapse|positive regulation of protein localisation in presynapse	http://purl.obolibrary.org/obo/GO_1905386		
HP:0003918	biolink:PhenotypicFeature	Sclerotic humeral metaphysis		UMLS:C4025509	hp.json	Stiffening of wide portion of long bone of upper arm|Hardening of wide portion of long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003918		
HP:0003917	biolink:PhenotypicFeature	Pointed humeral metaphysis		UMLS:C4025510	hp.json	Pointed wide portion of long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003917		
HP:0003916	biolink:PhenotypicFeature	Normal-density transverse humeral bands		UMLS:C4025511	hp.json		http://purl.obolibrary.org/obo/HP_0003916		
HP:0003911	biolink:PhenotypicFeature	Flared humeral metaphysis	Flaring (increase of width with a splayed appearance) of the humeral metaphysis.	UMLS:C4020835|UMLS:C4020912	hp.json	Wide/broad humeral metaphysis|Flared wide portion of long bone of upper arm|Flared humerus	http://purl.obolibrary.org/obo/HP_0003911		
HP:0003910	biolink:PhenotypicFeature	Enlarged humeral metaphyses		UMLS:C4021707	hp.json	Expanded humeral metaphyses|Enlarged wide portion of long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003910		
HP:0003948	biolink:PhenotypicFeature	Irregular epiphyses of the elbow		UMLS:C4025486	hp.json	Irregular end part of the elbow bone	http://purl.obolibrary.org/obo/HP_0003948		
HP:0003947	biolink:PhenotypicFeature	Delayed elbow epiphyseal ossification	A delay in the process of formation and maturation of the epiphysis of one or more long bones that are part of the elbow.	UMLS:C4025487	hp.json	Delayed maturation of the end part of the elbow bone	http://purl.obolibrary.org/obo/HP_0003947		
HP:0003946	biolink:PhenotypicFeature	Abnormality of the epiphyses of the elbow		UMLS:C4025488	hp.json	Abnormality of end part of the elbow bone	http://purl.obolibrary.org/obo/HP_0003946		
HP:0003945	biolink:PhenotypicFeature	Irregular articular surfaces of the elbow joints		UMLS:C4025489	hp.json		http://purl.obolibrary.org/obo/HP_0003945		
HP:0003949	biolink:PhenotypicFeature	Abnormal elbow metaphysis morphology		UMLS:C4025485	hp.json	Abnormal wide portion of elbow bone	http://purl.obolibrary.org/obo/HP_0003949		
HP:0003940	biolink:PhenotypicFeature	Osteoarthritis of the elbow		SNOMEDCT_US:239866002|UMLS:C0409954	hp.json		http://purl.obolibrary.org/obo/HP_0003940		
HP:0003944	biolink:PhenotypicFeature	Narrow joint spaces of the elbow		UMLS:C4025490	hp.json	Narrow joint spaces of the elbow	http://purl.obolibrary.org/obo/HP_0003944		
HP:0003943	biolink:PhenotypicFeature	Abnormality of the joint spaces of the elbow		UMLS:C4025491	hp.json	Abnormality of the joint spaces of the elbow	http://purl.obolibrary.org/obo/HP_0003943		
HP:0003942	biolink:PhenotypicFeature	Synovial chondromatosis of the elbow		UMLS:C4025492	hp.json		http://purl.obolibrary.org/obo/HP_0003942		
HP:0003941	biolink:PhenotypicFeature	Stippled calcification of the elbow		UMLS:C4025493	hp.json		http://purl.obolibrary.org/obo/HP_0003941		
HP:0003959	biolink:PhenotypicFeature	Deformed forearm bones		UMLS:C4025479	hp.json	Deformed forearm bones	http://purl.obolibrary.org/obo/HP_0003959		
HP:0003958	biolink:PhenotypicFeature	Cross-fusion of the forearm bones		UMLS:C4025480	hp.json		http://purl.obolibrary.org/obo/HP_0003958		
HP:0003957	biolink:PhenotypicFeature	Cortical thickening of the forearm bones		UMLS:C4021842	hp.json		http://purl.obolibrary.org/obo/HP_0003957		
HP:0003956	biolink:PhenotypicFeature	Bowed forearm bones	A bending or abnormal curvature affecting either the radius, the ulna, or both.	UMLS:C4025481	hp.json	Bowed forearm bones	http://purl.obolibrary.org/obo/HP_0003956		
HP:0003951	biolink:PhenotypicFeature	Distal humeral metaphyseal irregularity	Irregularity of the normally smooth surface of the metaphysis at the distal end of the humerus (at the elbow).	UMLS:C4021703	hp.json	Irregular wide portion of elbow bone|Irregular metaphyses of elbow	http://purl.obolibrary.org/obo/HP_0003951		
HP:0003950	biolink:PhenotypicFeature	Flared elbow metaphyses		UMLS:C4025484	hp.json	Flared wide portion of elbow bone	http://purl.obolibrary.org/obo/HP_0003950		
HP:0003955	biolink:PhenotypicFeature	Bone-in-a-bone appearance of forearm	A descriptive term for a forearm bone that appears to have an additional bone within it on radiography.	UMLS:C4025482	hp.json	Bone-in-a-bone appearance of forearm	http://purl.obolibrary.org/obo/HP_0003955		
HP:0003954	biolink:PhenotypicFeature	Angulated forearm bones		UMLS:C4025483	hp.json	Angulated forearm bones	http://purl.obolibrary.org/obo/HP_0003954		
HP:0003953	biolink:PhenotypicFeature	Absent forearm bone	Absence of one or more forearm bones associated with congenital failure of development.	UMLS:C4021701	hp.json	Aplasia of the forearm bones|Absent forearm bone	http://purl.obolibrary.org/obo/HP_0003953		
HP:0003952	biolink:PhenotypicFeature	Sclerotic foci of metaphyses of the elbow		UMLS:C4021702	hp.json	Vertical linear mixed lucent and sclerotic pattern of metaphyses	http://purl.obolibrary.org/obo/HP_0003952		
HP:0003926	biolink:PhenotypicFeature	Abnormal humeral diaphysis morphology	An anomaly of the humeral diaphysis.	UMLS:C4025502	hp.json	Abnormality of the humeral diaphysis|Abnormality of shaft of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003926		
HP:0003924	biolink:PhenotypicFeature	Stippled calcification of humeral metaphysis		UMLS:C4025503	hp.json	Speckled calcification in metaphysis of long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003924		
HP:0003923	biolink:PhenotypicFeature	Square humeral metaphysis		UMLS:C4025504	hp.json	Square metaphysis of long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003923		
HP:0003929	biolink:PhenotypicFeature	Ground glass opacity of humeral diaphysis		UMLS:C4025499	hp.json		http://purl.obolibrary.org/obo/HP_0003929		
HP:0003928	biolink:PhenotypicFeature	Cortical thickening of humeral diaphysis		UMLS:C4025500	hp.json		http://purl.obolibrary.org/obo/HP_0003928		
HP:0003927	biolink:PhenotypicFeature	Cortical irregularity of humeral diaphysis	An abnormal irregularity of the cortical surface of the diaphysis (shaft) of the humerus.	UMLS:C4025501	hp.json		http://purl.obolibrary.org/obo/HP_0003927		
HP:0003922	biolink:PhenotypicFeature	Spurred humeral metaphysis		UMLS:C4025505	hp.json	Spurred metaphysis of long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003922		
HP:0003921	biolink:PhenotypicFeature	Laterally sloping humeral metaphysis		UMLS:C4025506	hp.json	Laterally sloping metaphysis of long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003921		
HP:0003920	biolink:PhenotypicFeature	Sloping humeral metaphysis		UMLS:C4025507	hp.json	Sloping metaphysis of long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003920		
HP:0003935	biolink:PhenotypicFeature	Wide humeral diaphysis	Increased width of the humeral diaphysis.	UMLS:C4021704	hp.json	Broad humeral diaphysis|Wide shaft of long bone in upper arm|Broad shaft of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003935		
HP:0003934	biolink:PhenotypicFeature	Slender humeral diaphysis		UMLS:C4025495	hp.json	Slender shaft of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003934		
HP:0003939	biolink:PhenotypicFeature	Humeroulnar synostosis	An abnormal osseous union (fusion) between the ulna and the humerus.	SNOMEDCT_US:205330003|UMLS:C0431799	hp.json	Humeral ulnar synostosis	http://purl.obolibrary.org/obo/HP_0003939		
HP:0003938	biolink:PhenotypicFeature	Synostosis involving the elbow		UMLS:C4025494	hp.json	Bone fusion involving the elbow	http://purl.obolibrary.org/obo/HP_0003938		
HP:0003933	biolink:PhenotypicFeature	Sclerosis of humeral diaphysis		UMLS:C4025496	hp.json	Increased bone density in shaft of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003933		
HP:0003932	biolink:PhenotypicFeature	Sclerotic foci of humeral diaphysis		UMLS:C4025497	hp.json		http://purl.obolibrary.org/obo/HP_0003932		
HP:0003931	biolink:PhenotypicFeature	Periosteal new bone of humeral diaphysis		UMLS:C4025498	hp.json		http://purl.obolibrary.org/obo/HP_0003931		
HP:0003930	biolink:PhenotypicFeature	Lytic defects of humeral diaphysis		UMLS:C4021705	hp.json	Humeral diaphyseal lysis	http://purl.obolibrary.org/obo/HP_0003930		
GO:0090594	biolink:BiologicalProcess	inflammatory response to wounding	The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents.		hp.json		http://purl.obolibrary.org/obo/GO_0090594		
GO:0090596	biolink:BiologicalProcess	sensory organ morphogenesis	Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.		hp.json		http://purl.obolibrary.org/obo/GO_0090596		
UBERON:0008585	biolink:AnatomicalEntity	levator veli palatini	The levator veli palatini is the elevator muscle of the velum palatinum in the human body. During swallowing, it contracts, elevating the soft palate to help prevent food from entering the nasopharynx. It is innervated via the pharyngeal plexus, primarily by the vagus nerve (CN X). The levator veli palatini (Levator palati) is a thick, rounded muscle situated lateral to the choanC&. It arises from the under surface of the apex of the petrous part of the temporal bone and from the medial lamina of the cartilage of the auditory tube. After passing above the upper concave margin of the Constrictor pharyngis superior it spreads out in the palatine velum, its fibers extending obliquely downward and medially to the middle line, where they blend with those of the opposite side.	FMA:46727	hp.json	levator veli|levator palati|levator veli palatini muscle|levator velum palatini muscle|musculus levator veli palatini	http://purl.obolibrary.org/obo/UBERON_0008585		
UBERON:0008588	biolink:AnatomicalEntity	procerus	The Procerus is a small pyramidal slip of muscle deep to the superior orbital nerve, artery and vein.	FMA:46769	hp.json	pyramidalis nasi|pyramidalis nasi|procerus muscle|depressor glabellae|depressor glabellae|musculus procerus glabellae	http://purl.obolibrary.org/obo/UBERON_0008588		
GO:1905300	biolink:BiologicalProcess	positive regulation of intestinal epithelial cell development	Any process that activates or increases the frequency, rate or extent of intestinal epithelial cell development.		hp.json	up regulation of intestinal epithelial cell development|up-regulation of intestinal epithelial cell development|activation of intestinal epithelial cell development|upregulation of intestinal epithelial cell development	http://purl.obolibrary.org/obo/GO_1905300		
UBERON:0008571	biolink:AnatomicalEntity	suprahyoid muscle	A muscle in the region above the hyoid bone in the neck. The suprahyoid muscles include digastric, stylohyoid, geniohyoid, and mylohyoid.	FMA:46290	hp.json	suprahyoid|musculi suprahyoidei|suprahyoidala	http://purl.obolibrary.org/obo/UBERON_0008571		
UBERON:0008572	biolink:AnatomicalEntity	posterior crico-arytenoid	The posterior cricoarytenoid muscles are extremely small, paired muscles that extend from the posterior cricoid cartilage to the arytenoid cartilages in the larynx. By rotating the arytenoid cartilages laterally, these muscles abduct the vocal cords and thereby open the rima glottidis. Their action opposes the lateral cricoarytenoid muscles. The posterior cricoarytenoid muscles receive innervation from the recurrent laryngeal branch of the vagus nerve (CN X). Paralysis of the posterior cricoarytenoid muscles may lead to asphyxiation as they are the only laryngeal muscles to open the true vocal folds, allowing inspiration and expiration.	FMA:46576	hp.json	cricoarytaenoideus posterior|posterior cricoarytenoideus|posterior cricoarytenoid|posterior cricoarytenoid muscle|musculus cricoarytenoideus posterior|cricoarytænoideus posterior	http://purl.obolibrary.org/obo/UBERON_0008572		
UBERON:0008573	biolink:AnatomicalEntity	lateral crico-arytenoid	The lateral cricoarytenoid (also anterior cricoarytenoid) muscles extend from the lateral cricoid cartilage to the ipsilateral arytenoid cartilage. By rotating the arytenoid cartilages medially, these muscles adduct the vocal cords and thereby close the rima glottidis, protecting the airway. (Their action is antagonistic to that of the posterior cricoarytenoid muscles. ) The lateral cricoarytenoid muscles receive innervation from the recurrent laryngeal branch of the vagus nerve (CN X).	FMA:46579	hp.json	cricoarytaenoideus lateralis muscle|lateral cricoarytenoid muscle|cricoarytænoideus lateralis muscle|musculus cricoarytenoideus lateralis|lateral cricoarytenoideus|lateral cricoarytenoid|cricoarytænoideus lateralis|cricoarytaenoideus lateralis	http://purl.obolibrary.org/obo/UBERON_0008573		
GO:1905310	biolink:BiologicalProcess	regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	Any process that modulates the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_1905310		
GO:1905311	biolink:BiologicalProcess	negative regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.		hp.json	inhibition of cardiac neural crest cell migration involved in outflow tract morphogenesis|downregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|down regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	http://purl.obolibrary.org/obo/GO_1905311		
GO:1905304	biolink:BiologicalProcess	regulation of cardiac myofibril assembly	Any process that modulates the frequency, rate or extent of cardiac myofibril assembly.		hp.json	regulation of heart myofibril assembly|regulation of cardiac myofibril morphogenesis|regulation of cardiac myofibril development	http://purl.obolibrary.org/obo/GO_1905304		
GO:1905305	biolink:BiologicalProcess	negative regulation of cardiac myofibril assembly	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac myofibril assembly.		hp.json	down regulation of cardiac myofibril morphogenesis|down regulation of cardiac myofibril assembly|down regulation of heart myofibril assembly|inhibition of cardiac myofibril assembly|down-regulation of cardiac myofibril development|negative regulation of cardiac myofibril development|negative regulation of heart myofibril assembly|down-regulation of cardiac myofibril assembly|inhibition of cardiac myofibril morphogenesis|downregulation of cardiac myofibril morphogenesis|down-regulation of heart myofibril assembly|down regulation of cardiac myofibril development|inhibition of heart myofibril assembly|downregulation of cardiac myofibril development|inhibition of cardiac myofibril development|negative regulation of cardiac myofibril morphogenesis|downregulation of cardiac myofibril assembly|downregulation of heart myofibril assembly|down-regulation of cardiac myofibril morphogenesis	http://purl.obolibrary.org/obo/GO_1905305		
GO:1905306	biolink:BiologicalProcess	positive regulation of cardiac myofibril assembly	Any process that activates or increases the frequency, rate or extent of cardiac myofibril assembly.		hp.json	activation of cardiac myofibril assembly|up regulation of cardiac myofibril development|upregulation of cardiac myofibril morphogenesis|up-regulation of cardiac myofibril assembly|activation of cardiac myofibril development|positive regulation of cardiac myofibril development|activation of heart myofibril assembly|upregulation of cardiac myofibril development|upregulation of heart myofibril assembly|up-regulation of cardiac myofibril morphogenesis|upregulation of cardiac myofibril assembly|up regulation of cardiac myofibril morphogenesis|positive regulation of heart myofibril assembly|activation of cardiac myofibril morphogenesis|up regulation of heart myofibril assembly|positive regulation of cardiac myofibril morphogenesis|up regulation of cardiac myofibril assembly|up-regulation of cardiac myofibril development|up-regulation of heart myofibril assembly	http://purl.obolibrary.org/obo/GO_1905306		
CHEBI:16113	biolink:ChemicalSubstance	cholesterol	A cholestanoid consisting of cholestane having a double bond at the 5,6-position as well as a 3beta-hydroxy group.	CAS:57-88-5|PMID:4696527|PMID:25522988|PMID:8838010|DrugBank:DB04540|PMID:16341241|PMID:24287311|PMID:25977713|CAS:57-88-5|KEGG:C00187|CAS:57-88-5|MetaCyc:CHOLESTEROL|PMID:25451949|Wikipedia:Cholesterol|LIPID_MAPS_instance:LMST01010001|PMID:11412894|KNApSAcK:C00003648|KEGG:D00040|Gmelin:550297|PMID:25658343|PMID:25308664|HMDB:HMDB0000067|PMID:10901445|Beilstein:2060565|PDBeChem:CLR|Reaxys:2060565	hp.json	cholest-5-en-3beta-ol|Cholesterol|(3beta,14beta,17alpha)-cholest-5-en-3-ol|CHOLESTEROL|cholesterol|Cholest-5-en-3beta-ol|Cholesterin	http://purl.obolibrary.org/obo/CHEBI_16113		3_STAR
GO:1905320	biolink:BiologicalProcess	regulation of mesenchymal stem cell migration	Any process that modulates the frequency, rate or extent of mesenchymal stem cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_1905320		
GO:1905321	biolink:BiologicalProcess	negative regulation of mesenchymal stem cell migration	Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal stem cell migration.		hp.json	down-regulation of mesenchymal stem cell migration|down regulation of mesenchymal stem cell migration|inhibition of mesenchymal stem cell migration|downregulation of mesenchymal stem cell migration	http://purl.obolibrary.org/obo/GO_1905321		
GO:1905322	biolink:BiologicalProcess	positive regulation of mesenchymal stem cell migration	Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration.		hp.json	upregulation of mesenchymal stem cell migration|up-regulation of mesenchymal stem cell migration|up regulation of mesenchymal stem cell migration|activation of mesenchymal stem cell migration	http://purl.obolibrary.org/obo/GO_1905322		
PR:000027222	biolink:Protein	CALCA gene translation product	A protein that is a translation product of the human CALCA gene or a 1:1 ortholog thereof.		hp.json	CALCA|CALC	http://purl.obolibrary.org/obo/PR_000027222		
GO:1905312	biolink:BiologicalProcess	positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	Any process that activates or increases the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.		hp.json	up-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|up regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|activation of cardiac neural crest cell migration involved in outflow tract morphogenesis|upregulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	http://purl.obolibrary.org/obo/GO_1905312		
GO:1905315	biolink:BiologicalProcess	cell proliferation involved in endocardial cushion morphogenesis	Any cell proliferation that is involved in endocardial cushion morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_1905315		
GO:1905319	biolink:BiologicalProcess	mesenchymal stem cell migration	The orderly movement of a mesenchymal stem cell from one site to another.		hp.json		http://purl.obolibrary.org/obo/GO_1905319		
GO:1905330	biolink:BiologicalProcess	regulation of morphogenesis of an epithelium	Any process that modulates the frequency, rate or extent of morphogenesis of an epithelium.		hp.json	regulation of epithelium morphogenesis	http://purl.obolibrary.org/obo/GO_1905330		
GO:1905331	biolink:BiologicalProcess	negative regulation of morphogenesis of an epithelium	Any process that stops, prevents or reduces the frequency, rate or extent of morphogenesis of an epithelium.		hp.json	down-regulation of morphogenesis of an epithelium|downregulation of epithelium morphogenesis|down regulation of epithelium morphogenesis|inhibition of epithelium morphogenesis|negative regulation of epithelium morphogenesis|down-regulation of epithelium morphogenesis|downregulation of morphogenesis of an epithelium|down regulation of morphogenesis of an epithelium|inhibition of morphogenesis of an epithelium	http://purl.obolibrary.org/obo/GO_1905331		
GO:1905332	biolink:BiologicalProcess	positive regulation of morphogenesis of an epithelium	Any process that activates or increases the frequency, rate or extent of morphogenesis of an epithelium.		hp.json	upregulation of morphogenesis of an epithelium|up-regulation of epithelium morphogenesis|activation of epithelium morphogenesis|up regulation of morphogenesis of an epithelium|upregulation of epithelium morphogenesis|up-regulation of morphogenesis of an epithelium|activation of morphogenesis of an epithelium|positive regulation of epithelium morphogenesis|up regulation of epithelium morphogenesis	http://purl.obolibrary.org/obo/GO_1905332		
GO:1905349	biolink:BiologicalProcess	ciliary transition zone assembly	The aggregation, arrangement and bonding together of a set of components to form a ciliary transition zone.		hp.json	ciliary transition zone formation|cilial transition zone formation|cilium transition zone assembly|cilium transition zone formation|cilial transition zone assembly	http://purl.obolibrary.org/obo/GO_1905349		
UBERON:0008593	biolink:AnatomicalEntity	zygomaticus major muscle	Facial muscle attached to the modiolus, corner (angle) of the mouth, and zygomatic bone. See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980.	NCIT:C53183|FMA:46810|UMLS:C0224115|MFMO:0000138	hp.json	auriculolabialis superior|zygomatic major|zygomaticus major|zygomaticcus major|zygomatic major muscle|musculus zygomaticus major|zygomatic muscle	http://purl.obolibrary.org/obo/UBERON_0008593		feed_aligned
UBERON:0008594	biolink:AnatomicalEntity	zygomaticus minor muscle	Facial muscle attached to the modiolus, corner (angle) of the mouth, and zygomatic bone. This muscle is ventral to the zygomaticus minor and dorsal to the platysma muscle. In many mammals this muscle also has an attachment to the cartilage of the external ear, in which case it is called the auriculolabialis inferior. See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980.	MFMO:0000137|FMA:46811|NCIT:C53184|UMLS:C0224116	hp.json	auriculolabialis superior|square muscle of the upper lip, zygomatic head|auriculolabialis superior|musculus quadratus labii superioris, zygomatic head|musculus zygomaticus minor	http://purl.obolibrary.org/obo/UBERON_0008594		feed_aligned
UBERON:0008595	biolink:AnatomicalEntity	levator anguli oris	The levator anguli oris (caninus) is a facial muscle of the mouth arising from the canine fossa, immediately below the infraorbital foramen. Its fibers are inserted into the angle of the mouth, intermingling with those of the Zygomaticus, Triangularis, and Orbicularis oris.	FMA:46822	hp.json	levator anguli oris|musculus levator anguli oris|caninus|levator anguli oris muscle|caninus muscle	http://purl.obolibrary.org/obo/UBERON_0008595		
UBERON:0008596	biolink:AnatomicalEntity	mentalis muscle	A muscle of facial expression, innervated by the facial nerve, attached to the skin of the lower lip and inferior to the lower lip (in humans this region is called the chin or mental region), the orbicularis oris muscle, and the mandible in the symphyseal region. See Diogo et al., 2009; Burrows et al., 2011).	MFMO:0000122|FMA:46825	hp.json	musculus mentalis|mentalis	http://purl.obolibrary.org/obo/UBERON_0008596		
UBERON:0008597	biolink:AnatomicalEntity	depressor anguli oris muscle	The Depressor anguli oris (Triangularis) arises from the oblique line of the mandible, whence its fibers converge, to be inserted, by a narrow fasciculus, into the angle of the mouth.	FMA:46828|EMAPA:37842	hp.json	musculus depressor anguli oris|triangularis|triangularis muscle|depressor anguli oris	http://purl.obolibrary.org/obo/UBERON_0008597		
UBERON:0008598	biolink:AnatomicalEntity	risorius muscle	Facial muscle that attaches to the fascia of the masseter muscle and the facia of the skin in the region of the corner (angle) of the mouth. Even in species in which this muscle is present, it is highly variable. A true risorius muscle may only be present in Hominins (humans and great apes). See Diogo 2008; Diogo et al., 2009; Burrows et al.., 2011., also DuBrul, 1980.	MFMO:0000141|FMA:46838	hp.json	musculus risorius|risorius	http://purl.obolibrary.org/obo/UBERON_0008598		feed_aligned
CHEBI:28044	biolink:ChemicalSubstance	phenylalanine	An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	CAS:150-30-1|Wikipedia:Phenylalanine|PMID:22264337|KEGG:C02057|PMID:17439666|Beilstein:1910407|CAS:150-30-1|Reaxys:1910407|Gmelin:50836	hp.json	Phenylalanin|Phenylalanine|2-amino-3-phenylpropanoic acid|PHE|phenylalanine|alpha-Amino-beta-phenylpropionic acid|phenylalanine|DL-Phenylalanine|F|fenilalanina	http://purl.obolibrary.org/obo/CHEBI_28044		3_STAR
HP:0001288	biolink:PhenotypicFeature	Gait disturbance	The term gait disturbance can refer to any disruption of the ability to walk. In general, this can refer to neurological diseases but also fractures or other sources of pain that is triggered upon walking. However, in the current context gait disturbance refers to difficulty walking on the basis of a neurological or muscular disease.	SNOMEDCT_US:22325002|UMLS:C0575081	hp.json	Impaired gait|Abnormal walk|Gait abnormalities|Gait difficulties|Abnormal gait|Gait disturbances	http://purl.obolibrary.org/obo/HP_0001288		
CHEBI:28050	biolink:ChemicalSubstance	homocarnosine	A histidine derivative that is histidine in which one of the hydrogens attached to the alpha-amino group has been replaced by a 4-aminobutanoyl group.	Reaxys:11612459	hp.json	N-(4-aminobutanoyl)histidine|N-(4-aminobutyryl)histidine|gamma-Aminobutyryl histidine	http://purl.obolibrary.org/obo/CHEBI_28050		3_STAR
HP:0025255	biolink:PhenotypicFeature	Ameliorated by pregnancy	Applies to a sign or symptom that is improved or made more bearable by pregnancy in a female.		hp.json	Pregnancy relieves symptoms	http://purl.obolibrary.org/obo/HP_0025255		
HP:0001289	biolink:PhenotypicFeature	Confusion	Lack of clarity and coherence of thought, perception, understanding, or action.	MSH:D003221|SNOMEDCT_US:286933003|UMLS:C0009676	hp.json	Mental disorientation|Confusion|Easily confused|Disorientation	http://purl.obolibrary.org/obo/HP_0001289		
HP:0025256	biolink:PhenotypicFeature	Ameliorated by heat	Applies to a sign or symptom that is improved or made more bearable by heat (including fever).		hp.json	Fever improves condition|Heat improves condition|Heat improves symptom	http://purl.obolibrary.org/obo/HP_0025256		
HP:0025257	biolink:PhenotypicFeature	Ameliorated by carbohydrate ingestion	Applies to a sign or symptom that is improved or made more bearable by eating or drinking carbohydrates including glucose (sugar).		hp.json		http://purl.obolibrary.org/obo/HP_0025257		
HP:0001287	biolink:PhenotypicFeature	Meningitis	Inflammation of the meninges.	UMLS:C0025289|MSH:D008581|SNOMEDCT_US:7180009	hp.json		http://purl.obolibrary.org/obo/HP_0001287		
HP:0025258	biolink:PhenotypicFeature	Stiff neck	A sensation of tightness in the neck when attempting to move it, especially after a period of inactivity. Neck stiffness often involves soreness and difficulty moving the neck, especially when trying to turn the head to the side.		hp.json	Stiff neck|Neck stiffness	http://purl.obolibrary.org/obo/HP_0025258		
HP:0025259	biolink:PhenotypicFeature	Stiff elbow	A sensation of tightness in the elbow joint when attempting to move it, especially after a period of inactivity.		hp.json	Elbow stiffness|Stiff elbow	http://purl.obolibrary.org/obo/HP_0025259		
HP:0001281	biolink:PhenotypicFeature	Tetany	A condition characterized by intermittent involuntary contraction of muscles (spasms) related to hypocalcemia or occasionally magnesium deficiency.	UMLS:C0039621|MSH:D013746|SNOMEDCT_US:10629009	hp.json	Intermittent involuntary muscle spasm	http://purl.obolibrary.org/obo/HP_0001281		
HP:0025250	biolink:PhenotypicFeature	Closed comedo	A comedo in which the top of the pore is not stretched open and thus does not expose the clogged portion (which would appear black), hence the name whitehead.		hp.json	Whitehead	http://purl.obolibrary.org/obo/HP_0025250		
HP:0025251	biolink:PhenotypicFeature	Open comedo	A comedo in which the part of the pore at the surface of the skin is stretched and open, exposing the contents of the comedo, which appear black.		hp.json	Blackhead	http://purl.obolibrary.org/obo/HP_0025251		
HP:0001284	biolink:PhenotypicFeature	Areflexia	Absence of neurologic reflexes such as the knee-jerk reaction.	UMLS:C0241772|MSH:D012021|UMLS:C0234146|UMLS:C0278124|SNOMEDCT_US:37280007|SNOMEDCT_US:349006	hp.json	Absent reflexes|Loss of deep tendon reflexes|Deep tendon reflexes absent|Absent deep tendon reflexes|Absent tendon reflexes	http://purl.obolibrary.org/obo/HP_0001284		
HP:0025252	biolink:PhenotypicFeature	Geographic tongue	An anomaly of the tongue characterized by loss (atrophy) of filiform papillae of the tongue, leaving areas of erythema (redness), surrounded by a serpiginous, white, hyperkeratotic border. The name geographic tongue refers to an appearance that is said to be similar to a map.		hp.json	Wandering rash of the tongue|Annulus migrans|Glossitis areata exfoliativa|Benign migratory glossitis|Lingual erythema migrans	http://purl.obolibrary.org/obo/HP_0025252		
HP:0001285	biolink:PhenotypicFeature	Spastic tetraparesis	Spastic weakness affecting all four limbs.	UMLS:C0575059|SNOMEDCT_US:298282001	hp.json	Spastic quadriparesis	http://purl.obolibrary.org/obo/HP_0001285		
HP:0025253	biolink:PhenotypicFeature	Claustrophobia	An abnormal fear of being in a closed or narrow space with no escape.		hp.json		http://purl.obolibrary.org/obo/HP_0025253		
CHEBI:53000	biolink:ChemicalSubstance	epitope	The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.		hp.json	epitope function|epitope role|antigenic determinant	http://purl.obolibrary.org/obo/CHEBI_53000		3_STAR
HP:0025254	biolink:PhenotypicFeature	Ameliorated by	An ameliorating factor is defined as an external factor that leads to a sign or symptom that is already present improving or becoming more bearable		hp.json	Improved by	http://purl.obolibrary.org/obo/HP_0025254		
HP:0001283	biolink:PhenotypicFeature	Bulbar palsy	Bulbar weakness (or bulbar palsy) refers to bilateral impairment of function of the lower cranial nerves IX, X, XI and XII, which occurs due to lower motor neuron lesion either at nuclear or fascicular level in the medulla or from bilateral lesions of the lower cranial nerves outside the brain-stem. Bulbar weakness is often associated with difficulty in chewing, weakness of the facial muscles, dysarthria, palatal weakness and regurgitation of fluids, dysphagia, and dysphonia.	UMLS:C4082299|UMLS:C1301959|SNOMEDCT_US:398432008|MSH:D010244	hp.json	Bulbar palsies|Bulbar muscle weakness|Bulbar weakness	http://purl.obolibrary.org/obo/HP_0001283		
HP:0025244	biolink:PhenotypicFeature	Subretinal pigment epithelium hemorrhage	An accumulation of blood located between the retinal pigment epithelium (RPE) and Bruch's membrane.		hp.json	Subretinal pigment epithelium haemorrhage	http://purl.obolibrary.org/obo/HP_0025244		
HP:0025245	biolink:PhenotypicFeature	Cutaneous cyst	A hollow mass located in the skin that is surrounded by an epithelium-lined wall and is well demarcated from the adjacent tissue. Cysts are often said to be sac-like and may contain serous liquid or semisolid material.		hp.json		http://purl.obolibrary.org/obo/HP_0025245		
HP:0001297	biolink:PhenotypicFeature	Stroke	Sudden impairment of blood flow to a part of the brain due to occlusion or rupture of an artery to the brain.	UMLS:C0038454|SNOMEDCT_US:230690007|MSH:D020521	hp.json	Cerebrovascular accidents|Cerebral vascular events|Cerebrovascular accident|Stroke	http://purl.obolibrary.org/obo/HP_0001297		
GO:2000351	biolink:BiologicalProcess	regulation of endothelial cell apoptotic process	Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process.		hp.json	regulation of endothelial cell programmed cell death by apoptosis|regulation of programmed cell death of endothelial cells by apoptosis|regulation of programmed cell death, endothelial cells|regulation of endothelial cell apoptosis|regulation of apoptosis of endothelial cells|regulation of killing of endothelial cells	http://purl.obolibrary.org/obo/GO_2000351		
HP:0025246	biolink:PhenotypicFeature	Trichilemmal cyst	Nontender, round and firm, but slightly compressible, intradermal or subcutaneous cyst measuring 0.5-5 cm in diameter. Trichilemmal cysts are acquired rather than congenital, and tend to appear on the scalp rather than the face, and to be intradermal rather than subcutaneous.		hp.json	Pilar cyst	http://purl.obolibrary.org/obo/HP_0025246		
OBO:uberon/core#subdivision_of	biolink:NamedThing	subdivision of			hp.json		http://purl.obolibrary.org/obo/uberon/core#subdivision_of		
HP:0001298	biolink:PhenotypicFeature	Encephalopathy	Encephalopathy is a term that means brain disease, damage, or malfunction. In general, encephalopathy is manifested by an altered mental state.	MSH:D001927|SNOMEDCT_US:81308009|UMLS:C0085584	hp.json		http://purl.obolibrary.org/obo/HP_0001298		
GO:2000352	biolink:BiologicalProcess	negative regulation of endothelial cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.		hp.json	negative regulation of programmed cell death of endothelial cells by apoptosis|negative regulation of apoptosis of endothelial cells|negative regulation of killing of endothelial cells|negative regulation of programmed cell death, endothelial cells|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell programmed cell death by apoptosis	http://purl.obolibrary.org/obo/GO_2000352		
HP:0025247	biolink:PhenotypicFeature	Dermoid cyst	A congenital subcutaneous cyst that arises from entrapment of skin along the lines of embryonic fusion. In contrast to epidermal cysts, dermoid cysts tend to contain various adnexal structures such as hair, sebaceous, eccrine or apocrine glands. Dermoid cysts are present at birth, and are indolent, firm, deep, subcutaneous nodules. They are often located on the head and neck, and rarely in the anogenital area. Dermoid cysts are slowly progressive and can grow to a size of 1 to 4 cm.		hp.json		http://purl.obolibrary.org/obo/HP_0025247		
HP:0025248	biolink:PhenotypicFeature	Eruptive vellus hair cyst	A cutaneous cyst that is small (one or two millimeters in diameter) and painless, presenting as a follicular papule that usually is skin colored but may have a reddish or brownish tinge.		hp.json		http://purl.obolibrary.org/obo/HP_0025248		
GO:2000353	biolink:BiologicalProcess	positive regulation of endothelial cell apoptotic process	Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.		hp.json	positive regulation of endothelial cell apoptosis|positive regulation of apoptosis of endothelial cells|positive regulation of endothelial cell programmed cell death by apoptosis|positive regulation of killing of endothelial cells|positive regulation of programmed cell death of endothelial cells by apoptosis|positive regulation of programmed cell death, endothelial cells	http://purl.obolibrary.org/obo/GO_2000353		
HP:0025249	biolink:PhenotypicFeature	Comedo	A clogged cutaneous sebaceous follicle, which is a cutaneous gland that secretes sebum (usually into a hair follicle).		hp.json		http://purl.obolibrary.org/obo/HP_0025249		
HP:0001291	biolink:PhenotypicFeature	Abnormal cranial nerve morphology	Structural abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem.	UMLS:C1854510|UMLS:C4020872	hp.json	Cranial nerve abnormality|Abnormality of cranial nerve|Abnormality of the cranial nerves|Cranial nerve disease|Cranial nerve involvement	http://purl.obolibrary.org/obo/HP_0001291		
HP:0001290	biolink:PhenotypicFeature	Generalized hypotonia	Generalized muscular hypotonia (abnormally low muscle tone).	UMLS:C1858120	hp.json	Hypotonia, generalized|Generalised decreased muscle tone|Generalized decreased muscle tone|Generalized muscular hypotonia|Hypotonia, generalised|Generalised hypotonia|Generalised muscular hypotonia	http://purl.obolibrary.org/obo/HP_0001290		
HP:0025240	biolink:PhenotypicFeature	Preretinal hemorrhage	An accumulation of blood between the neurosensory retina and the retinal pigment epithelium (RPE) arising from the choroidal or retinal circulation.		hp.json	Preretinal heme|Preretinal haemorrhage	http://purl.obolibrary.org/obo/HP_0025240		
HP:0025241	biolink:PhenotypicFeature	Flame-shaped retinal hemorrhage	A type of retinal hemorrhage that is located within the nerve fiber layer (NFL) of the retina and that exhibits a characteristic flame shape which results from constraints by the structure of the NFL (axons of the ganglion cells).		hp.json	Flame-shaped retinal haemorrhage|Feathered retinal heme|Linear retina heme	http://purl.obolibrary.org/obo/HP_0025241		
HP:0025242	biolink:PhenotypicFeature	Dot-and-blot retinal hemorrhage	Accumulation of blood located in the retina's inner nuclear and outer plexiform layers, and having a dot-like or blot-like shape. THe shape results from intraretinal compression, restricting the hemorrhages within a specific location.		hp.json	Round retinal heme|Dot-and-blot retinal haemorrhage	http://purl.obolibrary.org/obo/HP_0025242		
HP:0001293	biolink:PhenotypicFeature	Cranial nerve compression		SNOMEDCT_US:95664006|UMLS:C0521670	hp.json		http://purl.obolibrary.org/obo/HP_0001293		
CHEBI:16042	biolink:ChemicalSubstance	halide anion	A monoatomic monoanion resulting from the addition of an electron to any halogen atom.	KEGG:C00462	hp.json	a halide anion|halide anions|halogen anion|Halide|halides|halide(1-)|HX|halide ions	http://purl.obolibrary.org/obo/CHEBI_16042		3_STAR
HP:0025243	biolink:PhenotypicFeature	Subretinal hemorrhage	Accumulation of blood located beneath the neurosensory retina in the space between the neurosensory retina and the retinal pigment epithelium.		hp.json	Subretinal haemorrhage|Subretinal heme	http://purl.obolibrary.org/obo/HP_0025243		
CHEBI:16080	biolink:ChemicalSubstance	gamma-amino-beta-hydroxybutyric acid	A gamma-amino acid comprising 4-aminobutyric acid having a 2-hydroxy substituent.	Drug_Central:1263|Beilstein:1752568|KEGG:D00174|CAS:352-21-6|CAS:352-21-6|KEGG:C03678|Beilstein:1721708	hp.json	4-Amino-3-hydroxybutanoic acid|4-amino-3-hydroxybutanoic acid|3-hydroxy-GABA|GABOB|gamma-Amino-beta-hydroxybutyric acid|4-amino-3-hydroxybutyric acid	http://purl.obolibrary.org/obo/CHEBI_16080		3_STAR
HP:0001266	biolink:PhenotypicFeature	Choreoathetosis	Involuntary movements characterized by both athetosis (inability to sustain muscles in a fixed position) and chorea (widespread jerky arrhythmic movements).	UMLS:C0234967|UMLS:C0085583|SNOMEDCT_US:43105007	hp.json	Choreoathetoid movements	http://purl.obolibrary.org/obo/HP_0001266		
HP:0025233	biolink:PhenotypicFeature	Sleep paralysis	An inability to move the body at sleep onset or upon awakening from sleep lasting seconds to a few minutes.		hp.json		http://purl.obolibrary.org/obo/HP_0025233		
HP:0025234	biolink:PhenotypicFeature	Parasomnia	An undesirable physical event or experience that occurs during entry into sleep, during sleep, or during arousal from sleep.		hp.json		http://purl.obolibrary.org/obo/HP_0025234		
HP:0025235	biolink:PhenotypicFeature	Non-rapid eye movement parasomnia	A parasomnia that occurs in non-rapid eye movement (NREM) sleep. This refers to a disorder of arousal that occurs during slow-wave sleep (ie, NREM stage 3 sleep).		hp.json	NREM parasomnia	http://purl.obolibrary.org/obo/HP_0025235		
HP:0001264	biolink:PhenotypicFeature	Spastic diplegia	Spasticity (neuromuscular hypertonia) primarily in the muscles of the legs, hips, and pelvis.	UMLS:C0023882|SNOMEDCT_US:281411007|MSH:D002547	hp.json	Spastic diplegic|Spastic diparesis	http://purl.obolibrary.org/obo/HP_0001264		
HP:0001265	biolink:PhenotypicFeature	Hyporeflexia	Reduction of neurologic reflexes such as the knee-jerk reaction.	SNOMEDCT_US:405946002|UMLS:C0700078	hp.json	Decreased reflex response|Decreased reflexes	http://purl.obolibrary.org/obo/HP_0001265		
HP:0025236	biolink:PhenotypicFeature	Somnambulism	Ambulation or other complex motor behaviors after getting out of bed in a sleep-like state. During sleepwalking episodes, the sonambulating individual appears confused or dazed, the eyes are usually open, and he or she might mumble or give inappropriate answers to questions, or occasionally appear agitated.		hp.json	Sleep walking	http://purl.obolibrary.org/obo/HP_0025236		
HP:0025237	biolink:PhenotypicFeature	Confusional arousal	A nocturnal episode characterized by disorientation, grogginess, and, at times, substantial agitation upon awakening from slow-wave sleep or following forced awakenings. These characteristics might present as agitation, crying or moaning, disorientation, and particularly slow mentation on arousal from sleep (i.e., sleep inertia). The duration of episodes is typically 5 to 15 min but they might last up to several hours.		hp.json		http://purl.obolibrary.org/obo/HP_0025237		
HP:0025238	biolink:PhenotypicFeature	Foot pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the foot.		hp.json	Foot pain	http://purl.obolibrary.org/obo/HP_0025238		
HP:0025239	biolink:PhenotypicFeature	Subhyaloid hemorrhage	A localized detachment of the vitreous from the retina due to the accumulation of blood. When localized in the macular area, it results in sudden profound loss of vision. Subhyaloid premacular hemorrhage is typically characterized by a circumscribed, round or dumb-bell shaped, bright red mound of blood beneath the internal limiting membrane (ILM) or between the ILM and hyaloid face, in or near to the central macular area.		hp.json	Subhyaloid haemorrhage|Subhyaloid heme	http://purl.obolibrary.org/obo/HP_0025239		
HP:0001268	biolink:PhenotypicFeature	Mental deterioration	Loss of previously present mental abilities, generally in adults.	MSH:D060825|UMLS:C0234985	hp.json	Progressive cognitive decline|Intellectual deterioration|Cognitive decline, progressive|Mental deterioration|Cognitive decline	http://purl.obolibrary.org/obo/HP_0001268		
HP:0001269	biolink:PhenotypicFeature	Hemiparesis	Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a complete loss of strength, whereas hemiparesis refers to an incomplete loss of strength.	SNOMEDCT_US:127377003|UMLS:C0018989|MSH:D010291|SNOMEDCT_US:20022000	hp.json	Weakness of one side of body	http://purl.obolibrary.org/obo/HP_0001269		
HP:0001262	biolink:PhenotypicFeature	Excessive daytime somnolence	A state of abnormally strong desire for sleep during the daytime.	SNOMEDCT_US:79519003|UMLS:C2830004|SNOMEDCT_US:271782001	hp.json	More than typical sleepiness during day|Excessive daytime sleepiness	http://purl.obolibrary.org/obo/HP_0001262		
HP:0001263	biolink:PhenotypicFeature	Global developmental delay	A delay in the achievement of motor or mental milestones in the domains of development of a child, including motor skills, speech and language, cognitive skills, and social and emotional skills. This term should only be used to describe children younger than five years of age.	UMLS:C1864897|UMLS:C0557874|UMLS:C4020875|SNOMEDCT_US:224958001	hp.json	Developmental delay, global|Delayed psychomotor development|Psychomotor development deficiency|Delayed development|Retarded psychomotor development|Retarded development|Delayed developmental milestones|Psychomotor developmental delay|Developmental retardation|Delayed intellectual development|Developmental delay|Cognitive delay|Delayed cognitive development|Developmental delay in early childhood|Lack of psychomotor development|Psychomotor development failure|Motor and developmental delay|Psychomotor delay|Mental and motor retardation|Retarded mental development|Motormental retardation|Delayed milestones	http://purl.obolibrary.org/obo/HP_0001263		
HP:0025230	biolink:PhenotypicFeature	Tendonitis	Inflammation of a tendon.		hp.json	Teninitis	http://purl.obolibrary.org/obo/HP_0025230		
HP:0001260	biolink:PhenotypicFeature	Dysarthria	Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.	MSH:D004401|SNOMEDCT_US:8011004|UMLS:C0013362	hp.json	Difficulty articulating speech|Dysarthric speech	http://purl.obolibrary.org/obo/HP_0001260		
HP:0025231	biolink:PhenotypicFeature	Abnormal synovial bursa morphology	A structural anomaly of a synovial bursa.		hp.json	Abnormality of synovial bursa morphology	http://purl.obolibrary.org/obo/HP_0025231		
HP:0025232	biolink:PhenotypicFeature	Bursitis	Inflammation of a synovial bursa.		hp.json		http://purl.obolibrary.org/obo/HP_0025232		
CHEBI:16070	biolink:ChemicalSubstance	1,5-anhydro-D-glucitol	An anhydro sugar of D-glucitol.	PMID:19796288|KEGG:C07326|PMID:18492944|CAS:154-58-5|HMDB:HMDB0002712|CAS:154-58-5|Wikipedia:1,5-Anhydroglucitol|PMID:15277408|Reaxys:80736|PDBeChem:ASO	hp.json	1,5-anhydroglucitol|1,5-anhydro-D-sorbitol|1,5-ANHYDROSORBITOL|1,5-anhydro-D-glucitol|1,5-anhydro-D-glucitol|(2R,3S,4R,5S)-2-(hydroxymethyl)oxane-3,4,5-triol|1,5-Anhydroglucitol|1,5-Anhydro-D-sorbitol|1,5-Anhydro-D-glucitol	http://purl.obolibrary.org/obo/CHEBI_16070		3_STAR
GO:2000379	biolink:BiologicalProcess	positive regulation of reactive oxygen species metabolic process	Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.		hp.json	positive regulation of reactive oxygen species metabolism|positive regulation of ROS metabolic process	http://purl.obolibrary.org/obo/GO_2000379		
CHEBI:65023	biolink:ChemicalSubstance	anti-asthmatic agent	Any compound that has anti-asthmatic effects.		hp.json	anti-asthmatic agents|antiasthmatic agents|antiasthmatic agent	http://purl.obolibrary.org/obo/CHEBI_65023		3_STAR
HP:0025222	biolink:PhenotypicFeature	Triggered by sleep deprivation	Applies to a sign or symptom that is provoked or brought about by a lack of sufficient sleep.		hp.json	Triggered by sleep deprivation|Sleep deprivation triggered symptoms	http://purl.obolibrary.org/obo/HP_0025222		
HP:0025223	biolink:PhenotypicFeature	Triggered by smoking	Applies to a sign or symptom that is provoked or brought about by smoking.		hp.json	Triggered by cigarette consumption|Triggered by smoking|Triggered by tobacco use|Smoking triggered symptoms	http://purl.obolibrary.org/obo/HP_0025223		
HP:0001278	biolink:PhenotypicFeature	Orthostatic hypotension	A form of hypotension characterized by a sudden fall in blood pressure that occurs when a person assumes a standing position.	SNOMEDCT_US:28651003|UMLS:C0020651|MSH:D007024	hp.json	Decrease in blood pressure upon standing up|Postural hypotension	http://purl.obolibrary.org/obo/HP_0001278		
HP:0025224	biolink:PhenotypicFeature	Triggered by sodium ingestion	Applies to a sign or symptom that is provoked or brought about by eating or drinking sodium.		hp.json	Triggered by sodium intake|Triggered by Na ingestion|Sodium ingestion triggered symptoms|Triggered by salt ingestion|Triggered by Na+ ingestion|Sodium intake triggered attacks	http://purl.obolibrary.org/obo/HP_0025224		
HP:0025225	biolink:PhenotypicFeature	Triggered by sound	Applies to a sign or symptom that is provoked or brought about by exposure to sound or noise.		hp.json	Sound triggered symptoms|Triggered by sound	http://purl.obolibrary.org/obo/HP_0025225		
HP:0001276	biolink:PhenotypicFeature	Hypertonia	A condition in which there is increased muscle tone so that arms or legs, for example, are stiff and difficult to move.	SNOMEDCT_US:41581000|MSH:D009122|SNOMEDCT_US:56731001|UMLS:C0026826	hp.json	Spasticity and rigidity of muscles|Hypertonicity|Muscle hypertonia|Increased muscle tone	http://purl.obolibrary.org/obo/HP_0001276		
GO:2000374	biolink:BiologicalProcess	regulation of oxygen metabolic process	Any process that modulates the frequency, rate or extent of oxygen metabolic process.		hp.json	regulation of oxygen metabolism|regulation of diatomic oxygen metabolic process	http://purl.obolibrary.org/obo/GO_2000374		
GO:2000375	biolink:BiologicalProcess	negative regulation of oxygen metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process.		hp.json	negative regulation of diatomic oxygen metabolic process|negative regulation of oxygen metabolism	http://purl.obolibrary.org/obo/GO_2000375		
HP:0025226	biolink:PhenotypicFeature	Triggered by stress	Applies to a sign or symptom that is provoked or brought about by a physical, mental, or emotional factor associated with bodily or mental tension.		hp.json	Stress triggered symptoms|Triggered by stress	http://purl.obolibrary.org/obo/HP_0025226		
GO:2000376	biolink:BiologicalProcess	positive regulation of oxygen metabolic process	Any process that activates or increases the frequency, rate or extent of oxygen metabolic process.		hp.json	positive regulation of diatomic oxygen metabolic process|positive regulation of oxygen metabolism	http://purl.obolibrary.org/obo/GO_2000376		
HP:0025227	biolink:PhenotypicFeature	Triggered by excitement	Applies to a sign or symptom that is provoked or brought about by a a state of excitement or by being startled.		hp.json	Triggered by excitement|Excitement triggered symptoms|Triggered by startle	http://purl.obolibrary.org/obo/HP_0025227		
HP:0025228	biolink:PhenotypicFeature	Triggered by sudden movement	Applies to a sign or symptom that is provoked or brought about by a sudden movement.		hp.json	Sudden movement triggered symptoms|Kinesigenic|Triggered by sudden movement	http://purl.obolibrary.org/obo/HP_0025228		
GO:2000377	biolink:BiologicalProcess	regulation of reactive oxygen species metabolic process	Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.		hp.json	regulation of reactive oxygen species metabolism|regulation of ROS metabolic process	http://purl.obolibrary.org/obo/GO_2000377		
HP:0001279	biolink:PhenotypicFeature	Syncope	Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow.	SNOMEDCT_US:272030005|SNOMEDCT_US:271594007|MSH:D013575|UMLS:C0039070|SNOMEDCT_US:309585006	hp.json	Fainting spell	http://purl.obolibrary.org/obo/HP_0001279		
HP:0025229	biolink:PhenotypicFeature	Triggered by vestibular stimulation	Applies to a sign or symptom that is provoked or brought about by vestibular stimulation, including head turning, cold calorics, postural changes, or rotating chair.		hp.json	Vestibular stimulation triggered attacks|Vestibular stimulation triggered symptoms	http://purl.obolibrary.org/obo/HP_0025229		
GO:2000378	biolink:BiologicalProcess	negative regulation of reactive oxygen species metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process.		hp.json	negative regulation of ROS metabolic process|negative regulation of reactive oxygen species metabolism	http://purl.obolibrary.org/obo/GO_2000378		
HP:0001270	biolink:PhenotypicFeature	Motor delay	A type of Developmental delay characterized by a delay in acquiring motor skills.	UMLS:C1854301|UMLS:C4020874	hp.json	Delayed motor milestones|Locomotor delay|Delayed early motor milestones|Motor retardation|Motor developmental milestones not achieved|Delayed motor development|Delay in motor development|Retarded motor development|No development of motor milestones|Motor developmental delay	http://purl.obolibrary.org/obo/HP_0001270		
HP:0001273	biolink:PhenotypicFeature	Abnormal corpus callosum morphology	Abnormality of the corpus callosum.	UMLS:C1842581	hp.json	Abnormal corpus callosum|Corpus callosum abnormality|Abnormality of the corpus callosum	http://purl.obolibrary.org/obo/HP_0001273		
HP:0001274	biolink:PhenotypicFeature	Agenesis of corpus callosum	Absence of the corpus callosum as a result of the failure of the corpus callosum to develop, which can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline.	Fyler:4321|UMLS:C0175754|SNOMEDCT_US:5102002|MSH:D061085	hp.json	Absence of corpus callosum|Absent corpus callosum|Callosal agenesis|Dysplastic or absent corpus callosum|Corpus callosum agenesis|Agenesis of the corpus callosum	http://purl.obolibrary.org/obo/HP_0001274		
HP:0025220	biolink:PhenotypicFeature	Triggered by menstruation	Applies to a sign or symptom that is provoked or brought about by menstruation in a female.		hp.json	Triggered by monthly period|Triggered by period|Menstruation triggered symptoms	http://purl.obolibrary.org/obo/HP_0025220		
HP:0001271	biolink:PhenotypicFeature	Polyneuropathy	A generalized disorder of peripheral nerves.	SNOMEDCT_US:42658009|MSH:D010523|UMLS:C0031117|MSH:D011115|SNOMEDCT_US:42345000|SNOMEDCT_US:302226006|UMLS:C0152025	hp.json	Peripheral nerve disease	http://purl.obolibrary.org/obo/HP_0001271		
HP:0001272	biolink:PhenotypicFeature	Cerebellar atrophy	Cerebellar atrophy is defined as a cerebellum with initially normal structures, in a posterior fossa with normal size, which displays enlarged fissures (interfolial spaces) in comparison to the foliae secondary to loss of tissue. Cerebellar atrophy implies irreversible loss of tissue and result from an ongoing progressive disease until a final stage is reached or a single injury, e.g. an intoxication or infectious event.	UMLS:C0740279|UMLS:C0262404|UMLS:C4020873|SNOMEDCT_US:95646004	hp.json	Atrophic cerebellum|Degeneration of cerebellum|Infratentorial atrophy	http://purl.obolibrary.org/obo/HP_0001272		
HP:0025221	biolink:PhenotypicFeature	Triggered by pregnancy	Applies to a sign or symptom that is provoked or brought about by pregnancy in a female.		hp.json	Pregnancy triggered symptoms|Triggered by pregnancy	http://purl.obolibrary.org/obo/HP_0025221		
UBERON:0006003	biolink:AnatomicalEntity	integumentary adnexa	Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers.	EMAPA:37883|Wikipedia:Skin_appendage	hp.json	body hair or bristle|skin appendage|skin adnexa|adnexae cutis|skin appendage|adnexae cutis|skin adnexa|skin adnexal structure	http://purl.obolibrary.org/obo/UBERON_0006003		pheno_slim
UBERON:0006002	biolink:AnatomicalEntity	vitelline artery	The paired arteries that carry blood to the yolk sac from the dorsal aorta.	EHDAA2:0002208|Wikipedia:Vitelline_arteries|EMAPA:16207	hp.json		http://purl.obolibrary.org/obo/UBERON_0006002		pheno_slim
CHEBI:422	biolink:ChemicalSubstance	(S)-lactic acid	An optically active form of lactic acid having (S)-configuration.	PMID:22538963|Gmelin:362717|PMID:22367529|PMID:22534372|PMID:22461545|Reaxys:1720251|Beilstein:1720251|CAS:79-33-4|PMID:22424924|HMDB:HMDB0000190|CAS:79-33-4|KEGG:C00186|CAS:79-33-4|PMID:21996028|PMID:22443585|Wikipedia:Lactic_Acid|KNApSAcK:C00001191|PMID:22578598|PMID:22336740	hp.json	(S)-(+)-lactic acid|(2S)-2-hydroxypropanoic acid|(+)-lactic acid|(S)-2-hydroxypropionic acid|L-(+)-alpha-hydroxypropionic acid|L-(+)-lactic acid|L-Milchsaeure|L-Lactic acid|(S)-2-hydroxypropanoic acid	http://purl.obolibrary.org/obo/CHEBI_422		3_STAR
HP:0025291	biolink:PhenotypicFeature	Lower-body predominance	Applies to an abnormality that affects the legs more than the arms, trunk, head.		hp.json		http://purl.obolibrary.org/obo/HP_0025291		
CHEBI:16015	biolink:ChemicalSubstance	L-glutamic acid	An optically active form of glutamic acid having L-configuration.	Wikipedia:L-Glutamic_Acid|LINCS:LSM-36375|PMID:16892196|MetaCyc:GLT|CAS:56-86-0|PMID:15930465|BPDB:2297|Gmelin:3502|HMDB:HMDB0000148|Reaxys:1723801|Beilstein:1723801|CAS:56-86-0|PDBeChem:GLU_LFOH|CAS:56-86-0|PMID:15739367|KNApSAcK:C00001358|PMID:22735334|PMID:22219301|PMID:19581495|DrugBank:DB00142|KEGG:D00007|PMID:16719819|Drug_Central:1310|KEGG:C00025	hp.json	Glutamate|L-Glutaminsaeure|GLUTAMIC ACID|E|acido glutamico|L-Glutaminic acid|L-glutamic acid|(S)-2-aminopentanedioic acid|glutamic acid|(2S)-2-aminopentanedioic acid|Glu|L-Glu|L-Glutamic acid|acide glutamique|(S)-glutamic acid|acidum glutamicum	http://purl.obolibrary.org/obo/CHEBI_16015		3_STAR
HP:0025292	biolink:PhenotypicFeature	Acral	Applies to an abnormality that affects the distal portions of limbs (hand, foot) and head (ears, nose).		hp.json		http://purl.obolibrary.org/obo/HP_0025292		
UBERON:0006009	biolink:AnatomicalEntity	cusp of cardiac valve	The part of the heart valves that serves to seal the heart valves when closed. There are three cusps for each valve except for the mitral valve, which has only two (hence its alternate name, 'bicuspid valve'). 'Nodules' are located at the tip of the valve, to form a tighter seal[WP].	NCIT:C33849|FMA:7232|UMLS:C0225923	hp.json	cardiac valvular cusp|cardiac valve cusp|cardiac valvule|cardial valve cusp|semilunar valvule	http://purl.obolibrary.org/obo/UBERON_0006009		
HP:0025293	biolink:PhenotypicFeature	Distributed along Blaschko lines	Applies to an abnormality whose localization corresponds to the lines of Blaschko, which correspond to the lineage of epithelia cells. Blaschko lines are normally invisible but may become apparent with certain skin diseases and then can be seen to be distributed in lines horizontal to the body.		hp.json		http://purl.obolibrary.org/obo/HP_0025293		
HP:0025294	biolink:PhenotypicFeature	Dermatomal	Applies to an abnormality whose localization corresponds to the dermatomes, i.e., the nerve root distribution.		hp.json	Radicular	http://purl.obolibrary.org/obo/HP_0025294		
UBERON:0006008	biolink:AnatomicalEntity	fibrous ring of heart	A ring of ribrous tissue that surrounds the atrioventricular and arterial orifices.	BTO:0003628|FMA:9497|EMAPA:37422	hp.json	coronary tendon|Lower's ring|anulus fibrosus of heart|fibrous ring of heart|anulus fibrosus cordis|annulus fibrosus cordis|aortic annulus|atrioventricular ring	http://purl.obolibrary.org/obo/UBERON_0006008		
CHEBI:16010	biolink:ChemicalSubstance	5-oxoproline	An oxoproline having the oxo group placed at the 5-position. It is an intermediate metabolite in the glutathione cycle.	Reaxys:82131|Beilstein:82131|Wikipedia:Pyroglutamic_acid|PMID:23217740|CAS:149-87-1|PMID:22770225|CAS:149-87-1|PMID:17439666	hp.json	5-oxoproline|5-Pyrrolidone-2-carboxylic acid|5-oxopyrrolidine-2-carboxylic acid|Pyroglutamic acid|Pyroglutamate|5-Oxoproline|2-pyrrolidone-5-carboxylic acid|Glp|5-OXOPROLINE|5-oxo-DL-proline	http://purl.obolibrary.org/obo/CHEBI_16010		3_STAR
HP:0025295	biolink:PhenotypicFeature	Herpetiform	Applies to an abnormality whose distribution and appearance resembles that of the grouped umbilicated vesicles seen in herpes simplex and herpes zoster infections.		hp.json		http://purl.obolibrary.org/obo/HP_0025295		
HP:0025296	biolink:PhenotypicFeature	Morbilliform	Applies to an abnormality whose distribution and appearance resembles that of measles, i.e., maculopapular lesions that are red and roughly 2 to 10 mm in diameter and may be partially confluent.		hp.json		http://purl.obolibrary.org/obo/HP_0025296		
HP:0025297	biolink:PhenotypicFeature	Prolonged	Applied to an abnormality whose duration is extended over a longer period of time than is expected or usual (e.g., prolonged fever lasts longer than one usually sees with an infection).		hp.json		http://purl.obolibrary.org/obo/HP_0025297		
NCBITaxon:451864	biolink:OrganismalEntity	Dikarya		PMID:17572334|PMID:16151185|PMID:17051209|GC_ID:1|PMID:15689432|PMID:17010206	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_451864		
HP:0025290	biolink:PhenotypicFeature	Upper-body predominance	Applies to an abnormality that affects the arms, trunk, head more than the legs.		hp.json		http://purl.obolibrary.org/obo/HP_0025290		
NCBITaxon:451866	biolink:OrganismalEntity	Taphrinomycotina		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_451866		
HP:0025289	biolink:PhenotypicFeature	Cervical lymphadenopathy	Enlarged lymph nodes in the neck.		hp.json	Swollen lymph nodes in the neck	http://purl.obolibrary.org/obo/HP_0025289		
HP:0025280	biolink:PhenotypicFeature	Pain characteristic	A pain characteristic is defined as a subjective category or type of pain.		hp.json		http://purl.obolibrary.org/obo/HP_0025280		
CHEBI:16004	biolink:ChemicalSubstance	(R)-lactate	An optically active form of lactate having (R)-configuration.	Reaxys:4655978|Beilstein:4655978|Gmelin:362716|MetaCyc:D-LACTATE|KEGG:C00256	hp.json	D-2-hydroxypropionate|D-lactate|(R)-lactate|D-2-hydroxypropanoate|(2R)-2-hydroxypropanoate	http://purl.obolibrary.org/obo/CHEBI_16004		3_STAR
HP:0025281	biolink:PhenotypicFeature	Sharp	Applied to pain that is described as sharp, i.e., sudden and severe.		hp.json		http://purl.obolibrary.org/obo/HP_0025281		
HP:0025282	biolink:PhenotypicFeature	Dull	Applied to pain that is dull, i.e., not severe but that continues over a long period of time.		hp.json	Dull pain	http://purl.obolibrary.org/obo/HP_0025282		
HP:0025283	biolink:PhenotypicFeature	Tender	Applied to pain that is tender, i.e., elicited by touching the affected body part.		hp.json		http://purl.obolibrary.org/obo/HP_0025283		
HP:0025284	biolink:PhenotypicFeature	Sleep-interrupting	Applied to pain that wakes the affecting individual from sleep.		hp.json		http://purl.obolibrary.org/obo/HP_0025284		
HP:0025285	biolink:PhenotypicFeature	Aggravated by	An aggravating factor is defined as an external factor that leads to a sign or symptom that is already present getting worse or becoming more severe.		hp.json	Exacerbated by	http://purl.obolibrary.org/obo/HP_0025285		
HP:0025286	biolink:PhenotypicFeature	Aggravated by activity	Applied to a sign or symptom that is aggravated by activity, exertion, or exercise.		hp.json	Aggravated by exercise|Worsened by activity|Worse with activity|Aggravated by exertion	http://purl.obolibrary.org/obo/HP_0025286		
HP:0025287	biolink:PhenotypicFeature	Axial	Applies to an abnormality that is situated in the central part of the body, in the head and trunk as distinguished from the limbs.		hp.json		http://purl.obolibrary.org/obo/HP_0025287		
HP:0025277	biolink:PhenotypicFeature	Gustatory sweating	Hyperhidrosis that occurs with gustatory stimulation (e.g., moisture on face from sweating that occurs after eating).		hp.json		http://purl.obolibrary.org/obo/HP_0025277		
HP:0025278	biolink:PhenotypicFeature	Cold-induced sweating	Sweating provoked by cold temperature rather than by heat.		hp.json		http://purl.obolibrary.org/obo/HP_0025278		
HP:0025279	biolink:PhenotypicFeature	Migratory			hp.json		http://purl.obolibrary.org/obo/HP_0025279		
HP:0025270	biolink:PhenotypicFeature	Abnormal esophagus physiology	Any physiological abnormality of the esophagus.		hp.json	Abnormality of oesophagus physiology|Functional abnormality of the oesophagus|Abnormality of esophagus physiology|Functional abnormality of the esophagus	http://purl.obolibrary.org/obo/HP_0025270		
HP:0025271	biolink:PhenotypicFeature	Esophageal spasms	Involuntary contractions of the esophagus that are irregular, uncoordinated, and painful.		hp.json		http://purl.obolibrary.org/obo/HP_0025271		
HP:0025272	biolink:PhenotypicFeature	Melasma	Symmetrical, blotchy, brownish facial pigmentation.		hp.json	Chloasma|Facial melanosis	http://purl.obolibrary.org/obo/HP_0025272		
HP:0025273	biolink:PhenotypicFeature	Achilles tendonitis	Inflammation of the Achilles tendon.		hp.json		http://purl.obolibrary.org/obo/HP_0025273		
HP:0025274	biolink:PhenotypicFeature	Ovarian dermoid cyst	An cystic ovarian teratoma composed of dermal and epidermal elements and containing tissue components including hair, teeth, bone, thyroid, and others.		hp.json	Mature cystic ovarian teratoma	http://purl.obolibrary.org/obo/HP_0025274		
HP:0025275	biolink:PhenotypicFeature	Lateral	Applies to an abnormality that is located farther from the median plane or midline of the body or of the referenced structure.		hp.json		http://purl.obolibrary.org/obo/HP_0025275		
HP:0025276	biolink:PhenotypicFeature	Abnormality of skin adnexa physiology	Any functional anomaly of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands.		hp.json		http://purl.obolibrary.org/obo/HP_0025276		
HP:0025266	biolink:PhenotypicFeature	obsolete Cervical osteoarthritis			hp.json		http://purl.obolibrary.org/obo/HP_0025266		
HP:0025267	biolink:PhenotypicFeature	Snoring	Deep, noisy breathing during sleep accompanied by hoarse or harsh sounds caused by the vibration of respiratory structures (especially the soft palate) resulting in sound due to obstructed air movement during breathing while sleeping.		hp.json	Snores|Snore|Snoring symptoms	http://purl.obolibrary.org/obo/HP_0025267		
HP:0025268	biolink:PhenotypicFeature	Stuttering	Disruptions in the production of speech sounds, with involuntary repetitions of words or parts of words, prolongations of speech sounds, or complete blockage of speech production for several seconds.		hp.json	Stuttering|Stammering	http://purl.obolibrary.org/obo/HP_0025268		
HP:0025269	biolink:PhenotypicFeature	Panic attack	A sudden episode of intense fear in a situation in which there is no danger or apparent cause.		hp.json	Panic attack	http://purl.obolibrary.org/obo/HP_0025269		
HP:0025260	biolink:PhenotypicFeature	Stiff wrist	A sensation of tightness in the wrist joint when attempting to move it, especially after a period of inactivity.		hp.json	Wrist stiffness|Stiff wrist	http://purl.obolibrary.org/obo/HP_0025260		
HP:0025261	biolink:PhenotypicFeature	Stiff finger	A sensation of tightness in a finger joint when attempting to move it, especially after a period of inactivity.		hp.json	Stiff finger|Finger stiffness	http://purl.obolibrary.org/obo/HP_0025261		
CHEBI:16024	biolink:ChemicalSubstance	D-mannose	A mannose with D-configuration.		hp.json	D-mannose|D-manno-hexose	http://purl.obolibrary.org/obo/CHEBI_16024		3_STAR
NCBITaxon:147554	biolink:OrganismalEntity	Schizosaccharomycetes		GC_ID:1	hp.json	Archiascomycota	http://purl.obolibrary.org/obo/NCBITaxon_147554		
HP:0025262	biolink:PhenotypicFeature	Stiff hip	A sensation of tightness in the hip joint when attempting to move it, especially after a period of inactivity.		hp.json	Hip stiffness|Stiff hip	http://purl.obolibrary.org/obo/HP_0025262		
HP:0025263	biolink:PhenotypicFeature	Stiff knee	A sensation of tightness in the knee joint when attempting to move it, especially after a period of inactivity.		hp.json	Knee stiffness|Stiff knee	http://purl.obolibrary.org/obo/HP_0025263		
HP:0025264	biolink:PhenotypicFeature	Stiff ankle	A sensation of tightness in the ankle joint when attempting to move it, especially after a period of inactivity.		hp.json	Ankle stiffness|Stiff ankle	http://purl.obolibrary.org/obo/HP_0025264		
HP:0025265	biolink:PhenotypicFeature	Stiff toe	A sensation of tightness in a toe joint when attempting to move it, especially after a period of inactivity.		hp.json	Stiff toe|Toe stiffness	http://purl.obolibrary.org/obo/HP_0025265		
HP:0003869	biolink:PhenotypicFeature	Humeral cortical thinning		UMLS:C4025541	hp.json		http://purl.obolibrary.org/obo/HP_0003869		
HP:0003868	biolink:PhenotypicFeature	Humeral cortical thickening		UMLS:C4025542	hp.json		http://purl.obolibrary.org/obo/HP_0003868		
HP:0003863	biolink:PhenotypicFeature	Angulated humerus		UMLS:C4025546	hp.json	Angulated long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003863		
HP:0003862	biolink:PhenotypicFeature	Absent humerus	Missing humerus bone associated with congenital failure of development.	UMLS:C2678399	hp.json	Aplasia of the humerus|Absent long bone in upper arm|Aplastic humerus	http://purl.obolibrary.org/obo/HP_0003862		hposlim_core
HP:0003861	biolink:PhenotypicFeature	Broad diaphyses of the upper limbs		UMLS:C4021718	hp.json	Wide shaft of long bone of the upper limbs|Broad shaft of long bone of the upper limbs|Wide diaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0003861		
HP:0003860	biolink:PhenotypicFeature	Diaphyseal sclerosis of the upper limbs	An elevation in bone density in one or more diaphyses of the arms. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4025547	hp.json	Increased bone density in central part of long bone of upper limbs	http://purl.obolibrary.org/obo/HP_0003860		
HP:0001204	biolink:PhenotypicFeature	Distal symphalangism of hands	The term distal symphalangism refers to a bony fusion of the distal and middle phalanges of the digits of the hand, in other words the distal interphalangeal joint (DIJ) is missing which can be seen either on x-rays or as an absence of the distal interphalangeal finger creases.	UMLS:C1862158	hp.json	Symphalangism affecting the distal phalanges of the hand|Synostosis of distal phalanges|Fused outermost bones of hand|Terminal symphalangism	http://purl.obolibrary.org/obo/HP_0001204		
HP:0003867	biolink:PhenotypicFeature	Humeral cortical irregularity		UMLS:C4025543	hp.json		http://purl.obolibrary.org/obo/HP_0003867		
HP:0003866	biolink:PhenotypicFeature	Coarse humeral trabeculae		UMLS:C4025544	hp.json		http://purl.obolibrary.org/obo/HP_0003866		
HP:0003865	biolink:PhenotypicFeature	Bowed humerus	A bending or abnormal curvature of the humerus.	UMLS:C1859460	hp.json	Bowing of the humerus|Humeral bowing|Bowed long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003865		hposlim_core
HP:0003864	biolink:PhenotypicFeature	Bifid humerus	Clefting affecting the humerus.	UMLS:C4025545	hp.json	Notched long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003864		
HP:0001217	biolink:PhenotypicFeature	Clubbing	Broadening of the soft tissues (non-edematous swelling of soft tissues) of the digital tips in all dimensions associated with an increased longitudinal and lateral curvature of the nails.	SNOMEDCT_US:367004|UMLS:C0149651	hp.json	Digital clubbing|Clubbing of fingers and toes	http://purl.obolibrary.org/obo/HP_0001217		
HP:0001218	biolink:PhenotypicFeature	Autoamputation	Spontaneous detachment (amputation) of an appendage from the body.	UMLS:C1833222	hp.json		http://purl.obolibrary.org/obo/HP_0001218		
HP:0003879	biolink:PhenotypicFeature	Humeral pseudarthrosis		UMLS:C4025532	hp.json	False joint (long bone in upper arm)	http://purl.obolibrary.org/obo/HP_0003879		
HP:0001211	biolink:PhenotypicFeature	Abnormal fingertip morphology	An abnormal structure of the tip (end) of a finger.	UMLS:C4025796	hp.json	Abnormality of the fingertips	http://purl.obolibrary.org/obo/HP_0001211		
HP:0003874	biolink:PhenotypicFeature	Humerus varus		UMLS:C4025537	hp.json		http://purl.obolibrary.org/obo/HP_0003874		hposlim_core
HP:0001212	biolink:PhenotypicFeature	Prominent fingertip pads	A soft tissue prominence of the ventral aspects of the fingertips. The term "persistent fetal fingertip pads" is often used as a synonym, but should better not be used because it implies knowledge of history of the patient which often does not exist.	UMLS:C1835807	hp.json	Persistent fetal fingertip pads|Prominent finger pads|Persistent foetal fingertip pads|Persistence of fingerpads|Prominent fingertip pads	http://purl.obolibrary.org/obo/HP_0001212		hposlim_core
HP:0003872	biolink:PhenotypicFeature	Humeral exostoses	Presence of more than one exostosis originating in one or noth humerus bones. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage.	UMLS:C4025538	hp.json		http://purl.obolibrary.org/obo/HP_0003872		
HP:0003871	biolink:PhenotypicFeature	Deformed humerus		UMLS:C4025539	hp.json	Deformed long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003871		
HP:0003878	biolink:PhenotypicFeature	Periosteal new bone of humerus		UMLS:C4025533	hp.json		http://purl.obolibrary.org/obo/HP_0003878		
HP:0001215	biolink:PhenotypicFeature	Camptodactyly of 2nd-5th fingers	The distal interphalangeal joint and/or the proximal interphalangeal joint of the second to fifth fingers cannot be extended to 180 degrees by either active or passive extension.	UMLS:C1859368	hp.json		http://purl.obolibrary.org/obo/HP_0001215		
HP:0001216	biolink:PhenotypicFeature	Delayed ossification of carpal bones	Ossification of carpal bones occurs later than age-adjusted norms.	UMLS:C4280599|UMLS:C1841684	hp.json	Delayed carpal ossification|Delayed maturation of wrist bone|Carpal delayed ossification|Delayed maturation of carpal bones|Delayed carpal bone age	http://purl.obolibrary.org/obo/HP_0001216		hposlim_core
HP:0003877	biolink:PhenotypicFeature	Oval transradiancy of humerus		UMLS:C4025534	hp.json	Humeral oval transradiancy	http://purl.obolibrary.org/obo/HP_0003877		
HP:0003876	biolink:PhenotypicFeature	Osteoporotic humerus		UMLS:C4025535	hp.json		http://purl.obolibrary.org/obo/HP_0003876		
HP:0003875	biolink:PhenotypicFeature	Humeral lytic defects	Destruction of an area of humerus bone due to a disease process, such as cancer.	UMLS:C4025536	hp.json	Lytic defects of the humerus	http://purl.obolibrary.org/obo/HP_0003875		
OBO:hp#layperson	biolink:NamedThing	layperson term			hp.json		http://purl.obolibrary.org/obo/hp#layperson		
GO:0016595	biolink:MolecularActivity	glutamate binding	Binding to glutamate, the anion of 2-aminopentanedioic acid.		hp.json	glutamic acid binding	http://purl.obolibrary.org/obo/GO_0016595		
GO:0016597	biolink:MolecularActivity	amino acid binding	Binding to an amino acid, organic acids containing one or more amino substituents.		hp.json		http://purl.obolibrary.org/obo/GO_0016597		goslim_pir|goslim_metagenomics
NCBITaxon:147537	biolink:OrganismalEntity	Saccharomycotina		GC_ID:1	hp.json	true yeasts	http://purl.obolibrary.org/obo/NCBITaxon_147537		
HP:0003870	biolink:PhenotypicFeature	Crumpled humerus		UMLS:C4025540	hp.json	Crumpled long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003870		
HP:0003849	biolink:PhenotypicFeature	Flared upper limb metaphysis	The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones of the arm.	UMLS:C4021721	hp.json	Flared metaphyses of the upper limbs|Flared wide portion of the upper limb bone	http://purl.obolibrary.org/obo/HP_0003849		
HP:0003848	biolink:PhenotypicFeature	Cupped metaphyses of the upper limbs		UMLS:C4025555	hp.json	Cupped wide portion of the upper limb bone	http://purl.obolibrary.org/obo/HP_0003848		
HP:0003846	biolink:PhenotypicFeature	Wide epiphyseal plates of the upper limbs		UMLS:C4020913	hp.json	Broad epiphyseal plates of the upper limbs|Broad growth plates of upper limbs	http://purl.obolibrary.org/obo/HP_0003846		
HP:0003841	biolink:PhenotypicFeature	Fragmented epiphyses of the upper limbs		UMLS:C4025559	hp.json	Fragmented end part of upper limb bones	http://purl.obolibrary.org/obo/HP_0003841		
HP:0003840	biolink:PhenotypicFeature	Delayed upper limb epiphyseal ossification	A delay in the process of formation and maturation of the epiphysis of one or more long bones of the upper limbs.	UMLS:C4025560|UMLS:C4280544	hp.json	Delayed maturation fo the end part of the upper limb bone	http://purl.obolibrary.org/obo/HP_0003840		
HP:0003844	biolink:PhenotypicFeature	Small epiphyses of the upper limbs		UMLS:C4025556	hp.json	Small end part of upper limb bones	http://purl.obolibrary.org/obo/HP_0003844		
HP:0003843	biolink:PhenotypicFeature	Round epiphyses of the upper limbs		UMLS:C4025557	hp.json	Round end part of upper limb bones	http://purl.obolibrary.org/obo/HP_0003843		
HP:0003842	biolink:PhenotypicFeature	Irregular epiphyses of the upper limbs		UMLS:C4025558	hp.json	Irregular end part of upper limb bones	http://purl.obolibrary.org/obo/HP_0003842		
HP:0003859	biolink:PhenotypicFeature	Cortical diaphyseal thickening of the upper limbs		UMLS:C4025548	hp.json		http://purl.obolibrary.org/obo/HP_0003859		
HP:0003858	biolink:PhenotypicFeature	Cortical diaphyseal irregularity of the upper limbs		UMLS:C4025549	hp.json		http://purl.obolibrary.org/obo/HP_0003858		
HP:0003852	biolink:PhenotypicFeature	Normal density transverse bands in metaphyses of the upper limbs		UMLS:C4025553	hp.json		http://purl.obolibrary.org/obo/HP_0003852		
HP:0003851	biolink:PhenotypicFeature	Lytic defects in metaphyses of the upper limbs		UMLS:C4025554	hp.json		http://purl.obolibrary.org/obo/HP_0003851		
HP:0003850	biolink:PhenotypicFeature	Upper-limb metaphyseal irregularity		UMLS:C4021720	hp.json	Irregular metaphyses of the upper limbs|Irregular wide portion of upper limb bones	http://purl.obolibrary.org/obo/HP_0003850		
HP:0003856	biolink:PhenotypicFeature	Upper limb metaphyseal widening	Increased width (breadth) of metaphyses of the arms.	UMLS:C4021719	hp.json	Broad wide portion of upper limb bone|Wide/broad metaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0003856		
HP:0003855	biolink:PhenotypicFeature	Spurred metaphyses of the upper limbs		UMLS:C4025550	hp.json	Spurred wide portion of upper limb bone	http://purl.obolibrary.org/obo/HP_0003855		
HP:0003854	biolink:PhenotypicFeature	Sclerosis of metaphyses of the upper limbs		UMLS:C4025551	hp.json	Increased bone density in wide portion of the upper limb bones	http://purl.obolibrary.org/obo/HP_0003854		
HP:0003853	biolink:PhenotypicFeature	Sclerosis with transverse striations in metaphyses of the upper limbs		UMLS:C4025552	hp.json		http://purl.obolibrary.org/obo/HP_0003853		
GO:0004565	biolink:MolecularActivity	beta-galactosidase activity	Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides.	Reactome:R-HSA-2265534|Reactome:R-HSA-1630306|Reactome:R-HSA-1605624|Reactome:R-HSA-1793217|MetaCyc:BGALACT-PWY|Reactome:R-HSA-9036061|MetaCyc:3.2.1.23-RXN|EC:3.2.1.23|Reactome:R-HSA-1606312|Reactome:R-HSA-2090079	hp.json	exo-(1->4)-beta-D-galactanase activity|beta-D-galactanase activity|beta-lactosidase activity|beta-D-galactoside galactohydrolase activity|beta-D-lactosidase activity|hydrolact	http://purl.obolibrary.org/obo/GO_0004565		
HP:0025219	biolink:PhenotypicFeature	Triggered by vaccination	Applies to a sign or symptom that is provoked or brought about by a vaccination.		hp.json	Triggered by immunization|Vaccination triggered symptoms|Triggered by vaccination|Triggered by immunisation	http://purl.obolibrary.org/obo/HP_0025219		
CHEBI:28087	biolink:ChemicalSubstance	glycogen	A polydisperse, highly branched glucan composed of chains of D-glucopyranose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages. A small number of alpha(1->3) glycosidic linkages and some cumulative alpha(1->6) links also may occur. The branches in glycogen typically contain 8 to 12 glucose residues.	HMDB:HMDB0000757|KEGG:C00182|GlyTouCan:G99991IU|GlyGen:G99991IU|Wikipedia:Glycogen|CAS:9005-79-2|CAS:9005-79-2|MetaCyc:CPD0-971	hp.json	liver starch|animal starch|WURCS=2.0/1,4,3/[a2122h-1a_1-5]/1-1-1-1/a4-b1_b4-c1_b6-d1|Glycogen	http://purl.obolibrary.org/obo/CHEBI_28087		3_STAR
GO:2000382	biolink:BiologicalProcess	positive regulation of mesoderm development	Any process that activates or increases the frequency, rate or extent of mesoderm development.		hp.json		http://purl.obolibrary.org/obo/GO_2000382		
HP:0025211	biolink:PhenotypicFeature	Triggered by ethanol ingestion	Applies to a sign or symptom that is provoked or brought about by drinking or otherwise ingesting ethanol.		hp.json	Triggered by alcohol ingestion|Ethanol ingestion triggered symptoms	http://purl.obolibrary.org/obo/HP_0025211		
HP:0025212	biolink:PhenotypicFeature	Triggered by fasting	Applies to a sign or symptom that is provoked or brought about by abstaining from eating food (fasting).		hp.json	Fasting triggered symptoms|Triggered by fasting|Fasting triggered attacks	http://purl.obolibrary.org/obo/HP_0025212		
HP:0001245	biolink:PhenotypicFeature	Small thenar eminence	Underdevelopment of the thenar eminence with reduced palmar soft tissue mass surrounding the base of the thumb.	UMLS:C1846474	hp.json	Thenar muscle hypoplasia|Hypoplastic thenar eminences|Thenar hypoplasia|Decreased thenar eminence	http://purl.obolibrary.org/obo/HP_0001245		hposlim_core
GO:2000383	biolink:BiologicalProcess	regulation of ectoderm development	Any process that modulates the frequency, rate or extent of ectoderm development.		hp.json		http://purl.obolibrary.org/obo/GO_2000383		
HP:0025213	biolink:PhenotypicFeature	Triggered by galactose ingestion	Applies to a sign or symptom that is provoked or brought about by eating or drinking galactose. Galactose usually is ingested as lactose, which is composed of equimolar amounts of glucose and galactose.		hp.json	Triggered by ingestion of lactose-containing milk	http://purl.obolibrary.org/obo/HP_0025213		
GO:2000384	biolink:BiologicalProcess	negative regulation of ectoderm development	Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development.		hp.json		http://purl.obolibrary.org/obo/GO_2000384		
HP:0025214	biolink:PhenotypicFeature	Triggered by heat	Applies to a sign or symptom that is provoked or brought about by exposure to heat.		hp.json	Heat triggered symptoms|Triggered by heat	http://purl.obolibrary.org/obo/HP_0025214		
GO:2000385	biolink:BiologicalProcess	positive regulation of ectoderm development	Any process that activates or increases the frequency, rate or extent of ectoderm development.		hp.json		http://purl.obolibrary.org/obo/GO_2000385		
HP:0025215	biolink:PhenotypicFeature	Triggered by febrile illness	Applies to a sign or symptom that is provoked or brought about by febrile illness.		hp.json	Febrile illness triggered symptoms|Triggered by fever	http://purl.obolibrary.org/obo/HP_0025215		
HP:0001248	biolink:PhenotypicFeature	Short tubular bones of the hand	Decreased length of the tubular bones of the hand, that is, the phalanges and metacarpals.	UMLS:C4025795	hp.json	Shortened short tubular bones of the hand	http://purl.obolibrary.org/obo/HP_0001248		
HP:0001249	biolink:PhenotypicFeature	Intellectual disability	Subnormal intellectual functioning which originates during the developmental period. Intellectual disability, previously referred to as mental retardation, has been defined as an IQ score below 70.	UMLS:C4020876|UMLS:C0025362|MSH:D008607|UMLS:C0423903|SNOMEDCT_US:91138005|SNOMEDCT_US:247578003|UMLS:C3714756|SNOMEDCT_US:228156007|UMLS:C1843367|UMLS:C0917816	hp.json	Mental deficiency|Mental retardation, nonspecific|Mental-retardation|Poor school performance|Intellectual disability|Mental retardation|Nonprogressive mental retardation|Low intelligence|Nonprogressive intellectual disability|Dull intelligence	http://purl.obolibrary.org/obo/HP_0001249		
HP:0025216	biolink:PhenotypicFeature	Triggered by heavy meal	Applies to a sign or symptom that is provoked or brought about by eating large quantities of food, for instance, by a heavy meal.		hp.json	Triggered by overeating|Heavy meal triggered symptoms	http://purl.obolibrary.org/obo/HP_0025216		
HP:0025217	biolink:PhenotypicFeature	Triggered by high-fat diet	Applies to a sign or symptom that is provoked or brought about by eating a diet high in lipids.		hp.json	High-fat diet triggered symptoms|Triggered by high-fat diet	http://purl.obolibrary.org/obo/HP_0025217		
HP:0025218	biolink:PhenotypicFeature	Triggered by hyperventilation	Applies to a sign or symptom that is provoked or brought about by excessively rapid and deep breathing.		hp.json	Triggered by hyperventilation|Hyperventilation triggered symptoms	http://purl.obolibrary.org/obo/HP_0025218		
HP:0001241	biolink:PhenotypicFeature	Capitate-hamate fusion		UMLS:C1857002	hp.json	Fusion of hamate and capitate|Fused capitate and hamate|Capitate-hamate fusions|Fusion of capitate and hamate	http://purl.obolibrary.org/obo/HP_0001241		
GO:2000380	biolink:BiologicalProcess	regulation of mesoderm development	Any process that modulates the frequency, rate or extent of mesoderm development.		hp.json		http://purl.obolibrary.org/obo/GO_2000380		
HP:0025210	biolink:PhenotypicFeature	Triggered by glucose ingestion	Applies to a sign or symptom that is provoked or brought about by eating or drinking glucose.		hp.json		http://purl.obolibrary.org/obo/HP_0025210		
GO:2000381	biolink:BiologicalProcess	negative regulation of mesoderm development	Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.		hp.json		http://purl.obolibrary.org/obo/GO_2000381		
CHEBI:16094	biolink:ChemicalSubstance	thiosulfate(2-)	A divalent inorganic anion obtained by removal of both protons from thiosulfuric acid.	CAS:14383-50-7|Gmelin:2031|PDBeChem:THJ	hp.json	Hyposulfite|trioxidosulfidosulfate(2-)|trioxido-1kappa(3)O-disulfate(S--S)(2-)|sulfurothioate|S2O3|TETRATHIONATE|Thiosulfate|thiosulfate ion(2-)|thiosulphate|thiosulfate|[SO3S](2-)|S2O3(2-)	http://purl.obolibrary.org/obo/CHEBI_16094		3_STAR
HP:0025208	biolink:PhenotypicFeature	Triggered by carbohydrate ingestion	Applies to a sign or symptom that is provoked or brought about by eating or drinking carbohydrates.		hp.json	Carbohydrate ingestion triggered symptoms|Triggered by carbohydrate ingestion	http://purl.obolibrary.org/obo/HP_0025208		
HP:0025209	biolink:PhenotypicFeature	Triggered by fructose ingestion	Applies to a sign or symptom that is provoked or brought about by eating or drinking fructose.		hp.json	Trigged by fruit sugar	http://purl.obolibrary.org/obo/HP_0025209		
HP:0025200	biolink:PhenotypicFeature	Muscle fiber actin filament accumulation	Accumulation in muscle cells of filaments composed of actin.		hp.json	Muscle fibre actin filament accumulation	http://purl.obolibrary.org/obo/HP_0025200		
HP:0025201	biolink:PhenotypicFeature	Abnormal circulating apolipoprotein concentration	A deviation from the normal concentration in blood of an apolipoprotein, i.e., of a protein that binds lipids to form lipoprotein and is thereby responsible for the transport of lipids in the blood and lymph circulation.		hp.json	Abnormal apolipoprotein level	http://purl.obolibrary.org/obo/HP_0025201		
HP:0001256	biolink:PhenotypicFeature	Intellectual disability, mild	Mild intellectual disability is defined as an intelligence quotient (IQ) in the range of 50-69.	UMLS:C0026106|SNOMEDCT_US:86765009	hp.json	Mild and nonprogressive mental retardation|Mild mental retardation|Intellectual disability, mild|Mental retardation, borderline-mild|Mental retardation, mild	http://purl.obolibrary.org/obo/HP_0001256		
HP:0025202	biolink:PhenotypicFeature	Elevated circulating apolipoprotein A-IV concentration	An increased concentration in blood of apolipoprotein A-IV, a major component of HDL and chylomicrons that has a role in VLDL secretion and catabolism and is required for efficient activation of lipoprotein lipase by ApoC-II.		hp.json	Elevated apolipoprotein A-IV level	http://purl.obolibrary.org/obo/HP_0025202		
HP:0025203	biolink:PhenotypicFeature	Caput medusae	Distended and engorged umbilical veins which are seen radiating from the umbilicus across the abdomen to join systemic veins.		hp.json	Palm tree sign	http://purl.obolibrary.org/obo/HP_0025203		
HP:0001254	biolink:PhenotypicFeature	Lethargy	A state of disinterestedness, listlessness, and indifference, resulting in difficulty performing simple tasks or concentrating.	MSH:D053609|SNOMEDCT_US:214264003|UMLS:C0023380	hp.json	Lethargy	http://purl.obolibrary.org/obo/HP_0001254		
HP:0001259	biolink:PhenotypicFeature	Coma	Complete absence of wakefulness and content of conscience, which manifests itself as a lack of response to any kind of external stimuli.	ICD-10:R40.2|UMLS:C0009421|MSH:D003128|SNOMEDCT_US:371632003	hp.json	Coma	http://purl.obolibrary.org/obo/HP_0001259		
HP:0025204	biolink:PhenotypicFeature	Triggered by	A trigger is defined as an external factor that leads to the manifestation of a sign or symptom in a person with a susceptibility to developing that manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0025204		
HP:0025205	biolink:PhenotypicFeature	Triggered by breast feeding	Applies to a sign or symptom that is provoked or brought about by breast feeding in an infant.		hp.json	Triggered by breastfeeding|Breastfeeding triggered symptoms	http://purl.obolibrary.org/obo/HP_0025205		
HP:0001257	biolink:PhenotypicFeature	Spasticity	A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes.	UMLS:C0026838|SNOMEDCT_US:397790002|MSH:D009128|SNOMEDCT_US:221360009	hp.json	Muscular spasticity|Muscle spasticity|Involuntary muscle stiffness, contraction, or spasm	http://purl.obolibrary.org/obo/HP_0001257		
HP:0025206	biolink:PhenotypicFeature	Triggered by cold	Applies to a sign or symptom that is provoked or brought about by exposure to cold surroundings.		hp.json	Cold triggered symptoms|Triggered by cold temperature	http://purl.obolibrary.org/obo/HP_0025206		
HP:0001258	biolink:PhenotypicFeature	Spastic paraplegia	Spasticity and weakness of the leg and hip muscles.	SNOMEDCT_US:192967009|MSH:D010264|UMLS:C0037772	hp.json	Spastic paraplegia, lower limb	http://purl.obolibrary.org/obo/HP_0001258		
HP:0025207	biolink:PhenotypicFeature	Triggered by dehydration	Applies to a sign or symptom that is provoked or brought about by being dehydrated, i.e., by a deficit in total body water.		hp.json	Dehydration triggered symptoms|Triggered by dehydration	http://purl.obolibrary.org/obo/HP_0025207		
HP:0001251	biolink:PhenotypicFeature	Ataxia	Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of elementary neurological deficits including asynergy (lack of coordination between muscles, limbs and joints), dysmetria (lack of ability to judge distances that can lead to under- or overshoot in grasping movements), and dysdiadochokinesia (inability to perform rapid movements requiring antagonizing muscle groups to be switched on and off repeatedly).	UMLS:C0007758|SNOMEDCT_US:85102008|MSH:D002524	hp.json	Cerebellar ataxia	http://purl.obolibrary.org/obo/HP_0001251		
HP:0001252	biolink:PhenotypicFeature	Hypotonia	Hypotonia is an abnormally low muscle tone (the amount of tension or resistance to movement in a muscle). Even when relaxed, muscles have a continuous and passive partial contraction which provides some resistance to passive stretching. Hypotonia thus manifests as diminished resistance to passive stretching. Hypotonia is not the same as muscle weakness, although the two conditions can co-exist.	SNOMEDCT_US:398152000|SNOMEDCT_US:398151007|MSH:D009123|UMLS:C0026827	hp.json	Peripheral hypotonia|Muscle hypotonia|Low muscle tone|Muscular hypotonia|Central hypotonia|Low or weak muscle tone	http://purl.obolibrary.org/obo/HP_0001252		
HP:0001250	biolink:PhenotypicFeature	Seizure	A seizure is an intermittent abnormality of nervous system physiology characterised by a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain.	SNOMEDCT_US:91175000|MSH:D012640|SNOMEDCT_US:128613002|SNOMEDCT_US:246545002|UMLS:C0014544|SNOMEDCT_US:313307000|UMLS:C0036572|MSH:D004827|SNOMEDCT_US:84757009	hp.json	Epilepsy|Epileptic seizure|Seizures|Seizures	http://purl.obolibrary.org/obo/HP_0001250		
HP:0003885	biolink:PhenotypicFeature	Undermodeled humerus		UMLS:C4025529	hp.json		http://purl.obolibrary.org/obo/HP_0003885		
HP:0001222	biolink:PhenotypicFeature	Spatulate thumbs	Spoon-shaped, broad thumbs.	UMLS:C0241395	hp.json	Spoon shaped thumbs	http://purl.obolibrary.org/obo/HP_0001222		
GO:0016525	biolink:BiologicalProcess	negative regulation of angiogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.		hp.json	downregulation of angiogenesis|down regulation of angiogenesis|inhibition of angiogenesis|down-regulation of angiogenesis	http://purl.obolibrary.org/obo/GO_0016525		
HP:0003884	biolink:PhenotypicFeature	Triangular humerus		UMLS:C4025530	hp.json	Triangular long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003884		
HP:0001223	biolink:PhenotypicFeature	Pointed proximal second through fifth metacarpals	All of the metacarpal bones of the hand have a pointed proximal appearance.	UMLS:C1854787	hp.json		http://purl.obolibrary.org/obo/HP_0001223		
HP:0001220	biolink:PhenotypicFeature	Interphalangeal joint contracture of finger	Chronic loss of joint motion in an interphalangeal joint of a finger due to structural changes in non-bony tissue.	UMLS:C4021784	hp.json	Interphalangeal joint flexion contractures	http://purl.obolibrary.org/obo/HP_0001220		
HP:0003883	biolink:PhenotypicFeature	Tapered humerus		UMLS:C4025531	hp.json	Tapered long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003883		
GO:0016528	biolink:CellularComponent	sarcoplasm	The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.	Wikipedia:Sarcoplasm	hp.json		http://purl.obolibrary.org/obo/GO_0016528		
HP:0003882	biolink:PhenotypicFeature	Slender humerus	Reduction in diameter of the humerus.	UMLS:C4021851	hp.json	Slender long bone of upper arm	http://purl.obolibrary.org/obo/HP_0003882		
HP:0001226	biolink:PhenotypicFeature	obsolete Acral ulceration and osteomyelitis leading to autoamputation of digits			hp.json		http://purl.obolibrary.org/obo/HP_0001226		
HP:0003889	biolink:PhenotypicFeature	Abnormal deltoid tuberosity morphology		UMLS:C4025527	hp.json	Abnormality of the deltoid tuberosities	http://purl.obolibrary.org/obo/HP_0003889		
HP:0001227	biolink:PhenotypicFeature	Abnormality of the thenar eminence	An abnormality of the thenar eminence, i.e., of the muscle on the palm of the human hand just beneath the thumb.	UMLS:C4021783	hp.json	Thenar abnormality	http://purl.obolibrary.org/obo/HP_0001227		
HP:0003888	biolink:PhenotypicFeature	Flattened humeral heads		UMLS:C3808869	hp.json	Flattended head of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003888		
HP:0003887	biolink:PhenotypicFeature	Abnormal humeral head morphology		UMLS:C4025528	hp.json	Abnormal head of long bone in upper arm|Abnormality of the humeral heads	http://purl.obolibrary.org/obo/HP_0003887		
HP:0001225	biolink:PhenotypicFeature	Wrist swelling		UMLS:C0241760	hp.json	Wrist swelling	http://purl.obolibrary.org/obo/HP_0001225		
HP:0003886	biolink:PhenotypicFeature	Wide humerus		UMLS:C4021715	hp.json	Wide long bone of upper arm|Broad humerus	http://purl.obolibrary.org/obo/HP_0003886		
HP:0003881	biolink:PhenotypicFeature	Humeral sclerosis		UMLS:C4021716	hp.json	Increased bone density in long bone of upper arm|Sclerosis of humerus	http://purl.obolibrary.org/obo/HP_0003881		
HP:0003880	biolink:PhenotypicFeature	Sclerotic foci of the humerus		UMLS:C4021717	hp.json	Humeral sclerotic foci	http://purl.obolibrary.org/obo/HP_0003880		
GO:0004553	biolink:MolecularActivity	hydrolase activity, hydrolyzing O-glycosyl compounds	Catalysis of the hydrolysis of any O-glycosyl bond.	EC:3.2.1.-|Reactome:R-HSA-5694563|Reactome:R-HSA-6786652|Reactome:R-HSA-9661820	hp.json	O-glucosyl hydrolase activity	http://purl.obolibrary.org/obo/GO_0004553		
GO:0004556	biolink:MolecularActivity	alpha-amylase activity	Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units.		hp.json	1,4-alpha-D-glucan glucanohydrolase activity	http://purl.obolibrary.org/obo/GO_0004556		
HP:0001239	biolink:PhenotypicFeature	Wrist flexion contracture	A chronic loss of wrist joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevent normal movement of the joints of the wrist.	SNOMEDCT_US:202275008|UMLS:C0409345	hp.json	Wrist flexion deformity|Wrist contracture	http://purl.obolibrary.org/obo/HP_0001239		
HP:0001233	biolink:PhenotypicFeature	2-3 finger syndactyly	Syndactyly with fusion of fingers two and three.	UMLS:C0432055|SNOMEDCT_US:205139009	hp.json	Syndactyly, 2-3 finger|Webbed 2nd-3rd fingers|Syndactyly 2nd-3rd fingers	http://purl.obolibrary.org/obo/HP_0001233		
HP:0003896	biolink:PhenotypicFeature	Irregular humeral epiphyses		UMLS:C4025524	hp.json	Irregular end part of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003896		
HP:0001234	biolink:PhenotypicFeature	Hitchhiker thumb	With the hand relaxed and the thumb in the plane of the palm, the axis of the thumb forms an angle of at least 90 degrees with the long axis of the hand.	UMLS:C1857269	hp.json	Hitchhiker thumb|Abducted thumb	http://purl.obolibrary.org/obo/HP_0001234		hposlim_core
HP:0003895	biolink:PhenotypicFeature	Flattened humeral epiphyses		UMLS:C4025525	hp.json	Flattened end part of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003895		
HP:0001231	biolink:PhenotypicFeature	Abnormal fingernail morphology	An abnormality of the fingernails.	UMLS:C4021782	hp.json	Abnormal fingernails|Abnormality of the fingernails	http://purl.obolibrary.org/obo/HP_0001231		
HP:0003894	biolink:PhenotypicFeature	Delayed humeral epiphyseal ossification	A delay in the process of formation and maturation of the humeral epiphysis.	UMLS:C4280543|UMLS:C4021712	hp.json	Delayed maturation of the end part of the long bone in upper arm|Delayed maturation/delayed ossification of the humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003894		
HP:0001232	biolink:PhenotypicFeature	Nail bed telangiectasia	Telangiectases in the area of the nails.	UMLS:C1838167	hp.json	Nail bed telangiectases	http://purl.obolibrary.org/obo/HP_0001232		
HP:0003893	biolink:PhenotypicFeature	Advanced ossification of the humeral epiphysis	Ossification of the humeral epiphysis at an earlier age than normal.	UMLS:C4025526|UMLS:C4020836	hp.json	Advanced maturation of the humeral epiphyses|Accelerated maturation of end part of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003893		
HP:0001238	biolink:PhenotypicFeature	Slender finger	Fingers that are disproportionately narrow (reduced girth) for the hand/foot size or build of the individual.	UMLS:C1857482	hp.json	Slender finger|Narrow fingers|Slender fingers|thin fingers	http://purl.obolibrary.org/obo/HP_0001238		hposlim_core
HP:0003899	biolink:PhenotypicFeature	Round humeral epiphyses		UMLS:C4025521	hp.json	Round end part of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003899		
HP:0003898	biolink:PhenotypicFeature	Large humeral epiphyses		UMLS:C4025522	hp.json	Large end part of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003898		
HP:0003897	biolink:PhenotypicFeature	Irregular ossification of the humeral epiphyses		UMLS:C4025523|UMLS:C4280542	hp.json	Irregular maturation of the end part of the long bone in upper arm	http://purl.obolibrary.org/obo/HP_0003897		
HP:0003892	biolink:PhenotypicFeature	Absent humeral epiphyseal ossification	Lack of formation of bone in the epiphysis of the humerus.	UMLS:C4021713	hp.json	Absent maturation of end part of long bone in upper arm|Absent ossification of the humeral epiphyses	http://purl.obolibrary.org/obo/HP_0003892		
HP:0003891	biolink:PhenotypicFeature	Abnormality of the humeral epiphysis	An anomaly of the humeral epiphysis.	UMLS:C4021714	hp.json	Abnormality of the humeral epiphyses|Abnormality of end part of the long bone of the upper arm	http://purl.obolibrary.org/obo/HP_0003891		
HP:0001230	biolink:PhenotypicFeature	Broad metacarpals	Abnormally broad metacarpal bones.	UMLS:C1842229	hp.json	Wide metacarpals|Wide long bones of hand	http://purl.obolibrary.org/obo/HP_0001230		hposlim_core
HP:0003890	biolink:PhenotypicFeature	Prominent deltoid tuberosities		UMLS:C2674600	hp.json		http://purl.obolibrary.org/obo/HP_0003890		
GO:0051078	biolink:BiologicalProcess	meiotic nuclear membrane disassembly	The cell cycle process in which the controlled breakdown of the nuclear membranes during meiotic cell division occurs.		hp.json	meiotic nuclear envelope breakdown|meiotic nuclear envelope catabolism|meiotic nuclear envelope degradation|meiotic nuclear envelope disassembly	http://purl.obolibrary.org/obo/GO_0051078		
GO:0090685	biolink:BiologicalProcess	RNA localization to nucleus	A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus.		hp.json	RNA localisation to nucleus	http://purl.obolibrary.org/obo/GO_0090685		
UBERON:0018099	biolink:AnatomicalEntity	distal mesopodial endochondral element	An endochondral element in the distal portion of the mesopodial skeleton, between the central mesopodial skeleton and the metapodial skeleton.		hp.json	distal mesopodial	http://purl.obolibrary.org/obo/UBERON_0018099		
GO:0051081	biolink:BiologicalProcess	nuclear membrane disassembly	The controlled breakdown of the nuclear membranes, for example during  cellular division.		hp.json	nuclear envelope catabolism|nuclear envelope degradation|nuclear envelope disassembly|nuclear envelope breakdown	http://purl.obolibrary.org/obo/GO_0051081		
GO:1905276	biolink:BiologicalProcess	regulation of epithelial tube formation	Any process that modulates the frequency, rate or extent of epithelial tube formation.		hp.json		http://purl.obolibrary.org/obo/GO_1905276		
GO:1905277	biolink:BiologicalProcess	negative regulation of epithelial tube formation	Any process that stops, prevents or reduces the frequency, rate or extent of epithelial tube formation.		hp.json	inhibition of epithelial tube formation|downregulation of epithelial tube formation|down-regulation of epithelial tube formation|down regulation of epithelial tube formation	http://purl.obolibrary.org/obo/GO_1905277		
GO:1905278	biolink:BiologicalProcess	positive regulation of epithelial tube formation	Any process that activates or increases the frequency, rate or extent of epithelial tube formation.		hp.json	up-regulation of epithelial tube formation|up regulation of epithelial tube formation|activation of epithelial tube formation|upregulation of epithelial tube formation	http://purl.obolibrary.org/obo/GO_1905278		
GO:1905268	biolink:BiologicalProcess	negative regulation of chromatin organization	Any process that stops, prevents or reduces the frequency, rate or extent of chromatin organization.		hp.json	inhibition of establishment or maintenance of chromatin architecture|inhibition of chromatin organisation|down-regulation of establishment or maintenance of chromatin architecture|negative regulation of establishment or maintenance of chromatin architecture|downregulation of chromatin organization|down-regulation of chromatin organisation|negative regulation of chromatin assembly/disassembly|negative regulation of chromatin organisation|negative regulation of chromatin modification|down regulation of chromatin organization|down-regulation of chromatin assembly or disassembly|negative regulation of chromatin assembly or disassembly|inhibition of chromatin organization|inhibition of chromatin assembly or disassembly|down-regulation of chromatin organization|down regulation of chromatin assembly or disassembly|downregulation of establishment or maintenance of chromatin architecture|downregulation of chromatin organisation|downregulation of chromatin assembly or disassembly|down regulation of establishment or maintenance of chromatin architecture|down regulation of chromatin organisation	http://purl.obolibrary.org/obo/GO_1905268		
GO:1905269	biolink:BiologicalProcess	positive regulation of chromatin organization	Any process that activates or increases the frequency, rate or extent of chromatin organization.		hp.json	up regulation of chromatin organization|stimulation of chromatin assembly or disassembly|up regulation of chromatin assembly or disassembly|upregulation of establishment or maintenance of chromatin architecture|upregulation of chromatin assembly or disassembly|activation of chromatin organization|upregulation of chromatin organisation|up-regulation of chromatin organization|positive regulation of chromatin assembly or disassembly|positive regulation of establishment or maintenance of chromatin architecture|positive regulation of chromatin organisation|up regulation of establishment or maintenance of chromatin architecture|up regulation of chromatin organisation|upregulation of chromatin organization|positive regulation of chromatin modification|activation of establishment or maintenance of chromatin architecture|positive regulation of chromatin assembly/disassembly|up-regulation of establishment or maintenance of chromatin architecture|up-regulation of chromatin organisation|activation of chromatin organisation|up-regulation of chromatin assembly or disassembly|activation of chromatin assembly or disassembly	http://purl.obolibrary.org/obo/GO_1905269		
GO:0051093	biolink:BiologicalProcess	negative regulation of developmental process	Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).		hp.json	downregulation of developmental process|inhibition of developmental process|down-regulation of developmental process|down regulation of developmental process	http://purl.obolibrary.org/obo/GO_0051093		
GO:0051094	biolink:BiologicalProcess	positive regulation of developmental process	Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).		hp.json	up-regulation of developmental process|up regulation of developmental process|activation of developmental process|stimulation of developmental process|upregulation of developmental process	http://purl.obolibrary.org/obo/GO_0051094		
GO:0051098	biolink:BiologicalProcess	regulation of binding	Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.		hp.json		http://purl.obolibrary.org/obo/GO_0051098		
GO:0051099	biolink:BiologicalProcess	positive regulation of binding	Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.		hp.json	up-regulation of binding|up regulation of binding|activation of binding|stimulation of binding|upregulation of binding	http://purl.obolibrary.org/obo/GO_0051099		
GO:0099003	biolink:BiologicalProcess	vesicle-mediated transport in synapse	Any vesicle-mediated transport that occurs in a synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099003		goslim_synapse
GO:1905288	biolink:BiologicalProcess	vascular associated smooth muscle cell apoptotic process	Any apoptotic process in a vascular associated smooth muscle cell.		hp.json	vascular smooth muscle cell apoptosis|vascular associated smooth muscle cell apoptosis|vascular smooth muscle cell apoptotic process|VSMC apoptosis|VSMC apoptotic process	http://purl.obolibrary.org/obo/GO_1905288		
UBERON:0006098	biolink:AnatomicalEntity	basal nuclear complex	The deep nuclei of telencephalic origin found in the basal region of the forebrain.	BAMS:BNC|EV:0100182|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=224|UMLS:C0004781|BIRNLEX:1629|BAMS:BG	hp.json	basal ganglia (anatomic)|basal nuclei|ganglia basales|corpus striatum (Savel'ev)|basal ganglia|basal nuclei of the forebrain	http://purl.obolibrary.org/obo/UBERON_0006098		
GO:0099054	biolink:BiologicalProcess	presynapse assembly	The aggregation, arrangement and bonding together of a set of components to form a presynapse.		hp.json	presynaptic terminal assembly|presynapse biogenesis	http://purl.obolibrary.org/obo/GO_0099054		goslim_synapse
GO:1905292	biolink:BiologicalProcess	regulation of neural crest cell differentiation	Any process that modulates the frequency, rate or extent of neural crest cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_1905292		
GO:1905293	biolink:BiologicalProcess	negative regulation of neural crest cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of neural crest cell differentiation.		hp.json	inhibition of neural crest cell differentiation|downregulation of neural crest cell differentiation|down-regulation of neural crest cell differentiation|down regulation of neural crest cell differentiation	http://purl.obolibrary.org/obo/GO_1905293		
HP:0001406	biolink:PhenotypicFeature	Intrahepatic cholestasis	Impairment of bile flow due to obstruction in the small bile ducts within the liver.	UMLS:C0008372|SNOMEDCT_US:4637005|MSH:D002780	hp.json	Impaired release of bile from liver	http://purl.obolibrary.org/obo/HP_0001406		
GO:1905294	biolink:BiologicalProcess	positive regulation of neural crest cell differentiation	Any process that activates or increases the frequency, rate or extent of neural crest cell differentiation.		hp.json	up-regulation of neural crest cell differentiation|up regulation of neural crest cell differentiation|activation of neural crest cell differentiation|upregulation of neural crest cell differentiation	http://purl.obolibrary.org/obo/GO_1905294		
HP:0001407	biolink:PhenotypicFeature	Hepatic cysts		UMLS:C0267834|SNOMEDCT_US:85057007	hp.json	Liver cysts	http://purl.obolibrary.org/obo/HP_0001407		
HP:0001404	biolink:PhenotypicFeature	Hepatocellular necrosis		UMLS:C1855038	hp.json	Death of liver cells|Hepatocellular loss	http://purl.obolibrary.org/obo/HP_0001404		
HP:0001405	biolink:PhenotypicFeature	Periportal fibrosis	The presence of fibrosis affecting the interlobular stroma of liver.	UMLS:C1849766	hp.json		http://purl.obolibrary.org/obo/HP_0001405		
GO:1905298	biolink:BiologicalProcess	regulation of intestinal epithelial cell development	Any process that modulates the frequency, rate or extent of intestinal epithelial cell development.		hp.json		http://purl.obolibrary.org/obo/GO_1905298		
HP:0001408	biolink:PhenotypicFeature	Bile duct proliferation	Proliferative changes of the bile ducts.	SNOMEDCT_US:20239009|UMLS:C0267818	hp.json	Proliferation of bile canaliculi	http://purl.obolibrary.org/obo/HP_0001408		
GO:1905299	biolink:BiologicalProcess	negative regulation of intestinal epithelial cell development	Any process that stops, prevents or reduces the frequency, rate or extent of intestinal epithelial cell development.		hp.json	downregulation of intestinal epithelial cell development|down regulation of intestinal epithelial cell development|inhibition of intestinal epithelial cell development|down-regulation of intestinal epithelial cell development	http://purl.obolibrary.org/obo/GO_1905299		
HP:0001409	biolink:PhenotypicFeature	Portal hypertension	Increased pressure in the portal vein.	SNOMEDCT_US:34742003|MSH:D006975|UMLS:C0020541	hp.json		http://purl.obolibrary.org/obo/HP_0001409		
HP:0001402	biolink:PhenotypicFeature	Hepatocellular carcinoma	A kind of neoplasm of the liver that originates in hepatocytes and presents macroscopically as a soft and hemorrhagic tan mass in the liver.	UMLS:C2239176|SNOMEDCT_US:109841003|MSH:D006528|SNOMEDCT_US:25370001|UMLS:C1867955|SNOMEDCT_US:187769009|UMLS:C1862761|NCIT:C3099	hp.json	Increased incidence of hepatocellular carcinoma|Increased hepatocellular carcinoma risk	http://purl.obolibrary.org/obo/HP_0001402		
HP:0001403	biolink:PhenotypicFeature	Macrovesicular hepatic steatosis	A form of hepatic steatosis characterized by the presence of large, lipid-laden vesicles in the affected hepatocytes.	UMLS:C1837256	hp.json	Macrovesicular steatosis	http://purl.obolibrary.org/obo/HP_0001403		
HP:0001400	biolink:PhenotypicFeature	obsolete Hepatic abscesses due to immunodeficiency			hp.json		http://purl.obolibrary.org/obo/HP_0001400		
HP:0001401	biolink:PhenotypicFeature	Intrahepatic biliary dysgenesis		UMLS:C1859235	hp.json		http://purl.obolibrary.org/obo/HP_0001401		
GO:0099068	biolink:BiologicalProcess	postsynapse assembly	The aggregation, arrangement and bonding together of a set of components to form a postsynapse.		hp.json	postsynapse biogenesis	http://purl.obolibrary.org/obo/GO_0099068		
HP:0001417	biolink:PhenotypicFeature	X-linked inheritance	A mode of inheritance that is observed for traits related to a gene encoded on the X chromosome.	UMLS:C0241764|MSH:D050172|SNOMEDCT_US:263934009	hp.json	monoallelic_X_hemizygous|X-linked form|X-linked	http://purl.obolibrary.org/obo/HP_0001417		
HP:0001419	biolink:PhenotypicFeature	X-linked recessive inheritance	A mode of inheritance that is observed for recessive traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked recessive disorders manifest in males (who have one copy of the X chromosome and are thus hemizygotes), but generally not in female heterozygotes who have one mutant and one normal allele.	UMLS:C1845977	hp.json	X-linked recessive	http://purl.obolibrary.org/obo/HP_0001419		
HP:0001410	biolink:PhenotypicFeature	Decreased liver function	Reduced ability of the liver to perform its functions.	SNOMEDCT_US:75183008|UMLS:C0232744|UMLS:C0086565|UMLS:C3279149|MSH:D008107|SNOMEDCT_US:77981007	hp.json	Decreased liver function|Liver dysfunction|Liver dysfunction, mild|Hepatopathy	http://purl.obolibrary.org/obo/HP_0001410		
HP:0001413	biolink:PhenotypicFeature	Micronodular cirrhosis	A type of cirrhosis characterized by the presence of small regenerative nodules.	SNOMEDCT_US:21861000|UMLS:C0267812	hp.json		http://purl.obolibrary.org/obo/HP_0001413		
HP:0001414	biolink:PhenotypicFeature	Microvesicular hepatic steatosis	A form of hepatic steatosis characterized by the presence of small, lipid-laden vesicles in the affected hepatocytes.	UMLS:C1850415	hp.json	Microvesicular steatosis	http://purl.obolibrary.org/obo/HP_0001414		
HP:0001412	biolink:PhenotypicFeature	Enteroviral hepatitis	Inflammation of the liver due to infection with enterovirus.	UMLS:C1843995	hp.json		http://purl.obolibrary.org/obo/HP_0001412		
GO:0002089	biolink:BiologicalProcess	lens morphogenesis in camera-type eye	The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.		hp.json	lens morphogenesis in camera-style eye|lens morphogenesis	http://purl.obolibrary.org/obo/GO_0002089		
GO:0014070	biolink:BiologicalProcess	response to organic cyclic compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.		hp.json	response to organic cyclic substance	http://purl.obolibrary.org/obo/GO_0014070		
GO:0002085	biolink:BiologicalProcess	inhibition of neuroepithelial cell differentiation	Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.		hp.json	negative regulation of neural plate formation|repression of premature neural plate formation	http://purl.obolibrary.org/obo/GO_0002085		
GO:0002087	biolink:BiologicalProcess	regulation of respiratory gaseous exchange by nervous system process	A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.		hp.json	regulation of respiratory gaseous exchange by neurological system process|neurological control of breathing	http://purl.obolibrary.org/obo/GO_0002087		
GO:0002088	biolink:BiologicalProcess	lens development in camera-type eye	The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.		hp.json	lens development in camera-style eye|lens development	http://purl.obolibrary.org/obo/GO_0002088		
GO:0014063	biolink:BiologicalProcess	negative regulation of serotonin secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.		hp.json	positive regulation of serotonin release|down-regulation of serotonin secretion|down regulation of serotonin secretion|inhibition of serotonin secretion|downregulation of serotonin secretion	http://purl.obolibrary.org/obo/GO_0014063		
GO:0014062	biolink:BiologicalProcess	regulation of serotonin secretion	Any process that modulates the frequency, rate or extent of the regulated release of serotonin.		hp.json	regulation of serotonin release	http://purl.obolibrary.org/obo/GO_0014062		
GO:0014061	biolink:BiologicalProcess	regulation of norepinephrine secretion	Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine.		hp.json	regulation of noradrenaline secretion	http://purl.obolibrary.org/obo/GO_0014061		
GO:0014064	biolink:BiologicalProcess	positive regulation of serotonin secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin.		hp.json	positive regulation of serotonin release|stimulation of serotonin secretion|upregulation of serotonin secretion|up-regulation of serotonin secretion|up regulation of serotonin secretion|activation of serotonin secretion	http://purl.obolibrary.org/obo/GO_0014064		
GO:0038023	biolink:MolecularActivity	signaling receptor activity	Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.		hp.json	receptor activity|receptor activity involved in signal transduction|signalling receptor activity	http://purl.obolibrary.org/obo/GO_0038023		goslim_pir|goslim_plant|goslim_flybase_ribbon|goslim_drosophila|goslim_chembl|goslim_mouse|goslim_metagenomics|goslim_agr
GO:0014075	biolink:BiologicalProcess	response to amine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.		hp.json	response to amine stimulus	http://purl.obolibrary.org/obo/GO_0014075		
UBERON:0006049	biolink:AnatomicalEntity	digit 2	A digit that is part of a digit 2 plus metapodial segment.	EMAPA:37286	hp.json	autopod digit 2|second digit|limb digit 2|digit II	http://purl.obolibrary.org/obo/UBERON_0006049		
UBERON:0006048	biolink:AnatomicalEntity	digit 1	A digit that is part of a digit 1 plus metapodial segment.	MA:0003023|EMAPA:37285	hp.json	limb digit 1|autopod digit 1|digit I|dewclaw	http://purl.obolibrary.org/obo/UBERON_0006048		pheno_slim
NCBITaxon:41665	biolink:OrganismalEntity	Neopterygii		GC_ID:1	hp.json	Neopterygi	http://purl.obolibrary.org/obo/NCBITaxon_41665		
UBERON:0006010	biolink:AnatomicalEntity	hyaloid canal	A small transparent canal running through the vitreous body from the optical nerve disc to the lens. It is formed by an invagination of the hyaloid, a membrane which encloses the vitreous body[WP].	FMA:58837	hp.json	canal of Cloquet|Stilling's canal|Cloquet's canal|canalis hyaloideus	http://purl.obolibrary.org/obo/UBERON_0006010		
PR:P13595	biolink:Protein	neural cell adhesion molecule 1 (mouse)	A neural cell adhesion molecule 1 that is encoded in the genome of mouse.	UniProtKB:P13595	hp.json	Ncam1|NCAM-1 (mouse)|N-CAM-1 (mouse)|CD56 (mouse)|mNCAM1|Ncam	http://purl.obolibrary.org/obo/PR_P13595		
GO:1905207	biolink:BiologicalProcess	regulation of cardiocyte differentiation	Any process that modulates the frequency, rate or extent of cardiocyte differentiation.		hp.json	regulation of cardiac cell differentiation|regulation of heart cell differentiation	http://purl.obolibrary.org/obo/GO_1905207		
GO:1905208	biolink:BiologicalProcess	negative regulation of cardiocyte differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of cardiocyte differentiation.		hp.json	down regulation of cardiocyte differentiation|down regulation of heart cell differentiation|inhibition of cardiocyte differentiation|downregulation of cardiac cell differentiation|inhibition of heart cell differentiation|down-regulation of cardiocyte differentiation|down-regulation of heart cell differentiation|negative regulation of heart cell differentiation|down regulation of cardiac cell differentiation|inhibition of cardiac cell differentiation|negative regulation of cardiac cell differentiation|down-regulation of cardiac cell differentiation|downregulation of cardiocyte differentiation|downregulation of heart cell differentiation	http://purl.obolibrary.org/obo/GO_1905208		
GO:1905209	biolink:BiologicalProcess	positive regulation of cardiocyte differentiation	Any process that activates or increases the frequency, rate or extent of cardiocyte differentiation.		hp.json	up-regulation of cardiac cell differentiation|upregulation of cardiocyte differentiation|activation of cardiac cell differentiation|upregulation of heart cell differentiation|positive regulation of heart cell differentiation|up regulation of cardiocyte differentiation|upregulation of cardiac cell differentiation|up regulation of heart cell differentiation|up-regulation of cardiocyte differentiation|activation of cardiocyte differentiation|up-regulation of heart cell differentiation|positive regulation of cardiac cell differentiation|activation of heart cell differentiation|up regulation of cardiac cell differentiation	http://purl.obolibrary.org/obo/GO_1905209		
GO:0051049	biolink:BiologicalProcess	regulation of transport	Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0051049		goslim_yeast
GO:0051047	biolink:BiologicalProcess	positive regulation of secretion	Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.		hp.json	stimulation of secretion|upregulation of secretion|up-regulation of secretion|up regulation of secretion|activation of secretion	http://purl.obolibrary.org/obo/GO_0051047		
GO:0051048	biolink:BiologicalProcess	negative regulation of secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.		hp.json	down-regulation of secretion|down regulation of secretion|inhibition of secretion|downregulation of secretion	http://purl.obolibrary.org/obo/GO_0051048		
UBERON:0006072	biolink:AnatomicalEntity	cervical region of vertebral column	That portion of the spine comprising the cervical vertebrae. The neck area of the spine.	FMA:24138|BTO:0004148|EHDAA:5051|EMAPA:17215|UMLS:C0728985|EHDAA2:0000238|AAO:0000092|NCIT:C69313|MA:0003154	hp.json	cervical skeleton|cervical vertebrae series|axial skeleton cervical region|cervical spinal column|cervical spine|cervical vertebral column|skeletal system of neck	http://purl.obolibrary.org/obo/UBERON_0006072		pheno_slim
UBERON:0006071	biolink:AnatomicalEntity	caudal region	Subdivision of an organism along anterior-posterior axis that is the posteriormost region, extending past the anus (or cloaca, if present), consisting of a tail in some fully formed chordates (or a tail bud in embryos). In animals that have a sacral region, this is the region immediately posterior to this.	XAO:0000087	hp.json	post-anal caudal region|tail region|postsacral region|post-anal tail region	http://purl.obolibrary.org/obo/UBERON_0006071		
GO:1905223	biolink:BiologicalProcess	epicardium morphogenesis	The developmental process by which an epicardium is generated and organized.		hp.json	visceral serous pericardium proper morphogenesis|visceral serous pericardium of heart morphogenesis|pericardium visceral mesothelium morphogenesis|heart epicardium morphogenesis	http://purl.obolibrary.org/obo/GO_1905223		
GO:1905213	biolink:BiologicalProcess	negative regulation of mitotic chromosome condensation	Any process that stops, prevents or reduces the frequency, rate or extent of mitotic chromosome condensation.		hp.json		http://purl.obolibrary.org/obo/GO_1905213		
GO:1905214	biolink:BiologicalProcess	regulation of RNA binding	Any process that modulates the frequency, rate or extent of RNA binding.		hp.json		http://purl.obolibrary.org/obo/GO_1905214		
GO:1905215	biolink:BiologicalProcess	negative regulation of RNA binding	Any process that stops, prevents or reduces the frequency, rate or extent of RNA binding.		hp.json	down-regulation of RNA binding|down regulation of RNA binding|downregulation of RNA binding|inhibition of RNA binding	http://purl.obolibrary.org/obo/GO_1905215		
UBERON:0006077	biolink:AnatomicalEntity	subdivision of vertebral column	A collection of all skeletal elements in some subdivision of the vertebral column.	FMA:16201	hp.json	vertebral subdivision|vertebral series|vertebral column subdivision|vertebral region|vertebrae series|subdivision of vertebral skeleton	http://purl.obolibrary.org/obo/UBERON_0006077		non_informative
GO:1905216	biolink:BiologicalProcess	positive regulation of RNA binding	Any process that activates or increases the frequency, rate or extent of RNA binding.		hp.json	activation of RNA binding|upregulation of RNA binding|up-regulation of RNA binding|up regulation of RNA binding	http://purl.obolibrary.org/obo/GO_1905216		
UBERON:0006076	biolink:AnatomicalEntity	caudal region of vertebral column	Subdivision of vertebral column that corresponds to the caudal subdivision of the body, containing the caudal vertebrae.	AAO:0000082|MA:0003158|EMAPA:18043	hp.json	caudal vertebrae series|tail region|caudal skeleton|axial skeleton tail region|postsacral region|caudal region	http://purl.obolibrary.org/obo/UBERON_0006076		
UBERON:0006075	biolink:AnatomicalEntity	sacral region of vertebral column	Subdivision of vertebral column that corresponds to the sacral subdivision of the body, containing the sacral vertebrae or sacrum.	GAID:32|NCIT:C33508|EMAPA:17676|AAO:0000724|MA:0003157|EHDAA:5059|EHDAA2:0001772	hp.json	sacral vertebrae series|axial skeleton sacral region|sacral skeleton|sacrum	http://purl.obolibrary.org/obo/UBERON_0006075		
UBERON:0006074	biolink:AnatomicalEntity	lumbar region of vertebral column	Subdivision of vertebral column that corresponds to the lumbar subdivision of the body, containing the lumbar vertebrae.	EHDAA:5055|BTO:0004147|GAID:31|FMA:16203|EHDAA2:0001037|NCIT:C69314|MA:0003156|EMAPA:17393	hp.json	lumbar skeleton|lumbar spine|lumbar vertebrae series|axial skeleton lumbar region|lumbar vertebral column	http://purl.obolibrary.org/obo/UBERON_0006074		pheno_slim
UBERON:0006073	biolink:AnatomicalEntity	thoracic region of vertebral column	That part of the spine comprising the thoracic vertebrae.	UMLS:C0581269|FMA:9140|EHDAA:5063|AAO:0000612|NCIT:C69315|BTO:0004150|EMAPA:17396|MA:0003155	hp.json	thoracic spine|thoracic vertebral column|thoracic vertebrae series|columna vertebralis thoracicus|axial skeleton thoracic region	http://purl.obolibrary.org/obo/UBERON_0006073		pheno_slim
GO:0051046	biolink:BiologicalProcess	regulation of secretion	Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0051046		
GO:0051059	biolink:MolecularActivity	NF-kappaB binding	Binding to NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.		hp.json		http://purl.obolibrary.org/obo/GO_0051059		
UBERON:0006061	biolink:AnatomicalEntity	process of vertebra	A process projection from a part of the vertebra such as centrum or arches. Examples: transverse process, diapophyses, parapophyses, and zygapophyses (both the cranial zygapophyses and the caudal zygapophyses).	NCIT:C116112|AAO:0000739|FMA:24530	hp.json	vertebral process|spinous process|vertebra process	http://purl.obolibrary.org/obo/UBERON_0006061		
UBERON:0006068	biolink:AnatomicalEntity	bone of tail	A bone that is part of a post-anal tail.	EMAPA:18042|MA:0000696	hp.json	tail bone|tail vertebra	http://purl.obolibrary.org/obo/UBERON_0006068		pheno_slim
UBERON:0006067	biolink:AnatomicalEntity	musculature of hindlimb zeugopod	Any collection of muscles that is part of a hindlimb zeugopod.	FMA:50211	hp.json	set of muscles of leg|muscle group of leg|leg musculature	http://purl.obolibrary.org/obo/UBERON_0006067		pheno_slim
UBERON:0006063	biolink:AnatomicalEntity	cartilaginous neural arch	One of the cartilaginous structures surrounding the embryonic spinal cord, formed by the dorsal growth of the dorsolateral arcualia; it is the primordium of the vertebral arch.	BTO:0001763	hp.json	neural arch primordium	http://purl.obolibrary.org/obo/UBERON_0006063		
UBERON:0006062	biolink:AnatomicalEntity	zygapophysis	Paired processes at the cephalic and caudal ends of the neural arch. They function as interlocking structures between adjacent vertebrae, and limit dorsoventral flexion and lateral movement of the column in the trunk region[AAO]. The articular processes or zygapophyses of a vertebra, in human anatomy contain two superior and two inferior, spring from the junctions of the pedicles and laminae. These stick out of an end of a vertebra to lock with a zygapophysis on the next vertebra, to make the backbone more stable. The superior processes project upward from a lower vertebra, and their articular surfaces are directed more or less backward. The inferior processes project downward from a higher vertebra, and their articular surfaces are directed more or less forward and outward. The articular surfaces are coated with hyaline cartilage.	FMA:11952|ZFA:0001603|TAO:0001549|AAO:0000710	hp.json	articular process of vertebra|articular process|zygapophysis|p. articularis vertebrae|processus articularis vertebrae|processus articularis (zygapophysis)|intercalarium articulating process	http://purl.obolibrary.org/obo/UBERON_0006062		vertebrate_core
GO:0051052	biolink:BiologicalProcess	regulation of DNA metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.		hp.json	regulation of DNA metabolism	http://purl.obolibrary.org/obo/GO_0051052		goslim_yeast
GO:0051053	biolink:BiologicalProcess	negative regulation of DNA metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.		hp.json	down regulation of DNA metabolic process|inhibition of DNA metabolic process|downregulation of DNA metabolic process|negative regulation of DNA metabolism|down-regulation of DNA metabolic process	http://purl.obolibrary.org/obo/GO_0051053		
GO:0051050	biolink:BiologicalProcess	positive regulation of transport	Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	up-regulation of transport|up regulation of transport|activation of transport|stimulation of transport|upregulation of transport	http://purl.obolibrary.org/obo/GO_0051050		
GO:0051051	biolink:BiologicalProcess	negative regulation of transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	down regulation of transport|inhibition of transport|downregulation of transport|down-regulation of transport	http://purl.obolibrary.org/obo/GO_0051051		
GO:0051054	biolink:BiologicalProcess	positive regulation of DNA metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA.		hp.json	up-regulation of DNA metabolic process|up regulation of DNA metabolic process|activation of DNA metabolic process|stimulation of DNA metabolic process|upregulation of DNA metabolic process|positive regulation of DNA metabolism	http://purl.obolibrary.org/obo/GO_0051054		
GO:0051055	biolink:BiologicalProcess	negative regulation of lipid biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.		hp.json	negative regulation of lipid anabolism|negative regulation of lipogenesis|negative regulation of lipid synthesis|downregulation of lipid biosynthetic process|negative regulation of lipid formation|down regulation of lipid biosynthetic process|inhibition of lipid biosynthetic process|down-regulation of lipid biosynthetic process|negative regulation of lipid biosynthesis	http://purl.obolibrary.org/obo/GO_0051055		
UBERON:0006050	biolink:AnatomicalEntity	digit 3	A digit that is part of a digit 3 plus metapodial segment.	EMAPA:37287	hp.json	autopod digit 3|third digit|digit III|limb digit 3	http://purl.obolibrary.org/obo/UBERON_0006050		
UBERON:0006058	biolink:AnatomicalEntity	multi-limb segment region	A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions).		hp.json		http://purl.obolibrary.org/obo/UBERON_0006058		non_informative
UBERON:0006056	biolink:AnatomicalEntity	posterior surface of head			hp.json		http://purl.obolibrary.org/obo/UBERON_0006056		
UBERON:0006052	biolink:AnatomicalEntity	digit 5	A digit that is part of a digit 5 plus metapodial segment.	EMAPA:37289|EMAPA:17441	hp.json	autopod digit 5|limb digit 5|fifth digit|digiti minimi|digit V	http://purl.obolibrary.org/obo/UBERON_0006052		
UBERON:0006051	biolink:AnatomicalEntity	digit 4	A digit that is part of a digit 4 plus metapodial segment.	EMAPA:37288	hp.json	fourth digit|autopod digit 4|limb digit 4|digit IV	http://purl.obolibrary.org/obo/UBERON_0006051		
UBERON:0006059	biolink:AnatomicalEntity	falx cerebri	The falx cerebri, also known as the cerebral falx, so named from its sickle-like form, is a strong, arched fold of dura mater which descends vertically in the longitudinal fissure between the cerebral hemispheres. It is narrow in front, where it is attached to the crista galli of the ethmoid; and broad behind, where it is connected with the upper surface of the tentorium cerebelli. Its upper margin is convex, and attached to the inner surface of the skull in the middle line, as far back as the internal occipital protuberance; it contains the superior sagittal sinus. Its lower margin is free and concave, and contains the inferior sagittal sinus. The falx cerebri is known to calcify with age.	EMAPA:18551|NCIT:C12890|UMLS:C0228120|FMA:83967	hp.json	cerebral falx	http://purl.obolibrary.org/obo/UBERON_0006059		pheno_slim
HP:0025376	biolink:PhenotypicFeature	Hyperglutaminuria	An increased concentration of glutamine in the urine.		hp.json	Glutaminuria	http://purl.obolibrary.org/obo/HP_0025376		
HP:0025377	biolink:PhenotypicFeature	Triggered by exertion	Applies to a sign or symptom that is provoked or brought about by exertion or physical exercise.		hp.json	Exertion triggered symptoms|Triggered by physical exercise	http://purl.obolibrary.org/obo/HP_0025377		
HP:0025379	biolink:PhenotypicFeature	Anti-thyroid peroxidase antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid peroxidase.		hp.json	Anti-TPO antibody positivity|TPOAbs	http://purl.obolibrary.org/obo/HP_0025379		
GO:0016620	biolink:MolecularActivity	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.	EC:1.2.1.-|Reactome:R-HSA-1222583	hp.json		http://purl.obolibrary.org/obo/GO_0016620		
HP:0025370	biolink:PhenotypicFeature	Abnormal ossification of the sacrum	Abnormal bone tissue formation (ossification) affecting the sacrum.		hp.json		http://purl.obolibrary.org/obo/HP_0025370		
HP:0025371	biolink:PhenotypicFeature	Delayed ossification of the sacrum	Formation of the sacrum bone tissue occurs later than age-adjusted norms.		hp.json		http://purl.obolibrary.org/obo/HP_0025371		
HP:0025372	biolink:PhenotypicFeature	Loud snoring	Particularly loud snoring, snoring at high volume.		hp.json	Have loud snoring|Has loud snoring|Heavy snoring|Snores loudly	http://purl.obolibrary.org/obo/HP_0025372		
HP:0025373	biolink:PhenotypicFeature	Interictal EEG abnormality	Interictal refers to a period of time between epileptic seizures. Electroencephalographic (EEG) patterns are important in the differential diagnosis of epilepsy, and the EEG is almost always abnormal during a seizure. Some persons with seizures may show EEG abnormalities between seizures, while others do not. In some cases, multiple interictal EEGs must be recorded before an abnormality is observed. In most cases the electrographic pattern of seizure onset is completely different from the activity recorded during interictal discharge.		hp.json		http://purl.obolibrary.org/obo/HP_0025373		
HP:0025374	biolink:PhenotypicFeature	Duplicated odontoid process	The presence of two distinct odontoid processes. The odontoid process, also known as the dens of the axis, is a protuberance of the C2 vertebral body around which the first vertebra rotates.		hp.json		http://purl.obolibrary.org/obo/HP_0025374		
HP:0025375	biolink:PhenotypicFeature	Orthotopic os odontoideum	Os odontoideum is classified into two anatomic types (orthotopic and dystopic). Os odontoideum is defined as an ossicle that consists of smooth and separate caudal portions of the odontoid process.With dystopic os odontoideum, the ossicle is located near the basion or is fused with the clivus.		hp.json		http://purl.obolibrary.org/obo/HP_0025375		
GO:0004658	biolink:MolecularActivity	propionyl-CoA carboxylase activity	Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA.	MetaCyc:PROPIONYL-COA-CARBOXY-RXN|RHEA:23720|Reactome:R-HSA-71031|EC:6.4.1.3	hp.json	propionyl coenzyme A carboxylase activity|propanoyl-CoA:carbon-dioxide ligase (ADP-forming)|PCCase activity	http://purl.obolibrary.org/obo/GO_0004658		
HP:0025367	biolink:PhenotypicFeature	Trichoepithelioma	A benign hair follicle tumor whose tumor cells form rudimentary hair follicles but not actual hair shafts. A trichoepithelioma is usually less than one centimeter, firm, round, and shihy with yellow, pink, brown, or bluish color. They may occur multiply, usually on the face, and may gradually increase in number with age.		hp.json		http://purl.obolibrary.org/obo/HP_0025367		
HP:0025368	biolink:PhenotypicFeature	Abnormal growth plate morphology	A structural anomaly of the growth plates (epiphyseal plates), areas of cartilage located near the ends of long bones that are located between the metaphysis (widened part of the shaft of the bone) and the epiphysis (end of the bone) and in which growth occurs in the developing bone. After conclusion of bone growth, the growth plates ossify (harden into solid bone).		hp.json	Abnormality of growth plate morphology	http://purl.obolibrary.org/obo/HP_0025368		
HP:0025369	biolink:PhenotypicFeature	Thick growth plates	Increased thickness (dimension along the axis of the bone) of the growth plate.		hp.json		http://purl.obolibrary.org/obo/HP_0025369		
HP:0025360	biolink:PhenotypicFeature	Polycalycosis	Increased number of calices of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0025360		
HP:0025361	biolink:PhenotypicFeature	Abnormality of medullary pyramid morphology	A structural anomaly of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla.		hp.json		http://purl.obolibrary.org/obo/HP_0025361		
HP:0025362	biolink:PhenotypicFeature	Renal medullary pyramid hypoplasia	Undergrowth of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla.		hp.json	Hypoplasia of the medullary pyramids	http://purl.obolibrary.org/obo/HP_0025362		
HP:0025363	biolink:PhenotypicFeature	Glomerular endocapillary hypercellularity	Hypercellularity due to increased number of cells within glomerular capillary lumina, causing narrowing of the lumina.		hp.json	Endocapillary hypercellularity	http://purl.obolibrary.org/obo/HP_0025363		
HP:0025364	biolink:PhenotypicFeature	Glomerular extracapillary hypercellularity	Hypercellularity (increased number of cells) in the renal glomerulus but external to the glomerular capillaries, i.e., in the Bowman space or more than one layer of parietal or visceral epithelial cells.		hp.json	Extracapillary glomerular hypercellularity|Extracapillary hypercellularity	http://purl.obolibrary.org/obo/HP_0025364		
GO:2000248	biolink:BiologicalProcess	negative regulation of establishment or maintenance of neuroblast polarity	Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity.		hp.json	negative regulation of establishment and/or maintenance of neuroblast cell polarity	http://purl.obolibrary.org/obo/GO_2000248		
HP:0001387	biolink:PhenotypicFeature	Joint stiffness	Joint stiffness is a perceived sensation of tightness in a joint or joints when attempting to move them after a period of inactivity. Joint stiffness typically subsides over time.	SNOMEDCT_US:84445001|UMLS:C0162298	hp.json	Joint stiffness|Stiff joint|Stiff joints	http://purl.obolibrary.org/obo/HP_0001387		
HP:0025354	biolink:PhenotypicFeature	Abnormal cellular phenotype	An anomaly of cellular morphology or physiology.		hp.json		http://purl.obolibrary.org/obo/HP_0025354		
HP:0025355	biolink:PhenotypicFeature	Retinal arterial macroaneurysms	Acquired focal dilatations of branches of the retinal artery, usually second-order retinal arterioles, that range in size from 100 to 200 micrometers in diameter. Macroaneurysms are generally located at the termporal retina and may be hemorrhagic or exudative.		hp.json		http://purl.obolibrary.org/obo/HP_0025355		
HP:0001388	biolink:PhenotypicFeature	Joint laxity	Lack of stability of a joint.	SNOMEDCT_US:27911000|UMLS:C0086437|SNOMEDCT_US:298203008|UMLS:C0158359|MSH:D007593	hp.json	Ligamentous laxity|Lax joints|Joint instability|Joint ligamentous laxity|Loosejointedness|Loose-jointedness|Hyperlaxity	http://purl.obolibrary.org/obo/HP_0001388		
GO:2000241	biolink:BiologicalProcess	regulation of reproductive process	Any process that modulates the frequency, rate or extent of reproductive process.		hp.json		http://purl.obolibrary.org/obo/GO_2000241		
HP:0001385	biolink:PhenotypicFeature	Hip dysplasia	The presence of developmental dysplasia of the hip.	SNOMEDCT_US:48334007|SNOMEDCT_US:52781008|UMLS:C0019555|MSH:D006618	hp.json	Abnormal formation of the hip|Congenital hip dysplasia	http://purl.obolibrary.org/obo/HP_0001385		
HP:0025356	biolink:PhenotypicFeature	obsolete Psychomotor retardation			hp.json		http://purl.obolibrary.org/obo/HP_0025356		
GO:2000242	biolink:BiologicalProcess	negative regulation of reproductive process	Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process.		hp.json		http://purl.obolibrary.org/obo/GO_2000242		
HP:0001386	biolink:PhenotypicFeature	Joint swelling		SNOMEDCT_US:271771009|UMLS:C0152031	hp.json	Joint swelling	http://purl.obolibrary.org/obo/HP_0001386		
HP:0025357	biolink:PhenotypicFeature	Erratic myoclonus	A type of myoclonus in which the myoclonias shift from body region to another in a random and asynchronous fashion. Erratic myoclonus can affect the face or limbs, are brief, single or repetitive, very frequent and nearly continuous.		hp.json	Fragmentary myoclonus	http://purl.obolibrary.org/obo/HP_0025357		
HP:0025358	biolink:PhenotypicFeature	Uveal ectropion	Presence of iris pigment epithelium on the anterior surface of the iris.		hp.json	Ectropion uveae	http://purl.obolibrary.org/obo/HP_0025358		
GO:2000243	biolink:BiologicalProcess	positive regulation of reproductive process	Any process that activates or increases the frequency, rate or extent of reproductive process.		hp.json		http://purl.obolibrary.org/obo/GO_2000243		
HP:0025359	biolink:PhenotypicFeature	Polygonal renal calices	An abnormal polygonal shape of the calices of the kidney (which normally have a rounded or cup-shaped appearance).		hp.json	Polygonal-shaped calices|Polygonal calices	http://purl.obolibrary.org/obo/HP_0025359		
HP:0001380	biolink:PhenotypicFeature	obsolete Ligamentous laxity			hp.json		http://purl.obolibrary.org/obo/HP_0001380		
HP:0025350	biolink:PhenotypicFeature	Giant conjunctival papillae	Conjunctival papillae with a diameter greater than 1 millimeter. They characteristically have flattened tops which sometimes demonstrate staining with fluorescein.		hp.json		http://purl.obolibrary.org/obo/HP_0025350		
HP:0001384	biolink:PhenotypicFeature	Abnormal hip joint morphology	An abnormality of the hip joint.	UMLS:C4020870	hp.json	Abnormality of the hip joint|Abnormality of the hip joints	http://purl.obolibrary.org/obo/HP_0001384		
HP:0025351	biolink:PhenotypicFeature	Recurrent interdigital mycosis	A history of repeated fungal infections located between the fingers or toes, usually manifested by scaling, maceration, and itching. The toes are more commonly affected than the fingers.		hp.json	Recurrent interdigital tinea	http://purl.obolibrary.org/obo/HP_0025351		
HP:0025352	biolink:PhenotypicFeature	Typically de novo	Description of conditions that are exclusively or predominantly observed to display de novo variants. In some cases, this may be due to the limited reproductive fitness of affected individuals.		hp.json	Autosomal dominant germline de novo mutation	http://purl.obolibrary.org/obo/HP_0025352		
HP:0025353	biolink:PhenotypicFeature	Anti-multiple nuclear dots antibody positivity	A type of antinuclear antibody (ANA) positivity revealed by indirect immunofluorescence (IFL). The multiple nuclear dots (MND) pattern is immunomorphologically characterized by the staining of 3-20 dots of variable size distributed all over the cell nucleus, but sparing the nucleoli, and, in contrast to the anticentromere pattern, MND reactivity does not stain the chromosomes in mitotic cells.		hp.json	Anti-MND antibodies	http://purl.obolibrary.org/obo/HP_0025353		
HP:0001382	biolink:PhenotypicFeature	Joint hypermobility	The ability of a joint to move beyond its normal range of motion.	UMLS:C1844820|SNOMEDCT_US:298181000	hp.json	Increased joint mobility|Extensible joints|Flexible joints|Double-Jointed|Joint hyperextensibility|Increased mobility of joints|Hyperextensible joints	http://purl.obolibrary.org/obo/HP_0001382		
GO:0004634	biolink:MolecularActivity	phosphopyruvate hydratase activity	Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O.	EC:4.2.1.11|Reactome:R-HSA-71660|RHEA:10164|MetaCyc:2PGADEHYDRAT-RXN|Reactome:R-HSA-70494	hp.json	2-phosphoglyceric dehydratase activity|2-phosphoglycerate dehydratase activity|gamma-enolase activity|2-phospho-D-glycerate-hydrolase activity|2-phospho-D-glycerate hydro-lyase activity|phosphoenolpyruvate hydratase activity|14-3-2-protein|enolase activity|2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)|nervous-system specific enolase|2-phosphoglycerate enolase activity	http://purl.obolibrary.org/obo/GO_0004634		
GO:2000258	biolink:BiologicalProcess	negative regulation of protein activation cascade	Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade.		hp.json	negative regulation of protein activation pathway|negative regulation of protein activitory cascade	http://purl.obolibrary.org/obo/GO_2000258		
GO:2000259	biolink:BiologicalProcess	positive regulation of protein activation cascade	Any process that activates or increases the frequency, rate or extent of protein activation cascade.		hp.json	positive regulation of protein activitory cascade|positive regulation of protein activation pathway	http://purl.obolibrary.org/obo/GO_2000259		
HP:0025343	biolink:PhenotypicFeature	Lupus anticoagulant	Presence of lupus anticoagulant (LA) autoantibodies. LA represent a heterogeneous group of autoantibodies, IgG, IgM, or a mixture of both classes, that interfere with standard phospholipid-based coagulant tests (this is only an in vitro phenomenon, LA do not cause reduction of coagulation in vivo). The antibodies are directed against plasma proteins which also bind to phospholipid surfaces.		hp.json		http://purl.obolibrary.org/obo/HP_0025343		
GO:0016614	biolink:MolecularActivity	oxidoreductase activity, acting on CH-OH group of donors	Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	EC:1.1.-.-|Reactome:R-HSA-1500781	hp.json	oxidoreductase activity, acting on the CH-OH group of donors, other acceptors	http://purl.obolibrary.org/obo/GO_0016614		
HP:0001399	biolink:PhenotypicFeature	Hepatic failure		MSH:D017093|SNOMEDCT_US:59927004|UMLS:C0085605	hp.json	Liver failure	http://purl.obolibrary.org/obo/HP_0001399		
HP:0025344	biolink:PhenotypicFeature	Interlobular bile duct destruction	Damage to and obliteration of intrahepatic bile ducts (bile ducts that transport bile between the Canals of Hering and the interlobar bile ducts).		hp.json		http://purl.obolibrary.org/obo/HP_0025344		
GO:2000252	biolink:BiologicalProcess	negative regulation of feeding behavior	Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior.		hp.json	negative regulation of drinking|negative regulation of eating|negative regulation of feeding behaviour|negative regulation of behavioural response to food|negative regulation of behavioral response to food	http://purl.obolibrary.org/obo/GO_2000252		
HP:0025345	biolink:PhenotypicFeature	Abnormality of circulating beta-2-microglobulin level	A deviation from the normal concentration of beta-2-microglobulin in the blood.		hp.json	Abnormality of circulating beta2-m level|Abnormality of circulating beta2 microglobulin level|Abnormality of circulating B2M level|Abnormality of circulating beta2m level	http://purl.obolibrary.org/obo/HP_0025345		
HP:0001396	biolink:PhenotypicFeature	Cholestasis	Impairment of bile flow due to obstruction in bile ducts.	UMLS:C0008370|SNOMEDCT_US:197446008|SNOMEDCT_US:33688009|MSH:D002779|SNOMEDCT_US:30144000	hp.json	Slowed or blocked flow of bile from liver	http://purl.obolibrary.org/obo/HP_0001396		
GO:0016616	biolink:MolecularActivity	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.	Reactome:R-HSA-975629|EC:1.1.1.-	hp.json	glycolate reductase|NADH-dependent glyoxylate reductase|glyoxylic acid reductase	http://purl.obolibrary.org/obo/GO_0016616		
GO:2000253	biolink:BiologicalProcess	positive regulation of feeding behavior	Any process that activates or increases the frequency, rate or extent of feeding behavior.		hp.json	positive regulation of feeding behaviour|positive regulation of behavioural response to food|positive regulation of eating|positive regulation of drinking|positive regulation of behavioral response to food	http://purl.obolibrary.org/obo/GO_2000253		
HP:0025346	biolink:PhenotypicFeature	Increased circulating beta-2-microglobulin level	Elevated concentration of beta-2-microglobulin in the blood.		hp.json	Elevated circulating beta-2-microglobulin level	http://purl.obolibrary.org/obo/HP_0025346		
HP:0001397	biolink:PhenotypicFeature	Hepatic steatosis	Steatosis is a term used to denote lipid accumulation within hepatocytes.	SNOMEDCT_US:197321007|MSH:D005234|UMLS:C2711227|SNOMEDCT_US:442191002	hp.json	Fatty infiltration of liver|Liver steatosis|Fatty liver|Steatosis	http://purl.obolibrary.org/obo/HP_0001397		
UBERON:0008713	biolink:AnatomicalEntity	pectoral girdle and thoracic body wall skeletal muscle		EHDAA2:0001421|EMAPA:17748|RETIRED_EHDAA2:0001422	hp.json		http://purl.obolibrary.org/obo/UBERON_0008713		
HP:0025347	biolink:PhenotypicFeature	Decreased circulating beta-2-microglobulin level	Reduced concentration of beta-2-microglobulin in the blood.		hp.json	Reduced circulating beta-2-microglobulin level	http://purl.obolibrary.org/obo/HP_0025347		
HP:0025348	biolink:PhenotypicFeature	Abnormal corneal limbus morphology	An anomaly of the margin of the cornea overlapped by the sclera.		hp.json	Abnormality of the corneal limbus	http://purl.obolibrary.org/obo/HP_0025348		
UBERON:0008715	biolink:AnatomicalEntity	muscle tissue of prostate	A muscle tissue that is part of a prostate gland.	UMLS:C1183911|NCIT:C13100	hp.json	prostatic musclular tissue|prostate gland muscle tissue|prostate muscle tissue|prostatic muscle	http://purl.obolibrary.org/obo/UBERON_0008715		
HP:0025349	biolink:PhenotypicFeature	Limbal edema	Swelling of the margin of the cornea overlapped by the sclera.		hp.json	Limbal oedema	http://purl.obolibrary.org/obo/HP_0025349		
GO:2000257	biolink:BiologicalProcess	regulation of protein activation cascade	Any process that modulates the frequency, rate or extent of protein activation cascade.		hp.json	regulation of protein activation pathway|regulation of protein activitory cascade	http://purl.obolibrary.org/obo/GO_2000257		
HP:0001394	biolink:PhenotypicFeature	Cirrhosis	A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function.	SNOMEDCT_US:19943007|MSH:D008103|UMLS:C0023890	hp.json	Hepatic cirrhosis|Scar tissue replaces healthy tissue in the liver|Liver cirrhosis	http://purl.obolibrary.org/obo/HP_0001394		
HP:0001395	biolink:PhenotypicFeature	Hepatic fibrosis	The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process.	UMLS:C0239946|MSH:D008103|SNOMEDCT_US:62484002	hp.json	Liver fibrosis	http://purl.obolibrary.org/obo/HP_0001395		
HP:0025340	biolink:PhenotypicFeature	Deep episcleral hyperemia	Prominence of blood vessels of the deep episcleral tissues.		hp.json	Deep episcleral hyperaemia	http://purl.obolibrary.org/obo/HP_0025340		
HP:0025341	biolink:PhenotypicFeature	Corneal keratic precipitates	An inflammatory cellular deposit deposited on the corneal endothelium and visible as spots on the cornea.		hp.json		http://purl.obolibrary.org/obo/HP_0025341		
HP:0001392	biolink:PhenotypicFeature	Abnormality of the liver	An abnormality of the liver.	UMLS:C4021780|MSH:D008107|UMLS:C0023895|SNOMEDCT_US:235856003	hp.json	Abnormality of the liver|Abnormal liver|Liver disease|Liver abnormality	http://purl.obolibrary.org/obo/HP_0001392		
HP:0025342	biolink:PhenotypicFeature	Central retinal artery occlusion	Blockage of the main artery in the retina. The typical presentation is one of profound monocular visual loss.		hp.json		http://purl.obolibrary.org/obo/HP_0025342		
UBERON:0018102	biolink:AnatomicalEntity	distal mesopodial bone	A distal mesopodial endochondral element that is composed primarily of a bone tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0018102		
UBERON:0018100	biolink:AnatomicalEntity	distal mesopodial cartilage element	A distal mesopodial endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0018100		
RO:0011002	biolink:NamedThing	regulates activity of	The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B.		hp.json		http://purl.obolibrary.org/obo/RO_0011002		
UBERON:0018101	biolink:AnatomicalEntity	distal mesopodial pre-cartilage condensation	A distal mesopodial endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0018101		
UBERON:0008788	biolink:AnatomicalEntity	posterior cranial fossa	The infratentorial compartment that contains the CEREBELLUM and BRAIN STEM. It is formed by the posterior third of the superior surface of the body of the sphenoid (SPHENOID BONE), by the occipital, the petrous, and mastoid portions of the TEMPORAL BONE, and the posterior inferior angle of the PARIETAL BONE.	GAID:85|CALOHA:TS-2354|MESH:D003388|UMLS:C0010265|FMA:54368|NCIT:C33361	hp.json	posterior fossa|fossa cranii posterior	http://purl.obolibrary.org/obo/UBERON_0008788		pheno_slim
UBERON:0008789	biolink:AnatomicalEntity	cranial fossa	Any of the three large depressions in the posterior, middle, and anterior aspects of the floor of the cranial cavity.	FMA:321144	hp.json		http://purl.obolibrary.org/obo/UBERON_0008789		
UBERON:0008780	biolink:AnatomicalEntity	inner cell mass derived epiblast	An embryonic structure that is derived from the inner cell mass and lies above the hypoblast and gives rise to the three primary germ layers.	EHDAA2:0000444|EHDAA:75|EHDAA:42|EMAPA:16050|NCIT:C34164|UMLS:C1516906	hp.json	embryonic epiblast	http://purl.obolibrary.org/obo/UBERON_0008780		pheno_slim|early_development
UBERON:0008783	biolink:AnatomicalEntity	dorsal venous arch	The dorsal venous arch of the foot is a superficial vein that connects the small saphenous vein and the great saphenous vein. Anatomically, it is defined by where the dorsal veins of the first and fifth digit, respectively, meet the great saphenous vein and small saphenous vein.	MA:0002110|EMAPA:37521|FMA:44356	hp.json	arcus venosus dorsalis pedis|arcus venosus dorsalis pedis|dorsal venous arch of foot	http://purl.obolibrary.org/obo/UBERON_0008783		
UBERON:0008784	biolink:AnatomicalEntity	lower limb segment	A limb segment that is part of a hindlimb.	FMA:24877	hp.json	free lower limb subdivision|subdivision of free lower limb|segment of free lower limb|free lower limb segment	http://purl.obolibrary.org/obo/UBERON_0008784		
UBERON:0006127	biolink:AnatomicalEntity	funiculus of spinal cord	A funiculus of neuraxis that is part of a spinal cord.	FMA:77460	hp.json	spinal cord funiculus|white column of spinal cord	http://purl.obolibrary.org/obo/UBERON_0006127		
UBERON:0008785	biolink:AnatomicalEntity	upper limb segment	A limb segment that is part of a forelimb.	FMA:24876	hp.json	free upper limb subdivision|subdivision of free upper limb|segment of free upper limb|free upper limb segment	http://purl.obolibrary.org/obo/UBERON_0008785		
UBERON:0008777	biolink:AnatomicalEntity	hypaxial musculature	Musculature that is derived from the hypaxial myotome region, trunk muscles that lie ventral to the horizontal septum of the vertebrae. Hypaxial muscles include some vertebral muscles, the diaphragm, the abdominal muscles, and all limb muscles.	XAO:0003228|AAO:0000228|EMAPA:37852	hp.json	hypaxial muscle|hypaxial muscles	http://purl.obolibrary.org/obo/UBERON_0008777		
UBERON:0008778	biolink:AnatomicalEntity	epaxial musculature	Musculature that is derived from the epaxial myotome region, ventral to the horizontal septum of the vertebrae. Epaxial muscles include other (dorsal) muscles associated with the vertebrae, ribs, and base of the skull.	AAO:0000142|XAO:0003229|EMAPA:37851	hp.json	epaxial muscles|epaxial muscle	http://purl.obolibrary.org/obo/UBERON_0008778		pheno_slim
UBERON:0008772	biolink:AnatomicalEntity	proximal epiphysis of tibia	A proximal epiphysis that is part of a tibia.	NCIT:C32722|UMLS:C0932431|FMA:33113	hp.json	upper end of tibia|head of tibia|proximal tibial epiphysis|proximal end of tibia	http://purl.obolibrary.org/obo/UBERON_0008772		pheno_slim
GO:0004619	biolink:MolecularActivity	phosphoglycerate mutase activity	Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate.	EC:5.4.2.1|Reactome:R-HSA-71445|Reactome:R-HSA-71654|MetaCyc:3PGAREARR-RXN|RHEA:15901	hp.json	monophosphoglycerate mutase activity|PGA mutase activity|phosphoglycerate phosphomutase activity|diphosphoglycomutase|phosphoglyceromutase activity|GriP mutase|PGM|monophosphoglyceromutase activity|D-phosphoglycerate 2,3-phosphomutase activity|PGAM activity|bisphosphoglyceromutase|MPGM	http://purl.obolibrary.org/obo/GO_0004619		
UBERON:0008775	biolink:AnatomicalEntity	proximal epiphysis of fibula	A proximal epiphysis that is part of a fibula.	EMAPA:37890|galen:HeadOfFibula|UMLS:C0223908|FMA:33729|NCIT:C32719	hp.json	upper end of fibula|caput fibulae|proximal end of fibula|head of fibula|fibular head	http://purl.obolibrary.org/obo/UBERON_0008775		pheno_slim
GO:0004618	biolink:MolecularActivity	phosphoglycerate kinase activity	Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+).	Reactome:R-HSA-70486|EC:2.7.2.3|Reactome:R-HSA-71850|KEGG_REACTION:R01512|RHEA:14801|MetaCyc:PHOSGLYPHOS-RXN	hp.json	phosphoglyceric acid kinase activity|glycerophosphate kinase activity|glycerate 3-phosphate kinase activity|phosphoglycerokinase activity|PGK|3-phosphoglyceric kinase activity|3-phosphoglyceric acid kinase activity|3-phosphoglycerate kinase activity|ATP:D-3-phosphoglycerate 1-phosphotransferase activity|phosphoglyceric kinase activity|3-phosphoglycerate phosphokinase activity|3-phosphoglyceric acid phosphokinase activity|3-PGK|ATP-3-phospho-D-glycerate-1-phosphotransferase activity|ATP:3-phospho-D-glycerate 1-phosphotransferase activity	http://purl.obolibrary.org/obo/GO_0004618		
CL:4030000	biolink:Cell	choroidal melanocyte	A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses.		hp.json	uveal melanocyte	http://purl.obolibrary.org/obo/CL_4030000		
CL:4030002	biolink:Cell	effector memory CD45RA-positive, alpha-beta T cell, terminally differentiated	An alpha-beta memory T cell with the phenotype CD45RA-positive.		hp.json	TEMRA cell|terminally differentiated effector memory CD45RA+ T cells|terminally differentiated effector memory cells re-expressing CD45RA|effector memory RA T cell|TEMRA	http://purl.obolibrary.org/obo/CL_4030002		
HP:0025398	biolink:PhenotypicFeature	Nodular-perilymphatic pattern on pulmonary HRCT	A nodular pattern on pulmonary high-resolution computed tomography that has a perilymphatic distribution.		hp.json		http://purl.obolibrary.org/obo/HP_0025398		
HP:0025399	biolink:PhenotypicFeature	Nodular-centrilobular with tree-in-bud pattern on pulmonary HRCT	A nodular pattern on pulmonary high-resolution computed tomography that displays a tree-in-bud pattern, representing centrilobular branching structures that resemble a budding tree.		hp.json		http://purl.obolibrary.org/obo/HP_0025399		
HP:0025390	biolink:PhenotypicFeature	Reticular pattern on pulmonary HRCT	On pulmonary high-resolution computed tomography, reticular pattern is characterised by innumerable interlacing shadows suggesting a mesh.		hp.json		http://purl.obolibrary.org/obo/HP_0025390		
HP:0025391	biolink:PhenotypicFeature	Crazy paving pattern	The so-called crazy paving pattern appears as thickened interlobular septa and intralobular lines superimposed on a background of ground-glass opacity, resembling irregularly shaped paving stones. The crazy-paving pattern is often sharply demarcated from more normal lung and may have a geographic outline. It was originally reported in patients with alveolar proteinosis and is also encountered in other diffuse lung diseases that affect both the interstitial and airspace compartments, such as lipoid pneumonia.		hp.json	Crazy-paving pattern|Crazy paving pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025391		
HP:0025392	biolink:PhenotypicFeature	Nodular pattern on pulmonary HRCT	A nodular pattern is characterised on pulmonary high-resolution computed tomography by the presence of numerous rounded opacities that range from 2 mm to 1 cm in diameter, with micronodules defined as smaller than 3 mm in diameter.		hp.json		http://purl.obolibrary.org/obo/HP_0025392		
HP:0025393	biolink:PhenotypicFeature	Reticulonodular pattern on pulmonary HRCT	Co-occurrence of reticular and micronodular patterns on pulmonary high-resolution computed tomography.		hp.json		http://purl.obolibrary.org/obo/HP_0025393		
HP:0025394	biolink:PhenotypicFeature	Cystic pattern on pulmonary HRCT	On pulmonary high-resolution computed tomography, the cystic pattern is composed by well-defined, round and circumscribed air-containing parenchymal spaces with a well-defined wall and interface with normal lung. The wall of the cysts may be uniform or varied in thickness, but usually is thin (less than 2 mm) and occurs without associated emphysema.		hp.json		http://purl.obolibrary.org/obo/HP_0025394		
HP:0025395	biolink:PhenotypicFeature	Combined cystic and ground-glass pattern on pulmonary HRCT	Co-occurrence of the cystic pattern and the ground-glass pattern on pulmonary high-resolution computed tomography,		hp.json		http://purl.obolibrary.org/obo/HP_0025395		
HP:0025396	biolink:PhenotypicFeature	Decreased attenuation pattern on pulmonary HRCT	Areas of low density corresponding to parenchymal destruction and reduced perfusion, and attenuation of the pulmonary vasculature, as visualized on pulmonary high-resolution computed tomography.		hp.json	Black lung pattern on pulmonary HRCT	http://purl.obolibrary.org/obo/HP_0025396		
HP:0025397	biolink:PhenotypicFeature	Mosaic attenuation pattern on pulmonary HRCT	A patchwork of intermingled areas of increased and decreased attenuation visualized on pulmonary high-resolution computed tomography.		hp.json		http://purl.obolibrary.org/obo/HP_0025397		
GO:2000214	biolink:BiologicalProcess	regulation of proline metabolic process	Any process that modulates the frequency, rate or extent of proline metabolic process.		hp.json	regulation of proline metabolism	http://purl.obolibrary.org/obo/GO_2000214		
GO:2000215	biolink:BiologicalProcess	negative regulation of proline metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process.		hp.json	negative regulation of proline metabolism	http://purl.obolibrary.org/obo/GO_2000215		
GO:2000216	biolink:BiologicalProcess	positive regulation of proline metabolic process	Any process that activates or increases the frequency, rate or extent of proline metabolic process.		hp.json	positive regulation of proline metabolism	http://purl.obolibrary.org/obo/GO_2000216		
HP:0025387	biolink:PhenotypicFeature	Pill-rolling tremor	A type of resting tremor characterized by simultaneous rubbing movements of thumb and index fingers against each other.		hp.json	Pill rolling	http://purl.obolibrary.org/obo/HP_0025387		
HP:0025388	biolink:PhenotypicFeature	Thyroid nodule	A nodular lesion that develops in the thyroid gland. The term "thyroid nodule" refers to any abnormal growth that forms a lump in the thyroid gland.		hp.json		http://purl.obolibrary.org/obo/HP_0025388		
HP:0025389	biolink:PhenotypicFeature	Pulmonary interstitial high-resolution computed tomography abnormality	High-resolution computed tomography (HRCT) can distinguish findings that characterize characterise interstitial lung diseases in a way not possible with other modalities.		hp.json	Pulmonary interstitiatial HRCT abnormality	http://purl.obolibrary.org/obo/HP_0025389		
GO:2000211	biolink:BiologicalProcess	regulation of glutamate metabolic process	Any process that modulates the frequency, rate or extent of glutamate metabolic process.		hp.json	regulation of glutamate metabolism|regulation of glutamic acid metabolism|regulation of glutamic acid metabolic process	http://purl.obolibrary.org/obo/GO_2000211		
PR:000029968	biolink:Protein	somatotropin hormone family member	A protein that is a standalone version of the Hormone_1 domain (Pfam:PF00103). In the immature form, the domain is preceded by a signal peptide.		hp.json	fam:GH1	http://purl.obolibrary.org/obo/PR_000029968		
GO:2000212	biolink:BiologicalProcess	negative regulation of glutamate metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process.		hp.json	negative regulation of glutamic acid metabolic process|negative regulation of glutamate metabolism|negative regulation of glutamic acid metabolism	http://purl.obolibrary.org/obo/GO_2000212		
GO:2000213	biolink:BiologicalProcess	positive regulation of glutamate metabolic process	Any process that activates or increases the frequency, rate or extent of glutamate metabolic process.		hp.json	positive regulation of glutamic acid metabolic process|positive regulation of glutamate metabolism|positive regulation of glutamic acid metabolism	http://purl.obolibrary.org/obo/GO_2000213		
HP:0025380	biolink:PhenotypicFeature	Increased circulating androstenedione concentration	Increased concentration of androstenedione in the blood circulation.		hp.json	Increased serum androstenedione	http://purl.obolibrary.org/obo/HP_0025380		
HP:0025381	biolink:PhenotypicFeature	Anti-pituitary antibody positivity	Circulating antipituitary antibodies (APA) are markers of autoimmune hypophysitis, which may cause deficient pituitary function.		hp.json		http://purl.obolibrary.org/obo/HP_0025381		
HP:0025382	biolink:PhenotypicFeature	Hypodipsia	Reduced fluid intake (drinking) in a clinical situation where the plasma molarity or sodium concentration normally would induce greater fluid intake.		hp.json		http://purl.obolibrary.org/obo/HP_0025382		
HP:0025383	biolink:PhenotypicFeature	Dorsocervical fat pad	An area of fat accumulation at the back of the neck in the form of a hump.		hp.json	Buffalo hump	http://purl.obolibrary.org/obo/HP_0025383		
HP:0025384	biolink:PhenotypicFeature	Diet-resistant subcutaneous adipose tissue	Areas of subcutanous fat tissue that are resistant to (do not respond as expected to) diet, life-style alteration, or bariatric surgery.		hp.json		http://purl.obolibrary.org/obo/HP_0025384		
HP:0025385	biolink:PhenotypicFeature	Diet-resistant subcutaneous adipose tissue below waist	Areas of subcutanous fat tissue below the waist that are resistant to (do not respond as expected to) diet, life-style alteration, or bariatric surgery.		hp.json		http://purl.obolibrary.org/obo/HP_0025385		
HP:0025386	biolink:PhenotypicFeature	Bitemporal hollowing	Depression of profile in both temporal regions.		hp.json		http://purl.obolibrary.org/obo/HP_0025386		
GO:0002067	biolink:BiologicalProcess	glandular epithelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.		hp.json		http://purl.obolibrary.org/obo/GO_0002067		
GO:0002068	biolink:BiologicalProcess	glandular epithelial cell development	The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.		hp.json		http://purl.obolibrary.org/obo/GO_0002068		
GO:0002069	biolink:BiologicalProcess	columnar/cuboidal epithelial cell maturation	The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.		hp.json		http://purl.obolibrary.org/obo/GO_0002069		
GO:0002063	biolink:BiologicalProcess	chondrocyte development	The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.		hp.json		http://purl.obolibrary.org/obo/GO_0002063		
GO:0002064	biolink:BiologicalProcess	epithelial cell development	The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.		hp.json		http://purl.obolibrary.org/obo/GO_0002064		
HP:0001327	biolink:PhenotypicFeature	Photosensitive myoclonic seizure	Generalised myoclonic seizure provoked by flashing or flickering light.	UMLS:C4025791	hp.json	Photomyoclonic seizures|Photomyoclonic seizure|Photically induced myoclonic seizure	http://purl.obolibrary.org/obo/HP_0001327		
GO:0002065	biolink:BiologicalProcess	columnar/cuboidal epithelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.		hp.json		http://purl.obolibrary.org/obo/GO_0002065		
HP:0001328	biolink:PhenotypicFeature	Specific learning disability	Impairment of certain skills such as reading or writing, coordination, self-control, or attention that interfere with the ability to learn. The impairment is not related to a global deficiency of intelligence.	UMLS:C4025790	hp.json		http://purl.obolibrary.org/obo/HP_0001328		
HP:0003989	biolink:PhenotypicFeature	Notched ulna		UMLS:C4025462	hp.json		http://purl.obolibrary.org/obo/HP_0003989		
GO:0002066	biolink:BiologicalProcess	columnar/cuboidal epithelial cell development	The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.		hp.json		http://purl.obolibrary.org/obo/GO_0002066		
GO:0002062	biolink:BiologicalProcess	chondrocyte differentiation	The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.		hp.json		http://purl.obolibrary.org/obo/GO_0002062		
GO:0014049	biolink:BiologicalProcess	positive regulation of glutamate secretion	Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate.		hp.json	upregulation of glutamate secretion|up-regulation of glutamate secretion|up regulation of glutamate secretion|activation of glutamate secretion|stimulation of glutamate secretion	http://purl.obolibrary.org/obo/GO_0014049		
HP:0001321	biolink:PhenotypicFeature	Cerebellar hypoplasia	Cerebellar hypoplasia is a descriptive term implying a cerebellum with a reduced volume, but a normal shape and is stable over time.	UMLS:C0266470|MSH:C562568|SNOMEDCT_US:16026008	hp.json	Underdeveloped cerebellum|Small cerebellum|Congenital cerebellar hypoplasia|Hypoplastic cerebellum|Hypoplasia of cerebellum	http://purl.obolibrary.org/obo/HP_0001321		
HP:0003984	biolink:PhenotypicFeature	Posteriorly dislocated ulna		UMLS:C4025465	hp.json		http://purl.obolibrary.org/obo/HP_0003984		
HP:0001322	biolink:PhenotypicFeature	obsolete Brain very small			hp.json		http://purl.obolibrary.org/obo/HP_0001322		
GO:0014048	biolink:BiologicalProcess	regulation of glutamate secretion	Any process that modulates the frequency, rate or extent of the controlled release of glutamate.		hp.json		http://purl.obolibrary.org/obo/GO_0014048		
HP:0003982	biolink:PhenotypicFeature	Aplasia of the ulna	Missing ulna bone associated with congenital failure of development.	UMLS:C2678397	hp.json	Absent ossification/absent ulna|Absent ulna|Absent ulnae	http://purl.obolibrary.org/obo/HP_0003982		hposlim_core
GO:0014047	biolink:BiologicalProcess	glutamate secretion	The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0014047		
HP:0001320	biolink:PhenotypicFeature	Cerebellar vermis hypoplasia	Underdevelopment of the vermis of cerebellum.	UMLS:C1840379	hp.json	Hypoplastic cerebellar vermis|Cerebellar vermal hypoplasia|Hypoplasia of the cerebellar vermis	http://purl.obolibrary.org/obo/HP_0001320		
GO:0014046	biolink:BiologicalProcess	dopamine secretion	The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone.		hp.json		http://purl.obolibrary.org/obo/GO_0014046		
HP:0003981	biolink:PhenotypicFeature	Broad radius	Increased width of the radius.	UMLS:C4021698	hp.json	Wide radius	http://purl.obolibrary.org/obo/HP_0003981		
HP:0003988	biolink:PhenotypicFeature	Long ulna	Increased length of the ulna.	UMLS:C1848108	hp.json	Disproportionately long ulnae	http://purl.obolibrary.org/obo/HP_0003988		hposlim_core
HP:0001325	biolink:PhenotypicFeature	Hypoglycemic coma		UMLS:C0020617|SNOMEDCT_US:267384006	hp.json	Hypoglycaemic coma|Coma caused by low blood sugar|Loss of consciousness due to hypoglycemia|Coma, hypoglycemic	http://purl.obolibrary.org/obo/HP_0001325		
HP:0001326	biolink:PhenotypicFeature	EEG with irregular generalized spike and wave complexes	EEG shows spikes (<80 ms) and waves, which are recorded over the entire scalp and do not have a specific frequency.	UMLS:C4025792	hp.json	EEG with irregular generalised spike and wave complexes	http://purl.obolibrary.org/obo/HP_0001326		
HP:0003987	biolink:PhenotypicFeature	Fractured ulna		SNOMEDCT_US:54556006|UMLS:C0041601|MSH:D014458	hp.json		http://purl.obolibrary.org/obo/HP_0003987		
HP:0003986	biolink:PhenotypicFeature	Exostoses of the radius		UMLS:C4025463	hp.json		http://purl.obolibrary.org/obo/HP_0003986		
HP:0001324	biolink:PhenotypicFeature	Muscle weakness	Reduced strength of muscles.	SNOMEDCT_US:26544005|MSH:D018908|UMLS:C0151786	hp.json	Muscular weakness|Muscle weakness	http://purl.obolibrary.org/obo/HP_0001324		
HP:0003985	biolink:PhenotypicFeature	Exostoses of the ulna		UMLS:C4025464	hp.json		http://purl.obolibrary.org/obo/HP_0003985		
GO:0014041	biolink:BiologicalProcess	regulation of neuron maturation	Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change.		hp.json		http://purl.obolibrary.org/obo/GO_0014041		
GO:0014040	biolink:BiologicalProcess	positive regulation of Schwann cell differentiation	Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation.		hp.json	upregulation of Schwann cell differentiation|up regulation of Schwann cell differentiation|stimulation of Schwann cell differentiation|up-regulation of Schwann cell differentiation|activation of Schwann cell differentiation	http://purl.obolibrary.org/obo/GO_0014040		
HP:0003980	biolink:PhenotypicFeature	Pseudarthrosis of the radius		UMLS:C4025466	hp.json		http://purl.obolibrary.org/obo/HP_0003980		
GO:0014044	biolink:BiologicalProcess	Schwann cell development	The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.		hp.json		http://purl.obolibrary.org/obo/GO_0014044		
GO:0014043	biolink:BiologicalProcess	negative regulation of neuron maturation	Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation.		hp.json	down-regulation of neuron maturation|down regulation of neuron maturation|inhibition of neuron maturation|downregulation of neuron maturation	http://purl.obolibrary.org/obo/GO_0014043		
GO:0014042	biolink:BiologicalProcess	positive regulation of neuron maturation	Any process that activates or increases the frequency, rate or extent of neuron maturation.		hp.json	stimulation of neuron maturation|upregulation of neuron maturation|up-regulation of neuron maturation|up regulation of neuron maturation|activation of neuron maturation	http://purl.obolibrary.org/obo/GO_0014042		
HP:0001338	biolink:PhenotypicFeature	Partial agenesis of the corpus callosum	A partial failure of the development of the corpus callosum.	UMLS:C0431368|MSH:C536111|UMLS:C1857278|SNOMEDCT_US:253140003	hp.json	Partial-total agenesis of corpus callosum|Partial or complete agenesis of corpus callosum|Corpus callosum agenesis, partial|Partial or complete agenesis of the corpus callosum|Partial corpus callosum agenesis|Partial agenesis of corpus callosum|Partial to complete agenesis of corpus callosum	http://purl.obolibrary.org/obo/HP_0001338		
HP:0001339	biolink:PhenotypicFeature	Lissencephaly	A spectrum of malformations of cortical development caused by insufficient neuronal migration that subsumes the terms agyria, pachygyria and subcortical band heterotopia. See also neuropathological definitions for 2-, 3-, and 4-layered lissencephaly.	UMLS:C0266463|MSH:D054082|SNOMEDCT_US:204036008|UMLS:C1879312	hp.json	Fewer or absent grooves in brain	http://purl.obolibrary.org/obo/HP_0001339		
GO:0002070	biolink:BiologicalProcess	epithelial cell maturation	The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.		hp.json		http://purl.obolibrary.org/obo/GO_0002070		
GO:0002071	biolink:BiologicalProcess	glandular epithelial cell maturation	The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.		hp.json		http://purl.obolibrary.org/obo/GO_0002071		
GO:0002072	biolink:BiologicalProcess	optic cup morphogenesis involved in camera-type eye development	The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.		hp.json	optic cup morphogenesis involved in camera-style eye development	http://purl.obolibrary.org/obo/GO_0002072		
HGNC:2295	biolink:Gene	CP (human)	A protein coding gene CP in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2295		
HP:0001332	biolink:PhenotypicFeature	Dystonia	An abnormally increased muscular tone that causes fixed abnormal postures. There is a slow, intermittent twisting motion that leads to exaggerated turning and posture of the extremities and trunk.	UMLS:C0013421|UMLS:C4020871|MSH:D004421	hp.json	Dystonic disease|Dystonic movements	http://purl.obolibrary.org/obo/HP_0001332		
HP:0003995	biolink:PhenotypicFeature	Abnormality of the radial head		UMLS:C4021696	hp.json	Deformity of radial heads	http://purl.obolibrary.org/obo/HP_0003995		
HP:0003994	biolink:PhenotypicFeature	Dislocated wrist	An injury of the wrist with displacement of any of the eight carpal bones.	SNOMEDCT_US:125618007|MEDDRA:10013184|UMLS:C0159941	hp.json	Dislocated wrist|Dislocations of the wrists	http://purl.obolibrary.org/obo/HP_0003994		
GO:0014059	biolink:BiologicalProcess	regulation of dopamine secretion	Any process that modulates the frequency, rate or extent of the regulated release of dopamine.		hp.json		http://purl.obolibrary.org/obo/GO_0014059		
HP:0003993	biolink:PhenotypicFeature	Broad ulna	Increased width of the ulna.	UMLS:C4025460|UMLS:C4020692	hp.json	Wide ulna	http://purl.obolibrary.org/obo/HP_0003993		
HP:0003992	biolink:PhenotypicFeature	Slender ulna	Reduction in diameter of the ulna.	UMLS:C1968814	hp.json		http://purl.obolibrary.org/obo/HP_0003992		
HP:0001331	biolink:PhenotypicFeature	Absent septum pellucidum	Absence of the septum pellucidum.	MSH:C535562|UMLS:C0431371|SNOMEDCT_US:253143001	hp.json	Agenesis of the septum pellucidum|Missing septum pellucidum|Absence of the septum pellucidum|Absence of septum pellucidum	http://purl.obolibrary.org/obo/HP_0001331		
HP:0003999	biolink:PhenotypicFeature	Abnormality of radial epiphyses		UMLS:C4021694	hp.json	Abnormality of radial epiphyseal plates	http://purl.obolibrary.org/obo/HP_0003999		
HP:0001336	biolink:PhenotypicFeature	Myoclonus	Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements.	UMLS:C1854302|SNOMEDCT_US:127324008|UMLS:C0027066|SNOMEDCT_US:17450006|MSH:D009207	hp.json	Jerking|Involuntary jerking movements|Myoclonic jerks	http://purl.obolibrary.org/obo/HP_0001336		
HP:0001337	biolink:PhenotypicFeature	Tremor	An unintentional, oscillating to-and-fro muscle movement about a joint axis.	UMLS:C0040822|MSH:D014202|SNOMEDCT_US:26079004	hp.json	Tremors|Tremor	http://purl.obolibrary.org/obo/HP_0001337		
HP:0003998	biolink:PhenotypicFeature	Constricted radial neck		UMLS:C4025458	hp.json		http://purl.obolibrary.org/obo/HP_0003998		
HP:0003997	biolink:PhenotypicFeature	Hypoplastic radial head		UMLS:C4021695	hp.json	Small radial head	http://purl.obolibrary.org/obo/HP_0003997		
HP:0001334	biolink:PhenotypicFeature	Communicating hydrocephalus	A form of hydrocephalus in which there is no visible obstruction to the flow of the cerebrospinal fluid between the ventricles and subarachnoid space.	SNOMEDCT_US:271569006|MSH:D006849|UMLS:C0009451	hp.json		http://purl.obolibrary.org/obo/HP_0001334		
HP:0001335	biolink:PhenotypicFeature	Bimanual synkinesia	Involuntary movements of one hand that accompany and mirror intentional movements of the opposite hand.	UMLS:C0454455|SNOMEDCT_US:229247004	hp.json	Mirror hand movements|Hand mirror movements|Mirror movements	http://purl.obolibrary.org/obo/HP_0001335		
HP:0003996	biolink:PhenotypicFeature	Flattened radial head		UMLS:C4025459	hp.json		http://purl.obolibrary.org/obo/HP_0003996		
GO:0014050	biolink:BiologicalProcess	negative regulation of glutamate secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate.		hp.json	inhibition of glutamate secretion|downregulation of glutamate secretion|down-regulation of glutamate secretion|down regulation of glutamate secretion	http://purl.obolibrary.org/obo/GO_0014050		
HP:0003991	biolink:PhenotypicFeature	Osteosclerosis of the ulna	Osteosclerosis (increased density related to increased bone mass) of the ulna.	UMLS:C4021697	hp.json	Sclerotic ulna	http://purl.obolibrary.org/obo/HP_0003991		
HP:0003990	biolink:PhenotypicFeature	Pointed ulna		UMLS:C4025461	hp.json		http://purl.obolibrary.org/obo/HP_0003990		
HP:0001308	biolink:PhenotypicFeature	Tongue fasciculations	Fasciculations or fibrillation affecting the tongue muscle.	MSH:D005207|SNOMEDCT_US:249878001|UMLS:C0239548	hp.json	Lingual twitching|Twitching of the tongue|Tongue fasciculation|Tongue fasciculations/fibrillations|Lingual fasciculations|Tongue twitching|Lingual fibrillations	http://purl.obolibrary.org/obo/HP_0001308		
HP:0003969	biolink:PhenotypicFeature	Slender forearm bones		UMLS:C4025471	hp.json		http://purl.obolibrary.org/obo/HP_0003969		
HP:0001305	biolink:PhenotypicFeature	Dandy-Walker malformation	A congenital brain malformation typically characterized by incomplete formation of the cerebellar vermis, dilation of the fourth ventricle, and enlargement of the posterior fossa. In layman's terms, Dandy Walker malformation is a cyst in the cerebellum (typically symmetrical) that is involved with the fourth ventricle. This may interfere with the ability to drain cerebrospinal fluid from the brain, resulting in hydrocephalus. Dandy Walker cysts are formed during early embryonic development, while the brain forms. The cyst in the cerebellum typically has several blood vessels running through it connecting to the brain, thereby prohibiting surgical removal.	UMLS:C0010964|MSH:D003616|SNOMEDCT_US:14447001	hp.json	Dandy-walker anomaly|Dandy-Walker cyst	http://purl.obolibrary.org/obo/HP_0001305		
HP:0003967	biolink:PhenotypicFeature	Sclerotic forearm bones		UMLS:C4025472	hp.json	Increased bone density of forearm bones	http://purl.obolibrary.org/obo/HP_0003967		
HP:0001300	biolink:PhenotypicFeature	Parkinsonism	Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait.	UMLS:C0242422|MSH:D020734|SNOMEDCT_US:32798002	hp.json	Parkinsonian disease	http://purl.obolibrary.org/obo/HP_0001300		
HP:0003961	biolink:PhenotypicFeature	Fractured forearm bones	Bone fracture in the radius, ulna, or wrist.	UMLS:C4025477	hp.json	Fractured forearm bones|Fracture of the forearm|Broken forearm	http://purl.obolibrary.org/obo/HP_0003961		
HP:0003960	biolink:PhenotypicFeature	Exostoses of the forearm bones		UMLS:C4025478	hp.json		http://purl.obolibrary.org/obo/HP_0003960		
GO:0014025	biolink:BiologicalProcess	neural keel formation	The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts.		hp.json		http://purl.obolibrary.org/obo/GO_0014025		
HP:0003966	biolink:PhenotypicFeature	Sclerotic foci in forearm bones		UMLS:C4025473	hp.json		http://purl.obolibrary.org/obo/HP_0003966		
HP:0001304	biolink:PhenotypicFeature	Torsion dystonia	Sustained involuntary muscle contractions that produce twisting and repetitive movements of the body.	MSH:D004422|UMLS:C0013423|SNOMEDCT_US:22451001|SNOMEDCT_US:431034009	hp.json	Dystonia musculorum deformans	http://purl.obolibrary.org/obo/HP_0001304		
HP:0003965	biolink:PhenotypicFeature	Pseudarthrosis of the forearm bones		UMLS:C4025474	hp.json		http://purl.obolibrary.org/obo/HP_0003965		
GO:0014029	biolink:BiologicalProcess	neural crest formation	The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.		hp.json		http://purl.obolibrary.org/obo/GO_0014029		
HP:0001301	biolink:PhenotypicFeature	Chronic sensorineural polyneuropathy		UMLS:C4025794	hp.json		http://purl.obolibrary.org/obo/HP_0001301		
HP:0003964	biolink:PhenotypicFeature	Osteoporotic forearm bones		UMLS:C4025475	hp.json		http://purl.obolibrary.org/obo/HP_0003964		
GO:0014028	biolink:BiologicalProcess	notochord formation	The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.		hp.json		http://purl.obolibrary.org/obo/GO_0014028		
HP:0003963	biolink:PhenotypicFeature	Lytic defects of the forearm bones		UMLS:C4025476	hp.json		http://purl.obolibrary.org/obo/HP_0003963		
HP:0001302	biolink:PhenotypicFeature	Pachygyria	Pachygyria is a malformation of cortical development with abnormally wide gyri with sulci 1,5-3 cm apart and abnormally thick cortex measuring more than 5 mm (radiological definition). See also neuropathological definitions for 2-, 3-, and 4-layered lissencephaly.	SNOMEDCT_US:23024003|MSH:D054082|UMLS:C0266483	hp.json	Cerebral pachygyria|Fewer and broader ridges in brain	http://purl.obolibrary.org/obo/HP_0001302		
GO:0014023	biolink:BiologicalProcess	neural rod formation	The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts.		hp.json		http://purl.obolibrary.org/obo/GO_0014023		
GO:0014020	biolink:BiologicalProcess	primary neural tube formation	The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.		hp.json	primary neurulation|neural rod cavitation|primary neural tube morphogenesis	http://purl.obolibrary.org/obo/GO_0014020		
GO:0002052	biolink:BiologicalProcess	positive regulation of neuroblast proliferation	Any process that activates or increases the rate of neuroblast proliferation.		hp.json	upregulation of neuroblast proliferation|up regulation of neuroblast proliferation|stimulation of neuroblast proliferation|up-regulation of neuroblast proliferation|activation of neuroblast proliferation	http://purl.obolibrary.org/obo/GO_0002052		
GO:0002053	biolink:BiologicalProcess	positive regulation of mesenchymal cell proliferation	The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.		hp.json	activation of mesenchymal cell proliferation|upregulation of mesenchymal cell proliferation|up regulation of mesenchymal cell proliferation|stimulation of mesenchymal cell proliferation|up-regulation of mesenchymal cell proliferation	http://purl.obolibrary.org/obo/GO_0002053		
HP:0001319	biolink:PhenotypicFeature	Neonatal hypotonia	Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period.	SNOMEDCT_US:205294008|UMLS:C2267233|MSH:D009123	hp.json	Congenital hypotonia|Hypotonia, in neonatal onset|Hypotonia, neonatal|Low muscle tone, in neonatal onset	http://purl.obolibrary.org/obo/HP_0001319		
GO:0002054	biolink:MolecularActivity	nucleobase binding	Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases.		hp.json		http://purl.obolibrary.org/obo/GO_0002054		goslim_pir
HP:0003979	biolink:PhenotypicFeature	Lytic defects of the radius		UMLS:C4021841	hp.json		http://purl.obolibrary.org/obo/HP_0003979		
HP:0003978	biolink:PhenotypicFeature	Fractured radius		SNOMEDCT_US:12676007|UMLS:C0034628|MSH:D011885	hp.json		http://purl.obolibrary.org/obo/HP_0003978		
HP:0001317	biolink:PhenotypicFeature	Abnormal cerebellum morphology	Any structural abnormality of the cerebellum.	UMLS:C1866129|UMLS:C0742038	hp.json	Cerebellar signs|Cerebellar abnormality|Abnormality of the cerebellum|Cerebellar abnormalities|Cerebellar anomaly	http://purl.obolibrary.org/obo/HP_0001317		
HP:0003973	biolink:PhenotypicFeature	Wide radioulnar joints		UMLS:C4021699	hp.json	Broad radioulnar joints	http://purl.obolibrary.org/obo/HP_0003973		
GO:0014038	biolink:BiologicalProcess	regulation of Schwann cell differentiation	Any process that modulates the frequency, rate or extent of Schwann cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0014038		
HP:0001310	biolink:PhenotypicFeature	Dysmetria	A type of ataxia characterized by the inability to carry out movements with the correct range and motion across the plane of more than one joint related to incorrect estimation of the distances required for targeted movements.	SNOMEDCT_US:32566006|UMLS:C0234162|MSH:D002524	hp.json	Abnormal finger-nose-finger test|Lack of coordination of movement|Abnormal finger chase test	http://purl.obolibrary.org/obo/HP_0001310		
HP:0001311	biolink:PhenotypicFeature	Abnormal nervous system electrophysiology	An abnormality of the function of the electrical signals with which nerve cells communicate with each other or with muscles as measured by electrophysiological investigations.	UMLS:C4021781	hp.json	Neurophysiologic abnormality|Neurophysiologic abnormalities	http://purl.obolibrary.org/obo/HP_0001311		
GO:0014037	biolink:BiologicalProcess	Schwann cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.		hp.json		http://purl.obolibrary.org/obo/GO_0014037		
HP:0003971	biolink:PhenotypicFeature	Broad forearm bones	Abnormally wide bone of the skeleton of forearm.	UMLS:C4021700	hp.json	Wide forearm bones|Broad forearm bones	http://purl.obolibrary.org/obo/HP_0003971		
HP:0003970	biolink:PhenotypicFeature	Undermodelled forearm bones		UMLS:C4025470	hp.json		http://purl.obolibrary.org/obo/HP_0003970		
HP:0003977	biolink:PhenotypicFeature	Deformed radius		UMLS:C4025467	hp.json		http://purl.obolibrary.org/obo/HP_0003977		
HP:0001315	biolink:PhenotypicFeature	Reduced tendon reflexes	Diminution of tendon reflexes, which is an invariable sign of peripheral nerve disease.	UMLS:C1866934	hp.json	Absent or decreased deep tendon reflexes|Diminished deep tendon reflexes|Decreased/absent deep tendon reflexes|Decreased to absent deep tendon reflexes|Hypoactive to absent deep tendon reflexes|Diminished or absent deep tendon reflexes|Decreased deep tendon reflexes|Decreased tendon reflexes|Diminished or absent tendon reflexes|Reduced/absent deep tendon reflexes|Depressed tendon reflexes|Weak or absent deep tendon reflexes|Impaired tendon reflexes	http://purl.obolibrary.org/obo/HP_0001315		
HP:0003976	biolink:PhenotypicFeature	Constricted radius		UMLS:C4025468	hp.json		http://purl.obolibrary.org/obo/HP_0003976		
HP:0001312	biolink:PhenotypicFeature	Giant somatosensory evoked potentials	An abnormal enlargement (i.e. increase in measured voltage) of somatosensory evoked potentials.	UMLS:C3806961	hp.json	Giant SEPS	http://purl.obolibrary.org/obo/HP_0001312		
HP:0003975	biolink:PhenotypicFeature	obsolete Chevron-shaped/cone-shaped radius			hp.json		http://purl.obolibrary.org/obo/HP_0003975		
HP:0003974	biolink:PhenotypicFeature	Absent radius	Missing radius bone associated with congenital failure of development.	UMLS:C1838608|UMLS:C1405984|UMLS:C1849314	hp.json	absence of radius and ulna|Missing outer large bone of forearm|Radial aplasia|Aplasia of the radius|Absent ossification/absence of radius	http://purl.obolibrary.org/obo/HP_0003974		hposlim_core
GO:0014039	biolink:BiologicalProcess	negative regulation of Schwann cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation.		hp.json	downregulation of Schwann cell differentiation|down regulation of Schwann cell differentiation|inhibition of Schwann cell differentiation|down-regulation of Schwann cell differentiation	http://purl.obolibrary.org/obo/GO_0014039		
GO:0014033	biolink:BiologicalProcess	neural crest cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.		hp.json		http://purl.obolibrary.org/obo/GO_0014033		
GO:0014032	biolink:BiologicalProcess	neural crest cell development	The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0014032		
GO:0014031	biolink:BiologicalProcess	mesenchymal cell development	The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0014031		
GO:0002027	biolink:BiologicalProcess	regulation of heart rate	Any process that modulates the frequency or rate of heart contraction.		hp.json	regulation of rate of heart contraction|cardiac chronotropy|regulation of heart contraction rate	http://purl.obolibrary.org/obo/GO_0002027		
GO:2000269	biolink:BiologicalProcess	regulation of fibroblast apoptotic process	Any process that modulates the frequency, rate or extent of fibroblast apoptotic process.		hp.json	regulation of fibroblast apoptosis	http://purl.obolibrary.org/obo/GO_2000269		
HP:0025332	biolink:PhenotypicFeature	Abnormality of foot cortical bone	An anomaly of the outer shell (cortex) of a foot bone.		hp.json	Abnormality of the cortex of foot bones	http://purl.obolibrary.org/obo/HP_0025332		
GO:2000261	biolink:BiologicalProcess	negative regulation of blood coagulation, common pathway	Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway.		hp.json		http://purl.obolibrary.org/obo/GO_2000261		
HP:0025333	biolink:PhenotypicFeature	Cortical thinning of foot bones	A reduction in the thickness of the outer shell (cortex) of foot bones.		hp.json		http://purl.obolibrary.org/obo/HP_0025333		
GO:2000262	biolink:BiologicalProcess	positive regulation of blood coagulation, common pathway	Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway.		hp.json		http://purl.obolibrary.org/obo/GO_2000262		
HP:0001363	biolink:PhenotypicFeature	Craniosynostosis	Craniosynostosis refers to the premature closure of the cranial sutures. Primary craniosynostosis refers to the closure of one or more sutures due to abnormalities in skull development, and secondary craniosynostosis results from failure of brain growth.	SNOMEDCT_US:57219006|UMLS:C0010278|MSH:D003398|UMLS:C0235942|Fyler:4336	hp.json	Craniostenosis|Premature fontanel closure|Cranial suture synostosis|Premature suture closure|Early fusion of cranial sutures|Deformity of the skull|Craniosyostosis|Premature closure of cranial sutures	http://purl.obolibrary.org/obo/HP_0001363		hposlim_core
HP:0025334	biolink:PhenotypicFeature	Triggered by emotion	Applies to a sign or symptom that is provoked or brought about by a strong spontaneously arising mental state, reaction or feeling (emotion).		hp.json	Emotion triggered symptoms	http://purl.obolibrary.org/obo/HP_0025334		
GO:2000263	biolink:BiologicalProcess	regulation of blood coagulation, extrinsic pathway	Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway.		hp.json		http://purl.obolibrary.org/obo/GO_2000263		
GO:0014003	biolink:BiologicalProcess	oligodendrocyte development	The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.		hp.json	oligodendrocyte cell development	http://purl.obolibrary.org/obo/GO_0014003		
HP:0025335	biolink:PhenotypicFeature	Delayed ability to stand	A failure to achieve the ability to stand up at an appropriate developmental stage. Most children begin to walk alone at 11 to 15 months of age. On average, children can stand while holding on at the age of 9 to 10 months, can pull up to stand and walk with one hand being held at 12 months, and can stand alone and walk well at 18 months.		hp.json		http://purl.obolibrary.org/obo/HP_0025335		
GO:2000264	biolink:BiologicalProcess	negative regulation of blood coagulation, extrinsic pathway	Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway.		hp.json		http://purl.obolibrary.org/obo/GO_2000264		
GO:0014009	biolink:BiologicalProcess	glial cell proliferation	The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others.		hp.json	glia proliferation	http://purl.obolibrary.org/obo/GO_0014009		
HP:0001369	biolink:PhenotypicFeature	Arthritis	Inflammation of a joint.	SNOMEDCT_US:3723001|MSH:D001168|UMLS:C0003864	hp.json	Joint inflammation|Arthritis	http://purl.obolibrary.org/obo/HP_0001369		
HP:0025336	biolink:PhenotypicFeature	Delayed ability to sit	A failure to achieve the ability to sit at an appropriate developmental stage. Most children sit with support at 6 months of age and sit steadily without support at 9 months of age.		hp.json		http://purl.obolibrary.org/obo/HP_0025336		
GO:2000265	biolink:BiologicalProcess	positive regulation of blood coagulation, extrinsic pathway	Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway.		hp.json		http://purl.obolibrary.org/obo/GO_2000265		
HP:0025337	biolink:PhenotypicFeature	Red eye	A reddish appearance over the white part (sclera) of the eye ranging from a few enlarged blood vessels appearing as wiggly lines over the sclera to a bright red color completely covering to sclera.		hp.json	Red eye|Red eyes	http://purl.obolibrary.org/obo/HP_0025337		
GO:2000266	biolink:BiologicalProcess	regulation of blood coagulation, intrinsic pathway	Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway.		hp.json		http://purl.obolibrary.org/obo/GO_2000266		
HP:0001367	biolink:PhenotypicFeature	Abnormal joint morphology	An abnormal structure or form of the joints, i.e., one or more of the articulations where two bones join.	UMLS:C0240083|UMLS:C0022408|MSH:D007592|SNOMEDCT_US:399269003	hp.json	Abnormal shape of joints|Abnormality of the joints|Anomaly of the joints|Joint disease	http://purl.obolibrary.org/obo/HP_0001367		
GO:2000267	biolink:BiologicalProcess	negative regulation of blood coagulation, intrinsic pathway	Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway.		hp.json		http://purl.obolibrary.org/obo/GO_2000267		
HP:0025338	biolink:PhenotypicFeature	Circumlimbal hyperemia	A ring of redness at the limbus of the eye, the border between the cornea and the sclera.		hp.json	Ciliary limbus|Circumlimbal hyperaemia	http://purl.obolibrary.org/obo/HP_0025338		
GO:0016667	biolink:MolecularActivity	oxidoreductase activity, acting on a sulfur group of donors	Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	EC:1.8.-.-|Reactome:R-HSA-2213240	hp.json	oxidoreductase activity, acting on sulfur group of donors, other acceptors|oxidoreductase activity, acting on sulphur group of donors	http://purl.obolibrary.org/obo/GO_0016667		
HP:0025339	biolink:PhenotypicFeature	Superficial episcleral hyperemia	Prominence of blood vessels of the superficial episcleral tissues.		hp.json	Superficial episcleral hypaeremia	http://purl.obolibrary.org/obo/HP_0025339		
GO:2000268	biolink:BiologicalProcess	positive regulation of blood coagulation, intrinsic pathway	Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway.		hp.json		http://purl.obolibrary.org/obo/GO_2000268		
HP:0001361	biolink:PhenotypicFeature	Nystagmus-induced head nodding	Head movements associated with nystagmus, that may represent an attempt to compensate for the involuntary eye movements and to improve vision.	UMLS:C4025788	hp.json		http://purl.obolibrary.org/obo/HP_0001361		
HP:0001362	biolink:PhenotypicFeature	Calvarial skull defect	A localized defect in the bone of the skull resulting from abnormal embryological development. The defect is covered by normal skin. In some cases, skull x-rays have shown underlying lytic bone lesions which have closed before the age of one year.	UMLS:C4280595|UMLS:C4025787|UMLS:C4280596	hp.json	Cranial defect|Skull defect|Calvarial defect	http://purl.obolibrary.org/obo/HP_0001362		
HP:0025330	biolink:PhenotypicFeature	Downgaze palsy	A limitation of the ability to direct one's gaze below the horizontal meridian.		hp.json	Downgaze paresis|Supranuclear downgaze palsy	http://purl.obolibrary.org/obo/HP_0025330		
HP:0025331	biolink:PhenotypicFeature	Upgaze palsy	A limitation of the ability to direct one's gaze above the horizontal meridian.		hp.json	Upgaze paresis|Supranuclear upgaze palsy	http://purl.obolibrary.org/obo/HP_0025331		
GO:2000260	biolink:BiologicalProcess	regulation of blood coagulation, common pathway	Any process that modulates the frequency, rate or extent of blood coagulation, common pathway.		hp.json		http://purl.obolibrary.org/obo/GO_2000260		
HP:0001360	biolink:PhenotypicFeature	Holoprosencephaly	Holoprosencephaly is a structural anomaly of the brain in which the developing forebrain fails to divide into two separate hemispheres and ventricles.	UMLS:C0079541|Fyler:4338|SNOMEDCT_US:30915001|MSH:D016142	hp.json	Single brain ventricle	http://purl.obolibrary.org/obo/HP_0001360		
HP:0025329	biolink:PhenotypicFeature	Anti-glutamic acid decarboxylase antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against glutamic acid decarboxylase.		hp.json	Anti-GAD antibody positivity	http://purl.obolibrary.org/obo/HP_0025329		
HP:0025321	biolink:PhenotypicFeature	Copper accumulation in liver	An anomalous build up of copper (Cu) in the liver.		hp.json	Liver copper accumulation	http://purl.obolibrary.org/obo/HP_0025321		
GO:0014016	biolink:BiologicalProcess	neuroblast differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts.		hp.json		http://purl.obolibrary.org/obo/GO_0014016		
GO:2000272	biolink:BiologicalProcess	negative regulation of signaling receptor activity	Any process that stops, prevents or reduces the frequency, rate or extent of a signaling receptor activity.		hp.json	negative regulation of signalling receptor activity|negative regulation of receptor activity	http://purl.obolibrary.org/obo/GO_2000272		
HP:0001376	biolink:PhenotypicFeature	Limitation of joint mobility	A reduction in the freedom of movement of one or more joints.	UMLS:C1857108	hp.json	Decreased joint mobility|Decreased mobility of joints|Limited joint mobility|Limitation of joint mobility|Limited joint motion	http://purl.obolibrary.org/obo/HP_0001376		
HP:0001377	biolink:PhenotypicFeature	Limited elbow extension	Limited ability to straighten the arm at the elbow joint.	UMLS:C1867103	hp.json	Limitation of elbow extension|Restricted elbow extension|Limited elbow extension|Elbow limited extension|Limited forearm extension|Decreased elbow extension|Limited extension at elbows	http://purl.obolibrary.org/obo/HP_0001377		hposlim_core
GO:0014015	biolink:BiologicalProcess	positive regulation of gliogenesis	Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia.		hp.json	stimulation of gliogenesis|upregulation of gliogenesis|up-regulation of gliogenesis|up regulation of gliogenesis|activation of gliogenesis	http://purl.obolibrary.org/obo/GO_0014015		
GO:2000273	biolink:BiologicalProcess	positive regulation of signaling receptor activity	Any process that activates or increases the frequency, rate or extent of signaling receptor activity.		hp.json	positive regulation of signalling receptor activity	http://purl.obolibrary.org/obo/GO_2000273		
HP:0025322	biolink:PhenotypicFeature	Venous occlusion	Blockage of venous return (flow of blood from the periphery back towards the right atrium) in a vein.		hp.json		http://purl.obolibrary.org/obo/HP_0025322		
GO:0014014	biolink:BiologicalProcess	negative regulation of gliogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia.		hp.json	down-regulation of gliogenesis|down regulation of gliogenesis|inhibition of gliogenesis|downregulation of gliogenesis	http://purl.obolibrary.org/obo/GO_0014014		
HP:0001374	biolink:PhenotypicFeature	Congenital hip dislocation		SNOMEDCT_US:48334007|SNOMEDCT_US:52781008|UMLS:C0019555|MSH:D006618	hp.json	Congenital dislocation of the hips|Congenital dislocation of the hip|Congenital hip dislocations|Dislocated hip since birth|Congenital hip anomaly	http://purl.obolibrary.org/obo/HP_0001374		
HP:0025323	biolink:PhenotypicFeature	Abnormal arterial physiology	An anomaly of arterial function.		hp.json		http://purl.obolibrary.org/obo/HP_0025323		
GO:0014013	biolink:BiologicalProcess	regulation of gliogenesis	Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia.		hp.json		http://purl.obolibrary.org/obo/GO_0014013		
HP:0025324	biolink:PhenotypicFeature	Arterial occlusion	Blockage of blood flow through an artery.		hp.json		http://purl.obolibrary.org/obo/HP_0025324		
HP:0025325	biolink:PhenotypicFeature	Sparse medial eyebrow	Decreased density/number and/or decreased diameter of medial eyebrow hairs.		hp.json	Medial thinning of eyebrow	http://purl.obolibrary.org/obo/HP_0025325		
HP:0025326	biolink:PhenotypicFeature	Retinal arterial occlusion	Blockage of the retinal artery, generally associated with interruption of blood flow and oxygen delivery to the retina.		hp.json	Retinal artery occlusion	http://purl.obolibrary.org/obo/HP_0025326		
GO:0014019	biolink:BiologicalProcess	neuroblast development	The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron.		hp.json		http://purl.obolibrary.org/obo/GO_0014019		
HP:0025327	biolink:PhenotypicFeature	Decreased renal parenchymal thickness	Reduced dimension of the solid part of the kidney (parenchyma, the renal cortex and medulla) as measured from the collecting system (renal calyces and pelvis) to the border of the kidney. This measurement can be performed by measuring the thickness of the parenchyma in computed tomography scans.		hp.json		http://purl.obolibrary.org/obo/HP_0025327		
HP:0025328	biolink:PhenotypicFeature	Antepartum hemorrhage	Significant maternal hemorrhage/bleed in the second half of pregnancy and prior to the birth of the baby.		hp.json	Prepartum hemorrhage|Prepartum haemorrhage|Antepartum haemorrhage	http://purl.obolibrary.org/obo/HP_0025328		
HP:0001379	biolink:PhenotypicFeature	obsolete Degenerative joint disease			hp.json		http://purl.obolibrary.org/obo/HP_0001379		
HP:0001373	biolink:PhenotypicFeature	Joint dislocation	Displacement or malalignment of joints.	MSH:D004204|SNOMEDCT_US:108367008|UMLS:C0012691|SNOMEDCT_US:87642003	hp.json	Joint dislocation|Joint dislocations	http://purl.obolibrary.org/obo/HP_0001373		
CHEBI:137982	biolink:ChemicalSubstance	tertiary ammonium ion	An organic cation obtained by protonation of the amino group of any tertiary amino compound.		hp.json	a tertiary amine|tertiary amine(1+)|tertiary ammonium ions	http://purl.obolibrary.org/obo/CHEBI_137982		3_STAR
GO:2000270	biolink:BiologicalProcess	negative regulation of fibroblast apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process.		hp.json	negative regulation of fibroblast apoptosis	http://purl.obolibrary.org/obo/GO_2000270		
HP:0001370	biolink:PhenotypicFeature	Rheumatoid arthritis	Inflammatory changes in the synovial membranes and articular structures with widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, as well as atrophy and rarefaction of bony structures.	UMLS:C0003873|SNOMEDCT_US:69896004|MSH:D001172	hp.json	Rheumatoid arthritis|RA	http://purl.obolibrary.org/obo/HP_0001370		
GO:0014010	biolink:BiologicalProcess	Schwann cell proliferation	The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0014010		
HP:0001371	biolink:PhenotypicFeature	Flexion contracture	A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints.	SNOMEDCT_US:203598005|UMLS:C0009918|UMLS:C0009917|SNOMEDCT_US:57048009|MSH:D003286|UMLS:C1850530|SNOMEDCT_US:55033002|UMLS:C0333068|SNOMEDCT_US:7890003|SNOMEDCT_US:88565003|SNOMEDCT_US:385522000	hp.json	Flexion contractures of joints|Flexion contractures|Flexed joint that cannot be straightened	http://purl.obolibrary.org/obo/HP_0001371		
GO:2000271	biolink:BiologicalProcess	positive regulation of fibroblast apoptotic process	Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process.		hp.json	positive regulation of fibroblast apoptosis	http://purl.obolibrary.org/obo/GO_2000271		
HP:0025320	biolink:PhenotypicFeature	Leakage of dye on fundus fluorescein angiography	Leakage of fluorescein dye observed upon retinal fluorescein angiography. Areas of leakage can be appreciated as showing gradual enlargement with blurring of margins.		hp.json	Fluorescein leakage	http://purl.obolibrary.org/obo/HP_0025320		
GO:0016670	biolink:MolecularActivity	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen.	EC:1.8.3.-	hp.json	oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor	http://purl.obolibrary.org/obo/GO_0016670		
HP:0025318	biolink:PhenotypicFeature	Ovarian carcinoma	A malignant neoplasm originating from the surface ovarian epithelium.	NCIT:C4908	hp.json	Ovarian epithelial cancer	http://purl.obolibrary.org/obo/HP_0025318		
HP:0025319	biolink:PhenotypicFeature	Rubeosis iridis	Formation of new blood vessels on the iris. The new vessels do not display the typical radially symmertic growth pattern of normal iris blood vessels, but rather appear disorganized. Rubeosis usually starts from the pupillary border with tiny tufts of dilated capillaries or red spots that can only be appreciated with high magnification.		hp.json		http://purl.obolibrary.org/obo/HP_0025319		
HP:0001349	biolink:PhenotypicFeature	Facial diplegia	Facial diplegia refers to bilateral facial palsy (bilateral facial palsy is much rarer than unilateral facial palsy).	UMLS:C1836003	hp.json	Facial paresis, bilateral|Bilateral facial weakness	http://purl.obolibrary.org/obo/HP_0001349		hposlim_core
GO:2000283	biolink:BiologicalProcess	negative regulation of cellular amino acid biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of cellular amino acid biosynthetic process.		hp.json	negative regulation of cellular amino acid anabolism|negative regulation of amino acid biosynthetic process|negative regulation of cellular amino acid synthesis|negative regulation of cellular amino acid formation|negative regulation of cellular amino acid biosynthesis	http://purl.obolibrary.org/obo/GO_2000283		
HP:0001343	biolink:PhenotypicFeature	Kernicterus	Damage to cerebral nuclei caused in infants by highly increased levels of unconjugated bilirubin. The basal ganglia and brainstem nuclei could be shown to have a yellow staining historically in infants who died of kernicterus, that is, kernicterus is strictly speaking a pathological diagnosis. The presence of kernicterus may be inferred in infants with characteristic acute or chronic bilirubin-induced neurological dysfunction.	SNOMEDCT_US:50143004|SNOMEDCT_US:74925009|MSH:D007647|UMLS:C0022610	hp.json		http://purl.obolibrary.org/obo/HP_0001343		
HP:0025310	biolink:PhenotypicFeature	Oval pupil	An abnormal pupil shape that is elliptical, i.e., egg-like.		hp.json		http://purl.obolibrary.org/obo/HP_0025310		
GO:2000284	biolink:BiologicalProcess	positive regulation of cellular amino acid biosynthetic process	Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process.		hp.json	positive regulation of cellular amino acid biosynthesis|positive regulation of cellular amino acid synthesis|positive regulation of cellular amino acid formation|positive regulation of amino acid biosynthetic process|positive regulation of cellular amino acid anabolism	http://purl.obolibrary.org/obo/GO_2000284		
HP:0001344	biolink:PhenotypicFeature	Absent speech	Complete lack of development of speech and language abilities.	UMLS:C1854882|UMLS:C0746940	hp.json	No speech or language development|No speech development|Lack of language development|Lack of speech|Nonverbal|Absent speech development	http://purl.obolibrary.org/obo/HP_0001344		
HP:0025311	biolink:PhenotypicFeature	Anterior chamber cyst	A closed sac, having a distinct membrane and division compared to the nearby tissue located within the anterior chamber. The sac that may contain air, fluids, or semi-solid material.		hp.json		http://purl.obolibrary.org/obo/HP_0025311		
HP:0025312	biolink:PhenotypicFeature	Esophoria	A form of strabismus with both eyes turned inward to a relatively mild degree, usually defined as less than 10 prism diopters.		hp.json		http://purl.obolibrary.org/obo/HP_0025312		
HP:0001341	biolink:PhenotypicFeature	Olfactory lobe agenesis		UMLS:C1855331	hp.json	Olfactory lobe absence	http://purl.obolibrary.org/obo/HP_0001341		
HP:0001342	biolink:PhenotypicFeature	Cerebral hemorrhage	Hemorrhage into the parenchyma of the brain.	UMLS:C0553692|UMLS:C2937358|MSH:D020300|SNOMEDCT_US:230706003|MSH:D002543|SNOMEDCT_US:274100004	hp.json	Intracerebral hemorrhage|Cerebral haemorrhage|Hemorrhagic stroke|Intracerebral haemorrhage|Bleeding in brain	http://purl.obolibrary.org/obo/HP_0001342		
HP:0025313	biolink:PhenotypicFeature	Exophoria	A form of strabismus with one or both eyes deviated outward to a milder degree than with exotropia.		hp.json		http://purl.obolibrary.org/obo/HP_0025313		
HP:0001347	biolink:PhenotypicFeature	Hyperreflexia	Hyperreflexia is the presence of hyperactive stretch reflexes of the muscles.	SNOMEDCT_US:86854008|UMLS:C0151889|MSH:D012021	hp.json	Increased reflexes|Increased deep tendon reflexes	http://purl.obolibrary.org/obo/HP_0001347		
HP:0025314	biolink:PhenotypicFeature	Choroidal nevus	A benign, flat or slightly elevated melanocytic lesions of the posterior uveawith clearly defined margins. Choroidal nevi tend they remain stable in size, and to display features such as overlying drusen as well as retinal pigment epithelial atrophy, hyperplasia or fibrous metaplasia.		hp.json		http://purl.obolibrary.org/obo/HP_0025314		
GO:2000287	biolink:BiologicalProcess	positive regulation of myotome development	Any process that activates or increases the frequency, rate or extent of myotome development.		hp.json		http://purl.obolibrary.org/obo/GO_2000287		
HP:0001348	biolink:PhenotypicFeature	Brisk reflexes	Tendon reflexes that are noticeably more active than usual (conventionally denoted 3+ on clinical examination). Brisk reflexes may or may not indicate a neurological lesion. They are distinguished from hyperreflexia by the fact that hyerreflexia is characterized by hyperactive repeating (clonic) reflexes, which are considered to be always abnormal.	UMLS:C2673700	hp.json	Brisk deep tendon reflexes	http://purl.obolibrary.org/obo/HP_0001348		
GO:2000288	biolink:BiologicalProcess	positive regulation of myoblast proliferation	Any process that activates or increases the frequency, rate or extent of myoblast proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_2000288		
HP:0025315	biolink:PhenotypicFeature	Exacerbated by head trauma	Applies to a sign or symptom that is worsened, aggravated, or exacerbated by head trauma.		hp.json		http://purl.obolibrary.org/obo/HP_0025315		
HP:0001345	biolink:PhenotypicFeature	Psychotic mentation		UMLS:C4025789	hp.json		http://purl.obolibrary.org/obo/HP_0001345		
HP:0025317	biolink:PhenotypicFeature	Cubitus varus	A deformity of the elbow in which there is a deviation of the forearm toward the midline of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0025317		
GO:0002009	biolink:BiologicalProcess	morphogenesis of an epithelium	The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.		hp.json	epithelium morphogenesis	http://purl.obolibrary.org/obo/GO_0002009		
HP:0001340	biolink:PhenotypicFeature	Enhancement of the C-reflex	Increase in amplitude of a long-loop response upon somatosensory evoked potential testing, representing an electrically evoked myoclonic response.	UMLS:C3552824	hp.json		http://purl.obolibrary.org/obo/HP_0001340		
GO:2000282	biolink:BiologicalProcess	regulation of cellular amino acid biosynthetic process	Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process.		hp.json	regulation of cellular amino acid anabolism|regulation of cellular amino acid biosynthesis|regulation of amino acid biosynthetic process|regulation of cellular amino acid synthesis|regulation of cellular amino acid formation	http://purl.obolibrary.org/obo/GO_2000282		
GO:0002016	biolink:NamedThing	regulation of blood volume by renin-angiotensin			hp.json		http://purl.obolibrary.org/obo/GO_0002016		
GO:0002018	biolink:NamedThing	renin-angiotensin regulation of aldosterone production			hp.json		http://purl.obolibrary.org/obo/GO_0002018		
HP:0025307	biolink:PhenotypicFeature	Acute emergence over hours	Acute appearance of disease manifestations in a period of hours.		hp.json		http://purl.obolibrary.org/obo/HP_0025307		
HP:0025308	biolink:PhenotypicFeature	Acute emergence over days	Acute appearance of disease manifestations in a period of days.		hp.json		http://purl.obolibrary.org/obo/HP_0025308		
HP:0025309	biolink:PhenotypicFeature	Abnormal pupil shape	A deviation from the normal circular shape of the pupil		hp.json	Irregular pupil	http://purl.obolibrary.org/obo/HP_0025309		
GO:0002011	biolink:BiologicalProcess	morphogenesis of an epithelial sheet	The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.		hp.json		http://purl.obolibrary.org/obo/GO_0002011		
GO:2000294	biolink:BiologicalProcess	positive regulation of defecation	Any process that activates or increases the frequency, rate or extent of defecation.		hp.json		http://purl.obolibrary.org/obo/GO_2000294		
HP:0025300	biolink:PhenotypicFeature	Malar rash	An erythematous (red), flat facial rash that affects the skin in the malar area (over the cheekbones) and extends over the bridge of the nose.		hp.json	Cheekbone rash|Butterfly rash	http://purl.obolibrary.org/obo/HP_0025300		
HP:0001355	biolink:PhenotypicFeature	Megalencephaly	Diffuse enlargement of the entire cerebral hemispheres leading to macrocephaly (with or without overlying cortical dysplasia).	MSH:D058627|SNOMEDCT_US:19410003|UMLS:C0221355	hp.json	Macrencephaly|Enlarged brain	http://purl.obolibrary.org/obo/HP_0001355		
HP:0025301	biolink:PhenotypicFeature	Nocturnal	Applies to an abnormality that occurs in or is exacerbated during the night.		hp.json		http://purl.obolibrary.org/obo/HP_0025301		
HP:0025302	biolink:PhenotypicFeature	Diurnal	Applies to a sign, symptom, or other abnormality that occurs in or is exacerbated in the day time.		hp.json		http://purl.obolibrary.org/obo/HP_0025302		
HP:0025303	biolink:PhenotypicFeature	Episodic	Applied to a sign, symptom, or other manifestation that occurs multiple times at usually irregular intervals. The occurences are separated by an interval in which the sign, symptom, or manifestation is not present.		hp.json	Now and then	http://purl.obolibrary.org/obo/HP_0025303		
HP:0025304	biolink:PhenotypicFeature	Periodic	Applies to a sign, symptom, or other manifestation that recurs with a fixed time interval, i.e., the symptom-free periods are always of the same length.		hp.json	Cyclic|Cyclical	http://purl.obolibrary.org/obo/HP_0025304		
HP:0025305	biolink:PhenotypicFeature	Quotidian	Applies to a sign, symptom, or other manifestation that is episodic with a fixed time interval of one day (24 hours).		hp.json		http://purl.obolibrary.org/obo/HP_0025305		
HP:0001357	biolink:PhenotypicFeature	Plagiocephaly	Asymmetric head shape, which is usually a combination of unilateral occipital flattening with ipsilateral frontal prominence, leading to rhomboid cranial shape.	UMLS:C4072830|UMLS:C4280598|MSH:D059041|UMLS:C4280597|UMLS:C0265529|UMLS:C4280807|SNOMEDCT_US:254024005|SNOMEDCT_US:21850008|MSH:D049068|UMLS:C1450010	hp.json	Flattening of cranium|Rhomboid shaped head|Deformational plagiocephaly|Rhomboid shaped cranium|Asymmetry of the posterior skull|Flattening of head|Asymmetry of the posterior head|Flat head syndrome|Positional plagiocephaly|Flattening of skull|Asymmetry of the posterior cranium|Flattening of cranial vault|Rhomboid shaped skull|Flat head	http://purl.obolibrary.org/obo/HP_0001357		hposlim_core
HP:0025306	biolink:PhenotypicFeature	Acute emergence over minutes	Acute appearance of disease manifestations in a period of minutes.		hp.json		http://purl.obolibrary.org/obo/HP_0025306		
GO:2000290	biolink:BiologicalProcess	regulation of myotome development	Any process that modulates the frequency, rate or extent of myotome development.		hp.json		http://purl.obolibrary.org/obo/GO_2000290		
HP:0001350	biolink:PhenotypicFeature	Slurred speech	Abnormal coordination of muscles involved in speech.	UMLS:C0234518|SNOMEDCT_US:289195008	hp.json	Slurred speech	http://purl.obolibrary.org/obo/HP_0001350		
GO:2000291	biolink:BiologicalProcess	regulation of myoblast proliferation	Any process that modulates the frequency, rate or extent of myoblast proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_2000291		
HP:0001351	biolink:PhenotypicFeature	Jerk-locked premyoclonus spikes	Jerk-locked averaging (JLA) is used to record the timing and distribution of brain activity preceding brisk involuntary movements such as those observed in patients with myoclonus. JLA is capable of revealing a premyoclonus spike in the absence of paroxysmal activity in the routine EEG.	UMLS:C3552825	hp.json		http://purl.obolibrary.org/obo/HP_0001351		
GO:2000292	biolink:BiologicalProcess	regulation of defecation	Any process that modulates the frequency, rate or extent of defecation.		hp.json		http://purl.obolibrary.org/obo/GO_2000292		
GO:2000293	biolink:BiologicalProcess	negative regulation of defecation	Any process that stops, prevents or reduces the frequency, rate or extent of defecation.		hp.json		http://purl.obolibrary.org/obo/GO_2000293		
GO:0110011	biolink:BiologicalProcess	regulation of basement membrane organization	Any process that modulates the frequency, rate or extent of the assembly, disassembly or arrangement of constituent parts of the basement membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0110011		
HP:0001967	biolink:PhenotypicFeature	Diffuse mesangial sclerosis	Diffuse sclerosis of the mesangium, as manifestated by diffuse mesangial matrix expansion.	SNOMEDCT_US:111406002|UMLS:C0268747|MSH:C537346	hp.json	Diffuse mesangial sclerosis glomerulopathy|Mesangial sclerosis	http://purl.obolibrary.org/obo/HP_0001967		
HP:0001965	biolink:PhenotypicFeature	Abnormal scalp morphology	Any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows.	UMLS:C4025734	hp.json	Anomaly of scalp|Abnormality of the scalp	http://purl.obolibrary.org/obo/HP_0001965		
HP:0001966	biolink:PhenotypicFeature	Abnormal glomerular mesangium morphology	An abnormality of the mesangium, i.e., of the central part of the renal glomerulus between capillaries.	UMLS:C4025733	hp.json	Mesangial abnormality|Abnormality glomerular mesangium morphology|Abnormality of the glomerular mesangium	http://purl.obolibrary.org/obo/HP_0001966		
HP:0001969	biolink:PhenotypicFeature	Abnormal tubulointerstitial morphology	An abnormality that involves the tubules and interstitial tissue of the kidney.	UMLS:C0041349|MSH:D009395|UMLS:C4025732|SNOMEDCT_US:28689008|SNOMEDCT_US:428255004	hp.json	Tubulointerstitial abnormality|Tubulointerstitial nephropathy	http://purl.obolibrary.org/obo/HP_0001969		
CHEBI:16737	biolink:ChemicalSubstance	creatinine	A lactam obtained by formal cyclocondensation of creatine. It is a metabolite of creatine.	PMID:22498455|PMID:22432114|KEGG:C00791|CAS:60-27-5|PMID:21775764|PMID:22390548|CAS:60-27-5|PMID:22223530|PMID:11256540|PMID:22166252|PMID:22207347|HMDB:HMDB0000562|PMID:22441184|PMID:22121923|PMID:18182718|PMID:22349552|Wikipedia:Creatinine|PMID:11981083|MetaCyc:CREATININE|PMID:17422601|PMID:19236048|PMID:22459582|PMID:19968328|PMID:22331238|PMID:19715855|PMID:22212624|PMID:22047975|Reaxys:112064|KEGG:D03600|CAS:60-27-5|PMID:22338083|PMID:17190852	hp.json	1-Methylhydantoin-2-imide|creatinine|creatinine|1-Methylglycocyamidine|2-Amino-1-methylimidazolin-4-one|2-imino-1-methylimidazolidin-4-one|2-amino-1,5-dihydro-1-methyl-4H-Imidazol-4-one|creatinina|Creatinine|1-methylglycocyamidine|Kreatinin|Creatine anhydride	http://purl.obolibrary.org/obo/CHEBI_16737		3_STAR
HP:0001960	biolink:PhenotypicFeature	Hypokalemic metabolic alkalosis		UMLS:C0740898	hp.json		http://purl.obolibrary.org/obo/HP_0001960		
CHEBI:16733	biolink:ChemicalSubstance	D-alpha-amino acid		KEGG:C00405	hp.json	D-Amino acid|D-alpha-amino acids|D-alpha-amino acids|D-alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_16733		3_STAR
HP:0001963	biolink:PhenotypicFeature	Abnormal speech discrimination	A type of hearing impairment prominently characterized by a difficulty in understanding speech, rather than an inability to hear speech. Poor speech discrimination is a very common symptom of high frequency hearing loss.	UMLS:C1836752	hp.json	Abnormal speech discrimination|Poor speech discrimination	http://purl.obolibrary.org/obo/HP_0001963		
HP:0001964	biolink:PhenotypicFeature	Aplasia/Hypoplasia of metatarsal bones	Absence or underdevelopment of the metatarsal bones.	UMLS:C1860182	hp.json	Absent/underdeveloped long bone of foot|Absent/hypoplastic metacarpals|Absent/hypoplastic metatarsals|Absent/small long bone of foot|Aplastic/hypoplastic metatarsals|Absent or hypoplastic metatarsal	http://purl.obolibrary.org/obo/HP_0001964		
HP:0001961	biolink:PhenotypicFeature	Hypoplastic heart		UMLS:C3151525	hp.json	Small heart|Underdeveloped heart	http://purl.obolibrary.org/obo/HP_0001961		
HP:0001962	biolink:PhenotypicFeature	Palpitations	A sensation that the heart is pounding or racing, which is a non-specific sign but may be a manifestation of arrhythmia.	SNOMEDCT_US:80313002|UMLS:C0030252	hp.json	Missed heart beat|Heart palpitations|Skipped heart beat|Palpitations	http://purl.obolibrary.org/obo/HP_0001962		
GO:0110023	biolink:BiologicalProcess	negative regulation of cardiac muscle myoblast proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle myoblast proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0110023		
GO:0110024	biolink:BiologicalProcess	positive regulation of cardiac muscle myoblast proliferation	Any process that activates or increases the frequency, rate or extent of cardiac muscle myoblast proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0110024		
GO:0110021	biolink:BiologicalProcess	cardiac muscle myoblast proliferation	The multiplication or reproduction of cardiac muscle myoblasts, resulting in the expansion of a cardiac muscle myoblast cell population.  A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.		hp.json		http://purl.obolibrary.org/obo/GO_0110021		
GO:0099143	biolink:CellularComponent	presynaptic actin cytoskeleton	The actin cytoskeleton that is part of a presynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0099143		goslim_synapse
GO:0110022	biolink:BiologicalProcess	regulation of cardiac muscle myoblast proliferation	Any process that modulates the frequency, rate or extent of cardiac muscle myoblast proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0110022		
HP:0001978	biolink:PhenotypicFeature	Extramedullary hematopoiesis	The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms.	UMLS:C1292120|UMLS:C2613439|SNOMEDCT_US:42952007|SNOMEDCT_US:124958002	hp.json	Extramedullary erythropoiesis	http://purl.obolibrary.org/obo/HP_0001978		
GO:0099140	biolink:BiologicalProcess	presynaptic actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton.		hp.json		http://purl.obolibrary.org/obo/GO_0099140		goslim_synapse
GO:0110020	biolink:BiologicalProcess	regulation of actomyosin structure organization	Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin.		hp.json		http://purl.obolibrary.org/obo/GO_0110020		
HP:0001976	biolink:PhenotypicFeature	Reduced antithrombin III activity	An abnormality of coagulation related to a decreased concentration of antithrombin-III.	SNOMEDCT_US:36351005|MSH:D020152|UMLS:C0272375	hp.json	Decreased antithrombin III|Anti-thrombin III deficiency|Antithrombin III deficiency	http://purl.obolibrary.org/obo/HP_0001976		
HP:0001977	biolink:PhenotypicFeature	Abnormal thrombosis	Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis).	UMLS:C4025731	hp.json	Abnormal blood clotting|Abnormal blood clot	http://purl.obolibrary.org/obo/HP_0001977		
HP:0001970	biolink:PhenotypicFeature	Tubulointerstitial nephritis	A form of inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.	SNOMEDCT_US:28689008|SNOMEDCT_US:428255004|UMLS:C0041349|MSH:D009395	hp.json	Nephritis, Tubulointerstitial|Interstitial nephritis	http://purl.obolibrary.org/obo/HP_0001970		
HP:0001971	biolink:PhenotypicFeature	Hypersplenism	A malfunctioning of the spleen in which it prematurely destroys red blood cells.	UMLS:C0020532|SNOMEDCT_US:58381000|MSH:D006971	hp.json		http://purl.obolibrary.org/obo/HP_0001971		
HP:0001974	biolink:PhenotypicFeature	Leukocytosis	An abnormal increase in the number of leukocytes in the blood.	MSH:D007964|UMLS:C0023518|SNOMEDCT_US:111583006	hp.json	Increased blood leukocyte number|High white blood count|Elevated white blood count	http://purl.obolibrary.org/obo/HP_0001974		
HP:0001975	biolink:PhenotypicFeature	Decreased platelet glycoprotein IIb-IIIa	Decreased cell membrane concentration of glycoprotein IIb-IIIa.	UMLS:C0040015|MSH:D013915|UMLS:C4021767|SNOMEDCT_US:32942005	hp.json	Glanzmann thrombasthenia|Reduced level of platelet glycoprotein IIb/IIIa complex	http://purl.obolibrary.org/obo/HP_0001975		
HP:0001972	biolink:PhenotypicFeature	Macrocytic anemia	A type of anemia characterized by increased size of erythrocytes with increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).	UMLS:C0002886|MSH:D000748|SNOMEDCT_US:83414005	hp.json	Macrocytic anaemia	http://purl.obolibrary.org/obo/HP_0001972		
HP:0001973	biolink:PhenotypicFeature	Autoimmune thrombocytopenia	The presence of thrombocytopenia in combination with detection of antiplatelet antibodies.	UMLS:C0920163|SNOMEDCT_US:13172003|SNOMEDCT_US:128091003|SNOMEDCT_US:234490009|MSH:D016553|UMLS:C0242584|SNOMEDCT_US:32273002|UMLS:C0398650	hp.json	Idiopathic thrombocytopenia|Idiopathic thrombocytopenic purpura|Immune thrombocytopenia	http://purl.obolibrary.org/obo/HP_0001973		
GO:0099111	biolink:BiologicalProcess	microtubule-based transport	A microtubule-based process that results in the transport of organelles, other microtubules, or other cellular components.  Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.		hp.json		http://purl.obolibrary.org/obo/GO_0099111		
GO:0099112	biolink:BiologicalProcess	microtubule polymerization based protein transport	The transport of a protein driven by polymerization of a microtubule to which it is attached.		hp.json		http://purl.obolibrary.org/obo/GO_0099112		
HP:0001945	biolink:PhenotypicFeature	Fever	Body temperature elevated above the normal range.	SNOMEDCT_US:386661006|UMLS:C0015967|MSH:D005334|SNOMEDCT_US:50177009	hp.json	Pyrexia|Fever|Hyperthermia	http://purl.obolibrary.org/obo/HP_0001945		
HP:0001946	biolink:PhenotypicFeature	Ketosis	Presence of elevated levels of ketone bodies in the body.	UMLS:C0235430|UMLS:C0022638|SNOMEDCT_US:2538008|SNOMEDCT_US:213281004|MSH:D007662	hp.json	High levels of ketone bodies|Hyperketosis	http://purl.obolibrary.org/obo/HP_0001946		
HP:0001943	biolink:PhenotypicFeature	Hypoglycemia	A decreased concentration of glucose in the blood.	UMLS:C0020615|SNOMEDCT_US:237630007|SNOMEDCT_US:302866003|MSH:D007003|SNOMEDCT_US:271327008	hp.json	Hypoglycaemia|Low blood sugar	http://purl.obolibrary.org/obo/HP_0001943		
HP:0001944	biolink:PhenotypicFeature	Dehydration		SNOMEDCT_US:34095006|MSH:D003681|UMLS:C0011175	hp.json	Dehydration|Exsiccosis	http://purl.obolibrary.org/obo/HP_0001944		
HP:0001949	biolink:PhenotypicFeature	Hypokalemic alkalosis		SNOMEDCT_US:22774003|UMLS:C0085570	hp.json		http://purl.obolibrary.org/obo/HP_0001949		
HP:0001947	biolink:PhenotypicFeature	Renal tubular acidosis	Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia, potentially leading to complications including hypokalemia, hypercalcinuria, nephrolithiasis and nephrocalcinosis.	UMLS:C0001126|MSH:D000141|SNOMEDCT_US:1776003	hp.json	Accumulation of acid in body due to kidney problem	http://purl.obolibrary.org/obo/HP_0001947		
HP:0001948	biolink:PhenotypicFeature	Alkalosis	Depletion of acid or accumulation base in the body fluids.	UMLS:C0002063|MSH:D000471|SNOMEDCT_US:21420006	hp.json		http://purl.obolibrary.org/obo/HP_0001948		
HP:0001941	biolink:PhenotypicFeature	Acidosis	Abnormal acid accumulation or depletion of base.	MSH:D000138|SNOMEDCT_US:51387008|UMLS:C0001122	hp.json		http://purl.obolibrary.org/obo/HP_0001941		
HP:0001942	biolink:PhenotypicFeature	Metabolic acidosis	Metabolic acidosis (MA) is characterized by a fall in blood pH due to a reduction of serum bicarbonate concentration. This can occur as a result of either the accumulation of acids (high anion gap MA) or the loss of bicarbonate from the gastrointestinal tract or the kidney (hyperchloremic MA). By definition, MA is not due to a respirary cause.	MSH:D000138|SNOMEDCT_US:59455009|UMLS:C0220981	hp.json		http://purl.obolibrary.org/obo/HP_0001942		
GO:0099118	biolink:BiologicalProcess	microtubule-based protein transport	A microtubule-based process that results in the transport of proteins.		hp.json		http://purl.obolibrary.org/obo/GO_0099118		
GO:0099124	biolink:BiologicalProcess	axonal dopamine secretion	The regulated release of dopamine from an axon.		hp.json	axonal dopamine release|axonal DA release	http://purl.obolibrary.org/obo/GO_0099124		
GO:0099123	biolink:BiologicalProcess	somato-dendritic dopamine secretion	The regulated release of dopamine from the somatodendritic compartment (cell body or dendrites) of a neuron.		hp.json	STD dopamine release|somatodendritic dopamine release|STD DA release	http://purl.obolibrary.org/obo/GO_0099123		
GO:0110043	biolink:BiologicalProcess	positive regulation of pharynx morphogenesis	Any process that activates or increases the frequency, rate or extent of pharynx morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_0110043		
HP:0001956	biolink:PhenotypicFeature	Truncal obesity	Obesity located preferentially in the trunk of the body as opposed to the extremities.	MSH:D056128|SNOMEDCT_US:248311001|UMLS:C0311277	hp.json	Truncal obesity|Centripetal obesity	http://purl.obolibrary.org/obo/HP_0001956		
GO:0110041	biolink:BiologicalProcess	regulation of pharynx morphogenesis	Any process that modulates the frequency, rate or extent of pharynx morphogenesis, the process in which the anatomical structure of the pharynx is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0110041		
GO:0110042	biolink:BiologicalProcess	negative regulation of pharynx morphogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of pharynx morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_0110042		
HP:0001954	biolink:PhenotypicFeature	Recurrent fever	Periodic (episodic or recurrent) bouts of fever.	UMLS:C0277799|SNOMEDCT_US:77957000	hp.json	Increased body temperature, episodic|Hyperthermia, episodic|Episodic fever|Intermittent fever	http://purl.obolibrary.org/obo/HP_0001954		
HP:0001955	biolink:PhenotypicFeature	Unexplained fevers	Episodes of fever for which no infectious cause can be identified.	UMLS:C1844662	hp.json	Unexplained fevers	http://purl.obolibrary.org/obo/HP_0001955		
GO:0110040	biolink:BiologicalProcess	pharynx morphogenesis	The process in which the anatomical structures of the pharynx are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0110040		
HP:0001958	biolink:PhenotypicFeature	Nonketotic hypoglycemia		UMLS:C1865292	hp.json		http://purl.obolibrary.org/obo/HP_0001958		
HP:0001959	biolink:PhenotypicFeature	Polydipsia	Excessive thirst manifested by excessive fluid intake.	MSH:D059606|UMLS:C0085602|SNOMEDCT_US:267026004|SNOMEDCT_US:17173007	hp.json	Extreme thirst	http://purl.obolibrary.org/obo/HP_0001959		
HP:0001952	biolink:PhenotypicFeature	Glucose intolerance	Glucose intolerance (GI) can be defined as dysglycemia that comprises both prediabetes and diabetes. It includes the conditions of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and diabetes mellitus (DM).	UMLS:C0235401	hp.json	Glucose intolerance|Abnormal glucose tolerance	http://purl.obolibrary.org/obo/HP_0001952		
HP:0001953	biolink:PhenotypicFeature	Diabetic ketoacidosis	A type of diabetic metabolic abnormality with an accumulation of ketone bodies.	SNOMEDCT_US:420422005|MSH:D016883|UMLS:C0011880	hp.json	Diabetic ketosis	http://purl.obolibrary.org/obo/HP_0001953		
CHEBI:16742	biolink:ChemicalSubstance	orotic acid	A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.	PMID:22371390|MetaCyc:OROTATE|PMID:22863860|Wikipedia:Orotic_acid|PDBeChem:ORO|Gmelin:101990|Drug_Central:3402|Beilstein:383901|PMID:22019295|PMID:11059538|PMID:22770225|DrugBank:DB02262|KNApSAcK:C00019689|PMID:7264771|CAS:65-86-1|Reaxys:383901|PMID:22307261|PMID:22634191|HMDB:HMDB0000226|PMID:22707164|KEGG:D00055|KEGG:C00295|CAS:65-86-1|PMID:22285839|CAS:65-86-1	hp.json	OROTIC ACID|Uracil-6-carboxylic acid|2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid|Orotsaeure|Orotic acid	http://purl.obolibrary.org/obo/CHEBI_16742		3_STAR
HP:0001950	biolink:PhenotypicFeature	Respiratory alkalosis	Alkalosis due to excess loss of carbon dioxide from the body.	SNOMEDCT_US:111378004|MSH:D000472|UMLS:C0002064	hp.json		http://purl.obolibrary.org/obo/HP_0001950		
HP:0001951	biolink:PhenotypicFeature	Episodic ammonia intoxication		UMLS:C1839541	hp.json		http://purl.obolibrary.org/obo/HP_0001951		
UBERON:0008397	biolink:AnatomicalEntity	tracheobronchial epithelium	Epithelium pertaining to the trachea and bronchi.	BTO:0002925|CALOHA:TS-1063	hp.json	bronchotracheal epithelium	http://purl.obolibrary.org/obo/UBERON_0008397		
GO:0038187	biolink:MolecularActivity	pattern recognition receptor activity	Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.	Wikipedia:Pattern_recognition_receptor	hp.json	MAMP receptor activity|PRR|signaling pattern recognition receptor activity|PAMP receptor activity|PRR activity|pathogen associated molecular pattern receptor activity|macrophage receptor activity|microbe-associated molecular pattern receptor activity	http://purl.obolibrary.org/obo/GO_0038187		
HP:0011330	biolink:PhenotypicFeature	Metopic synostosis	Premature fusion of the metopic suture.	UMLS:C1860819|UMLS:C0432122|MSH:C562951|MSH:D003398|SNOMEDCT_US:109409003	hp.json	Metopic craniosynostosis|Metopic suture craniosynostosis	http://purl.obolibrary.org/obo/HP_0011330		hposlim_core
HP:0011331	biolink:PhenotypicFeature	Hemifacial atrophy	Unilateral atrophy of facial tissues, including muscles, bones and skin.	SNOMEDCT_US:95834000|SNOMEDCT_US:718224004|MSH:D005150|UMLS:C0015458	hp.json	Atrophy of half of face|Atrophy of one side of the face|Facial hemiatrophy	http://purl.obolibrary.org/obo/HP_0011331		hposlim_core
HP:0011332	biolink:PhenotypicFeature	Hemifacial hypoplasia	Unilateral underdevelopment of the facial tissues, including muscles and bones.	UMLS:C3495417|MSH:D006053|UMLS:C4023411|SNOMEDCT_US:254025006	hp.json	Decrease in size of half of face|Hemifacial microsomia|Shrinking of half of face|Decrease in size of one side of the face|Shrinking of one side of the face|Decreased size of half of the face|Decreased size of one side of the face	http://purl.obolibrary.org/obo/HP_0011332		
HP:0011333	biolink:PhenotypicFeature	Asymmetric crying face	Asymmetry observed in the face of a neonate or infant whose face appears symmetric at rest and asymmetric during crying as the mouth is pulled downward on one side while not moving on the other side.	UMLS:C4280327|UMLS:C0431406|SNOMEDCT_US:51409009|MSH:C535349	hp.json	Partial unilateral facial paresis|Hypoplasia of depressor angula oris muscle|Asymmetric crying face	http://purl.obolibrary.org/obo/HP_0011333		
GO:0099177	biolink:BiologicalProcess	regulation of trans-synaptic signaling	Any process that modulates the frequency, rate or extent of trans-synaptic signaling.		hp.json		http://purl.obolibrary.org/obo/GO_0099177		
HP:0011334	biolink:PhenotypicFeature	Facial shape deformation		UMLS:C4021159	hp.json	Facial shape compression|Facial shape deformation|Distortion of facial shape	http://purl.obolibrary.org/obo/HP_0011334		
HP:0011335	biolink:PhenotypicFeature	Frontal hirsutism	Excessive amount of hair growth on forehead.	UMLS:C1839830	hp.json	Hairy forehead|Hirsute forehead	http://purl.obolibrary.org/obo/HP_0011335		
GO:0099175	biolink:BiologicalProcess	regulation of postsynapse organization	Any process that modulates the physical form of a postsynapse.		hp.json	regulation of postsynapse organisation|regulation of postsynapse structure|regulation of postsynapse organization and biogenesis	http://purl.obolibrary.org/obo/GO_0099175		goslim_synapse
HP:0011336	biolink:PhenotypicFeature	Bitemporal forceps marks	Bilateral temporal scarlike defects, which are said to resemble forceps marks.	UMLS:C4023409|UMLS:C4020754	hp.json	Congenital, bilateral, scarlike facial lesions|Congenital ectodermal dysplasia of the face|Bitemporal aplasia cutis congenita|Temporal skin defect|Focal facial dermal dysplasia	http://purl.obolibrary.org/obo/HP_0011336		
GO:0099173	biolink:BiologicalProcess	postsynapse organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.		hp.json	postsynapse organisation|postsynapse organization and biogenesis|postsynapse morphogenesis|postsynapse development	http://purl.obolibrary.org/obo/GO_0099173		goslim_synapse
GO:0099174	biolink:BiologicalProcess	regulation of presynapse organization	Any process that modulates the physical form of a presynapse.		hp.json	regulation of presynapse organisation|regulation of presynapse structure|regulation of presynapse organization and biogenesis	http://purl.obolibrary.org/obo/GO_0099174		goslim_synapse
GO:0099171	biolink:BiologicalProcess	presynaptic modulation of chemical synaptic transmission	Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.		hp.json		http://purl.obolibrary.org/obo/GO_0099171		goslim_synapse
GO:0099172	biolink:BiologicalProcess	presynapse organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse.		hp.json	presynapse development|presynapse organisation|presynapse organization and biogenesis|presynapse morphogenesis	http://purl.obolibrary.org/obo/GO_0099172		goslim_synapse
GO:0099170	biolink:BiologicalProcess	postsynaptic modulation of chemical synaptic transmission	Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission.		hp.json		http://purl.obolibrary.org/obo/GO_0099170		goslim_synapse
HP:0410148	biolink:PhenotypicFeature	Idiopathic anaphylaxis	A rare form of anaphylaxis for which triggers cannot be identified despite a detailed history and careful diagnostic assessment.		hp.json		http://purl.obolibrary.org/obo/HP_0410148		
HP:0410147	biolink:PhenotypicFeature	Eosinophilic infiltration in the stomach mucosa	Infiltration of eosinophils in the stomach mucosa, that is diagnosed by an upper endoscopy and microscopy that shows more than 20 eosinophils per high-power field in association with peripheral eosinophilia and the absence of secondary cause of eosinophilia.		hp.json	Eosinophilic gastritis	http://purl.obolibrary.org/obo/HP_0410147		
HP:0410146	biolink:PhenotypicFeature	Increased biotinidase level	An increase in biotinidase level, an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation.		hp.json		http://purl.obolibrary.org/obo/HP_0410146		
HP:0410145	biolink:PhenotypicFeature	Decreased biotinidase level	A decrease in the biotinidase level, an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation.		hp.json		http://purl.obolibrary.org/obo/HP_0410145		
HP:0410149	biolink:PhenotypicFeature	Drug-induced anaphylaxis	A form of anaphylaxis that is triggered by intake of drugs or medications.		hp.json	Drug induced anaphylaxis	http://purl.obolibrary.org/obo/HP_0410149		
HP:0011337	biolink:PhenotypicFeature	Abnormality of mouth size		UMLS:C4023408	hp.json	Anomaly of mouth size|Abnormality of mouth size	http://purl.obolibrary.org/obo/HP_0011337		
HP:0011338	biolink:PhenotypicFeature	Abnormality of mouth shape	An abnormality of the outline, configuration, or contour of the mouth.	UMLS:C4023407|Fyler:4874	hp.json	Unusual mouth shape|Anomaly of mouth shape|Abnormality of mouth shape	http://purl.obolibrary.org/obo/HP_0011338		
HP:0011339	biolink:PhenotypicFeature	Abnormality of upper lip vermillion	An abnormality of the vermilion border, the sharp demarcation between the lip (red colored) and the adjacent normal skin.	UMLS:C4023406	hp.json	Anomaly of the upper lip vermillion|Abnormality of the red part of the upper lip|Deformity of the upper lip vermillion|Malformation of the upper lip vermillion	http://purl.obolibrary.org/obo/HP_0011339		
HP:0410144	biolink:PhenotypicFeature	Abnormal biotinidase level	An abnormality in the biotinidase level, an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation.		hp.json		http://purl.obolibrary.org/obo/HP_0410144		
HP:0011320	biolink:PhenotypicFeature	Unilambdoid synostosis	Premature synostosis of only one lambdoid suture.	UMLS:C4021162	hp.json	Unilateral lambdoid suture synostosis|Unilateral lambdoid craniosynostosis	http://purl.obolibrary.org/obo/HP_0011320		hposlim_core
HP:0011321	biolink:PhenotypicFeature	Left unilambdoid synostosis	Premature synostosis of only the left lambdoid suture.	UMLS:C4023415	hp.json		http://purl.obolibrary.org/obo/HP_0011321		
HP:0011322	biolink:PhenotypicFeature	Right unilambdoid synostosis	Premature synostosis of only the right lambdoid suture.	UMLS:C4023414	hp.json		http://purl.obolibrary.org/obo/HP_0011322		
GO:0099188	biolink:BiologicalProcess	postsynaptic cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton.		hp.json		http://purl.obolibrary.org/obo/GO_0099188		goslim_synapse
HP:0011323	biolink:PhenotypicFeature	Cleft of chin	Incomplete fusion of the chin, resulting from a developmental defect and manifesting as a midline cleft or fissure of the chin.	UMLS:C1849227	hp.json	Cleft of chin|Midline defect of chin	http://purl.obolibrary.org/obo/HP_0011323		
HP:0011324	biolink:PhenotypicFeature	Multiple suture craniosynostosis	Craniosynostosis involving at least 2 cranial sutures, where the exact pattern of sutures fused has not been precisely specified.	UMLS:C4021161	hp.json	Multisutural craniosynostosis	http://purl.obolibrary.org/obo/HP_0011324		
GO:0038170	biolink:BiologicalProcess	somatostatin signaling pathway	A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription.		hp.json	SST signaling pathway|somatostatin-activated somatostatin receptor signaling pathway|somatostatin signalling pathway|somatotrophin release inhibiting factor signaling pathway|SRIF signaling pathway|somatostatin-mediated signaling pathway	http://purl.obolibrary.org/obo/GO_0038170		
GO:0099187	biolink:BiologicalProcess	presynaptic cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures and their associated proteins in the presynaptic cytoskeleton.		hp.json		http://purl.obolibrary.org/obo/GO_0099187		
HP:0011325	biolink:PhenotypicFeature	Pansynostosis	Craniosynostosis of all calvarial sutures.	UMLS:C4021827	hp.json	Sysnostosis of all cranial sutures	http://purl.obolibrary.org/obo/HP_0011325		
HP:0410137	biolink:PhenotypicFeature	Solar urticaria	Urticaria in response to exposure to ultraviolet-A (UVA), ultraviolet-B (UVB), visible and rarely infrared light.		hp.json		http://purl.obolibrary.org/obo/HP_0410137		
GO:0038169	biolink:BiologicalProcess	somatostatin receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process.		hp.json	SSTR signaling pathway|SST receptor signaling pathway	http://purl.obolibrary.org/obo/GO_0038169		
HP:0410136	biolink:PhenotypicFeature	Aquagenic urticaria	A form of physical urticaria, in which contact with water, regardless of its temperature and source, evokes pruritic follicular wheals on the skin.		hp.json		http://purl.obolibrary.org/obo/HP_0410136		
HP:0410135	biolink:PhenotypicFeature	Cold urticaria	Urticaria may be caused by cold temperatures.		hp.json		http://purl.obolibrary.org/obo/HP_0410135		
HP:0410134	biolink:PhenotypicFeature	Physical urticaria	Urticaria caused by physical agents, such as heat, cold, light, friction.		hp.json		http://purl.obolibrary.org/obo/HP_0410134		
HP:0410139	biolink:PhenotypicFeature	Exercise induced anaphylaxis	Anaphylaxis after physical activity.		hp.json		http://purl.obolibrary.org/obo/HP_0410139		
HP:0410138	biolink:PhenotypicFeature	Vibratory urticaria	Urticaria in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum.		hp.json		http://purl.obolibrary.org/obo/HP_0410138		
HP:0011326	biolink:PhenotypicFeature	Anterior plagiocephaly	Asymmetry of the anterior part of the skull.	SNOMEDCT_US:254020001|UMLS:C4280329|UMLS:C4280328|UMLS:C0432124|UMLS:C4280330|UMLS:C4023413	hp.json	Positional anterior plagiocephaly|Unicoronal craniosynostosis|Coronal synostosis|Deformational frontal plagiocephaly|Frontal plagiocephaly|Anterior flat head syndrome|Deformational anterior plagiocephaly|Positional frontal plagiocephaly	http://purl.obolibrary.org/obo/HP_0011326		
HP:0011327	biolink:PhenotypicFeature	Posterior plagiocephaly	Asymmetry of the posterior part of the skull.	UMLS:C4021160	hp.json	Occipital plagiocephaly|Deformational posterior plagiocephaly	http://purl.obolibrary.org/obo/HP_0011327		
HP:0011328	biolink:PhenotypicFeature	Abnormality of fontanelles	An abnormality of the fontanelle.	UMLS:C4020755	hp.json	Anomaly of the fontanelles	http://purl.obolibrary.org/obo/HP_0011328		hposlim_core
HP:0011329	biolink:PhenotypicFeature	Abnormality of cranial sutures	Any anomaly of a cranial suture, that is one of the six membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant.	UMLS:C4023412	hp.json	Abnormality of the bregma sutures|Abnormality of cranial sutures|Abnormality of the skull suture|Abnormality of the cranial sutures|Abnormality of the calvarium sutures	http://purl.obolibrary.org/obo/HP_0011329		
HP:0410133	biolink:PhenotypicFeature	Chronic idiopathic urticaria	Urticaria characterized by spontaneously recurring hives for 6 weeks or longer.		hp.json	Chronic spontaneous urticaria|CSU|CIU	http://purl.obolibrary.org/obo/HP_0410133		
HP:0410132	biolink:PhenotypicFeature	Increased level of L-pyroglutamic acid in urine	An increase in the level of L-pyroglutamic acid in the urine.		hp.json	Increased level of 5-oxo-L-proline in urine|Elevated urine 5-oxoproline	http://purl.obolibrary.org/obo/HP_0410132		
GO:0099157	biolink:BiologicalProcess	trans-synaptic signalling via exosome	Transynaptic signaling in which the ligand is carried across the synapse by an exosome.		hp.json	exosome mediated transynaptic signalling	http://purl.obolibrary.org/obo/GO_0099157		goslim_synapse
HP:0011310	biolink:PhenotypicFeature	Bridged palmar crease	A crease that connects the proximal and distal transverse palmar creases.	UMLS:C4021166	hp.json	Transitional palmar crease|Bridged palm line	http://purl.obolibrary.org/obo/HP_0011310		
HP:0011311	biolink:PhenotypicFeature	Sydney crease	Extension of the proximal transverse crease (five finger crease) to the ulnar edge of the palm.	UMLS:C4023420	hp.json		http://purl.obolibrary.org/obo/HP_0011311		
GO:0099156	biolink:BiologicalProcess	cell-cell signaling via exosome	Cell-cell signaling in which the ligand is carried between cells by an exosome.		hp.json	exosome mediated	http://purl.obolibrary.org/obo/GO_0099156		
HP:0011312	biolink:PhenotypicFeature	Fused nails	A nail plate that has a longitudinal separation with partially separated nails, each with a separate lateral radius of curvature.	UMLS:C4023419	hp.json	Fused nails	http://purl.obolibrary.org/obo/HP_0011312		
HP:0011313	biolink:PhenotypicFeature	Narrow nail	Decreased width of nail.	UMLS:C4021829	hp.json	Narrow nail	http://purl.obolibrary.org/obo/HP_0011313		
HP:0011314	biolink:PhenotypicFeature	Abnormal long bone morphology	An abnormality of size or shape of the long bones.	UMLS:C4021165	hp.json	Abnormal shape of long bone|Abnormality of the tubular bones|Abnormality of long bone morphology	http://purl.obolibrary.org/obo/HP_0011314		
HP:0001989	biolink:PhenotypicFeature	Fetal akinesia sequence	Decreased fetal activity associated with multiple joint contractures, facial anomalies and pulmonary hypoplasia. Ultrasound examination may reveal polyhydramnios, ankylosis, scalp edema, and decreased chest movements (reflecting pulmonary hypoplasia).	SNOMEDCT_US:401138005|MSH:C536647|UMLS:C1276035|UMLS:C3151520	hp.json	Fetal akinesia|Foetal akinesia sequence|Foetal akinesia|Early severe foetal akinesia sequence|Early severe fetal akinesia sequence	http://purl.obolibrary.org/obo/HP_0001989		hposlim_core
HP:0001987	biolink:PhenotypicFeature	Hyperammonemia	An increased concentration of ammonia in the blood.	MSH:D022124|SNOMEDCT_US:9360008|UMLS:C0220994	hp.json	High blood ammonia levels	http://purl.obolibrary.org/obo/HP_0001987		
HP:0001988	biolink:PhenotypicFeature	Recurrent hypoglycemia	Recurrent episodes of decreased concentration of glucose in the blood.	UMLS:C1846288	hp.json	hypoglycaemia, recurrent|Recurrent low blood sugar levels|Recurrent hypoglycemic episodes|Recurrent hypoglycaemia|Hypoglycemic episodes|hypoglycemia, recurrent	http://purl.obolibrary.org/obo/HP_0001988		
HP:0001981	biolink:PhenotypicFeature	Schistocytosis	The presence of an abnormal number of fragmented red blood cells (schistocytes) in the blood.	SNOMEDCT_US:385472000|UMLS:C0344386	hp.json	Schistocytes	http://purl.obolibrary.org/obo/HP_0001981		
CHEBI:16716	biolink:ChemicalSubstance	benzene	A six-carbon aromatic annulene in which each carbon atom donates one of its two 2p electrons into a delocalised pi system. A toxic, flammable liquid byproduct of coal distillation, it is used as an industrial solvent. Benzene is a carcinogen that also damages bone marrow and the central nervous system.	PMID:11993966|PMID:18836923|PMID:14677922|CAS:71-43-2|HMDB:HMDB0001505|PMID:18407866|PMID:21325737|PMID:16161967|PMID:15468289|PMID:18072742|PMID:11684179|Beilstein:969212|Wikipedia:Benzene|Reaxys:969212|PDBeChem:BNZ|PMID:12857942|KEGG:C01407|PMID:17373369|CAS:71-43-2|Gmelin:1671|PMID:23222815|PMID:19228219|PMID:23534829|PMID:6353911|UM-BBD_compID:c0142|PMID:23088855|PMID:15935818|PMID:18409691|CAS:71-43-2|PMID:8124204	hp.json	Phene|Benzine|Benzene|Benzen|Pyrobenzole|Pyrobenzol|phenyl hydride|BENZENE|benzene|benzene|benzole|Mineral naphtha|Benzol|cyclohexatriene|benzene|Bicarburet of hydrogen|[6]annulene|Coal naphtha	http://purl.obolibrary.org/obo/CHEBI_16716		3_STAR
HP:0410169	biolink:PhenotypicFeature	Abnormal morphology of the shoulder musculature	Any abnormality of the shoulder muscles.		hp.json	Muscle issues in the shoulder|Abnormality of the shoulder musculature	http://purl.obolibrary.org/obo/HP_0410169		
HP:0001982	biolink:PhenotypicFeature	Sea-blue histiocytosis	An abnormality of histiocytes, in which the cells take on a sea blue appearance due to abnormally increased lipid content. Histiocytes are a type of macrophage. Sea-blue histiocytes are typically large macrophages from 20 to 60 micrometers in diameter with a single eccentric nucleus whose cytoplasm if packed with sea-blue or blue-green granules when stained with Wright-Giemsa.	UMLS:C0036489|MSH:D012618|SNOMEDCT_US:37821003	hp.json	Sea-blue histiocyte	http://purl.obolibrary.org/obo/HP_0001982		
HP:0410168	biolink:PhenotypicFeature	Abnormality of the back musculature	Any abnormality of the back muscles.		hp.json	Muscle issues in the back	http://purl.obolibrary.org/obo/HP_0410168		
HP:0001980	biolink:PhenotypicFeature	Megaloblastic bone marrow	Abnormal increased number of megaloblasts in the bone marrow.	SNOMEDCT_US:167921008|UMLS:C0238801	hp.json		http://purl.obolibrary.org/obo/HP_0001980		
HP:0410167	biolink:PhenotypicFeature	Abnormal morphology of the chest musculature	Any abnormality of the chest muscles.		hp.json	Abnormality of the chest musculature|Muscle issues in the chest	http://purl.obolibrary.org/obo/HP_0410167		
HP:0001985	biolink:PhenotypicFeature	Hypoketotic hypoglycemia	A decreased concentration of glucose in the blood associated with a reduced concentration of ketone bodies.	UMLS:C1856438	hp.json	Hypoglycemia, hypoketotic	http://purl.obolibrary.org/obo/HP_0001985		
HP:0001986	biolink:PhenotypicFeature	Hypertonic dehydration		UMLS:C1112601	hp.json	Hyperosmolar dehydration	http://purl.obolibrary.org/obo/HP_0001986		
HP:0001983	biolink:PhenotypicFeature	Reduced lymphocyte surface expression of CD43	A reduction in the expression of CD43 on the cell surface of lymphocytes.	UMLS:C4021766	hp.json	Reduced lymphocyte surface expression of sialophorin|Cd43 defectively expressed on surface of blood cells	http://purl.obolibrary.org/obo/HP_0001983		
HP:0001984	biolink:PhenotypicFeature	Intolerance to protein		UMLS:C1396243	hp.json		http://purl.obolibrary.org/obo/HP_0001984		
HP:0011315	biolink:PhenotypicFeature	Unicoronal synostosis	Synostosis affecting only one of the coronal sutures.	UMLS:C4023418|UMLS:C4020756	hp.json	Unilateral coronal suture synostosis|Unilateral coronal craniosynostosis|Unilateral coronal suture craniosynostosis	http://purl.obolibrary.org/obo/HP_0011315		
HP:0011316	biolink:PhenotypicFeature	Left unicoronal synostosis	Synostosis affecting only the left coronal suture.	UMLS:C4023417	hp.json		http://purl.obolibrary.org/obo/HP_0011316		
HP:0011317	biolink:PhenotypicFeature	Right unicoronal synostosis	Unicoronal synostosis affecting only the right coronal suture.	UMLS:C4023416	hp.json		http://purl.obolibrary.org/obo/HP_0011317		
HP:0011318	biolink:PhenotypicFeature	Bicoronal synostosis	Synostosis affecting the right and the left coronal suture.	UMLS:C4021164	hp.json	Bilateral coronal craniosynostosis|Bilateral coronal suture craniosynostosis|Bilateral coronal suture synostosis	http://purl.obolibrary.org/obo/HP_0011318		hposlim_core
HP:0011319	biolink:PhenotypicFeature	Bilambdoid synostosis	Premature synostosis of both lambdoid sutures.	UMLS:C4021163	hp.json	Bilateral lambdoid craniosynostosis|Bilateral lambdoid suture synostosis	http://purl.obolibrary.org/obo/HP_0011319		hposlim_core
HP:0410166	biolink:PhenotypicFeature	Defective interstrand cross-link repair	A defect in the of the process of interstrand cross-link repair: removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.		hp.json		http://purl.obolibrary.org/obo/HP_0410166		
HP:0011300	biolink:PhenotypicFeature	Broad fingertip	Increased width of the distal segment of a finger.	UMLS:C1968816	hp.json	Broad fingertips|Broad fingertip	http://purl.obolibrary.org/obo/HP_0011300		hposlim_core
HP:0011301	biolink:PhenotypicFeature	Absent foot	The total absence of the foot, with no bony elements distal to the tibia or fibula.	UMLS:C0265624|SNOMEDCT_US:371197005	hp.json	Aplasia of the foot|Absent foot|Apodia	http://purl.obolibrary.org/obo/HP_0011301		hposlim_core
HP:0011302	biolink:PhenotypicFeature	Long palm	For children from birth to 16 years of age the length of the palm is more than the 97th centile; or, the length of the palm appears relatively long compared to the finger length or the limb length.	UMLS:C4023422	hp.json	Long palm	http://purl.obolibrary.org/obo/HP_0011302		hposlim_core
HP:0011303	biolink:PhenotypicFeature	Convex contour of sole	The contour of the foot in lateral profile has a convex shape.	UMLS:C4023421	hp.json		http://purl.obolibrary.org/obo/HP_0011303		
HP:0001998	biolink:PhenotypicFeature	Neonatal hypoglycemia		UMLS:C0158986|SNOMEDCT_US:52767006	hp.json	Low blood sugar in newborn	http://purl.obolibrary.org/obo/HP_0001998		
HP:0001999	biolink:PhenotypicFeature	Abnormal facial shape	An abnormal morphology (form) of the face or its components.	SNOMEDCT_US:398302004|UMLS:C0424503|UMLS:C4072833|SNOMEDCT_US:32003007|UMLS:C1385263|UMLS:C4072832|SNOMEDCT_US:398206004|SNOMEDCT_US:248200007|UMLS:C0266617	hp.json	Facial dysmorphism|Abnormal facial shape|Deformity of face|Malformation of face|Unusual facial appearance|Distortion of face|Unusual facies|Dysmorphic facial features|Dysmorphic facies|Distinctive facies|Funny looking face|Abnormal morphology of the face	http://purl.obolibrary.org/obo/HP_0001999		hposlim_core
CHEBI:16708	biolink:ChemicalSubstance	adenine	The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.	PMID:12829005|MetaCyc:ADENINE|KEGG:C00147|Wikipedia:Adenine|DrugBank:DB00173|Drug_Central:89|Gmelin:3903|Beilstein:608603|PMID:15715490|Reaxys:608603|KEGG:D00034|PMID:17439666|PDBeChem:ADE|PMID:12951489|KNApSAcK:C00001490|CAS:73-24-5|PMID:15063338|PMID:11985597|PMID:8070089|HMDB:HMDB0000034|CAS:73-24-5|CAS:73-24-5	hp.json	ADENINE|Ade|Adenin|adenine|9H-purin-6-amine|A|6-Aminopurine|Adenine	http://purl.obolibrary.org/obo/CHEBI_16708		3_STAR
HP:0001992	biolink:PhenotypicFeature	Organic aciduria	Excretion of non-amino organic acids in urine.	UMLS:C0241775	hp.json		http://purl.obolibrary.org/obo/HP_0001992		
HP:0001993	biolink:PhenotypicFeature	Ketoacidosis	Acidosis resulting from accumulation of ketone bodies.	UMLS:C0220982|SNOMEDCT_US:56051008	hp.json		http://purl.obolibrary.org/obo/HP_0001993		
HP:0410158	biolink:PhenotypicFeature	obsolete Increased urine O-phosphoethanolamine level			hp.json	Increased level of O-phosphoethanolamine in urine	http://purl.obolibrary.org/obo/HP_0410158		
HP:0410157	biolink:PhenotypicFeature	Increased level of N-acetylneuraminic acid in fibroblasts	An increase in the level of N-acetylneuraminic acid in cultured fibroblasts.		hp.json	Increased level of sialic acid in fibroblasts|Increased level of NANA in fibroblasts|Increased level of Neu5Ac in fibroblasts	http://purl.obolibrary.org/obo/HP_0410157		
HP:0410156	biolink:PhenotypicFeature	Increased level of N-acetylneuraminic acid in urine	An increase in the level of N-acetylneuraminic acid in the urine.		hp.json	Increased level of NANA in urine|Increased level of Neu5Ac in urine	http://purl.obolibrary.org/obo/HP_0410156		
HP:0001991	biolink:PhenotypicFeature	Aplasia/Hypoplasia of toe	Absence or hypoplasia of toes.	UMLS:C3551148	hp.json	Absent/hypoplastic toes|Absent/small toe|Aplastic/hypoplastic toe phalanges|Absent/underdeveloped toe	http://purl.obolibrary.org/obo/HP_0001991		
HP:0001996	biolink:PhenotypicFeature	Chronic metabolic acidosis	Longstanding metabolic acidosis.	UMLS:C0740749	hp.json		http://purl.obolibrary.org/obo/HP_0001996		
HP:0001997	biolink:PhenotypicFeature	Gout	Recurrent attacks of acute inflammatory arthritis of a joint or set of joints caused by elevated levels of uric acid in the blood which crystallize and are deposited in joints, tendons, and surrounding tissues.	SNOMEDCT_US:190828008|SNOMEDCT_US:48440001|MSH:D015210|SNOMEDCT_US:90560007|SNOMEDCT_US:170733007|MSH:D006073|UMLS:C0018099|UMLS:C0003868	hp.json	Gouty arthritis	http://purl.obolibrary.org/obo/HP_0001997		
HP:0001994	biolink:PhenotypicFeature	Renal Fanconi syndrome	An inability of the tubules in the kidney to reabsorb small molecules, causing increased urinary loss of electrolytes (sodium, potassium, bicarbonate), minerals, glucose, amino acids, and water.	SNOMEDCT_US:44673006|MSH:D005198|UMLS:C0341703|SNOMEDCT_US:236468006	hp.json	Renal tubular fanconi syndrome|De toni-fanconi-debre syndrome	http://purl.obolibrary.org/obo/HP_0001994		
HP:0001995	biolink:PhenotypicFeature	Hyperchloremic acidosis	Acidosis (pH less than 7.35) that develops with an increase in ionic chloride.	SNOMEDCT_US:18104000|UMLS:C0085569	hp.json		http://purl.obolibrary.org/obo/HP_0001995		
HP:0011304	biolink:PhenotypicFeature	Broad thumb	Increased thumb width without increased dorso-ventral dimension.	SNOMEDCT_US:249773003|UMLS:C0426891	hp.json	Wide/broad thumb|Wide/broad thumb phalanges|Broad thumbs|Broad thumb|Broad phalanges of the thumb	http://purl.obolibrary.org/obo/HP_0011304		hposlim_core
HP:0410151	biolink:PhenotypicFeature	Eosinophilic infiltration of the esophagus	Infiltration of numerous eosinophils (usually greater than 15 per high power field) into the squamous epithelium of the esophagus, and layering of eosinophils on the surface layer of the esophagus.		hp.json	Eosinophilic infiltration of the oesophagus|Eosinophilic esophagitis	http://purl.obolibrary.org/obo/HP_0410151		
HP:0011305	biolink:PhenotypicFeature	Partial absence of toe	The absence of a phalangeal segment of a toe or hallux.	UMLS:C4021169	hp.json	Partial absence of toe|Hypophalangy of toes	http://purl.obolibrary.org/obo/HP_0011305		
HP:0011307	biolink:PhenotypicFeature	Splayed toes	Divergence of digits along the anteroposterior axis (in the plane of the sole).	UMLS:C2117390	hp.json	Splayed toes	http://purl.obolibrary.org/obo/HP_0011307		
HP:0011308	biolink:PhenotypicFeature	Slender toe	Toes that are disproportionately narrow (reduced girth) for the hand/foot size or build of the individual.	UMLS:C4021168	hp.json	Slender toe|Narrow toe	http://purl.obolibrary.org/obo/HP_0011308		
HP:0410154	biolink:PhenotypicFeature	Increased level of myristic acid in serum	An increase in the level of myristic acid in the serum.		hp.json	Increased level of tetradecanoic acid in serum	http://purl.obolibrary.org/obo/HP_0410154		
HP:0011309	biolink:PhenotypicFeature	Tapered toe	The gradual reduction in girth of the toe from proximal to distal.	UMLS:C4021167	hp.json	Tapered toe|Tapering toes	http://purl.obolibrary.org/obo/HP_0011309		
HP:0410153	biolink:PhenotypicFeature	Increased level of methylsuccinic acid in urine	An increase in the level of methylsuccinic acid in the urine.		hp.json	Increased level of pyrotartaric acid in urine	http://purl.obolibrary.org/obo/HP_0410153		
HP:0410152	biolink:PhenotypicFeature	Eosinophilic microabscess formation in the esophagus	The formation of small localized collection of eosinophiles (an eosinophilic microabscess) in the esophagus. Usually clusters of greater than or equal to 4 eosinophils are seen, that appear as exudates or white spots or white plaques.		hp.json	Eosinophilic microabscess formation in the oesophagus|Eosinophilic micro-abscess formation in the esophagus|Eosinophilic micro-abscess formation in the oesophagus	http://purl.obolibrary.org/obo/HP_0410152		
HP:0410191	biolink:PhenotypicFeature	Increased glucose-6-phosphate dehydrogenase level in leukocytes	An increase in the level of glucose-6-phosphate dehydrogenase in leukocytes.		hp.json	Increased G6PD level in leukocytes	http://purl.obolibrary.org/obo/HP_0410191		
HP:0410190	biolink:PhenotypicFeature	Decreased glucose-6-phosphate dehydrogenase level in leukocytes	A decrease in the level of glucose-6-phosphate dehydrogenase in leukocytes.		hp.json	Decreased G6PD level in leukocytes	http://purl.obolibrary.org/obo/HP_0410190		
GO:1905521	biolink:BiologicalProcess	regulation of macrophage migration	Any process that modulates the frequency, rate or extent of macrophage migration.		hp.json		http://purl.obolibrary.org/obo/GO_1905521		
GO:1905522	biolink:BiologicalProcess	negative regulation of macrophage migration	Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration.		hp.json	down regulation of macrophage migration|inhibition of macrophage migration|down-regulation of macrophage migration|downregulation of macrophage migration	http://purl.obolibrary.org/obo/GO_1905522		
GO:1905523	biolink:BiologicalProcess	positive regulation of macrophage migration	Any process that activates or increases the frequency, rate or extent of macrophage migration.		hp.json	upregulation of macrophage migration|up regulation of macrophage migration|up-regulation of macrophage migration|activation of macrophage migration	http://purl.obolibrary.org/obo/GO_1905523		
HP:0410189	biolink:PhenotypicFeature	Increased glucose-6-phosphate dehydrogenase level in red blood cells	An increase in the level of glucose-6-phosphate dehydrogenase in red blood cells.		hp.json	Increased G6PD level in red blood cells|Increased G6PD level in RBCs	http://purl.obolibrary.org/obo/HP_0410189		
UBERON:0035956	biolink:AnatomicalEntity	epididymal lumen	The lumen of the epididymis.	FMA:18274	hp.json	lumen of epididymis|epididymis lumen	http://purl.obolibrary.org/obo/UBERON_0035956		
HP:0410184	biolink:PhenotypicFeature	Abnormal glucose-6-phosphate dehydrogenase level in red blood cells	An anomaly in the level of glucose-6-phosphate dehydrogenase in red blood cells.		hp.json	Abnormal G6PD level in RBCs|Abnormal G6PD level in red blood cells	http://purl.obolibrary.org/obo/HP_0410184		
HP:0410183	biolink:PhenotypicFeature	Abnormal glucose-6-phosphate dehydrogenase level in leukocytes	An anomaly in the level of glucose-6-phosphate dehydrogenase in leukocytes.		hp.json	Abnormal G6PD level in leukocytes	http://purl.obolibrary.org/obo/HP_0410183		
UBERON:0008340	biolink:AnatomicalEntity	nasal bridge	A saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canth[WP].	MA:0002874	hp.json		http://purl.obolibrary.org/obo/UBERON_0008340		pheno_slim
HP:0410182	biolink:PhenotypicFeature	Decreased glucose-6-phosphate dehydrogenase level in dried blood spot	A decrease in the level of glucose-6-phosphate dehydrogenase in a dried blood spot.		hp.json	Decreased G6PD level in dried blood spot|Decreased glucose-6-phosphate dehydrogenase level in DBS	http://purl.obolibrary.org/obo/HP_0410182		
UBERON:0008341	biolink:AnatomicalEntity	columella nasi	The tissue that links the nasal tip to the nasal base, and separates the nares. It is the inferior margin of the nasal septum[EoM].	EMAPA:37832|FMA:59725	hp.json	columella of nose|nasal columella|columella	http://purl.obolibrary.org/obo/UBERON_0008341		pheno_slim
HP:0410181	biolink:PhenotypicFeature	Increased glucose-6-phosphate dehydrogenase level in dried blood spot	An increase in the level of glucose-6-phosphate dehydrogenase in a dried blood spot.		hp.json	Increased glucose-6-phosphate dehydrogenase level in DBS|Increased G6PD level in dried blood spot	http://purl.obolibrary.org/obo/HP_0410181		
UBERON:0008342	biolink:AnatomicalEntity	intestinal villus of duodenum	An intestinal villus in the duodenum.	FMA:63300	hp.json		http://purl.obolibrary.org/obo/UBERON_0008342		
HP:0410188	biolink:PhenotypicFeature	Decreased glucose-6-phosphate dehydrogenase level in red blood cells	A decrease in the level of glucose-6-phosphate dehydrogenase in red blood cells.		hp.json	Decreased G6PD level in RBCs|Decreased G6PD level in red blood cells	http://purl.obolibrary.org/obo/HP_0410188		
UBERON:0008343	biolink:AnatomicalEntity	intestinal villus of jejunum	An intestinal villus in the jejunum.	FMA:63301	hp.json		http://purl.obolibrary.org/obo/UBERON_0008343		
HP:0410187	biolink:PhenotypicFeature	Decreased glucose-6-phosphate dehydrogenase level in tissue	A decrease in the level of glucose-6-phosphate dehydrogenase in tissue.		hp.json	Decreased G6PD level in tissue	http://purl.obolibrary.org/obo/HP_0410187		
UBERON:0008344	biolink:AnatomicalEntity	intestinal villus of ileum	An intestinal villus in the ileum.	FMA:63302	hp.json		http://purl.obolibrary.org/obo/UBERON_0008344		
UBERON:0008345	biolink:AnatomicalEntity	ileal epithelium	An epithelium that is part of a ileum.	EMAPA:35423|MA:0003217|FMA:17233	hp.json	epithelium of ileum	http://purl.obolibrary.org/obo/UBERON_0008345		
HP:0410186	biolink:PhenotypicFeature	Increased glucose-6-phosphate dehydrogenase level in tissue	An increase in the level of glucose-6-phosphate dehydrogenase in tissue.		hp.json	Increased G6PD level in tissue	http://purl.obolibrary.org/obo/HP_0410186		
UBERON:0008346	biolink:AnatomicalEntity	duodenal epithelium	An epithelium that is part of a duodenum.	MA:0003208|CALOHA:TS-2087|FMA:17231|EMAPA:19078	hp.json	epithelium of duodenum	http://purl.obolibrary.org/obo/UBERON_0008346		human_reference_atlas
HP:0410185	biolink:PhenotypicFeature	Abnormal glucose-6-phosphate dehydrogenase level in tissue	An anomaly in the level of glucose-6-phosphate dehydrogenase in tissue.		hp.json	Abnormal G6PD level in tissue	http://purl.obolibrary.org/obo/HP_0410185		
HP:0410180	biolink:PhenotypicFeature	Abnormal glucose-6-phosphate dehydrogenase level in dried blood spot	An anomaly in the level of glucose-6-phosphate dehydrogenase in a dried blood spot.		hp.json	Abnormal G6PD level in dried blood spot|Abnormal glucose-6-phosphate dehydrogenase level in DBS	http://purl.obolibrary.org/obo/HP_0410180		
GO:0051128	biolink:BiologicalProcess	regulation of cellular component organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.		hp.json	regulation of cell organization|regulation of cellular component organisation|regulation of cell organisation|regulation of cellular component organization and biogenesis	http://purl.obolibrary.org/obo/GO_0051128		
GO:0051129	biolink:BiologicalProcess	negative regulation of cellular component organization	Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.		hp.json	down-regulation of cell organization|negative regulation of cellular component organization and biogenesis|negative regulation of cell organisation|down regulation of cell organization|inhibition of cell organization|downregulation of cell organization	http://purl.obolibrary.org/obo/GO_0051129		
UBERON:0011980	biolink:AnatomicalEntity	crurotarsal joint	A joint that connects the bones of the crus to the proximal tarsal bones.		hp.json	crurotarsal	http://purl.obolibrary.org/obo/UBERON_0011980		
CHEBI:26155	biolink:ChemicalSubstance	plant growth regulator	A chemical, natural or artificial, that can affect the rate of growth of a plant.		hp.json	plant growth regulators	http://purl.obolibrary.org/obo/CHEBI_26155		3_STAR
UBERON:0011977	biolink:AnatomicalEntity	epiphysis of proximal phalanx of manus	An epiphysis that is part of a proximal phalanx of manus.		hp.json	epiphysis of proximal phalanx of finger	http://purl.obolibrary.org/obo/UBERON_0011977		pheno_slim
UBERON:0011976	biolink:AnatomicalEntity	epiphysis of distal phalanx of pes	An epiphysis that is part of a distal phalanx of pes.		hp.json	epiphysis of distal phalanx of toe	http://purl.obolibrary.org/obo/UBERON_0011976		
UBERON:0035965	biolink:AnatomicalEntity	wall of blood vessel		FMA:67473|EMAPA:37987|BTO:0004378	hp.json	blood vessel wall|vascular wall	http://purl.obolibrary.org/obo/UBERON_0035965		
HP:0410179	biolink:PhenotypicFeature	Decreased glucose-6-phosphate dehydrogenase level in blood	A decrease in the level of glucose-6-phosphate dehydrogenase in the blood.		hp.json	Decreased G6PD level in blood	http://purl.obolibrary.org/obo/HP_0410179		
UBERON:0008338	biolink:AnatomicalEntity	plantar part of pes	The sole is the bottom of the foot.	galen:SoleOfFoot|CALOHA:TS-0379|UMLS:C0230463|BTO:0005078|NCIT:C33326|FMA:25000	hp.json	regio plantaris|sole|soles of the feet|plantar part of foot|sole of foot|planta|planta|sole of foot|sole of the foot|pelma|plantar region	http://purl.obolibrary.org/obo/UBERON_0008338		pheno_slim
UBERON:0011975	biolink:AnatomicalEntity	epiphysis of middle phalanx of pes	An epiphysis that is part of a middle phalanx of pes.		hp.json	epiphysis of middle phalanx of toe	http://purl.obolibrary.org/obo/UBERON_0011975		
HP:0410178	biolink:PhenotypicFeature	Increased glucose-6-phosphate dehydrogenase level in blood	An increase in the level of glucose-6-phosphate dehydrogenase in the blood.		hp.json	Increased G6PD level in blood	http://purl.obolibrary.org/obo/HP_0410178		
UBERON:0008339	biolink:AnatomicalEntity	microvascular endothelium		BTO:0003122	hp.json		http://purl.obolibrary.org/obo/UBERON_0008339		
UBERON:0011974	biolink:AnatomicalEntity	epiphysis of proximal phalanx of pes	An epiphysis that is part of a proximal phalanx of pes.		hp.json	epiphysis of proximal phalanx of toe	http://purl.obolibrary.org/obo/UBERON_0011974		
UBERON:0011979	biolink:AnatomicalEntity	epiphysis of distal phalanx of manus	An epiphysis that is part of a distal phalanx of manus.	FMA:321561	hp.json	epiphysis of distal phalanx of finger	http://purl.obolibrary.org/obo/UBERON_0011979		
UBERON:0011978	biolink:AnatomicalEntity	epiphysis of middle phalanx of manus	An epiphysis that is part of a middle phalanx of manus.		hp.json	epiphysis of middle phalanx of finger	http://purl.obolibrary.org/obo/UBERON_0011978		
HP:0410173	biolink:PhenotypicFeature	Increased circulating troponin I concentration	An increased concentration of tropnin I in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction.		hp.json	Increased troponin I level in blood	http://purl.obolibrary.org/obo/HP_0410173		
HP:0410172	biolink:PhenotypicFeature	Blood xenobiotic	The presence of a xenobiotic in blood.		hp.json		http://purl.obolibrary.org/obo/HP_0410172		
HP:0410171	biolink:PhenotypicFeature	Increased cotinine level	Increased concentration of cotinine in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410171		
UBERON:0008331	biolink:AnatomicalEntity	clitoral smooth muscle	A smooth muscle tissue that is part of a clitoris.	BTO:0005000	hp.json	clitoris smooth muscle	http://purl.obolibrary.org/obo/UBERON_0008331		
HP:0410170	biolink:PhenotypicFeature	Hippocampal atrophy	Partial or complete wasting (loss) of hippocampus tissue that was once present.		hp.json	Atrophy of the hippocampus|Degeneration of the hippocampus	http://purl.obolibrary.org/obo/HP_0410170		
HP:0410177	biolink:PhenotypicFeature	Abnormal glucose-6-phosphate dehydrogenase level in blood	An anomaly in the level of glucose-6-phosphate dehydrogenase in the blood.		hp.json	Abnormal G6PD level in blood	http://purl.obolibrary.org/obo/HP_0410177		
HP:0410176	biolink:PhenotypicFeature	Abnormal glucose-6-phosphate dehydrogenase level	An anomaly in the level of glucose-6-phosphate dehydrogenase.		hp.json	Abnormal G6PD level	http://purl.obolibrary.org/obo/HP_0410176		
HP:0410175	biolink:PhenotypicFeature	Hyperketonemia	An increase in the level of ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone) in the blood.		hp.json	Increased level of ketone bodies in blood|Elevated circulating ketone body concentration|Ketonemia	http://purl.obolibrary.org/obo/HP_0410175		
HP:0410174	biolink:PhenotypicFeature	Increased circulating troponin T concentration	An increased concentration of tropnin T in the blood, which is a cardiac regulatory protein that controls the calcium mediated interaction between actin and myosin. Raised cardiac troponin concentrations are now accepted as the standard biochemical marker for the diagnosis of myocardial infarction.		hp.json	Increased troponin T level in blood	http://purl.obolibrary.org/obo/HP_0410174		
CHEBI:28789	biolink:ChemicalSubstance	L-glucitol	The L-enantiomer of glucitol.	Reaxys:1721906|Beilstein:1721906|CAS:6706-59-8|YMDB:YMDB00724|CAS:6706-59-8|MetaCyc:CPD-12810|Gmelin:648560|ECMDB:ECMDB00247|PMID:19695255|KEGG:C01722	hp.json	L-glucitol|D-gulitol|L-Sorbitol|(2R,3S,4S,5S)-hexane-1,2,3,4,5,6-hexol|L-Glucitol|L-sorbitol|D-Gulitol|L-glucitol|L-glucitol	http://purl.obolibrary.org/obo/CHEBI_28789		3_STAR
UBERON:0011973	biolink:AnatomicalEntity	epiphysis of phalanx of pes	An epiphysis that is part of a phalanx of a pes [Automatically generated definition].		hp.json	epiphysis of phalanx of toe	http://purl.obolibrary.org/obo/UBERON_0011973		
UBERON:0011972	biolink:AnatomicalEntity	medial ligament of ankle joint	A skeletal ligament that connects a tibia and connects a tarsal skeleton.	FMA:44055	hp.json	ligamentum deltoideum (articulatio talocruralis)|deltoid collateral ligament of ankle joint|ligamentum collaterale mediale (articulatio talocruralis)|deltoid ligament of ankle joint|ligamentum collaterale mediale articulationis talocruralis|medial collateral ligament of ankle joint|ligamentum deltoideum	http://purl.obolibrary.org/obo/UBERON_0011972		
UBERON:0011971	biolink:AnatomicalEntity	calcaneofibular ligament	A skeletal ligament that connects the fibula to the calcaneus.	FMA:44089	hp.json	ligamentum calcaneofibulare	http://purl.obolibrary.org/obo/UBERON_0011971		
GO:1905553	biolink:BiologicalProcess	regulation of blood vessel branching	Any process that modulates the frequency, rate or extent of blood vessel branching.		hp.json	regulation of branching involved in blood vessel morphogenesis	http://purl.obolibrary.org/obo/GO_1905553		
UBERON:0011970	biolink:AnatomicalEntity	talofibular ligament	A skeletal ligament that connects the fibula to the talus. Examples: anterior and posterior talofibular ligament.	FMA:44080	hp.json	talo-fibular ligament|ligamentum talofibulare	http://purl.obolibrary.org/obo/UBERON_0011970		
UBERON:0011965	biolink:AnatomicalEntity	saddle joint	In a saddle joint (sellar joint, articulation by reciprocal reception) the opposing surfaces are reciprocally concave-convex.	FMA:75298	hp.json	articulation by reciprocal reception|sellar joint	http://purl.obolibrary.org/obo/UBERON_0011965		
UBERON:0011964	biolink:AnatomicalEntity	calcaneocuboid joint	Calcaneocuboid Articulation (articulation of the calcaneus with the cuboid). The ligaments connecting the calcaneus with the cuboid are five in number, viz. , the articular capsule, the dorsal calcaneocuboid, part of the bifurcated, the long plantar, and the plantar calcaneocuboid.	FMA:35207	hp.json	calcaneocuboid articulation|articulatio calcaneocubiodea|calcaneocuboidal joint	http://purl.obolibrary.org/obo/UBERON_0011964		
UBERON:0011963	biolink:AnatomicalEntity	talocalcaneonavicular joint	The talocalcaneonavicular articulation is an arthrodial joint: the rounded head of the talus being received into the concavity formed by the posterior surface of the navicular, the anterior articular surface of the calcaneus, and the upper surface of the plantar calcaneonavicular ligament. There are two ligaments in this joint: the articular capsule and the dorsal talonavicular.	FMA:35204	hp.json	talocalcaneonavicular articulation|articulatio talocalcaneonavicularis	http://purl.obolibrary.org/obo/UBERON_0011963		
CHEBI:38104	biolink:ChemicalSubstance	oxacycle	Any organic heterocyclic compound containing at least one ring oxygen atom.	PMID:17134300	hp.json	organooxygen heterocyclic compounds|oxacycles|heterocyclic organooxygen compounds	http://purl.obolibrary.org/obo/CHEBI_38104		3_STAR
UBERON:0011969	biolink:AnatomicalEntity	mesotarsal joint	An ankle joint that passes between the proximal and distal tarsals.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011969		
UBERON:0011968	biolink:AnatomicalEntity	radio-carpal joint	A skeletal joint that connects a radius bone and connects a carpal skeleton.	EMAPA:19205|MA:0000461|FMA:35291	hp.json	wrist joint|radiocarpal articulation|radiocarpal joint|articulatio radiocarpea	http://purl.obolibrary.org/obo/UBERON_0011968		
GO:0051130	biolink:BiologicalProcess	positive regulation of cellular component organization	Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.		hp.json	positive regulation of cellular component organization and biogenesis|positive regulation of cell organisation|up-regulation of cell organization|up regulation of cell organization|activation of cell organization|stimulation of cell organization|upregulation of cell organization	http://purl.obolibrary.org/obo/GO_0051130		
UBERON:0008320	biolink:AnatomicalEntity	common penile artery	The artery that serves blood to the penis. It subdivides into three arteries, the bulbourethral artery, the dorsal artery of the penis and the cavernosal artery.	BTO:0005085|FMA:66318	hp.json	artery of penis|penile artery	http://purl.obolibrary.org/obo/UBERON_0008320		human_reference_atlas
UBERON:0008321	biolink:AnatomicalEntity	deep artery of penis	The deep artery of the penis (artery to the corpus cavernosum), one of the terminal branches of the internal pudendal, arises from that vessel while it is situated between the two fascia of the urogenital diaphragm (deep perineal pouch). It pierces the inferior fascia, and, entering the crus penis obliquely, runs forward in the center of the corpus cavernosum penis, to which its branches are distributed.	BTO:0005086|FMA:19794	hp.json	arteria profunda penis|deep penile artery|cavernosal artery|arteria cavernosa penis|arteria profunda penis	http://purl.obolibrary.org/obo/UBERON_0008321		
UBERON:0008322	biolink:AnatomicalEntity	deep artery of clitoris	The deep artery of clitoris is a branch of the internal pudendal artery.	FMA:20870	hp.json	arteria profunda clitoridis	http://purl.obolibrary.org/obo/UBERON_0008322		human_reference_atlas
CHEBI:38101	biolink:ChemicalSubstance	organonitrogen heterocyclic compound	Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms.		hp.json	heterocyclic organonitrogen compounds|organonitrogen heterocyclic compounds	http://purl.obolibrary.org/obo/CHEBI_38101		3_STAR
UBERON:0008324	biolink:AnatomicalEntity	erectile tissue	With numerous vascular spaces that may become engorged with blood.		hp.json		http://purl.obolibrary.org/obo/UBERON_0008324		
GO:0051148	biolink:BiologicalProcess	negative regulation of muscle cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.		hp.json	inhibition of muscle cell differentiation|downregulation of muscle cell differentiation|down-regulation of muscle cell differentiation|down regulation of muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0051148		
GO:0051149	biolink:BiologicalProcess	positive regulation of muscle cell differentiation	Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.		hp.json	up-regulation of muscle cell differentiation|up regulation of muscle cell differentiation|activation of muscle cell differentiation|stimulation of muscle cell differentiation|upregulation of muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0051149		
GO:0051146	biolink:BiologicalProcess	striated muscle cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.		hp.json	voluntary muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0051146		
GO:0051147	biolink:BiologicalProcess	regulation of muscle cell differentiation	Any process that modulates the frequency, rate or extent of muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0051147		
UBERON:0011962	biolink:AnatomicalEntity	transverse tarsal joint	The transverse tarsal joint is formed by the articulation of the calcaneus with the cuboid, and the articulation of the talus with the navicular. The movement which takes place in this joint is more extensive than that in the other tarsal joints, and consists of a sort of rotation by means of which the foot may be slightly flexed or extended, the sole being at the same time carried medially (inverted) or laterally.	FMA:35201|NCIT:C102354	hp.json	chopart's joint|articulatio tarsi transversa|midtarsal joint	http://purl.obolibrary.org/obo/UBERON_0011962		
CHEBI:28790	biolink:ChemicalSubstance	serotonin	A primary amino compound that is the 5-hydroxy derivative of tryptamine.	HMDB:HMDB0000259|KEGG:C00780|Beilstein:143524|KNApSAcK:C00001429|PDBeChem:SRO|Reaxys:143524|CAS:50-67-9|Gmelin:1861995|CAS:50-67-9|MetaCyc:SEROTONIN|Wikipedia:Serotonin|PMID:22770225|PMID:24136337|LINCS:LSM-6589|PMID:18593914	hp.json	5-HT|Serotonin|5-Hydroxytryptamine|thrombotonin|Enteramine|3-(2-aminoethyl)-1H-indol-5-ol|SEROTONIN|thrombocytin|serotonine|3-(2-Aminoethyl)-1H-indol-5-ol	http://purl.obolibrary.org/obo/CHEBI_28790		3_STAR
GO:1905562	biolink:BiologicalProcess	regulation of vascular endothelial cell proliferation	Any process that modulates the frequency, rate or extent of vascular endothelial cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_1905562		
UBERON:0011961	biolink:AnatomicalEntity	articular capsule of hip joint	An articular capsule that is part of the hip joint.	FMA:42821	hp.json	capsule of hip joint|fibrous capsule of hip joint|capsula articularis coxae	http://purl.obolibrary.org/obo/UBERON_0011961		
GO:1905563	biolink:BiologicalProcess	negative regulation of vascular endothelial cell proliferation	Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation.		hp.json	inhibition of vascular endothelial cell proliferation|downregulation of vascular endothelial cell proliferation|down-regulation of vascular endothelial cell proliferation|down regulation of vascular endothelial cell proliferation	http://purl.obolibrary.org/obo/GO_1905563		
UBERON:0011960	biolink:AnatomicalEntity	articular capsule of glenohumeral joint	An articular capsule that is part of the glenohumeral joint.	FMA:34944	hp.json	glenohumeral joint capsule|articular capsule of humerus|fibrous capsule of glenohumeral joint|capsule of shoulder joint|articular capsule of shoulder joint	http://purl.obolibrary.org/obo/UBERON_0011960		
GO:1905564	biolink:BiologicalProcess	positive regulation of vascular endothelial cell proliferation	Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.		hp.json	up-regulation of vascular endothelial cell proliferation|up regulation of vascular endothelial cell proliferation|activation of vascular endothelial cell proliferation|upregulation of vascular endothelial cell proliferation	http://purl.obolibrary.org/obo/GO_1905564		
UBERON:0011955	biolink:AnatomicalEntity	left hepatic vein	A hepatic vein that is part of a left lobe of liver.	MA:0003032|FMA:14339|EMAPA:37164	hp.json		http://purl.obolibrary.org/obo/UBERON_0011955		human_reference_atlas
GO:1905554	biolink:BiologicalProcess	negative regulation of vessel branching	Any process that stops, prevents or reduces the frequency, rate or extent of blood vessel branching.		hp.json	downregulation of branching involved in blood vessel morphogenesis|down regulation of branching involved in blood vessel morphogenesis|down-regulation of patterning of blood vessels|inhibition of branching involved in blood vessel morphogenesis|negative regulation of branching involved in blood vessel morphogenesis|down-regulation of branching involved in blood vessel morphogenesis|down regulation of patterning of blood vessels|downregulation of patterning of blood vessels|inhibition of patterning of blood vessels	http://purl.obolibrary.org/obo/GO_1905554		
GO:0090713	biolink:NamedThing	immunological memory process			hp.json		http://purl.obolibrary.org/obo/GO_0090713		
GO:1905555	biolink:BiologicalProcess	positive regulation of blood vessel branching	Any process that activates or increases the frequency, rate or extent of blood vessel branching.		hp.json	up regulation of patterning of blood vessels|up-regulation of branching involved in blood vessel morphogenesis|activation of branching involved in blood vessel morphogenesis|activation of patterning of blood vessels|upregulation of patterning of blood vessels|upregulation of branching involved in blood vessel morphogenesis|positive regulation of branching involved in blood vessel morphogenesis|up-regulation of patterning of blood vessels|up regulation of branching involved in blood vessel morphogenesis	http://purl.obolibrary.org/obo/GO_1905555		
UBERON:0011953	biolink:AnatomicalEntity	stomach glandular region	A region of the stomach that is lined with glandular epithelium.	UMLS:C0227197|MA:0001613|EMAPA:17623|SCTID:27633001|NCIT:C77661	hp.json	glandular stomach	http://purl.obolibrary.org/obo/UBERON_0011953		pheno_slim
GO:1905557	biolink:BiologicalProcess	regulation of mitotic nuclear envelope disassembly	Any process that modulates the frequency, rate or extent of mitotic nuclear envelope disassembly.		hp.json	regulation of mitotic nuclear envelope breakdown|regulation of mitotic nuclear envelope degradation|regulation of mitotic nuclear envelope catabolism	http://purl.obolibrary.org/obo/GO_1905557		
GO:1905558	biolink:BiologicalProcess	negative regulation of mitotic nuclear envelope disassembly	Any process that stops, prevents or reduces the frequency, rate or extent of mitotic nuclear envelope disassembly.		hp.json	inhibition of mitotic nuclear envelope catabolism|down regulation of mitotic nuclear envelope disassembly|negative regulation of mitotic nuclear envelope degradation|inhibition of mitotic nuclear envelope disassembly|downregulation of mitotic nuclear envelope catabolism|down-regulation of mitotic nuclear envelope degradation|down regulation of mitotic nuclear envelope breakdown|down-regulation of mitotic nuclear envelope disassembly|inhibition of mitotic nuclear envelope breakdown|down-regulation of mitotic nuclear envelope breakdown|negative regulation of mitotic nuclear envelope breakdown|negative regulation of mitotic nuclear envelope catabolism|downregulation of mitotic nuclear envelope degradation|down-regulation of mitotic nuclear envelope catabolism|downregulation of mitotic nuclear envelope disassembly|down regulation of mitotic nuclear envelope catabolism|down regulation of mitotic nuclear envelope degradation|inhibition of mitotic nuclear envelope degradation|downregulation of mitotic nuclear envelope breakdown	http://purl.obolibrary.org/obo/GO_1905558		
GO:1905559	biolink:BiologicalProcess	positive regulation of mitotic nuclear envelope disassembly	Any process that activates or increases the frequency, rate or extent of mitotic nuclear envelope disassembly.		hp.json	activation of mitotic nuclear envelope breakdown|upregulation of mitotic nuclear envelope degradation|up-regulation of mitotic nuclear envelope catabolism|upregulation of mitotic nuclear envelope disassembly|up regulation of mitotic nuclear envelope catabolism|positive regulation of mitotic nuclear envelope degradation|activation of mitotic nuclear envelope catabolism|upregulation of mitotic nuclear envelope breakdown|positive regulation of mitotic nuclear envelope catabolism|up regulation of mitotic nuclear envelope degradation|up regulation of mitotic nuclear envelope disassembly|up-regulation of mitotic nuclear envelope degradation|upregulation of mitotic nuclear envelope catabolism|positive regulation of mitotic nuclear envelope breakdown|activation of mitotic nuclear envelope degradation|up regulation of mitotic nuclear envelope breakdown|up-regulation of mitotic nuclear envelope disassembly|activation of mitotic nuclear envelope disassembly|up-regulation of mitotic nuclear envelope breakdown	http://purl.obolibrary.org/obo/GO_1905559		
GO:0090715	biolink:NamedThing	immunological memory formation process			hp.json		http://purl.obolibrary.org/obo/GO_0090715		
UBERON:0011956	biolink:AnatomicalEntity	right hepatic vein	A hepatic vein that is part of a right lobe of liver.	FMA:14338|EMAPA:37377|MA:0003034	hp.json		http://purl.obolibrary.org/obo/UBERON_0011956		human_reference_atlas
HP:0410195	biolink:PhenotypicFeature	Decreased uridine diphosphate glucose-4-epimerase level in plasma	A decrease in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.		hp.json	Decreased UDP-glucose 4-epimerase level in plasma	http://purl.obolibrary.org/obo/HP_0410195		
HP:0410194	biolink:PhenotypicFeature	Increased uridine diphosphate glucose-4-epimerase level in plasma	An increase in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.		hp.json	Increased UDP-glucose 4-epimerase level in plasma	http://purl.obolibrary.org/obo/HP_0410194		
HP:0410193	biolink:PhenotypicFeature	Abnormal uridine diphosphate glucose-4-epimerase level in plasma	An abnormality in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.		hp.json	Abnormal UDP-glucose 4-epimerase activity level in plasma	http://purl.obolibrary.org/obo/HP_0410193		
HP:0410192	biolink:PhenotypicFeature	Abnormal uridine diphosphate glucose-4-epimerase level	An abnormality in uridine diphosphate glucose-4-epimerase level, an enzyme that catalyzes the reaction: UDP-glucose = UDP-galactose.		hp.json	Abnormal UDP-glucose 4-epimerase level	http://purl.obolibrary.org/obo/HP_0410192		
UBERON:0008310	biolink:AnatomicalEntity	nasopharyngeal gland	A gland that is part of a nasopharynx.	FMA:55076	hp.json		http://purl.obolibrary.org/obo/UBERON_0008310		organ_slim
HP:0410199	biolink:PhenotypicFeature	Increased CSF urate concentration	Increased concentration of urate in the cerebrospinal fluid.		hp.json	Elevated CSF urate concentration|Increased cerebrospinal fluid urate	http://purl.obolibrary.org/obo/HP_0410199		
HP:0410198	biolink:PhenotypicFeature	Decreased uridine diphosphate glucose-4-epimerase level in red blood cells	A decrease in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.		hp.json	Decreased UDP-glucose 4-epimerase level in red blood cells|Decreased UDP-glucose 4-epimerase level in RBCs	http://purl.obolibrary.org/obo/HP_0410198		
GO:0051145	biolink:BiologicalProcess	smooth muscle cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary.		hp.json	nonstriated muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0051145		
HP:0410197	biolink:PhenotypicFeature	Increased uridine diphosphate glucose-4-epimerase level in red blood cells	An increase in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.		hp.json	Increased UDP-glucose 4-epimerase level in RBCs|Increased UDP-glucose 4-epimerase level in red blood cells	http://purl.obolibrary.org/obo/HP_0410197		
HP:0410196	biolink:PhenotypicFeature	Abnormal uridine diphosphate glucose-4-epimerase level in red blood cells	An abnormality in uridine diphosphate glucose-4-epimerase level in red blood cells. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose.		hp.json	Abnormal UDP-glucose 4-epimerase level in RBCs|Abnormal UDP-glucose 4-epimerase level in red blood cells	http://purl.obolibrary.org/obo/HP_0410196		
HP:0001929	biolink:PhenotypicFeature	Reduced factor XI activity	Decreased activity of coagulation factor XI. Factor XI, also known as plasma thromboplastin antecedent, is a serine proteinase that activates factor IX.	UMLS:C0015523|MSH:D005173|SNOMEDCT_US:49762007	hp.json	Low factor XI activity|Factor XI deficiency	http://purl.obolibrary.org/obo/HP_0001929		
GO:0110058	biolink:BiologicalProcess	positive regulation of blood vessel endothelial cell differentiation	Any process that activates or increases the frequency, rate or extent of blood vessel endothelial cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0110058		
GO:0110059	biolink:BiologicalProcess	negative regulation of blood vessel endothelial cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel endothelial cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0110059		
GO:0110057	biolink:BiologicalProcess	regulation of blood vessel endothelial cell differentiation	Any process that modulates the frequency, rate or extent of blood vessel endothelial cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0110057		
HP:0001923	biolink:PhenotypicFeature	Reticulocytosis	An elevation in the number of reticulocytes (immature erythrocytes) in the peripheral blood circulation.	SNOMEDCT_US:46049004|UMLS:C0206160|MSH:D045262	hp.json	Polychromasia|Increased number of immature red blood cells|Increased reticulocytes|Increased reticulocyte count|Increased immature red blood cells	http://purl.obolibrary.org/obo/HP_0001923		
HP:0001924	biolink:PhenotypicFeature	Sideroblastic anemia	Sideroblastic anemia results from a defect in the incorporation of iron into the heme molecule. A sideroblast is an erythroblast that has stainable deposits of iron in cytoplasm (this can be demonstrated by Prussian blue staining).	MSH:D000756|SNOMEDCT_US:41841004|UMLS:C0002896	hp.json	Hypersideremic anaemia|Sideroblastic anaemia|Hypersideremic anemia	http://purl.obolibrary.org/obo/HP_0001924		
HP:0001922	biolink:PhenotypicFeature	Vacuolated lymphocytes	The presence of clear, sharply defined vacuoles in the lymphocyte cytoplasm.	UMLS:C1836855	hp.json	Enlarged lysosomal vacuoles in lymphocytes|Vacuolated blood lymphocytes	http://purl.obolibrary.org/obo/HP_0001922		
HP:0001927	biolink:PhenotypicFeature	Acanthocytosis	Acanthocytosis is a type of poikilocytosis characterized by the presence of spikes on the cell surface. The cells have an irregular shape resembling many-pointed stars.	SNOMEDCT_US:250249008|UMLS:C0687751	hp.json	Acanthocytes|Red cell acanthocytosis	http://purl.obolibrary.org/obo/HP_0001927		hposlim_core
HP:0001928	biolink:PhenotypicFeature	Abnormality of coagulation	An abnormality of the process of blood coagulation. That is, altered ability or inability of the blood to clot.	SNOMEDCT_US:362970003|MSH:D006474|UMLS:C1846821|SNOMEDCT_US:64779008|MSH:D001778|UMLS:C0019087|UMLS:C0005779	hp.json	Abnormal blood coagulation studies|Blood coagulation disorder|Coagulation abnormality|Coagulation abnormalities|Haemorrhagic disorders	http://purl.obolibrary.org/obo/HP_0001928		
HP:0001920	biolink:PhenotypicFeature	Renal artery stenosis	The presence of stenosis of the renal artery.	UMLS:C0035067|SNOMEDCT_US:302233006|SNOMEDCT_US:282664001|MSH:D012078|Fyler:2634	hp.json	Narrowing of kidney artery	http://purl.obolibrary.org/obo/HP_0001920		
GO:0051151	biolink:BiologicalProcess	negative regulation of smooth muscle cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation.		hp.json	downregulation of smooth muscle cell differentiation|down regulation of smooth muscle cell differentiation|inhibition of smooth muscle cell differentiation|down-regulation of smooth muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0051151		
GO:0051152	biolink:BiologicalProcess	positive regulation of smooth muscle cell differentiation	Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation.		hp.json	up regulation of smooth muscle cell differentiation|stimulation of smooth muscle cell differentiation|up-regulation of smooth muscle cell differentiation|activation of smooth muscle cell differentiation|upregulation of smooth muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0051152		
GO:0051150	biolink:BiologicalProcess	regulation of smooth muscle cell differentiation	Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0051150		
GO:0051155	biolink:BiologicalProcess	positive regulation of striated muscle cell differentiation	Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.		hp.json	upregulation of striated muscle cell differentiation|up regulation of striated muscle cell differentiation|stimulation of striated muscle cell differentiation|up-regulation of striated muscle cell differentiation|activation of striated muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0051155		
GO:0051153	biolink:BiologicalProcess	regulation of striated muscle cell differentiation	Any process that modulates the frequency, rate or extent of striated muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0051153		
GO:0051154	biolink:BiologicalProcess	negative regulation of striated muscle cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation.		hp.json	inhibition of striated muscle cell differentiation|down-regulation of striated muscle cell differentiation|downregulation of striated muscle cell differentiation|down regulation of striated muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0051154		
GO:0051169	biolink:BiologicalProcess	nuclear transport	The directed movement of substances into, out of, or within the nucleus.	Wikipedia:Nuclear_transport	hp.json	nucleus transport	http://purl.obolibrary.org/obo/GO_0051169		goslim_yeast
HP:0001934	biolink:PhenotypicFeature	Persistent bleeding after trauma		UMLS:C1844374	hp.json	Excessive bleeding after minor trauma|Frequent bleeding with trauma|Prolonged bleeding after minor trauma	http://purl.obolibrary.org/obo/HP_0001934		
HP:0001935	biolink:PhenotypicFeature	Microcytic anemia	A kind of anemia in which the volume of the red blood cells is reduced.	UMLS:C0085576|SNOMEDCT_US:234349007|MSH:C562385	hp.json	Microcytic anaemia	http://purl.obolibrary.org/obo/HP_0001935		
HP:0001933	biolink:PhenotypicFeature	Subcutaneous hemorrhage	This term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses).	UMLS:C0854107	hp.json	Subcutaneous haemorrhage|Bleeding below the skin	http://purl.obolibrary.org/obo/HP_0001933		
HP:0001939	biolink:PhenotypicFeature	Abnormality of metabolism/homeostasis		UMLS:C4021768	hp.json	Metabolism abnormality|Laboratory abnormality	http://purl.obolibrary.org/obo/HP_0001939		
HP:0001937	biolink:PhenotypicFeature	Microangiopathic hemolytic anemia		SNOMEDCT_US:51071000|UMLS:C0221021|MSH:D000743	hp.json	Microangiopathic hemolytic anaemia	http://purl.obolibrary.org/obo/HP_0001937		
HP:0001930	biolink:PhenotypicFeature	Nonspherocytic hemolytic anemia		UMLS:C4025735	hp.json	Nonspherocytic hemolytic anaemia	http://purl.obolibrary.org/obo/HP_0001930		
HP:0001931	biolink:PhenotypicFeature	Hypochromic anemia	A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes.	MSH:D000747|UMLS:C0002884|SNOMEDCT_US:44452003	hp.json	Hypochromic anaemia	http://purl.obolibrary.org/obo/HP_0001931		
UBERON:0035927	biolink:AnatomicalEntity	sulcus of parietal lobe		HBA:9370	hp.json	parietal lobe sulci|parietal lobe sulcus|PLs	http://purl.obolibrary.org/obo/UBERON_0035927		
CHEBI:16765	biolink:ChemicalSubstance	tryptamine	An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position.	PMID:16126914|Reaxys:125513|PMID:24345948|KNApSAcK:C00001434|Gmelin:603448|CAS:61-54-1|PMID:24558969|DrugBank:DB08653|CAS:61-54-1|KEGG:C00398|PMID:22770225|CAS:61-54-1|PDBeChem:TSS|HMDB:HMDB0000303|Wikipedia:Tryptamine|Beilstein:125513|MetaCyc:TRYPTAMINE	hp.json	2-(1H-indol-3-yl)ethanamine|3-(2-Aminoethyl)indole|Tryptamine|1H-indole-3-ethanamine|2-(3-indolyl)ethylamine|2-(1H-INDOL-3-YL)ETHANAMINE	http://purl.obolibrary.org/obo/CHEBI_16765		3_STAR
HP:0001909	biolink:PhenotypicFeature	Leukemia	A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.	SNOMEDCT_US:269475001|UMLS:C0376545|MSH:D019337|SNOMEDCT_US:93143009|SNOMEDCT_US:87163000|SNOMEDCT_US:129154003|MSH:D007938|UMLS:C0023418	hp.json	Blood cancer|Leukaemia	http://purl.obolibrary.org/obo/HP_0001909		
PATO:0040043	biolink:NamedThing	increased proportionality to	A proportionality quality inhering in a bearer by virtue of the bearer's increased magnitude in respect to a related entity.		hp.json	increased ratio|increased proportionality|increased quotient|increased proportion	http://purl.obolibrary.org/obo/PATO_0040043		relational_slim
GO:0051179	biolink:BiologicalProcess	localization	Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation.		hp.json	single-organism localization|localisation|single organism localization|establishment and maintenance of cellular component location|establishment and maintenance of substance location|establishment and maintenance of substrate location|establishment and maintenance of localization|establishment and maintenance of position	http://purl.obolibrary.org/obo/GO_0051179		goslim_pir
HP:0001907	biolink:PhenotypicFeature	Thromboembolism	The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site.	SNOMEDCT_US:371039008|UMLS:C0085307|MSH:D013923|SNOMEDCT_US:13713005|UMLS:C0040038|MSH:D016769	hp.json	Embolism and thrombosis|Thromboembolic disease|Blood clot in blood vessel|Thromboembolic events	http://purl.obolibrary.org/obo/HP_0001907		
HP:0001908	biolink:PhenotypicFeature	Hypoplastic anemia	Anemia with varying degrees of erythrocytic hypoplasia without leukopenia or thrombocytopenia.	SNOMEDCT_US:167923006|MSH:D000741|SNOMEDCT_US:41614006|UMLS:C0178416	hp.json	Hypoplastic anaemia	http://purl.obolibrary.org/obo/HP_0001908		
GO:0110079	biolink:BiologicalProcess	regulation of placenta blood vessel development	Any process that modulates the frequency, rate or extent of placenta blood vessel development.		hp.json		http://purl.obolibrary.org/obo/GO_0110079		
PATO:0040047	biolink:NamedThing	fragmented	Existing or functioning as though broken into separate parts; disorganized; disunified.		hp.json		http://purl.obolibrary.org/obo/PATO_0040047		
GO:0110077	biolink:BiologicalProcess	vesicle-mediated intercellular transport	A cellular transport process in which transported substances are moved in extracellular vesicles between cells; transported substances are enclosed in the vesicle lumen or located in the extracellular vesicle membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0110077		
PATO:0040048	biolink:NamedThing	erythematous	Red due to increase blood circulation in a defined area.		hp.json	erythema|skin redness	http://purl.obolibrary.org/obo/PATO_0040048		
HP:0001901	biolink:PhenotypicFeature	Polycythemia	Polycythemia is diagnosed if the red blood cell count, the hemoglobin level, and the red blood cell volume all exceed the upper limits of normal.	MSH:D011086|UMLS:C0032461|UMLS:C1527405|SNOMEDCT_US:127062003|SNOMEDCT_US:109992005	hp.json	Abnormally shaped erythrocytes|Increased red blood cells|Polyglobulia|Erythrocytosis	http://purl.obolibrary.org/obo/HP_0001901		
HP:0001902	biolink:PhenotypicFeature	Giant platelets	Giant platelets are larger than 7 micrometers and usually 10 to 20 micrometers. The term giant platelet is used when the platelet is larger than the size of the average red cell in the field. (Description adapted from College of American Pathologists, Hematology Manual, 1998).	UMLS:C0333864|SNOMEDCT_US:44687006	hp.json		http://purl.obolibrary.org/obo/HP_0001902		
HP:0001900	biolink:PhenotypicFeature	Increased hemoglobin		UMLS:C0549448|SNOMEDCT_US:131141003	hp.json	Increased Hb|Increased haemoglobin	http://purl.obolibrary.org/obo/HP_0001900		
HP:0001905	biolink:PhenotypicFeature	Congenital thrombocytopenia	Thrombocytopenia with congenital onset.	UMLS:C0272278	hp.json	thrombocytopenia, congenital	http://purl.obolibrary.org/obo/HP_0001905		
HP:0001903	biolink:PhenotypicFeature	Anemia	A reduction in erythrocytes volume or hemoglobin concentration.	SNOMEDCT_US:271737000|UMLS:C0002871|UMLS:C0162119|SNOMEDCT_US:165397008|MSH:D000740	hp.json	Decreased haemoglobin|Anaemia|Low number of red blood cells or hemoglobin|Decreased hemoglobin|Low number of red blood cells or haemoglobin	http://purl.obolibrary.org/obo/HP_0001903		
HP:0001904	biolink:PhenotypicFeature	Neutropenia in presence of anti-neutropil antibodies	A type of neutropenia that is observed in the presence of granulocyte-specific antibodies.	UMLS:C0340971|SNOMEDCT_US:234425008	hp.json	Autoimmune neutropenia	http://purl.obolibrary.org/obo/HP_0001904		
GO:0051173	biolink:BiologicalProcess	positive regulation of nitrogen compound metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.		hp.json	upregulation of nitrogen metabolic process|up regulation of nitrogen metabolic process|positive regulation of nitrogen metabolism|stimulation of nitrogen metabolic process|up-regulation of nitrogen metabolic process|activation of nitrogen metabolic process|positive regulation of nitrogen metabolic process	http://purl.obolibrary.org/obo/GO_0051173		
GO:0051174	biolink:BiologicalProcess	regulation of phosphorus metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.		hp.json	regulation of phosphorus metabolism	http://purl.obolibrary.org/obo/GO_0051174		
GO:0051171	biolink:BiologicalProcess	regulation of nitrogen compound metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.		hp.json	regulation of nitrogen metabolic process|regulation of nitrogen metabolism	http://purl.obolibrary.org/obo/GO_0051171		
GO:0051172	biolink:BiologicalProcess	negative regulation of nitrogen compound metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.		hp.json	downregulation of nitrogen metabolic process|negative regulation of nitrogen metabolism|negative regulation of nitrogen metabolic process|down regulation of nitrogen metabolic process|inhibition of nitrogen metabolic process|down-regulation of nitrogen metabolic process	http://purl.obolibrary.org/obo/GO_0051172		
GO:0090741	biolink:CellularComponent	pigment granule membrane	Any membrane that is part of a pigment granule.		hp.json		http://purl.obolibrary.org/obo/GO_0090741		
PATO:0040041	biolink:NamedThing	avulsion fractured	A fractured quality in which the fragment of bone tears away from the main mass of bone as a result of physical trauma.		hp.json	fractured, avulsion	http://purl.obolibrary.org/obo/PATO_0040041		
PATO:0040042	biolink:NamedThing	decreased proportionality to	A proportionality quality inhering in a bearer by virtue of the bearer's decreased magnitude in respect to a related entity.		hp.json	decreased quotient|decreased proportion|decreased ratio|decreased proportionality	http://purl.obolibrary.org/obo/PATO_0040042		relational_slim
GO:0051175	biolink:BiologicalProcess	negative regulation of sulfur metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur.		hp.json	inhibition of sulfur metabolic process|down-regulation of sulfur metabolic process|negative regulation of sulphur metabolism|negative regulation of sulphur metabolic process|negative regulation of sulfur metabolism|downregulation of sulfur metabolic process|down regulation of sulfur metabolic process	http://purl.obolibrary.org/obo/GO_0051175		
UBERON:0008367	biolink:AnatomicalEntity	breast epithelium	An epithelium that is part of a breast.	BTO:0001428	hp.json		http://purl.obolibrary.org/obo/UBERON_0008367		
GO:0051176	biolink:BiologicalProcess	positive regulation of sulfur metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur.		hp.json	upregulation of sulfur metabolic process|positive regulation of sulphur metabolic process|positive regulation of sulfur metabolism|positive regulation of sulphur metabolism|up regulation of sulfur metabolic process|stimulation of sulfur metabolic process|up-regulation of sulfur metabolic process|activation of sulfur metabolic process	http://purl.obolibrary.org/obo/GO_0051176		
PATO:0040040	biolink:NamedThing	compression-fractured	A fractured quality that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.		hp.json	compression fractured|wedge fractured|fractured, compression|fractured, wedge	http://purl.obolibrary.org/obo/PATO_0040040		
HP:0001919	biolink:PhenotypicFeature	Acute kidney injury	Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia).	SNOMEDCT_US:14350001000004108|MSH:D058186|UMLS:C0022660|UMLS:C2609414|SNOMEDCT_US:14669001	hp.json	Acute kidney failure|Acute renal failure	http://purl.obolibrary.org/obo/HP_0001919		
HP:0001912	biolink:PhenotypicFeature	Abnormal basophil morphology	Any structural abnormality or abnormal count of basophils.	UMLS:C4025736	hp.json	Abnormality of basophils	http://purl.obolibrary.org/obo/HP_0001912		
HP:0001913	biolink:PhenotypicFeature	Granulocytopenia	An abnormally reduced number of granulocytes in the blood.	MSH:D000380|SNOMEDCT_US:417672002|SNOMEDCT_US:17182001|UMLS:C0001824	hp.json		http://purl.obolibrary.org/obo/HP_0001913		
HP:0001911	biolink:PhenotypicFeature	Abnormal granulocyte morphology	Any structural abnormality or abnormal count of granulocytes.	UMLS:C0427515|SNOMEDCT_US:250274006	hp.json	Abnormality of granulocytes	http://purl.obolibrary.org/obo/HP_0001911		
GO:0110081	biolink:BiologicalProcess	negative regulation of placenta blood vessel development	Any process that stops, prevents or reduces the frequency, rate or extent of placenta blood vessel development.		hp.json		http://purl.obolibrary.org/obo/GO_0110081		
GO:2000977	biolink:BiologicalProcess	regulation of forebrain neuron differentiation	Any process that modulates the frequency, rate or extent of forebrain neuron differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2000977		
HP:0001917	biolink:PhenotypicFeature	Renal amyloidosis	A form of amyloidosis that affects the kidney. On hematoxylin and eosin stain, amyloid is identified as extracellular amorphous material that is lightly eosinophilic. These deposits often stain weakly for periodic acid Schiff (PAS), demonstrate a blue-to-gray hue on the trichrome stain and are typically negative on the Jones methenamine silver (JMS) stain. These tinctorial properties contrast with the histologic appearance of collagen, a major component of basement membranes, mesangial matrix and areas of sclerosis, which demonstrates strong positivity for PAS and JMS (See Figure 1 of PMID:25852856).	SNOMEDCT_US:48713002|UMLS:C0268382	hp.json		http://purl.obolibrary.org/obo/HP_0001917		
GO:2000978	biolink:BiologicalProcess	negative regulation of forebrain neuron differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2000978		
GO:2000979	biolink:BiologicalProcess	positive regulation of forebrain neuron differentiation	Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2000979		
HP:0001915	biolink:PhenotypicFeature	Aplastic anemia	Aplastic anemia is defined as pancytopenia with a hypocellular marrow.	UMLS:C0002874|SNOMEDCT_US:304132006|SNOMEDCT_US:306058006|MSH:D000741	hp.json	Aplastic anaemia	http://purl.obolibrary.org/obo/HP_0001915		
GO:0110080	biolink:BiologicalProcess	positive regulation of placenta blood vessel development	Any process that activates or increases the frequency, rate or extent of placenta blood vessel development.		hp.json		http://purl.obolibrary.org/obo/GO_0110080		
UBERON:0011997	biolink:AnatomicalEntity	coelom	The aggregate of the coelemic cavity lumen plus the membranes that line the lumen.	EHDAA2:0004731|Wikipedia:Coelom	hp.json	coelomic cavity|schizocoelom|enterocoelom|coelem|haemocoelom	http://purl.obolibrary.org/obo/UBERON_0011997		
CHEBI:16782	biolink:ChemicalSubstance	(S)-2-hydroxyglutarate(2-)	A 2-hydroxyglutarate(2-) that has (2S)-configuration.	Reaxys:5257108|Beilstein:5257108|KEGG:C03196|MetaCyc:CPD-381	hp.json	(S)-2-hydroxyglutarate|(2S)-2-hydroxypentanedioate	http://purl.obolibrary.org/obo/CHEBI_16782		3_STAR
GO:0016746	biolink:MolecularActivity	acyltransferase activity	Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).	Reactome:R-HSA-6792572|Reactome:R-HSA-8858298|Reactome:R-HSA-193491|Reactome:R-HSA-192312|Reactome:R-HSA-159431|EC:2.3.-.-	hp.json	transferase activity, transferring acyl groups	http://purl.obolibrary.org/obo/GO_0016746		goslim_drosophila|goslim_chembl
GO:0016747	biolink:MolecularActivity	acyltransferase activity, transferring groups other than amino-acyl groups	Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).	EC:2.3.1.-	hp.json	transferase activity, transferring groups other than amino-acyl groups|transferase activity, transferring acyl groups other than amino-acyl groups	http://purl.obolibrary.org/obo/GO_0016747		
CHEBI:51060	biolink:ChemicalSubstance	hormone agonist	A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.		hp.json		http://purl.obolibrary.org/obo/CHEBI_51060		3_STAR
CHEBI:51061	biolink:ChemicalSubstance	hormone receptor modulator	A drug that modulates the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.		hp.json	hormone receptor modulators	http://purl.obolibrary.org/obo/CHEBI_51061		3_STAR
MPATH:0	biolink:NamedThing	pathological entity	Pathological structure or process		hp.json		http://purl.obolibrary.org/obo/MPATH_0		
GO:0016740	biolink:MolecularActivity	transferase activity	Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.	Reactome:R-HSA-8868783|EC:2.-.-.-|Reactome:R-HSA-5668414|Reactome:R-HSA-1483089|Reactome:R-HSA-1483186	hp.json		http://purl.obolibrary.org/obo/GO_0016740		goslim_pir|goslim_drosophila|goslim_chembl|goslim_aspergillus|goslim_metagenomics|goslim_mouse|goslim_yeast|goslim_generic|goslim_candida|prokaryote_subset|goslim_plant
MPATH:1	biolink:NamedThing	cell and tissue damage	The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors.		hp.json		http://purl.obolibrary.org/obo/MPATH_1		
PATO:0040034	biolink:NamedThing	fractured	A broken quality where an entity is cracked or broken, usually a bone.		hp.json		http://purl.obolibrary.org/obo/PATO_0040034		
PATO:0040030	biolink:NamedThing	decreased width and length	A width and length quality which is relatively small, where both width and length are decreased.		hp.json		http://purl.obolibrary.org/obo/PATO_0040030		value_slim
CHEBI:63070	biolink:ChemicalSubstance	beta-alaninate	A beta-amino-acid anion that is the conjugate base of beta-alanine.	Reaxys:3536336	hp.json	beta-alaninate(1-)|3-aminopropanoate|beta-alaninate anion	http://purl.obolibrary.org/obo/CHEBI_63070		3_STAR
PATO:0040019	biolink:NamedThing	fibrotic	Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process.		hp.json		http://purl.obolibrary.org/obo/PATO_0040019		
CHEBI:38077	biolink:ChemicalSubstance	polypyrrole	A compound composed of two or more pyrrole units.	Beilstein:8538310	hp.json	poly(pyrrole)s|PPys|polypyrroles	http://purl.obolibrary.org/obo/CHEBI_38077		3_STAR
UBERON:0008425	biolink:AnatomicalEntity	mammary ridge	A ridge of epidermal cells that will form the mammary placodes.	EMAPA:18541	hp.json	mammary line|mammary gland ridge|mammary fold|milk line	http://purl.obolibrary.org/obo/UBERON_0008425		
UBERON:0008429	biolink:AnatomicalEntity	cervical vertebral foramen	A vertebral foramen that is part of a cervical vertebra.	FMA:13480	hp.json		http://purl.obolibrary.org/obo/UBERON_0008429		
UBERON:0008420	biolink:AnatomicalEntity	buccal epithelium	An epithelium that is part of a buccal mucosa.	BTO:0004803	hp.json		http://purl.obolibrary.org/obo/UBERON_0008420		
GO:0004736	biolink:MolecularActivity	pyruvate carboxylase activity	Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate.	Reactome:R-HSA-70501|EC:6.4.1.1|RHEA:20844|MetaCyc:PYRUVATE-CARBOXYLASE-RXN|KEGG_REACTION:R00344	hp.json	pyruvic carboxylase activity|pyruvate:carbon-dioxide ligase (ADP-forming)	http://purl.obolibrary.org/obo/GO_0004736		
CHEBI:26078	biolink:ChemicalSubstance	phosphoric acid	A phosphorus oxoacid that consists of one oxo and three hydroxy groups joined covalently to a central phosphorus atom.	Gmelin:2000|CAS:7664-38-2|CAS:7664-38-2|HMDB:HMDB0002142|PMID:11455380|PMID:17518491|Drug_Central:4478|PMID:15630224|Reaxys:1921286|Beilstein:1921286|PMID:17439666|PMID:22333268|KEGG:D05467|PMID:22401268|CAS:7664-38-2|Wikipedia:Phosphoric_Acid|PMID:22381614|PMID:22282755|KEGG:C00009|KNApSAcK:C00007408	hp.json	trihydroxidooxidophosphorus|Phosphorsaeureloesungen|trihydrogen tetraoxophosphate(3-)|[PO(OH)3]|orthophosphoric acid|Orthophosphoric acid|H3PO4|tetraoxophosphoric acid|Phosphorsaeure|Phosphoric acid|acide phosphorique|Phosphate|acidum phosphoricum|phosphoric acid	http://purl.obolibrary.org/obo/CHEBI_26078		3_STAR
CHEBI:26079	biolink:ChemicalSubstance	phosphoric acid derivative			hp.json		http://purl.obolibrary.org/obo/CHEBI_26079		1_STAR
CHEBI:26082	biolink:ChemicalSubstance	phosphorus molecular entity			hp.json	phosphorus molecular entities	http://purl.obolibrary.org/obo/CHEBI_26082		3_STAR
GO:1905503	biolink:BiologicalProcess	regulation of motile cilium assembly	Any process that modulates the frequency, rate or extent of motile cilium assembly.		hp.json	regulation of motile primary cilia formation|regulation of motile primary cilia assembly|regulation of nodal cilium formation|regulation of motile primary cilium assembly|regulation of motile primary cilium formation|regulation of nodal cilium assembly	http://purl.obolibrary.org/obo/GO_1905503		
GO:1905504	biolink:BiologicalProcess	negative regulation of motile cilium assembly	Any process that stops, prevents or reduces the frequency, rate or extent of motile cilium assembly.		hp.json	downregulation of nodal cilium assembly|downregulation of nodal cilium formation|down regulation of motile primary cilia formation|downregulation of motile primary cilium assembly|inhibition of motile primary cilium assembly|downregulation of motile primary cilia assembly|inhibition of nodal cilium assembly|down-regulation of motile primary cilia formation|down regulation of nodal cilium formation|negative regulation of motile primary cilia formation|down regulation of motile primary cilium assembly|negative regulation of nodal cilium formation|negative regulation of motile primary cilium formation|down-regulation of motile primary cilium formation|down-regulation of nodal cilium formation|negative regulation of nodal cilium assembly|down-regulation of motile primary cilium assembly|down-regulation of nodal cilium assembly|negative regulation of motile primary cilium assembly|inhibition of motile primary cilium formation|down regulation of motile primary cilium formation|inhibition of nodal cilium formation|negative regulation of motile primary cilia assembly|down regulation of nodal cilium assembly|down-regulation of motile primary cilia assembly|inhibition of motile primary cilia assembly|downregulation of motile primary cilia formation|inhibition of motile primary cilia formation|down regulation of motile primary cilia assembly|downregulation of motile primary cilium formation	http://purl.obolibrary.org/obo/GO_1905504		
GO:1905505	biolink:BiologicalProcess	positive regulation of motile cilium assembly	Any process that activates or increases the frequency, rate or extent of motile cilium assembly.		hp.json	activation of motile primary cilium formation|up-regulation of motile primary cilium formation|up regulation of motile primary cilium assembly|up-regulation of nodal cilium assembly|up-regulation of nodal cilium formation|up regulation of motile primary cilium formation|up-regulation of motile primary cilium assembly|up regulation of nodal cilium assembly|activation of motile primary cilia assembly|up-regulation of motile primary cilia assembly|positive regulation of motile primary cilium formation|positive regulation of nodal cilium assembly|upregulation of motile primary cilia formation|up regulation of motile primary cilia assembly|activation of nodal cilium formation|positive regulation of motile primary cilia assembly|upregulation of nodal cilium formation|upregulation of motile primary cilium formation|positive regulation of motile primary cilia formation|upregulation of motile primary cilium assembly|upregulation of nodal cilium assembly|activation of motile primary cilia formation|activation of nodal cilium assembly|up regulation of motile primary cilia formation|upregulation of motile primary cilia assembly|positive regulation of nodal cilium formation|up-regulation of motile primary cilia formation|activation of motile primary cilium assembly|positive regulation of motile primary cilium assembly|up regulation of nodal cilium formation	http://purl.obolibrary.org/obo/GO_1905505		
GO:1905516	biolink:BiologicalProcess	positive regulation of fertilization	Any process that activates or increases the frequency, rate or extent of fertilization.		hp.json	up-regulation of fertilization|up-regulation of syngamy|up regulation of fertilization|activation of fertilization|up regulation of syngamy|activation of syngamy|positive regulation of syngamy|upregulation of fertilization|upregulation of syngamy	http://purl.obolibrary.org/obo/GO_1905516		
GO:1905517	biolink:BiologicalProcess	macrophage migration	The orderly movement of a macrophage from one site to another.		hp.json		http://purl.obolibrary.org/obo/GO_1905517		
GO:0051100	biolink:BiologicalProcess	negative regulation of binding	Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.		hp.json	down-regulation of binding|down regulation of binding|inhibition of binding|downregulation of binding	http://purl.obolibrary.org/obo/GO_0051100		
HP:0011252	biolink:PhenotypicFeature	Cryptotia	Invagination of the superior part of the auricle under a fold of temporal skin.	UMLS:C2315717|SNOMEDCT_US:429967001	hp.json	Hidden ear|Buried ear	http://purl.obolibrary.org/obo/HP_0011252		hposlim_core
HP:0011253	biolink:PhenotypicFeature	Type I cryptotia	A type of cryptotia associated with reduction in size of the antihelix and superior crus.	UMLS:C4023442	hp.json	Type 1 cryptotia	http://purl.obolibrary.org/obo/HP_0011253		
HP:0011254	biolink:PhenotypicFeature	Type II cryptotia	A type of cryptotia associated with reduction in size of the antihelix and inferior crus that are affected.	UMLS:C4023441	hp.json	Type 2 cryptotia	http://purl.obolibrary.org/obo/HP_0011254		
HP:0011255	biolink:PhenotypicFeature	Absent crus of helix	Continuum between the tragus and ascending helix, without any evidence of a posterior extension (crus) towards the concha.	UMLS:C4021185	hp.json	Helix, crus, absent	http://purl.obolibrary.org/obo/HP_0011255		
HP:0011256	biolink:PhenotypicFeature	Crus of helix connected to antihelix	Extension of the ridge of the crus helix across the ear and connection of the crus to the antihelix.	UMLS:C4021184	hp.json	Helix, crus, connected to antihelix	http://purl.obolibrary.org/obo/HP_0011256		
HP:0011257	biolink:PhenotypicFeature	Serpiginous crus of helix	Curving course of the crus of the helix, approaching or joining the antitragus.	UMLS:C4021183	hp.json	Helix, crus, serpiginous	http://purl.obolibrary.org/obo/HP_0011257		
HP:0011258	biolink:PhenotypicFeature	Tragal bridge of crus of helix	The anterior origin of the crus encompasses the superior margin of the tragus, the crus overrides the upper portion of the conchal cavum and ends at the antihelix.	UMLS:C4021182	hp.json	Helix, crus, tragal bridge	http://purl.obolibrary.org/obo/HP_0011258		
GO:0099098	biolink:BiologicalProcess	microtubule polymerization based movement	The movement of a cellular component as a result of microtubule polymerization.		hp.json		http://purl.obolibrary.org/obo/GO_0099098		
HP:0011259	biolink:PhenotypicFeature	Expanded terminal portion of crus of helix	Widening, rather than tapering, of the crus at its posterior border near the antihelix.	UMLS:C4021181	hp.json	Helix, crus, expanded terminal portion	http://purl.obolibrary.org/obo/HP_0011259		
GO:0002185	biolink:CellularComponent	creatine kinase complex	A protein complex having creatine kinase activity.		hp.json		http://purl.obolibrary.org/obo/GO_0002185		
GO:0002187	biolink:CellularComponent	mitochondrial creatine kinase complex	An octomeric protein complex having creatine kinase activity.		hp.json		http://purl.obolibrary.org/obo/GO_0002187		
HP:0011250	biolink:PhenotypicFeature	Bifid antitragus	Double rather than single peak of the antitragus.	UMLS:C4021187	hp.json	Double antitragus	http://purl.obolibrary.org/obo/HP_0011250		
HP:0011251	biolink:PhenotypicFeature	Underdeveloped antitragus	Reduction in the anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix.	UMLS:C4021186	hp.json	Hypotrophic antitragus|Small antitragus|Hypoplastic antitragus	http://purl.obolibrary.org/obo/HP_0011251		
CHEBI:133291	biolink:ChemicalSubstance	saturated dicarboxylic acid dianion(2-)	A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid that contains no carbon-carbon double bonds.		hp.json	a saturated dicarboxylic acid|saturated dicarboxylate(2-)	http://purl.obolibrary.org/obo/CHEBI_133291		3_STAR
CHEBI:133294	biolink:ChemicalSubstance	oxo dicarboxylic acid dianion	A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of any oxo dicarboxylic acid.		hp.json	oxo dicarboxylic acid|oxo dicarboxylic acid dianions	http://purl.obolibrary.org/obo/CHEBI_133294		3_STAR
HP:0011241	biolink:PhenotypicFeature	Serpiginous stem of antihelix	Posterior curving of the antihelix from its origin at the antitragus, traveling initially almost perpendicular to the descending helix and obscuring some of the concha.	UMLS:C4021193	hp.json	Antihelix, stem, serpiginous	http://purl.obolibrary.org/obo/HP_0011241		
HP:0011242	biolink:PhenotypicFeature	Underdeveloped stem of antihelix	Decreased protrusion of the antihelical ridge, proximal to its bifurcation, relative to the prominence of a normal helix.	UMLS:C4021192	hp.json	Antihelix, stem, underdeveloped	http://purl.obolibrary.org/obo/HP_0011242		
HP:0011243	biolink:PhenotypicFeature	Abnormality of inferior crus of antihelix	An abnormality of the inferior crus of the antihelix is the lower cartilaginous ridge arising at the bifurcation of the antihelix that ends beneath the fold of the ascending helix, and separates the concha from the triangular fossa.	UMLS:C4021191	hp.json	Abnormality of anterior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011243		
HP:0011244	biolink:PhenotypicFeature	Abnormality of stem of antihelix	An abnormality of the stem of the antihelix, which is the part below the bifurcation of the antihelix into the inferior and superior crura.	UMLS:C4023445	hp.json		http://purl.obolibrary.org/obo/HP_0011244		
HP:0011245	biolink:PhenotypicFeature	Abnormality of superior crus of antihelix	An abnormality of the superior crus of the antihelix is the upper cartilaginous ridge arising at the bifurcation of the antihelix that ends beneath the fold of the ascending helix, and separates the concha from the triangular fossa.	UMLS:C4021190	hp.json	Abnormality of posterior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011245		
HP:0011246	biolink:PhenotypicFeature	Underdeveloped superior crus of antihelix	Decreased protrusion of the superior crus relative to the prominence of a normal antihelix stem.	UMLS:C4021189	hp.json	Hypoplastic superior crus of antihelix|Hypotrophic superior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011246		
HP:0011247	biolink:PhenotypicFeature	Prominent superior crus of antihelix	Increased protrusion of the superior crus relative to the prominence of a normal antihelix stem.	UMLS:C4021188	hp.json	Hyperplastic superior crus of antihelix|Hypertrophic superior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011247		
OBO:hp#plural_form	biolink:NamedThing	plural form			hp.json		http://purl.obolibrary.org/obo/hp#plural_form		
HP:0011248	biolink:PhenotypicFeature	Everted antitragus	Positioning of the antitragus at an angle perpendicular to the plane of the ear (oriented away from the plane of the ear).	UMLS:C4023444	hp.json		http://purl.obolibrary.org/obo/HP_0011248		
HP:0011240	biolink:PhenotypicFeature	Prominent stem of antihelix	Increased protrusion of the antihelical ridge, proximal to its bifurcation, relative to the prominence of the helix.	UMLS:C4020910	hp.json	Hyperplastic antihelix stem|Hypertrophic antihelix stem	http://purl.obolibrary.org/obo/HP_0011240		
HP:0011249	biolink:PhenotypicFeature	Absent antitragus	Absence of the anterosuperior prominence of the area between the bottom of the incisura and the inner margin of the antihelix.	UMLS:C4023443	hp.json		http://purl.obolibrary.org/obo/HP_0011249		
PATO:0015001	biolink:NamedThing	absence due to degeneration	Absence due to a degenerative process.		hp.json		http://purl.obolibrary.org/obo/PATO_0015001		value_slim|absent_slim
HP:0011230	biolink:PhenotypicFeature	Laterally extended eyebrow	An eyebrow that extends laterally beyond the orbital rim rather than turning gently downward at that location.	UMLS:C4023451	hp.json	Laterally extended eyebrows|Increased lateral length of eyebrow|Laterally elongated eyebrow	http://purl.obolibrary.org/obo/HP_0011230		
HP:0011231	biolink:PhenotypicFeature	Prominent eyelashes	Eyelashes that draw the attention of the viewer due to increased density and/or length and/or curl without meeting the criteria of trichomegaly.	UMLS:C4023450|UMLS:C1835802	hp.json	Prominent eyelashes|Thick eyelashes	http://purl.obolibrary.org/obo/HP_0011231		
HP:0011232	biolink:PhenotypicFeature	Infra-orbital fold	Elevated ridge(s) of skin starting well below the medial aspect of the lower lid that curves gradually upward toward and/or across the nasal bridge.	UMLS:C4023449	hp.json	Infraorbital fold|Dennie-Morgan fold	http://purl.obolibrary.org/obo/HP_0011232		hposlim_core
HP:0011233	biolink:PhenotypicFeature	Antihelical shelf	Antihelix protrusion directed more anteriorly than laterally, forming a shelf overlying the posterior concha.	UMLS:C4021197	hp.json	Conchal shelf	http://purl.obolibrary.org/obo/HP_0011233		
HP:0011234	biolink:PhenotypicFeature	Absent antihelix	No discernible ridge between concha and triangular fossa and helix.	UMLS:C4023448	hp.json		http://purl.obolibrary.org/obo/HP_0011234		
HP:0011235	biolink:PhenotypicFeature	Additional crus of antihelix	Supernumerary ridge or crus of the ear arising from the antihelix.	UMLS:C4023447	hp.json		http://purl.obolibrary.org/obo/HP_0011235		
PATO:0015006	biolink:NamedThing	polymeric	A quality inhering in a structure by virtue of it consisting of many of repeated, similar or identical subunits, arranged in some orderly array.		hp.json		http://purl.obolibrary.org/obo/PATO_0015006		value_slim
HP:0011236	biolink:PhenotypicFeature	Angulated antihelix	Antihelical ridge that forms an acute angle between the antitragus and its bifurcation (stem) instead of a gently curving arc.	UMLS:C4023446	hp.json		http://purl.obolibrary.org/obo/HP_0011236		
HP:0011237	biolink:PhenotypicFeature	Broad inferior crus of antihelix	Increased width of the inferred cross-section of the inferior crus.	UMLS:C4021196	hp.json	Antihelix, inferior crus, broad	http://purl.obolibrary.org/obo/HP_0011237		
HP:0011238	biolink:PhenotypicFeature	Prominent inferior crus of antihelix	Increased protrusion of the inferior crus relative to the prominence of the antihelix stem.	UMLS:C4021195	hp.json	Antihelix, inferior crus, prominent|Hyperplastic inferior crus of antihelix|Hypertrophic inferior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011238		
HP:0011239	biolink:PhenotypicFeature	Underdeveloped inferior crus of antihelix	Decreased protrusion of the inferior crus relative to the prominence of the antihelix stem.	UMLS:C4021194	hp.json	Antihelix, inferior crus, underdeveloped|Hypoplastic inferior crus of antihelix|Hypotrophic inferior crus of antihelix	http://purl.obolibrary.org/obo/HP_0011239		
PATO:0015007	biolink:NamedThing	prominence	A quality inhering in a bearer by virtue of the degree to which the bearers stands out or projects beyond a surface or line.		hp.json		http://purl.obolibrary.org/obo/PATO_0015007		attribute_slim
PATO:0015008	biolink:NamedThing	distensibility			hp.json		http://purl.obolibrary.org/obo/PATO_0015008		
HP:0011220	biolink:PhenotypicFeature	Prominent forehead	Forward prominence of the entire forehead, due to protrusion of the frontal bone.	UMLS:C1867446|UMLS:C1837260	hp.json	Prominence of frontal region|Prominent forehead|Protruding forehead|Bulging forehead|Pronounced forehead	http://purl.obolibrary.org/obo/HP_0011220		hposlim_core
HP:0011221	biolink:PhenotypicFeature	Vertical forehead creases	Vertical soft tissue creases in the midline of the forehead, often extending from the hairline to the brow, and seen with facial expression or when the face is at rest.	UMLS:C4023456	hp.json	Frontal creases of face|Vertical forehead creases|Vertical forehead wrinkles|Vertical forehead rhytids	http://purl.obolibrary.org/obo/HP_0011221		hposlim_core
HP:0011222	biolink:PhenotypicFeature	Depressed glabella	Posterior positioning of the glabella, i.e., of the midline forehead between the supraorbital ridges.	UMLS:C4023455	hp.json	Flat glabella|Flat area between the eyebrows|Deficiency of glabella|Concave glabella|Hypoplasia of glabella|Deficient area between the eyebrows	http://purl.obolibrary.org/obo/HP_0011222		
HP:0011223	biolink:PhenotypicFeature	Metopic depression	Linear vertical groove in the midline of the forehead, extending from hairline to glabella.	UMLS:C4023454	hp.json	Depression of frontal cranial suture|Depression of metopic cranial suture|Frontal suture depression	http://purl.obolibrary.org/obo/HP_0011223		hposlim_core
HP:0011224	biolink:PhenotypicFeature	Ablepharon	Absent eyelids.	UMLS:C0266574|UMLS:C4020757|SNOMEDCT_US:13401001|SNOMEDCT_US:708541009	hp.json	Aplasia of the eyelids|Agenesis of eyelids|Ablepharon of eyelid|Absent eyelids|Missing eyelids	http://purl.obolibrary.org/obo/HP_0011224		hposlim_core
HP:0011225	biolink:PhenotypicFeature	Epiblepharon	Redundant eyelid skin pressing the eyelashes against the cornea and/or conjunctiva.	SNOMEDCT_US:253212001|UMLS:C0344503	hp.json		http://purl.obolibrary.org/obo/HP_0011225		hposlim_core
HP:0011226	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the eyelid	Absence or underdevelopment of the eyelid.	UMLS:C4023453	hp.json	Failure of development of eyelid|Hypotrophic eyelid	http://purl.obolibrary.org/obo/HP_0011226		
GO:0099083	biolink:BiologicalProcess	retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission	Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide.		hp.json		http://purl.obolibrary.org/obo/GO_0099083		goslim_synapse
GO:0099081	biolink:CellularComponent	supramolecular polymer	A polymeric supramolecular structure.		hp.json		http://purl.obolibrary.org/obo/GO_0099081		
GO:0099082	biolink:BiologicalProcess	retrograde trans-synaptic signaling by neuropeptide	Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide.		hp.json		http://purl.obolibrary.org/obo/GO_0099082		goslim_synapse
GO:0099080	biolink:CellularComponent	supramolecular complex	A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber.		hp.json		http://purl.obolibrary.org/obo/GO_0099080		
HP:0011227	biolink:PhenotypicFeature	Elevated circulating C-reactive protein concentration	An abnormal elevation of the C-reactive protein level in the blood circulation.	UMLS:C0742906|UMLS:C4023452	hp.json	Elevated CRP|Elevated C-reactive protein level	http://purl.obolibrary.org/obo/HP_0011227		
HP:0011228	biolink:PhenotypicFeature	Horizontal eyebrow	An eyebrow that extends straight across the brow, without curve.	UMLS:C3277019	hp.json	Straight eyebrow|Flat eyebrow|Horizontal eyebrow|Lack of eyebrow arch|Lack of eyebrow curvature|Straight eyebrows	http://purl.obolibrary.org/obo/HP_0011228		hposlim_core
HP:0011229	biolink:PhenotypicFeature	Broad eyebrow	Regional increase in the width (height) of the eyebrow.	UMLS:C1856121	hp.json	Broad eyebrows|Increased vertical width of eyebrow|Flared eyebrow|Increased vertical height of eyebrow|Broad eyebrow|Flared eyebrows|Increased vertical thickness of eyebrow	http://purl.obolibrary.org/obo/HP_0011229		hposlim_core
HP:0011296	biolink:PhenotypicFeature	EEG with temporal sharp waves	EEG with sharp waves in the temporal region, i.e., sharp transient waves of a duration between 80 and 200 msec.	UMLS:C2206519	hp.json		http://purl.obolibrary.org/obo/HP_0011296		
HP:0011297	biolink:PhenotypicFeature	Abnormal digit morphology	A morphological abnormality of a digit, i.e., of a finger or toe.	UMLS:C3550704	hp.json	Abnormality of digit|Digital anomalies|Abnormality of fingers or toes	http://purl.obolibrary.org/obo/HP_0011297		hposlim_core
HP:0011298	biolink:PhenotypicFeature	Prominent digit pad	A soft tissue prominence of the ventral aspects of the fingertips or toe tips.	UMLS:C4023424	hp.json	Prominent digit pad	http://purl.obolibrary.org/obo/HP_0011298		
HP:0011299	biolink:PhenotypicFeature	Partial absence of finger	The absence of a phalangeal segment of a finger.	UMLS:C4023423	hp.json	Partial absence of finger	http://purl.obolibrary.org/obo/HP_0011299		hposlim_core
HP:0011290	biolink:PhenotypicFeature	EEG with frontal sharp slow waves	EEG with sharp slow waves in the frontal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.	UMLS:C4023426	hp.json		http://purl.obolibrary.org/obo/HP_0011290		
HP:0011291	biolink:PhenotypicFeature	EEG with central sharp slow waves	EEG with sharp slow waves in the central region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.	UMLS:C4023425	hp.json		http://purl.obolibrary.org/obo/HP_0011291		
HP:0011292	biolink:PhenotypicFeature	EEG with occipital sharp waves	EEG with sharp waves in the occipital region, i.e., sharp transient waves of a duration between 80 and 200 msec.	UMLS:C2206521	hp.json		http://purl.obolibrary.org/obo/HP_0011292		
HP:0011293	biolink:PhenotypicFeature	EEG with central sharp waves	EEG with sharp waves in the central region, i.e., sharp transient waves of a duration between 80 and 200 msec.	UMLS:C2207327	hp.json		http://purl.obolibrary.org/obo/HP_0011293		
HP:0011294	biolink:PhenotypicFeature	EEG with frontal sharp waves	EEG with sharp waves in the frontal region, i.e., sharp transient waves of a duration between 80 and 200 msec.	UMLS:C2206518	hp.json		http://purl.obolibrary.org/obo/HP_0011294		
HP:0011295	biolink:PhenotypicFeature	EEG with parietal sharp waves	EEG with sharp waves in the parietal region, i.e., sharp transient waves of a duration between 80 and 200 msec.	UMLS:C2206520	hp.json		http://purl.obolibrary.org/obo/HP_0011295		
GO:0016787	biolink:MolecularActivity	hydrolase activity	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.	Reactome:R-HSA-1236938|Reactome:R-HSA-8938314|Reactome:R-HSA-6786190|Reactome:R-HSA-2029475|Reactome:R-HSA-6788295|Reactome:R-HSA-5695964|EC:3.-.-.-|Reactome:R-HSA-5694583|Reactome:R-HSA-8952137	hp.json		http://purl.obolibrary.org/obo/GO_0016787		goslim_mouse|goslim_candida|goslim_yeast|goslim_generic|prokaryote_subset|goslim_plant|goslim_pir|goslim_drosophila|goslim_chembl|goslim_metagenomics
GO:0016788	biolink:MolecularActivity	hydrolase activity, acting on ester bonds	Catalysis of the hydrolysis of any ester bond.	Reactome:R-HSA-9023617|Reactome:R-HSA-9023619|EC:3.1.-.-|Reactome:R-HSA-162729	hp.json	esterase activity	http://purl.obolibrary.org/obo/GO_0016788		goslim_chembl
CHEBI:133251	biolink:ChemicalSubstance	3-hydroxydicarboxylate(2-)	A dicarboxylic acid dianion that results from the removal of a proton from both of the carboxylic acid groups of any 3-hydroxydicarboxylic acid.		hp.json	a 3-hydroxy dicarboxylic acid|3-hydroxydicarboxylic acid dianion(2-)	http://purl.obolibrary.org/obo/CHEBI_133251		3_STAR
HP:0011285	biolink:PhenotypicFeature	Long-segment aganglionic megacolon	A type of aganglionic megacolon in which the aganglionic segment extends proximal to the sigmoid.	UMLS:C4023430	hp.json		http://purl.obolibrary.org/obo/HP_0011285		
HP:0011286	biolink:PhenotypicFeature	Total colonic aganglionosis	A type of aganglionic megacolon in which the aganglionic segment comprises the entire colon.	SNOMEDCT_US:253780003|SNOMEDCT_US:360441005|UMLS:C0085758|MSH:D006627	hp.json		http://purl.obolibrary.org/obo/HP_0011286		
HP:0011287	biolink:PhenotypicFeature	EEG with occipital sharp slow waves	EEG with sharp slow waves in the occipital region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.	UMLS:C4023429	hp.json		http://purl.obolibrary.org/obo/HP_0011287		
HP:0011288	biolink:PhenotypicFeature	EEG with parietal sharp slow waves	EEG with sharp slow waves in the parietal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.	UMLS:C4023428	hp.json		http://purl.obolibrary.org/obo/HP_0011288		
HP:0011289	biolink:PhenotypicFeature	EEG with temporal sharp slow waves	EEG with sharp slow waves in the temporal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.	UMLS:C4023427	hp.json		http://purl.obolibrary.org/obo/HP_0011289		
GO:0002158	biolink:BiologicalProcess	osteoclast proliferation	The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.		hp.json		http://purl.obolibrary.org/obo/GO_0002158		
HP:0011280	biolink:PhenotypicFeature	Abnormality of urine calcium concentration	An abnormality of calcium concentration in the urine.	UMLS:C4023434	hp.json	Abnormality of urine Ca2+ concentration|Abnormality of urine Ca concentration	http://purl.obolibrary.org/obo/HP_0011280		
HP:0011281	biolink:PhenotypicFeature	Abnormality of urine catecholamine level	An abnormal amount of urinary catecholamine concentration.	UMLS:C4023433|MP:0011478	hp.json		http://purl.obolibrary.org/obo/HP_0011281		
HP:0011282	biolink:PhenotypicFeature	Abnormal hindbrain morphology	An abnormality of the hindbrain, also known as the rhombencephalon.	UMLS:C4021170	hp.json	Abnormality of hindbrain morphology|Abnormal shape of hindbrain|Abnormality of the hindbrain	http://purl.obolibrary.org/obo/HP_0011282		
HP:0011283	biolink:PhenotypicFeature	Abnormal metencephalon morphology	An abnormality of the metencephalon. The metencephalon is the part of the hindbrain that consists of the pons and the cerebellum.	UMLS:C4023432	hp.json	Abnormality of the metencephalon	http://purl.obolibrary.org/obo/HP_0011283		
HP:0011284	biolink:PhenotypicFeature	Short-segment aganglionic megacolon	A type of aganglionic megacolon in which the aganglionic segment does not extend beyond the upper sigmoid.	UMLS:C4023431	hp.json		http://purl.obolibrary.org/obo/HP_0011284		
GO:0016798	biolink:MolecularActivity	hydrolase activity, acting on glycosyl bonds	Catalysis of the hydrolysis of any glycosyl bond.	EC:3.2.-.-|Reactome:R-HSA-2065233|Reactome:R-HSA-1793176	hp.json	glycosidase activity|N-glycosylase|glycosylase	http://purl.obolibrary.org/obo/GO_0016798		goslim_yeast|goslim_chembl|goslim_drosophila
GO:0016791	biolink:MolecularActivity	phosphatase activity	Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.	Reactome:R-HSA-9636457|MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN|Reactome:R-HSA-4419986|EC:3.1.3.-	hp.json	para-nitrophenyl phosphatase activity|4-nitrophenylphosphatase activity|p-nitrophenylphosphate phosphohydrolase activity|phosphatase|phosphoric monoester hydrolase activity|p-nitrophenylphosphatase activity|4-nitrophenylphosphate phosphohydrolase activity|K-pNPPase activity|PNPPase activity|ecto-p-nitrophenyl phosphatase activity|NPPase activity|nitrophenyl phosphatase activity	http://purl.obolibrary.org/obo/GO_0016791		goslim_candida|goslim_drosophila|goslim_chembl|goslim_metagenomics|goslim_yeast
HP:0011274	biolink:PhenotypicFeature	Recurrent mycobacterial infections	Increased susceptibility to mycobacterial infections, as manifested by recurrent episodes of mycobacterial infection.	UMLS:C4023438	hp.json		http://purl.obolibrary.org/obo/HP_0011274		
HP:0011275	biolink:PhenotypicFeature	Recurrent mycobacterium avium complex infections	Increased susceptibility to mycobacterial avium complex infections, as manifested by recurrent episodes of mycobacterial infection.	UMLS:C1737260	hp.json		http://purl.obolibrary.org/obo/HP_0011275		
HP:0011276	biolink:PhenotypicFeature	Vascular skin abnormality		SNOMEDCT_US:11263005|UMLS:C0162819|MSH:D017445|UMLS:C1842892	hp.json	Vascular abnormalities restricted to skin|Skin vascular malformation	http://purl.obolibrary.org/obo/HP_0011276		
HP:0011277	biolink:PhenotypicFeature	Abnormality of the urinary system physiology		UMLS:C4023437	hp.json		http://purl.obolibrary.org/obo/HP_0011277		
HP:0011278	biolink:PhenotypicFeature	Intrapulmonary sequestration	A type of pulmonary sequestration that occurs within the visceral pleura of normal lung tissue, usually without communication with the tracheobronchial tree.	UMLS:C4023436	hp.json		http://purl.obolibrary.org/obo/HP_0011278		
HP:0011279	biolink:PhenotypicFeature	Abnormality of urine bicarbonate level	An abnormal amount of hydrogencarbonate in the urine.	UMLS:C4023435	hp.json	Abnormality of urine HCO3 concentration	http://purl.obolibrary.org/obo/HP_0011279		
HP:0011270	biolink:PhenotypicFeature	Duplicated tragus	A complete or partial duplication of the tragus; expected to lie anterior to the normal tragus.	UMLS:C4021172	hp.json	Accesory tragus|Tragus, duplicated	http://purl.obolibrary.org/obo/HP_0011270		
HP:0011271	biolink:PhenotypicFeature	Prominent tragus	Increase posterolateral protrusion of the tragus.	UMLS:C4021171	hp.json	Hyperplastic tragus|Hypertrophic tragus|Large tragus|Enlarged tragus|Tragus, prominent	http://purl.obolibrary.org/obo/HP_0011271		hposlim_core
HP:0011272	biolink:PhenotypicFeature	Underdeveloped tragus	Decreased posterolateral protrusion of the tragus.	UMLS:C4013429	hp.json	Hypotrophic tragus|Small tragus|Hypoplastic tragus	http://purl.obolibrary.org/obo/HP_0011272		
HP:0011273	biolink:PhenotypicFeature	Anisocytosis	Abnormally increased variability in the size of erythrocytes.	SNOMEDCT_US:165475005|UMLS:C0221278|SNOMEDCT_US:57241006	hp.json	Unequal size of red blood cells	http://purl.obolibrary.org/obo/HP_0011273		
GO:0016769	biolink:MolecularActivity	transferase activity, transferring nitrogenous groups	Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor).	EC:2.6.-.-	hp.json	transferase activity, transferring other nitrogenous groups	http://purl.obolibrary.org/obo/GO_0016769		
CHEBI:51086	biolink:ChemicalSubstance	chemical role	A role played by the molecular entity or part thereof within a chemical context.		hp.json		http://purl.obolibrary.org/obo/CHEBI_51086		3_STAR
HP:0011263	biolink:PhenotypicFeature	Forward facing earlobe	Positioning of the anterior surface of the ear lobe in a more coronal plane than the remainder of the ear.	UMLS:C4021177	hp.json	Forward facing earlobe|Lobe, forward facing	http://purl.obolibrary.org/obo/HP_0011263		
HP:0011264	biolink:PhenotypicFeature	Discontinuous ascending root of helix	Interruption between the ascending helix and the crus helix, allowing the ascending helix to be attached directly to the mastoid.	UMLS:C4021176	hp.json	Helix, discontinuous ascending root	http://purl.obolibrary.org/obo/HP_0011264		
HP:0011265	biolink:PhenotypicFeature	Cleft earlobe	Discontinuity in the convexity of the inferior margin of the lobe.	UMLS:C4023440	hp.json	Cleft earlobe	http://purl.obolibrary.org/obo/HP_0011265		hposlim_core
HP:0011266	biolink:PhenotypicFeature	Microtia, first degree	Presence of all the normal ear components and the median longitudinal length more than two standard deviations below the mean.	UMLS:C4021175	hp.json	First-degree microtia	http://purl.obolibrary.org/obo/HP_0011266		
HP:0011267	biolink:PhenotypicFeature	Microtia, third degree	Presence of some auricular structures, but none of these structures conform to recognized ear components.	UMLS:C4021174|UMLS:C4280331	hp.json	Abnormal shape/structure of ear|Third-degree microtia	http://purl.obolibrary.org/obo/HP_0011267		
HP:0011268	biolink:PhenotypicFeature	Absent tragus	Lack of convexity or prominence of the contour of the ridge between the bottom of the incisura and the confluence of the ascending helix and crus helix.	UMLS:C4023439	hp.json		http://purl.obolibrary.org/obo/HP_0011268		hposlim_core
HP:0011269	biolink:PhenotypicFeature	Bifid tragus	Increased height of the tragal ridge with a shallow indentation at the apex, giving the appearance of a double peak.	UMLS:C4021173	hp.json	Tragus, bifid|Notched tragus	http://purl.obolibrary.org/obo/HP_0011269		
HP:0011260	biolink:PhenotypicFeature	Darwin notch of helix	Small defect of the helical fold that lies at the junction of the superior and descending portions of the helix.	UMLS:C4021180	hp.json	Helix, Darwin notch	http://purl.obolibrary.org/obo/HP_0011260		
HP:0011261	biolink:PhenotypicFeature	Darwin tubercle of helix	Small expansion of the helical fold at the junction of the superior and descending portions of the helix.	UMLS:C4021179	hp.json	Helix, Darwin tubercle	http://purl.obolibrary.org/obo/HP_0011261		
CHEBI:63046	biolink:ChemicalSubstance	emulsifier	The chemical role played by a substance that stabilizes an emulsion by increasing its kinetic stability.		hp.json	emulgent|emulgents|emulsifiers	http://purl.obolibrary.org/obo/CHEBI_63046		3_STAR
HP:0011262	biolink:PhenotypicFeature	Crimped helix	Linear, circumferential indentation in the convexity of the outer surface of the helix.	UMLS:C4021178	hp.json	Helix, crimped|Indented helix	http://purl.obolibrary.org/obo/HP_0011262		
GO:0016774	biolink:MolecularActivity	phosphotransferase activity, carboxyl group as acceptor	Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor).	EC:2.7.2.-	hp.json		http://purl.obolibrary.org/obo/GO_0016774		
GO:0016772	biolink:MolecularActivity	transferase activity, transferring phosphorus-containing groups	Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).	EC:2.7.-.-	hp.json		http://purl.obolibrary.org/obo/GO_0016772		goslim_chembl
UBERON:5003625	biolink:AnatomicalEntity	manual digit 5 plus metapodial segment	A subdivision of the autopod consisting of manual digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	manual digit 5 ( phalanges plus metapodial) plus soft tissue|manual digit 5 ray|manual digit V plus metapodial segment|manual digit 5|manual digit 5 digitopodial subdivision	http://purl.obolibrary.org/obo/UBERON_5003625		
UBERON:5003624	biolink:AnatomicalEntity	manual digit 4 plus metapodial segment	A subdivision of the autopod consisting of manual digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	manual digit 4 ( phalanges plus metapodial) plus soft tissue|manual digit 4 ray|manual digit IV plus metapodial segment|manual digit 4|manual digit 4 digitopodial subdivision	http://purl.obolibrary.org/obo/UBERON_5003624		
HP:0011410	biolink:PhenotypicFeature	Caesarian section	Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy).	SNOMEDCT_US:200144004|UMLS:C1384674	hp.json	Caesarian section	http://purl.obolibrary.org/obo/HP_0011410		
HP:0011411	biolink:PhenotypicFeature	Forceps delivery		UMLS:C0341808	hp.json	Forceps delivery	http://purl.obolibrary.org/obo/HP_0011411		
HP:0011412	biolink:PhenotypicFeature	Ventouse delivery	Delivery of newborn by means of a ventouse, a vacuum device used to assist the delivery of a baby when the second stage of labour has not progressed adequately.	SNOMEDCT_US:61586001|UMLS:C0042225|MSH:D014620|UMLS:C1456852|SNOMEDCT_US:10761101000119105|UMLS:C2825567	hp.json	Vacuum-assisted vaginal delivery|Vacuum extraction	http://purl.obolibrary.org/obo/HP_0011412		
UBERON:5003623	biolink:AnatomicalEntity	manual digit 3 plus metapodial segment	A subdivision of the autopod consisting of manual digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	manual digit 3 ( phalanges plus metapodial) plus soft tissue|manual digit III plus metapodial segment|manual digit 3 ray|manual digit 3|manual digit 3 digitopodial subdivision	http://purl.obolibrary.org/obo/UBERON_5003623		
UBERON:5003622	biolink:AnatomicalEntity	manual digit 2 plus metapodial segment	A subdivision of the autopod consisting of manual digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	manual digit II plus metapodial segment|manual digit 2 ( phalanges plus metapodial) plus soft tissue|manual digit 2 ray|manual digit 2|manual digit 2 digitopodial subdivision	http://purl.obolibrary.org/obo/UBERON_5003622		
HP:0011413	biolink:PhenotypicFeature	Shoulder dystocia	Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex.	SNOMEDCT_US:89700002|UMLS:C0269825	hp.json		http://purl.obolibrary.org/obo/HP_0011413		
GO:1905492	biolink:BiologicalProcess	positive regulation of branching morphogenesis of a nerve	Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve.		hp.json	up-regulation of branching morphogenesis of a nerve|activation of branching morphogenesis of a nerve|upregulation of branching morphogenesis of a nerve|up regulation of branching morphogenesis of a nerve	http://purl.obolibrary.org/obo/GO_1905492		
HP:0410225	biolink:PhenotypicFeature	Increased anti-drug IgE antibody level	Increased level of IgE antibody against a drug or class of drugs, such as antibiotics.		hp.json	Increased level of anti-drug IgE antibody	http://purl.obolibrary.org/obo/HP_0410225		
HP:0410224	biolink:PhenotypicFeature	Increased anti-bacteria IgE antibody level	Increased level of IgE antibody against bacteria.		hp.json	Increased level of anti-bacteria IgE antibody	http://purl.obolibrary.org/obo/HP_0410224		
HP:0410223	biolink:PhenotypicFeature	Increased anti-dust mite IgE antibody level	Increased level of IgE antibody against dust mites, such as house dust mites.		hp.json	Increased level of anti-dust mite IgE antibody	http://purl.obolibrary.org/obo/HP_0410223		
HP:0410222	biolink:PhenotypicFeature	Increased anti-seafood IgE antibody level	Increased level of IgE antibody against seafood, including fish, shrimp, lobster, crab, squid and abalone.		hp.json	Increased level of anti-seafood IgE antibody	http://purl.obolibrary.org/obo/HP_0410222		
HP:0410229	biolink:PhenotypicFeature	Increased anti-gluten IgE antibody level	Increased level of IgE antibody against gluten, a protein found in wheat, barley, and rye.		hp.json	Increased level of anti-gluten IgE antibody	http://purl.obolibrary.org/obo/HP_0410229		
HP:0410228	biolink:PhenotypicFeature	Increased anti-plant based food allergen IgE antibody level	Increased level of IgE antibody against a plant based food allergen, including vegetables and fruits.		hp.json	Increased level of anti-plant based food allergen IgE antibody	http://purl.obolibrary.org/obo/HP_0410228		
HP:0410227	biolink:PhenotypicFeature	Increased anti-food allergen IgE antibody level	Increased level of IgE antibody against proteins found in foods, such as milk, egg, soy, wheat, peanut, treenut, fish, and shellfish.		hp.json	Increased level of anti-food allergen IgE antibody	http://purl.obolibrary.org/obo/HP_0410227		
HP:0410226	biolink:PhenotypicFeature	Increased anti-feather IgE antibody level	Increased level of IgE antibody against feathers, which could be indicative of an allergy against feathers themselves, or mite allergens present in feathers.		hp.json		http://purl.obolibrary.org/obo/HP_0410226		
HP:0011414	biolink:PhenotypicFeature	Hydropic placenta	An abnormality of the placenta in which there are numerous cystic spaces within the placenta as well as placental enlargement.	SNOMEDCT_US:75094005|UMLS:C0270254	hp.json	Hydrops of the placenta	http://purl.obolibrary.org/obo/HP_0011414		
HP:0011415	biolink:PhenotypicFeature	Calcified placenta		UMLS:C0426234|SNOMEDCT_US:249174002	hp.json		http://purl.obolibrary.org/obo/HP_0011415		
HP:0011416	biolink:PhenotypicFeature	Placental infarction		SNOMEDCT_US:268585006|UMLS:C0554393	hp.json	Placental thromboembolism	http://purl.obolibrary.org/obo/HP_0011416		
HP:0011417	biolink:PhenotypicFeature	Long umbilical cord	Increased length of the umbilical cord.	UMLS:C0405028|SNOMEDCT_US:237261008	hp.json	Long umbilical cord	http://purl.obolibrary.org/obo/HP_0011417		
HP:0410221	biolink:PhenotypicFeature	Increased anti-animal protein IgE antibody level	Increased level of IgE antibody against animal proteins, such as albumins that are present in animal hair, dander, shed skin, saliva and urine.		hp.json	Increased level of anti-animal protein IgE antibody	http://purl.obolibrary.org/obo/HP_0410221		
HP:0011418	biolink:PhenotypicFeature	Abnormal insertion of umbilical cord	Anomalous location of the insertion of umbilical cord in the placenta. Normally, the insertion is at least two centimers distant from the edge of the placenta.	MSH:D055949|SNOMEDCT_US:79668009|UMLS:C0269852	hp.json		http://purl.obolibrary.org/obo/HP_0011418		
HP:0011419	biolink:PhenotypicFeature	Placental abruption	Separation of the placenta from the uterus wall before delivery.	SNOMEDCT_US:405736009|MSH:D000037|UMLS:C0000832|SNOMEDCT_US:415105001	hp.json	Abruptio placentae	http://purl.obolibrary.org/obo/HP_0011419		
HP:0410220	biolink:PhenotypicFeature	Increased anti-dairy protein IgE antibody level	Increased level of IgE antibody against dairy proteins, including casein, alpha-lactalbumin, beta-lactoglobulin or bovine serum albumin contained in cow, sheep or goat milk and milk products.		hp.json	Increased anti-dairy IgE antibody level	http://purl.obolibrary.org/obo/HP_0410220		
CHEBI:28616	biolink:ChemicalSubstance	carbamic acid	A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised.	CAS:463-77-4|PDBeChem:OUT|CAS:463-77-4|Beilstein:1734754|Wikipedia:Carbamic_acid|KEGG:C01563|Gmelin:130345|DrugBank:DB04261	hp.json	CARBAMIC ACID|Carbamate|Aminoameisensaeure|carbamic acid|Aminoformic acid|Carbamidsaeure|Carbamic acid	http://purl.obolibrary.org/obo/CHEBI_28616		3_STAR
HP:0011400	biolink:PhenotypicFeature	Abnormal CNS myelination	An abnormality of myelination of nerves in the central nervous system.	UMLS:C4021152	hp.json	Abnormal formation of myelin sheaths	http://purl.obolibrary.org/obo/HP_0011400		
HP:0011401	biolink:PhenotypicFeature	Delayed peripheral myelination	Delayed myelination in the peripheral nervous system.	UMLS:C4023374	hp.json		http://purl.obolibrary.org/obo/HP_0011401		
HP:0011402	biolink:PhenotypicFeature	Demyelinating sensory neuropathy	Demyelination of peripheral sensory nerves.	UMLS:C4023373	hp.json		http://purl.obolibrary.org/obo/HP_0011402		
HP:0410219	biolink:PhenotypicFeature	Hypoplasia of mandible relative to maxilla	Abnormally small dimension of the mandible (lower jaw) relative to the maxilla (upper jaw).		hp.json	Disorder of mandibular and maxillary dental arch relationship	http://purl.obolibrary.org/obo/HP_0410219		
HP:0410214	biolink:PhenotypicFeature	Hypercapnia in cord blood	Abnormally elevated blood carbon dioxide (CO2) level in the cord blood.		hp.json	High cord blood carbon dioxide level	http://purl.obolibrary.org/obo/HP_0410214		
HP:0410213	biolink:PhenotypicFeature	Hypoxemia in cord blood	An abnormally low level of blood oxygen in the cord blood.		hp.json	Low cord blood oxygen level	http://purl.obolibrary.org/obo/HP_0410213		
HP:0410212	biolink:PhenotypicFeature	Hyperoxemia in cord blood	An abnormally high level of blood oxygen in the cord blood.		hp.json	High cord blood oxygen level	http://purl.obolibrary.org/obo/HP_0410212		
HP:0410211	biolink:PhenotypicFeature	Abnormal blood gas level in cord blood			hp.json		http://purl.obolibrary.org/obo/HP_0410211		
HP:0410218	biolink:PhenotypicFeature	Hypoplasia of maxilla relative to mandible	Abnormally small dimension of the maxilla (upper jaw) relative to the mandible (lower jaw).		hp.json	Disorder of maxillary and mandibular dental arch relationship	http://purl.obolibrary.org/obo/HP_0410218		
HP:0410217	biolink:PhenotypicFeature	Reduced blood 5-methyltetrahydrofolate level	A decreased concentration of 5-methyltetrahydrofolate in the blood.		hp.json	Reduced serum methylfolate Level	http://purl.obolibrary.org/obo/HP_0410217		
HP:0410216	biolink:PhenotypicFeature	Abnormal blood 5-methyltetrahydrofolate level	An abnormal concentration of 5-methyltetrahydrofolate in the blood.		hp.json	Abnormal serum methylfolate Level	http://purl.obolibrary.org/obo/HP_0410216		
HP:0410215	biolink:PhenotypicFeature	Hypocapnia in cord blood	Abnormally decreased blood carbon dioxide (CO2) level in the cord blood.		hp.json	Low cord blood carbon dioxide level	http://purl.obolibrary.org/obo/HP_0410215		
HP:0011403	biolink:PhenotypicFeature	Abnormal umbilical cord blood vessel morphology		UMLS:C4023372	hp.json	Abnormal umbilical cord blood vessels	http://purl.obolibrary.org/obo/HP_0011403		
HP:0011404	biolink:PhenotypicFeature	Lethal short-trunk short stature	A type of disproportionate short stature characterized by a short trunk but a average-sized limbs that is lethal at birth.	UMLS:C4021151	hp.json	Lethal short-trunk dwarfism	http://purl.obolibrary.org/obo/HP_0011404		
HP:0011405	biolink:PhenotypicFeature	Childhood onset short-limb short stature		UMLS:C1867487	hp.json	Short-limb dwarfism identifiable during childhood	http://purl.obolibrary.org/obo/HP_0011405		
HP:0011406	biolink:PhenotypicFeature	Infancy onset short-trunk short stature	A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with onset in infancy.	UMLS:C1846061	hp.json	Short-trunk dwarfism, identifiable in infancy	http://purl.obolibrary.org/obo/HP_0011406		
HP:0410210	biolink:PhenotypicFeature	Abnormal cord blood measurement	An abnormality in any umbilical cord measurement performed after birth, such as the blood gas level.		hp.json		http://purl.obolibrary.org/obo/HP_0410210		
HP:0011407	biolink:PhenotypicFeature	Proportionate tall stature		UMLS:C4023371	hp.json		http://purl.obolibrary.org/obo/HP_0011407		
HP:0011408	biolink:PhenotypicFeature	Moderate intrauterine growth retardation	Intrauterine growth retardation that is at least 3 standard deviations (SD) below average, but not as low as 4 SD, corrected for sex and gestational age.	UMLS:C4023370	hp.json		http://purl.obolibrary.org/obo/HP_0011408		
HP:0011409	biolink:PhenotypicFeature	Abnormal placental membrane morphology	Structural anomaly of the fetal membranes (also known as the amniochorionic or placental membranes), which comprise a vital intrauterine compartment, where they perform mechanical, immune, and endocrine functions to promote growth of the fetus and protection from environmental adversity. Amniochorionic membranes anatomically consist of a single layer of cuboidal amnion epithelial cells, chorionic trophoblasts, and scattered fibroblasts connected by a layer of type IV collagen-rich extracellular matrix.	UMLS:C4023369	hp.json	Abnormality of placental membranes	http://purl.obolibrary.org/obo/HP_0011409		
HP:0410247	biolink:PhenotypicFeature	Increased anti-animal dander IgE antibody level	Increased level of IgE antibody against animal dander, tiny scales shed from animal skin or hair, such as from pet dogs or cats.		hp.json	Increased level of anti-dander IgE antibody	http://purl.obolibrary.org/obo/HP_0410247		
HP:0410246	biolink:PhenotypicFeature	Increased circulating IgD level	An abnormally increased level of immunoglobulin D in blood.		hp.json	Increased serum IgD|Increased levels of IgD|Elevated IgD|Increased IgD level|IgD hypergammaglobulinemia|Elevated serum IgD	http://purl.obolibrary.org/obo/HP_0410246		
HP:0410245	biolink:PhenotypicFeature	Decreased circulating IgD	An abnormally decreased level of immunoglobulin D (IgD) in blood.		hp.json	Decreased IgD|IgD deficiency|Decreased IgD in blood	http://purl.obolibrary.org/obo/HP_0410245		
HP:0410244	biolink:PhenotypicFeature	Abnormal circulating IgD level	An abnormal deviation from normal levels of IgD immunoglobulin in blood.		hp.json	Abnormal IgD level in blood	http://purl.obolibrary.org/obo/HP_0410244		
HP:0410249	biolink:PhenotypicFeature	Increased anti-alpha-gal IgE antibody level	Increased level of IgE antibody against galactose-alpha-1, 3 galactose (alpha-gal), a carbohydrate found in mammalian meat.		hp.json	Increased anti-galactose-alpha-1, 3 galactose IgE antibody level	http://purl.obolibrary.org/obo/HP_0410249		
HP:0410248	biolink:PhenotypicFeature	Increased anti-house dust mite IgE antibody level	Increased level of IgE antibody against house dust mites, a common allergen.		hp.json	Increased anti-house dust IgE antibody level|Increased level of anti-house dust IgE antibody	http://purl.obolibrary.org/obo/HP_0410248		
HP:0410243	biolink:PhenotypicFeature	Abnormal circulating IgM level	An abnormal deviation from normal levels of IgM immunoglobulin in blood.		hp.json	Abnormal IgM level in blood	http://purl.obolibrary.org/obo/HP_0410243		
HP:0410242	biolink:PhenotypicFeature	Abnormal circulating IgG level	An abnormal deviation from normal levels of IgG immunoglobulin in blood.		hp.json	Abnormal IgG level in blood	http://purl.obolibrary.org/obo/HP_0410242		
HP:0410241	biolink:PhenotypicFeature	Abnormal circulating IgE level	An abnormal deviation from normal levels of IgE immunoglobulin in blood.		hp.json	Abnormal IgE level in blood	http://purl.obolibrary.org/obo/HP_0410241		
HP:0410240	biolink:PhenotypicFeature	Abnormal circulating IgA level	An abnormal deviation from normal levels of IgA immunoglobulin in blood.		hp.json	Abnormal IgA level in blood	http://purl.obolibrary.org/obo/HP_0410240		
GO:2000818	biolink:BiologicalProcess	negative regulation of myoblast proliferation	Any process that stops, prevents or reduces the frequency, rate or extent of myoblast proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_2000818		
HP:0410236	biolink:PhenotypicFeature	Increased anti-venom IgE antibody level	Increased level of IgE antibody against venom from insects such as bees, wasps, hornets, yellowjackets.		hp.json		http://purl.obolibrary.org/obo/HP_0410236		
HP:0410235	biolink:PhenotypicFeature	Increased anti-insect IgE antibody level	Increased level of IgE antibody against antigens from insects such as moths, mosquitos, or cockroaches.		hp.json		http://purl.obolibrary.org/obo/HP_0410235		
HP:0410234	biolink:PhenotypicFeature	Increased anti-parasite IgE antibody level	Increased level of IgE antibody against parasites, such as helminths (parasitic worms, such as Ascaris lumbricoides, Trichuris trichiura, Ancylostoma duodenalis, Necator americanus, Strongyloides stercoralis) or parasites such as Toxoplasma gondii.		hp.json		http://purl.obolibrary.org/obo/HP_0410234		
HP:0410233	biolink:PhenotypicFeature	Increased anti-meat allergen IgE antibody level	Increased level of IgE antibody against meat, such as mammalian meat, including beef or pork, or poultry, like duck or chicken.		hp.json		http://purl.obolibrary.org/obo/HP_0410233		
HP:0410239	biolink:PhenotypicFeature	Positive urine norcotinine test	Detection of norcotinine, a metabolite of nicotine, in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410239		
HP:0410238	biolink:PhenotypicFeature	Increased anti-plant product IgE antibody level	Increased level of IgE antibody against antigens from plants and products derived from plants, such as wood or pollen.		hp.json		http://purl.obolibrary.org/obo/HP_0410238		
HP:0410232	biolink:PhenotypicFeature	Increased anti-fungi IgE antibody level	Increased level of IgE antibody against fungus, such as molds like zygomycota, ascomycota and deuteromycota.		hp.json	Increased anti-fungal IgE antibody level|Increased anti-fungus IgE antibody level	http://purl.obolibrary.org/obo/HP_0410232		
HP:0410231	biolink:PhenotypicFeature	Increased anti-egg IgE antibody level	Increased level of IgE antibody against eggs, including egg whites, egg yolks, and egg proteins such as ovoalbumin and ovomucoid.		hp.json		http://purl.obolibrary.org/obo/HP_0410231		
CARO:0000000	biolink:NamedThing	anatomical entity			hp.json		http://purl.obolibrary.org/obo/CARO_0000000		
HP:0410230	biolink:PhenotypicFeature	Increased anti-nut food product IgE antibody level	Increased level of IgE antibody against nut food products such as peanuts or tree nuts, such as hazelnuts, walnuts, cashews, and almonds.		hp.json		http://purl.obolibrary.org/obo/HP_0410230		
CARO:0000003	biolink:NamedThing	connected anatomical structure			hp.json		http://purl.obolibrary.org/obo/CARO_0000003		
HP:0011450	biolink:PhenotypicFeature	Unusual CNS infection	A type of infection of the central nervous system that can be regarded as a sign of a pathological susceptibility to infection.	MSH:D002494|UMLS:C0007684|SNOMEDCT_US:128117002	hp.json	Central nervous system infection	http://purl.obolibrary.org/obo/HP_0011450		
HP:0011451	biolink:PhenotypicFeature	Primary microcephaly	Head circumference below 2 standard deviations below the mean for age and gender at birth.	UMLS:C4020749|UMLS:C2677180	hp.json	Congenital microcephaly|Small head present at birth|Decreased head circumference present at birth|Small cranium present at birth|Head circumference small for gestational age|Congenital small head|Congenital small head circumference|Small skull present at birth|Congenital small skull|Microcephaly present at birth|Congenital decreased head circumference|Small head circumference present at birth	http://purl.obolibrary.org/obo/HP_0011451		
HP:0011452	biolink:PhenotypicFeature	Functional abnormality of the middle ear	An abnormality of the function of the middle ear.	UMLS:C4021846	hp.json	Functional abnormality of the middle ear	http://purl.obolibrary.org/obo/HP_0011452		
HP:0011453	biolink:PhenotypicFeature	Abnormality of the incus	An abnormality of the incus, an ossicle in the middle ear.	UMLS:C4023350	hp.json		http://purl.obolibrary.org/obo/HP_0011453		
CARO:0000006	biolink:NamedThing	material anatomical entity			hp.json		http://purl.obolibrary.org/obo/CARO_0000006		
HP:0011454	biolink:PhenotypicFeature	Abnormality of the malleus	An abnormality of the malleus, an ossicle in the middle ear.	UMLS:C4023349	hp.json		http://purl.obolibrary.org/obo/HP_0011454		
HP:0011455	biolink:PhenotypicFeature	Absent malleus	Aplasia of the malleus.	SNOMEDCT_US:300169003|UMLS:C0576900	hp.json		http://purl.obolibrary.org/obo/HP_0011455		
HP:0011456	biolink:PhenotypicFeature	Absent stapes	Aplasia of the stapes.	UMLS:C0576909|SNOMEDCT_US:300178009	hp.json		http://purl.obolibrary.org/obo/HP_0011456		
HP:0011457	biolink:PhenotypicFeature	Loss of eyelashes	This term refers to the loss of eyelashes that were previously present.	SNOMEDCT_US:34887006|UMLS:C0271321	hp.json	Eyelashes fell out|Missing eyelashes|Milphosis|Ciliary Madarosis|Loss of eyelashes	http://purl.obolibrary.org/obo/HP_0011457		
HP:0410269	biolink:PhenotypicFeature	Labial hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the upper lip.		hp.json		http://purl.obolibrary.org/obo/HP_0410269		
HP:0410268	biolink:PhenotypicFeature	Spleen hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the spleen.		hp.json	Splenic hemangioma	http://purl.obolibrary.org/obo/HP_0410268		
HP:0410267	biolink:PhenotypicFeature	Intestinal hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, located in the intestines, which includes the bowel.		hp.json	Intestinal hemangiomas|Bowel hemangioma	http://purl.obolibrary.org/obo/HP_0410267		
HP:0410266	biolink:PhenotypicFeature	Visceral hemangioma	A hemangioma arising from within visceral structures, the internal organs of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0410266		
HP:0410261	biolink:PhenotypicFeature	Wide space between 4th and 5th toe	A widely spaced gap between the fourth toe and the fifth (pinky) toe.		hp.json	Wide space between the 4th and 5th toe	http://purl.obolibrary.org/obo/HP_0410261		
HP:0011458	biolink:PhenotypicFeature	Abdominal symptom	A subjective manifestation of disease localized to the abdomen.	UMLS:C0740651	hp.json		http://purl.obolibrary.org/obo/HP_0011458		
HP:0410260	biolink:PhenotypicFeature	Asymmetrical gluteal crease	The presence of an asymmetrical gluteal crease, the horizontal crease formed by the inferior aspect of the buttocks and the posterior upper leg.		hp.json	Asymmetrical gluteal sulcus|Asymmetrical buttock crease|Asymmetrical horizontal gluteal crease	http://purl.obolibrary.org/obo/HP_0410260		
HP:0011459	biolink:PhenotypicFeature	Esophageal carcinoma	The presence of a carcinoma of the esophagus.	SNOMEDCT_US:372138000|UMLS:C0152018	hp.json		http://purl.obolibrary.org/obo/HP_0011459		
HP:0410265	biolink:PhenotypicFeature	Supraglottic hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, located in the upper part of the larynx (voice box) including the epiglottis; the area above the vocal cords.		hp.json		http://purl.obolibrary.org/obo/HP_0410265		
HP:0410264	biolink:PhenotypicFeature	Subglottic hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, located in the airway, typically below the vocal chords, that can cause severe obstruction of the airway.		hp.json	Airway hemangioma	http://purl.obolibrary.org/obo/HP_0410264		
HP:0410263	biolink:PhenotypicFeature	Brain imaging abnormality	An anomaly of metabolism or structure of the brain identified by imaging.		hp.json	Abnormal brain imaging	http://purl.obolibrary.org/obo/HP_0410263		
HP:0410262	biolink:PhenotypicFeature	Lower cranial nerve dysfunction	A functional abnormality affecting the lower cranial nerves, which include the paired 9th (glossopharyngeal), 10th (vagal), 11th (accessory) and 12th (hypoglossal) cranial nerves.		hp.json	Abnormal lower cranial nerve function	http://purl.obolibrary.org/obo/HP_0410262		
HP:0011440	biolink:PhenotypicFeature	Alcohol-induced rhabdomyolysis	Rhabdomyolysis induced by intake of alcohol.	UMLS:C4023355	hp.json		http://purl.obolibrary.org/obo/HP_0011440		
HP:0011441	biolink:PhenotypicFeature	Abnormal medulla oblongata morphology	An abnormality of the medulla oblongata, the lower half of the brainstem.	UMLS:C4021148	hp.json	Abnormality of the medulla oblongata|Abnormality of the myencephalon	http://purl.obolibrary.org/obo/HP_0011441		
HP:0011442	biolink:PhenotypicFeature	Abnormal central motor function	An anomaly of the control or production of movement in the central nervous system.	UMLS:C4023354	hp.json	Abnormality of central motor function	http://purl.obolibrary.org/obo/HP_0011442		
HP:0011443	biolink:PhenotypicFeature	Abnormality of coordination		UMLS:C4023353	hp.json	Coordination issue|Abnormality of coordination	http://purl.obolibrary.org/obo/HP_0011443		
HP:0011444	biolink:PhenotypicFeature	Decorticate rigidity	A type of rigidity in which the arms are in flexion and adduction and the legs are extended. This signifies a lesion in the cerebral white matter, internal capsules, or thalamus.	UMLS:C0231521|SNOMEDCT_US:36423000|MSH:D003655	hp.json		http://purl.obolibrary.org/obo/HP_0011444		
HP:0011445	biolink:PhenotypicFeature	Athetoid cerebral palsy	A type of cerebral palsy characterized by slow, involuntary muscle movement and mixed muscle tone.	SNOMEDCT_US:75019001|UMLS:C0270742|MSH:D002547|SNOMEDCT_US:230780007	hp.json	Dyskinetic cerebral palsy	http://purl.obolibrary.org/obo/HP_0011445		
HP:0011446	biolink:PhenotypicFeature	Abnormality of higher mental function	Cognitive, psychiatric or memory anomaly.	UMLS:C4023352	hp.json		http://purl.obolibrary.org/obo/HP_0011446		
HP:0410258	biolink:PhenotypicFeature	Neutrophilia in absence of infection	An increased number of neutrophils circulating in the blood in the absence of an infection. Factors contributing to neutrophilia could include inflammation or congenital disorders.		hp.json		http://purl.obolibrary.org/obo/HP_0410258		
HP:0410257	biolink:PhenotypicFeature	Neutrophilia in presence of infection	An increased number of neutrophils circulating in the blood during an infection, such as with a bacteria, virus or fungus.		hp.json		http://purl.obolibrary.org/obo/HP_0410257		
HP:0410256	biolink:PhenotypicFeature	Infection associated neutropenia	Transient neutropenia caused by an infection, such as with a virus, bacteria or protozoan.		hp.json		http://purl.obolibrary.org/obo/HP_0410256		
HP:0410255	biolink:PhenotypicFeature	Transient neutropenia	A transient reduction in the number of neutrophils in the peripheral blood. Transient neutropenia is most commonly associated with viral infections, but other causes include drugs and autoimmunity.		hp.json		http://purl.obolibrary.org/obo/HP_0410255		
HP:0410259	biolink:PhenotypicFeature	Hepatopulmonary fusion	Fusion of the liver with the lung.		hp.json	Hepatic pulmonary fusion	http://purl.obolibrary.org/obo/HP_0410259		
HP:0011447	biolink:PhenotypicFeature	Hyposegmentation of neutrophil nuclei	Hyposegmented (hypolobulated) or bilobed neutrophil nuclei.	SNOMEDCT_US:85559002|UMLS:C4023351|MSH:D010381|UMLS:C0030779	hp.json	Hyposegmentation of neutrophil nuclei in peripheral blood|Pelger-Huet anomaly	http://purl.obolibrary.org/obo/HP_0011447		
HP:0011448	biolink:PhenotypicFeature	Ankle clonus	Clonus is an involuntary tendon reflex that causes repeated flexion and extension of the foot. Ankle clonus is tested by rapidly flexing the foot upward.	SNOMEDCT_US:39055007|UMLS:C0238651	hp.json	Abnormal rhythmic movements of ankle	http://purl.obolibrary.org/obo/HP_0011448		
HP:0011449	biolink:PhenotypicFeature	Knee clonus	Clonus is an involuntary tendon reflex that causes repeated flexion and extension of the foot. Knee clonus can be tested by rapidly pushing the patella towards the toes.	UMLS:C0520823|SNOMEDCT_US:54360005	hp.json	Patellar clonus	http://purl.obolibrary.org/obo/HP_0011449		
HP:0410254	biolink:PhenotypicFeature	Cyclic neutropenia in myeloid maturation arrest in bone marrow	Cyclic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow.		hp.json		http://purl.obolibrary.org/obo/HP_0410254		
HP:0410253	biolink:PhenotypicFeature	Myeloid maturation arrest	Chornic neutropenia arising from an impaired proliferation and maturation of myeloid progenitor cells in the bone marrow.		hp.json	Myeloid maturation arrest in bone marrow	http://purl.obolibrary.org/obo/HP_0410253		
HP:0410252	biolink:PhenotypicFeature	Chronic neutropenia	Neutropenia with an absolute neutrophil count (ANC) less than 1,500,000,000/L lasting for more than 3 months.		hp.json		http://purl.obolibrary.org/obo/HP_0410252		
HP:0410251	biolink:PhenotypicFeature	Abnormal L-selectin shedding	An abnormality in the cleavage of L-selectin during the process of guiding neutrophils to the site of infection. Proteolytic cleavage of L-selectin results in rapid shedding from the cell surface, which has a role in neutrophil rolling and accumulation at the site of infection.		hp.json		http://purl.obolibrary.org/obo/HP_0410251		
HP:0011430	biolink:PhenotypicFeature	Hypoplasia of fetal nasal bone	On prenatal ultrasound, the nasal bone is a thin echogenic line within the bridge of the fetal nose. The fetus is imaged facing the transducer with the fetal face strictly in the midline. The angle of insonation is 90 degrees, with the longitudinal axis of the nasal bone as the reference line. Calibres are placed at each end of the nasal bone. Absence of the nasal bone or measurements below 2.5th percentile are considered significant (PMID:16100637).	UMLS:C4023363	hp.json	Underdeveloped fetal nose bone|Hypoplasia of foetal nasal bone|Underdeveloped foetal nose bone	http://purl.obolibrary.org/obo/HP_0011430		
HP:0011431	biolink:PhenotypicFeature	Fetal fifth finger clinodactyly	Fifth finger clinodactyly is defined by a hypoplastic or absent mid-phalanx of the fifth digit. Ultrasound identification of the fetal hand must first be undertaken and then appropriate magnification accomplished. The evaluation requires stretching of the 5 fingers. The diagnosis is established when the middle phalanx of the fifth finger is markedly smaller than normal or absent, which often causes the finger to be curved inward (PMID:16100637).	UMLS:C4023362|UMLS:C4280326	hp.json	Foetal pinkie finger curvature|Foetal little finger curvature|Foetal fifth finger clinodactyly|Foetal pinky finger curvature|Fetal pinkie finger curvature|Fetal pinky finger curvature|Fetal little finger curvature	http://purl.obolibrary.org/obo/HP_0011431		
HP:0011432	biolink:PhenotypicFeature	High maternal circulating alpha-fetoprotein concentration	Increase in the levels of maternal serum alpha-fetoprotein levels during pregnancy.	UMLS:C4023361	hp.json	Increased maternal serum alpha-fetoprotein level|High maternal serum alpha-fetoprotein|MSAFP MoM>2.5|High maternal serum alpha-fetoprotein MoM|High MSAFP MoM	http://purl.obolibrary.org/obo/HP_0011432		
HP:0410290	biolink:PhenotypicFeature	Positive urine norpropoxyphene test	Detection of norpropoxyphene in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410290		
HP:0011433	biolink:PhenotypicFeature	High maternal circulating chorionic gonadotropin concentration	An abnormally high concentration of maternal serum human chorionic gonadotropin as compared to normal values for gestational-age.	UMLS:C4021150	hp.json	High maternal serum hCG|High maternal serum chorionic gonadotropin	http://purl.obolibrary.org/obo/HP_0011433		
HP:0011434	biolink:PhenotypicFeature	Low maternal circulating chorionic gonadotropin concentration	An abnormally low concentration of maternal serum human chorionic gonadotropin as compared to normal values for gestational-age.	UMLS:C4021149	hp.json	Low maternal serum chorionic gonadotropin|Low maternal serum hCG	http://purl.obolibrary.org/obo/HP_0011434		
HP:0011435	biolink:PhenotypicFeature	Low maternal circulating PAPP-A concentration	An abnormally low concentration of serum PAPP-A (pregnancy associated plasma protein A), as compared to normal values for gestational-age.	UMLS:C4023360	hp.json	Low maternal serum PAPP-A	http://purl.obolibrary.org/obo/HP_0011435		
HP:0410289	biolink:PhenotypicFeature	Hypoamylasemia	Decreased level of amylase in the blood, an enzyme which helps digest glycogen and starch. It is produced mainly in the pancreas and salivary glands.		hp.json	Decreased circulating amylase level	http://purl.obolibrary.org/obo/HP_0410289		
HP:0410288	biolink:PhenotypicFeature	Hyperamylasemia	Increased level of amylase in the blood, an enzyme which helps digest glycogen and starch. It is produced mainly in the pancreas and salivary glands.		hp.json	Increased circulating amylase level	http://purl.obolibrary.org/obo/HP_0410288		
HP:0410283	biolink:PhenotypicFeature	Positive blood acetaminophen test	Detection of acetaminophen in the blood.		hp.json	Positive blood paracetamol test|Positive blood Tylenol test	http://purl.obolibrary.org/obo/HP_0410283		
HP:0011436	biolink:PhenotypicFeature	Abnormal maternal serum screening	An abnormally elevated or decreased level of a maternal serum marker analytes used in screening for aneuploidy.	UMLS:C4023359	hp.json		http://purl.obolibrary.org/obo/HP_0011436		
HP:0011437	biolink:PhenotypicFeature	Maternal autoimmune disease	A medical history of a fetus or child born to a mother with an autoimmune disease.	UMLS:C4023358	hp.json		http://purl.obolibrary.org/obo/HP_0011437		
HP:0410282	biolink:PhenotypicFeature	Abnormal circulating amylase level	A deviation from the normal concentration of amylase in the blood, an enzyme which helps digest glycogen and starch. It is produced mainly in the pancreas and salivary glands.		hp.json		http://purl.obolibrary.org/obo/HP_0410282		
HP:0011438	biolink:PhenotypicFeature	Maternal teratogenic exposure	A medical history of exposure of the mother of a child or fetus to a teratogenic substance during pregnancy.	UMLS:C4023357	hp.json		http://purl.obolibrary.org/obo/HP_0011438		
HP:0410281	biolink:PhenotypicFeature	Dyspepsia	A heterogeneous group of symptoms that are localized in the epigastric region. Typical dyspeptic symptoms include postprandial fullness, early satiation, epigastric pain and epigastric burning, but other upper gastrointestinal symptoms such as nausea, belching or abdominal bloating often occur.		hp.json	Indigestion	http://purl.obolibrary.org/obo/HP_0410281		
HP:0410280	biolink:PhenotypicFeature	Pediatric onset	Onset of disease manifestations before adulthood, defined here as before the age of 15 years, but excluding neonatal or congenital onset.		hp.json	Paediatric onset|Onset before adulthood	http://purl.obolibrary.org/obo/HP_0410280		
HP:0011439	biolink:PhenotypicFeature	Anesthetic-induced rhabdomylosis	Rhabdomyolysis induced by anesthesia.	UMLS:C4023356	hp.json		http://purl.obolibrary.org/obo/HP_0011439		
HP:0410287	biolink:PhenotypicFeature	Intrathoracic hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the intrathoracic or chest region.		hp.json	Chest hemangioma	http://purl.obolibrary.org/obo/HP_0410287		
HP:0410286	biolink:PhenotypicFeature	Positive blood molindone test	Detection of molindone in the blood, an antipyschotic used for treatment of schizophrenia.		hp.json	Positive blood Moban test	http://purl.obolibrary.org/obo/HP_0410286		
HP:0410285	biolink:PhenotypicFeature	Positive meconium methadone test	Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in meconium.		hp.json		http://purl.obolibrary.org/obo/HP_0410285		
HP:0410284	biolink:PhenotypicFeature	Positive norpropoxyphene blood test	Detection of norpropoxyphene in the blood, a major metabolite of the opioid analgesic drug dextropropoxyphene.		hp.json		http://purl.obolibrary.org/obo/HP_0410284		
HP:0011420	biolink:PhenotypicFeature	Age of death	The age group when the cessation of life happens.	UMLS:C1546180	hp.json		http://purl.obolibrary.org/obo/HP_0011420		
HP:0011421	biolink:PhenotypicFeature	Death in adolescence	Death during adolescence, the period between childhood and adulthood (roughly between the ages of 10 and 19 years).	UMLS:C4023368	hp.json	Death in adolescence	http://purl.obolibrary.org/obo/HP_0011421		
HP:0011422	biolink:PhenotypicFeature	Abnormal blood chloride concentration	An abnormality of chloride homeostasis or concentration in the body.	UMLS:C4023367	hp.json	Abnormality of chloride homeostasis|Abnormal blood Cl concentration|Abnormal blood Cl- concentration	http://purl.obolibrary.org/obo/HP_0011422		
HP:0011423	biolink:PhenotypicFeature	Hyperchloremia	An abnormally increased chloride concentration in the blood.	SNOMEDCT_US:74450001|UMLS:C0085679	hp.json		http://purl.obolibrary.org/obo/HP_0011423		
HP:0011424	biolink:PhenotypicFeature	Increased serum zinc	An increased consentration of zinc in the blood.	UMLS:C0856208|UMLS:C0854520	hp.json	Hyperzincemia	http://purl.obolibrary.org/obo/HP_0011424		
HP:0410279	biolink:PhenotypicFeature	Atrophic pituitary gland	Partial or complete wasting (loss) of the pituitary gland.		hp.json	Pituitary gland atrophy|Atrophic pituitary	http://purl.obolibrary.org/obo/HP_0410279		
HP:0410278	biolink:PhenotypicFeature	Pituitary gland cyst	A fluid-filled sacs that develop on or near the pituitary gland.		hp.json	Cyst of the pituitary gland	http://purl.obolibrary.org/obo/HP_0410278		
HP:0410277	biolink:PhenotypicFeature	Sternal pit	A sternal pit is a small indentation or dimple in the skin overlying the sternum of the chest. In some cases, the skin defect can be linear, extending several inches over the sternum.		hp.json		http://purl.obolibrary.org/obo/HP_0410277		
HP:0011425	biolink:PhenotypicFeature	Fetal ultrasound soft marker	An finding upon obstetric ultrasound examination performed at around 16 to 20 weeks of gestation that is abnormal but not clearly identifiable as a fetal anatomic malformation or growth restriction. Such findings are known as soft markers since they are associated with increased risk for fetal aneuploidy or other disorders.	UMLS:C4023366	hp.json	Foetal ultrasound soft marker	http://purl.obolibrary.org/obo/HP_0011425		
HP:0410272	biolink:PhenotypicFeature	Vulvar hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the vulva.		hp.json		http://purl.obolibrary.org/obo/HP_0410272		
HP:0011426	biolink:PhenotypicFeature	Fetal choroid plexus cysts	Fetal choroid plexus cysts (CPCs) are sonographically discrete, small cysts found in the choroid plexus within the lateral cerebral ventricles of the developing fetus at 14 to 24 weeks gestation. Imaging of the choroid plexus is performed in the transverse plane of the fetal head at the same level that the lateral cerebral ventricle is evaluated. The choroid plexus should be inspected bilaterally for the presence of cysts. The size of CPCs is not of clinical relevance (PMID:16100637).	SNOMEDCT_US:462165005|UMLS:C3532166	hp.json	Foetal choroid plexus cysts	http://purl.obolibrary.org/obo/HP_0011426		
HP:0410271	biolink:PhenotypicFeature	Laryngeal hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the glottic or supraglottic regions.		hp.json	Throat hemangioma	http://purl.obolibrary.org/obo/HP_0410271		
HP:0410270	biolink:PhenotypicFeature	Esophageal hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the esophagus.		hp.json		http://purl.obolibrary.org/obo/HP_0410270		
HP:0011427	biolink:PhenotypicFeature	Enlarged fetal cisterna magna	The cisterna magna is measured on a transaxial view of the fetal head angled 15 degrees caudal to the canthomeatal line. The anterior/posterior diameter is taken between the inferior/posterior surface of the vermis of the cerebellum to the inner surface of the cranium. An enlarged cisternal magna is defined by an anterior/posterior diameter of 10 mm or more (PMID:16100637).	UMLS:C4023365	hp.json	Enlarged foetal cisterna magna	http://purl.obolibrary.org/obo/HP_0011427		
HP:0011428	biolink:PhenotypicFeature	Short fetal femur length	A short femur length is defined as either a measurement below the 2.5th percentile for gestational age or a measurement that is less than 0.9 of that predicted by the measured biparietal diameter. The femur should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (PMID:16100637).	UMLS:C0743924	hp.json	Short foetal femur length|Short foetal thigh bone length|Short fetal thigh bone length	http://purl.obolibrary.org/obo/HP_0011428		
HP:0011429	biolink:PhenotypicFeature	Short fetal humerus length	A short humerus length is defined as a length below the 2.5th percentile for gestational age or as a measurement less than 0.9 of that predicted by the measured biparietal diameter. The humerus should be measured with the bone perpendicular to the ultrasound beam and with epiphyseal cartilages visible but not included in the measurement (PMID:16100637).	UMLS:C4023364	hp.json	Short foetal humerus length|Short foetal long bone in upper arm length|Short fetal long bone in upper arm length	http://purl.obolibrary.org/obo/HP_0011429		
HP:0410276	biolink:PhenotypicFeature	Supraumbilical raphe	An abnormality of the sternum that presents at birth as a ventral sternal non-union defect, due to an abnormality of the fusion of the layers of the skin. It presents as a scar-like line that extends upward from the umbilicus (belly button).		hp.json	Midline supraumbilical raphe	http://purl.obolibrary.org/obo/HP_0410276		
HP:0410275	biolink:PhenotypicFeature	Lumbosacral hemangioma	A spinal cord hemangioma located in the lumbosacral spine region.		hp.json	Lumbar/sacral hemangioma	http://purl.obolibrary.org/obo/HP_0410275		
HP:0410274	biolink:PhenotypicFeature	Paraspinal hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the paraspinal muscular region, the muscles next to the spine.		hp.json		http://purl.obolibrary.org/obo/HP_0410274		
HP:0410273	biolink:PhenotypicFeature	Retropharyngeal hemangioma	A hemangioma, a benign tumor of the vascular endothelial cells, that is located in the retropharyngeal space, the portion of the peripharyngeal space that is located posterior to the pharynx.	NCIT:C3085	hp.json		http://purl.obolibrary.org/obo/HP_0410273		
GO:0051236	biolink:BiologicalProcess	establishment of RNA localization	The directed movement of RNA to a specific location.		hp.json	establishment of RNA localisation|RNA recruitment|RNA positioning	http://purl.obolibrary.org/obo/GO_0051236		
GO:0051234	biolink:BiologicalProcess	establishment of localization	Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation.		hp.json	establishment of localisation	http://purl.obolibrary.org/obo/GO_0051234		goslim_pir|goslim_flybase_ribbon|goslim_mouse|goslim_agr
CHEBI:28689	biolink:ChemicalSubstance	dehydroepiandrosterone	An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.	CAS:53-43-0|PMID:24256992|CAS:53-43-0|Drug_Central:795|LIPID_MAPS_instance:LMST02020021|PMID:14662261|PMID:24424045|HMDB:HMDB0000077|Reaxys:2058110|Wikipedia:Dehydroepiandrosterone|MetaCyc:3-BETA-HYDROXYANDROST-5-EN-17-ONE|KEGG:C01227|DrugBank:DB01708|KEGG:D08409|PDBeChem:AND|PMID:18634257	hp.json	3-BETA-HYDROXY-5-ANDROSTEN-17-ONE|DHEA|DHA|3beta-Hydroxyandrost-5-en-17-one|Dehydroisoandrosterone|Dehydroepiandrosterone|Prasterone|Intrarosa|3beta-hydroxyandrost-5-en-17-one|3beta-hydroxyandrost-5-en-17-one|3beta-hydroxyandrost-5-en-17-one	http://purl.obolibrary.org/obo/CHEBI_28689		3_STAR
GO:0051239	biolink:BiologicalProcess	regulation of multicellular organismal process	Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.		hp.json		http://purl.obolibrary.org/obo/GO_0051239		
GO:0016903	biolink:MolecularActivity	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.	EC:1.2.-.-	hp.json	oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors	http://purl.obolibrary.org/obo/GO_0016903		
CHEBI:26020	biolink:ChemicalSubstance	phosphate	Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom.		hp.json	phosphates|phosphates	http://purl.obolibrary.org/obo/CHEBI_26020		3_STAR
GO:2000860	biolink:NamedThing	positive regulation of aldosterone secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000860		
UBERON:0008460	biolink:AnatomicalEntity	prezygapophysis of thoracic vertebra	A prezygapophysis that is part of a thoracic vertebra.	FMA:9155	hp.json	superior apophyseal process|cranial articular process of thoracic vertebra|processus articularis (zygapophysis) thoracicus superior|superior articular process of thoracic vertebra|superior zygapophysis	http://purl.obolibrary.org/obo/UBERON_0008460		
NCBITaxon:6960	biolink:OrganismalEntity	Hexapoda		GC_ID:1	hp.json	Uniramia|Atelocerata|Tracheata|insects|hexapods	http://purl.obolibrary.org/obo/NCBITaxon_6960		
UBERON:0008461	biolink:AnatomicalEntity	postzygapophysis of lumbar vertebra	An postzygapophysis that is part of a lumbar vertebra.	FMA:16127	hp.json	inferior articular process of lumbar vertebra|caudal articular process of lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0008461		
UBERON:0008462	biolink:AnatomicalEntity	postzygapophysis of cervical vertebra	An postzygapophysis that is part of a cervical vertebra.	FMA:23970	hp.json	inferior articular process of cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0008462		
UBERON:0008463	biolink:AnatomicalEntity	postzygapophysis of thoracic vertebra	An postzygapophysis that is part of a thoracic vertebra.	FMA:9156	hp.json	inferior apophyseal process|processus articularis (zygapophysis) thoracicus inferior|inferior articular process of thoracic vertebra|inferior zygapophysis|caudal articular process of thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0008463		
GO:0051247	biolink:BiologicalProcess	positive regulation of protein metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.		hp.json	stimulation of cellular protein metabolic process|up-regulation of cellular protein metabolic process|activation of cellular protein metabolic process|positive regulation of cellular protein metabolism|up-regulation of protein metabolic process|positive regulation of protein metabolism|upregulation of cellular protein metabolic process|up regulation of protein metabolic process|activation of protein metabolic process|positive regulation of cellular protein metabolic process|stimulation of protein metabolic process|up regulation of cellular protein metabolic process|upregulation of protein metabolic process	http://purl.obolibrary.org/obo/GO_0051247		
GO:0051248	biolink:BiologicalProcess	negative regulation of protein metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.		hp.json	down-regulation of protein metabolic process|down regulation of protein metabolic process|downregulation of cellular protein metabolic process|negative regulation of protein metabolism|inhibition of protein metabolic process|down regulation of cellular protein metabolic process|downregulation of protein metabolic process|inhibition of cellular protein metabolic process|negative regulation of cellular protein metabolism|negative regulation of cellular protein metabolic process|down-regulation of cellular protein metabolic process	http://purl.obolibrary.org/obo/GO_0051248		
GO:0051246	biolink:BiologicalProcess	regulation of protein metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.		hp.json	regulation of protein metabolism	http://purl.obolibrary.org/obo/GO_0051246		
GO:0004930	biolink:MolecularActivity	G protein-coupled receptor activity	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.	Reactome:R-HSA-114552|Reactome:R-HSA-167408|Wikipedia:GPCR|Reactome:R-HSA-114558	hp.json	orphan GPCR activity|G-protein coupled receptor activity|Epstein-Barr Virus-induced receptor activity|G protein linked receptor activity|orphan G-protein coupled receptor activity|G protein coupled receptor activity|G-protein coupled receptor activity, unknown ligand|Mas proto-oncogene receptor activity|G-protein linked receptor activity|orphan G protein coupled receptor activity|super conserved receptor expressed in brain receptor activity|EBV-induced receptor|receptor activity, G-protein coupled|RDC1 receptor activity|GPCR activity|ligand-dependent GPCR activity|SREB receptor	http://purl.obolibrary.org/obo/GO_0004930		goslim_chembl
GO:0051249	biolink:BiologicalProcess	regulation of lymphocyte activation	Any process that modulates the frequency, rate or extent of lymphocyte activation.		hp.json		http://purl.obolibrary.org/obo/GO_0051249		
CHEBI:28694	biolink:ChemicalSubstance	copper atom		Gmelin:16269|KEGG:C00070|CAS:7440-50-8|CAS:7440-50-8|WebElements:Cu	hp.json	Cu|Cu|cuivre|Copper|cuprum|Kupfer|copper|29Cu|cobre|copper	http://purl.obolibrary.org/obo/CHEBI_28694		3_STAR
UBERON:0008457	biolink:AnatomicalEntity	prezygapophysis of sacral vertebra	A prezygapophysis that is part of a sacral vertebra.	FMA:16215	hp.json	superior articular process of sacral segment|articular process of sacral segment|processus articularis superior (os sacrum)|superior articular process of sacrum|processus articularis superior ossis sacri|superior articular process of sacral vertebra	http://purl.obolibrary.org/obo/UBERON_0008457		
UBERON:0008459	biolink:AnatomicalEntity	prezygapophysis of cervical vertebra	A prezygapophysis that is part of a cervical vertebra.	FMA:23969	hp.json	superior articular process of cervical segment|superior articular process of cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0008459		
HP:0410299	biolink:PhenotypicFeature	Decreased specific antibody response to polysaccharide vaccine	A reduced ability to synthesize postvaccination antibodies against polysaccharides in vaccines, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410299		
HP:0410294	biolink:PhenotypicFeature	Decreased specific antibody response to protein vaccine	A reduced ability to synthesize postvaccination antibodies against proteins in vaccines, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410294		
HP:0410293	biolink:PhenotypicFeature	Absent isohemagglutinin level	Absent or undetectable level of isohemagglutinin. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person).		hp.json	Complete or near-complete absence of isohemagglutinins|Absent natural antibody to blood group agents	http://purl.obolibrary.org/obo/HP_0410293		
GO:0051240	biolink:BiologicalProcess	positive regulation of multicellular organismal process	Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.		hp.json	up regulation of multicellular organismal process|stimulation of multicellular organismal process|up-regulation of multicellular organismal process|activation of multicellular organismal process|upregulation of multicellular organismal process	http://purl.obolibrary.org/obo/GO_0051240		
HP:0410292	biolink:PhenotypicFeature	Abnormal isohemagglutinin level	An abnormal level of isohemagglutinin in the blood. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person).		hp.json	Abnormal natural antibody level to blood group antigens in blood (isohemagglutinin)|Abnormal level of natural antibody to blood group agents	http://purl.obolibrary.org/obo/HP_0410292		
NCBITaxon:38254	biolink:OrganismalEntity	Glaucocystophyceae		GC_ID:1	hp.json	Glaucophyta|algae|Glaucophyceae|glaucocystophytes	http://purl.obolibrary.org/obo/NCBITaxon_38254		
HP:0410291	biolink:PhenotypicFeature	Negativism	Opposing or not responding to instructions or external stimuli.		hp.json		http://purl.obolibrary.org/obo/HP_0410291		
HP:0410298	biolink:PhenotypicFeature	Partial absence of specific antibody response to hepatitis B vaccine	A reduced ability to synthesize postvaccination antibodies against a hepatitis B antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410298		
HP:0410297	biolink:PhenotypicFeature	Partial absence of specific antibody response to tetanus vaccine	A reduced ability to synthesize postvaccination antibodies against a tetanus antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410297		
GO:0051241	biolink:BiologicalProcess	negative regulation of multicellular organismal process	Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.		hp.json	downregulation of multicellular organismal process|down regulation of multicellular organismal process|inhibition of multicellular organismal process|down-regulation of multicellular organismal process	http://purl.obolibrary.org/obo/GO_0051241		
HP:0410296	biolink:PhenotypicFeature	Complete or near-complete absence of specific antibody response to hepatitis B vaccine	The inability to synthesize postvaccination antibodies against a hepatisis B antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410296		
UBERON:0008456	biolink:AnatomicalEntity	prezygapophysis of lumbar vertebra	A prezygapophysis that is part of a lumbar vertebra.	FMA:16126	hp.json	cranial articular process of lumbar vertebra|superior articular process of lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0008456		
HP:0410295	biolink:PhenotypicFeature	Complete or near-complete absence of specific antibody response to tetanus vaccine	The inability to synthesize postvaccination antibodies against a tetanus antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410295		
GO:0051258	biolink:BiologicalProcess	protein polymerization	The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein.		hp.json	protein polymer formation|protein polymer biosynthesis|protein polymer biosynthetic process	http://purl.obolibrary.org/obo/GO_0051258		goslim_pir
GO:1905432	biolink:BiologicalProcess	regulation of retrograde trans-synaptic signaling by neuropeptide	Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.		hp.json	regulation of neuropeptide-mediated retrograde trans-synaptic signaling	http://purl.obolibrary.org/obo/GO_1905432		
UBERON:0008447	biolink:AnatomicalEntity	intertarsal joint	Intertarsal articulations are the joints of the tarsus. The specific intertarsal articulations are: Talocalcaneal articulation Talocalcaneonavicular articulation Calcaneocuboid articulation Cuneonavicular articulation Cuboideonavicular articulation Intercuneiform articulation Cuneocuboid articulation.	UMLS:C1527245|FMA:44281|MA:0003112|MESH:D013640|EMAPA:37762|GAID:259|NCIT:C33735	hp.json	tarsal joints|articulationes intertarsale|articulationes intertarseae|intertarsal joint|intertarsal articulation|articulationes intertarsales|intertarsal|intermetatarsal joint|tarsal joint	http://purl.obolibrary.org/obo/UBERON_0008447		
GO:1905427	biolink:BiologicalProcess	intracellular signal transduction involved in positive regulation of cell growth	Any intracellular signal transduction that is involved in positive regulation of cell growth.		hp.json	intracellular protein kinase cascade involved in up regulation of cell growth|intracellular signaling chain involved in upregulation of cell growth|intracellular signaling cascade involved in up-regulation of cell growth|intracellular signal transduction involved in activation of cell growth|intracellular signaling chain involved in stimulation of cell growth|signal transduction via intracellular signaling cascade involved in stimulation of cell growth|intracellular signaling cascade involved in upregulation of cell growth|intracellular protein kinase cascade involved in positive regulation of cell growth|protein kinase cascade involved in stimulation of cell growth|intracellular protein kinase cascade involved in upregulation of cell growth|intracellular signaling cascade involved in activation of cell growth|intracellular protein kinase cascade involved in activation of cell growth|intracellular signal transduction involved in up-regulation of cell growth|intracellular signaling pathway involved in stimulation of cell growth|signal transmission via intracellular cascade involved in stimulation of cell growth|intracellular signaling cascade involved in up regulation of cell growth|protein kinase cascade involved in up-regulation of cell growth|signal transduction via intracellular signaling cascade involved in up-regulation of cell growth|intracellular signal transduction involved in upregulation of cell growth|intracellular signal transduction pathway involved in stimulation of cell growth|intracellular signaling cascade involved in positive regulation of cell growth|intracellular signal transduction pathway involved in upregulation of cell growth|intracellular signal transduction involved in up regulation of cell growth|intracellular signaling pathway involved in up-regulation of cell growth|intracellular signal transduction pathway involved in activation of cell growth|signal transmission via intracellular cascade involved in up-regulation of cell growth|protein kinase cascade involved in up regulation of cell growth|signal transmission via intracellular cascade involved in upregulation of cell growth|signal transduction via intracellular signaling cascade involved in up regulation of cell growth|intracellular signaling chain involved in up-regulation of cell growth|signal transmission via intracellular cascade involved in activation of cell growth|intracellular signal transduction pathway involved in up-regulation of cell growth|intracellular signaling pathway involved in up regulation of cell growth|protein kinase cascade involved in upregulation of cell growth|protein kinase cascade involved in positive regulation of cell growth|signal transmission via intracellular cascade involved in up regulation of cell growth|intracellular protein kinase cascade involved in stimulation of cell growth|signal transduction via intracellular signaling cascade involved in positive regulation of cell growth|protein kinase cascade involved in activation of cell growth|signal transmission via intracellular cascade involved in positive regulation of cell growth|intracellular signaling pathway involved in upregulation of cell growth|intracellular signaling chain involved in activation of cell growth|intracellular signaling chain involved in up regulation of cell growth|intracellular signal transduction pathway involved in up regulation of cell growth|intracellular signaling pathway involved in positive regulation of cell growth|intracellular signal transduction involved in stimulation of cell growth|intracellular signaling pathway involved in activation of cell growth|intracellular protein kinase cascade involved in up-regulation of cell growth|intracellular signal transduction pathway involved in positive regulation of cell growth|signal transduction via intracellular signaling cascade involved in upregulation of cell growth|intracellular signaling cascade involved in stimulation of cell growth|intracellular signaling chain involved in positive regulation of cell growth|signal transduction via intracellular signaling cascade involved in activation of cell growth	http://purl.obolibrary.org/obo/GO_1905427		
GO:0051250	biolink:BiologicalProcess	negative regulation of lymphocyte activation	Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation.		hp.json	down-regulation of lymphocyte activation|down regulation of lymphocyte activation|inhibition of lymphocyte activation|downregulation of lymphocyte activation	http://purl.obolibrary.org/obo/GO_0051250		
GO:0051251	biolink:BiologicalProcess	positive regulation of lymphocyte activation	Any process that activates or increases the frequency, rate or extent of lymphocyte activation.		hp.json	up regulation of lymphocyte activation|activation of lymphocyte activation|stimulation of lymphocyte activation|upregulation of lymphocyte activation|up-regulation of lymphocyte activation	http://purl.obolibrary.org/obo/GO_0051251		
GO:0051254	biolink:BiologicalProcess	positive regulation of RNA metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA.		hp.json	up-regulation of RNA metabolic process|up regulation of RNA metabolic process|activation of RNA metabolic process|positive regulation of RNA metabolism|stimulation of RNA metabolic process|upregulation of RNA metabolic process	http://purl.obolibrary.org/obo/GO_0051254		
GO:0051252	biolink:BiologicalProcess	regulation of RNA metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.		hp.json	regulation of RNA metabolism	http://purl.obolibrary.org/obo/GO_0051252		
GO:0051253	biolink:BiologicalProcess	negative regulation of RNA metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA.		hp.json	inhibition of RNA metabolic process|downregulation of RNA metabolic process|negative regulation of RNA metabolism|down-regulation of RNA metabolic process|down regulation of RNA metabolic process	http://purl.obolibrary.org/obo/GO_0051253		
GO:1905433	biolink:BiologicalProcess	negative regulation of retrograde trans-synaptic signaling by neuropeptide	Any process that stops, prevents or reduces the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.		hp.json	inhibition of neuropeptide-mediated retrograde trans-synaptic signaling|down-regulation of retrograde trans-synaptic signaling by neuropeptide|negative regulation of neuropeptide-mediated retrograde trans-synaptic signaling|down regulation of retrograde trans-synaptic signaling by neuropeptide|downregulation of retrograde trans-synaptic signaling by neuropeptide|inhibition of retrograde trans-synaptic signaling by neuropeptide	http://purl.obolibrary.org/obo/GO_1905433		
UBERON:0008435	biolink:AnatomicalEntity	vertebral arch of sacral segment	A neural arch that is part of a sacral vertebra.	FMA:32401	hp.json		http://purl.obolibrary.org/obo/UBERON_0008435		
GO:1905434	biolink:BiologicalProcess	positive regulation of retrograde trans-synaptic signaling by neuropeptide	Any process that activates or increases the frequency, rate or extent of retrograde trans-synaptic signaling by neuropeptide.		hp.json	up regulation of retrograde trans-synaptic signaling by neuropeptide|activation of retrograde trans-synaptic signaling by neuropeptide|positive regulation of neuropeptide-mediated retrograde trans-synaptic signaling|upregulation of retrograde trans-synaptic signaling by neuropeptide|up-regulation of retrograde trans-synaptic signaling by neuropeptide	http://purl.obolibrary.org/obo/GO_1905434		
UBERON:0008436	biolink:AnatomicalEntity	thoracic vertebral arch	A neural arch that is part of a thoracic vertebra.	FMA:9151	hp.json	arch of thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0008436		
GO:0051261	biolink:BiologicalProcess	protein depolymerization	The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein.		hp.json	protein polymer catabolism|protein polymer catabolic process|protein polymer degradation|protein polymer breakdown	http://purl.obolibrary.org/obo/GO_0051261		goslim_pir
UBERON:0008430	biolink:AnatomicalEntity	lumbar vertebral foramen	A vertebral foramen that is part of a lumbar vertebra.	FMA:24826	hp.json		http://purl.obolibrary.org/obo/UBERON_0008430		
UBERON:0008431	biolink:AnatomicalEntity	sacral foramen	A vertebral foramen that is part of a sacral vertebra.	FMA:31749	hp.json		http://purl.obolibrary.org/obo/UBERON_0008431		
UBERON:0008432	biolink:AnatomicalEntity	thoracic vertebral foramen	A vertebral foramen that is part of a thoracic vertebra.	FMA:9143	hp.json		http://purl.obolibrary.org/obo/UBERON_0008432		
UBERON:0008433	biolink:AnatomicalEntity	lumbar vertebral arch	A neural arch that is part of a lumbar vertebra.	FMA:16076	hp.json	arch of lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0008433		
UBERON:0008434	biolink:AnatomicalEntity	cervical vertebral arch	A neural arch that is part of a cervical vertebra.	FMA:23893	hp.json	arch of cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0008434		
GO:2000828	biolink:NamedThing	regulation of parathyroid hormone secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000828		
GO:2000829	biolink:NamedThing	negative regulation of parathyroid hormone secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000829		
GO:1905453	biolink:BiologicalProcess	regulation of myeloid progenitor cell differentiation	Any process that modulates the frequency, rate or extent of myeloid progenitor cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_1905453		
GO:1905454	biolink:BiologicalProcess	negative regulation of myeloid progenitor cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of myeloid progenitor cell differentiation.		hp.json	down-regulation of myeloid progenitor cell differentiation|down regulation of myeloid progenitor cell differentiation|downregulation of myeloid progenitor cell differentiation|inhibition of myeloid progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_1905454		
GO:2000826	biolink:BiologicalProcess	regulation of heart morphogenesis	Any process that modulates the frequency, rate or extent of heart morphogenesis.		hp.json	regulation of cardiac morphogenesis	http://purl.obolibrary.org/obo/GO_2000826		
GO:0051272	biolink:BiologicalProcess	positive regulation of cellular component movement	Any process that activates or increases the frequency, rate or extent of the movement of a cellular component.		hp.json	positive regulation of cellular component motion	http://purl.obolibrary.org/obo/GO_0051272		
GO:0051270	biolink:BiologicalProcess	regulation of cellular component movement	Any process that modulates the frequency, rate or extent of the movement of a cellular component.		hp.json	regulation of cellular component motion|regulation of cell movement	http://purl.obolibrary.org/obo/GO_0051270		
CHEBI:16651	biolink:ChemicalSubstance	(S)-lactate	An optically active form of lactate having (S)-configuration.	Reaxys:4655977|Beilstein:4655977|KEGG:C00186|MetaCyc:L-LACTATE|Gmelin:324523|UM-BBD_compID:c0152	hp.json	L(+)-lactate|(+)-lactate|L-(+)-lactate|L-lactate|(S)-lactate|(2S)-2-hydroxypropanoate	http://purl.obolibrary.org/obo/CHEBI_16651		3_STAR
GO:0051271	biolink:BiologicalProcess	negative regulation of cellular component movement	Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component.		hp.json	negative regulation of cellular component motion	http://purl.obolibrary.org/obo/GO_0051271		
GO:0051276	biolink:BiologicalProcess	chromosome organization	A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.		hp.json	DNA packaging|nuclear genome maintenance|maintenance of genome integrity|chromosome organization and biogenesis|DNA condensation|chromosome organisation	http://purl.obolibrary.org/obo/GO_0051276		goslim_pir|goslim_drosophila|goslim_chembl
CHEBI:28659	biolink:ChemicalSubstance	phosphorus atom		WebElements:P|CAS:7723-14-0|CAS:7723-14-0|Gmelin:16235|KEGG:C06262	hp.json	phosphore|15P|Phosphorus|P|Phosphor|phosphorus|phosphorus|P|fosforo	http://purl.obolibrary.org/obo/CHEBI_28659		3_STAR
GO:2000830	biolink:NamedThing	positive regulation of parathyroid hormone secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000830		
GO:2000831	biolink:BiologicalProcess	regulation of steroid hormone secretion	Any process that modulates the frequency, rate or extent of steroid hormone secretion.		hp.json		http://purl.obolibrary.org/obo/GO_2000831		
GO:1905460	biolink:BiologicalProcess	negative regulation of vascular associated smooth muscle cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.		hp.json	inhibition of vascular associated smooth muscle cell apoptosis|inhibition of vascular associated smooth muscle cell apoptotic process|down regulation of vascular smooth muscle cell apoptotic process|down-regulation of vascular associated smooth muscle cell apoptotic process|down regulation of VSMC apoptosis|downregulation of VSMC apoptotic process|inhibition of vascular smooth muscle cell apoptotic process|downregulation of vascular smooth muscle cell apoptotic process|inhibition of vascular smooth muscle cell apoptosis|down-regulation of VSMC apoptosis|downregulation of vascular associated smooth muscle cell apoptosis|negative regulation of VSMC apoptosis|down regulation of VSMC apoptotic process|negative regulation of vascular smooth muscle cell apoptosis|down-regulation of vascular smooth muscle cell apoptosis|inhibition of VSMC apoptotic process|inhibition of VSMC apoptosis|down regulation of vascular associated smooth muscle cell apoptosis|down-regulation of VSMC apoptotic process|downregulation of vascular associated smooth muscle cell apoptotic process|negative regulation of VSMC apoptotic process|down regulation of vascular smooth muscle cell apoptosis|down-regulation of vascular associated smooth muscle cell apoptosis|negative regulation of vascular associated smooth muscle cell apoptosis|negative regulation of vascular smooth muscle cell apoptotic process|down-regulation of vascular smooth muscle cell apoptotic process|downregulation of VSMC apoptosis|down regulation of vascular associated smooth muscle cell apoptotic process|downregulation of vascular smooth muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_1905460		
GO:2000832	biolink:BiologicalProcess	negative regulation of steroid hormone secretion	Any process that stops, prevents or reduces the frequency, rate or extent of steroid hormone secretion.		hp.json		http://purl.obolibrary.org/obo/GO_2000832		
GO:1905461	biolink:BiologicalProcess	positive regulation of vascular associated smooth muscle cell apoptotic process	Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.		hp.json	positive regulation of vascular associated smooth muscle cell apoptosis|up regulation of VSMC apoptotic process|upregulation of vascular associated smooth muscle cell apoptotic process|up regulation of vascular smooth muscle cell apoptosis|up regulation of vascular associated smooth muscle cell apoptosis|activation of VSMC apoptotic process|up-regulation of VSMC apoptotic process|activation of VSMC apoptosis|positive regulation of vascular smooth muscle cell apoptosis|upregulation of VSMC apoptosis|up-regulation of vascular associated smooth muscle cell apoptosis|up-regulation of vascular smooth muscle cell apoptotic process|up regulation of vascular smooth muscle cell apoptotic process|up regulation of vascular associated smooth muscle cell apoptotic process|upregulation of vascular smooth muscle cell apoptosis|activation of vascular smooth muscle cell apoptotic process|activation of vascular smooth muscle cell apoptosis|positive regulation of VSMC apoptosis|positive regulation of vascular smooth muscle cell apoptotic process|up-regulation of vascular associated smooth muscle cell apoptotic process|upregulation of VSMC apoptotic process|up regulation of VSMC apoptosis|activation of vascular associated smooth muscle cell apoptosis|activation of vascular associated smooth muscle cell apoptotic process|upregulation of vascular associated smooth muscle cell apoptosis|upregulation of vascular smooth muscle cell apoptotic process|up-regulation of VSMC apoptosis|up-regulation of vascular smooth muscle cell apoptosis|positive regulation of VSMC apoptotic process	http://purl.obolibrary.org/obo/GO_1905461		
GO:2000833	biolink:BiologicalProcess	positive regulation of steroid hormone secretion	Any process that activates or increases the frequency, rate or extent of steroid hormone secretion.		hp.json		http://purl.obolibrary.org/obo/GO_2000833		
GO:2000834	biolink:BiologicalProcess	regulation of androgen secretion	Any process that modulates the frequency, rate or extent of androgen secretion.		hp.json		http://purl.obolibrary.org/obo/GO_2000834		
GO:2000835	biolink:BiologicalProcess	negative regulation of androgen secretion	Any process that stops, prevents or reduces the frequency, rate or extent of androgen secretion.		hp.json		http://purl.obolibrary.org/obo/GO_2000835		
GO:2000836	biolink:BiologicalProcess	positive regulation of androgen secretion	Any process that activates or increases the frequency, rate or extent of androgen secretion.		hp.json		http://purl.obolibrary.org/obo/GO_2000836		
GO:1905455	biolink:BiologicalProcess	positive regulation of myeloid progenitor cell differentiation	Any process that activates or increases the frequency, rate or extent of myeloid progenitor cell differentiation.		hp.json	upregulation of myeloid progenitor cell differentiation|up-regulation of myeloid progenitor cell differentiation|up regulation of myeloid progenitor cell differentiation|activation of myeloid progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_1905455		
GO:1905456	biolink:BiologicalProcess	regulation of lymphoid progenitor cell differentiation	Any process that modulates the frequency, rate or extent of lymphoid progenitor cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_1905456		
GO:1905457	biolink:BiologicalProcess	negative regulation of lymphoid progenitor cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of lymphoid progenitor cell differentiation.		hp.json	downregulation of lymphoid progenitor cell differentiation|down regulation of lymphoid progenitor cell differentiation|inhibition of lymphoid progenitor cell differentiation|down-regulation of lymphoid progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_1905457		
GO:1905458	biolink:BiologicalProcess	positive regulation of lymphoid progenitor cell differentiation	Any process that activates or increases the frequency, rate or extent of lymphoid progenitor cell differentiation.		hp.json	up regulation of lymphoid progenitor cell differentiation|up-regulation of lymphoid progenitor cell differentiation|activation of lymphoid progenitor cell differentiation|upregulation of lymphoid progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_1905458		
GO:1905459	biolink:BiologicalProcess	regulation of vascular associated smooth muscle cell apoptotic process	Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.		hp.json	regulation of vascular smooth muscle cell apoptosis|regulation of VSMC apoptosis|regulation of vascular smooth muscle cell apoptotic process|regulation of VSMC apoptotic process|regulation of vascular associated smooth muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_1905459		
CHEBI:16646	biolink:ChemicalSubstance	carbohydrate	Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates.	Wikipedia:Carbohydrate	hp.json	glucido|a carbohydrate|saccharide|saccharidum|carbohidrato|glucides|hydrates de carbone|carbohidratos|glucide|saccharides|carbohydrate|carbohydrates|Kohlenhydrat|glucidos|Kohlenhydrate	http://purl.obolibrary.org/obo/CHEBI_16646		3_STAR
GO:2000846	biolink:NamedThing	regulation of corticosteroid hormone secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000846		
GO:1905475	biolink:BiologicalProcess	regulation of protein localization to membrane	Any process that modulates the frequency, rate or extent of protein localization to membrane.		hp.json	regulation of protein localisation in membrane|regulation of protein localization in membrane	http://purl.obolibrary.org/obo/GO_1905475		
GO:2000847	biolink:NamedThing	negative regulation of corticosteroid hormone secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000847		
GO:1905476	biolink:BiologicalProcess	negative regulation of protein localization to membrane	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to membrane.		hp.json	inhibition of protein localization to membrane|down-regulation of protein localization to membrane|down regulation of protein localisation in membrane|inhibition of protein localisation in membrane|negative regulation of protein localisation in membrane|down-regulation of protein localisation in membrane|downregulation of protein localization in membrane|down regulation of protein localization in membrane|inhibition of protein localization in membrane|downregulation of protein localization to membrane|down-regulation of protein localization in membrane|negative regulation of protein localization in membrane|downregulation of protein localisation in membrane|down regulation of protein localization to membrane	http://purl.obolibrary.org/obo/GO_1905476		
GO:2000848	biolink:NamedThing	positive regulation of corticosteroid hormone secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000848		
CHEBI:16670	biolink:ChemicalSubstance	peptide	Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.	KEGG:C00012	hp.json	peptidos|peptides|Peptid|Peptide|peptido	http://purl.obolibrary.org/obo/CHEBI_16670		3_STAR
CHEBI:41609	biolink:ChemicalSubstance	carbonate		PDBeChem:CO3|Gmelin:1559|Beilstein:3600898|CAS:3812-32-6	hp.json	CO3(2-)|trioxidocarbonate(2-)|carbonate|[CO3](2-)|Karbonat|CARBONATE ION	http://purl.obolibrary.org/obo/CHEBI_41609		3_STAR
GO:1905483	biolink:BiologicalProcess	regulation of motor neuron migration	Any process that modulates the frequency, rate or extent of motor neuron migration.		hp.json		http://purl.obolibrary.org/obo/GO_1905483		
GO:2000855	biolink:NamedThing	regulation of mineralocorticoid secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000855		
GO:1905484	biolink:BiologicalProcess	negative regulation of motor neuron migration	Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron migration.		hp.json	inhibition of motor neuron migration|down-regulation of motor neuron migration|downregulation of motor neuron migration|down regulation of motor neuron migration	http://purl.obolibrary.org/obo/GO_1905484		
GO:2000856	biolink:NamedThing	negative regulation of mineralocorticoid secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000856		
GO:2000857	biolink:NamedThing	positive regulation of mineralocorticoid secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000857		
GO:1905485	biolink:BiologicalProcess	positive regulation of motor neuron migration	Any process that activates or increases the frequency, rate or extent of motor neuron migration.		hp.json	upregulation of motor neuron migration|up regulation of motor neuron migration|activation of motor neuron migration|up-regulation of motor neuron migration	http://purl.obolibrary.org/obo/GO_1905485		
GO:2000858	biolink:NamedThing	regulation of aldosterone secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000858		
GO:2000859	biolink:NamedThing	negative regulation of aldosterone secretion			hp.json		http://purl.obolibrary.org/obo/GO_2000859		
GO:1905477	biolink:BiologicalProcess	positive regulation of protein localization to membrane	Any process that activates or increases the frequency, rate or extent of protein localization to membrane.		hp.json	positive regulation of protein localization in membrane|up regulation of protein localization in membrane|upregulation of protein localization to membrane|upregulation of protein localisation in membrane|up-regulation of protein localization in membrane|activation of protein localization in membrane|up regulation of protein localization to membrane|positive regulation of protein localisation in membrane|up-regulation of protein localization to membrane|up regulation of protein localisation in membrane|activation of protein localization to membrane|upregulation of protein localization in membrane|activation of protein localisation in membrane|up-regulation of protein localisation in membrane	http://purl.obolibrary.org/obo/GO_1905477		
NCBITaxon:2	biolink:OrganismalEntity	Bacteria		PMID:10425795|PMID:8123559|PMID:11411719|GC_ID:11|PMID:11540071|PMID:11321083|PMID:9336922|PMID:9103655|PMID:11760965|PMID:10939677|PMID:8186100|PMID:8590690|PMID:12054223|PMID:7520741|PMID:10843050|PMID:2112744|PMID:11542017|PMID:11211268|PMID:10939673|PMID:10939651|PMID:11321113|PMID:10490293|PMID:10425797|PMID:10425796|PMID:11542087|PMID:270744	hp.json	Prokaryotae|Prokaryota|prokaryotes|bacteria|Procaryotae|eubacteria|Monera|prokaryote	http://purl.obolibrary.org/obo/NCBITaxon_2		
NCBITaxon:1	biolink:OrganismalEntity	root		GC_ID:1	hp.json	all	http://purl.obolibrary.org/obo/NCBITaxon_1		
GO:0004888	biolink:MolecularActivity	transmembrane signaling receptor activity	Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.	Reactome:R-HSA-193672	hp.json	transmembrane receptor activity|transmembrane signalling receptor activity	http://purl.obolibrary.org/obo/GO_0004888		
GO:0002225	biolink:BiologicalProcess	positive regulation of antimicrobial peptide production	Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.		hp.json	up-regulation of antimicrobial peptide production|activation of antimicrobial peptide production|antimicrobial peptide induction|upregulation of antimicrobial peptide production|up regulation of antimicrobial peptide production|stimulation of antimicrobial peptide production	http://purl.obolibrary.org/obo/GO_0002225		
GO:0016866	biolink:MolecularActivity	intramolecular transferase activity	Catalysis of the transfer of a functional group from one position to another within a single molecule.	EC:5.4.-.-	hp.json	mutase activity|intramolecular transferase activity, transferring other groups	http://purl.obolibrary.org/obo/GO_0016866		
GO:0016868	biolink:MolecularActivity	intramolecular transferase activity, phosphotransferases	Catalysis of the transfer of a phosphate group from one position to another within a single molecule.	EC:5.4.2.-	hp.json	phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers|phosphomutase activity	http://purl.obolibrary.org/obo/GO_0016868		
GO:0002232	biolink:BiologicalProcess	leukocyte chemotaxis involved in inflammatory response	The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.		hp.json	immune cell chemotaxis during inflammatory response|leucocyte chemotaxis during inflammatory response|leukocyte chemotaxis during inflammatory response	http://purl.obolibrary.org/obo/GO_0002232		
GO:0002233	biolink:BiologicalProcess	leukocyte chemotaxis involved in immune response	The movement of an immune cell in response to an external stimulus a part of an immune response.		hp.json	immune cell chemotaxis during immune response|leucocyte chemotaxis during immune response	http://purl.obolibrary.org/obo/GO_0002233		
GO:0016874	biolink:MolecularActivity	ligase activity	Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.	EC:6.-.-.-	hp.json	synthetase activity	http://purl.obolibrary.org/obo/GO_0016874		goslim_pir|goslim_drosophila|goslim_chembl|goslim_metagenomics|goslim_mouse|goslim_yeast|goslim_generic|goslim_candida|prokaryote_subset
GO:0002215	biolink:BiologicalProcess	defense response to nematode	A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.		hp.json	physiological defense response to nematode	http://purl.obolibrary.org/obo/GO_0002215		
GO:0002213	biolink:BiologicalProcess	defense response to insect	A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.		hp.json	physiological defense response to insect	http://purl.obolibrary.org/obo/GO_0002213		
CL:0011115	biolink:Cell	precursor cell	A cell that, by division or terminal differentiation, can give rise to other cell types.		hp.json		http://purl.obolibrary.org/obo/CL_0011115		
GO:0016853	biolink:MolecularActivity	isomerase activity	Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.	EC:5.-.-.-|Reactome:R-HSA-6787623	hp.json	other isomerase activity	http://purl.obolibrary.org/obo/GO_0016853		prokaryote_subset|goslim_pir|goslim_drosophila|goslim_chembl|goslim_metagenomics|goslim_yeast|goslim_candida|goslim_generic
CL:0011101	biolink:Cell	chorionic trophoblast cell	Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.		hp.json		http://purl.obolibrary.org/obo/CL_0011101		
GO:0016829	biolink:MolecularActivity	lyase activity	Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.	Reactome:R-HSA-6782895|Reactome:R-HSA-5696408|EC:4.-.-.-	hp.json	other lyase activity	http://purl.obolibrary.org/obo/GO_0016829		goslim_chembl|goslim_metagenomics|goslim_yeast|goslim_generic|goslim_candida|prokaryote_subset|goslim_pir|goslim_drosophila
CL:0011108	biolink:Cell	colon epithelial cell	Epithelial cell that is part of the colon epithelium.		hp.json	colonic epithelial cell	http://purl.obolibrary.org/obo/CL_0011108		
GO:0016835	biolink:MolecularActivity	carbon-oxygen lyase activity	Catalysis of the breakage of a carbon-oxygen bond.	EC:4.2.-.-	hp.json	other carbon-oxygen lyase activity	http://purl.obolibrary.org/obo/GO_0016835		
GO:0016836	biolink:MolecularActivity	hydro-lyase activity	Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.	EC:4.2.1.-|Reactome:R-HSA-9014627	hp.json		http://purl.obolibrary.org/obo/GO_0016836		
GO:0051216	biolink:BiologicalProcess	cartilage development	The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.	Wikipedia:Chondrogenesis	hp.json	chondrogenesis|cartilage organ development|cartilage biogenesis|cartilage element development|cartilage biosynthesis|cartilage formation	http://purl.obolibrary.org/obo/GO_0051216		
UBERON:0008523	biolink:AnatomicalEntity	infrahyoid muscle	The infrahyoid muscles are a group of four pairs of muscles in the anterior part of the neck. (The term infrahyoid refers to the region below to the hyoid bone in the neck. ) Collectively, they are referred to as the strap muscles, because the muscles are long and flat much like a strap.	FMA:13338	hp.json	infrahyoidala|infrahyoid|infrahyoid muscle|musculi infrahyoidei|strap muscles|musculus infrahyoideus|strap muscle	http://purl.obolibrary.org/obo/UBERON_0008523		
UBERON:0008529	biolink:AnatomicalEntity	piriformis muscle	The piriformis is a muscle in the gluteal region that originates from the anterior (front) part of the sacrum, the part of the spine in the gluteal region, and from the superior margin of the greater sciatic notch (as well as the sacroiliac joint capsule and the sacrotuberous ligament). It exits the pelvis through the greater sciatic foramen to insert on the greater trochanter of the femur. Its tendon often joins with the tendons of the superior gemellus, inferior gemellus, and obturator internus muscles prior to insertion[WP,modified].	EMAPA:36239|FMA:19082	hp.json	piriformis muscle|musculus piriformis|musculus piriformis|piriform muscle|m.piriformis|piriformis	http://purl.obolibrary.org/obo/UBERON_0008529		
UBERON:0008522	biolink:AnatomicalEntity	nasal muscle	Any muscle organ that is part of an nose.	FMA:73758|NCIT:C33158|UMLS:C0224219	hp.json	muscle of nose	http://purl.obolibrary.org/obo/UBERON_0008522		
GO:0051223	biolink:BiologicalProcess	regulation of protein transport	Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0051223		
GO:0051224	biolink:BiologicalProcess	negative regulation of protein transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	inhibition of protein transport|downregulation of protein transport|down-regulation of protein transport|down regulation of protein transport	http://purl.obolibrary.org/obo/GO_0051224		
GO:0051222	biolink:BiologicalProcess	positive regulation of protein transport	Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	up-regulation of protein transport|up regulation of protein transport|activation of protein transport|stimulation of protein transport|upregulation of protein transport	http://purl.obolibrary.org/obo/GO_0051222		
HP:0011373	biolink:PhenotypicFeature	Incomplete partition of the cochlea	Incomplete formation of the cochlear partition. The scala vestibuli and scala tympani separated by the cochlear partition, except in the apical turn where the two scalae are in continuity via the helicotrema.	UMLS:C4023392	hp.json		http://purl.obolibrary.org/obo/HP_0011373		
HP:0011374	biolink:PhenotypicFeature	Incomplete partition of the cochlea type I	Incomplete partition I is also known as cystic cochleovestibular malformation, where the cochlea has no bony modiolus, resulting in an empty cystic cochlea. This is accompanied by a dilated cystic vestibule with developmental arrest at the fifth week of gestation.	UMLS:C4023391	hp.json		http://purl.obolibrary.org/obo/HP_0011374		
HP:0011375	biolink:PhenotypicFeature	Cochlear aplasia	Absence of the cochlea, a spiral shaped cavity in the inner ear, owing to a developmental defect.	UMLS:C4023390	hp.json	Absent cochlea	http://purl.obolibrary.org/obo/HP_0011375		
HP:0011376	biolink:PhenotypicFeature	Morphological abnormality of the vestibule of the inner ear	A morphological abnormality of the vestibule, the central part of the osseous labyrinth that is situated medial to the tympanic cavity, behind the cochlea, and in front of the semicircular canals.	UMLS:C0542259	hp.json	Vestibular abnormality	http://purl.obolibrary.org/obo/HP_0011376		
HP:0011377	biolink:PhenotypicFeature	Aplasia of the vestibule	Complete absence of the vestibule of the inner ear.	UMLS:C4023389	hp.json	Absent vestibule	http://purl.obolibrary.org/obo/HP_0011377		
HP:0011378	biolink:PhenotypicFeature	Hypoplasia of the vestibule of the inner ear	Underdevelopment of the vestibule of the inner ear.	UMLS:C4023388	hp.json		http://purl.obolibrary.org/obo/HP_0011378		
HP:0011379	biolink:PhenotypicFeature	Dilated vestibule of the inner ear	Dilatation of the vestibule of the inner ear.	UMLS:C4023387	hp.json		http://purl.obolibrary.org/obo/HP_0011379		
HP:0011370	biolink:PhenotypicFeature	Recurrent cutaneous fungal infections	Increased susceptibility to cutaneous fungal infections, as manifested by recurrent episodes of cutaneous fungal infections.	UMLS:C4023394	hp.json		http://purl.obolibrary.org/obo/HP_0011370		
HP:0011371	biolink:PhenotypicFeature	Recurrent viral skin infections	Increased susceptibility to viral skin infections, as manifested by recurrent episodes of viral skin infections.	UMLS:C4023393	hp.json	Recurrent viral skin infections	http://purl.obolibrary.org/obo/HP_0011371		
HP:0011372	biolink:PhenotypicFeature	Aplasia of the inner ear	Absence of the inner ear due to a developmental defect.	UMLS:C0266604|SNOMEDCT_US:71973003	hp.json	Michel deformity|Aplasia of the labyrinth|Absent inner ear|Labyrinthine aplasia	http://purl.obolibrary.org/obo/HP_0011372		
HP:0011362	biolink:PhenotypicFeature	Abnormal hair quantity	An abnormal amount of hair.	UMLS:C4023401|UMLS:C4023397	hp.json	Abnormality of hair density|Abnormal hair quantity	http://purl.obolibrary.org/obo/HP_0011362		
HP:0011363	biolink:PhenotypicFeature	Abnormality of hair growth rate	Hair whose growth rate deviates from the norm.	UMLS:C4023396	hp.json	Abnormality of pace of hair growth|Abnormality of hair growth rate|Abnormality of speed of hair growth	http://purl.obolibrary.org/obo/HP_0011363		
HP:0011364	biolink:PhenotypicFeature	White hair	Hypopigmented hair that appears white.	SNOMEDCT_US:297993006|UMLS:C0239804	hp.json	White hair	http://purl.obolibrary.org/obo/HP_0011364		
HP:0011365	biolink:PhenotypicFeature	Patchy hypopigmentation of hair	Reduced pigmentation of hair in patches.	UMLS:C4023395	hp.json		http://purl.obolibrary.org/obo/HP_0011365		
HP:0011367	biolink:PhenotypicFeature	Yellow nails	Yellowish discoloration of the nails.	SNOMEDCT_US:45342007|UMLS:C1768507	hp.json	Yellow nails	http://purl.obolibrary.org/obo/HP_0011367		
HP:0011368	biolink:PhenotypicFeature	Epidermal thickening	Thickening of the epidermal layer of the skin.	UMLS:C4020752|UMLS:C0494876	hp.json	Abnormality of keratinization	http://purl.obolibrary.org/obo/HP_0011368		
HP:0011369	biolink:PhenotypicFeature	Mongolian blue spot	Congenital deep dermal melanosis in the sacral area.	SNOMEDCT_US:40467008|MSH:D049328|UMLS:C0265985	hp.json		http://purl.obolibrary.org/obo/HP_0011369		
HP:0011360	biolink:PhenotypicFeature	Acquired abnormal hair pattern	An abnormality of the distribution of hair growth that is acquired during the course of life.	UMLS:C4023399	hp.json	Acquired abnormal hair pattern	http://purl.obolibrary.org/obo/HP_0011360		
HP:0011361	biolink:PhenotypicFeature	Congenital abnormal hair pattern	A congenital abnormality of the distribution of hair growth.	UMLS:C4023398	hp.json	Abnormal hair pattern since birth	http://purl.obolibrary.org/obo/HP_0011361		
HP:0011351	biolink:PhenotypicFeature	Moderate receptive language delay	A moderate delay in the acquisition of the ability to understand the speech of others.	UMLS:C3532946|SNOMEDCT_US:89381000119107	hp.json		http://purl.obolibrary.org/obo/HP_0011351		
HP:0011352	biolink:PhenotypicFeature	Severe receptive language delay	A severe delay in the acquisition of the ability to understand the speech of others.	UMLS:C3532947|SNOMEDCT_US:89391000119105	hp.json		http://purl.obolibrary.org/obo/HP_0011352		
HP:0011353	biolink:PhenotypicFeature	Arterial intimal fibrosis	Formation of excess fibrous connective tissue in the tunica intima (innermost layer) of arteries.	UMLS:C4020753|UMLS:C4023403	hp.json	Intimal fibrosis	http://purl.obolibrary.org/obo/HP_0011353		
HP:0011354	biolink:PhenotypicFeature	Generalized abnormality of skin	An abnormality of the skin that is not localized to any one particular region.	UMLS:C4021157	hp.json	Generalised abnormality of skin|Generalized abnormality of skin	http://purl.obolibrary.org/obo/HP_0011354		
HP:0011355	biolink:PhenotypicFeature	Localized skin lesion	A lesion of the skin that is located in a specific region rather than being generalized.	UMLS:C0850826	hp.json	Localised skin lesion|Localized skin lesion	http://purl.obolibrary.org/obo/HP_0011355		
HP:0011356	biolink:PhenotypicFeature	Regional abnormality of skin	An abnormality of the skin that is restricted to a particular body region.	UMLS:C4023402	hp.json		http://purl.obolibrary.org/obo/HP_0011356		
HP:0011357	biolink:PhenotypicFeature	obsolete Abnormality of hair density			hp.json		http://purl.obolibrary.org/obo/HP_0011357		
HP:0011358	biolink:PhenotypicFeature	Generalized hypopigmentation of hair	Reduced pigmentation of hair diffusely.	UMLS:C4023400	hp.json	Generalised hypopigmentation of hair	http://purl.obolibrary.org/obo/HP_0011358		
GO:0002283	biolink:BiologicalProcess	neutrophil activation involved in immune response	The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.		hp.json	neutrophil activation during immune response	http://purl.obolibrary.org/obo/GO_0002283		
GO:0002284	biolink:BiologicalProcess	myeloid dendritic cell differentiation involved in immune response	The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.		hp.json	myeloid dendritic cell differentiation during immune response	http://purl.obolibrary.org/obo/GO_0002284		
GO:0002285	biolink:BiologicalProcess	lymphocyte activation involved in immune response	A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.		hp.json	lymphocyte activation during immune response	http://purl.obolibrary.org/obo/GO_0002285		
GO:0002286	biolink:BiologicalProcess	T cell activation involved in immune response	The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.		hp.json	T-cell activation during immune response|T lymphocyte activation during immune response|T-lymphocyte activation during immune response|T cell activation during immune response	http://purl.obolibrary.org/obo/GO_0002286		
OBO:chebi#is_substituent_group_from	biolink:NamedThing	is substituent group from			hp.json		http://purl.obolibrary.org/obo/chebi#is_substituent_group_from		
GO:0002280	biolink:BiologicalProcess	monocyte activation involved in immune response	The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.		hp.json	monocyte activation during immune response	http://purl.obolibrary.org/obo/GO_0002280		
GO:0002281	biolink:BiologicalProcess	macrophage activation involved in immune response	A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.		hp.json	macrophage polarization involved in immune response|macrophage activation during immune response	http://purl.obolibrary.org/obo/GO_0002281		
HP:0011350	biolink:PhenotypicFeature	Mild receptive language delay	A mild delay in the acquisition of the ability to understand the speech of others.	UMLS:C3532948|SNOMEDCT_US:89501000119108	hp.json		http://purl.obolibrary.org/obo/HP_0011350		
HP:0011359	biolink:PhenotypicFeature	Dry hair	Hair that lacks the lustre (shine or gleam) of normal hair.	UMLS:C0277960|SNOMEDCT_US:79395009	hp.json	Dry hair	http://purl.obolibrary.org/obo/HP_0011359		
HP:0011340	biolink:PhenotypicFeature	Incomplete cleft of the upper lip	A subtle unilateral cleft of the upper lip, which may appear as a small indentation.	UMLS:C4021158	hp.json	Incomplete cheiloschisis|Notched cleft of the upper lip|Incomplete cleft of the upper lip|Partial cleft of the upper lip|Forme fruste unilateral cleft lip	http://purl.obolibrary.org/obo/HP_0011340		
HP:0011341	biolink:PhenotypicFeature	Long upper lip	Increased width of the upper lip.	UMLS:C3151495	hp.json	Long upper lip|Increased vertical length of upper lip|Elongation of upper lip|Increased height of upper lip	http://purl.obolibrary.org/obo/HP_0011341		
HP:0011342	biolink:PhenotypicFeature	Mild global developmental delay	A mild delay in the achievement of motor or mental milestones in the domains of development of a child.	UMLS:C4012968|UMLS:C2229182	hp.json	Global developmental delay, mild|Psychomotor retardation, mild	http://purl.obolibrary.org/obo/HP_0011342		
HP:0011343	biolink:PhenotypicFeature	Moderate global developmental delay	A moderate delay in the achievement of motor or mental milestones in the domains of development of a child.	UMLS:C2237142	hp.json	Psychomotor retardation, moderate|Global developmental delay, moderate	http://purl.obolibrary.org/obo/HP_0011343		
HP:0011344	biolink:PhenotypicFeature	Severe global developmental delay	A severe delay in the achievement of motor or mental milestones in the domains of development of a child.	UMLS:C1854919|UMLS:C1837397	hp.json	Global developmental delay, severe|Severe psychomotor retardation	http://purl.obolibrary.org/obo/HP_0011344		
HP:0011345	biolink:PhenotypicFeature	Moderate expressive language delay	A moderate delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.	UMLS:C3532933|SNOMEDCT_US:62211000119103	hp.json		http://purl.obolibrary.org/obo/HP_0011345		
HP:0011346	biolink:PhenotypicFeature	Mild expressive language delay	A mild delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.	SNOMEDCT_US:62231000119108|UMLS:C3532934	hp.json		http://purl.obolibrary.org/obo/HP_0011346		
HP:0011347	biolink:PhenotypicFeature	Abnormality of ocular abduction	An abnormality involving the movement of the eye outwards.	UMLS:C4023405	hp.json		http://purl.obolibrary.org/obo/HP_0011347		
GO:0002292	biolink:BiologicalProcess	T cell differentiation involved in immune response	The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.		hp.json	T lymphocyte differentiation during immune response|T cell differentiation during immune response|T-cell differentiation during immune response|T cell development involved in immune response|T-lymphocyte differentiation during immune response	http://purl.obolibrary.org/obo/GO_0002292		
HP:0011348	biolink:PhenotypicFeature	Abnormal sixth cranial nerve morphology	Any structural abnormality of the abducens nerve.	UMLS:C4023404	hp.json	Abnormality of the sixth cranial nerve|Abnormal abducens nerve morphology	http://purl.obolibrary.org/obo/HP_0011348		
HP:0011349	biolink:PhenotypicFeature	obsolete Abducens palsy			hp.json		http://purl.obolibrary.org/obo/HP_0011349		
GO:0002269	biolink:BiologicalProcess	leukocyte activation involved in inflammatory response	A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.		hp.json	immune cell activation during inflammatory response|leukocyte activation during inflammatory response	http://purl.obolibrary.org/obo/GO_0002269		
GO:0002262	biolink:BiologicalProcess	myeloid cell homeostasis	The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0002262		
GO:0002263	biolink:BiologicalProcess	cell activation involved in immune response	A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.		hp.json	cell activation during immune response	http://purl.obolibrary.org/obo/GO_0002263		
GO:0002264	biolink:BiologicalProcess	endothelial cell activation involved in immune response	A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.		hp.json	endothelial cell activation during immune response	http://purl.obolibrary.org/obo/GO_0002264		
GO:0002260	biolink:BiologicalProcess	lymphocyte homeostasis	The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0002260		
GO:0002277	biolink:BiologicalProcess	myeloid dendritic cell activation involved in immune response	The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.		hp.json	myeloid dendritic cell activation during immune response	http://purl.obolibrary.org/obo/GO_0002277		
GO:0002274	biolink:BiologicalProcess	myeloid leukocyte activation	A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.		hp.json	myeloid leucocyte activation	http://purl.obolibrary.org/obo/GO_0002274		
GO:0002275	biolink:BiologicalProcess	myeloid cell activation involved in immune response	A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.		hp.json	myeloid cell activation during immune response	http://purl.obolibrary.org/obo/GO_0002275		
HP:0011395	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the cochlea	Absence or underdevelopment of the cochlea, a spiral shaped cavity in the inner ear, owing to a developmental defect.	UMLS:C4023378	hp.json	Absent/small cochlea|Absent/underdeveloped cochlea	http://purl.obolibrary.org/obo/HP_0011395		
HP:0011396	biolink:PhenotypicFeature	Abnormality of the cochlear nerve		UMLS:C4023377	hp.json		http://purl.obolibrary.org/obo/HP_0011396		
HP:0011397	biolink:PhenotypicFeature	Abnormality of the dorsal column of the spinal cord	An abnormality of the dorsal columns, i.e., of the dorsal portion of the gray substance of the spinal cord. The dorsal column consists of the fasciculus gracilis and fasciculus cuneatus and itself is part of the dorsal funiculus.	UMLS:C4023376	hp.json		http://purl.obolibrary.org/obo/HP_0011397		
HP:0011398	biolink:PhenotypicFeature	obsolete Central hypotonia			hp.json		http://purl.obolibrary.org/obo/HP_0011398		
HP:0011399	biolink:PhenotypicFeature	Tibialis anterior muscle atrophy	Wasting of the tibialis anterior muscle.	UMLS:C4023375	hp.json	Tibialis muscle degeneration|Sharp shin sign|Tibialis anterior amyotrophy	http://purl.obolibrary.org/obo/HP_0011399		
GO:0002244	biolink:BiologicalProcess	hematopoietic progenitor cell differentiation	The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.		hp.json	haematopoietic progenitor cell differentiation|haemopoietic progenitor cell differentiation|hemopoietic progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_0002244		
GO:0002246	biolink:BiologicalProcess	wound healing involved in inflammatory response	The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.		hp.json	inflammatory response wound healing|healing during inflammatory response	http://purl.obolibrary.org/obo/GO_0002246		
HP:0410209	biolink:PhenotypicFeature	Folate deficiency in CSF	A reduced concentration of folic acid, which is also known as vitamin B9 in the cerebrospinal fluid.		hp.json	Folate deficiency in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0410209		
HP:0410208	biolink:PhenotypicFeature	Positive plasma/serum cotinine test	Detection of cotinine, an alkaloid found in tobacco and the predominant metabolite of nicotine, in plasma or serum.		hp.json		http://purl.obolibrary.org/obo/HP_0410208		
HP:0011390	biolink:PhenotypicFeature	Morphological abnormality of the inner ear	A structural anomaly of the internal part of the ear.	UMLS:C4023381	hp.json		http://purl.obolibrary.org/obo/HP_0011390		
HP:0011391	biolink:PhenotypicFeature	Morphological abnormality of the nerves of the inner ear		UMLS:C4023380	hp.json		http://purl.obolibrary.org/obo/HP_0011391		
HP:0011392	biolink:PhenotypicFeature	Abnormality of the vestibular nerve		UMLS:C4023379	hp.json		http://purl.obolibrary.org/obo/HP_0011392		
HP:0011393	biolink:PhenotypicFeature	Aplasia of the vestibular nerve.	Absence of the vestibular nerve	UMLS:C4021153|UMLS:C4020751	hp.json	Absent cranial nerve viii|Absent vestribular nerve|Aplasia of cranial nerve VIII|Aplasia of the eighth cranial nerve|Absent the eighth cranial nerve	http://purl.obolibrary.org/obo/HP_0011393		
HP:0011394	biolink:PhenotypicFeature	Hypoplasia of the vestibular nerve	Underdevelopment of the vestibular nerve.	UMLS:C4020750	hp.json	Hypoplasia of cranial nerve VIII|Hypoplasia of the eighth cranial nerve|Thin vestibular nerve	http://purl.obolibrary.org/obo/HP_0011394		
HP:0410203	biolink:PhenotypicFeature	Positive gastric fluid barbiturate test	Detection of barbiturate metabolites such as phenobarbital in the gastric fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0410203		
HP:0410202	biolink:PhenotypicFeature	Positive stool barbiturate test	Detection of barbiturate metabolites such as phenobarbital in the stool.		hp.json		http://purl.obolibrary.org/obo/HP_0410202		
HP:0410201	biolink:PhenotypicFeature	Positive hair barbiturate test	Detection of barbiturate metabolites such as phenobarbital in the hair.		hp.json		http://purl.obolibrary.org/obo/HP_0410201		
HP:0410200	biolink:PhenotypicFeature	Positive meconium barbiturate test	Detection of barbiturate metabolites such as phenobarbital in meconium.		hp.json		http://purl.obolibrary.org/obo/HP_0410200		
HP:0410207	biolink:PhenotypicFeature	Positive methadone plasma/serum test	Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in plasma or serum.		hp.json		http://purl.obolibrary.org/obo/HP_0410207		
GO:0016885	biolink:MolecularActivity	ligase activity, forming carbon-carbon bonds	Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.	EC:6.4.-.-	hp.json		http://purl.obolibrary.org/obo/GO_0016885		
HP:0410206	biolink:PhenotypicFeature	Increased circulating nicotinurate level	An increased amount of nicotinurate in the blood.		hp.json	Increased circulating N-nicotinoylglycine level	http://purl.obolibrary.org/obo/HP_0410206		
HP:0410205	biolink:PhenotypicFeature	Abnormal circulating nicotinurate concentration	Any deviation from the normal concentration of nicotinurate in the blood.		hp.json	Abnormal circulating N-nicotinoylglycine level|Abnormal circulating nicotinurate level	http://purl.obolibrary.org/obo/HP_0410205		
HP:0410204	biolink:PhenotypicFeature	Increased intestinal transit time	An increase in the length of time required for food to pass through the intestines.		hp.json		http://purl.obolibrary.org/obo/HP_0410204		
HP:0011384	biolink:PhenotypicFeature	Abnormality of the internal auditory canal	An abnormality of the Internal acoustic meatus, i.e., of the canal in the petrous part of the temporal bone through which the cranial nerve VII and cranial nerve VIII traverse.	UMLS:C4021155	hp.json	Abnormality of the internal acoustic meatus	http://purl.obolibrary.org/obo/HP_0011384		
UBERON:5003635	biolink:AnatomicalEntity	pedal digit 5 plus metapodial segment	A subdivision of the autopod consisting of pedal digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	pedal digit V plus metapodial segment|pedal digit 5 digitopodial subdivision|pedal digit 5|pedal digit 5 ( phalanges plus metapodial) plus soft tissue|pedal digit 5 ray	http://purl.obolibrary.org/obo/UBERON_5003635		
HP:0011385	biolink:PhenotypicFeature	Absent internal auditory canal	Aplasia of the internal auditory canal.	UMLS:C4023384	hp.json		http://purl.obolibrary.org/obo/HP_0011385		
HP:0011386	biolink:PhenotypicFeature	Narrow internal auditory canal	Reduction in diameter of the internal auditory canal.	UMLS:C4023383	hp.json		http://purl.obolibrary.org/obo/HP_0011386		
HP:0011387	biolink:PhenotypicFeature	Enlarged vestibular aqueduct	Increased size of the vestibular aqueduct.	MSH:C566366|UMLS:C1863752	hp.json	Widened vestibular aqueduct|Dilated vestibular aqueduct	http://purl.obolibrary.org/obo/HP_0011387		
UBERON:5003632	biolink:AnatomicalEntity	pedal digit 2 plus metapodial segment	A subdivision of the autopod consisting of pedal digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	pedal digit 2|pedal digit II plus metapodial segment|pedal digit 2 digitopodial subdivision|pedal digit 2 ( phalanges plus metapodial) plus soft tissue|pedal digit 2 ray	http://purl.obolibrary.org/obo/UBERON_5003632		
HP:0011388	biolink:PhenotypicFeature	Enlarged cochlear aqueduct	Increased size of the cochlear duct, i.e., of a duct that communicates between the perilymphatic space and the subarachnoid space, and transmits a vein from the cochlea to join the internal jugular.	UMLS:C4021154	hp.json	Dilated cochlear aqueduct	http://purl.obolibrary.org/obo/HP_0011388		
HP:0011389	biolink:PhenotypicFeature	Functional abnormality of the inner ear	An abnormality of the function of the inner ear.	UMLS:C4023382	hp.json	Functional abnormality of the inner ear	http://purl.obolibrary.org/obo/HP_0011389		
UBERON:5003631	biolink:AnatomicalEntity	pedal digit 1 plus metapodial segment	A subdivision of the autopod consisting of pedal digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	pedal digit 1|pedal digit 1 digitopodial subdivision|pedal digit I plus metapodial segment|pedal digit 1 ( phalanges plus metapodial) plus soft tissue|pedal digit 1 ray	http://purl.obolibrary.org/obo/UBERON_5003631		
UBERON:5003634	biolink:AnatomicalEntity	pedal digit 4 plus metapodial segment	A subdivision of the autopod consisting of pedal digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	pedal digit 4|pedal digit IV plus metapodial segment|pedal digit 4 ( phalanges plus metapodial) plus soft tissue|pedal digit 4 ray|pedal digit 4 digitopodial subdivision	http://purl.obolibrary.org/obo/UBERON_5003634		
UBERON:5003633	biolink:AnatomicalEntity	pedal digit 3 plus metapodial segment	A subdivision of the autopod consisting of pedal digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	pedal digit 3|pedal digit 3 ( phalanges plus metapodial) plus soft tissue|pedal digit III plus metapodial segment|pedal digit 3 digitopodial subdivision|pedal digit 3 ray	http://purl.obolibrary.org/obo/UBERON_5003633		
GO:0002250	biolink:BiologicalProcess	adaptive immune response	An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).	Wikipedia:Adaptive_immune_system	hp.json	acquired immune response|immune memory response	http://purl.obolibrary.org/obo/GO_0002250		
GO:0002251	biolink:NamedThing	organ or tissue specific immune response			hp.json		http://purl.obolibrary.org/obo/GO_0002251		
GO:0002252	biolink:BiologicalProcess	immune effector process	Any process of the immune system that executes a component of an immune response. An effector immune process takes place after its activation.		hp.json		http://purl.obolibrary.org/obo/GO_0002252		
GO:0002253	biolink:BiologicalProcess	activation of immune response	Any process that initiates an immune response.		hp.json		http://purl.obolibrary.org/obo/GO_0002253		
HP:0011380	biolink:PhenotypicFeature	Morphological abnormality of the semicircular canal	An abnormality of the morphology of the semicircular canal.	UMLS:C4023386	hp.json		http://purl.obolibrary.org/obo/HP_0011380		
HP:0011381	biolink:PhenotypicFeature	Aplasia of the semicircular canal	Absence of the semicircular canal.	UMLS:C4023385	hp.json	Absent semicircular canal	http://purl.obolibrary.org/obo/HP_0011381		
HP:0011382	biolink:PhenotypicFeature	Hypoplasia of the semicircular canal	Underdevelopment of the semicircular canal.	UMLS:C3552156	hp.json	Small semicircular canal|Hypoplasia of the semicircular canals	http://purl.obolibrary.org/obo/HP_0011382		
HP:0011383	biolink:PhenotypicFeature	Enlarged semicircular canal	Increased size of the semicircular canal.	UMLS:C4021156	hp.json	Dilated semicircular canal	http://purl.obolibrary.org/obo/HP_0011383		
OIO:SubsetProperty	biolink:NamedThing	subset_property			hp.json		http://www.geneontology.org/formats/oboInOwl#SubsetProperty		
HP:0001726	biolink:PhenotypicFeature	obsolete Increased prevalence of valvular disease			hp.json		http://purl.obolibrary.org/obo/HP_0001726		
HP:0001723	biolink:PhenotypicFeature	Restrictive cardiomyopathy	Restrictive left ventricular physiology is characterized by a pattern of ventricular filling in which increased stiffness of the myocardium causes ventricular pressure to rise precipitously with only small increases in volume, defined as restrictive ventricular physiology in the presence of normal or reduced diastolic volumes (of one or both ventricles), normal or reduced systolic volumes, and normal ventricular wall thickness.	UMLS:C0007196|MSH:D002313|SNOMEDCT_US:90828009|SNOMEDCT_US:415295002	hp.json		http://purl.obolibrary.org/obo/HP_0001723		
HP:0001724	biolink:PhenotypicFeature	obsolete Aortic dilatation			hp.json		http://purl.obolibrary.org/obo/HP_0001724		
HP:0001727	biolink:PhenotypicFeature	Thromboembolic stroke	A cerebrovascular accident (stroke) that occurs because of thromboembolism.	UMLS:C1112433	hp.json		http://purl.obolibrary.org/obo/HP_0001727		
HP:0410346	biolink:PhenotypicFeature	Increased urinary galactosylated oligosaccharide	An abnormal increase in the concentration of galactosylated oligosaccharides in urine.		hp.json	Increased concentration of galactosylated oligosaccharides in urine	http://purl.obolibrary.org/obo/HP_0410346		
HP:0410345	biolink:PhenotypicFeature	Increased urinary polyhexose	An abnormal increase in the concentration of polyhexose in the urine.		hp.json	Increased polyhexose concentration in urine	http://purl.obolibrary.org/obo/HP_0410345		
HP:0410344	biolink:PhenotypicFeature	Shortened O-fucosylated glycan on properdin	Decreased length of O-fucosylated glycans present on properdin.		hp.json	Presence of terminal O-fucose glycans on properdin	http://purl.obolibrary.org/obo/HP_0410344		
HP:0410343	biolink:PhenotypicFeature	Decreased circulating heparan sulfate level	An abnormal decrease in the concentration of heparan sulfate in the blood.		hp.json	Decreased blood heparan sulfate concentration|Decreased blood heparan sulphate concentration|Decreased circulating heparan sulphate level	http://purl.obolibrary.org/obo/HP_0410343		
HP:0410349	biolink:PhenotypicFeature	Decreased glycosyltransferase O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase level	An abnormal decrease in glycosyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase enzymatic level.		hp.json		http://purl.obolibrary.org/obo/HP_0410349		
HP:0001722	biolink:PhenotypicFeature	High-output congestive heart failure	A form of heart failure characterized by elevated cardiac output. This may be seen in patients with heart failure and hyperthyroidism, anemia, pregnancy, arteriovenous fistulae, and others.	UMLS:C0742747	hp.json		http://purl.obolibrary.org/obo/HP_0001722		
HP:0410348	biolink:PhenotypicFeature	Increased urinary multiantennary sialylated oligosaccharide	An abnormal increase in the concentration of multiantennary sialylated oligosaccharides in the urine.		hp.json	Increase concentration of multiantennary sialylated oligosaccharides in urine	http://purl.obolibrary.org/obo/HP_0410348		
HP:0410347	biolink:PhenotypicFeature	Increased urinary high-mannose-type oligosaccharide	An abnormal increase in the concentration of high-mannose-type oligosaccharides in the urine.		hp.json	Increased concentration of high-mannose-type oligosaccharides in urine	http://purl.obolibrary.org/obo/HP_0410347		
UBERON:0008188	biolink:AnatomicalEntity	tendon of biceps brachii	A tendon that attaches_to a biceps brachii.	EMAPA:25053|FMA:38152	hp.json	tendon of biceps brachii muscle|biceps brachii tendon	http://purl.obolibrary.org/obo/UBERON_0008188		
HP:0410342	biolink:PhenotypicFeature	Increased circulating heparan sulfate level	An abnormal increase in the concentration of heparan sulfate in the blood.		hp.json	Increased circulating heparan sulphate level|Increased blood heparan sulphate concentration|Increased blood heparan sulfate concentration	http://purl.obolibrary.org/obo/HP_0410342		
HP:0410341	biolink:PhenotypicFeature	Abnormal circulating heparan sulfate level	An abnormal level of heparan sulfate in the blood.		hp.json	Abnormality of the concentration of heparan sulfate in the blood|Abnormal circulating heparan sulphate level|Abnormality of the concentration of heparan sulphate in the blood	http://purl.obolibrary.org/obo/HP_0410341		
HP:0410340	biolink:PhenotypicFeature	Focal epithelial hyperplasia of oral mucosa	The occurrence of multiple or unique whitish or normal in color small papules or nodules in oral cavity, especially on labial and buccal mucosa, lower lip and tongue, and less often on the upper lip, gingiva and palate.		hp.json	Focal epithelial hyperplasia of the lining of mouth|Oral mucosa epithelial hyperplasia	http://purl.obolibrary.org/obo/HP_0410340		
HP:0001737	biolink:PhenotypicFeature	Pancreatic cysts	A cyst of the pancreas that possess a lining of mucous epithelium.	SNOMEDCT_US:31258000|UMLS:C0030283|MSH:D010181|UMLS:C1860394	hp.json	Pancreatic cysts|Multiple pancreatic cysts|Pancreatic cyst	http://purl.obolibrary.org/obo/HP_0001737		
HP:0001734	biolink:PhenotypicFeature	Annular pancreas	A congenital anomaly in which the pancreas completely (or sometimes incompletely) encircles the second portion of duodenum and occasionally obstructs the more proximal duodenum.	UMLS:C0149955|MSH:C536376|SNOMEDCT_US:40315008	hp.json		http://purl.obolibrary.org/obo/HP_0001734		
HP:0001735	biolink:PhenotypicFeature	Acute pancreatitis	A acute form of pancreatitis.	SNOMEDCT_US:197456007|UMLS:C0001339	hp.json	Pancreatitis, acute|Acute pancreatic inflammation	http://purl.obolibrary.org/obo/HP_0001735		
HP:0001738	biolink:PhenotypicFeature	Exocrine pancreatic insufficiency	Impaired function of the exocrine pancreas associated with a reduced ability to digest foods because of lack of digestive enzymes.	MSH:D010188|SNOMEDCT_US:47367009|UMLS:C0267963|SNOMEDCT_US:37992001|UMLS:C0030293	hp.json	Pancreatic insufficiency|Inability to properly digest food due to lack of pancreatic digestive enzymes	http://purl.obolibrary.org/obo/HP_0001738		
HP:0001739	biolink:PhenotypicFeature	Abnormal nasopharynx morphology	A structural anomaly of the nasopharynx.	UMLS:C4025750	hp.json	Abnormality of the nasopharynx	http://purl.obolibrary.org/obo/HP_0001739		
HP:0410335	biolink:PhenotypicFeature	Insect allergy	Hypersensitivity in form of an adverse immune reaction against insects.		hp.json	Allergy to insects|IgE-mediated insect allergy|Immunoglobulin E-mediated insect allergy|Insect allergy	http://purl.obolibrary.org/obo/HP_0410335		
HP:0410334	biolink:PhenotypicFeature	Fungi allergy	Hypersensitivity in form of an adverse immune reaction against fungus.		hp.json	Immunoglobulin E-mediated fungi allergy|Fungi allergy|IgE-mediated fungi allergy|Fungus allergy|Allergy to fungi|Fungal allergy	http://purl.obolibrary.org/obo/HP_0410334		
HP:0410333	biolink:PhenotypicFeature	Seafood allergy	Hypersensitivity in form of an adverse immune reaction against seafood.		hp.json	Immunoglobulin E-mediated seafood allergy|Seafood allergy|IgE-mediated seafood allergy|Allergy to seafood	http://purl.obolibrary.org/obo/HP_0410333		
HP:0410332	biolink:PhenotypicFeature	Plant based food allergy	Hypersensitivity in form of an adverse immune reaction against plant based food allergens.		hp.json	IgE-mediated plant based food allergen allergy|Plant based food allergy|Allergy to plant based food allergens|Immunoglobulin E-mediated plant based food allergen allergy	http://purl.obolibrary.org/obo/HP_0410332		
HP:0001732	biolink:PhenotypicFeature	Abnormality of the pancreas	An abnormality of the pancreas.	SNOMEDCT_US:3855007|UMLS:C4025751|UMLS:C0030286|MSH:D010182	hp.json	Pancreatic disease|Abnormality of the pancreas	http://purl.obolibrary.org/obo/HP_0001732		
HP:0410339	biolink:PhenotypicFeature	Insect bite allergy	Hypersensitivity in form of an adverse immune reaction against insect bites.		hp.json	Allergy to insect bites|Immunoglobulin E-mediated insect bite allergy|Insect bite allergy|IgE-mediated insect bite allergy	http://purl.obolibrary.org/obo/HP_0410339		
HP:0001733	biolink:PhenotypicFeature	Pancreatitis	The presence of inflammation in the pancreas.	MSH:D010195|SNOMEDCT_US:75694006|UMLS:C0030305	hp.json	Pancreatic inflammation	http://purl.obolibrary.org/obo/HP_0001733		
HP:0410338	biolink:PhenotypicFeature	Plant product allergy	Hypersensitivity in form of an adverse immune reaction against plant products.		hp.json	Plant product allergy|Immunoglobulin E-mediated plant product allergy|IgE-mediated plant product allergy|Allergy to plant products	http://purl.obolibrary.org/obo/HP_0410338		
HP:0410337	biolink:PhenotypicFeature	Parasite allergy	Hypersensitivity in form of an adverse immune reaction against parasites.		hp.json	Allergy to parasites|IgE-mediated parasite allergy|Immunoglobulin E-mediated parasite allergy|Parasite allergy	http://purl.obolibrary.org/obo/HP_0410337		
HP:0001730	biolink:PhenotypicFeature	Progressive hearing impairment	A progressive form of hearing impairment.	UMLS:C1842138	hp.json	Progressive hearing loss	http://purl.obolibrary.org/obo/HP_0001730		
HP:0410336	biolink:PhenotypicFeature	Venom allergy	Hypersensitivity in form of an adverse immune reaction against insect venom.		hp.json	Allergy to venom|Venom allergy|Immunoglobulin E-mediated venom allergy|IgE-mediated venom allergy	http://purl.obolibrary.org/obo/HP_0410336		
HP:0410331	biolink:PhenotypicFeature	Nut food product allergy	Hypersensitivity in form of an adverse immune reaction against nut food products.		hp.json	Nut food product allergy|Nut allergy|Allergy to nut food products|IgE-mediated nut food product allergy|Immunoglobulin E-mediated nut food product allergy	http://purl.obolibrary.org/obo/HP_0410331		
HP:0410330	biolink:PhenotypicFeature	Meat allergen allergy	Hypersensitivity in form of an adverse immune reaction against allergens contained in meat products.		hp.json	Allergy to meat allergens|Meat allergy|Immunoglobulin E-mediated meat allergen allergy|Meat allergen allergy|IgE-mediated meat allergen allergy	http://purl.obolibrary.org/obo/HP_0410330		
HP:0001709	biolink:PhenotypicFeature	Third degree atrioventricular block	Third-degree atrioventricular (AV) block (also referred to as complete heart block) is the complete dissociation of the atria and the ventricles. Third-degree AV block exists when more P waves than QRS complexes exist and no relationship (no conduction) exists between them.	SNOMEDCT_US:27885002|UMLS:C0151517	hp.json	Complete heart block|Third-degree heart block	http://purl.obolibrary.org/obo/HP_0001709		
HP:0001704	biolink:PhenotypicFeature	Tricuspid valve prolapse	One or more of the leaflets (cusps) of the tricuspid valve bulges back into the right atrium upon contraction of the right ventricle.	UMLS:C0040962|SNOMEDCT_US:253383003|Fyler:1733|MSH:D014263	hp.json		http://purl.obolibrary.org/obo/HP_0001704		
HP:0001701	biolink:PhenotypicFeature	Pericarditis	Inflammation of the sac-like covering around the heart (pericardium).	UMLS:C0031046|MSH:D010493|SNOMEDCT_US:3238004	hp.json	Swelling or irritation of membrane around heart	http://purl.obolibrary.org/obo/HP_0001701		
HP:0001702	biolink:PhenotypicFeature	Abnormal tricuspid valve morphology	Any structural anomaly of the tricuspid valve.	UMLS:C4025753|EPCC:06.01.00	hp.json	Abnormality of the tricuspid valve	http://purl.obolibrary.org/obo/HP_0001702		
HP:0001707	biolink:PhenotypicFeature	Abnormal right ventricle morphology	An abnormality of the right ventricle of the heart.	SNOMEDCT_US:253516002|UMLS:C0344887|Fyler:1820	hp.json	Right ventricular abnormality|Abnormality of the right ventricle	http://purl.obolibrary.org/obo/HP_0001707		
HP:0001708	biolink:PhenotypicFeature	Right ventricular failure	Reduced ability of the right ventricle to perform its function (to receive blood from the right atrium and to eject blood into the pulmonary artery), often leading to pitting peripheral edema, ascites, and hepatomegaly.	UMLS:C2939447|SNOMEDCT_US:128404006|SNOMEDCT_US:367363000|UMLS:C0235527|MSH:D006333	hp.json	Right ventricular impairment|Impaired right ventricular function|Right-sided heart failure	http://purl.obolibrary.org/obo/HP_0001708		
HP:0001705	biolink:PhenotypicFeature	Right ventricular outlet tract obstruction	An obstruction to the forward flow of blood in the outflow tract of the right ventricle.	MSH:D014694|UMLS:C0035619	hp.json	Right ventricular outlet obstruction	http://purl.obolibrary.org/obo/HP_0001705		
HP:0001706	biolink:PhenotypicFeature	Endocardial fibroelastosis	Diffuse thickening of the ventricular endocardium and by associated myocardial dysfunction	SNOMEDCT_US:65457005|UMLS:C0014117|MSH:D004695	hp.json		http://purl.obolibrary.org/obo/HP_0001706		
HP:0410368	biolink:PhenotypicFeature	Increased globoside Gb3 level	An abnormal increase in the concentration of glycolipid globoside Gb3.		hp.json	Increased globoside Gb3 concentration	http://purl.obolibrary.org/obo/HP_0410368		
HP:0410367	biolink:PhenotypicFeature	Increased hepatitis A virus antibody level	An abnormally increased level of immunoglobulin against hepatitis A virus in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0410367		
HP:0410366	biolink:PhenotypicFeature	Increased globoside Gb4 level	An abnormal increase in the concentration of globoside Gb4.		hp.json	Increased globoside Gb4 concentration	http://purl.obolibrary.org/obo/HP_0410366		
HP:0410365	biolink:PhenotypicFeature	Increased disialylated core 1 O-glycan level	An abnormal increase in the concentration of disialylated core 1 O-glycans on glycoproteins.		hp.json	Increased disialyl T-antigen concentration	http://purl.obolibrary.org/obo/HP_0410365		
HP:0001700	biolink:PhenotypicFeature	Myocardial necrosis	Irreversible damage to heart tissue (myocardium) due to lack of oxygen after a heart attack (myocardial infarction).	SNOMEDCT_US:251061000|UMLS:C1442837	hp.json		http://purl.obolibrary.org/obo/HP_0001700		
HP:0410369	biolink:PhenotypicFeature	Increased hepatitis B virus antibody level	An abnormally increased level of immunoglobulin against hepatitis B virus in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0410369		
HP:0410360	biolink:PhenotypicFeature	Increased core 1 O-glycan level	An abnormal increase in the concentration of core 1 O-glycans on glycoproteins.		hp.json	Increased T-antigen concentration	http://purl.obolibrary.org/obo/HP_0410360		
HP:0410364	biolink:PhenotypicFeature	Decreased monosialylated core 1 O-glycan level	An abnormal decrease in the concentration of monosialylated core 1 O-glycans on glycoproteins.		hp.json	Decreased sialyl T-antigen concentration	http://purl.obolibrary.org/obo/HP_0410364		
HP:0410363	biolink:PhenotypicFeature	Increased monosialylated core 1 O-glycan level	An abnormal increase in the concentration of monosialylated core 1 O-glycans on glycoproteins.		hp.json	Increased sialyl T-antigen concentration	http://purl.obolibrary.org/obo/HP_0410363		
HP:0410362	biolink:PhenotypicFeature	Decreased O-mannosyl glycans on alpha-dystroglycan	Hypoglycosylation of alpha-dystroglycan with O-mannosyl glycans. Alpha-dystroglycan is a functional target of O-mannosyl glycosylation and functional glycosylation of alpha-DG is essential in its interaction with the extracellular matrix.		hp.json	Reduced O-mannosyl glycans on alpha-dystroglycan	http://purl.obolibrary.org/obo/HP_0410362		
HP:0410361	biolink:PhenotypicFeature	Decreased core 1 O-glycan level	An abnormal decrease in the concentration of core 1 O-glycans on glycoproteins.		hp.json	Decreased T-antigen concentration	http://purl.obolibrary.org/obo/HP_0410361		
HP:0001714	biolink:PhenotypicFeature	Ventricular hypertrophy	Enlargement of the cardiac ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy.	UMLS:C0340279|SNOMEDCT_US:266249003	hp.json		http://purl.obolibrary.org/obo/HP_0001714		
HP:0001712	biolink:PhenotypicFeature	Left ventricular hypertrophy	Enlargement or increased size of the heart left ventricle.	Fyler:3608|SNOMEDCT_US:55827005|MSH:D017379|UMLS:C0149721	hp.json	Left ventricular wall hypertrophy|Heart left ventricle hypertrophy	http://purl.obolibrary.org/obo/HP_0001712		
HP:0001713	biolink:PhenotypicFeature	Abnormal cardiac ventricle morphology	An abnormality of a cardiac ventricle.	UMLS:C4025752	hp.json	Abnormality of cardiac ventricle	http://purl.obolibrary.org/obo/HP_0001713		
HP:0001718	biolink:PhenotypicFeature	Mitral stenosis	An abnormal narrowing of the orifice of the mitral valve.	SNOMEDCT_US:79619009|MSH:D008946|ICD-10:Q23.2|EPCC:06.02.92|UMLS:C0026269|Fyler:1511	hp.json	Mitral valve stenosis	http://purl.obolibrary.org/obo/HP_0001718		
HP:0001719	biolink:PhenotypicFeature	Double outlet right ventricle	Double outlet right ventricle (DORV) is a type of ventriculoarterial connection in which both great vessels arise entirely or predominantly from the right ventricle.	Fyler:600|MSH:D004310|UMLS:C0013069|Fyler:606|SNOMEDCT_US:7484005	hp.json	Double-outlet right ventricle|DORV	http://purl.obolibrary.org/obo/HP_0001719		
HP:0001716	biolink:PhenotypicFeature	Wolff-Parkinson-White syndrome	A disorder of the cardiac conduction system of the heart characterized by ventricular preexcitation due to the presence of an abnormal accessory atrioventricular electrical conduction pathway.	UMLS:C0043202|SNOMEDCT_US:74390002|MSH:D014927	hp.json		http://purl.obolibrary.org/obo/HP_0001716		
HP:0001717	biolink:PhenotypicFeature	Coronary artery calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a coronary artery.	SNOMEDCT_US:445512009|UMLS:C1611184	hp.json		http://purl.obolibrary.org/obo/HP_0001717		
HP:0410357	biolink:PhenotypicFeature	Increased high-mannose N-glycan level	An abnormal increase in the concentration of high-mannose N-glycans on glycoproteins.		hp.json	Increased high-mannose N-glycans on glycoprotein concentration	http://purl.obolibrary.org/obo/HP_0410357		
HP:0410356	biolink:PhenotypicFeature	Abnormal high-mannose N-glycan level	An abnormal concentration of high-mannose N-glycans on glycoproteins.		hp.json	Abnormal high-mannose N-glycans on glycoprotein concentration	http://purl.obolibrary.org/obo/HP_0410356		
HP:0410355	biolink:PhenotypicFeature	Decreased sialylated N-glycan level	An abnormal decrease in the concentration of sialylated N-glycans on glycoproteins.		hp.json	Decreased concentration of sialylated N-glycans on glycoproteins	http://purl.obolibrary.org/obo/HP_0410355		
HP:0410354	biolink:PhenotypicFeature	Increased sialylated N-glycan level	An abnormal increase in the concentration of sialylated N-glycans on glycoproteins.		hp.json	Increased concentration of sialylated N-glycans on glycoproteins	http://purl.obolibrary.org/obo/HP_0410354		
HP:0001710	biolink:PhenotypicFeature	Conotruncal defect	A congenital malformation of the outflow tract of the heart. Conotruncal defects are thought to result from a disturbance of the outflow tract of the embryonic heart, and comprise truncus arteriosus, tetralogy of Fallot, interrupted aortic arch, transposition of the great arteries, and double outlet right ventricle.	UMLS:C1853238	hp.json	Conotruncal heart defects	http://purl.obolibrary.org/obo/HP_0001710		
HP:0001711	biolink:PhenotypicFeature	Abnormal left ventricle morphology	Any structural abnormality of the left ventricle of the heart.	Fyler:1810|SNOMEDCT_US:253535002|UMLS:C0344905	hp.json	Left ventricular abnormality|Abnormal heart left ventricle morphology|Abnormality of the left ventricle	http://purl.obolibrary.org/obo/HP_0001711		
HP:0410359	biolink:PhenotypicFeature	Abnormal core 1 O-glycan level	An abnormal in the concentration of core 1 O-glycans on glycoproteins.		hp.json	Abnormal concentration of T-antigen	http://purl.obolibrary.org/obo/HP_0410359		
HP:0410358	biolink:PhenotypicFeature	Decreased high-mannose N-glycan level	An abnormal decrease in the concentration of high-mannose N-glycans on glycoproteins.		hp.json	Decreased high-mannose N-glycans on glycoprotein concentration	http://purl.obolibrary.org/obo/HP_0410358		
HP:0410353	biolink:PhenotypicFeature	Decreased complex N-glycan level	An abnormal decrease in the concentration of complex N-glycans on glycoproteins.		hp.json	Increased truncated complex N-glycans on glycoproteins	http://purl.obolibrary.org/obo/HP_0410353		
HP:0410352	biolink:PhenotypicFeature	Increased complex N-glycan level	An abnormal increase in the concentration of complex N-glycans on glycoproteins.		hp.json	Increased concentration of complex N-glycans on glycoproteins	http://purl.obolibrary.org/obo/HP_0410352		
HP:0410351	biolink:PhenotypicFeature	Abnormal complex N-glycan level	An abnormal concentration of complex N-glycans on glycoproteins.		hp.json	Abnormal concentration of complex N-glycans on glycoproteins	http://purl.obolibrary.org/obo/HP_0410351		
HP:0410350	biolink:PhenotypicFeature	Increased urinary fucosylated oligosaccharide	An abnormal increase in the concentrationl of small fucosylated oligosaccharides in the urine.		hp.json	Increased concentration of fucosylated oligosaccharides in urine	http://purl.obolibrary.org/obo/HP_0410350		
HP:0001769	biolink:PhenotypicFeature	Broad foot	A foot for which the measured width is above the 95th centile for age; or, a foot that appears disproportionately wide for its length.	UMLS:C1866241	hp.json	Wide foot|Broad foot|Broad feet	http://purl.obolibrary.org/obo/HP_0001769		hposlim_core
UBERON:0035764	biolink:AnatomicalEntity	pulmonary lymph node		FMA:5968	hp.json	intrapulmonary lymph node|pulmonary node	http://purl.obolibrary.org/obo/UBERON_0035764		
UBERON:0035763	biolink:AnatomicalEntity	cavity of cardiac chamber		EHDAA2:0004181|FMA:9464	hp.json	cardiac chamber cavity|heart cavity|heart lumen	http://purl.obolibrary.org/obo/UBERON_0035763		
HP:0001761	biolink:PhenotypicFeature	Pes cavus	The presence of an unusually high plantar arch. Also called high instep, pes cavus refers to a distinctly hollow form of the sole of the foot when it is bearing weight.	SNOMEDCT_US:205091006|MEDDRA:10034743|UMLS:C0728829	hp.json	High-arched foot	http://purl.obolibrary.org/obo/HP_0001761		hposlim_core
HP:0001762	biolink:PhenotypicFeature	Talipes equinovarus	Talipes equinovarus (also called clubfoot) typically has four main components: inversion and adduction of the forefoot; inversion of the heel and hindfoot; equinus (limitation of extension) of the ankle and subtalar joint; and internal rotation of the leg.	MEDDRA:10043106|SNOMEDCT_US:397932003|SNOMEDCT_US:249808002|MSH:D003025|Fyler:4171|UMLS:C0009081	hp.json	Foot, talipes equinovarus|Equinovarus|Pes equinovarus|Talipes varus|Club foot|Club feet|Clubbing of feet|Clubfoot|Clubfeet|Pes equinus	http://purl.obolibrary.org/obo/HP_0001762		hposlim_core
HP:0410389	biolink:PhenotypicFeature	Decreased proportion of central memory CD8-positive, alpha-beta T cells	A reduced proportion of CD8-positive, alpha-beta central memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json		http://purl.obolibrary.org/obo/HP_0410389		
HP:0410388	biolink:PhenotypicFeature	Decreased proportion of central memory CD4-positive, alpha-beta T cells	A reduced proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json	Reduced proportion of CD4+ central memory cells|Decreased proportion of CD4-positive central memory cells|Decreased proportion of central memory CD4+, alpha-beta T cell|Decreased proportion of CD4+ central memory cells	http://purl.obolibrary.org/obo/HP_0410388		
HP:0025730	biolink:PhenotypicFeature	Foramen ovale aneurysm	Foramen ovale aneurysm (FOA) or atrial septal aneurysm is abnormal redundancy of the atrial septum primum, with bulging of the septum by at least half the width of the atrial chamber, or by at least 10 mm beyond the level of the atrial septum. The abnormal protrusion of the interatrial septum results in decreased left atrial volume. On color Doppler there is reduced left ventricular inflow.		hp.json	Redundant septum primum flap|Fetal atrial septal dilatation	http://purl.obolibrary.org/obo/HP_0025730		
HP:0410387	biolink:PhenotypicFeature	obsolete Decreased proportion of effector memory CD4-positive, alpha-beta T cells			hp.json		http://purl.obolibrary.org/obo/HP_0410387		
HP:0001760	biolink:PhenotypicFeature	Abnormal foot morphology	An abnormality of the skeleton of foot.	SNOMEDCT_US:229844004|UMLS:C0016506|MSH:D005530	hp.json	Abnormality of the feet|Abnormality of the foot|Abnormal feet structure|Foot deformity|Foot deformities	http://purl.obolibrary.org/obo/HP_0001760		
HP:0001765	biolink:PhenotypicFeature	Hammertoe	Hyperextension of the metatarsal-phalangeal joint with hyperflexion of the proximal interphalangeal (PIP) joint.	UMLS:C1136179|SNOMEDCT_US:122481008|MSH:D037801	hp.json	Hammer toe|Hammertoes|Hammertoe	http://purl.obolibrary.org/obo/HP_0001765		hposlim_core
HP:0001763	biolink:PhenotypicFeature	Pes planus	A foot where the longitudinal arch of the foot is in contact with the ground or floor when the individual is standing; or, in a patient lying supine, a foot where the arch is in contact with the surface of a flat board pressed against the sole of the foot by the examiner with a pressure similar to that expected from weight bearing; or, the height of the arch is reduced.	UMLS:C0016202|SNOMEDCT_US:53226007|SNOMEDCT_US:203534009|MSH:D005413|UMLS:C0264133	hp.json	Dropped arches|Fallen arches|Flat feet|Flat foot	http://purl.obolibrary.org/obo/HP_0001763		hposlim_core
HP:0410382	biolink:PhenotypicFeature	obsolete Abnormal proportion of effector memory CD4-positive, alpha-beta T cells			hp.json		http://purl.obolibrary.org/obo/HP_0410382		
HP:0410381	biolink:PhenotypicFeature	Abnormal proportion of central memory CD4-positive, alpha-beta T cells	An abnormal proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json		http://purl.obolibrary.org/obo/HP_0410381		
HP:0410380	biolink:PhenotypicFeature	Abnormal proportion of CD8-positive, alpha-beta memory T cells	An abnormal proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. A CD8-positive, alpha-beta T cell with memory phenotype is CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.		hp.json		http://purl.obolibrary.org/obo/HP_0410380		
HP:0410386	biolink:PhenotypicFeature	Decreased proportion of CD4-positive, alpha-beta memory T cells	Decresaed proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.		hp.json		http://purl.obolibrary.org/obo/HP_0410386		
HP:0410385	biolink:PhenotypicFeature	Decreased proportion of CD8-positive, alpha-beta memory T cells	Decreased proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. A CD8-positive, alpha-beta T cell with memory phenotype is CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.		hp.json		http://purl.obolibrary.org/obo/HP_0410385		
HP:0410384	biolink:PhenotypicFeature	Abnormal proportion of central memory CD8-positive, alpha-beta T cells	An abnormal proportion of central memory CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json		http://purl.obolibrary.org/obo/HP_0410384		
HP:0410383	biolink:PhenotypicFeature	Abnormal proportion of effector memory CD8-positive, alpha-beta T cells	An abnormal proportion of effector memory CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json		http://purl.obolibrary.org/obo/HP_0410383		
HP:0025725	biolink:PhenotypicFeature	Type 1 congenital pulmonary airway malformation	A type of congenital pulmonary airway malformation that is characterized by multiple large cysts or a single dominant cyst.		hp.json		http://purl.obolibrary.org/obo/HP_0025725		
HP:0025726	biolink:PhenotypicFeature	Type 2 congenital pulmonary airway malformation	A type of congenital pulmonary airway malformation that is characterized by multiple evenly spaced cysts (sponge-like appearance).		hp.json		http://purl.obolibrary.org/obo/HP_0025726		
HP:0025727	biolink:PhenotypicFeature	Type 3 congenital pulmonary airway malformation	A type of congenital pulmonary airway malformation that is characterized by a bulky firm mass with an adenomatoid appearance.		hp.json		http://purl.obolibrary.org/obo/HP_0025727		
HP:0025728	biolink:PhenotypicFeature	Periventricular pseudocyst	Pseudocysts that lack an epithelial lining, PVPCs are frequently observed in the caudothalamic groove or in the infero-lateral aspect of the frontal horns of the lateral ventricles, but may also be located elsewhere along the periventricular germinal matrix, as in the temporal or occipital horns.		hp.json		http://purl.obolibrary.org/obo/HP_0025728		
UBERON:0035775	biolink:AnatomicalEntity	submandibular region	The region between the mandible and the hyoid bone that contains the submandibular and sublingual glands, suprahyoid muscles, submandibular ganglion, and lingual artery.	FMA:57779	hp.json	submaxillary triangle|digastric triangle|submaxillary triangle|submandibular triangle|digastric triangle|trigonum submandibulare	http://purl.obolibrary.org/obo/UBERON_0035775		
HP:0025729	biolink:PhenotypicFeature	Fetal vascular malperfusion	The term fetal vascular malperfusion (FVM) is used to describe placental pathology that is throught to result from an obstruction in fetal blood flow that could result from a number of conditions (eg, umbilical cord lesions, hypercoagulability, complications of fetal cardiac dysfunction, such as hypoxia, etc.).		hp.json		http://purl.obolibrary.org/obo/HP_0025729		
UBERON:0035776	biolink:AnatomicalEntity	accessory ciliary ganglion	A parasympathetic ganglion located on the short ciliary nerve differentiated from the main ciliary ganglion by virtue of the fact that it had no root derived directly from the inferior trunk of the oculomotor nerve and it never attaches to this nerve.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035776		
HP:0410379	biolink:PhenotypicFeature	Abnormal proportion of CD4-positive, alpha-beta memory T cells	An abnormal proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.		hp.json		http://purl.obolibrary.org/obo/HP_0410379		
HP:0001772	biolink:PhenotypicFeature	Talipes equinovalgus	A deformity of foot and ankle in which the foot is bent down and outwards.	SNOMEDCT_US:68284008|MSH:D004863|UMLS:C0265642|UMLS:C4020866	hp.json	Equinovalgus deformity	http://purl.obolibrary.org/obo/HP_0001772		
UBERON:0035767	biolink:AnatomicalEntity	intrapulmonary bronchus		FMA:223208|NCIT:C12930	hp.json		http://purl.obolibrary.org/obo/UBERON_0035767		
HP:0001773	biolink:PhenotypicFeature	Short foot	A measured foot length that is more than 2 SD below the mean for a newborn of 27 - 41 weeks gestation, or foot that is less than the 3rd centile for individuals from birth to 16 years of age (objective). Alternatively, a foot that appears disproportionately short (subjective).	UMLS:C1848673	hp.json	Hypoplastic feet|Small feet|Short feet|Short foot	http://purl.obolibrary.org/obo/HP_0001773		
HP:0410378	biolink:PhenotypicFeature	Decreased proportion of naive CD4 T cells	An abnormally reduced proportion of naive CD4 T cells relative to the total number of T cells.		hp.json	Decreased proportion of naive thymus-derived CD4-positive, alpha-beta T cells|Reduced proportion of naive CD4 T cells|Decreased proportion of CD4+CD45RA+ cells	http://purl.obolibrary.org/obo/HP_0410378		
HP:0410377	biolink:PhenotypicFeature	Decreased proportion of naive CD8 T cells	An abnormally reduced proportion of naive CD8 T cells relative to the total number of T cells.		hp.json	Reduced proportion of naive thymus-derived CD8-positive, alpha-beta T cells|Reduced proportion of naive CD8 T cells	http://purl.obolibrary.org/obo/HP_0410377		
HP:0001770	biolink:PhenotypicFeature	Toe syndactyly	Webbing or fusion of the toes, involving soft parts only or including bone structure. Bony fusions are referred to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the toes in a proximo-distal axis are referred to as "Symphalangism".	SNOMEDCT_US:32113001|UMLS:C0265660	hp.json	Webbed toes|Syndactyly of toes|Fused toes|Foot syndactyly|Syndactyly of feet	http://purl.obolibrary.org/obo/HP_0001770		
HP:0001771	biolink:PhenotypicFeature	Achilles tendon contracture	A contracture of the Achilles tendon.	SNOMEDCT_US:203076007|UMLS:C0410264	hp.json	Contractures of the Achilles tendon|Tight achilles tendon|Achilles tendon contractures|Shortening of the achilles tendon	http://purl.obolibrary.org/obo/HP_0001771		
HP:0410376	biolink:PhenotypicFeature	Increased proportion of naive CD8 T cells	An abnormally increased proportion of naive CD8 T cells relative to the total number of T cells.		hp.json	Elevated proportion of naive thymus-derived CD8-positive, alpha-beta T cells|Elevated proportion of naive CD8 T cells	http://purl.obolibrary.org/obo/HP_0410376		
HP:0025720	biolink:PhenotypicFeature	Limited horizontal extraocular movement	Limited mobility of the eye to move from side to side (horizontally) within its socket.		hp.json		http://purl.obolibrary.org/obo/HP_0025720		
HP:0025721	biolink:PhenotypicFeature	Limited vertical extraocular movement	Limited mobility of the eye to move up and down (vertically) within its socket.		hp.json		http://purl.obolibrary.org/obo/HP_0025721		
HP:0001776	biolink:PhenotypicFeature	Bilateral talipes equinovarus	Bilateral clubfoot deformity (see HP:0001762).	UMLS:C1837835	hp.json	Bilateral clubfeet|Bilateral clubfoot|Club foot on both sides	http://purl.obolibrary.org/obo/HP_0001776		
HP:0025722	biolink:PhenotypicFeature	Cerebral infarct	A necrotic lesion in the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors.		hp.json		http://purl.obolibrary.org/obo/HP_0025722		
HP:0025723	biolink:PhenotypicFeature	Abnormal fetal skin morphology	Any structural anomaly of the skin of the fetus or newborn. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.		hp.json		http://purl.obolibrary.org/obo/HP_0025723		
HP:0001775	biolink:PhenotypicFeature	Tarsal osteovalgus		UMLS:C4025748	hp.json		http://purl.obolibrary.org/obo/HP_0001775		
HP:0025724	biolink:PhenotypicFeature	Caseous vernix-like desquamation	Vernix caseosa is a physiological, viscous biofilm that is produced by desquamated fetal skin and sebaceous glands covering the fetus at the third trimester in-utero. The substance's gross morphology in post-partum is described by the etymology, as vernix means varnish, and caseosa means cheesy-like matter. This finding refers to an abnormally thick and greasy vernix caseosa-like scale present at birth.		hp.json	Greasy, thick vernix caseosa-like scale	http://purl.obolibrary.org/obo/HP_0025724		
HP:0410371	biolink:PhenotypicFeature	Increased hepatitis C virus antibody level	An abnormally increased level of immunoglobulin against hepatitis C virus in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0410371		
HP:0410370	biolink:PhenotypicFeature	Absence of ganglioside GM3	The absence of ganglioside GM3.		hp.json		http://purl.obolibrary.org/obo/HP_0410370		
HP:0410375	biolink:PhenotypicFeature	Increased proportion of naive CD4 T cells			hp.json	Increased proportion of naive thymus-derived CD4-positive, alpha-beta T cells|Elevated proportion of naive CD4 T cells|Increased proportion of CD4+CD45RA+ cells	http://purl.obolibrary.org/obo/HP_0410375		
HP:0410374	biolink:PhenotypicFeature	Abnormal proportion of naive CD8 T cells	Any abnormality in the proportion of naive CD8 T cells relative to the total number of T cells.		hp.json		http://purl.obolibrary.org/obo/HP_0410374		
HP:0410373	biolink:PhenotypicFeature	Abnormal proportion of naive CD4 T cells	Any abnormality in the proportion of naive CD4 T cells relative to the total number of T cells.		hp.json	Abnormal proportion of naive thymus-derived CD4-positive, alpha-beta T cells|Abnormal proportion of CD4+CD45RA+ cells	http://purl.obolibrary.org/obo/HP_0410373		
HP:0410372	biolink:PhenotypicFeature	Increased Tn-antigen level	An abnormal increase in the concentration of Tn antigen on glycoproteins.		hp.json	Increased O-GalNac on glycoprotein concentration	http://purl.obolibrary.org/obo/HP_0410372		
HP:0001747	biolink:PhenotypicFeature	Accessory spleen	An accessory spleen is a round, iso-echogenic, homogenic and smooth structure and is seen as a normal variant mostly on the medial contour of the spleen, near the hilus or around the lower pole. This has no pathogenic relevance.	UMLS:C0266631|Fyler:4772|SNOMEDCT_US:10362008	hp.json		http://purl.obolibrary.org/obo/HP_0001747		
HP:0025714	biolink:PhenotypicFeature	Cerebral cortical microinfarct	An infarct located on the outer layer of the cerebrum that can only be observed microscopically. Cerebral microinfarcts are typically defined as sharply delimited microscopic regions of cellular death or tissue necrosis, sometimes with cavitation (that is, a central fluid-filled cavity). The term microscopic denotes that these lesions are not visible by gross inspection of the brain but seen by light microscopy. The term infarct is most commonly used for ischemia-related tissue loss, and indeed the pathologic appearance of microinfarcts is consistent with that of known ischemic infarctions.		hp.json		http://purl.obolibrary.org/obo/HP_0025714		
HP:0001748	biolink:PhenotypicFeature	Polysplenia	Polysplenia is a congenital disease manifested by multiple small accessory spleens.	UMLS:C1856659	hp.json	Multiple accessory spleens|Accessory spleens|Multiple small spleens	http://purl.obolibrary.org/obo/HP_0001748		
HP:0025715	biolink:PhenotypicFeature	Abnormal umbilical artery doppler waveform during pregnancy	Abnormal waveforms the Doppler sonographic examination of bloodflow in the umbilical artery. vUmbilical arterial Doppler assessment is used in surveillance of fetal health in the third trimester.		hp.json		http://purl.obolibrary.org/obo/HP_0025715		
UBERON:0035784	biolink:AnatomicalEntity	seminal clot	A portion of semen in a coagulated state.		hp.json	seminal coagulum	http://purl.obolibrary.org/obo/UBERON_0035784		
HP:0025716	biolink:PhenotypicFeature	Fetal anemia	Low hemoglobin/hematocrit in a fetus as evidenced by percutaneous umbilical cord sampling and Doppler ultrasonographic assessment of the peak velocity of systolic blood flow in the middle cerebral artery.		hp.json		http://purl.obolibrary.org/obo/HP_0025716		
HP:0001746	biolink:PhenotypicFeature	Asplenia	Absence (aplasia) of the spleen.	SNOMEDCT_US:93030006|SNOMEDCT_US:707147002|SNOMEDCT_US:702624008|Fyler:4771|UMLS:C0600031	hp.json	Absent spleen	http://purl.obolibrary.org/obo/HP_0001746		
HP:0025717	biolink:PhenotypicFeature	Skeletal muscle autophagosome accumulation	Abnormal accumulation of autophagosomes in skeletal muscle tissue.		hp.json	Autophagic material in muscle biopsy	http://purl.obolibrary.org/obo/HP_0025717		
UBERON:0035783	biolink:AnatomicalEntity	ganglion of ciliary nerve	Any parasympathetic ganglion that extends fibers into the short ciliary nerve. Includes both the main and acccessory ciliary ganglia.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035783		
HP:0025718	biolink:PhenotypicFeature	Skeletal muscle hyperechogenicity	An increased echo intensity of muscle tissue on sonography, defined as an increased amount of returning echoes per square area of muscle tissue. On cross-section, normal muscle appears as a relatively anechoic structure with hyperechoic speckles within the tissue representing perimysial septa, giving it a starry night appearance. The boundaries of each muscle are delineated by the presence of hyperechoic fascia. In muscle disorders, one of the hallmark findings is replacement of healthy muscle with fat and fibrosis, manifested by an increase in echogenicity from higher sound transitions in the muscle. This increase in echogenicity is most distinct in conditions that lead to chronic pathology, such as long-standing muscle inflammation, dystrophy, or denervation.		hp.json	Muscle ultrasound hyperechogenicity|Hyperechoic muscle	http://purl.obolibrary.org/obo/HP_0025718		
HP:0025719	biolink:PhenotypicFeature	Maternal vascular malperfusion	Gross findings of maternal vascular malperfusion include placental hypoplasia, placental infarction, and retroplacental hemorrhage. If information is available, it is preferable to annotate using the HPO terms that corresponding to the specific abnormalities.		hp.json		http://purl.obolibrary.org/obo/HP_0025719		
HP:0001743	biolink:PhenotypicFeature	Abnormality of the spleen	An abnormality of the spleen.	UMLS:C4025749	hp.json	Abnormality of the spleen	http://purl.obolibrary.org/obo/HP_0001743		
HP:0025710	biolink:PhenotypicFeature	Late young adult onset	Onset of disease at an age of greater than or equal to 25 to under 40 years.		hp.json		http://purl.obolibrary.org/obo/HP_0025710		
HP:0001744	biolink:PhenotypicFeature	Splenomegaly	Abnormal increased size of the spleen.	MSH:D013163|SNOMEDCT_US:16294009|UMLS:C0038002	hp.json	Increased spleen size	http://purl.obolibrary.org/obo/HP_0001744		
HP:0025711	biolink:PhenotypicFeature	Convergence-retraction nystagmus	Convergence-retraction nystagmus is an irregular, jerky nystagmus in which both eyeballs rhythmically converge and retract into the orbit, particularly on attempting an upward gaze.		hp.json	Convergence retraction nystagmus	http://purl.obolibrary.org/obo/HP_0025711		
HP:0001741	biolink:PhenotypicFeature	Phimosis	The male foreskin cannot be fully retracted from the head of the penis.	SNOMEDCT_US:253854008|UMLS:C0345326	hp.json		http://purl.obolibrary.org/obo/HP_0001741		
HP:0025712	biolink:PhenotypicFeature	Spontaneous chorioamniotic separation	Persistence separation of the chorionic and amnionic membranes after the 16th week of gestation (not as a result of a procedure such as amniocentesis).		hp.json		http://purl.obolibrary.org/obo/HP_0025712		
HP:0001742	biolink:PhenotypicFeature	Nasal congestion	Reduced ability to pass air through the nasal cavity often leading to mouth breathing.	UMLS:C0027424|MSH:D015508|SNOMEDCT_US:68235000|SNOMEDCT_US:267100006|SNOMEDCT_US:232209000|UMLS:C0027429	hp.json	Blockage of nose|Stuffy nose|Obstruction of nose|Nasal obstruction|Congestion of nose|Nasal blockage	http://purl.obolibrary.org/obo/HP_0001742		
HP:0025713	biolink:PhenotypicFeature	Neurite dystrophy	Dystrophic neurites are abnormal neuronal processes characterized microscopically by aberrant sprouting, dystrophic expansion, and accumulation of various cellular organelles and cytoskeletal/signaling proteins.		hp.json	Dystrophic neurite	http://purl.obolibrary.org/obo/HP_0025713		
NCBITaxon:314295	biolink:OrganismalEntity	Hominoidea			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_314295		
UBERON:0008192	biolink:AnatomicalEntity	tendon of triceps brachii	A tendon that attaches_to a triceps brachii.	FMA:38380	hp.json	tendon of triceps brachii muscle|triceps brachii tendon|triceps tendon	http://purl.obolibrary.org/obo/UBERON_0008192		
UBERON:0008193	biolink:AnatomicalEntity	pneumatized bone	A bone that is hollow or contains many air cells, such as the mastoid process of the temporal bone[TMD].	galen:PneumaticBone|FMA:7478|SCTID:333008005|Wikipedia:Skeletal_pneumaticity	hp.json	hollow bone|pneumatic bone|os pneumaticum	http://purl.obolibrary.org/obo/UBERON_0008193		
HP:0025703	biolink:PhenotypicFeature	Type 2 schizencephaly	A type of Schizencephaly in which CSF-containing cleft is present with abutting lining lips of abnormal grey matter that are opposed to each other.		hp.json		http://purl.obolibrary.org/obo/HP_0025703		
HP:0025704	biolink:PhenotypicFeature	Type 3 schizencephaly	A type of Schizencephaly in which CSF-containing cleft present with non-abutting lining lips of abnormal grey matter.		hp.json		http://purl.obolibrary.org/obo/HP_0025704		
HP:0001756	biolink:PhenotypicFeature	Vestibular hypofunction	Reduced functioning of the vestibular apparatus.	UMLS:C1848606	hp.json		http://purl.obolibrary.org/obo/HP_0001756		
HP:0025705	biolink:PhenotypicFeature	Abnormal fetal nasal bone visualization	Abnormal appearance or non-visualization (apparent absence) of the nasal bone of a fetus in first trimester sonographic screening. Assessment of the fetal nasal bone is generally performed at 11-14 weeks gestational age.		hp.json		http://purl.obolibrary.org/obo/HP_0025705		
HP:0001757	biolink:PhenotypicFeature	High-frequency sensorineural hearing impairment	A form of sensorineural hearing impairment that affects primarily the higher frequencies.	UMLS:C4021775	hp.json	High frequency sensorineural hearing impairment|High-tone sensorineural deafness|High-tone sensorineural hearing impairment	http://purl.obolibrary.org/obo/HP_0001757		
HP:0025706	biolink:PhenotypicFeature	Absent fetal nasal bone	The nasal bone is considered absent when it is not visualized on a midsagittal view of the profile. In the second trimester, a true midsagittal view of the fetal profile is obtained and magnified to fill the majority of the image space. The nasal bone appears as an echogenic linear structure below the skin edge. The optimal angle of insonation is 45 degrees to the longitudinal axis of the fetal nasal bone. If the angle of insonation is 0 or 180 degrees, the nasal bone may appear artificially absent. The presence or absence of the nasal bone may be determined at the time of the 11- to 14-week ultrasound examination and used as part of the risk assessment for aneuploidy.		hp.json	Absence of fetal nasal bone|Unossified nasal bone	http://purl.obolibrary.org/obo/HP_0025706		
HP:0025707	biolink:PhenotypicFeature	Hypoplastic nasal bone	Length of the nasal bone below a predetermined cut-off as seen on antenatal ultrasound using standard imaging techniques.		hp.json		http://purl.obolibrary.org/obo/HP_0025707		
HP:0025708	biolink:PhenotypicFeature	Early young adult onset	Onset of disease at an age of greater than or equal to 16 to under 19 years.		hp.json		http://purl.obolibrary.org/obo/HP_0025708		
HP:0025709	biolink:PhenotypicFeature	Intermediate young adult onset	Onset of disease at an age of greater than or equal to 19 to under 25 years.		hp.json		http://purl.obolibrary.org/obo/HP_0025709		
NCBITaxon:314293	biolink:OrganismalEntity	Simiiformes			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_314293		
HP:0001750	biolink:PhenotypicFeature	Single ventricle	The presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle.	Fyler:0200|SNOMEDCT_US:45503006|UMLS:C0152424|Fyler:200	hp.json	Common ventricle	http://purl.obolibrary.org/obo/HP_0001750		
HP:0001751	biolink:PhenotypicFeature	Vestibular dysfunction	An abnormality of the functioning of the vestibular apparatus.	UMLS:C1843865	hp.json	Impaired vestibular function|Interictal vestibular dysfunction|Vestibular function defect	http://purl.obolibrary.org/obo/HP_0001751		
HP:0410399	biolink:PhenotypicFeature	Positive blood lead test	Detection of lead in the blood.		hp.json	Increased blood lead level	http://purl.obolibrary.org/obo/HP_0410399		
HP:0025700	biolink:PhenotypicFeature	Anhydramnios	A complete or near-complete lack of amniotic fluid surrounding a fetus. This finding can be observed sonographically in the third trimesters if the deepest pocket of amniotic fluid is less than or equal to 2 cm.		hp.json		http://purl.obolibrary.org/obo/HP_0025700		
HP:0025701	biolink:PhenotypicFeature	Distended jugular lymphatic sacs	The jugular lymphatic sacs (JLS) are a physiological and temporary part of fetal lymphatic development. They are formed from small buds of lymphatic endothelial cells arising from the internal jugular veins. By 14 weeks gestation they have developed into lymphatic nodes which drain into the systemic circulation. Visibility of JLS on ultrasound past 14 weeks of gestation implies distension and this may be associated with raised nuchal translucency.		hp.json		http://purl.obolibrary.org/obo/HP_0025701		
HP:0025702	biolink:PhenotypicFeature	Type 1 schizencephaly	A type of Schizencephaly in which there is a trans-mantle column of abnormal grey matter but no evidence of a CSF-containing cleft on MR imaging.		hp.json	Trans-mantle schizencephaly	http://purl.obolibrary.org/obo/HP_0025702		
HP:0410393	biolink:PhenotypicFeature	Increased proportion of central memory CD4-positive, alpha-beta T cells	An abnormally elevated proportion of central memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json	Elevated proportion of CD4+ central memory cells|Increased proportion of CD4+ central memory cells|Increased proportion of central memory CD4+, alpha-beta T cell|Elevated proportion central memory CD4-positive, alpha-beta T cells	http://purl.obolibrary.org/obo/HP_0410393		
UBERON:0008196	biolink:AnatomicalEntity	muscle of pectoral girdle	Any muscle organ that is part of a pectoral girdle region.	FMA:37347|EMAPA:17748	hp.json	muscle of shoulder girdle|pectoral girdle muscle	http://purl.obolibrary.org/obo/UBERON_0008196		pheno_slim
HP:0410392	biolink:PhenotypicFeature	Increased proportion of CD8-positive, alpha-beta memory T cells	An abnormally elevated proportion of CD8-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RO and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.		hp.json		http://purl.obolibrary.org/obo/HP_0410392		
UBERON:0008198	biolink:AnatomicalEntity	nail plate	The nail plate is the hard and translucent portion of the nail, composed of keratin.	EMAPA:35583|NCIT:C34216|MA:0002708	hp.json	lamina unguis	http://purl.obolibrary.org/obo/UBERON_0008198		human_reference_atlas
HP:0410391	biolink:PhenotypicFeature	Increased proportion of CD4-positive, alpha-beta memory T cells	An abnormally elevated proportion of CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype of CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative, CD44-high, and CD122-high.		hp.json		http://purl.obolibrary.org/obo/HP_0410391		
UBERON:0008199	biolink:AnatomicalEntity	chin	A subdivision of the face that is the anteriormost part of the lower jaw region.	MESH:D002680|NCIT:C81169|EMAPA:37827|FMA:46495|galen:Chin|TAO:0002254|GAID:67	hp.json	mental region of face|mental part of face|regio mentalis|mental region|mentum	http://purl.obolibrary.org/obo/UBERON_0008199		pheno_slim
HP:0410390	biolink:PhenotypicFeature	Decreased proportion of effector memory CD8-positive, alpha-beta T cells	A reduced proportion of CD8-positive, alpha-beta effector memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json		http://purl.obolibrary.org/obo/HP_0410390		
HP:0410397	biolink:PhenotypicFeature	Bronchiolectasis	Saccular dilatation of the terminal bronchioles.		hp.json	Bronchiolectasia	http://purl.obolibrary.org/obo/HP_0410397		
HP:0410396	biolink:PhenotypicFeature	Increased proportion of central memory CD8-positive, alpha-beta T cells	An increased proportion of central memory CD8-positive, alpha-beta T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json		http://purl.obolibrary.org/obo/HP_0410396		
HP:0410395	biolink:PhenotypicFeature	Increased proportion of effector memory CD8-positive, alpha-beta T cells	An increased proportion of effector memory CD8-positive, alpha-beta T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json		http://purl.obolibrary.org/obo/HP_0410395		
HP:0410394	biolink:PhenotypicFeature	Increased proportion of effector memory CD4-positive, alpha-beta T cells	An abnormally elevated proportion of effector memory CD4-positive, alpha-beta memory T cells compared to the total number of T cells in the blood. These cells have the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json		http://purl.obolibrary.org/obo/HP_0410394		
GO:0051355	biolink:NamedThing	proprioception involved in equilibrioception			hp.json		http://purl.obolibrary.org/obo/GO_0051355		
GO:0051356	biolink:BiologicalProcess	visual perception involved in equilibrioception	The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity.		hp.json	equilibrioception by visual perception|visual perception during equilibrioception|perception of orientation with respect to gravity by visual perception	http://purl.obolibrary.org/obo/GO_0051356		
GO:1905770	biolink:BiologicalProcess	regulation of mesodermal cell differentiation	Any process that modulates the frequency, rate or extent of mesodermal cell differentiation.		hp.json	regulation of mesoderm cell differentiation	http://purl.obolibrary.org/obo/GO_1905770		
GO:1905771	biolink:BiologicalProcess	negative regulation of mesodermal cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of mesodermal cell differentiation.		hp.json	down-regulation of mesoderm cell differentiation|negative regulation of mesoderm cell differentiation|downregulation of mesodermal cell differentiation|inhibition of mesodermal cell differentiation|down regulation of mesoderm cell differentiation|downregulation of mesoderm cell differentiation|inhibition of mesoderm cell differentiation|down-regulation of mesodermal cell differentiation|down regulation of mesodermal cell differentiation	http://purl.obolibrary.org/obo/GO_1905771		
GO:1905772	biolink:BiologicalProcess	positive regulation of mesodermal cell differentiation	Any process that activates or increases the frequency, rate or extent of mesodermal cell differentiation.		hp.json	upregulation of mesoderm cell differentiation|up-regulation of mesodermal cell differentiation|up regulation of mesodermal cell differentiation|activation of mesodermal cell differentiation|up-regulation of mesoderm cell differentiation|up regulation of mesoderm cell differentiation|activation of mesoderm cell differentiation|upregulation of mesodermal cell differentiation|positive regulation of mesoderm cell differentiation	http://purl.obolibrary.org/obo/GO_1905772		
PR:000050032	biolink:Protein	immunoglobulin complex (human)	An immunoglobulin complex whose components are encoded in the genome of human.		hp.json	hIg	http://purl.obolibrary.org/obo/PR_000050032		
UBERON:0011745	biolink:AnatomicalEntity	pulmonary valve leaflets	A cardiac valve leaflet that is part of a pulmonary valve.	EMAPA:18629|VHOG:0000820	hp.json		http://purl.obolibrary.org/obo/UBERON_0011745		pheno_slim
IAO:0000116	biolink:NamedThing	editor note		IAO:0000116	hp.json		http://purl.obolibrary.org/obo/IAO_0000116		
GO:0051350	biolink:BiologicalProcess	negative regulation of lyase activity	Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.		hp.json	down-regulation of lyase activity|lyase inhibitor|downregulation of lyase activity|down regulation of lyase activity|inhibition of lyase activity	http://purl.obolibrary.org/obo/GO_0051350		
IAO:0000115	biolink:NamedThing	definition			hp.json		http://purl.obolibrary.org/obo/IAO_0000115		
GO:0051353	biolink:BiologicalProcess	positive regulation of oxidoreductase activity	Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.		hp.json	oxidoreductase activator|up-regulation of oxidoreductase activity|up regulation of oxidoreductase activity|activation of oxidoreductase activity|ribonucleotide reductase activating enzyme activity|stimulation of oxidoreductase activity|upregulation of oxidoreductase activity	http://purl.obolibrary.org/obo/GO_0051353		
GO:0051354	biolink:BiologicalProcess	negative regulation of oxidoreductase activity	Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered.		hp.json	inhibition of oxidoreductase activity|downregulation of oxidoreductase activity|down-regulation of oxidoreductase activity|oxidoreductase inhibitor|down regulation of oxidoreductase activity	http://purl.obolibrary.org/obo/GO_0051354		
GO:0051351	biolink:BiologicalProcess	positive regulation of ligase activity	Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.		hp.json	up-regulation of ligase activity|up regulation of ligase activity|ligase activator|activation of ligase activity|stimulation of ligase activity|upregulation of ligase activity	http://purl.obolibrary.org/obo/GO_0051351		
GO:0051352	biolink:BiologicalProcess	negative regulation of ligase activity	Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.		hp.json	down-regulation of ligase activity|down regulation of ligase activity|ligase inhibitor|inhibition of ligase activity|downregulation of ligase activity	http://purl.obolibrary.org/obo/GO_0051352		
GO:1903119	biolink:BiologicalProcess	protein localization to actin cytoskeleton	A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton.		hp.json	protein localisation in actin cytoskeleton|protein localisation to actin cytoskeleton|protein localization in actin cytoskeleton	http://purl.obolibrary.org/obo/GO_1903119		
UBERON:0011742	biolink:AnatomicalEntity	aortic valve leaflet	A cardiac valve leaflet that is part of a aortic valve.	EMAPA:18627|VHOG:0000819	hp.json	aortic valve leaflets	http://purl.obolibrary.org/obo/UBERON_0011742		pheno_slim
UBERON:0011741	biolink:AnatomicalEntity	cardiac valve leaflet		EMAPA:35903|MA:0003179	hp.json	valve leaflet	http://purl.obolibrary.org/obo/UBERON_0011741		
GO:0051378	biolink:MolecularActivity	serotonin binding	Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.		hp.json	5-hydroxytryptamine binding	http://purl.obolibrary.org/obo/GO_0051378		
GO:1903133	biolink:BiologicalProcess	negative regulation of tube lumen cavitation	Any process that stops, prevents or reduces the frequency, rate or extent of tube lumen cavitation.		hp.json	inhibition of tube lumen cavitation	http://purl.obolibrary.org/obo/GO_1903133		
GO:1903132	biolink:BiologicalProcess	regulation of tube lumen cavitation	Any process that modulates the frequency, rate or extent of tube lumen cavitation.		hp.json		http://purl.obolibrary.org/obo/GO_1903132		
GO:1903131	biolink:BiologicalProcess	mononuclear cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a mononuclear cell.		hp.json		http://purl.obolibrary.org/obo/GO_1903131		
PR:000050060	biolink:Protein	glucose-6-phosphate dehydrogenase	A protein that contains a single copy of the Glucose-6-phosphate dehydrogenase, NAD binding domain (Pfam:PF00479) at or near the N terminus, a single copy of the Glucose-6-phosphate dehydrogenase, C-terminal domain (Pfam:PF02781) at or near the C terminus, and no other domains.		hp.json	fam:G6PD	http://purl.obolibrary.org/obo/PR_000050060		
GO:0051380	biolink:MolecularActivity	norepinephrine binding	Binding to norepinephrine, (3,4-dihydroxyphenyl-2-aminoethanol), a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.		hp.json	noradrenaline binding	http://purl.obolibrary.org/obo/GO_0051380		
GO:2000700	biolink:BiologicalProcess	positive regulation of cardiac muscle cell myoblast differentiation	Any process that activates or increases the frequency, rate or extent of cardiac muscle cell myoblast differentiation.		hp.json	positive regulation of cardiac myoblast differentiation|positive regulation of myocardial precursor cell differentiation	http://purl.obolibrary.org/obo/GO_2000700		
UBERON:0011779	biolink:AnatomicalEntity	nerve of head region	A nerve that is part of a head.		hp.json	head nerve|cephalic nerve	http://purl.obolibrary.org/obo/UBERON_0011779		grouping_class
CHEBI:16526	biolink:ChemicalSubstance	carbon dioxide	A one-carbon compound with formula CO2 in which the carbon is attached to each oxygen atom by a double bond. A colourless, odourless gas under normal conditions, it is produced during respiration by all animals, fungi and microorganisms that depend directly or indirectly on living or decaying plants for food.	MolBase:752|PMID:23828359|PMID:14639145|PMID:11802652|UM-BBD_compID:c0131|CAS:124-38-9|PMID:9611769|PMID:8869828|Gmelin:989|PMID:19259576|PMID:10826146|PDBeChem:CO2|CAS:124-38-9|KEGG:D00004|CAS:124-38-9|HMDB:HMDB0001967|Drug_Central:4256|PMID:19854893|MetaCyc:CARBON-DIOXIDE|PMID:16656478|Wikipedia:Carbon_dioxide|PMID:8482095|PPDB:119|PMID:17190796|KEGG:C00011|PMID:19043767|PMID:17448243|PMID:17884085|PMID:9730350|Beilstein:1900390|Reaxys:1900390|PMID:8818713|PMID:15050588|PMID:17878298|PMID:11094503|PMID:23384758|PMID:11584085|PMID:16591971|PMID:16659660|PMID:24258718	hp.json	E 290|[CO2]|carbonic anhydride|CO2|R-744|carbon dioxide|methanedione|CO2|Carbon dioxide|dioxidocarbon|E290|CARBON DIOXIDE|E-290	http://purl.obolibrary.org/obo/CHEBI_16526		3_STAR
UBERON:0011777	biolink:AnatomicalEntity	nucleus of spinal cord	A neural nucleus that is part of the spinal cord.	FMA:77011	hp.json	spinal cord nucleus	http://purl.obolibrary.org/obo/UBERON_0011777		grouping_class
UBERON:0011775	biolink:AnatomicalEntity	vagus nerve nucleus	A cranial nerve nucleus that is associated with a vagus nerve.	SCTID:362467005|FMA:54573	hp.json	nucleus of Xth nerve|nucleus of vagus nerve|vagal X nucleus|vagal X nucleus|nodosal nucleus|nodosal nucleus|tenth cranial nerve nucleus|nucleus of vagal nerve|vagus nucleus|vagus nucleus|vagal nucleus|vagal nucleus|nucleus of vagal X nerve	http://purl.obolibrary.org/obo/UBERON_0011775		
GO:2000725	biolink:BiologicalProcess	regulation of cardiac muscle cell differentiation	Any process that modulates the frequency, rate or extent of cardiac muscle cell differentiation.		hp.json	regulation of cardiomyocyte differentiation|regulation of heart muscle cell differentiation	http://purl.obolibrary.org/obo/GO_2000725		
UBERON:0011773	biolink:AnatomicalEntity	upper jaw opening	An anatomical space that is part of a bone of upper jaw.	AAO:0000621	hp.json		http://purl.obolibrary.org/obo/UBERON_0011773		
GO:2000726	biolink:BiologicalProcess	negative regulation of cardiac muscle cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell differentiation.		hp.json	negative regulation of cardiomyocyte differentiation|negative regulation of heart muscle cell differentiation	http://purl.obolibrary.org/obo/GO_2000726		
UBERON:0011772	biolink:AnatomicalEntity	lower jaw opening	An anatomical space that is part of a bone of lower jaw.	AAO:0000273	hp.json		http://purl.obolibrary.org/obo/UBERON_0011772		
GO:2000727	biolink:BiologicalProcess	positive regulation of cardiac muscle cell differentiation	Any process that activates or increases the frequency, rate or extent of cardiac muscle cell differentiation.		hp.json	positive regulation of cardiomyocyte differentiation|positive regulation of heart muscle cell differentiation	http://purl.obolibrary.org/obo/GO_2000727		
UBERON:0011767	biolink:AnatomicalEntity	right recurrent laryngeal nerve		EMAPA:17275|FMA:14468|MA:0001108|SCTID:280299003	hp.json	right recurrent laryngeal branch|vagus X nerve right recurrent laryngeal branch|right recurrent laryngeal nerve	http://purl.obolibrary.org/obo/UBERON_0011767		
UBERON:0011766	biolink:AnatomicalEntity	left recurrent laryngeal nerve		EMAPA:25350|FMA:14469|SCTID:280300006|MA:0001107	hp.json	vagus X nerve left recurrent laryngeal branch|left recurrent laryngeal branch|left recurrent laryngeal nerve	http://purl.obolibrary.org/obo/UBERON_0011766		
UBERON:0011769	biolink:AnatomicalEntity	cartilaginous projection	Anatomical projection that is composed of cartilage tissue.	FMA:284626	hp.json	cartilaginous process|cartilage process	http://purl.obolibrary.org/obo/UBERON_0011769		
GO:2000736	biolink:BiologicalProcess	regulation of stem cell differentiation	Any process that modulates the frequency, rate or extent of stem cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2000736		
GO:1903179	biolink:BiologicalProcess	regulation of dopamine biosynthetic process	Any process that modulates the frequency, rate or extent of dopamine biosynthetic process.		hp.json	regulation of dopamine formation|regulation of dopamine anabolism|regulation of dopamine biosynthesis|regulation of dopamine synthesis	http://purl.obolibrary.org/obo/GO_1903179		
GO:2000737	biolink:BiologicalProcess	negative regulation of stem cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of stem cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2000737		
GO:2000738	biolink:BiologicalProcess	positive regulation of stem cell differentiation	Any process that activates or increases the frequency, rate or extent of stem cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2000738		
UBERON:0011757	biolink:AnatomicalEntity	differentiated genital tubercle		UMLS:C1514448|NCIT:C34274	hp.json	phallus|primordial phallus|phallus primordialis	http://purl.obolibrary.org/obo/UBERON_0011757		
UBERON:0011756	biolink:AnatomicalEntity	male genital swelling	A genital swelling that is part of a male reproductive organ.	EHDAA2:0001049|EMAPA:30509	hp.json	labioscrotal swelling of male|scrotal bulge|scrotal primordium	http://purl.obolibrary.org/obo/UBERON_0011756		
UBERON:0011755	biolink:AnatomicalEntity	female labial swelling	A genital swelling that is part of a female reproductive system.	EHDAA2:0000501|EMAPA:30423|EMAPA:18329|EHDAA:9363	hp.json	labial swelling|labial primordium|labioscrotal swelling of female	http://purl.obolibrary.org/obo/UBERON_0011755		
UBERON:0011754	biolink:AnatomicalEntity	genital swelling	Paired structures in the embryo that represent the final stage of development of the caudal end of the external genitals before sexual differentiation. In both males and females the two swellings merge: in the female, they become the posterior labial commissure; In the male, they become the scrotum.	VHOG:0000976|EMAPA:35377|EMAPA:30074	hp.json	tuberculum labioscrotale|labioscrotal swelling	http://purl.obolibrary.org/obo/UBERON_0011754		
GO:1903181	biolink:BiologicalProcess	positive regulation of dopamine biosynthetic process	Any process that activates or increases the frequency, rate or extent of dopamine biosynthetic process.		hp.json	upregulation of dopamine biosynthetic process|up regulation of dopamine anabolism|upregulation of dopamine biosynthesis|upregulation of dopamine formation|positive regulation of dopamine synthesis|up-regulation of dopamine anabolism|activation of dopamine anabolism|up regulation of dopamine synthesis|positive regulation of dopamine formation|up-regulation of dopamine biosynthesis|up-regulation of dopamine biosynthetic process|up-regulation of dopamine synthesis|up regulation of dopamine formation|activation of dopamine synthesis|up regulation of dopamine biosynthesis|upregulation of dopamine anabolism|up regulation of dopamine biosynthetic process|up-regulation of dopamine formation|activation of dopamine formation|positive regulation of dopamine biosynthesis|activation of dopamine biosynthetic process|activation of dopamine biosynthesis|upregulation of dopamine synthesis|positive regulation of dopamine anabolism	http://purl.obolibrary.org/obo/GO_1903181		
GO:1903180	biolink:BiologicalProcess	negative regulation of dopamine biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of dopamine biosynthetic process.		hp.json	negative regulation of dopamine formation|down-regulation of dopamine formation|down regulation of dopamine biosynthetic process|down regulation of dopamine biosynthesis|downregulation of dopamine anabolism|inhibition of dopamine biosynthetic process|inhibition of dopamine biosynthesis|down regulation of dopamine anabolism|downregulation of dopamine biosynthesis|downregulation of dopamine biosynthetic process|downregulation of dopamine synthesis|inhibition of dopamine anabolism|negative regulation of dopamine anabolism|down-regulation of dopamine anabolism|downregulation of dopamine formation|down regulation of dopamine synthesis|inhibition of dopamine synthesis|negative regulation of dopamine synthesis|down regulation of dopamine formation|down-regulation of dopamine synthesis|negative regulation of dopamine biosynthesis|inhibition of dopamine formation|down-regulation of dopamine biosynthetic process|down-regulation of dopamine biosynthesis	http://purl.obolibrary.org/obo/GO_1903180		
CHEBI:16541	biolink:ChemicalSubstance	protein polypeptide chain	A naturally occurring polypeptide synthesized at the ribosome.	KEGG:C00017	hp.json	Protein|protein polypeptide chains|polypeptide chain|a protein	http://purl.obolibrary.org/obo/CHEBI_16541		3_STAR
PR:000050025	biolink:Protein	angiotensinogenase	A protein that is a translation product of the mouse Ren1 or Ren2 genes, 1:1 orthologs thereof, or a semi-ortholog thereof.		hp.json	fam:angiotensinogenase	http://purl.obolibrary.org/obo/PR_000050025		
UBERON:0008114	biolink:AnatomicalEntity	joint of girdle	A skeletal joint that is part of a appendage girdle region.	MA:0001505	hp.json	girdle joint	http://purl.obolibrary.org/obo/UBERON_0008114		grouping_class
UBERON:0008115	biolink:AnatomicalEntity	surface of cartilage	An anatomical surface that is part of a cartilage element.	FMA:76668	hp.json	cartilage surface	http://purl.obolibrary.org/obo/UBERON_0008115		
HP:0011098	biolink:PhenotypicFeature	Speech apraxia	A type of apraxia that is characterized by difficulty or inability to execute speech movements because of problems with coordination and motor problems, leading to incorrect articulation. An increase of errors with increasing word and phrase length may occur.	UMLS:C0264611|SNOMEDCT_US:361277007|UMLS:C0349391|SNOMEDCT_US:361276003|MSH:D001072|SNOMEDCT_US:74227009	hp.json	Apraxia of speech|Speech dyspraxia|Verbal dyspraxia	http://purl.obolibrary.org/obo/HP_0011098		
HP:0011099	biolink:PhenotypicFeature	Spastic hemiparesis	Unilateral paresis (weakness) with spasticity of the affected muscles and increased tendon reflexes.	MSH:D006429|SNOMEDCT_US:79633009|UMLS:C0154694	hp.json	Spastic hemiplegia	http://purl.obolibrary.org/obo/HP_0011099		
HP:0011090	biolink:PhenotypicFeature	Fused teeth	The union of two separately developing tooth germs typically leading to one less tooth than normal in the affected dental arch.	SNOMEDCT_US:1744008|MSH:D005671|UMLS:C0016873	hp.json	Joined teeth|Fusion of teeth|Fused teeth	http://purl.obolibrary.org/obo/HP_0011090		hposlim_core
HP:0011091	biolink:PhenotypicFeature	Gemination	The development of two teeth from a single tooth bud, leading to a larger fused tooth.	SNOMEDCT_US:40273006|UMLS:C0266033	hp.json	Splitting of crown of tooth|Gemination of tooth	http://purl.obolibrary.org/obo/HP_0011091		
HP:0011092	biolink:PhenotypicFeature	Mulberry molar	Mulberry molars are irregular teeth generally affecting the first molars and are characterized by a grossly deformed crown imitating, as the name implies, the surface of a mulberry.	SNOMEDCT_US:109436001|UMLS:C0266024	hp.json	Syphilitic permanent first molar	http://purl.obolibrary.org/obo/HP_0011092		
HP:0011093	biolink:PhenotypicFeature	Molarization of premolar	Increased size and molar morphology of premolar tooth.	UMLS:C1404304|UMLS:C4280334	hp.json	Molar shape of bicuspid|Molarization of bicuspid|Enlarged premolar|Molar shape of premolar|Increased size of premolar	http://purl.obolibrary.org/obo/HP_0011093		
HP:0011094	biolink:PhenotypicFeature	Increased overbite	Maxillary teeth cover the mandibular teeth when biting to an increased degree. The feature is defined as a vertical overlap of the maxillary incisors over the mandibular incisors that exceeds 2 mm.	MSH:D057887|SNOMEDCT_US:10816007|SNOMEDCT_US:251293001|UMLS:C0266067|UMLS:C1305740|UMLS:C0266063|SNOMEDCT_US:63783001|SNOMEDCT_US:60476005	hp.json	Overbite|Supraocclusion|Scissors bite|Deep overbite|Deep bite|Increased overlap of upper and lower incisors	http://purl.obolibrary.org/obo/HP_0011094		
HP:0011095	biolink:PhenotypicFeature	Overjet	An abnormal anteroposterior extension of the maxillary teeth beyond the plane of the mandibular teeth upon jaw closure.	MSH:D057887|UMLS:C0596028|SNOMEDCT_US:70305005|SNOMEDCT_US:251292006	hp.json	Protrusion of the maxillary incisors|Upper teeth sticking out forward|Protrusion of upper teeth in front of lower teeth|Buck teeth|Abnormality of horizontal incisor relationship	http://purl.obolibrary.org/obo/HP_0011095		
HP:0011096	biolink:PhenotypicFeature	Peripheral demyelination	A loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.	UMLS:C0878575	hp.json	Demyelination	http://purl.obolibrary.org/obo/HP_0011096		
HP:0011097	biolink:PhenotypicFeature	Epileptic spasm	A sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. Limited forms may occur: Grimacing, head nodding, or subtle eye movements. Epileptic spasms frequently occur in clusters. Infantile spasms are the best known form, but spasms can occur at all ages	UMLS:C1527366|SNOMEDCT_US:28055006|UMLS:C0037769|MSH:D013036	hp.json	Salaam seizure|Epileptic spasms|Salaam seizures|Salaam convulsion|West syndrome|Salaam convulsions	http://purl.obolibrary.org/obo/HP_0011097		
PR:000001020	biolink:Protein	CD3 epsilon	A CD3 subunit with immunoglobulin domain that is a translation product of the human CD3E gene or a 1:1 ortholog thereof.	IUPHARobj:2742	hp.json	T3E|T-cell surface antigen T3/Leu-4 epsilon chain|CD3E|CD3e	http://purl.obolibrary.org/obo/PR_000001020		
PR:000001023	biolink:Protein	neural cell adhesion molecule NCAM	A neural cell adhesion molecule that is involved in neuronal development, synaptic plasticity, and regeneration.	PIRSF:PIRSF501037	hp.json		http://purl.obolibrary.org/obo/PR_000001023		
PR:000001022	biolink:Protein	neural cell adhesion molecule	A protein with a domain composition consisting of a large extracellular domain, including five Ig-like C2-type domains followed by two copies of the Fibronectin type-III domain (Pfam:PF00041), a single-pass transmembrane domain and a short cytoplasmic C-terminal domain.	PIRSF:PIRSF002507	hp.json		http://purl.obolibrary.org/obo/PR_000001022		
CHEBI:77450	biolink:ChemicalSubstance	dicarboxylic acid monoamide(1-)	A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any dicarboxylic acid monoamide; major species at pH 7.3.	MetaCyc:DICARBOXYLIC-ACID-MONOAMIDES	hp.json	a monoamide of a dicarboxylate	http://purl.obolibrary.org/obo/CHEBI_77450		3_STAR
PR:000001024	biolink:Protein	neural cell adhesion molecule 1	A neural cell adhesion molecule NCAM that is a translation product of the human NCAM1 gene or a 1:1 ortholog thereof.	IUPHARobj:2769	hp.json	NCAM|NCAM-1|N-CAM-1|CD56|NCAM1	http://purl.obolibrary.org/obo/PR_000001024		
HP:0011087	biolink:PhenotypicFeature	Talon cusp	Talon cusp is an accessory cusp located near the cingulum (the portion of the lingual or palatal aspect of the tooth that forms a convex protuberance at the cervical third of the anatomic crown).	UMLS:C0399357|SNOMEDCT_US:63691004|SNOMEDCT_US:234955005|UMLS:C4280335|UMLS:C0266034	hp.json	Talon cusps|Dens evaginatus|Extra cusp on inside of front tooth	http://purl.obolibrary.org/obo/HP_0011087		hposlim_core
HP:0011088	biolink:PhenotypicFeature	Dens in dente	An abnormality of the incisor characterized by invagination of the enamel, giving a radiographic appearance that suggests a tooth within a tooth.	UMLS:C0011320|MSH:D003719|SNOMEDCT_US:55197001	hp.json	Tooth within a tooth|Dens invaginatus	http://purl.obolibrary.org/obo/HP_0011088		
HP:0011089	biolink:PhenotypicFeature	Double tooth	Fusion of two adjacent teeth.	SNOMEDCT_US:1744008|MSH:D005671|UMLS:C0016873	hp.json	Twinning tooth|Double tooth|Teeth, double|Conjoined teeth	http://purl.obolibrary.org/obo/HP_0011089		
HP:0011080	biolink:PhenotypicFeature	Abnormal premolar morphology	An abnormality of morphology of premolar tooth.	UMLS:C4023545	hp.json	Abnormality of shape of premolar|Abnormality of shape of bicuspid|Abnormality of bicuspid morphology|Abnormality of premolar morphology	http://purl.obolibrary.org/obo/HP_0011080		
HP:0011081	biolink:PhenotypicFeature	Incisor macrodontia	Increased size of the incisor tooth.	UMLS:C4023544|UMLS:C4280337	hp.json	Large incisor|Increased width of incisor|Increased size of incisor|Hyperplasia of incisor|Hypertrophy of incisor	http://purl.obolibrary.org/obo/HP_0011081		
GO:0002351	biolink:BiologicalProcess	serotonin production involved in inflammatory response	The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.		hp.json	serotonin production involved in acute inflammatory response	http://purl.obolibrary.org/obo/GO_0002351		
HP:0011082	biolink:PhenotypicFeature	Conical primary incisor	An abnormal conical morphology of the primary incisor.	UMLS:C4023543	hp.json	Primary front shark tooth|Conical deciduous incisor|Peg shaped primary incisor|Conoid primary incisor|Pointed primary incisor|Cone shaped front baby tooth|Pointed front baby tooth|Peg shaped front baby tooth	http://purl.obolibrary.org/obo/HP_0011082		
HP:0011083	biolink:PhenotypicFeature	Conical maxillary incisor	An abnormal conical morphology of either maxillary primary incisor tooth or maxillary permanent incisor tooth or both.	UMLS:C4023542	hp.json	Pointed maxillary incisor|Conoid maxillary incisor|Upper front shark tooth|Cone shaped upper front tooth|Cone shaped maxillary incisor|Peg shaped upper front tooth|Pointed upper front tooth	http://purl.obolibrary.org/obo/HP_0011083		
HP:0011084	biolink:PhenotypicFeature	Hypocalcification of dental enamel	A form of hypomineralization of enamel characterized by reduced calcification.	UMLS:C4023541	hp.json	Decreased enamel calcification|Poorly calcified tooth enamel	http://purl.obolibrary.org/obo/HP_0011084		
HP:0011085	biolink:PhenotypicFeature	Hypomature dental enamel	A form of hypomineralization of enamel characterized by a chalky appearance of the enamel with orange, brown, or white color.	UMLS:C4023540|UMLS:C4280336|UMLS:C4280266	hp.json	Immature tooth enamel|Soft teeth|Soft tooth enamel	http://purl.obolibrary.org/obo/HP_0011085		
HP:0011086	biolink:PhenotypicFeature	Dentinogenesis imperfecta of primary and permanent teeth	Developmental dysplasia of dentin or both the primary dentition and the permanent dentition.	UMLS:C4023539	hp.json	Dentinogenesis imperfecta of both sets of teeth|Dentinogenesis imperfecta of adult and baby teeth	http://purl.obolibrary.org/obo/HP_0011086		
HP:0011076	biolink:PhenotypicFeature	Abnormality of premolar	An abnormality of premolar tooth.	UMLS:C4023548	hp.json	Abnormality of premolar|Abnormality of bicuspid	http://purl.obolibrary.org/obo/HP_0011076		
HP:0011077	biolink:PhenotypicFeature	Abnormality of molar	An abnormality of molar tooth.	UMLS:C4023547	hp.json	Abnormality of molar	http://purl.obolibrary.org/obo/HP_0011077		
HP:0011078	biolink:PhenotypicFeature	Abnormality of canine	An abnormality of canine tooth.	UMLS:C4023546	hp.json	Abnormality of canine|Abnormality of eye tooth	http://purl.obolibrary.org/obo/HP_0011078		
HP:0011079	biolink:PhenotypicFeature	Impacted tooth	A tooth that has not erupted because of local impediments (overcrowding or fibrous gum overgrowth).	MSH:D014095|UMLS:C0040456|SNOMEDCT_US:235104008|SNOMEDCT_US:129263008|UMLS:C4280338	hp.json	Impacted tooth|Buried tooth|Retained tooth	http://purl.obolibrary.org/obo/HP_0011079		hposlim_core
GO:0002320	biolink:BiologicalProcess	lymphoid progenitor cell differentiation	The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.		hp.json		http://purl.obolibrary.org/obo/GO_0002320		
GO:0002322	biolink:BiologicalProcess	B cell proliferation involved in immune response	The expansion of a B cell population by cell division following B cell activation during an immune response.		hp.json	B-lymphocyte proliferation during immune response|B cell proliferation during immune response|B lymphocyte proliferation during immune response|B-cell proliferation during immune response	http://purl.obolibrary.org/obo/GO_0002322		
OBO:HsapDv_0000204	biolink:NamedThing	mature stage	Human developmental stage that refers to a sexually mature human.	UBERON:0000113	hp.json		http://purl.obolibrary.org/obo/HsapDv_0000204		
HP:0011070	biolink:PhenotypicFeature	Abnormal molar morphology	An abnormality of morphology of molar tooth.	UMLS:C4023553	hp.json	Abnormality of molar morphology|Abnormal shape of molar tooth	http://purl.obolibrary.org/obo/HP_0011070		
HP:0011071	biolink:PhenotypicFeature	Abnormality of permanent molar morphology	An abnormality of morphology of permanent molar.	UMLS:C4023552	hp.json	Abnormality of shape of adult molar|Abnormality of shape of permanent molar	http://purl.obolibrary.org/obo/HP_0011071		
HP:0011072	biolink:PhenotypicFeature	Rootless teeth		UMLS:C4082200|SNOMEDCT_US:109493006|UMLS:C0399379|MSH:C538215	hp.json	Agenesis of tooth root|Aplasia of tooth root|Missing tooth root|Rootless teeth|Teeth without roots|Absence of tooth root|Tooth with dentin dysplasia type i	http://purl.obolibrary.org/obo/HP_0011072		
HP:0011073	biolink:PhenotypicFeature	Abnormality of dental color	A developmental defect of tooth color.	UMLS:C4023551	hp.json	Abnormality of tooth colour|Abnormality of tooth color|Abnormality of tooth shade|Abnormality of dental colour|Abnormality of dental color|Abnormality of dental shade	http://purl.obolibrary.org/obo/HP_0011073		
HP:0011074	biolink:PhenotypicFeature	Localized hypoplasia of dental enamel	A localized form of developmental hypoplasia of the dental enamel.	UMLS:C4023550|UMLS:C4280339	hp.json	Localized hypoplasia of tooth enamel|Localized dysplasia of tooth enamel|Localised dysplasia of tooth enamel|Localised hypoplasia of tooth enamel|Localised hypoplasia of dental enamel	http://purl.obolibrary.org/obo/HP_0011074		
HP:0011075	biolink:PhenotypicFeature	Green teeth	A green staining of teeth.	UMLS:C4023549	hp.json	Green colored teeth|Green tooth shade|Green teeth|Green coloured teeth	http://purl.obolibrary.org/obo/HP_0011075		
PR:000001003	biolink:Protein	CD34 molecule	A protein that is a translation product of the human CD34 gene or a 1:1 ortholog thereof. It is a leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. It contains a single-pass transmembrane domain and that show distinct expression on early hematopoietic precursors and vascular-associated tissue. Acts as a scaffold that presents selectin carbohydrate ligands in a clustered, tissue specific manner to allow for higher avidity interactions between leukocytes and endothelial cells during the inflammatory process. In common with related sialomucins (endoglycan and podocalyxin), the extracellular region is dominated by an N-terminal mucin-like domain, which is densely substituted with sialylated O-linked carbohydrates. The mucin-like region is followed by a cysteine-containing and presumably globular domain. This domain may fold into an immunoglobulin-like structure as the positions of 2 of the cysteines are conserved in the C2 set of the immunoglobulin superfamily. The cytoplasmic domain is around 73-76 residues long and highly conserved.	PIRSF:PIRSF028749	hp.json	hematopoietic progenitor cell antigen CD34|CD34	http://purl.obolibrary.org/obo/PR_000001003		
PR:000001002	biolink:Protein	CD19 molecule	A protein that is a translation product of the human CD19 gene or a 1:1 ortholog thereof. It is composed of an N-terminal extracellular domain containing two Ig-like C2-type (immunoglobulin-like) domains, followed by a single-pass transmembrane segment and a cytoplasmic C-terminal tail. CD19 expression is restricted to members of the B cell lineage. It functions as a co-receptor for B-cell antigen receptor (BCR), regulating signal transduction.	PIRSF:PIRSF016630|IUPHARobj:2764	hp.json	B-lymphocyte surface antigen B4|T-cell surface antigen Leu-12|CD19|differentiation antigen CD19	http://purl.obolibrary.org/obo/PR_000001002		
PR:000001005	biolink:Protein	integrin alpha with A domain	An integrin alpha that contains an A domain. A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. Unlike other integrin alpha proteins, they do not undergo proteolytic cleavage.	PIRSF:PIRSF002497	hp.json	integrin alpha with I domain	http://purl.obolibrary.org/obo/PR_000001005		
PR:000001004	biolink:Protein	CD4 molecule	A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence.	PIRSF:PIRSF001977	hp.json	T-cell surface glycoprotein CD4|T-cell surface antigen T4/Leu-3|T-cell differentiation antigen L3T4|CD4	http://purl.obolibrary.org/obo/PR_000001004		
PR:000001006	biolink:Protein	receptor-type tyrosine-protein phosphatase C	A protein that is a translation product of the human PTPRC gene or a 1:1 ortholog thereof. It is composed of an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic protein-tyrosine phosphatase domains. Contains 1 to 3 copies of the Fibronectin type III domain (Pfam:PF00041) followed by two copies of the Protein-tyrosine phosphatase (Pfam:PF00102) domain. Receptor-type tyrosine-protein phosphatase C (CD45) regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T and B cells. Multiple isoforms of CD45 (180-235 kDa) can be generated asa result of alternative splicing of three variable exons 4(A), 5(B) and 6(C), encoding sequences at the N-terminal extracellular domain of the molecule.	PIRSF:PIRSF002004|IUPHARobj:1852	hp.json	leukocyte common antigen|lymphocyte antigen 5|L-CA|PTPRC|CD45|ly-5|T200	http://purl.obolibrary.org/obo/PR_000001006		
PR:000040662	biolink:Protein	cathepsin-like protease	A protein that is a translation product of some metazoan gene that encodes a signal peptide followed by a single Cathepsin propeptide inhibitor domain (Pfam:PF08246) followed by a single Papain family cysteine protease (Pfam:PF00112) domain at the C terminus.		hp.json	cathepsin|fam:CTS	http://purl.obolibrary.org/obo/PR_000040662		
HP:0011065	biolink:PhenotypicFeature	Conical incisor	An abnormal conical morphology of the incisor tooth.	UMLS:C1856136|UMLS:C4280342|UMLS:C4280341|UMLS:C4020759	hp.json	Cone shaped front tooth|Peg shaped incisors|Pointed incisor|Peg shaped front tooth|Pointed front tooth|Conoid incisor|Shark tooth incisor|Peg-shaped incisors	http://purl.obolibrary.org/obo/HP_0011065		
GO:0051302	biolink:BiologicalProcess	regulation of cell division	Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.		hp.json		http://purl.obolibrary.org/obo/GO_0051302		
GO:0002335	biolink:NamedThing	mature B cell differentiation			hp.json		http://purl.obolibrary.org/obo/GO_0002335		
GO:0051303	biolink:BiologicalProcess	establishment of chromosome localization	The directed movement of a chromosome to a specific location.		hp.json	chromosome positioning|establishment of chromosome localisation	http://purl.obolibrary.org/obo/GO_0051303		
HP:0011067	biolink:PhenotypicFeature	Mesiodens	A supernumerary tooth in the midline between the maxillary central incisors.	MSH:D014096|UMLS:C0266030|UMLS:C0040457|SNOMEDCT_US:17802000|UMLS:C4280340|SNOMEDCT_US:8666004|SNOMEDCT_US:266414008|SNOMEDCT_US:367534004	hp.json	Extra tooth in the midline|Median supernumary tooth|Mesiodentes|Extra tooth|Midline supernumary tooth	http://purl.obolibrary.org/obo/HP_0011067		
GO:0051301	biolink:BiologicalProcess	cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.	Wikipedia:Cell_division	hp.json		http://purl.obolibrary.org/obo/GO_0051301		goslim_pir|goslim_chembl|goslim_drosophila
HP:0011068	biolink:PhenotypicFeature	Odontoma	The presence of an odontoma.	UMLS:C0028882|SNOMEDCT_US:79074005|MSH:D009810	hp.json	Odontomas	http://purl.obolibrary.org/obo/HP_0011068		
GO:0004994	biolink:MolecularActivity	somatostatin receptor activity	Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28).		hp.json	SRIF receptor activity|SST receptor activity|growth hormone-inhibiting hormone receptor activity|GHIH receptor activity|somatotrophin release inhibiting factor receptor activity	http://purl.obolibrary.org/obo/GO_0004994		
HP:0011069	biolink:PhenotypicFeature	Supernumerary tooth	The presence of one or more teeth additional to the normal number.	MSH:D014096|UMLS:C0040457|SNOMEDCT_US:8666004|SNOMEDCT_US:266414008|SNOMEDCT_US:367534004	hp.json	Supernumerary teeth|More teeth than normal|Supernumary teeth|Tooth, supernumerary|Supplemental dentition|Supplemental teeth|Supernumary dentition|Increased tooth count|Extra teeth|Increased number of teeth|Hyperdontia	http://purl.obolibrary.org/obo/HP_0011069		hposlim_core
GO:0004993	biolink:MolecularActivity	G protein-coupled serotonin receptor activity	Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.	Wikipedia:5-HT_receptor	hp.json	G protein coupled serotonin receptor activity|5-HT receptor|5-hydroxytryptamine receptor|G-protein coupled serotonin receptor activity	http://purl.obolibrary.org/obo/GO_0004993		
HP:0011060	biolink:PhenotypicFeature	Dentinogenesis imperfecta limited to primary teeth	Developmental dysplasia of dentin affecting only the primary dentition.	UMLS:C4023558|UMLS:C0011430|SNOMEDCT_US:109492001|MSH:D003805	hp.json	Dentinogenesis imperfecta of baby teeth	http://purl.obolibrary.org/obo/HP_0011060		
HP:0011061	biolink:PhenotypicFeature	Abnormality of dental structure	An abnormality of the structure or composition of the teeth.	UMLS:C4023557	hp.json	Abnormality of tooth structure|Abnormality of tooth part	http://purl.obolibrary.org/obo/HP_0011061		
HP:0011062	biolink:PhenotypicFeature	Misalignment of incisors	Misaligned incisor.	UMLS:C4280343|UMLS:C4023556	hp.json	Abnormality of position of incisors|Crooked incisors|Crooked front teeth|Misalignment of incisors|Malposition of incisors|Abnormality of alignment of incisors	http://purl.obolibrary.org/obo/HP_0011062		
HP:0011063	biolink:PhenotypicFeature	Abnormal incisor morphology	An abnormality of morphology of the incisor tooth.	UMLS:C4023555	hp.json	Abnormality of shape of incisor|Abnormality of incisor morphology	http://purl.obolibrary.org/obo/HP_0011063		
HP:0011064	biolink:PhenotypicFeature	Abnormal number of incisors	The presence of an altered number of the incisor teeth.	UMLS:C4023554	hp.json	Abnormal number of incisors|Abnormal number of front teeth	http://purl.obolibrary.org/obo/HP_0011064		
PR:000001012	biolink:Protein	integrin alpha-M	An integrin alpha with A domain that is a translation product of the human ITGAM gene or a 1:1 ortholog thereof. They constitute subunits of the integrin alpha-M/beta-2 receptor. This receptor is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is also a receptor for fibrinogen, factor X and ICAM1.	IUPHARobj:2452	hp.json	leukocyte adhesion receptor MO1|CD11 antigen-like family member B|ITGAM|cell surface glycoprotein MAC-1 subunit alpha|CD11B|CR3A|CR-3 alpha chain|neutrophil adherence receptor|CD11b	http://purl.obolibrary.org/obo/PR_000001012		
PR:000001014	biolink:Protein	receptor-type tyrosine-protein phosphatase C isoform CD45RABC	A receptor-type tyrosine-protein phosphatase C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-3 or a 1:1 ortholog thereof.		hp.json	CD45R|PTPRC/iso:CD45RABC|B220|CD45RABC	http://purl.obolibrary.org/obo/PR_000001014		
PR:000001013	biolink:Protein	integrin alpha-X	An integrin alpha with A domain that is a translation product of the human ITGAX gene or a 1:1 ortholog thereof. Integrin alpha-X complexed with beta-2 is a receptor for fibrinogen. It recognizes the sequence GPR in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.	IUPHARobj:2454	hp.json	leukocyte adhesion glycoprotein p150,95 alpha chain|CD11 antigen-like family member C|Leu M5|leukocyte adhesion receptor p150,95|CD11C|ITGAX|CD11c	http://purl.obolibrary.org/obo/PR_000001013		
PR:000001015	biolink:Protein	receptor-type tyrosine-protein phosphatase C isoform CD45RA	A receptor-type tyrosine-protein phosphatase C isoform CD45R that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08575-8 or a 1:1 ortholog thereof.		hp.json	CD45RA|PTPRC/iso:CD45RA	http://purl.obolibrary.org/obo/PR_000001015		
PR:000001018	biolink:Protein	CD3 subunit with immunoglobulin domain	A protein with a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response.	PIRSF:PIRSF001993	hp.json	CD3 subunit with Ig-like domain	http://purl.obolibrary.org/obo/PR_000001018		
GO:0004967	biolink:MolecularActivity	glucagon receptor activity	Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.		hp.json		http://purl.obolibrary.org/obo/GO_0004967		
GO:0051319	biolink:BiologicalProcess	G2 phase	The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis).	Wikipedia:G2_phase	hp.json		http://purl.obolibrary.org/obo/GO_0051319		gocheck_do_not_annotate
UBERON:0011823	biolink:AnatomicalEntity	dense connective tissue	Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets.	NCIT:C32450|AAO:0000121|UMLS:C1511770|Wikipedia:Dense_connective_tissue	hp.json		http://purl.obolibrary.org/obo/UBERON_0011823		
UBERON:0011822	biolink:AnatomicalEntity	dense irregular connective tissue	Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium.	FMA:20109|NCIT:C32882|UMLS:C0738366|Wikipedia:Dense_irregular_connective_tissue	hp.json	typus irregularis (textus connectivus collagenosus compactus)|irregular dense connective tissue	http://purl.obolibrary.org/obo/UBERON_0011822		
GO:1905720	biolink:CellularComponent	cytoplasmic microtubule bundle	Any microtubule bundle that is part of a cytoplasm.		hp.json	microtubule fascicle of cytoplasm|microtubule bundle of cytoplasm	http://purl.obolibrary.org/obo/GO_1905720		
UBERON:0011821	biolink:AnatomicalEntity	irregular connective tissue	Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium.	FMA:20107	hp.json		http://purl.obolibrary.org/obo/UBERON_0011821		
UBERON:0011820	biolink:AnatomicalEntity	atrioventricular region	An anatomical junction that divides and overlaps with and atrium and a ventricle in the heart.	EHDAA2:0004149|FMA:85125	hp.json	AV region|AV region|atrioventricular segment|atrial ventricular junction|atrioventricular segment|AV segment|AV segment|atrioventricular junction	http://purl.obolibrary.org/obo/UBERON_0011820		human_reference_atlas
UBERON:0011827	biolink:AnatomicalEntity	areolar gland	A sebaceous glands in the areola surrounding the nipple.	NCIT:C92833|UMLS:C0929386|FMA:58090|MA:0000794|EMAPA:37668	hp.json	gland of Montgomery|accessory gland of Montgomery|accessory gland of breast|mammary gland sebaceous gland|Montgomery's gland	http://purl.obolibrary.org/obo/UBERON_0011827		
UBERON:0011825	biolink:AnatomicalEntity	loose connective tissue	Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue.	UMLS:C1253917|Wikipedia:Loose_connective_tissue|NCIT:C33007|FMA:19783	hp.json	textus connectivus laxus|textus connectivus collagenosus laxus	http://purl.obolibrary.org/obo/UBERON_0011825		
UBERON:0011824	biolink:AnatomicalEntity	fibrous connective tissue		SCTID:363130003|FMA:75634	hp.json		http://purl.obolibrary.org/obo/UBERON_0011824		
CHEBI:16498	biolink:ChemicalSubstance	N-acylneuraminic acid	Any neuraminic acid carrying an N-acyl substituent.	KEGG:C00591	hp.json	N-acylneuraminic acids|5-alkanamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid|N-Acylneuraminate	http://purl.obolibrary.org/obo/CHEBI_16498		3_STAR
GO:0002309	biolink:BiologicalProcess	T cell proliferation involved in immune response	The expansion of a T cell population by cell division as part of an immune response.		hp.json	T cell proliferation during immune response|T lymphocyte proliferation during immune response|T-cell proliferation during immune response|T-lymphocyte proliferation during immune response	http://purl.obolibrary.org/obo/GO_0002309		
GO:0002313	biolink:NamedThing	mature B cell differentiation involved in immune response			hp.json		http://purl.obolibrary.org/obo/GO_0002313		
GO:0051325	biolink:BiologicalProcess	interphase	The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs.	Wikipedia:Interphase	hp.json	karyostasis|resting phase	http://purl.obolibrary.org/obo/GO_0051325		gocheck_do_not_annotate
GO:0002312	biolink:BiologicalProcess	B cell activation involved in immune response	The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.		hp.json	B lymphocyte activation during immune response|B-lymphocyte activation during immune response|B cell activation during immune response|B-cell activation during immune response	http://purl.obolibrary.org/obo/GO_0002312		
PR:000001083	biolink:Protein	CD2 molecule	A protein that is a translation product of the human CD2 gene or a 1:1 ortholog thereof.	IUPHARobj:2600|PIRSF:PIRSF001984	hp.json	CD2|LFA-3 receptor|T-cell surface antigen T11/Leu-5|LFA-2|T-cell surface glycoprotein CD2|lymphocyte antigen 37|erythrocyte receptor|SRBC|T-cell surface antigen CD2|rosette receptor|ly-37	http://purl.obolibrary.org/obo/PR_000001083		
PR:000001084	biolink:Protein	T-cell surface glycoprotein CD8 alpha chain	A protein that is a translation product of the human CD8A gene or a 1:1 ortholog thereof. CD8 is a transmembrane that is a co-receptor for MHC class-I antigen/T-cell receptor interaction. The most common form of CD8 is composed of a CD8 alpha and a CD8 beta chain.	PANTHER:PTHR10441:SF1	hp.json	Lyt-2|Lyt2|MAL|T-lymphocyte differentiation antigen T8/Leu-2|CD8A|CD8a|T-cell surface glycoprotein Lyt-2	http://purl.obolibrary.org/obo/PR_000001084		
GO:2000790	biolink:BiologicalProcess	regulation of mesenchymal cell proliferation involved in lung development	Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.		hp.json		http://purl.obolibrary.org/obo/GO_2000790		
GO:2000791	biolink:BiologicalProcess	negative regulation of mesenchymal cell proliferation involved in lung development	Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.		hp.json		http://purl.obolibrary.org/obo/GO_2000791		
GO:2000792	biolink:BiologicalProcess	positive regulation of mesenchymal cell proliferation involved in lung development	Any process that activates or increases the frequency, rate or extent of mesenchymal cell proliferation involved in lung development.		hp.json		http://purl.obolibrary.org/obo/GO_2000792		
GO:2000794	biolink:BiologicalProcess	regulation of epithelial cell proliferation involved in lung morphogenesis	Any process that modulates the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_2000794		
GO:2000795	biolink:BiologicalProcess	negative regulation of epithelial cell proliferation involved in lung morphogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell proliferation involved in lung morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_2000795		
UBERON:0011814	biolink:AnatomicalEntity	non-neurogenic ectodermal placode	Ectodermal placode that does not develop into a component of the nervous system.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011814		
UBERON:0011819	biolink:AnatomicalEntity	lumen of atrioventricular canal	A tube lumen that is part of a atrioventricular canal.	EHDAA2:0000152	hp.json	AVC lumen|lumen of AVC|cavity of atrioventricular canal	http://purl.obolibrary.org/obo/UBERON_0011819		
UBERON:0011818	biolink:AnatomicalEntity	superficial fascia	Superficial fascia is found in the subcutis in most regions of the body, blending with the reticular layer of the dermis. It is present on the face, over the upper portion of the sternocleidomastoid, at the nape of the neck, and overlying the sternum. It is comprised mainly of loose areolar connective tissue and adipose and is the layer that primarily determines the shape of a body. In addition to its subcutaneous presence, this type of fascia surrounds organs and glands, neurovascular bundles, and is found at many other locations where it fills otherwise unoccupied space. It serves as a storage medium of fat and water; as a passageway for lymph, nerve and blood vessels; and as a protective padding to cushion and insulate. Superficial fascia is present, but does not contain fat, in the eyelids, ear, scrotum, penis and clitoris.	GAID:929|FMA:9630|NCIT:C33660|BTO:0004525|MESH:D040521	hp.json	superficial fascial layer|subcutaneous tissue|tela subcutanea	http://purl.obolibrary.org/obo/UBERON_0011818		pheno_slim
UBERON:0011817	biolink:AnatomicalEntity	skin appendage placode	An ectodermal placode that gives rise to any of the cutaneous appendages that protrude from the skin epidermis (heair, feathers, epidermal scales).		hp.json	cutaneous appendage follicle placode|skin follicle placode	http://purl.obolibrary.org/obo/UBERON_0011817		
GO:0051321	biolink:BiologicalProcess	meiotic cell cycle	Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.	Wikipedia:Meiosis	hp.json	meiosis	http://purl.obolibrary.org/obo/GO_0051321		goslim_drosophila|goslim_yeast
GO:0002318	biolink:BiologicalProcess	myeloid progenitor cell differentiation	The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.		hp.json		http://purl.obolibrary.org/obo/GO_0002318		
GO:0002319	biolink:NamedThing	memory B cell differentiation			hp.json		http://purl.obolibrary.org/obo/GO_0002319		
GO:0051336	biolink:BiologicalProcess	regulation of hydrolase activity	Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.		hp.json	hydrolase regulator	http://purl.obolibrary.org/obo/GO_0051336		
GO:0051339	biolink:BiologicalProcess	regulation of lyase activity	Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.		hp.json	lyase regulator	http://purl.obolibrary.org/obo/GO_0051339		
GO:0051338	biolink:BiologicalProcess	regulation of transferase activity	Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.		hp.json	transferase regulator	http://purl.obolibrary.org/obo/GO_0051338		gocheck_do_not_manually_annotate
GO:1905747	biolink:BiologicalProcess	negative regulation of saliva secretion	Any process that stops, prevents or reduces the frequency, rate or extent of saliva secretion.		hp.json	downregulation of saliva secretion|downregulation of salivation|down regulation of saliva secretion|inhibition of saliva secretion|down-regulation of saliva secretion|down regulation of salivation|inhibition of salivation|negative regulation of salivation|down-regulation of salivation	http://purl.obolibrary.org/obo/GO_1905747		
GO:0051346	biolink:BiologicalProcess	negative regulation of hydrolase activity	Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.		hp.json	down regulation of hydrolase activity|inhibition of hydrolase activity|down-regulation of hydrolase activity|hydrolase inhibitor|downregulation of hydrolase activity	http://purl.obolibrary.org/obo/GO_0051346		
GO:0051347	biolink:BiologicalProcess	positive regulation of transferase activity	Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.		hp.json	up-regulation of transferase activity|activation of transferase activity|upregulation of transferase activity|up regulation of transferase activity|stimulation of transferase activity|transferase activator	http://purl.obolibrary.org/obo/GO_0051347		gocheck_do_not_manually_annotate
GO:0051345	biolink:BiologicalProcess	positive regulation of hydrolase activity	Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.		hp.json	upregulation of hydrolase activity|up regulation of hydrolase activity|stimulation of hydrolase activity|up-regulation of hydrolase activity|activation of hydrolase activity|hydrolase activator	http://purl.obolibrary.org/obo/GO_0051345		
GO:0051348	biolink:BiologicalProcess	negative regulation of transferase activity	Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor.		hp.json	downregulation of transferase activity|down regulation of transferase activity|inhibition of transferase activity|down-regulation of transferase activity|transferase inhibitor	http://purl.obolibrary.org/obo/GO_0051348		gocheck_do_not_manually_annotate
GO:0051349	biolink:BiologicalProcess	positive regulation of lyase activity	Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.		hp.json	lyase activator|upregulation of lyase activity|stimulation of lyase activity|up regulation of lyase activity|activation of lyase activity|up-regulation of lyase activity	http://purl.obolibrary.org/obo/GO_0051349		
GO:1905755	biolink:BiologicalProcess	protein localization to cytoplasmic microtubule	A process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule.		hp.json	protein localisation to cytoplasmic microtubule	http://purl.obolibrary.org/obo/GO_1905755		
GO:0051340	biolink:BiologicalProcess	regulation of ligase activity	Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.		hp.json	ligase regulator	http://purl.obolibrary.org/obo/GO_0051340		
GO:0051341	biolink:BiologicalProcess	regulation of oxidoreductase activity	Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.		hp.json	oxidoreductase regulator	http://purl.obolibrary.org/obo/GO_0051341		
HP:0011010	biolink:PhenotypicFeature	Chronic	Slow, creeping onset, slow progress and long continuance of disease manifestations.	SNOMEDCT_US:90734009|UMLS:C0205191	hp.json	Chronic	http://purl.obolibrary.org/obo/HP_0011010		
HP:0011011	biolink:PhenotypicFeature	Subacute	Somewhat rapid onset and change of disease manifestations.	SNOMEDCT_US:19939008|UMLS:C0205365	hp.json		http://purl.obolibrary.org/obo/HP_0011011		
HP:0011012	biolink:PhenotypicFeature	Abnormal circulating polysaccharide concentration	A deviation from the normal concentration of a polysaccharide in the blood circulation.	UMLS:C4023600	hp.json		http://purl.obolibrary.org/obo/HP_0011012		
HP:0011013	biolink:PhenotypicFeature	Abnormal circulating carbohydrate concentration	A deviation from the normal concentration of a carbohydrate in the blood circulation.	UMLS:C4023599	hp.json		http://purl.obolibrary.org/obo/HP_0011013		
HP:0011014	biolink:PhenotypicFeature	Abnormal glucose homeostasis	Abnormality of glucose homeostasis.	UMLS:C4023598	hp.json		http://purl.obolibrary.org/obo/HP_0011014		
HP:0011015	biolink:PhenotypicFeature	Abnormal blood glucose concentration	An abnormality of the concentration of glucose in the blood.	UMLS:C4023597	hp.json	Abnormality of blood glucose concentration	http://purl.obolibrary.org/obo/HP_0011015		
HP:0011016	biolink:PhenotypicFeature	obsolete Abnormality of urine glucose concentration			hp.json		http://purl.obolibrary.org/obo/HP_0011016		
HP:0011017	biolink:PhenotypicFeature	Abnormal cellular physiology	An abnormality in a cellular process.	UMLS:C4023595	hp.json	Abnormality of cell physiology	http://purl.obolibrary.org/obo/HP_0011017		
HP:0025659	biolink:PhenotypicFeature	Decreased circulating creatine kinase concentration	A reduction in the level of the enzyme creatine kinase (also known as creatine phosphokinase (CK; EC 2.7.3.2) in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0025659		
HP:0001684	biolink:PhenotypicFeature	Secundum atrial septal defect	A kind of atrial septum defect arising from an enlarged foramen ovale, inadequate growth of the septum secundum, or excessive absorption of the septum primum.	UMLS:C0344724|ICD-10:Q21.1|MSH:D006344|SNOMEDCT_US:204315000|Fyler:2000	hp.json	Patent ostium secundum|Ostium secundum atrial septal defect|Atrial septal defect, ostium secundum type	http://purl.obolibrary.org/obo/HP_0001684		
HP:0001685	biolink:PhenotypicFeature	Myocardial fibrosis	Myocardial fibrosis is characterized by dysregulated collagen turnover (increased synthesis predominates over unchanged or decreased degradation) and excessive diffuse collagen accumulation in the interstitial and perivascular spaces as well as by phenotypically transformed fibroblasts, termed myofibroblasts.	UMLS:C0151654	hp.json		http://purl.obolibrary.org/obo/HP_0001685		
HP:0025652	biolink:PhenotypicFeature	Abnormal placental adhesion into the uterine wall	Abnormal placental adhesion is characterized by an anomalous adherence of the placenta to the uterine wall. Based on the degree of adhesion, placental invasion can be classified into accreta, increta, or percreta.		hp.json		http://purl.obolibrary.org/obo/HP_0025652		
HP:0025653	biolink:PhenotypicFeature	Placenta percreta	Placenta percreta is a rare form of morbidly adherent placenta with penetration through the myometrium reaching serosa and even adjacent pelvic organs.		hp.json	Abnormal placental pentration beyond the uterine wall	http://purl.obolibrary.org/obo/HP_0025653		
HP:0001682	biolink:PhenotypicFeature	Subvalvular aortic stenosis	A fixed form of obstruction to blood flow across the left-ventricular outflow tract related to stenosis (narrowing) below the level of the aortic valve.	UMLS:C0340375|MSH:D001020|SNOMEDCT_US:204368006	hp.json	Subaortic stenosis|Narrowing of blood vessel below aortic heart valve	http://purl.obolibrary.org/obo/HP_0001682		
HP:0001683	biolink:PhenotypicFeature	Ectopia cordis	Congenital malformation of the ventral wall with partial or total evisceration of the heart outside the thoracic cavity and through the defect in the ventral wall.	Fyler:0170|MSH:D054083|Fyler:170|UMLS:C0013580|SNOMEDCT_US:78250005	hp.json		http://purl.obolibrary.org/obo/HP_0001683		
HP:0025654	biolink:PhenotypicFeature	Placenta acreta	Abnormally firm adherence of the placenta to the uterine wall.		hp.json		http://purl.obolibrary.org/obo/HP_0025654		
HP:0001688	biolink:PhenotypicFeature	Sinus bradycardia	Bradycardia related to a mean resting sinus rate of less than 50 beats per minute.	UMLS:C0085610|Fyler:7013|SNOMEDCT_US:49710005	hp.json		http://purl.obolibrary.org/obo/HP_0001688		
HP:0025655	biolink:PhenotypicFeature	Placenta increta	Abnormal placental pentration into but not beyond the uterine wall.		hp.json		http://purl.obolibrary.org/obo/HP_0025655		
HP:0025656	biolink:PhenotypicFeature	Prenatal double bubble sign	Sonographic detection of a double bubble sign in the upper abdomen is strongly indicative of duodenal obstruction. One bubble represents fetal stomach, and the other is attributed to a dilated proximal part of the duodenum; continuity between both bubbles is required for the sign.		hp.json		http://purl.obolibrary.org/obo/HP_0025656		
HP:0001686	biolink:PhenotypicFeature	Loss of voice		MSH:D001044|SNOMEDCT_US:44564008|UMLS:C0003564|SNOMEDCT_US:441913003	hp.json	Aphonia	http://purl.obolibrary.org/obo/HP_0001686		
HP:0025657	biolink:PhenotypicFeature	Abnormal umbilical blood flow measurement			hp.json		http://purl.obolibrary.org/obo/HP_0025657		
HP:0025658	biolink:PhenotypicFeature	obsolete Abnormal umbilical artery Doppler pattern in pregnancy			hp.json		http://purl.obolibrary.org/obo/HP_0025658		
HP:0011018	biolink:PhenotypicFeature	Abnormality of the cell cycle	An abnormality of the cell cycle.	UMLS:C4023594	hp.json	Abnormality of the cell cycle	http://purl.obolibrary.org/obo/HP_0011018		
HP:0011019	biolink:PhenotypicFeature	Abnormality of chromosome condensation	An abnormality of chromosome condensation.	UMLS:C4023593	hp.json		http://purl.obolibrary.org/obo/HP_0011019		
HP:0001680	biolink:PhenotypicFeature	Coarctation of aorta	Coarctation of the aorta is a narrowing or constriction of a segment of the aorta.	UMLS:C0003492|MSH:D001017|SNOMEDCT_US:7305005	hp.json	Narrowing of the aorta|Narrowing of aorta|Coarctation of the aorta|Aortic coarctation	http://purl.obolibrary.org/obo/HP_0001680		
HP:0001681	biolink:PhenotypicFeature	Angina pectoris	Paroxysmal chest pain that occurs with exertion or stress and is related to myocardial ischemia.	UMLS:C0002962|SNOMEDCT_US:194828000|MSH:D000787|SNOMEDCT_US:225566008	hp.json		http://purl.obolibrary.org/obo/HP_0001681		
HP:0025650	biolink:PhenotypicFeature	Steroid-dependent nephrotic syndrome	A type of nephrotic syndrome in which two consecutive relapses (albumin urine dipstick at least 3+ or proteinuria greater than 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) occur during corticosteroid therapy, or within 14 days of ceasing therapy.		hp.json	SDNS	http://purl.obolibrary.org/obo/HP_0025650		
HP:0011000	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the optic tract		UMLS:C4023602	hp.json	Absent/small optic tract|Absent/underdeveloped optic tract	http://purl.obolibrary.org/obo/HP_0011000		
HP:0011001	biolink:PhenotypicFeature	Increased bone mineral density	An abnormal increase of bone mineral density, that is, of the amount of matter per cubic centimeter of bones which is often referred to as osteosclerosis. Osteosclerosis can be detected on radiological examination as an increased whiteness (density) of affected bones.	MSH:D010026|SNOMEDCT_US:49347007|UMLS:C0029464	hp.json	Increased bone density|Osteosclerosis|Increased bone mineral density|Osteosclerosis of bones	http://purl.obolibrary.org/obo/HP_0011001		
HP:0011002	biolink:PhenotypicFeature	Osteopetrosis	Abnormally increased formation of dense trabecular bone tissue. Despite the increased density of bone tissue, osteopetrotic bones tend to be more fracture-prone than normal.	MSH:D010022|SNOMEDCT_US:367489004|UMLS:C0029454|SNOMEDCT_US:1926006	hp.json	Albers-Schönberg disease|Marble bone disease|Albers-Schoenberg disease|Albers-Schonberg disease|Harder, denser, fracture-prone bones	http://purl.obolibrary.org/obo/HP_0011002		
HP:0011003	biolink:PhenotypicFeature	High myopia	A severe form of myopia with greater than -6.00 diopters.	SNOMEDCT_US:34187009|UMLS:C0271183	hp.json	Severe near sightedness|Severe myopia|Severely close sighted|Severely near sighted|Severe myopia (> -6.00 diopters)	http://purl.obolibrary.org/obo/HP_0011003		hposlim_core
HP:0011004	biolink:PhenotypicFeature	Abnormal systemic arterial morphology	An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries.	UMLS:C0151489|Fyler:2600|SNOMEDCT_US:234119001|UMLS:C4021205	hp.json	Arterial abnormalities|Abnormal systemic artery morphology|Abnormality of the systemic arterial tree|Systemic artery abnormality	http://purl.obolibrary.org/obo/HP_0011004		
HP:0011005	biolink:PhenotypicFeature	Mixed cirrhosis	A type of cirrhosis characterized by the presence of regenerative nodules of a variety of sizes.	UMLS:C1392669	hp.json		http://purl.obolibrary.org/obo/HP_0011005		
HP:0011006	biolink:PhenotypicFeature	Abnormal morphology of the musculature of the neck	An abnormality of the neck musculature.	UMLS:C4023601	hp.json	Neck muscle issue|Abnormality of cervical musculature|Abnormality of the musculature of the neck	http://purl.obolibrary.org/obo/HP_0011006		
HP:0025648	biolink:PhenotypicFeature	Steroid-sensitive nephrotic syndrome with infrequent relapses	A type of steroid-sensitive nephrotic syndrome in which relapses occur at a frequency of one relapse (albumin urine dipstick at least 3+ or proteinuria over 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) within 6 months of initial response, or one to three relapses in any 12-month period.		hp.json		http://purl.obolibrary.org/obo/HP_0025648		
HP:0025649	biolink:PhenotypicFeature	Steroid-sensitive nephrotic syndrome with frequent relapses	A type of steroid-sensitive nephrotic syndrome in which relapses occur at a frequency of two or more relapses (albumin urine dipstick at least 3+ or proteinuria over 40 mg/m2/d or urinary protein to creatinine ratio at least 2000 mg/g for 3 consecutive days) within 6 months of initial response or four or more relapses in any 12-month period.		hp.json		http://purl.obolibrary.org/obo/HP_0025649		
HP:0025640	biolink:PhenotypicFeature	Abnormal urinary mineral level	An abnormal concentration or amount of a mineral in the urine. Medically relevant minerals include calcium, phosphorus, potassium, sodium, chloride, magnesium, iron, zinc, iodine, chromium, copper, fluoride, molybdenum, manganese, and selenium.		hp.json		http://purl.obolibrary.org/obo/HP_0025640		
HP:0001695	biolink:PhenotypicFeature	Cardiac arrest	An abrupt loss of heart function.	SNOMEDCT_US:397829000|MSH:D006323|SNOMEDCT_US:410429000|UMLS:C0018790	hp.json	Heart stops beating	http://purl.obolibrary.org/obo/HP_0001695		
HP:0001696	biolink:PhenotypicFeature	Situs inversus totalis	A left-right reversal (or "mirror reflection") of the anatomical location of the major thoracic and abdominal organs.	MSH:D059446|Fyler:100|SNOMEDCT_US:27317008|UMLS:C0266642|SNOMEDCT_US:43876007|UMLS:C0037221|MSH:D012857|Fyler:0100|SNOMEDCT_US:14821001|SNOMEDCT_US:24614000	hp.json	situs oppositus|situs transversus|Situs inversus|All organs on wrong side of body	http://purl.obolibrary.org/obo/HP_0001696		
HP:0025641	biolink:PhenotypicFeature	Elevated circulating glycolate concentration	An abnormally increased concentration of glycolate in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025641		
HP:0001693	biolink:PhenotypicFeature	Cardiac shunt	Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system.	SNOMEDCT_US:442119001|UMLS:C0232180	hp.json		http://purl.obolibrary.org/obo/HP_0001693		
HP:0025643	biolink:PhenotypicFeature	Tarlov cyst	A cerebrospinal fluid-filled nerve root cyst most often localized in the sacral spine.		hp.json	Perineural cyst	http://purl.obolibrary.org/obo/HP_0025643		
HP:0001694	biolink:PhenotypicFeature	Right-to-left shunt	Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the right side of the heart to the left.	SNOMEDCT_US:79692001|UMLS:C0428871	hp.json		http://purl.obolibrary.org/obo/HP_0001694		
HP:0001699	biolink:PhenotypicFeature	Sudden death	Rapid and unexpected death.	UMLS:C0011071|SNOMEDCT_US:26636000|MSH:D003645	hp.json		http://purl.obolibrary.org/obo/HP_0001699		
HP:0025644	biolink:PhenotypicFeature	Fixation-off epileptiform discharges	Fixation off sensitivity (FOS) is characterized by posterior or generalized epileptiform discharges that consistently occur with conditions that eliminate central vision, such as closed eyes, complete darkness, modified Ganzfeld stimulation (using a large white surface without visual cues), and Frenzel lenses. The FOS electroencephalogram (EEG) pattern usually consists of spikes/polyspikes and waves localized in occipital regions (bilateral or unilateral) or generalized discharges. It is usually inhibited by fixation of gaze, observing patterns, or intermittent photic stimulation (e.g., flashing light or patterns used as stimuli during the recording of the EEG).		hp.json	Fixation-off sensitivity	http://purl.obolibrary.org/obo/HP_0025644		
HP:0001697	biolink:PhenotypicFeature	Abnormal pericardium morphology	An abnormality of the pericardium, i.e., of the fluid filled sac that surrounds the heart and the proximal ends of the aorta, vena cava, and the pulmonary artery.	Fyler:1900|UMLS:C4025754	hp.json	Abnormality of the pericardium	http://purl.obolibrary.org/obo/HP_0001697		
HP:0025646	biolink:PhenotypicFeature	Bilateral polymicrogyria	Polymicrogyria that affects all or some of both cerebral hemispheres.		hp.json		http://purl.obolibrary.org/obo/HP_0025646		
HP:0001698	biolink:PhenotypicFeature	Pericardial effusion	Accumulation of fluid within the pericardium.	MSH:D010490|Fyler:1940|SNOMEDCT_US:373945007|UMLS:C0031039	hp.json	Pericardial effusions|Fluid around heart	http://purl.obolibrary.org/obo/HP_0001698		
HP:0025647	biolink:PhenotypicFeature	Steroid-sensitive nephrotic syndrome	A type of nephrotic syndrome in which complete remission (albumin urine dipstick negative/trace or proteinuria <4mg/m2/d or urinary protein to creatinine ratio <200mg/g (<20 mg/mmol) for 3 consecutive days) is achieved within initial 4 weeks of corticosteroid therapy.		hp.json	SSNS	http://purl.obolibrary.org/obo/HP_0025647		
HP:0011008	biolink:PhenotypicFeature	Temporal pattern	The speed at which disease manifestations appear and develop.	UMLS:C4021204	hp.json	Speed of onset	http://purl.obolibrary.org/obo/HP_0011008		
HP:0011009	biolink:PhenotypicFeature	Acute	Sudden appearance of disease manifestations over a short period of time.	UMLS:C0205178|SNOMEDCT_US:272118002	hp.json	Acute onset	http://purl.obolibrary.org/obo/HP_0011009		
HP:0001691	biolink:PhenotypicFeature	Muscular subvalvular aortic stenosis	A type of subvalvular aortic stenosis resulting from thickening of the musculature of the interventricular septum, which results in obstruction to blood flow through the left-ventricular outflow tract.	UMLS:C3887554	hp.json	Muscular subaortic stenosis	http://purl.obolibrary.org/obo/HP_0001691		
HP:0001692	biolink:PhenotypicFeature	Atrial arrhythmia	A type of supraventricular tachycardia in which the atria are the principal site of electrophysiologic disturbance.	SNOMEDCT_US:17366009|UMLS:C0085611|UMLS:C4025755	hp.json	Primary atrial arrhythmia	http://purl.obolibrary.org/obo/HP_0001692		
HP:0025637	biolink:PhenotypicFeature	Vasospasm	Narrowing of an artery due to constriction of the blood vessels.		hp.json	Vascular spasm|Angiospasm|Blood vessel spasm	http://purl.obolibrary.org/obo/HP_0025637		
HP:0025638	biolink:PhenotypicFeature	Elevated urinary N-butyrylglycine	An increased level of N-butyrylglycine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0025638		
HP:0025639	biolink:PhenotypicFeature	Increased urinary zinc level	An abnormally elevated amount of zinc in the urine, typically as assessed by a 24 hour urine collection.		hp.json		http://purl.obolibrary.org/obo/HP_0025639		
HP:0001669	biolink:PhenotypicFeature	Transposition of the great arteries	A complex congenital heart defect in which the aorta arises from the morphologic right ventricle and the pulmonary artery arises from the morphologic left ventricle.	SNOMEDCT_US:204296002|SNOMEDCT_US:26146002|UMLS:C3536741	hp.json	Transposition of great vessels	http://purl.obolibrary.org/obo/HP_0001669		
HP:0001662	biolink:PhenotypicFeature	Bradycardia	A slower than normal heart rate (in adults, slower than 60 beats per minute).	MSH:D001919|UMLS:C0428977|SNOMEDCT_US:48867003	hp.json	Slow heartbeats|Brachycardia	http://purl.obolibrary.org/obo/HP_0001662		
HP:0001663	biolink:PhenotypicFeature	Ventricular fibrillation	Uncontrolled contractions of muscles fibers in the left ventricle not producing contraction of the left ventricle. Ventricular fibrillation usually begins with a ventricular premature contraction and a short run of rapid ventricular tachycardia degenerating into uncoordinating ventricular fibrillations.	UMLS:C0042510|MSH:D014693|SNOMEDCT_US:71908006	hp.json		http://purl.obolibrary.org/obo/HP_0001663		
HP:0025630	biolink:PhenotypicFeature	Argininosuccinic aciduria	Increased amount of argininosuccinate in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0025630		
HP:0001660	biolink:PhenotypicFeature	Truncus arteriosus	A single arterial trunk arises from the cardiac mass. The pulmonary arteries, aorta and coronary arteries arise from this single trunk with no evidence of another outflow tract.	MSH:D014338|Fyler:500|SNOMEDCT_US:58140002|ICD-10:Q20.0|Fyler:0500|UMLS:C4020867|UMLS:C0041206	hp.json	Common arterial trunk|Persistant truncus arteriosus	http://purl.obolibrary.org/obo/HP_0001660		
HP:0025631	biolink:PhenotypicFeature	Alpha-aminobutyric aciduria	Increased amount of alpha-aminobutyric acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0025631		
HP:0025632	biolink:PhenotypicFeature	Reduced reactive oxygen species production in neutrophils			hp.json		http://purl.obolibrary.org/obo/HP_0025632		
HP:0025633	biolink:PhenotypicFeature	Abnormal ureter morphology	A structural abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder.		hp.json		http://purl.obolibrary.org/obo/HP_0025633		
HP:0001667	biolink:PhenotypicFeature	Right ventricular hypertrophy	In this case the right ventricle is more muscular than normal, causing a characteristic boot-shaped (coeur-en-sabot) appearance as seen on anterior- posterior chest x-rays. Right ventricular hypertrophy is commonly associated with any form of right ventricular outflow obstruction or pulmonary hypertension, which may in turn owe its origin to left-sided disease. The echocardiographic signs are thickening of the anterior right ventricular wall and the septum. Cavity size is usually normal, or slightly enlarged. In many cases there is associated volume overload present due to tricuspid regurgitation, in the absence of this, septal motion is normal.	MSH:D017380|Fyler:3609|UMLS:C0162770|SNOMEDCT_US:89792004	hp.json	Heart right ventricle hypertrophy	http://purl.obolibrary.org/obo/HP_0001667		
HP:0025634	biolink:PhenotypicFeature	Abnormal ureter physiology	A functional abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder.		hp.json		http://purl.obolibrary.org/obo/HP_0025634		
HP:0025635	biolink:PhenotypicFeature	Ureteral polyp	A growth protruding from the mucous membrane of the ureter. Ureteral polyps can be attached to the ureter by a broad base or a thin stalk.	NCIT:C4530	hp.json	Polyp of the ureter|Ureter polyp	http://purl.obolibrary.org/obo/HP_0025635		
HP:0001664	biolink:PhenotypicFeature	Torsade de pointes	A type of ventricular tachycardia characterized by polymorphioc QRS complexes that change in amplitue and cycle length, and thus have the appearance of oscillating around the baseline in the EKG.	UMLS:C0040479|MSH:D016171|SNOMEDCT_US:31722008	hp.json	Torsades de pointes	http://purl.obolibrary.org/obo/HP_0001664		
HP:0025636	biolink:PhenotypicFeature	Endometritis	Inflammation of the inner lining of the uterus (endometrium).		hp.json	Endometrial inflammation|Inflammation of the inner lining of the uterus	http://purl.obolibrary.org/obo/HP_0025636		
HP:0025626	biolink:PhenotypicFeature	Increased circulating oleate level	An abnormally high concentration of oleic acid (oleate) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025626		
HP:0025627	biolink:PhenotypicFeature	Increased circulating octadecanoate level	An abnormally high concentration of octadecanoate in the blood circulation. Octadecanoate is a fatty acid anion 18:0 that is the conjugate base of octadecanoic acid (stearic acid).		hp.json		http://purl.obolibrary.org/obo/HP_0025627		
HP:0001679	biolink:PhenotypicFeature	Abnormal aortic morphology	An abnormality of the aorta.	UMLS:C4025756|Fyler:1453	hp.json	Abnormality of the aorta|Abnormal aorta morphology	http://purl.obolibrary.org/obo/HP_0001679		
HP:0025628	biolink:PhenotypicFeature	Increased circulating myristoleate level	An abnormally high concentration of myristoleate in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025628		
HP:0025629	biolink:PhenotypicFeature	Anti-myelin-associated glycoprotein antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against myelin-associated glycoprotein (MAG).		hp.json		http://purl.obolibrary.org/obo/HP_0025629		
HP:0001673	biolink:PhenotypicFeature	obsolete Tachycardia (with pheochromocytoma)			hp.json		http://purl.obolibrary.org/obo/HP_0001673		
HP:0001674	biolink:PhenotypicFeature	Complete atrioventricular canal defect	A congenital heart defect characterized by a specific combination of heart defects with a common atrioventricular valve, primum atrial septal defect and inlet ventricular septal defect.	Fyler:1120	hp.json	Complete atrioventricular septal defect|Complete common AV canal|Common atrioventricular canal|Atrioventricular canal	http://purl.obolibrary.org/obo/HP_0001674		
HP:0001671	biolink:PhenotypicFeature	Abnormal cardiac septum morphology	An anomaly of the intra-atrial or intraventricular septum.	UMLS:C0018816|MSH:D006343|SNOMEDCT_US:396351009|SNOMEDCT_US:59494005|SNOMEDCT_US:253273004	hp.json	Abnormality of the cardiac septa|Septal defects|Heart septal defect	http://purl.obolibrary.org/obo/HP_0001671		
HP:0025620	biolink:PhenotypicFeature	Abnormal proportion of CD4+ central memory cells	An abnormal proportion of central memory CD4+ T cells. These are memory cells that are located in the secondary lymphoid organs. These cells may have a CD3/CD4/CD62L+/CD45RA- phenotype.		hp.json	Abnormal proportion of central memory CD4+, alpha-beta T cells	http://purl.obolibrary.org/obo/HP_0025620		
HP:0025621	biolink:PhenotypicFeature	obsolete Increased proportion of CD4+ central memory cells			hp.json		http://purl.obolibrary.org/obo/HP_0025621		
HP:0001677	biolink:PhenotypicFeature	Coronary artery atherosclerosis	Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries, which increases the risk of myocardial ischemia.	MSH:D003324|SNOMEDCT_US:53741008|SNOMEDCT_US:414024009|UMLS:C1956346	hp.json	Coronary disease|Plaque build-up in arteries supplying blood to heart|Coronary atherosclerosis	http://purl.obolibrary.org/obo/HP_0001677		
HP:0025622	biolink:PhenotypicFeature	obsolete Decreased proportion of CD4+ central memory cells			hp.json		http://purl.obolibrary.org/obo/HP_0025622		
HP:0025623	biolink:PhenotypicFeature	Abnormal proportion of CD4+ effector memory cells	An abnormal proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells have the phenotype CD3-positive, CD4-positive, CD62L-negative, CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json	Abnormal proportion of CD4-positive effector memory cells|Abnormal proportion of effector memory CD4-positive, alpha-beta T cells	http://purl.obolibrary.org/obo/HP_0025623		
HP:0001678	biolink:PhenotypicFeature	Atrioventricular block	Delayed or lack of conduction of atrial depolarizations through the atrioventricular node to the ventricles.	UMLS:C1841659|UMLS:C0004245|MSH:D054537|SNOMEDCT_US:233917008	hp.json	Interruption of electrical communication between upper and lower chambers of heart|Atrioventricular nodal disease	http://purl.obolibrary.org/obo/HP_0001678		
HP:0025624	biolink:PhenotypicFeature	Reduced proportion of CD4+ effector memory T cells	An abnormally decreased proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells have the phenotype CD3-positive, CD4-positive, CD62L-ngative, CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json	Decreased proportion of CD4+ effector memory T cells|Decreased proportion of CD4-positive effector memory T cells|Decreased proportion of effector memory CD4-positive, alpha-beta T cells	http://purl.obolibrary.org/obo/HP_0025624		
HP:0001675	biolink:PhenotypicFeature	obsolete Rhythm disturbances associated with pheochromocytoma			hp.json		http://purl.obolibrary.org/obo/HP_0001675		
HP:0025625	biolink:PhenotypicFeature	Elevated proportion of CD4+ effector memory T cells	An abnormally increased proportion of effector memory CD4+ T cells. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells may have a CD3/CD4/CD62L-/CD45RA phenotype.		hp.json	Increased proportion of effector CD4-positive, alpha-beta T cells|Increased proportion of CD4-positive effector memory T cells|Increased proportion of CD4+ effector memory T cells	http://purl.obolibrary.org/obo/HP_0025625		
HP:0001676	biolink:PhenotypicFeature	obsolete Palpitations (with pheochromocytoma)			hp.json		http://purl.obolibrary.org/obo/HP_0001676		
HP:0001670	biolink:PhenotypicFeature	Asymmetric septal hypertrophy	Hypertrophic cardiomyopathy with an asymmetrical pattern of hypertrophy, with a predilection for the interventricular septum and myocyte disarray.	UMLS:C0205700	hp.json		http://purl.obolibrary.org/obo/HP_0001670		
HP:0011054	biolink:PhenotypicFeature	Agenesis of molar	Agenesis of molar tooth.	UMLS:C4280348|UMLS:C4021203	hp.json	Absence of molar|Absent molars|Missing molar|Failure of development of molar	http://purl.obolibrary.org/obo/HP_0011054		
HP:0011055	biolink:PhenotypicFeature	Agenesis of permanent molar	Agenesis of secondary molar tooth.	UMLS:C4280347|UMLS:C4023563	hp.json	Agenesis of secondary molar|Failure of development of secondary molar|Absence of permanent molar|Absence of adult molar|Missing permanent molar|Failure of development of permanent molar|Missing adult molar	http://purl.obolibrary.org/obo/HP_0011055		
HP:0011056	biolink:PhenotypicFeature	Agenesis of first permanent molar tooth	Agenesis of either maxillary first permanent molar or mandibular first permanent molar or both.	UMLS:C4280346|UMLS:C4023562	hp.json	Absence of first permanent molar|Missing six year molar|Failure of development of first permanent molar|Missing first permanent molar|Failure of development of six year molar|Agenesis of six year molar|Absence of six year molar	http://purl.obolibrary.org/obo/HP_0011056		
HP:0011057	biolink:PhenotypicFeature	Agenesis of second permanent molar	Agenesis of either mandibular second permanent molar or maxillary second permanent molar.	UMLS:C4280257|UMLS:C4023561	hp.json	Absence of twelve year molar|Agenesis of twelve year molar|Absence of second permanent molar|Missing twelve year molar|Failure of development of second permanent molar|Failure of development of twelve year molar|Missing second permanent molar	http://purl.obolibrary.org/obo/HP_0011057		
HP:0011058	biolink:PhenotypicFeature	Generalized periodontitis	A generalized form of periodontitis.	UMLS:C4023560|UMLS:C4280345	hp.json	Generalised periodontitis|Generalised gum disease|Generalized gum disease|Widespread gum disease|Generalized periodontal disease|Generalised periodontal disease	http://purl.obolibrary.org/obo/HP_0011058		
HP:0011059	biolink:PhenotypicFeature	Localized periodontitis	A localized form of periodontitis.	UMLS:C4280344|UMLS:C4023559	hp.json	Limited area of gum disease|Localised gum disease|Localized gum disease|Localized periodontal disease|Localised periodontal disease|Localised periodontitis	http://purl.obolibrary.org/obo/HP_0011059		
HP:0410309	biolink:PhenotypicFeature	Alpha-aminoadipic aciduria	A increased concentration of alpha-aminoadipic acid in the urine.		hp.json	2-aminoadipic aciduria	http://purl.obolibrary.org/obo/HP_0410309		
HP:0410308	biolink:PhenotypicFeature	Decreased specific antibody response to infection	A reduced ability to synthesize antibodies against antigens from an infectious agent or pathogen (such as bacteria, viruses, parasites, etc.), as measured by antibody titer determination following infection.		hp.json		http://purl.obolibrary.org/obo/HP_0410308		
GO:0002384	biolink:NamedThing	hepatic immune response			hp.json		http://purl.obolibrary.org/obo/GO_0002384		
HP:0410307	biolink:PhenotypicFeature	Positive stool methadone test	Detection of methadone and its metabolites in the stool.		hp.json		http://purl.obolibrary.org/obo/HP_0410307		
HP:0011050	biolink:PhenotypicFeature	Agenesis of permanent maxillary lateral incisor	Agenesis of one or more upper lateral secondary incisor.	UMLS:C4280352|UMLS:C4023567	hp.json	Absence of permanent maxillary lateral incisor|Missing permanent maxillary lateral incisor|Missing permanent upper lateral incisor|Failure of development of permanent maxillary lateral incisor|Agenesis of permanent upper lateral incisor|Failure of development of permanent upper lateral incisor	http://purl.obolibrary.org/obo/HP_0011050		
HP:0011051	biolink:PhenotypicFeature	Agenesis of premolar	Agenesis of premolar tooth.	UMLS:C4280351|UMLS:C4023566	hp.json	Missing premolar|Failure of development of premolar|Absence of premolar|Missing bicuspid|Absence of bicuspid|Failure of development of bicuspid|Agenesis of bicuspid	http://purl.obolibrary.org/obo/HP_0011051		
HP:0011052	biolink:PhenotypicFeature	Agenesis of maxillary premolar	Agenesis of maxillary premolar.	UMLS:C4280350|UMLS:C4023565	hp.json	Failure of development of maxillary bicuspid|Absence of maxillary bicuspid|Agenesis of maxillary bicuspid|Missing maxillary premolar|Missing upper premolar|Absence of maxillary premolar|Failure of development of maxillary premolar|Absence of upper premolar|Missing upper bicuspid	http://purl.obolibrary.org/obo/HP_0011052		
HP:0011053	biolink:PhenotypicFeature	Agenesis of mandibular premolar	Agenesis of mandibular premolar.	UMLS:C4023564|UMLS:C4280349	hp.json	Missing mandibular premolar|Failure of development of mandibular premolar|Missing lower premolar|Absence of lower premolar|Absence of mandibular premolar	http://purl.obolibrary.org/obo/HP_0011053		
HP:0410302	biolink:PhenotypicFeature	Decreased specific antibody response to protein-conjugated polysaccharide vaccine	A reduced ability to synthesize postvaccination antibodies against protein-conjugated polysaccharides in vaccines, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410302		
HP:0025695	biolink:PhenotypicFeature	Mucus plug	Mucus that is abnormally thick in consistency (ie, inspissated) and plugs the airway is known as a mucus plug. Mucus plugs consist of mucins and cells and can partially or completely obstruct one or more airways and cause serious consequences, including atelectasis and recurrent infection.		hp.json		http://purl.obolibrary.org/obo/HP_0025695		
HP:0410301	biolink:PhenotypicFeature	Partial absence of specific antibody response to unconjugated pneumococcus vaccine	A reduced ability to synthesize postvaccination antibodies against a pneumococcus antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410301		
HP:0025696	biolink:PhenotypicFeature	Airway casts	A replicate of airways from accumulated and condensed mucous and cellular material. These semisolid occlusions take the shape of the airway within they are formed, leading to obstruction of the tracheobronchial tree with consecutive respiratory insufficiency. Based on their principal composition, one can differentiate fibrin casts and mucin casts. Plastic bronchitis is the name of the condition characterized by the formation of airway casts.		hp.json		http://purl.obolibrary.org/obo/HP_0025696		
HP:0410300	biolink:PhenotypicFeature	Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vaccine	The inability to synthesize postvaccination antibodies against a pneumococcus antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410300		
HP:0025697	biolink:PhenotypicFeature	Fibrin casts	A type of airway casts that consist of plasma components and inflammatory cells.		hp.json	Type I airway casts|Pseudomembranes|Cellular airway casts|Diphtheroid membranes	http://purl.obolibrary.org/obo/HP_0025697		
HP:0025698	biolink:PhenotypicFeature	Mucin casts	A type of airway casts that consist of impacted mucus.		hp.json	Type II airway casts|Acellular airway casts	http://purl.obolibrary.org/obo/HP_0025698		
HP:0410306	biolink:PhenotypicFeature	Partial absence of specific antibody response to meningococcus vaccine	A reduced ability to synthesize postvaccination antibodies against a meningococcus antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410306		
HP:0025699	biolink:PhenotypicFeature	Perisylvian FDG hypermetabolism	18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (FDG-PET/CT) evaluates the glucose metabolism of the brain. FDG uptake is interpreted to represent glycolysis. This term therefore represents an abnormally increased FDG uptake (increased glucose metabolism) in the region of the brain that surrounds the Sylvian fissure.		hp.json	Perisylvian hypermetabolism in FDG PET	http://purl.obolibrary.org/obo/HP_0025699		
HP:0410305	biolink:PhenotypicFeature	Partial absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine	A reduced ability to synthesize postvaccination antibodies against a Haemophilus influenzae type b (Hib) antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410305		
HP:0410304	biolink:PhenotypicFeature	Complete or near-complete absence of specific antibody response to meningococcus vaccine	The inability to synthesize postvaccination antibodies against a meningococcus antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410304		
HP:0410303	biolink:PhenotypicFeature	Complete or near-complete absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine	The inability to synthesize postvaccination antibodies against a Haemophilus influenzae type b (Hib) antigen, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0410303		
HP:0025690	biolink:PhenotypicFeature	Fetal intra-abdominal umbilical vein varix	Fetal intra-abdominal umbilical vein varix (FIUVV) is defined by the focal dilatation of the fetal umbilical vein between its entry in the abdomen and its ending in the portal system. The dilatation can be defined using one of the following criteria: a portion of intra-abdominal umbilical vein that is at least 50% wider than the non-dilated portion; a dilatation of 9 mm or more, or a dilatation greater than 2 SD above the mean value for gestational age.		hp.json	FIUVV|Fetal umbilical vein dilatation	http://purl.obolibrary.org/obo/HP_0025690		
HP:0025691	biolink:PhenotypicFeature	Impaired fasting glucose	Impaired fasting glucose (IFG) is indicated by a fasting plasma glucose above normal but below the diabetic range. Levels between 110 mg/dl (6.1 mmol/l) to 125 mg/dl (6.9 mmol/l) are diagnostic of IFG.		hp.json		http://purl.obolibrary.org/obo/HP_0025691		
HP:0025692	biolink:PhenotypicFeature	Atelencephaly	A defect of development of the brain characterized by absence of the telencephalon (embryonic structure from which the mature cerebrum develops).		hp.json		http://purl.obolibrary.org/obo/HP_0025692		
HP:0025693	biolink:PhenotypicFeature	Pituitary macroadenoma	A pituitary gland adenoma that is larger than 10mm.		hp.json	Pituitary gland macroadenoma	http://purl.obolibrary.org/obo/HP_0025693		
HP:0025694	biolink:PhenotypicFeature	Pituitary microadenoma	A pituitary adenoma that is less than 10 mm in diameter.		hp.json		http://purl.obolibrary.org/obo/HP_0025694		
HP:0011043	biolink:PhenotypicFeature	Abnormal circulating adrenocorticotropin concentration	An abnormal concentration of corticotropin in the blood.	UMLS:C4023574	hp.json	Abnormality of circulating adrenocorticotropin level|Abnormality of circulating corticotropin level|Abnormality of circulating adrenocorticotropic hormone level|Abnormality of circulating ACTH level	http://purl.obolibrary.org/obo/HP_0011043		
HP:0011044	biolink:PhenotypicFeature	Abnormal number of permanent teeth	The presence of an altered number of of permanent teeth.	UMLS:C4023573	hp.json	Abnormal complement of permanent teeth|Abnormal permanent tooth count|Abnormal number of permanent teeth|Abnormal number of secondary dentition|Abnormal number of adult teeth	http://purl.obolibrary.org/obo/HP_0011044		
HP:0011045	biolink:PhenotypicFeature	Agenesis of permanent maxillary central incisor	Agenesis of upper secondary incisor.	UMLS:C4023572|UMLS:C4280359|UMLS:C4280358	hp.json	Missing permanent maxillary central incisor|Missing permanent upper central incisor|Failure of development of permanent maxillary central incisor|Missing permanent upper front tooth|Agenesis of adult maxillary central incisor|Missing adult upper central incisor|Absence of permanent maxillary central incisor|Absence of permanent upper central incisor|Absence of permanent upper front tooth	http://purl.obolibrary.org/obo/HP_0011045		
HP:0011046	biolink:PhenotypicFeature	Agenesis of primary maxillary central incisor	Agenesis of upper central primary incisor.	UMLS:C4023571|UMLS:C4280357	hp.json	Absence of upper front baby tooth|Absence of deciduous maxillary central incisor|Missing upper front milk tooth|Absence of primary maxillary central incisor|Missing deciduous maxillary central incisor|Agenesis of deciduous maxillary central incisor|Failure of development of deciduous maxillary central incisor|Missing primary maxillary central incisor|Missing upper front baby tooth|Failure of development of primary maxillary central incisor	http://purl.obolibrary.org/obo/HP_0011046		
HP:0011047	biolink:PhenotypicFeature	Agenesis of primary mandibular central incisor	Agenesis of lower primary incisor.	UMLS:C4023570|UMLS:C4280356|UMLS:C4280355	hp.json	Agenesis of primary lower central incisor|Missing primary mandibular central incisor|Missing lower front milk tooth|Missing deciduous mandibular central incisor|Absence of primary mandibular central incisor|Failure of development of primary mandibular central incisor|Absence of deciduous mandibular central incisor|Missing lower central incisor milk tooth|Failure of development of deciduous mandibular central incisor|Missing lower front baby tooth|Agenesis of deciduous lower central incisor|Missing lower front primary tooth	http://purl.obolibrary.org/obo/HP_0011047		
HP:0011048	biolink:PhenotypicFeature	Agenesis of permanent mandibular central incisor	Agenesis of lower secondary incisor.	UMLS:C4280354|UMLS:C4023569	hp.json	Absence of permanent lower central incisor|Absence of permanent lower front tooth|Missing permanent mandibular central incisor|Agenesis of adult mandibular central incisor|Missing permanent lower central incisor|Missing permanent lower front tooth|Failure of development of permanent mandibular central incisor|Absence of permanent mandibular central incisor|Missing adult lower central incisor	http://purl.obolibrary.org/obo/HP_0011048		
HP:0011049	biolink:PhenotypicFeature	Agenesis of primary maxillary lateral incisor	Agenesis of one or more maxillary lateral incisor, comprising the maxillary lateral primary incisor.	UMLS:C4280353|UMLS:C4023568	hp.json	Absence of deciduous maxillary lateral incisor|Absence of primary maxillary lateral incisor|Missing deciduous maxillary lateral incisor|Agenesis of deciduous maxillary lateral incisor|Failure of development of deciduous maxillary lateral incisor|Missing primary maxillary lateral incisor|Failure of development of primary maxillary lateral incisor	http://purl.obolibrary.org/obo/HP_0011049		
GO:0002399	biolink:BiologicalProcess	MHC class II protein complex assembly	The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.		hp.json		http://purl.obolibrary.org/obo/GO_0002399		
GO:0002396	biolink:BiologicalProcess	MHC protein complex assembly	The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.		hp.json		http://purl.obolibrary.org/obo/GO_0002396		
HP:0011040	biolink:PhenotypicFeature	Abnormal intrahepatic bile duct morphology	An abnormality of the intrahepatic bile duct.	UMLS:C4023577	hp.json	Abnormality of the intrahepatic bile duct	http://purl.obolibrary.org/obo/HP_0011040		
HP:0011041	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the cervical spine	Aplasia or developmental hypoplasia of the cervical vertebral column.	UMLS:C4023576	hp.json	Absent/small cervical spine|Absent/underdeveloped cervical spine	http://purl.obolibrary.org/obo/HP_0011041		
HP:0011042	biolink:PhenotypicFeature	Abnormal blood potassium concentration	An abnormal concentration of potassium.	UMLS:C4023575	hp.json	Abnormal blood K concentration|Abnormality of potassium homeostasis	http://purl.obolibrary.org/obo/HP_0011042		
HP:0025684	biolink:PhenotypicFeature	Decreased amyloid beta 42 peptide CSF concentration	A reduction from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF).		hp.json		http://purl.obolibrary.org/obo/HP_0025684		
HP:0025685	biolink:PhenotypicFeature	Increased amyloid beta 42 peptide CSF concentration	An elevation above the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF).		hp.json		http://purl.obolibrary.org/obo/HP_0025685		
HP:0025686	biolink:PhenotypicFeature	Abnormal amyloid beta 40 peptide CSF concentration	Any deviation from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF). Amyloid beta is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. ABeta40, which is 40 amino acids in length, is the shorter form.		hp.json	Abnormal Abeta 40 level|Abnormal beta amyloid 40 level	http://purl.obolibrary.org/obo/HP_0025686		
HP:0025687	biolink:PhenotypicFeature	Increased amyloid beta 40 peptide CSF concentration	An elevation above the normal concentration of amyloid beta 40 peptide in the cerebrospinal fluid (CSF).		hp.json		http://purl.obolibrary.org/obo/HP_0025687		
HP:0025688	biolink:PhenotypicFeature	Abnormal amyloid beta peptide CSF concentration	Any anomaly in the concentration of a cleaved APP amyloid beta protein fragment in the cerebrospinal fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0025688		
HP:0025689	biolink:PhenotypicFeature	Extra-abdominal umbilical vein varix	Focal dilatation of the extra-abdominal portion of the umbilical vein. An extra-abdominal umbilical varix is difficult to diagnose prenatally as it can appear like a cyst on ultrasound prior to birth.		hp.json		http://purl.obolibrary.org/obo/HP_0025689		
HP:0025680	biolink:PhenotypicFeature	Compound muscle action potential amplitude facilitation	Compound muscle action potential amplitude (CMAP) facilitation denotes an increase in tendon reflexes, strength, or CMAP amplitude after 10 seconds of maximal voluntary contraction.		hp.json	CMAP facilitation	http://purl.obolibrary.org/obo/HP_0025680		
HP:0025681	biolink:PhenotypicFeature	Distal clavicular thinning	Abnormally reduced diameter (cross section) of the clavicles that is limited to the distal region.		hp.json		http://purl.obolibrary.org/obo/HP_0025681		
HP:0025682	biolink:PhenotypicFeature	Crouch gait	A gait disturbance that is characterized by excessive ankle dorsiflexion, knee and hip flexion during the stance phase.		hp.json		http://purl.obolibrary.org/obo/HP_0025682		
HP:0025683	biolink:PhenotypicFeature	Abnormal amyloid beta 42 peptide CSF concentration	Any deviation from the normal concentration of amyloid beta 42 peptide in the cerebrospinal fluid (CSF). Amyloid beta is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. ABeta42, which is 42 amino acids in length, is the longer form.		hp.json		http://purl.obolibrary.org/obo/HP_0025683		
HP:0011032	biolink:PhenotypicFeature	Abnormality of fluid regulation	An abnormality of the regulation of body fluids.	SNOMEDCT_US:1860003|UMLS:C2364164|SNOMEDCT_US:190902006	hp.json	Fluid imbalance|Abnormality of fluid regulation	http://purl.obolibrary.org/obo/HP_0011032		
HP:0011033	biolink:PhenotypicFeature	Impairment of fructose metabolism	An impairment of a fructose metabolic process.	UMLS:C4023581	hp.json		http://purl.obolibrary.org/obo/HP_0011033		
GO:0002369	biolink:BiologicalProcess	T cell cytokine production	Any process that contributes to cytokine production by a T cell.		hp.json	T-cell cytokine production|T lymphocyte cytokine production|T-lymphocyte cytokine production	http://purl.obolibrary.org/obo/GO_0002369		gocheck_do_not_annotate
HP:0011034	biolink:PhenotypicFeature	Amyloidosis	The presence of amyloid deposition in one or more tissues. Amyloidosis may be defined as the extracellular deposition of amyloid in one or more sites of the body.	SNOMEDCT_US:17602002|UMLS:C0002726|MSH:D000686	hp.json	Amyloid disease	http://purl.obolibrary.org/obo/HP_0011034		
HP:0011035	biolink:PhenotypicFeature	Abnormal renal cortex morphology	An abnormality of the cortex of the kidney.	UMLS:C4023580	hp.json	Abnormality of renal cortex morphology	http://purl.obolibrary.org/obo/HP_0011035		
HP:0011036	biolink:PhenotypicFeature	Abnormality of renal excretion	An altered ability of the kidneys to void urine and/or specific substances.	MP:0005555|UMLS:C4023579	hp.json		http://purl.obolibrary.org/obo/HP_0011036		
HP:0011037	biolink:PhenotypicFeature	Decreased urine output	A decreased rate of urine production.	UMLS:C3887784	hp.json		http://purl.obolibrary.org/obo/HP_0011037		
HP:0011038	biolink:PhenotypicFeature	Abnormal renal tubular resorption	An abnormality of renal absorption.	UMLS:C4023578	hp.json	Abnormality of renal resorption|Abnormal renal resorption	http://purl.obolibrary.org/obo/HP_0011038		
GO:0002366	biolink:BiologicalProcess	leukocyte activation involved in immune response	A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.		hp.json	immune cell activation during immune response|leucocyte activation during immune response|leukocyte activation during immune response	http://purl.obolibrary.org/obo/GO_0002366		
GO:0002367	biolink:BiologicalProcess	cytokine production involved in immune response	The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.		hp.json	cytokine biosynthetic process involved in immune response|cytokine secretion involved in immune response|cytokine secretion during immune response|cytokine production during immune response	http://purl.obolibrary.org/obo/GO_0002367		gocheck_do_not_annotate
HP:0011039	biolink:PhenotypicFeature	Abnormal helix morphology	An abnormality of the helix. The helix is the outer rim of the ear that extends from the insertion of the ear on the scalp (root) to the termination of the cartilage at the earlobe.	UMLS:C1856660	hp.json	Abnormality of the helix|Abnormal helices|Helix abnormal	http://purl.obolibrary.org/obo/HP_0011039		hposlim_core
HP:0410329	biolink:PhenotypicFeature	Gluten allergy	Hypersensitivity in form of an adverse immune reaction against gluten.		hp.json	IgE-mediated gluten allergy|Immunoglobulin E-mediated gluten allergy|Gluten allergy|Allergy to gluten	http://purl.obolibrary.org/obo/HP_0410329		
HP:0011030	biolink:PhenotypicFeature	Abnormal blood transition element cation concentration	An abnormality of the homeostasis (concentration) of transition element cation.	UMLS:C4023584	hp.json	Abnormality of transition element cation homeostasis	http://purl.obolibrary.org/obo/HP_0011030		
HP:0011031	biolink:PhenotypicFeature	Abnormality of iron homeostasis	An abnormality of the homeostasis (concentration) of iron cation.	UMLS:C4023583	hp.json		http://purl.obolibrary.org/obo/HP_0011031		
HP:0410324	biolink:PhenotypicFeature	Dust mite allergy	Hypersensitivity in form of an adverse immune reaction against dust mites.		hp.json	Dust mite allergy|Immunoglobulin E-mediated dust mite allergy|IgE-mediated dust mite allergy|Allergy to dust mites	http://purl.obolibrary.org/obo/HP_0410324		
HP:0025673	biolink:PhenotypicFeature	Loculated ascites	A type of ascites (peritoneal fluid collection) that is divided into loculi (compartments) by septa (fibrous walls). Ascites fluid can become loculated when confined by adhesions, malignancy or infection.		hp.json	Septated ascites	http://purl.obolibrary.org/obo/HP_0025673		
HP:0025674	biolink:PhenotypicFeature	Meconium pseudocyst	A meconium-containing cyst in the peritoneal space . Meconium pseudocysts form in the presence of meconium peritonitis, which is defined as a sterile peritonitis caused by escape of meconium from the intestinal tract into the general peritoneal cavity during the fetal or perinatal period. When the extruded meconium becomes walled off, it can form a rim-calcified mass representing the meconium pseudocyst.		hp.json		http://purl.obolibrary.org/obo/HP_0025674		
HP:0410323	biolink:PhenotypicFeature	Drug allergy	Hypersensitivity in form of an adverse immune reaction against drugs.		hp.json	Drug allergy|Allergy to drugs|IgE-mediated drug allergy|Immunoglobulin E-mediated drug allergy	http://purl.obolibrary.org/obo/HP_0410323		
HP:0025675	biolink:PhenotypicFeature	Premature closure of the ductus arteriosus	A prenatal partial or complete closure of the ductus arteriosus (i.e., prior to delivery).		hp.json	PCDA|Fetal PAD narrowing-closure|Idiopathic constriction of the fetal ductus arteriosus|Fetal arterial duct narrowing-closure|Fetal PDA narrowing-closure|Fetal ductus arteriosus narrowing-closure	http://purl.obolibrary.org/obo/HP_0025675		
HP:0410322	biolink:PhenotypicFeature	Bacteria allergy	Hypersensitivity in form of an adverse immune reaction against bacteria.		hp.json	IgE-mediated bacteria allergy|Immunoglobulin E-mediated bacteria allergy|Bacteria allergy|Allergy to bacteria	http://purl.obolibrary.org/obo/HP_0410322		
HP:0025676	biolink:PhenotypicFeature	Fetal pleural effusion	Fetal pleural effusion is the accumulation of excess fluid in the layers of tissue (pleura) lining the lungs and wall of the chest. It may be primary, also termed hydrothorax, occurring as an isolated finding or it may be secondary, most commonly resulting from non-immune hydrops.		hp.json		http://purl.obolibrary.org/obo/HP_0025676		
HP:0410321	biolink:PhenotypicFeature	Animal dander allergy	Hypersensitivity in form of an adverse immune reaction against animal dander.		hp.json	Allergy to animal dander|Immunoglobulin E-mediated animal dander allergy|Animal dander allergy|IgE-mediated animal dander allergy	http://purl.obolibrary.org/obo/HP_0410321		
HP:0025677	biolink:PhenotypicFeature	Fetal chylothorax	The presence of chyle (a type of lipid-rich lymph) in the pleural space (the space surrounding the lung) as observed in a fetus.		hp.json		http://purl.obolibrary.org/obo/HP_0025677		
HP:0410328	biolink:PhenotypicFeature	Egg allergy	Hypersensitivity in form of an adverse immune reaction against eggs.		hp.json	Egg allergy|Immunoglobulin E-mediated egg allergy|IgE-mediated egg allergy|Allergy to eggs	http://purl.obolibrary.org/obo/HP_0410328		
HP:0410327	biolink:PhenotypicFeature	Dairy allergy	Hypersensitivity in form of an adverse immune reaction against dairy.		hp.json	Dairy allergy|Immunoglobulin E-mediated dairy allergy|IgE-mediated dairy allergy|Allergy to dairy	http://purl.obolibrary.org/obo/HP_0410327		
HP:0025678	biolink:PhenotypicFeature	Fetal hydrothorax	Accumulation of lymphatic fluid in the pleural space. This finding is usually observed by prenatal sonography. Once neonatal feeding is established and the lymphatic fluid contains chyle, transformation to chylothorax may be observed.		hp.json		http://purl.obolibrary.org/obo/HP_0025678		
HP:0025679	biolink:PhenotypicFeature	Diskitis	Inflammation of an intervertebral disc or disk space.		hp.json	Discitis	http://purl.obolibrary.org/obo/HP_0025679		
HP:0410326	biolink:PhenotypicFeature	Feather allergy	Hypersensitivity in form of an adverse immune reaction against feathers.		hp.json	Feather allergy|Immunoglobulin E-mediated feather allergy|IgE-mediated feather allergy|Allergy to feathers	http://purl.obolibrary.org/obo/HP_0410326		
HP:0410325	biolink:PhenotypicFeature	House dust mite allergy	Hypersensitivity in form of an adverse immune reaction against house dust mites.		hp.json	House dust mite allergy|Immunoglobulin E-mediated house dust mite allergy|IgE-mediated house dust mite allergy|Allergy to house dust mites	http://purl.obolibrary.org/obo/HP_0410325		
HP:0410320	biolink:PhenotypicFeature	Animal protein allergy	Hypersensitivity in form of an adverse immune reaction against animal proteins.		hp.json	Animal protein allergy|Allergy to animal proteins|IgE-mediated animal protein allergy|Immunoglobulin E-mediated animal protein allergy	http://purl.obolibrary.org/obo/HP_0410320		
HP:0025670	biolink:PhenotypicFeature	Syntelencephaly	Syntelencephaly is a rare malformation that consists of an abnormal midline connection of the cerebral hemispheres in the posterior frontal and parietal regions, with interhemispheric separation of the basal forebrain, anterior frontal lobes, and occipital regions.		hp.json		http://purl.obolibrary.org/obo/HP_0025670		
HP:0025671	biolink:PhenotypicFeature	Fetal pericardial effusion	An abnormal accumulation of fluid in which the heart is partially or completely surrounded by fluid that is seen in all views and the thickness of the fluid as observed by prenatal ultrasound is above age-dependent norms.		hp.json		http://purl.obolibrary.org/obo/HP_0025671		
HP:0025672	biolink:PhenotypicFeature	Fetal skin edema	A separation of skin in one or more regions of the body or even along the entire length of body wall (to a degree greater than gestational-age related norms) related to pathologically increased fluid accumulation in the subcutaneous tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0025672		
HP:0011021	biolink:PhenotypicFeature	Abnormality of circulating enzyme level		UMLS:C4023591	hp.json		http://purl.obolibrary.org/obo/HP_0011021		
HP:0011022	biolink:PhenotypicFeature	Abnormal circulating unsaturated fatty acid concentration	A deviation from the normal concentration of an unsaturated fatty acid in the blood circulation.	UMLS:C4023590	hp.json		http://purl.obolibrary.org/obo/HP_0011022		
HP:0011023	biolink:PhenotypicFeature	Abnormal circulating prostaglandin circulation	Any deviation from the normal concentration of a prostaglandin in the blood circulation.	UMLS:C4023589	hp.json		http://purl.obolibrary.org/obo/HP_0011023		
HP:0011024	biolink:PhenotypicFeature	Abnormality of the gastrointestinal tract	An abnormality of the gastrointestinal tract.	SNOMEDCT_US:25374005|SNOMEDCT_US:119292006|MSH:D004066|UMLS:C0012242|SNOMEDCT_US:53619000|UMLS:C0017178|UMLS:C4023588|MSH:D005767	hp.json	Abnormality of the GI tract|Gastrointestinal disease|Digestive system disease|Abnormality of the gastrointestinal tract	http://purl.obolibrary.org/obo/HP_0011024		
HP:0011025	biolink:PhenotypicFeature	Abnormal cardiovascular system physiology	Abnormal functionality of the cardiovascular system.	UMLS:C4023587	hp.json	Abnormality of cardiovascular system physiology	http://purl.obolibrary.org/obo/HP_0011025		
GO:0002376	biolink:BiologicalProcess	immune system process	Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.	Wikipedia:Immune_system	hp.json		http://purl.obolibrary.org/obo/GO_0002376		goslim_flybase_ribbon|goslim_chembl|goslim_mouse|goslim_agr|goslim_generic|goslim_pir
HP:0011026	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the vagina	Aplasia or developmental hypoplasia of the vagina.	UMLS:C4023586	hp.json	Absent/underdeveloped vagina|Absent/small vagina	http://purl.obolibrary.org/obo/HP_0011026		
HP:0011027	biolink:PhenotypicFeature	Abnormal fallopian tube morphology	An abnormality of the fallopian tube.	UMLS:C0281842	hp.json	Abnormality of the fallopian tube	http://purl.obolibrary.org/obo/HP_0011027		
HP:0011028	biolink:PhenotypicFeature	Abnormality of blood circulation	An abnormality of blood circulation.	UMLS:C4020760|UMLS:C4023585	hp.json	Blood circulation disorder	http://purl.obolibrary.org/obo/HP_0011028		
GO:0002371	biolink:BiologicalProcess	dendritic cell cytokine production	Any process that contributes to cytokine production by a dendritic cell.		hp.json		http://purl.obolibrary.org/obo/GO_0002371		gocheck_do_not_annotate
GO:0002372	biolink:BiologicalProcess	myeloid dendritic cell cytokine production	Any process that contributes to cytokine production by a myeloid dendritic cell.		hp.json		http://purl.obolibrary.org/obo/GO_0002372		gocheck_do_not_annotate
HP:0410319	biolink:PhenotypicFeature	Alpha-gal allergy	Hypersensitivity in form of an adverse immune reaction against alpha-gal.		hp.json	Allergy to alpha-gal|Immunoglobulin E-mediated alpha-gal allergy|Alpha-gal allergy|IgE-mediated alpha-gal allergy	http://purl.obolibrary.org/obo/HP_0410319		
HP:0410318	biolink:PhenotypicFeature	Decreased urinary 3-methylhistidine	Decreased concentration of 3-methylhistidine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410318		
HP:0011020	biolink:PhenotypicFeature	Abnormality of mucopolysaccharide metabolism	An abnormality of the metabolism of mucopolysaccharide.	UMLS:C4023592	hp.json		http://purl.obolibrary.org/obo/HP_0011020		
HP:0025662	biolink:PhenotypicFeature	Abnormal fetal skeletal morphology	An anomlous structural finding of the fetal skeleton. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other terms from the skeletal hierarchy can also be used to describe fetal phenotypes.		hp.json		http://purl.obolibrary.org/obo/HP_0025662		
HP:0410313	biolink:PhenotypicFeature	Abnormal urinary 1-methylhistidine concentration	Abnormal concentration of 1-methylhistidine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410313		
HP:0410312	biolink:PhenotypicFeature	Hypersegmentation of neutrophil nuclei in CSF	An excessive division of the lobes of the nucleus of a neutrophil in the cerebrospinal fluid.		hp.json	Hypersegmentation of neutrophil nuclei in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0410312		
HP:0025663	biolink:PhenotypicFeature	Reduced fetal femur/foot length ratio	This ratio relates the length of the fetal femur to that of the fetal foot. The ratio is approximately 1 throughout the age range of 14 to 40 weeks of gestation. A substantial reduction in the raio can help differentiate fetuses that have dysplastic limb reduction from those whose limbs are short because of constitutional factors or IUGR. It can reduce the problem of an unknown gestational age and help to distinguish between fetal skeletal dysplasia and intrauterine growth retardation caused by other factors.		hp.json		http://purl.obolibrary.org/obo/HP_0025663		
HP:0410311	biolink:PhenotypicFeature	Hyposegmentation of neutrophil nuclei in CSF	Hyposegmented (hypolobulated) or bilobed neutrophil nuclei in the cerebrospinal fluid.		hp.json	Hyposegmentation of neutrophil nuclei in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0410311		
HP:0025664	biolink:PhenotypicFeature	Moderate to late preterm birth	Birth at 32 to 36 completed weeks of gestation.		hp.json		http://purl.obolibrary.org/obo/HP_0025664		
HP:0410310	biolink:PhenotypicFeature	Abnormality of neutrophil morphology in CSF	An abnormal form or size of neutrophils in the cerebrospinal fluid.		hp.json	Abnormality of neutrophil morphology in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0410310		
HP:0025665	biolink:PhenotypicFeature	Extremely preterm birth	Birth before 28 completed weeks of gestation (up to and including 27 weeks and 6 days of gestation).		hp.json		http://purl.obolibrary.org/obo/HP_0025665		
HP:0025666	biolink:PhenotypicFeature	Very preterm birth	Birth before 32 completed weeks of gestation (28 up to but not including 32 weeks).		hp.json		http://purl.obolibrary.org/obo/HP_0025666		
HP:0410317	biolink:PhenotypicFeature	Increased urinary 3-methylhistidine	Increased concentration of 3-methylhistidine in the urine.		hp.json	3-Methylhistidinuria	http://purl.obolibrary.org/obo/HP_0410317		
HP:0025667	biolink:PhenotypicFeature	Fetal neck anomaly	A structural anomaly in the fetal neck region. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.		hp.json		http://purl.obolibrary.org/obo/HP_0025667		
HP:0410316	biolink:PhenotypicFeature	Abnormal urinary 3-methylhistidine level	Abnormal amount of 3-methylhistidine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410316		
HP:0025668	biolink:PhenotypicFeature	Abnormal neck morphology	Any structural anomaly of the neck region.		hp.json		http://purl.obolibrary.org/obo/HP_0025668		
HP:0410315	biolink:PhenotypicFeature	Increased urinary 1-methylhistidine	Increased concentration of 1-methylhistidine in the urine.		hp.json	1-Methylhistidinuria	http://purl.obolibrary.org/obo/HP_0410315		
HP:0410314	biolink:PhenotypicFeature	Decreased urinary 1-methylhistidine	Decreased concentration of 1-methylhistidine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410314		
HP:0025669	biolink:PhenotypicFeature	Abnormal neck physiology	Any functional anomaly of the neck region.		hp.json		http://purl.obolibrary.org/obo/HP_0025669		
HP:0011029	biolink:PhenotypicFeature	Internal hemorrhage	The presence of hemorrhage within the body.	UMLS:C1390214	hp.json	Internal haemorrhage|Internal bleeding	http://purl.obolibrary.org/obo/HP_0011029		
HP:0025660	biolink:PhenotypicFeature	Chiari type II malformation	A type of Chiari malformation that consists of brainstem herniation and a towering cerebellum in addition to the herniated cerebellar tonsils and vermis due to an open distal spinal dysraphism/myelomeningocele.		hp.json	Arnold-Chiari type II malformation	http://purl.obolibrary.org/obo/HP_0025660		
HP:0025661	biolink:PhenotypicFeature	Chiari type III malformation	A type of Chiari malformation that involves herniation of the hindbrain (cerebellum with or without the brainstem) into a low occipital or high cervical meningoencephalocele.		hp.json	Arnold-Chiari type III malformation	http://purl.obolibrary.org/obo/HP_0025661		
HP:0001847	biolink:PhenotypicFeature	Long hallux	Increased length of the big toe.	UMLS:C1864375	hp.json	Long big toe|Large halluces|Long halluces|Increased length of the hallux	http://purl.obolibrary.org/obo/HP_0001847		hposlim_core
HP:0001844	biolink:PhenotypicFeature	Abnormality of the hallux	This term applies for all abnormalities of the big toe, also called hallux.	UMLS:C4021773	hp.json	Abnormalities of the hallux|Abnormality of the big toe	http://purl.obolibrary.org/obo/HP_0001844		hposlim_core
HP:0001845	biolink:PhenotypicFeature	Overlapping toe	Describes a foot digit resting on the dorsal surface of an adjacent digit when the foot is at rest.	SNOMEDCT_US:203541003|UMLS:C0920299	hp.json	Overlapping toes|Crossover toe|Overlapping toe|Overriding toes	http://purl.obolibrary.org/obo/HP_0001845		hposlim_core
HP:0001848	biolink:PhenotypicFeature	Calcaneovalgus deformity	This is a postural deformity in which the foot is positioned up against the tibia. The heel (calcaneus) is positioned downward (that is, the ankle is flexed upward), and the heel is turned outward (valgus).	UMLS:C1860450	hp.json	Calcaneovalgus|Calcaneovalgus Foot|Foot and ankle bend up toward shin of leg|Valgus position of the calcaneus	http://purl.obolibrary.org/obo/HP_0001848		
HP:0001849	biolink:PhenotypicFeature	Foot oligodactyly	A developmental defect resulting in the presence of fewer than the normal number of toes.	SNOMEDCT_US:249820005|UMLS:C0426934	hp.json	Oligodactyly of feet|Missing toes	http://purl.obolibrary.org/obo/HP_0001849		hposlim_core
GO:1903078	biolink:BiologicalProcess	positive regulation of protein localization to plasma membrane	Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.		hp.json	positive regulation of protein localisation in plasma membrane|activation of protein localisation in plasma membrane|activation of protein-plasma membrane targeting|up regulation of protein localization to plasma membrane|up-regulation of protein-plasma membrane targeting|activation of protein targeting to plasma membrane|positive regulation of protein targeting to plasma membrane|activation of protein localization to plasma membrane|up-regulation of protein localization in plasma membrane|up regulation of protein-plasma membrane targeting|up regulation of protein targeting to plasma membrane|upregulation of protein localisation in plasma membrane|positive regulation of establishment of protein localization to plasma membrane|positive regulation of establishment of protein localisation in plasma membrane|positive regulation of protein-plasma membrane targeting|up-regulation of protein targeting to plasma membrane|upregulation of protein localization to plasma membrane|up regulation of protein localization in plasma membrane|activation of protein localization in plasma membrane|positive regulation of protein localization in plasma membrane|upregulation of protein-plasma membrane targeting|up-regulation of protein localisation in plasma membrane|upregulation of protein localization in plasma membrane|upregulation of protein targeting to plasma membrane|up-regulation of protein localization to plasma membrane|up regulation of protein localisation in plasma membrane	http://purl.obolibrary.org/obo/GO_1903078		
GO:1903077	biolink:BiologicalProcess	negative regulation of protein localization to plasma membrane	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to plasma membrane.		hp.json	negative regulation of establishment of protein localization to plasma membrane|down regulation of protein localization in plasma membrane|downregulation of protein-plasma membrane targeting|negative regulation of establishment of protein localisation in plasma membrane|inhibition of protein localization in plasma membrane|downregulation of protein localization in plasma membrane|down-regulation of protein localisation in plasma membrane|negative regulation of establishment of protein localization in plasma membrane|down-regulation of protein localization to plasma membrane|inhibition of protein targeting to plasma membrane|down regulation of protein localisation in plasma membrane|downregulation of protein targeting to plasma membrane|negative regulation of protein localisation in plasma membrane|negative regulation of protein-plasma membrane targeting|down-regulation of protein-plasma membrane targeting|inhibition of protein localisation in plasma membrane|down regulation of protein localization to plasma membrane|downregulation of protein localisation in plasma membrane|inhibition of protein-plasma membrane targeting|down regulation of protein targeting to plasma membrane|down-regulation of protein localization in plasma membrane|inhibition of protein localization to plasma membrane|negative regulation of protein localization in plasma membrane|down regulation of protein-plasma membrane targeting|negative regulation of protein targeting to plasma membrane|down-regulation of protein targeting to plasma membrane|downregulation of protein localization to plasma membrane	http://purl.obolibrary.org/obo/GO_1903077		
GO:1903076	biolink:BiologicalProcess	regulation of protein localization to plasma membrane	Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.		hp.json	regulation of establishment of protein localization in plasma membrane|regulation of protein localization in plasma membrane|regulation of protein targeting to plasma membrane|regulation of establishment of protein localization to plasma membrane|regulation of establishment of protein localisation in plasma membrane|regulation of protein localisation in plasma membrane|regulation of protein-plasma membrane targeting	http://purl.obolibrary.org/obo/GO_1903076		
HP:0001842	biolink:PhenotypicFeature	Foot acroosteolysis		UMLS:C4025744	hp.json	Acroosteolysis of feet	http://purl.obolibrary.org/obo/HP_0001842		
HP:0001840	biolink:PhenotypicFeature	Metatarsus adductus	The metatarsals are deviated medially (tibially), that is, the bones in the front half of the foot bend or turn in toward the body.	MSH:D000070592|UMLS:C0231791|SNOMEDCT_US:77599005|UMLS:C4082169	hp.json	Intoe|Forefoot varus|Front half of foot turns inward|Metatarsus varus|Metatarsus adductovarsus	http://purl.obolibrary.org/obo/HP_0001840		hposlim_core
HP:0001841	biolink:PhenotypicFeature	Preaxial foot polydactyly	Duplication of all or part of the first ray.	UMLS:C2112942|MSH:C566632|UMLS:C1866339	hp.json	Preaxial polydactyly of the feet|Preaxial polydactyly of foot|Preaxial polydactyly of feet|Partial/complete duplication of the phalanges of the big toe|Preaxial polydactyly, feet|Preaxial hallucal polydactyly|Polydactyly affecting the hallux	http://purl.obolibrary.org/obo/HP_0001841		
GO:0110148	biolink:BiologicalProcess	biomineralization	The process where mineral crystals are formed and deposited in an organized fashion in a matrix (either cellular or extracellular) by living organisms. This gives rise to inorganic compound-based structures such as skeleton, teeth, ivory, shells, cuticle, and corals as well as bacterial biomineralization products.	Wikipedia:Biomineralization	hp.json	mineralization|biomineralisation|biomineral formation|mineralisation	http://purl.obolibrary.org/obo/GO_0110148		
GO:0110149	biolink:BiologicalProcess	regulation of biomineralization	Any process that modulates the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms.		hp.json	regulation of mineralization|regulation of biomineral formation|regulation of biomineralisation|regulation of mineralisation	http://purl.obolibrary.org/obo/GO_0110149		
HP:0001857	biolink:PhenotypicFeature	Short distal phalanx of toe	Short distance from the end of the toe to the most distal interphalangeal crease or distal interphalangeal joint flexion point, i.e., abnormally short distal phalanx of toe.	UMLS:C4021771	hp.json	Short outermost bone of toe|Hypoplastic distal phalanges of feet	http://purl.obolibrary.org/obo/HP_0001857		
HP:0001859	biolink:PhenotypicFeature	Distal foot symphalangism		UMLS:C4025743	hp.json		http://purl.obolibrary.org/obo/HP_0001859		
HP:0001850	biolink:PhenotypicFeature	Abnormality of the tarsal bones	An abnormality of the tarsus are the cluster of seven bones in the foot between the tibia and fibula and the metatarsus, including the calcaneus (heel) bone and the talus (ankle) bone.	UMLS:C1862136	hp.json	Abnormal ankle bones|Abnormal tarsals	http://purl.obolibrary.org/obo/HP_0001850		
HP:0001853	biolink:PhenotypicFeature	Bifid distal phalanx of toe		UMLS:C4021772	hp.json	Bifid distal phalanges of toes|Notched outermost bones of toes|Bifid terminal phalanx of toe	http://purl.obolibrary.org/obo/HP_0001853		
HP:0001854	biolink:PhenotypicFeature	Podagra	Gout affecting the Metatarsophalangeal joint of big toe.	SNOMEDCT_US:67148009|UMLS:C0221168	hp.json	Gout of big toe	http://purl.obolibrary.org/obo/HP_0001854		
HP:0001852	biolink:PhenotypicFeature	Sandal gap	A widely spaced gap between the first toe (the great toe) and the second toe.	UMLS:C1840069	hp.json	Wide space between 1st, 2nd toes|Wide-spaced big toe|Widened gap first and second toe|Widely spaced 1st-2nd toes|Wide space between first and second toes|Increased space between first and second toes|Widened gap 1st-2nd toes|Space between great toe and second toe|Gap between 1st and 2nd toes|Widely spaced first and second toes|Gap between first and second toe|Sandal gap between first and second toes	http://purl.obolibrary.org/obo/HP_0001852		hposlim_core
UBERON:0008281	biolink:AnatomicalEntity	tooth bud	A knoblike tooth primordium that develops into the mature tooth and consists of enamel organ, dental papilla, and dental sac enclosing them.	MESH:D014083|BTO:0001838|FMA:306006|NCIT:C34313|UMLS:C0040442	hp.json	tooth germ|dental bud|dental germ	http://purl.obolibrary.org/obo/UBERON_0008281		
HP:0001824	biolink:PhenotypicFeature	Weight loss	Reduction of total body weight.	SNOMEDCT_US:161832001|UMLS:C1262477|SNOMEDCT_US:89362005|SNOMEDCT_US:262285001|MSH:D015431	hp.json	Loss of weight	http://purl.obolibrary.org/obo/HP_0001824		
GO:0110151	biolink:BiologicalProcess	positive regulation of biomineralization	Any process that activates or increases the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms.		hp.json	positive regulation of mineralization|positive regulation of biomineral formation|positive regulation of biomineralisation|positive regulation of mineralisation	http://purl.obolibrary.org/obo/GO_0110151		
HP:0001822	biolink:PhenotypicFeature	Hallux valgus	Lateral deviation of the great toe (i.e., in the direction of the little toe).	UMLS:C0006386|MSH:D000071378|MSH:D006215|SNOMEDCT_US:415692008|UMLS:C0018536|SNOMEDCT_US:122480009	hp.json	Lateral deviation of halluces|Lateral deviation of great toe|Bunion	http://purl.obolibrary.org/obo/HP_0001822		
GO:0110150	biolink:BiologicalProcess	negative regulation of biomineralization	Any process that stops, prevents, or reduces the frequency, rate or extent of biomineralization, the formation and deposition of mineral crystals by living organisms.		hp.json	negative regulation of biomineral formation|negative regulation of mineralisation|negative regulation of biomineralisation|negative regulation of mineralization	http://purl.obolibrary.org/obo/GO_0110150		
HP:0001829	biolink:PhenotypicFeature	Foot polydactyly	A kind of polydactyly characterized by the presence of a supernumerary toe or toes.	SNOMEDCT_US:62218008|UMLS:C0158734	hp.json	Polydactyly of feet|Polydactyly of the foot|Duplication of bones of the toes	http://purl.obolibrary.org/obo/HP_0001829		hposlim_core
HP:0001827	biolink:PhenotypicFeature	Genital tract atresia	Congenital occlusion of a tube in the genital tract.	UMLS:C4025746	hp.json		http://purl.obolibrary.org/obo/HP_0001827		
HP:0001820	biolink:PhenotypicFeature	Leukonychia	White discoloration of the nails.	SNOMEDCT_US:111202002|UMLS:C0240182|MEDDRA:10050658	hp.json	White discoloration of nails	http://purl.obolibrary.org/obo/HP_0001820		
HP:0001821	biolink:PhenotypicFeature	Broad nail	Increased width of nail.	UMLS:C1843112	hp.json	Wide fingernails|Broad fingernails|Broad nail	http://purl.obolibrary.org/obo/HP_0001821		
GO:0110165	biolink:CellularComponent	cellular anatomical entity	A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex.		hp.json		http://purl.obolibrary.org/obo/GO_0110165		
HP:0001836	biolink:PhenotypicFeature	Camptodactyly of toe	Camptodactyly is a painless flexion contracture of the proximal interphalangeal (PIP) joint that is usually gradually progressive. This term refers to camptodactyly of one or more toes.	UMLS:C4021774	hp.json	Camptodactyly of feet	http://purl.obolibrary.org/obo/HP_0001836		
HP:0001833	biolink:PhenotypicFeature	Long foot	Increased back to front length of the foot.	SNOMEDCT_US:299462005|UMLS:C0576225	hp.json	Disproportionately large feet|large feet|Long foot|long feet	http://purl.obolibrary.org/obo/HP_0001833		hposlim_core
HP:0001839	biolink:PhenotypicFeature	Split foot	A condition in which middle parts of the foot (toes and metatarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe over absent 2nd or 3rd toes as far as oligo- or monodactyl feet.	SNOMEDCT_US:205358006|UMLS:C0432028	hp.json	Lobster-claw foot deformity|Split foot|Split-foot|Foot ectrodactyly	http://purl.obolibrary.org/obo/HP_0001839		hposlim_core
HP:0001837	biolink:PhenotypicFeature	Broad toe	Visible increase in width of the non-hallux digit without an increase in the dorso-ventral dimension.	UMLS:C1865038	hp.json	Broad toe|Wide toe	http://purl.obolibrary.org/obo/HP_0001837		hposlim_core
HP:0001838	biolink:PhenotypicFeature	Rocker bottom foot	The presence of both a prominent heel and a convex contour of the sole.	UMLS:C0240912|SNOMEDCT_US:205082007|MSH:D005413|SNOMEDCT_US:205359003|MEDDRA:10066242|MSH:C536345	hp.json	Congenital vertical talus|Rocker-bottom feet|Rocker bottom feet|Rocker bottom foot|Rockerbottom feet	http://purl.obolibrary.org/obo/HP_0001838		hposlim_core
HP:0001831	biolink:PhenotypicFeature	Short toe	A toe that appears disproportionately short compared to the foot.	UMLS:C1836195	hp.json	Stubby toes|Short toe|Hypoplasia of the toe|Brachydactyly of the foot|Hypoplastic toes|Short foot phalanges|Short toes	http://purl.obolibrary.org/obo/HP_0001831		hposlim_core
HP:0001832	biolink:PhenotypicFeature	Abnormal metatarsal morphology	Abnormalities of the metatarsal bones (i.e. of five tubular bones located between the tarsal bones of the hind- and mid-foot and the phalanges of the toes).	UMLS:C4025745	hp.json	Abnormality of the long bone of foot	http://purl.obolibrary.org/obo/HP_0001832		
HP:0001830	biolink:PhenotypicFeature	Postaxial foot polydactyly	Polydactyly of the foot most commonly refers to the presence of six toes on one foot. Postaxial polydactyly affects the lateral ray and the duplication may range from a well-formed articulated digit to a rudimentary digit.	UMLS:C2112129|UMLS:C4020865	hp.json	Posterior polydactyly of foot|Postaxial polydactyly of foot|Postaxial polydactyly of feet|Fibular polydactyly|Polydactyly affecting the 5th toe|Extra toe attached near the little toe	http://purl.obolibrary.org/obo/HP_0001830		
HP:0011210	biolink:PhenotypicFeature	EEG with occipital slowing	Slowing in occipital areas of the scalp EEG.	UMLS:C4023465	hp.json		http://purl.obolibrary.org/obo/HP_0011210		
HP:0011211	biolink:PhenotypicFeature	EEG with photoparoxysmal response grade I	Occurrence of epileptiform discharges in occipital regions during photic stimulation.	UMLS:C4023464	hp.json		http://purl.obolibrary.org/obo/HP_0011211		
PR:000003809	biolink:Protein	alpha-fetoprotein	A protein that is a translation product of the human AFP gene or a 1:1 ortholog thereof.		hp.json	alpha-1-fetoprotein|alpha-fetoglobulin|AFP|HPAFP	http://purl.obolibrary.org/obo/PR_000003809		
HP:0011212	biolink:PhenotypicFeature	EEG with photoparoxysmal response grade II	Occurence of epileptiform discharges in occipital and central regions during photic stimulation.	UMLS:C4023463	hp.json		http://purl.obolibrary.org/obo/HP_0011212		
HP:0011213	biolink:PhenotypicFeature	EEG with photoparoxysmal response grade III	Occurrence of epileptiform discharges in occipital, central, temporal and parietal regions during photic stimulation.	UMLS:C4023462	hp.json		http://purl.obolibrary.org/obo/HP_0011213		
HP:0011214	biolink:PhenotypicFeature	EEG with photoparoxysmal response grade IV	Occurrence of generalized epileptiform discharges during photic stimulation.	UMLS:C4023461	hp.json		http://purl.obolibrary.org/obo/HP_0011214		
HP:0011215	biolink:PhenotypicFeature	Hemihypsarrhythmia	Hypsarrhythmia occurring in one hemisphere.	UMLS:C4023460	hp.json		http://purl.obolibrary.org/obo/HP_0011215		
UBERON:0035881	biolink:AnatomicalEntity	ethmoidomaxillary suture	A suture between the orbital surface of the body of the maxilla with the orbital plate of the ethmoid bone.	FMA:52954	hp.json	sutura ethmoidomaxillaris|ethmoidomaxillary suture of skull	http://purl.obolibrary.org/obo/UBERON_0035881		
UBERON:0035883	biolink:AnatomicalEntity	lacrimomaxillary suture	A suture between the lacrimal bone and the maxilla.	FMA:52961	hp.json	lacrimomaxillary suture of skull|sutura lacrimomaxillaris	http://purl.obolibrary.org/obo/UBERON_0035883		
HP:0001888	biolink:PhenotypicFeature	Lymphopenia	A reduced number of lymphocytes in the blood.	UMLS:C0024312|SNOMEDCT_US:48813009|MSH:D008231	hp.json	Lymphocytopenia|Absolute lymphocyte count decrease|Decreased blood lymphocyte number|Low lymphocyte number	http://purl.obolibrary.org/obo/HP_0001888		
UBERON:0035882	biolink:AnatomicalEntity	sphenomaxillary suture	An inconstant suture between the pterygoid process of the sphenoid bone and the body of the maxilla.	FMA:52957	hp.json	sutura sphenomaxillaris|sphenomaxillary suture of skull	http://purl.obolibrary.org/obo/UBERON_0035882		
HP:0001889	biolink:PhenotypicFeature	Megaloblastic anemia	Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts).	MSH:D000749|SNOMEDCT_US:53165003|UMLS:C0002888	hp.json	Megaloblastic anaemia	http://purl.obolibrary.org/obo/HP_0001889		
UBERON:0035884	biolink:AnatomicalEntity	maxillary-premaxillary suture	A suture between the maxilla and premaxilla.		hp.json	incisive suture|premaxillary suture|maxillary-premaxillary incisive suture	http://purl.obolibrary.org/obo/UBERON_0035884		
HP:0001882	biolink:PhenotypicFeature	Leukopenia	An abnormal decreased number of leukocytes in the blood.	MSH:D007970|SNOMEDCT_US:84828003|UMLS:C0023530	hp.json	Low white blood cell count|Decreased blood leukocyte number	http://purl.obolibrary.org/obo/HP_0001882		
HP:0001883	biolink:PhenotypicFeature	Talipes	A deformity of foot and ankle that has different subtypes that are talipes equinovarus, talipes equinovalgus, talipes calcaneovarus and talipes calcaneovalgus.	SNOMEDCT_US:398309008|MSH:D000070558|UMLS:C1301937|UMLS:C3552713	hp.json	Talipes foot deformities	http://purl.obolibrary.org/obo/HP_0001883		
HP:0001880	biolink:PhenotypicFeature	Eosinophilia	Increased count of eosinophils in the blood.	MSH:D004802|UMLS:C0014457	hp.json	High blood eosinophil count	http://purl.obolibrary.org/obo/HP_0001880		
UBERON:0035879	biolink:AnatomicalEntity	frontomaxillary suture	A suture between the frontal bone and the frontal process of the maxilla.	FMA:52950	hp.json	frontomaxillary suture of skull|sutura frontomaxillaris	http://purl.obolibrary.org/obo/UBERON_0035879		
HP:0001881	biolink:PhenotypicFeature	Abnormal leukocyte morphology	An abnormality of leukocytes.	UMLS:C0152009|SNOMEDCT_US:24827003|SNOMEDCT_US:134199001	hp.json	Abnormality of leukocytes	http://purl.obolibrary.org/obo/HP_0001881		
HP:0001886	biolink:PhenotypicFeature	Foot osteomyelitis	An infection of bone of the foot.	UMLS:C4025737	hp.json	Foot bone infection	http://purl.obolibrary.org/obo/HP_0001886		
HP:0001884	biolink:PhenotypicFeature	Talipes calcaneovalgus	Talipes calcaneovalgus is a flexible foot deformity (as opposed to a rigid congenital vertical talus foot deformity) that can either present as a positional or structural foot deformity depending on severity and/or causality. The axis of calcaneovalgus deformity is in the tibiotalar joint, where the foot is positioned in extreme hyperextension. On inspection, the foot has an "up and out" appearance, with the dorsal forefoot practically touching the anterior aspect of the ankle and lower leg.	SNOMEDCT_US:205083002|UMLS:C0152237|SNOMEDCT_US:31668003|MSH:D005413	hp.json	Pes calcaneovarus	http://purl.obolibrary.org/obo/HP_0001884		
HP:0001885	biolink:PhenotypicFeature	Short 2nd toe	Underdevelopment (hypoplasia) of the second toe.	UMLS:C4021769	hp.json	Short second toe	http://purl.obolibrary.org/obo/HP_0001885		
HP:0011217	biolink:PhenotypicFeature	Abnormal shape of the occiput	An abnormal shape of occiput.	UMLS:C4023459	hp.json	Abnormal shape of the back of the head|Abnormal shape of posterior cranium|Abnormal shape of the back of the skull|Abnormal shape of posterior skull|Abnormal shape of posterior head	http://purl.obolibrary.org/obo/HP_0011217		
HP:0011218	biolink:PhenotypicFeature	Abnormal shape of the frontal region	An abnormal shape of the frontal part of the head.	UMLS:C4023458	hp.json	Dysmorphic frontal region|Abnormal morphology of the frontal region|Abnormal shape of the forehead|Dysmorphic forehead	http://purl.obolibrary.org/obo/HP_0011218		
HP:0011219	biolink:PhenotypicFeature	Short face	Facial height (length) is more than two standard deviations below the mean (objective); or an apparent decrease in the height (length) of the face (subjective).	UMLS:C4023457	hp.json	Decreased length of face|Vertical Facial Deficiency|Short facies|Vertical insufficiency of face|Short face|Vertical facial insufficiency|Decreased vertical dimension of face|Vertical shortening of face|Vertical deficiency of face|Vertical hypoplasia of face|Decreased height of face	http://purl.obolibrary.org/obo/HP_0011219		hposlim_core
HP:0011200	biolink:PhenotypicFeature	EEG with generalized polymorphic epileptiform discharges	Generalized epileptiform discharges of different shapes and frequencies.	UMLS:C4023474	hp.json	EEG with generalised polymorphic epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011200		
HP:0011201	biolink:PhenotypicFeature	EEG with changes in voltage	EEG with abnormal amplitude.	UMLS:C4023473	hp.json		http://purl.obolibrary.org/obo/HP_0011201		
HP:0011202	biolink:PhenotypicFeature	EEG with diffuse acceleration	EEG frequency is abnormally increased.	UMLS:C4023472	hp.json		http://purl.obolibrary.org/obo/HP_0011202		
HP:0011203	biolink:PhenotypicFeature	EEG with abnormally slow frequencies	EEG with abnormally slow frequencies.	UMLS:C4023471	hp.json		http://purl.obolibrary.org/obo/HP_0011203		
HP:0011204	biolink:PhenotypicFeature	EEG with continuous slow activity	EEG showing diffuse slowing without interruption.	UMLS:C4023470	hp.json		http://purl.obolibrary.org/obo/HP_0011204		
HP:0001899	biolink:PhenotypicFeature	Increased hematocrit	An elevation above the normal ratio of the volume of red blood cells to the total volume of blood.	UMLS:C0239935	hp.json	Increased Hct	http://purl.obolibrary.org/obo/HP_0001899		
HP:0001894	biolink:PhenotypicFeature	Thrombocytosis	Increased numbers of platelets in the peripheral blood.	SNOMEDCT_US:6631009|SNOMEDCT_US:415115007|MSH:D013922|UMLS:C0857460|UMLS:C0836924	hp.json	Increased platelet count|Thrombocythemia|Increased number of platelets in blood|Thrombocythaemia	http://purl.obolibrary.org/obo/HP_0001894		
HP:0001891	biolink:PhenotypicFeature	Iron deficiency anemia		UMLS:C0162316|SNOMEDCT_US:87522002|MSH:D018798	hp.json	Iron deficiency anaemia|Iron-deficiency anaemia|Iron-deficiency anemia|Ferropenic	http://purl.obolibrary.org/obo/HP_0001891		
HP:0001892	biolink:PhenotypicFeature	Abnormal bleeding	An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.	SNOMEDCT_US:64779008|SNOMEDCT_US:248250000|UMLS:C1458140	hp.json	Bleeding tendency|Hemorrhagic diathesis|Bleeding diathesis	http://purl.obolibrary.org/obo/HP_0001892		
HP:0001897	biolink:PhenotypicFeature	Normocytic anemia	A kind of anemia in which the volume of the red blood cells is normal.	UMLS:C0085577|SNOMEDCT_US:300980002	hp.json	Normocytic anaemia	http://purl.obolibrary.org/obo/HP_0001897		
HP:0001898	biolink:PhenotypicFeature	Increased red blood cell mass	The presence of an increased mass of red blood cells in the circulation.	UMLS:C1853288	hp.json	Increased RBC mass	http://purl.obolibrary.org/obo/HP_0001898		
HP:0001895	biolink:PhenotypicFeature	Normochromic anemia		UMLS:C0235983	hp.json	Normochromic anaemia	http://purl.obolibrary.org/obo/HP_0001895		
HP:0001896	biolink:PhenotypicFeature	Reticulocytopenia	A reduced number of reticulocytes in the peripheral blood.	UMLS:C0858867|SNOMEDCT_US:124961001	hp.json		http://purl.obolibrary.org/obo/HP_0001896		
HP:0011205	biolink:PhenotypicFeature	EEG with intermittent slow activity	Non-continuous diffuse slowing of electroencephalographic patterns.	UMLS:C4023469	hp.json		http://purl.obolibrary.org/obo/HP_0011205		
HP:0011206	biolink:PhenotypicFeature	EEG with generalized slow activity grade 1	Slowing at frequencies between 7.5 and 8.5 Hz.	UMLS:C4023468	hp.json	EEG with generalised slow activity grade 1	http://purl.obolibrary.org/obo/HP_0011206		
HP:0011207	biolink:PhenotypicFeature	EEG with generalized slow activity grade 2	Generalized slowing of EEG activity at frequencies between 4-7 Hz.	UMLS:C4023467	hp.json	EEG with generalised slow activity grade 2	http://purl.obolibrary.org/obo/HP_0011207		
HP:0011208	biolink:PhenotypicFeature	EEG with generalized slow activity grade 3	Generalized slowing of EEG activity at frequencies between 0.5-3 Hz.	UMLS:C4023466	hp.json	EEG with generalised slow activity grade 3	http://purl.obolibrary.org/obo/HP_0011208		
HP:0011209	biolink:PhenotypicFeature	EEG with generalized slow activity grade 4	EEG without electrical activity.	UMLS:C4021198	hp.json	EEG with generalised slow activity grade 4|Flat line EEG	http://purl.obolibrary.org/obo/HP_0011209		
OBO:HsapDv_0000092	biolink:NamedThing	human middle aged stage	Late adulthood that refers to an adult who is over 45 and under 65.		hp.json	45-64 years	http://purl.obolibrary.org/obo/HsapDv_0000092		
HP:0001890	biolink:PhenotypicFeature	Autoimmune hemolytic anemia	An autoimmune form of hemolytic anemia.	MSH:D000744|SNOMEDCT_US:413603009|UMLS:C0002880	hp.json	Autoimmune haemolytic anaemia|Hemolytic anemia, autoimmune|Autoimmune hemolytic anaemia	http://purl.obolibrary.org/obo/HP_0001890		
OBO:HsapDv_0000091	biolink:NamedThing	human late adulthood stage	Adult stage that refers to an adult who is over 45.		hp.json	Middle Aged + Aged|45+ years	http://purl.obolibrary.org/obo/HsapDv_0000091		
GO:0110116	biolink:BiologicalProcess	regulation of compound eye photoreceptor cell differentiation	Any process that modulates the frequency, rate or extent of compound eye photoreceptor cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0110116		
GO:0110111	biolink:BiologicalProcess	negative regulation of animal organ morphogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of animal organ morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_0110111		
GO:0110110	biolink:BiologicalProcess	positive regulation of animal organ morphogenesis	Any process that activates or increases the frequency, rate or extent of animal organ morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_0110110		
HP:0001868	biolink:PhenotypicFeature	Autoamputation of foot	Spontaneous detachment of a foot from the body.	UMLS:C4025740	hp.json		http://purl.obolibrary.org/obo/HP_0001868		
HP:0001869	biolink:PhenotypicFeature	Deep plantar creases	The presence of unusually deep creases (ridges/wrinkles) on the skin of sole of foot.	UMLS:C1857953	hp.json	Deep wrinkles in soles of feet	http://purl.obolibrary.org/obo/HP_0001869		
OBO:HsapDv_0000086	biolink:NamedThing	adolescent stage	Mature stage that refers to an adolescent who is over 13 and under 19 years old.		hp.json	13-18 years|teenager|teen	http://purl.obolibrary.org/obo/HsapDv_0000086		
OBO:HsapDv_0000083	biolink:NamedThing	infant stage	Immature stage that refers to an infant who is over 31 days and is under 24 months old.		hp.json	1-23 months|infantile stage	http://purl.obolibrary.org/obo/HsapDv_0000083		
OBO:HsapDv_0000089	biolink:NamedThing	young adult stage	Early adulthood that refers to an adult who is under 25.		hp.json	19-24 years	http://purl.obolibrary.org/obo/HsapDv_0000089		
HP:0001864	biolink:PhenotypicFeature	Clinodactyly of the 5th toe	Bending or curvature of a fifth toe in the tibial direction (i.e., towards the big toe).	UMLS:C4280586|UMLS:C4025741	hp.json	Curvature of the little toe|Curvature of the pinky toe|Curvature of the pinkie toe	http://purl.obolibrary.org/obo/HP_0001864		
OBO:HsapDv_0000087	biolink:NamedThing	human adult stage	Human developmental stage that refers to an adult who is over 19.		hp.json	19+ years	http://purl.obolibrary.org/obo/HsapDv_0000087		
HP:0001862	biolink:PhenotypicFeature	obsolete Acral ulceration and osteomyelitis leading to autoamputation of the digits (feet)			hp.json		http://purl.obolibrary.org/obo/HP_0001862		
OBO:HsapDv_0000088	biolink:NamedThing	human early adulthood stage	Adult stage that refers to an adult who is under 45.		hp.json	19-44 years	http://purl.obolibrary.org/obo/HsapDv_0000088		
HP:0001863	biolink:PhenotypicFeature	Toe clinodactyly	Bending or curvature of a toe in the tibial direction (i.e., towards the big toe).	UMLS:C4280587|UMLS:C4021770	hp.json	Toe curvature|Clinodactyly of feet	http://purl.obolibrary.org/obo/HP_0001863		
OBO:HsapDv_0000081	biolink:NamedThing	child stage	Immature stage that refers to child who is over 2 and under 13 years old.		hp.json	2-12 years	http://purl.obolibrary.org/obo/HsapDv_0000081		
OBO:HsapDv_0000082	biolink:NamedThing	newborn human stage	Immature stage that refers to a newborn who is under 32 days old.		hp.json	neonate|0-1 month|neonatal stage	http://purl.obolibrary.org/obo/HsapDv_0000082		
GO:0110117	biolink:BiologicalProcess	positive regulation of compound eye photoreceptor cell differentiation	Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0110117		
OBO:HsapDv_0000080	biolink:NamedThing	immature stage	Human developmental stage that covers the period from birth until 12 years old.	UBERON:0000112	hp.json	0-12 years|child	http://purl.obolibrary.org/obo/HsapDv_0000080		
GO:0110118	biolink:BiologicalProcess	negative regulation of compound eye photoreceptor cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0110118		
GO:0110124	biolink:BiologicalProcess	positive regulation of myotube cell migration	Any process that activates, maintains or increases the frequency, rate or extent of myotube cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0110124		
GO:0110125	biolink:BiologicalProcess	negative regulation of myotube cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0110125		
GO:0110122	biolink:BiologicalProcess	myotube cell migration	The orderly movement of a myotube cell from one site to another, often during the development of a multicellular organism. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate, and fuse.		hp.json		http://purl.obolibrary.org/obo/GO_0110122		
GO:0110123	biolink:BiologicalProcess	regulation of myotube cell migration	Any process that modulates the frequency, rate or extent of myotube cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0110123		
HP:0001879	biolink:PhenotypicFeature	Abnormal eosinophil morphology	An abnormal count or structure of eosinophils.	UMLS:C4025738	hp.json	Abnormality of eosinophils	http://purl.obolibrary.org/obo/HP_0001879		
HP:0001877	biolink:PhenotypicFeature	Abnormal erythrocyte morphology	Any structural abnormality of erythrocytes (red-blood cells).	SNOMEDCT_US:12222001|UMLS:C4020862|UMLS:C0391870	hp.json	Abnormality of red blood cells|Abnormality of erythroid lineage cell|Abnormality of erythrocytes	http://purl.obolibrary.org/obo/HP_0001877		
HP:0001878	biolink:PhenotypicFeature	Hemolytic anemia	A type of anemia caused by premature destruction of red blood cells (hemolysis).	MSH:D000743|UMLS:C0002878|SNOMEDCT_US:61261009	hp.json	Hemolytic anaemia|Haemolytic anaemia|Increased hemolysis	http://purl.obolibrary.org/obo/HP_0001878		
HP:0001871	biolink:PhenotypicFeature	Abnormality of blood and blood-forming tissues	An abnormality of the hematopoietic system.	UMLS:C4020864|SNOMEDCT_US:191124002|SNOMEDCT_US:34093004|UMLS:C0018939|UMLS:C0850715|MSH:D006402	hp.json	Hematologic disease|Abnormality of the haematopoietic system|Abnormality of the hematopoietic system|Haematological abnormality|Hematological abnormality|Abnormality of blood and blood-forming tissues	http://purl.obolibrary.org/obo/HP_0001871		
HP:0001872	biolink:PhenotypicFeature	Abnormality of thrombocytes	An abnormality of platelets.	MSH:D013915|UMLS:C4020863|SNOMEDCT_US:32942005|UMLS:C0151854|UMLS:C0040015|SNOMEDCT_US:127566005	hp.json	Thrombasthenia|Blood platelet disease|Platelet abnormalities	http://purl.obolibrary.org/obo/HP_0001872		
HP:0001870	biolink:PhenotypicFeature	Acroosteolysis of distal phalanges (feet)		UMLS:C4025739	hp.json	Acroosteolysis of distal phalanges of feet	http://purl.obolibrary.org/obo/HP_0001870		
HP:0001875	biolink:PhenotypicFeature	Neutropenia	An abnormally low number of neutrophils in the peripheral blood.	SNOMEDCT_US:165517008|UMLS:C0853697	hp.json	Peripheral neutropenia|Low blood neutrophil count|Neutropoenia|Low neutrophil count	http://purl.obolibrary.org/obo/HP_0001875		
HP:0001876	biolink:PhenotypicFeature	Pancytopenia	An abnormal reduction in numbers of all blood cell types (red blood cells, white blood cells, and platelets).	SNOMEDCT_US:127034005|UMLS:C0030312|MSH:D010198	hp.json	Low blood cell count|Pancytopaenia	http://purl.obolibrary.org/obo/HP_0001876		
HP:0001873	biolink:PhenotypicFeature	Thrombocytopenia	A reduction in the number of circulating thrombocytes.	SNOMEDCT_US:302215000|SNOMEDCT_US:415116008|MSH:D013921|UMLS:C0040034|UMLS:C0392386	hp.json	Low platelet count	http://purl.obolibrary.org/obo/HP_0001873		
HP:0001874	biolink:PhenotypicFeature	Abnormality of neutrophils	A neutrophil abnormality.	UMLS:C0427515|SNOMEDCT_US:250274006	hp.json	Abnormality of polymorphonuclear neutrophils|Abnormality of neutrophils|Abnormality of neutrophil	http://purl.obolibrary.org/obo/HP_0001874		
GO:1905651	biolink:BiologicalProcess	regulation of artery morphogenesis	Any process that modulates the frequency, rate or extent of artery morphogenesis.		hp.json	regulation of arterial morphogenesis|regulation of arteriogenesis	http://purl.obolibrary.org/obo/GO_1905651		
GO:1905652	biolink:BiologicalProcess	negative regulation of artery morphogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of artery morphogenesis.		hp.json	inhibition of artery morphogenesis|downregulation of arterial morphogenesis|down-regulation of artery morphogenesis|downregulation of arteriogenesis|down regulation of arterial morphogenesis|inhibition of arterial morphogenesis|down regulation of arteriogenesis|down-regulation of arterial morphogenesis|negative regulation of arterial morphogenesis|inhibition of arteriogenesis|negative regulation of arteriogenesis|down-regulation of arteriogenesis|downregulation of artery morphogenesis|down regulation of artery morphogenesis	http://purl.obolibrary.org/obo/GO_1905652		
UBERON:0011871	biolink:AnatomicalEntity	nasomaxillary suture	A cranial suture that connects a nasal bone and connects a maxilla.	FMA:52960	hp.json	nasomaxillary suture of skull|articulation of the nasal bone with maxilla	http://purl.obolibrary.org/obo/UBERON_0011871		
UBERON:0011865	biolink:AnatomicalEntity	corneal stroma collagen fibril	The connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011865		pheno_slim
UBERON:0008229	biolink:AnatomicalEntity	craniocervical region musculature	Musculature system of the pharyngeal and head regions.	ZFA:0000328|TAO:0000328|EMAPA:37259|MA:0000571	hp.json	head or neck muscle|head muscles|head or neck muscle	http://purl.obolibrary.org/obo/UBERON_0008229		
UBERON:0011864	biolink:AnatomicalEntity	tendon collagen fibril	The connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011864		pheno_slim
UBERON:0011869	biolink:AnatomicalEntity	pisiform joint		FMA:73126	hp.json	articulatio ossis pisiformis	http://purl.obolibrary.org/obo/UBERON_0011869		
GO:0002504	biolink:BiologicalProcess	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.		hp.json	peptide or polysaccharide antigen processing and presentation of via MHC class II	http://purl.obolibrary.org/obo/GO_0002504		
UBERON:0011863	biolink:AnatomicalEntity	bone collagen fibril	The connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011863		pheno_slim
UBERON:0011862	biolink:AnatomicalEntity	pulmonary collagen fibril	The connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011862		pheno_slim
UBERON:0011861	biolink:AnatomicalEntity	aorta collagen fibril	The connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity.		hp.json		http://purl.obolibrary.org/obo/UBERON_0011861		pheno_slim
UBERON:0011860	biolink:AnatomicalEntity	collection of collagen fibrils		FMA:63212|MESH:D024022|NIF_Subcellular:sao7547390221|NCIT:C32339	hp.json		http://purl.obolibrary.org/obo/UBERON_0011860		
GO:1905653	biolink:BiologicalProcess	positive regulation of artery morphogenesis	Any process that activates or increases the frequency, rate or extent of artery morphogenesis.		hp.json	up-regulation of arterial morphogenesis|up regulation of arteriogenesis|activation of arterial morphogenesis|upregulation of artery morphogenesis|up-regulation of arteriogenesis|activation of arteriogenesis|upregulation of arterial morphogenesis|up regulation of artery morphogenesis|upregulation of arteriogenesis|positive regulation of arterial morphogenesis|up-regulation of artery morphogenesis|activation of artery morphogenesis|up regulation of arterial morphogenesis|positive regulation of arteriogenesis	http://purl.obolibrary.org/obo/GO_1905653		
UBERON:0011856	biolink:AnatomicalEntity	acinus of lactiferous gland	An acinus that is part of a mammary gland.	FMA:74438	hp.json	lactiferous gland acinus	http://purl.obolibrary.org/obo/UBERON_0011856		
CHEBI:16449	biolink:ChemicalSubstance	alanine	An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	Gmelin:2449|PMID:17439666|Beilstein:635807|Reaxys:635807|Wikipedia:Alanine|CAS:302-72-7|Drug_Central:4306|KEGG:C01401|CAS:302-72-7|PMID:22264337|CAS:302-72-7	hp.json	2-aminopropanoic acid|2-Aminopropionic acid|ALA|Alanine|alanina|A|2-Aminopropanoic acid|Alanin|alanine	http://purl.obolibrary.org/obo/CHEBI_16449		3_STAR
UBERON:0011854	biolink:AnatomicalEntity	acinus of areolar gland	An acinus that is part of a areolar gland.	FMA:62081	hp.json	areolar gland acinus	http://purl.obolibrary.org/obo/UBERON_0011854		
UBERON:0035849	biolink:AnatomicalEntity	orbital margin	The mostly sharp edge of the orbital opening that is the peripheral border of the base of the pyramidal orbit.	FMA:53176	hp.json	margin of orbit|margo orbitalis|orbital rim	http://purl.obolibrary.org/obo/UBERON_0035849		
UBERON:0011859	biolink:AnatomicalEntity	internal acoustic meatus	The internal auditory meatus (also internal acoustic meatus, internal auditory canal, and internal acoustic canal) is a canal in the petrous bone of the temporal bone of the skull that carries nerves from inside the cranium towards the middle and inner ear compartments namely cranial nerve VII and cranial nerve VIII.	FMA:53163|NCIT:C95443|UMLS:C0149591	hp.json	internal auditory canal|internal acoustic meatus|porus acusticus internus|internal acoustic canal|internal auditory meatus	http://purl.obolibrary.org/obo/UBERON_0011859		pheno_slim
UBERON:0011858	biolink:AnatomicalEntity	acinus of exocrine gland	An acinus that is part of a exocrine gland.		hp.json	exocrine gland acinus	http://purl.obolibrary.org/obo/UBERON_0011858		
UBERON:0011857	biolink:AnatomicalEntity	acinus of lacrimal gland	An acinus that is part of a lacrimal gland.	FMA:85250	hp.json	lacrimal gland acinus	http://purl.obolibrary.org/obo/UBERON_0011857		
UBERON:0023879	biolink:AnatomicalEntity	neural system	A set of neural structures that subserve a specific function, e.g., visual system.	NLXANAT:090802	hp.json	neural system	http://purl.obolibrary.org/obo/UBERON_0023879		
GO:1903008	biolink:BiologicalProcess	organelle disassembly	The disaggregation of an organelle into its constituent components.		hp.json	organelle degradation	http://purl.obolibrary.org/obo/GO_1903008		
GO:1905671	biolink:BiologicalProcess	regulation of lysosome organization	Any process that modulates the frequency, rate or extent of lysosome organization.		hp.json	regulation of lysosome organization and biogenesis|regulation of lysosome organisation	http://purl.obolibrary.org/obo/GO_1905671		
GO:2000647	biolink:BiologicalProcess	negative regulation of stem cell proliferation	Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_2000647		
GO:1905672	biolink:BiologicalProcess	negative regulation of lysosome organization	Any process that stops, prevents or reduces the frequency, rate or extent of lysosome organization.		hp.json	down regulation of lysosome organization|downregulation of lysosome organization and biogenesis|inhibition of lysosome organization|downregulation of lysosome organization|down regulation of lysosome organization and biogenesis|negative regulation of lysosome organisation|down-regulation of lysosome organisation|negative regulation of lysosome organization and biogenesis|down-regulation of lysosome organization and biogenesis|down regulation of lysosome organisation|downregulation of lysosome organisation|inhibition of lysosome organisation|down-regulation of lysosome organization|inhibition of lysosome organization and biogenesis	http://purl.obolibrary.org/obo/GO_1905672		
GO:2000648	biolink:BiologicalProcess	positive regulation of stem cell proliferation	Any process that activates or increases the frequency, rate or extent of stem cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_2000648		
GO:1905673	biolink:BiologicalProcess	positive regulation of lysosome organization	Any process that activates or increases the frequency, rate or extent of lysosome organization.		hp.json	up regulation of lysosome organization and biogenesis|up regulation of lysosome organisation|up-regulation of lysosome organization and biogenesis|activation of lysosome organisation|positive regulation of lysosome organisation|up-regulation of lysosome organization|upregulation of lysosome organisation|up regulation of lysosome organization|activation of lysosome organization and biogenesis|activation of lysosome organization|upregulation of lysosome organization and biogenesis|positive regulation of lysosome organization and biogenesis|upregulation of lysosome organization|up-regulation of lysosome organisation	http://purl.obolibrary.org/obo/GO_1905673		
UBERON:0011850	biolink:AnatomicalEntity	acinus of salivary gland	An acinus that is part of a salivary gland.	FMA:59870	hp.json	salivary gland acinus	http://purl.obolibrary.org/obo/UBERON_0011850		
GO:1903012	biolink:BiologicalProcess	positive regulation of bone development	Any process that activates or increases the frequency, rate or extent of bone development.		hp.json	up regulation of bone development|up-regulation of bone development|activation of bone development|upregulation of bone development	http://purl.obolibrary.org/obo/GO_1903012		
UBERON:0011845	biolink:AnatomicalEntity	duct of sebaceous gland	A duct that is part of a sebaceous gland.	FMA:70947|NCIT:C33520	hp.json	sebaceous gland duct	http://purl.obolibrary.org/obo/UBERON_0011845		
PR:000050175	biolink:Protein	immunoglobulin light chain protein	A protein that is a translation product of some mRNA produced by a somatically recombined immunoglobulin light chain locus.		hp.json	IgL	http://purl.obolibrary.org/obo/PR_000050175		
PR:000050174	biolink:Protein	immunoglobulin heavy chain protein	A protein that is a translation product of some mRNA produced by a somatically recombined immunoglobulin heavy chain locus.		hp.json	IgH	http://purl.obolibrary.org/obo/PR_000050174		
GO:1903011	biolink:BiologicalProcess	negative regulation of bone development	Any process that stops, prevents or reduces the frequency, rate or extent of bone development.		hp.json	downregulation of bone development|down regulation of bone development|inhibition of bone development|down-regulation of bone development	http://purl.obolibrary.org/obo/GO_1903011		
GO:1903010	biolink:BiologicalProcess	regulation of bone development	Any process that modulates the frequency, rate or extent of bone development.		hp.json		http://purl.obolibrary.org/obo/GO_1903010		
PR:000050171	biolink:Protein	IgD immunoglobulin complex, circulating (human)	An IgD immunoglobulin complex, circulating in human. Circulating IgD is composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains (kappa or lambda), held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json	hIgD/circulating|IgD antibody (human)	http://purl.obolibrary.org/obo/PR_000050171		
OBO:HsapDv_0000045	biolink:NamedThing	prenatal stage	Prenatal stage that starts with fertilization and ends at birth.	UBERON:0000068	hp.json		http://purl.obolibrary.org/obo/HsapDv_0000045		
UBERON:0011847	biolink:AnatomicalEntity	acinus of parotid gland	An acinus that is part of a parotid gland.	FMA:59863|EMAPA:37933	hp.json	parotid gland acinus	http://purl.obolibrary.org/obo/UBERON_0011847		pheno_slim
UBERON:0011846	biolink:AnatomicalEntity	acinus of sebaceous gland	An acinus that is part of a sebaceous gland.	FMA:59657	hp.json	sebaceous gland acinus	http://purl.obolibrary.org/obo/UBERON_0011846		
CHEBI:41402	biolink:ChemicalSubstance	carboxymethyl group		PDBeChem:ACY	hp.json	aspartic acid side-chain|CARBOXYMETHYL GROUP|-CH2-COOH|carboxymethyl	http://purl.obolibrary.org/obo/CHEBI_41402		3_STAR
GO:0051493	biolink:BiologicalProcess	regulation of cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.		hp.json	regulation of cytoskeleton organisation|regulation of cytoskeleton organization and biogenesis	http://purl.obolibrary.org/obo/GO_0051493		
UBERON:0008200	biolink:AnatomicalEntity	forehead	The part of the face above the eyes[MESH]. In human anatomy, the forehead is the fore part of the head. It is, formally, an area of the head bounded by three features, two of the skull and one of the scalp. The top of the forehead is marked by the hairline, the edge of the area where hair on the scalp grows. The bottom of the forehead is marked by the supraorbital ridge, the bone feature of the skull above the eyes. The two sides of the forehead are marked by the temporal ridge, a bone feature that links the supraorbital ridge to the coronal suture line and beyond[WP].	UMLS:C0016540|GAID:74|NCIT:C89803|EMAPA:37869|galen:Forehead|FMA:63864|MESH:D005546	hp.json	fore head|sinciput	http://purl.obolibrary.org/obo/UBERON_0008200		pheno_slim
UBERON:0008202	biolink:AnatomicalEntity	bone of hip region		MA:0000655|EMAPA:37308|FMA:42854	hp.json		http://purl.obolibrary.org/obo/UBERON_0008202		pheno_slim|non_informative|grouping_class
GO:0051494	biolink:BiologicalProcess	negative regulation of cytoskeleton organization	Any process that stops, prevents, or reduces the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.		hp.json	down regulation of cytoskeleton organization|inhibition of cytoskeleton organization|downregulation of cytoskeleton organization|negative regulation of cytoskeleton organisation|negative regulation of cytoskeleton organization and biogenesis|down-regulation of cytoskeleton organization	http://purl.obolibrary.org/obo/GO_0051494		
GO:0051495	biolink:BiologicalProcess	positive regulation of cytoskeleton organization	Any process that activates or increases the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.		hp.json	positive regulation of cytoskeleton organization and biogenesis|up-regulation of cytoskeleton organization|positive regulation of cytoskeleton organisation|up regulation of cytoskeleton organization|activation of cytoskeleton organization|stimulation of cytoskeleton organization|upregulation of cytoskeleton organization	http://purl.obolibrary.org/obo/GO_0051495		
UBERON:0008203	biolink:AnatomicalEntity	pelvic cavity	The part of the ventral body cavity that is within the pelvis.	MA:0003089|EMAPA:37235|FMA:9738|SCTID:281903009|Wikipedia:Pelvic_cavity	hp.json	space of pelvic compartment|cavitas pelvis|cavitas pelvis	http://purl.obolibrary.org/obo/UBERON_0008203		
PR:P01101	biolink:Protein	protein c-Fos (mouse)	A protein c-Fos that is encoded in the genome of mouse.	UniProtKB:P01101	hp.json	Fos|FBJ osteosarcoma oncogene (mouse)|cellular oncogene fos (mouse)|mFOS|transcription factor AP-1 subunit c-Fos (mouse)	http://purl.obolibrary.org/obo/PR_P01101		
GO:1903019	biolink:BiologicalProcess	negative regulation of glycoprotein metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of glycoprotein metabolic process.		hp.json	downregulation of glycoprotein metabolic process|down-regulation of glycoprotein metabolism|negative regulation of glycoprotein metabolism|down regulation of glycoprotein metabolic process|inhibition of glycoprotein metabolic process|down regulation of glycoprotein metabolism|down-regulation of glycoprotein metabolic process|inhibition of glycoprotein metabolism|downregulation of glycoprotein metabolism	http://purl.obolibrary.org/obo/GO_1903019		
GO:1903018	biolink:BiologicalProcess	regulation of glycoprotein metabolic process	Any process that modulates the frequency, rate or extent of glycoprotein metabolic process.		hp.json	regulation of glycoprotein metabolism	http://purl.obolibrary.org/obo/GO_1903018		
OBO:HsapDv_0000037	biolink:NamedThing	fetal stage	Prenatal stage that starts with the fully formed embryo and ends at birth.	UBERON:0007220|EV:0300011	hp.json	foetus stage|fetus stage|second and third trimester	http://purl.obolibrary.org/obo/HsapDv_0000037		
PR:000050186	biolink:Protein	IgD heavy chain protein	An immunoglobulin heavy chain protein in which the constant region is encoded by the IgD gene segment.		hp.json	IgHD|immunoglobulin heavy chain delta|immunoglobulin delta heavy chain|immunoglobulin D heavy chain	http://purl.obolibrary.org/obo/PR_000050186		
PR:000050185	biolink:Protein	Ig lambda light chain protein (human)	An Ig lambda light chain protein that is encoded in the genome of human.		hp.json	hIgLambda	http://purl.obolibrary.org/obo/PR_000050185		
PR:000050184	biolink:Protein	Ig kappa light chain protein (human)	An Ig kappa light chain protein that is encoded in the genome of human.		hp.json	hIgKappa	http://purl.obolibrary.org/obo/PR_000050184		
GO:1903020	biolink:BiologicalProcess	positive regulation of glycoprotein metabolic process	Any process that activates or increases the frequency, rate or extent of glycoprotein metabolic process.		hp.json	upregulation of glycoprotein metabolic process|up-regulation of glycoprotein metabolism|up regulation of glycoprotein metabolism|up regulation of glycoprotein metabolic process|activation of glycoprotein metabolism|positive regulation of glycoprotein metabolism|up-regulation of glycoprotein metabolic process|activation of glycoprotein metabolic process|upregulation of glycoprotein metabolism	http://purl.obolibrary.org/obo/GO_1903020		
PR:000050183	biolink:Protein	immunoglobulin light chain protein (human)	An immunoglobulin light chain protein that is encoded in the genome of human.		hp.json	hIgL	http://purl.obolibrary.org/obo/PR_000050183		
PR:000050182	biolink:Protein	Ig lambda light chain protein	An immunoglobulin light chain protein that is produced from the immunoglobulin lambda locus.		hp.json	IgLambda	http://purl.obolibrary.org/obo/PR_000050182		
PR:000050181	biolink:Protein	Ig kappa light chain protein	An immunoglobulin light chain protein that is produced from the immunoglobulin kappa locus.		hp.json	IgKappa	http://purl.obolibrary.org/obo/PR_000050181		
PR:000050187	biolink:Protein	IgD heavy chain protein (human)	An IgD heavy chain protein that is encoded in the genome of human.		hp.json	hIgHD|immunoglobulin heavy chain delta (human)|immunoglobulin delta heavy chain (human)|immunoglobulin D heavy chain (human)	http://purl.obolibrary.org/obo/PR_000050187		
HP:0001808	biolink:PhenotypicFeature	Fragile nails	Nails that easily break.	UMLS:C1856963	hp.json	Brittle nails	http://purl.obolibrary.org/obo/HP_0001808		
HP:0001809	biolink:PhenotypicFeature	Split nail	A nail plate that has a longitudinal separation and the two sections of the nail share the same lateral radius of curvature.	SNOMEDCT_US:85136002|UMLS:C0263530	hp.json	Longitudinal splitting of nail	http://purl.obolibrary.org/obo/HP_0001809		
HP:0001802	biolink:PhenotypicFeature	Absent toenail	Congenital absence of the toenail.	UMLS:C1844555	hp.json	Anonychia of toenails|Absent toenail|Absent toenails (anonychia)|Absent toenails	http://purl.obolibrary.org/obo/HP_0001802		hposlim_core
HP:0001803	biolink:PhenotypicFeature	Nail pits	Small (typically about 1 mm or less in size) depressions on the dorsal nail surface.	SNOMEDCT_US:89704006|MEDDRA:10028702|UMLS:C0150993	hp.json	Nail pits|Nail pitting|Pitted nails	http://purl.obolibrary.org/obo/HP_0001803		secondary_consequence
GO:1905690	biolink:BiologicalProcess	nucleus disassembly	The disaggregation of a nucleus into its constituent components.		hp.json	cell nucleus disassembly	http://purl.obolibrary.org/obo/GO_1905690		
HP:0001800	biolink:PhenotypicFeature	Hypoplastic toenails	Underdevelopment of the toenail.	UMLS:C1837279	hp.json	Underdeveloped toenails	http://purl.obolibrary.org/obo/HP_0001800		
HP:0001806	biolink:PhenotypicFeature	Onycholysis	Detachment of the nail from the nail bed.	MEDDRA:10030337|MSH:D054039|SNOMEDCT_US:75789001|UMLS:C0085661	hp.json	Detachment of nail|Oncholysis	http://purl.obolibrary.org/obo/HP_0001806		hposlim_core
HP:0001807	biolink:PhenotypicFeature	Ridged nail	Longitudinal, linear prominences in the nail plate.	UMLS:C0423820|SNOMEDCT_US:271768001	hp.json	Nail ridging|Ridged nails|Longitudinal ridging|Grooved nails	http://purl.obolibrary.org/obo/HP_0001807		hposlim_core
HP:0001804	biolink:PhenotypicFeature	Hypoplastic fingernail	Underdevelopment of a fingernail.	UMLS:C1856786	hp.json	Underdeveloped fingernail|Small fingernail	http://purl.obolibrary.org/obo/HP_0001804		
HP:0001805	biolink:PhenotypicFeature	Onychogryposis	Nail that appears thick when viewed on end.	SNOMEDCT_US:52897009|UMLS:C0263537	hp.json	Thickened nails|Dystrophic thickened nails|Thick nail	http://purl.obolibrary.org/obo/HP_0001805		
GO:1903034	biolink:BiologicalProcess	regulation of response to wounding	Any process that modulates the frequency, rate or extent of response to wounding.		hp.json	regulation of physiological response to wounding	http://purl.obolibrary.org/obo/GO_1903034		
UBERON:0008266	biolink:AnatomicalEntity	periodontal ligament	The fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone. It extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket[BTO].	MA:0002467|GAID:1259|EMAPA:35679|FMA:56665|CALOHA:TS-0763|BTO:0001020|MESH:D010513	hp.json	alveolar periosteum|periodontal fibre|periodontium|PDL|peridontal fibre|peridontal ligament fiber|desmodontium|alveolodental ligament|peridontal ligament|periodontal fiber|peridontal membrane|paradentium|alveolodental membrane|peridontal fiber|odontoperiosteum|fibra periodontalis|peridental membrane|peridontium|peridontal ligament fibre	http://purl.obolibrary.org/obo/UBERON_0008266		pheno_slim
HP:0001814	biolink:PhenotypicFeature	Deep-set nails	Deeply placed nails.	UMLS:C3277753	hp.json	Deep-set nails	http://purl.obolibrary.org/obo/HP_0001814		
GO:1903039	biolink:BiologicalProcess	positive regulation of leukocyte cell-cell adhesion	Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion.		hp.json	up regulation of leukocyte adhesion|up-regulation of leukocyte cell-cell adhesion|activation of leukocyte cell-cell adhesion|up-regulation of leukocyte cell adhesion|up-regulation of leukocyte adhesion|up regulation of leukocyte cell adhesion|activation of leukocyte adhesion|activation of leukocyte cell adhesion|positive regulation of leukocyte cell adhesion|upregulation of leukocyte cell-cell adhesion|upregulation of leukocyte cell adhesion|upregulation of leukocyte adhesion|up regulation of leukocyte cell-cell adhesion|positive regulation of leukocyte adhesion	http://purl.obolibrary.org/obo/GO_1903039		
HP:0001812	biolink:PhenotypicFeature	Hyperconvex fingernails	When viewed on end (with the finger tip pointing toward the examiner's eye) the curve of the fingernail forms a tighter curve of convexity.	UMLS:C1844825	hp.json	Tubular fingernails	http://purl.obolibrary.org/obo/HP_0001812		
GO:1903038	biolink:BiologicalProcess	negative regulation of leukocyte cell-cell adhesion	Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion.		hp.json	downregulation of leukocyte cell-cell adhesion|inhibition of leukocyte cell adhesion|downregulation of leukocyte cell adhesion|downregulation of leukocyte adhesion|down regulation of leukocyte cell-cell adhesion|inhibition of leukocyte cell-cell adhesion|down-regulation of leukocyte cell-cell adhesion|down regulation of leukocyte adhesion|inhibition of leukocyte adhesion|down-regulation of leukocyte cell adhesion|negative regulation of leukocyte cell adhesion|negative regulation of leukocyte adhesion|down-regulation of leukocyte adhesion|down regulation of leukocyte cell adhesion	http://purl.obolibrary.org/obo/GO_1903038		
HP:0001817	biolink:PhenotypicFeature	Absent fingernail	Absence of a fingernail.	UMLS:C1844554	hp.json	Aplasia of the fingernail|Absent fingernail|Anonychia of fingernails	http://purl.obolibrary.org/obo/HP_0001817		hposlim_core
HP:0001818	biolink:PhenotypicFeature	Paronychia	The nail disease paronychia is an often-tender bacterial or fungal hand infection or foot infection where the nail and skin meet at the side or the base of a finger or toenail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia).	SNOMEDCT_US:71906005|MSH:D010304|UMLS:C0030578|MEDDRA:10034016	hp.json		http://purl.obolibrary.org/obo/HP_0001818		hposlim_core
GO:1903037	biolink:BiologicalProcess	regulation of leukocyte cell-cell adhesion	Any process that modulates the frequency, rate or extent of leukocyte cell-cell adhesion.		hp.json	regulation of leukocyte adhesion|regulation of leukocyte cell adhesion	http://purl.obolibrary.org/obo/GO_1903037		
GO:1903036	biolink:BiologicalProcess	positive regulation of response to wounding	Any process that activates or increases the frequency, rate or extent of response to wounding.		hp.json	upregulation of response to wounding|upregulation of physiological response to wounding|positive regulation of physiological response to wounding|up regulation of response to wounding|up regulation of physiological response to wounding|up-regulation of response to wounding|up-regulation of physiological response to wounding|activation of response to wounding|activation of physiological response to wounding	http://purl.obolibrary.org/obo/GO_1903036		
GO:1903035	biolink:BiologicalProcess	negative regulation of response to wounding	Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding.		hp.json	down regulation of physiological response to wounding|inhibition of response to wounding|inhibition of physiological response to wounding|down-regulation of response to wounding|down-regulation of physiological response to wounding|negative regulation of physiological response to wounding|downregulation of response to wounding|downregulation of physiological response to wounding|down regulation of response to wounding	http://purl.obolibrary.org/obo/GO_1903035		
HP:0001816	biolink:PhenotypicFeature	Thin nail	Nail that appears thin when viewed on end.	SNOMEDCT_US:63829008|UMLS:C0423823	hp.json	Thin nail|Thin nails	http://purl.obolibrary.org/obo/HP_0001816		hposlim_core
GO:1903045	biolink:BiologicalProcess	neural crest cell migration involved in sympathetic nervous system development	Any neural crest cell migration that is involved in sympathetic nervous system development.		hp.json		http://purl.obolibrary.org/obo/GO_1903045		
UBERON:0011899	biolink:AnatomicalEntity	epimysium	Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous.	UMLS:C0504096|Wikipedia:Epimysium|FMA:9726|NCIT:C32527	hp.json	fascia of muscle organ|epimysia|epimysia	http://purl.obolibrary.org/obo/UBERON_0011899		
UBERON:0035805	biolink:AnatomicalEntity	muscle layer of sigmoid colon	A muscle layer that is part of the sigmoid colon.	FMA:15028	hp.json	sigmoideum muscularis|sigmoid colon muscularis propria|muscularis propria of sigmoid colon|tunica muscularis colon sigmoideum|muscularis externa of sigmoid colon	http://purl.obolibrary.org/obo/UBERON_0035805		
UBERON:0035804	biolink:AnatomicalEntity	future mouth	The primordial mouth region of the developing head.	FMA:293105	hp.json	primitive mouth|primordial mouth	http://purl.obolibrary.org/obo/UBERON_0035804		
HP:0001810	biolink:PhenotypicFeature	Dystrophic toenail	Toenail changes apart from changes of the color of the toenail (nail dyschromia) that involve partial or complete disruption of the various keratinous layers of the nail plate.	UMLS:C1833225	hp.json	Poor toenail formation|Dystrophic toenails|Dystrophic toenail changes	http://purl.obolibrary.org/obo/HP_0001810		
UBERON:0035809	biolink:AnatomicalEntity	serous cavity		FMA:12241|SCTID:304404008	hp.json		http://purl.obolibrary.org/obo/UBERON_0035809		
UBERON:0008255	biolink:AnatomicalEntity	right clavicle	A clavicle that is in the right side of a entire appendicular skeleton.	FMA:13322	hp.json		http://purl.obolibrary.org/obo/UBERON_0008255		
UBERON:0008256	biolink:AnatomicalEntity	left clavicle	A clavicle that is in the left side of a entire appendicular skeleton.	FMA:13323	hp.json		http://purl.obolibrary.org/obo/UBERON_0008256		
GO:2000609	biolink:NamedThing	regulation of thyroid hormone generation			hp.json		http://purl.obolibrary.org/obo/GO_2000609		
UBERON:0011892	biolink:AnatomicalEntity	anterior uvea	Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris.	EMAPA:37417|SCTID:280656002	hp.json	ciliary body and iris|anterior vascular tunic of the eye|vasculosa oculi|Haller tunica vascula|anterior part of uveal tract|anterior vascular layer of the eyeball|ventral uveal tract|anterior uveal tract|tunica vasculosa bulbosa	http://purl.obolibrary.org/obo/UBERON_0011892		pheno_slim
GO:1903047	biolink:BiologicalProcess	mitotic cell cycle process	A process that is part of the mitotic cell cycle.		hp.json		http://purl.obolibrary.org/obo/GO_1903047		gocheck_do_not_annotate
UBERON:0011894	biolink:AnatomicalEntity	lumen of vagina	An organ cavity that is part of a vagina.	FMA:19982	hp.json	vaginal lumen	http://purl.obolibrary.org/obo/UBERON_0011894		
GO:1903046	biolink:BiologicalProcess	meiotic cell cycle process	A process that is part of the meiotic cell cycle.		hp.json		http://purl.obolibrary.org/obo/GO_1903046		gocheck_do_not_annotate|goslim_pombe
UBERON:0035820	biolink:AnatomicalEntity	peritoneal sac	A serous sac that is the aggregate of the peritoneum and the peritoneal cavity, located in the abdominal cavity.	EMAPA:16137|MA:0000054|FMA:9908	hp.json	peritoneal component	http://purl.obolibrary.org/obo/UBERON_0035820		
GO:1903056	biolink:BiologicalProcess	regulation of melanosome organization	Any process that modulates the frequency, rate or extent of melanosome organization.		hp.json	regulation of melanosome organization and biogenesis|regulation of melanosome organisation	http://purl.obolibrary.org/obo/GO_1903056		
GO:1903055	biolink:BiologicalProcess	positive regulation of extracellular matrix organization	Any process that activates or increases the frequency, rate or extent of extracellular matrix organization.		hp.json	up regulation of extracellular matrix organization and biogenesis|up-regulation of extracellular matrix organisation|upregulation of extracellular matrix organization|up-regulation of extracellular matrix organization and biogenesis|up regulation of extracellular matrix organisation|activation of extracellular matrix organisation|positive regulation of extracellular matrix organisation|activation of extracellular matrix organization and biogenesis|up-regulation of extracellular matrix organization|upregulation of extracellular matrix organization and biogenesis|upregulation of extracellular matrix organisation|up regulation of extracellular matrix organization|positive regulation of extracellular matrix organization and biogenesis|activation of extracellular matrix organization	http://purl.obolibrary.org/obo/GO_1903055		
GO:1903054	biolink:BiologicalProcess	negative regulation of extracellular matrix organization	Any process that stops, prevents or reduces the frequency, rate or extent of extracellular matrix organization.		hp.json	down-regulation of extracellular matrix organization|inhibition of extracellular matrix organisation|downregulation of extracellular matrix organisation|downregulation of extracellular matrix organization and biogenesis|down regulation of extracellular matrix organization|down regulation of extracellular matrix organization and biogenesis|downregulation of extracellular matrix organization|inhibition of extracellular matrix organization|negative regulation of extracellular matrix organization and biogenesis|down-regulation of extracellular matrix organization and biogenesis|negative regulation of extracellular matrix organisation|down-regulation of extracellular matrix organisation|inhibition of extracellular matrix organization and biogenesis|down regulation of extracellular matrix organisation	http://purl.obolibrary.org/obo/GO_1903054		
UBERON:0035814	biolink:AnatomicalEntity	pericardial fat	The sum of epicardial and paracardial fat deposits.	ZFA:0005765|SCTID:42267001	hp.json		http://purl.obolibrary.org/obo/UBERON_0035814		
GO:1903053	biolink:BiologicalProcess	regulation of extracellular matrix organization	Any process that modulates the frequency, rate or extent of extracellular matrix organization.		hp.json	regulation of extracellular matrix organisation|regulation of extracellular matrix organization and biogenesis	http://purl.obolibrary.org/obo/GO_1903053		
OBO:HsapDv_0000001	biolink:NamedThing	human life cycle	Temporal interval that defines human life from the prenatal stage until late adulthood.	UBERON:0000104	hp.json		http://purl.obolibrary.org/obo/HsapDv_0000001		
OBO:HsapDv_0000002	biolink:NamedThing	embryonic human stage	Prenatal stage that starts with fertilization and ends with a fully formed embryo, before undergoing last development during the fetal stage.	EV:0300001|FMA:72652	hp.json	embryo stage|first trimester	http://purl.obolibrary.org/obo/HsapDv_0000002		
UBERON:0035815	biolink:AnatomicalEntity	paracardial fat	Fat deposits in the mediastinum outside the parietal pericardium .		hp.json	intrathoracic fat|intrathoracic fat	http://purl.obolibrary.org/obo/UBERON_0035815		
UBERON:0035818	biolink:AnatomicalEntity	visceral fat	Any fat deposit surrounding a visceral organ.		hp.json		http://purl.obolibrary.org/obo/UBERON_0035818		
OBO:HsapDv_0000000	biolink:NamedThing	human life cycle stage	A spatiotemporal region encompassing some part of the life cycle of an organism.	UBERON:0000105	hp.json	developmental stage|stage	http://purl.obolibrary.org/obo/HsapDv_0000000		
UBERON:0035819	biolink:AnatomicalEntity	abdominopelvic cavity	The part of the ventral body cavity that is within the abdominal segment of the trunk, which encompasses the abdomen proper plus pelvic cavity.	FMA:12267|Wikipedia:Abdominopelvic_cavity	hp.json	cavitas abdominis et pelvis	http://purl.obolibrary.org/obo/UBERON_0035819		
UBERON:0008242	biolink:AnatomicalEntity	lower back muscle	A muscle of back that is part of a lower back.	MA:0000502|EMAPA:37262	hp.json		http://purl.obolibrary.org/obo/UBERON_0008242		
UBERON:0008243	biolink:AnatomicalEntity	upper back muscle	A muscle of back that is part of a dorsal thoracic segment of trunk.	EMAPA:37261|MA:0000508|SCTID:305071003	hp.json		http://purl.obolibrary.org/obo/UBERON_0008243		
OBO:cl#has_low_plasma_membrane_amount	biolink:NamedThing	has_low_plasma_membrane_amount	A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617).		hp.json		http://purl.obolibrary.org/obo/cl#has_low_plasma_membrane_amount		
GO:2000610	biolink:NamedThing	negative regulation of thyroid hormone generation			hp.json		http://purl.obolibrary.org/obo/GO_2000610		
GO:2000611	biolink:NamedThing	positive regulation of thyroid hormone generation			hp.json		http://purl.obolibrary.org/obo/GO_2000611		
GO:1903058	biolink:BiologicalProcess	positive regulation of melanosome organization	Any process that activates or increases the frequency, rate or extent of melanosome organization.		hp.json	up-regulation of melanosome organisation|upregulation of melanosome organization|activation of melanosome organization and biogenesis|upregulation of melanosome organization and biogenesis|up regulation of melanosome organisation|positive regulation of melanosome organisation|activation of melanosome organisation|positive regulation of melanosome organization and biogenesis|up-regulation of melanosome organization|up regulation of melanosome organization and biogenesis|upregulation of melanosome organisation|up regulation of melanosome organization|up-regulation of melanosome organization and biogenesis|activation of melanosome organization	http://purl.obolibrary.org/obo/GO_1903058		
GO:1903057	biolink:BiologicalProcess	negative regulation of melanosome organization	Any process that stops, prevents or reduces the frequency, rate or extent of melanosome organization.		hp.json	down-regulation of melanosome organization|downregulation of melanosome organisation|down-regulation of melanosome organization and biogenesis|negative regulation of melanosome organization and biogenesis|down regulation of melanosome organization|inhibition of melanosome organization and biogenesis|inhibition of melanosome organization|downregulation of melanosome organization|down-regulation of melanosome organisation|negative regulation of melanosome organisation|downregulation of melanosome organization and biogenesis|down regulation of melanosome organisation|down regulation of melanosome organization and biogenesis|inhibition of melanosome organisation	http://purl.obolibrary.org/obo/GO_1903057		
UBERON:0035831	biolink:AnatomicalEntity	costal diaphragm	The domain of the diaphragm that is a thin domed sheet of muscle composed of a radial array of myofibers extending laterally from the ribs and medially to a central tendon.	FMA:58277	hp.json	pars costalis diaphragmatis|costal part of diaphragm	http://purl.obolibrary.org/obo/UBERON_0035831		
UBERON:0011878	biolink:AnatomicalEntity	muscle layer of esophagus	A muscle layer that is part of a wall of esophagus.	FMA:62998	hp.json	tunica muscularis esophagi|muscular layer of oesophagus|muscle coat of esophagus|muscular coat of oesophagus|tela muscularis (oesophagus)|tunica muscularis oesophageae	http://purl.obolibrary.org/obo/UBERON_0011878		
UBERON:0011877	biolink:AnatomicalEntity	margin of tongue	The lateral border that separates the dorsum from the inferior surface of the tongue on each side, the two borders meeting anteriorly at the apex..	FMA:54650	hp.json	margo linguae|tongue margin	http://purl.obolibrary.org/obo/UBERON_0011877		
UBERON:0035825	biolink:AnatomicalEntity	left adrenal gland cortex	The thick outer layer of the adrenal gland that is in the left side of the abdomen.	FMA:69089	hp.json	cortex of left suprarenal gland|left adrenal cortex|cortex of left adrenal gland	http://purl.obolibrary.org/obo/UBERON_0035825		
UBERON:0011875	biolink:AnatomicalEntity	ligament of sternoclavicular joint	A skeletal ligament that is part of a sternoclavicular joint.	FMA:63980	hp.json	ligamentum sternoclavicularis|sternoclavicular joint ligament	http://purl.obolibrary.org/obo/UBERON_0011875		
UBERON:0035827	biolink:AnatomicalEntity	right adrenal gland cortex	The thick outer layer of the adrenal gland that is in the right side of the abdomen.	FMA:69088	hp.json	cortex of right suprarenal gland|cortex of right adrenal gland|right adrenal cortex	http://purl.obolibrary.org/obo/UBERON_0035827		
UBERON:0035826	biolink:AnatomicalEntity	left adrenal gland medulla	The adrenal gland medulla that is in the left side of the abdomen.	FMA:69092	hp.json	medulla of left suprarenal gland|left adrenal medulla|medulla of left adrenal gland	http://purl.obolibrary.org/obo/UBERON_0035826		
UBERON:0035828	biolink:AnatomicalEntity	right adrenal gland medulla	The adrenal gland medulla that is in the right side of the abdomen.	FMA:69091	hp.json	right adrenal medulla|medulla of right suprarenal gland|medulla of right adrenal gland	http://purl.obolibrary.org/obo/UBERON_0035828		
UBERON:0008230	biolink:AnatomicalEntity	tibialis	Either of two muscles of the calf of the leg.	MA:0002425|BTO:0000864|NCIT:C53076|EMAPA:35867|UMLS:C1710422	hp.json	tibialis muscle	http://purl.obolibrary.org/obo/UBERON_0008230		
UBERON:0008231	biolink:AnatomicalEntity	dorsal thoracic segment of trunk	Subdivision of thorax, which in humans is the posterior part of the thorax and is demarcated from the chest by the external surface of the posterolateral part of the rib cage and the anterior surface of the thoracic vertebral column; together with the chest, it constitutes the thorax.	MA:0000028|FMA:24217|SCTID:362666008|EMAPA:37234	hp.json	thoracic back|thoracic part of back|upper back|dorsum of thorax|posterior part of thorax|back of thorax	http://purl.obolibrary.org/obo/UBERON_0008231		
GO:0002468	biolink:BiologicalProcess	dendritic cell antigen processing and presentation	The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.		hp.json		http://purl.obolibrary.org/obo/GO_0002468		
GO:0002469	biolink:BiologicalProcess	myeloid dendritic cell antigen processing and presentation	The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.		hp.json		http://purl.obolibrary.org/obo/GO_0002469		
GO:0002460	biolink:BiologicalProcess	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus.		hp.json		http://purl.obolibrary.org/obo/GO_0002460		
CHEBI:90318	biolink:ChemicalSubstance	EC 6.4.1.1 (pyruvate carboxylase) inhibitor	An EC 6.4.1.* (carboxylase) inhibitor that interferes with the action of pyruvate carboxylase (EC 6.4.1.1).	Wikipedia:Pyruvate_carboxylase	hp.json	pyruvic carboxylase inhibitors|pyruvate carboxylase inhibitor|pyruvate:carbon-dioxide ligase (ADP-forming) inhibitors|EC 6.4.1.1 inhibitor|pyruvate carboxylase (EC 6.4.1.1) inhibitor|EC 6.4.1.1 inhibitors|pyruvate carboxylase (EC 6.4.1.1) inhibitors|EC 6.4.1.1 (pyruvate carboxylase) inhibitors|pyruvate:carbon-dioxide ligase (ADP-forming) inhibitor|pyruvate carboxylase inhibitors|pyruvic carboxylase inhibitor	http://purl.obolibrary.org/obo/CHEBI_90318		3_STAR
CHEBI:53368	biolink:ChemicalSubstance	ionic macromolecule	A macromolecule containing ionic groups.		hp.json	ionic polymer|polyionic macromolecule	http://purl.obolibrary.org/obo/CHEBI_53368		3_STAR
GO:0051402	biolink:BiologicalProcess	neuron apoptotic process	Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.		hp.json	neuronal cell apoptosis|apoptosis of neurons|programmed cell death of neuronal cells by apoptosis|programmed cell death, neuronal cells|programmed cell death of neurons by apoptosis|programmed cell death, neurons|apoptosis of neuronal cells|neuron apoptosis|neuron programmed cell death by apoptosis|neuronal cell programmed cell death by apoptosis	http://purl.obolibrary.org/obo/GO_0051402		
GO:0002471	biolink:BiologicalProcess	monocyte antigen processing and presentation	The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.		hp.json		http://purl.obolibrary.org/obo/GO_0002471		
GO:0002472	biolink:BiologicalProcess	macrophage antigen processing and presentation	The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.		hp.json		http://purl.obolibrary.org/obo/GO_0002472		
HP:0011197	biolink:PhenotypicFeature	EEG with focal spike waves	EEG with focal sharp transient waves of a duration less than 80 msec followed by a slow wave.	UMLS:C4023477	hp.json		http://purl.obolibrary.org/obo/HP_0011197		
GO:0002446	biolink:BiologicalProcess	neutrophil mediated immunity	Any process involved in the carrying out of an immune response by a neutrophil.		hp.json		http://purl.obolibrary.org/obo/GO_0002446		
HP:0011198	biolink:PhenotypicFeature	EEG with generalized epileptiform discharges	EEG discharges recorded on the entire scalp typically seen in persons with epilepsy.	UMLS:C4023476	hp.json	EEG with generalised epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011198		
HP:0011199	biolink:PhenotypicFeature	EEG with generalized sharp slow waves	EEG with generalized sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.	UMLS:C4023475	hp.json	EEG with generalised sharp slow waves	http://purl.obolibrary.org/obo/HP_0011199		
GO:0002442	biolink:BiologicalProcess	serotonin secretion involved in inflammatory response	The regulated release of serotonin by a cell as part of an inflammatory response.		hp.json	serotonin secretion involved in acute inflammatory response|serotonin release involved in inflammatory response	http://purl.obolibrary.org/obo/GO_0002442		
GO:0002443	biolink:BiologicalProcess	leukocyte mediated immunity	Any process involved in the carrying out of an immune response by a leukocyte.		hp.json	leucocyte immune effector process|leucocyte mediated immunity|immune cell mediated immunity|leukocyte immune effector process|immune cell effector process|cellular immune response|cell-mediated immune response	http://purl.obolibrary.org/obo/GO_0002443		
GO:0002444	biolink:BiologicalProcess	myeloid leukocyte mediated immunity	Any process involved in the carrying out of an immune response by a myeloid leukocyte.		hp.json	myeloid leukocyte immune effector process|myeloid leucocyte immune effector process|myeloid leucocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002444		
HP:0011190	biolink:PhenotypicFeature	Uni- and bilateral multifocal epileptiform discharges	Epileptiform discharges identified at multiple locations temporarily in both hemispheres and temporarily in one hemisphere.	UMLS:C4023484	hp.json		http://purl.obolibrary.org/obo/HP_0011190		
HP:0011191	biolink:PhenotypicFeature	Unilateral multifocal epileptiform discharges	Epileptiform discharges being identified at multiple locations in one hemisphere.	UMLS:C4023483	hp.json		http://purl.obolibrary.org/obo/HP_0011191		
GO:0002440	biolink:BiologicalProcess	production of molecular mediator of immune response	The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.		hp.json	production of cellular mediator of immune response	http://purl.obolibrary.org/obo/GO_0002440		gocheck_do_not_annotate
HP:0011192	biolink:PhenotypicFeature	Polymorphic focal epileptiform discharges	Focal epileptiform discharges of different shapes and frequencies.	UMLS:C4023482	hp.json		http://purl.obolibrary.org/obo/HP_0011192		
HP:0011193	biolink:PhenotypicFeature	EEG with focal spikes	EEG with focal sharp transient waves of a duration less than 80 msec.	UMLS:C4023481	hp.json		http://purl.obolibrary.org/obo/HP_0011193		
CHEBI:28384	biolink:ChemicalSubstance	vitamin K	Any member of a group of fat-soluble 2-methyl-1,4-napthoquinones that exhibit biological activity against vitamin K deficiency. Vitamin K is required for the synthesis of prothrombin and certain other blood coagulation factors.	CAS:12001-79-5|Wikipedia:Vitamin_K|CAS:12001-79-5|PMID:34109217|PMID:33255760|KEGG:C01628|PMID:26413183|MetaCyc:CPD-11501	hp.json	vitamin K vitamer|vitamine K|vitamin K vitamers|vitamins K|Vitamin K	http://purl.obolibrary.org/obo/CHEBI_28384		3_STAR
CHEBI:28383	biolink:ChemicalSubstance	alpha,omega-dicarboxylic acid		KEGG:C04025	hp.json	alpha,omega-Dicarboxylic acid|alpha(omega)-Dicarboxylic acid|alpha,omega-dicarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_28383		3_STAR
HP:0011194	biolink:PhenotypicFeature	EEG with series of focal spikes	Focal spikes occurring for several seconds.	UMLS:C4023480	hp.json		http://purl.obolibrary.org/obo/HP_0011194		
HP:0011195	biolink:PhenotypicFeature	EEG with focal sharp slow waves	EEG with focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave.	UMLS:C4023479	hp.json		http://purl.obolibrary.org/obo/HP_0011195		
HP:0011196	biolink:PhenotypicFeature	EEG with focal sharp waves	EEG with focal sharp transient waves of a duration between 80 and 200 msec.	UMLS:C4023478	hp.json		http://purl.obolibrary.org/obo/HP_0011196		
GO:0002449	biolink:BiologicalProcess	lymphocyte mediated immunity	Any process involved in the carrying out of an immune response by a lymphocyte.		hp.json	cellular immune response|cell-mediated immunity	http://purl.obolibrary.org/obo/GO_0002449		
HP:0011186	biolink:PhenotypicFeature	Focal epileptiform discharges with limited propagation to contralateral hemisphere	Focal epileptiform discharges with spreading to contralateral hemisphere but without secondary generalization.	UMLS:C4023488	hp.json		http://purl.obolibrary.org/obo/HP_0011186		
GO:0002456	biolink:BiologicalProcess	T cell mediated immunity	Any process involved in the carrying out of an immune response by a T cell.		hp.json	cellular immune response|T-cell mediated immunity|cell-mediated immunity|T lymphocyte mediated immunity|T-lymphocyte mediated immunity	http://purl.obolibrary.org/obo/GO_0002456		
HP:0011187	biolink:PhenotypicFeature	Focal EEG discharges with propagation to ipsilateral hemisphere	Focal epileptiform discharges with spreading to the hemisphere on the same side of the brain.	UMLS:C4023487	hp.json		http://purl.obolibrary.org/obo/HP_0011187		
GO:0002457	biolink:BiologicalProcess	T cell antigen processing and presentation	The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.		hp.json	T-cell antigen processing and presentation|T lymphocyte antigen processing and presentation|T-lymphocyte antigen processing and presentation	http://purl.obolibrary.org/obo/GO_0002457		
HP:0011188	biolink:PhenotypicFeature	Focal EEG discharges with secondary generalization	Focal EEG discharges that secondarily spread to both hemispheres and can then be recorded over the entire scalp.	UMLS:C4023486	hp.json	Focal EEG discharges with secondary generalisation	http://purl.obolibrary.org/obo/HP_0011188		
HP:0011189	biolink:PhenotypicFeature	Bilateral multifocal epileptiform discharges	Epileptiform discharges being identified at multiple locations in both hemispheres.	UMLS:C4023485	hp.json		http://purl.obolibrary.org/obo/HP_0011189		
HP:0011180	biolink:PhenotypicFeature	Partial beta-EEG	EEG dominated by diffuse beta waves (>13 Hz) with occipitally localized alpha waves (8-13 Hz).	UMLS:C4023492	hp.json		http://purl.obolibrary.org/obo/HP_0011180		
HP:0011181	biolink:PhenotypicFeature	Low voltage EEG	EEG with an amplitude less than 30 microvolts without observable occipital alpha rhythm (8-13 Hz).	UMLS:C1851759	hp.json		http://purl.obolibrary.org/obo/HP_0011181		
HP:0011182	biolink:PhenotypicFeature	Interictal epileptiform activity	Epileptiform activity refers to distinctive EEG waves or complexes distinguished from background activity found in in a proportion of human subjects with epilepsy, but which can also be found in subjects without seizures. Interictal epileptiform activity refers to such activity that occurs in the absence of a clinical or subclinical seizure.	UMLS:C4023491	hp.json	Epileptiform EEG discharges	http://purl.obolibrary.org/obo/HP_0011182		
HP:0011183	biolink:PhenotypicFeature	EEG with hyperventilation-induced focal epileptiform discharges	Focal epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).	UMLS:C4023490	hp.json		http://purl.obolibrary.org/obo/HP_0011183		
HP:0011184	biolink:PhenotypicFeature	EEG with hyperventilation-induced generalized epileptiform discharges	Generalized epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).	UMLS:C4023489	hp.json	EEG with hyperventilation-induced generalised epileptiform discharges	http://purl.obolibrary.org/obo/HP_0011184		
HP:0011185	biolink:PhenotypicFeature	EEG with focal epileptiform discharges	EEG discharges recorded in particular areas of a localized (focal) abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).	UMLS:C4021199	hp.json	Focal EEG Abnormality	http://purl.obolibrary.org/obo/HP_0011185		
GO:2000668	biolink:BiologicalProcess	regulation of dendritic cell apoptotic process	Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process.		hp.json	regulation of dendritic cell apoptosis	http://purl.obolibrary.org/obo/GO_2000668		
GO:2000669	biolink:BiologicalProcess	negative regulation of dendritic cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.		hp.json	negative regulation of dendritic cell apoptosis	http://purl.obolibrary.org/obo/GO_2000669		
UBERON:0008307	biolink:AnatomicalEntity	heart endothelium	An endothelium that is part of a heart [Automatically generated definition].	BTO:0004293	hp.json	cardiac endothelium	http://purl.obolibrary.org/obo/UBERON_0008307		
GO:1905606	biolink:BiologicalProcess	regulation of presynapse assembly	Any process that modulates the frequency, rate or extent of presynapse assembly.		hp.json	regulation of presynaptic terminal assembly|regulation of presynapse biogenesis	http://purl.obolibrary.org/obo/GO_1905606		goslim_synapse
GO:1905607	biolink:BiologicalProcess	negative regulation of presynapse assembly	Any process that stops, prevents or reduces the frequency, rate or extent of presynapse assembly.		hp.json	down-regulation of presynaptic terminal assembly|inhibition of presynapse biogenesis|negative regulation of presynaptic terminal assembly|downregulation of presynapse biogenesis|down regulation of presynaptic terminal assembly|down-regulation of presynapse assembly|inhibition of presynaptic terminal assembly|downregulation of presynaptic terminal assembly|down regulation of presynapse assembly|inhibition of presynapse assembly|negative regulation of presynapse biogenesis|down-regulation of presynapse biogenesis|downregulation of presynapse assembly|down regulation of presynapse biogenesis	http://purl.obolibrary.org/obo/GO_1905607		
GO:1905608	biolink:BiologicalProcess	positive regulation of presynapse assembly	Any process that activates or increases the frequency, rate or extent of presynapse assembly.		hp.json	activation of presynapse assembly|upregulation of presynaptic terminal assembly|up-regulation of presynapse biogenesis|upregulation of presynapse assembly|up regulation of presynapse biogenesis|activation of presynapse biogenesis|positive regulation of presynapse biogenesis|up-regulation of presynaptic terminal assembly|up regulation of presynaptic terminal assembly|upregulation of presynapse biogenesis|up-regulation of presynapse assembly|activation of presynaptic terminal assembly|positive regulation of presynaptic terminal assembly|up regulation of presynapse assembly	http://purl.obolibrary.org/obo/GO_1905608		
GO:0051445	biolink:BiologicalProcess	regulation of meiotic cell cycle	Any process that modulates the rate or extent of progression through the meiotic cell cycle.		hp.json	modulation of meiotic cell cycle progression|regulation of meiotic cell cycle progression|regulation of progression through meiotic cell cycle|meiotic cell cycle regulator|meiotic cell cycle modulation|meiotic cell cycle regulation	http://purl.obolibrary.org/obo/GO_0051445		
GO:0051446	biolink:BiologicalProcess	positive regulation of meiotic cell cycle	Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.		hp.json	up regulation of progression through meiotic cell cycle|stimulation of progression through meiotic cell cycle|positive regulation of progression through meiotic cell cycle|positive regulation of meiotic cell cycle progression|up-regulation of progression through meiotic cell cycle|activation of progression through meiotic cell cycle|upregulation of progression through meiotic cell cycle	http://purl.obolibrary.org/obo/GO_0051446		
GO:0051447	biolink:BiologicalProcess	negative regulation of meiotic cell cycle	Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.		hp.json	negative regulation of meiotic cell cycle progression|negative regulation of progression through meiotic cell cycle|downregulation of progression through meiotic cell cycle|down regulation of progression through meiotic cell cycle|inhibition of progression through meiotic cell cycle|down-regulation of progression through meiotic cell cycle	http://purl.obolibrary.org/obo/GO_0051447		
UBERON:0011932	biolink:AnatomicalEntity	pilosebaceous unit	An epidermal invagination that has as parts a hair follicle, a sebaceous gland, and arrector pili muscle.	FMA:70661|EMAPA:36582	hp.json	pilo-sebaceous unit|fabrica pilosebacea|pilo-sebaceous apparatus|pilosebaceous gland|pilosebaceous apparatus	http://purl.obolibrary.org/obo/UBERON_0011932		pheno_slim
UBERON:0011931	biolink:AnatomicalEntity	nasal hair	Hair in the nose.	FMA:53670	hp.json	hair of vestibular part of nose|nose hair|hair of nose	http://purl.obolibrary.org/obo/UBERON_0011931		pheno_slim
GO:2000670	biolink:BiologicalProcess	positive regulation of dendritic cell apoptotic process	Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process.		hp.json	positive regulation of dendritic cell apoptosis	http://purl.obolibrary.org/obo/GO_2000670		
GO:2000671	biolink:BiologicalProcess	regulation of motor neuron apoptotic process	Any process that modulates the frequency, rate or extent of motor neuron apoptotic process.		hp.json	regulation of motor neuron apoptosis|regulation of motoneuron apoptosis	http://purl.obolibrary.org/obo/GO_2000671		
PR:P15702	biolink:Protein	leukosialin (mouse)	A leukosialin that is encoded in the genome of mouse.	UniProtKB:P15702	hp.json	CD43 (mouse)|sialophorin (mouse)|B-cell differentiation antigen LP-3 (mouse)|mSPN|lymphocyte antigen 48 (mouse)|leukocyte sialoglycoprotein (mouse)|Spn|Ly-48 (mouse)	http://purl.obolibrary.org/obo/PR_P15702		
UBERON:0011930	biolink:AnatomicalEntity	preganglionic parasympathetic fiber	A cholinergic axonal fibers projecting from the CNS to a parasympathetic ganglion.	Wikipedia:Preganglionic_fibers	hp.json	parasympathetic preganglionic fiber	http://purl.obolibrary.org/obo/UBERON_0011930		
GO:2000672	biolink:BiologicalProcess	negative regulation of motor neuron apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.		hp.json	negative regulation of motor neuron apoptosis|negative regulation of motoneuron apoptosis	http://purl.obolibrary.org/obo/GO_2000672		
GO:2000673	biolink:BiologicalProcess	positive regulation of motor neuron apoptotic process	Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process.		hp.json	positive regulation of motor neuron apoptosis|positive regulation of motoneuron apoptosis	http://purl.obolibrary.org/obo/GO_2000673		
CHEBI:53309	biolink:ChemicalSubstance	polyanionic macromolecule	A polymer carrying multiple negative charges.		hp.json	polyanions|polyanion	http://purl.obolibrary.org/obo/CHEBI_53309		3_STAR
UBERON:0011922	biolink:AnatomicalEntity	cochlear basement membrane	The the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament ensheathing the root cell processes.	EMAPA:37830	hp.json	cochlea basement membrane|basement membrane of cochlear labyrinth	http://purl.obolibrary.org/obo/UBERON_0011922		pheno_slim
UBERON:0011921	biolink:AnatomicalEntity	connecting stalk blood islands		EHDAA2:0003242	hp.json	blood island of umbilical vesicle|insula sanguinea vesiculae umbilicalis	http://purl.obolibrary.org/obo/UBERON_0011921		
UBERON:0011925	biolink:AnatomicalEntity	preganglionic autonomic fiber	Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released.	FMA:5923|Wikipedia:Preganglionic_nerve_fibers|MESH:D001339|NCIT:C12624	hp.json	preganglionic autonomic fibre|preganglionic nerve fiber	http://purl.obolibrary.org/obo/UBERON_0011925		
GO:1905627	biolink:BiologicalProcess	regulation of serotonin biosynthetic process	Any process that modulates the frequency, rate or extent of serotonin biosynthetic process.		hp.json	regulation of serotonin anabolism|regulation of serotonin synthesis|regulation of serotonin formation|regulation of serotonin biosynthesis	http://purl.obolibrary.org/obo/GO_1905627		
GO:1905628	biolink:BiologicalProcess	negative regulation of serotonin biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of serotonin biosynthetic process.		hp.json	inhibition of serotonin biosynthetic process|inhibition of serotonin biosynthesis|negative regulation of serotonin biosynthesis|down-regulation of serotonin biosynthetic process|down-regulation of serotonin biosynthesis|down regulation of serotonin anabolism|negative regulation of serotonin synthesis|down-regulation of serotonin synthesis|down regulation of serotonin synthesis|negative regulation of serotonin formation|down-regulation of serotonin formation|downregulation of serotonin anabolism|inhibition of serotonin anabolism|down regulation of serotonin formation|downregulation of serotonin biosynthetic process|downregulation of serotonin biosynthesis|downregulation of serotonin synthesis|inhibition of serotonin synthesis|downregulation of serotonin formation|inhibition of serotonin formation|down regulation of serotonin biosynthetic process|down regulation of serotonin biosynthesis|negative regulation of serotonin anabolism|down-regulation of serotonin anabolism	http://purl.obolibrary.org/obo/GO_1905628		
GO:1905629	biolink:BiologicalProcess	positive regulation of serotonin biosynthetic process	Any process that activates or increases the frequency, rate or extent of serotonin biosynthetic process.		hp.json	upregulation of serotonin anabolism|positive regulation of serotonin synthesis|up regulation of serotonin formation|activation of serotonin formation|upregulation of serotonin biosynthesis|upregulation of serotonin biosynthetic process|positive regulation of serotonin formation|upregulation of serotonin synthesis|positive regulation of serotonin biosynthesis|upregulation of serotonin formation|up-regulation of serotonin anabolism|up regulation of serotonin biosynthetic process|up regulation of serotonin biosynthesis|up regulation of serotonin anabolism|up-regulation of serotonin biosynthetic process|activation of serotonin anabolism|up-regulation of serotonin biosynthesis|activation of serotonin biosynthesis|activation of serotonin biosynthetic process|up-regulation of serotonin synthesis|positive regulation of serotonin anabolism|up-regulation of serotonin formation|up regulation of serotonin synthesis|activation of serotonin synthesis	http://purl.obolibrary.org/obo/GO_1905629		
UBERON:0011927	biolink:AnatomicalEntity	preganglionic sympathetic fiber	A cholinergic axonal fiber projecting from the CNS to a sympathetic ganglion.	SCTID:323517007	hp.json	sympathetic preganglionic fiber	http://purl.obolibrary.org/obo/UBERON_0011927		
GO:0051450	biolink:BiologicalProcess	myoblast proliferation	The multiplication or reproduction of myoblasts, resulting in the expansion of a myoblast cell population. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.		hp.json		http://purl.obolibrary.org/obo/GO_0051450		
GO:0002407	biolink:BiologicalProcess	dendritic cell chemotaxis	The movement of a dendritic cell in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0002407		
GO:0002408	biolink:BiologicalProcess	myeloid dendritic cell chemotaxis	The movement of a myeloid dendritic cell in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0002408		
GO:0051451	biolink:BiologicalProcess	myoblast migration	The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.		hp.json		http://purl.obolibrary.org/obo/GO_0051451		
CHEBI:28358	biolink:ChemicalSubstance	rac-lactic acid	A racemate comprising equimolar amounts of (R)- and (S)-lactic acid.	CAS:50-21-5|CAS:50-21-5|DrugBank:DB04398|PMID:29079364|KEGG:C01432|PMID:17190852|KEGG:D00111|Beilstein:1209341|Reaxys:1209341|LIPID_MAPS_instance:LMFA01050002|Wikipedia:Lactic_acid|CAS:50-21-5	hp.json	alpha-hydroxypropanoic acid|(+-)-2-hydroxypropanoic acid|2-Hydroxypropionic acid|alpha-hydroxypropionic acid|E270|Milchsaeure|Lactic acid|rac-2-hydroxypropanoic acid|2-Hydroxypropanoic acid	http://purl.obolibrary.org/obo/CHEBI_28358		3_STAR
GO:0051469	biolink:BiologicalProcess	vesicle fusion with vacuole	The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole.		hp.json	heterotypic vacuole fusion (non-autophagic)|heterotypic vacuole fusion, non-autophagic	http://purl.obolibrary.org/obo/GO_0051469		
GO:2000690	biolink:BiologicalProcess	regulation of cardiac muscle cell myoblast differentiation	Any process that modulates the frequency, rate or extent of cardiac muscle cell myoblast differentiation.		hp.json	regulation of cardiac myoblast differentiation|regulation of myocardial precursor cell differentiation	http://purl.obolibrary.org/obo/GO_2000690		
GO:2000691	biolink:BiologicalProcess	negative regulation of cardiac muscle cell myoblast differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac muscle cell myoblast differentiation.		hp.json	negative regulation of myocardial precursor cell differentiation|negative regulation of cardiac myoblast differentiation	http://purl.obolibrary.org/obo/GO_2000691		
GO:1905632	biolink:BiologicalProcess	protein localization to euchromatin	A process in which a protein is transported to, or maintained in, a location within an euchromatin.		hp.json	protein localisation in euchromatin|protein localization in euchromatin|protein localisation to euchromatin	http://purl.obolibrary.org/obo/GO_1905632		
GO:1905633	biolink:BiologicalProcess	establishment of protein localization to euchromatin	The directed movement of a protein to a specific location in an euchromatin.		hp.json	establishment of protein localisation in euchromatin|establishment of protein localization in euchromatin|establishment of protein localisation to euchromatin	http://purl.obolibrary.org/obo/GO_1905633		
GO:1905634	biolink:BiologicalProcess	regulation of protein localization to chromatin	Any process that modulates the frequency, rate or extent of protein localization to chromatin.		hp.json	regulation of protein localisation to chromatin	http://purl.obolibrary.org/obo/GO_1905634		
UBERON:0011919	biolink:AnatomicalEntity	yolk sac blood island	Masses of developing blood cells attached to endothelium in the yolk sac.	EMAPA:16115|EHDAA2:0000177	hp.json	visceral yolk sac blood island|yolk sac blood islands	http://purl.obolibrary.org/obo/UBERON_0011919		pheno_slim
UBERON:0011918	biolink:AnatomicalEntity	line of Schwalbe	The thickened peripheral margin of the vitreous membrane of the cornea.	EMAPA:37895|FMA:58422	hp.json	Schwalbe's line|Schwalbe's ring|Schwalbe line	http://purl.obolibrary.org/obo/UBERON_0011918		pheno_slim
CHEBI:16385	biolink:ChemicalSubstance	organic sulfide	Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers.	KEGG:C00297	hp.json	organic sulfides|thioethers|sulfides|Sulfide|Thioether|RSR	http://purl.obolibrary.org/obo/CHEBI_16385		3_STAR
HP:0011131	biolink:PhenotypicFeature	Perianal dermatitis	The presence of a rash (change of color and texture) of the perianal skin.	UMLS:C0240705	hp.json	Perianal rash	http://purl.obolibrary.org/obo/HP_0011131		
HP:0011132	biolink:PhenotypicFeature	Chronic furunculosis	A furuncle (boil) is a skin infection involving an entire hair follicle and nearby skin tissue. Chronic furunculosis refers to recurrent episodes of furuncles, often caused by recurrent staphylococcus infection.	UMLS:C4023521	hp.json		http://purl.obolibrary.org/obo/HP_0011132		
HP:0011133	biolink:PhenotypicFeature	Increased sensitivity to ionizing radiation	An abnormally increased sensitivity to the effects of ionizing radiation.	UMLS:C4021850	hp.json	Increased sensitivity to ionising radiation	http://purl.obolibrary.org/obo/HP_0011133		
HP:0011134	biolink:PhenotypicFeature	Low-grade fever	Mild fever that does not exceed 38.5 degrees centigrade.	SNOMEDCT_US:304213008|UMLS:C0239574	hp.json	Mild fever|Low-grade fever	http://purl.obolibrary.org/obo/HP_0011134		
HP:0011135	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the sweat glands	Absence or developmental hypoplasia of the sweat glands.	UMLS:C4023520	hp.json	Absent/underdeveloped sweat glands|Absent/small sweat glands	http://purl.obolibrary.org/obo/HP_0011135		
HP:0011136	biolink:PhenotypicFeature	Aplasia of the sweat glands	Absence of the sweat glands.	UMLS:C2677485	hp.json	Absent sweat glands|Lack of sweat glands	http://purl.obolibrary.org/obo/HP_0011136		
HP:0011137	biolink:PhenotypicFeature	Non-pruritic urticaria	Pale reddish slightly elevated papules and plaques of 0.5-3 cm in diameter and not accompanied by pruritus.	UMLS:C4023519	hp.json	Non-itchy hives	http://purl.obolibrary.org/obo/HP_0011137		
HP:0011138	biolink:PhenotypicFeature	Abnormality of skin adnexa morphology	An abnormality of the skin adnexa (skin appendages), which are specialized skin structures located within the dermis and focally within the subcutaneous fatty tissue, comprising three histologically distinct structures: (1) the pilosebaceous unit (hair follicle and sebaceous glands); (2) the eccrine sweat glands; and (3) the apocrine glands.	UMLS:C4023518	hp.json	Abnormal skin appendage	http://purl.obolibrary.org/obo/HP_0011138		
HP:0011130	biolink:PhenotypicFeature	Abnormal renal calyx morphology	Any abnormality of the morphology of the major calices or minor calices of the kidney.	UMLS:C4023522	hp.json	Abnormality of renal calyx morphology	http://purl.obolibrary.org/obo/HP_0011130		
HP:0011139	biolink:PhenotypicFeature	Gastric duplication	Gastric duplication is a usually cystic malformation of gastrointestinal tract, usually attached to the greater curvature of the stomach and has no communication with the stomach.	UMLS:C4021201	hp.json	Gastric duplication cyst	http://purl.obolibrary.org/obo/HP_0011139		
HP:0011120	biolink:PhenotypicFeature	Concave nasal ridge	Nasal ridge curving posteriorly to an imaginary line that connects the nasal root and tip.	UMLS:C0264169|SNOMEDCT_US:710234009	hp.json	Saddle nose|Saddle nose deformity|Boxer's nose deformity|Boxer's nasal deformity|Ski jump nose|Concave dorsum of nose|Saddle shaped nasal dorsum|Concave nasal dorsum	http://purl.obolibrary.org/obo/HP_0011120		hposlim_core
HP:0011121	biolink:PhenotypicFeature	Abnormality of skin morphology	Any morphological abnormality of the skin.	Fyler:4133|UMLS:C4023528	hp.json	Abnormal skin structure|Abnormal skin morphology	http://purl.obolibrary.org/obo/HP_0011121		
HP:0011122	biolink:PhenotypicFeature	Abnormality of skin physiology	Any abnormality of the physiological function of the skin.	UMLS:C4023527	hp.json	Abnormality of skin physiology	http://purl.obolibrary.org/obo/HP_0011122		
HP:0011123	biolink:PhenotypicFeature	Inflammatory abnormality of the skin	The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes.	MP:0004947|UMLS:C0011603|SNOMEDCT_US:703938007|MSH:D003872|UMLS:C3875321	hp.json	Dermatitis|Inflammatory abnormality of the skin|Abnormal tendency to infections of the skin|Skin inflammation|Inflammatory skin disease	http://purl.obolibrary.org/obo/HP_0011123		
HP:0011124	biolink:PhenotypicFeature	Abnormal epidermal morphology	An abnormality of the morphology of the epidermis.	UMLS:C4023526	hp.json	Abnormality of epidermal morphology	http://purl.obolibrary.org/obo/HP_0011124		
HP:0011125	biolink:PhenotypicFeature	Abnormality of dermal melanosomes	An abnormality of the melanosomes, i.e., of the cellular organelles in which melanin pigments are synthesized and stored within melanocytes (the cells that produce pigment in the dermis).	UMLS:C4023525	hp.json		http://purl.obolibrary.org/obo/HP_0011125		
HP:0011126	biolink:PhenotypicFeature	Nephroptosis	A significant descent of the kidney as the patient moves from the supine to the erect position.	UMLS:C1384594	hp.json	Renal ptosis|Floating kidney	http://purl.obolibrary.org/obo/HP_0011126		
HP:0011127	biolink:PhenotypicFeature	Perioral eczema	A type of eczema that occurs in the lips and perioral area.	UMLS:C1396126	hp.json	Eczema around the mouth	http://purl.obolibrary.org/obo/HP_0011127		
HP:0011128	biolink:PhenotypicFeature	Acute esophageal necrosis	A condition characterized by necrosis of the mucosal and submucosal layers of the esophagus not related to ingestion of caustic or other injurious agents. Endoscopically, there is a dark lesion ('black esophagus') distributed in a circumferential manner in the distal one-third of the esophagus with or without exudates. There is involvement of the distal esophagus ending sharply at the gastroesophageal junction.	UMLS:C4023524	hp.json		http://purl.obolibrary.org/obo/HP_0011128		
ENVO:01001110	biolink:NamedThing	ecosystem			hp.json		http://purl.obolibrary.org/obo/ENVO_01001110		
HP:0011129	biolink:PhenotypicFeature	Bilateral fetal pyelectasis	A bilateral form of fetal pyelectasis.	UMLS:C4023523	hp.json	Bilateral foetal pyelectasis|Bilateral foetal pyelectasia|Bilateral fetal pyelectasia	http://purl.obolibrary.org/obo/HP_0011129		
HP:0011110	biolink:PhenotypicFeature	Recurrent tonsillitis	Inflammation of the tonsils that has occurred repeatedly. The definition of recurrent may vary somewhat, but the criteria used recently as a measure of severity were five or more episodes of true tonsillitis per year, symptoms recurring for at least a year, and episodes that are disabling and that prevent normal functioning. In some cases recurrent tonsillitis may be related to immunosusceptibility. Evidence exists for a genetic predisposition for recurrent tonsillitis.	UMLS:C0040425|MSH:D014069|SNOMEDCT_US:90176007	hp.json	Recurrent inflammation of tonsils	http://purl.obolibrary.org/obo/HP_0011110		
HP:0011111	biolink:PhenotypicFeature	Abnormality of immune serum protein physiology	An abnormality of the concentration or function of circulating immune proteins.	UMLS:C4023536	hp.json		http://purl.obolibrary.org/obo/HP_0011111		
HP:0011112	biolink:PhenotypicFeature	Abnormality of serum cytokine level	Abnormality of the cytokine levels in the blood, i.e., an abnormality of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells.	UMLS:C4023535|MP:0010210	hp.json		http://purl.obolibrary.org/obo/HP_0011112		
HP:0011113	biolink:PhenotypicFeature	Abnormality of cytokine secretion	An abnormality in the production or cellular release of a cytokine (i.e., any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells).	UMLS:C4023534|MP:0003009	hp.json		http://purl.obolibrary.org/obo/HP_0011113		
HP:0011114	biolink:PhenotypicFeature	Defective production of NFKB1-dependent cytokines	An impairment in the production by leukocytes of NFKB1-dependent cytokines such as tumor necrosis factor-alpha and interferon-alpha.	UMLS:C4023533	hp.json		http://purl.obolibrary.org/obo/HP_0011114		
HP:0011115	biolink:PhenotypicFeature	Abnormality of chemokine secretion	An abnormality in the production or cellular release of a chemokine (a class of cytokines).	UMLS:C4023532	hp.json		http://purl.obolibrary.org/obo/HP_0011115		
HP:0011116	biolink:PhenotypicFeature	Abnormality of interferon secretion	An abnormality in the production or cellular release of interferons (a class of cytokines).	UMLS:C4023531	hp.json		http://purl.obolibrary.org/obo/HP_0011116		
HP:0001789	biolink:PhenotypicFeature	Hydrops fetalis	The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema.	MSH:D015160|UMLS:C0020305|SNOMEDCT_US:276508000	hp.json		http://purl.obolibrary.org/obo/HP_0001789		
HP:0001783	biolink:PhenotypicFeature	Broad metatarsal	Increased side-to-side width of a metatarsal bone.	UMLS:C1842231|UMLS:C1850161	hp.json	Broad metatarsals|Wide long bone of foot|Widened metatarsal shaft	http://purl.obolibrary.org/obo/HP_0001783		
HP:0410401	biolink:PhenotypicFeature	Worse in evening	Applies to a sign or symptom that is exacerbated in the evening as compared to the day.		hp.json		http://purl.obolibrary.org/obo/HP_0410401		
HP:0410400	biolink:PhenotypicFeature	Absent sebaceous glands	Absence of the sebaceous gland, the holocrine gland that secretes sebum into the hair follicles, or in hairless areas into ducts.		hp.json	Absence of sebaceous glands	http://purl.obolibrary.org/obo/HP_0410400		
HP:0001782	biolink:PhenotypicFeature	Bulbous tips of toes	An abnormality of the morphology of the toes, such that the tips of the toes are prominent and bulbous.	UMLS:C4025747	hp.json		http://purl.obolibrary.org/obo/HP_0001782		
HP:0001787	biolink:PhenotypicFeature	Abnormal delivery	An abnormality of the birth process.	SNOMEDCT_US:274127000|UMLS:C0549629	hp.json	Abnormal delivery|Delivery complication	http://purl.obolibrary.org/obo/HP_0001787		
HP:0001788	biolink:PhenotypicFeature	Premature rupture of membranes	Premature rupture of membranes (PROM) is a condition which occurs in pregnancy when the amniotic sac ruptures more than an hour before the onset of labor.	SNOMEDCT_US:237266003|UMLS:C0015944|MSH:D005322|SNOMEDCT_US:44223004	hp.json		http://purl.obolibrary.org/obo/HP_0001788		
HP:0001785	biolink:PhenotypicFeature	Ankle swelling		SNOMEDCT_US:26237000|UMLS:C0235439|SNOMEDCT_US:267039000	hp.json	Ankle swelling	http://purl.obolibrary.org/obo/HP_0001785		
HP:0001786	biolink:PhenotypicFeature	Narrow foot	A foot for which the measured width is below the 5th centile for age; or, a foot that appears disproportionately narrow for its length.	SNOMEDCT_US:299464006|UMLS:C0576227	hp.json	Slender feet|Narrow foot	http://purl.obolibrary.org/obo/HP_0001786		hposlim_core
HP:0011117	biolink:PhenotypicFeature	Abnormality of interleukin secretion	An abnormality in the production or cellular release of interleukins (a class of cytokines).	UMLS:C4023530	hp.json	Abnormality of IL secretion	http://purl.obolibrary.org/obo/HP_0011117		
HP:0011118	biolink:PhenotypicFeature	Abnormality of tumor necrosis factor secretion	An abnormality in the production or cellular release of tumor necrosis factor.	UMLS:C4023529|MP:0008556	hp.json	Abnormality of cachexin secretion|Abnormality of cachectin secretion|Abnormality of tumour necrosis factor secretion	http://purl.obolibrary.org/obo/HP_0011118		
HP:0011119	biolink:PhenotypicFeature	Abnormality of the nasal dorsum	An abnormality of the nasal dorsum, also known as the nasal ridge.	UMLS:C4280332|UMLS:C4021202	hp.json	Deformity of the nasal dorsum|Abnormality of the dorsum of nose|Malformation of the nasal dorsum|Malformation of the nasal ridge|Crooked dorsum of nose|Deformity of the nasal ridge|Abnormality of the nasal ridge|Abnormal morphology of dorsum of nose|Deformity of the dorsum of the nose|Crooked nasal ridge|Malformation of the dorsum of nose|Crooked nasal dorsum|Anomaly of the nasal ridge	http://purl.obolibrary.org/obo/HP_0011119		
HP:0001780	biolink:PhenotypicFeature	Abnormality of toe	An anomaly of a toe.	UMLS:C2674738	hp.json	Abnormality of toe|Abnormalities of the toes	http://purl.obolibrary.org/obo/HP_0001780		hposlim_core
HP:0011100	biolink:PhenotypicFeature	Intestinal atresia	An abnormal closure, or atresia of the tubular structure of the intestine.	MSH:D007409|UMLS:C0021828	hp.json		http://purl.obolibrary.org/obo/HP_0011100		
HP:0011102	biolink:PhenotypicFeature	Ileal atresia	An abnormal closure, or atresia of the tubular structure of the ileum.	UMLS:C0266176|SNOMEDCT_US:25896009	hp.json		http://purl.obolibrary.org/obo/HP_0011102		
HP:0011103	biolink:PhenotypicFeature	Abnormal left ventricular outflow tract morphology	An abnormality of the outflow tract of the left ventricle.	SNOMEDCT_US:253545000|UMLS:C0344916	hp.json	Abnormality of the left ventricular outflow tract	http://purl.obolibrary.org/obo/HP_0011103		
HP:0011104	biolink:PhenotypicFeature	Abnormality of blood volume homeostasis	An abnormality in the amount of volume occupied by intravascular blood.	UMLS:C4023537	hp.json		http://purl.obolibrary.org/obo/HP_0011104		
HP:0011105	biolink:PhenotypicFeature	Hypervolemia	An increase in the amount of intravascular fluid, particularly in the volume of the circulating blood.	SNOMEDCT_US:21639008|UMLS:C0546817	hp.json	Fluid overload in blood	http://purl.obolibrary.org/obo/HP_0011105		
HP:0001795	biolink:PhenotypicFeature	Hyperconvex nail	When viewed on end (with the digit tip pointing toward the examiner's eye) the curve of the nail forms a tighter curve of convexity.	UMLS:C0423807|SNOMEDCT_US:247487009	hp.json	Increased nail curvature|Nail overcurvature	http://purl.obolibrary.org/obo/HP_0001795		hposlim_core
HP:0001792	biolink:PhenotypicFeature	Small nail	A nail that is diminished in length and width, i.e., underdeveloped nail.	UMLS:C0263523|SNOMEDCT_US:11375002	hp.json	Nail hypoplasia|Hypoplastic nails|Small nails|Hypoplastic nail|Small nail	http://purl.obolibrary.org/obo/HP_0001792		
HP:0001798	biolink:PhenotypicFeature	Anonychia	Aplasia of the nail.	UMLS:C0265998|MSH:C536377|SNOMEDCT_US:23610003	hp.json	Aplastic nails|Absent nails	http://purl.obolibrary.org/obo/HP_0001798		hposlim_core
HP:0001799	biolink:PhenotypicFeature	Short nail	Decreased length of nail.	UMLS:C0423808|SNOMEDCT_US:247488004	hp.json	Short nail|Short nails	http://purl.obolibrary.org/obo/HP_0001799		hposlim_core
HP:0011106	biolink:PhenotypicFeature	Hypovolemia	An decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood.	UMLS:C0546884|MSH:D020896|SNOMEDCT_US:28560003	hp.json	Depleted blood volume	http://purl.obolibrary.org/obo/HP_0011106		
HP:0011107	biolink:PhenotypicFeature	Recurrent aphthous stomatitis	Recurrent episodes of ulceration of the oral mucosa, typically presenting as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border.	SNOMEDCT_US:110426005|SNOMEDCT_US:427617000|MSH:D013281|UMLS:C0038363|SNOMEDCT_US:426965005|UMLS:C2937365|SNOMEDCT_US:398870000	hp.json	Recurrent oral aphthae|Buccal aphthous ulcers|Aphthous stomatitis|Recurrent canker sores|Recurrent aphthous ulcers	http://purl.obolibrary.org/obo/HP_0011107		
HP:0011108	biolink:PhenotypicFeature	Recurrent sinusitis	A recurrent form of sinusitis.	UMLS:C4280333|SNOMEDCT_US:195788001|UMLS:C0581354	hp.json	Recurrent sinus disease|Sinusitis, recurrent	http://purl.obolibrary.org/obo/HP_0011108		
HP:0011109	biolink:PhenotypicFeature	Chronic sinusitis	A chronic form of sinusitis.	SNOMEDCT_US:40055000|UMLS:C0748720|UMLS:C0149516	hp.json	Chronic sinus disease|Sinusitis, chronic	http://purl.obolibrary.org/obo/HP_0011109		
HP:0001790	biolink:PhenotypicFeature	Nonimmune hydrops fetalis	A type of hydrops fetalis in which there is no identifiable circulating antibody to red blood cell antigens .	UMLS:C0455988|SNOMEDCT_US:206538000|SNOMEDCT_US:276509008|MSH:D015160	hp.json	Hydrops fetalis, nonimmune|Non-immune fetal hydrops|Hydrops fetalis, non-immune|Nonimmune hydrops|Non-immune foetal hydrops	http://purl.obolibrary.org/obo/HP_0001790		
HP:0001791	biolink:PhenotypicFeature	Fetal ascites	Accumulation of fluid in the peritoneal cavity during the fetal period.	SNOMEDCT_US:363125002|UMLS:C1285291	hp.json	Foetal ascites	http://purl.obolibrary.org/obo/HP_0001791		
HP:0011175	biolink:PhenotypicFeature	Focal motor seizure with version	A type of focal motor seizure characterised by sustained, forced conjugate ocular, cephalic, and/or truncal rotation or lateral deviation from the midline as the initial semiological manifestation.	SNOMEDCT_US:246530009|UMLS:C0422846|MSH:D020938	hp.json	Versive seizures|Versive seizure	http://purl.obolibrary.org/obo/HP_0011175		
HP:0011176	biolink:PhenotypicFeature	EEG with constitutional variants	An EEG with constitutional variants contains waves that are rare or unusual but not generally pathologic.	UMLS:C4023496	hp.json		http://purl.obolibrary.org/obo/HP_0011176		
HP:0011177	biolink:PhenotypicFeature	EEG with 4-5/second background activity	EEG background activity at 4-5/second.	UMLS:C4023495	hp.json		http://purl.obolibrary.org/obo/HP_0011177		
HP:0011178	biolink:PhenotypicFeature	Alpha-EEG	EEG dominated by diffuse alpha-waves (8-13Hz).	UMLS:C4023494	hp.json		http://purl.obolibrary.org/obo/HP_0011178		
HP:0011179	biolink:PhenotypicFeature	Beta-EEG	EEG dominated by diffuse beta-waves (>13 Hz).	UMLS:C4023493	hp.json	Beta wave electroencephalography	http://purl.obolibrary.org/obo/HP_0011179		
HP:0011170	biolink:PhenotypicFeature	Generalized myoclonic-atonic seizure	A generalized myoclonic-atonic seizure is a type of generalized motor seizure characterized by a myoclonic jerk followed by an atonic motor component.	UMLS:C0393702|SNOMEDCT_US:230421008|MSH:D004831	hp.json	Generalised myoclonic-atonic seizure|Myoclonic-astatic seizure|Myoclonic atonic seizures	http://purl.obolibrary.org/obo/HP_0011170		
HP:0011171	biolink:PhenotypicFeature	Simple febrile seizure	A short generalized seizure, of a duration of <15 min, not recurring within 24 h, occurring during a febrile episode not caused by an acute disease of the nervous system intracranial infection or severe metabolic disturbance.	UMLS:C0149886|MSH:D003294|SNOMEDCT_US:432354000	hp.json	Simple fever fit|Simple febrile convulsion|Simple febrile seizures	http://purl.obolibrary.org/obo/HP_0011171		
HP:0011172	biolink:PhenotypicFeature	Complex febrile seizure	A febrile seizure that has any of the following features: focal semiology (or associated with post-ictal neurologic abnormalities beyond drowsiness, such as a Todd's paresis), prolonged seizure beyond 15 minutes, or recurring (occurring more than once) in a 24 hour period.	UMLS:C0751057|MSH:D003294|SNOMEDCT_US:433083002	hp.json	Complex fever fit|Complex febrile seizures|Complex febrile convulsion	http://purl.obolibrary.org/obo/HP_0011172		
HP:0011173	biolink:PhenotypicFeature	Focal behavior arrest seizure	A type of focal non-motor seizure characterized by an arrest or pause of activities, freezing, or immobilization as the predominant semiological feature throughout the seizure.	UMLS:C4023498	hp.json	Focal behaviour arrest seizure|Partial seizure with behaviour arrest|Hypokinetic seizures|Partial seizure with behavior arrest|Focal hypokinetic seizure|Localised seizure with behavioural arrest|Partial hypokinetic seizure|Hypokinetic seizure|Localized seizure with behavioral arrest	http://purl.obolibrary.org/obo/HP_0011173		
HP:0011174	biolink:PhenotypicFeature	Focal hyperkinetic seizure	A focal seizure characterized at onset by predominantly proximal limb or axial muscles producing irregular sequential ballistic movements, such as pedaling, pelvic thrusting, thrashing, rocking movements.	UMLS:C4023497	hp.json	Localized hyperkinetic seizure|Hyperkinetic seizures|Segmental hyperkinetic seizure|Partial hyperkinetic seizure|Localised hyperkinetic seizure	http://purl.obolibrary.org/obo/HP_0011174		
HP:0011164	biolink:PhenotypicFeature	obsolete Vegetative auras			hp.json		http://purl.obolibrary.org/obo/HP_0011164		
HP:0011165	biolink:PhenotypicFeature	Focal sensory seizure with visual features	A seizure characterized by elementary visual hallucinations such as flashing or flickering lights/colours, or other shapes, simple patterns, scotomata, or amaurosis as its first clinical manifestation.	UMLS:C1850765	hp.json	Simple partial occipital seizures|Partial visual seizure|Visual aura|Visual auras|Focal visual seizure	http://purl.obolibrary.org/obo/HP_0011165		
HP:0011166	biolink:PhenotypicFeature	Focal myoclonic seizure	A type of focal motor seizure characterized by sudden, brief (<100 ms) involuntary single or multiple contraction(s) of muscles(s) or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus.	UMLS:C4023501	hp.json	Localised myoclonic seizure|Partial myoclonic seizure|Focal myoclonic seizures|Segmental myoclonic seizure|Localized myoclonic seizure|Local myoclonic seizures|Partial myoclonic seizures|Segmental myoclonic seizures	http://purl.obolibrary.org/obo/HP_0011166		
HP:0011167	biolink:PhenotypicFeature	Focal tonic seizure	A type of focal motor seizure characterized by sustained increase in muscle contraction, lasting a few seconds to minutes.	MSH:D020938|UMLS:C0752324	hp.json	Localized tonic seizure|Local tonic seizures|Localised tonic seizure|Partial tonic seizures|Partial tonic seizure|Segmental tonic seizure|Focal tonic seizures	http://purl.obolibrary.org/obo/HP_0011167		
HP:0011168	biolink:PhenotypicFeature	Focal seizure with eyelid myoclonia	Focal seizure with eyelid myoclonia, not eyelid myoclonias in the context of absence seizures.	UMLS:C4023500	hp.json	Eyelid myoclonias	http://purl.obolibrary.org/obo/HP_0011168		
HP:0011169	biolink:PhenotypicFeature	Generalized clonic seizure	Generalized clonic seizure is a type of generalized motor seizure characterised by sustained bilateral jerking, either symmetric or asymmetric, that is regularly repetitive and involves the same muscle groups.	UMLS:C4023499	hp.json	Generalised clonic seizures|Generalized onset clonic seizure|Generalized-onset clonic seizure|Generalized clonic seizures|Generalised clonic seizure|Generalised onset clonic seizure|Generalised-onset clonic seizure	http://purl.obolibrary.org/obo/HP_0011169		
HP:0011160	biolink:PhenotypicFeature	Focal sensory seizure with gustatory features	A seizure characterized by taste phenomena including acidic, bitter, salty, sweet, or metallic tastes as its first clinical manifestation.	MSH:D006212|UMLS:C0233766|SNOMEDCT_US:29139005	hp.json	Partial gustatory seizure|Gustatory auras|Taste hallucinations|Gustatory aura|Focal gustatory seizure|Focal sensory gustatory seizure	http://purl.obolibrary.org/obo/HP_0011160		
HP:0011161	biolink:PhenotypicFeature	Focal sensory seizure with olfactory features	Seizures characterized by olfactory phenomena as its first clinical manifestation.	UMLS:C4023504	hp.json	Focal olfactory seizure|Olfactory aura|Partial olfactory seizure|Olfactory auras	http://purl.obolibrary.org/obo/HP_0011161		
HP:0011162	biolink:PhenotypicFeature	obsolete Psychic auras			hp.json		http://purl.obolibrary.org/obo/HP_0011162		
HP:0011163	biolink:PhenotypicFeature	Focal sensory seizure with somatosensory features	A seizure characterized by sensory phenomena including tingling, numbness, electric-shock like sensation, pain, sense of movement, or desire to move as its first clinical manifestation.	UMLS:C4023502	hp.json	Partial somatosensory seizure|Somatosensory auras|Somatosensory aura|Focal somatosensory seizure	http://purl.obolibrary.org/obo/HP_0011163		
PR:000003777	biolink:Protein	adiponectin	A protein that is a translation product of the human ADIPOQ gene or a 1:1 ortholog thereof.		hp.json	ACRP30|apM-1|gelatin-binding protein|GBP28|adipocyte complement-related 30 kDa protein|ADIPOQ|adipocyte, C1q and collagen domain-containing protein|APM1|ACDC|adipocyte-specific protein AdipoQ|30 kDa adipocyte complement-related protein|adipose most abundant gene transcript 1 protein	http://purl.obolibrary.org/obo/PR_000003777		
HP:0011153	biolink:PhenotypicFeature	Focal motor seizure	A type of focal-onset seizure characterized by a motor sign as its initial semiological manifestation.	MSH:D020938|SNOMEDCT_US:82401000|UMLS:C0016399|SNOMEDCT_US:128612007	hp.json	Localised motor seizure|Partial motor seizures|Partial motor seizure|Segmental motor seizure|Focal motor seizures|Localized motor seizures|Localized motor seizure|Localised motor seizures	http://purl.obolibrary.org/obo/HP_0011153		
HP:0011154	biolink:PhenotypicFeature	Focal autonomic seizure	An autonomic seizure is a type of focal non-motor seizure characterized by alteration of autonomic nervous system function as the initial semiological feature.	UMLS:C4023509	hp.json	Focal autonomic seizures	http://purl.obolibrary.org/obo/HP_0011154		
HP:0011155	biolink:PhenotypicFeature	obsolete Focal autonomic seizures with altered responsiveness			hp.json		http://purl.obolibrary.org/obo/HP_0011155		
HP:0011156	biolink:PhenotypicFeature	obsolete Focal autonomic seizures without altered responsiveness			hp.json		http://purl.obolibrary.org/obo/HP_0011156		
HP:0011157	biolink:PhenotypicFeature	Focal sensory seizure	A focal sensory seizure is a type seizure beginning with a subjective sensation.	UMLS:C0236018|SNOMEDCT_US:18618006|MSH:D004827	hp.json	Focal sensory seizures|Partial sensory seizure|Sensory aura	http://purl.obolibrary.org/obo/HP_0011157		
HP:0011158	biolink:PhenotypicFeature	Focal sensory seizure with auditory features	A seizure characterized by elementary auditory phenomena including buzzing, ringing, drumming or single tones as its first clinical manifestation.	UMLS:C1838063	hp.json	Partial auditory seizure|Focal sensory auditory seizure|Focal auditory seizure|Auditory aura	http://purl.obolibrary.org/obo/HP_0011158		
HP:0011159	biolink:PhenotypicFeature	Focal autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena	A type of focal autonomic seizure characterised by symptoms or signs pertaining to the gastrointestinal system as the initial semiological feature.	UMLS:C4023506	hp.json	Partial seizure with epigastric sensation|Epigastric aura|Abdominal aura|Localized seizure with epigastric sensation|Epigastric auras|Localised seizure with epigastric sensation|Visceral aura	http://purl.obolibrary.org/obo/HP_0011159		
HP:0011150	biolink:PhenotypicFeature	Myoclonic absence seizure	Myoclonic absence seizure is a type of generalized non-motor (absence) seizure characterised by an interruption of ongoing activities, a blank stare and rhythmic three-per-second myoclonic movements, causing ratcheting abduction of the upper limbs leading to progressive arm elevation, and associated with 3 Hz generalized spike-wave discharges on the electroencephalogram. Duration is typically 10-60 s. Whilst impairment of consciousness may not be obvious the ILAE classified this seizure as a generalized non-motor seizure in 2017.	UMLS:C4023512	hp.json	Myoclonic absences|Myoclonic absence	http://purl.obolibrary.org/obo/HP_0011150		
HP:0011151	biolink:PhenotypicFeature	Atypical absence status epilepticus	Atypical absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged atypical absence seizure.	UMLS:C4023511	hp.json	Obtundation status	http://purl.obolibrary.org/obo/HP_0011151		
HP:0011152	biolink:PhenotypicFeature	Early onset absence seizures	Typical absence seizures starting before the age of 4 years.	UMLS:C4023510	hp.json	Early onset petit mal seizures	http://purl.obolibrary.org/obo/HP_0011152		
HP:0011142	biolink:PhenotypicFeature	Age-related nuclear cataract	A type of age-related cataract that primarily affects the nucleus of the lens.	MSH:C563333|UMLS:C1832423	hp.json		http://purl.obolibrary.org/obo/HP_0011142		
HP:0011143	biolink:PhenotypicFeature	Age-related cortical cataract	A type of age-related cataract that primarily affects the cortex of the lens.	UMLS:C2880562	hp.json		http://purl.obolibrary.org/obo/HP_0011143		
HP:0011144	biolink:PhenotypicFeature	Age-related posterior subcapsular cataract	A type of age-related cataract consisting of granular opacities occurring mainly in the central posterior cortex just under the posterior capsule.	UMLS:C4023517	hp.json		http://purl.obolibrary.org/obo/HP_0011144		
HP:0011145	biolink:PhenotypicFeature	Symptomatic seizures	A seizure that occurs in the context of a brain insult (systemic, toxic, or metabolic) and may not recur when the underlying cause has been removed or the acute phase has elapsed.	UMLS:C4023516	hp.json		http://purl.obolibrary.org/obo/HP_0011145		
HP:0011146	biolink:PhenotypicFeature	Dialeptic seizure	A dialeptic seizure is a type of seizure characterised predominantly by reduced responsiveness or awareness and with subsequent at least partial amnesia of the event.		hp.json	Unknown onset behavioural arrest seizure with impairment of awareness|Unknown onset behavioral arrest seizure with impairment of awareness|Behavioral arrest seizure with impairment of awareness irrespective of onset|Behavioural arrest seizure with impairment of awareness irrespective of onset	http://purl.obolibrary.org/obo/HP_0011146		
HP:0011147	biolink:PhenotypicFeature	Typical absence seizure	A typical absence seizure is a type of generalised non-motor (absence) seizure characterised by its sudden onset, interruption of ongoing activities, a blank stare, possibly a brief upward deviation of the eyes. Usually the patient will be unresponsive when spoken to. Duration is a few seconds to half a minute with very rapid recovery. Although not always available, an EEG would usually show 3 Hz generalized epileptiform discharges during the event.	MSH:D004832|SNOMEDCT_US:432241000124101|SNOMEDCT_US:79631006|SNOMEDCT_US:50866000|UMLS:C0014553|SNOMEDCT_US:230413002	hp.json	Typical absence|Typical absence seizures	http://purl.obolibrary.org/obo/HP_0011147		
HP:0011148	biolink:PhenotypicFeature	obsolete Absence seizures with special features			hp.json		http://purl.obolibrary.org/obo/HP_0011148		
HP:0011149	biolink:PhenotypicFeature	Absence seizure with eyelid myoclonia	An absence with eyelid myoclonia seizure is a type of generalized non-motor (absence) seizure characterised by forced upward jerking of the eyelids during an absence seizure.	UMLS:C4023513	hp.json	Absence seizures with eyelid myoclonia	http://purl.obolibrary.org/obo/HP_0011149		
HP:0011140	biolink:PhenotypicFeature	Gastrointestinal duplication	A spherical hollow structure with a smooth muscle coat, lined by a mucous membrane, and attached to any part of the gastrointestinal tract, from the base of the tongue to the anus.	UMLS:C0266019|SNOMEDCT_US:33257003	hp.json	GI duplication	http://purl.obolibrary.org/obo/HP_0011140		
HP:0011141	biolink:PhenotypicFeature	Age-related cataract	A type of cataract (opacification of the lens) that forms during the course of aging.	UMLS:C0036646|SNOMEDCT_US:39450006	hp.json	Clouding of the lens of the eye with age	http://purl.obolibrary.org/obo/HP_0011141		
GO:0031109	biolink:BiologicalProcess	microtubule polymerization or depolymerization	Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.		hp.json		http://purl.obolibrary.org/obo/GO_0031109		
GO:0021782	biolink:BiologicalProcess	glial cell development	The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0021782		
GO:0021783	biolink:BiologicalProcess	preganglionic parasympathetic fiber development	The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion.		hp.json		http://purl.obolibrary.org/obo/GO_0021783		
GO:0006144	biolink:BiologicalProcess	purine nucleobase metabolic process	The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.		hp.json	purine base metabolic process|purine metabolic process|purine base metabolism|purine metabolism	http://purl.obolibrary.org/obo/GO_0006144		
GO:0006142	biolink:BiologicalProcess	regulation of pyrimidine nucleobase metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.		hp.json	regulation of pyrimidine base metabolic process|regulation of pyrimidine base metabolism	http://purl.obolibrary.org/obo/GO_0006142		
GO:0006140	biolink:BiologicalProcess	regulation of nucleotide metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.		hp.json	regulation of nucleotide metabolism	http://purl.obolibrary.org/obo/GO_0006140		
GO:0006141	biolink:BiologicalProcess	regulation of purine nucleobase metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines.		hp.json	regulation of purine base metabolism|regulation of purine base metabolic process	http://purl.obolibrary.org/obo/GO_0006141		
GO:0045759	biolink:BiologicalProcess	negative regulation of action potential	Any process that stops, prevents, or reduces the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.		hp.json	down regulation of action potential|inhibition of action potential|down-regulation of action potential|downregulation of action potential	http://purl.obolibrary.org/obo/GO_0045759		
UBERON:7500049	biolink:AnatomicalEntity	proximal-most point of greater trochanter of femur	The proximal-most point of the greater trochanter of a femur.		hp.json		http://purl.obolibrary.org/obo/UBERON_7500049		
GO:0033762	biolink:BiologicalProcess	response to glucagon	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.		hp.json	response to glucagon stimulus	http://purl.obolibrary.org/obo/GO_0033762		
UBERON:7500040	biolink:AnatomicalEntity	tip of nail	The distal-most point of a cutaneous appendage.		hp.json		http://purl.obolibrary.org/obo/UBERON_7500040		
UBERON:7500046	biolink:AnatomicalEntity	proximal-most point of head of femur	The proximal-most point of the head of a femur.		hp.json		http://purl.obolibrary.org/obo/UBERON_7500046		
UBERON:7500047	biolink:AnatomicalEntity	proximal-most point of head of humerus	The proximal-most point of the head of a humerus.		hp.json		http://purl.obolibrary.org/obo/UBERON_7500047		
GO:0045765	biolink:BiologicalProcess	regulation of angiogenesis	Any process that modulates the frequency, rate or extent of angiogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_0045765		
GO:0045766	biolink:BiologicalProcess	positive regulation of angiogenesis	Any process that activates or increases angiogenesis.		hp.json	stimulation of angiogenesis|up regulation of angiogenesis|activation of angiogenesis|up-regulation of angiogenesis|upregulation of angiogenesis	http://purl.obolibrary.org/obo/GO_0045766		
GO:0045763	biolink:BiologicalProcess	negative regulation of cellular amino acid metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amino acid.		hp.json	inhibition of amino acid metabolic process|down-regulation of amino acid metabolic process|negative regulation of amino acid metabolism|downregulation of amino acid metabolic process|down regulation of amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0045763		
GO:0045764	biolink:BiologicalProcess	positive regulation of cellular amino acid metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amino acid.		hp.json	upregulation of amino acid metabolic process|positive regulation of amino acid metabolism|up regulation of amino acid metabolic process|stimulation of amino acid metabolic process|activation of amino acid metabolic process|up-regulation of amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0045764		
GO:0045760	biolink:BiologicalProcess	positive regulation of action potential	Any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.		hp.json	up regulation of action potential|stimulation of action potential|up-regulation of action potential|activation of action potential|upregulation of action potential	http://purl.obolibrary.org/obo/GO_0045760		
PR:000007499	biolink:Protein	fibroblast growth factor 8	A protein that is a translation product of the human FGF8 gene or a 1:1 ortholog thereof.		hp.json	heparin-binding growth factor 8|FGF8|androgen-induced growth factor|FGF-8|HBGF-8|AIGF	http://purl.obolibrary.org/obo/PR_000007499		
GO:0045769	biolink:BiologicalProcess	negative regulation of asymmetric cell division	Any process that stops, prevents, or reduces the frequency, rate or extent of asymmetric cell division.		hp.json	down regulation of asymmetric cell division|inhibition of asymmetric cell division|down-regulation of asymmetric cell division|downregulation of asymmetric cell division	http://purl.obolibrary.org/obo/GO_0045769		
GO:0033750	biolink:BiologicalProcess	ribosome localization	A process in which a ribosome is transported to, and/or maintained in, a specific location.		hp.json	ribosome localisation|establishment of ribosome localisation|establishment of ribosome localization	http://purl.obolibrary.org/obo/GO_0033750		
GO:0018130	biolink:BiologicalProcess	heterocycle biosynthetic process	The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).		hp.json	heterocycle anabolism|heterocycle biosynthesis|heterocycle synthesis|heterocycle formation	http://purl.obolibrary.org/obo/GO_0018130		
UBERON:7500073	biolink:AnatomicalEntity	left nasal bone	Nasal bone on the left side of an organism when in anatomical position.		hp.json		http://purl.obolibrary.org/obo/UBERON_7500073		
UBERON:7500074	biolink:AnatomicalEntity	right nasal bone	Nasal bone on the right side of an organism when in anatomical position.		hp.json		http://purl.obolibrary.org/obo/UBERON_7500074		
UBERON:7500075	biolink:AnatomicalEntity	left zygomatic arch	Zygomatic arch on the left side of an organism when in anatomical position.		hp.json		http://purl.obolibrary.org/obo/UBERON_7500075		
UBERON:7500076	biolink:AnatomicalEntity	right zygomatic arch	Zygomatic arch on the right side of an organism when in anatomical position.		hp.json		http://purl.obolibrary.org/obo/UBERON_7500076		
UBERON:7500078	biolink:AnatomicalEntity	styloid process of radius	A condyle on the distal end and lateral side of a radius.		hp.json	radial styloid process|radial condyle	http://purl.obolibrary.org/obo/UBERON_7500078		
GO:0045770	biolink:BiologicalProcess	positive regulation of asymmetric cell division	Any process that activates or increases the frequency, rate or extent of asymmetric cell division.		hp.json	up regulation of asymmetric cell division|stimulation of asymmetric cell division|up-regulation of asymmetric cell division|activation of asymmetric cell division|upregulation of asymmetric cell division	http://purl.obolibrary.org/obo/GO_0045770		
GO:0045778	biolink:BiologicalProcess	positive regulation of ossification	Any process that activates or increases the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.		hp.json	positive regulation of bone formation|positive regulation of bone biosynthesis|upregulation of ossification|stimulation of ossification|up regulation of ossification|activation of ossification|up-regulation of ossification	http://purl.obolibrary.org/obo/GO_0045778		
GO:0045779	biolink:BiologicalProcess	negative regulation of bone resorption	Any process that stops, prevents, or reduces the frequency, rate or extent of bone resorption.		hp.json	down-regulation of bone resorption|down regulation of bone resorption|downregulation of bone resorption|inhibition of bone resorption	http://purl.obolibrary.org/obo/GO_0045779		
UBERON:7500062	biolink:AnatomicalEntity	tibial tuberosity	The tibial tuberosity is on the anterior side of a tibia and is where a patella ligament attaches.		hp.json	fossa digitalis	http://purl.obolibrary.org/obo/UBERON_7500062		
GO:0045780	biolink:BiologicalProcess	positive regulation of bone resorption	Any process that activates or increases the frequency, rate or extent of bone resorption.		hp.json	up-regulation of bone resorption|up regulation of bone resorption|activation of bone resorption|stimulation of bone resorption|upregulation of bone resorption	http://purl.obolibrary.org/obo/GO_0045780		
UBERON:7500065	biolink:AnatomicalEntity	condyle of talus	An articular prominence of a talus that engages with the tibia.		hp.json	condyle of astragalus	http://purl.obolibrary.org/obo/UBERON_7500065		
GO:0006139	biolink:BiologicalProcess	nucleobase-containing compound metabolic process	Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.		hp.json	cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|nucleobase, nucleoside and nucleotide metabolic process|nucleobase, nucleoside, nucleotide and nucleic acid metabolism|cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	http://purl.obolibrary.org/obo/GO_0006139		goslim_plant|goslim_pir
GO:0021751	biolink:BiologicalProcess	salivary nucleus development	The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0021751		
GO:0055107	biolink:BiologicalProcess	Golgi to secretory granule transport	The directed movement of proteins from the Golgi to a secretory granule. The secretory granule is a membrane-bounded particle, usually protein, formed in the granular endoplasmic reticulum and the Golgi complex.		hp.json		http://purl.obolibrary.org/obo/GO_0055107		
GO:0055108	biolink:BiologicalProcess	Golgi to transport vesicle transport	The directed movement of proteins from the Golgi to a transport vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis.		hp.json		http://purl.obolibrary.org/obo/GO_0055108		
GO:0021753	biolink:BiologicalProcess	superior salivary nucleus development	The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0021753		
GO:0045787	biolink:BiologicalProcess	positive regulation of cell cycle	Any process that activates or increases the rate or extent of progression through the cell cycle.		hp.json	stimulation of progression through cell cycle|up-regulation of progression through cell cycle|positive regulation of progression through cell cycle|positive regulation of cell cycle progression|activation of progression through cell cycle|upregulation of progression through cell cycle|up regulation of progression through cell cycle	http://purl.obolibrary.org/obo/GO_0045787		
GO:0045785	biolink:BiologicalProcess	positive regulation of cell adhesion	Any process that activates or increases the frequency, rate or extent of cell adhesion.		hp.json	up-regulation of cell adhesion|up regulation of cell adhesion|activation of cell adhesion|stimulation of cell adhesion|upregulation of cell adhesion	http://purl.obolibrary.org/obo/GO_0045785		
GO:0045786	biolink:BiologicalProcess	negative regulation of cell cycle	Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.		hp.json	downregulation of progression through cell cycle|down regulation of progression through cell cycle|inhibition of progression through cell cycle|down-regulation of progression through cell cycle|negative regulation of progression through cell cycle|negative regulation of cell cycle progression	http://purl.obolibrary.org/obo/GO_0045786		
GO:0070727	biolink:BiologicalProcess	cellular macromolecule localization	Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.		hp.json	cellular macromolecule localisation	http://purl.obolibrary.org/obo/GO_0070727		
UBERON:0005709	biolink:AnatomicalEntity	upper jaw incisor epithelium	A dental epithelium that is part of a upper jaw incisor.	EMAPA:17940|EHDAA2:0002122	hp.json		http://purl.obolibrary.org/obo/UBERON_0005709		
GO:0006109	biolink:BiologicalProcess	regulation of carbohydrate metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates.		hp.json	regulation of carbohydrate metabolism	http://purl.obolibrary.org/obo/GO_0006109		
UBERON:0005708	biolink:AnatomicalEntity	lower jaw incisor odontogenic papilla	An odontogenic papilla that is part of a lower jaw incisor.	EHDAA2:0001023|EMAPA:17920	hp.json	lower incisor mesenchyme|lower jaw incisor dental papilla	http://purl.obolibrary.org/obo/UBERON_0005708		
GO:0055117	biolink:BiologicalProcess	regulation of cardiac muscle contraction	Any process that modulates the frequency, rate or extent of cardiac muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_0055117		
UBERON:0005707	biolink:AnatomicalEntity	upper jaw incisor odontogenic papilla	An odontogenic papilla that is part of a upper jaw incisor.	EHDAA2:0002123|EMAPA:17941	hp.json	upper incisor mesenchyme|upper jaw incisor dental papilla	http://purl.obolibrary.org/obo/UBERON_0005707		
GO:0055118	biolink:BiologicalProcess	negative regulation of cardiac muscle contraction	Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_0055118		
UBERON:0005705	biolink:AnatomicalEntity	primary palate mesenchyme	Mesenchyme that is part of a developing primary palate.	EHDAA:6968|EHDAA2:0001501|VHOG:0001024|EMAPA:17644	hp.json		http://purl.obolibrary.org/obo/UBERON_0005705		
UBERON:0005704	biolink:AnatomicalEntity	secondary palatal shelf mesenchyme	Mesenchyme that is part of a developing secondary palatal shelf.	VHOG:0001063|EMAPA:17364|EHDAA2:0001366|EHDAA:9287	hp.json	palatal shelf mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005704		
GO:0043134	biolink:BiologicalProcess	regulation of hindgut contraction	Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.		hp.json		http://purl.obolibrary.org/obo/GO_0043134		
GO:0043133	biolink:BiologicalProcess	hindgut contraction	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine.		hp.json		http://purl.obolibrary.org/obo/GO_0043133		
UBERON:7500094	biolink:AnatomicalEntity	tubercle of calcaneus	A raised projection on the calcaneus.		hp.json	calcaneal tubercle|calcaneal tuberosity|tuberosity of calcaneus	http://purl.obolibrary.org/obo/UBERON_7500094		
HP:0040290	biolink:PhenotypicFeature	obsolete Abnormality of skeletal muscles			hp.json		http://purl.obolibrary.org/obo/HP_0040290		
HP:0040291	biolink:PhenotypicFeature	Skeletal muscle steatosis			hp.json	Steatosis of skeletal muscle|Steatosis of skeletal muscles	http://purl.obolibrary.org/obo/HP_0040291		
HP:0040294	biolink:PhenotypicFeature	Duplicated tongue			hp.json	Tongue duplicated|Tongue duplication|Duplication of tongue	http://purl.obolibrary.org/obo/HP_0040294		
GO:0021743	biolink:BiologicalProcess	hypoglossal nucleus development	The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0021743		
HP:0040295	biolink:PhenotypicFeature	Duplication of the upper lip			hp.json	Double upper lip	http://purl.obolibrary.org/obo/HP_0040295		
HP:0040292	biolink:PhenotypicFeature	Left hemiplegia			hp.json	Hemiplegia (left)	http://purl.obolibrary.org/obo/HP_0040292		
UBERON:0005712	biolink:AnatomicalEntity	midgut duodenum mesentery	A mesentery of duodenum that is part of a midgut.	EHDAA2:0001193	hp.json		http://purl.obolibrary.org/obo/UBERON_0005712		
UBERON:0005711	biolink:AnatomicalEntity	foregut duodenum mesentery	A mesentery of duodenum that is part of a foregut.	EHDAA2:0000564	hp.json		http://purl.obolibrary.org/obo/UBERON_0005711		
HP:0040293	biolink:PhenotypicFeature	Right hemiplegia			hp.json	Hemiplegia (right)	http://purl.obolibrary.org/obo/HP_0040293		
UBERON:0005710	biolink:AnatomicalEntity	lower jaw incisor epithelium	A dental epithelium that is part of a lower jaw incisor.	EHDAA2:0001022|EMAPA:17919	hp.json		http://purl.obolibrary.org/obo/UBERON_0005710		
HP:0040298	biolink:PhenotypicFeature	Hyperplasia of the endometrium			hp.json	Hyperplastic endometrium	http://purl.obolibrary.org/obo/HP_0040298		
HP:0040299	biolink:PhenotypicFeature	Decreased circulating free fatty acid level			hp.json	Low fatty acids level	http://purl.obolibrary.org/obo/HP_0040299		
HP:0040296	biolink:PhenotypicFeature	Abnormal location of the eyebrow	Anomalous anatomical placement of the eyebrow.		hp.json	Abnormally placed eyebrows|Abnormal location of eyebrows	http://purl.obolibrary.org/obo/HP_0040296		
HP:0040297	biolink:PhenotypicFeature	Preauricular cyst	Preauricular sinus is an occasional finding and most frequently appears as a small pit close to the anterior margin of the ascending portion of the helix. The opening has also been reported along the postero superior margin of the helix, the tragus or the lobule. Preauricular sinus may lead to the formation of a subcutaneous cyst that is intimately related to the tragal cartilage and the anterior crus of the helix.		hp.json		http://purl.obolibrary.org/obo/HP_0040297		
PR:000020497	biolink:Protein	lactotransferrin proteolytic cleavage product	A lactotransferrin that has been processed by proteolytic cleavage.		hp.json	LTF/ClvPrd	http://purl.obolibrary.org/obo/PR_000020497		
GO:0006111	biolink:BiologicalProcess	regulation of gluconeogenesis	Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.		hp.json	regulation of gluconeogenesis involved in cellular glucose homeostasis|regulation of glucose biosynthesis|regulation of glucose biosynthetic process	http://purl.obolibrary.org/obo/GO_0006111		
GO:0006112	biolink:NamedThing	energy reserve metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0006112		
GO:0006110	biolink:BiologicalProcess	regulation of glycolytic process	Any process that modulates the frequency, rate or extent of glycolysis.		hp.json	regulation of glycolysis involved in cellular glucose homeostasis	http://purl.obolibrary.org/obo/GO_0006110		
GO:0043143	biolink:BiologicalProcess	regulation of translation by machinery localization	Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.		hp.json	translational machinery localization|translational protein localization|establishment and maintenance of translational machinery localization|regulation of translation by machinery localisation|establishment and maintenance of translational protein localization	http://purl.obolibrary.org/obo/GO_0043143		
GO:0021732	biolink:BiologicalProcess	midbrain-hindbrain boundary maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.		hp.json	isthmus maturation|MHB maturation	http://purl.obolibrary.org/obo/GO_0021732		
UBERON:0005702	biolink:AnatomicalEntity	optic eminence mesenchyme	Mesenchyme that is part of a optic eminence.	VHOG:0001073|EMAPA:16324|RETIRED_EHDAA2:0001310|EHDAA:942	hp.json		http://purl.obolibrary.org/obo/UBERON_0005702		
UBERON:0005701	biolink:AnatomicalEntity	lower jaw molar odontogenic papilla	An odontogenic papilla that is part of a lower jaw molar.	EHDAA2:0001027|EHDAA:8015|EMAPA:17923	hp.json	lower molar mesenchyme|lower jaw molar dental papilla	http://purl.obolibrary.org/obo/UBERON_0005701		
GO:0055127	biolink:BiologicalProcess	vibrational conductance of sound to the inner ear	The transmission of vibrations via ossicles to the inner ear.		hp.json		http://purl.obolibrary.org/obo/GO_0055127		
UBERON:0005700	biolink:AnatomicalEntity	upper jaw molar odontogenic papilla	An odontogenic papilla that is part of a upper jaw molar.	EHDAA2:0002127|EMAPA:17944|EHDAA:8051	hp.json	upper molar mesenchyme|upper jaw molar dental papilla	http://purl.obolibrary.org/obo/UBERON_0005700		
GO:0055123	biolink:BiologicalProcess	digestive system development	The process whose specific outcome is the progression of the digestive system over time, from its formation to the mature structure. The digestive system is the entire structure in which digestion takes place. Digestion is all of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.		hp.json		http://purl.obolibrary.org/obo/GO_0055123		
GO:0021720	biolink:BiologicalProcess	superior olivary nucleus formation	The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.		hp.json		http://purl.obolibrary.org/obo/GO_0021720		
GO:0021722	biolink:BiologicalProcess	superior olivary nucleus maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.		hp.json	superior olive maturation	http://purl.obolibrary.org/obo/GO_0021722		
GO:0043168	biolink:MolecularActivity	anion binding	Binding to an anion, a charged atom or group of atoms with a net negative charge.		hp.json		http://purl.obolibrary.org/obo/GO_0043168		
GO:0043167	biolink:MolecularActivity	ion binding	Binding to an ion, a charged atoms or groups of atoms.		hp.json	atom binding	http://purl.obolibrary.org/obo/GO_0043167		goslim_pir|goslim_chembl|goslim_metagenomics|goslim_yeast
GO:0043169	biolink:MolecularActivity	cation binding	Binding to a cation, a charged atom or group of atoms with a net positive charge.		hp.json		http://purl.obolibrary.org/obo/GO_0043169		
GO:0021718	biolink:BiologicalProcess	superior olivary nucleus development	The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.		hp.json	superior olive development	http://purl.obolibrary.org/obo/GO_0021718		
GO:0021719	biolink:BiologicalProcess	superior olivary nucleus morphogenesis	The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.		hp.json	superior olive morphogenesis	http://purl.obolibrary.org/obo/GO_0021719		
HP:0040258	biolink:PhenotypicFeature	Hypoplastic nasopharyngeal adenoids	Underdevelopment of the nasopharyngeal adenoids.	UMLS:C4280691	hp.json	Underdeveloped nasopharyngeal adenoids	http://purl.obolibrary.org/obo/HP_0040258		
HP:0040259	biolink:PhenotypicFeature	Aplastic nasopharyngeal adenoids	Absence of the nasopharyngeal adenoids as a developmental defect.	UMLS:C4280690	hp.json		http://purl.obolibrary.org/obo/HP_0040259		
HP:0040256	biolink:PhenotypicFeature	Aplastic/Hypoplastic nasopharyngeal adenoids	Absence or underdevelopment of the nasopharyngeal adenoids.	UMLS:C4280290	hp.json	Adenoids small or absent	http://purl.obolibrary.org/obo/HP_0040256		
HP:0040257	biolink:PhenotypicFeature	Abnormal size of nasopharyngeal adenoids	A deviation in the size of nasopharyngeal adenoids.	UMLS:C4280692	hp.json		http://purl.obolibrary.org/obo/HP_0040257		
PR:P35456	biolink:Protein	urokinase plasminogen activator surface receptor (mouse)	A urokinase plasminogen activator surface receptor that is encoded in the genome of mouse.	UniProtKB:P35456	hp.json	uPAR (mouse)|U-PAR (mouse)|mPLAUR|Plaur|CD87 (mouse)	http://purl.obolibrary.org/obo/PR_P35456		
CHEBI:83972	biolink:ChemicalSubstance	3-methyl fatty acid anion	A methyl-branched fatty acid anion obtained by deprotonation of the carboxy group of any 3-methyl fatty acid; major species at pH 7.3.		hp.json	3-methyl-branched fatty acid(1-)|3-methyl fatty acid|3-methyl-branched fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_83972		3_STAR
HP:0040250	biolink:PhenotypicFeature	Reduced prothrombin antigen	Reduced prothrombin antigen as measured by ELISA assay. Prothrombin is a vitamin K-dependent coagulation factor that is proteolytically cleaved to form thrombin.	UMLS:C4280698	hp.json		http://purl.obolibrary.org/obo/HP_0040250		
HP:0040251	biolink:PhenotypicFeature	Hand dimple	A cutaneous indentation resulting from tethering of the skin to underlying structures (bone) of the hand.	UMLS:C4280697	hp.json	Hand dimples	http://purl.obolibrary.org/obo/HP_0040251		
HP:0040254	biolink:PhenotypicFeature	Decreased size of the clitoris		UMLS:C4280694	hp.json		http://purl.obolibrary.org/obo/HP_0040254		
HP:0040255	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the clitoris		UMLS:C4280693	hp.json		http://purl.obolibrary.org/obo/HP_0040255		
HP:0040252	biolink:PhenotypicFeature	Abnormal size of the clitoris		UMLS:C4280696	hp.json		http://purl.obolibrary.org/obo/HP_0040252		
HP:0040253	biolink:PhenotypicFeature	Increased size of the clitoris		UMLS:C4280695	hp.json		http://purl.obolibrary.org/obo/HP_0040253		
HP:0040269	biolink:PhenotypicFeature	Blocked Eustachian tube		UMLS:C0149508|SNOMEDCT_US:48145001	hp.json	Obstruction of Eustachian tube	http://purl.obolibrary.org/obo/HP_0040269		
HP:0040267	biolink:PhenotypicFeature	Distal upper limb muscle hypertrophy		UMLS:C4280685	hp.json		http://purl.obolibrary.org/obo/HP_0040267		
HP:0040268	biolink:PhenotypicFeature	Recurrent infections of the middle ear	Increased susceptibility to middle ear infections, as manifested by recurrent episodes of middle ear infections	UMLS:C0747085	hp.json		http://purl.obolibrary.org/obo/HP_0040268		
CHEBI:83982	biolink:ChemicalSubstance	L-glutamic acid derivative	A proteinogenic amino acid derivative resulting from reaction of L-glutamic acid at the amino group or either of the carboxy groups, or from the replacement of any hydrogen of L-glutamic acid by a heteroatom.		hp.json	L-glutamic acid derivatives	http://purl.obolibrary.org/obo/CHEBI_83982		3_STAR
PR:P35461	biolink:Protein	lymphocyte antigen 6G (mouse)	A lymphocyte antigen 6G that is encoded in the genome of mouse.	UniProtKB:P35461	hp.json	Ly-6G (mouse)|Ly6g|mLy6g|Ly-6G.1 (mouse)	http://purl.obolibrary.org/obo/PR_P35461		
HP:0040261	biolink:PhenotypicFeature	Increased size of nasopharyngeal adenoids	An abnormal increase in the size of nasopharyngeal adenoids.	UMLS:C0455938|SNOMEDCT_US:111591002|SNOMEDCT_US:276442006|UMLS:C0149825	hp.json	Adenoids large|Adenoid hypertrophy	http://purl.obolibrary.org/obo/HP_0040261		
HP:0040262	biolink:PhenotypicFeature	Glue ear	Middle ear is filled with glue-like fluid instead of air.	UMLS:C0029883|SNOMEDCT_US:78868004|MSH:D010034	hp.json		http://purl.obolibrary.org/obo/HP_0040262		
HP:0040260	biolink:PhenotypicFeature	Decreased size of nasopharyngeal adenoids	An abnormal decrease in the size of nasopharyngeal adenoids.	UMLS:C4280689	hp.json		http://purl.obolibrary.org/obo/HP_0040260		
GO:0031175	biolink:BiologicalProcess	neuron projection development	The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).		hp.json	neurite growth|neurite outgrowth|neurite formation|neurite biosynthesis|neurite development	http://purl.obolibrary.org/obo/GO_0031175		
HP:0040265	biolink:PhenotypicFeature	Upper limb muscle hypertrophy	Abnormal increase in muscle size and mass of one or both arms not due to training.	UMLS:C4280687	hp.json		http://purl.obolibrary.org/obo/HP_0040265		
HP:0040266	biolink:PhenotypicFeature	Proximal upper limb muscle hypertrophy		UMLS:C4280686	hp.json		http://purl.obolibrary.org/obo/HP_0040266		
HP:0040263	biolink:PhenotypicFeature	Jaw ankylosis		UMLS:C4280688|SNOMEDCT_US:285466001|UMLS:C0563350	hp.json	Difficulty opening mouth	http://purl.obolibrary.org/obo/HP_0040263		
HP:0040264	biolink:PhenotypicFeature	Jaw pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the jaw.	UMLS:C0236000|SNOMEDCT_US:274667000	hp.json	Jaw pain	http://purl.obolibrary.org/obo/HP_0040264		
HP:0040278	biolink:PhenotypicFeature	Prolactinoma	A benign tumor (adenoma) of the pituitary gland		hp.json		http://purl.obolibrary.org/obo/HP_0040278		
UBERON:0015099	biolink:AnatomicalEntity	distal tarsal endochondral element	A distal mesopodial endochondral element that is part of a hindlimb.		hp.json	distal tarsal	http://purl.obolibrary.org/obo/UBERON_0015099		
HP:0040279	biolink:PhenotypicFeature	Frequency	Class to represent frequency of phenotypic abnormalities within a patient cohort.		hp.json		http://purl.obolibrary.org/obo/HP_0040279		
UBERON:0015094	biolink:AnatomicalEntity	distal carpal bone 4 cartilage	A distal carpal bone 4 endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015094		
UBERON:0015093	biolink:AnatomicalEntity	distal carpal bone 4 endochondral element			hp.json	distal carpal 4	http://purl.obolibrary.org/obo/UBERON_0015093		
UBERON:0015095	biolink:AnatomicalEntity	distal carpal bone 4 pre-cartilage condensation	A distal carpal bone 4 endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015095		
HP:0003288	biolink:PhenotypicFeature	Mitochondrial propionyl-CoA carboxylase defect		UMLS:C4025634	hp.json	Mitochondrial PCC defect	http://purl.obolibrary.org/obo/HP_0003288		
UBERON:0015090	biolink:AnatomicalEntity	distal carpal bone 3 endochondral element			hp.json	distal carpal 3	http://purl.obolibrary.org/obo/UBERON_0015090		
HP:0040272	biolink:PhenotypicFeature	Hyperintensity of MRI T2 signal of the spinal cord	A region of high intensity (brightness) observed upon magnetic resonance imaging (MRI) scans of the spinal cord.	UMLS:C4280684	hp.json		http://purl.obolibrary.org/obo/HP_0040272		
HP:0040273	biolink:PhenotypicFeature	Adenocarcinoma of the intestines	A malignant epithelial tumor with a glandular organization that originates in the intestines.	UMLS:C4280683|NCIT:C2852	hp.json		http://purl.obolibrary.org/obo/HP_0040273		
HP:0003282	biolink:PhenotypicFeature	Low alkaline phosphatase	Abnormally reduced serum levels of alkaline phosphatase.	UMLS:C1860130	hp.json	Low ALP|Decreased serum alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003282		
HP:0003281	biolink:PhenotypicFeature	Increased circulating ferritin concentration	Increased concentration of ferritin in the blood circulation.	UMLS:C3854388|UMLS:C0743912|UMLS:C0241013	hp.json	High ferritin level|Hyperferritinaemia|Increased ferritin|Elevated serum ferritin|Increased serum ferritin level|Increased plasma ferritin|Hyperferritinemia	http://purl.obolibrary.org/obo/HP_0003281		
UBERON:0015092	biolink:AnatomicalEntity	distal carpal bone 3 pre-cartilage condensation	A distal carpal bone 3 endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015092		
HP:0040270	biolink:PhenotypicFeature	Impaired glucose tolerance	An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral or intravenous administration of glucose.	MP:0005291|UMLS:C0151671	hp.json	Glucose tolerance decreased|Decreased glucose tolerance	http://purl.obolibrary.org/obo/HP_0040270		
UBERON:0015091	biolink:AnatomicalEntity	distal carpal bone 3 cartilage	A distal carpal bone 3 endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015091		
HP:0003287	biolink:PhenotypicFeature	Abnormality of mitochondrial metabolism	A functional anomaly of mitochondria.	UMLS:C4021734	hp.json	Mitochondrial dysfunction	http://purl.obolibrary.org/obo/HP_0003287		
HP:0040276	biolink:PhenotypicFeature	Adenocarcinoma of the colon		NCIT:C2852|UMLS:C0338106	hp.json		http://purl.obolibrary.org/obo/HP_0040276		
HP:0003286	biolink:PhenotypicFeature	Cystathioninemia	An increased concentration of cystathionine in the blood.	UMLS:C0268618|SNOMEDCT_US:6669004	hp.json	High blood cystathionine levels	http://purl.obolibrary.org/obo/HP_0003286		
HP:0040277	biolink:PhenotypicFeature	Neoplasm of the pituitary gland		NCIT:C3262	hp.json		http://purl.obolibrary.org/obo/HP_0040277		
HP:0040274	biolink:PhenotypicFeature	Adenocarcinoma of the small intestine	A malignant epithelial tumor with a glandular organization that originates in the small intestine.	NCIT:C2852|SNOMEDCT_US:424440001|UMLS:C0278803	hp.json		http://purl.obolibrary.org/obo/HP_0040274		
HP:0040275	biolink:PhenotypicFeature	Adenocarcinoma of the large intestine	A malignant epithelial tumor with a glandular organization that originates in the large intestine.	NCIT:C2852|UMLS:C1319315|SNOMEDCT_US:408645001	hp.json		http://purl.obolibrary.org/obo/HP_0040275		
UBERON:0015087	biolink:AnatomicalEntity	distal carpal bone 2 endochondral element			hp.json	distal carpal 2	http://purl.obolibrary.org/obo/UBERON_0015087		
UBERON:0015086	biolink:AnatomicalEntity	distal carpal bone 1 pre-cartilage condensation	A distal carpal bone 1 endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015086		
HP:0040289	biolink:PhenotypicFeature	Cyclic neutropenia	Recurrent episodes of abnormally low levels of neutrophils in the body (neutropenia).		hp.json	CyN	http://purl.obolibrary.org/obo/HP_0040289		
UBERON:0015089	biolink:AnatomicalEntity	distal carpal bone 2 pre-cartilage condensation	A distal carpal bone 2 endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015089		
UBERON:0015088	biolink:AnatomicalEntity	distal carpal bone 2 cartilage	A distal carpal bone 2 endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015088		
UBERON:0015083	biolink:AnatomicalEntity	proximal tarsal bone pre-cartilage condensation	A proximal tarsal endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015083		
UBERON:0015082	biolink:AnatomicalEntity	proximal tarsal cartilage	A proximal tarsal endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015082		
UBERON:0015085	biolink:AnatomicalEntity	distal carpal bone 1 cartilage	A distal carpal bone 1 endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015085		
UBERON:0015084	biolink:AnatomicalEntity	distal carpal bone 1 endochondral element			hp.json	distal carpal 1	http://purl.obolibrary.org/obo/UBERON_0015084		
HP:0040280	biolink:PhenotypicFeature	Obligate	Always present, i.e. in 100% of the cases.	ORPHA:453310	hp.json	Obligate (100%)	http://purl.obolibrary.org/obo/HP_0040280		
HP:0040283	biolink:PhenotypicFeature	Occasional	Present in 5% to 29% of the cases.	ORPHA:453313	hp.json	Occasional (29-5%)	http://purl.obolibrary.org/obo/HP_0040283		
HP:0040284	biolink:PhenotypicFeature	Very rare	Present in 1% to 4% of the cases.	ORPHA:453314	hp.json	Very rare (&lt;4-1%)|Very rare (<4-1%)	http://purl.obolibrary.org/obo/HP_0040284		
HP:0003292	biolink:PhenotypicFeature	Decreased serum leptin	A decreased concentration of leptin in the blood.	UMLS:C1837802	hp.json	Reduced circulating leptin level|Decreased serum leptin	http://purl.obolibrary.org/obo/HP_0003292		
HP:0040281	biolink:PhenotypicFeature	Very frequent	Present in 80% to 99% of the cases.	ORPHA:453311	hp.json	Very frequent (99-80%)	http://purl.obolibrary.org/obo/HP_0040281		
UBERON:0015081	biolink:AnatomicalEntity	proximal tarsal endochondral element	A proximal mesopodial endochondral element that is part of a hindlimb.		hp.json	proximal tarsal	http://purl.obolibrary.org/obo/UBERON_0015081		
HP:0040282	biolink:PhenotypicFeature	Frequent	Present in 30% to 79% of the cases.	ORPHA:453312	hp.json	Frequent (79-30%)	http://purl.obolibrary.org/obo/HP_0040282		
UBERON:0015080	biolink:AnatomicalEntity	proximal carpal bone pre-cartilage condensation	A proximal carpal endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015080		
HP:0003298	biolink:PhenotypicFeature	Spina bifida occulta	The closed form of spina bifida with incomplete closure of a vertebral body with intact overlying skin.	SNOMEDCT_US:76916001|UMLS:C0080174|MSH:D016136	hp.json		http://purl.obolibrary.org/obo/HP_0003298		hposlim_core
HP:0040287	biolink:PhenotypicFeature	Axial muscle atrophy			hp.json		http://purl.obolibrary.org/obo/HP_0040287		
HP:0040288	biolink:PhenotypicFeature	Nasogastric tube feeding	The condition of inability to eat normally treated by placement of a thin tube through the nose into the stomach that is then used to carry food.		hp.json		http://purl.obolibrary.org/obo/HP_0040288		
HP:0003297	biolink:PhenotypicFeature	Hyperlysinuria	An increased concentration of lysine in the urine.	UMLS:C4021733	hp.json	High urine lysine levels|Lysinuria	http://purl.obolibrary.org/obo/HP_0003297		
HP:0040285	biolink:PhenotypicFeature	Excluded	Present in 0% of the cases.	ORPHA:453315	hp.json	Excluded (0%)	http://purl.obolibrary.org/obo/HP_0040285		
HP:0003296	biolink:PhenotypicFeature	Hyperthreoninuria	An increased concentration of threonine in the urine.	UMLS:C2673931	hp.json	High urine threonine levels	http://purl.obolibrary.org/obo/HP_0003296		
HP:0003295	biolink:PhenotypicFeature	obsolete Impaired FSH and LH secretion			hp.json		http://purl.obolibrary.org/obo/HP_0003295		
HP:0040286	biolink:PhenotypicFeature	Abnormal axial muscle morphology	A structural anomaly of the muscles of the trunk and head.		hp.json	Abnormality of axial muscles	http://purl.obolibrary.org/obo/HP_0040286		
HP:0040214	biolink:PhenotypicFeature	Abnormal circulating insulin concentration	An abnormal concentration of insulin in the body.	UMLS:C4073160	hp.json	Abnormal insulin level	http://purl.obolibrary.org/obo/HP_0040214		
HP:0040215	biolink:PhenotypicFeature	obsolete Abnormal circulating insulin level			hp.json		http://purl.obolibrary.org/obo/HP_0040215		
HP:0040212	biolink:PhenotypicFeature	Risus sardonicus	Fixed sarcastic grimace and anxious expression. Caused by spasms of the masseter and other facial muscles.	UMLS:C0343494|SNOMEDCT_US:64314006	hp.json	Rictus grin	http://purl.obolibrary.org/obo/HP_0040212		
HP:0040213	biolink:PhenotypicFeature	Hypopnea	Hypopnea is referring to breathing that is abnormally shallow.	SNOMEDCT_US:386614005|UMLS:C0235546	hp.json	Shallow breathing	http://purl.obolibrary.org/obo/HP_0040213		
HP:0040218	biolink:PhenotypicFeature	Reduced natural killer cell count	Less than normal number of natural killer cells, a type of lymphocyte in the innate immune system with an ability to mediate cytotoxicity and produce cytokines after the ligation of a germline-encoded activation receptor.	UMLS:C1855767	hp.json	Reduced natural killer cell number|Reduced NK cell number	http://purl.obolibrary.org/obo/HP_0040218		
HP:0040219	biolink:PhenotypicFeature	Absent natural killer cells	Lack of natural killer cells, a type of lymphocyte in the innate immune system that contains cytoplasmic granzymes, i.e., small granules with perforin and proteases that allow natural killer cells to form pores in the cell membrane of the target cell through which the granzymes and associated molecules can enter, inducing apoptosis.	UMLS:C4073163	hp.json	Absent NK cells	http://purl.obolibrary.org/obo/HP_0040219		
HP:0040216	biolink:PhenotypicFeature	Hypoinsulinemia	A decreased concentration of insulin in the blood.	UMLS:C2748055	hp.json		http://purl.obolibrary.org/obo/HP_0040216		
HP:0040217	biolink:PhenotypicFeature	Elevated hemoglobin A1c	An increased concentration of hemoglobin A1c (HbA1c), which is the product of nonenzymatic attachment of a hexose molecule to the N-terminal amino acid of the hemoglobin molecule. This reaction is dependent on blood glucose concentration, and therefore reflects the mean glucose concentration over the previous 8 to 12 weeks. The HbA1c level provides a better indication of long-term glycemic control than one-time blood or urinary glucose measurements.	UMLS:C4073162	hp.json	Elevated glycosylated haemoglobin|Elevated haemoglobin A1c|Elevated glycated hemoglobin|Elevated glycated haemoglobin|Elevated glycosylated hemoglobin|Increased HbA1c levels|Elevated HbA1c	http://purl.obolibrary.org/obo/HP_0040217		
HP:0030891	biolink:PhenotypicFeature	Periventricular white matter hyperintensities	Areas of brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the cerebral ventricles.		hp.json	PVWMH	http://purl.obolibrary.org/obo/HP_0030891		
HP:0030892	biolink:PhenotypicFeature	Deep cerebral white matter hyperintensities	Areas of brighter than expected signal on magnetic resonance imaging emanating from locations distant from the ventricular system.		hp.json	DWMH	http://purl.obolibrary.org/obo/HP_0030892		
HP:0030893	biolink:PhenotypicFeature	Abnormal response to short acting pulmonary vasodilator	Pulmonary vasodilator testing is performed during right-heart catheterization and involves a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide. The current definition of a normal (positive) response is a drop in mean pulmonary artery pressure of at least 10 mm Hg (or 20 percent) to below 40 mm Hg.		hp.json		http://purl.obolibrary.org/obo/HP_0030893		
HP:0030894	biolink:PhenotypicFeature	Insufficient response to short acting pulmonary vasodilator	No fall in mean pulmonary arterial pressure (mPAP) falls by at least 10 mmHg to an absolute value less than 40 mmHg without a degradation in cardiac output (CO) in response to a short-acting vasoactive agent such as adenosine, epoprostenol, or inhaled nitric oxide.		hp.json		http://purl.obolibrary.org/obo/HP_0030894		
HP:0030890	biolink:PhenotypicFeature	Hyperintensity of cerebral white matter on MRI	A brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter.		hp.json	White matter hyperintensity	http://purl.obolibrary.org/obo/HP_0030890		
HP:0030899	biolink:PhenotypicFeature	Pruritis on hand	Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the hand.		hp.json		http://purl.obolibrary.org/obo/HP_0030899		
GO:0045719	biolink:NamedThing	negative regulation of glycogen biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0045719		
HP:0030895	biolink:PhenotypicFeature	Abnormal gastrointestinal motility	An anomaly of the muscular contractions that propel food though the gastrointestinal tract.		hp.json	Abnormal GI motility	http://purl.obolibrary.org/obo/HP_0030895		
HP:0030896	biolink:PhenotypicFeature	Abnormal gastrointestinal transit time	A deviation from the normal amount of time required for food to pass through the intestines.		hp.json	Abnormal GI transit time	http://purl.obolibrary.org/obo/HP_0030896		
MPATH:287	biolink:NamedThing	islet cell adenoma	Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0).		hp.json	islet (pancreatic) cell tumor benign|adenomatosis|Adenoma, endocrine pancreas	http://purl.obolibrary.org/obo/MPATH_287		
HP:0030897	biolink:PhenotypicFeature	Decreased intestinal transit time	A reduction in the length of time required for food to pass through the intestines.		hp.json		http://purl.obolibrary.org/obo/HP_0030897		
HP:0030898	biolink:PhenotypicFeature	Pruritis on abdomen	Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the abdomen.		hp.json		http://purl.obolibrary.org/obo/HP_0030898		
HP:0040210	biolink:PhenotypicFeature	Abnormal circulating biopterin concentration	A deviation from the normal concentration of biopterin in the blood circulation.	UMLS:C4073158	hp.json		http://purl.obolibrary.org/obo/HP_0040210		
GO:0031143	biolink:CellularComponent	pseudopodium	A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.	Wikipedia:Pseudopod	hp.json	reticulopodium|axopodium|pseudopod|pseudopodial protrusion|lobopodium	http://purl.obolibrary.org/obo/GO_0031143		goslim_pir
HP:0040211	biolink:PhenotypicFeature	Abnormal skin morphology of the palm	An abnormality of the skin of the palm, that is, the skin of the front of the hand.	UMLS:C4073159	hp.json		http://purl.obolibrary.org/obo/HP_0040211		
HP:0040225	biolink:PhenotypicFeature	Decrease in high molecular weight von Willebrand factor Multimers	A decrease in high molecular weight von Willebrand factor multimers.	UMLS:C4280718	hp.json	Decrease in HMW VWF multimers	http://purl.obolibrary.org/obo/HP_0040225		
HP:0040226	biolink:PhenotypicFeature	Decreased level of heparin co-factor II	An abnormality of coagulation related to a decreased concentration of heparin co-factor II	UMLS:C4280717	hp.json	Heparin co-factor II deficiency	http://purl.obolibrary.org/obo/HP_0040226		
HP:0040223	biolink:PhenotypicFeature	Pulmonary hemorrhage	Pulmonary hemorrhage is a bleeding within the lungs. Older children and adults may spit blood or bloody sputum. Neonates, infants and young children usually do not spit up blood. Anemia, pulmonary infiltrates, increasingling bloody return on BAL and the presence of hemosiderin-laden macrophages in broncho-alveolar lavage (BAL) fluid or lung biopsy can diagnose lung bleeding. Alveolar macrophages contain phagocytosed red blood cells and stain positive for hemosiderin, a product of hemoglobin degradation, after about 48-72 hours following pulmonary hemorraghe. Previous or recurrent bleeding can thus be distinguished from fresh events. A differentiation into local or diffuse is of importance. Also differentiate if pulmonary hemorrhage is due to a primary lung disorder or a manifestation of a systemic disease.	UMLS:C4280720	hp.json	Intrapulmonary hemorrhage|Intrapulmonary haemorrhage|Pulmonary haemorrhage	http://purl.obolibrary.org/obo/HP_0040223		
HP:0040224	biolink:PhenotypicFeature	Abnormality of fibrinolysis	Clincial phenotype characterized by delayed bleeding accelerated break down of blood clot (fibrinolysis)	UMLS:C4280719	hp.json	Abnormality of the fibrinolytic system	http://purl.obolibrary.org/obo/HP_0040224		
HP:0040229	biolink:PhenotypicFeature	Decreased level of thrombomodulin	Thrombomodulin is a cofactor in the thrombin induced activation of Protein C. In the case of deficiency there will be less Protein C and tendency to clot	UMLS:C4255334	hp.json	BDCA-3	http://purl.obolibrary.org/obo/HP_0040229		
HP:0040227	biolink:PhenotypicFeature	Decreased level of histidine-rich glycoprotein	Decrease of these levels result in increased inhibition of fibrinolysis and reduced inhibition of coagulation	UMLS:C4280716	hp.json		http://purl.obolibrary.org/obo/HP_0040227		
HP:0040228	biolink:PhenotypicFeature	Decreased level of plasminogen	A decreased level of Plasminogen	UMLS:C4280715	hp.json	Hypoplasminogenemia	http://purl.obolibrary.org/obo/HP_0040228		
GO:0045721	biolink:BiologicalProcess	negative regulation of gluconeogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.		hp.json	inhibition of gluconeogenesis|downregulation of gluconeogenesis|down-regulation of gluconeogenesis|down regulation of gluconeogenesis	http://purl.obolibrary.org/obo/GO_0045721		
GO:0045722	biolink:BiologicalProcess	positive regulation of gluconeogenesis	Any process that activates or increases the frequency, rate or extent of gluconeogenesis.		hp.json	up-regulation of gluconeogenesis|up regulation of gluconeogenesis|activation of gluconeogenesis|stimulation of gluconeogenesis|upregulation of gluconeogenesis	http://purl.obolibrary.org/obo/GO_0045722		
MPATH:270	biolink:NamedThing	adenoma	A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy.		hp.json		http://purl.obolibrary.org/obo/MPATH_270		
GO:0045727	biolink:BiologicalProcess	positive regulation of translation	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.		hp.json	positive regulation of protein formation|positive regulation of protein biosynthetic process|upregulation of protein biosynthetic process|positive regulation of protein biosynthesis|stimulation of protein biosynthetic process|up regulation of protein biosynthetic process|positive regulation of protein anabolism|up-regulation of protein biosynthetic process|activation of protein biosynthetic process|positive regulation of protein synthesis	http://purl.obolibrary.org/obo/GO_0045727		
GO:0045728	biolink:BiologicalProcess	respiratory burst after phagocytosis	A phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.		hp.json	metabolic burst after phagocytosis|oxidative burst after phagocytosis	http://purl.obolibrary.org/obo/GO_0045728		
GO:0045725	biolink:NamedThing	positive regulation of glycogen biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0045725		
GO:0045724	biolink:BiologicalProcess	positive regulation of cilium assembly	Any process that activates or increases the frequency, rate or extent of the formation of a cilium.		hp.json	up-regulation of cilium assembly|positive regulation of flagellum assembly|up regulation of cilium assembly|activation of cilium assembly|positive regulation of flagellum biogenesis|stimulation of cilium assembly|upregulation of cilium assembly	http://purl.obolibrary.org/obo/GO_0045724		
HP:0040221	biolink:PhenotypicFeature	Hypoplasia of the dental root		UMLS:C4280722	hp.json		http://purl.obolibrary.org/obo/HP_0040221		
HP:0040222	biolink:PhenotypicFeature	Maternal thrombophilia	An increased tendency towards thrombosis in the mother during a pregnancy.	UMLS:C4280721	hp.json		http://purl.obolibrary.org/obo/HP_0040222		
HP:0040220	biolink:PhenotypicFeature	Abnormal size of the dental root		UMLS:C4280723	hp.json		http://purl.obolibrary.org/obo/HP_0040220		
HP:0040236	biolink:PhenotypicFeature	Hyperfibrinolysis	Increased degradation of fibrin, associated with clot instability and bleeding	UMLS:C3805089	hp.json		http://purl.obolibrary.org/obo/HP_0040236		
HP:0040237	biolink:PhenotypicFeature	Impaired binding of factor VIII to VWF	Impaired binding of factor VIII to von Willebrand Factor. This is determined using a modified ELISA assay.	UMLS:C4280710	hp.json	von Willebrand Disease Type II Normandy	http://purl.obolibrary.org/obo/HP_0040237		
HP:0040234	biolink:PhenotypicFeature	Factor XIII subunit B deficiency	Deficiency of factor XIII subunit B, leading to a reduced factor XIII activity. Activated Factor XIII cross-links fibrin polymers solidifying the clot.	MSH:C567688|UMLS:C2750481	hp.json	Reduced factor XIII, subunit B	http://purl.obolibrary.org/obo/HP_0040234		
HP:0040235	biolink:PhenotypicFeature	Leukocyte inclusion bodies	The presence of intraceullar inclusion bodies (aggregates of stainable substances, usually proteins) in leukocytes.	UMLS:C4280711	hp.json	Dohle-like leukocyte inclusion bodies|Inclusion bodies in leukocytes	http://purl.obolibrary.org/obo/HP_0040235		
GO:0031128	biolink:BiologicalProcess	developmental induction	A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).		hp.json		http://purl.obolibrary.org/obo/GO_0031128		
HP:0040238	biolink:PhenotypicFeature	Impaired neutrophil chemotaxis	An impairment of the migration of neutrophils towards chemoattractants as part of the innate immune response	UMLS:C4280709	hp.json	Neutrophil migratory defect	http://purl.obolibrary.org/obo/HP_0040238		
HP:0040239	biolink:PhenotypicFeature	Increased plasma vitamin K epoxide after vitamin K supplementation	Increased plasma vitamin K epoxide after vitamin K supplementation is present in VKCFD (vitamin K-dependent clotting factor deficiency) type 2, but not in VKCFD type 1.	UMLS:C4280708	hp.json		http://purl.obolibrary.org/obo/HP_0040239		
GO:0045730	biolink:BiologicalProcess	respiratory burst	A phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.	Wikipedia:Respiratory_burst	hp.json	metabolic burst|oxidative burst	http://purl.obolibrary.org/obo/GO_0045730		
GO:0006165	biolink:BiologicalProcess	nucleoside diphosphate phosphorylation	The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate.		hp.json		http://purl.obolibrary.org/obo/GO_0006165		
GO:0006163	biolink:BiologicalProcess	purine nucleotide metabolic process	The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.		hp.json	purine metabolism|purine metabolic process|purine nucleotide metabolism	http://purl.obolibrary.org/obo/GO_0006163		
GO:0045738	biolink:BiologicalProcess	negative regulation of DNA repair	Any process that stops, prevents, or reduces the frequency, rate or extent of DNA repair.		hp.json	down regulation of DNA repair|inhibition of DNA repair|down-regulation of DNA repair|downregulation of DNA repair	http://purl.obolibrary.org/obo/GO_0045738		
GO:0045739	biolink:BiologicalProcess	positive regulation of DNA repair	Any process that activates or increases the frequency, rate or extent of DNA repair.		hp.json	upregulation of DNA repair|up regulation of DNA repair|stimulation of DNA repair|activation of DNA repair|up-regulation of DNA repair	http://purl.obolibrary.org/obo/GO_0045739		
MPATH:267	biolink:NamedThing	glandular tumor	Neoplasms derived from glandular epithelial cells.		hp.json		http://purl.obolibrary.org/obo/MPATH_267		
GO:0031122	biolink:BiologicalProcess	cytoplasmic microtubule organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.		hp.json	cytoplasmic microtubule organisation|cytoplasmic microtubule organization and biogenesis	http://purl.obolibrary.org/obo/GO_0031122		
HP:0040232	biolink:PhenotypicFeature	Delayed onset bleeding	Abnormal bleeding related to a procedure or trauma which does not start at the time of the initial insult, but after delay by at least 24 hours.	UMLS:C4280712	hp.json		http://purl.obolibrary.org/obo/HP_0040232		
HP:0040233	biolink:PhenotypicFeature	Factor XIII subunit A deficiency	Deficiency of factor XIII subunit A, leading to a reduced factor XIII activity. Activated Factor XIII cross-links fibrin polymers solidifying the clot.	MSH:C567691|UMLS:C2750514	hp.json	Reduced factor XIII, subunit A	http://purl.obolibrary.org/obo/HP_0040233		
HP:0040230	biolink:PhenotypicFeature	Decreased level of tissue plasminogen activator	The tPA protein catalyzes the conversion of plasiminogen to plasmin, and thus break down of clots. When there is a deficiency there will be an increase of thrombosis	UMLS:C4280714	hp.json	Decreased level of tPA	http://purl.obolibrary.org/obo/HP_0040230		
HP:0040231	biolink:PhenotypicFeature	Abnormal onset of bleeding		UMLS:C4280713	hp.json		http://purl.obolibrary.org/obo/HP_0040231		
HP:0040247	biolink:PhenotypicFeature	Reduced euglobulin clot lysis time	Abnormally decreased length of time required for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. This test is a clinical assay used to measure fibrinolysis. The euglobulin fraction of plasma is precipitated and used to form clot by addition of thrombin; after clot forms the rate of clot breakdown (fibrinolysis) can be monitored.	UMLS:C4280701	hp.json		http://purl.obolibrary.org/obo/HP_0040247		
HP:0040248	biolink:PhenotypicFeature	Reduced plasminogen activator inhibitor 1 activity	Reduced activity of plasminogen activator inhibitor 1. This protein down-regulates fibrinolysis in the circulation by inhibiting the two major plasminogen activators: tissue-plasminogen activator and urokinase-plasminogen activator.	UMLS:C4280700	hp.json		http://purl.obolibrary.org/obo/HP_0040248		
HP:0040245	biolink:PhenotypicFeature	Reduced alpha-2-antiplasmin activity	Reduced activity of alpha-2-antiplasmin. This protein inactivates the protease plasmin that drives fibrinolysis.	UMLS:C4280703	hp.json		http://purl.obolibrary.org/obo/HP_0040245		
HP:0040246	biolink:PhenotypicFeature	Reduced antithrombin antigen	Reduced antithrombin antigen. A reduced level of antithrombin may lead to an increased risk of thrombus formation.	UMLS:C4280702	hp.json		http://purl.obolibrary.org/obo/HP_0040246		
GO:0031117	biolink:BiologicalProcess	positive regulation of microtubule depolymerization	Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.		hp.json	upregulation of microtubule depolymerization|microtubule destabilization|stimulation of microtubule depolymerization|up regulation of microtubule depolymerization|positive regulation of microtubule catastrophe|positive regulation of microtubule disassembly|up-regulation of microtubule depolymerization|activation of microtubule depolymerization	http://purl.obolibrary.org/obo/GO_0031117		
GO:0031115	biolink:BiologicalProcess	negative regulation of microtubule polymerization	Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.		hp.json	inhibition of microtubule polymerization|down-regulation of microtubule polymerization|downregulation of microtubule polymerization|down regulation of microtubule polymerization	http://purl.obolibrary.org/obo/GO_0031115		
HP:0040249	biolink:PhenotypicFeature	Reduced plasminogen activator inhibitor 1 antigen	Reduced level of plasminogen activator inhibitor 1 antigen.	UMLS:C4280699	hp.json		http://purl.obolibrary.org/obo/HP_0040249		
GO:0031116	biolink:BiologicalProcess	positive regulation of microtubule polymerization	Any process that activates or increases the frequency, rate or extent of microtubule polymerization.		hp.json	upregulation of microtubule polymerization|up regulation of microtubule polymerization|stimulation of microtubule polymerization|up-regulation of microtubule polymerization|activation of microtubule polymerization	http://purl.obolibrary.org/obo/GO_0031116		
GO:0045744	biolink:BiologicalProcess	negative regulation of G protein-coupled receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway.		hp.json	negative regulation of G protein coupled receptor protein signaling pathway|down regulation of G-protein coupled receptor protein signaling pathway|inhibition of G-protein coupled receptor protein signaling pathway|down-regulation of G-protein coupled receptor protein signaling pathway|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of GPCR protein signalling pathway|negative regulation of G-protein-coupled receptor protein signalling pathway|negative regulation of GPCR protein signaling pathway|negative regulation of G-protein coupled receptor protein signalling pathway|negative regulation of G protein coupled receptor protein signalling pathway|downregulation of G-protein coupled receptor protein signaling pathway	http://purl.obolibrary.org/obo/GO_0045744		
MPATH:254	biolink:NamedThing	complex tumor	Tumors showing multiple histological componants/differentiation.		hp.json		http://purl.obolibrary.org/obo/MPATH_254		
GO:0045745	biolink:BiologicalProcess	positive regulation of G protein-coupled receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of G protein-coupled receptor signaling pathway activity.		hp.json	activation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein-coupled receptor protein signalling pathway|positive regulation of GPCR protein signalling pathway|positive regulation of G-protein coupled receptor protein signalling pathway|upregulation of G-protein coupled receptor protein signaling pathway|positive regulation of G protein coupled receptor protein signaling pathway|positive regulation of G protein coupled receptor protein signalling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|up regulation of G-protein coupled receptor protein signaling pathway|stimulation of G-protein coupled receptor protein signaling pathway|positive regulation of GPCR protein signaling pathway|positive regulation of G-protein-coupled receptor protein signaling pathway|up-regulation of G-protein coupled receptor protein signaling pathway	http://purl.obolibrary.org/obo/GO_0045745		
GO:0031113	biolink:BiologicalProcess	regulation of microtubule polymerization	Any process that modulates the frequency, rate or extent of microtubule polymerization.		hp.json		http://purl.obolibrary.org/obo/GO_0031113		
HP:0040240	biolink:PhenotypicFeature	Increased ratio of VWF propeptide to VWF antigen	An increased VWF propeptide to VWF antigen indicates that deficiency of VWF is not due to impaired synthesis but due to rapid clearance. The VWF propeptide is measured by ELISA.	UMLS:C4280707	hp.json		http://purl.obolibrary.org/obo/HP_0040240		
GO:0031114	biolink:BiologicalProcess	regulation of microtubule depolymerization	Any process that modulates the frequency, rate or extent of microtubule depolymerization.		hp.json	regulation of microtubule disassembly	http://purl.obolibrary.org/obo/GO_0031114		
GO:0031111	biolink:BiologicalProcess	negative regulation of microtubule polymerization or depolymerization	Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.		hp.json	downregulation of microtubule polymerization or depolymerization|down regulation of microtubule polymerization or depolymerization|inhibition of microtubule polymerization or depolymerization|down-regulation of microtubule polymerization or depolymerization	http://purl.obolibrary.org/obo/GO_0031111		
GO:0031112	biolink:BiologicalProcess	positive regulation of microtubule polymerization or depolymerization	Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization.		hp.json	up regulation of microtubule polymerization or depolymerization|stimulation of microtubule polymerization or depolymerization|up-regulation of microtubule polymerization or depolymerization|activation of microtubule polymerization or depolymerization|upregulation of microtubule polymerization or depolymerization	http://purl.obolibrary.org/obo/GO_0031112		
HP:0040243	biolink:PhenotypicFeature	Prolonged euglobulin clot lysis time	Abnormally increased length of time required for an in vitro clot to dissolve in the absence of the normal plasmin inhibitors. This test is a clinical assay used to measure fibrinolysis. The euglobulin fraction of plasma is precipitated and used to form clot by addition of thrombin; after clot forms the rate of clot breakdown (fibrinolysis) can be monitored.	UMLS:C4280705	hp.json		http://purl.obolibrary.org/obo/HP_0040243		
GO:0031110	biolink:BiologicalProcess	regulation of microtubule polymerization or depolymerization	Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.		hp.json		http://purl.obolibrary.org/obo/GO_0031110		
HP:0040244	biolink:PhenotypicFeature	Prolonged Russell's viper venom time	Increased time to coagulation in the Russell's viper venom assay	UMLS:C4280704	hp.json		http://purl.obolibrary.org/obo/HP_0040244		
HP:0040241	biolink:PhenotypicFeature	Increased RIPA	Increased platelet agglutination in response to low-dose ristocetin	UMLS:C4280706	hp.json		http://purl.obolibrary.org/obo/HP_0040241		
HP:0040242	biolink:PhenotypicFeature	Muscle hemorrhage	Bleeding occuring within a muscle	SNOMEDCT_US:95422003|UMLS:C0151702	hp.json	Muscle haemorrhage	http://purl.obolibrary.org/obo/HP_0040242		
UBERON:0015152	biolink:AnatomicalEntity	gland of ocular region	A gland that is typically found in or near the orbital region, in or around either the medial or lateral canthi, and is typically associated with secretions onto the eyeball or associated ducts. Includes the Harderian, nictitans and lacrimal glands.		hp.json	orbital gland|ocular gland	http://purl.obolibrary.org/obo/UBERON_0015152		
UBERON:0015155	biolink:AnatomicalEntity	conjunctival space	An anatomical space that is enclosed by a conjunctiva.	FMA:59083	hp.json	subbrillar space|cavity of conjunctival sac|conjunctival sac cavity|subconjunctival space	http://purl.obolibrary.org/obo/UBERON_0015155		
UBERON:0015154	biolink:AnatomicalEntity	lateral gland of orbital region	A gland that is located in or around the ocular region, nearer the outer canthi.		hp.json	lateral ocular gland|lateral orbital gland	http://purl.obolibrary.org/obo/UBERON_0015154		
CHEBI:22984	biolink:ChemicalSubstance	calcium atom		DrugBank:DB01373|WebElements:Ca|KEGG:C00076|CAS:7440-70-2	hp.json	Ca|Ca|20Ca|calcium|Kalzium|calcium|calcio|Calcium	http://purl.obolibrary.org/obo/CHEBI_22984		3_STAR
UBERON:0015150	biolink:AnatomicalEntity	dorsal hair	A strand of hair that is part of a dorsum.	FMA:54320	hp.json	back hair|dorsal coat hair|hair of back	http://purl.obolibrary.org/obo/UBERON_0015150		
HP:0030850	biolink:PhenotypicFeature	Abnormal pulse pressure	An anomaly of the pulse pressure, which is defined as the systolic pressured minus the diastolic pressure.	UMLS:C0855322	hp.json		http://purl.obolibrary.org/obo/HP_0030850		
UBERON:0015156	biolink:AnatomicalEntity	terminal branch of ophthalmic artery	The two terminal branches of the ophthalmic artery in humans are the dorsal nasal artery and the supratrochlear artery.	FMA:51956	hp.json		http://purl.obolibrary.org/obo/UBERON_0015156		
HP:0030855	biolink:PhenotypicFeature	Anterior staphyloma	A localized defect in the anterior eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure.	UMLS:C0339206|SNOMEDCT_US:231888000	hp.json		http://purl.obolibrary.org/obo/HP_0030855		
HP:0003225	biolink:PhenotypicFeature	Reduced coagulation factor V activity	Decreased activity of coagulation factor V.	SNOMEDCT_US:4320005|SNOMEDCT_US:88776002|MSH:D005166|UMLS:C0015499	hp.json	Factor V deficiency|Reduced factor V activity	http://purl.obolibrary.org/obo/HP_0003225		
HP:0030856	biolink:PhenotypicFeature	Posterior staphyloma	A localized defect in the posterior eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure.	SNOMEDCT_US:87819007|UMLS:C0155360	hp.json		http://purl.obolibrary.org/obo/HP_0030856		
HP:0003224	biolink:PhenotypicFeature	Increased cellular sensitivity to UV light		UMLS:C1857707	hp.json		http://purl.obolibrary.org/obo/HP_0003224		
HP:0030857	biolink:PhenotypicFeature	Eye movement-induced pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the eye that is worse in certain directions of gaze and during prolonged gaze holding.	UMLS:C4280742	hp.json		http://purl.obolibrary.org/obo/HP_0030857		
HP:0003223	biolink:PhenotypicFeature	Decreased methylcobalamin	Decreased concentration of methylcobalamin. Methylcobalamin is a form of vitamin B12.	UMLS:C4021736	hp.json	Methylcobalamin deficiency	http://purl.obolibrary.org/obo/HP_0003223		
HP:0030858	biolink:PhenotypicFeature	Addictive behavior	A recurrent pattern of behavior that is characeterized by the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the person or to others. The repetitive engagement in these behaviors ultimately interferes with functioning in other domains.	SNOMEDCT_US:32709003|UMLS:C0085281|MSH:D016739	hp.json	Addictive behaviour	http://purl.obolibrary.org/obo/HP_0030858		
HP:0030851	biolink:PhenotypicFeature	Low pulse pressure	Reduced amplitude of the pulse pressure (systolic blood pressure minus diastolic blood pressure).	UMLS:C4280743	hp.json		http://purl.obolibrary.org/obo/HP_0030851		
HP:0005885	biolink:PhenotypicFeature	Absent ossification of cervical vertebral bodies	A lack of bone mineralization of one or more body of cervical vertebra.	UMLS:C4025115	hp.json		http://purl.obolibrary.org/obo/HP_0005885		
HP:0030852	biolink:PhenotypicFeature	High pulse pressure	Increased amplitude of the pulse pressure (systolic blood pressure minus diastolic blood pressure).	UMLS:C0855323	hp.json		http://purl.obolibrary.org/obo/HP_0030852		
HP:0003228	biolink:PhenotypicFeature	Hypernatremia	An abnormally increased sodium concentration in the blood.	SNOMEDCT_US:286926003|MSH:D006955|UMLS:C0020488|SNOMEDCT_US:39355002	hp.json	High blood sodium levels	http://purl.obolibrary.org/obo/HP_0003228		
HP:0030853	biolink:PhenotypicFeature	Heterotaxy	An abnormality in which the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body.	UMLS:C0266642|Fyler:190|SNOMEDCT_US:14821001|SNOMEDCT_US:24614000|MSH:D059446|Fyler:0190	hp.json	Heterotaxia	http://purl.obolibrary.org/obo/HP_0030853		
HP:0005886	biolink:PhenotypicFeature	Aphalangy of the hands	Absence of a digit or of one or more phalanges of a finger.	UMLS:C4025114	hp.json		http://purl.obolibrary.org/obo/HP_0005886		
HP:0003226	biolink:PhenotypicFeature	Rectilinear intracellular accumulation of autofluorescent lipopigment storage material	An intracellular accumulation of autofluorescent lipopigment storage material in a straight or rectilinear pattern.	UMLS:C1850447	hp.json	Rectilinear profiles ultrastructurally	http://purl.obolibrary.org/obo/HP_0003226		
HP:0030854	biolink:PhenotypicFeature	Scleral staphyloma	A staphyloma is a localized defect in the eye wall with protrusion of uveal tissue due to alterations in scleral thickness and structure.	SNOMEDCT_US:111534007|UMLS:C0155359	hp.json	Staphyloma	http://purl.obolibrary.org/obo/HP_0030854		
HP:0005880	biolink:PhenotypicFeature	Metacarpophalangeal synostosis	Fusion of a metacarpal bone with the proximal phalanx of the finger distal to it across the corresponding metacarpophalangeal joint.	UMLS:C4025117	hp.json	Fused long bone of hand with innermost finger bone	http://purl.obolibrary.org/obo/HP_0005880		
HP:0005881	biolink:PhenotypicFeature	Spinal instability		UMLS:C0410648|SNOMEDCT_US:240220009	hp.json		http://purl.obolibrary.org/obo/HP_0005881		
HP:0005882	biolink:PhenotypicFeature	Dermatoglyphic variants		UMLS:C4025116	hp.json		http://purl.obolibrary.org/obo/HP_0005882		
HP:0030859	biolink:PhenotypicFeature	Anti-topoisomerase I antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against topoisomerase I.	UMLS:C4280741	hp.json	Top1 antibody positivity|Topoisomerase (DNA) I antibody positivity|Anti-Scl-70 antibody positivity	http://purl.obolibrary.org/obo/HP_0030859		
HP:0003221	biolink:PhenotypicFeature	Chromosomal breakage induced by crosslinking agents	Increased amount of chromosomal breaks in cultured blood lymphocytes or other cells induced by treatment with DNA cross-linking agents such as diepoxybutane and mitomycin C.	UMLS:C4021737	hp.json	Chromosomal breakage induced by mitomycin C|Chromosomal breakage induced by diepoxybutane	http://purl.obolibrary.org/obo/HP_0003221		
HP:0003220	biolink:PhenotypicFeature	Abnormality of chromosome stability	A type of chromosomal aberration characterised by reduced resistance of chromosomes to change or deterioration.	UMLS:C0376628|MSH:D019457|UMLS:C1859424	hp.json		http://purl.obolibrary.org/obo/HP_0003220		
UBERON:0015142	biolink:AnatomicalEntity	falciform fat	A large fat pad that is located at the base of the abdominal wall, in the falciform ligament of the liver.		hp.json	falciform fat depot|falciform ligament fat pad	http://purl.obolibrary.org/obo/UBERON_0015142		
UBERON:0015144	biolink:AnatomicalEntity	autopod hair	A strand of hair that is part of a autopod region.		hp.json	hand/foot hair|hair of hand/foot|paw hair	http://purl.obolibrary.org/obo/UBERON_0015144		
UBERON:0015143	biolink:AnatomicalEntity	mesenteric fat pad	Encapsulated adipose tissue associated with the mesentery.		hp.json	mesenteric fat depot	http://purl.obolibrary.org/obo/UBERON_0015143		
UBERON:0015149	biolink:AnatomicalEntity	ventral hair	A strand of hair that is part of a ventrum.		hp.json	ventral coat hair	http://purl.obolibrary.org/obo/UBERON_0015149		
HP:0030860	biolink:PhenotypicFeature	Abnormal CSF amyloid level	Abnormal concentration of amyloid in the cerebrospinal fluid (CSF).	UMLS:C4280740	hp.json	Abnormal CSF A[beta]42 level	http://purl.obolibrary.org/obo/HP_0030860		
HP:0030861	biolink:PhenotypicFeature	Decreased CSF amyloid level	Reduced concentration of amyloid in the cerebrospinal fluid (CSF).	UMLS:C4280739	hp.json		http://purl.obolibrary.org/obo/HP_0030861		
UBERON:0015146	biolink:AnatomicalEntity	manus hair	A strand of hair that is part of a manus.		hp.json	hair of hand|front paw hair|hand hair	http://purl.obolibrary.org/obo/UBERON_0015146		
UBERON:0015145	biolink:AnatomicalEntity	pes hair	A strand of hair that is part of a pes.		hp.json	hind foot hair|hind paw hair|hair of foot|foot hair	http://purl.obolibrary.org/obo/UBERON_0015145		
UBERON:0015148	biolink:AnatomicalEntity	tail hair	A strand of hair that is part of a tail.	EMAPA:37971	hp.json		http://purl.obolibrary.org/obo/UBERON_0015148		pheno_slim
UBERON:0015147	biolink:AnatomicalEntity	pinna hair	A strand of hair that is part of a pinna.		hp.json	ear hair	http://purl.obolibrary.org/obo/UBERON_0015147		pheno_slim
HP:0003236	biolink:PhenotypicFeature	Elevated circulating creatine kinase concentration	An elevation of the level of the enzyme creatine kinase (also known as creatine phosphokinase (CK; EC 2.7.3.2) in the blood. CK levels can be elevated in a number of clinical disorders such as myocardial infarction, rhabdomyolysis, and muscular dystrophy.	UMLS:C0151576|UMLS:C0241005	hp.json	Increased serum creatine phosphokinase|Elevated circulating creatine phosphokinase|Elevated creatine kinase|Increased serum creatine kinase|High serum creatine kinase|Elevated serum CPK|Increased CPK|Elevated serum creatine phosphokinase|Increased creatine phosphokinase|Elevated blood creatine phosphokinase|Increased serum CK|Elevated serum creatine kinase|Increased creatine kinase	http://purl.obolibrary.org/obo/HP_0003236		
HP:0030866	biolink:PhenotypicFeature	Large knee	Abnormally increased size of the knee joint.	UMLS:C4280736	hp.json		http://purl.obolibrary.org/obo/HP_0030866		
HP:0005899	biolink:PhenotypicFeature	obsolete Metaphyseal dysostosis			hp.json		http://purl.obolibrary.org/obo/HP_0005899		
HP:0030867	biolink:PhenotypicFeature	Vertical orbital dystopia	The orbits do not lie on the same horizontal plane, that is, one eye is lower than the other.	UMLS:C0431460|SNOMEDCT_US:253243008	hp.json	Eyes at different heights|Misaligned eyes|Unequal eye height	http://purl.obolibrary.org/obo/HP_0030867		
HP:0003235	biolink:PhenotypicFeature	Hypermethioninemia	An increased concentration of methionine in the blood.	UMLS:C0268621|MSH:C564683|SNOMEDCT_US:57835009|SNOMEDCT_US:124283007|SNOMEDCT_US:43123004	hp.json	Methioninemia|Increased methionine in blood	http://purl.obolibrary.org/obo/HP_0003235		
HP:0030868	biolink:PhenotypicFeature	Monorchism	Having only one testis in the scrotum.	SNOMEDCT_US:87310001|UMLS:C0266429	hp.json	Monorchidism	http://purl.obolibrary.org/obo/HP_0030868		
HP:0003234	biolink:PhenotypicFeature	Decreased plasma carnitine	A decreased concentration of carnitine in the blood.	SNOMEDCT_US:421784001|UMLS:C1142132	hp.json	Carnitine deficiency|Decreased plasma carnitine	http://purl.obolibrary.org/obo/HP_0003234		
HP:0003233	biolink:PhenotypicFeature	Decreased HDL cholesterol concentration	An decreased concentration of high-density lipoprotein cholesterol in the blood.	SNOMEDCT_US:190785000|UMLS:C0151691|MSH:D052456|UMLS:C0473527	hp.json	Decreased circulating high-density lipoprotein levels|Decreased circulating high-density lipoprotein cholesterol|Low HDL-cholesterol|Decreased HDL cholesterol|Hypoalphalipoproteinemia	http://purl.obolibrary.org/obo/HP_0003233		
HP:0030869	biolink:PhenotypicFeature	Anorchism	An abnormality of XY sexual development characterized by the absence of both testes at birth.	SNOMEDCT_US:371015003|UMLS:C1261504|MSH:C537770	hp.json		http://purl.obolibrary.org/obo/HP_0030869		
HP:0030862	biolink:PhenotypicFeature	Elevated CSF amyloid level	Increased concentration of amyloid in the cerebrospinal fluid (CSF).	UMLS:C4280738	hp.json		http://purl.obolibrary.org/obo/HP_0030862		
HP:0005895	biolink:PhenotypicFeature	Radial deviation of thumb terminal phalanx		UMLS:C4025111	hp.json		http://purl.obolibrary.org/obo/HP_0005895		
HP:0003239	biolink:PhenotypicFeature	Phosphoethanolaminuria	An increased level of phosphoethanolamine (synonym: O-phosphoethanolamine) in the urine.	SNOMEDCT_US:55236002|MSH:C562646|UMLS:C0268412	hp.json	Increased level of O-phosphoethanolamine in urine|Increased urine O-phosphoethanolamine level|High urine phosphoethanolamine levels	http://purl.obolibrary.org/obo/HP_0003239		
HP:0030863	biolink:PhenotypicFeature	Nasal flaring	Widening of the nostrils upon inhalation as a manifestation of respiratory distress.	SNOMEDCT_US:21558008|SNOMEDCT_US:248568003|UMLS:C0277873	hp.json		http://purl.obolibrary.org/obo/HP_0030863		
HP:0005897	biolink:PhenotypicFeature	Severe generalized osteoporosis	Severe degree of osteoporosis.	UMLS:C1859443	hp.json	Severe generalised osteoporosis|Severe, generalised osteoporosis|Severe, generalized osteoporosis	http://purl.obolibrary.org/obo/HP_0005897		
HP:0003238	biolink:PhenotypicFeature	Hyperpepsinogenemia I		UMLS:C4025638	hp.json		http://purl.obolibrary.org/obo/HP_0003238		
NCBITaxon:9721	biolink:OrganismalEntity	Cetacea			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_9721		
HP:0030864	biolink:PhenotypicFeature	Intercostal retractions	A pulling inward of the soft tissues between the ribs upon inhalation. This is a sign of increased use of the chest muscles for breathing and is a manifestation of respiratory distress.	SNOMEDCT_US:6442005|UMLS:C0425470	hp.json	Chest retractions	http://purl.obolibrary.org/obo/HP_0030864		
HP:0030865	biolink:PhenotypicFeature	Large elbow	Abnormal increased size of the elbow joint.	UMLS:C4280737	hp.json	Prominent elbow	http://purl.obolibrary.org/obo/HP_0030865		
HP:0003237	biolink:PhenotypicFeature	Increased circulating IgG level	An abnormally increased level of immunoglobulin G in blood.	UMLS:C1858977	hp.json	Increased levels of IgG|Increased total IgG in blood|Increased IgG level	http://purl.obolibrary.org/obo/HP_0003237		
NCBITaxon:9722	biolink:OrganismalEntity	Odontoceti			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_9722		
HP:0005891	biolink:PhenotypicFeature	Progressive forearm bowing	Progressive bending or abnormal curvature of the forearm skeleton.	UMLS:C3152020	hp.json	Progressive forearm curvature	http://purl.obolibrary.org/obo/HP_0005891		
HP:0005892	biolink:PhenotypicFeature	Proximal tibial and fibular fusion		UMLS:C4025113	hp.json	Fusion of innermost shinbone and calf bone	http://purl.obolibrary.org/obo/HP_0005892		
HP:0005894	biolink:PhenotypicFeature	Double first metacarpals	Duplication of the metacarpal I bones.	UMLS:C4025112	hp.json	Double 1st long bones of hand	http://purl.obolibrary.org/obo/HP_0005894		
HP:0003232	biolink:PhenotypicFeature	Mitochondrial malic enzyme reduced		UMLS:C1856697	hp.json	Decreased mitochondrial malic enzyme	http://purl.obolibrary.org/obo/HP_0003232		
HP:0003231	biolink:PhenotypicFeature	Hypertyrosinemia	An increased concentration of tyrosine in the blood.	UMLS:C1879362|SNOMEDCT_US:56595005	hp.json	Increased tyrosine in blood|Tyrosinemia	http://purl.obolibrary.org/obo/HP_0003231		
HP:0005890	biolink:PhenotypicFeature	Hyperostosis cranialis interna	Bony overgrowth of the internal (endosteal) surface of the calvaria and the base of skull.	UMLS:C1840404|MSH:C564168|UMLS:C4280469|UMLS:C4280468|UMLS:C4280472|UMLS:C4280471|UMLS:C4280470	hp.json	Increased ossification of the internal surface of the cranial bones|Overgrowth of the inner surface of the skull bones|Hyperostosis of the internal surface of the cranial bones|Enlargement of the inner surface of the skull bones|Excessive growth of inner surface of the skull bones|Overgrowth of the inside of the skull|Hyperostosis of the internal surface of the cranial bone|Thick internal surface of the cranial bones|Thick inner surface of the skull bones|Hypertrophy of the internal surface of the cranial bones	http://purl.obolibrary.org/obo/HP_0005890		
UBERON:0015130	biolink:AnatomicalEntity	connective tissue of prostate gland	A portion of connective tissue that is part of a prostate gland.	FMA:74165	hp.json	connective tissue of prostate	http://purl.obolibrary.org/obo/UBERON_0015130		
HP:0030870	biolink:PhenotypicFeature	Abnormality of spinal facet joint	An anomaly of the small joints located between and behind adjacent vertebrae.	UMLS:C4280735	hp.json	Abnormality of apophyseal joint|Abnormality of zygapophysial joint|Abnormality of zygapophyseal joint|Abnormality of Z-joint	http://purl.obolibrary.org/obo/HP_0030870		
HP:0003209	biolink:PhenotypicFeature	Decreased pyruvate carboxylase activity	A decreased rate of pyruvate carboxylase activity.	UMLS:C4025641	hp.json		http://purl.obolibrary.org/obo/HP_0003209		
HP:0030871	biolink:PhenotypicFeature	Facet joint arthrosis	Osteoarthritis of facet joints in the spine. Degeneration of cartilage in the facet joints results in bone rubbing on bone and reactive new bone formation visible on X-ray.	UMLS:C4280734	hp.json	Facet arthritis	http://purl.obolibrary.org/obo/HP_0030871		
HP:0003208	biolink:PhenotypicFeature	Fingerprint intracellular accumulation of autofluorescent lipopigment storage material	An intracellular accumulation of autofluorescent lipopigment storage material in a trabecular or fingerprint-like pattern.	UMLS:C1836851	hp.json	Fingerprint profiles ultrastructurally in cells|Fingerprint profiles ultrastructurally	http://purl.obolibrary.org/obo/HP_0003208		
HP:0030872	biolink:PhenotypicFeature	Abnormal cardiac ventricular function	An abnormality of the cardiac ventricular function.	UMLS:C4280733	hp.json		http://purl.obolibrary.org/obo/HP_0030872		
HP:0030877	biolink:PhenotypicFeature	Reduced FEV1/FVC ratio	Abnormally low FEV1/FVC (FEV1 - forced expiratory volume in 1 second; FVC forced vital capacity).	UMLS:C4280729	hp.json	Obstructive deficit on pulmonary function test|Obstructive deficit on pulmonary function testing	http://purl.obolibrary.org/obo/HP_0030877		
HP:0005866	biolink:PhenotypicFeature	Opposable triphalangeal thumb	A form of triphalangeal thumb that can be placed opposite the fingers of the same hand.	UMLS:C4025122	hp.json		http://purl.obolibrary.org/obo/HP_0005866		
HP:0003203	biolink:PhenotypicFeature	Impaired oxidative burst	In the NBT test, neutrophils change the colorless compound NBT into a compound with a deep blue color. If this test is negative (i.e., no blue color is produced), then this indicates a defect in superoxide-generating NADPH oxidase activity with inability to efficiently kill phagocytized bacteria.	UMLS:C4280805	hp.json	Negative nitroblue tetrazolium reduction test|Negative NBT reduction test	http://purl.obolibrary.org/obo/HP_0003203		
HP:0030878	biolink:PhenotypicFeature	Abnormality on pulmonary function testing	Any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography.	UMLS:C4280728	hp.json	Abnormal spirometry test|Abnormal pulmonary function test	http://purl.obolibrary.org/obo/HP_0030878		
HP:0005867	biolink:PhenotypicFeature	4-5 metacarpal synostosis		UMLS:C1859768	hp.json	Fused 4th-5th long bones of hand|Synostosis of the fourth and fifth metacarpal bones|Fused 4th-5th metacarpals|Ring finger and little finger metacarpal synostosis|Fused fourth and fifth metacarpals	http://purl.obolibrary.org/obo/HP_0005867		
HP:0003202	biolink:PhenotypicFeature	Skeletal muscle atrophy	The presence of skeletal muscular atrophy (which is also known as amyotrophy).	MSH:D009133|SNOMEDCT_US:74035001|UMLS:C0234958|UMLS:C0270948|UMLS:C1843479|UMLS:C0541794	hp.json	Muscle atrophy, neurogenic|Neurogenic muscle atrophy|Amyotrophy|Muscle degeneration|Muscle atrophy|Neurogenic muscular atrophy|Muscular atrophy|Neurogenic muscle atrophy, especially in the lower limbs|Amyotrophy involving the extremities|Muscle wasting|Muscle hypotrophy	http://purl.obolibrary.org/obo/HP_0003202		
HP:0005868	biolink:PhenotypicFeature	Metaphyseal enchondromatosis	An enchondroma is a benign growth of cartilage that develops within the medullary cavity of bone. Enchondromatosis refers to the presence of multiple enchondromas, and this term refers to the presence of multiple enchondromas within the medulla of metaphyseal bone. Radiographically an enchondroma presents a an oval, linear, or pyramidal osteolytic (radiolucent) lesion with well defined margins.	UMLS:C4025121	hp.json		http://purl.obolibrary.org/obo/HP_0005868		
HP:0003201	biolink:PhenotypicFeature	Rhabdomyolysis	Breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream.	MSH:D012206|SNOMEDCT_US:240131006|SNOMEDCT_US:89010004|UMLS:C0035410	hp.json	Breakdown of skeletal muscle	http://purl.obolibrary.org/obo/HP_0003201		
HP:0030879	biolink:PhenotypicFeature	Interlobular septal thickening	Presence of thickening of the interlobular septa of the lungs as seen on a CT scan.	UMLS:C4280727	hp.json	Septal lines (pulmonary CT finding)|Interlobular septal thickening on pulmonary HRCT|Short lines (pumonary CT finding)|Interlobular lines (pulmonary CT finding)|Peripheral lines (pulmonary CT finding)|Septal thickening (pulmonary CT finding)	http://purl.obolibrary.org/obo/HP_0030879		
HP:0003200	biolink:PhenotypicFeature	Ragged-red muscle fibers	An abnormal appearance of muscle fibers observed on muscle biopsy. Ragged red fibers can be visualized with Gomori trichrome staining as irregular and intensely red subsarcolemmal zones, whereas the normal myofibrils are green. The margins of affect fibers appear red and ragged. The ragged-red is due to the accumulation of abnormal mitochondria below the plasma membrane of the muscle fiber, leading to the appearance of a red rim and speckled sarcoplasm.	UMLS:C3275417	hp.json	Ragged red muscle fibers|Ragged-red fibers|Ragged-red muscle fibres|Mitochondrial proliferation in muscle tissue|Ragged-red fibres|Ragged red muscle fibres	http://purl.obolibrary.org/obo/HP_0003200		
HP:0030873	biolink:PhenotypicFeature	Anti-centromere antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against the centromeres or centromere components.	UMLS:C4280732	hp.json	ACA positivity|Anticentromere antibody positivity	http://purl.obolibrary.org/obo/HP_0030873		
HP:0003207	biolink:PhenotypicFeature	Arterial calcification	Pathological deposition of calcium salts in one or more arteries.	UMLS:C1168153	hp.json		http://purl.obolibrary.org/obo/HP_0003207		
GO:0080090	biolink:BiologicalProcess	regulation of primary metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.		hp.json		http://purl.obolibrary.org/obo/GO_0080090		
HP:0030874	biolink:PhenotypicFeature	Oxygen desaturation on exertion	Oxygen saturation less than 95% on exertion or arterial partial pressure of oxygen falling by more than 1kPa.	UMLS:C4280731	hp.json	O2 desaturation on exertion	http://purl.obolibrary.org/obo/HP_0030874		
HP:0005863	biolink:PhenotypicFeature	Type E brachydactyly	In type E brachydactyly, shortening of the fingers is mainly in the metacarpals and metatarsals.	MSH:C566194|UMLS:C1862102	hp.json		http://purl.obolibrary.org/obo/HP_0005863		
HP:0003206	biolink:PhenotypicFeature	Decreased activity of NADPH oxidase		UMLS:C1844394	hp.json		http://purl.obolibrary.org/obo/HP_0003206		
HP:0003205	biolink:PhenotypicFeature	Curvilinear intracellular accumulation of autofluorescent lipopigment storage material	An intracellular accumulation of autofluorescent lipopigment storage material in a curved pattern.	UMLS:C1836852	hp.json	Curvilinear profiles ultrastructurally|Intracellular curvilinear profiles on ultrastructural analysis|Curvilinear profiles ultrastructurally in cells	http://purl.obolibrary.org/obo/HP_0003205		
HP:0030875	biolink:PhenotypicFeature	Abnormality of pulmonary circulation	A functional anomaly of that portion of the cardiosvascular system that carries deoxygenated blood from the heart to the lungs and returns oxygenated blood back to the heart.	UMLS:C4280730	hp.json	Abnormality of respiratory circulation|Abnormal pulmonary circulation	http://purl.obolibrary.org/obo/HP_0030875		
HP:0005864	biolink:PhenotypicFeature	Pseudoarthrosis	A pathologic entity characterized by a developmental defect in a long bone leading to bending and pathologic fracture, with inability to form a normal bony callus with subsequent fibrous nonunion, leading to the pseudarthrosis (or "false joint").	MSH:D011542|UMLS:C0033785|SNOMEDCT_US:410818009|SNOMEDCT_US:31511007	hp.json	Pseudoarthroses	http://purl.obolibrary.org/obo/HP_0005864		
HP:0030876	biolink:PhenotypicFeature	Increased pulmonary capillary wedge pressure	Pulmonary capillary wedge pressure (PCWP) above 15mmHg.	UMLS:C0520850|SNOMEDCT_US:30261008	hp.json	Increased pulmonary artery occlusion pressure|Increased pulmonary arterial wedge pressure	http://purl.obolibrary.org/obo/HP_0030876		
HP:0003204	biolink:PhenotypicFeature	Intracellular accumulation of autofluorescent lipopigment storage material	The intracellular accumulation of autofluorescent storage material.	UMLS:C4025642	hp.json		http://purl.obolibrary.org/obo/HP_0003204		
UBERON:0015120	biolink:AnatomicalEntity	right outer canthus	An outer canthus that is in_the_right_side_of a head.	FMA:59317	hp.json	right lateral canthus|right lateral palpebral commissure|right angle of eye|lateral canthus of right eye|lateral angle of right eye	http://purl.obolibrary.org/obo/UBERON_0015120		
HP:0040203	biolink:PhenotypicFeature	Abnormal CSF neopterin concentration	Abnormal concentration of neopterin in the cerebrospinal fluid (CSF).	UMLS:C4073151	hp.json	Abnormal CSF neopterin level	http://purl.obolibrary.org/obo/HP_0040203		
HP:0040204	biolink:PhenotypicFeature	Elevated CSF neopterin level	Increased concentration of neopterin in the cerebrospinal fluid (CSF).	UMLS:C4073152	hp.json		http://purl.obolibrary.org/obo/HP_0040204		
UBERON:0015122	biolink:AnatomicalEntity	anatomical line between outer canthi	An anatomical line of the face that connects the two outer (lateral) canthi of the eye. The length of this line is known as the outer canthal distance.		hp.json	inter outer canthal line|inter lateral canthal line	http://purl.obolibrary.org/obo/UBERON_0015122		
HP:0040201	biolink:PhenotypicFeature	Simultanapraxia	A subset of motor impersistence, defined as the inability to perform more than two of the simple voluntary acts simultaneously, such as closing the eyes and protruding the tongue.	UMLS:C4073149	hp.json		http://purl.obolibrary.org/obo/HP_0040201		
UBERON:0015121	biolink:AnatomicalEntity	left outer canthus	An outer canthus that is in_the_left_side_of a head.	FMA:59318	hp.json	left lateral palpebral commissure|left angle of eye|left lateral canthus|lateral angle of left eye|lateral canthus of left eye	http://purl.obolibrary.org/obo/UBERON_0015121		
HP:0040202	biolink:PhenotypicFeature	Abnormal consumption behavior		UMLS:C4073150	hp.json	Abnormal consumption behaviour	http://purl.obolibrary.org/obo/HP_0040202		
HP:0040207	biolink:PhenotypicFeature	Abnormal CSF biopterin concentration	Abnormal concentration of biopterin in the cerebrospinal fluid (CSF).	UMLS:C4073155	hp.json	Abnormal cerebrospinal fluid biopterin level|Abnormal CSF biopterin level	http://purl.obolibrary.org/obo/HP_0040207		
UBERON:1100000	biolink:AnatomicalEntity	digestive tract junction	An anatomical junction between two parts of the digestive tract.		hp.json		http://purl.obolibrary.org/obo/UBERON_1100000		
HP:0040208	biolink:PhenotypicFeature	Elevated CSF biopterin level	Increased concentration of biopterin in the cerebrospinal fluid (CSF).	UMLS:C4073156	hp.json		http://purl.obolibrary.org/obo/HP_0040208		
CHEBI:83925	biolink:ChemicalSubstance	non-proteinogenic alpha-amino acid	Any  alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.		hp.json	non-proteinogenic alpha-amino-acids|non-proteinogenic alpha-amino acids|non-proteinogenic alpha-amino-acid	http://purl.obolibrary.org/obo/CHEBI_83925		3_STAR
HP:0040205	biolink:PhenotypicFeature	Decreased CSF neopterin level	Decreased concentration of neopterin in the cerebrospinal fluid (CSF).	UMLS:C4073153	hp.json		http://purl.obolibrary.org/obo/HP_0040205		
HP:0040206	biolink:PhenotypicFeature	Abnormal circulating neopterin concentration	Any deviation from the normal concentration of neopterin in the blood circulation.	UMLS:C4073154	hp.json		http://purl.obolibrary.org/obo/HP_0040206		
UBERON:0015128	biolink:AnatomicalEntity	subepicardial layer of epicardium		FMA:83105	hp.json	perimysial connective tissue of subepicardium|subepicardial connective tissue	http://purl.obolibrary.org/obo/UBERON_0015128		
HP:0030880	biolink:PhenotypicFeature	Raynaud phenomenon		UMLS:C0034735|MSH:D011928|SNOMEDCT_US:266261006	hp.json	Raynaud disease|Raynaud's phenomenon	http://purl.obolibrary.org/obo/HP_0030880		
HP:0030881	biolink:PhenotypicFeature	Shoulder impingement	Trapping and compression of the rotator cuff tendons during shoulder movements.	UMLS:C1655733	hp.json		http://purl.obolibrary.org/obo/HP_0030881		
HP:0030882	biolink:PhenotypicFeature	Coronary artery aneurysm	Enlargement of the diameter (cross-section) of a coronary artery as defined by a focal dilation of a segment at least 1.5 times larger than the reference vessel.	UMLS:C4255100|Fyler:3129	hp.json	Coronary artery ectasia|Coronary artery dilatation|Coronary arterial dilatation	http://purl.obolibrary.org/obo/HP_0030882		
HP:0040209	biolink:PhenotypicFeature	Decreased CSF biopterin level	Decreased concentration of biopterin in the cerebrospinal fluid (CSF).	UMLS:C4073157	hp.json	Decreased cerebrospinal fluid biopterin level	http://purl.obolibrary.org/obo/HP_0040209		
HP:0030883	biolink:PhenotypicFeature	Femoroacetabular impingement	Femoroacetabular impingement (FAI) results from one or more bony abnormalities that lead to abnormal contact between the acetabulum and the femoral head or neck. The femoral abnormality is proposed to cause compression and shear stresses in the region between the labrum and cartilage, anterosuperiorly. These stresses cause a separation between the labrum and cartilage as the labrum is pushed outwards and the cartilage is pushed centrally. This eventually leads to articular degeneration and eventually global hip osteoarthritis.	SNOMEDCT_US:432473000|UMLS:C2936290|MSH:D057925	hp.json	Femoral acetabular impingement	http://purl.obolibrary.org/obo/HP_0030883		
UBERON:0015129	biolink:AnatomicalEntity	epicardial fat	Visceral intrapericardial fat contiguous with the myocardial surface.	FMA:9871|SCTID:42267001	hp.json	epicardial adipose tissue|pericardial adipose tissue	http://purl.obolibrary.org/obo/UBERON_0015129		
HP:0003219	biolink:PhenotypicFeature	Ethylmalonic aciduria	An increased concentration of ethylmalonic acid in the urine.	UMLS:C1865353	hp.json		http://purl.obolibrary.org/obo/HP_0003219		
PR:P11413	biolink:Protein	glucose-6-phosphate 1-dehydrogenase (human)	A glucose-6-phosphate 1-dehydrogenase that is encoded in the genome of human.	UniProtKB:P11413	hp.json	G6PD|hG6PD	http://purl.obolibrary.org/obo/PR_P11413		
HP:0003214	biolink:PhenotypicFeature	Prolonged G2 phase of cell cycle		UMLS:C4025639	hp.json		http://purl.obolibrary.org/obo/HP_0003214		
HP:0030888	biolink:PhenotypicFeature	C3 nephritic factor positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against C3 convertase (C3bBb).		hp.json		http://purl.obolibrary.org/obo/HP_0030888		
HP:0005877	biolink:PhenotypicFeature	Multiple small vertebral fractures		UMLS:C4025119	hp.json		http://purl.obolibrary.org/obo/HP_0005877		
HP:0030889	biolink:PhenotypicFeature	Congenital shortened small intestine	Substantially shortened length of the small intestine as a result of a developmental defect.		hp.json	Short bowel	http://purl.obolibrary.org/obo/HP_0030889		
HP:0005878	biolink:PhenotypicFeature	Enlarged sagittal diameter of the cervical canal		UMLS:C4025118	hp.json		http://purl.obolibrary.org/obo/HP_0005878		
HP:0003213	biolink:PhenotypicFeature	Deficient excision of UV-induced pyrimidine dimers in DNA		UMLS:C4025640	hp.json		http://purl.obolibrary.org/obo/HP_0003213		
HP:0005879	biolink:PhenotypicFeature	Congenital finger flexion contractures	Multiple bent (flexed) finger joints that cannot be straightened actively or passively.	UMLS:C1393871	hp.json	Congenital finger contractures	http://purl.obolibrary.org/obo/HP_0005879		
HP:0003212	biolink:PhenotypicFeature	Increased circulating IgE level	An abnormally increased overall level of immunoglobulin E in blood.	UMLS:C0236175	hp.json	High immunoglobulin E|Elevated immunoglobulin E|Elevated serum IgE	http://purl.obolibrary.org/obo/HP_0003212		
HP:0003218	biolink:PhenotypicFeature	Oroticaciduria	An increased concentration of orotic acid in the urine.	SNOMEDCT_US:124277009|SNOMEDCT_US:47641009|UMLS:C0268128	hp.json	High urine orotic acid levels|Increased urinary orotic acid concentration|Orotic aciduria	http://purl.obolibrary.org/obo/HP_0003218		
HP:0005873	biolink:PhenotypicFeature	Polysyndactyly of hallux	Combined syndactyly and polydactyly of the great toe.	UMLS:C4021618	hp.json	Polysyndactyly of great toe|Polysyndactyly of big toe	http://purl.obolibrary.org/obo/HP_0005873		
HP:0030884	biolink:PhenotypicFeature	Gastrojejunal tube feeding in infancy	Feeding problem necessitating gastrojejunal tube feeding.	UMLS:C4280681	hp.json	Gastro-jejunal tube feeding in infancy	http://purl.obolibrary.org/obo/HP_0030884		
HP:0003217	biolink:PhenotypicFeature	Hyperglutaminemia	An increased concentration of glutamine in the blood.	UMLS:C1839533	hp.json	High plasma glutamine	http://purl.obolibrary.org/obo/HP_0003217		
HP:0030885	biolink:PhenotypicFeature	Recurrent parasitic infections	Increased susceptibility to parasitic infections, as manifested by recurrent episodes of parasitic infection.	UMLS:C4280726	hp.json		http://purl.obolibrary.org/obo/HP_0030885		
HP:0005875	biolink:PhenotypicFeature	Increased dermatoglyphic whorls		UMLS:C4025120	hp.json		http://purl.obolibrary.org/obo/HP_0005875		
HP:0030886	biolink:PhenotypicFeature	Abnormal lymphocyte apoptosis	A anomaly in the rate of programmed cell death (apoptosis) in lymphocytes.	UMLS:C4280725	hp.json		http://purl.obolibrary.org/obo/HP_0030886		
HP:0003216	biolink:PhenotypicFeature	Generalized amyloid deposition	A diffuse form of amyloidosis.	UMLS:C1862968	hp.json	Generalised amyloid deposition	http://purl.obolibrary.org/obo/HP_0003216		
MPATH:212	biolink:NamedThing	inflammation	A tissue reaction to an internal or external injury.		hp.json		http://purl.obolibrary.org/obo/MPATH_212		
HP:0003215	biolink:PhenotypicFeature	Dicarboxylic aciduria	An increased concentration of dicarboxylic acid in the urine.	UMLS:C1856432	hp.json		http://purl.obolibrary.org/obo/HP_0003215		
HP:0005876	biolink:PhenotypicFeature	Progressive flexion contractures	Progressively worsening joint contractures.	UMLS:C3279322	hp.json	Joint contractures, progressive	http://purl.obolibrary.org/obo/HP_0005876		
HP:0030887	biolink:PhenotypicFeature	Increased lymphocyte apoptosis	A elevation in the rate of apoptosis in lymphocytes.	UMLS:C4280724	hp.json		http://purl.obolibrary.org/obo/HP_0030887		
HP:0005871	biolink:PhenotypicFeature	Metaphyseal chondrodysplasia	An abnormality of skeletal development characterized by a disturbance of the metaphysis and its histological structure with relatively normal epiphyses and vertebrae.	UMLS:C0265290|SNOMEDCT_US:28681006	hp.json		http://purl.obolibrary.org/obo/HP_0005871		
HP:0005872	biolink:PhenotypicFeature	Brachytelomesophalangy	Disproportionately short middle and distal phalanges compared to the hand/foot.	UMLS:C1847408	hp.json	Progressive brachydactyly of middle and distal phalanges|Short middle and distal phalanges of digits ii through v	http://purl.obolibrary.org/obo/HP_0005872		
HP:0003210	biolink:PhenotypicFeature	Decreased methylmalonyl-CoA mutase activity	An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of methylmalonyl-CoA mutase activity.	UMLS:C1848579	hp.json	Decreased methylmalonyl CoA mutase activity	http://purl.obolibrary.org/obo/HP_0003210		
MPATH:218	biolink:NamedThing	neoplasm	A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant.		hp.json		http://purl.obolibrary.org/obo/MPATH_218		
HP:0040200	biolink:PhenotypicFeature	Motor impersistence	The inability to maintain postures or positions (such as keeping eyes closed, protruding the tongue, maintaining conjugate gaze steadily in a fixed direction, or making a prolonged 'ah' sound) without repeated prompts.	UMLS:C4073148	hp.json	Negative chorea	http://purl.obolibrary.org/obo/HP_0040200		
NCBITaxon:9747	biolink:OrganismalEntity	Monodontidae			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_9747		
HP:0030811	biolink:PhenotypicFeature	Tongue pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the tongue.	SNOMEDCT_US:30731004|MSH:D005926|UMLS:C0017672	hp.json	Painful tongue	http://purl.obolibrary.org/obo/HP_0030811		
HP:0003269	biolink:PhenotypicFeature	Sudanophilic leukodystrophy		SNOMEDCT_US:64855000|MSH:D020371|UMLS:C0205711	hp.json		http://purl.obolibrary.org/obo/HP_0003269		
HP:0003268	biolink:PhenotypicFeature	Argininuria	A increased concentration of arginine in the urine.	UMLS:C4025635	hp.json	High urine arginine levels	http://purl.obolibrary.org/obo/HP_0003268		
HP:0030812	biolink:PhenotypicFeature	Enlarged tonsils	Increase in size of the tonsils, small collections of lymphoid tissue facing into the aerodigestive tract on either side of the back part of the throat.	UMLS:C0272386|SNOMEDCT_US:46689006	hp.json	tonsils large/hypertrophy|Enlargment of tonsils|Tonsillar hypertrophy	http://purl.obolibrary.org/obo/HP_0030812		
HP:0030813	biolink:PhenotypicFeature	Absent tonsils	Lack of observable tonsillar tissue.	SNOMEDCT_US:300277007|UMLS:C0576999|SNOMEDCT_US:249393008	hp.json	Hypoplastic tonsils|Tonsillar hypoplasia	http://purl.obolibrary.org/obo/HP_0030813		
HP:0003267	biolink:PhenotypicFeature	Reduced orotidine 5-prime phosphate decarboxylase level	An abnormal decrease in orotidine 5'-phosphate decarboxylase level.	UMLS:C4020845|UMLS:C4025636	hp.json	Orotidine-5-prime-phosphate decarboxylase defect	http://purl.obolibrary.org/obo/HP_0003267		
HP:0030814	biolink:PhenotypicFeature	Orange discolored tonsils	A phenomenon of orange colored oral tonsils. This feature is characteristic of Tangier disease and illustrated will by Figure 1 of PMID:19470903.	UMLS:C4280753	hp.json	Orange colored tonsils|Orange tonsils|Orange coloured tonsils|Tonsils with orange deposits|Orange discoloured tonsils	http://purl.obolibrary.org/obo/HP_0030814		
MPATH:201	biolink:NamedThing	vasculitis	Inflammation of a blood vessel.		hp.json	arteritis|angiitis|lymphangiitis|phlebitis	http://purl.obolibrary.org/obo/MPATH_201		
HP:0030810	biolink:PhenotypicFeature	Abnormal tongue physiology	Any functional anomaly of the tongue.	UMLS:C4280754	hp.json		http://purl.obolibrary.org/obo/HP_0030810		
HP:0030819	biolink:PhenotypicFeature	Ski jump nail	Nails that slope upward at the free edge.	UMLS:C4280751	hp.json	Upslanting nail|Upward angulation of nail	http://purl.obolibrary.org/obo/HP_0030819		
HP:0003261	biolink:PhenotypicFeature	Increased circulating IgA level	An abnormally increased level of immunoglobulin A in blood.	UMLS:C0239984	hp.json	IgA hypergammaglobulinemia|Elevated serum IgA|Elevated IgA|Increased serum IgA|Increased levels of IgA	http://purl.obolibrary.org/obo/HP_0003261		
CHEBI:46912	biolink:ChemicalSubstance	ornithinium(1+)			hp.json	ornithinium|2,5-diammoniopentanoate|ornithine monocation|ornithinium(1+)	http://purl.obolibrary.org/obo/CHEBI_46912		3_STAR
CHEBI:46913	biolink:ChemicalSubstance	ornithinium(2+)			hp.json	ornithinediium|ornithine dication|1-carboxybutane-1,4-diaminium|ornithinium(2+)	http://purl.obolibrary.org/obo/CHEBI_46913		3_STAR
HP:0003260	biolink:PhenotypicFeature	Hydroxyprolinemia	An increased concentration of hydroxyproline in the blood.	UMLS:C0268531|MSH:C562669|SNOMEDCT_US:25739007	hp.json	High blood hydroxyproline levels	http://purl.obolibrary.org/obo/HP_0003260		
CHEBI:46915	biolink:ChemicalSubstance	sarcosinate	An alpha-amino-acid anion that is the conjugate base of sarcosine, arising from deprotonation of the carboxy group.	Gmelin:81987|Reaxys:3536300|Beilstein:3536300	hp.json	(methylamino)acetate|sarcosinate	http://purl.obolibrary.org/obo/CHEBI_46915		3_STAR
HP:0003265	biolink:PhenotypicFeature	Neonatal hyperbilirubinemia	A type of hyperbilirubinemia with neonatal onset.	MSH:D051556|UMLS:C0857007|SNOMEDCT_US:281610001	hp.json	Hyperbilirubinemia, neonatal|High blood bilirubin levels in neonate	http://purl.obolibrary.org/obo/HP_0003265		
HP:0030815	biolink:PhenotypicFeature	Lipoma of the tongue	A lipoma localized to the tongue. May present as a nontender, soft, spherical mass of the tongue.	UMLS:C0238467	hp.json	Tongue lipoma	http://purl.obolibrary.org/obo/HP_0030815		
HP:0003264	biolink:PhenotypicFeature	Deficiency of N-acetylglucosamine-1-phosphotransferase		MSH:D009081|UMLS:C0020725|SNOMEDCT_US:70199000	hp.json		http://purl.obolibrary.org/obo/HP_0003264		
HP:0030816	biolink:PhenotypicFeature	Gingival recession	The loss of gum tissue. The result is that gum tissue is recessed and its position on the tooth is lowered, exposing the roots of the teeth.	SNOMEDCT_US:4356008|UMLS:C0017572|MSH:D005889	hp.json	Gum recession|Receding gums	http://purl.obolibrary.org/obo/HP_0030816		
HP:0030817	biolink:PhenotypicFeature	Beaked nails	Severe nail curvature, causing the tip of the nail to point downwards with respect to the axis of the finger. Beaked nails are caused by resorption of the distal digit.	UMLS:C4280752	hp.json		http://purl.obolibrary.org/obo/HP_0030817		
HP:0003262	biolink:PhenotypicFeature	Smooth muscle antibody positivity	The presence in serum of antibodies against smooth muscle.	SNOMEDCT_US:310290006|UMLS:C0241185	hp.json	Smooth muscle antibody positive|Anti-smooth muscle antibody positivity	http://purl.obolibrary.org/obo/HP_0003262		
HP:0030818	biolink:PhenotypicFeature	Central nail canal	The presence of a depressed line ("canal") in the center of the nail.	UMLS:C0263526|SNOMEDCT_US:86393005|SNOMEDCT_US:238718006	hp.json	Median nail dystrophy	http://purl.obolibrary.org/obo/HP_0030818		
UBERON:0015181	biolink:AnatomicalEntity	neck of tooth	The slightly constricted part of a tooth, between the crown and the root.	NCIT:C32346|FMA:55627	hp.json	cervix of tooth|tooth neck|dental neck|collumn dentis|cervical zone of tooth|cervical margin of tooth|cervix dentis	http://purl.obolibrary.org/obo/UBERON_0015181		
HP:0030822	biolink:PhenotypicFeature	Hooded upper eyelid	Upper eyelid partly covered by skin when eyes are open.	UMLS:C4280749	hp.json		http://purl.obolibrary.org/obo/HP_0030822		
HP:0003279	biolink:PhenotypicFeature	Coxa magna	Widening of the femoral head and neck.	SNOMEDCT_US:296041000119103|MSH:D000070603|UMLS:C1860826	hp.json		http://purl.obolibrary.org/obo/HP_0003279		
HP:0030823	biolink:PhenotypicFeature	Scleral thickening	Increased dimension of the sclera in the anterior-posterior axis.	UMLS:C2674403	hp.json	Thick sclera	http://purl.obolibrary.org/obo/HP_0030823		
HP:0030824	biolink:PhenotypicFeature	Mizuo phenomenon	Change in the color of the fundus from red in the dark-adapted state to golden immediately or shortly after the onset of the light. The color of the fundus reflex in the light adapted state has also been described as golden-yellow, gray-white, and yellow-white. This reflex can appear either homogeneous or in streaks in the fundus. The retinal vessels appear to be protruding in contrast to the radiant background. Dark adaptation leads to disappearance of the unusual fundus coloration [Digital Journal of Ophthalmology 2008; Volume 14, Number 14].	UMLS:C4280748	hp.json	Mizuo-Nakamura phenomenon	http://purl.obolibrary.org/obo/HP_0030824		
HP:0003278	biolink:PhenotypicFeature	Square pelvis bone	An abnormally squared appearance of the bony pelvis, a normally rounded or basin-shaped structure.	UMLS:C1849953	hp.json	Square pelvis|Squared off pelvis|Square pelvis bone	http://purl.obolibrary.org/obo/HP_0003278		
HP:0030825	biolink:PhenotypicFeature	Absent foveal reflex	Lack of the foveal reflex, which normally occurs as a result of the reflection of light from the ophthalmoscope in the foveal pit upon examination. The foveal reflex is a bright pinpoint of light that is observed to move sideways or up and down in response to movement of the opthalmoscope.	SNOMEDCT_US:247144003|UMLS:C0423420	hp.json	Foveal reflex absent|Loss of foveal reflex	http://purl.obolibrary.org/obo/HP_0030825		
HP:0003277	biolink:PhenotypicFeature	Constricted iliac wing		UMLS:C1854785	hp.json	Constricted iliac wings	http://purl.obolibrary.org/obo/HP_0003277		
GO:0031090	biolink:CellularComponent	organelle membrane	A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.	NIF_Subcellular:sao830981606	hp.json	intracellular membrane	http://purl.obolibrary.org/obo/GO_0031090		
HP:0030820	biolink:PhenotypicFeature	Hooded eyelid	Eyelid partly covered by skin when eyes are open.	UMLS:C3277348	hp.json		http://purl.obolibrary.org/obo/HP_0030820		
HP:0030821	biolink:PhenotypicFeature	Hooded lower eyelid	Lower eyelid partly covered by skin when eyes are open.	UMLS:C4280750	hp.json		http://purl.obolibrary.org/obo/HP_0030821		
HP:0003272	biolink:PhenotypicFeature	Abnormal hip bone morphology	An abnormality of the hip bone.	UMLS:C4021735	hp.json	Abnormality of the hip bone|Abnormality of the hips	http://purl.obolibrary.org/obo/HP_0003272		
HP:0003271	biolink:PhenotypicFeature	Visceromegaly	Abnormal increased size of the viscera of the abdomen.	SNOMEDCT_US:28543008|UMLS:C0042782	hp.json		http://purl.obolibrary.org/obo/HP_0003271		
UBERON:0015180	biolink:AnatomicalEntity	neck of talus	The neck of talus is directed forward and medialward, and comprises the constricted portion of the bone between the body and the oval head. Its upper and medial surfaces are rough, for the attachment of ligaments; its lateral surface is concave and is continuous below with the deep groove for the interosseous talocalcaneal ligament.	FMA:33636	hp.json	collum tali|talus neck|talar neck	http://purl.obolibrary.org/obo/UBERON_0015180		pheno_slim
HP:0003270	biolink:PhenotypicFeature	Abdominal distention	Distention of the abdomen.	SNOMEDCT_US:41931001|UMLS:C0000731|SNOMEDCT_US:60728008	hp.json	Abdominal swelling|Abdominal distension|Bloating|Abdominal bloating|Distended abdomen|Belly bloating	http://purl.obolibrary.org/obo/HP_0003270		hposlim_core
CHEBI:46904	biolink:ChemicalSubstance	oxalate(1-)	A dicarboxylic acid monoanion that is the conjugate base of oxalic acid.	Gmelin:49515|Beilstein:3601755	hp.json	hydrogen ethanedioate|Hox|hydrogen oxalate|carboxyformate	http://purl.obolibrary.org/obo/CHEBI_46904		3_STAR
HP:0030826	biolink:PhenotypicFeature	Eyelid fasciculation	Tiny, repetitive muscle contractions in the eyelids, causing the appearance of twitching.	UMLS:C4280682	hp.json	Muscle twitches in eye lid|Eyelid fluttering|Twitching around eyes|Muscle twitches in eyelid|Fasciculation of the eyelid	http://purl.obolibrary.org/obo/HP_0030826		
HP:0003276	biolink:PhenotypicFeature	Pelvic bone exostoses	A benign growth the projects outward from the bone surface of the pelvis. Exostoses are capped by cartilage, and arise from a bone that develops from cartilage.	UMLS:C1844689	hp.json	Pelvic exostoses	http://purl.obolibrary.org/obo/HP_0003276		
GO:0031099	biolink:BiologicalProcess	regeneration	The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).	Wikipedia:Regeneration_(biology)	hp.json		http://purl.obolibrary.org/obo/GO_0031099		
HP:0003275	biolink:PhenotypicFeature	Narrow pelvis bone	Reduced side to side width of the pelvis.	UMLS:C1848103	hp.json	Narrow pelvis|Narrow pelvis bone	http://purl.obolibrary.org/obo/HP_0003275		hposlim_core
HP:0003274	biolink:PhenotypicFeature	Hypoplastic acetabulae	Underdeveloped acetabulae.	UMLS:C1846442	hp.json	Hypoplastic acetabula|Acetabular hypoplasia	http://purl.obolibrary.org/obo/HP_0003274		hposlim_core
HP:0030828	biolink:PhenotypicFeature	Wheezing	A high-pitched whistling sound associated with labored breathing.	MSH:D012135|UMLS:C0043144|SNOMEDCT_US:56018004	hp.json	Wheezing	http://purl.obolibrary.org/obo/HP_0030828		
HP:0030829	biolink:PhenotypicFeature	Abnormal breath sound	An anomalous (adventitious) sound produced by the breathing process.	SNOMEDCT_US:301273002|UMLS:C0231856	hp.json	Abnormal lung auscultation finding	http://purl.obolibrary.org/obo/HP_0030829		
HP:0003273	biolink:PhenotypicFeature	Hip contracture		SNOMEDCT_US:202283002|UMLS:C0409354	hp.json	Flexion contractures of hips|Flexion contracture of hips|Hip flexion contractures|Hip contractures	http://purl.obolibrary.org/obo/HP_0003273		
UBERON:0015172	biolink:AnatomicalEntity	endometrial blood vessel	A blood vessel that is part of a endometrium.	SCTID:254200009	hp.json	blood vessel of endometrium	http://purl.obolibrary.org/obo/UBERON_0015172		
CHEBI:83955	biolink:ChemicalSubstance	2-saturated fatty acid anion	A fatty acid anion obtained by deprotonation of the carboxy group of any 2-saturated fatty acid.		hp.json	a 1,2-saturated fatty acid|1,2-saturated fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_83955		3_STAR
UBERON:0015179	biolink:AnatomicalEntity	somite boundary epithelium	Epithelium located in the intersomitic region.	XAO:0004077	hp.json	intersomitic epithelium|intersomitic membrane	http://purl.obolibrary.org/obo/UBERON_0015179		
UBERON:0015178	biolink:AnatomicalEntity	somite border	A region of somite adjacent to presomitic mesoderm.	XAO:0004074|ZFA:0001462|TAO:0001462	hp.json	somite boundary|intersomitic junction|inter-somited border|intersomitic boundary|intersomitic fissure|segmental border	http://purl.obolibrary.org/obo/UBERON_0015178		pheno_slim
HP:0030833	biolink:PhenotypicFeature	Neck pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the neck.	UMLS:C0007859|MSH:D019547|SNOMEDCT_US:81680005	hp.json	Neck pain	http://purl.obolibrary.org/obo/HP_0030833		
HP:0003247	biolink:PhenotypicFeature	Overgrowth of external genitalia		UMLS:C1851722	hp.json	Overgrowth of external genitalia	http://purl.obolibrary.org/obo/HP_0003247		
HP:0003246	biolink:PhenotypicFeature	Prominent scrotal raphe	Increased size of the ridge of tissue that extends along the midline of the scrotum.	UMLS:C1852407	hp.json	Prominent perineal raphe	http://purl.obolibrary.org/obo/HP_0003246		
HP:0030834	biolink:PhenotypicFeature	Shoulder pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the shoulder.	UMLS:C0037011|MSH:D020069|SNOMEDCT_US:45326000	hp.json	Shoulder pain	http://purl.obolibrary.org/obo/HP_0030834		
HP:0030835	biolink:PhenotypicFeature	Elbow pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the elbow.	SNOMEDCT_US:74323005|UMLS:C0239266	hp.json	Elbow pain	http://purl.obolibrary.org/obo/HP_0030835		
HP:0003244	biolink:PhenotypicFeature	Penile hypospadias	Location of the urethral opening on the inferior aspect of the penis.	SNOMEDCT_US:204888000|UMLS:C1691215	hp.json		http://purl.obolibrary.org/obo/HP_0003244		
HP:0030836	biolink:PhenotypicFeature	Wrist pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the wrist.	UMLS:C0221785|SNOMEDCT_US:202482009|SNOMEDCT_US:56608008	hp.json	Wrist pain	http://purl.obolibrary.org/obo/HP_0030836		
HP:0030830	biolink:PhenotypicFeature	Crackles	Crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position.	MSH:D012135|UMLS:C0034642|SNOMEDCT_US:48409008	hp.json	Rales|Crepitations	http://purl.obolibrary.org/obo/HP_0030830		
HP:0030831	biolink:PhenotypicFeature	Rhonchi	Abnormal breath sounds characterized by low-pitched, snoring or rattle-like sounds.	MSH:D012135|UMLS:C0035508|SNOMEDCT_US:24612001	hp.json		http://purl.obolibrary.org/obo/HP_0030831		
HP:0003249	biolink:PhenotypicFeature	Genital ulcers		UMLS:C0151281	hp.json	Genital ulcers	http://purl.obolibrary.org/obo/HP_0003249		
HP:0030832	biolink:PhenotypicFeature	Vitreous strands	Fiber- or rope-like opacities located within the vitreous humor.	UMLS:C0271408|SNOMEDCT_US:28167005	hp.json		http://purl.obolibrary.org/obo/HP_0030832		
HP:0003248	biolink:PhenotypicFeature	Gonadal tissue inappropriate for external genitalia or chromosomal sex		UMLS:C1860268	hp.json		http://purl.obolibrary.org/obo/HP_0003248		
HP:0030837	biolink:PhenotypicFeature	Finger pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the finger.	SNOMEDCT_US:18876004|UMLS:C0239589	hp.json	Finger pain	http://purl.obolibrary.org/obo/HP_0030837		
HP:0030838	biolink:PhenotypicFeature	Hip pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the hip.	UMLS:C0019559|SNOMEDCT_US:49218002	hp.json	Hip pain	http://purl.obolibrary.org/obo/HP_0030838		
HP:0030839	biolink:PhenotypicFeature	Knee pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee.	SNOMEDCT_US:30989003|UMLS:C0231749	hp.json	Pain under knee cap|Knee pain	http://purl.obolibrary.org/obo/HP_0030839		
HP:0003241	biolink:PhenotypicFeature	External genital hypoplasia	Underdevelopment of part or all of the external reproductive organs.	UMLS:C1855333	hp.json	Hypogenitalism|Underdevelopment of external reproductive organs|Small genitalia	http://purl.obolibrary.org/obo/HP_0003241		
HP:0003240	biolink:PhenotypicFeature	Increased phosphoribosylpyrophosphate synthetase level	Abnormally elevated level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate.	UMLS:C4025637	hp.json	Increased phosphoribosyl pyrophosphate synthetase activity|Increased PRPS1 activity	http://purl.obolibrary.org/obo/HP_0003240		
UBERON:0015165	biolink:AnatomicalEntity	multi-unit eye	An eye consisting of multiple light-sensing organs.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015165		
UBERON:0015161	biolink:AnatomicalEntity	inferior branch of oculomotor nerve	The inferior branch of the oculomotor nerve or the inferior division, the larger, divides into three branches. One passes beneath the optic nerve to the medial rectus. Another, to the inferior rectus. The third and longest runs forward between the inferior recti and lateralis to the inferior oblique. From the last a short thick branch is given off to the lower part of the ciliary ganglion, and forms its short root. All these branches enter the muscles on their ocular surfaces, with the exception of the nerve to the inferior oblique, which enters the muscle at its posterior border.	FMA:52573|AAO:0010632	hp.json	ramus inferior (nervus oculomotorius [III])|ramus inferior nervus oculomotorii|inferior division of oculomotor nerve|inferior ramus of oculomotor nerve|ventral ramus of occulomotor nerve|ventral ramus of oculomotor nerve|oculomotor nerve inferior division|ramus inferior nervi oculomotorii	http://purl.obolibrary.org/obo/UBERON_0015161		
HP:0030844	biolink:PhenotypicFeature	Undetectable pattern electroretinogram	Absent response to a pattern electroretinogram (PERG).	UMLS:C4280746	hp.json		http://purl.obolibrary.org/obo/HP_0030844		
HP:0003258	biolink:PhenotypicFeature	Glyoxalase deficiency		UMLS:C3279658	hp.json		http://purl.obolibrary.org/obo/HP_0003258		
HP:0030845	biolink:PhenotypicFeature	Heliotrope rash of eyelid	Heliotrope rash is a violaceous discoloration of the eyelids associated with periorbital edema.	UMLS:C4280745	hp.json		http://purl.obolibrary.org/obo/HP_0030845		
HP:0003256	biolink:PhenotypicFeature	Abnormality of the coagulation cascade	An abnormality of the coagulation cascade, which is comprised of the contact activation pathway (also known as the intrinsic pathway) and the tissue factor pathway (also known as the extrinsic pathway) as well as cofactors and regulators.	UMLS:C0005779|SNOMEDCT_US:362970003|MSH:D001778|SNOMEDCT_US:64779008	hp.json	Coagulopathy	http://purl.obolibrary.org/obo/HP_0003256		
HP:0030846	biolink:PhenotypicFeature	Abnormality of venous physiology	An anomaly of venous function.	UMLS:C4280744	hp.json		http://purl.obolibrary.org/obo/HP_0030846		
HP:0030847	biolink:PhenotypicFeature	Abnormal jugular venous pressure	An anomaly of the jugular venous pressure. The internal jugular veins, being continuous with the superior vena cava, provide a visible measure of the degree to which the systemic venous reservoir is filled. The vertical height above the right atrium to which they are distended and above which they are in a collapsed state provides an imperfect reflection of the right atrial pressure.	UMLS:C0520860|SNOMEDCT_US:62436006	hp.json		http://purl.obolibrary.org/obo/HP_0030847		
HP:0030840	biolink:PhenotypicFeature	Ankle pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the ankle.	SNOMEDCT_US:202490009|UMLS:C0238656|SNOMEDCT_US:247373008	hp.json	Ankle pain	http://purl.obolibrary.org/obo/HP_0030840		
HP:0030841	biolink:PhenotypicFeature	Toe pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the toe.	SNOMEDCT_US:285365001|UMLS:C0241416	hp.json	Toe pain	http://purl.obolibrary.org/obo/HP_0030841		
HP:0030842	biolink:PhenotypicFeature	Choking episodes	Incidents in which a piece of food or other objects get stuck in the upper airway and provoke coughing, gagging, inability to talk, and difficulty breathing.	UMLS:C4280747	hp.json		http://purl.obolibrary.org/obo/HP_0030842		
HP:0003259	biolink:PhenotypicFeature	Elevated circulating creatinine concentration	An increased amount of creatinine in the blood.	UMLS:C0700225|SNOMEDCT_US:166717003	hp.json	High blood creatinine level|Elevated serum creatinine|Elevated creatinine|Increased serum creatinine|Increased creatinine	http://purl.obolibrary.org/obo/HP_0003259		
HP:0030843	biolink:PhenotypicFeature	Cardiac amyloidosis	Extracellular deposition in cardiac tissue of a proteinaceous material that, when stained with Congo red, demonstrates apple-green birefringence under polarized light and that has a distinct color when stained with sulfated Alcian blue. Viewed with electron microscopy, the amyloid deposits are seen to be composed of a beta-sheet fibrillar material. These nonbranching fibrils have a diameter of 7.5 to 10 nm and are the result of protein misfolding.	SNOMEDCT_US:16573007|UMLS:C0268407	hp.json	Amyloid cardiomyopathy	http://purl.obolibrary.org/obo/HP_0030843		
HP:0003250	biolink:PhenotypicFeature	Aplasia of the vagina	Aplasia of the vagina.	UMLS:C0220763|UMLS:C1321884|MSH:C536523|UMLS:C1841990|SNOMEDCT_US:87380008|SNOMEDCT_US:248871003	hp.json	Absent vagina|Congenital absence of the vagina	http://purl.obolibrary.org/obo/HP_0003250		
HP:0003254	biolink:PhenotypicFeature	Abnormality of DNA repair	An abnormality of the process of DNA repair, that is, of the process of restoring DNA after damage.	UMLS:C4021848	hp.json		http://purl.obolibrary.org/obo/HP_0003254		
GO:0031076	biolink:BiologicalProcess	embryonic camera-type eye development	The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.		hp.json	embryonic eye development	http://purl.obolibrary.org/obo/GO_0031076		
HP:0030848	biolink:PhenotypicFeature	Elevated jugular venous pressure	Increased jugular venous pressure.	UMLS:C0520861|SNOMEDCT_US:22447003	hp.json		http://purl.obolibrary.org/obo/HP_0030848		
HP:0030849	biolink:PhenotypicFeature	Hepatojugular reflux	The examiner applies firm but persistent pressure over the liver for 10 seconds while observing the mean jugular venous pressure. Normally there is either no rise or only a transient (i.e., 2 to 3 sec) rise in mean jugular venous pressure. A sustained increase in the mean venous pressure until abdominal compression is released is abnormal and indicates impaired right heart function. This abnormal response is called hepatojugular reflux.	UMLS:C0239949|SNOMEDCT_US:72196001	hp.json		http://purl.obolibrary.org/obo/HP_0030849		
HP:0003252	biolink:PhenotypicFeature	Anteriorly displaced genitalia		UMLS:C1848653	hp.json		http://purl.obolibrary.org/obo/HP_0003252		
HP:0003251	biolink:PhenotypicFeature	Male infertility		MSH:D007248|UMLS:C0021364|SNOMEDCT_US:2904007	hp.json	Male infertility	http://purl.obolibrary.org/obo/HP_0003251		
UBERON:0005749	biolink:AnatomicalEntity	glomerular tuft	The capillary loops of the kidney that normally function as a filtration unit[MP].	EMAPA:28239	hp.json	glomerulus|glomerular capillary tuft	http://purl.obolibrary.org/obo/UBERON_0005749		pheno_slim
UBERON:0017732	biolink:AnatomicalEntity	raphe of scrotum	A ridge of tissue that extends along the midline of the scrotum.	FMA:75130	hp.json	scrotal raphe	http://purl.obolibrary.org/obo/UBERON_0017732		pheno_slim
HP:0005807	biolink:PhenotypicFeature	Absent distal phalanges	Aplasia (absence) of the distal phalanges.	UMLS:C1861339	hp.json	Absent outermost digital bones	http://purl.obolibrary.org/obo/HP_0005807		
HP:0005802	biolink:PhenotypicFeature	Coalescence of tarsal bones		UMLS:C4025130	hp.json		http://purl.obolibrary.org/obo/HP_0005802		
GO:0021700	biolink:BiologicalProcess	developmental maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.		hp.json		http://purl.obolibrary.org/obo/GO_0021700		goslim_chembl
GO:0021703	biolink:BiologicalProcess	locus ceruleus development	The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.		hp.json	locus coeruleus development|locus caeruleus development	http://purl.obolibrary.org/obo/GO_0021703		
UBERON:0005754	biolink:AnatomicalEntity	rostral part of nephrogenic cord	The initial renal anlage that develops from the most rostral part of the nephrogenic cord is termed the pronephros.		hp.json		http://purl.obolibrary.org/obo/UBERON_0005754		
GO:0021704	biolink:BiologicalProcess	locus ceruleus morphogenesis	The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.		hp.json		http://purl.obolibrary.org/obo/GO_0021704		
UBERON:0005753	biolink:AnatomicalEntity	caudal part of nephrogenic cord	The metanephros develops from the most caudal part of the nephrogenic cord that is itself derived from the intermediate plate mesoderm.		hp.json	rear portion of nephrogenic cord|rear part of nephrogenic cord|caudal portion of nephrogenic cord|caudal region of nephrogenic cord	http://purl.obolibrary.org/obo/UBERON_0005753		
GO:0021705	biolink:BiologicalProcess	locus ceruleus formation	The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.		hp.json		http://purl.obolibrary.org/obo/GO_0021705		
GO:0021706	biolink:BiologicalProcess	locus ceruleus maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.		hp.json		http://purl.obolibrary.org/obo/GO_0021706		
GO:0043062	biolink:BiologicalProcess	extracellular structure organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.		hp.json	extracellular structure organisation|extracellular structure organization and biogenesis	http://purl.obolibrary.org/obo/GO_0043062		goslim_pir
HP:0005819	biolink:PhenotypicFeature	Short middle phalanx of finger	Short (hypoplastic) middle phalanx of finger, affecting one or more fingers.	UMLS:C1846950	hp.json	Hypoplasia of the middle phalanges of the hand|Short middle phalanges|Hypoplastic middle phalanx|Hypoplastic middle phalanges|Brachymesophalangy|Shortened middle finger bones|Short middle bone of finger|Disproportionately short middle phalanges|Midphalangeal hypoplasia	http://purl.obolibrary.org/obo/HP_0005819		
GO:0043069	biolink:BiologicalProcess	negative regulation of programmed cell death	Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.		hp.json	down-regulation of programmed cell death|down regulation of programmed cell death|inhibition of programmed cell death|negative regulation of non-apoptotic programmed cell death|downregulation of programmed cell death	http://purl.obolibrary.org/obo/GO_0043069		
GO:0043068	biolink:BiologicalProcess	positive regulation of programmed cell death	Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.		hp.json	activation of programmed cell death|stimulation of programmed cell death|upregulation of programmed cell death|positive regulation of non-apoptotic programmed cell death|up-regulation of programmed cell death|up regulation of programmed cell death	http://purl.obolibrary.org/obo/GO_0043068		
GO:0043065	biolink:BiologicalProcess	positive regulation of apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.		hp.json	upregulation of apoptosis|pro-apoptosis|up-regulation of apoptosis|positive regulation of apoptosis|up regulation of apoptosis|activation of apoptosis|stimulation of apoptosis	http://purl.obolibrary.org/obo/GO_0043065		goslim_chembl
HP:0005815	biolink:PhenotypicFeature	Supernumerary ribs	The presence of more than 12 rib pairs.	SNOMEDCT_US:205460009|UMLS:C0345397	hp.json	Extra ribs	http://purl.obolibrary.org/obo/HP_0005815		hposlim_core
GO:0043067	biolink:BiologicalProcess	regulation of programmed cell death	Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.		hp.json	regulation of non-apoptotic programmed cell death	http://purl.obolibrary.org/obo/GO_0043067		
HP:0005817	biolink:PhenotypicFeature	Postaxial polysyndactyly of foot	Combined syndactyly and polydactyly of the foot on the lateral side (i.e., on the side of the little toe).	UMLS:C4021824	hp.json		http://purl.obolibrary.org/obo/HP_0005817		
GO:0043066	biolink:BiologicalProcess	negative regulation of apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.		hp.json	down-regulation of apoptosis|down regulation of apoptosis|apoptosis inhibitor activity|downregulation of apoptosis|inhibition of apoptosis|negative regulation of apoptosis|pro-survival|anti-apoptosis	http://purl.obolibrary.org/obo/GO_0043066		
UBERON:0017716	biolink:AnatomicalEntity	thenar eminence	A raised fleshy area on the palm of the hand near the base of the thumb.	FMA:61520	hp.json	thenar part of palm	http://purl.obolibrary.org/obo/UBERON_0017716		pheno_slim
UBERON:0017717	biolink:AnatomicalEntity	hypothenar eminence	Hypothenar refers to a group of three muscles of the palm that control the motion of the little finger. The three muscles are: Abductor digiti minimi Flexor digiti minimi Opponens digiti minimi.	FMA:61523	hp.json	hypothenar part of palm	http://purl.obolibrary.org/obo/UBERON_0017717		pheno_slim
UBERON:0005745	biolink:AnatomicalEntity	optic foramen	An opening in the skull through which cranial nerve II passes.[MP].	AAO:0000342|FMA:54774|EMAPA:18716|EHDAA:10646|ZFA:0005428|VHOG:0001408|EHDAA2:0001312|TAO:0002025	hp.json	optic canal|optic nerve foramen|canalis opticus|foramen opticum ossis sphenoidalis|optic foramen|optic nerve (II) foramen	http://purl.obolibrary.org/obo/UBERON_0005745		vertebrate_core|pheno_slim
GO:0070664	biolink:BiologicalProcess	negative regulation of leukocyte proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.		hp.json	down-regulation of leukocyte proliferation|down regulation of leukocyte proliferation|inhibition of leukocyte proliferation|downregulation of leukocyte proliferation	http://purl.obolibrary.org/obo/GO_0070664		
GO:0070665	biolink:BiologicalProcess	positive regulation of leukocyte proliferation	Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.		hp.json	upregulation of leukocyte proliferation|up-regulation of leukocyte proliferation|up regulation of leukocyte proliferation|activation of leukocyte proliferation|stimulation of leukocyte proliferation	http://purl.obolibrary.org/obo/GO_0070665		
UBERON:0005744	biolink:AnatomicalEntity	bone foramen	Anatomical space that is an opening in a bone, usually for passage of blood vessels or nerves.	TAO:0001736|VHOG:0001760|AAO:0010438|ZFA:0005386	hp.json	foramen	http://purl.obolibrary.org/obo/UBERON_0005744		vertebrate_core
UBERON:0005742	biolink:AnatomicalEntity	adventitia	An outermost connective tissue covering of an organ, vessel, or other structure[WP].	BTO:0002010|SCTID:30180000|Wikipedia:Adventitia|FMA:45635|MESH:D063194	hp.json	tunica advetitia|tunica externa|tunica advetitia	http://purl.obolibrary.org/obo/UBERON_0005742		human_reference_atlas|grouping_class
GO:0070663	biolink:BiologicalProcess	regulation of leukocyte proliferation	Any process that modulates the frequency, rate or extent of leukocyte proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0070663		
GO:0070661	biolink:BiologicalProcess	leukocyte proliferation	The expansion of a leukocyte population by cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0070661		
UBERON:0005740	biolink:AnatomicalEntity	tunica intima of artery	A tunica intima that is part of a artery.	galen:IntimaOfArtery|EV:0100028|SCTID:40022005|FMA:14272|EMAPA:36293	hp.json	tunica interna (intima)(arteriae)|arterial intima	http://purl.obolibrary.org/obo/UBERON_0005740		
GO:0043073	biolink:CellularComponent	germ cell nucleus	The nucleus of a germ cell, a reproductive cell in multicellular organisms.		hp.json	germ-cell nucleus	http://purl.obolibrary.org/obo/GO_0043073		
UBERON:0005729	biolink:AnatomicalEntity	pectoral appendage field	A limb/fin field that has the potential to develop into a pectoral appendage bud mesenchyme.	ZFA:0001453|TAO:0001453	hp.json	pectoral fin field|pectoral appendage field of lateral plate mesoderm	http://purl.obolibrary.org/obo/UBERON_0005729		
UBERON:0005728	biolink:AnatomicalEntity	extraembryonic mesoderm	.	VHOG:0000616|EHDAA2:0000474|EMAPA:31863|EMAPA:31862|FMA:296719	hp.json	extra-embryonic mesoderm|extraembryonic mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005728		
UBERON:0005726	biolink:AnatomicalEntity	chemosensory system		BILA:0000139	hp.json		http://purl.obolibrary.org/obo/UBERON_0005726		functional_classification
GO:0055059	biolink:BiologicalProcess	asymmetric neuroblast division	The process resulting in the physical partitioning and separation of a neuroblast into two daughter cells with different developmental potentials.		hp.json		http://purl.obolibrary.org/obo/GO_0055059		
UBERON:0005734	biolink:AnatomicalEntity	tunica adventitia of blood vessel	The outermost layer of a blood vessel, composed mainly of fibrous tissue.	UMLS:C0225342|NCIT:C33818|Wikipedia:Tunica_externa_(vessels)|BTO:0002010|EMAPA:36299|SCTID:61066005	hp.json	adventitia externa|tunica adventitia|external coat|tunica adventitia of vessel|tunica adventitia vasorum|tunica adventitia vasorum|adventitia externa|tunica adventitia|tunica adventitia of vessel|external coat|tunica externa vasorum|tunica externa vasorum	http://purl.obolibrary.org/obo/UBERON_0005734		
UBERON:0005733	biolink:AnatomicalEntity	limb field	A ring of cells capable of forming a limb.		hp.json	limb field of lateral plate mesoderm	http://purl.obolibrary.org/obo/UBERON_0005733		
UBERON:0005732	biolink:AnatomicalEntity	paired limb/fin field	A ring of cells capable of forming a limb or paired fin[Gilbert,modified].		hp.json	limb/fin field of lateral plate mesoderm|paired limb/fin field	http://purl.obolibrary.org/obo/UBERON_0005732		homology_grouping
UBERON:0005730	biolink:AnatomicalEntity	pelvic appendage field	A limb/fin field that has the potential to develop into a pelvic appendage bud mesenchyme.	ZFA:0001454|TAO:0001454	hp.json	pelvic appendage field of lateral plate mesoderm|pelvic fin field	http://purl.obolibrary.org/obo/UBERON_0005730		
GO:0055057	biolink:BiologicalProcess	neuroblast division	The process resulting in the physical partitioning and separation of a neuroblast into daughter cells. A neuroblast is any cell that will divide and give rise to a neuron.		hp.json	neuroblast cell division	http://purl.obolibrary.org/obo/GO_0055057		
GO:0043085	biolink:BiologicalProcess	positive regulation of catalytic activity	Any process that activates or increases the activity of an enzyme.		hp.json	up-regulation of metalloenzyme activity|stimulation of metalloenzyme activity|up-regulation of enzyme activity|positive regulation of enzyme activity|activation of metalloenzyme activity|upregulation of metalloenzyme activity|up regulation of enzyme activity|activation of enzyme activity|positive regulation of metalloenzyme activity|stimulation of enzyme activity|up regulation of metalloenzyme activity|upregulation of enzyme activity	http://purl.obolibrary.org/obo/GO_0043085		goslim_chembl
GO:0043084	biolink:BiologicalProcess	penile erection	The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.	Wikipedia:Erection#Penile_erection	hp.json		http://purl.obolibrary.org/obo/GO_0043084		
UBERON:0005719	biolink:AnatomicalEntity	footplate apical ectodermal ridge	An apical ectodermal ridge that is part of a footplate.	EMAPA:17251|EHDAA2:0000547	hp.json		http://purl.obolibrary.org/obo/UBERON_0005719		
GO:0043086	biolink:BiologicalProcess	negative regulation of catalytic activity	Any process that stops or reduces the activity of an enzyme.		hp.json	down-regulation of enzyme activity|downregulation of metalloenzyme activity|down regulation of enzyme activity|down regulation of metalloenzyme activity|inhibition of enzyme activity|downregulation of enzyme activity|negative regulation of metalloenzyme activity|negative regulation of enzyme activity|inhibition of metalloenzyme activity|down-regulation of metalloenzyme activity	http://purl.obolibrary.org/obo/GO_0043086		
CHEBI:20392	biolink:ChemicalSubstance	4-hydroxyproline	A monohydroxyproline where the hydroxy group is located at the 4-position. It is found in  fibrillar collagen.	PMID:436278|PMID:21988268|PMID:24695516|Wikipedia:Hydroxyproline|PMID:24563386	hp.json	4-hydroxyproline|4Hyp	http://purl.obolibrary.org/obo/CHEBI_20392		3_STAR
HP:0030800	biolink:PhenotypicFeature	Abnormal visual accommodation	An anomaly in the process of visual accommodation, which is the process of adjustment of the eye to enable sharp vision of objects at different distances. Accommodation is mediated by contraction of the ciliary muscles, which alter the convexity of the lens and, consequently, its refractive power.	UMLS:C4280760	hp.json		http://purl.obolibrary.org/obo/HP_0030800		
GO:0055062	biolink:BiologicalProcess	phosphate ion homeostasis	Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0055062		
HP:0030801	biolink:PhenotypicFeature	Reduced visual accommodation	A decreased ability of the eye to adjust and thereby enable sharp vision of objects at different distances.	UMLS:C4280759	hp.json		http://purl.obolibrary.org/obo/HP_0030801		
GO:0055063	biolink:BiologicalProcess	sulfate ion homeostasis	Any process involved in the maintenance of an internal steady state of sulfate ions within an organism or cell.		hp.json	sulphate ion homeostasis|sulfate homeostasis	http://purl.obolibrary.org/obo/GO_0055063		
HP:0030802	biolink:PhenotypicFeature	Lower eyelid retraction	Inferior malposition of the lower eyelid margin without eyelid eversion.	UMLS:C1861656|SNOMEDCT_US:700264006	hp.json		http://purl.obolibrary.org/obo/HP_0030802		
HP:0030803	biolink:PhenotypicFeature	Platonychia	Abnormal flat nail.	UMLS:C1853986	hp.json		http://purl.obolibrary.org/obo/HP_0030803		
GO:0055064	biolink:BiologicalProcess	chloride ion homeostasis	Any process involved in the maintenance of an internal steady state of chloride ions within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0055064		
UBERON:0005725	biolink:AnatomicalEntity	olfactory system	A sensory system that is capable of olfaction (the sensory perception of smell).	UMLS:C0228065|AAO:0000334|EFO:0001973|NLXANAT:090806|XAO:0003196|BILA:0000144|NCIT:C94501|FMA:7190|EMAPA:36004|ZFA:0001149|AAO:0000978|OpenCyc:Mx4rvViw75wpEbGdrcN5Y29ycA|TAO:0001149|MA:0002445	hp.json		http://purl.obolibrary.org/obo/UBERON_0005725		pheno_slim|efo_slim|vertebrate_core
GO:0055069	biolink:BiologicalProcess	zinc ion homeostasis	Any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell.		hp.json	zinc homeostasis	http://purl.obolibrary.org/obo/GO_0055069		
HP:0030808	biolink:PhenotypicFeature	Ragged cuticle	The cuticle (properly known as the eponychium, or the medial nail fold or the proximal nail fold), is the thickened layer of skin surrounding fingernails and toenails. Its function is to protect the area between the nail and epidermis from exposure to bacteria. This term refers to the presence of and irregular edge or outline of the cuticle.	UMLS:C4280756	hp.json		http://purl.obolibrary.org/obo/HP_0030808		
UBERON:0005724	biolink:AnatomicalEntity	roof plate spinal cord region	A tissue that is part of a spinal cord and is part of a roof plate.	TAO:0001177|VHOG:0000777|EMAPA:17586|XAO:0000022|ZFA:0001177	hp.json	spinal cord roof|roofplate spinal cord|roof plate spinal cord	http://purl.obolibrary.org/obo/UBERON_0005724		
HP:0030809	biolink:PhenotypicFeature	Abnormal tongue morphology	Any structural anomaly of the tongue.	UMLS:C4280755	hp.json		http://purl.obolibrary.org/obo/HP_0030809		
UBERON:0005721	biolink:AnatomicalEntity	pronephric mesoderm	A mesoderm that has the potential to develop into a pronephros.	TAO:0000067|VHOG:0001239|EFO:0003479|ZFA:0000067|XAO:0000264|AAO:0011090	hp.json	pronephric mesenchyme|pronephric bulge|pronephric primordium|pronephric anlage	http://purl.obolibrary.org/obo/UBERON_0005721		efo_slim
HP:0030804	biolink:PhenotypicFeature	Trachyonychia	Excessive longitudinal ridging that gives the surface of the nail plate a rough appearance. It results from multiple foci of defective keratinization of the proximal nail matrix.	SNOMEDCT_US:69192004|UMLS:C0546956	hp.json		http://purl.obolibrary.org/obo/HP_0030804		
GO:0055065	biolink:BiologicalProcess	metal ion homeostasis	Any process involved in the maintenance of an internal steady state of metal ions within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0055065		goslim_generic|prokaryote_subset|goslim_pombe
UBERON:0005720	biolink:AnatomicalEntity	hindbrain venous system	A venous system that is part of a hindbrain.	VHOG:0001322|EMAPA:18632|EHDAA2:0000776	hp.json	rhombencephalon venous system	http://purl.obolibrary.org/obo/UBERON_0005720		
HP:0030805	biolink:PhenotypicFeature	Absent lunula	Lack of the lunula at the base of a nail. The lunula is the crescent-shaped whitish area of the bed of a fingernail or toenail.	UMLS:C4280758	hp.json	Lunula absent|Lunulae absent|Absent lunulae	http://purl.obolibrary.org/obo/HP_0030805		
GO:0055067	biolink:BiologicalProcess	monovalent inorganic cation homeostasis	Any process involved in the maintenance of an internal steady state of monovalent inorganic cations within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0055067		
HP:0030806	biolink:PhenotypicFeature	Fast-growing nails	Nails whose growth is quicker than normal.	UMLS:C4280757	hp.json		http://purl.obolibrary.org/obo/HP_0030806		
HP:0030807	biolink:PhenotypicFeature	Abnormal nail growth	Nail whose growth pattern or speed deviates from normal.	UMLS:C1610609	hp.json		http://purl.obolibrary.org/obo/HP_0030807		
UBERON:0015111	biolink:AnatomicalEntity	distal tarsal bone 4 endochondral element			hp.json	distal tarsal 4	http://purl.obolibrary.org/obo/UBERON_0015111		
UBERON:0015110	biolink:AnatomicalEntity	distal tarsal bone 3 pre-cartilage condensation	A distal tarsal bone 3 endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015110		
UBERON:0015116	biolink:AnatomicalEntity	distal tarsal bone 5 pre-cartilage condensation	A distal tarsal bone 5 endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015116		
HGNC:6563	biolink:Gene	LGALS3 (human)	A protein coding gene LGALS3 in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6563		
UBERON:0015113	biolink:AnatomicalEntity	distal tarsal bone 4 pre-cartilage condensation	A distal tarsal bone 4 endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015113		
HP:0005848	biolink:PhenotypicFeature	obsolete Bifid thumb distal phalanx			hp.json		http://purl.obolibrary.org/obo/HP_0005848		
UBERON:0015112	biolink:AnatomicalEntity	distal tarsal bone 4 cartilage	A distal tarsal bone 4 endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015112		
HP:0005849	biolink:PhenotypicFeature	Diffuse cerebral calcification	Generalized deposition of calcium salts within the brain.	UMLS:C4025125	hp.json		http://purl.obolibrary.org/obo/HP_0005849		
UBERON:0015115	biolink:AnatomicalEntity	distal tarsal bone 5 cartilage	A distal tarsal bone 5 endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015115		
UBERON:0015114	biolink:AnatomicalEntity	distal tarsal bone 5 endochondral element			hp.json	distal tarsal 5	http://purl.obolibrary.org/obo/UBERON_0015114		
HP:0005844	biolink:PhenotypicFeature	Rounded middle phalanx of finger	An abnormally round shape of the middle phalanx of the finger.	UMLS:C4025126	hp.json	Rounded middle bone of finger	http://purl.obolibrary.org/obo/HP_0005844		
GO:0055072	biolink:BiologicalProcess	iron ion homeostasis	Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.		hp.json	iron homeostasis	http://purl.obolibrary.org/obo/GO_0055072		
UBERON:0005792	biolink:AnatomicalEntity	nephric ridge	Nephric tubules (nephrons) form embryonically along the nephric ridge. The ridge comprises three regions; anterior, middle and posterior. The functional kidney uses nephrons from only one or two regions of the ridge. A pronephric kidney uses only the nephrons from the anterior region of the ridge. A mesonephric kidney uses only the middle region, a metanephric kidney uses only the posterior region and an opisthonephric kidney uses the middle and posterior regions.	EHDAA:1015|EHDAA2:0001242|EMAPA:16368|VHOG:0001240	hp.json	nephric cord	http://purl.obolibrary.org/obo/UBERON_0005792		
GO:0055074	biolink:BiologicalProcess	calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.		hp.json	regulation of calcium ion concentration	http://purl.obolibrary.org/obo/GO_0055074		
UBERON:0015109	biolink:AnatomicalEntity	distal tarsal bone 3 cartilage	A distal tarsal bone 3 endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015109		
HP:0005841	biolink:PhenotypicFeature	Calcific stippling of infantile cartilaginous skeleton		UMLS:C1859135	hp.json		http://purl.obolibrary.org/obo/HP_0005841		
GO:0055071	biolink:BiologicalProcess	manganese ion homeostasis	Any process involved in the maintenance of an internal steady state of manganese ions within an organism or cell.		hp.json	manganese homeostasis	http://purl.obolibrary.org/obo/GO_0055071		
GO:0055076	biolink:BiologicalProcess	transition metal ion homeostasis	Any process involved in the maintenance of an internal steady state of transition metal ions within an organism or cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.		hp.json		http://purl.obolibrary.org/obo/GO_0055076		
UBERON:0003135	biolink:AnatomicalEntity	male reproductive organ	A male organ involved in reproduction.	MA:0000545|WBbt:0008423	hp.json	male reproductive system organ|reproductive organ of male organism|male genital|reproductive structure of male organism|male organism sex organ|male organism reproductive structure|male organism reproductive system organ|reproductive system organ of male organism|male organism reproductive organ|sex organ of male organism|male reproductive gland/organ|male sex organ	http://purl.obolibrary.org/obo/UBERON_0003135		organ_slim|pheno_slim
UBERON:0003133	biolink:AnatomicalEntity	reproductive organ	An organ involved in reproduction.	MA:0001752|MESH:D005835|TGMA:0000591|UMLS:C0017420|OpenCyc:Mx4rwO39aJwpEbGdrcN5Y29ycA|SCTID:128181006|EMAPA:37731|EMAPA:17381|NCIT:C25177|WBbt:0008422	hp.json	sex organ|genital organ|reproductive system organ|genitalia	http://purl.obolibrary.org/obo/UBERON_0003133		functional_classification|organ_slim|pheno_slim
UBERON:0003134	biolink:AnatomicalEntity	female reproductive organ	A female organ involved in reproduction.	MA:0000544|EMAPA:28540	hp.json	female reproductive system organ|reproductive structure of female organism|female organism sex organ|female organism reproductive system organ|female organism reproductive structure|reproductive system organ of female organism|female organism reproductive organ|female reproductive gland/organ|sex organ of female organism|female sex organ|reproductive organ of female organism	http://purl.obolibrary.org/obo/UBERON_0003134		organ_slim|pheno_slim
UBERON:0005795	biolink:AnatomicalEntity	embryonic uterus		FMA:72173|SCTID:255782009	hp.json	fetal uterus	http://purl.obolibrary.org/obo/UBERON_0005795		
UBERON:0015100	biolink:AnatomicalEntity	distal tarsal cartilage	A distal tarsal endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015100		
UBERON:0003119	biolink:AnatomicalEntity	pharyngeal arch artery 2	The vessels formed within the second pair of branchial arches in embryogenesis.	VHOG:0000148|EHDAA2:0000051|AAO:0010418|EMAPA:16203|EMAPA:16686|XAO:0000343|Wikipedia:Aortic_arches#Arches_1_and_2|SCTID:308775002|ZFA:0005006|TAO:0005006	hp.json	second aortic arch|aortic arch 2|2nd aortic arch artery|2nd pharyngeal arch artery|2nd branchial arch artery|hyoid aortic arch|2nd arch artery|second branchial arch artery|AA2	http://purl.obolibrary.org/obo/UBERON_0003119		vertebrate_core|pheno_slim
UBERON:0015106	biolink:AnatomicalEntity	distal tarsal bone 2 cartilage	A distal tarsal bone 2 endochondral element that is composed primarily of cartilage tissue.		hp.json	distal tarsal 2 cartilage|distal tarsal 2 cartilage element	http://purl.obolibrary.org/obo/UBERON_0015106		
UBERON:0015105	biolink:AnatomicalEntity	distal tarsal bone 2 endochondral element			hp.json	distal tarsal 2	http://purl.obolibrary.org/obo/UBERON_0015105		
UBERON:0015108	biolink:AnatomicalEntity	distal tarsal bone 3 endochondral element			hp.json	distal tarsal 3	http://purl.obolibrary.org/obo/UBERON_0015108		
UBERON:0015107	biolink:AnatomicalEntity	distal tarsal bone 2 pre-cartilage condensation	A distal tarsal bone 2 endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015107		
UBERON:0015102	biolink:AnatomicalEntity	distal tarsal bone 1 endochondral element			hp.json	distal tarsal 1	http://purl.obolibrary.org/obo/UBERON_0015102		
UBERON:0015101	biolink:AnatomicalEntity	distal tarsal bone pre-cartilage condensation	A distal tarsal endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015101		
UBERON:0015104	biolink:AnatomicalEntity	distal tarsal bone 1 pre-cartilage condensation	A distal tarsal bone 1 endochondral element that is composed primarily of a pre-cartilage condensation.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015104		
UBERON:0015103	biolink:AnatomicalEntity	distal tarsal bone 1 cartilage	A distal tarsal bone 1 endochondral element that is composed primarily of cartilage tissue.		hp.json	distal tarsal 1 cartilage|distal tarsal 1 cartilage element	http://purl.obolibrary.org/obo/UBERON_0015103		
GO:0055083	biolink:BiologicalProcess	monovalent inorganic anion homeostasis	Any process involved in the maintenance of an internal steady state of monovalent inorganic anions within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0055083		
UBERON:0003120	biolink:AnatomicalEntity	pharyngeal arch artery 3	The vessels formed within the third pair of branchial arches in embryogenesis.	XAO:0000344|ZFA:0005007|SCTID:308776001|TAO:0005007|Wikipedia:Aortic_arches#Arch_3|VHOG:0000147|AAO:0010419|EHDAA2:0000070|EMAPA:16687	hp.json	carotid arch|third branchial arch artery|carotid arch|3rd arch artery|AA3|3rd branchial arch artery|third aortic arch|3rd aortic arch artery|aortic arch 3|3rd pharyngeal arch artery	http://purl.obolibrary.org/obo/UBERON_0003120		vertebrate_core|pheno_slim
HP:0005855	biolink:PhenotypicFeature	Multiple prenatal fractures	The presence of bone fractures in the prenatal period that are diagnosed at birth or before.	UMLS:C1853171	hp.json	Numerous multiple fractures that are present at birth|Numerous multiple fractures present at birth|Multiple fractures, present at birth|Congenital bone fractures|Multiple fractures present at birth	http://purl.obolibrary.org/obo/HP_0005855		
UBERON:0003121	biolink:AnatomicalEntity	pharyngeal arch artery 4	The vessels formed within the fourth pair of branchial arches in embryogenesis.	XAO:0000355|ZFA:0005008|SCTID:308777005|EMAPA:17004|TAO:0005008|AAO:0010420|Wikipedia:Aortic_arches#Arch_4|EHDAA2:0000087	hp.json	4th pharyngeal arch artery|fourth branchial arch artery|4th branchial arch artery|systemic arch|fourth aortic arch|AA4|4th arch artery|4th aortic arch artery|aortic arch 4	http://purl.obolibrary.org/obo/UBERON_0003121		vertebrate_core|pheno_slim
HP:0005856	biolink:PhenotypicFeature	Ulnar radial head dislocation	A dislocation of the head of the radius from its socket in the elbow joint in an ulnar direction.	UMLS:C4021619	hp.json	Ulnar dislocation of radial heads	http://purl.obolibrary.org/obo/HP_0005856		
GO:0055085	biolink:BiologicalProcess	transmembrane transport	The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.		hp.json	membrane transport|ATP hydrolysis coupled transmembrane transport	http://purl.obolibrary.org/obo/GO_0055085		goslim_yeast|goslim_generic|goslim_pombe|goslim_drosophila|goslim_chembl
HP:0005857	biolink:PhenotypicFeature	Cervical spina bifida		SNOMEDCT_US:32232003|UMLS:C0266501	hp.json		http://purl.obolibrary.org/obo/HP_0005857		
GO:0055086	biolink:BiologicalProcess	nucleobase-containing small molecule metabolic process	The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.		hp.json	nucleobase, nucleoside and nucleotide metabolic process|nucleobase, nucleoside and nucleotide metabolism	http://purl.obolibrary.org/obo/GO_0055086		goslim_generic|goslim_yeast|prokaryote_subset|goslim_pombe|goslim_drosophila
HP:0005852	biolink:PhenotypicFeature	Limited elbow extension and supination		UMLS:C4025124	hp.json		http://purl.obolibrary.org/obo/HP_0005852		
GO:0055080	biolink:BiologicalProcess	cation homeostasis	Any process involved in the maintenance of an internal steady state of cations within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0055080		
GO:0055081	biolink:BiologicalProcess	anion homeostasis	Any process involved in the maintenance of an internal steady state of anions within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0055081		
HP:0005853	biolink:PhenotypicFeature	Congenital foot contraction deformities		UMLS:C4025123	hp.json		http://purl.obolibrary.org/obo/HP_0005853		
GO:0055082	biolink:BiologicalProcess	cellular chemical homeostasis	Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell.		hp.json		http://purl.obolibrary.org/obo/GO_0055082		
UBERON:0003128	biolink:AnatomicalEntity	cranium	Upper portion of the skull that excludes the mandible (when present in the organism).	MA:0000316|MIAA:0000340|SCTID:181889008|OpenCyc:Mx4rvVlEyJwpEbGdrcN5Y29ycA|FMA:71325|BTO:0001328|EFO:0000831|EHDAA:6029|Wikipedia:Cranium_(anatomy)|EMAPA:17680|MAT:0000340|VHOG:0000334	hp.json	bones of cranium|upper part of skull|skull minus mandible|set of bones of cranium|epicranial plate|calvarium|skeletal system of head|ossa cranii	http://purl.obolibrary.org/obo/UBERON_0003128		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0003129	biolink:AnatomicalEntity	skull	Anatomical structure that is part of the head consisting entirely of cranium and mandible[WP].	UMLS:C0037303|FMA:46565|BTO:0001295|GAID:82|CALOHA:TS-2344|OpenCyc:Mx4rvVjOsZwpEbGdrcN5Y29ycA|galen:Skull|NCIT:C12789|EHDAA2:0000325|MESH:D012886|Wikipedia:Skull|SCTID:110530005|EMAPA:17680|WikipediaCategory:Skull	hp.json	cranial skeleton|skeletal system of head	http://purl.obolibrary.org/obo/UBERON_0003129		uberon_slim|pheno_slim
UBERON:0003126	biolink:AnatomicalEntity	trachea	The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph].	EMAPA:16853|NCIT:C12428|EFO:0000935|VHOG:0000371|MAT:0000137|MA:0000441|GAID:361|EHDAA:3078|CALOHA:TS-1060|FMA:7394|MIAA:0000137|BTO:0001388|EHDAA2:0002066|OpenCyc:Mx4rvViOX5wpEbGdrcN5Y29ycA|XAO:0000118|MESH:D014132|AAO:0010140|EV:0100040|UMLS:C0040578	hp.json	cartilaginous trachea|vertebrate trachea|tracheal tubule|windpipe	http://purl.obolibrary.org/obo/UBERON_0003126		uberon_slim|major_organ|pheno_slim|efo_slim|human_reference_atlas
UBERON:0005788	biolink:AnatomicalEntity	lamina rara interna	Layer of the glomerular basement membrane adjacent to the glomerular capillary.	NCIT:C32920|UMLS:C1517719|ZFA:0005287|FMA:74277|TAO:0005287	hp.json	internal layer of glomerular basement membrane|lamina interna of glomerular basement membrane	http://purl.obolibrary.org/obo/UBERON_0005788		vertebrate_core
HP:0005850	biolink:PhenotypicFeature	Congenital talipes calcaneovalgus		UMLS:C0152237|SNOMEDCT_US:31668003|MSH:D005413|SNOMEDCT_US:205083002	hp.json		http://purl.obolibrary.org/obo/HP_0005850		
UBERON:0003124	biolink:AnatomicalEntity	chorion membrane	The outermost extraembryonic membrane of amniotes.	EFO:0002780|CALOHA:TS-0144|MESH:D002823|UMLS:C1516505|Wikipedia:Chorion|EMAPA:16112|UMLS:C0008503|FMA:80224|EHDAA2:0000245|NCIT:C34124|NCIT:C34122|MESH:A16.254.403.473|EV:0100121|GAID:1299|EHDAA:150|VHOG:0000200|BTO:0000252	hp.json	fetal chorion|uterine chorion|chorion|chorionic sac|uterine chorion|chorion frondosum|chorion (vertebrates)|embryonic chorion|chorionic sac|chorion frondosum	http://purl.obolibrary.org/obo/UBERON_0003124		uberon_slim|pheno_slim|efo_slim
GO:0055088	biolink:BiologicalProcess	lipid homeostasis	Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0055088		
UBERON:0003122	biolink:AnatomicalEntity	pharyngeal arch artery 5	The vessels formed within the fifth pair of pharyngeal arches in embryogenesis.	ZFA:0005009|XAO:0000352|TAO:0005009|AAO:0010421|VHOG:0000145	hp.json	fifth aortic arch|AA5|aortic arch 5	http://purl.obolibrary.org/obo/UBERON_0003122		vertebrate_core
UBERON:0003123	biolink:AnatomicalEntity	pharyngeal arch artery 6	The vessels formed within the sixth pair of branchial arches in embryogenesis.	SCTID:308779008|EMAPA:17005|XAO:0000353|ZFA:0005016|AAO:0010422|EHDAA2:0000102|Wikipedia:Aortic_arches#Arch_6|TAO:0005016|VHOG:0000144	hp.json	6th aortic arch artery|6th arch artery|6th pharyngeal arch artery|AA6|6th branchial arch artery|pulmonary arch|sixth branchial arch artery|aortic arch 6|sixth aortic arch	http://purl.obolibrary.org/obo/UBERON_0003123		vertebrate_core|pheno_slim
UBERON:0017750	biolink:AnatomicalEntity	proximal mesopodial endochondral element	A mesopodial endochondral element that is in the most proximal part of the mesopodial skeleton, connected to the zeugopodial skeleton.		hp.json		http://purl.obolibrary.org/obo/UBERON_0017750		
UBERON:0017751	biolink:AnatomicalEntity	proximal mesopodial cartilage element	A proximal mesopodial endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0017751		
CHEBI:58958	biolink:ChemicalSubstance	organosulfate oxoanion	An organic anion of general formula RS(=O)2O(-) where R is an organyl group.		hp.json	organosulfate oxoanions	http://purl.obolibrary.org/obo/CHEBI_58958		3_STAR
HP:0005828	biolink:PhenotypicFeature	Transient pulmonary infiltrates		UMLS:C3805920	hp.json		http://purl.obolibrary.org/obo/HP_0005828		
HP:0005829	biolink:PhenotypicFeature	Maldevelopment of radioulnar joint		UMLS:C3149879	hp.json		http://purl.obolibrary.org/obo/HP_0005829		
UBERON:0003110	biolink:AnatomicalEntity	otic region		AAO:0010208|ZFA:0000189|TAO:0000189|XAO:0003175	hp.json	cranial vault	http://purl.obolibrary.org/obo/UBERON_0003110		
HP:0005824	biolink:PhenotypicFeature	Clinodactyly of the 2nd toe	Bending or curvature of a second toe in the tibial direction (i.e., towards the big toe).	UMLS:C4280473|UMLS:C4021620	hp.json	Curvature of 2nd toe|Clinodactyly of second toes	http://purl.obolibrary.org/obo/HP_0005824		
HP:0005825	biolink:PhenotypicFeature	Mixed sclerosis of humeral metaphyses		UMLS:C4025128	hp.json		http://purl.obolibrary.org/obo/HP_0005825		
HP:0005820	biolink:PhenotypicFeature	Superior rib anomalies		UMLS:C4025129	hp.json		http://purl.obolibrary.org/obo/HP_0005820		
UBERON:0003117	biolink:AnatomicalEntity	pharyngeal arch 6	The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles.	SCTID:308772004|EHDAA2:0004075|TAO:0001601|XAO:0000453|AAO:0010368|ZFA:0001609|EMAPA:32766|FMA:293047|VHOG:0001205	hp.json	fourth branchial arch|gill arch 4|sixth visceral arch|6th pharyngeal arch|sixth branchial arch|6th arch|6th visceral arch|sixth pharyngeal arch|visceral arch 6|branchial arch 4	http://purl.obolibrary.org/obo/UBERON_0003117		pheno_slim
CHEBI:58956	biolink:ChemicalSubstance	branched-chain saturated fatty acid anion	Any saturated fatty acid anion with a carbon side-chain or isopropyl termination.		hp.json	branched-chain saturated fatty acid anions	http://purl.obolibrary.org/obo/CHEBI_58956		3_STAR
CHEBI:58955	biolink:ChemicalSubstance	branched-chain fatty acid anion	Any fatty acid anion with a carbon side-chain or isopropyl termination.		hp.json	branched-chain fatty acid anions	http://purl.obolibrary.org/obo/CHEBI_58955		3_STAR
UBERON:0003118	biolink:AnatomicalEntity	pharyngeal arch artery 1	The vessels formed within the first pair of branchial arches in embryogenesis.	EMAPA:16202|SCTID:308774003|AAO:0010415|EMAPA:16685|EHDAA2:0000007|XAO:0000342|ZFA:0005005|TAO:0005005|VHOG:0000149	hp.json	1st branchial arch artery|first branchial arch artery|aortic arch 1|first arch artery|first aortic arch|mandibular aortic arch|1st aortic arch artery|1st arch artery|AA1|1st pharyngeal arch artery	http://purl.obolibrary.org/obo/UBERON_0003118		vertebrate_core|pheno_slim
UBERON:0003115	biolink:AnatomicalEntity	pharyngeal arch 4	Contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus.	VHOG:0000299|EMAPA:16760|TAO:0001599|EHDAA:1663|AAO:0010366|ZFA:0001607|SCTID:308770007|FMA:293035|EHDAA2:0000086|XAO:0000449	hp.json	4th visceral arch|fourth visceral arch|visceral arch 4|4th branchial arch|second branchial arch|fourth pharyngeal arch|second gill arch|4th pharyngeal arch|4th arch|branchial arch 2|gill arch 2	http://purl.obolibrary.org/obo/UBERON_0003115		uberon_slim|vertebrate_core|pheno_slim
CHEBI:58954	biolink:ChemicalSubstance	straight-chain saturated fatty acid anion	Any saturated fatty acid anion lacking a carbon side-chain.		hp.json	straight-chain saturated fatty acid anions	http://purl.obolibrary.org/obo/CHEBI_58954		3_STAR
UBERON:0005777	biolink:AnatomicalEntity	glomerular basement membrane	The layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter.	TAO:0005285|FMA:74274|MESH:D050533|EMAPA:30965|NCIT:C32683|EMAPA:28251|ZFA:0005285|UMLS:C0599297|MA:0001659	hp.json	glomerular capillary basement membrane|glomerular filtration membrane|GBM	http://purl.obolibrary.org/obo/UBERON_0005777		vertebrate_core|pheno_slim
CHEBI:58953	biolink:ChemicalSubstance	saturated fatty acid anion	Any fatty acid anion in which there is no C-C unsaturation.		hp.json	saturated fatty acid anions	http://purl.obolibrary.org/obo/CHEBI_58953		3_STAR
UBERON:0003116	biolink:AnatomicalEntity	pharyngeal arch 5		TAO:0001600|XAO:0000451|AAO:0010367|ZFA:0001608|FMA:293045|VHOG:0001204	hp.json	gill arch 3|5th pharyngeal arch|fifth pharyngeal arch|third branchial arch|5th visceral arch|branchial arch 3|branchial arch 3|visceral arch 5|fifth visceral arch	http://purl.obolibrary.org/obo/UBERON_0003116		
UBERON:0003113	biolink:AnatomicalEntity	dermatocranium	Subdivision of skeleton that includes all dermal bones in the cranial skeleton[ZFA,modified].	ZFA:0000863|TAO:0000863|XAO:0003169|Wikipedia:Skull_roof|AAO:0010154|VHOG:0001665	hp.json	exocranium|dermal part of skull|skull exoskeleton|dermal skull roof|dermal skull roof|dermal bone cranium|dermal skull bones|roof of skull|roofing bones of the skull|roof of skull|roofing bones of the skull|skull roof|skull roof|dendrocranium|dermatocranial cover	http://purl.obolibrary.org/obo/UBERON_0003113		
UBERON:0003114	biolink:AnatomicalEntity	pharyngeal arch 3	The third branchial arch contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus.	VHOG:0000298|EHDAA:1080|EMAPA:16399|SCTID:308769006|TAO:0001598|FMA:293029|EHDAA2:0000069|AAO:0010365|ZFA:0001606|XAO:0000447	hp.json	gill arch 1|3rd pharyngeal arch|3rd arch|first gill arch|third visceral arch|visceral arch 3|first branchial arch|3rd visceral arch|third pharyngeal arch|branchial arch 1	http://purl.obolibrary.org/obo/UBERON_0003114		vertebrate_core|pheno_slim
CHEBI:58951	biolink:ChemicalSubstance	short-chain fatty acid anion	Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6).		hp.json	short-chain fatty acid anions|a short-chain fatty acid	http://purl.obolibrary.org/obo/CHEBI_58951		3_STAR
UBERON:0003111	biolink:AnatomicalEntity	sphenoid region	Anatomical cluster that forms the floor and sidewalls of the middle part of the cranium.	TAO:0000290|AAO:0010207|XAO:0003174|ZFA:0000290	hp.json		http://purl.obolibrary.org/obo/UBERON_0003111		
UBERON:0003112	biolink:AnatomicalEntity	olfactory region	Anatomical cluster that is located in the anterior region of the cranium and provides structural support for the olfactory organ.	NCIT:C98765|AAO:0010206|ZFA:0000351|EFO:0003525|TAO:0000351|XAO:0003172	hp.json	ethmoid region	http://purl.obolibrary.org/obo/UBERON_0003112		efo_slim
UBERON:0017748	biolink:AnatomicalEntity	lower primary incisor tooth	A primary incisor tooth that is part of a lower jaw region.	FMA:84215	hp.json	primary lower incisor tooth|lower deciduous incisor tooth|deciduous lower incisor tooth	http://purl.obolibrary.org/obo/UBERON_0017748		pheno_slim
HP:0005837	biolink:PhenotypicFeature	obsolete Joint dislocations in young adult			hp.json		http://purl.obolibrary.org/obo/HP_0005837		
HGNC:6553	biolink:Gene	LEP (human)	A protein coding gene LEP in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6553		
HP:0005833	biolink:PhenotypicFeature	obsolete Joint swelling onset late infancy			hp.json		http://purl.obolibrary.org/obo/HP_0005833		
HP:0005834	biolink:PhenotypicFeature	obsolete Thumbs hypo/aplastic			hp.json		http://purl.obolibrary.org/obo/HP_0005834		
HP:0005830	biolink:PhenotypicFeature	Flexion contracture of toe	One or more bent (flexed) toe joints that cannot be straightened actively or passively.	UMLS:C1406835	hp.json	Toe contractures|Contractures involving the toes|Contractures of the toes	http://purl.obolibrary.org/obo/HP_0005830		
HP:0005831	biolink:PhenotypicFeature	Type B brachydactyly		UMLS:C1862112|MSH:C566196	hp.json		http://purl.obolibrary.org/obo/HP_0005831		
HP:0005832	biolink:PhenotypicFeature	Dysharmonic delayed bone age	A type of dysharmonic skeletal maturation in which there is a delay in skeletal maturation whose degree differs markedly in different bones.	UMLS:C1859444	hp.json		http://purl.obolibrary.org/obo/HP_0005832		
CHEBI:58945	biolink:ChemicalSubstance	organophosphate oxoanion	An organic phosphoric acid derivative in which one or more oxygen atoms of the phosphate group(s) has been deprotonated.		hp.json	organophosphate oxoanions	http://purl.obolibrary.org/obo/CHEBI_58945		3_STAR
UBERON:0005769	biolink:AnatomicalEntity	basement membrane of epithelium	An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina.	Wikipedia:Basement_membrane|NCIT:C13191|UMLS:C0004799|SCTID:68989006|GAID:915|AAO:0010596|FMA:63872	hp.json	basement membrane of connective tissue|membrana basalis|basement membrane|membrana basalis	http://purl.obolibrary.org/obo/UBERON_0005769		
UBERON:0003107	biolink:AnatomicalEntity	Meckel's cartilage	Meckel's cartilage is the bilaterally paired, rod-like, cartilaginous ventral component of the lower jar, or ventral mandibular arch. It is typically resorbed in adults.	XAO:0003085|MA:0001580|FMA:295784|EMAPA:17635|EHDAA2:0001072|ZFA:0001205|TAO:0001205|EHDAA:7997|AAO:0000289|VHOG:0000249	hp.json	primary mandinle|ventral mandibular cartilage|cartilago arcus pharyngei primi|Meckels cartilage	http://purl.obolibrary.org/obo/UBERON_0003107		uberon_slim|vertebrate_core|pheno_slim
UBERON:0003104	biolink:AnatomicalEntity	mesenchyme	Portion of tissue composed of mesenchymal cells (motile cells that develop from epthelia via an epithelial to mesenchymal transition) and surrounding extracellular material. Mesenchyme has different embryological origins in different metazoan taxa - in many invertebrates it derives in whole or part from ectoderm. In vertebrates it derives largely from mesoderm, and sometimes the terms are used interchangeably, e.g. lateral plate mesoderm/mesenchyme.	AEO:0000145|CALOHA:TS-0620|AAO:0010427|BTO:0001393|EV:0100007|Wikipedia:Mesenchyme|XAO:0003046|VHOG:0000170|NCIT:C13301|ZFA:0000393|UMLS:C0162415|EHDAA2:0003145|TAO:0000393	hp.json	mesenchyma|portion of mesenchymal tissue|mesenchymal tissue|portion of mesenchyme tissue|mesenchyme tissue|mesenchyma	http://purl.obolibrary.org/obo/UBERON_0003104		uberon_slim|vertebrate_core|pheno_slim
UBERON:0003102	biolink:AnatomicalEntity	surface structure	Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism.	TAO:0000292|VSAO:0000001|galen:SurfaceRegion|XAO:0003028|Wikipedia:Surface_structure|EHDAA2_RETIRED:0003010|AAO:0010337|AEO_RETIRED:0000010|ZFA:0000292	hp.json	surface structures|anatomical surface feature|surface region|surface feature	http://purl.obolibrary.org/obo/UBERON_0003102		upper_level
UBERON:0003103	biolink:AnatomicalEntity	compound organ	Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types.	BILA:0000024|AEO:0000024|CARO:0000024|HAO:0000024|ZFA:0000496|AAO:0010015|TAO:0000496|TGMA:0001837|VHOG:0001723|TADS:0000598|XAO:0003041|EHDAA2:0003024	hp.json	organ	http://purl.obolibrary.org/obo/UBERON_0003103		upper_level|organ_slim
UBERON:0005764	biolink:AnatomicalEntity	acellular membrane	An acellular anatomical structure that is the bounding layer of a anatomical structure.	FMA:63871	hp.json		http://purl.obolibrary.org/obo/UBERON_0005764		
UBERON:0003100	biolink:AnatomicalEntity	female organism	Gonochoristic organism that can produce female gametes.	AAO:0010030|HAO:0000028|ZFA:0000303|XAO:0003005|TAO:0000303|SCTID:362608006|TGMA:0001839|BILA:0000028|FMA:67812|CARO:0000028|FBbt:00007011	hp.json	female human body|female	http://purl.obolibrary.org/obo/UBERON_0003100		vertebrate_core|pheno_slim
UBERON:0003101	biolink:AnatomicalEntity	male organism	Gonochoristic organism that can produce male gametes.	HAO:0000027|XAO:0003006|WBbt:0007850|ZFA:0000242|TGMA:0001838|FBbt:00007004|TAO:0000242|BILA:0000027|FMA:67811|AAO:0010033|CARO:0000027	hp.json	male|male human body	http://purl.obolibrary.org/obo/UBERON_0003101		vertebrate_core|pheno_slim
GO:0043217	biolink:BiologicalProcess	myelin maintenance	The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath.		hp.json		http://purl.obolibrary.org/obo/GO_0043217		
GO:0070831	biolink:BiologicalProcess	basement membrane assembly	The aggregation, arrangement and bonding together of a set of components to form a basement membrane, a part of the extracellular region that consists of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0070831		
GO:0021895	biolink:BiologicalProcess	cerebral cortex neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.		hp.json		http://purl.obolibrary.org/obo/GO_0021895		
GO:0031214	biolink:BiologicalProcess	biomineral tissue development	Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.	Wikipedia:Biomineralization	hp.json		http://purl.obolibrary.org/obo/GO_0031214		
GO:0006281	biolink:BiologicalProcess	DNA repair	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.	Wikipedia:DNA_repair	hp.json		http://purl.obolibrary.org/obo/GO_0006281		goslim_drosophila|goslim_generic|goslim_yeast|prokaryote_subset|goslim_pombe|goslim_pir
GO:0070828	biolink:BiologicalProcess	heterochromatin organization	Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin.		hp.json	heterochromatin organisation	http://purl.obolibrary.org/obo/GO_0070828		
GO:0006282	biolink:BiologicalProcess	regulation of DNA repair	Any process that modulates the frequency, rate or extent of DNA repair.		hp.json		http://purl.obolibrary.org/obo/GO_0006282		goslim_metagenomics
GO:0043227	biolink:CellularComponent	membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.	NIF_Subcellular:sao414196390	hp.json	membrane-enclosed organelle	http://purl.obolibrary.org/obo/GO_0043227		
GO:0043226	biolink:CellularComponent	organelle	Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.	Wikipedia:Organelle|NIF_Subcellular:sao1539965131	hp.json		http://purl.obolibrary.org/obo/GO_0043226		goslim_chembl|goslim_generic|prokaryote_subset|goslim_pir
GO:0043229	biolink:CellularComponent	intracellular organelle	Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0043229		goslim_pir
GO:0043228	biolink:CellularComponent	non-membrane-bounded organelle	Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.	NIF_Subcellular:sao1456184038	hp.json	non-membrane-enclosed organelle|biological condensate	http://purl.obolibrary.org/obo/GO_0043228		goslim_mouse
GO:0021884	biolink:BiologicalProcess	forebrain neuron development	The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0021884		
GO:0021885	biolink:BiologicalProcess	forebrain cell migration	The orderly movement of a cell from one site to another at least one of which is located in the forebrain.		hp.json		http://purl.obolibrary.org/obo/GO_0021885		
GO:0043233	biolink:CellularComponent	organelle lumen	The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.		hp.json		http://purl.obolibrary.org/obo/GO_0043233		goslim_mouse
PR:000007597	biolink:Protein	protein c-Fos	A protein that is a translation product of the human FOS gene or a 1:1 ortholog thereof.		hp.json	cellular oncogene fos|G0/G1 switch regulatory protein 7|FOS|transcription factor AP-1 subunit c-Fos|proto-oncogene protein c-fos|G0S7	http://purl.obolibrary.org/obo/PR_000007597		
GO:0043235	biolink:CellularComponent	receptor complex	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.		hp.json		http://purl.obolibrary.org/obo/GO_0043235		goslim_pir
GO:0043230	biolink:CellularComponent	extracellular organelle	Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.		hp.json		http://purl.obolibrary.org/obo/GO_0043230		goslim_pir
GO:0043232	biolink:CellularComponent	intracellular non-membrane-bounded organelle	Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.		hp.json	intracellular non-membrane-enclosed organelle	http://purl.obolibrary.org/obo/GO_0043232		goslim_pir
GO:0043231	biolink:CellularComponent	intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.		hp.json	intracellular membrane-enclosed organelle	http://purl.obolibrary.org/obo/GO_0043231		goslim_pir
GO:0070859	biolink:NamedThing	positive regulation of bile acid biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0070859		
GO:0070857	biolink:NamedThing	regulation of bile acid biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0070857		
GO:0070858	biolink:NamedThing	negative regulation of bile acid biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0070858		
GO:0070851	biolink:MolecularActivity	growth factor receptor binding	Binding to a growth factor receptor.		hp.json		http://purl.obolibrary.org/obo/GO_0070851		
GO:0021872	biolink:BiologicalProcess	forebrain generation of neurons	The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons.		hp.json	generation of neurons in forebrain	http://purl.obolibrary.org/obo/GO_0021872		
GO:0006259	biolink:BiologicalProcess	DNA metabolic process	Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.		hp.json	cellular DNA metabolism|DNA metabolism	http://purl.obolibrary.org/obo/GO_0006259		goslim_agr|goslim_candida|goslim_plant|goslim_pir|goslim_flybase_ribbon|goslim_chembl|goslim_metagenomics
GO:0043244	biolink:BiologicalProcess	regulation of protein-containing complex disassembly	Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.		hp.json	regulation of protein complex disassembly	http://purl.obolibrary.org/obo/GO_0043244		
GO:0043243	biolink:BiologicalProcess	positive regulation of protein-containing complex disassembly	Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.		hp.json	up regulation of protein complex disassembly|activation of protein complex disassembly|stimulation of protein complex disassembly|positive regulation of protein complex disassembly|upregulation of protein complex disassembly|up-regulation of protein complex disassembly	http://purl.obolibrary.org/obo/GO_0043243		
GO:0043242	biolink:BiologicalProcess	negative regulation of protein-containing complex disassembly	Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.		hp.json	down-regulation of protein complex disassembly|down regulation of protein complex disassembly|negative regulation of protein complex disassembly|downregulation of protein complex disassembly|inhibition of protein complex disassembly	http://purl.obolibrary.org/obo/GO_0043242		
GO:0043249	biolink:BiologicalProcess	erythrocyte maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.		hp.json	red blood cell maturation|RBC maturation	http://purl.obolibrary.org/obo/GO_0043249		
GO:0021879	biolink:BiologicalProcess	forebrain neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.		hp.json		http://purl.obolibrary.org/obo/GO_0021879		
GO:0021863	biolink:BiologicalProcess	forebrain neuroblast differentiation	The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate.		hp.json	non-surface dividing progenitor cell differentiation|intermediate progenitor cell differentiation|abventricular progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_0021863		
GO:0043255	biolink:BiologicalProcess	regulation of carbohydrate biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates.		hp.json	regulation of carbohydrate anabolism|regulation of carbohydrate synthesis|regulation of carbohydrate biosynthesis|regulation of carbohydrate formation	http://purl.obolibrary.org/obo/GO_0043255		
GO:0043254	biolink:BiologicalProcess	regulation of protein-containing complex assembly	Any process that modulates the frequency, rate or extent of protein complex assembly.		hp.json	regulation of protein complex assembly	http://purl.obolibrary.org/obo/GO_0043254		
GO:0070875	biolink:NamedThing	positive regulation of glycogen metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0070875		
GO:0070873	biolink:NamedThing	regulation of glycogen metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0070873		
GO:0070874	biolink:NamedThing	negative regulation of glycogen metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0070874		
UBERON:0005814	biolink:AnatomicalEntity	arch of atlas	A vertebral arch that is part of the first cervical vertebra.	FMA:23975	hp.json	atlas arch	http://purl.obolibrary.org/obo/UBERON_0005814		
GO:0043269	biolink:BiologicalProcess	regulation of ion transport	Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0043269		
GO:0043264	biolink:CellularComponent	extracellular non-membrane-bounded organelle	Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.		hp.json	extracellular non-membrane-enclosed organelle	http://purl.obolibrary.org/obo/GO_0043264		
GO:0043270	biolink:BiologicalProcess	positive regulation of ion transport	Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	up regulation of ion transport|activation of ion transport|stimulation of ion transport|upregulation of ion transport|up-regulation of ion transport	http://purl.obolibrary.org/obo/GO_0043270		
UBERON:0005809	biolink:AnatomicalEntity	cortex of manus bone	The outer or sperficial part of a bone of the manus.		hp.json		http://purl.obolibrary.org/obo/UBERON_0005809		
UBERON:0005808	biolink:AnatomicalEntity	bone tissue of long bone	A bone tissue that is part of a long bone.	FMA:83117	hp.json	osseous tissue of long bone	http://purl.obolibrary.org/obo/UBERON_0005808		
GO:0043271	biolink:BiologicalProcess	negative regulation of ion transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	down-regulation of ion transport|down regulation of ion transport|downregulation of ion transport|inhibition of ion transport	http://purl.obolibrary.org/obo/GO_0043271		
UBERON:0005806	biolink:AnatomicalEntity	portal system	In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP].	UMLS:C0226727|FMA:45628|NCIT:C33344|MESH:D011168	hp.json	portal venous system	http://purl.obolibrary.org/obo/UBERON_0005806		
UBERON:0005805	biolink:AnatomicalEntity	dorsal aorta	The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.	BTO:0004673|VHOG:0000264|ZFA:0000014|EHDAA:402|AAO:0011029|Wikipedia:Dorsal_aorta|TAO:0000014|SCTID:338637006|XAO:0000051|EMAPA:18606	hp.json	aortae dorsales|dorsal aortae|dorsal aortæ|dorsal aortæ|dorsal aortae|DA|dorsal aortic root|dorsal aorta root|aortae dorsales|aorta dorsalis	http://purl.obolibrary.org/obo/UBERON_0005805		vertebrate_core
GO:0006206	biolink:BiologicalProcess	pyrimidine nucleobase metabolic process	The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.		hp.json	pyrimidine metabolic process|pyrimidine base metabolism|pyrimidine metabolism|pyrimidine base metabolic process	http://purl.obolibrary.org/obo/GO_0006206		
GO:0043279	biolink:BiologicalProcess	response to alkaloid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.		hp.json		http://purl.obolibrary.org/obo/GO_0043279		
UBERON:0005813	biolink:AnatomicalEntity	tubercle	A round nodule, small eminence, or warty outgrowth on an anatomical surface, such as bones, skin, or within the lungs (in the case of tuberculosis). They are also found on the leading edge of Humpback Whale's flippers, improving fluid flow over the flipper's surface[WP].	BTO:0002173|FMA:75429|AAO:0010605	hp.json	tuber	http://purl.obolibrary.org/obo/UBERON_0005813		upper_level|grouping_class
GO:0021846	biolink:BiologicalProcess	cell proliferation in forebrain	The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.		hp.json		http://purl.obolibrary.org/obo/GO_0021846		
GO:0070887	biolink:BiologicalProcess	cellular response to chemical stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0070887		gocheck_do_not_manually_annotate
UBERON:0005800	biolink:AnatomicalEntity	section of aorta	Any portion of the aorta including the ascending and descending aorta, and aortic arch or a portion of the aortic orifice of the left ventricle.	SCTID:119203005|FMA:13087|NCIT:C34027|UMLS:C0506947	hp.json	aortic section|aortic segment|portion of aorta|segment of aorta	http://purl.obolibrary.org/obo/UBERON_0005800		
CHEBI:22918	biolink:ChemicalSubstance	branched-chain amino acid	Any  amino acid  in which the parent hydrocarbon chain has one or more alkyl substituents		hp.json	branched chain amino acids	http://purl.obolibrary.org/obo/CHEBI_22918		3_STAR
GO:0045818	biolink:NamedThing	negative regulation of glycogen catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0045818		
GO:0045815	biolink:BiologicalProcess	epigenetic maintenance of chromatin in transcription-competent conformation	An epigenetic process that capacitates gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA.		hp.json	maintenance of chromatin in transcription-competent conformation|activation of gene expression, epigenetic|euchromatin assembly|chromatin-mediated maintenance of transcription|up-regulation of gene expression, epigenetic|euchromatin organization|stimulation of gene expression, epigenetic|up regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|upregulation of gene expression, epigenetic|long-term maintenance of gene activation|euchromatin organisation	http://purl.obolibrary.org/obo/GO_0045815		
GO:0045814	biolink:BiologicalProcess	negative regulation of gene expression, epigenetic	An epigenetic process that stops, prevents or reduces the rate of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA.		hp.json	gene silencing|downregulation of gene expression, epigenetic|inhibition of gene expression, epigenetic|down-regulation of gene expression, epigenetic|down regulation of gene expression, epigenetic	http://purl.obolibrary.org/obo/GO_0045814		
GO:0045819	biolink:NamedThing	positive regulation of glycogen catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0045819		
PR:Q06278	biolink:Protein	aldehyde oxidase (human)	An aldehyde oxidase that is encoded in the genome of human.	Reactome:R-HSA-3204326|UniProtKB:Q06278	hp.json	AO|hAOX1|AOX1|aldehyde oxidase 1 (human)|azaheterocycle hydroxylase (human)	http://purl.obolibrary.org/obo/PR_Q06278		
GO:0045820	biolink:BiologicalProcess	negative regulation of glycolytic process	Any process that stops, prevents, or reduces the frequency, rate or extent of glycolysis.		hp.json	downregulation of glycolysis|down regulation of glycolysis|inhibition of glycolysis|down-regulation of glycolysis	http://purl.obolibrary.org/obo/GO_0045820		
GO:0045821	biolink:BiologicalProcess	positive regulation of glycolytic process	Any process that activates or increases the frequency, rate or extent of glycolysis.		hp.json	up regulation of glycolysis|stimulation of glycolysis|up-regulation of glycolysis|activation of glycolysis|upregulation of glycolysis	http://purl.obolibrary.org/obo/GO_0045821		
GO:0045828	biolink:BiologicalProcess	positive regulation of isoprenoid metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.		hp.json	upregulation of isoprenoid metabolic process|up regulation of isoprenoid metabolic process|positive regulation of isoprenoid metabolism|stimulation of isoprenoid metabolic process|up-regulation of isoprenoid metabolic process|activation of isoprenoid metabolic process	http://purl.obolibrary.org/obo/GO_0045828		
GO:0031270	biolink:BiologicalProcess	pseudopodium retraction	The myosin-based contraction and retraction of a pseudopodium.		hp.json		http://purl.obolibrary.org/obo/GO_0031270		
GO:0045827	biolink:BiologicalProcess	negative regulation of isoprenoid metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving isoprenoid.		hp.json	down regulation of isoprenoid metabolic process|inhibition of isoprenoid metabolic process|down-regulation of isoprenoid metabolic process|downregulation of isoprenoid metabolic process|negative regulation of isoprenoid metabolism	http://purl.obolibrary.org/obo/GO_0045827		
GO:0045824	biolink:BiologicalProcess	negative regulation of innate immune response	Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response.		hp.json	downregulation of innate immune response|down regulation of innate immune response|inhibition of innate immune response|down-regulation of innate immune response	http://purl.obolibrary.org/obo/GO_0045824		
GO:0045822	biolink:BiologicalProcess	negative regulation of heart contraction	Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.		hp.json	down regulation of heart contraction|inhibition of heart contraction|downregulation of heart contraction|down-regulation of heart contraction|negative regulation of cardiac contraction	http://purl.obolibrary.org/obo/GO_0045822		
GO:0045823	biolink:BiologicalProcess	positive regulation of heart contraction	Any process that activates or increases the frequency, rate or extent of heart contraction.		hp.json	upregulation of heart contraction|up-regulation of heart contraction|positive regulation of cardiac contraction|up regulation of heart contraction|activation of heart contraction|stimulation of heart contraction	http://purl.obolibrary.org/obo/GO_0045823		
GO:0031274	biolink:BiologicalProcess	positive regulation of pseudopodium assembly	Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.		hp.json	up-regulation of pseudopodium formation|positive regulation of pseudopodium formation|upregulation of pseudopodium formation|stimulation of pseudopodium formation|activation of pseudopodium formation|up regulation of pseudopodium formation	http://purl.obolibrary.org/obo/GO_0031274		
GO:0031272	biolink:BiologicalProcess	regulation of pseudopodium assembly	Any process that modulates the frequency, rate or extent of the assembly of pseudopodia.		hp.json	regulation of pseudopodium formation	http://purl.obolibrary.org/obo/GO_0031272		
GO:0031273	biolink:BiologicalProcess	negative regulation of pseudopodium assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia.		hp.json	downregulation of pseudopodium formation|inhibition of pseudopodium formation|down regulation of pseudopodium formation|negative regulation of pseudopodium formation|down-regulation of pseudopodium formation	http://purl.obolibrary.org/obo/GO_0031273		
HP:0040333	biolink:PhenotypicFeature	Confluent hypointensity of cerebral white matter on MRI			hp.json		http://purl.obolibrary.org/obo/HP_0040333		
HP:0040334	biolink:PhenotypicFeature	Purulent rhinitis	Chronic rhinitis accompanied by pus formation.		hp.json		http://purl.obolibrary.org/obo/HP_0040334		
GO:0031269	biolink:BiologicalProcess	pseudopodium assembly	The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane.		hp.json	pseudopodium formation|pseudopodium extension	http://purl.obolibrary.org/obo/GO_0031269		
GO:0045839	biolink:BiologicalProcess	negative regulation of mitotic nuclear division	Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.		hp.json	negative regulation of mitosis|down-regulation of mitosis|down regulation of mitosis|inhibition of mitosis|downregulation of mitosis	http://purl.obolibrary.org/obo/GO_0045839		
GO:0045835	biolink:BiologicalProcess	negative regulation of meiotic nuclear division	Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.		hp.json	inhibition of meiosis|downregulation of meiosis|negative regulation of meiosis|down-regulation of meiosis|down regulation of meiosis	http://purl.obolibrary.org/obo/GO_0045835		
GO:0045836	biolink:BiologicalProcess	positive regulation of meiotic nuclear division	Any process that activates or increases the frequency, rate or extent of meiosis.		hp.json	up-regulation of meiosis|up regulation of meiosis|activation of meiosis|positive regulation of meiosis|stimulation of meiosis|upregulation of meiosis	http://purl.obolibrary.org/obo/GO_0045836		
GO:0045833	biolink:BiologicalProcess	negative regulation of lipid metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipids.		hp.json	downregulation of lipid metabolic process|inhibition of lipid metabolic process|negative regulation of lipid metabolism|down-regulation of lipid metabolic process|down regulation of lipid metabolic process	http://purl.obolibrary.org/obo/GO_0045833		
GO:0045834	biolink:BiologicalProcess	positive regulation of lipid metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipids.		hp.json	up-regulation of lipid metabolic process|up regulation of lipid metabolic process|activation of lipid metabolic process|positive regulation of lipid metabolism|stimulation of lipid metabolic process|upregulation of lipid metabolic process	http://purl.obolibrary.org/obo/GO_0045834		
GO:0031268	biolink:BiologicalProcess	pseudopodium organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.		hp.json	pseudopodium organisation|pseudopodium organization and biogenesis	http://purl.obolibrary.org/obo/GO_0031268		
HP:0040331	biolink:PhenotypicFeature	Focal hypointensity of cerebral white matter on MRI			hp.json		http://purl.obolibrary.org/obo/HP_0040331		
HP:0040332	biolink:PhenotypicFeature	Multifocal hypointensity of cerebral white matter on MRI			hp.json		http://purl.obolibrary.org/obo/HP_0040332		
HP:0040330	biolink:PhenotypicFeature	Confluent hyperintensity of cerebral white matter on MRI	Areas of brighter than expected MRI signal in the white matter of the brain whereby individual patches run together.		hp.json		http://purl.obolibrary.org/obo/HP_0040330		
UBERON:0039175	biolink:AnatomicalEntity	subarachnoid space of brain		FMA:322073	hp.json		http://purl.obolibrary.org/obo/UBERON_0039175		
UBERON:0039176	biolink:AnatomicalEntity	subarachnoid space of spinal cord		FMA:322074	hp.json		http://purl.obolibrary.org/obo/UBERON_0039176		
GO:0045843	biolink:BiologicalProcess	negative regulation of striated muscle tissue development	Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle development.		hp.json	down-regulation of striated muscle development|down regulation of striated muscle development|downregulation of striated muscle development|inhibition of striated muscle development	http://purl.obolibrary.org/obo/GO_0045843		
GO:0045840	biolink:BiologicalProcess	positive regulation of mitotic nuclear division	Any process that activates or increases the frequency, rate or extent of mitosis.		hp.json	upregulation of mitosis|mitogenic activity|up-regulation of mitosis|up regulation of mitosis|activation of mitosis|positive regulation of mitosis|stimulation of mitosis	http://purl.obolibrary.org/obo/GO_0045840		
GO:0045844	biolink:BiologicalProcess	positive regulation of striated muscle tissue development	Any process that activates or increases the frequency, rate or extent of striated muscle development.		hp.json	up regulation of striated muscle development|activation of striated muscle development|stimulation of striated muscle development|upregulation of striated muscle development|up-regulation of striated muscle development	http://purl.obolibrary.org/obo/GO_0045844		
GO:0031256	biolink:CellularComponent	leading edge membrane	The portion of the plasma membrane surrounding the leading edge of a motile cell.		hp.json		http://purl.obolibrary.org/obo/GO_0031256		
GO:0031252	biolink:CellularComponent	cell leading edge	The area of a motile cell closest to the direction of movement.		hp.json	front of cell|leading edge of cell	http://purl.obolibrary.org/obo/GO_0031252		goslim_pir
GO:0031253	biolink:CellularComponent	cell projection membrane	The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.		hp.json	membrane extension|membrane projection	http://purl.obolibrary.org/obo/GO_0031253		
MPATH:387	biolink:NamedThing	odontoma	Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0).		hp.json		http://purl.obolibrary.org/obo/MPATH_387		
GO:0043200	biolink:BiologicalProcess	response to amino acid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.		hp.json	response to amino acid stimulus	http://purl.obolibrary.org/obo/GO_0043200		
GO:0043209	biolink:CellularComponent	myelin sheath	An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.	FMA:62983|NIF_Subcellular:sao593830697|Wikipedia:Myelin	hp.json	astrocyte sheath|Schwann cell myelin sheath|oligodendrocyte myelin sheath	http://purl.obolibrary.org/obo/GO_0043209		
GO:0043207	biolink:BiologicalProcess	response to external biotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.		hp.json		http://purl.obolibrary.org/obo/GO_0043207		
MPATH:379	biolink:NamedThing	odontogenic tumor	Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) .		hp.json		http://purl.obolibrary.org/obo/MPATH_379		
CHEBI:22860	biolink:ChemicalSubstance	amino-acid betaine	Any amino acid-derived zwitterion - such as glycine betaine (N,N,N-trimethylammonioacetate) - in which the ammonium nitrogen carries methyl substituents and bears no hydrogen atoms.		hp.json	amino-acid betaines|amino acid betaines|betaines	http://purl.obolibrary.org/obo/CHEBI_22860		3_STAR
HP:0030970	biolink:PhenotypicFeature	Abnormal vena cava physiology	An abnormality of the function of the veins that return deoxygenated blood from the body into the heart, i.e., the superior vena cava and the inferior vena cava.		hp.json		http://purl.obolibrary.org/obo/HP_0030970		
HP:0030971	biolink:PhenotypicFeature	obsolete Abnormal vena cava morphology			hp.json		http://purl.obolibrary.org/obo/HP_0030971		
UBERON:0003296	biolink:AnatomicalEntity	gland of diencephalon	Any gland that is part of the diencephalon. Examples: pineal gland, neurohypophysis.	EHDAA:4475|EHDAA2:0000395|VHOG:0000653|EMAPA:16897	hp.json	diencephalon gland|interbrain gland	http://purl.obolibrary.org/obo/UBERON_0003296		
HP:0030976	biolink:PhenotypicFeature	Abnormal factor VIII activity	A deviation from the normal activity of coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X.		hp.json		http://purl.obolibrary.org/obo/HP_0030976		
UBERON:0003297	biolink:AnatomicalEntity	gland of integumental system	A gland that is part of a integumental system [Automatically generated definition].	EHDAA:6522|VHOG:0000654|EMAPA:17758|EHDAA2:0000837|MA:0000144	hp.json	integumental system gland|integumental system gland|integumental gland|integumental gland|integumentary gland|integumentary gland	http://purl.obolibrary.org/obo/UBERON_0003297		
HP:0003345	biolink:PhenotypicFeature	Elevated urinary norepinephrine	An increased concentration of noradrenaline in the urine.	UMLS:C4025626	hp.json		http://purl.obolibrary.org/obo/HP_0003345		
HP:0030977	biolink:PhenotypicFeature	Increased factor VIII activity	Increased activity of the coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X.		hp.json	Elevated factor VIII level	http://purl.obolibrary.org/obo/HP_0030977		
HP:0003344	biolink:PhenotypicFeature	3-Methylglutaric aciduria	An abnormally increased level of 3-hydroxy-3-methylglutaric acid in the urine.	UMLS:C3151952	hp.json	3-methylglutaricaciduria	http://purl.obolibrary.org/obo/HP_0003344		
UBERON:0003294	biolink:AnatomicalEntity	gland of foregut	A gland that is part of a foregut [Automatically generated definition].	EMAPA:16557|VHOG:0000650|EHDAA2:0000567|EHDAA:950	hp.json	foregut gland	http://purl.obolibrary.org/obo/UBERON_0003294		
HP:0030978	biolink:PhenotypicFeature	Decreased CSF/serum albumin ratio	A reduction below normal limits of the ratio of the cerebrospinal fluid (CSF) albumin concentration to serum albumin concentration.		hp.json		http://purl.obolibrary.org/obo/HP_0030978		
UBERON:0003295	biolink:AnatomicalEntity	pharyngeal gland	Racemose mucous glands beneath the mucous membrane of the pharynx.	EHDAA2:0001461|EHDAA:2967|FMA:55075|BTO:0004849	hp.json	pharynx gland|glandulae pharyngeae	http://purl.obolibrary.org/obo/UBERON_0003295		organ_slim
HP:0030979	biolink:PhenotypicFeature	Dilatation of large choroidal vessels	Enlargement of the large blood vessels in the choroid.		hp.json	Dilated choroidal vessels	http://purl.obolibrary.org/obo/HP_0030979		
HP:0003343	biolink:PhenotypicFeature	Reduced glutathione synthetase level	Reduced level of the enzyme glutathione synthetase, which catalyzes the last step in the synthesis of glutathione and a deficiency results in low levels of glutathione. Acidosis is due to reduced feedback inhibition of gamma-glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline.	SNOMEDCT_US:124706000|SNOMEDCT_US:39112005|UMLS:C0398746|MSH:C536835|SNOMEDCT_US:234589002	hp.json	Glutathione synthetase deficiency	http://purl.obolibrary.org/obo/HP_0003343		
UBERON:0003292	biolink:AnatomicalEntity	meninx of spinal cord	A meninx that is part of a spinal cord [Automatically generated definition].	MA:0001130|EMAPA:17804|NCIT:C12350|VHOG:0000443|SCTID:181097002|CALOHA:TS-2148|EHDAA:2865|UMLS:C0037938|EHDAA2:0001895	hp.json	menines of spinal cord|spinal meninges|spinal meninx|meninges of spinal cord|spinal cord meninx|spinal cord meninges	http://purl.obolibrary.org/obo/UBERON_0003292		pheno_slim
HP:0030972	biolink:PhenotypicFeature	Abnormal systemic blood pressure	A chronic deviation from normal pressure in the systemic arterial system.		hp.json	Abnormal systemic BP	http://purl.obolibrary.org/obo/HP_0030972		
HP:0003349	biolink:PhenotypicFeature	Low cholesterol esterification rate	A reduction in the rate of cholesterol esterification.	UMLS:C1843371	hp.json		http://purl.obolibrary.org/obo/HP_0003349		
HP:0030973	biolink:PhenotypicFeature	Postexertional symptom exacerbation	Post-exertional symptom exacerbation (PESE), also referred to as post-exertional malaise (PEM), is defined as the worsening of symptoms that can follow minimal cognitive, physical, emotional, or social activity, or activity that could previously be tolerated. Symptoms typically worsen 12 to 72 hours after activity and can last for days or even weeks, sometimes leading to a relapse.		hp.json	Exercise-induced malaise|Postexertional malaise	http://purl.obolibrary.org/obo/HP_0030973		
UBERON:0003290	biolink:AnatomicalEntity	meninx of diencephalon	A meninx that is part of a diencephalon [Automatically generated definition].	MA:0000826|EMAPA:17764|EHDAA:5458|EHDAA2:0000399|VHOG:0000009	hp.json	meninges of mature diencephalon|meninges of diencephalon|meninx of mature diencephalon|mature diencephalon meninx|interbrain meninx|meninx of interbrain|mature diencephalon meninges|interbrain meninges|between brain meninx|meninges of interbrain|between brain meninges|diencephalon meninx|meninges of between brain|diencephalon meninges|meninx of between brain	http://purl.obolibrary.org/obo/UBERON_0003290		
HP:0003348	biolink:PhenotypicFeature	Hyperalaninemia	An increased concentration of alanine in the blood.	UMLS:C1839424|UMLS:C1849489|MSH:C562684|SNOMEDCT_US:2359002|UMLS:C0268630	hp.json	Increased blood alanine|Increased serum alanine	http://purl.obolibrary.org/obo/HP_0003348		
HP:0030974	biolink:PhenotypicFeature	Cryptozoospermia	A type of low sperm count where ejaculated semen contains less than 100,000 spermatozoa per ml. With cryptozoospermia, the sperm count may fluctuate and a zero sperm count in the ejaculate may be initially measured. If sperm are observed in a second semen sample following centrifugation, the diagnosis of cryptozoospermia can be made (and azoospermia can be ruled out).		hp.json	Cryptospermia	http://purl.obolibrary.org/obo/HP_0030974		
UBERON:0003291	biolink:AnatomicalEntity	meninx of hindbrain	A meninx that is part of a hindbrain [Automatically generated definition].	EHDAA2:0000770|MA:0000987|VHOG:0000011|EMAPA:17783|EHDAA:3688	hp.json	rhomencephalon meninges|hindbrain meninx|meninges of hindbrain|hindbrain meninges	http://purl.obolibrary.org/obo/UBERON_0003291		
HP:0003347	biolink:PhenotypicFeature	Impaired lymphocyte transformation with phytohemagglutinin	Normal peripheral blood lymphocytes, when stimulated by phytohemagglutinin (PHA) are cytotoxic for homologous and heterologous cells but not for autologous cells in monolayer culture. The cytotoxic effect is thought to be indicative of the immunological competence of the lymphocytes.	UMLS:C4025625	hp.json		http://purl.obolibrary.org/obo/HP_0003347		
HP:0030975	biolink:PhenotypicFeature	Pontine tegmental cap	An abnormal curved or vaulted (capped) structure covering the middle third of the dorsal pontine tegmentum and projecting into the fourth ventricle.		hp.json	Vaulted pontine tegmentum	http://purl.obolibrary.org/obo/HP_0030975		
CHEBI:22868	biolink:ChemicalSubstance	bile salt			hp.json		http://purl.obolibrary.org/obo/CHEBI_22868		
HP:0003341	biolink:PhenotypicFeature	Lamina lucida cleavage	The formation of bullae (blisters) with cleavage in the lamina lucida layer of the skin.	UMLS:C4021730	hp.json	Junctional split|Blistering with junctional split|Subepidermal blistering with cleavage in the lamina lucida	http://purl.obolibrary.org/obo/HP_0003341		
HP:0003340	biolink:PhenotypicFeature	obsolete Abnormal dermatological laboratory findings			hp.json		http://purl.obolibrary.org/obo/HP_0003340		
UBERON:0003299	biolink:AnatomicalEntity	roof plate of midbrain	The mesencephalic roof plate, including the caudal and rostral part of the midbrain roof.	DHBA:12320|EHDAA2:0001177|VHOG:0000772|EHDAA:3712|ZFA:0000355|RETIRED_EHDAA2:0001111|EMAPA:16981|TAO:0000355	hp.json	roofplate of midbrain|roofplate midbrain|midbrain roof|roof plate midbrain region|roof plate midbrain|midbrain roofplate|midbrain roof plate|roof plate mesencephalon	http://purl.obolibrary.org/obo/UBERON_0003299		pheno_slim|vertebrate_core
HP:0040302	biolink:PhenotypicFeature	Hyperglycerolemia	Increased concentration of glycerol in the blood.		hp.json	Pseudohypertriglyceridemia	http://purl.obolibrary.org/obo/HP_0040302		
HP:0040303	biolink:PhenotypicFeature	Decreased serum iron			hp.json	Low serum iron	http://purl.obolibrary.org/obo/HP_0040303		
HP:0040300	biolink:PhenotypicFeature	Abnormal circulating free fatty acid concentration	Any deviation from the normal concentration of a free fatty acid in the blood circulation.		hp.json	Abnormal circulating free fatty acid level	http://purl.obolibrary.org/obo/HP_0040300		
HP:0040301	biolink:PhenotypicFeature	Increased urinary glycerol	An increased concentration of glycerol in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0040301		
HP:0040306	biolink:PhenotypicFeature	Decreased male libido	Reduced desire for sexual activity on the part of a male.		hp.json		http://purl.obolibrary.org/obo/HP_0040306		
HP:0040307	biolink:PhenotypicFeature	Male sexual dysfunction	A problem occurring during any phase of the male sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity		hp.json		http://purl.obolibrary.org/obo/HP_0040307		
HP:0040304	biolink:PhenotypicFeature	Duplication of the sella turcica			hp.json	Duplicate sella turcica|Duplicated sella turcica	http://purl.obolibrary.org/obo/HP_0040304		
HP:0040305	biolink:PhenotypicFeature	Increased male libido	Increased desire for sexual activity on the part of a male.		hp.json		http://purl.obolibrary.org/obo/HP_0040305		
HP:0030980	biolink:PhenotypicFeature	Reduced brain glutamine level by MRS	An decrease in the level of glutamine in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json		http://purl.obolibrary.org/obo/HP_0030980		
HP:0030981	biolink:PhenotypicFeature	Abnormal CSF/serum albumin ratio	A deviation from the normal range of the ratio of the albumin concentration in the cerebrospinal fluid (CSF) to the concentration in serum (which may be defined as 3.2-9.0). This is an index of blood-brain barrier (BBB) integrity, adjusted for the serum albumin concentration, and an increased ratio is taken as a sign of a loss of integrity of the BBB with leakage of albumin into the CSF.		hp.json		http://purl.obolibrary.org/obo/HP_0030981		
HP:0040308	biolink:PhenotypicFeature	Male anorgasmia	Inability of a male to reach orgasm.		hp.json		http://purl.obolibrary.org/obo/HP_0040308		
HP:0040309	biolink:PhenotypicFeature	Increased size of the mandible			hp.json	Large jaw	http://purl.obolibrary.org/obo/HP_0040309		
HP:0030987	biolink:PhenotypicFeature	Suppurative cholangitis	Cholangitis characterized by the presence of numerous polymorphonuclear cells around and within the wall as well as within the lumen of the ducts. This may involve ducts of any size and is occasionally associated with abscess formation (cholangitic abscess).		hp.json		http://purl.obolibrary.org/obo/HP_0030987		
HP:0003357	biolink:PhenotypicFeature	Thymic hormone decreased	A reduction in the level of thymic horomone.	UMLS:C1857652	hp.json	Decreased thymic hormone	http://purl.obolibrary.org/obo/HP_0003357		
HP:0030988	biolink:PhenotypicFeature	Granulomatous cholangitis	Cholangitis characterized by the accumulation of granulomas. Granulomas are aggregates of modified macrophages (epithelioid cells) and other inflammatory cells that accumulate after chronic exposure to antigens. The underlying trigger may be exposure to noxious agents that cannot be biochemically degraded or to immune dysfunction. The ultimate result is a release of a variety cytokines that stimulate mononuclear cells that fuse to form multinucleated giant cells with a surrounding rim of lymphocytes and fibroblasts.		hp.json		http://purl.obolibrary.org/obo/HP_0030988		
HP:0003355	biolink:PhenotypicFeature	Aminoaciduria	An increased concentration of an amino acid in the urine.	SNOMEDCT_US:35912001|UMLS:C0238621|UMLS:C4020843	hp.json	Hyperaminoaciduria|Increased levels of animo acids in urine|High urine amino acid levels|Abnormal urinary amino-acid findings	http://purl.obolibrary.org/obo/HP_0003355		
HP:0030989	biolink:PhenotypicFeature	Lymphoid cholangitis	Cholangitis characterized by a close association between duct branches, usually interlobular bile ducts, and lymphocytic aggregates, which may show a follicular arrangement.		hp.json		http://purl.obolibrary.org/obo/HP_0030989		
UBERON:0003283	biolink:AnatomicalEntity	mesentery of oesophagus	A mesentery that is part of a esophagus [Automatically generated definition].	VHOG:0000415|EHDAA2:0001288|EMAPA:16836|MA:0001569|EHDAA:2943	hp.json	gullet mesentery|esophagus mesentery|mesentery of esophagus|meso-esophagus|oesophagus mesentery|mesentery of gullet	http://purl.obolibrary.org/obo/UBERON_0003283		
UBERON:0003284	biolink:AnatomicalEntity	mesentery of midgut	A mesentery that is part of a midgut [Automatically generated definition].	EHDAA2:0001202|EMAPA:17197|VHOG:0000413|EHDAA:3031|EMAPA:16721|EMAPA:17039	hp.json	midgut mesentery	http://purl.obolibrary.org/obo/UBERON_0003284		
HP:0003354	biolink:PhenotypicFeature	Hyperthreoninemia	An increased concentration of threonine in the blood.	UMLS:C1848861	hp.json	High blood threonine levels|Elevated circulating threonine	http://purl.obolibrary.org/obo/HP_0003354		
UBERON:0003281	biolink:AnatomicalEntity	mesentery of stomach	The portion of the primitive mesentery that encloses the stomach; from its dorsal sheet, the greater omentum develops, and from its ventral sheet, the lesser omentum.	VHOG:0000358|MA:0001617|EHDAA:2999|EHDAA2:0001922|EMAPA:17024	hp.json	ventriculus mesentery|mesentery of ventriculus|mesogastrium|mesogaster|mesogastium|stomach mesentery	http://purl.obolibrary.org/obo/UBERON_0003281		pheno_slim
HP:0030983	biolink:PhenotypicFeature	Ovarian thecoma	A sex cord-stromal tumor of the ovary. Thecomas range from small tumors to large solid or solid-cystic masses of up to 15 cm. They are unilateral in over 90 percent of cases and are rarely malignant. Thecomas are stromal tumors made up of cells that resemble theca cells, lutein cells and fibroblasts. They are traditionally classified within the sex cord-stromal tumor category of ovarian tumor types.		hp.json		http://purl.obolibrary.org/obo/HP_0030983		
HP:0030984	biolink:PhenotypicFeature	Abnormal serum bile acid concentration	A deviation from the normal concentration of serum bile acid concentration.		hp.json		http://purl.obolibrary.org/obo/HP_0030984		
UBERON:0003282	biolink:AnatomicalEntity	mesentery of heart	A mesentery that surrounds the heart.	VHOG:0000353|EMAPA:16212|EHDAA:432|RETIRED_EHDAA2:0000739	hp.json	cardiac mesentery|heart mesentery|mesocardium	http://purl.obolibrary.org/obo/UBERON_0003282		
HP:0030985	biolink:PhenotypicFeature	Decreased serum bile acid concentration	A reduction in the concentration of bile acid in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0030985		
HP:0003359	biolink:PhenotypicFeature	Decreased urinary sulfate	Decreased concentration of sulfate in the urine.	UMLS:C1848958	hp.json	Decreased urinary sulphate|Decreased urinary sulfate	http://purl.obolibrary.org/obo/HP_0003359		
HP:0030986	biolink:PhenotypicFeature	Biliary epithelial hyperplasia	Hyperplasia of lining epithelia of the septal and large bile ducts manifesting as micropapillary projections or as a stratification of the epithelium with or without dilatation of the duct lumen.		hp.json		http://purl.obolibrary.org/obo/HP_0030986		
HP:0003358	biolink:PhenotypicFeature	Elevated intracellular cystine	An increased concentration of cystine within cells. This finding can be demonstrated on leukocytes, but is not specific to blood cells.	UMLS:C4025623	hp.json		http://purl.obolibrary.org/obo/HP_0003358		
HP:0003353	biolink:PhenotypicFeature	Propionyl-CoA carboxylase deficiency	An abnormality of amino acid metabolism characterized by a decreased level of propionyl-CoA carboxylase.	SNOMEDCT_US:69080001|UMLS:C0268579|MSH:D056693|SNOMEDCT_US:124718009	hp.json		http://purl.obolibrary.org/obo/HP_0003353		
UBERON:0003289	biolink:AnatomicalEntity	meninx of telencephalon	A meninx that is part of a telencephalon [Automatically generated definition].	EHDAA:5476|EHDAA2:0001990|MA:0000979|VHOG:0000010|EMAPA:17774	hp.json	meninges of telencephalon|telencephalon meninx|telencephalon meninges	http://purl.obolibrary.org/obo/UBERON_0003289		
HP:0003352	biolink:PhenotypicFeature	Endopolyploidy on chromosome studies of bone marrow	An increase in the number of chromosome sets per cell in bone marrow cells.	UMLS:C4025624	hp.json		http://purl.obolibrary.org/obo/HP_0003352		
HP:0003351	biolink:PhenotypicFeature	Decreased circulating renin level	An decreased level of renin in the blood.	UMLS:C1845206	hp.json	Decreased plasma renin activity|Low plasma renin activity|Suppressed plasma renin activity	http://purl.obolibrary.org/obo/HP_0003351		
UBERON:0003288	biolink:AnatomicalEntity	meninx of midbrain	A meninx that is part of a midbrain [Automatically generated definition].	MA:0001058|EMAPA:17791|RETIRED_EHDAA2:0001109|EHDAA:3708|EHDAA2:0001174|VHOG:0000012	hp.json	midbrain meninges|meninges of midbrain|midbrain meninx|mesencephalon meninges	http://purl.obolibrary.org/obo/UBERON_0003288		
HP:0040313	biolink:PhenotypicFeature	Oligoarthritis	A type of arthritis that affects up to four joints in the first six months of disease.		hp.json		http://purl.obolibrary.org/obo/HP_0040313		
HP:0040314	biolink:PhenotypicFeature	Blind vagina	The vagina ends in a blind pouch or sac rather than being connected to the internal genitalia.		hp.json	Blind-ended vagina	http://purl.obolibrary.org/obo/HP_0040314		
UBERON:0015251	biolink:AnatomicalEntity	modified sebaceous gland		MA:0003043|EMAPA:37680	hp.json		http://purl.obolibrary.org/obo/UBERON_0015251		
UBERON:0039261	biolink:AnatomicalEntity	pancreatic artery		FMA:70471	hp.json		http://purl.obolibrary.org/obo/UBERON_0039261		
HP:0040311	biolink:PhenotypicFeature	Symmetric polyarthritis	Polyarthritis refers to a joint disease that involves at least five joints. One or more signs of inflammation, including pain, movement restriction, swelling, warmth, and redness, are seen in the joints involved. Polyarthritis is defined as symmetric if at least half of the joints involved are affected in a symmetric (i.e., both right and the left) fashion.		hp.json		http://purl.obolibrary.org/obo/HP_0040311		
HP:0040312	biolink:PhenotypicFeature	Temporomandibular arthritis			hp.json	Arthritis of temporomandibular joint	http://purl.obolibrary.org/obo/HP_0040312		
HP:0040317	biolink:PhenotypicFeature	Blue urine	An abnormal blue color of the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0040317		
HP:0040318	biolink:PhenotypicFeature	Red urine	An abnormal red color of the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0040318		
HP:0040315	biolink:PhenotypicFeature	Tongue edema	An abnormal accumulation of fluid and swelling in the tongue.		hp.json	Tongue oedema	http://purl.obolibrary.org/obo/HP_0040315		
HP:0040316	biolink:PhenotypicFeature	obsolete Aplasia of the penis			hp.json		http://purl.obolibrary.org/obo/HP_0040316		
HP:0030990	biolink:PhenotypicFeature	Pleomorphic cholangitis	Cholangitis associated with mixed inflammatory infiltrates and the presence of fibrosis or sclerosis of the biliary tree.		hp.json		http://purl.obolibrary.org/obo/HP_0030990		
HP:0030991	biolink:PhenotypicFeature	Sclerosing cholangitis	Cholangitis associated with evident ductal fibrosis that develops as a consequence of long-standing bile duct inflammatory, obstruction, or ischemic injury; it can be obliterative or nonobliterative.		hp.json	Fibrous cholangitis	http://purl.obolibrary.org/obo/HP_0030991		
HP:0040319	biolink:PhenotypicFeature	Dark urine	An abnormal dark color of the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0040319		
HP:0030992	biolink:PhenotypicFeature	Abnormal pancreatic duct morphology	Any structural anomaly of the pancreatic duct, which is the tubular structure that collects exocrine pancreatic secretions and transports them to the duodenum.		hp.json		http://purl.obolibrary.org/obo/HP_0030992		
HP:0030993	biolink:PhenotypicFeature	Duplication of pancreatic duct	A congenital anomaly characterized by the presence of two separate pancreatic ducts.		hp.json	Duplicated pancreatic duct	http://purl.obolibrary.org/obo/HP_0030993		
HP:0003329	biolink:PhenotypicFeature	Hair shafts flattened at irregular intervals and twisted through 180 degrees about their axes		UMLS:C4025631	hp.json		http://purl.obolibrary.org/obo/HP_0003329		
HP:0003324	biolink:PhenotypicFeature	Generalized muscle weakness	Generalized weakness or decreased strength of the muscles, affecting both distal and proximal musculature.	UMLS:C0746674	hp.json	Generalized weakness|Muscle weakness, generalized|Muscle weakness, diffuse|Generalised muscle weakness|Muscle weakness, generalised|Generalised weakness	http://purl.obolibrary.org/obo/HP_0003324		
HP:0030998	biolink:PhenotypicFeature	Cerebrospinal fluid rhinorrhoea	Drainage of cerebrospinal fluid through the nose. This can occur when there is a fistula between the dura and the skull base and discharge of cerebrospinal fluid (CSF) from the nose.		hp.json	CSF rhinorrhoea	http://purl.obolibrary.org/obo/HP_0030998		
HP:0005987	biolink:PhenotypicFeature	Multinodular goiter	Enlargement of the thyroid gland related to multiple nodules in the thyroid gland.	UMLS:C0342208|SNOMEDCT_US:237570007	hp.json	Multinodular goitre	http://purl.obolibrary.org/obo/HP_0005987		
HP:0003323	biolink:PhenotypicFeature	Progressive muscle weakness		UMLS:C0240421	hp.json	Muscle weakness, progressive|Progressive muscular weakness	http://purl.obolibrary.org/obo/HP_0003323		
HP:0005988	biolink:PhenotypicFeature	Congenital muscular torticollis	A congenital form of torticollis resulting from shortening of the sternocleidomastoid muscle and leading to a limited range of motion in both rotation and lateral bending.	SNOMEDCT_US:268240006|UMLS:C0079352|MSH:C535425	hp.json	Torticollis, congenital	http://purl.obolibrary.org/obo/HP_0005988		
HP:0030999	biolink:PhenotypicFeature	Abnormal vestibular saccule morphology	Any structural anomaly of the saccule of the vestibule. The saccule is the otolith organ that senses motions in the sagittal plane (i.e., up-down movement).		hp.json		http://purl.obolibrary.org/obo/HP_0030999		
HP:0005989	biolink:PhenotypicFeature	Redundant neck skin	Excess skin around the neck, often lying in horizontal folds.	UMLS:C1840319	hp.json	Excess skin over the neck|Excessive nuchal skin|Redundant nuchal skin|Redundant neck skin|Redundant skin over the neck|Redundant skin folds of neck|Excess neck skin	http://purl.obolibrary.org/obo/HP_0005989		
HP:0003321	biolink:PhenotypicFeature	Biconcave flattened vertebrae		UMLS:C1833753	hp.json		http://purl.obolibrary.org/obo/HP_0003321		
HP:0003328	biolink:PhenotypicFeature	Abnormal hairshaft morphology	An abnormal structure of the hairshaft, i.e., of the nongrowing portion of a hair that protrudes from the skin.	UMLS:C4025632	hp.json		http://purl.obolibrary.org/obo/HP_0003328		
HP:0030994	biolink:PhenotypicFeature	Pancreas divisum	A congenital anomaly of the pancreas that results from failed fusion of the dorsal and ventral ducts during embyological development. Three variants have been described: type 1 or classical divisum in which there is total failure of fusion; type 2 in which dorsal drainage is dominant in the absence of the duct of Wirsung; and type 3 or incomplete divisum where a small communicating branch is present.		hp.json		http://purl.obolibrary.org/obo/HP_0030994		
HP:0030995	biolink:PhenotypicFeature	Peritoneal effusion	An increase in the amount of fluid present in the peritoneal cavity (between the layers of the peritoneum that lines the abdomen).		hp.json		http://purl.obolibrary.org/obo/HP_0030995		
HP:0003327	biolink:PhenotypicFeature	Axial muscle weakness	Reduced strength of the axial musculature (i.e., of the muscles of the head and neck, spine, and ribs).	UMLS:C1843697	hp.json		http://purl.obolibrary.org/obo/HP_0003327		
HP:0005984	biolink:PhenotypicFeature	Elevated maternal serum alpha-fetoprotein	An elevation of alpha-feto protein in the maternal serum.	UMLS:C0740927	hp.json		http://purl.obolibrary.org/obo/HP_0005984		
MPATH:342	biolink:NamedThing	myeloid leukaemia	Leukaemias of the myeloid lineage.	URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2	hp.json	granulocytic leukaemia	http://purl.obolibrary.org/obo/MPATH_342		
HP:0030996	biolink:PhenotypicFeature	Megaduodenum	Dilation and elongation of the duodenum with hypertrophy of all layers of the duodenum.		hp.json		http://purl.obolibrary.org/obo/HP_0030996		
HP:0003326	biolink:PhenotypicFeature	Myalgia	Pain in muscle.	SNOMEDCT_US:68962001|UMLS:C0231528|MSH:D063806	hp.json	Myalgias|Muscle pain|Muscle ache	http://purl.obolibrary.org/obo/HP_0003326		
HP:0030997	biolink:PhenotypicFeature	Atretic vas deferens	Abnormal closure or blockage of the vas deferens.		hp.json	Vas deferens atresia|Atresia of the vas deferens	http://purl.obolibrary.org/obo/HP_0030997		
HP:0003325	biolink:PhenotypicFeature	Limb-girdle muscle weakness	Weakness of the limb-girdle muscles (also known as the pelvic and shoulder girdles), that is, lack of strength of the muscles around the shoulders and the pelvis.	UMLS:C1858127	hp.json	Muscle weakness, limb-girdle|Muscular weakness, limb-girdle|Limb girdle weakness	http://purl.obolibrary.org/obo/HP_0003325		
HP:0005986	biolink:PhenotypicFeature	Limitation of neck motion		UMLS:C0151315|SNOMEDCT_US:405947006|SNOMEDCT_US:161882006|UMLS:C1847392|MSH:D009127|UMLS:C1320474	hp.json	Limited neck mobility|Limitation of neck motion|Restricted neck movement	http://purl.obolibrary.org/obo/HP_0005986		
MPATH:346	biolink:NamedThing	autoimmune mediated disease			hp.json		http://purl.obolibrary.org/obo/MPATH_346		
HP:0005982	biolink:PhenotypicFeature	Reduced phenylalanine hydroxylase level	A reduction in phenylalanine 4-monooxygenase level.	UMLS:C4025094|SNOMEDCT_US:7573000|MSH:D010661|UMLS:C0751434	hp.json	Phenylalanine hydroxylase deficiency	http://purl.obolibrary.org/obo/HP_0005982		
HP:0003320	biolink:PhenotypicFeature	C1-C2 subluxation	A partial dislocation of the atlantoaxial joints.	UMLS:C1848446	hp.json		http://purl.obolibrary.org/obo/HP_0003320		
UBERON:0003278	biolink:AnatomicalEntity	skeleton of lower jaw	A subdivision of the skeleton that corresponds to the lower part of the mouth. The lower jaw skeleton includes the following elements, when present: lower jaw teeth, the mandible and other lower jaw bones, and Meckel's cartilage.	VHOG:0000428|EMAPA:17906|MA:0001906|ZFA:0001273|EHDAA:8005|TAO:0001273|XAO:0003084|AAO:0000274|FMA:54398|EMAPA:17910|EHDAA2:0004606	hp.json	mandible|lower jaw skeleton|mandibles|mandibular series|lower jaw|lower jaw	http://purl.obolibrary.org/obo/UBERON_0003278		pheno_slim
CHEBI:46818	biolink:ChemicalSubstance	urate anion	An organic anion obtained by removal of at least one proton from any uric acid.		hp.json	urate anion	http://purl.obolibrary.org/obo/CHEBI_46818		3_STAR
UBERON:0003279	biolink:AnatomicalEntity	endothelium of trachea	An endothelium that is part of a trachea.	RETIRED_EHDAA2:0002068|EHDAA:3082	hp.json	windpipe endothelium|trachea endothelium|endothelium of windpipe	http://purl.obolibrary.org/obo/UBERON_0003279		
HP:0040310	biolink:PhenotypicFeature	Sterile arthritis	An inflammatory arthritis characterized by purulent synovial fluid with neutrophil accumulation, but with negative cultures.		hp.json		http://purl.obolibrary.org/obo/HP_0040310		
CHEBI:46819	biolink:ChemicalSubstance	urate salt			hp.json		http://purl.obolibrary.org/obo/CHEBI_46819		1_STAR
UBERON:0003277	biolink:AnatomicalEntity	skeleton of upper jaw	A subdivision of the skeleton that corresponds to the upper part of the mouth. The lower jaw skeleton includes the following elements, when present: upper jaw teeth, the maxilla and other lower jaw bones.	EHDAA2:0002128|VHOG:0000429|AAO:0000622|MA:0001908|XAO:0003087|EMAPA:17927|FMA:54397|EHDAA:8041	hp.json	upper jaw|upper jaw skeleton	http://purl.obolibrary.org/obo/UBERON_0003277		pheno_slim
HP:0040324	biolink:PhenotypicFeature	Heliotrope rash	In a heliotrope rash, the color of the skin turns to violet, which is the color of the heliotrope flower.		hp.json	Heliotrope erythema	http://purl.obolibrary.org/obo/HP_0040324		
HP:0040325	biolink:PhenotypicFeature	Bull's eye rash	A cutaneous eruption that consists of multiple (at least two) concentric erythematous rings.		hp.json		http://purl.obolibrary.org/obo/HP_0040325		
HP:0040322	biolink:PhenotypicFeature	Purple urine	An abnormal purple color of the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0040322		
HP:0040323	biolink:PhenotypicFeature	Erythema of the eyelids	Redness of the skin of the eyelids, caused by hyperemia of the capillaries in the lower layers of the skin.		hp.json	Erythema of eyelid|Eyelid erythema	http://purl.obolibrary.org/obo/HP_0040323		
HP:0040328	biolink:PhenotypicFeature	Focal hyperintensity of cerebral white matter on MRI	An abnormal area of increased brightness (hyperintensity) that is limited to one particular area.		hp.json		http://purl.obolibrary.org/obo/HP_0040328		
HP:0040329	biolink:PhenotypicFeature	Multifocal hyperintensity of cerebral white matter on MRI	An abnormal area of increased brightness (hyperintensity) that occurs in several distinct areas.		hp.json		http://purl.obolibrary.org/obo/HP_0040329		
HP:0040326	biolink:PhenotypicFeature	Hypoplasia of the olfactory bulb	Underdevelopment of the olfactory bulb.		hp.json	Hypoplastic olfactory bulb|Hypoplasia of olfactory bulb	http://purl.obolibrary.org/obo/HP_0040326		
HP:0040327	biolink:PhenotypicFeature	Abnormal morphology of the olfactory bulb	An abnormal morphology of the olfactory bulb (bulbus olfactorius), which is involved in olfaction, i.e. the sense of smell.		hp.json		http://purl.obolibrary.org/obo/HP_0040327		
UBERON:0015249	biolink:AnatomicalEntity	digit skin	A zone of skin that is part of a digit [Automatically generated definition].	EMAPA:32615|MA:0003011	hp.json		http://purl.obolibrary.org/obo/UBERON_0015249		pheno_slim
HP:0003335	biolink:PhenotypicFeature	obsolete Low gonadotropins (secondary hypogonadism)			hp.json		http://purl.obolibrary.org/obo/HP_0003335		
HP:0003334	biolink:PhenotypicFeature	Elevated circulating catecholamine level	An abnormal increase in catecholamine concentration in the blood.	UMLS:C4025629	hp.json		http://purl.obolibrary.org/obo/HP_0003334		
HP:0005999	biolink:PhenotypicFeature	Ureteral atresia	A developmental defect defined by the failure of the formation of the lumen (tube) of the ureter.	UMLS:C0266320|SNOMEDCT_US:204974003|SNOMEDCT_US:49534003	hp.json		http://purl.obolibrary.org/obo/HP_0005999		
HP:0003333	biolink:PhenotypicFeature	Increased serum beta-hexosaminidase		UMLS:C2673361	hp.json		http://purl.obolibrary.org/obo/HP_0003333		
UBERON:0003261	biolink:AnatomicalEntity	thyroid primordium endoderm	An endoderm that is part of a thyroid primordium.	EMAPA:25357|EHDAA:956|VHOG:0001089|RETIRED_EHDAA2:0002035	hp.json	endoderm of thyroid primordium	http://purl.obolibrary.org/obo/UBERON_0003261		
UBERON:0003262	biolink:AnatomicalEntity	amniotic mesoderm	A mesenchyme that is part of a amnion.	EMAPA:16265|EMAPA:16111|VHOG:0000622|EHDAA:140|EHDAA2:0000118	hp.json	mesenchyme of amnion|amnion mesoderm|amnionic mesenchyme|amnionic mesoderm|amnion mesenchyme|amnionic mesoderm	http://purl.obolibrary.org/obo/UBERON_0003262		
HP:0003332	biolink:PhenotypicFeature	Absent primary metaphyseal spongiosa		UMLS:C3277126	hp.json		http://purl.obolibrary.org/obo/HP_0003332		
HP:0005994	biolink:PhenotypicFeature	Nodular goiter	Enlargement of the thyroid gland related to one or more nodules in the thyroid gland.	UMLS:C0018023|SNOMEDCT_US:419153005|MSH:D006044	hp.json	Nodular goitre	http://purl.obolibrary.org/obo/HP_0005994		
HP:0003339	biolink:PhenotypicFeature	Pyrimidine-responsive megaloblastic anemia	A type of megaloblastic anemia that improves upon administration of pyrimidine supplements such as uridylic acid and cytidylic acid.	UMLS:C4021731	hp.json	Anemia corrected by uridylic acid and cytidylic acid|Anaemia corrected by uridylic acid and cytidylic acid|Pyrimidine-responsive megaloblastic anaemia	http://purl.obolibrary.org/obo/HP_0003339		
HP:0005995	biolink:PhenotypicFeature	Decreased adipose tissue around neck	Reduced amount of adipose tissue in the region of the neck.	UMLS:C1837763	hp.json	Loss of fat around neck|Loss of adipose tissue around the neck	http://purl.obolibrary.org/obo/HP_0005995		
HP:0003338	biolink:PhenotypicFeature	Focal necrosis of right ventricular muscle cells		UMLS:C4025627	hp.json		http://purl.obolibrary.org/obo/HP_0003338		
UBERON:0003260	biolink:AnatomicalEntity	endoderm of hindgut	An endoderm that is part of a hindgut [Automatically generated definition].	EHDAA:979|RETIRED_EHDAA2:0000781	hp.json	hindgut endoderm	http://purl.obolibrary.org/obo/UBERON_0003260		
HP:0003337	biolink:PhenotypicFeature	Reduced prothrombin consumption	The prothrombin consumption test measures the formation of intrinsic thromboplastin by determining the residual serum prothrombin after blood clotting is complete. If there is a defect in the process, less prothrombin will be converted to thrombin than normal (less prothrombin is consumed). This test may be abnormal with conditions including deficiency of factors VIII or IX, with circulating anticoagulants, thrombocytopenia.	UMLS:C4021732	hp.json	Poor prothrombin consumption	http://purl.obolibrary.org/obo/HP_0003337		
HP:0005997	biolink:PhenotypicFeature	Neck joint contracture		UMLS:C1867006	hp.json	Restricted neck movement due to contractures|Restricted neck mobility due to contractures|Neck joint contracture	http://purl.obolibrary.org/obo/HP_0005997		
HP:0003336	biolink:PhenotypicFeature	Abnormal enchondral ossification	An abnormality of the process of endochondral ossification, which is a type of replacement ossification in which bone tissue replaces cartilage.	UMLS:C4025628	hp.json		http://purl.obolibrary.org/obo/HP_0003336		
HP:0005990	biolink:PhenotypicFeature	Thyroid hypoplasia	Developmental hypoplasia of the thyroid gland.	MSH:D050033|SNOMEDCT_US:367524008|UMLS:C0151516	hp.json	Hypoplastic thyroid|Small thyroid gland	http://purl.obolibrary.org/obo/HP_0005990		
HP:0005991	biolink:PhenotypicFeature	Limited neck flexion	Reduced abilty to lower the chin towards the chest by bending the neck.	UMLS:C1864449	hp.json	Limited cervical flexion|Limited neck flexibility	http://purl.obolibrary.org/obo/HP_0005991		
MPATH:335	biolink:NamedThing	hematopoietic/lymphoid malignancies/disorder	Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages.		hp.json		http://purl.obolibrary.org/obo/MPATH_335		
UBERON:0003269	biolink:AnatomicalEntity	skeletal muscle tissue of eye	A portion of skeletal muscle tissue that is part of a eye [Automatically generated definition].	EHDAA2:0000486|EMAPA:17844|EHDAA:2923	hp.json	eye skeletal muscle tissue|eye skeletal muscle group|skeletal muscle tissue of eye|eye skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0003269		
HP:0040320	biolink:PhenotypicFeature	Red-brown urine	An abnormal red-brown color of the urine.		hp.json	red brown urine	http://purl.obolibrary.org/obo/HP_0040320		
UBERON:0003267	biolink:AnatomicalEntity	tooth of upper jaw	A calcareous tooth that is part of the upper jaw region. In mammals, the upper jaw teeth are attached to the maxilla.	MA:0001909|UMLS:C1710581|EMAPA:17938|NCIT:C49792|EHDAA:8045	hp.json	upper jaw tooth|maxillary tooth	http://purl.obolibrary.org/obo/UBERON_0003267		
UBERON:0003268	biolink:AnatomicalEntity	tooth of lower jaw	A calcareous tooth that is part of the lower jaw region. In mammals, the lower jaw teeth are attached to the mandible (dentary).	EHDAA2:0001029|UMLS:C1708757|EHDAA:8009|EMAPA:17917|MA:0001907|FMA:321647|NCIT:C49582	hp.json	mandibular tooth|lower jaw dentine containing tooth|lower jaw tooth|lower jaw vertebrate tooth|lower jaw calcareous tooth|calcareous tooth of lower jaw	http://purl.obolibrary.org/obo/UBERON_0003268		
HP:0040321	biolink:PhenotypicFeature	Dark yellow urine	An abnormal dark-yellow color of the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0040321		
HP:0003330	biolink:PhenotypicFeature	Abnormal bone structure	Any anomaly in the composite material or the layered arrangement of the bony skeleton.	UMLS:C4025630	hp.json		http://purl.obolibrary.org/obo/HP_0003330		
UBERON:0003265	biolink:AnatomicalEntity	chorionic mesenchyme	A mesenchyme that is part of a chorion.	EMAPA:16266|EHDAA:154|EHDAA2:0003245|VHOG:0000620|RETIRED_EHDAA2:0000247|EMAPA:16114	hp.json	chorion mesoderm|mesenchyme of chorion|mesenchyme of chorion (vertebrates)|chorion mesenchyme|chorionic mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003265		
CHEBI:83813	biolink:ChemicalSubstance	proteinogenic amino acid	Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration.	Wikipedia:Proteinogenic_amino_acid	hp.json	proteinogenic amino acids|canonical amino acid|canonical amino acids	http://purl.obolibrary.org/obo/CHEBI_83813		3_STAR
CHEBI:83812	biolink:ChemicalSubstance	non-proteinogenic amino acid derivative	Any derivative of a non-proteinogenic amino acid resulting from reaction at an amino group or carboxy group, or from the replacement of any hydrogen by a heteroatom.		hp.json	non-canonical amino-acid derivatives|non-canonical amino acid derivative|non-proteinogenic amino-acid derivatives	http://purl.obolibrary.org/obo/CHEBI_83812		3_STAR
CHEBI:83811	biolink:ChemicalSubstance	proteinogenic amino acid derivative	Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom.		hp.json	canonical amino-acid derivatives|canonical amino-acid derivative|proteinogenic amino acid derivatives|canonical amino acid derivative|proteinogenic amino-acid derivatives|proteinogenic amino-acid derivative|canonical amino acid derivatives	http://purl.obolibrary.org/obo/CHEBI_83811		3_STAR
HP:0030932	biolink:PhenotypicFeature	1-minute APGAR score of 5			hp.json		http://purl.obolibrary.org/obo/HP_0030932		
HP:0030933	biolink:PhenotypicFeature	1-minute APGAR score of 6			hp.json		http://purl.obolibrary.org/obo/HP_0030933		
HP:0030934	biolink:PhenotypicFeature	Oral erythroplakia	A velvety red but not ulcerated lesion of the oral mucosa. The texture may be roughened or normal, and the lesion is neither raised nor depressed.		hp.json	Oral erythroplasia	http://purl.obolibrary.org/obo/HP_0030934		
HP:0003388	biolink:PhenotypicFeature	Easy fatigability	Increased susceptibility to fatigue.	SNOMEDCT_US:248268002|UMLS:C1837098|UMLS:C0424585	hp.json	Tired easily	http://purl.obolibrary.org/obo/HP_0003388		
HP:0003387	biolink:PhenotypicFeature	Decreased number of large peripheral myelinated nerve fibers	A reduced number of large myelinated nerve fibers.	UMLS:C1859606	hp.json	Depletion of large myelinated fibres|Loss of large myelinated fibers|Decreased number of large peripheral myelinated nerve fibres|Loss of large myelinated fibres|Loss of larger myelinated nerve fibers|Depletion of large myelinated fibers|Loss of larger myelinated nerve fibres	http://purl.obolibrary.org/obo/HP_0003387		
HP:0030935	biolink:PhenotypicFeature	Abnormality of intestinal smooth muscle morphology	A structural anomaly of the nonstriated, involuntary muscle tissue of the intestine.		hp.json		http://purl.obolibrary.org/obo/HP_0030935		
HP:0030930	biolink:PhenotypicFeature	1-minute APGAR score of 3			hp.json		http://purl.obolibrary.org/obo/HP_0030930		
HP:0030931	biolink:PhenotypicFeature	1-minute APGAR score of 4			hp.json		http://purl.obolibrary.org/obo/HP_0030931		
MPATH:322	biolink:NamedThing	teratoma	Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1).		hp.json		http://purl.obolibrary.org/obo/MPATH_322		
HP:0003382	biolink:PhenotypicFeature	Hypertrophic nerve changes		UMLS:C1832776	hp.json		http://purl.obolibrary.org/obo/HP_0003382		
HP:0003380	biolink:PhenotypicFeature	Decreased number of peripheral myelinated nerve fibers	A loss of myelinated nerve fibers in the peripheral nervous system (in general, this finding can be observed on nerve biopsy).	UMLS:C1858285	hp.json	Loss of myelinated fibres|Decreased number of large and small myelinated fibers|Decreased number of peripheral myelinated nerve fibres|Decreased number of large and small myelinated fibres|Loss of myelinated fibers	http://purl.obolibrary.org/obo/HP_0003380		
HP:0030936	biolink:PhenotypicFeature	Abnormal layering of muscularis propria	Abnormal layering of the intestinal muscularis propria into three layers; (1) inner circular; (2) additional oblique; and (3) outer longitudinal layer.		hp.json	Segmental additional circular muscle coat|Muscularis propria malformation	http://purl.obolibrary.org/obo/HP_0030936		
HP:0030937	biolink:PhenotypicFeature	Fibrotic muscularis propria	The presence of excessive fibrous connective tissue in the muscularis propria of the intestine. Fibrosis is a reparative or reactive process.		hp.json		http://purl.obolibrary.org/obo/HP_0030937		
HP:0030938	biolink:PhenotypicFeature	Enteric intraneuronal nuclear inclusion bodies	Aggregates of stainable substances (proteins) in the nuclei of enteric neurons.		hp.json		http://purl.obolibrary.org/obo/HP_0030938		
HP:0003384	biolink:PhenotypicFeature	Peripheral axonal atrophy	Atrophic changes of axons of the peripheral nervous system.	UMLS:C4025619	hp.json		http://purl.obolibrary.org/obo/HP_0003384		
HP:0030939	biolink:PhenotypicFeature	Palpebral thickening	An increased thickness of the eyelid not related to acute inflammation.		hp.json	Eyelid thickening|Thickened eyelid|Thickened but nonswollen eyelids|Thick eyelids	http://purl.obolibrary.org/obo/HP_0030939		
HP:0003383	biolink:PhenotypicFeature	Onion bulb formation	Repeated episodes of segmental demyelination and remyelination lead to the accumulation of supernumerary Schwann cells around axons, which is referred to as onion bulb formation. This finding affects peripheral nerves.	UMLS:C1847906	hp.json	Onion bulb formations	http://purl.obolibrary.org/obo/HP_0003383		
CHEBI:83822	biolink:ChemicalSubstance	non-proteinogenic L-alpha-amino acid	Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.		hp.json	non-proteinogenic L-alpha-amino acids	http://purl.obolibrary.org/obo/CHEBI_83822		3_STAR
CHEBI:83821	biolink:ChemicalSubstance	amino acid derivative	Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues.		hp.json	modified amino acids|amino acid derivatives	http://purl.obolibrary.org/obo/CHEBI_83821		3_STAR
CHEBI:83820	biolink:ChemicalSubstance	non-proteinogenic amino acid	Any amino-acid that is not naturally encoded in the genetic code of any organism.	Wikipedia:Non-proteinogenic_amino_acids	hp.json	non-proteinogenic amino-acid|non-coded amino-acids|non-canonical amino-acids|non-canonical amino acid|non-coded amino acids|non-coded amino acid|non-canonical amino acids|non-canonical amino-acid|non-coded amino-acid|non-proteinogenic amino-acids|non-proteinogenic amino acids	http://purl.obolibrary.org/obo/CHEBI_83820		3_STAR
HP:0030943	biolink:PhenotypicFeature	Vulvodynia	Pain in the vulvar area		hp.json	Vulvar pain	http://purl.obolibrary.org/obo/HP_0030943		
HP:0030946	biolink:PhenotypicFeature	Conjunctival papillae	Raised tissue masses located on the palpebral conjunctiva with a central vessel. Papillae are created by a focal infiltration of inflammatory cells.		hp.json		http://purl.obolibrary.org/obo/HP_0030946		
HP:0003398	biolink:PhenotypicFeature	Abnormal synaptic transmission at the neuromuscular junction	Any abnormality of the neuromuscular junction, which is the synapse between the motor end plate of a motor neuron and the skeletal muscle fibers.	UMLS:C4025618|UMLS:C4020842	hp.json	Abnormality of neuromuscular transmission	http://purl.obolibrary.org/obo/HP_0003398		
MPATH:310	biolink:NamedThing	germ cell tumor	Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells.		hp.json		http://purl.obolibrary.org/obo/MPATH_310		
HP:0003393	biolink:PhenotypicFeature	Thenar muscle atrophy	Wasting of thenar muscles, which are located on palm of the hand at the base of the thumb.	UMLS:C1864715	hp.json	Thenar atrophy	http://purl.obolibrary.org/obo/HP_0003393		
HP:0003392	biolink:PhenotypicFeature	First dorsal interossei muscle weakness		UMLS:C1832277	hp.json		http://purl.obolibrary.org/obo/HP_0003392		
HP:0003391	biolink:PhenotypicFeature	Gowers sign	A phenomenon whereby patients are not able to stand up without the use of the hands owing to weakness of the proximal muscles of the lower limbs.	SNOMEDCT_US:298294005|UMLS:C0234182|UMLS:C0575071|SNOMEDCT_US:85905009	hp.json	Positive Gower sign|Gower sign|Positive Gowers sign	http://purl.obolibrary.org/obo/HP_0003391		
HP:0003390	biolink:PhenotypicFeature	Sensory axonal neuropathy	An axonal neuropathy of peripheral sensory nerves.	UMLS:C1842587|UMLS:C1970883	hp.json	Axonal sensory neuropathy|Peripheral sensory axonal neuropathy	http://purl.obolibrary.org/obo/HP_0003390		
HP:0030947	biolink:PhenotypicFeature	Conjunctival follicles	Small, dome-shaped nodules without a prominent central vessel located on the conjunctiva. The lymphoid follicles are located in the subendothelial region of the conjunctiva. They consist of a germinal center that contains immature, proliferating lymphocytes, as well as a corona that contains mature lymphocytes and plasma cells.		hp.json		http://purl.obolibrary.org/obo/HP_0030947		
HP:0003397	biolink:PhenotypicFeature	Generalized hypotonia due to defect at the neuromuscular junction		UMLS:C1853950	hp.json	Generalised hypotonia due to defect at the neuromuscular junction	http://purl.obolibrary.org/obo/HP_0003397		
HP:0003396	biolink:PhenotypicFeature	Syringomyelia	Dilated, glial-lined cavity in spinal cord. This cavity does not communicate with the central canal, and usually is between the dorsal columns unilaterally or bilaterally along the side of the cord.	MSH:D013595|UMLS:C0039144|SNOMEDCT_US:111496009	hp.json	Fluid-filled cyst in spinal cord|Syrinx	http://purl.obolibrary.org/obo/HP_0003396		
HP:0030948	biolink:PhenotypicFeature	Elevated gamma-glutamyltransferase level	Increased level of the enzyme gamma-glutamyltransferase (GGT). GGT is mainly present in kidney, liver, and pancreatic cells, but small amounts are present in other tissues.		hp.json	Elevated serum GGT	http://purl.obolibrary.org/obo/HP_0030948		
HP:0030949	biolink:PhenotypicFeature	Glomerular deposits	An abnormal accumulation of protein in the glomerulus.		hp.json		http://purl.obolibrary.org/obo/HP_0030949		
HP:0003394	biolink:PhenotypicFeature	Muscle spasm	Sudden and involuntary contractions of one or more muscles.	UMLS:C0026821|SNOMEDCT_US:55300003|MSH:D009120	hp.json	Muscle cramps	http://purl.obolibrary.org/obo/HP_0003394		
NBO:0001845	biolink:NamedThing	consumption behavior	"Behavior related to the intake of substances." [NBOC:GVG]		hp.json	ingest	http://purl.obolibrary.org/obo/NBO_0001845		
UBERON:0039222	biolink:AnatomicalEntity	cystic artery	An artery that supplies oxygenated blood to the cystic duct.	FMA:14835	hp.json	cholecystic artery	http://purl.obolibrary.org/obo/UBERON_0039222		
NCBITaxon:9604	biolink:OrganismalEntity	Hominidae			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_9604		
NCBITaxon:9605	biolink:OrganismalEntity	Homo			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_9605		
NCBITaxon:9606	biolink:OrganismalEntity	Homo sapiens			hp.json	human|h	http://purl.obolibrary.org/obo/NCBITaxon_9606		
UBERON:0039228	biolink:AnatomicalEntity	sigmoid vein		FMA:15395	hp.json		http://purl.obolibrary.org/obo/UBERON_0039228		
HP:0003368	biolink:PhenotypicFeature	Abnormal femoral head morphology	An abnormality of the femoral head.	UMLS:C4025620	hp.json	Abnormality of the femoral head|Abnormal head of thigh bone	http://purl.obolibrary.org/obo/HP_0003368		
HP:0030955	biolink:PhenotypicFeature	Alcoholism	An addictive behavior defined as drinking excessive amounts of alcohol over a long period of time, having difficulty reducing the amount of alcohol consumed, strongly desiring alcohol and experiencing withdrawal symptoms when not drinking alcohol.		hp.json		http://purl.obolibrary.org/obo/HP_0030955		
HP:0003367	biolink:PhenotypicFeature	Abnormal femoral neck morphology	An abnormality of the femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft).	UMLS:C4025621	hp.json	Abnormality of the femoral neck|Abnormal neck of thigh bone	http://purl.obolibrary.org/obo/HP_0003367		
HP:0030956	biolink:PhenotypicFeature	Abnormality of cardiovascular system electrophysiology	An anomaly of the electrical conduction physiology of the heart.		hp.json		http://purl.obolibrary.org/obo/HP_0030956		
HP:0003366	biolink:PhenotypicFeature	Abnormal femoral neck/head morphology		UMLS:C4025622	hp.json	Abnormality of the femoral neck or head region|Abnormal neck or head of thigh bone	http://purl.obolibrary.org/obo/HP_0003366		
HP:0030957	biolink:PhenotypicFeature	Ventricular septal aneurysm	A bowing (bulging to one side) of the interventricular septum of more than 15 mm on either side in adults and 5 mm in children during normal cardiac motion.		hp.json	Ventricular septal dilatation	http://purl.obolibrary.org/obo/HP_0030957		
HP:0003365	biolink:PhenotypicFeature	Arthralgia of the hip	Joint pain affecting the hip.	UMLS:C0019559|SNOMEDCT_US:49218002	hp.json	Coxalgia|Hip arthralgia|Hip joint pain	http://purl.obolibrary.org/obo/HP_0003365		
HP:0030950	biolink:PhenotypicFeature	Pulmonary venous hypertension	An abnormal increase in pressure in the pulmonary veins, usually as a result of left atrial hypertension.		hp.json		http://purl.obolibrary.org/obo/HP_0030950		
HP:0030951	biolink:PhenotypicFeature	Skeletal muscle fibrosis	Excessive formation of fibrous bands of scar tissue in between muscle fibers.		hp.json		http://purl.obolibrary.org/obo/HP_0030951		
HP:0030952	biolink:PhenotypicFeature	Birdshot retinochoroidopathy	Multiple cream-yellow colored hypopigmented lesions typically located at the level of the choroid or retinal pigment epithelium; ovoid, cream-colored with indistinct borders. They are between 50 and 1,500 micrometers in size with a characteristic nasal, radial distribution in the postequatorial fundus.		hp.json	Birdshot laesions|Birdshot lesions|Birdshot choroidal lesions	http://purl.obolibrary.org/obo/HP_0030952		
HP:0030953	biolink:PhenotypicFeature	Conjunctival hyperemia	Dilatation of the blood vessels of the conjunctiva leading to a red appearance of the sclera.		hp.json	Conjunctival injection|Conjunctival vascular congestion|Conjunctival hyperaemia	http://purl.obolibrary.org/obo/HP_0030953		
HP:0030958	biolink:PhenotypicFeature	Membranous ventricular septal aneurysm	Bowing (bulging out) of the membranous part of the interventricular septum of more than 10-15 mm into the cavity of an adjacent ventricle (usually into the right ventricle).	Fyler:2346	hp.json	Aneurysm of the membranous ventricular septum|Interventricular septum membranous part aneurysm	http://purl.obolibrary.org/obo/HP_0030958		
HP:0003363	biolink:PhenotypicFeature	Abdominal situs inversus	A left-right reversal (or "mirror reflection") of the anatomical location of the viscera of the abdomen.	Fyler:3816|SNOMEDCT_US:27317008|MSH:D012857|SNOMEDCT_US:43876007|UMLS:C0037221	hp.json	Situs inversus viscerum|Situs inversus visceralis	http://purl.obolibrary.org/obo/HP_0003363		
HP:0030959	biolink:PhenotypicFeature	Muscular ventricular septal aneurysm	Bowing (bulging out) of the muscular part of the interventricular septum of more than 10-15 mm into the cavity of an adjacent ventricle (usually into the right ventricle).		hp.json	Aneurysm of the muscular ventricular septum	http://purl.obolibrary.org/obo/HP_0030959		
MPATH:309	biolink:NamedThing	gonadal tumor	Germ cell and non-germ cell tumors of the testis and ovary.		hp.json		http://purl.obolibrary.org/obo/MPATH_309		
HP:0003362	biolink:PhenotypicFeature	Increased VLDL cholesterol concentration	An increase in the amount of very-low-density lipoprotein cholesterol in the blood.	UMLS:C4021729	hp.json	Increased circulating very-low-density lipoprotein cholesterol|Increased plasma VLDL cholesterol|Increased circulating very-low-density lipoprotein levels	http://purl.obolibrary.org/obo/HP_0003362		
HP:0003361	biolink:PhenotypicFeature	Tryptophanuria	An increased concentration of tryptophan in the urine.	SNOMEDCT_US:18789002|UMLS:C0268472	hp.json	High urine tryptophan levels	http://purl.obolibrary.org/obo/HP_0003361		
UBERON:0015281	biolink:AnatomicalEntity	pancreas right lobe	A pancreatic lobule that is in_the_right_side_of a exocrine pancreas.	MA:0000723|EMAPA:37712	hp.json		http://purl.obolibrary.org/obo/UBERON_0015281		
UBERON:0015280	biolink:AnatomicalEntity	pancreas left lobe	A pancreatic lobule that is in_the_left_side_of a exocrine pancreas.	MA:0000722|EMAPA:37711	hp.json		http://purl.obolibrary.org/obo/UBERON_0015280		
HP:0030960	biolink:PhenotypicFeature	obsolete Abnormal pupillary morphology			hp.json		http://purl.obolibrary.org/obo/HP_0030960		
HP:0030965	biolink:PhenotypicFeature	Aortic stiffness	The elastic properties of the aorta allow the aorta to store half of the cardiac ejected blood volume per beat, whereby aortic recoil during diastole pushes the remaining stored volume forward into the peripheral circulation, a phenomenon known as the Windkessel function. Aortic stiffness occurs as the elastic fibers within the arterial wall become disrupted due to mechanical stress (with age or due to other factors). Aortic stiffness refers to a reduction in the elasticity of the aorta, which is associated with an elevated pulse pressure, increased wave reflection, and often hypertension.		hp.json	Increased aortic stiffness	http://purl.obolibrary.org/obo/HP_0030965		
HP:0030966	biolink:PhenotypicFeature	Abnormal pulmonary artery morphology	An abnormality of the structure of the pulmonary artery.		hp.json		http://purl.obolibrary.org/obo/HP_0030966		
HP:0003378	biolink:PhenotypicFeature	Axonal degeneration/regeneration	A pattern of simultaneous degeneration and regeneration of axons (see comment).	UMLS:C1968790	hp.json	Axon degeneration and regeneration	http://purl.obolibrary.org/obo/HP_0003378		
HP:0030967	biolink:PhenotypicFeature	Abnormal pulmonary artery physiology	An abnormality of the function of the pulmonary artery.		hp.json		http://purl.obolibrary.org/obo/HP_0030967		
HP:0003376	biolink:PhenotypicFeature	Steppage gait	An abnormal gait pattern that arises from weakness of the pretibial and peroneal muscles due to a lower motor neuron lesion. Affected patients have footdrop and are unable to dorsiflex and evert the foot. The leg is lifted high on walking so that the toes clear the ground, and there may be a slapping noise when the foot strikes the ground again.	MSH:D020233|UMLS:C0427149|SNOMEDCT_US:27253007	hp.json	High stepping	http://purl.obolibrary.org/obo/HP_0003376		
HP:0030968	biolink:PhenotypicFeature	Abnormal pulmonary vein morphology	An abnormality of the structure of the pulmonary veins.	Fyler:3000	hp.json		http://purl.obolibrary.org/obo/HP_0030968		
HP:0030961	biolink:PhenotypicFeature	Microspherophakia	Lens of the eye is smaller than normal and spherically shaped.		hp.json		http://purl.obolibrary.org/obo/HP_0030961		
HP:0030962	biolink:PhenotypicFeature	Abnormal morphology of the great vessels	A structural anomaly affecting a blood vessel involved in the circulation of the heart, i.e., the superior or inferior vena cava, the pulmonary arteries, the pulmonary veins, and the aorta.		hp.json		http://purl.obolibrary.org/obo/HP_0030962		
HP:0030963	biolink:PhenotypicFeature	obsolete Abnormal aortic morphology			hp.json		http://purl.obolibrary.org/obo/HP_0030963		
HP:0030964	biolink:PhenotypicFeature	Abnormal aortic physiology			hp.json		http://purl.obolibrary.org/obo/HP_0030964		
HP:0003371	biolink:PhenotypicFeature	Enlargement of the proximal femoral epiphysis	An abnormal enlargement of the proximal epiphysis of the femur.	UMLS:C1859697	hp.json	Enlarged end part of innermost thighbone|Enlarged capital femoral epiphyses	http://purl.obolibrary.org/obo/HP_0003371		
HP:0003370	biolink:PhenotypicFeature	Flat capital femoral epiphysis	An abnormal flattening of the proximal epiphysis of the femur.	UMLS:C1842155	hp.json	Flat capital femoral epiphyses|Flat proximal femoral epiphyses|Flat femoral capital epiphyses|Flat end part of innermost thighbone|Flattened proximal femoral epiphyses	http://purl.obolibrary.org/obo/HP_0003370		
HP:0003375	biolink:PhenotypicFeature	Narrow greater sciatic notch	A narrowing of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium.	SNOMEDCT_US:289457006|UMLS:C0566888	hp.json	Narrow sacrosciatic notch|Narrow greater sacrosciatic notches|Narrow sciatic notches|Small sacrosciatic notch|Narrow sacroiliac notch|Small sacrosciatic notches|Narrowed sacrosciatic notch|Narrowed greater sciatic notch	http://purl.obolibrary.org/obo/HP_0003375		
HP:0030969	biolink:PhenotypicFeature	Abnormal pulmonary vein physiology	An abnormality of the function of the pulmonary veins.		hp.json		http://purl.obolibrary.org/obo/HP_0030969		
GO:0043170	biolink:BiologicalProcess	macromolecule metabolic process	The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.		hp.json	multicellular organismal macromolecule metabolic process|organismal macromolecule metabolism|macromolecule metabolism|biopolymer metabolic process	http://purl.obolibrary.org/obo/GO_0043170		goslim_pir
HP:0005929	biolink:PhenotypicFeature	Synostosis involving the tibia		UMLS:C4025103	hp.json	Bone fusion involving the shinbone	http://purl.obolibrary.org/obo/HP_0005929		
HP:0005925	biolink:PhenotypicFeature	Abnormal hand diaphysis morphology		UMLS:C4025106	hp.json	Abnormalities of shaft of long bone of the hand|Abnormalities of the diaphyses of the hand	http://purl.obolibrary.org/obo/HP_0005925		
HP:0005926	biolink:PhenotypicFeature	Abnormal hand cortical bone morphology	An anomaly of the outer shell (cortex) of a hand bone.	UMLS:C4025105	hp.json	Abnormality of hand cortical bone|Abnormality of the cortex of hand bones	http://purl.obolibrary.org/obo/HP_0005926		
HP:0005927	biolink:PhenotypicFeature	Aplasia/hypoplasia involving bones of the hand	Absence (due to failure to form) or underdevelopment of the bones of the hand.	UMLS:C4021612	hp.json	Absent/underdeveloped hand bones|Hypoplasia/absence of hand bones|Absent/small hand bones	http://purl.obolibrary.org/obo/HP_0005927		
GO:0043177	biolink:MolecularActivity	organic acid binding	Binding to an organic acid, any acidic compound containing carbon in covalent linkage.		hp.json		http://purl.obolibrary.org/obo/GO_0043177		
GO:0043176	biolink:MolecularActivity	amine binding	Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group.		hp.json		http://purl.obolibrary.org/obo/GO_0043176		goslim_pir
HP:0005928	biolink:PhenotypicFeature	Synostosis involving the fibula		UMLS:C4025104	hp.json	Bone fusion involving the calf bones	http://purl.obolibrary.org/obo/HP_0005928		
HP:0005921	biolink:PhenotypicFeature	obsolete Abnormal ossification of hand bones			hp.json		http://purl.obolibrary.org/obo/HP_0005921		
HP:0005922	biolink:PhenotypicFeature	Abnormal hand morphology	Any structural anomaly of the hand.	UMLS:C4025109	hp.json	Abnormal shape of hand	http://purl.obolibrary.org/obo/HP_0005922		
UBERON:0005870	biolink:AnatomicalEntity	olfactory pit	An indentation of the olfactory placode which ends when the pits hollows out to form the nasopharynx[GO].	XAO:0004073|EHDAA2:0001295|EMAPA:16800|EFO:0003496|XAO:0000275|EHDAA:4772|AAO:0011068|FMA:295840	hp.json	nasal pit	http://purl.obolibrary.org/obo/UBERON_0005870		pheno_slim|efo_slim
HP:0005923	biolink:PhenotypicFeature	Abnormal hand metaphysis morphology		UMLS:C4025108	hp.json	Abnormality of the wide portion of the hand bone|Abnormalities of the metaphyses of the hand	http://purl.obolibrary.org/obo/HP_0005923		
HP:0005924	biolink:PhenotypicFeature	Abnormal hand epiphysis morphology	Any abnormality of the epiphyses of the phalanges or metacarpal bones.	UMLS:C4025107	hp.json	Abnormality of the epiphyses of the fingers|Abnormality of the end part of the hand bone|Abnormality of the end part of the hand bones|Abnormality of the epiphyses of the hand|Abnormality of the epiphyses of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0005924		
HP:0005920	biolink:PhenotypicFeature	Abnormal epiphysis morphology of the phalanges of the hand	Abnormality of one or all of the epiphyses of the phalanges of the hand. Note that this includes the epiphysis of the 1st metacarpal. In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits).	UMLS:C4021613	hp.json		http://purl.obolibrary.org/obo/HP_0005920		
UBERON:0003216	biolink:AnatomicalEntity	hard palate	Anterior portion of the palate consisting of bone and mucous membranes[GO]. The hard palate is formed from bony processes of the maxilla, premaxilla and palatine[Kardong].	MESH:D021362|UMLS:C0226901|NCIT:C12230|MAT:0000161|FMA:55023|EMAPA:18952|MIAA:0000161|GAID:221|MA:0002477	hp.json	palatum durum|hard palate	http://purl.obolibrary.org/obo/UBERON_0003216		pheno_slim|uberon_slim
UBERON:0005879	biolink:AnatomicalEntity	pharyngeal cleft	An external pocketing of pharyngeal ectoderm that contacts a region of endoderm (a pharyngeal pouch) and interdigitates in the anterior and posterior directions by the pharyngeal arches.	EMAPA:32750|FMA:295672|NCIT:C34250|AAO:0010623|UMLS:C1280559	hp.json	branchial groove|pharyngeal groove|branchial cleft|pharyngeal slit|gill cleft|sulcus pharyngei|Kiemenspalten|pharyngeal ectodermal cleft|pharyngeal groove ectoderm	http://purl.obolibrary.org/obo/UBERON_0005879		pheno_slim
UBERON:0003214	biolink:AnatomicalEntity	mammary gland alveolus	A sac-like structure that is found in the mature gland[GO].	FMA:73285|EMAPA:36566|MA:0002760	hp.json	mammary alveoli|alveolus of mammary gland|lactiferous alveolus|lactiferous gland alveolus|alveolus of lactiferous gland|mammary alveolus|lobe of mammary gland alveolus|alveolus of lobe of breast|lobe of breast alveolus|alveolus of lobe of mammary gland	http://purl.obolibrary.org/obo/UBERON_0003214		pheno_slim
UBERON:0005876	biolink:AnatomicalEntity	undifferentiated genital tubercle	The embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin.	EHDAA2:0000705|FMA:302888|VHOG:0000583|EHDAA:5925|EMAPA:17382	hp.json	phallic tubercle|tuberculum phallicum|undifferentiated genital tubercle|genital tubercle|tuberculum genitale	http://purl.obolibrary.org/obo/UBERON_0005876		pheno_slim
UBERON:0003215	biolink:AnatomicalEntity	alveolus	Organ part that has the form of a hollow cavity[WP].	EV:0100043|FMA:82493|OpenCyc:Mx4rwN8NFZwpEbGdrcN5Y29ycA|NCIT:C12986|UMLS:C0034051|EFO:0002513	hp.json		http://purl.obolibrary.org/obo/UBERON_0003215		efo_slim
UBERON:0005875	biolink:AnatomicalEntity	4th arch pharyngeal cleft	A groove that is situated between the 4th and 5th pharyngeal arch.	VHOG:0000577|EMAPA:16762|EMAPA:16761|EHDAA:1665|RETIRED_EHDAA2:0000088|VHOG:0000968|EHDAA2:0000089	hp.json	4th pharyngeal groove ectoderm|4th branchial cleft|branchial groove of 4th arch|4th pharyngeal groove|4th arch branchial groove|4th arch pharyngeal groove ectoderm|4th pharyngeal cleft	http://purl.obolibrary.org/obo/UBERON_0005875		vertebrate_core
UBERON:0003212	biolink:AnatomicalEntity	gustatory organ	Any sense organ that functions in (some) detection of chemical stimulus involved in sensory perception of taste (GO:0050912).	FMA:77853|FBbt:00005159	hp.json	taste organ|organ of gustatory system|organ of gustatory organ system|organ of taste system|gustatory system organ|gustatory organ system organ|taste system organ	http://purl.obolibrary.org/obo/UBERON_0003212		
UBERON:0005874	biolink:AnatomicalEntity	3rd arch pharyngeal cleft	A groove that is situated between the 3rd and 4th pharyngeal arch.	VHOG:0000973|EHDAA2:0000074|EHDAA:1082|VHOG:0000572|EMAPA:16581	hp.json	3rd pharyngeal groove|3rd branchial cleft|3rd pharyngeal cleft|3rd pharyngeal groove ectoderm|branchial groove of 3rd arch|3rd arch groove ectoderm|3rd arch branchial groove	http://purl.obolibrary.org/obo/UBERON_0005874		vertebrate_core
UBERON:0005873	biolink:AnatomicalEntity	2nd arch pharyngeal cleft	A groove that is situated between the 2nd and 3rd pharyngeal arch.	VHOG:0000972|EHDAA:613|EMAPA:16396|EHDAA2:0000057|VHOG:0000568	hp.json	2nd branchial cleft|branchial groove of 2nd arch|2nd arch branchial groove|2nd pharyngeal groove ectoderm|2nd pharyngeal cleft|2nd arch groove ectoderm|2nd pharyngeal groove	http://purl.obolibrary.org/obo/UBERON_0005873		vertebrate_core
UBERON:0005872	biolink:AnatomicalEntity	1st arch pharyngeal cleft	A groove that is situated between the 1st and 2nd pharyngeal arch.	VHOG:0000554|EMAPA:16119|EHDAA2:0000009|VHOG:0000969|EHDAA:575	hp.json	branchial groove of 1st arch|1st arch groove ectoderm|1st pharyngeal cleft|1st pharyngeal groove ectoderm|1st pharyngeal groove|1st branchial cleft|1st arch branchial groove	http://purl.obolibrary.org/obo/UBERON_0005872		vertebrate_core
GO:0043184	biolink:MolecularActivity	vascular endothelial growth factor receptor 2 binding	Binding to a vascular endothelial growth factor receptor 2.		hp.json	VEGF receptor 2 binding|KDR binding|Flk-1 binding|VEGFR 2 binding|kinase domain region binding	http://purl.obolibrary.org/obo/GO_0043184		
HP:0005938	biolink:PhenotypicFeature	Abnormal respiratory motile cilium morphology	Abnormal arrangement of the structures of the motile cilium.	UMLS:C4025100	hp.json		http://purl.obolibrary.org/obo/HP_0005938		
HP:0005939	biolink:PhenotypicFeature	Multiple bilateral pneumothoraces		UMLS:C4025099	hp.json		http://purl.obolibrary.org/obo/HP_0005939		
HP:0005932	biolink:PhenotypicFeature	Abnormal renal corticomedullary differentiation	An abnormality of corticomedullary differentiation (CMD) on diagnostic imaging such as magnetic resonance imaging, computer tomography, or sonography. CMD is a difference in the visualization of cortex and medulla.	UMLS:C4025102	hp.json		http://purl.obolibrary.org/obo/HP_0005932		
HP:0030900	biolink:PhenotypicFeature	Pruritus on foot	Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the foot.		hp.json	Itchy foot|Itchy feet	http://purl.obolibrary.org/obo/HP_0030900		
HP:0005934	biolink:PhenotypicFeature	Imperfect vocal cord adduction		UMLS:C4025101	hp.json		http://purl.obolibrary.org/obo/HP_0005934		
HP:0030901	biolink:PhenotypicFeature	Pruritis on breast	Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the skin of the breast.		hp.json		http://purl.obolibrary.org/obo/HP_0030901		
HP:0030902	biolink:PhenotypicFeature	Palmomental reflex	A type of primitive reflex characterized by an involuntary contraction of the mentalis muscle of the chin caused by stimulation of the thenar eminence of the palm.		hp.json		http://purl.obolibrary.org/obo/HP_0030902		
HP:0005930	biolink:PhenotypicFeature	Abnormal epiphysis morphology	An anomaly of epiphysis, which is the expanded articular end of a long bone that developes from a secondary ossification center, and which during the period of growth is either entirely cartilaginous or is separated from the shaft by a cartilaginous disk.	UMLS:C4021611	hp.json	Epiphyseal abnormality|Anomaly of the epiphyses|Abnormality of epiphysis morphology|Abnormal shape of end part of bone|Abnormality of the epiphyses	http://purl.obolibrary.org/obo/HP_0005930		
UBERON:0005868	biolink:AnatomicalEntity	maxillary prominence	The paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw.	FMA:293049|UMLS:C1513037|EMAPA:17359|EHDAA2:0001070|NCIT:C34206|EHDAA:5877	hp.json	maxillary process of embryo|maxillary process|prominentia maxilaris|embryonic maxillary process	http://purl.obolibrary.org/obo/UBERON_0005868		pheno_slim
HP:0030907	biolink:PhenotypicFeature	Thunderclap headache	Severe head pain with sudden onset, reaching its maximum intensity in less than one minute and lasting from one hour to ten days.		hp.json		http://purl.obolibrary.org/obo/HP_0030907		
UBERON:0005867	biolink:AnatomicalEntity	mandibular prominence	The paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip.	UMLS:C1512982|EHDAA:5871|Wikipedia:Mandibular_prominence|EHDAA2:0001061|FMA:293051|EMAPA:17355|NCIT:C34204	hp.json	mandibular swelling|prominentia mandibularis|mandibular process|mandibular swelling|prominentia mandibularis|mandibular process	http://purl.obolibrary.org/obo/UBERON_0005867		pheno_slim
HP:0030908	biolink:PhenotypicFeature	Liver kidney microsome type 1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against P450 2D6, a cytochrome P450 mono-oxygenase. Anti-LKM-1 antibodies are considered to be a diagnostic marker of autoimmune hepatitis type 2 (AIH2).		hp.json	Anti-LKM-1 positive|Anti-LKM1 antibody positivity|Anti-liver kidney microsomal type 1 antibody positivity|Anti-type I liver-kidney microsomal antibody positivity	http://purl.obolibrary.org/obo/HP_0030908		
UBERON:0005866	biolink:AnatomicalEntity	pre-cartilage condensation	A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts.	EHDAA2:0003150|AEO:0000150|EMAPA:32736	hp.json	pre-chondrogenic condensation|precartilagenous condensation|precartilage condensation|prechondrogenic condensation	http://purl.obolibrary.org/obo/UBERON_0005866		
HP:0030909	biolink:PhenotypicFeature	Anti-liver cytosolic antigen type 1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against a 60-kd peptide contained in the liver cytosolic fraction.		hp.json	Anti-liver cytosol antibody-1 positivity	http://purl.obolibrary.org/obo/HP_0030909		
UBERON:0005865	biolink:AnatomicalEntity	pre-muscle condensation		AEO:0000149|EHDAA2_RETIRED:0003149	hp.json	pre muscle mass|premuscle mass	http://purl.obolibrary.org/obo/UBERON_0005865		
HP:0030903	biolink:PhenotypicFeature	Grasp reflex	A type of primitive reflex that can be elicated when the hand of the examiner is gently inserted into the palm of the patient's hand. The palmar surface is stroked or simply touched. The flexor surfaces of the fingers may be stimulated also by the examiner's fingers. The stimulus should be in a distal direction. With a positive response, the patient grasps the examiner's hand with variable strength and continues to grasp as the examiner's hand is moved. Ability to release the grip voluntarily depends on the activity of the reflex; some patients can do so readily, while others can even be lifted off the bed, since the grasp has such power [NCBI Books:NBK395].		hp.json	Palmar grasp reflex	http://purl.obolibrary.org/obo/HP_0030903		
UBERON:0005863	biolink:AnatomicalEntity	cartilaginous condensation	Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes.	EMAPA:32731|AEO:0000147|EHDAA2_RETIRED:0003147|VSAO:0000092|XAO:0004022	hp.json	chondrogenic condensation|cartilage condensation|cartilagenous condensation	http://purl.obolibrary.org/obo/UBERON_0005863		
HP:0030904	biolink:PhenotypicFeature	Glabellar reflex	A type of primitive reflex that is elicited by repetitive tapping on the forehead. Normal subjects usually blink in response to the first several taps, but if blinking persists, the response is abnormal and considered to be a sign of frontal release. Persistent blinking is also known as Myerson's sign.		hp.json	Myerson's sign	http://purl.obolibrary.org/obo/HP_0030904		
HP:0030905	biolink:PhenotypicFeature	Snout reflex	A type of primitive reflex that is elicited by tapping the upper lip lightly. The contraction of the muscles causes the mouth to resemble a snout.		hp.json		http://purl.obolibrary.org/obo/HP_0030905		
HP:0030906	biolink:PhenotypicFeature	Suck reflex	A type of primitive reflex that is elicited by lightly touching or tapping on the lips with an object such as a tongue blade, reflex hammer, or the examiner's finger. At times the reflex is obtained merely by approaching the lips with an object. A positive suck reflex consists of sucking movements by the lips when they are stroked or touched.		hp.json	Persistent nutritive suckle swallow	http://purl.obolibrary.org/obo/HP_0030906		
GO:0080135	biolink:BiologicalProcess	regulation of cellular response to stress	Any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).		hp.json		http://purl.obolibrary.org/obo/GO_0080135		
GO:0043199	biolink:MolecularActivity	sulfate binding	Binding to sulfate, SO4(2-), a negatively charged small molecule.		hp.json		http://purl.obolibrary.org/obo/GO_0043199		
HP:0005905	biolink:PhenotypicFeature	Abnormal cervical curvature	The presence of an abnormal curvature of the cervical vertebral column.	UMLS:C3151523	hp.json	Abnormal neck curve	http://purl.obolibrary.org/obo/HP_0005905		
OBO:uberon/core#trunk_part_of	biolink:NamedThing	trunk_part_of			hp.json		http://purl.obolibrary.org/obo/uberon/core#trunk_part_of		
GO:0080134	biolink:BiologicalProcess	regulation of response to stress	Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).		hp.json		http://purl.obolibrary.org/obo/GO_0080134		gocheck_do_not_manually_annotate
HP:0005906	biolink:PhenotypicFeature	Delayed pneumatization of the mastoid process	An abnormally reduced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms.	UMLS:C4021617	hp.json	Mastoid processes poorly pneumatized	http://purl.obolibrary.org/obo/HP_0005906		hposlim_core
HP:0030911	biolink:PhenotypicFeature	Bifid clitoris	Two clitorides located side by side.		hp.json		http://purl.obolibrary.org/obo/HP_0030911		
HP:0005900	biolink:PhenotypicFeature	Fifth metacarpal with ulnar notch	Presence of an angular or V -shaped indentation on the ulnar side of the fifth metacarpal bone (i.e., on the sides towards the fifth finger).	UMLS:C3276324	hp.json	Fifth metacarpal notched on ulnar side	http://purl.obolibrary.org/obo/HP_0005900		
HP:0030912	biolink:PhenotypicFeature	Duplicated clitoris	Supernumerary clitoris.		hp.json		http://purl.obolibrary.org/obo/HP_0030912		
HP:0005901	biolink:PhenotypicFeature	obsolete Chronic recurrent multifocal osteomyelitis			hp.json		http://purl.obolibrary.org/obo/HP_0005901		
HP:0030913	biolink:PhenotypicFeature	Exaggerated rugosity of the labia majora	Marked rugae formation of the skin of the labia majora.		hp.json	Scrotum-like labia majora	http://purl.obolibrary.org/obo/HP_0030913		
HP:0030918	biolink:PhenotypicFeature	Low 1-minute APGAR score			hp.json	Low one-minute APGAR score	http://purl.obolibrary.org/obo/HP_0030918		
UBERON:0005856	biolink:AnatomicalEntity	developing mesenchymal condensation	A delimited region of dense mesenchyme within looser mesenchyme.	AEO:0000148|EHDAA2_RETIRED:0003148|EHDAA:8979	hp.json	mesenchyme condensation	http://purl.obolibrary.org/obo/UBERON_0005856		
HP:0030919	biolink:PhenotypicFeature	Low 5-minute APGAR score			hp.json	Low five-minute APGAR score	http://purl.obolibrary.org/obo/HP_0030919		
UBERON:0005855	biolink:AnatomicalEntity	lumbar spinal cord ventral column	A subdivision of spinal cord ventral column that is part of a lumbar spinal cord.	BIRNLEX:840	hp.json		http://purl.obolibrary.org/obo/UBERON_0005855		
UBERON:0005854	biolink:AnatomicalEntity	cervical spinal cord ventral column	A subdivision of spinal cord ventral column that is part of a cervical spinal cord.	UMLS:C1278746|UMLS:C0228619|BIRNLEX:1660	hp.json	cervical spinal cord anterior column	http://purl.obolibrary.org/obo/UBERON_0005854		
UBERON:0005853	biolink:AnatomicalEntity	sacral spinal cord ventral column	A subdivision of spinal cord ventral column that is part of a sacral spinal cord.	BIRNLEX:1520	hp.json		http://purl.obolibrary.org/obo/UBERON_0005853		
HP:0030914	biolink:PhenotypicFeature	Abnormal peristalsis	An anomaly of the wave-like muscle contractions of the digestive tract.		hp.json		http://purl.obolibrary.org/obo/HP_0030914		
UBERON:0005852	biolink:AnatomicalEntity	thoracic spinal cord ventral column	A subdivision of spinal cord ventral column that is part of a thoracic spinal cord.	UMLS:C1288556|BIRNLEX:1448|UMLS:C0228636	hp.json		http://purl.obolibrary.org/obo/UBERON_0005852		
HP:0030915	biolink:PhenotypicFeature	Cerebellar edema	Swelling from fluid accumulation (serous fluid infiltration into the interstitial space) in the cerebellum.		hp.json	Oedema of the cerebellum|Cerebellar oedema|Edema of the cerebellum	http://purl.obolibrary.org/obo/HP_0030915		
HP:0030917	biolink:PhenotypicFeature	Low APGAR score			hp.json		http://purl.obolibrary.org/obo/HP_0030917		
CHEBI:46883	biolink:ChemicalSubstance	carboxy group		PDBeChem:FMT	hp.json	carboxy|-COOH|-CO2H|carboxyl group|CARBOXY GROUP|-C(O)OH	http://purl.obolibrary.org/obo/CHEBI_46883		3_STAR
UBERON:0005838	biolink:AnatomicalEntity	fasciculus of brain	A fascicle that is part of a brain.	FMA:83844	hp.json	brain fasciculus	http://purl.obolibrary.org/obo/UBERON_0005838		
UBERON:0005837	biolink:AnatomicalEntity	fasciculus of spinal cord	A fascicle that is part of a spinal cord.	FMA:75799	hp.json	spinal cord fasciculus	http://purl.obolibrary.org/obo/UBERON_0005837		
HP:0005918	biolink:PhenotypicFeature	Abnormal finger phalanx morphology	Abnormalities affecting the phalanx of finger.	UMLS:C4021614	hp.json	Abnormality of the phalanges|Abnormal form of phalanges of the hand|Abnormality of the finger bones|Abnormality of the phalanges of the hand|Abnormality of phalanx of finger	http://purl.obolibrary.org/obo/HP_0005918		
HP:0005914	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the metacarpal bones	Aplasia or Hypoplasia affecting the metacarpal bones.	UMLS:C1836192	hp.json	Hypoplastic/absent metacarpal bones|Absent/underdeveloped long bones of hand|Metacarpal aplasia/hypoplasia|Absent or hypoplastic metacarpals|Hypoplastic/absent metacarpals|Absent/small long bones of hand|Hypoplastic metacarpals|Aplastic/hypoplastic metacarpals	http://purl.obolibrary.org/obo/HP_0005914		
HP:0005916	biolink:PhenotypicFeature	Abnormal metacarpal morphology	Irregularly shaped metacarpal bones of varying degree.	UMLS:C4021615	hp.json	Abnormal shape of long bones of hand|Abnormal shape of metacarpal bones	http://purl.obolibrary.org/obo/HP_0005916		
HP:0005917	biolink:PhenotypicFeature	Supernumerary metacarpal bones	The presence of more than the normal number of metacarpal bones.	UMLS:C0545617|SNOMEDCT_US:91846008	hp.json	Extra long bones of hand	http://purl.obolibrary.org/obo/HP_0005917		
HP:0030921	biolink:PhenotypicFeature	5-minute APGAR score of 1			hp.json		http://purl.obolibrary.org/obo/HP_0030921		
HP:0005910	biolink:PhenotypicFeature	Rhomboid or triangular shaped 5th finger middle phalanx	Rhomboid or triangular shaped 5th (little) finger middle phalanx.	UMLS:C4021616	hp.json	Rhomboid or triangular shaped fifth finger middle phalanx	http://purl.obolibrary.org/obo/HP_0005910		
HP:0030922	biolink:PhenotypicFeature	5-minute APGAR score of 2			hp.json		http://purl.obolibrary.org/obo/HP_0030922		
HP:0030923	biolink:PhenotypicFeature	5-minute APGAR score of 3			hp.json		http://purl.obolibrary.org/obo/HP_0030923		
HP:0005912	biolink:PhenotypicFeature	Biliary atresia	Atresia of the biliary tree.	MSH:D001656|SNOMEDCT_US:82821008|SNOMEDCT_US:77480004|UMLS:C0005411	hp.json	Biliary duct atresia	http://purl.obolibrary.org/obo/HP_0005912		
HP:0030924	biolink:PhenotypicFeature	5-minute APGAR score of 4			hp.json		http://purl.obolibrary.org/obo/HP_0030924		
HP:0005913	biolink:PhenotypicFeature	Abnormal metacarpal epiphysis morphology		UMLS:C4025110	hp.json	Abnormality of end part of long bone of hand|Abnormality of metacarpal epiphyses	http://purl.obolibrary.org/obo/HP_0005913		
HP:0030920	biolink:PhenotypicFeature	5-minute APGAR score of 0			hp.json		http://purl.obolibrary.org/obo/HP_0030920		
HP:0030929	biolink:PhenotypicFeature	1-minute APGAR score of 2			hp.json		http://purl.obolibrary.org/obo/HP_0030929		
UBERON:0005845	biolink:AnatomicalEntity	caudal segment of spinal cord	A spinal cord segment that adjacent_to a caudal region.	FMA:256635|MA:0003084	hp.json	coccygeal segments of spinal cord [1-3]|coccygeal segment of spinal cord|segmenta coccygea medullae spinalis [1-3]|segmenta coccygea|pars coccygea medullae spinalis	http://purl.obolibrary.org/obo/UBERON_0005845		
UBERON:0005844	biolink:AnatomicalEntity	spinal cord segment		FMA:62420|BIRNLEX:2665|MA:0003080|SCTID:278748001	hp.json	axial regional part of spinal cord|spinal neuromeres|axial part of spinal cord|segment of spinal cord	http://purl.obolibrary.org/obo/UBERON_0005844		
UBERON:0005843	biolink:AnatomicalEntity	sacral spinal cord	A spinal cord segment that adjacent_to a sacral region.	NCIT:C12896|UMLS:C0581669|UMLS:C0581669|MA:0003085|FMA:256623|UMLS:C1280196|BIRNLEX:1275	hp.json	sacral segment of spinal cord|segmenta sacralia medullae spinalis [1-5]|pars sacralis medullae spinalis|sacral segments of spinal cord [1-5]	http://purl.obolibrary.org/obo/UBERON_0005843		
HP:0030925	biolink:PhenotypicFeature	5-minute APGAR score of 5			hp.json		http://purl.obolibrary.org/obo/HP_0030925		
HP:0030926	biolink:PhenotypicFeature	5-minute APGAR score of 6			hp.json		http://purl.obolibrary.org/obo/HP_0030926		
HP:0030927	biolink:PhenotypicFeature	1-minute APGAR score of 0			hp.json		http://purl.obolibrary.org/obo/HP_0030927		
HP:0030928	biolink:PhenotypicFeature	1-minute APGAR score of 1			hp.json		http://purl.obolibrary.org/obo/HP_0030928		
UBERON:0015238	biolink:AnatomicalEntity	pineal complex	A cluster in the epithalamus that consists of the pineal body and any associated structures, such as the parapineal gland or the parietal organ. The complex is poorly developed in mammals.	ZFA:0001359|TAO:0001359	hp.json		http://purl.obolibrary.org/obo/UBERON_0015238		
HP:0003309	biolink:PhenotypicFeature	Ovoid thoracolumbar vertebrae		UMLS:C1868556	hp.json	Ovoid thoracic and lumbar vertebrae	http://purl.obolibrary.org/obo/HP_0003309		
HP:0003308	biolink:PhenotypicFeature	Cervical subluxation	A partial dislocation of one or more intervertebral joints in the cervical vertebral column.	UMLS:C1846798	hp.json		http://purl.obolibrary.org/obo/HP_0003308		
HP:0003307	biolink:PhenotypicFeature	Hyperlordosis	Abnormally increased curvature (anterior concavity) of the lumbar or cervical spine.	UMLS:C0024003|SNOMEDCT_US:249710008|MSH:D008141|SNOMEDCT_US:61960001	hp.json	Prominent swayback|Lordosis	http://purl.obolibrary.org/obo/HP_0003307		hposlim_core
UBERON:0015233	biolink:AnatomicalEntity	nucleus of dorsal thalamus	A nucleus of brain that is part of a dorsal thalamus.		hp.json	dorsal thalamic nucleus|nucleus of thalamus proper	http://purl.obolibrary.org/obo/UBERON_0015233		
GO:0080154	biolink:BiologicalProcess	regulation of fertilization	Any process that modulates the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).		hp.json		http://purl.obolibrary.org/obo/GO_0080154		
HP:0003302	biolink:PhenotypicFeature	Spondylolisthesis	Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the vertebra.	UMLS:C0038016|SNOMEDCT_US:274152003|MSH:D013168	hp.json	Spondylolithesis|Slipped backbone|Displacement of one backbone compared to another	http://purl.obolibrary.org/obo/HP_0003302		
UBERON:0003252	biolink:AnatomicalEntity	thoracic rib cage	Subdivision of skeletal system that consists of all ribs in an organism connected to the sternum and the vertebrae. Some vertebrates have abdominal ribs (gastrialia), not connected to the vertebrate - these are not considered part of the rib case.	galen:RibCage|FMA:7480	hp.json	rib cage|cavea thoracis|thoracic cage|cavea thoracis	http://purl.obolibrary.org/obo/UBERON_0003252		pheno_slim
UBERON:0003253	biolink:AnatomicalEntity	neck of rib	The neck of the rib is the flattened portion which extends lateralward from the head; it is about 2.5 cm. long, and is placed in front of the transverse process of the lower of the two vertebrC& with which the head articulates. Its anterior surface is flat and smooth, its posterior rough for the attachment of the ligament of the neck, and perforated by numerous foramina. Of its two borders the superior presents a rough crest (crista colli costE) for the attachment of the anterior costotransverse ligament; its inferior border is rounded. On the posterior surface at the junction of the neck and body, and nearer the lower than the upper border, is an eminencebthe tubercle; it consists of an articular and a non-articular portion. The articular portion, the lower and more medial of the two, presents a small, oval surface for articulation with the end of the transverse process of the lower of the two vertebrC& to which the head is connected. The non-articular portion is a rough elevation, and affords attachment to the ligament of the tubercle. The tubercle is much more prominent in the upper than in the lower ribs.	EMAPA:37826|FMA:7576	hp.json	rib neck|collum costae|collum costae	http://purl.obolibrary.org/obo/UBERON_0003253		
HP:0003301	biolink:PhenotypicFeature	Irregular vertebral endplates	An irregular surface of the vertebral end plates, which are normally relatively smooth.	UMLS:C1842153	hp.json	irregular vertebral plates|Irregular endplates|end-plate irregularities|endplate irregularity|vertebral endplate irregularity|Irregular end plates|endplate irregularities	http://purl.obolibrary.org/obo/HP_0003301		hposlim_core
HP:0003300	biolink:PhenotypicFeature	Ovoid vertebral bodies	When viewed in lateral radiographs, vertebral bodies have a roughly rectangular configuration. This term applies if the vertebral body appears rounded or oval.	UMLS:C1855665|UMLS:C4020844	hp.json	Ovoid vertebrae|Ovoid-shaped vertebral bodies|Oval vertebral bodies|Bullet vertebral body	http://purl.obolibrary.org/obo/HP_0003300		
HP:0005967	biolink:PhenotypicFeature	Mixed respiratory and metabolic acidosis		UMLS:C1840372	hp.json		http://purl.obolibrary.org/obo/HP_0005967		
HP:0005968	biolink:PhenotypicFeature	Temperature instability	Disordered thermoregulation characterized by an impaired ability to maintain a balance between heat production and heat loss, with resulting instability of body temperature.	UMLS:C3279038|UMLS:C1820737	hp.json	Body temperature instability|Temperature instability	http://purl.obolibrary.org/obo/HP_0005968		
HP:0003306	biolink:PhenotypicFeature	Spinal rigidity	Reduced ability to move the vertebral column with a resulting limitation of neck and trunk flexion.	UMLS:C1858025	hp.json	Rigid spine|Reduced spine movement	http://purl.obolibrary.org/obo/HP_0003306		
HP:0005961	biolink:PhenotypicFeature	Hypoargininemia	A decreased concentration of arginine in the blood.	UMLS:C1859735|UMLS:C4025095	hp.json	Low blood arginine levels|Arginine deficiency	http://purl.obolibrary.org/obo/HP_0005961		
HP:0003305	biolink:PhenotypicFeature	Block vertebrae	Congenital synostosis between two or more adjacent vertebrae (partial or complete fusion of adjacent vertabral bodies).	UMLS:C1844753	hp.json		http://purl.obolibrary.org/obo/HP_0003305		
HP:0003304	biolink:PhenotypicFeature	Spondylolysis	Spondylolysis is an osseous defect of the pars interarticularis, thought to be a developmental or acquired stress fracture secondary to chronic low-grade trauma.	UMLS:C0038018|SNOMEDCT_US:240221008|MSH:D013169	hp.json		http://purl.obolibrary.org/obo/HP_0003304		hposlim_core
HP:0005964	biolink:PhenotypicFeature	Intermittent hypothermia	Episodes of reduced body termperature.	UMLS:C1837639	hp.json	Intermittent abnormally low body temperature|Intermittent hypothermia	http://purl.obolibrary.org/obo/HP_0005964		
UBERON:0003258	biolink:AnatomicalEntity	endoderm of foregut	An endoderm that is part of a foregut [Automatically generated definition].	EHDAA:524|EHDAA2:0004568	hp.json	foregut endoderm	http://purl.obolibrary.org/obo/UBERON_0003258		
UBERON:0003259	biolink:AnatomicalEntity	endoderm of midgut	An endoderm that is part of a midgut [Automatically generated definition].	EHDAA:987|EMAPA:16257|RETIRED_EHDAA2:0001194|VHOG:0001080	hp.json	midgut endoderm	http://purl.obolibrary.org/obo/UBERON_0003259		
UBERON:0003257	biolink:AnatomicalEntity	yolk sac endoderm	The portion of the yolk sac that is derived from endoderm and lines the yolk sac.	EHDAA2:0002215|VHOG:0000626|EMAPA:16086|EHDAA:166	hp.json		http://purl.obolibrary.org/obo/UBERON_0003257		
UBERON:0003254	biolink:AnatomicalEntity	amniotic ectoderm		EHDAA2:0000117|EHDAA:138|EMAPA:16110|BTO:0000897|VHOG:0000621	hp.json	amnion ectoderm|amnionic ectoderm|amnionic ectoderm|amnion epithelium|amnion ectoderm	http://purl.obolibrary.org/obo/UBERON_0003254		
HP:0003319	biolink:PhenotypicFeature	Abnormality of the cervical spine	Any abnormality of the cervical vertebral column.	UMLS:C1852464	hp.json	Cervical vertebral abnormalities|Abnormality of the cervical vertebrae|Abnormal cervical spine|Disorder of cervical vertebra|Cervical vertebral anomalies|Cervical spine abnormalities|Abnormality of cervical vertebra	http://purl.obolibrary.org/obo/HP_0003319		
UBERON:0015228	biolink:AnatomicalEntity	circulatory organ	A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile.	SPD:0000130	hp.json	circulatory vessel|heart or heart like organ|cardiac pump|heart|cardiac structure	http://purl.obolibrary.org/obo/UBERON_0015228		grouping_class
HP:0003318	biolink:PhenotypicFeature	Cervical spine hypermobility		SNOMEDCT_US:298186005|UMLS:C0574967	hp.json	Cervical spine joint hypermobility	http://purl.obolibrary.org/obo/HP_0003318		
GO:0080144	biolink:BiologicalProcess	amino acid homeostasis	Any process involved in the maintenance of an internal steady state of amino acid within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0080144		
HP:0005976	biolink:PhenotypicFeature	Hyperkalemic metabolic acidosis		UMLS:C1865880	hp.json		http://purl.obolibrary.org/obo/HP_0005976		
HP:0005977	biolink:PhenotypicFeature	Hypochloremic metabolic alkalosis		UMLS:C0740895	hp.json		http://purl.obolibrary.org/obo/HP_0005977		
HP:0003312	biolink:PhenotypicFeature	Abnormal form of the vertebral bodies	Abnormal morphology of vertebral body.	UMLS:C1839326	hp.json	Abnormally shaped vertebrae	http://purl.obolibrary.org/obo/HP_0003312		
HP:0003311	biolink:PhenotypicFeature	Hypoplasia of the odontoid process	Developmental hypoplasia of the dens of the axis.	UMLS:C1846439	hp.json	Hypoplastic odontoid process|Small odontoid process|Small odontoid peg|Odontoid hypoplasia	http://purl.obolibrary.org/obo/HP_0003311		hposlim_core
HP:0005978	biolink:PhenotypicFeature	Type II diabetes mellitus	A type of diabetes mellitus initially characterized by insulin resistance and hyperinsulinemia and subsequently by glucose interolerance and hyperglycemia.	UMLS:C0011860|MSH:D003924|SNOMEDCT_US:44054006	hp.json	Noninsulin dependent diabetes mellitus|Non-insulin dependent diabetes|Noninsulin-dependent diabetes|Diabetes mellitus type 2|Noninsulin-dependent diabetes mellitus|NIDDM|Diabetes mellitus Type II|Type II diabetes|Diabetes mellitus, noninsulin-dependent|NIDDM diabetes mellitus|Type 2 diabetes	http://purl.obolibrary.org/obo/HP_0005978		
HP:0005979	biolink:PhenotypicFeature	Metabolic ketoacidosis	A metabolic acidosis due to accumulation of ketone bodies generally observed in the setting of poor nutritional intake.	MSH:D007662|UMLS:C1854704	hp.json	Starvation ketoacidosis	http://purl.obolibrary.org/obo/HP_0005979		
HP:0003310	biolink:PhenotypicFeature	Abnormality of the odontoid process	Abnormality of the dens of the axis, which is also known as the odontoid process.	UMLS:C1864794	hp.json	Abnormal odontoid peg|Abnormal odontoid process	http://purl.obolibrary.org/obo/HP_0003310		
HP:0005972	biolink:PhenotypicFeature	Respiratory acidosis	Acidosis because of respiratory retention of carbon dioxide.	SNOMEDCT_US:12326000|UMLS:C0001127|MSH:D000142	hp.json		http://purl.obolibrary.org/obo/HP_0005972		
HP:0005973	biolink:PhenotypicFeature	Fructose intolerance	Reduced intestinal absorption of fructose. Breath testing after ingestion of fructose has been widely adopted as a standard method of identifying fructose malabsorption and intolerance. A dose of 25 g of fructose dissolved in a 10% solution is generally accepted as the appropriate dose of fructose for clinical use of H2 and CH4 breath testing. High levels of hydrogen in exhaled breath subsequent hours indicate fructose intolerance. Presence of malabsorption and reproduction of symptoms during a breath test provides the best objective evidence and symptom correlation for fructose intolerance.	UMLS:C0016751|SNOMEDCT_US:20052008|MSH:D005633	hp.json	Fructose malabsorption	http://purl.obolibrary.org/obo/HP_0005973		
HP:0003316	biolink:PhenotypicFeature	Butterfly vertebrae	A butterfly vertebra (sagittal cleft vertebra or anterior rachischisis) is a sagittal defect in the vertebral body caused by failure of fusion of the two lateral chondrification centers during embryogenesis. The name is based on the appearance of the two hemivertebrae emerging as butterfly wings from the central cleft on x-ray.	UMLS:C1844752	hp.json	Sagittal clefting of vertebrae|Butterfly vertebrae|Anterior rachischisis	http://purl.obolibrary.org/obo/HP_0003316		
HP:0005974	biolink:PhenotypicFeature	Episodic ketoacidosis	Intermittent episodes of ketoacidosis.	UMLS:C1859860	hp.json	Ketoacidosis, episodic	http://purl.obolibrary.org/obo/HP_0005974		
UBERON:0003249	biolink:AnatomicalEntity	epithelium of otic placode	An epithelium that is part of a otic placode [Automatically generated definition].	EHDAA:510|EMAPA:16197|VHOG:0000636|ZFA:0007068|EHDAA2:0001341	hp.json	epithelial tissue of otic placode|otic epithelium|otic placode epithelial tissue|otic placode epithelium	http://purl.obolibrary.org/obo/UBERON_0003249		
UBERON:0003247	biolink:AnatomicalEntity	epithelium of forearm	An epithelium that is part of a lower arm [Automatically generated definition].	EHDAA:4174|EHDAA:6220|VHOG:0001096|EHDAA2:0000554|EMAPA:17418	hp.json	forearm epithelium	http://purl.obolibrary.org/obo/UBERON_0003247		
UBERON:0003248	biolink:AnatomicalEntity	epithelium of footplate	An epithelium that is part of a footplate.	EHDAA2:0000548|EMAPA:32655|EHDAA:5145|EHDAA:6144	hp.json	foot plate epithelium|footplate epithelium	http://purl.obolibrary.org/obo/UBERON_0003248		
UBERON:0003243	biolink:AnatomicalEntity	epithelium of cochlear duct	An epithelium that is part of a cochlear duct of membranous labyrinth [Automatically generated definition].	EMAPA:17600|RETIRED_EHDAA2:0000264|EHDAA:4722|VHOG:0000640	hp.json	cochlear duct epithelial tissue|cochlear duct epithelium|epithelial tissue of Reissner's canal|cochlear duct of membranous labyrinth epithelium|epithelium of Reissner's canal|Reissner's canal epithelium|epithelium of cochlear duct of membranous labyrinth|epithelial tissue of cochlear duct of membranous labyrinth|Reissner's canal epithelial tissue|epithelial tissue of cochlear duct|cochlear duct of membranous labyrinth epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003243		
UBERON:0003244	biolink:AnatomicalEntity	epithelium of mammary gland	The epithelial layer of the luminal surfaces of the mammary gland.	UMLS:C0596882|VHOG:0001088|CALOHA:TS-0593|EHDAA:6526|EMAPA:17760|MA:0000792|FMA:74445|EHDAA2:0001057|NCIT:C12937|BTO:0001430	hp.json	mammary gland epithelium|lactiferous gland epithelium|mammary epithelium|mammary gland epithelial tissue|epithelium of lactiferous gland	http://purl.obolibrary.org/obo/UBERON_0003244		pheno_slim
CHEBI:22881	biolink:ChemicalSubstance	biopterins		MetaCyc:All-Biopterines	hp.json		http://purl.obolibrary.org/obo/CHEBI_22881		3_STAR
UBERON:7500033	biolink:AnatomicalEntity	distal-most point of medial condyle of femur	The distal-most point of the medial condyle of a femur.		hp.json		http://purl.obolibrary.org/obo/UBERON_7500033		
UBERON:0003229	biolink:AnatomicalEntity	epithelium of elbow	An epithelium that is part of a elbow [Automatically generated definition].	EHDAA2:0000430|EHDAA:4168|EHDAA:6214|EMAPA:17415|VHOG:0001044	hp.json	cubital region epithelial tissue|elbow epithelium|epithelial tissue of cubital region|epithelial tissue of elbow|epithelium of cubital region|elbow epithelial tissue|cubital region epithelium	http://purl.obolibrary.org/obo/UBERON_0003229		
UBERON:0015212	biolink:AnatomicalEntity	lateral structure	Any structure that is placed on one side of the left-right axis of a bilaterian.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015212		non_informative|grouping_class
HP:0005947	biolink:PhenotypicFeature	Decreased sensitivity to hypoxemia	Reduced tendency to respond to a reduced concentration of oxygen in the blood by increasing respiration.	UMLS:C3806286	hp.json	Decreased sensitivity to hypoxaemia|Decreased sensitivity to hypoxemia	http://purl.obolibrary.org/obo/HP_0005947		
HP:0005948	biolink:PhenotypicFeature	Multiple pulmonary cysts	The presence of multiple lung cysts.	MSH:C563237|UMLS:C1384901	hp.json	Multiple lung cysts|Cystic lung disease	http://purl.obolibrary.org/obo/HP_0005948		
HP:0005949	biolink:PhenotypicFeature	Apneic episodes in infancy	Recurrent episodes of apnea occurring during infancy.	UMLS:C3807980	hp.json		http://purl.obolibrary.org/obo/HP_0005949		
UBERON:0015214	biolink:AnatomicalEntity	arcuate ligament	A ligament that is part of a diaphragm.	EMAPA:19236|FMA:58280	hp.json		http://purl.obolibrary.org/obo/UBERON_0015214		
HP:0005943	biolink:PhenotypicFeature	Respiratory arrest		UMLS:C0162297|SNOMEDCT_US:87317003	hp.json	Breathing cessation	http://purl.obolibrary.org/obo/HP_0005943		
UBERON:0003230	biolink:AnatomicalEntity	epithelium of carpal region	An epithelium that is part of a wrist [Automatically generated definition].	EHDAA2:0000219|EHDAA:5198	hp.json	epithelium of wrist|epithelial tissue of wrist|carpal region epithelium|epithelial tissue of carpal region|wrist epithelial tissue|wrist epithelium|carpal region epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003230		
GO:0080171	biolink:BiologicalProcess	lytic vacuole organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lytic vacuole.		hp.json	lytic vacuolar assembly|lytic vacuole biogenesis|lytic vacuole organisation|lytic vacuole organization and biogenesis	http://purl.obolibrary.org/obo/GO_0080171		
UBERON:0005893	biolink:AnatomicalEntity	leg bone	A bone that is part of the region of the hindlimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia. Counter-examples: any pes phalanx.	MA:0000670|EMAPA:37304|MESH:D007867	hp.json		http://purl.obolibrary.org/obo/UBERON_0005893		grouping_class
UBERON:0003231	biolink:AnatomicalEntity	epithelium of hip	An epithelium that is part of a hip [Automatically generated definition].	EHDAA:6180|EHDAA2:0000784|VHOG:0000779|EMAPA:17491|EHDAA:5155	hp.json	hip region epithelium|hip region epithelial tissue|regio coxae epithelium|epithelial tissue of hip|epithelium of regio coxae|hip epithelial tissue|hip epithelium|epithelial tissue of hip region|epithelial tissue of regio coxae|epithelium of hip region|regio coxae epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003231		
HP:0005944	biolink:PhenotypicFeature	Bilateral lung agenesis	Bilateral lack of development of the lungs.	Fyler:4206|UMLS:C4021610	hp.json	Bilateral pulmonary agenesis|Absent lungs	http://purl.obolibrary.org/obo/HP_0005944		
HP:0005945	biolink:PhenotypicFeature	Laryngeal obstruction	Blockage of the upper airway at the level of the larynx often accompanied by respiratory distress.	SNOMEDCT_US:61169001|UMLS:C0264306	hp.json		http://purl.obolibrary.org/obo/HP_0005945		
UBERON:0005891	biolink:AnatomicalEntity	coelomic epithelium	The epithelial lining of the surface of the coelom.	XAO:0000329	hp.json	germinal epithelium of Waldeyer|celomic epithelium	http://purl.obolibrary.org/obo/UBERON_0005891		
HP:0005946	biolink:PhenotypicFeature	Ventilator dependence with inability to wean		UMLS:C4025097	hp.json		http://purl.obolibrary.org/obo/HP_0005946		
HP:0005941	biolink:PhenotypicFeature	Intermittent hyperpnea at rest		UMLS:C4025098	hp.json		http://purl.obolibrary.org/obo/HP_0005941		
HP:0005942	biolink:PhenotypicFeature	Desquamative interstitial pneumonitis	Diffuse filling of the distal airsspaces of the lungs, the alveoli, with macrophages. Desquamative interstitial pneumonitis (DIP) is characterized additionally by thickend alveolar septa and by a sparse inflammatory infiltrate that often includes plasma cells and occasional eosinophils. The alveoli are lined by plump cuboidal pneumocytes. Lymphoid aggregates may be present.	MSH:C562470|UMLS:C0238378|SNOMEDCT_US:8549006	hp.json	Intra-alveolar accumulation of macrophages|Filling of the alveoli with desquamated epithelial cells|Filling of the alveoli with alveolar macrophages	http://purl.obolibrary.org/obo/HP_0005942		
UBERON:0003236	biolink:AnatomicalEntity	epithelium of lower jaw	An epithelium that is part of a lower jaw [Automatically generated definition].	EHDAA2:0001019|EHDAA:7999|VHOG:0000802|EMAPA:35516	hp.json	ventral mandibular arch epithelium|epithelium of ventral mandibular arch|epithelial tissue of ventral mandibular arch|epithelial tissue of lower jaw|ventral mandibular arch epithelial tissue|lower jaw epithelial tissue|lower jaw epithelium	http://purl.obolibrary.org/obo/UBERON_0003236		
UBERON:0005899	biolink:AnatomicalEntity	pes bone	A bone that is part of the pes skeleton.	EMAPA:35354|MA:0000643|OpenCyc:Mx4rv5ridZwpEbGdrcN5Y29ycA|MESH:D005529|UMLS:C0016505|NCIT:C13068|GAID:192	hp.json	bone of pes|bone of pedal skeleton|bone of foor proper or tarsal skeleton|bone of foot|foot bone	http://purl.obolibrary.org/obo/UBERON_0005899		
UBERON:0005897	biolink:AnatomicalEntity	manus bone	A bone that is part of the manus skeleton. Note that this includes the carpal bones.	EMAPA:35391|MA:0000619	hp.json	bone of hand skeleton|forelimb autopod bone|hand bone|bone of hand|bone of manus|bone of pectoral limb autopodium|forelimb autopodium bone|bone of pectoral limb autopod	http://purl.obolibrary.org/obo/UBERON_0005897		
UBERON:0003235	biolink:AnatomicalEntity	epithelium of upper jaw	An epithelium that is part of a upper jaw [Automatically generated definition].	EMAPA:17943|EHDAA2:0002119|EMAPA:18971|EHDAA:8027	hp.json	epithelial tissue of upper jaw|epithelium of palatoquadrate arch|upper jaw epithelial tissue|epithelial tissue of palatoquadrate arch|palatoquadrate arch epithelium|palatoquadrate arch epithelial tissue|upper jaw epithelium	http://purl.obolibrary.org/obo/UBERON_0003235		
UBERON:0003232	biolink:AnatomicalEntity	epithelium of knee	An epithelium that is part of a knee [Automatically generated definition].	EHDAA:6186|EHDAA:5161|EHDAA2:0000896|EMAPA:17494|VHOG:0000810	hp.json	knee epithelial tissue|epithelial tissue of knee|knee epithelium	http://purl.obolibrary.org/obo/UBERON_0003232		
UBERON:0003233	biolink:AnatomicalEntity	epithelium of shoulder	An epithelium that is part of a shoulder [Automatically generated definition].	EHDAA:6230|VHOG:0000761|EHDAA2:0001835|EHDAA:4182|EMAPA:17422	hp.json	epithelial tissue of shoulder|shoulder epithelial tissue|shoulder epithelium	http://purl.obolibrary.org/obo/UBERON_0003233		
CHEBI:46842	biolink:ChemicalSubstance	sarcosinium	An alpha-amino-acid cation that is the conjugate acid of sarcosine, arising from protonation of the amino group.	Gmelin:323778	hp.json	carboxy-N-methylmethanaminium	http://purl.obolibrary.org/obo/CHEBI_46842		3_STAR
UBERON:0003218	biolink:AnatomicalEntity	ovary septum	Septum that divides the ovary, the basal portion of a carpel or group of fused carpels, that encloses the ovule(s)[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0003218		
HP:0005959	biolink:PhenotypicFeature	Impaired gluconeogenesis	An impairment of gluconeogenesis.	UMLS:C3279336	hp.json	Gluconeogenesis impaired	http://purl.obolibrary.org/obo/HP_0005959		
HP:0005954	biolink:PhenotypicFeature	Pulmonary capillary hemangiomatosis		SNOMEDCT_US:233949008|UMLS:C0340548	hp.json	Pulmonary hemangiomas	http://purl.obolibrary.org/obo/HP_0005954		
UBERON:0003220	biolink:AnatomicalEntity	metanephric mesenchyme	One of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO].	EHDAA:5021|EHDAA:4041|EHDAA:5915|VHOG:0000540|EHDAA2:0004062|EMAPA:17375	hp.json	metanephros associated mesenchyme|metanephrogenic mesenchyme|metanephric blastema|metanephric mesoderm	http://purl.obolibrary.org/obo/UBERON_0003220		pheno_slim
UBERON:0005881	biolink:AnatomicalEntity	autopodial extension	A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis.		hp.json	limb outgrowth|digit or predigit	http://purl.obolibrary.org/obo/UBERON_0005881		
HP:0005956	biolink:PhenotypicFeature	Anteroposteriorly shortened larynx	Abnormal shortening of the larynx in the anteroposterior (front to back) axis.	UMLS:C3805994	hp.json		http://purl.obolibrary.org/obo/HP_0005956		
HP:0005957	biolink:PhenotypicFeature	Breathing dysregulation		UMLS:C3808046	hp.json		http://purl.obolibrary.org/obo/HP_0005957		
HP:0005950	biolink:PhenotypicFeature	Laryngeal web	A membrane-like structure that extends across the laryngeal lumen close to the level of the vocal cords.	SNOMEDCT_US:297159008|UMLS:C0281890	hp.json	Laryngeal webs|Partial laryngeal atresia	http://purl.obolibrary.org/obo/HP_0005950		
HP:0005951	biolink:PhenotypicFeature	Progressive inspiratory stridor		UMLS:C4025096	hp.json		http://purl.obolibrary.org/obo/HP_0005951		
HP:0005952	biolink:PhenotypicFeature	obsolete Decreased pulmonary function			hp.json		http://purl.obolibrary.org/obo/HP_0005952		
UBERON:0003221	biolink:AnatomicalEntity	phalanx	Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits.	UMLS:C0222682|VSAO:0000199|MA:0000304|NCIT:C33317|FMA:321661|CALOHA:TS-2211|EMAPA:32614|galen:Phalanx|OpenCyc:Mx4rvolPZpwpEbGdrcN5Y29ycA	hp.json	digit long bone|phalanx bone|phalange|phalanges|long bone of digit	http://purl.obolibrary.org/obo/UBERON_0003221		pheno_slim
UBERON:0005884	biolink:AnatomicalEntity	hyoid arch skeleton	A subdivision of skeleton that supports pharyngeal arch 2.	AAO:0010370|ZFA:0001276|AAO:0000665|XAO:0003177|TAO:0001276	hp.json	pharyngeal arch 2 skeleton|visceral arch 2|hyoid arch|hyoid arch skeleton|hyoid bars	http://purl.obolibrary.org/obo/UBERON_0005884		
GO:0031348	biolink:BiologicalProcess	negative regulation of defense response	Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.		hp.json	downregulation of defense response|down regulation of defense response|inhibition of defense response|down-regulation of defense response	http://purl.obolibrary.org/obo/GO_0031348		
GO:0031349	biolink:BiologicalProcess	positive regulation of defense response	Any process that activates or increases the frequency, rate or extent of a defense response.		hp.json	up regulation of defense response|stimulation of defense response|up-regulation of defense response|activation of defense response|upregulation of defense response	http://purl.obolibrary.org/obo/GO_0031349		
GO:0031346	biolink:BiologicalProcess	positive regulation of cell projection organization	Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.		hp.json	positive regulation of cell projection organisation|upregulation of cell projection organization|positive regulation of cell projection organization and biogenesis|up regulation of cell projection organization|stimulation of cell projection organization|up-regulation of cell projection organization|activation of cell projection organization	http://purl.obolibrary.org/obo/GO_0031346		
GO:0031347	biolink:BiologicalProcess	regulation of defense response	Any process that modulates the frequency, rate or extent of a defense response.		hp.json		http://purl.obolibrary.org/obo/GO_0031347		
GO:0045995	biolink:BiologicalProcess	regulation of embryonic development	Any process that modulates the frequency, rate or extent of embryonic development.		hp.json		http://purl.obolibrary.org/obo/GO_0045995		
GO:0045992	biolink:BiologicalProcess	negative regulation of embryonic development	Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.		hp.json	down regulation of embryonic development|downregulation of embryonic development|inhibition of embryonic development|down-regulation of embryonic development	http://purl.obolibrary.org/obo/GO_0045992		
PR:000030026	biolink:Protein	CALCA gene translation product (human)	A CALCA gene translation product that is encoded in the genome of human.		hp.json	CGRP-I (human)|CALC1 (human)|alpha-type CGRP (human)|calcitonin gene-related peptide I (human)|hCALCA	http://purl.obolibrary.org/obo/PR_000030026		
HP:0040092	biolink:PhenotypicFeature	Asymmetry of the shape of the ears		UMLS:C4022445	hp.json	Asymmetry of the shape of the ears	http://purl.obolibrary.org/obo/HP_0040092		
GO:0070956	biolink:BiologicalProcess	negative regulation of neutrophil mediated killing of bacterium	Any process that decreases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil.		hp.json	inhibition of neutrophil mediated killing of bacterium|down-regulation of neutrophil mediated killing of bacterium|downregulation of neutrophil mediated killing of bacterium|down regulation of neutrophil mediated killing of bacterium	http://purl.obolibrary.org/obo/GO_0070956		
HP:0040093	biolink:PhenotypicFeature	Asymmetry of the position of the ears		UMLS:C4022444	hp.json	Uneven ears	http://purl.obolibrary.org/obo/HP_0040093		
GO:0070954	biolink:BiologicalProcess	negative regulation of neutrophil mediated cytotoxicity	Any process that decreases the frequency, rate or extent of the directed killing of a target cell by a neutrophil.		hp.json	down-regulation of neutrophil mediated cytotoxicity|downregulation of neutrophil mediated cytotoxicity|down regulation of neutrophil mediated cytotoxicity|inhibition of neutrophil mediated cytotoxicity|negative regulation of neutrophil mediated cell killing	http://purl.obolibrary.org/obo/GO_0070954		
HP:0040090	biolink:PhenotypicFeature	Abnormality of the tympanic membrane	An abnormality of the tympanic membrane	UMLS:C4022447	hp.json	Abnormality of the eardrum	http://purl.obolibrary.org/obo/HP_0040090		
GO:0070955	biolink:BiologicalProcess	negative regulation of neutrophil mediated killing of symbiont cell	Any process that decreases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil.		hp.json	downregulation of neutrophil mediated killing of symbiont cell|down regulation of neutrophil mediated killing of symbiont cell|inhibition of neutrophil mediated killing of symbiont cell|down-regulation of neutrophil mediated killing of symbiont cell	http://purl.obolibrary.org/obo/GO_0070955		
HP:0040091	biolink:PhenotypicFeature	Asymmetry of the size of ears		UMLS:C4022446	hp.json	Asymmetry of the size of ears	http://purl.obolibrary.org/obo/HP_0040091		
GO:0031344	biolink:BiologicalProcess	regulation of cell projection organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.		hp.json	regulation of cell projection organization and biogenesis|regulation of cell projection organisation	http://purl.obolibrary.org/obo/GO_0031344		
HP:0040096	biolink:PhenotypicFeature	Neoplasm of the inner ear	A tumor (abnormal growth of tissue) of the inner ear.	UMLS:C1512779|NCIT:C3262	hp.json	Inner ear tumour|Inner ear tumor	http://purl.obolibrary.org/obo/HP_0040096		
HP:0040097	biolink:PhenotypicFeature	Neoplasm of the ceruminal gland	A tumor (abnormal growth of tissue) of the ceruminal gland.	SNOMEDCT_US:52707009|SNOMEDCT_US:403945001|NCIT:C3262|UMLS:C0334352	hp.json	Adenoma of the ceruminous gland|Ceruminous adenoma|Ceruminoma	http://purl.obolibrary.org/obo/HP_0040097		
GO:0031345	biolink:BiologicalProcess	negative regulation of cell projection organization	Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.		hp.json	inhibition of cell projection organization|down-regulation of cell projection organization|down regulation of cell projection organization|negative regulation of cell projection organization and biogenesis|downregulation of cell projection organization|negative regulation of cell projection organisation	http://purl.obolibrary.org/obo/GO_0031345		
GO:0031342	biolink:BiologicalProcess	negative regulation of cell killing	Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing.		hp.json	down regulation of cell killing|inhibition of cell killing|down-regulation of cell killing|downregulation of cell killing	http://purl.obolibrary.org/obo/GO_0031342		
GO:0070950	biolink:BiologicalProcess	regulation of neutrophil mediated killing of bacterium	Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a bacterium, the directed killing of a bacterium by a neutrophil.		hp.json		http://purl.obolibrary.org/obo/GO_0070950		
HP:0040095	biolink:PhenotypicFeature	Neoplasm of the outer ear	A tumor (abnormal growth of tissue) of the outer ear.	UMLS:C4022443|NCIT:C3262	hp.json	Outer ear tumour|Outer ear tumor	http://purl.obolibrary.org/obo/HP_0040095		
GO:0031343	biolink:BiologicalProcess	positive regulation of cell killing	Any process that activates or increases the frequency, rate or extent of cell killing.		hp.json	upregulation of cell killing|up regulation of cell killing|stimulation of cell killing|activation of cell killing|up-regulation of cell killing	http://purl.obolibrary.org/obo/GO_0031343		
GO:0031340	biolink:BiologicalProcess	positive regulation of vesicle fusion	Any process that activates or increases the frequency, rate or extent of vesicle fusion.		hp.json	up regulation of vesicle fusion|stimulation of vesicle fusion|up-regulation of vesicle fusion|activation of vesicle fusion|upregulation of vesicle fusion	http://purl.obolibrary.org/obo/GO_0031340		
GO:0031341	biolink:BiologicalProcess	regulation of cell killing	Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.		hp.json		http://purl.obolibrary.org/obo/GO_0031341		
HP:0040098	biolink:PhenotypicFeature	Basalioma of the outer ear		UMLS:C4022442	hp.json		http://purl.obolibrary.org/obo/HP_0040098		
HP:0040099	biolink:PhenotypicFeature	Abnormality of the round window		UMLS:C4022441	hp.json		http://purl.obolibrary.org/obo/HP_0040099		
GO:0031339	biolink:BiologicalProcess	negative regulation of vesicle fusion	Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion.		hp.json	inhibition of vesicle fusion|down-regulation of vesicle fusion|downregulation of vesicle fusion|down regulation of vesicle fusion	http://purl.obolibrary.org/obo/GO_0031339		
GO:0031337	biolink:BiologicalProcess	positive regulation of sulfur amino acid metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.		hp.json	upregulation of sulfur amino acid metabolic process|up-regulation of sulfur amino acid metabolic process|up regulation of sulfur amino acid metabolic process|activation of sulfur amino acid metabolic process|positive regulation of sulfur amino acid metabolism|stimulation of sulfur amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0031337		
GO:0031338	biolink:BiologicalProcess	regulation of vesicle fusion	Any process that modulates the frequency, rate or extent of vesicle fusion.		hp.json		http://purl.obolibrary.org/obo/GO_0031338		
GO:0031335	biolink:BiologicalProcess	regulation of sulfur amino acid metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.		hp.json	regulation of sulfur amino acid metabolism	http://purl.obolibrary.org/obo/GO_0031335		
GO:0031336	biolink:BiologicalProcess	negative regulation of sulfur amino acid metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.		hp.json	down-regulation of sulfur amino acid metabolic process|down regulation of sulfur amino acid metabolic process|downregulation of sulfur amino acid metabolic process|inhibition of sulfur amino acid metabolic process|negative regulation of sulfur amino acid metabolism	http://purl.obolibrary.org/obo/GO_0031336		
PR:000029032	biolink:Protein	Mus musculus protein	A protein that is encoded in the genome of Mus musculus.		hp.json	mouse protein	http://purl.obolibrary.org/obo/PR_000029032		
GO:0070949	biolink:BiologicalProcess	regulation of neutrophil mediated killing of symbiont cell	Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a symbiont cell, the directed killing of a symbiont target cell by a neutrophil.		hp.json		http://purl.obolibrary.org/obo/GO_0070949		
GO:0070948	biolink:BiologicalProcess	regulation of neutrophil mediated cytotoxicity	Any process that modulates the rate, frequency or extent of neutrophil mediated killing of a target cell, the directed killing of a target cell by a neutrophil.		hp.json	regulation of neutrophil mediated cell killing	http://purl.obolibrary.org/obo/GO_0070948		
GO:0070943	biolink:BiologicalProcess	neutrophil-mediated killing of symbiont cell	The directed killing of a symbiont target cell by a neutrophil. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.		hp.json	neutrophil mediated killing of symbiont cell	http://purl.obolibrary.org/obo/GO_0070943		
GO:0070944	biolink:BiologicalProcess	neutrophil-mediated killing of bacterium	The directed killing of a bacterium by a neutrophil.		hp.json	neutrophil mediated killing of bacterium	http://purl.obolibrary.org/obo/GO_0070944		
GO:0031333	biolink:BiologicalProcess	negative regulation of protein-containing complex assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.		hp.json	downregulation of protein complex assembly|down regulation of protein complex assembly|inhibition of protein complex assembly|down-regulation of protein complex assembly|negative regulation of protein complex assembly	http://purl.obolibrary.org/obo/GO_0031333		
GO:0031334	biolink:BiologicalProcess	positive regulation of protein-containing complex assembly	Any process that activates or increases the frequency, rate or extent of protein complex assembly.		hp.json	stimulation of protein complex assembly|up-regulation of protein complex assembly|positive regulation of protein complex assembly|activation of protein complex assembly|upregulation of protein complex assembly|up regulation of protein complex assembly	http://purl.obolibrary.org/obo/GO_0031334		
GO:0070942	biolink:BiologicalProcess	neutrophil mediated cytotoxicity	The directed killing of a target cell by a neutrophil.		hp.json	neutrophil mediated cell killing	http://purl.obolibrary.org/obo/GO_0070942		
GO:0031331	biolink:BiologicalProcess	positive regulation of cellular catabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.		hp.json	upregulation of cellular catabolic process|positive regulation of cellular breakdown|up regulation of cellular catabolic process|stimulation of cellular catabolic process|up-regulation of cellular catabolic process|activation of cellular catabolic process|positive regulation of cellular catabolism|positive regulation of cellular degradation	http://purl.obolibrary.org/obo/GO_0031331		
GO:0033993	biolink:BiologicalProcess	response to lipid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0033993		
GO:0031330	biolink:BiologicalProcess	negative regulation of cellular catabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.		hp.json	down regulation of cellular catabolic process|negative regulation of cellular catabolism|inhibition of cellular catabolic process|down-regulation of cellular catabolic process|negative regulation of cellular degradation|downregulation of cellular catabolic process|negative regulation of cellular breakdown	http://purl.obolibrary.org/obo/GO_0031330		
GO:0031328	biolink:BiologicalProcess	positive regulation of cellular biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.		hp.json	up-regulation of cellular biosynthetic process|positive regulation of cellular anabolism|up regulation of cellular biosynthetic process|activation of cellular biosynthetic process|positive regulation of cellular biosynthesis|positive regulation of cellular synthesis|stimulation of cellular biosynthetic process|positive regulation of cellular formation|upregulation of cellular biosynthetic process	http://purl.obolibrary.org/obo/GO_0031328		
GO:0031329	biolink:BiologicalProcess	regulation of cellular catabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.		hp.json	regulation of cellular breakdown|regulation of cellular degradation|regulation of cellular catabolism	http://purl.obolibrary.org/obo/GO_0031329		
GO:0031326	biolink:BiologicalProcess	regulation of cellular biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.		hp.json	regulation of cellular anabolism|regulation of cellular synthesis|regulation of cellular biosynthesis|regulation of cellular formation	http://purl.obolibrary.org/obo/GO_0031326		
GO:0031327	biolink:BiologicalProcess	negative regulation of cellular biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.		hp.json	downregulation of cellular biosynthetic process|inhibition of cellular biosynthetic process|negative regulation of cellular synthesis|negative regulation of cellular formation|down-regulation of cellular biosynthetic process|negative regulation of cellular biosynthesis|down regulation of cellular biosynthetic process|negative regulation of cellular anabolism	http://purl.obolibrary.org/obo/GO_0031327		
GO:0031324	biolink:BiologicalProcess	negative regulation of cellular metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.		hp.json	inhibition of cellular metabolic process|down-regulation of cellular metabolic process|downregulation of cellular metabolic process|negative regulation of cellular metabolism|down regulation of cellular metabolic process	http://purl.obolibrary.org/obo/GO_0031324		gocheck_do_not_annotate
GO:0031325	biolink:BiologicalProcess	positive regulation of cellular metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.		hp.json	upregulation of cellular metabolic process|up regulation of cellular metabolic process|positive regulation of cellular metabolism|stimulation of cellular metabolic process|up-regulation of cellular metabolic process|activation of cellular metabolic process	http://purl.obolibrary.org/obo/GO_0031325		gocheck_do_not_annotate
CHEBI:189840	biolink:ChemicalSubstance	dicarboxylic fatty acid	Any fatty acid containing two carboxy groups.		hp.json		http://purl.obolibrary.org/obo/CHEBI_189840		2_STAR
GO:0043354	biolink:BiologicalProcess	enucleate erythrocyte maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus.		hp.json	enucleate red blood cell maturation|enucleate RBC maturation	http://purl.obolibrary.org/obo/GO_0043354		
GO:0043353	biolink:BiologicalProcess	enucleate erythrocyte differentiation	The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.		hp.json	enucleate red blood cell differentiation|enucleate RBC differentiation	http://purl.obolibrary.org/obo/GO_0043353		
CHEBI:189846	biolink:ChemicalSubstance	dicarboxylic fatty acid dianion	Any fatty acid that contains 2 carboxylic groups. Major microspecies at pH 7.3		hp.json	a dicarboxylic fatty acid	http://purl.obolibrary.org/obo/CHEBI_189846		2_STAR
GO:0070977	biolink:BiologicalProcess	bone maturation	A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state.		hp.json		http://purl.obolibrary.org/obo/GO_0070977		
GO:0031323	biolink:BiologicalProcess	regulation of cellular metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.		hp.json	regulation of cellular metabolism	http://purl.obolibrary.org/obo/GO_0031323		gocheck_do_not_annotate
GO:0021990	biolink:BiologicalProcess	neural plate formation	The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0021990		
PR:000005061	biolink:Protein	catalase	A protein that is a translation product of the human CAT gene or a 1:1 ortholog thereof.		hp.json	CAT|Cas1|Cas-1	http://purl.obolibrary.org/obo/PR_000005061		
GO:0043362	biolink:BiologicalProcess	nucleate erythrocyte maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus.		hp.json	nucleate red blood cell maturation|nucleate RBC maturation	http://purl.obolibrary.org/obo/GO_0043362		
GO:0043363	biolink:BiologicalProcess	nucleate erythrocyte differentiation	The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds.		hp.json	nucleate red blood cell differentiation|nucleate RBC differentiation	http://purl.obolibrary.org/obo/GO_0043363		
GO:0070961	biolink:BiologicalProcess	positive regulation of neutrophil mediated killing of symbiont cell	Any process that increases the frequency, rate or extent of the directed killing of a symbiont target cell by a neutrophil.		hp.json	up-regulation of neutrophil mediated killing of symbiont cell|activation of neutrophil mediated killing of symbiont cell|upregulation of neutrophil mediated killing of symbiont cell|stimulation of neutrophil mediated killing of symbiont cell|up regulation of neutrophil mediated killing of symbiont cell	http://purl.obolibrary.org/obo/GO_0070961		
GO:0070962	biolink:BiologicalProcess	positive regulation of neutrophil mediated killing of bacterium	Any process that increases the frequency, rate or extent of the directed killing of a bacterium by a neutrophil.		hp.json	up regulation of neutrophil mediated killing of bacterium|stimulation of neutrophil mediated killing of bacterium|up-regulation of neutrophil mediated killing of bacterium|activation of neutrophil mediated killing of bacterium|upregulation of neutrophil mediated killing of bacterium	http://purl.obolibrary.org/obo/GO_0070962		
GO:0021999	biolink:BiologicalProcess	neural plate anterior/posterior regionalization	The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.		hp.json	neural plate anterior/posterior pattern formation	http://purl.obolibrary.org/obo/GO_0021999		
GO:0070960	biolink:BiologicalProcess	positive regulation of neutrophil mediated cytotoxicity	Any process that increases the frequency, rate or extent of the directed killing of a target cell by a neutrophil.		hp.json	up regulation of neutrophil mediated cytotoxicity|stimulation of neutrophil mediated cytotoxicity|up-regulation of neutrophil mediated cytotoxicity|activation of neutrophil mediated cytotoxicity|upregulation of neutrophil mediated cytotoxicity|positive regulation of neutrophil mediated cell killing	http://purl.obolibrary.org/obo/GO_0070960		
HP:0040059	biolink:PhenotypicFeature	Calcification of ribs		UMLS:C4022461	hp.json		http://purl.obolibrary.org/obo/HP_0040059		
HGNC:6720	biolink:Gene	LTF (human)	A protein coding gene LTF in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6720		
HP:0040052	biolink:PhenotypicFeature	Abnormality of lower eyelashes		UMLS:C4022466	hp.json	Abnormality of lower eyelashes	http://purl.obolibrary.org/obo/HP_0040052		
HP:0040053	biolink:PhenotypicFeature	Long lower eyelashes		UMLS:C4022465	hp.json	Increased length of lower eyelashes|Long lower eyelashes|Ciliary trichomegaly of lower eyelashes	http://purl.obolibrary.org/obo/HP_0040053		
GO:0070997	biolink:BiologicalProcess	neuron death	The process of cell death in a neuron.		hp.json	neuron cell death|neuronal cell death	http://purl.obolibrary.org/obo/GO_0070997		
HP:0040050	biolink:PhenotypicFeature	Sparse upper eyelashes		UMLS:C4022468	hp.json	Sparse upper eyelashes|Hypotrichosis of upper eyelashes|Partial absence of upper eyelashes	http://purl.obolibrary.org/obo/HP_0040050		
GO:0021987	biolink:BiologicalProcess	cerebral cortex development	The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.		hp.json	neocortex development|corticogenesis	http://purl.obolibrary.org/obo/GO_0021987		
HP:0040051	biolink:PhenotypicFeature	Abnormality of upper eyelashes		UMLS:C4022467	hp.json	Abnormality of upper eyelashes	http://purl.obolibrary.org/obo/HP_0040051		
HP:0040056	biolink:PhenotypicFeature	Absent upper eyelashes		UMLS:C4280255|UMLS:C4280294|UMLS:C4022462	hp.json	Failure of development of upper eyelashes|Atrichia of upper eyelashes|Agenesis of upper eyelashes|Aplasia of upper eyelashes|Absent upper eyelashes	http://purl.obolibrary.org/obo/HP_0040056		
HP:0040057	biolink:PhenotypicFeature	Abnormality of nasal hair		UMLS:C4021858	hp.json	Abnormality of nose hair|Abnormality of nasal hair	http://purl.obolibrary.org/obo/HP_0040057		
HP:0040054	biolink:PhenotypicFeature	Short upper eyelashes		UMLS:C4022464	hp.json	Short upper eyelashes|Decreased length of upper eyelashes	http://purl.obolibrary.org/obo/HP_0040054		
HP:0040055	biolink:PhenotypicFeature	Short lower eyelashes		UMLS:C4022463	hp.json	Short lower eyelashes|Decreased length of lower eyelashes	http://purl.obolibrary.org/obo/HP_0040055		
HP:0040069	biolink:PhenotypicFeature	Abnormal lower limb bone morphology		UMLS:C4022457|UMLS:C4022455	hp.json	Abnormal morphology of bones of the lower limbs|Abnormal shape of bones of the lower limbs|Abnormality of lower limb bone	http://purl.obolibrary.org/obo/HP_0040069		
HP:0040063	biolink:PhenotypicFeature	Decreased adipose tissue		UMLS:C4022459	hp.json	Decreased fat tissue	http://purl.obolibrary.org/obo/HP_0040063		
HP:0040064	biolink:PhenotypicFeature	Abnormality of limbs		SNOMEDCT_US:445144002|UMLS:C4073131|UMLS:C0239337	hp.json	Abnormal limbs|Limb anomaly|Abnormality of limbs|Dysmelia	http://purl.obolibrary.org/obo/HP_0040064		
HP:0040061	biolink:PhenotypicFeature	Osteosclerosis of the radius		UMLS:C4022460	hp.json		http://purl.obolibrary.org/obo/HP_0040061		
HP:0040062	biolink:PhenotypicFeature	Slender radius		UMLS:C1968813	hp.json		http://purl.obolibrary.org/obo/HP_0040062		
HP:0040068	biolink:PhenotypicFeature	Abnormality of limb bone		UMLS:C4022456	hp.json	Abnormality of limb bone	http://purl.obolibrary.org/obo/HP_0040068		
HP:0040065	biolink:PhenotypicFeature	obsolete Abnormal morphology of bones of the upper limbs			hp.json		http://purl.obolibrary.org/obo/HP_0040065		
HP:0040066	biolink:PhenotypicFeature	obsolete Abnormal morphology of bones of the lower limbs			hp.json		http://purl.obolibrary.org/obo/HP_0040066		
GO:0043393	biolink:BiologicalProcess	regulation of protein binding	Any process that modulates the frequency, rate or extent of protein binding.		hp.json		http://purl.obolibrary.org/obo/GO_0043393		
GO:0006325	biolink:BiologicalProcess	chromatin organization	Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.		hp.json	establishment or maintenance of chromatin architecture|chromatin organisation|chromatin modification|chromatin assembly/disassembly|chromatin assembly or disassembly	http://purl.obolibrary.org/obo/GO_0006325		goslim_pombe|goslim_yeast|goslim_generic
PR:000029067	biolink:Protein	Homo sapiens protein	A protein that is encoded in the genome of Homo sapiens.		hp.json	human protein	http://purl.obolibrary.org/obo/PR_000029067		
HP:0040070	biolink:PhenotypicFeature	Abnormal upper limb bone morphology		UMLS:C4022454|UMLS:C4022458	hp.json	Abnormality of upper limb bone|Abnormal morphology of bones of the upper limbs|Abnormal shape of bones of the upper limbs	http://purl.obolibrary.org/obo/HP_0040070		
HP:0040071	biolink:PhenotypicFeature	Abnormal morphology of ulna	Any structural anomaly of the ulna, a bone of the forearm the extends from the elbow to the little finger.	UMLS:C4022453	hp.json		http://purl.obolibrary.org/obo/HP_0040071		
HP:0040075	biolink:PhenotypicFeature	Hypopituitarism		UMLS:C0020635|MSH:D007018|SNOMEDCT_US:74728003	hp.json		http://purl.obolibrary.org/obo/HP_0040075		
HP:0040072	biolink:PhenotypicFeature	Abnormal forearm bone morphology		UMLS:C4022452	hp.json	Abnormality of forearm bone	http://purl.obolibrary.org/obo/HP_0040072		
HP:0040073	biolink:PhenotypicFeature	Obsolete Abnormal forearm bone morphology			hp.json		http://purl.obolibrary.org/obo/HP_0040073		
HP:0040078	biolink:PhenotypicFeature	Axonal degeneration		UMLS:C1837496	hp.json		http://purl.obolibrary.org/obo/HP_0040078		
HP:0040079	biolink:PhenotypicFeature	Irregular dentition		UMLS:C1856765	hp.json	Irregular teeth	http://purl.obolibrary.org/obo/HP_0040079		
HP:0040077	biolink:PhenotypicFeature	obsolete Abnormal concentration of calcium in blood			hp.json		http://purl.obolibrary.org/obo/HP_0040077		
PR:000030035	biolink:Protein	G-protein coupled receptor	A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.	IUPHARfam:694	hp.json	fam:GPCR|seven-transmembrane receptor|7TM receptor	http://purl.obolibrary.org/obo/PR_000030035		
HP:0040081	biolink:PhenotypicFeature	Abnormal circulating creatine kinase concentration	Any deviation from the normal circulating creatine kinase concentration.	UMLS:C4022449	hp.json	Abnormal circulating CPK concentration|Abnormal levels of creatine kinase in blood|Abnormal circulation phospho-CK concentration|Abnormal circulating CK concentration	http://purl.obolibrary.org/obo/HP_0040081		
HP:0040082	biolink:PhenotypicFeature	Happy demeanor	A conspicuously happy disposition with frequent smiling and laughing that may be context-inappropriate or unrelated to context.	UMLS:C1856115	hp.json	Happy demeanor|Happy demeanour	http://purl.obolibrary.org/obo/HP_0040082		
HP:0040080	biolink:PhenotypicFeature	Anteverted ears		UMLS:C1857055	hp.json		http://purl.obolibrary.org/obo/HP_0040080		
HP:0040085	biolink:PhenotypicFeature	Abnormal circulating aldosterone		UMLS:C0857898	hp.json	Abnormal circulating aldosterone|Abnormal plasma aldosterone	http://purl.obolibrary.org/obo/HP_0040085		
HP:0040086	biolink:PhenotypicFeature	Abnormal prolactin level		UMLS:C4022448	hp.json	Abnormal prolactin level	http://purl.obolibrary.org/obo/HP_0040086		
GO:0021953	biolink:BiologicalProcess	central nervous system neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0021953		
GO:0021954	biolink:BiologicalProcess	central nervous system neuron development	The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.		hp.json		http://purl.obolibrary.org/obo/GO_0021954		
HP:0040083	biolink:PhenotypicFeature	obsolete Toe walking	Toe walking is a pattern of walking in which a person walks on balls of his or her feet, with no contact between the heels and ground. Toe-walking is common in children who are learning to walk, but most children outgrow it around the age of two years. This term refers to the persistance of toe-walking beyond the usual age.		hp.json		http://purl.obolibrary.org/obo/HP_0040083		
HP:0040084	biolink:PhenotypicFeature	Abnormal circulating renin	A deviation from the normal concentration of renin in the blood, a central hormone in the control of blood pressure and various other physiological functions.	UMLS:C4021038	hp.json	Abnormal circulating renin|Abnormal plasma renin	http://purl.obolibrary.org/obo/HP_0040084		
HP:0040089	biolink:PhenotypicFeature	Abnormal natural killer cell count	Any deviation from the normal overall count of natural killer (NK) cells in the circulation or a deviation from the normal distribution of NK cell subtypes.	UMLS:C4021036	hp.json	Abnormality of natural killer cell count|Abnormal number of natural killer cells|Abnormal NK cell count	http://purl.obolibrary.org/obo/HP_0040089		
HP:0040087	biolink:PhenotypicFeature	Abnormal blood folate concentration	Any deviation from the normal concentration of folate in the blood circulation.	UMLS:C4021037	hp.json	Abnormality of folate in blood|Abnormal serum folate	http://purl.obolibrary.org/obo/HP_0040087		
HP:0040088	biolink:PhenotypicFeature	Abnormal lymphocyte count	Any abnormality in the total number of lymphocytes in the blood.	UMLS:C0580550|SNOMEDCT_US:165534000	hp.json	Abnormal numbers of lymphocytes|Abnormal lymphocyte counts|Abnormality of lymphocyte number|Abnormal number of lymphocytes|Abnormal lymphocyte count	http://purl.obolibrary.org/obo/HP_0040088		
HP:0040016	biolink:PhenotypicFeature	Prominent coccyx		UMLS:C4022490	hp.json	Prominent tailbone	http://purl.obolibrary.org/obo/HP_0040016		
HP:0040017	biolink:PhenotypicFeature	Protruding coccyx		UMLS:C4022489	hp.json	Protruding tailbone	http://purl.obolibrary.org/obo/HP_0040017		
HP:0040014	biolink:PhenotypicFeature	Increased mitochondrial number		UMLS:C4022492	hp.json		http://purl.obolibrary.org/obo/HP_0040014		
HP:0040015	biolink:PhenotypicFeature	Increased activity of mitochondrial respiratory chain		UMLS:C4022491	hp.json		http://purl.obolibrary.org/obo/HP_0040015		
HP:0003070	biolink:PhenotypicFeature	Elbow ankylosis		SNOMEDCT_US:202307002|UMLS:C0409477	hp.json		http://purl.obolibrary.org/obo/HP_0003070		
HP:0040018	biolink:PhenotypicFeature	Clinodactyly of hallux		UMLS:C4280299|UMLS:C4022488	hp.json	Curvature of big toe	http://purl.obolibrary.org/obo/HP_0040018		
HP:0040019	biolink:PhenotypicFeature	Finger clinodactyly		SNOMEDCT_US:17268007|UMLS:C0265610|UMLS:C4280298	hp.json	Curvature of finger	http://purl.obolibrary.org/obo/HP_0040019		
NBO:0001786	biolink:NamedThing	regulation of behavior	"Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [GO:0050795]		hp.json		http://purl.obolibrary.org/obo/NBO_0001786		
HP:0030693	biolink:PhenotypicFeature	Supratentorial neoplasm	A benign or malignant neoplasm that occurs within the intracranial cavity above the tentorium cerebelli.	SNOMEDCT_US:359619007|SNOMEDCT_US:47598005|UMLS:C0038874|MSH:D015173|SNOMEDCT_US:127026004|UMLS:C0031941|NCIT:C3328|MSH:D010871	hp.json	Pineal parenchymal tumor|Pineal parenchymal tumour	http://purl.obolibrary.org/obo/HP_0030693		
HP:0030694	biolink:PhenotypicFeature	Pineal parenchymal cell neoplasm		SNOMEDCT_US:47598005|SNOMEDCT_US:359619007|UMLS:C0031941|SNOMEDCT_US:127026004|MSH:D010871	hp.json		http://purl.obolibrary.org/obo/HP_0030694		
HP:0030690	biolink:PhenotypicFeature	Gingival cleft	A fissure in the gingiva (gums), i.e., the mucosal tissue that lies over the mandible and maxilla.	UMLS:C0426489|SNOMEDCT_US:109622003	hp.json		http://purl.obolibrary.org/obo/HP_0030690		
HP:0030691	biolink:PhenotypicFeature	Divergence nystagmus	A condition in which both eyes beat outward simultaneously.	UMLS:C4073130	hp.json		http://purl.obolibrary.org/obo/HP_0030691		
HP:0030692	biolink:PhenotypicFeature	Brain neoplasm	A benign or malignant neoplasm that arises from or metastasizes to the brain.	NCIT:C2907|MSH:D001932|SNOMEDCT_US:254935002|SNOMEDCT_US:126952004|UMLS:C0006118	hp.json	Brain tumour|Brain tumor	http://purl.obolibrary.org/obo/HP_0030692		
GO:0045916	biolink:BiologicalProcess	negative regulation of complement activation	Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation.		hp.json	down-regulation of complement activation|down regulation of complement activation|downregulation of complement activation|inhibition of complement activation|negative regulation of complement cascade	http://purl.obolibrary.org/obo/GO_0045916		
GO:0045917	biolink:BiologicalProcess	positive regulation of complement activation	Any process that activates or increases the frequency, rate or extent of complement activation.		hp.json	activation of complement activation|stimulation of complement activation|positive regulation of complement cascade|upregulation of complement activation|up-regulation of complement activation|up regulation of complement activation	http://purl.obolibrary.org/obo/GO_0045917		
GO:0045914	biolink:BiologicalProcess	negative regulation of catecholamine metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.		hp.json	down regulation of catecholamine metabolic process|negative regulation of catecholamine metabolism|downregulation of catecholamine metabolic process|inhibition of catecholamine metabolic process|down-regulation of catecholamine metabolic process	http://purl.obolibrary.org/obo/GO_0045914		
HP:0003068	biolink:PhenotypicFeature	Madelung-like forearm deformities		UMLS:C1851419	hp.json		http://purl.obolibrary.org/obo/HP_0003068		
GO:0045915	biolink:BiologicalProcess	positive regulation of catecholamine metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catecholamine.		hp.json	up-regulation of catecholamine metabolic process|positive regulation of catecholamine metabolism|up regulation of catecholamine metabolic process|activation of catecholamine metabolic process|stimulation of catecholamine metabolic process|upregulation of catecholamine metabolic process	http://purl.obolibrary.org/obo/GO_0045915		
GO:0045912	biolink:BiologicalProcess	negative regulation of carbohydrate metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.		hp.json	inhibition of carbohydrate metabolic process|down-regulation of carbohydrate metabolic process|downregulation of carbohydrate metabolic process|negative regulation of carbohydrate metabolism|down regulation of carbohydrate metabolic process	http://purl.obolibrary.org/obo/GO_0045912		
GO:0045913	biolink:BiologicalProcess	positive regulation of carbohydrate metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving carbohydrate.		hp.json	upregulation of carbohydrate metabolic process|up regulation of carbohydrate metabolic process|stimulation of carbohydrate metabolic process|positive regulation of carbohydrate metabolism|up-regulation of carbohydrate metabolic process|activation of carbohydrate metabolic process	http://purl.obolibrary.org/obo/GO_0045913		
HP:0003063	biolink:PhenotypicFeature	Abnormality of the humerus	An abnormality of the humerus (i.e., upper arm bone).	UMLS:C4021742	hp.json	Abnormality of the humeri	http://purl.obolibrary.org/obo/HP_0003063		
HP:0040012	biolink:PhenotypicFeature	Chromosome breakage	Elevated rate of chromosomal breakage or interchanges occurring either spontaneously or following exposure to various DNA-damaging agents. This feature may be assayed by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents.	MSH:D019457|UMLS:C0376628	hp.json	Multiple chromosomal breaks|Increased chromosomal breakage rate|Increased chromosomal breakage|High frequency of chromosome breaks in lymphocytes|Tendency to chromosomal breakage	http://purl.obolibrary.org/obo/HP_0040012		
HP:0003067	biolink:PhenotypicFeature	Madelung deformity	An anomaly related to partial closure, or failure of development of the ulnar side of the distal radial growth plate, which results in an arrest of epiphyseal growth of the medial and volar portions of the distal radius. This leads to shortening of the radius and relative overgrowth of the ulna.	MSH:C562398|SNOMEDCT_US:4530000|UMLS:C0152441	hp.json	Madelung wrist deformity	http://purl.obolibrary.org/obo/HP_0003067		hposlim_core
HP:0040013	biolink:PhenotypicFeature	Decreased mitochondrial number		UMLS:C4022493	hp.json		http://purl.obolibrary.org/obo/HP_0040013		
HP:0003066	biolink:PhenotypicFeature	Limited knee extension	Reduced ability to extend (straighten) the knee joint.	UMLS:C1844690	hp.json	Limited knee extension	http://purl.obolibrary.org/obo/HP_0003066		
HP:0003065	biolink:PhenotypicFeature	Patellar hypoplasia	Underdevelopment of the patella.	UMLS:C1840068	hp.json	Small patellae|Small kneecap|Underdeveloped kneecap|Hypoplastic patellae|Small patella	http://purl.obolibrary.org/obo/HP_0003065		
HP:0040010	biolink:PhenotypicFeature	Small posterior fossa		UMLS:C4022496	hp.json		http://purl.obolibrary.org/obo/HP_0040010		
HP:0040011	biolink:PhenotypicFeature	Flat posterior fossa		UMLS:C4022495	hp.json		http://purl.obolibrary.org/obo/HP_0040011		
HP:0040025	biolink:PhenotypicFeature	Clinodactyly of the 4th finger		UMLS:C4022484|UMLS:C4280295	hp.json	Curvature of ring finger	http://purl.obolibrary.org/obo/HP_0040025		
HP:0003081	biolink:PhenotypicFeature	Increased urinary potassium	An increased concentration of potassium(1+) in the urine.	UMLS:C1846351	hp.json	Increased urinary K|Hyperkaliuresis|Increased urinary potassium	http://purl.obolibrary.org/obo/HP_0003081		
HP:0003080	biolink:PhenotypicFeature	Hydroxyprolinuria	An increased concentration of 4-hydroxy-L-proline in the urine.	UMLS:C0948585	hp.json	Elevated urinary hydroxyproline	http://purl.obolibrary.org/obo/HP_0003080		
GO:0045920	biolink:BiologicalProcess	negative regulation of exocytosis	Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.		hp.json	down regulation of exocytosis|inhibition of exocytosis|down-regulation of exocytosis|downregulation of exocytosis	http://purl.obolibrary.org/obo/GO_0045920		
GO:0045927	biolink:BiologicalProcess	positive regulation of growth	Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism.		hp.json	upregulation of growth|up regulation of growth|stimulation of growth|up-regulation of growth|activation of growth	http://purl.obolibrary.org/obo/GO_0045927		
HP:0003079	biolink:PhenotypicFeature	Defective DNA repair after ultraviolet radiation damage		UMLS:C1968564	hp.json		http://purl.obolibrary.org/obo/HP_0003079		
GO:0045926	biolink:BiologicalProcess	negative regulation of growth	Any process that stops, prevents or reduces the rate or extent of growth, the increase in size or mass of all or part of an organism.		hp.json	downregulation of growth|down regulation of growth|inhibition of growth|down-regulation of growth	http://purl.obolibrary.org/obo/GO_0045926		
GO:0045923	biolink:BiologicalProcess	positive regulation of fatty acid metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.		hp.json	positive regulation of fatty acid metabolism|upregulation of fatty acid metabolic process|up regulation of fatty acid metabolic process|stimulation of fatty acid metabolic process|activation of fatty acid metabolic process|up-regulation of fatty acid metabolic process	http://purl.obolibrary.org/obo/GO_0045923		
GO:0045921	biolink:BiologicalProcess	positive regulation of exocytosis	Any process that activates or increases the frequency, rate or extent of exocytosis.		hp.json	upregulation of exocytosis|stimulation of exocytosis|up regulation of exocytosis|up-regulation of exocytosis|activation of exocytosis	http://purl.obolibrary.org/obo/GO_0045921		
GO:0045922	biolink:BiologicalProcess	negative regulation of fatty acid metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.		hp.json	inhibition of fatty acid metabolic process|down-regulation of fatty acid metabolic process|negative regulation of fatty acid metabolism|downregulation of fatty acid metabolic process|down regulation of fatty acid metabolic process	http://purl.obolibrary.org/obo/GO_0045922		
HP:0003074	biolink:PhenotypicFeature	Hyperglycemia	An increased concentration of glucose in the blood.	UMLS:C0020456|MSH:D006943|SNOMEDCT_US:80394007|SNOMEDCT_US:237598005	hp.json	High blood sugar|High blood glucose	http://purl.obolibrary.org/obo/HP_0003074		
HP:0003073	biolink:PhenotypicFeature	Hypoalbuminemia	Reduction in the concentration of albumin in the blood.	MSH:D034141|SNOMEDCT_US:119247004|UMLS:C0239981	hp.json	Hypoalbuminaemia|Low blood albumin|Low albumin	http://purl.obolibrary.org/obo/HP_0003073		
HP:0040020	biolink:PhenotypicFeature	Radial deviation of the 5th finger		UMLS:C4022487	hp.json		http://purl.obolibrary.org/obo/HP_0040020		
HP:0003072	biolink:PhenotypicFeature	Hypercalcemia	An abnormally increased calcium concentration in the blood.	SNOMEDCT_US:66931009|SNOMEDCT_US:166702002|UMLS:C0020437|MSH:D006934	hp.json	Hypercalcaemia|High blood calcium levels|Increased calcium in blood	http://purl.obolibrary.org/obo/HP_0003072		
HP:0003071	biolink:PhenotypicFeature	Flattened epiphysis	Abnormal flatness (decreased height) of epiphyses.	UMLS:C1857527	hp.json	Flat epiphyses|Flat end part of bone	http://purl.obolibrary.org/obo/HP_0003071		
HP:0040023	biolink:PhenotypicFeature	Clinodactyly of the thumb		UMLS:C1856888|UMLS:C4280297	hp.json	Curvature of thumb	http://purl.obolibrary.org/obo/HP_0040023		
HP:0040024	biolink:PhenotypicFeature	Clinodactyly of the 3rd finger		UMLS:C4280296|UMLS:C4022485	hp.json	Curvature of middle finger	http://purl.obolibrary.org/obo/HP_0040024		
HP:0003077	biolink:PhenotypicFeature	Hyperlipidemia	An elevated lipid concentration in the blood.	UMLS:C0020473|MSH:D006949|SNOMEDCT_US:55822004	hp.json	Elevated lipids in blood	http://purl.obolibrary.org/obo/HP_0003077		
HP:0003076	biolink:PhenotypicFeature	Glycosuria	An increased concentration of glucose in the urine.	UMLS:C0017979|MSH:D006029|SNOMEDCT_US:45154002	hp.json	Glucosuria|Glucose in urine	http://purl.obolibrary.org/obo/HP_0003076		
HP:0040021	biolink:PhenotypicFeature	obsolete Radial deviation of the thumb			hp.json		http://purl.obolibrary.org/obo/HP_0040021		
HP:0003075	biolink:PhenotypicFeature	Hypoproteinemia	A decreased concentration of protein in the blood.	SNOMEDCT_US:8900005|MSH:D007019|UMLS:C0020639	hp.json	Decreased protein levels in blood	http://purl.obolibrary.org/obo/HP_0003075		
HP:0040022	biolink:PhenotypicFeature	Clinodactyly of the 2nd finger		UMLS:C4022486	hp.json	Second finger clinodactyly|Curvature of index finger	http://purl.obolibrary.org/obo/HP_0040022		
HP:0040038	biolink:PhenotypicFeature	obsolete Thin toenail			hp.json		http://purl.obolibrary.org/obo/HP_0040038		
HP:0040039	biolink:PhenotypicFeature	Onycholysis of fingernails		UMLS:C3553044	hp.json	Onycholysis of fingernail|Detachment of fingernails	http://purl.obolibrary.org/obo/HP_0040039		
HP:0040036	biolink:PhenotypicFeature	Onychogryposis of fingernail	Thickened fingernails.	UMLS:C4022477	hp.json	Overgrowth and curving of fingernail	http://purl.obolibrary.org/obo/HP_0040036		
HP:0040037	biolink:PhenotypicFeature	obsolete Thin fingernail (obsolete)			hp.json		http://purl.obolibrary.org/obo/HP_0040037		
GO:0045930	biolink:BiologicalProcess	negative regulation of mitotic cell cycle	Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.		hp.json	down-regulation of progression through mitotic cell cycle|negative regulation of progression through mitotic cell cycle|negative regulation of mitotic cell cycle progression|downregulation of progression through mitotic cell cycle|down regulation of progression through mitotic cell cycle|inhibition of progression through mitotic cell cycle	http://purl.obolibrary.org/obo/GO_0045930		
GO:0045931	biolink:BiologicalProcess	positive regulation of mitotic cell cycle	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.		hp.json	upregulation of progression through mitotic cell cycle|up regulation of progression through mitotic cell cycle|stimulation of progression through mitotic cell cycle|up-regulation of progression through mitotic cell cycle|positive regulation of progression through mitotic cell cycle|positive regulation of mitotic cell cycle progression|activation of progression through mitotic cell cycle	http://purl.obolibrary.org/obo/GO_0045931		
GO:0045938	biolink:BiologicalProcess	positive regulation of circadian sleep/wake cycle, sleep	Any process that activates or increases the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.		hp.json	activation of circadian sleep/wake cycle, sleep|stimulation of circadian sleep/wake cycle, sleep|upregulation of circadian sleep/wake cycle, sleep|positive regulation of sleep|up-regulation of circadian sleep/wake cycle, sleep|up regulation of circadian sleep/wake cycle, sleep	http://purl.obolibrary.org/obo/GO_0045938		
HP:0003049	biolink:PhenotypicFeature	Ulnar deviation of the wrist		SNOMEDCT_US:43689004|UMLS:C0231678	hp.json	Ulnar deviation of wrists	http://purl.obolibrary.org/obo/HP_0003049		
GO:0045939	biolink:BiologicalProcess	negative regulation of steroid metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids.		hp.json	down-regulation of steroid metabolic process|down regulation of steroid metabolic process|negative regulation of steroid metabolism|inhibition of steroid metabolic process|downregulation of steroid metabolic process	http://purl.obolibrary.org/obo/GO_0045939		
HP:0003048	biolink:PhenotypicFeature	Radial head subluxation	Partial dislocation of the head of the radius.	SNOMEDCT_US:417109008|SNOMEDCT_US:95854004|UMLS:C0149977	hp.json	Radial subluxation|Radial-head subluxation	http://purl.obolibrary.org/obo/HP_0003048		
GO:0045936	biolink:BiologicalProcess	negative regulation of phosphate metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.		hp.json	down regulation of phosphate metabolic process|downregulation of phosphate metabolic process|inhibition of phosphate metabolic process|negative regulation of phosphate metabolism|down-regulation of phosphate metabolic process	http://purl.obolibrary.org/obo/GO_0045936		
GO:0045937	biolink:BiologicalProcess	positive regulation of phosphate metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.		hp.json	upregulation of phosphate metabolic process|up-regulation of phosphate metabolic process|up regulation of phosphate metabolic process|activation of phosphate metabolic process|stimulation of phosphate metabolic process|positive regulation of phosphate metabolism	http://purl.obolibrary.org/obo/GO_0045937		
GO:0045934	biolink:BiologicalProcess	negative regulation of nucleobase-containing compound metabolic process	Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.		hp.json	inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	http://purl.obolibrary.org/obo/GO_0045934		
GO:0045935	biolink:BiologicalProcess	positive regulation of nucleobase-containing compound metabolic process	Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.		hp.json	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism|up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	http://purl.obolibrary.org/obo/GO_0045935		
GO:0045932	biolink:BiologicalProcess	negative regulation of muscle contraction	Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.		hp.json	downregulation of muscle contraction|down regulation of muscle contraction|inhibition of muscle contraction|down-regulation of muscle contraction	http://purl.obolibrary.org/obo/GO_0045932		
GO:0045933	biolink:BiologicalProcess	positive regulation of muscle contraction	Any process that activates or increases the frequency, rate or extent of muscle contraction.		hp.json	up regulation of muscle contraction|stimulation of muscle contraction|up-regulation of muscle contraction|activation of muscle contraction|upregulation of muscle contraction	http://purl.obolibrary.org/obo/GO_0045933		
CHEBI:606565	biolink:ChemicalSubstance	N-benzoylglycinate	An alpha-amino-acid anion that is the conjugate base of N-benzoylglycine; major species at pH 7.3.	PMID:22153801|Gmelin:329632|MetaCyc:CPD-425|Reaxys:3610359|Beilstein:3610359	hp.json	N-benzoylglycinate anion|hippurate|2-benzamidoacetate|N-benzoylglycinate(1-)|N-benzoylglycine|(benzoylamino)acetate	http://purl.obolibrary.org/obo/CHEBI_606565		3_STAR
HP:0003041	biolink:PhenotypicFeature	Humeroradial synostosis	An abnormal osseous union (fusion) between the radius and the humerus.	MSH:C535284|UMLS:C1863360|SNOMEDCT_US:205329008|UMLS:C2930865	hp.json	Fusion of upper and lower arm bones|Synostosis of radius and humerus|Humeral-radial synostosis|Radiohumeral synostosis of elbow|Humeral radial synostosis	http://purl.obolibrary.org/obo/HP_0003041		
HP:0040030	biolink:PhenotypicFeature	Chorioretinal hypopigmentation		UMLS:C4022483	hp.json		http://purl.obolibrary.org/obo/HP_0040030		
HP:0003040	biolink:PhenotypicFeature	Arthropathy		UMLS:C0022408|MSH:D007592|SNOMEDCT_US:399269003	hp.json	Disease of the joints	http://purl.obolibrary.org/obo/HP_0003040		
HP:0040031	biolink:PhenotypicFeature	Chorioretinal hyperpigmentation		UMLS:C4022482	hp.json		http://purl.obolibrary.org/obo/HP_0040031		
HP:0003045	biolink:PhenotypicFeature	Abnormal patella morphology	Abnormality of the patella (knee cap).	UMLS:C4021743	hp.json	Abnormal kneecap|Abnormality of the patella|Patellar abnormality	http://purl.obolibrary.org/obo/HP_0003045		hposlim_core
HP:0040034	biolink:PhenotypicFeature	Abnormality of the second metatarsal bone		UMLS:C4022479	hp.json	Abnormality of the 2nd long bone of foot	http://purl.obolibrary.org/obo/HP_0040034		
HP:0040035	biolink:PhenotypicFeature	Abnormality of the fourth metatarsal bone		UMLS:C4022478	hp.json	Abnormality of the 4th long bone of foot	http://purl.obolibrary.org/obo/HP_0040035		
HP:0003044	biolink:PhenotypicFeature	Shoulder flexion contracture	Chronic reduction in active and passive mobility of the shoulder joint due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement.	SNOMEDCT_US:202265005|UMLS:C0409336	hp.json		http://purl.obolibrary.org/obo/HP_0003044		
HP:0040032	biolink:PhenotypicFeature	Hypoplasia of the upper eyelids		UMLS:C4022481	hp.json	Small upper eyelid|Underdevelopment of upper eyelid|Hypotrophic upper eyelid|Short upper eyelid|Decreased size of upper eyelid	http://purl.obolibrary.org/obo/HP_0040032		
HP:0003043	biolink:PhenotypicFeature	Abnormal shoulder morphology	An abnormality of the shoulder, which is defined as the structures surrounding the shoulder joint where the humerus attaches to the scapula.	UMLS:C4025659	hp.json	Abnormality of the shoulder	http://purl.obolibrary.org/obo/HP_0003043		hposlim_core
HP:0040033	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the fifth metatarsal bone		UMLS:C4022480	hp.json	Absent/small 5th long bone of foot|Absent/underdeveloped 5th long bone of foot	http://purl.obolibrary.org/obo/HP_0040033		
HP:0003042	biolink:PhenotypicFeature	Elbow dislocation	Dislocation of the distal humerus out of the elbow joint, where the radius, ulna, and humerus meet.	UMLS:C1403321|UMLS:C1403299|SNOMEDCT_US:125617002|SNOMEDCT_US:417558002|UMLS:C2720437	hp.json	Ulnohumeral dislocation|Elbow dislocations|Radiohumeral dislocation|Dislocations of the elbows|Elbow dislocation|Radiocapitellar dislocation	http://purl.obolibrary.org/obo/HP_0003042		
HP:0040049	biolink:PhenotypicFeature	Macular edema	Thickening of the retina that takes place due to accumulation of fluid in the macula as a nonspecific response to blood-retinal barrier breakdown. Macular edema is a common pathological response to a wide variety of ocular insults, most commonly after intraocular (e.g. cataract) surgery or in association with retinal vascular (e.g. diabetic eye disease, retinal vein occlusion) or inflammatory (e.g. uveitis) disease.	MSH:D008269|UMLS:C0271051|SNOMEDCT_US:37231002	hp.json	Macular oedema	http://purl.obolibrary.org/obo/HP_0040049		
HP:0040047	biolink:PhenotypicFeature	Abnormal right hemidiaphragm morphology		UMLS:C4022470	hp.json	Abnormality of the right hemidiaphragm	http://purl.obolibrary.org/obo/HP_0040047		
HP:0040048	biolink:PhenotypicFeature	obsolete Aplasia of the left hemidiaphragm			hp.json		http://purl.obolibrary.org/obo/HP_0040048		
CHEBI:606564	biolink:ChemicalSubstance	prostaglandin E2(1-)	The conjugate base of prostaglandin E2; major species at pH 7.3.	MetaCyc:5Z13E-15S-1115-DIHYDROXY-9-OXOPROS|Beilstein:8364130	hp.json	(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oate|prostaglandin E2 anion|prostaglandin E2	http://purl.obolibrary.org/obo/CHEBI_606564		3_STAR
GO:0045940	biolink:BiologicalProcess	positive regulation of steroid metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving steroids.		hp.json	up-regulation of steroid metabolic process|positive regulation of steroid metabolism|up regulation of steroid metabolic process|activation of steroid metabolic process|stimulation of steroid metabolic process|upregulation of steroid metabolic process	http://purl.obolibrary.org/obo/GO_0045940		
PR:000007636	biolink:Protein	forkhead box protein N1	A protein that is a translation product of the human FOXN1 gene or a 1:1 ortholog thereof.	IUPHARobj:2958	hp.json	Hfh11|HFH-11|HNF-3/forkhead homolog 11|hepatocyte nuclear factor 3 forkhead homolog 11|RONU|winged-helix transcription factor nude|FOXN1|WHN|Fkh19	http://purl.obolibrary.org/obo/PR_000007636		
HP:0003059	biolink:PhenotypicFeature	Abnormality of the radioulnar joints		UMLS:C4025658	hp.json		http://purl.obolibrary.org/obo/HP_0003059		
GO:0045947	biolink:BiologicalProcess	negative regulation of translational initiation	Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.		hp.json	down regulation of translational initiation|inhibition of translational initiation|down-regulation of translational initiation|downregulation of translational initiation	http://purl.obolibrary.org/obo/GO_0045947		
GO:0045948	biolink:BiologicalProcess	positive regulation of translational initiation	Any process that activates or increases the frequency, rate or extent of translational initiation.		hp.json	upregulation of translational initiation|up regulation of translational initiation|stimulation of translational initiation|up-regulation of translational initiation|activation of translational initiation	http://purl.obolibrary.org/obo/GO_0045948		
HP:0003057	biolink:PhenotypicFeature	Tetraamelia	Amelia of all four limbs.	SNOMEDCT_US:702313004|UMLS:C2931216|MSH:C536498	hp.json	Tetra-amelia	http://purl.obolibrary.org/obo/HP_0003057		
GO:0031399	biolink:BiologicalProcess	regulation of protein modification process	Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.		hp.json		http://purl.obolibrary.org/obo/GO_0031399		goslim_yeast
HP:0040042	biolink:PhenotypicFeature	Aplasia of the eccrine sweat glands		UMLS:C4022475	hp.json	Absent eccrine sweat glands	http://purl.obolibrary.org/obo/HP_0040042		
HP:0003051	biolink:PhenotypicFeature	Enlarged metaphyses	Abnormal increase in size of one or more metaphyses.	UMLS:C1855544	hp.json	Enlarged wide portion of a long bone	http://purl.obolibrary.org/obo/HP_0003051		
HP:0040040	biolink:PhenotypicFeature	Toenail onycholysis	Painless and spontaneous separation of a toenail from the nail bed.	UMLS:C4022476	hp.json	Detachment of toenails|Onycholysis of toenails	http://purl.obolibrary.org/obo/HP_0040040		
HP:0040045	biolink:PhenotypicFeature	Abnormal hemidiaphragm morphology		UMLS:C4022472	hp.json	Abnormality of the hemidiaphragms	http://purl.obolibrary.org/obo/HP_0040045		
HP:0040046	biolink:PhenotypicFeature	Abnormal left hemidiaphragm morphology		UMLS:C4022471	hp.json	Abnormality of the left hemidiaphragm	http://purl.obolibrary.org/obo/HP_0040046		
HP:0040043	biolink:PhenotypicFeature	Hypoplasia of the eccrine sweat glands		UMLS:C4022474	hp.json	Underdeveloped major sweat glands	http://purl.obolibrary.org/obo/HP_0040043		
HP:0040044	biolink:PhenotypicFeature	Hypoplasia of the diaphragm		UMLS:C4022473	hp.json	Underdeveloped diaphragm	http://purl.obolibrary.org/obo/HP_0040044		
HP:0003053	biolink:PhenotypicFeature	Epiphyseal deformities of tubular bones		UMLS:C1854786	hp.json		http://purl.obolibrary.org/obo/HP_0003053		
HP:0030650	biolink:PhenotypicFeature	Focal		SNOMEDCT_US:87017008|UMLS:C0205234	hp.json		http://purl.obolibrary.org/obo/HP_0030650		
HP:0030651	biolink:PhenotypicFeature	Multifocal		UMLS:C0205292|SNOMEDCT_US:524008	hp.json		http://purl.obolibrary.org/obo/HP_0030651		
HP:0030652	biolink:PhenotypicFeature	Vitreous haze	Vitreous haze is the obscuration of fundus details by vitreous cells and protein exudation.	UMLS:C4073113	hp.json		http://purl.obolibrary.org/obo/HP_0030652		
HP:0030657	biolink:PhenotypicFeature	Umbilical cord hematoma	Bleeding from the vessels of the cord with extravasation of blood into the Wharton jelly surrounding the umbilical cord vessels.	SNOMEDCT_US:86256001|UMLS:C0269855	hp.json	Umbilical cord haematoma	http://purl.obolibrary.org/obo/HP_0030657		
HP:0030658	biolink:PhenotypicFeature	Marginal umbilical cord insertion	Insertion of the umbilical cord within 2 cm from the placental edge.	UMLS:C0266788|SNOMEDCT_US:51519001	hp.json	Marginal cord insertion|Battledore placenta	http://purl.obolibrary.org/obo/HP_0030658		
HP:0030659	biolink:PhenotypicFeature	Velamentous cord insertion	Insertion of the umbilical cord into the chorio-amniotic membranes of the placenta.	UMLS:C0266789|SNOMEDCT_US:77278008	hp.json		http://purl.obolibrary.org/obo/HP_0030659		
HP:0030654	biolink:PhenotypicFeature	Umbilical cord cyst	Any cystic lesion associated with the umbilical cord.	UMLS:C4073114	hp.json		http://purl.obolibrary.org/obo/HP_0030654		
HP:0030655	biolink:PhenotypicFeature	Umbilical cord knot	An entwining of a segment of umbilical cord, usually without obstructing fetal circulation and commonly result from fetal slippage through a loop of the cord.	SNOMEDCT_US:237309005|UMLS:C0344363	hp.json		http://purl.obolibrary.org/obo/HP_0030655		
HP:0030656	biolink:PhenotypicFeature	Umbilical vein varix	Focal dilation of the umbilical vein.	UMLS:C4073115	hp.json		http://purl.obolibrary.org/obo/HP_0030656		
HP:0030660	biolink:PhenotypicFeature	Furcate cord insertion	Branching of the umbilical cord before its insertion into the placenta.	UMLS:C4073116	hp.json		http://purl.obolibrary.org/obo/HP_0030660		
GO:0045963	biolink:BiologicalProcess	negative regulation of dopamine metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.		hp.json	downregulation of dopamine metabolic process|down regulation of dopamine metabolic process|inhibition of dopamine metabolic process|down-regulation of dopamine metabolic process|negative regulation of dopamine metabolism	http://purl.obolibrary.org/obo/GO_0045963		
HP:0030661	biolink:PhenotypicFeature	Vitreous snowballs	Yellow-white inflammatory aggregates in the vitreous that are found in the midvitreous and inferior periphery.	SNOMEDCT_US:417393008|UMLS:C1563272	hp.json		http://purl.obolibrary.org/obo/HP_0030661		
GO:0045964	biolink:BiologicalProcess	positive regulation of dopamine metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving dopamine.		hp.json	up regulation of dopamine metabolic process|stimulation of dopamine metabolic process|activation of dopamine metabolic process|up-regulation of dopamine metabolic process|upregulation of dopamine metabolic process|positive regulation of dopamine metabolism	http://purl.obolibrary.org/obo/GO_0045964		
HP:0030662	biolink:PhenotypicFeature	Vitreous inflammatory cells	The presence of inflammatory cells such as lymphocytes and macrophages in the vitreous.	UMLS:C4073117	hp.json		http://purl.obolibrary.org/obo/HP_0030662		
HP:0030663	biolink:PhenotypicFeature	Optically empty vitreous	Vestigial vitreous gel occupying the immediate retrolental space and minimal to no discernable gel in the central vitreous cavity, giving the appearance of an empty vitreous cavity.	UMLS:C4073118	hp.json		http://purl.obolibrary.org/obo/HP_0030663		
HP:0030668	biolink:PhenotypicFeature	Periorbital dermoid cyst	A cyst that is localized in the region of the orbit and exhibits an epithelial lining with a keratin-filled lumen. Hair follicles are one of the adnexal structures that are commonly found in walls of dermoid cysts.	UMLS:C4073119	hp.json		http://purl.obolibrary.org/obo/HP_0030668		
HP:0030669	biolink:PhenotypicFeature	Abnormal ocular adnexa morphology	A structural anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.	UMLS:C4073120	hp.json		http://purl.obolibrary.org/obo/HP_0030669		
HP:0030664	biolink:PhenotypicFeature	Beevor's sign	Weakness of the inferior portion of the rectus abdominal muscle, which is ascertained clinically as follows. When a patient sits up or raises the head from a recumbent position, the umbilicus is displaced toward the head. This is the result of paralysis of the inferior portion of the rectus abdominal muscle, so that the upper fibres predominate pulling upwards the umbilicus.	SNOMEDCT_US:61282003|UMLS:C0231616	hp.json		http://purl.obolibrary.org/obo/HP_0030664		
HP:0030665	biolink:PhenotypicFeature	Rubral tremor	Rubral tremor is characterized by a slow coarse tremor at rest that is exacerbated by postural adjustments and by guided voluntary movements.	UMLS:C0750940|MSH:D001259	hp.json	Holmes' tremor	http://purl.obolibrary.org/obo/HP_0030665		
HP:0030666	biolink:PhenotypicFeature	Retinal neovascularization	In wound repair, neovascularization (NV) involves the sprouting of new vessels from pre-existent vessels to repair or replace damaged vessels. In the retina, NV is a response to ischemia. The NV adheres to the inner surface of the retina and outer surface of the vitreous. NV are deficient in tight junctions and hence leak plasma into surrounding tissue including the vitreous. Plasma causes the vitreous gel to degenerate, contract, and eventually collapse which pulls on the retina. Since retinal NV is adherent to both retina and vitreous, as the vitreous contracts the NV may be sheared resulting in vitreous hemorrhage or the NV may remain intact and pull the retina with the vitreous resulting in retinal elevation referred to as traction retinal detachment.	MSH:D015861|UMLS:C0035320|SNOMEDCT_US:61267008	hp.json	Retinal neovascularisation	http://purl.obolibrary.org/obo/HP_0030666		
HP:0030667	biolink:PhenotypicFeature	Peripheral retinal neovascularization	A type of retinal neovascularization that affects the periphery of the retina.	SNOMEDCT_US:247100001|UMLS:C0474355	hp.json		http://purl.obolibrary.org/obo/HP_0030667		
HP:0003091	biolink:PhenotypicFeature	Trophic limb changes	Trophic changes occurring in a limb.	UMLS:C4025657	hp.json		http://purl.obolibrary.org/obo/HP_0003091		
HP:0003090	biolink:PhenotypicFeature	Hypoplasia of the capital femoral epiphysis	Underdevelopment of the proximal epiphysis of the femur.	UMLS:C1839254	hp.json	Underdevelopment of the innermost thighbone end part|Small femoral capital epiphyses|Small capital femoral epiphyses|Small innermost thighbone end part|Small proximal femoral epiphyses	http://purl.obolibrary.org/obo/HP_0003090		
HP:0030671	biolink:PhenotypicFeature	Abnormal common tendinous ring morphology	Any anomaly of the ring of fibrous tissue that surrounds the optic nerve at its entrance at the apex of the orbit. The common tendinous ring, also known as the annulus of Zinn or annular tendon, is the origin for five of the seven extraocular muscles.	UMLS:C4073122	hp.json	Abnormality of the common tendinous ring	http://purl.obolibrary.org/obo/HP_0030671		
HP:0030672	biolink:PhenotypicFeature	Asteroid hyalosis	The presence of small, white vitreous opacities consisting of calcium phosphate and complex, layered lipid deposits.	SNOMEDCT_US:95800001|UMLS:C0521770	hp.json		http://purl.obolibrary.org/obo/HP_0030672		
HP:0030673	biolink:PhenotypicFeature	Erosive vitreoretinopathy	A form of vitreoretinopathy characterized by thinning (erosion) of the retinal pigment epithelium that permits increased visualization of the choroidal vessels.	SNOMEDCT_US:232064001|UMLS:C1840452|MSH:C536075	hp.json		http://purl.obolibrary.org/obo/HP_0030673		
HP:0030674	biolink:PhenotypicFeature	Antenatal onset	Onset prior to birth.	UMLS:C2673646	hp.json	Prenatal onset|Intrauterine onset|Onset in utero	http://purl.obolibrary.org/obo/HP_0030674		
HP:0030670	biolink:PhenotypicFeature	Hamartoma of the orbital region	A hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the orbital region.	UMLS:C4073121	hp.json		http://purl.obolibrary.org/obo/HP_0030670		
HP:0030679	biolink:PhenotypicFeature	Ash-leaf spot	A hypopigmented spot in the shape of a leaf from the mountain ash tree.	UMLS:C4073125	hp.json		http://purl.obolibrary.org/obo/HP_0030679		
HP:0030675	biolink:PhenotypicFeature	Contracture of proximal interphalangeal joints of 2nd-5th fingers	Chronic loss of joint motion of the proximal interphalangeal joint of the 2nd, 3rd, 4th, and 5th fingers due to structural changes in non-bony tissue.	UMLS:C4073123	hp.json		http://purl.obolibrary.org/obo/HP_0030675		
HP:0030676	biolink:PhenotypicFeature	Satyr ear	Sharp pointed superior portion of the ear, with variable overfolding of the helix.	UMLS:C4048833	hp.json	Devil ear	http://purl.obolibrary.org/obo/HP_0030676		
HP:0030677	biolink:PhenotypicFeature	Mozart ear	A congenital auricular deformity, which is mainly characterized by a bulging appearance of the anterosuperior portion of the auricle, a convexly protruded cavum conchae, and a slit-like narrowing of the orifice of the external auditory meatus.	UMLS:C4073124	hp.json		http://purl.obolibrary.org/obo/HP_0030677		
HP:0003085	biolink:PhenotypicFeature	Long fibula	Disproportionately long fibulae.	UMLS:C1848109	hp.json	Disproportionately long fibula|Long fibula|Long calf bone	http://purl.obolibrary.org/obo/HP_0003085		hposlim_core
HP:0003084	biolink:PhenotypicFeature	Fractures of the long bones	An increased tendency to fractures of the long bones (Mainly, the femur, tibia, fibula, humerus, radius, and ulna).	UMLS:C0240231	hp.json	Increased long bone fracture rate	http://purl.obolibrary.org/obo/HP_0003084		
HP:0003083	biolink:PhenotypicFeature	Dislocated radial head	A dislocation of the head of the radius from its socket in the elbow joint.	SNOMEDCT_US:9634000|UMLS:C0265563	hp.json	Dislocated radius|Radial head dislocation/subluxation|Dislocated radial heads|Congenital radial head dislocation|Dislocation of the radial head|Dislocation of radial head|Radial head dislocation|Radial dislocation	http://purl.obolibrary.org/obo/HP_0003083		
HP:0003089	biolink:PhenotypicFeature	Hamstring contractures		SNOMEDCT_US:203074005|UMLS:C0410266	hp.json	Hamstring contractures	http://purl.obolibrary.org/obo/HP_0003089		
HP:0003088	biolink:PhenotypicFeature	Premature osteoarthritis		UMLS:C1835121	hp.json	Premature arthritis|Premature osteoarthritis	http://purl.obolibrary.org/obo/HP_0003088		
HP:0003086	biolink:PhenotypicFeature	Acromesomelia	Small hands and feet.	UMLS:C1864365	hp.json		http://purl.obolibrary.org/obo/HP_0003086		
HP:0040006	biolink:PhenotypicFeature	Mortality/Aging		UMLS:C4022499	hp.json		http://purl.obolibrary.org/obo/HP_0040006		
HP:0040004	biolink:PhenotypicFeature	Abnormality of corneal shape		UMLS:C4022500	hp.json		http://purl.obolibrary.org/obo/HP_0040004		
HP:0040009	biolink:PhenotypicFeature	Hyperparakeratosis	Abnormal keratinization of the epidermal stratum coreum (horny layer) with increased keratin formation, preservation of the nuclei in the superficial cells, and absence of the stratum granulosum.	SNOMEDCT_US:125554003|UMLS:C1265968	hp.json		http://purl.obolibrary.org/obo/HP_0040009		
HP:0040007	biolink:PhenotypicFeature	Absent pigmentation of chest	Lack of skin pigmentation (coloring) of the chest.	UMLS:C4022498	hp.json	Lack of skin coloring on chest|Lack of skin colouring on chest	http://purl.obolibrary.org/obo/HP_0040007		
HP:0040008	biolink:PhenotypicFeature	Aplasia of facial bones		UMLS:C4022497|UMLS:C1385254|UMLS:C4280301|UMLS:C4280300	hp.json	Missing facial bones|Failure of development of facial skeleton|Aplasia of facial skeleton|Absence of facial bones|Agenesis of facial bones|Failure of development of facial bones	http://purl.obolibrary.org/obo/HP_0040008		
GO:0045985	biolink:BiologicalProcess	positive regulation of pyrimidine nucleobase metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.		hp.json	up-regulation of pyrimidine base metabolic process|up regulation of pyrimidine base metabolic process|activation of pyrimidine base metabolic process|positive regulation of pyrimidine base metabolic process|stimulation of pyrimidine base metabolic process|upregulation of pyrimidine base metabolic process|positive regulation of pyrimidine base metabolism	http://purl.obolibrary.org/obo/GO_0045985		
HP:0030682	biolink:PhenotypicFeature	Left ventricular noncompaction	Left ventricular noncompaction (LVNC) is defined by 3 markers: prominent left ventricular (LV) trabeculae, deep intertrabecular recesses, and the thin compacted layer.	UMLS:C1960469	hp.json		http://purl.obolibrary.org/obo/HP_0030682		
HP:0030683	biolink:PhenotypicFeature	Vaginitis	Inflammation of the vagina that can result from a spectrum of conditions that cause vaginal and sometimes vulvar symptoms, such as itching, burning, irritation, odor, and vaginal discharge.	SNOMEDCT_US:30800001|MSH:D014627|UMLS:C0042267	hp.json	Vulvovaginitis	http://purl.obolibrary.org/obo/HP_0030683		
GO:0045986	biolink:BiologicalProcess	negative regulation of smooth muscle contraction	Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.		hp.json	down regulation of smooth muscle contraction|inhibition of smooth muscle contraction|downregulation of smooth muscle contraction|smooth muscle relaxation|down-regulation of smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0045986		
GO:0045983	biolink:BiologicalProcess	positive regulation of purine nucleobase metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving purine bases.		hp.json	positive regulation of purine base metabolic process|activation of purine base metabolic process|positive regulation of purine base metabolism|stimulation of purine base metabolic process|upregulation of purine base metabolic process|up-regulation of purine base metabolic process|up regulation of purine base metabolic process	http://purl.obolibrary.org/obo/GO_0045983		
HP:0030684	biolink:PhenotypicFeature	Abnormal adiponectin level	A deviation from the normal circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue, and that plays a crucial role in the regulation of insulin sensitivity and glucose metabolism.	UMLS:C4073126	hp.json		http://purl.obolibrary.org/obo/HP_0030684		
GO:0045984	biolink:BiologicalProcess	negative regulation of pyrimidine nucleobase metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases.		hp.json	inhibition of pyrimidine base metabolic process|downregulation of pyrimidine base metabolic process|negative regulation of pyrimidine base metabolism|down-regulation of pyrimidine base metabolic process|down regulation of pyrimidine base metabolic process|negative regulation of pyrimidine base metabolic process	http://purl.obolibrary.org/obo/GO_0045984		
HP:0030685	biolink:PhenotypicFeature	Decreased adiponectin level	A reduced circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue.	UMLS:C4073127	hp.json		http://purl.obolibrary.org/obo/HP_0030685		
GO:0045981	biolink:BiologicalProcess	positive regulation of nucleotide metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.		hp.json	upregulation of nucleotide metabolic process|positive regulation of nucleotide metabolism|up regulation of nucleotide metabolic process|stimulation of nucleotide metabolic process|up-regulation of nucleotide metabolic process|activation of nucleotide metabolic process	http://purl.obolibrary.org/obo/GO_0045981		
GO:0045982	biolink:BiologicalProcess	negative regulation of purine nucleobase metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases.		hp.json	down-regulation of purine base metabolic process|negative regulation of purine base metabolic process|down regulation of purine base metabolic process|inhibition of purine base metabolic process|downregulation of purine base metabolic process|negative regulation of purine base metabolism	http://purl.obolibrary.org/obo/GO_0045982		
HP:0030680	biolink:PhenotypicFeature	Abnormality of cardiovascular system morphology	Any structural anomaly of the heart and great vessels.	UMLS:C4049796	hp.json	Cardiovascular malformations	http://purl.obolibrary.org/obo/HP_0030680		
GO:0045980	biolink:BiologicalProcess	negative regulation of nucleotide metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.		hp.json	down regulation of nucleotide metabolic process|inhibition of nucleotide metabolic process|down-regulation of nucleotide metabolic process|negative regulation of nucleotide metabolism|downregulation of nucleotide metabolic process	http://purl.obolibrary.org/obo/GO_0045980		
HP:0030681	biolink:PhenotypicFeature	Abnormal morphology of myocardial trabeculae	Any structural anomaly of the muscular columns which project from the inner surface of the right and left ventricles of the heart (cardiac trabeculae, trabeculae carneae).	UMLS:C4073289	hp.json		http://purl.obolibrary.org/obo/HP_0030681		
GO:0070925	biolink:BiologicalProcess	organelle assembly	The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0070925		goslim_yeast
HP:0030686	biolink:PhenotypicFeature	Increased adiponectin level	An elevated circulating concentration of adiponectin, a 30-kDa complement C1-related protein that is the most abundant secreted protein expressed in adipose tissue.	UMLS:C4073128	hp.json		http://purl.obolibrary.org/obo/HP_0030686		
GO:0045989	biolink:BiologicalProcess	positive regulation of striated muscle contraction	Any process that activates or increases the frequency, rate or extent of striated muscle contraction.		hp.json	up-regulation of striated muscle contraction|up regulation of striated muscle contraction|activation of striated muscle contraction|stimulation of striated muscle contraction|upregulation of striated muscle contraction	http://purl.obolibrary.org/obo/GO_0045989		
HP:0030687	biolink:PhenotypicFeature	Abnormal glucagon level	A deviation from the normal concentration of glucagon in the blood circulation.	UMLS:C4073129	hp.json		http://purl.obolibrary.org/obo/HP_0030687		
HP:0030688	biolink:PhenotypicFeature	Increased glucagon level	An elevated concentration of glucagon in the blood circulation.	SNOMEDCT_US:131106002|UMLS:C1295677	hp.json		http://purl.obolibrary.org/obo/HP_0030688		
GO:0045987	biolink:BiologicalProcess	positive regulation of smooth muscle contraction	Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.		hp.json	up-regulation of smooth muscle contraction|up regulation of smooth muscle contraction|activation of smooth muscle contraction|stimulation of smooth muscle contraction|upregulation of smooth muscle contraction	http://purl.obolibrary.org/obo/GO_0045987		
GO:0045988	biolink:BiologicalProcess	negative regulation of striated muscle contraction	Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.		hp.json	inhibition of striated muscle contraction|downregulation of striated muscle contraction|down-regulation of striated muscle contraction|down regulation of striated muscle contraction	http://purl.obolibrary.org/obo/GO_0045988		
HP:0030689	biolink:PhenotypicFeature	Decreased glucagon level	A reduced concentration of glucagon in the blood circulation.	SNOMEDCT_US:131107006|UMLS:C1295678	hp.json		http://purl.obolibrary.org/obo/HP_0030689		
HP:0003095	biolink:PhenotypicFeature	Septic arthritis		SNOMEDCT_US:396234004|UMLS:C4280547|MSH:D001170|UMLS:C0003869|SNOMEDCT_US:372939007	hp.json	Infected joint	http://purl.obolibrary.org/obo/HP_0003095		
HP:0003093	biolink:PhenotypicFeature	Limited hip extension	Limitation of the extension of the hip, i.e., decreased ability to straighten the hip joint and thereby increase the angle between torso and thigh; moving the thigh or top of the pelvis backward.	UMLS:C3553368	hp.json	Restricted hip extension|Limited hip extension	http://purl.obolibrary.org/obo/HP_0003093		
HP:0003099	biolink:PhenotypicFeature	Fibular overgrowth	Relatively increased growth of the fibula compared to that of the tibia.	UMLS:C1864298	hp.json	Overgrowth of calf bone	http://purl.obolibrary.org/obo/HP_0003099		
HP:0003097	biolink:PhenotypicFeature	Short femur	An abnormal shortening of the femur.	SNOMEDCT_US:93255008|UMLS:C0345375	hp.json	Hypoplasia of the femora|Short femurs|Femoral hypoplasia|Short thighbone	http://purl.obolibrary.org/obo/HP_0003097		hposlim_core
CHEBI:22744	biolink:ChemicalSubstance	benzyl group			hp.json	Bn|phenylalanine side-chain|phenylmethyl|benzyl|C6H5-CH2-	http://purl.obolibrary.org/obo/CHEBI_22744		3_STAR
HP:0030613	biolink:PhenotypicFeature	Abnormal foveal morphology on macular OCT		UMLS:C4073083	hp.json		http://purl.obolibrary.org/obo/HP_0030613		
HP:0030614	biolink:PhenotypicFeature	Foveal photoreceptor layer loss on macular OCT		UMLS:C4073084	hp.json		http://purl.obolibrary.org/obo/HP_0030614		
UBERON:0005594	biolink:AnatomicalEntity	head somite	Somite located in the head region, caudal to the otic vesicle.	XAO:0000313|EHDAA2:0003437|EMAPA:16172	hp.json	occipital somite|cranial somite|occipital somite	http://purl.obolibrary.org/obo/UBERON_0005594		
HP:0005648	biolink:PhenotypicFeature	Bilateral ulnar hypoplasia	Underdevelopment of the ulna on both sides.	UMLS:C4025166	hp.json		http://purl.obolibrary.org/obo/HP_0005648		
HP:0030615	biolink:PhenotypicFeature	Foveal photoreceptor outer segment loss on macular OCT		UMLS:C4073085	hp.json		http://purl.obolibrary.org/obo/HP_0030615		
HP:0030616	biolink:PhenotypicFeature	Foveal retinal pigment epithelial loss on macular OCT		UMLS:C4073086	hp.json		http://purl.obolibrary.org/obo/HP_0030616		
HP:0005643	biolink:PhenotypicFeature	Short 3rd toe	Underdevelopment (hypoplasia) of the third toe.	UMLS:C4021628	hp.json	Brachydactyly of third toes|Short third toe|Short 3rd toe	http://purl.obolibrary.org/obo/HP_0005643		
HP:0030610	biolink:PhenotypicFeature	Photoreceptor outer segment loss on macular OCT		UMLS:C4073080	hp.json		http://purl.obolibrary.org/obo/HP_0030610		
HGNC:4191	biolink:Gene	GCG (human)	A protein coding gene GCG in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4191		
HP:0030611	biolink:PhenotypicFeature	Retinal pigment epithelial loss on macular OCT		UMLS:C4073081	hp.json		http://purl.obolibrary.org/obo/HP_0030611		
HP:0005645	biolink:PhenotypicFeature	Intervertebral disk calcification	The presence of abnormal calcium deposition of the intervertebral disk.	SNOMEDCT_US:240211000|UMLS:C0410607	hp.json	Multiple intervertebral disk calcifications|Intervertebral disc calcification|Multiple intervertebral disc calcifications	http://purl.obolibrary.org/obo/HP_0005645		hposlim_core
HP:0030612	biolink:PhenotypicFeature	Abnormal retinal morphology on macular OCT		UMLS:C4073082	hp.json		http://purl.obolibrary.org/obo/HP_0030612		
HP:0005640	biolink:PhenotypicFeature	Abnormal vertebral segmentation and fusion		UMLS:C4025167	hp.json		http://purl.obolibrary.org/obo/HP_0005640		
HP:0030617	biolink:PhenotypicFeature	Abnormal OCT-measured foveal thickness		UMLS:C4073087	hp.json		http://purl.obolibrary.org/obo/HP_0030617		
HP:0030618	biolink:PhenotypicFeature	Increased OCT-measured foveal thickness		UMLS:C4073088	hp.json		http://purl.obolibrary.org/obo/HP_0030618		
UBERON:0005598	biolink:AnatomicalEntity	trunk somite	A somite that is part of a trunk.	XAO:0000314|EHDAA2:0003438|EMAPA:16184|AAO:0010385	hp.json		http://purl.obolibrary.org/obo/UBERON_0005598		
HP:0030619	biolink:PhenotypicFeature	Reduced OCT-measured foveal thickness		UMLS:C4073089	hp.json		http://purl.obolibrary.org/obo/HP_0030619		
UBERON:0005597	biolink:AnatomicalEntity	lung primordium	A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum.	EMAPA:36007|XAO:0001002|AAO:0011059|EFO:0002578	hp.json	lung diverticulum|lung endoderm|lateral diverticula	http://purl.obolibrary.org/obo/UBERON_0005597		efo_slim
CHEBI:46701	biolink:ChemicalSubstance	pyrrolidinemonocarboxylic acid			hp.json	pyrrolidinemonocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_46701		3_STAR
HP:0030624	biolink:PhenotypicFeature	Subretinal hyporeflective spaces on macular OCT		UMLS:C4073094	hp.json		http://purl.obolibrary.org/obo/HP_0030624		
HP:0030625	biolink:PhenotypicFeature	Hyporeflective spaces on macular OCT		UMLS:C4073095	hp.json		http://purl.obolibrary.org/obo/HP_0030625		
HP:0005659	biolink:PhenotypicFeature	Thoracic kyphoscoliosis		UMLS:C4015465	hp.json		http://purl.obolibrary.org/obo/HP_0005659		
HP:0030626	biolink:PhenotypicFeature	Foveal intraretinal hyporeflective spaces on macular OCT		UMLS:C4073096	hp.json		http://purl.obolibrary.org/obo/HP_0030626		
HP:0030627	biolink:PhenotypicFeature	Foveal hyporeflective spaces on macular OCT		UMLS:C4073097	hp.json		http://purl.obolibrary.org/obo/HP_0030627		
HP:0005653	biolink:PhenotypicFeature	Moderate generalized osteoporosis	Moderate osteoporosis.	UMLS:C4025163	hp.json	Moderate generalised osteoporosis	http://purl.obolibrary.org/obo/HP_0005653		
HP:0030620	biolink:PhenotypicFeature	Inner retinal layer loss on macular OCT		UMLS:C4073090	hp.json		http://purl.obolibrary.org/obo/HP_0030620		
HP:0030621	biolink:PhenotypicFeature	Foveal inner retinal layer loss on macular OCT		UMLS:C4073091	hp.json		http://purl.obolibrary.org/obo/HP_0030621		
HP:0005655	biolink:PhenotypicFeature	Multiple digital exostoses	Multiple exostoses originating in the fingers and toes.	UMLS:C4025162	hp.json		http://purl.obolibrary.org/obo/HP_0005655		
HP:0030622	biolink:PhenotypicFeature	Abnormal foveal pit on macular OCT		UMLS:C4073092	hp.json		http://purl.obolibrary.org/obo/HP_0030622		
HP:0005656	biolink:PhenotypicFeature	Positional foot deformity	A foot deformity resulting due to an abnormality affecting the muscle and soft tissue. In contrast if the bones of the foot are affected the term structural foot deformity applies.	UMLS:C4025161	hp.json		http://purl.obolibrary.org/obo/HP_0005656		
HP:0030623	biolink:PhenotypicFeature	Intraretinal hyporeflective spaces on macular OCT		UMLS:C4073093	hp.json		http://purl.obolibrary.org/obo/HP_0030623		
HP:0005650	biolink:PhenotypicFeature	2-5 finger cutaneous syndactyly	A soft tissue continuity in the anteroposterior axis between the second to the fifth fingers that extends distally to at least the level of the proximal interphalangeal joints.	UMLS:C4025165	hp.json	Cutaneous syndactyly between fingers 2 and 5	http://purl.obolibrary.org/obo/HP_0005650		
HP:0005652	biolink:PhenotypicFeature	Cortical sclerosis	Sclerosis (abnormal hardening) of cortical bone, characterized by increased radiodensity.	UMLS:C4025164	hp.json		http://purl.obolibrary.org/obo/HP_0005652		
HP:0030628	biolink:PhenotypicFeature	Foveal subretinal hyporeflective spaces on macular OCT		UMLS:C4073098	hp.json		http://purl.obolibrary.org/obo/HP_0030628		
HP:0030629	biolink:PhenotypicFeature	Perifoveal ring of hyperautofluorescence		UMLS:C4073099	hp.json		http://purl.obolibrary.org/obo/HP_0030629		
HP:0030630	biolink:PhenotypicFeature	Irregular central macular autofluorescence		UMLS:C4073100	hp.json		http://purl.obolibrary.org/obo/HP_0030630		
HGNC:4164	biolink:Gene	GAST (human)	A protein coding gene GAST in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4164		
HP:0030635	biolink:PhenotypicFeature	Retinal dystrophy with early macular involvement		UMLS:C4049066	hp.json		http://purl.obolibrary.org/obo/HP_0030635		
HP:0005625	biolink:PhenotypicFeature	Osteoporosis of vertebrae	Osteoporosis affecting predominantly the vertebrae.	UMLS:C4025170	hp.json		http://purl.obolibrary.org/obo/HP_0005625		
HP:0030636	biolink:PhenotypicFeature	Occult macular dystrophy	Occult macular dystrophy is a, typically hereditary, abnormality of the macula associated with progressive foveal cone dysfunction and no apparent fundoscopic, full-field electroretinogram (ERG), or fluorescein angiogram abnormalities.		hp.json		http://purl.obolibrary.org/obo/HP_0030636		
HP:0030637	biolink:PhenotypicFeature	Congenital stationary cone dysfunction	Retinal phenotype characterised by cone photoreceptor dysfunction and preserved rod system. The abnormality is typically stationary or very slowly progressive and findings may include reduced central vision, colour vision abnormalities, nystagmus and photophobia.	UMLS:C0543968	hp.json	Cone dysfunction syndrome|Cone dysfunction	http://purl.obolibrary.org/obo/HP_0030637		
HP:0005626	biolink:PhenotypicFeature	Posterior fusion of lumbosacral vertebrae	Bony fusion of the posterior part of the L5 vertebral body with the sacrum.	UMLS:C4025169	hp.json		http://purl.obolibrary.org/obo/HP_0005626		
HP:0030638	biolink:PhenotypicFeature	Congenital stationary night blindness with normal fundus		UMLS:C4073105	hp.json		http://purl.obolibrary.org/obo/HP_0030638		
HP:0005627	biolink:PhenotypicFeature	Type D brachydactyly	This type of brachydactyly is characterized by short and broad terminal phalanges of the thumbs and big toes.	MSH:C562420|UMLS:C0220664	hp.json	Brachydactyly type D	http://purl.obolibrary.org/obo/HP_0005627		
HP:0005620	biolink:PhenotypicFeature	Hypermobility of interphalangeal joints	The ability of the interphalangeal joints to move beyond their normal range of motion.	UMLS:C4025172	hp.json	Increased mobility of hinge joints	http://purl.obolibrary.org/obo/HP_0005620		
HP:0030631	biolink:PhenotypicFeature	Hyperautofluorescent macular lesion	Increased amount of autofluorescence in the macula as ascertained by fundus autofluorescence imaging.	UMLS:C4073101	hp.json		http://purl.obolibrary.org/obo/HP_0030631		
HP:0030632	biolink:PhenotypicFeature	Hypoautofluorescent macular lesion	Decreased amount of autofluorescence in the macula as ascertained by fundus autofluorescence imaging.	UMLS:C4073102	hp.json	Hypo-autofluorescent macular lesion	http://purl.obolibrary.org/obo/HP_0030632		
HP:0005621	biolink:PhenotypicFeature	Trapezoidal vertebral body	An anomalous trapezoidal appearance of a vertebral body. A trapezoid is a four-sided shape that has two sides that are parallel and two sides that are not parallel. In this case, the two lateral sides of the vertebra are parallel, and the top and the bottom are slanted with respect to each other such that the vertebra is shorter in the fron or back than on the other side.	UMLS:C4025171	hp.json	Trapezoidal vertebral bodies|Trapezoidal shaped vertebral bodies	http://purl.obolibrary.org/obo/HP_0005621		
HP:0030633	biolink:PhenotypicFeature	Perifoveal ring of hyperautofluorescence surrounded by normal autofluorescence		UMLS:C4073103	hp.json		http://purl.obolibrary.org/obo/HP_0030633		
HP:0005622	biolink:PhenotypicFeature	Broad long bones	Increased cross-section (diameter) of the long bones. Note that widening may primarily affect specific regions of long bones (e.g., diaphysis or metaphysis), but this should be coded separately.	UMLS:C4021630	hp.json	Broad long bones|Wide long bones|Widened long bones	http://purl.obolibrary.org/obo/HP_0005622		
HP:0005623	biolink:PhenotypicFeature	Absent ossification of calvaria	Absent ossification of the calvaria (vault of the skull).	UMLS:C4021629	hp.json	Absent bone maturation of skullcap|Absent ossification of skull vault	http://purl.obolibrary.org/obo/HP_0005623		
HP:0030634	biolink:PhenotypicFeature	Perifoveal ring of hyperautofluorescence surrounded by abnormal autofluorescence		UMLS:C4073104	hp.json		http://purl.obolibrary.org/obo/HP_0030634		
CHEBI:22723	biolink:ChemicalSubstance	benzoic acids	Any aromatic carboxylic acid that consists of benzene in which at least a single hydrogen has been substituted by a carboxy group.		hp.json		http://purl.obolibrary.org/obo/CHEBI_22723		3_STAR
HP:0030639	biolink:PhenotypicFeature	Congenital stationary night blindness with abnormal fundus		UMLS:C4073106	hp.json		http://purl.obolibrary.org/obo/HP_0030639		
CHEBI:22727	biolink:ChemicalSubstance	benzopyran		Wikipedia:Benzopyran	hp.json	benzopyrans	http://purl.obolibrary.org/obo/CHEBI_22727		3_STAR
CHEBI:22728	biolink:ChemicalSubstance	benzopyrrole			hp.json	benzopyrroles	http://purl.obolibrary.org/obo/CHEBI_22728		3_STAR
HP:0030640	biolink:PhenotypicFeature	Complete congenital stationary night blindness		UMLS:C4048798	hp.json		http://purl.obolibrary.org/obo/HP_0030640		
HP:0030641	biolink:PhenotypicFeature	Incomplete congenital stationary night blindness		UMLS:C4073107	hp.json		http://purl.obolibrary.org/obo/HP_0030641		
HP:0005639	biolink:PhenotypicFeature	Hyperextensible hand joints	The ability of the joints of the hand to move beyond their normal range of motion.	UMLS:C1856877	hp.json		http://purl.obolibrary.org/obo/HP_0005639		
UBERON:0005563	biolink:AnatomicalEntity	trigeminal neural crest	Cranial neural crest which gives rise to the trigeminal ganglion.	VHOG:0000269|EMAPA:16170|ZFA:0000080|EFO:0003484|TAO:0000080|EHDAA2:0002083|EHDAA:667	hp.json		http://purl.obolibrary.org/obo/UBERON_0005563		efo_slim|vertebrate_core
HP:0030646	biolink:PhenotypicFeature	Peripheral		UMLS:C0205100|SNOMEDCT_US:14414005	hp.json		http://purl.obolibrary.org/obo/HP_0030646		
UBERON:0005562	biolink:AnatomicalEntity	thymus primordium	A small outgrowth of the pharyngeal epithelium that is the site of lymphocyte cell production[ZFA]. [PMID].	TAO:0001077|EFO:0003622|EHDAA2:0002023|EHDAA:2969|EMAPA:17523|ZFA:0001077	hp.json	thymic primordium|thymic rudiment	http://purl.obolibrary.org/obo/UBERON_0005562		efo_slim|vertebrate_core
HP:0030647	biolink:PhenotypicFeature	Paracentral		UMLS:C4073110	hp.json		http://purl.obolibrary.org/obo/HP_0030647		
HP:0030648	biolink:PhenotypicFeature	Midperipheral		UMLS:C4073111	hp.json	Mid-peripheral	http://purl.obolibrary.org/obo/HP_0030648		
HP:0030649	biolink:PhenotypicFeature	Pericentral		UMLS:C4073112	hp.json		http://purl.obolibrary.org/obo/HP_0030649		
HP:0005638	biolink:PhenotypicFeature	Decreased anterioposterior diameter of lumbar vertebral bodies		UMLS:C4025168	hp.json		http://purl.obolibrary.org/obo/HP_0005638		
HP:0030642	biolink:PhenotypicFeature	Fundus albipunctatus		MSH:C562733|SNOMEDCT_US:68222009|UMLS:C0311338	hp.json		http://purl.obolibrary.org/obo/HP_0030642		
HP:0005632	biolink:PhenotypicFeature	Absent forearm		UMLS:C1408532	hp.json	Absent forearm|Absent forearms	http://purl.obolibrary.org/obo/HP_0005632		
HP:0030643	biolink:PhenotypicFeature	Vitelliform-like retinal lesions		UMLS:C4073108	hp.json		http://purl.obolibrary.org/obo/HP_0030643		
HP:0030644	biolink:PhenotypicFeature	Blind-spot enlargment		UMLS:C4073109	hp.json	Blind spot enlargment	http://purl.obolibrary.org/obo/HP_0030644		
HP:0030645	biolink:PhenotypicFeature	Central	Applies to an abnormality that is located close to the median plane or midline of the body or of the referenced structure.	UMLS:C0205099|SNOMEDCT_US:26216008	hp.json		http://purl.obolibrary.org/obo/HP_0030645		
UBERON:0005568	biolink:AnatomicalEntity	rhombomere 1 roof plate	A rhombomere roof plate that is part of a rhombomere 1.	ZFA:0001033|EMAPA:16483|DMBA:16916|TAO:0001033|EHDAA2:0001645	hp.json	roof plate rhombomere 1	http://purl.obolibrary.org/obo/UBERON_0005568		vertebrate_core
UBERON:0005567	biolink:AnatomicalEntity	rhombomere 1 lateral wall	A rhombomere lateral wall that is part of a rhombomere 1.	EHDAA2:0001641|EMAPA:16482|TAO:0000781|ZFA:0000781	hp.json	lateral wall rhombomere 1	http://purl.obolibrary.org/obo/UBERON_0005567		vertebrate_core
UBERON:0005565	biolink:AnatomicalEntity	facio-acoustic neural crest	Cranial neural crest that gives rise to the facio-acoustic ganglion.	EHDAA2:0000492|VHOG:0000268|EHDAA:658|EMAPA:16312|ZFA:0000762|TAO:0000762	hp.json	facio acoustic neural crest	http://purl.obolibrary.org/obo/UBERON_0005565		vertebrate_core
UBERON:0005564	biolink:AnatomicalEntity	gonad primordium	Portion of tissue that gives rise to the immature gonad.	ZFA:0001262|TAO:0001262|EFO:0003651|EHDAA:5927|RETIRED_EHDAA2:0002148|EMAPA:17204|WBbt:0008366	hp.json	primitive gonad|immature gonad|primitive gonad|immature gonad|future gonad|future gonad|undifferentiated gonad|gonadal primordium	http://purl.obolibrary.org/obo/UBERON_0005564		efo_slim|vertebrate_core|grouping_class
NCBITaxon:9989	biolink:OrganismalEntity	Rodentia		GC_ID:1	hp.json	rodent|rodents	http://purl.obolibrary.org/obo/NCBITaxon_9989		
HP:0003027	biolink:PhenotypicFeature	Mesomelia	Shortening of the middle parts of the limbs (forearm and lower leg) in relation to the upper and terminal segments.	UMLS:C0549306	hp.json	Mesomelic shortening of limbs|Mesomelic limb shortening|Symmetric mesomelic limb shortness|Disproportionately short middle portion of limb	http://purl.obolibrary.org/obo/HP_0003027		
HP:0003026	biolink:PhenotypicFeature	Short long bone	One or more abnormally short long bone.	UMLS:C1854912	hp.json	Long bone shortening|Short long bone|Short tubular bones|shortened long tubular bones	http://purl.obolibrary.org/obo/HP_0003026		
HP:0003025	biolink:PhenotypicFeature	Metaphyseal irregularity	Irregularity of the normally smooth surface of the metaphyses.	UMLS:C1838662	hp.json	Frayed, irregular metaphyses|Metaphyseal fraying|Frayed, irregular, metaphyses|Irregular wide portion of a long bone|Irregular metaphyses|Metaphyseal irregularities	http://purl.obolibrary.org/obo/HP_0003025		
HP:0005686	biolink:PhenotypicFeature	Patchy osteosclerosis	Patchy (irregular) increase in bone density. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C1855845	hp.json	Patchy increase of bone mineral density|Uneven increase in bone density	http://purl.obolibrary.org/obo/HP_0005686		
HP:0005687	biolink:PhenotypicFeature	Deformed humeral heads		UMLS:C4025154	hp.json	Deformed head of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0005687		
HP:0005688	biolink:PhenotypicFeature	Dysplastic distal thumb phalanges with a central hole		UMLS:C4025153	hp.json		http://purl.obolibrary.org/obo/HP_0005688		
HP:0003029	biolink:PhenotypicFeature	Enlargement of the ankles		UMLS:C1838664	hp.json	Enlargement of the ankles	http://purl.obolibrary.org/obo/HP_0003029		
HP:0003028	biolink:PhenotypicFeature	Abnormality of the ankles		UMLS:C4025660	hp.json	Abnormality of the ankles	http://purl.obolibrary.org/obo/HP_0003028		hposlim_core
HP:0005689	biolink:PhenotypicFeature	Dermatoglyphic ridges abnormal		UMLS:C4025152	hp.json		http://purl.obolibrary.org/obo/HP_0005689		
HP:0005682	biolink:PhenotypicFeature	Talocalcaneal synostosis		UMLS:C4255214|UMLS:C4025155	hp.json	Fusion of foot joint|Fusion of the subtalar joint	http://purl.obolibrary.org/obo/HP_0005682		
HP:0005684	biolink:PhenotypicFeature	Distal arthrogryposis	An inherited primary limb malformation disorder characterized by congenital contractures of two or more different body areas and without primary neurologic and/or muscle disease that affects limb function.	UMLS:C0265213|SNOMEDCT_US:24269006	hp.json		http://purl.obolibrary.org/obo/HP_0005684		
HP:0003023	biolink:PhenotypicFeature	Bowing of limbs due to multiple fractures	Curvature of the shafts of the long bones due to multiple fractures.	UMLS:C1850178	hp.json	Bowed limbs due to multiple fractures	http://purl.obolibrary.org/obo/HP_0003023		
HP:0003022	biolink:PhenotypicFeature	Hypoplasia of the ulna	Underdevelopment of the ulna.	UMLS:C1862132|MSH:C538069|UMLS:C1860614	hp.json	Hypoplastic ulna|Short ulnae|Underdeveloped ulna|Ulnar hypoplasia|Short ulna|Underdeveloped inner large forearm bone	http://purl.obolibrary.org/obo/HP_0003022		hposlim_core
HP:0003021	biolink:PhenotypicFeature	Metaphyseal cupping	Metaphyseal cupping refers to an inward bulging of the metaphyseal profile giving the metaphysis a cup-like appearance.	UMLS:C1837082	hp.json		http://purl.obolibrary.org/obo/HP_0003021		
HP:0005680	biolink:PhenotypicFeature	Tongue-like lumbar vertebral deformities	A tongue-like protusion from the anterior aspect of lumbar vertebral bodies.	UMLS:C4025156	hp.json		http://purl.obolibrary.org/obo/HP_0005680		
HP:0003020	biolink:PhenotypicFeature	Enlargement of the wrists		UMLS:C1838663	hp.json	Enlargement of the wrists	http://purl.obolibrary.org/obo/HP_0003020		
HP:0005681	biolink:PhenotypicFeature	Juvenile rheumatoid arthritis		SNOMEDCT_US:410795001|UMLS:C3714757	hp.json	Juvenile idiopathic arthritis|Rheumatoid arthritis, juvenile|Juvenile RA	http://purl.obolibrary.org/obo/HP_0005681		
HP:0003038	biolink:PhenotypicFeature	Fibular hypoplasia	Underdevelopment of the fibula.	UMLS:C1832119	hp.json	Hypoplastic fibula|Short fibulae|Short calf bone|Short fibula	http://purl.obolibrary.org/obo/HP_0003038		hposlim_core
HP:0003037	biolink:PhenotypicFeature	Enlarged joints	Increase in size of one or more joints.	UMLS:C1859111	hp.json	Prominent joints|Enlarged joints	http://purl.obolibrary.org/obo/HP_0003037		hposlim_core
HP:0005694	biolink:PhenotypicFeature	Partial fusion of proximal row of carpal bones		UMLS:C3152021	hp.json	Partial fusion of innermost row of wrist bones	http://purl.obolibrary.org/obo/HP_0005694		
CHEBI:22712	biolink:ChemicalSubstance	benzenes	Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives.		hp.json		http://purl.obolibrary.org/obo/CHEBI_22712		3_STAR
HP:0005696	biolink:PhenotypicFeature	Postaxial polydactyly type A	Supernumerary digits located at the ulnar side of the hand with a complete extra finger and extra metacarpal.	UMLS:C3887487|MSH:C562429|SNOMEDCT_US:715704001	hp.json		http://purl.obolibrary.org/obo/HP_0005696		
HP:0003034	biolink:PhenotypicFeature	Diaphyseal sclerosis	An elevation in bone density in one or more diaphyses. Sclerosis is normally detected on a radiograph as an area of increased opacity.	SNOMEDCT_US:34643004|MSH:D003966|UMLS:C0011989|SNOMEDCT_US:318761000119105	hp.json	Craniodiaphyseal osteosclerosis|Increased bone density in shaft of long bone|Diaphyseal osteosclerosis	http://purl.obolibrary.org/obo/HP_0003034		
CHEBI:22718	biolink:ChemicalSubstance	benzoates	A monocarboxylic acid anion obtained by deprotonation of the carboxy group of any benzoic acid.		hp.json	benzoate anion	http://purl.obolibrary.org/obo/CHEBI_22718		3_STAR
HP:0003031	biolink:PhenotypicFeature	Ulnar bowing	Bending of the diaphysis (shaft) of the ulna.	UMLS:C1865847	hp.json	Curved ulna|Bowed ulna|Curving of inner forearm bone	http://purl.obolibrary.org/obo/HP_0003031		hposlim_core
HP:0005692	biolink:PhenotypicFeature	Joint hyperflexibility	Increased mobility and flexibility in the joint due to the tension in tissues such as ligaments and muscles.	UMLS:C3553764	hp.json	Joints move beyond expected range of motion	http://purl.obolibrary.org/obo/HP_0005692		
HP:0003005	biolink:PhenotypicFeature	Ganglioneuroma	A benign neoplasm that usually arises from the sympathetic trunk in the mediastinum, representing a tumor of the sympathetic nerve fibers arising from neural crest cells.	MSH:D005729|SNOMEDCT_US:116371000119107|SNOMEDCT_US:53801007|UMLS:C0017075|SNOMEDCT_US:128919000	hp.json		http://purl.obolibrary.org/obo/HP_0003005		
HP:0003003	biolink:PhenotypicFeature	Colon cancer		MSH:D003110|SNOMEDCT_US:363406005|UMLS:C0007102	hp.json	Colon cancer	http://purl.obolibrary.org/obo/HP_0003003		
HP:0003002	biolink:PhenotypicFeature	Breast carcinoma	The presence of a carcinoma of the breast.	NCIT:C2916|MSH:D001943|UMLS:C0678222|SNOMEDCT_US:254838004	hp.json	Breast cancer	http://purl.obolibrary.org/obo/HP_0003002		
HP:0003009	biolink:PhenotypicFeature	Enhanced neurotoxicity of vincristine		UMLS:C4025661	hp.json		http://purl.obolibrary.org/obo/HP_0003009		
HP:0005665	biolink:PhenotypicFeature	Massively thickened long bone cortices	Extreme thickening of the cortex of long bones.	UMLS:C4025160	hp.json		http://purl.obolibrary.org/obo/HP_0005665		
HP:0003006	biolink:PhenotypicFeature	Neuroblastoma	Neuroblastoma is a solid tumor that originate in neural crest cells of the sympathetic nervous system. Most neuroblastomas originate in the abdomen, and most abdominal neuroblastomas originate in the adrenal gland. Neuroblastomas can also originate in the thorax, usually in the posterior mediastinum.	SNOMEDCT_US:432328008|MSH:D009447|SNOMEDCT_US:87364003|UMLS:C0027819|NCIT:C3270	hp.json	Cancer of early nerve cells	http://purl.obolibrary.org/obo/HP_0003006		
HP:0005667	biolink:PhenotypicFeature	Os odontoideum	Separation of the odontoid process from the body of the axis.	SNOMEDCT_US:445242006|UMLS:C2919848	hp.json		http://purl.obolibrary.org/obo/HP_0005667		
HP:0005661	biolink:PhenotypicFeature	Salmonella osteomyelitis	Osteomyelitis caused by infection with the bacteria, salmonella.	SNOMEDCT_US:6803002|UMLS:C0152491	hp.json	Salmonella bone infection	http://purl.obolibrary.org/obo/HP_0005661		
HP:0003001	biolink:PhenotypicFeature	Glomus jugular tumor		SNOMEDCT_US:32037004|SNOMEDCT_US:127030001|MSH:D005925|UMLS:C0017671	hp.json	Glomus jugular tumour|Glomus jugulare tumours|Glomus jugulare tumors|Glomus jugulare tumour|Glomus jugulare tumor	http://purl.obolibrary.org/obo/HP_0003001		
HP:0003016	biolink:PhenotypicFeature	Metaphyseal widening	Abnormal widening of the metaphyseal regions of long bones.	UMLS:C1849039	hp.json	Widened metaphyses|Widened long bone metaphyses|Wide metaphyses|Broad wide portion of long bone	http://purl.obolibrary.org/obo/HP_0003016		
HP:0005679	biolink:PhenotypicFeature	Dupuytren contracture	An abnormality of the hand resulting from contracture of the palmar fascia with a fixed flexion deformity of the metacarpophalangeal (MCP) joints and the proximal interphalangeal (PIP) joints.	SNOMEDCT_US:274142002|UMLS:C0013312|MSH:D004387|SNOMEDCT_US:203047009|SNOMEDCT_US:410813000|SNOMEDCT_US:203045001	hp.json		http://purl.obolibrary.org/obo/HP_0005679		
GO:0045905	biolink:BiologicalProcess	positive regulation of translational termination	Any process that activates or increases the frequency, rate or extent of translational termination.		hp.json	activation of translational termination|stimulation of translational termination|upregulation of translational termination|up-regulation of translational termination|up regulation of translational termination	http://purl.obolibrary.org/obo/GO_0045905		
HP:0030602	biolink:PhenotypicFeature	Abnormal fundus autofluorescence imaging	Fundus autofluorescence (FAF) is a non-invasive retinal imaging modality used in clinical practice to provide a density map of lipofuscin, the predominant ocular fluorophore, in the retinal pigment epithelium. Autofluorescent patterns result from the complex interaction of fluorophores such a lipofuscin, which release an autofluorescent signal, and elements such as melanin and rhodopsin, which absorb the excitation beam and attenuate autofluorescence. Other structures such as retinal vessels and the crystalline lens may also influence autofluorescence through blocking and interference.	UMLS:C4073073	hp.json		http://purl.obolibrary.org/obo/HP_0030602		
HP:0003015	biolink:PhenotypicFeature	Flared metaphysis	The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones.	UMLS:C1850135	hp.json	Metaphyseal flaring of long bones|Flared, widened metaphyses|Flared wide portion of long bone|marked metaphyseal flaring of long bones|Metaphyseal flaring|Metaphyseal splaying|Metaphyses flared|Splayed metaphyses	http://purl.obolibrary.org/obo/HP_0003015		
HP:0030603	biolink:PhenotypicFeature	Abnormal optical coherence tomography		UMLS:C3665728	hp.json		http://purl.obolibrary.org/obo/HP_0030603		
HP:0030604	biolink:PhenotypicFeature	Abnormal fundus fluorescein angiography	An abnormality observed by retinal fluorescein angiography, which involves the intravenous injection of fluorescein dye followed by fluorescent imaging of the fundus immediately after injection and for up to ten minutes thereafter. It can be used to study various retinal abnormalities including especially anomalies of the choroidal and retinal circulation.	UMLS:C4073074	hp.json		http://purl.obolibrary.org/obo/HP_0030604		
PATO:0050000	biolink:NamedThing	rate of occurence	The number of repeated events per unit time, occurring in a repeating series. (e.g. the number of heart beats occurring over 1 minute)		hp.json		http://purl.obolibrary.org/obo/PATO_0050000		
HP:0003013	biolink:PhenotypicFeature	Bulging epiphyses	A morphological abnormality of epiphyses whereby they are abnormally outwardly curving (protuberant).	UMLS:C1833329	hp.json	Bulging end part of bone	http://purl.obolibrary.org/obo/HP_0003013		
GO:0045904	biolink:BiologicalProcess	negative regulation of translational termination	Any process that stops, prevents, or reduces the frequency, rate or extent of translational termination.		hp.json	down-regulation of translational termination|down regulation of translational termination|inhibition of translational termination|downregulation of translational termination	http://purl.obolibrary.org/obo/GO_0045904		
HP:0030605	biolink:PhenotypicFeature	Abnormal indocyanine green angiography		UMLS:C4073075	hp.json		http://purl.obolibrary.org/obo/HP_0030605		
GO:0045901	biolink:BiologicalProcess	positive regulation of translational elongation	Any process that activates or increases the frequency, rate or extent of translational elongation.		hp.json	upregulation of translational elongation|up regulation of translational elongation|stimulation of translational elongation|activation of translational elongation|up-regulation of translational elongation	http://purl.obolibrary.org/obo/GO_0045901		
HP:0003019	biolink:PhenotypicFeature	Abnormality of the wrist	Abnormality of the wrist, the structure connecting the hand and the forearm.	UMLS:C4021744	hp.json	Abnormality of the wrist|Abnormalities of the wrists	http://purl.obolibrary.org/obo/HP_0003019		hposlim_core
HP:0005676	biolink:PhenotypicFeature	Rudimentary postaxial polydactyly of hands		UMLS:C4025158	hp.json		http://purl.obolibrary.org/obo/HP_0005676		
GO:0045900	biolink:BiologicalProcess	negative regulation of translational elongation	Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.		hp.json	downregulation of translational elongation|down regulation of translational elongation|inhibition of translational elongation|down-regulation of translational elongation	http://purl.obolibrary.org/obo/GO_0045900		
HP:0005678	biolink:PhenotypicFeature	Anterior atlanto-occipital dislocation		UMLS:C4025157	hp.json		http://purl.obolibrary.org/obo/HP_0005678		
HP:0030601	biolink:PhenotypicFeature	Abnormal posterior segment imaging		UMLS:C4073072	hp.json		http://purl.obolibrary.org/obo/HP_0030601		
HP:0005671	biolink:PhenotypicFeature	Bilateral intracerebral calcifications	Deposition of calcium salts on both sides of the brain.	UMLS:C4025159	hp.json	Bilateral intracranial calcifications	http://purl.obolibrary.org/obo/HP_0005671		
HP:0030606	biolink:PhenotypicFeature	Abnormal OCT-measured macular thickness		UMLS:C4073076	hp.json		http://purl.obolibrary.org/obo/HP_0030606		
HP:0030607	biolink:PhenotypicFeature	Reduced OCT-measured macular thickness		UMLS:C4073077	hp.json		http://purl.obolibrary.org/obo/HP_0030607		
HP:0003011	biolink:PhenotypicFeature	Abnormality of the musculature	Abnormality originating in one or more muscles, i.e., of the set of muscles of body.	UMLS:C4021745	hp.json	Muscular abnormality	http://purl.obolibrary.org/obo/HP_0003011		
HP:0003010	biolink:PhenotypicFeature	Prolonged bleeding time	Prolongation of the time taken for a standardized skin cut of fixed depth and length to stop bleeding.	UMLS:C0151529	hp.json	Increased bleeding time|Prolonged bleeding time	http://purl.obolibrary.org/obo/HP_0003010		
HP:0030608	biolink:PhenotypicFeature	Increased OCT-measured macular thickness		UMLS:C4073078	hp.json		http://purl.obolibrary.org/obo/HP_0030608		
HP:0030609	biolink:PhenotypicFeature	Photoreceptor layer loss on macular OCT	Loss of the outer nuclear layer (photoreceptor layer) as assessed by ocular coherence tomography.	UMLS:C4073079	hp.json		http://purl.obolibrary.org/obo/HP_0030609		
GO:0043292	biolink:CellularComponent	contractile fiber	Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.		hp.json	contractile fibre	http://purl.obolibrary.org/obo/GO_0043292		
CHEBI:19168	biolink:ChemicalSubstance	17-oxo steroid	Any  oxo steroid carrying the oxo group at position 17.		hp.json	17-keto steroid|17-oxo steroids|17-oxosteroids|17-ketosteroids|17-ketosteroid|17-oxosteroid|17-keto steroids|a 17-oxo steroid	http://purl.obolibrary.org/obo/CHEBI_19168		3_STAR
CHEBI:46787	biolink:ChemicalSubstance	solvent	A liquid that can dissolve other substances (solutes) without any change in their chemical composition.	Wikipedia:Solvent	hp.json	solvant|solvents|Loesungsmittel	http://purl.obolibrary.org/obo/CHEBI_46787		3_STAR
HGNC:4116	biolink:Gene	GALE (human)	A protein coding gene GALE in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4116		
UBERON:0005502	biolink:AnatomicalEntity	rhombomere roof plate		EMAPA:35367|ZFA:0001311|EMAPA:32824|TAO:0001311|VHOG:0001018	hp.json	future hindbrain roof plate|roof plate rhombomeres|roof plate rhombomere|roof plate hindbrain|roof plate rhombomere region	http://purl.obolibrary.org/obo/UBERON_0005502		
UBERON:0005501	biolink:AnatomicalEntity	rhombomere lateral wall	A neural tube lateral wall that is part of a rhombomere.	EMAPA:32819|EMAPA:35364	hp.json	future hindbrain lateral wall	http://purl.obolibrary.org/obo/UBERON_0005501		
CHEBI:46775	biolink:ChemicalSubstance	N-alkylpyrrolidine			hp.json	N-alkylpyrrolidines	http://purl.obolibrary.org/obo/CHEBI_46775		3_STAR
UBERON:0029503	biolink:AnatomicalEntity	sacral spinal cord gray matter		BIRNLEX:1491	hp.json	sacral spinal cord gray matter|sacral spinal cord gray matter	http://purl.obolibrary.org/obo/UBERON_0029503		
CHEBI:46761	biolink:ChemicalSubstance	dipeptide	Any molecule that contains two amino-acid residues connected by peptide linkages.	KEGG:C00107	hp.json	Dipeptid|Dipeptide|dipeptides	http://purl.obolibrary.org/obo/CHEBI_46761		3_STAR
CHEBI:46767	biolink:ChemicalSubstance	pyrrolidinecarboxylic acid			hp.json	pyrrolidinecarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_46767		3_STAR
GO:0021915	biolink:BiologicalProcess	neural tube development	The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.		hp.json		http://purl.obolibrary.org/obo/GO_0021915		
PATO:0001018	biolink:NamedThing	physical quality	A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities.	Wikipedia:Physical_property	hp.json	relational physical quality	http://purl.obolibrary.org/obo/PATO_0001018		attribute_slim
HP:0005606	biolink:PhenotypicFeature	Hyperpigmented nevi and streak		UMLS:C3805692	hp.json		http://purl.obolibrary.org/obo/HP_0005606		
HP:0005607	biolink:PhenotypicFeature	Abnormal tracheobronchial morphology		Fyler:4232|UMLS:C4021631	hp.json	Tracheobronchial anomalies	http://purl.obolibrary.org/obo/HP_0005607		
PATO:0001019	biolink:NamedThing	mass density	A physical quality which inheres in a bearer by virtue of some influence is exerted by the bearer's mass per unit size.		hp.json	density	http://purl.obolibrary.org/obo/PATO_0001019		scalar_slim|attribute_slim
HP:0005608	biolink:PhenotypicFeature	Bilobate gallbladder	The presence of a bilobed gallbladder, related to a duplication of the gallbladder primordium.	UMLS:C1846422	hp.json	Gallbladder duplication|Bilobed gallbladder|Double gallbladder	http://purl.obolibrary.org/obo/HP_0005608		
HP:0005609	biolink:PhenotypicFeature	Gallbladder dysfunction		SNOMEDCT_US:51047007|UMLS:C0232769	hp.json	Gallbladder dysfunction	http://purl.obolibrary.org/obo/HP_0005609		
GO:0021905	biolink:BiologicalProcess	forebrain-midbrain boundary formation	The process whose specific outcome is the creation of the forebrain-midbrain boundary.		hp.json		http://purl.obolibrary.org/obo/GO_0021905		
HP:0005602	biolink:PhenotypicFeature	Progressive vitiligo		UMLS:C3806428	hp.json		http://purl.obolibrary.org/obo/HP_0005602		
GO:0021906	biolink:BiologicalProcess	hindbrain-spinal cord boundary formation	The process whose specific outcome is the formation of the hindbrain-spinal cord boundary.		hp.json		http://purl.obolibrary.org/obo/GO_0021906		
HP:0005603	biolink:PhenotypicFeature	Numerous congenital melanocytic nevi		UMLS:C3806415	hp.json		http://purl.obolibrary.org/obo/HP_0005603		
HP:0005605	biolink:PhenotypicFeature	Large cafe-au-lait macules with irregular margins	Large hypermelanotic macules with jagged borders.	UMLS:C4025174	hp.json		http://purl.obolibrary.org/obo/HP_0005605		
HP:0005600	biolink:PhenotypicFeature	Congenital giant melanocytic nevus	The giant congenital nevus is greater than 8 cm in size, pigmented and often hairy. A giant congenital nevus is smaller in infants and children, but it usually continues to grow with the child.	MSH:C536819|SNOMEDCT_US:10291008|SNOMEDCT_US:254815002|UMLS:C1842036	hp.json	Giant pigmented hairy nevus|Giant pigmented mole|Giant pigmented nevus	http://purl.obolibrary.org/obo/HP_0005600		
GO:0021903	biolink:BiologicalProcess	rostrocaudal neural tube patterning	The process in which the neural tube is divided into specific regions along the rostrocaudal axis.		hp.json	anterior-posterior neural tube patterning	http://purl.obolibrary.org/obo/GO_0021903		
HP:0005617	biolink:PhenotypicFeature	Bilateral camptodactyly		UMLS:C4021830	hp.json		http://purl.obolibrary.org/obo/HP_0005617		
HP:0005619	biolink:PhenotypicFeature	Thoracolumbar kyphosis	Hyperconvexity of the thoracolumbar spine producing a rounded or humped appearance.	UMLS:C1855418	hp.json	Thoracolumbar gibbus deformity|Thoracolumbar gibbus	http://purl.obolibrary.org/obo/HP_0005619		
HP:0005613	biolink:PhenotypicFeature	Aplasia/hypoplasia of the femur	Absence or underdevelopment of the femur.	UMLS:C1851310	hp.json	Absent/small thighbone|Hypoplastic to absent femora|Hypoplastic/aplastic femora|Absent/underdeveloped thighbone	http://purl.obolibrary.org/obo/HP_0005613		
PATO:0001020	biolink:NamedThing	damage	A structural quality inhering in a bearer by virtue of whether the bearer has been harmed or injured or spoiled.		hp.json		http://purl.obolibrary.org/obo/PATO_0001020		attribute_slim
HP:0005616	biolink:PhenotypicFeature	Accelerated skeletal maturation	An abnormally increased rate of skeletal maturation. Accelerated skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body.	UMLS:C0545053|SNOMEDCT_US:123982003	hp.json	Advanced bone age|Early bone maturation	http://purl.obolibrary.org/obo/HP_0005616		
PATO:0001025	biolink:NamedThing	pressure	A physical quality that inheres in a bearer by virtue of the bearer's amount of force per unit area it exerts.		hp.json		http://purl.obolibrary.org/obo/PATO_0001025		attribute_slim
HP:0005612	biolink:PhenotypicFeature	Arthrogryposis-like hand anomaly		UMLS:C4025173	hp.json		http://purl.obolibrary.org/obo/HP_0005612		
PATO:0001031	biolink:NamedThing	elasticity	A physical quality inhering in a bearer by virtue of the bearer's disposition to recover its size and shape after deformation in any way.		hp.json		http://purl.obolibrary.org/obo/PATO_0001031		scalar_slim|disposition_slim|attribute_slim
CHEBI:20106	biolink:ChemicalSubstance	vanillylmandelic acid	An aromatic ether that is the 3-O-methyl ether of 3,4-dihydroxymandelic acid.	CAS:55-10-7|PMID:24327171|CAS:55-10-7|HMDB:HMDB0000291|PMID:23399766|PMID:13756637|MetaCyc:VANILLYL_MANDELATE|Beilstein:2213227|Reaxys:2213227|PMID:23830883|KEGG:C05584|PMID:23112240|Wikipedia:Vanillylmandelic_acid	hp.json	hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid|Vanillylmandelic acid|Vanilmandelic acid|2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid|3-methoxy-4-hydroxymandelic acid	http://purl.obolibrary.org/obo/CHEBI_20106		3_STAR
CHEBI:46723	biolink:ChemicalSubstance	phosphate mineral			hp.json		http://purl.obolibrary.org/obo/CHEBI_46723		
PATO:0001043	biolink:NamedThing	susceptibility toward	A quality inhering in an entity by virtue of the bearer's propensity to resist an external stimulus.		hp.json	susceptibility	http://purl.obolibrary.org/obo/PATO_0001043		disposition_slim|relational_slim|attribute_slim
PATO:0001046	biolink:NamedThing	resistance to	A quality inhering in a bearer by virtue of the bearer's disposition to resist to a stimulus.		hp.json	resistance	http://purl.obolibrary.org/obo/PATO_0001046		scalar_slim|disposition_slim|relational_slim|attribute_slim
GO:0043455	biolink:BiologicalProcess	regulation of secondary metabolic process	Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.		hp.json	regulation of secondary metabolism	http://purl.obolibrary.org/obo/GO_0043455		
CL:0005012	biolink:Cell	multi-ciliated epithelial cell	A ciliated epithelial cell with many cilium.		hp.json	MCC|multi-ciliated cell|multiciliated cell|multiciliated epithelial cell	http://purl.obolibrary.org/obo/CL_0005012		
GO:0043467	biolink:BiologicalProcess	regulation of generation of precursor metabolites and energy	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.		hp.json		http://purl.obolibrary.org/obo/GO_0043467		
CL:0005026	biolink:Cell	hepatoblast	Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants.		hp.json		http://purl.obolibrary.org/obo/CL_0005026		
CL:0005020	biolink:Cell	lymphangioblast	Lymphatic progenitor cells.		hp.json		http://purl.obolibrary.org/obo/CL_0005020		
GO:0031452	biolink:BiologicalProcess	negative regulation of heterochromatin assembly	Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation.		hp.json	down regulation of heterochromatin formation|downregulation of heterochromatin formation|inhibition of heterochromatin formation|negative regulation of heterochromatin formation|down-regulation of heterochromatin formation	http://purl.obolibrary.org/obo/GO_0031452		
GO:0031453	biolink:BiologicalProcess	positive regulation of heterochromatin assembly	Any process that activates or increases the frequency, rate or extent of heterochromatin formation.		hp.json	upregulation of heterochromatin formation|up-regulation of heterochromatin formation|up regulation of heterochromatin formation|activation of heterochromatin formation|positive regulation of heterochromatin formation|stimulation of heterochromatin formation	http://purl.obolibrary.org/obo/GO_0031453		
CL:0005022	biolink:Cell	vascular lymphangioblast	Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells.		hp.json	parachordal lymphangioblast	http://purl.obolibrary.org/obo/CL_0005022		
GO:0043470	biolink:BiologicalProcess	regulation of carbohydrate catabolic process	Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates.		hp.json		http://purl.obolibrary.org/obo/GO_0043470		
GO:0031445	biolink:BiologicalProcess	regulation of heterochromatin assembly	Any process that modulates the frequency, rate, extent or location of heterochromatin formation.		hp.json	regulation of heterochromatin formation	http://purl.obolibrary.org/obo/GO_0031445		
GO:0006487	biolink:BiologicalProcess	protein N-linked glycosylation	A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan.	RESID:AA0156|RESID:AA0151|RESID:AA0327	hp.json	N-glycan biosynthesis|protein amino acid N-linked glycosylation|N-glycan metabolism	http://purl.obolibrary.org/obo/GO_0006487		
GO:0006486	biolink:BiologicalProcess	protein glycosylation	A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.		hp.json	protein amino acid glycosylation|protein-carbohydrate complex assembly	http://purl.obolibrary.org/obo/GO_0006486		goslim_generic|goslim_yeast|prokaryote_subset|goslim_pombe
GO:0043471	biolink:NamedThing	regulation of cellular carbohydrate catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0043471		
GO:0043474	biolink:BiologicalProcess	pigment metabolic process involved in pigmentation	The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell.		hp.json	pigment metabolism during pigmentation|pigment metabolic process during pigmentation	http://purl.obolibrary.org/obo/GO_0043474		
GO:0043473	biolink:BiologicalProcess	pigmentation	The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.		hp.json		http://purl.obolibrary.org/obo/GO_0043473		goslim_chembl|goslim_pir
HP:0410005	biolink:PhenotypicFeature	Cleft hard palate		UMLS:C0432090|SNOMEDCT_US:448915004	hp.json	Cleft of hard palate|Cleft bony palate	http://purl.obolibrary.org/obo/HP_0410005		
HP:0410004	biolink:PhenotypicFeature	obsolete Cleft secondary palate			hp.json		http://purl.obolibrary.org/obo/HP_0410004		
HP:0410003	biolink:PhenotypicFeature	Cleft maxillary alveolus	Alveolar cleft is a tornado-shaped bone defect in the maxillary arch. Alveolar cleft occurs in response to divergence from normal development during frontonasal prominence growth, contact, and fusion. The most common alveolar portion of the cleft is located between the lateral incisor and the canine.	UMLS:C4280276|UMLS:C0432084|SNOMEDCT_US:109546001	hp.json	Cleft primary palate|Cleft alveolar process of maxilla|Cleft anterior maxilla|Alveolar cleft	http://purl.obolibrary.org/obo/HP_0410003		
HP:0410009	biolink:PhenotypicFeature	Abnormality of the somatic nervous system	Any abnormality of the part of the peripheral nervous system associated with sensation and skeletal muscle voluntary control of body movements.	UMLS:C4073188	hp.json		http://purl.obolibrary.org/obo/HP_0410009		
HP:0410008	biolink:PhenotypicFeature	Abnormality of the peripheral nervous system	Any abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord.	UMLS:C4073187	hp.json	Abnormality of the peripheral nervous system	http://purl.obolibrary.org/obo/HP_0410008		
HP:0410007	biolink:PhenotypicFeature	obsolete Abnormality of cartilage morphology			hp.json		http://purl.obolibrary.org/obo/HP_0410007		
HP:0410006	biolink:PhenotypicFeature	Abnormality of ophthalmic artery	Abnormality of the first branch of the internal carotid artery.	UMLS:C4073185	hp.json	Ophthalmic artery anomaly	http://purl.obolibrary.org/obo/HP_0410006		
HP:0410000	biolink:PhenotypicFeature	Abnormal vomer morphology	An abnormality of the vomer.	UMLS:C4020914	hp.json	Abnormality of vomer bone|Defect of vomer|Abnormality of vomer	http://purl.obolibrary.org/obo/HP_0410000		
GO:0006493	biolink:BiologicalProcess	protein O-linked glycosylation	A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.	RESID:AA0212|RESID:AA0157|RESID:AA0155|RESID:AA0154|RESID:AA0153	hp.json	protein amino acid O-linked glycosylation	http://purl.obolibrary.org/obo/GO_0006493		
CL:0005009	biolink:Cell	renal principal cell	A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the cells apical membrane is regulated by aldosterone and vasopressin. In mammals these cells are located in the renal collecting ducts.		hp.json		http://purl.obolibrary.org/obo/CL_0005009		
CL:0005000	biolink:Cell	spinal cord interneuron	A CNS interneuron located in the spinal cord.		hp.json		http://purl.obolibrary.org/obo/CL_0005000		
HP:0040179	biolink:PhenotypicFeature	Decreased level of platelet-activating factor		UMLS:C4073144	hp.json	Decreased level of PAF	http://purl.obolibrary.org/obo/HP_0040179		
GO:0031424	biolink:BiologicalProcess	keratinization	The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.		hp.json		http://purl.obolibrary.org/obo/GO_0031424		
HP:0410027	biolink:PhenotypicFeature	Alveolar bone loss around teeth	A decrease in the amount of alveolar bone around the root of a tooth.		hp.json	Bone loss around teeth	http://purl.obolibrary.org/obo/HP_0410027		
HP:0410026	biolink:PhenotypicFeature	Abnormal periodontium morphology	Any abnormality of the periodontium.		hp.json	Abnormality of the periodontium	http://purl.obolibrary.org/obo/HP_0410026		
HP:0040170	biolink:PhenotypicFeature	Abnormality of hair growth		UMLS:C4073136	hp.json		http://purl.obolibrary.org/obo/HP_0040170		
HP:0410028	biolink:PhenotypicFeature	Recurrent oral herpes	Recurrent episodes of oral herpes, typically characterized by blisters or ulcers on the gums, lips and/or tongue caused by herpes virus.		hp.json	Recurrent herpes labialis	http://purl.obolibrary.org/obo/HP_0410028		
HP:0040173	biolink:PhenotypicFeature	Abnormality of the tongue muscle		UMLS:C4073139	hp.json	Abnormality of the tongue muscle|Abnormality of lingual muscle	http://purl.obolibrary.org/obo/HP_0040173		
HP:0040174	biolink:PhenotypicFeature	Abnormality of extrinsic muscle of tongue		UMLS:C4073140	hp.json	Abnormality of extrinsic lingual muscle	http://purl.obolibrary.org/obo/HP_0040174		
HP:0040171	biolink:PhenotypicFeature	Decreased serum testosterone concentration		UMLS:C4073137|UMLS:C1295654|SNOMEDCT_US:131078003	hp.json	Decreased serum testosterone level|Low serum testosterone level|Decreased serum testosterone levels|Low serum testosterone levels|Decreased testosterone	http://purl.obolibrary.org/obo/HP_0040171		
HP:0040172	biolink:PhenotypicFeature	Abnormality of occipitofrontalis muscle		UMLS:C4073138	hp.json		http://purl.obolibrary.org/obo/HP_0040172		
HP:0040177	biolink:PhenotypicFeature	Abnormal level of platelet-activating factor		UMLS:C4073142	hp.json	Abnormal level of PAF	http://purl.obolibrary.org/obo/HP_0040177		
HP:0410023	biolink:PhenotypicFeature	Abnormal distribution of cell junction proteins in buccal mucosal cells	An anomalous amount or location of cell junction proteins such as plakoglobin or Cx43.		hp.json		http://purl.obolibrary.org/obo/HP_0410023		
HP:0410022	biolink:PhenotypicFeature	Vaginal fish odor	A fish odor in the vaginal area, that is characteristic of bacterial vaginosis (BV), and is due to trimethylamine (TMA).		hp.json	Vaginal fish odour|Vaginal fish odor	http://purl.obolibrary.org/obo/HP_0410022		
HP:0040178	biolink:PhenotypicFeature	Increased level of platelet-activating factor		UMLS:C4073143	hp.json	Increased level of PAF	http://purl.obolibrary.org/obo/HP_0040178		
HP:0410021	biolink:PhenotypicFeature	Musty odor	Pungent body odor.		hp.json	Musty odor|Musty odour	http://purl.obolibrary.org/obo/HP_0410021		
HP:0040175	biolink:PhenotypicFeature	Platelet-activating factor acetylhydrolase deficiency	Reduced level of platelet-activating factor acetylhydrolase.	UMLS:C3280315|MSH:C566640	hp.json		http://purl.obolibrary.org/obo/HP_0040175		
HP:0410020	biolink:PhenotypicFeature	Fish odor	Body odor characterized by an offensive body odor and the smell of rotting fish due to the excessive excretion of trimethylamine (TMA) in the urine, sweat, and breath of affected individuals.		hp.json	Fishy body odour|Fishy odour|Fishy body odor|Fish odour|Fishy odor	http://purl.obolibrary.org/obo/HP_0410020		
HP:0040176	biolink:PhenotypicFeature	Abnormal circulating phospholipid concentration	Any deviation from the normal concentration of a phospholipid in the blood circulation.	UMLS:C4073141	hp.json	Abnormal level of phospholipids	http://purl.obolibrary.org/obo/HP_0040176		
HP:0410016	biolink:PhenotypicFeature	Abnormality of cranial ganglion	An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system of the cranium.	UMLS:C4073195	hp.json		http://purl.obolibrary.org/obo/HP_0410016		
HP:0410015	biolink:PhenotypicFeature	Abnormality of ganglion of peripheral nervous system	An abnormality of nerve cell cluster or a group of nerve cell bodies located in the peripheral autonomic nervous system.	UMLS:C4073194	hp.json		http://purl.obolibrary.org/obo/HP_0410015		
HP:0410014	biolink:PhenotypicFeature	Abnormality of ganglion	An abnormality of nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system.	UMLS:C4073193	hp.json		http://purl.obolibrary.org/obo/HP_0410014		
HP:0410013	biolink:PhenotypicFeature	Abnormality of the submandibular region	Any abnormality of the submandibular region, the region between the mandible and the hyoid bone contains the submandibular and sublingual glands, suprahyoid muscles, submandibular ganglion, and lingual artery.	UMLS:C4073192	hp.json		http://purl.obolibrary.org/obo/HP_0410013		
HP:0040180	biolink:PhenotypicFeature	obsolete Hyperkeratosis pilaris			hp.json		http://purl.obolibrary.org/obo/HP_0040180		
HP:0040181	biolink:PhenotypicFeature	Chapped lip	Cracking, fissuring, and peeling of the skin of the lips.	SNOMEDCT_US:402294001|SNOMEDCT_US:16459000|UMLS:C0263449|SNOMEDCT_US:238751002|SNOMEDCT_US:248182008|MSH:D019557|UMLS:C0424489	hp.json	Chapped lip|Perioral dermatitis|Common cheilitis|Chapped lips|Dry lips|Cheilitis simplex	http://purl.obolibrary.org/obo/HP_0040181		
HP:0410019	biolink:PhenotypicFeature	Epigastric pain	Pain that is localized to the region of the upper abdomen immediately below the ribs.		hp.json	Epigastrium pain	http://purl.obolibrary.org/obo/HP_0410019		
HP:0410018	biolink:PhenotypicFeature	Recurrent ear infections	Increased susceptibility to ear infections, as manifested by recurrent episodes of ear infections.		hp.json	Recurrent ear infections|Frequent ear infections	http://purl.obolibrary.org/obo/HP_0410018		
HP:0410017	biolink:PhenotypicFeature	Otitis externa	Inflammation or infection of the external auditory canal (EAC), the auricle, or both.		hp.json	Swimmer's ear	http://purl.obolibrary.org/obo/HP_0410017		
GO:0031410	biolink:CellularComponent	cytoplasmic vesicle	A vesicle found in the cytoplasm of a cell.	NIF_Subcellular:sao180601769	hp.json	cytoplasmic, membrane-bounded vesicle|cytoplasmic membrane bounded vesicle|cytoplasmic membrane-enclosed vesicle	http://purl.obolibrary.org/obo/GO_0031410		goslim_candida|goslim_agr|goslim_yeast|goslim_generic|goslim_aspergillus|goslim_chembl|goslim_mouse
HP:0040184	biolink:PhenotypicFeature	Oral bleeding		MSH:D006472|UMLS:C0029163|SNOMEDCT_US:22490002	hp.json	Oral haemorrhage|Oral hemorrhage|Oral bleeding	http://purl.obolibrary.org/obo/HP_0040184		
HP:0040185	biolink:PhenotypicFeature	Macrothrombocytopenia		UMLS:C2751260	hp.json	Macrothrombozytopenia	http://purl.obolibrary.org/obo/HP_0040185		
HP:0040182	biolink:PhenotypicFeature	Inappropriate sinus tachycardia	Inappropriate sinus tachycardia is a nonparoxysmal tachyarrhythmia characterized by an increased resting heart rate (HR) and/or an exaggerated HR response to minimal exertion or a change in body posture. HR is constantly above the physiological range with no appropriate relation to metabolic or physiological demands.	UMLS:C1881170|SNOMEDCT_US:425582007	hp.json		http://purl.obolibrary.org/obo/HP_0040182		
HP:0040183	biolink:PhenotypicFeature	Encopresis		UMLS:C2945606|SNOMEDCT_US:302690004	hp.json	Stool soiling|Stool holding	http://purl.obolibrary.org/obo/HP_0040183		
HP:0410012	biolink:PhenotypicFeature	Abnormal mouth floor morphology	Any abnormality of the mouth floor.	UMLS:C4073191	hp.json	Abnormality of the mouth floor|Abnormality of the floor of mouth	http://purl.obolibrary.org/obo/HP_0410012		
HP:0040188	biolink:PhenotypicFeature	Osteochondrosis	Abnormal growth ossification centers in children. Initially a degeneration/ necrosis followed by regeneration or recalcification.	MSH:D055034|SNOMEDCT_US:19579005|UMLS:C0029429	hp.json		http://purl.obolibrary.org/obo/HP_0040188		
HP:0040189	biolink:PhenotypicFeature	Scaling skin	Refers to the loss of the outer layer of the epidermis in large, scale-like flakes.	SNOMEDCT_US:14411002|SNOMEDCT_US:271767006|UMLS:C0237849	hp.json	Scaly skin|Desquamation|flaking skin|peeling skin|Scaling skin	http://purl.obolibrary.org/obo/HP_0040189		
HP:0410011	biolink:PhenotypicFeature	Abnormality of masticatory muscle	Any abnormality of the masticatory muscle.	UMLS:C4073190	hp.json	Abnormality of muscles of mastication	http://purl.obolibrary.org/obo/HP_0410011		
HP:0040186	biolink:PhenotypicFeature	Maculopapular exanthema	A skin rash that is characterized by diffuse cutaneous erythema with areas of skin elevation. It may evolve to vesicles or papules as part of a more severe clinical entity. Different degrees of angioedema with involvement of subcutaneous tissue may also appear.	UMLS:C0423791|SNOMEDCT_US:47725002|SNOMEDCT_US:247471006	hp.json		http://purl.obolibrary.org/obo/HP_0040186		
HP:0410010	biolink:PhenotypicFeature	Abnormality of somatic nerve plexus	Any abnormality of the somatic nerve plexus.	UMLS:C4073189	hp.json		http://purl.obolibrary.org/obo/HP_0410010		
HP:0040187	biolink:PhenotypicFeature	Neonatal sepsis	Systemic inflammatory response to infection in newborn babies.	SNOMEDCT_US:206376005|MSH:D000071074|UMLS:C0456103	hp.json		http://purl.obolibrary.org/obo/HP_0040187		
CHEBI:20067	biolink:ChemicalSubstance	3-hydroxybutyric acid	A straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics.	PMID:17579249|PMID:17190852|PMID:10855969|LIPID_MAPS_instance:LMFA01050005|PMID:6061736|Wikipedia:3-hydroxybutyrate|HMDB:HMDB0000357|Beilstein:773861|CAS:300-85-6|Reaxys:773861	hp.json	3-hydroxybutanoic acid|beta-Hydroxybuttersaeure|(1)-3-Hydroxybutyric acid|DL-beta-Hydroxybutyric acid|beta-hydroxy-n-butyric acid|BHBA|beta-Hydroxy-n-butyric acid|3-OH-butyric acid|beta-hydroxybutyric acid|3 HBA|beta-hydroxybutanoic acid|3-Hydroxybuttersaeure	http://purl.obolibrary.org/obo/CHEBI_20067		3_STAR
GO:0006449	biolink:BiologicalProcess	regulation of translational termination	Any process that modulates the frequency, rate or extent of translational termination.		hp.json		http://purl.obolibrary.org/obo/GO_0006449		
GO:0031406	biolink:MolecularActivity	carboxylic acid binding	Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-).		hp.json		http://purl.obolibrary.org/obo/GO_0031406		goslim_pir
GO:0006448	biolink:BiologicalProcess	regulation of translational elongation	Any process that modulates the frequency, rate, extent or accuracy of translational elongation.		hp.json		http://purl.obolibrary.org/obo/GO_0006448		
GO:0031401	biolink:BiologicalProcess	positive regulation of protein modification process	Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.		hp.json	up regulation of protein modification|stimulation of protein modification|up-regulation of protein modification|activation of protein modification|upregulation of protein modification	http://purl.obolibrary.org/obo/GO_0031401		
GO:0006446	biolink:BiologicalProcess	regulation of translational initiation	Any process that modulates the frequency, rate or extent of translational initiation.		hp.json		http://purl.obolibrary.org/obo/GO_0006446		
HP:0410049	biolink:PhenotypicFeature	Abnormal radial ray morphology			hp.json	Abnormality of radial ray|Radial ray deformity|Radial ray abnormality|Radial ray anomaly|Deformity of radial ray	http://purl.obolibrary.org/obo/HP_0410049		
HP:0040191	biolink:PhenotypicFeature	Rectus femoris muscle atrophy		UMLS:C2083352	hp.json	Atrophy of the rectus femoris muscles	http://purl.obolibrary.org/obo/HP_0040191		
HP:0040192	biolink:PhenotypicFeature	APUdoma	An endocrine tumor arising from an APUD cell.	SNOMEDCT_US:253008000|MSH:D001079|SNOMEDCT_US:74926005|UMLS:C0003650	hp.json	amine precursor uptake and decarboxylation tumours	http://purl.obolibrary.org/obo/HP_0040192		
HP:0040190	biolink:PhenotypicFeature	White scaling skin		UMLS:C4073146	hp.json	White scaly skin|White scaling skin	http://purl.obolibrary.org/obo/HP_0040190		
HP:0040195	biolink:PhenotypicFeature	Decreased head circumference	An abnormally reduced head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. Microcephaly is defined as a head circumference (HC) that is great than two standard deviations below the mean of age- and gender-matched population based samples. Severe microcephaly is defined with an HC that is three standard deviations below the mean.	UMLS:C0424688|SNOMEDCT_US:271611007	hp.json	Decreased head circumference	http://purl.obolibrary.org/obo/HP_0040195		
GO:0031400	biolink:BiologicalProcess	negative regulation of protein modification process	Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.		hp.json	downregulation of protein modification|down regulation of protein modification|inhibition of protein modification|down-regulation of protein modification	http://purl.obolibrary.org/obo/GO_0031400		
HP:0040196	biolink:PhenotypicFeature	Mild microcephaly	Decreased occipito-frontal (head) circumference (OFC). For the microcephaly OFC must be between -3 SD and -2 SD compared to appropriate, age matched, normal standards (i.e. -3 SD <= OFC < -2 SD).	UMLS:C1836806	hp.json		http://purl.obolibrary.org/obo/HP_0040196		
HP:0040193	biolink:PhenotypicFeature	obsolete Pinealoblastoma			hp.json		http://purl.obolibrary.org/obo/HP_0040193		
HP:0040194	biolink:PhenotypicFeature	Increased head circumference	An abnormally increased head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart.	UMLS:C4083076	hp.json	Increased head circumference	http://purl.obolibrary.org/obo/HP_0040194		
HP:0040199	biolink:PhenotypicFeature	obsolete Flat midface			hp.json		http://purl.obolibrary.org/obo/HP_0040199		
HP:0040197	biolink:PhenotypicFeature	Encephalomalacia	Encephalomalacia is the softening or loss of brain tissue after cerebral infarction, cerebral ischemia, infection, craniocerebral trauma, or other injury.	MSH:D004678|SNOMEDCT_US:58762006|UMLS:C0014068	hp.json	Cerebral softening	http://purl.obolibrary.org/obo/HP_0040197		
HP:0410043	biolink:PhenotypicFeature	Abnormal neural tube morphology	Any structural anomaly of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord).	Fyler:4339	hp.json		http://purl.obolibrary.org/obo/HP_0410043		
HP:0410042	biolink:PhenotypicFeature	Abnormal liver morphology	Any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage.	Fyler:4447	hp.json		http://purl.obolibrary.org/obo/HP_0410042		
HP:0040198	biolink:PhenotypicFeature	Non-medullary thyroid carcinoma		MSH:C536915|UMLS:C3501843	hp.json	Nonmedullary thyroid carcinoma|Thyroid cancer, nonmedullary	http://purl.obolibrary.org/obo/HP_0040198		
HP:0410035	biolink:PhenotypicFeature	Abnormal T cell activation	Any abnormality in the activation of T cells, i.e. the change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.		hp.json	Abnormal T-lymphocyte activation|Abnormal T lymphocyte activation|Abnormal T-cell activation	http://purl.obolibrary.org/obo/HP_0410035		
HP:0410030	biolink:PhenotypicFeature	Cleft lip	A gap in the lip or lips.		hp.json	Cleft lip|Cleft of the lip	http://purl.obolibrary.org/obo/HP_0410030		
HP:0410034	biolink:PhenotypicFeature	Bilateral alveolar cleft of maxilla	Nonmidline alveolar cleft of the maxilla.		hp.json		http://purl.obolibrary.org/obo/HP_0410034		
HP:0410033	biolink:PhenotypicFeature	Unilateral alveolar cleft of maxilla	One sided alveolar cleft of the maxilla.		hp.json		http://purl.obolibrary.org/obo/HP_0410033		
HP:0410032	biolink:PhenotypicFeature	obsolete Cleft of uvula			hp.json		http://purl.obolibrary.org/obo/HP_0410032		
HP:0410031	biolink:PhenotypicFeature	Submucous cleft of soft and hard palate	Soft and hard-palate submucous clefts are characterized by bony defects in the midline of the soft and hard palate that are covered by the lining (ie mucous membrane) of the roof of the mouth.		hp.json		http://purl.obolibrary.org/obo/HP_0410031		
HP:0040137	biolink:PhenotypicFeature	Comedonal acne	A type of acne in which open and closed comedones comprise the majority of the lesions, with substantially fewer papules and pustules.	UMLS:C4022418	hp.json	Comedogenic acne	http://purl.obolibrary.org/obo/HP_0040137		
HP:0040138	biolink:PhenotypicFeature	Mucinous histiocytosis	Multiple subcutaneous non-fragile and skin-coloured papules characterized by interstitial infiltrate of spindle and epithelioid histiocytes, and mucin. There are well circumscribed aggregates of epithelioid histiocytes and mucin in the upper and middle dermis,with the histiocytes arranged between collagen bundles and separated from the epidermis by a Grenz zone.	UMLS:C0334126|SNOMEDCT_US:87412005	hp.json	Histiocytosis, mucinous	http://purl.obolibrary.org/obo/HP_0040138		
HP:0040135	biolink:PhenotypicFeature	Abnormal transferrin saturation	Any abnormality in the serum transferrin saturation, which is calculated by dividing the serum iron level by total iron-binding capacity.	UMLS:C4022419	hp.json		http://purl.obolibrary.org/obo/HP_0040135		
HP:0003191	biolink:PhenotypicFeature	Cleft ala nasi	The presence of a notch in the margin of the ala nasi.	UMLS:C1844537	hp.json	Alar clefts|Notched nasal alae|Nostril coloboma|Cleft nasal alae|Cleft nostril|Ala nasi, cleft	http://purl.obolibrary.org/obo/HP_0003191		
HP:0410070	biolink:PhenotypicFeature	Increased level of ribitol in urine	An increase in the level of ribitol in the urine. Ribotol is a crystalline pentose alcohol (C5H12O5) and is a metabolic end product formed by the reduction of ribose.		hp.json		http://purl.obolibrary.org/obo/HP_0410070		
UBERON:5103631	biolink:AnatomicalEntity	pedal digit 1 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 1 plus the associated metapodial element.		hp.json	pedal digit I digitopodial skeleton|pedal digit 1 skeleton|pedal digit 1	http://purl.obolibrary.org/obo/UBERON_5103631		
HP:0040139	biolink:PhenotypicFeature	Lipogranulomatosis	Yellow nodules of lipoid material are deposited in the skin and mucosae. This gives rise to granulomatous reactions.	SNOMEDCT_US:189099001|SNOMEDCT_US:416439000|SNOMEDCT_US:36279001|UMLS:C1704214	hp.json		http://purl.obolibrary.org/obo/HP_0040139		
HP:0410069	biolink:PhenotypicFeature	Increased level of propylene glycol in blood	An increase in the level of propylene glycol in the blood.		hp.json	Increased level of propane-1,2-diol in blood	http://purl.obolibrary.org/obo/HP_0410069		
HP:0003189	biolink:PhenotypicFeature	Long nose	Distance from nasion to subnasale more than two standard deviations above the mean, or alternatively, an apparently increased length from the nasal root to the nasal base.	UMLS:C1839798	hp.json	Increased nasal height|Increased nasal length|Nasal elongation|Long nose|Increased height of nose|Increased length of nose|Elongated nose	http://purl.obolibrary.org/obo/HP_0003189		
HP:0410068	biolink:PhenotypicFeature	Increased level of L-glutamic acid in blood	An increase in the level of L-glutamic acid in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0410068		
HP:0003184	biolink:PhenotypicFeature	Decreased hip abduction	Reduced ability to move the femur outward to the side.	UMLS:C1836589	hp.json	Limited hip abduction	http://purl.obolibrary.org/obo/HP_0003184		
UBERON:5103623	biolink:AnatomicalEntity	manual digit 3 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 3 plus the associated metapodial element.		hp.json	manual digit 3|manual digit 3 skeleton|manual digit III digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5103623		
HP:0410063	biolink:PhenotypicFeature	Increased level of galactonate in red blood cells	An increase in the level of galactonate in the red blood cells.		hp.json	Increased level of galactonate in erythrocytes|Increased level of galactonate in RBCs	http://purl.obolibrary.org/obo/HP_0410063		
UBERON:5103624	biolink:AnatomicalEntity	manual digit 4 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 4 plus the associated metapodial element.		hp.json	manual digit 4|manual digit 4 skeleton|manual digit IV digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5103624		
HP:0410062	biolink:PhenotypicFeature	Increased level of galactitol in urine	An increase in the level of galactitol in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410062		
HP:0003183	biolink:PhenotypicFeature	Wide pubic symphysis	Abnormally increased width of the pubic symphysis is the midline cartilaginous joint uniting the superior rami of the left and right pubic bones.	UMLS:C1857190	hp.json	Wide symphysis of pubis	http://purl.obolibrary.org/obo/HP_0003183		hposlim_core
HP:0040130	biolink:PhenotypicFeature	Abnormal serum iron concentration		UMLS:C0235760	hp.json		http://purl.obolibrary.org/obo/HP_0040130		
HP:0410061	biolink:PhenotypicFeature	Increased level of galactitol in plasma	An increase in the level of galactitol in the plasma.		hp.json		http://purl.obolibrary.org/obo/HP_0410061		
HP:0003182	biolink:PhenotypicFeature	Shallow acetabular fossae		UMLS:C1860796|UMLS:C1854910	hp.json	Shallow acetabular fossa|Shallow acetabulum|Shallow acetabula|Shallow acetabulae	http://purl.obolibrary.org/obo/HP_0003182		
UBERON:5103622	biolink:AnatomicalEntity	manual digit 2 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 2 plus the associated metapodial element.		hp.json	manual digit 2 skeleton|manual digit 2|manual digit II digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5103622		
HP:0410060	biolink:PhenotypicFeature	Decreased level of D-mannose in urine	A decrease in the level of D-mannose in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410060		
HP:0040133	biolink:PhenotypicFeature	Abnormal circulating ferritin concentration	A deviation from the normal circulating concentration of ferritin. Ferritin concentration can be measured in serum or plasma.	UMLS:C0853228	hp.json	Abnormal serum ferritin|Abnormal plasma ferritin	http://purl.obolibrary.org/obo/HP_0040133		
HP:0410067	biolink:PhenotypicFeature	Increased level of L-fucose in urine	An increase in the level of L-fucose in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410067		
HP:0410066	biolink:PhenotypicFeature	Increased level of hippuric acid in urine	An increase in the level of hippuric acid in the urine.		hp.json	Increased level of N-benzoylglycine in urine	http://purl.obolibrary.org/obo/HP_0410066		
HP:0040134	biolink:PhenotypicFeature	Abnormal hepatic iron concentration		UMLS:C4022420	hp.json	Abnormal liver iron level|Abnormal liver iron concentration	http://purl.obolibrary.org/obo/HP_0040134		
HP:0003187	biolink:PhenotypicFeature	Breast hypoplasia	Underdevelopment of the breast.	SNOMEDCT_US:8915006|UMLS:C0266013	hp.json	Underdeveloped breasts	http://purl.obolibrary.org/obo/HP_0003187		
HP:0040131	biolink:PhenotypicFeature	Abnormal motor nerve conduction velocity		UMLS:C4021031	hp.json		http://purl.obolibrary.org/obo/HP_0040131		
HP:0410065	biolink:PhenotypicFeature	Increased level of hippuric acid in blood	An increase in the level of hippuric acid in the blood.		hp.json	Increased level of N-benzoylglycine in blood	http://purl.obolibrary.org/obo/HP_0410065		
UBERON:5103625	biolink:AnatomicalEntity	manual digit 5 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 5 plus the associated metapodial element.		hp.json	manual digit 5|manual digit 5 skeleton|manual digit V digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5103625		
HP:0003186	biolink:PhenotypicFeature	Inverted nipples	The presence of nipples that instead of pointing outward are retracted inwards.	SNOMEDCT_US:82231009|UMLS:C0269269	hp.json	Invaginated nipples|Inverted nipples	http://purl.obolibrary.org/obo/HP_0003186		
HP:0410064	biolink:PhenotypicFeature	Increased level of galactitol in red blood cells	An increase in the level of galactitol in the red blood cells.		hp.json	Increased level of galactitol in erythrocytes	http://purl.obolibrary.org/obo/HP_0410064		
HP:0003185	biolink:PhenotypicFeature	Short greater sciatic notch	The sacroiliac joint in the bony pelvis connects the sacrum and the ilium of the pelvis, which are joined by strong ligaments. The notch is located directly superior to the joint. This term refers to a reduction in the height of the notch.	UMLS:C1866689	hp.json	Short sacroiliac notch|Shortened sacroiliac notches|Small sacroiliac notch	http://purl.obolibrary.org/obo/HP_0003185		
HP:0040132	biolink:PhenotypicFeature	Abnormal sensory nerve conduction velocity		UMLS:C4022421	hp.json		http://purl.obolibrary.org/obo/HP_0040132		
HP:0040148	biolink:PhenotypicFeature	Cortical myoclonus	Cortical myoclonus mainly affects the distal upper limbs and face, which reflects the largest cortical representations of these body areas. It is often focal, but may be multifocal, bilateral or generalized, as a consequence of intracortical and transcallosal spreading of abnormal activity. It typically occurs on voluntary action and may affect speech and gait. Cortical myoclonic jerks are stimulus sensitive, typically to touch, but sensitivity to visual stimuli is also described. Most patients with cortical myoclonus have both positive myoclonus and NM, occurring either independently or together as a complex of the two kinds of myoclonus. If cortical myoclonus is prolonged and lasts for hours, days or weeks, it is called epilepsia partials continua and is considered to be a rare form of focal epileptic status. Focal cortical myoclonus almost always points to an underlining lesion of the sensori-motor cortex, which produces hyperexcitability (e.g. vascular, inflammatory or neoplastic).	UMLS:C3698239|SNOMEDCT_US:698835006	hp.json		http://purl.obolibrary.org/obo/HP_0040148		
HP:0040149	biolink:PhenotypicFeature	Woolly scalp hair	The presence of woolly hair on the scalp. The term woolly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter.	UMLS:C4280293|UMLS:C4280292|UMLS:C4015203|UMLS:C4280291	hp.json	Nappy scalp hair texture|Kinky scalp hair texture|Afro-textured scalp hair|Wooly scalp hair	http://purl.obolibrary.org/obo/HP_0040149		
HP:0040146	biolink:PhenotypicFeature	D-2-hydroxyglutaric acidemia		UMLS:C4022415	hp.json		http://purl.obolibrary.org/obo/HP_0040146		
HP:0040147	biolink:PhenotypicFeature	L-2-hydroxyglutaric acidemia		UMLS:C3888081	hp.json		http://purl.obolibrary.org/obo/HP_0040147		
PR:P21183	biolink:Protein	interleukin-5 receptor subunit alpha (mouse)	An interleukin-5 receptor subunit alpha that is encoded in the genome of mouse.	UniProtKB:P21183	hp.json	IL-5R-alpha (mouse)|Il5ra|Il5r|CD125 (mouse)|IL-5 receptor subunit alpha (mouse)|mIL5RA|IL-5RA (mouse)|IL-5R subunit alpha (mouse)	http://purl.obolibrary.org/obo/PR_P21183		
MPATH:194	biolink:NamedThing	immune mediated disease	Tissue response to inappropriate immune/inflammatory process.		hp.json		http://purl.obolibrary.org/obo/MPATH_194		
MPATH:196	biolink:NamedThing	dermatitis	Inflammation of the skin.		hp.json		http://purl.obolibrary.org/obo/MPATH_196		
HP:0410059	biolink:PhenotypicFeature	Increased level of D-threitol in urine	An increase in the level of D-threitol in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410059		
MPATH:198	biolink:NamedThing	immune mediated hemolytic anaemia	An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction.		hp.json		http://purl.obolibrary.org/obo/MPATH_198		
HP:0410058	biolink:PhenotypicFeature	Increased level of D-threitol in CSF	An increase in the level of D-threitol in the cerebrospinal fluid.		hp.json	Increased level of D-threitol in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0410058		
MPATH:197	biolink:NamedThing	glomerulonephritis	Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment.		hp.json		http://purl.obolibrary.org/obo/MPATH_197		
HP:0410057	biolink:PhenotypicFeature	Increased level of D-threitol in plasma	An increase in the level of D-threitol in the plasma.		hp.json		http://purl.obolibrary.org/obo/HP_0410057		
HP:0410052	biolink:PhenotypicFeature	Increased level of allantoin in serum	An increase in the level of allantoin in the serum.		hp.json		http://purl.obolibrary.org/obo/HP_0410052		
UBERON:5103634	biolink:AnatomicalEntity	pedal digit 4 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 4 plus the associated metapodial element.		hp.json	pedal digit 4 skeleton|pedal digit 4|pedal digit IV digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5103634		
HP:0040140	biolink:PhenotypicFeature	Degeneration of the striatum		UMLS:C4022417	hp.json		http://purl.obolibrary.org/obo/HP_0040140		
HP:0040141	biolink:PhenotypicFeature	Tardive dyskinesia		UMLS:C0686347|MSH:D000071057	hp.json		http://purl.obolibrary.org/obo/HP_0040141		
UBERON:5103635	biolink:AnatomicalEntity	pedal digit 5 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 5 plus the associated metapodial element.		hp.json	pedal digit V digitopodial skeleton|pedal digit 5 skeleton|pedal digit 5	http://purl.obolibrary.org/obo/UBERON_5103635		
HP:0003194	biolink:PhenotypicFeature	Short nasal bridge	Decreased superior-inferior length of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose.	UMLS:C1854689	hp.json	Short bridge of nose|Decreased length of nasal bridge|Short nasal bridge|Decreased length of bridge of nose	http://purl.obolibrary.org/obo/HP_0003194		
HP:0410051	biolink:PhenotypicFeature	Increased level of 3-hydroxy-3-methylglutaric acid in urine	An increase in the level of 3-hydroxy-3-methylglutaric acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410051		
HP:0003193	biolink:PhenotypicFeature	Allergic rhinitis	It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea.	MSH:D065631|UMLS:C2607914|SNOMEDCT_US:61582004|UMLS:C0847614	hp.json	Nasal allergies|Hayfever|Hay fever	http://purl.obolibrary.org/obo/HP_0003193		
UBERON:5103632	biolink:AnatomicalEntity	pedal digit 2 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 2 plus the associated metapodial element.		hp.json	pedal digit 2 skeleton|pedal digit II digitopodial skeleton|pedal digit 2	http://purl.obolibrary.org/obo/UBERON_5103632		
HP:0410050	biolink:PhenotypicFeature	Decreased level of 1,5 anhydroglucitol in serum	A decrease in the level of 1,5 anhydroglucitol in the serum. 1,5-Anhydrosorbitol is a validated marker of short-term glycemic control. This substance is derived mainly from food, is well absorbed in the intestine, and is distributed to all organs and tissues.		hp.json	Decreased level of 1,5-anhydroglucitol in serum|Decreased level of 1,5-AG in serum|Decreased level of 1,5-anhydro-D-glucitol in serum	http://purl.obolibrary.org/obo/HP_0410050		
UBERON:5103633	biolink:AnatomicalEntity	pedal digit 3 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit 3 plus the associated metapodial element.		hp.json	pedal digit III digitopodial skeleton|pedal digit 3 skeleton|pedal digit 3	http://purl.obolibrary.org/obo/UBERON_5103633		
HP:0040144	biolink:PhenotypicFeature	L-2-hydroxyglutaric aciduria	An increase in the level of L-2-hydroxyglutaric acid in the urine.	SNOMEDCT_US:237961001|UMLS:C1855995	hp.json		http://purl.obolibrary.org/obo/HP_0040144		
HP:0410056	biolink:PhenotypicFeature	Decreased level of erythritol in CSF	A decrease in the level of erythritol in the cerebrospinal fluid.		hp.json	Decreased level of erythritol in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0410056		
HP:0003199	biolink:PhenotypicFeature	Decreased muscle mass		UMLS:C1837108	hp.json	Decreased muscle mass	http://purl.obolibrary.org/obo/HP_0003199		
HP:0003198	biolink:PhenotypicFeature	Myopathy	A disorder of muscle unrelated to impairment of innervation or neuromuscular junction.	UMLS:C0026848|SNOMEDCT_US:129565002|MSH:D009135	hp.json	Muscle tissue disease|Myopathic changes	http://purl.obolibrary.org/obo/HP_0003198		
HP:0410055	biolink:PhenotypicFeature	Decreased level of erythritol in urine	A decrease in the level of erythritol in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410055		
HP:0040145	biolink:PhenotypicFeature	Dicarboxylic acidemia		UMLS:C4022416	hp.json		http://purl.obolibrary.org/obo/HP_0040145		
HP:0040142	biolink:PhenotypicFeature	Reduced 5-oxoprolinase level	Decreased level of the reaction 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate.	SNOMEDCT_US:26132002|UMLS:C0268525|MSH:C535322	hp.json	5-oxoprolinase deficiency	http://purl.obolibrary.org/obo/HP_0040142		
HP:0410054	biolink:PhenotypicFeature	Decreased circulating GABA concentration	A decrease in the level of GABA in the serum.		hp.json	Decreased circulating gamma-aminobutyric acid concentration|Decreased level of gamma-aminobutyric acid in serum	http://purl.obolibrary.org/obo/HP_0410054		
HP:0003196	biolink:PhenotypicFeature	Short nose	Distance from nasion to subnasale more than two standard deviations below the mean, or alternatively, an apparently decreased length from the nasal root to the nasal tip.	UMLS:C0426414|UMLS:C1854114|SNOMEDCT_US:249310005	hp.json	Hypoplastic nose|Decreased length of nose|Shortened nose|Short nose|Small nose|Nasal hypoplasia	http://purl.obolibrary.org/obo/HP_0003196		hposlim_core
HP:0410053	biolink:PhenotypicFeature	Elevated circulating gamma-aminobutyric acid concentration	An increase in the level of Gamma-aminobutyric acid (GABA) in the blood circulation.		hp.json	Increased level of GABA in serum|Increased circulating GABA concentration|Increased level of gamma-aminobutyric acid in serum	http://purl.obolibrary.org/obo/HP_0410053		
HP:0040143	biolink:PhenotypicFeature	Dystopic os odontoideum	Os odontoideum is classified into two anatomic types (orthotopic and dystopic). Os odontoideum is defined as an ossicle that consists of smooth and separate caudal portions of the odontoid process. With orthotopic os odontoideum, the ossicle moves with the anterior arch of the atlas, while the dystopic type consists of an ossicle near the basion, or one that is fused with the clivus	UMLS:C3552843	hp.json		http://purl.obolibrary.org/obo/HP_0040143		
HP:0040159	biolink:PhenotypicFeature	Abnormal spaced incisors		UMLS:C4022410	hp.json	Abnormality of spacing of incisors|Abnormality of spacing of front teeth|Abnormal spaced incisors	http://purl.obolibrary.org/obo/HP_0040159		
HP:0040157	biolink:PhenotypicFeature	Abnormal intermamillary distance		UMLS:C4022412	hp.json		http://purl.obolibrary.org/obo/HP_0040157		
HP:0040158	biolink:PhenotypicFeature	Short intermamillary distance		UMLS:C4022411	hp.json		http://purl.obolibrary.org/obo/HP_0040158		
MPATH:184	biolink:NamedThing	sclerosis	Any pathological thickening or hardening of a tissue.		hp.json	Induration	http://purl.obolibrary.org/obo/MPATH_184		
HP:0003168	biolink:PhenotypicFeature	Dibasicaminoaciduria	An increased level of a dibasic amino acid in the urine. Dibasic amino acids are usually refered to simply as basic aminoacids because they contain basic side chains at neutral pH. These are arginine (Arg), lysine (Lys), and histidine (His).	UMLS:C4025643	hp.json		http://purl.obolibrary.org/obo/HP_0003168		
HP:0003167	biolink:PhenotypicFeature	Carnosinuria	An increased concentration of carnosine in the urine.	UMLS:C3495558|SNOMEDCT_US:410051001	hp.json	High urine carnosine levels	http://purl.obolibrary.org/obo/HP_0003167		
MPATH:188	biolink:NamedThing	immunopathological process	Inappropriate or aberrant activation or suppression of the immune or inflammatory response.		hp.json		http://purl.obolibrary.org/obo/MPATH_188		
HP:0003162	biolink:PhenotypicFeature	Fasting hypoglycemia		SNOMEDCT_US:6974005|UMLS:C0271708|MSH:D007003	hp.json	Low blood sugar when fasting	http://purl.obolibrary.org/obo/HP_0003162		
HP:0040151	biolink:PhenotypicFeature	Epiblepharon of lower lid		UMLS:C1851583|MSH:C565051	hp.json		http://purl.obolibrary.org/obo/HP_0040151		
HP:0003161	biolink:PhenotypicFeature	4-Hydroxyphenylpyruvic aciduria	Increased concentration of pyruvic acid in the urine.	UMLS:C1848678	hp.json	Hydroxyphenylpyruvic aciduria	http://purl.obolibrary.org/obo/HP_0003161		
HP:0003160	biolink:PhenotypicFeature	Abnormal isoelectric focusing of serum transferrin	Glycosylated transferrin concentrations can be measured in serum as a marker of N-linked glycosylation fidelity. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II. These terms are retained for historical reasons but for new annotations the precise glycosylation defect should be recorded.	UMLS:C2749688	hp.json	Abnormal transferrin isoelectric focusing|Abnormal isoelectric focusing of transferrin	http://purl.obolibrary.org/obo/HP_0003160		
HP:0040150	biolink:PhenotypicFeature	Epiblepharon of upper lid		UMLS:C1851582|MSH:C565051	hp.json		http://purl.obolibrary.org/obo/HP_0040150		
PR:000007749	biolink:Protein	glucose-6-phosphate 1-dehydrogenase	A glucose-6-phosphate dehydrogenase that is a translation product of the human G6PD gene or a 1:1 ortholog thereof.		hp.json	G6PD|G6pd-1|G6pdx|glucose-6-phosphate 1-dehydrogenase X	http://purl.obolibrary.org/obo/PR_000007749		
HP:0003166	biolink:PhenotypicFeature	Increased urinary taurine	Increased concentration of taurine in the urine.	UMLS:C3806447	hp.json	Increased urinary taurine	http://purl.obolibrary.org/obo/HP_0003166		
HP:0040155	biolink:PhenotypicFeature	Elevated urinary 3-hydroxybutyric acid	An increased amount of 3-hydroxybutyric acid in the urine.	UMLS:C4022414	hp.json		http://purl.obolibrary.org/obo/HP_0040155		
HP:0003165	biolink:PhenotypicFeature	Elevated circulating parathyroid hormone level	An abnormal increased concentration of parathyroid hormone.	UMLS:C0857973	hp.json	Elevated serum parathyroid hormone level|Elevated serum pth|Elevated serum parathyroid hormone|Elevated circulating PTH level|Increased serum parathyroid hormone	http://purl.obolibrary.org/obo/HP_0003165		
HP:0040156	biolink:PhenotypicFeature	Elevated urinary carboxylic acid	An increased amount of carboxylic acid in the urine.	UMLS:C4022413	hp.json		http://purl.obolibrary.org/obo/HP_0040156		
HP:0003164	biolink:PhenotypicFeature	Hypothalamic gonadotropin-releasing hormone deficiency		UMLS:C4025644	hp.json	Hypothalamic GNRH deficiency	http://purl.obolibrary.org/obo/HP_0003164		
HP:0003163	biolink:PhenotypicFeature	Elevated urinary delta-aminolevulinic acid	An increased concentration of 5-aminolevulinic acid (CHEBI:17549) in the urine.	UMLS:C1848702	hp.json	Elevated urinary delta-aminolevulinic acid	http://purl.obolibrary.org/obo/HP_0003163		
HP:0040154	biolink:PhenotypicFeature	Acne inversa	A chronic skin condition involving the inflammation of the apocrine sweat glands, forming pimple-like bumps known as abscesses.	MSH:D017497|UMLS:C0162836|SNOMEDCT_US:59393003	hp.json	Hidradenitis suppurativa|Pyoderma fistulans significa|Verneuil's disease|Smoker's boils	http://purl.obolibrary.org/obo/HP_0040154		
HP:0040168	biolink:PhenotypicFeature	obsolete Focal seizures, afebril			hp.json		http://purl.obolibrary.org/obo/HP_0040168		
HP:0040169	biolink:PhenotypicFeature	Loose anagen hair		UMLS:C3554793	hp.json		http://purl.obolibrary.org/obo/HP_0040169		
CHEBI:71666	biolink:ChemicalSubstance	gamma-amino acid anion	An amino-acid anion in which the amino group is situated gamma- to the carboxylate group.		hp.json	gamma-amino acid anions	http://purl.obolibrary.org/obo/CHEBI_71666		3_STAR
HP:0003180	biolink:PhenotypicFeature	Flat acetabular roof	Flattening of the superior part of the acetabulum, which is a cup-shaped cavity at the base of the hipbone into which the ball-shaped head of the femur fits. The acetabular roof thereby appears horizontal rather than arched, as it normally does.	UMLS:C1837485	hp.json	Flat acetabular roofs|Horizontal acetabular roof|Flattened acetabular roof|Horizontal acetabulae|Horizontal acetabular roofs	http://purl.obolibrary.org/obo/HP_0003180		hposlim_core
GO:0043401	biolink:BiologicalProcess	steroid hormone mediated signaling pathway	The series of molecular signals mediated by a steroid hormone binding to a receptor.		hp.json	steroid hormone mediated signalling	http://purl.obolibrary.org/obo/GO_0043401		
HP:0003179	biolink:PhenotypicFeature	Protrusio acetabuli	Intrapelvic bulging of the medial acetabular wall.	SNOMEDCT_US:59606006|UMLS:C0409495	hp.json	Protrusio acetabulae|Abnormally indented hip sockets	http://purl.obolibrary.org/obo/HP_0003179		hposlim_core
MPATH:176	biolink:NamedThing	connective tissue replacement	Replacement of connective tissue by fibro-fatty deposits and scar tissue.		hp.json		http://purl.obolibrary.org/obo/MPATH_176		
MPATH:175	biolink:NamedThing	healing and repair process	The process, normal or abnormal, of damage repair or wound closure.		hp.json		http://purl.obolibrary.org/obo/MPATH_175		
HP:0410074	biolink:PhenotypicFeature	Increased level of xylitol in urine	An increase in the level of xylitol in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410074		
HP:0003173	biolink:PhenotypicFeature	Hypoplastic pubic bone	Underdevelopment of the pubis, which together with the ilium and the ischium, is one of the three bones that make up the hip bone.	UMLS:C1865030	hp.json	Hypoplastic pubic bones|Hypoplastic pubis	http://purl.obolibrary.org/obo/HP_0003173		
HP:0040162	biolink:PhenotypicFeature	Orthokeratosis	Formation of an anuclear keratin layer	SNOMEDCT_US:708474007|UMLS:C1843359	hp.json		http://purl.obolibrary.org/obo/HP_0040162		
HP:0410073	biolink:PhenotypicFeature	Increased level of ribose in CSF	An increase in the level of ribose in the cerebrospinal fluid.		hp.json	Increased level of ribose in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0410073		
HP:0040163	biolink:PhenotypicFeature	Abnormal pelvis bone morphology		UMLS:C4073132	hp.json	Abnormal shape of pelvis bone	http://purl.obolibrary.org/obo/HP_0040163		
HP:0003172	biolink:PhenotypicFeature	Abnormality of the pubic bone	An anomaly of the the pubic bone, i.e., of the ventral and anterior of the three principal components (publis, ilium, ischium) of the hip bone.	UMLS:C4021738	hp.json	Abnormality of the pubic bone|Abnormality of the pubis|Abnormality of the pubic bones	http://purl.obolibrary.org/obo/HP_0003172		hposlim_core
HP:0410072	biolink:PhenotypicFeature	Increased level of ribose in urine	An increase in the level of ribose in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0410072		
HP:0040160	biolink:PhenotypicFeature	Generalized osteoporosis		UMLS:C0029456|UMLS:C3805887|MSH:D010024|SNOMEDCT_US:64859006	hp.json	Generalised osteoporosis|Generalised osteoporosis with pathologic fractures|Generalized osteoporosis with pathologic fractures	http://purl.obolibrary.org/obo/HP_0040160		
HP:0003170	biolink:PhenotypicFeature	Abnormal acetabulum morphology	An abnormality of the acetabulum, i.e., the Acetabular part of hip bone, which together with the head of the femur forms the hip joint.	UMLS:C4021739	hp.json	Acetabular abnormality|Abnormality of the acetabulum|Abnormality of the hipbone socket	http://purl.obolibrary.org/obo/HP_0003170		hposlim_core
HP:0410071	biolink:PhenotypicFeature	Increased level of ribitol in CSF	An increase in the level of ribitol in the cerebral spinal fluid.		hp.json	Increased level of ribitol in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0410071		
HP:0040161	biolink:PhenotypicFeature	Localized osteoporosis		UMLS:C1398367	hp.json	Localised osteoporosis	http://purl.obolibrary.org/obo/HP_0040161		
HP:0040166	biolink:PhenotypicFeature	obsolete Abnormality of the periosteum			hp.json		http://purl.obolibrary.org/obo/HP_0040166		
HP:0003177	biolink:PhenotypicFeature	Squared iliac bones	A shift from the normally round (convex) appearance of the iliac wing towards a square-like appearance.	UMLS:C1838186	hp.json	Square iliac bones|Squaring of iliac bones	http://purl.obolibrary.org/obo/HP_0003177		
HP:0040167	biolink:PhenotypicFeature	Facial papilloma		SNOMEDCT_US:240533004|UMLS:C0343643	hp.json	Facial verruca|Facial wart	http://purl.obolibrary.org/obo/HP_0040167		
HP:0040164	biolink:PhenotypicFeature	Lipomas of eyelids	Fatty tumors on the eyelids.	UMLS:C4073133	hp.json	Fatty tumors on the eyelids|Fatty tumours on the eyelids	http://purl.obolibrary.org/obo/HP_0040164		
HP:0003175	biolink:PhenotypicFeature	Hypoplastic ischia	Underdevelopment of the ischium, which forms the lower and back part of the hip bone.	UMLS:C1859447	hp.json	Hypoplastic ischial bones|Hypoplastic ischium|Hypoplastic ischii	http://purl.obolibrary.org/obo/HP_0003175		hposlim_core
HP:0003174	biolink:PhenotypicFeature	Abnormality of the ischium	An anomaly of the ischium, which forms the lower and back part of the hip bone.	SNOMEDCT_US:93008005|UMLS:C0685661	hp.json	Abnormality of the ischial bones|Anomaly of the ischium	http://purl.obolibrary.org/obo/HP_0003174		
HP:0410075	biolink:PhenotypicFeature	Increased level of xylitol in CSF	An increase in the level of xylitol in the cerebrospinal fluid.		hp.json	Increased level of xylitol in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0410075		
HP:0040165	biolink:PhenotypicFeature	Periostitis	Inflammation of the periosteum	MSH:D010522|SNOMEDCT_US:41910004|UMLS:C0031111	hp.json	Periostalgia	http://purl.obolibrary.org/obo/HP_0040165		
CHEBI:177917	biolink:ChemicalSubstance	phenolic steroid		KEGG:C02453|MetaCyc:PHENOLIC-STEROID	hp.json	a phenolic steroid	http://purl.obolibrary.org/obo/CHEBI_177917		2_STAR
HP:0030770	biolink:PhenotypicFeature	Craniorachischisis	A neural tube defect in which both the brain and spinal cord remain open to varying degrees.	MSH:D009436|SNOMEDCT_US:32219008|UMLS:C0152426	hp.json		http://purl.obolibrary.org/obo/HP_0030770		
HP:0030771	biolink:PhenotypicFeature	Mallet finger	Mallet finger refers to a condition in which the end joint of a finger bends but will not straighten by itself. In this situation, the joint can be pushed straight but will not hold that position on its own.	SNOMEDCT_US:64298006|UMLS:C0158473	hp.json		http://purl.obolibrary.org/obo/HP_0030771		
GO:0043412	biolink:BiologicalProcess	macromolecule modification	The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.		hp.json		http://purl.obolibrary.org/obo/GO_0043412		goslim_pir
HP:0030772	biolink:PhenotypicFeature	Proximal femoral focal deficiency	Proximal femoral focal deficiency is a deformity manifested by hypoplasia of a variable portion of the femur with shortening of the entire limb.	SNOMEDCT_US:205211001|UMLS:C0431996	hp.json		http://purl.obolibrary.org/obo/HP_0030772		
HP:0030773	biolink:PhenotypicFeature	Internuclear ophthalmoplegia	An abnormality of conjugate lateral gaze in which the affected eye shows impairment of adduction. The pathognomonic clinical sign of internuclear ophthalmoplegia is an impaired adduction while testing horizontal saccades on the side of the lesion in the ipsilateral medial longitudinal fascicule.	MSH:D015835|UMLS:C0152134|SNOMEDCT_US:49823009	hp.json		http://purl.obolibrary.org/obo/HP_0030773		
HP:0030778	biolink:PhenotypicFeature	Modic type III vertebral endplate changes	An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1 and T2-weighted sequences. Modic type III signals are thought to correspond to subchondral sclerosis seen on plain radiographs.	UMLS:C4280775	hp.json	Modic type 3 vertebral endplate changes	http://purl.obolibrary.org/obo/HP_0030778		
HP:0030779	biolink:PhenotypicFeature	Ethmocephaly	Ethmocephaly is the rarest form of holoprosencephaly, which occurs due to an incomplete cleavage of the forebrain. Clinically, the disease presents with a proboscis, hypotelorism, microphthalmos and malformed ears.	UMLS:C0266680|SNOMEDCT_US:55709000	hp.json		http://purl.obolibrary.org/obo/HP_0030779		
OBO:uberon/core#transitively_proximally_connected_to	biolink:NamedThing	transitively proximally connected to	.		hp.json		http://purl.obolibrary.org/obo/uberon/core#transitively_proximally_connected_to		
HP:0030774	biolink:PhenotypicFeature	Mitochondrial swelling	The mitochondrial matrix refers to the substance occupying the space enclosed by the inner membrane of a mitochondrion, which contains enzymes, DNA, granules, and inclusions of protein crystals, glycogen, and lipid. Mitochondrial swelling refers to an increase in size of the mitochondrial matrix. This phenomenon is thought to be related to a permeabilized inner membrane that originates a large swelling in the mitochondrial matrix. Mitochondrial swelling may distend the outer membrane until it ruptures.	MSH:D008933|UMLS:C0026244|SNOMEDCT_US:125429001	hp.json		http://purl.obolibrary.org/obo/HP_0030774		
GO:0043413	biolink:BiologicalProcess	macromolecule glycosylation	The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.		hp.json		http://purl.obolibrary.org/obo/GO_0043413		
HP:0030775	biolink:PhenotypicFeature	Modic type vertebral endplate changes	An abnormal magnetic resonance tomography signal from a vertebral endplate according to a widely used classification published by Dr. Michael Modic.	UMLS:C4280778	hp.json		http://purl.obolibrary.org/obo/HP_0030775		
HP:0030776	biolink:PhenotypicFeature	Modic type I vertebral endplate changes	An abnormal magnetic resonance tomography signal from a vertebral endplate with a low signal on T1-weighted sequences and high signal on T2-weighted sequences. Modic type I changes are thought to represent bone marrow edema and inflammation.	UMLS:C4280777	hp.json	Modic type 1 vertebral endplate changes	http://purl.obolibrary.org/obo/HP_0030776		
HP:0030777	biolink:PhenotypicFeature	Modic type II vertebral endplate changes	An abnormal magnetic resonance tomography signal from a vertebral endplate with a high signal on T1-weighted sequences and high- or isointense signal on T2 sequences. Modic type II signals are thought to indicate fatty replacement in the bone marrow.	UMLS:C4280776	hp.json	Modic type 2 vertebral endplate changes	http://purl.obolibrary.org/obo/HP_0030777		
CHEBI:71671	biolink:ChemicalSubstance	aldonate(1-)	A carbohydrate acid anion obtained by deprotonation of any aldonic acid. Major structure at pH 7.3 of aldonate compounds.		hp.json	aldonates	http://purl.obolibrary.org/obo/CHEBI_71671		3_STAR
HP:0040104	biolink:PhenotypicFeature	Osseous stenosis of the external auditory canal		UMLS:C4022437	hp.json		http://purl.obolibrary.org/obo/HP_0040104		
HP:0040102	biolink:PhenotypicFeature	Osseous atresia of the external auditory canal		UMLS:C4022439	hp.json		http://purl.obolibrary.org/obo/HP_0040102		
HP:0040103	biolink:PhenotypicFeature	Cutaneous stenosis of the external auditory canal		UMLS:C4022438	hp.json		http://purl.obolibrary.org/obo/HP_0040103		
HP:0040108	biolink:PhenotypicFeature	Morphological abnormality of the anterior semicircular canal		UMLS:C4022435	hp.json		http://purl.obolibrary.org/obo/HP_0040108		
HP:0040109	biolink:PhenotypicFeature	Morphological abnormality of the utricle		UMLS:C4022434	hp.json		http://purl.obolibrary.org/obo/HP_0040109		
HP:0040106	biolink:PhenotypicFeature	Morphological abnormality of the lateral semicircular canal		UMLS:C4021034	hp.json	Morphological abnormality of the horizontal semicircular canal	http://purl.obolibrary.org/obo/HP_0040106		
HP:0040107	biolink:PhenotypicFeature	Morphological abnormality of the posterior semicircular canal		UMLS:C4022436	hp.json		http://purl.obolibrary.org/obo/HP_0040107		
HP:0030781	biolink:PhenotypicFeature	Increased circulating free fatty acid level	A higher than normal levels of the fatty acids which can occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues.	UMLS:C4280773	hp.json		http://purl.obolibrary.org/obo/HP_0030781		
HP:0030782	biolink:PhenotypicFeature	Abnormal circulating interleukin concentration	An abnormal amount of any of the interleukins, a class of cytokines, in the circulation.	UMLS:C4280772	hp.json	Abnormal serum IL level|Abnormal serum interleukin level	http://purl.obolibrary.org/obo/HP_0030782		
HP:0030783	biolink:PhenotypicFeature	Increased circulating interleukin 6 concentration	An increased concentration of interleukin-6 in the blood circulation.	UMLS:C4280771	hp.json	Increased serum IL-6|Increased serum interleukin-6	http://purl.obolibrary.org/obo/HP_0030783		
HP:0030784	biolink:PhenotypicFeature	Anomic aphasia	An inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name.	MSH:D000849|UMLS:C0003113|SNOMEDCT_US:10325006	hp.json	Amnestic aphasia|Nominal aphasia|Amnesic aphasia|Word-finding difficulty|Anomia	http://purl.obolibrary.org/obo/HP_0030784		
HP:0030780	biolink:PhenotypicFeature	Abnormality of the protein C anticoagulant pathway	An anomaly of the protein C anticoagulant pathway, which serves as a major system for controlling thrombosis, limiting inflammatory responses, and potentially decreasing endothelial cell apoptosis in response to inflammatory cytokines and ischemia. A natural anticoagulant system denoted the protein C pathway exerts its anticoagulant effect by regulating the activity of FVIIIa and FVa. The vitamin K-dependent protein C is the key component of the pathway. Activated protein C (APC) cleaves and inhibits coagulation cofactors FVIIIa and FVa, which result in downregulation of the activity of the coagulation system. The endothelial protein C receptor stimulates the T-TM-mediated activation of protein C on the endothelial cell surface. The two cofactors, protein S and the intact form of FV, enhance the anticoagulant activity of APC.	UMLS:C4280774	hp.json		http://purl.obolibrary.org/obo/HP_0030780		
HP:0030789	biolink:PhenotypicFeature	Excessive cerumen	An increased quantity of earwax.	UMLS:C1382811	hp.json		http://purl.obolibrary.org/obo/HP_0030789		
MPATH:154	biolink:NamedThing	hyperkeratosis	Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis.		hp.json	cornification|hyperparakeratosis|hyperorthokeratosis	http://purl.obolibrary.org/obo/MPATH_154		
HP:0030785	biolink:PhenotypicFeature	Mediastinal cystic lymphangioma	A lymphangioma (congenital malformation consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures) located within the mediastinum, i.e., the central compartment of the thoracic cavity that is surrounded by loose connective tissue. Mediastinal lymphangioma is a slow growing mass with benign features, and accounts for 1% of all mediastinal tumors.	UMLS:C4280770	hp.json	Thoracic cystic lymphangioma|Intrathoracic cystic hygroma	http://purl.obolibrary.org/obo/HP_0030785		
MPATH:156	biolink:NamedThing	parakeratosis	Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum.		hp.json		http://purl.obolibrary.org/obo/MPATH_156		
HP:0030786	biolink:PhenotypicFeature	Photopsia	Perceived flashes of light.	SNOMEDCT_US:56170001|UMLS:C0085635	hp.json		http://purl.obolibrary.org/obo/HP_0030786		
HP:0030787	biolink:PhenotypicFeature	Cerumen abnormality	Any anomaly of the cerumen (ear wax), the yellowish waxy substance secreted in the ear canal.	UMLS:C4280769	hp.json		http://purl.obolibrary.org/obo/HP_0030787		
HP:0030788	biolink:PhenotypicFeature	Impacted cerumen	Blockage of the external auditory canal by a buildup of earwax.	UMLS:C0021092|SNOMEDCT_US:18070006	hp.json		http://purl.obolibrary.org/obo/HP_0030788		
GO:0031497	biolink:BiologicalProcess	chromatin assembly	The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus.		hp.json	establishment of chromatin architecture|chromatin maintenance	http://purl.obolibrary.org/obo/GO_0031497		
HP:0040100	biolink:PhenotypicFeature	Abnormality of the vestibular window		UMLS:C4021035	hp.json	Abnormality of the oval window	http://purl.obolibrary.org/obo/HP_0040100		
HP:0040101	biolink:PhenotypicFeature	Cutaneous atresia of the external auditory canal		UMLS:C4022440	hp.json		http://purl.obolibrary.org/obo/HP_0040101		
HP:0040115	biolink:PhenotypicFeature	Abnormal Eustachian tube morphology	A structural anomaly of the Eustachian tube (ET). The ET is a biomechanical valve between the nasopharynx and the middle ear. Physiologically, it controls the passive adaptation of the middle ear air pressure to the ambient air pressure primarily via direct muscular actions of the soft palate. In the closed state it protects the middle ear. Inadequate function of the ET causes middle ear ventilation disorders.	UMLS:C0262475|SNOMEDCT_US:204250005	hp.json	Abnormality of the Eustachian tube	http://purl.obolibrary.org/obo/HP_0040115		
HP:0040116	biolink:PhenotypicFeature	Aplasia of the Eustachian tube		UMLS:C0266616|SNOMEDCT_US:75231006	hp.json	Absent eustachian tube	http://purl.obolibrary.org/obo/HP_0040116		
HP:0040113	biolink:PhenotypicFeature	Old-aged sensorineural hearing impairment		SNOMEDCT_US:49526009|UMLS:C0033074|MSH:D011304	hp.json	Presbycusis	http://purl.obolibrary.org/obo/HP_0040113		
HP:0040114	biolink:PhenotypicFeature	Absence of the reflex of the tensor tympani muscle		UMLS:C4022430	hp.json		http://purl.obolibrary.org/obo/HP_0040114		
HP:0040119	biolink:PhenotypicFeature	Unilateral conductive hearing impairment		UMLS:C4022428	hp.json		http://purl.obolibrary.org/obo/HP_0040119		
HP:0040117	biolink:PhenotypicFeature	Atresia of the Eustachian tube		UMLS:C1388953	hp.json		http://purl.obolibrary.org/obo/HP_0040117		
HP:0040118	biolink:PhenotypicFeature	Stenosis of the Eustachian tube		UMLS:C0271469|SNOMEDCT_US:80101003	hp.json		http://purl.obolibrary.org/obo/HP_0040118		
HP:0030792	biolink:PhenotypicFeature	Jaw neoplasm	A tumor originating in the jaw (mandible or maxilla).	SNOMEDCT_US:126634001|UMLS:C0022364|MSH:D007573	hp.json		http://purl.obolibrary.org/obo/HP_0030792		
HP:0030793	biolink:PhenotypicFeature	Jaw swelling	Abnormal enlargement in the upper jaw (maxilla) or in the lower jaw (mandible).	UMLS:C4280766	hp.json		http://purl.obolibrary.org/obo/HP_0030793		
HP:0030794	biolink:PhenotypicFeature	Abnormal C-peptide level	An anomolous circulating concentration of the connecting (C) peptide, which links the insulin A and B chains in proinsulin, providing thereby a means to promote their efficient folding and assembly in the endoplasmic reticulum during insulin biosynthesis. After cleavage of proinsulin, C-peptide is stored with insulin in the soluble phase of the secretory granules and is subsequently released in equimolar amounts with insulin, providing a useful independent indicator of insulin secretion.	UMLS:C4280765	hp.json	Abnormal C peptide level	http://purl.obolibrary.org/obo/HP_0030794		
GO:0043434	biolink:BiologicalProcess	response to peptide hormone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.		hp.json	response to polypeptide hormone stimulus|response to peptide hormone stimulus	http://purl.obolibrary.org/obo/GO_0043434		
HP:0030795	biolink:PhenotypicFeature	Reduced C-peptide level	A decreased concentration of C-peptide in the circulation. Since C-peptide is secreted in equimolar amounts to insulin, this feature correlates with reduced insulin secretion.	UMLS:C4280764	hp.json	Reduced C peptide level	http://purl.obolibrary.org/obo/HP_0030795		
HP:0030790	biolink:PhenotypicFeature	Abnormal cerumen color	An anomolous earwax color. Earwax (cerumen) is usually light to dark brown or orange in color.	UMLS:C4280768	hp.json	Abnormal cerumen colour|Abnormal cerumen pigmentation	http://purl.obolibrary.org/obo/HP_0030790		
HP:0030791	biolink:PhenotypicFeature	Abnormal jaw morphology	A structural anomaly of the jaw, the bony structure of the mouth that consists of the mandible and the maxilla.	UMLS:C4280767	hp.json		http://purl.obolibrary.org/obo/HP_0030791		
HP:0030796	biolink:PhenotypicFeature	Increased C-peptide level	An elevated concentration of C-peptide in the circulation. Since C-peptide is secreted in equimolar amounts to insulin, this feature correlates with increased insulin secretion.	UMLS:C4280763	hp.json	Increased C peptide level	http://purl.obolibrary.org/obo/HP_0030796		
GO:0043436	biolink:BiologicalProcess	oxoacid metabolic process	The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).		hp.json	keto acid metabolic process|oxo acid metabolic process|ketoacid metabolism|oxoacid metabolism|ketoacid metabolic process|oxo acid metabolism|keto acid metabolism	http://purl.obolibrary.org/obo/GO_0043436		
HP:0030797	biolink:PhenotypicFeature	Reduced volume of central subdivision of bed nucleus of stria terminalis	A diminished volume of the central part of the bed nucleus of the stria terminalis.	UMLS:C4280762	hp.json		http://purl.obolibrary.org/obo/HP_0030797		
HP:0030798	biolink:PhenotypicFeature	Abnormality of the bed nucleus of stria terminalis	The stria terminalis is a slender, compact fiber bundle that connects the amygdala (amygdaloid body) with the hypothalamus and other basal forebrain regions. The bed nucleus of the stria terminalis is a limbic forebrain structure that receives heavy projections from, among other areas, the basolateral amygdala, and projects in turn to hypothalamic and brainstem target areas that mediate many of the autonomic and behavioral responses to aversive or threatening stimuli. This term refers to an anomaly of the bed nucleus.	UMLS:C4280761	hp.json		http://purl.obolibrary.org/obo/HP_0030798		
HP:0030799	biolink:PhenotypicFeature	Scaphocephaly	Scaphocephaly is a subtype of dolichocephaly where the anterior and posterior aspects of the cranial vault are pointed (boat-shaped). Scaphocephaly is caused by a precocious fusion of sagittal suture without other associated synostosis.	UMLS:C0265534|SNOMEDCT_US:4191007|MSH:D003398	hp.json		http://purl.obolibrary.org/obo/HP_0030799		
MPATH:149	biolink:NamedThing	squamous hyperplasia	Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia).		hp.json	squamous cell hyperplasia|epidermal hyperplasia.	http://purl.obolibrary.org/obo/MPATH_149		
HP:0040111	biolink:PhenotypicFeature	obsolete Bilateral external ear deformity			hp.json		http://purl.obolibrary.org/obo/HP_0040111		
HP:0040112	biolink:PhenotypicFeature	Abnormal number of tubercles		UMLS:C4022431	hp.json		http://purl.obolibrary.org/obo/HP_0040112		
CHEBI:138366	biolink:ChemicalSubstance	bile acids	Any member of a group of hydroxy steroids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration, while in lower vertebrates, some bile acids, known as allo-bile acids, have 5alpha-configuration.		hp.json		http://purl.obolibrary.org/obo/CHEBI_138366		3_STAR
HP:0040110	biolink:PhenotypicFeature	Morphological abnormality of the saccule		UMLS:C4022433	hp.json		http://purl.obolibrary.org/obo/HP_0040110		
HP:0040126	biolink:PhenotypicFeature	Abnormal vitamin B12 level	A deviation from the normal concentration of cobalamin (vitamin B12) in the blood. Vitamin B12 is one of the eight B vitamins.	UMLS:C4021032	hp.json	Abnormal serum cobalamin level	http://purl.obolibrary.org/obo/HP_0040126		
HP:0040127	biolink:PhenotypicFeature	Abnormal sweat homeostasis	An abnormality of the composition of sweat or the levels of its components.	UMLS:C4022423	hp.json		http://purl.obolibrary.org/obo/HP_0040127		
HP:0040124	biolink:PhenotypicFeature	obsolete Patent tuba eustachii			hp.json		http://purl.obolibrary.org/obo/HP_0040124		
HP:0040128	biolink:PhenotypicFeature	Abnormal sweat electrolytes		UMLS:C4022422	hp.json		http://purl.obolibrary.org/obo/HP_0040128		
HP:0040129	biolink:PhenotypicFeature	Abnormal nerve conduction velocity		UMLS:C1866772	hp.json	Abnormal nerve conduction|Nerve conduction abnormalities|Abnormal nerve conduction velocities	http://purl.obolibrary.org/obo/HP_0040129		
HP:0040122	biolink:PhenotypicFeature	Impairment of the the acoustic reflex		UMLS:C4022425	hp.json		http://purl.obolibrary.org/obo/HP_0040122		
HP:0040123	biolink:PhenotypicFeature	Impairment of the reflex of the tensor tympani muscle		UMLS:C4022424	hp.json		http://purl.obolibrary.org/obo/HP_0040123		
HP:0040120	biolink:PhenotypicFeature	Abnormality of the reflex of the tensor tympani muscle		UMLS:C4022427	hp.json		http://purl.obolibrary.org/obo/HP_0040120		
HP:0040121	biolink:PhenotypicFeature	Abnormality of the acoustic reflex	An abnormality in the reflexive contraction of the middle-ear muscles in response to sound stimulation.	UMLS:C4022426	hp.json	Abnormal auditory reflex|Abnormality of stapedial reflex|Abnormal middle-ear-muscles (MEM) reflex	http://purl.obolibrary.org/obo/HP_0040121		
UBERON:0015032	biolink:AnatomicalEntity	pedal digit 2 phalanx endochondral element	A pedal digit 2 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit 2 phalanx element|pedal digit 2 phalanx skeletal element|pedal digit II phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015032		
UBERON:0015031	biolink:AnatomicalEntity	pedal digit 1 phalanx endochondral element	A pedal digit 1 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit 1 phalanx element|pedal digit 1 phalanx skeletal element|pedal digit I phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015031		
UBERON:0015034	biolink:AnatomicalEntity	pedal digit 4 phalanx endochondral element	A pedal digit 4 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit 4 phalanx element|pedal digit 4 phalanx skeletal element|pedal digit IV phalanx endochondral element	http://purl.obolibrary.org/obo/UBERON_0015034		
UBERON:0015033	biolink:AnatomicalEntity	pedal digit 3 phalanx endochondral element	A pedal digit 3 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit 3 phalanx element|pedal digit III phalanx endochondral element|pedal digit 3 phalanx skeletal element	http://purl.obolibrary.org/obo/UBERON_0015033		
UBERON:0017692	biolink:AnatomicalEntity	internal surface of cranial base	Internal (endosteal) surface of the base of skull.	FMA:53128	hp.json	basis cranii interna	http://purl.obolibrary.org/obo/UBERON_0017692		pheno_slim
UBERON:0015030	biolink:AnatomicalEntity	pedal digit phalanx endochondral element	A pedal digit phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit phalanx element|pedal digit phalanx skeletal element	http://purl.obolibrary.org/obo/UBERON_0015030		
UBERON:0017690	biolink:AnatomicalEntity	internal surface of frontal bone		FMA:52856	hp.json	facies interna ossis frontalis|facies interna (os frontale)	http://purl.obolibrary.org/obo/UBERON_0017690		pheno_slim
UBERON:0015039	biolink:AnatomicalEntity	pedal digit 3 metatarsal endochondral element	A pedal digit 3 metatarsal bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit 3 metatarsal element|pedal digit 3 metatarsal skeletal element|pedal digit III metatarsal endochondral element	http://purl.obolibrary.org/obo/UBERON_0015039		
HP:0003109	biolink:PhenotypicFeature	Hyperphosphaturia	An increased excretion of phosphates in the urine.	UMLS:C0948023|SNOMEDCT_US:22450000|UMLS:C0268079	hp.json	High urine phosphate levels|Phosphaturia	http://purl.obolibrary.org/obo/HP_0003109		
UBERON:0015036	biolink:AnatomicalEntity	pedal digit metatarsal endochondral element	A pedal digit metatarsal bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit metatarsal element|pedal digit metatarsal skeletal element	http://purl.obolibrary.org/obo/UBERON_0015036		
UBERON:0015035	biolink:AnatomicalEntity	pedal digit 5 phalanx endochondral element	A pedal digit 5 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit 5 phalanx element|pedal digit V phalanx endochondral element|pedal digit 5 phalanx skeletal element	http://purl.obolibrary.org/obo/UBERON_0015035		
UBERON:0015038	biolink:AnatomicalEntity	pedal digit 2 metatarsal endochondral element	A pedal digit 2 metatarsal bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit 2 metatarsal element|pedal digit II metatarsal endochondral element|pedal digit 2 metatarsal skeletal element	http://purl.obolibrary.org/obo/UBERON_0015038		
UBERON:0015037	biolink:AnatomicalEntity	pedal digit 1 metatarsal endochondral element	A pedal digit 1 metatarsal bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit 1 metatarsal skeletal element|pedal digit I metatarsal endochondral element|pedal digit 1 metatarsal element	http://purl.obolibrary.org/obo/UBERON_0015037		
UBERON:0003054	biolink:AnatomicalEntity	roof plate	A single row of glia at the dorsal midline of the developing neural tube along the entire anterior-posterior axis. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells.	VHOG:0000303|EHDAA:916|TAO:0007058|AAO:0011097|ZFA:0001436|EHDAA2:0001270|TAO:0001436|EMAPA:16168|EMAPA:35361|EHDAA:2891|ZFA:0007058	hp.json	roof plate neural tube region|roofplate|future brain roof plate|alar plate|roof plate neural tube	http://purl.obolibrary.org/obo/UBERON_0003054		uberon_slim|vertebrate_core|pheno_slim
HP:0005767	biolink:PhenotypicFeature	1-2 toe complete cutaneous syndactyly		UMLS:C4025140	hp.json		http://purl.obolibrary.org/obo/HP_0005767		
HP:0005768	biolink:PhenotypicFeature	2-4 toe cutaneous syndactyly	A soft tissue continuity in the anteroposterior axis between the toes 2, 3, and 4.	UMLS:C4021622	hp.json	Soft tissue syndactyly of toes 2, 3, and 4|Webbed second, third and fourth toes|Webbed 2nd, 3rd and 4th toes	http://purl.obolibrary.org/obo/HP_0005768		
UBERON:0003055	biolink:AnatomicalEntity	periderm	A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis.	UMLS:C1518973|TAO:0001185|FMA:295662|XAO:0000029|EHDAA2:0001846|VHOG:0001680|EHDAA:6538|NCIT:C34247|ZFA:0001185	hp.json	epidermis epithelial layer|periderm|epitrichium|EVL|skin periderm|epidermis outer layer	http://purl.obolibrary.org/obo/UBERON_0003055		uberon_slim|pheno_slim
HP:0003103	biolink:PhenotypicFeature	Abnormal cortical bone morphology	An abnormality of compact bone (also known as cortical bone), which forms the dense surface of bones.	UMLS:C4021741	hp.json	Abnormal compact bone morphology|Abnormality of cortical bone	http://purl.obolibrary.org/obo/HP_0003103		
HP:0030735	biolink:PhenotypicFeature	Ureterovesical junction obstruction	Blockage at the level of the bladder and the ureter caused by stenosis of the ureteral valves or failure of a narrow juxtavesical ureteral segment to dilate due to segmented fibrosis or localized absence of muscle.	UMLS:C2609249	hp.json		http://purl.obolibrary.org/obo/HP_0030735		
UBERON:0003052	biolink:AnatomicalEntity	midbrain-hindbrain boundary	The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate.	AAO:0011064|EHDAA2:0004395|XAO:0000016|DMBA:16810|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2076|EHDAA:5789|VHOG:0000649|EMAPA:32857|ZFA:0000042|NCIT:C93172|TAO:0000042	hp.json	isthmus/MHB|isthmo-cerebellar region|mid-hindbrain boundary|isthmic organizer territory|midbrain hindbrain boundary|mid-hindbrain junction|isthmus|MHB	http://purl.obolibrary.org/obo/UBERON_0003052		uberon_slim|vertebrate_core|pheno_slim
HP:0005769	biolink:PhenotypicFeature	Fifth finger distal phalanx clinodactyly	Bending or curvature of the distal phalanx of little finger in the radial direction (i.e., towards the 4th finger).	UMLS:C4025139|UMLS:C4280477	hp.json	Curvature of outermost bone of pinkie finger|Curvature of outermost bone of pinky finger|Curvature of outermost bone of little finger	http://purl.obolibrary.org/obo/HP_0005769		
HP:0030736	biolink:PhenotypicFeature	Sacrococcygeal teratoma	A teratoma arising in the sacro-coccygeal region.	UMLS:C0559459|SNOMEDCT_US:281561000	hp.json		http://purl.obolibrary.org/obo/HP_0030736		
HP:0003102	biolink:PhenotypicFeature	Increased carrying angle	An abnormal increase in the carrying angle, which is the angle he long axis of the extended forearm as it lies lateral to the long axis of the arm.	UMLS:C1855478	hp.json		http://purl.obolibrary.org/obo/HP_0003102		
MPATH:120	biolink:NamedThing	ecchymosis	A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae.		hp.json		http://purl.obolibrary.org/obo/MPATH_120		
HP:0030737	biolink:PhenotypicFeature	Altman type I sacrococcygeal teratoma	A type of sacrococcygeal teratoma that is predominantly external and projects from the sacrococcygeal region and presents with distortion of the buttocks.	UMLS:C4280795	hp.json		http://purl.obolibrary.org/obo/HP_0030737		
HP:0003108	biolink:PhenotypicFeature	Hyperglycinuria	An increased concentration of glycine in the urine.	MSH:C563009|SNOMEDCT_US:236477004|UMLS:C0543541|UMLS:C0341706	hp.json	High urine glycine levels|Glycinuria	http://purl.obolibrary.org/obo/HP_0003108		
HP:0030730	biolink:PhenotypicFeature	Parietal meningocele	A herniation of meninges through a congenital bone defect in the skull in the parietal region.	UMLS:C4280797	hp.json		http://purl.obolibrary.org/obo/HP_0030730		
UBERON:0003050	biolink:AnatomicalEntity	olfactory placode	A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity.	AAO:0011076|EFO:0003420|XAO:0000005|EHDAA:1504|ZFA:0000048|VHOG:0000186|EMAPA:16543|TAO:0000048|FMA:293971|EHDAA2:0001232	hp.json	nasal I placode|olfactory placodes|placoda olfactoria|nasal placode|placoda nasalis	http://purl.obolibrary.org/obo/UBERON_0003050		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0003051	biolink:AnatomicalEntity	ear vesicle	An epithelial sac of invaginated ectoderm formed from the otic placode that gives rise to the structures of the inner ear[MP].	TAO:0000051|VHOG:0001148|NCIT:C34240|EMAPA:16669|FMA:302920|BTO:0002661|XAO:0000006|AAO:0011080|UMLS:C1518678|ZFA:0000051|EHDAA2:0001342	hp.json	otocyst|acoustic vesicle|OV|otic vesicle|auditory vesicle	http://purl.obolibrary.org/obo/UBERON_0003051		vertebrate_core|pheno_slim
HP:0005764	biolink:PhenotypicFeature	Polyarticular arthritis		UMLS:C0162323|MSH:D001168|SNOMEDCT_US:416956002|SNOMEDCT_US:417373000	hp.json		http://purl.obolibrary.org/obo/HP_0005764		
HP:0003107	biolink:PhenotypicFeature	Abnormal circulating cholesterol concentration	Any deviation from the normal concentration of cholesterol in the blood circulation.	UMLS:C4025656	hp.json	Abnormal cholesterol homeostasis|Abnormality of cholesterol metabolism	http://purl.obolibrary.org/obo/HP_0003107		
HP:0030731	biolink:PhenotypicFeature	Carcinoma	A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus).	NCIT:C2916|UMLS:C0007097|SNOMEDCT_US:68453008|MSH:D002277	hp.json		http://purl.obolibrary.org/obo/HP_0030731		
HP:0005765	biolink:PhenotypicFeature	Sacral meningocele		SNOMEDCT_US:95478002|UMLS:C0521556	hp.json		http://purl.obolibrary.org/obo/HP_0005765		
HP:0030732	biolink:PhenotypicFeature	Dysplastic tricuspid valve	A congenital malformation of the tricuspid valve characterized by leaflet deformation.	UMLS:C4255215	hp.json	Tricuspid valve dysplasia	http://purl.obolibrary.org/obo/HP_0030732		
HP:0003106	biolink:PhenotypicFeature	Subperiosteal bone resorption	Loss of bone mass occurring beneath the periosteum (the periosteum is the connective-tissue membrane that surrounds all bones except at the articular surfaces). This process may create a serrated and lace-like appearance in periosteal cortical bone.	UMLS:C1848541	hp.json	Subperiosteal erosions	http://purl.obolibrary.org/obo/HP_0003106		
HP:0005766	biolink:PhenotypicFeature	Disproportionate shortening of the tibia		UMLS:C3806516	hp.json	Disproportionate shortening of the shinbone|Disproportionate shortening of the shankbone|Marked shortening of tibia	http://purl.obolibrary.org/obo/HP_0005766		
MPATH:124	biolink:NamedThing	infarct	An area of necrosis resulting from a sudden cessation of arterial or venous blood supply.		hp.json		http://purl.obolibrary.org/obo/MPATH_124		
HP:0003105	biolink:PhenotypicFeature	Protuberances at ends of long bones	The presence of multiple protuberances (bulges, or knobs) at the ends of the long bones.	UMLS:C1851418	hp.json	Protuberances at ends of long bones	http://purl.obolibrary.org/obo/HP_0003105		
HP:0030733	biolink:PhenotypicFeature	Vesicoallantoic abdominal wall defect	An abdominal wall defected related to a developmental anomaly of the allantois, which is an embryonic structure that develops as a diverticulum off the yolk sac at about 16 days post fertilization. During further development, the allantois becomes incorporated into the body of the embryo, connecting the ventral aspect of the urogenital sinus (which will develop into the upper pole of the urinary bladder) to the external portion of the umbilicus. Upon further development, the lumen of the allantois becomes obliterated and forms a thick fibrous cord called the urachus, which connects the apex of the bladder to the umbilicus. In adults, the urachus is known as the median umbilical ligament. Failure of the allantoic cavity to obliterate can result of one of four conditions: 1) congenital patent urachus (a completely open connection between bladder and umbilicus); 2) vesicourachal diverticulum (a diverticulum off the bladder but not communicating with the umbilicus); umbilical cyst and sinus (not communicating with the bladder); and 4) alternating urachal sinus. An abdominal wall defect can be associated with a urachal cyst.	UMLS:C4280796	hp.json		http://purl.obolibrary.org/obo/HP_0030733		
MPATH:126	biolink:NamedThing	growth and differentiation defect	Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs.		hp.json		http://purl.obolibrary.org/obo/MPATH_126		
HP:0003100	biolink:PhenotypicFeature	Slender long bone	Reduced diameter of a long bone.	UMLS:C1833144	hp.json	Slender, gracile long tubular bones|Long bones slender|Slender long bone|Slender long bones|Thin gracile long bones|Thin long bones|Gracile long bones|Thin, gracile long bones	http://purl.obolibrary.org/obo/HP_0003100		
HP:0030738	biolink:PhenotypicFeature	Altman type II sacrococcygeal teratoma	A type of sacrococcygeal teratoma that is predominantly external but has a large intrapelvic component.	UMLS:C4280794	hp.json		http://purl.obolibrary.org/obo/HP_0030738		
UBERON:0003059	biolink:AnatomicalEntity	presomitic mesoderm	Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.	EFO:0001982|AAO:0011086|ZFA:0000279|EMAPA:16752|XAO:0000057|EMAPA:16189|TAO:0000279|VHOG:0000559	hp.json	unsegmented paraxial mesoderm|PSM|somitogenic mesoderm|segmental plate|unsegmented mesenchyme|somitomeric mesoderm|unsegmented paraxial mesoderm|presumptive somite mesoderm	http://purl.obolibrary.org/obo/UBERON_0003059		pheno_slim|efo_slim
HP:0030739	biolink:PhenotypicFeature	Altman type III sacrococcygeal teratoma	A type of sacrococcygeal teratoma that is predominantly intrapelvic with a small external, buttock mass.	UMLS:C4280793	hp.json		http://purl.obolibrary.org/obo/HP_0030739		
UBERON:0003056	biolink:AnatomicalEntity	pre-chordal neural plate	The portion of neural plate anterior to the mid-hindbrain junction.	TAO:0007016|VHOG:0001200|AAO:0011084|XAO:0000045|ZFA:0007016	hp.json	anterior neural plate	http://purl.obolibrary.org/obo/UBERON_0003056		
UBERON:0003057	biolink:AnatomicalEntity	chordal neural plate	The portion of neural plate posterior to the mid-hindbrain junction.	TAO:0007017|VHOG:0001201|XAO:0000046|ZFA:0007017	hp.json	posterior neural plate	http://purl.obolibrary.org/obo/UBERON_0003057		
UBERON:0015021	biolink:AnatomicalEntity	forelimb endochondral element	A forelimb bone or its cartilage or pre-cartilage precursor.		hp.json	forelimb skeletal element	http://purl.obolibrary.org/obo/UBERON_0015021		
UBERON:0015023	biolink:AnatomicalEntity	phalanx endochondral element	A phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	phalanx element|phalanx skeletal element	http://purl.obolibrary.org/obo/UBERON_0015023		
UBERON:0015022	biolink:AnatomicalEntity	hindlimb endochondral element	A hindlimb bone or its cartilage or pre-cartilage precursor.		hp.json	hindlimb bone skeletal element	http://purl.obolibrary.org/obo/UBERON_0015022		
UBERON:0015029	biolink:AnatomicalEntity	manual digit 5 phalanx endochondral element	A manual digit 5 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit V phalanx endochondral element|manual digit 5 phalanx element|manual digit 5 phalanx skeletal element	http://purl.obolibrary.org/obo/UBERON_0015029		
UBERON:0015028	biolink:AnatomicalEntity	manual digit 4 phalanx endochondral element	A manual digit 4 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit IV phalanx endochondral element|manual digit 4 phalanx skeletal element|manual digit 4 phalanx element	http://purl.obolibrary.org/obo/UBERON_0015028		
HP:0030740	biolink:PhenotypicFeature	Anomalous muscle bundle of the right ventricle	An accessory (not normally present) muscle bundle in the right ventricle which obstructs the right ventricular outflow tract.	UMLS:C4280792	hp.json	Right ventricular anomalous muscle bundle	http://purl.obolibrary.org/obo/HP_0030740		
UBERON:0015025	biolink:AnatomicalEntity	manual digit 1 phalanx endochondral element	A manual digit 1 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit 1 phalanx skeletal element|manual digit I phalanx endochondral element|manual digit 1 phalanx element	http://purl.obolibrary.org/obo/UBERON_0015025		
UBERON:0015024	biolink:AnatomicalEntity	manual digit phalanx endochondral element	A manual digit phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit phalanx skeletal element|manual digit phalanx element	http://purl.obolibrary.org/obo/UBERON_0015024		
UBERON:0015027	biolink:AnatomicalEntity	manual digit 3 phalanx endochondral element	A manual digit 3 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit III phalanx endochondral element|manual digit 3 phalanx skeletal element|manual digit 3 phalanx element	http://purl.obolibrary.org/obo/UBERON_0015027		
UBERON:0015026	biolink:AnatomicalEntity	manual digit 2 phalanx endochondral element	A manual digit 2 phalanx bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit 2 phalanx skeletal element|manual digit II phalanx endochondral element|manual digit 2 phalanx element	http://purl.obolibrary.org/obo/UBERON_0015026		
HP:0030745	biolink:PhenotypicFeature	Dilatation of the ductus arteriosus	Ductus arteriosus aneurysm (DAA) is a saccular dilatation of the ductus arteriosus. DAA can be either congenital or acquired (e.g. as a complication of surgical closure of a patent ductus arteriosus). Although the majority of patients with congenital DAA are asymptomatic and have a benign course, severe complications, such as rupture or thromboembolism, can occur. DAA is likely to emerge in the third trimester from the aortic junction of the DA, extending towards its pulmonary end.	SNOMEDCT_US:233990006|UMLS:C0398357	hp.json	Ductus arteriosus aneurysm|Aneurysm of the ductus arteriosus|Congenital ductus arteriosus aneurysm	http://purl.obolibrary.org/obo/HP_0030745		
UBERON:0003043	biolink:AnatomicalEntity	posterior part of anterior commissure	The major forebrain commissure that connects the two temporal lobes of the cortex.	EMAPA:37410|MBA:908|UMLS:C0175210|BAMS:act|FMA:61964|BIRNLEX:977|BAMS:acp	hp.json	anterior commissure, temporal limb|commissura anterior, crus posterius|anterior commissure temporal limb|anterior commissure pars posterior|commissura anterior, pars posterior|commissura rostralis, pars posterior|anterior commissure, posterior part|temporal limb of anterior commissure|pars posterior commissurae anterioris|pars posterior	http://purl.obolibrary.org/obo/UBERON_0003043		pheno_slim
HP:0003115	biolink:PhenotypicFeature	Abnormal EKG	Abnormal rhythm of the heart.	SNOMEDCT_US:102594003|UMLS:C0522055	hp.json	Abnormal EKG|EKG abnormality|Abnormal electrocardiogram|Abnormal ECG	http://purl.obolibrary.org/obo/HP_0003115		
HP:0030746	biolink:PhenotypicFeature	Intraventricular hemorrhage	Bleeding into the ventricles of the brain.	UMLS:C0240059|SNOMEDCT_US:23276006	hp.json	Intraventricular haemorrhage	http://purl.obolibrary.org/obo/HP_0030746		
HP:0003114	biolink:PhenotypicFeature	obsolete Abnormal cardiological findings			hp.json		http://purl.obolibrary.org/obo/HP_0003114		
UBERON:0003041	biolink:AnatomicalEntity	trigeminal nerve fibers	A nerve fiber that is part of a trigeminal nerve.	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=607|UMLS:C0175452|FMA:72501|BIRNLEX:974|BAMS:5nf	hp.json	trigeminal nerve fibers|fibrae nervi trigemini|central part of trigeminal nerve|trigeminal nerve tract	http://purl.obolibrary.org/obo/UBERON_0003041		
HP:0030747	biolink:PhenotypicFeature	Preterm intraventricular hemorrhage	Intraventricular hemorrhage that occurs in a premature infant.	UMLS:C4280789	hp.json	Preterm intraventricular haemorrhage	http://purl.obolibrary.org/obo/HP_0030747		
HP:0003113	biolink:PhenotypicFeature	Hypochloremia	An abnormally decreased chloride concentration in the blood.	SNOMEDCT_US:10399008|UMLS:C0085680|UMLS:C0595901	hp.json	Low blood chloride levels	http://purl.obolibrary.org/obo/HP_0003113		
HP:0003112	biolink:PhenotypicFeature	Abnormal circulating amino acid concentration	The presence of an abnormal decrease or increase of one or more amino acids in the blood circulation.	UMLS:C4025653	hp.json	Abnormality of serum amino acid levels|Abnormality of serum amino acid level	http://purl.obolibrary.org/obo/HP_0003112		
PR:P08101	biolink:Protein	low affinity immunoglobulin gamma Fc region receptor II (mouse)	A low affinity immunoglobulin gamma Fc region receptor II that is encoded in the genome of mouse.	UniProtKB:P08101	hp.json	Fc gamma receptor IIB (mouse)|lymphocyte antigen 17 (mouse)|Fc-gamma RII (mouse)|IgG Fc receptor II beta (mouse)|Fcgr2|mFcgr2|Fc-gamma-RIIB (mouse)|Fcgr2b|FcRII (mouse)|Ly-17|CD32 (mouse)	http://purl.obolibrary.org/obo/PR_P08101		
HP:0030748	biolink:PhenotypicFeature	Grade I preterm intraventricular hemorrhage	Intraventricular hemorrhage that occurs in a preterm infant and that is restricted to subependymal region/germline matrix which is seen in the caudothalamic groove.	UMLS:C0475737|SNOMEDCT_US:276650005	hp.json	Grade I preterm intraventricular haemorrhage|Germinal matrix haemorrhage|Germinal matrix hemorrhage	http://purl.obolibrary.org/obo/HP_0030748		
HP:0003119	biolink:PhenotypicFeature	Abnormal circulating lipid concentration	Any deviation from the normal concentration of a lipid in the blood circulation.	UMLS:C0242339|MSH:D050171|SNOMEDCT_US:370992007|UMLS:C4025650	hp.json	Dyslipidaemia|Dyslipidemia	http://purl.obolibrary.org/obo/HP_0003119		
HP:0030741	biolink:PhenotypicFeature	Mediastinal teratoma	A teratoma located within the mediastinum (the cavity between the pleural sacs that contains the heart and all of the thoracic viscera except the lungs).	UMLS:C1334682|NCIT:C6438	hp.json	Teratoma of the mediastinum	http://purl.obolibrary.org/obo/HP_0030741		
HP:0003118	biolink:PhenotypicFeature	Increased circulating cortisol level	Overproduction of the hormone of cortisol by the adrenal cortex, resulting in a characteristic combination of clinical symptoms termed Cushing syndrome, with truncal obesity, a round, full face, striae atrophicae and acne, muscle weakness, and other features.	SNOMEDCT_US:237735008|UMLS:C0001622|UMLS:C4025651|UMLS:C0342443|MSH:D000308|SNOMEDCT_US:275437005|SNOMEDCT_US:47270006	hp.json	Hypercortisolism|Increased circulating cortisol level|Cushing syndrome|Increased cortisol production	http://purl.obolibrary.org/obo/HP_0003118		
HP:0030742	biolink:PhenotypicFeature	Glial remnants posterior to lens	This anomaly, also known as Mittendorf dot, is a benign, nonprogressive recognizable lesion that does not cause visual impairment. However, it can resemble a pathological congenital or acquired cataract lesion which may enlarge and cause visual impairment. The dot appears as a black speck that ranges in size from the dot made by a sharp pencil point to the size of a poppy seed. It is usually well defined, although occasionally there may be irregular, fine lines radiating outward from the dot.	SNOMEDCT_US:370483001|UMLS:C1299892	hp.json	Mittendorf dot	http://purl.obolibrary.org/obo/HP_0030742		
HP:0005775	biolink:PhenotypicFeature	Multiple skeletal anomalies		UMLS:C4025138	hp.json		http://purl.obolibrary.org/obo/HP_0005775		
HP:0005776	biolink:PhenotypicFeature	Carpal bone malsegmentation		UMLS:C4025137	hp.json		http://purl.obolibrary.org/obo/HP_0005776		
HP:0003117	biolink:PhenotypicFeature	Abnormal circulating hormone concentration	An abnormal concentration of a hormone in the blood.	UMLS:C4025652	hp.json	Abnormal circulating hormone level|Abnormality of circulating hormone level	http://purl.obolibrary.org/obo/HP_0003117		
HP:0030743	biolink:PhenotypicFeature	Glial remnants anterior to the optic disc	Persistance of a posterior remnant of the hyaloid artery located at the optic disc.	UMLS:C4280791	hp.json	Bergmeister papilla	http://purl.obolibrary.org/obo/HP_0030743		
HP:0030744	biolink:PhenotypicFeature	Hyaloid vascular remnant and retrolental mass	A type of persistance of the hyaloid vascular system associated with a retrolental mass that may lead to fetal cataract.	UMLS:C4280790	hp.json		http://purl.obolibrary.org/obo/HP_0030744		
HP:0003116	biolink:PhenotypicFeature	Abnormal echocardiogram			hp.json		http://purl.obolibrary.org/obo/HP_0003116		
HP:0005772	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the tibia	Absence or underdevelopment of the tibia.	UMLS:C1969181	hp.json	Absent/hypoplastic tibia|Absent/underdeveloped shinbone|Absent/small shankbone|Absent/small shinbone|Aplastic/hypoplastic tibia|Absent/underdeveloped shankbone	http://purl.obolibrary.org/obo/HP_0005772		
HP:0005773	biolink:PhenotypicFeature	Short forearm	Underdevelopment of both forearm bones, the ulna and the radius, resulting in a shortened forearm.	UMLS:C1855299	hp.json	Short forearm	http://purl.obolibrary.org/obo/HP_0005773		
HP:0003111	biolink:PhenotypicFeature	Abnormal blood ion concentration	Abnormality of the homeostasis (concentration) of a monoatomic ion.	UMLS:C4025654|SNOMEDCT_US:237840007|UMLS:C1704431	hp.json	Electrolyte disturbance|Abnormality of ion homeostasis|Electrolyte disorders	http://purl.obolibrary.org/obo/HP_0003111		
HP:0030749	biolink:PhenotypicFeature	Grade II preterm intraventricular hemorrhage	Intraventricular hemorrhage that occurs in a preterm infant and that has extension into normal-sized ventricles and typically fills less than 50% of the volume of the ventricle.	UMLS:C4280788	hp.json	Grade II preterm intraventricular haemorrhage	http://purl.obolibrary.org/obo/HP_0030749		
HP:0003110	biolink:PhenotypicFeature	Abnormality of urine homeostasis	An abnormality of the composition of urine or the levels of its components.	UMLS:C4025655	hp.json	Pee issues|Urine issues	http://purl.obolibrary.org/obo/HP_0003110		
MPATH:119	biolink:NamedThing	hemorrhage and non-specified extravasation	Abnormal release of whole blood or the cellular component from the circulation.		hp.json		http://purl.obolibrary.org/obo/MPATH_119		
UBERON:0015010	biolink:AnatomicalEntity	sacral vertebra endochondral element	A vertebra endochondral element that is part of the sacral region of the vertebral column.		hp.json	sacral vertebra element|sacral vertebra skeletal element	http://purl.obolibrary.org/obo/UBERON_0015010		
UBERON:0017671	biolink:AnatomicalEntity	bony part of vertebral arch of first sacral vertebra	A bony part of vertebral arch that is part of a sacral vertebra 1.	FMA:32395	hp.json	bony part of vertebral arch of first sacral segment	http://purl.obolibrary.org/obo/UBERON_0017671		pheno_slim
UBERON:0017672	biolink:AnatomicalEntity	abdominal viscera	A viscus that is part of a abdomen.	FMA:32413|FMA:67355	hp.json	set of abdominal viscera|abdominal viscera set|abdominal viscera	http://purl.obolibrary.org/obo/UBERON_0017672		pheno_slim
UBERON:0017670	biolink:AnatomicalEntity	bony part of cervical vertebral arch	A bony part of vertebral arch that is part of a cervical vertebral arch.	FMA:29794	hp.json	bony part of arch of cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0017670		pheno_slim
UBERON:0015018	biolink:AnatomicalEntity	malleus endochondral element	A malleus bone or its cartilage or pre-cartilage precursor.		hp.json	malleus skeletal element|malleus element|malleus	http://purl.obolibrary.org/obo/UBERON_0015018		
UBERON:0015017	biolink:AnatomicalEntity	incus endochondral element	An incus bone or its cartilage or pre-cartilage precursor.		hp.json	incus skeletal element|incus element	http://purl.obolibrary.org/obo/UBERON_0015017		
HP:0030750	biolink:PhenotypicFeature	Grade III preterm intraventricular hemorrhage	Intraventricular hemorrhage that occurs in a preterm infant and that has extension into dilated ventricles.	UMLS:C4280787	hp.json	Grade III preterm intraventricular haemorrhage	http://purl.obolibrary.org/obo/HP_0030750		
HP:0030751	biolink:PhenotypicFeature	Grade IV preterm intraventricular hemorrhage	Intraventricular hemorrhage that occurs in a preterm infant and that shows parenchymal extension.	UMLS:C4280786	hp.json	Grade IV preterm intraventricular haemorrhage	http://purl.obolibrary.org/obo/HP_0030751		
UBERON:0015019	biolink:AnatomicalEntity	rib endochondral element	A rib bone or its cartilage or pre-cartilage precursor.		hp.json	rib skeletal element|rib element	http://purl.obolibrary.org/obo/UBERON_0015019		
UBERON:0015014	biolink:AnatomicalEntity	calcaneum endochondral element	A calcaneum bone or its cartilage or pre-cartilage precursor.		hp.json	calcaneum skeletal element|calcaneum element	http://purl.obolibrary.org/obo/UBERON_0015014		
UBERON:0015013	biolink:AnatomicalEntity	fibula endochondral element	The major postaxial endochondral element in the posterior zeugopod[Phenoscape].		hp.json	fibula skeletal element|fibula element	http://purl.obolibrary.org/obo/UBERON_0015013		
UBERON:0015016	biolink:AnatomicalEntity	stapes endochondral element	A stapes bone or its cartilage or pre-cartilage precursor.		hp.json	stapes skeletal element|stapes element	http://purl.obolibrary.org/obo/UBERON_0015016		
HP:0030756	biolink:PhenotypicFeature	Erythrodontia	Reddish, brown opalescent discoloration of teeth in normal light.	UMLS:C4280783	hp.json	Red teeth	http://purl.obolibrary.org/obo/HP_0030756		
UBERON:0005695	biolink:AnatomicalEntity	manual digit 5 mesenchyme	Mesenchyme that is part of a developing manual digit 5.	EHDAA2:0000537|EMAPA:17443	hp.json	hand digit 5 mesenchyme|fore limb digit 5 mesenchyme|manual digit V mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005695		
HP:0005745	biolink:PhenotypicFeature	Congenital foot contractures		UMLS:C4025144	hp.json		http://purl.obolibrary.org/obo/HP_0005745		
HP:0030757	biolink:PhenotypicFeature	Tooth abscess	A pocket of pus located within a region of a tooth.	UMLS:C0518988|SNOMEDCT_US:299709002	hp.json	Dental abscess|Dentoalveolar abscess	http://purl.obolibrary.org/obo/HP_0030757		
HP:0005746	biolink:PhenotypicFeature	Osteosclerosis of the base of the skull	An increase in bone density affecting the basicranium (base of the skull).	UMLS:C4021624	hp.json	Osteosclerosis of the skull base	http://purl.obolibrary.org/obo/HP_0005746		
UBERON:0005694	biolink:AnatomicalEntity	manual digit 4 mesenchyme	Mesenchyme that is part of a developing manual digit 4.	EMAPA:17440|EHDAA2:0000531	hp.json	hand digit 4 mesenchyme|fore limb digit 4 mesenchyme|manual digit IV mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005694		
HP:0030758	biolink:PhenotypicFeature	Periapical tooth abscess	A tooth abscess that occurs at the tip of the root (apex) of a tooth.	UMLS:C4280782	hp.json		http://purl.obolibrary.org/obo/HP_0030758		
UBERON:0005693	biolink:AnatomicalEntity	manual digit 3 mesenchyme	Mesenchyme that is part of a developing manual digit 3.	EMAPA:17437|EHDAA2:0000525	hp.json	manual digit III mesenchyme|hand digit 3 mesenchyme|fore limb digit 3 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005693		
HP:0005747	biolink:PhenotypicFeature	Easily subluxated first metacarpophalangeal joints		UMLS:C4025143	hp.json		http://purl.obolibrary.org/obo/HP_0005747		
UBERON:0005692	biolink:AnatomicalEntity	manual digit 2 mesenchyme	Mesenchyme that is part of a developing manual digit 2.	EHDAA2:0000519|EMAPA:17434	hp.json	manual digit II mesenchyme|hand digit 2 mesenchyme|fore limb digit 2 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005692		
HP:0030759	biolink:PhenotypicFeature	Adipocyte hypertrophy	An increase in mean adipocyte cell size. This feature can be measured by determining the average cell diameter of adipocytes microscopically using abdominal subcutaneous adipose tissue obtained by biopsy.	UMLS:C4280781	hp.json	Fat cell hypertrophy	http://purl.obolibrary.org/obo/HP_0030759		
UBERON:0005691	biolink:AnatomicalEntity	4th arch mesenchyme	Mesenchyme that is part of a pharyngeal arch 4.	EHDAA2:0000096|EHDAA:1677|VHOG:0001052|FMA:295702|EMAPA:16770	hp.json	4th pharyngeal arch mesenchyme|4th branchial arch mesenchyme|pharyngeal arch 4 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005691		
HP:0030752	biolink:PhenotypicFeature	Dacryocystocele	A nasolacrimal duct obstruction presenting as a grey-blue cystic swelling just below the medial canthus. Believed to be a result of concomitant upper obstruction of the Rosenmuller valve and lower obstruction of the Hasner valve.	UMLS:C0155241|SNOMEDCT_US:42758002	hp.json	Timo cyst	http://purl.obolibrary.org/obo/HP_0030752		
UBERON:0005690	biolink:AnatomicalEntity	3rd arch mesenchyme	Mesenchyme that is part of a pharyngeal arch 3.	EHDAA:1094|EMAPA:16402|EHDAA2:0000081|VHOG:0001083|FMA:295700	hp.json	3rd branchial arch mesenchyme|pharyngeal arch 3 mesenchyme|3rd pharyngeal arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005690		
HP:0030753	biolink:PhenotypicFeature	Intrauterine fetal demise of one twin after midgestation	Loss of one twin occurring after midgestation (17 weeks gestation).	UMLS:C4280785	hp.json	Intrauterine foetal demise of one twin after midgestation|Single-twin demise	http://purl.obolibrary.org/obo/HP_0030753		
HP:0005743	biolink:PhenotypicFeature	Avascular necrosis of the capital femoral epiphysis	Avascular necrosis of the proximal epiphysis of the femur occurring in growing children and caused by an interruption of the blood supply to the head of the femur close to the hip joint. The necrosis is characteristically associated with flattening of the femoral head, for which reason the term coxa plana has been used to refer to this feature in the medical literature.	SNOMEDCT_US:111255008|ICD-10:M91.1|SNOMEDCT_US:240241003|UMLS:C0023234|MSH:D007873	hp.json	Perthes-like femoral head changes|Legg-Perthes disease|Legg-Calve-Perthes syndrome|Osteonecrosis of the femoral head|Coxa plana|Osteochondrosis of the femoral head|Morbus Legg-Calve-Perthes	http://purl.obolibrary.org/obo/HP_0005743		
HP:0030754	biolink:PhenotypicFeature	Allantoic cyst	A swelling formed at the base of umbilicus associated with a patent urachus which results from an allantoic remnant. The urachus is a fibrous remnant of the allantois which communicates from the apex of the urinary bladder to the umbilicus. Failed obliteration of the urachus can lead to various abnormalities: urachal cyst, urachal diverticulum, sinus or patent urachus - the most common type. Allantoic cysts in infants with patent urachus can be formed due to the drainage of urine into the umbilical cord, or in uncommon situations, after leakage of hypo-osmotic urine into the Wharton's jelly.	MSH:D014496|SNOMEDCT_US:17234001|UMLS:C0041915	hp.json		http://purl.obolibrary.org/obo/HP_0030754		
HP:0030755	biolink:PhenotypicFeature	Craniofacial teratoma	A teratoma located in the craniofacial region.	UMLS:C4280784|NCIT:C3403	hp.json		http://purl.obolibrary.org/obo/HP_0030755		
HP:0005744	biolink:PhenotypicFeature	obsolete Generalized osteoporosis with pathologic fractures			hp.json		http://purl.obolibrary.org/obo/HP_0005744		
MPATH:105	biolink:NamedThing	circulatory disorder	Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body.		hp.json		http://purl.obolibrary.org/obo/MPATH_105		
UBERON:0003038	biolink:AnatomicalEntity	thoracic spinal cord	The thoracic nerves are the spinal nerves emerging from the thoracic vertebrae. [WP,unvetted].	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1718|BIRNLEX:966|NCIT:C12894|FMA:71167|UMLS:C0581620|Wikipedia:Thoracic_spinal_cord|UMLS:C0581620|MA:0003082|SCTID:278750009	hp.json	thoracic segment of spinal cord|pars thoracica medullae spinalis|thoracic segments of spinal cord [1-12]|thoracic region of spinal cord|segmenta thoracica medullae spinalis [1-12]|thoracic spinal cord	http://purl.obolibrary.org/obo/UBERON_0003038		uberon_slim
UBERON:0003039	biolink:AnatomicalEntity	anterior commissure anterior part	The horseshoe-shaped tract that connects the two olfactory bulbs.	FMA:61963|MBA:900|BAMS:aca|EMAPA:37404|BAMS:aco|BIRNLEX:969	hp.json	commissura anterior, pars anterior|commissura anterior, crus anterius|pars anterior|olfactory limb of anterior commissure|olfactory part of anterior commissure|anterior commissure, anterior part|commissura anterior, pars olfactoria|anterior commissure olfactory limb|anterior part of anterior commissure|anterior commissure pars anterior|anterior commissure, olfactory limb|anterior part of anterior commissure|pars anterior commissurae anterioris|pars olfactoria commissurae anterioris|commissura rostralis, pars anterior	http://purl.obolibrary.org/obo/UBERON_0003039		pheno_slim
UBERON:0005699	biolink:AnatomicalEntity	pedal digit 5 mesenchyme	Mesenchyme that is part of a developing pedal digit 5.	EHDAA2:0002059|EMAPA:17474	hp.json	hind limb digit 5 mesenchyme|pedal digit V mesenchyme|foot digit 5 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005699		
UBERON:0003037	biolink:AnatomicalEntity	septum	A wall, dividing a cavity or structure into smaller ones[WP].	AAO:0011127|OpenCyc:Mx4rrqot_on_EdaAAAACs0uFOQ|Wikipedia:Septum|FMA:86461	hp.json	septa	http://purl.obolibrary.org/obo/UBERON_0003037		pheno_slim
UBERON:0005698	biolink:AnatomicalEntity	pedal digit 4 mesenchyme	Mesenchyme that is part of a developing pedal digit 4.	EMAPA:17471|EHDAA2:0002054	hp.json	foot digit 4 mesenchyme|pedal digit IV mesenchyme|hind limb digit 4 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005698		
UBERON:0005697	biolink:AnatomicalEntity	pedal digit 3 mesenchyme	Mesenchyme that is part of a developing pedal digit 3.	EMAPA:17468|EHDAA2:0002049	hp.json	foot digit 3 mesenchyme|pedal digit III mesenchyme|hind limb digit 3 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005697		
UBERON:0005696	biolink:AnatomicalEntity	pedal digit 2 mesenchyme	Mesenchyme that is part of a developing pedal digit 2.	EHDAA2:0002044|EMAPA:17465	hp.json	foot digit 2 mesenchyme|hind limb digit 2 mesenchyme|pedal digit II mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005696		
UBERON:0015001	biolink:AnatomicalEntity	radius endochondral element	The major preaxial endrochondral skeletal element in the anterior zeugopod.		hp.json	radius element|radius skeletal element	http://purl.obolibrary.org/obo/UBERON_0015001		
UBERON:0015007	biolink:AnatomicalEntity	cervical vertebra endochondral element	A vertebral endochondral element in the cervical region of the vertebral column.		hp.json	cervical vertebra element|cervical vertebra skeletal element	http://purl.obolibrary.org/obo/UBERON_0015007		
HP:0030760	biolink:PhenotypicFeature	Renal fibrosis	Renal fibrosis is the consequence of an excessive accumulation of extracellular matrix that occurs in virtually every type of chronic kidney disease.	UMLS:C0151650|SNOMEDCT_US:197660000	hp.json	Kidney fibrosis	http://purl.obolibrary.org/obo/HP_0030760		
HGNC:4057	biolink:Gene	G6PD (human)	A protein coding gene G6PD in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4057		
HP:0030761	biolink:PhenotypicFeature	obsolete Renal glomerular fibrosis			hp.json		http://purl.obolibrary.org/obo/HP_0030761		
UBERON:0015009	biolink:AnatomicalEntity	lumbar vertebra endochondral element	A lumbar vertebra bone or its cartilage or pre-cartilage precursor.		hp.json	lumbar vertebra skeletal element|lumbar vertebra element	http://purl.obolibrary.org/obo/UBERON_0015009		
UBERON:0015008	biolink:AnatomicalEntity	thoracic vertebra endochondral element	A vertebral endochondral element in the thoracic region of the vertebral column.		hp.json	thoracic vertebra element|thoracic vertebra skeletal element	http://purl.obolibrary.org/obo/UBERON_0015008		
HP:0030762	biolink:PhenotypicFeature	Mesangiolysis	Partial or complete dissolution of the mesangial matrix, identified by reduced staining on a periodic acid-Schiff (PAS) or silver stain.	UMLS:C4054531	hp.json		http://purl.obolibrary.org/obo/HP_0030762		
UBERON:0015003	biolink:AnatomicalEntity	ulna endochondral element	Major postaxial endrochondral skeletal element in the anterior zeugopod.		hp.json	ulna skeletal element|ulna element	http://purl.obolibrary.org/obo/UBERON_0015003		
UBERON:0015002	biolink:AnatomicalEntity	radius-ulna endochondral element	A radius-ulna bone or its cartilage or pre-cartilage precursor.		hp.json	radius-ulna element|radius-ulna skeletal element	http://purl.obolibrary.org/obo/UBERON_0015002		
UBERON:0015004	biolink:AnatomicalEntity	tibia endochondral element	The major preaxial endochondral element in the posterior zeugopod[Phenoscape].		hp.json	tibia skeletal element|tibia element	http://purl.obolibrary.org/obo/UBERON_0015004		
HP:0005756	biolink:PhenotypicFeature	Neonatal epiphyseal stippling	The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses during the neonatal period.	UMLS:C4021623	hp.json	Speckled calcifications in bone end parts in neonates|Epiphyseal stippling in neonates	http://purl.obolibrary.org/obo/HP_0005756		
HP:0030767	biolink:PhenotypicFeature	Epignathus	Epignathus is a teratoma originating from the upper jaw, usually connected with the sphenoid bone or hard palate.	SNOMEDCT_US:31248004|UMLS:C0266725	hp.json		http://purl.obolibrary.org/obo/HP_0030767		
HP:0030769	biolink:PhenotypicFeature	Exencephaly	A malformation of the neural tube with a large amount of protruding brain tissue and absence of calvarium.	SNOMEDCT_US:84461004|MSH:D009436|UMLS:C0266453	hp.json		http://purl.obolibrary.org/obo/HP_0030769		
HP:0005758	biolink:PhenotypicFeature	Basilar impression	Abnormal elevation of the floor of the posterior fossa including occipital condyles and foramen magnum.	UMLS:C0032209|SNOMEDCT_US:86587003|MSH:D010985	hp.json		http://purl.obolibrary.org/obo/HP_0005758		
HP:0005759	biolink:PhenotypicFeature	Small flat posterior fossa	An abnormally small and flat configuration of the posterior cranial fossa.	UMLS:C4025141	hp.json	Small and flat posterior skull bones|Small and flat posterior fossa of skull	http://purl.obolibrary.org/obo/HP_0005759		
HP:0030763	biolink:PhenotypicFeature	Amniotic Sheet	A sheet like projection that can result from uterine synechiae that has been encompassed by the expanding chorion and amnion.	UMLS:C4280779	hp.json	Amniotic shelf	http://purl.obolibrary.org/obo/HP_0030763		
HP:0005752	biolink:PhenotypicFeature	Flattened moderately deformed vertebrae		UMLS:C4025142	hp.json		http://purl.obolibrary.org/obo/HP_0005752		
HP:0030764	biolink:PhenotypicFeature	Ochronosis	Brown or blue-gray discoloration of the skin that can present on the axillary and inguinal areas, face, palms or soles. In addition, blue-black discoloration can be apparent on skin overlying cartilage in which the pigment is deposited, such as the ears. This is a characteristic manifestation of alkaptonuria, which is an autosomal recessively inherited deficiency of homogentisic acid oxidase that results in accumulation of homogentisic acid in collagenous structures. The sclerae are also typically involved.	MSH:D009794|UMLS:C0028817|SNOMEDCT_US:410042009	hp.json		http://purl.obolibrary.org/obo/HP_0030764		
HP:0030765	biolink:PhenotypicFeature	Sleep terror	Episodes of intense fear, screaming and flailing although affected individuals are still asleep.	UMLS:C0037320|MSH:D020184|SNOMEDCT_US:89675003	hp.json	Sleep terrors|Pavor nocturnus|Night terror	http://purl.obolibrary.org/obo/HP_0030765		
HP:0030766	biolink:PhenotypicFeature	Ear pain	Pain in the ear can be a consequence of otologic disease (primary or otogenic otalgia), or can arise from pathologic processes and structures other than the ear (secondary or referred otalgia).	SNOMEDCT_US:16001004|MSH:D004433|UMLS:C0013456|SNOMEDCT_US:162356005	hp.json	Ear pain|Otalgia|Pain in the ear	http://purl.obolibrary.org/obo/HP_0030766		
HP:0005750	biolink:PhenotypicFeature	Lower-limb joint contracture	A limitation in the passive range of motion of a joint of the lower limb resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin.	UMLS:C1859523	hp.json	Contractures, lower limbs|Contractures of the joints of the lower limbs	http://purl.obolibrary.org/obo/HP_0005750		
UBERON:0005689	biolink:AnatomicalEntity	2nd arch mesenchyme	Mesenchyme that is part of a pharyngeal arch 2.	EHDAA2:0000066|FMA:295698|VHOG:0001102|EHDAA:625|EMAPA:16279	hp.json	2nd branchial arch mesenchyme|pharyngeal arch 2 mesenchyme|2nd pharyngeal arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005689		
UBERON:0005688	biolink:AnatomicalEntity	lens vesicle cavity	An anatomical cavity that is part of a lens vesicle.	EMAPA:17164|VHOG:0000531|EHDAA2:0000986	hp.json	cavity of lens vesicle|cavity of lens|lens cavity	http://purl.obolibrary.org/obo/UBERON_0005688		
UBERON:0005687	biolink:AnatomicalEntity	orbitosphenoid cartilage element	An orbitosphenoid endochondral element that is composed primarily of cartilage tissue.	EHDAA:9554|EHDAA2:0001329	hp.json	sphenoid lesser wing cartilage element	http://purl.obolibrary.org/obo/UBERON_0005687		
UBERON:0003023	biolink:AnatomicalEntity	pontine tegmentum	Dorsal portion of the pons, containing cranial nervee nuclei, ascending and descending tracts and reticular nuclei. It is continuous with the reticular formation of the medulla (Carpenter, A Core Text of Neuroanatomy, 3rd ed, 1985, pg 133).	SCTID:362401009|Wikipedia:Pontine_tegmentum|DHBA:12416|FMA:71108|MESH:D065821|BAMS:PTg|HBA:9135|BIRNLEX:923|UMLS:C0228426|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=557	hp.json	dorsal pons|tegmentum of pons|tegmentum pontis|tegmental portion of pons|pars dorsalis pontis|pars posterior pontis|tegmentum pontis|tegmentum pontis|dorsal portion of pons	http://purl.obolibrary.org/obo/UBERON_0003023		human_reference_atlas|uberon_slim
UBERON:0005685	biolink:AnatomicalEntity	midgut dorsal mesentery	A dorsal mesentery that is part of a midgut.	EMAPA:18671|EMAPA:17040|EMAPA:16722|RETIRED_EHDAA2:0001187	hp.json		http://purl.obolibrary.org/obo/UBERON_0005685		
UBERON:0015078	biolink:AnatomicalEntity	proximal carpal endochondral element	A proximal mesopodial endochondral element that is part of a forelimb.		hp.json	proximal carpal|proximal carpal element	http://purl.obolibrary.org/obo/UBERON_0015078		
UBERON:0015077	biolink:AnatomicalEntity	centrale cartilage	A centrale endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015077		
UBERON:0003091	biolink:AnatomicalEntity	thyroid primordium	The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus.	EHDAA:952|AAO:0011106|NCIT:C34312|EMAPA:16361|UMLS:C1519512|EHDAA2:0002033|ZFA:0001081|XAO:0000444|TAO:0001081|BTO:0004709	hp.json	thyroid primordia	http://purl.obolibrary.org/obo/UBERON_0003091		vertebrate_core
UBERON:0015079	biolink:AnatomicalEntity	proximal carpal cartilage	A proximal carpal endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015079		
UBERON:0003098	biolink:AnatomicalEntity	optic stalk	The narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain.	EHDAA2:0001318|ZFA:0000137|XAO:0000475|TAO:0000137|NCIT:C34235|UMLS:C0231107|AAO:0011077|VHOG:0000223|EHDAA:3816|EMAPA:16678	hp.json	pedunculus opticus|optic stalks	http://purl.obolibrary.org/obo/UBERON_0003098		uberon_slim|vertebrate_core|pheno_slim
HP:0003148	biolink:PhenotypicFeature	Elevated serum acid phosphatase		UMLS:C1839866	hp.json	Elevated serum acid phosphatase|Acid phosphatase elevated	http://purl.obolibrary.org/obo/HP_0003148		
UBERON:0003099	biolink:AnatomicalEntity	cranial neural crest	Neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage.	Wikipedia:Cranial_neural_crest|VHOG:0000063|XAO:0001001|EFO:0003645|ZFA:0001194|EHDAA2:0004420|TAO:0001194|EMAPA:16091|AAO:0010580	hp.json	head crest|head neural crest|crista neuralis cranialis|head NCC population|crista neuralis cranialis|CNC|cranial NCC population|cephalic neural crest	http://purl.obolibrary.org/obo/UBERON_0003099		uberon_slim|vertebrate_core|efo_slim
HP:0003146	biolink:PhenotypicFeature	Hypocholesterolemia	An decreased concentration of cholesterol in the blood.	UMLS:C0151718|SNOMEDCT_US:61336008	hp.json	Decreased circulating cholesterol level	http://purl.obolibrary.org/obo/HP_0003146		
HP:0003145	biolink:PhenotypicFeature	Decreased adenosylcobalamin	Decreased concentration of adenosylcobalamin. Adenosylcobalamin is one of the active forms of vitamin B12.	UMLS:C1848556	hp.json	Decreased ADOCBL	http://purl.obolibrary.org/obo/HP_0003145		
HP:0003149	biolink:PhenotypicFeature	Hyperuricosuria	An abnormally high level of uric acid in the urine.	UMLS:C0948643	hp.json	Increased urinary urate|High urine uric acid level	http://purl.obolibrary.org/obo/HP_0003149		
HP:0003140	biolink:PhenotypicFeature	T-wave inversion in the right precordial leads		UMLS:C4025646	hp.json		http://purl.obolibrary.org/obo/HP_0003140		
HP:0003144	biolink:PhenotypicFeature	Increased serum serotonin	A increased concentration of serotonin in the blood.	UMLS:C0877243	hp.json	Increased serum serotonin	http://purl.obolibrary.org/obo/HP_0003144		
HP:0003142	biolink:PhenotypicFeature	Excessive purine production		UMLS:C4025645	hp.json		http://purl.obolibrary.org/obo/HP_0003142		
HP:0003141	biolink:PhenotypicFeature	Increased LDL cholesterol concentration	An elevated concentration of low-density lipoprotein cholesterol in the blood.	SNOMEDCT_US:398036000|SNOMEDCT_US:190773008|MSH:D006938|UMLS:C0549399|UMLS:C0020445	hp.json	Hyperbetalipoproteinemia|Increased beta-lipoproteins|Increased circulating low-density lipoprotein cholesterol|Increased circulating low-density lipoprotein levels|Increased circulating LDL level|Increased plasma LDL levels|Increased LDLc concentration|Increased LDL cholesterol	http://purl.obolibrary.org/obo/HP_0003141		
UBERON:0015064	biolink:AnatomicalEntity	autopod cartilage	An autopod endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015064		
UBERON:0015067	biolink:AnatomicalEntity	centrale endochondral element	Endochondral element located between the proximal and distal rows of carpals or tarsals and thus representing the central carpals or tarsals[PHENOSCAPE].		hp.json	central mesopodium element|centralia	http://purl.obolibrary.org/obo/UBERON_0015067		
UBERON:0015061	biolink:AnatomicalEntity	limb endochondral element	A limb bone or its cartilage or pre-cartilage precursor.		hp.json	limb bone skeletal element|limb bone endochondral element	http://purl.obolibrary.org/obo/UBERON_0015061		
UBERON:0015060	biolink:AnatomicalEntity	sphenoid endochondral element	A sphenoid bone or its cartilage or pre-cartilage precursor.		hp.json	sphenoid element|sphenoid bone skeletal element	http://purl.obolibrary.org/obo/UBERON_0015060		
UBERON:0015063	biolink:AnatomicalEntity	autopod endochondral element	An endochondral element that is part of a autopod region.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015063		
UBERON:0003080	biolink:AnatomicalEntity	anterior neural tube		VHOG:0001384|ZFA:0007038|XAO:0000307|TAO:0007038|AAO:0011012	hp.json		http://purl.obolibrary.org/obo/UBERON_0003080		
UBERON:0015069	biolink:AnatomicalEntity	distal carpal cartilage element	A distal carpal endochondral element that is composed primarily of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015069		
UBERON:0015068	biolink:AnatomicalEntity	distal carpal endochondral element	A distal mesopodial endochondral element that is part of a forelimb.		hp.json	distal carpal|distal carpal	http://purl.obolibrary.org/obo/UBERON_0015068		
HP:0003159	biolink:PhenotypicFeature	Hyperoxaluria	Increased excretion of oxalates in the urine.	SNOMEDCT_US:367621000119107|MSH:D006959|UMLS:C0020500	hp.json	High urine oxalate levels|Increased level of oxalate in urine	http://purl.obolibrary.org/obo/HP_0003159		
HP:0003158	biolink:PhenotypicFeature	Hyposthenuria	An abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine.	SNOMEDCT_US:76023003|UMLS:C0232831	hp.json	Reduced urinary osmolality	http://purl.obolibrary.org/obo/HP_0003158		
UBERON:0003086	biolink:AnatomicalEntity	caudal artery	Extension of the dorsal aorta in the tail.	EFO:0003472|XAO:0000364|ZFA:0000011|TAO:0000011|AAO:0011023|VHOG:0000123	hp.json	CA	http://purl.obolibrary.org/obo/UBERON_0003086		uberon_slim|efo_slim
UBERON:0003083	biolink:AnatomicalEntity	trunk neural crest	Trunk portion of the neural crest. The trunk neural crest lies between the vagal and sacral neural crest and gives rise to two groups of cells. One group migrates dorsolateral and populates the skin, forming pigment cells and the other migrates ventrolateral through the anterior sclerotome to become the epinephrine-producing cells of the adrenal gland and the neurons of the sympathetic nervous system. Some cells remain in the sclerotome to form the dorsal root ganglia [Wikipedia].	EHDAA2:0001901|VHOG:0000062|EFO:0003605|ZFA:0001024|TAO:0001024|XAO:0000319|AAO:0010582|Wikipedia:Trunk_neural_crest	hp.json	TNC|trunk crest	http://purl.obolibrary.org/obo/UBERON_0003083		efo_slim|uberon_slim
UBERON:0003084	biolink:AnatomicalEntity	heart primordium	Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.	TAO:0000028|UMLS:C1514450|BTO:0001887|NCIT:C34276|AAO:0011044|XAO:0000336|ZFA:0000028	hp.json	cardiac field|fused heart primordium	http://purl.obolibrary.org/obo/UBERON_0003084		uberon_slim
UBERON:0003081	biolink:AnatomicalEntity	lateral plate mesoderm	Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP].	UMLS:C1517749|XAO:0000311|EMAPA:16179|EHDAA:379|ZFA:0000121|FMA:293149|AAO:0010574|VHOG:0000118|EHDAA2:0000919|TAO:0000121|NCIT:C34199|SCTID:361477005|Wikipedia:Lateral_plate_mesoderm	hp.json	lateral plate mesenchyme|mesoderma laminae lateralis|LPM|lateral mesoderm|lateral plate|mesoderma laminae lateralis	http://purl.obolibrary.org/obo/UBERON_0003081		pheno_slim|uberon_slim
UBERON:0003082	biolink:AnatomicalEntity	myotome	A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells.	EHDAA:1733|EHDAA:1721|FMA:295658|UMLS:C1513802|ZFA:0001056|NCIT:C34214|TAO:0001056|BTO:0000742|AEO:0001018|AAO:0011067|EMAPA:32841|EHDAA:1739|EHDAA:1727|Wikipedia:Myotome|XAO:0000315|SCTID:344535001|VHOG:0001244|EHDAA2_RETIRED:0003431	hp.json	myomeres|myomere|myotomus|myotome region|myotomes|myotomus|muscle plate	http://purl.obolibrary.org/obo/UBERON_0003082		vertebrate_core|pheno_slim|uberon_slim
HP:0030709	biolink:PhenotypicFeature	Myelocystocele	Myelocystocele is characterized by a large, ependyma-lined, cystic dilation of the caudal end of the central canal of the spinal cord; it projects dorsally through a lamina defect, with overlying varying amounts of lipomatous subcutaneous tissue. Myelocystoceles are associated with a tethered cord and meningocele, which communicates with the spinal subarachnoid space, but not with the central canal cyst.	MSH:D008591|SNOMEDCT_US:203994003|SNOMEDCT_US:414667000|UMLS:C0025312	hp.json		http://purl.obolibrary.org/obo/HP_0030709		
HP:0003150	biolink:PhenotypicFeature	Glutaric aciduria	An increased concentration of glutaric acid in the urine.	UMLS:C0268594|SNOMEDCT_US:28987007	hp.json	Glutaricaciduria|Glutarate aciduria|Increased glutarate level in urine	http://purl.obolibrary.org/obo/HP_0003150		
HP:0003155	biolink:PhenotypicFeature	Elevated circulating alkaline phosphatase concentration	Abnormally increased serum levels of alkaline phosphatase activity.	UMLS:C0750857	hp.json	Hyperphosphatasia|Elevated ALP|Greatly elevated alkaline phosphatase|Increased alkaline phosphatase|Hyperphosphatasemia|Increased serum alkaline phosphatase|High serum alkaline phosphatase|Elevated alkaline phosphatase	http://purl.obolibrary.org/obo/HP_0003155		
HP:0003154	biolink:PhenotypicFeature	Increased circulating ACTH level	An abnormal increased in the concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), in the blood.	UMLS:C4021740	hp.json	Increased plasma ACTH|High blood corticotropin levels|Increased circulating ACTH level	http://purl.obolibrary.org/obo/HP_0003154		
HP:0030706	biolink:PhenotypicFeature	Ranula	A ranula is a mucocele that occurs in the floor of the mouth and usually involve the major salivary glands. Specifically, the ranula originates in the body of the sublingual gland, in the ducts of the sublingual gland, in the Wharton's duct of the submandibular gland or infrequently from the minor salivary glands at this location.	SNOMEDCT_US:14919007|MSH:D011900|UMLS:C2242813	hp.json	Sublingual ptyalocele|Sublingual cyst	http://purl.obolibrary.org/obo/HP_0030706		
UBERON:0003089	biolink:AnatomicalEntity	sclerotome	Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].	ZFA:0001080|UMLS:C0183176|TAO:0001080|EHDAA2:0003439|VHOG:0000680|XAO:0000397|Wikipedia:Sclerotome|NCIT:C34287|EMAPA:31159|AAO:0010571|FMA:295652|AEO:0000212	hp.json	sclerotomus|sclerotomus|sclerotomes	http://purl.obolibrary.org/obo/UBERON_0003089		uberon_slim|vertebrate_core|pheno_slim
HP:0003153	biolink:PhenotypicFeature	Cystathioninuria	An elevated urinary concentration of cystathionine.	SNOMEDCT_US:13003007|UMLS:C0220993	hp.json	High urine cystathionine levels	http://purl.obolibrary.org/obo/HP_0003153		
HP:0030707	biolink:PhenotypicFeature	Unilateral lung agenesis	Lack of development of one lung.	MSH:C562992|UMLS:C4082952	hp.json	Unilateral pulmonary agenesis	http://purl.obolibrary.org/obo/HP_0030707		
HP:0030708	biolink:PhenotypicFeature	Myeloschisis	The severe form of a neural tube defect where the open neural tube appears as a flattened, plate-like mass of nervous tissue with no overlying membrane.	UMLS:C0266507|SNOMEDCT_US:360530005	hp.json		http://purl.obolibrary.org/obo/HP_0030708		
HP:0003152	biolink:PhenotypicFeature	obsolete Increased serum 1,25-dihydroxyvitamin D3			hp.json		http://purl.obolibrary.org/obo/HP_0003152		
UBERON:0015054	biolink:AnatomicalEntity	iliac endochondral element	An iliac bone or its cartilage or pre-cartilage precursor.		hp.json	iliac element|iliac skeletal element	http://purl.obolibrary.org/obo/UBERON_0015054		
UBERON:0015053	biolink:AnatomicalEntity	humerus endochondral element	A humerus bone or its cartilage or pre-cartilage precursor.		hp.json	humerus element|humerus skeletal element	http://purl.obolibrary.org/obo/UBERON_0015053		
OBO:chebi#has_parent_hydride	biolink:NamedThing	has parent hydride			hp.json		http://purl.obolibrary.org/obo/chebi#has_parent_hydride		
UBERON:0015056	biolink:AnatomicalEntity	ischial endochondral element	An ischial bone or its cartilage or pre-cartilage precursor.		hp.json	ischial skeletal element|ischial element	http://purl.obolibrary.org/obo/UBERON_0015056		
UBERON:0015055	biolink:AnatomicalEntity	pubic endochondral element	A pubic bone or its cartilage or pre-cartilage precursor.		hp.json	pubic skeletal element|pubic element	http://purl.obolibrary.org/obo/UBERON_0015055		
UBERON:0015050	biolink:AnatomicalEntity	tarsus endochondral element	A tarsus bone or its cartilage or pre-cartilage precursor.		hp.json	tarsus element|tarsus skeletal element	http://purl.obolibrary.org/obo/UBERON_0015050		
UBERON:0015052	biolink:AnatomicalEntity	femur endochondral element	A femur bone or its cartilage or pre-cartilage precursor.		hp.json	femur element|femur skeletal element	http://purl.obolibrary.org/obo/UBERON_0015052		
UBERON:0015057	biolink:AnatomicalEntity	scapula endochondral element	A scapula bone or its cartilage or pre-cartilage precursor.		hp.json	scapula element|scapula skeletal element	http://purl.obolibrary.org/obo/UBERON_0015057		
UBERON:0015059	biolink:AnatomicalEntity	orbitosphenoid endochondral element	An orbitosphenoid bone or its cartilage or pre-cartilage precursor.		hp.json	orbitosphenoid element|orbitosphenoid skeletal element	http://purl.obolibrary.org/obo/UBERON_0015059		
HP:0003126	biolink:PhenotypicFeature	Low-molecular-weight proteinuria	Excretion in urine of proteins of a size smaller than albumin (molecular weight 69 kD).	UMLS:C1839606	hp.json	Tubular proteinuria	http://purl.obolibrary.org/obo/HP_0003126		
HP:0030712	biolink:PhenotypicFeature	Uterine synechiae	Adhesions or scar tissue that form inside the cavity of the uterus.	SNOMEDCT_US:48236007|MSH:D006175|UMLS:C0156372	hp.json	Asherman syndrome	http://purl.obolibrary.org/obo/HP_0030712		
UBERON:0003076	biolink:AnatomicalEntity	posterior neural tube		AAO:0011082|VHOG:0001383|XAO:0000250|ZFA:0007037|TAO:0007037	hp.json		http://purl.obolibrary.org/obo/UBERON_0003076		
HP:0005789	biolink:PhenotypicFeature	Generalized osteosclerosis	An abnormal increase of bone mineral density with generalized involvement of the skeleton.	UMLS:C4280476|UMLS:C1843331	hp.json	Generalised osteosclerosis|Increased bone density in skeletal bones|Osteosclerosis, diffuse symmetrical|Diffuse, symmetrical osteosclerosis	http://purl.obolibrary.org/obo/HP_0005789		
UBERON:0003077	biolink:AnatomicalEntity	paraxial mesoderm	The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].	VHOG:0000114|SCTID:361475002|XAO:0000259|Wikipedia:Paraxial_mesoderm|EMAPA:16751|AAO:0010568|ZFA:0000255|TAO:0000255|EFO:0003515|NCIT:C34244|EMAPA:16183|UMLS:C1284009|FMA:293145	hp.json	paraxial mesenchyme|mesoderma paraxiale|mesoderma paraxiale|somitic mesoderm|paraxial mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003077		uberon_slim|vertebrate_core|efo_slim
HP:0003125	biolink:PhenotypicFeature	Reduced factor VIII activity	Reduced activity of coagulation factor VIII. Factor VIII (fVIII) is a cofactor in the intrinsic clotting cascade that is activated to fVIIIa in the presence of minute quantities of thrombin. fVIIIa acts as a receptor, for factors IXa and X.	UMLS:C3494187|MSH:D006467|UMLS:C4025649|SNOMEDCT_US:234440005	hp.json	Factor VIII deficiency	http://purl.obolibrary.org/obo/HP_0003125		
HP:0030713	biolink:PhenotypicFeature	Vein of Galen aneurysmal malformation	Vein of Galen aneurysmal malformation is a choroidal type of arteriovenous malformation that develops between 6 and 11 weeks of gestation. It results from 1 or more arteriovenous fistulas shunting blood toward the prosencephalic vein of Markowski, the embryonic precursor of the vein of Galen. This abnormal shunt leads to progressive dilation of the vein and prevents its involution and subsequent development into the vein of Galen.	MSH:C536535|UMLS:C0431420|SNOMEDCT_US:253194008	hp.json	Median prosencephalic arteriovenous fistula|Vein of Galen malformation|Vein of Galen aneurysm	http://purl.obolibrary.org/obo/HP_0030713		
UBERON:0003074	biolink:AnatomicalEntity	mesonephric duct	Paired organ that connects the primitive kidney Wolffian body (or mesonephros) to the cloaca and serves as the anlage for certain male reproductive organs. the Wolffian duct is what remains of the pronephric duct after the atrophy of the pronephros[WP]. In Zebrafish: Duct of the adult kidney (mesonephros), present bilaterally ventral to the somites and leading to the cloacal chamber[ZFA].	ZFA:0000546|EMAPA:16577|TAO:0000546|AAO:0000637|XAO:0000242|GAID:1315|NCIT:C26469|VHOG:0000082|EHDAA2:0001243|EHDAA:1590|MESH:D014928|UMLS:C0043204	hp.json	ductus mesonephricus; ductus Wolffi|Leydig's duct|Wolffian duct|renal duct|archinephric duct	http://purl.obolibrary.org/obo/UBERON_0003074		uberon_slim|vertebrate_core|pheno_slim
HP:0003124	biolink:PhenotypicFeature	Hypercholesterolemia	An increased concentration of cholesterol in the blood.	SNOMEDCT_US:166830008|UMLS:C0020443|SNOMEDCT_US:13644009|UMLS:C0595929|MSH:D006937	hp.json	High cholesterol|Increased total cholesterol|Elevated serum cholesterol|Elevated total cholesterol	http://purl.obolibrary.org/obo/HP_0003124		
HP:0030714	biolink:PhenotypicFeature	Subchorionic thrombohematoma	A large maternal clot that separates the chorionic plate from the villous chorion.	UMLS:C1390676	hp.json	Breus' mole	http://purl.obolibrary.org/obo/HP_0030714		
UBERON:0003075	biolink:AnatomicalEntity	neural plate	A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].	XAO:0000249|VHOG:0000068|EHDAA:902|AAO:0011072|UMLS:C0920623|FMA:293879|DMBA:15565|EMAPA:35593|MESH:D054258|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1362|EHDAA:346|RETIRED_EHDAA2:0001252|ZFA:0000132|NCIT:C34225|DHBA:10153|Wikipedia:Neural_plate|BTO:0001765|TAO:0000132	hp.json	lamina neuralis|presumptive central nervous system|lamina neuralis	http://purl.obolibrary.org/obo/UBERON_0003075		uberon_slim|vertebrate_core|pheno_slim
HP:0030715	biolink:PhenotypicFeature	Bronchial atresia	A developmental anomaly characterised by focal obliteration of the proximal segment of a bronchus. The bronchial pattern is entirely normal distal to the site of stenosis.	UMLS:C0265776|SNOMEDCT_US:50513008	hp.json	Congenital bronchial atresia	http://purl.obolibrary.org/obo/HP_0030715		
UBERON:0003072	biolink:AnatomicalEntity	optic cup	Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP].	EHDAA:2912|SCTID:308789007|ZFA:0001202|EMAPA:16674|BTO:0005351|EHDAA2:0001303|TAO:0001202|UMLS:C0231109|NCIT:C34233|VHOG:0000167	hp.json	ophtalmic cup|eyecup|eye cup|ocular cup	http://purl.obolibrary.org/obo/UBERON_0003072		vertebrate_core|pheno_slim
UBERON:0003073	biolink:AnatomicalEntity	lens placode	A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP].	UMLS:C1517770|VHOG:0000166|EFO:0003494|ZFA:0000122|EMAPA:16672|NCIT:C34202|EHDAA2:0000982|XAO:0000240|FMA:296767|TAO:0000122|EHDAA:2908|AAO:0011055|Wikipedia:Lens_placode	hp.json	lens placodes|placoda lentis|placoda lentis	http://purl.obolibrary.org/obo/UBERON_0003073		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0003070	biolink:AnatomicalEntity	trigeminal placode complex	A neurogenic placode that arises at the level of the midbrain-hindbrain boundary and develops into a trigeminal ganglion.	EHDAA2:0004209|VHOG:0000109|ZFA:0000162|TAO:0000162|EFO:0003433|XAO:0000225	hp.json	trigeminal placode|profundus V placode|trigeminal placodes|trigeminal V placode|profundus placode	http://purl.obolibrary.org/obo/UBERON_0003070		efo_slim
HP:0005787	biolink:PhenotypicFeature	Lumbar platyspondyly	A flattened vertebral body shape with reduced distance beween the vertebral endplates affecting the lumbar spine.	UMLS:C4025136	hp.json		http://purl.obolibrary.org/obo/HP_0005787		
HP:0003128	biolink:PhenotypicFeature	Lactic acidosis	An abnormal buildup of lactic acid in the body, leading to acidification of the blood and other bodily fluids.	UMLS:C0347959|UMLS:C0001125|MSH:D000140|SNOMEDCT_US:190882007|SNOMEDCT_US:91273001	hp.json	Lactic acidemia|Lacticacidemia|Lacticacidosis|Hyperlacticacidemia|Increased lactate in body	http://purl.obolibrary.org/obo/HP_0003128		
HP:0030710	biolink:PhenotypicFeature	Lipomeningocele	A form of closed neural tube defect in which the spinal tissue lies within the spinal cord having a junction between the spinal cord and the lipoma. Intact skin covers the defect. Neurologic findings first appear during the second year of life.	UMLS:C0431344|SNOMEDCT_US:253120005	hp.json		http://purl.obolibrary.org/obo/HP_0030710		
HP:0003127	biolink:PhenotypicFeature	Hypocalciuria	An abnormally decreased calcium concentration in the urine.	UMLS:C0020599|SNOMEDCT_US:86353007	hp.json	Low urine calcium levels	http://purl.obolibrary.org/obo/HP_0003127		
UBERON:0003071	biolink:AnatomicalEntity	eye primordium	Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles.	XAO:0004090|AAO:0011038|ZFA:0000570|TAO:0000570|EHDAA2:0004431|EFO:0003541|XAO:0000227	hp.json	optic field|optic placode of camera-type eye|occular primordium|optic placode of camera-type eye|ocular primordium|optic primordium|eye anlage|optic placode|eye field|optic placodes|eye placode	http://purl.obolibrary.org/obo/UBERON_0003071		efo_slim
HP:0005788	biolink:PhenotypicFeature	Abnormal cervical myelogram		UMLS:C4025135	hp.json		http://purl.obolibrary.org/obo/HP_0005788		
HP:0030711	biolink:PhenotypicFeature	Hydrocolpos	Distention of the vagina caused by accumulation of fluid due to congenital vaginal obstruction.	UMLS:C1399870|MSH:D052202	hp.json		http://purl.obolibrary.org/obo/HP_0030711		
HP:0005781	biolink:PhenotypicFeature	Contractures of the large joints		UMLS:C1859698	hp.json		http://purl.obolibrary.org/obo/HP_0005781		
HP:0030716	biolink:PhenotypicFeature	Acrania	Partial or complete absence of the flat bones of the cranial vault. The condition is frequently, though not always, associated with anencephaly.	MSH:D009436|SNOMEDCT_US:203923004|UMLS:C0702169	hp.json		http://purl.obolibrary.org/obo/HP_0030716		
HP:0030717	biolink:PhenotypicFeature	Meconium peritonitis	Peritonitis caused by intrauterine intestinal rupture and spillage of fetal meconium into the fetal peritoneal cavity. Intra-peritoneal meconium usually calcifies, sometimes within 24 hours. Ultrasound findings may include intraabdominal calcifications.	UMLS:C0270250|SNOMEDCT_US:57341009	hp.json		http://purl.obolibrary.org/obo/HP_0030717		
HP:0003121	biolink:PhenotypicFeature	Limb joint contracture	A contracture (chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin) that prevent normal movement of one or more joints of the limbs.	UMLS:C1969879	hp.json	Limb contractures	http://purl.obolibrary.org/obo/HP_0003121		
UBERON:0003078	biolink:AnatomicalEntity	epibranchial placode	Focal thickenings of the embryonic ectoderm that form immediately dorsal and caudal of the clefts between the pharyngeal arches and that produce the neuroblasts that migrate and condense to form the distal cranial ganglia.	TAO:0001294|FMA:293968|XAO:0000284|AAO:0011036|VHOG:0000117|ZFA:0001294|EFO:0003455	hp.json	epibranchial placodes|ventrolateral placode	http://purl.obolibrary.org/obo/UBERON_0003078		efo_slim
HP:0030718	biolink:PhenotypicFeature	Right atrial enlargement	Increase in size of the right atrium.	Fyler:2859|UMLS:C0748427|Fyler:1771|SNOMEDCT_US:67751000119106	hp.json	Right atrial dilatation|Enlarged heart right atrium|Dilated right atrium	http://purl.obolibrary.org/obo/HP_0030718		
HP:0005780	biolink:PhenotypicFeature	Absent fourth finger distal interphalangeal crease	Absence of the distal interphalangeal flexion creases of the fourth finger.	UMLS:C4021621	hp.json	No fourth finger distal interphalangeal crease	http://purl.obolibrary.org/obo/HP_0005780		
HP:0030719	biolink:PhenotypicFeature	Unguarded tricuspid valve	A form of agenesis of the tricuspid valve in which (although the normal orifice between the right atrium and right ventricle exists) there is no tricuspid valvular tissue.	SNOMEDCT_US:253381001|UMLS:C0344745	hp.json	Rudimentary tricuspid valve leaflets|Unguarded tricuspid valve orifice	http://purl.obolibrary.org/obo/HP_0030719		
UBERON:0015043	biolink:AnatomicalEntity	manual digit 1 metacarpus endochondral element	A manual digit 1 metacarpus bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit 1 metacarpus element|manual digit 1 metacarpus skeletal element|manual digit I metacarpus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015043		
UBERON:0015042	biolink:AnatomicalEntity	manual digit metacarpus endochondral element	A manual digit metacarpus bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit metacarpus element|manual digit metacarpus skeletal element	http://purl.obolibrary.org/obo/UBERON_0015042		
UBERON:0015045	biolink:AnatomicalEntity	manual digit 3 metacarpus endochondral element	A manual digit 3 metacarpus bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit III metacarpus endochondral element|manual digit 3 metacarpus element|manual digit 3 metacarpus skeletal element	http://purl.obolibrary.org/obo/UBERON_0015045		
UBERON:0015044	biolink:AnatomicalEntity	manual digit 2 metacarpus endochondral element	A manual digit 2 metacarpus bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit 2 metacarpus element|manual digit 2 metacarpus skeletal element|manual digit II metacarpus endochondral element	http://purl.obolibrary.org/obo/UBERON_0015044		
UBERON:0015041	biolink:AnatomicalEntity	pedal digit 5 metatarsal endochondral element	A pedal digit 5 metatarsal bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit 5 metatarsal skeletal element|pedal digit V metatarsal endochondral element|pedal digit 5 metatarsal element	http://purl.obolibrary.org/obo/UBERON_0015041		
UBERON:0015040	biolink:AnatomicalEntity	pedal digit 4 metatarsal endochondral element	A pedal digit 4 metatarsal bone or its cartilage or pre-cartilage precursor.		hp.json	pedal digit IV metatarsal endochondral element|pedal digit 4 metatarsal skeletal element|pedal digit 4 metatarsal element	http://purl.obolibrary.org/obo/UBERON_0015040		
UBERON:0015047	biolink:AnatomicalEntity	manual digit 5 metacarpus endochondral element	A manual digit 5 metacarpus bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit V metacarpus endochondral element|manual digit 5 metacarpus skeletal element|manual digit 5 metacarpus element	http://purl.obolibrary.org/obo/UBERON_0015047		
UBERON:0015046	biolink:AnatomicalEntity	manual digit 4 metacarpus endochondral element	A manual digit 4 metacarpus bone or its cartilage or pre-cartilage precursor.		hp.json	manual digit IV metacarpus endochondral element|manual digit 4 metacarpus element|manual digit 4 metacarpus skeletal element	http://purl.obolibrary.org/obo/UBERON_0015046		
UBERON:0015049	biolink:AnatomicalEntity	carpus endochondral element	A carpus bone or its cartilage or pre-cartilage precursor.		hp.json	carpus skeletal element|carpus element	http://purl.obolibrary.org/obo/UBERON_0015049		
HP:0030723	biolink:PhenotypicFeature	Congenital megalourethra	Dilation and elongation of the penile urethra associated with absence or hypoplasia of the corpora spongiosa and cavernosa.	UMLS:C4280800	hp.json		http://purl.obolibrary.org/obo/HP_0030723		
HP:0003137	biolink:PhenotypicFeature	Prolinuria	An increased concentration of proline in the urine.	UMLS:C0268534|SNOMEDCT_US:53124003	hp.json		http://purl.obolibrary.org/obo/HP_0003137		
HP:0030724	biolink:PhenotypicFeature	Central nervous system cyst	A fluid-filled sac (cyst) located within the central nervous system.	UMLS:C0349606|MSH:D020863|SNOMEDCT_US:277333006	hp.json	CNS cyst|Cyst of the central nervous system	http://purl.obolibrary.org/obo/HP_0030724		
UBERON:0003066	biolink:AnatomicalEntity	pharyngeal arch 2	The second pharyngeal arch will form the hyoid apparatus. The cranial neural crest cells that populate the second pharyngeal arch emerge primarily from rhombomere 4 and will form skeletal elements.	EHDAA2:0000050|ZFA:0001611|VHOG:0000297|EHDAA:611|XAO:0000098|SCTID:308768003|FMA:293017|TAO:0001596|EMAPA:16272|NCIT:C34288|AAO:0010363|Wikipedia:Second_pharyngeal_arch	hp.json	branchial arch 2|arcus pharyngeus secundus|hyoid arch|second pharyngeal arch|hyoid bars|arcus pharyngeus secundus|pharyngeal arch 2|2nd visceral arch|second branchial arch|second visceral arch|visceral arch 2|pharyngeal arches 2|2nd arch|2nd pharyngeal arch	http://purl.obolibrary.org/obo/UBERON_0003066		uberon_slim|vertebrate_core|pheno_slim
UBERON:0003063	biolink:AnatomicalEntity	prechordal plate	A horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue.	EHDAA2:0001493|AAO:0011085|TAO:0000060|EHDAA:181|XAO:0000079|VHOG:0000086|Wikipedia:Prechordal_plate|FMA:295532|ZFA:0000060	hp.json	head mesenchyme|head mesoderm	http://purl.obolibrary.org/obo/UBERON_0003063		uberon_slim|vertebrate_core|pheno_slim
HP:0030725	biolink:PhenotypicFeature	Neurenteric cyst	The neurenteric cyst is a rare lesion composed of heterotopic endodermal tissue. During the third week of human embryogenesis, the neurenteric canal unites the yolk sac and the amniotic cavity as it traverses the primitive notochordal plate. Persistence of the normally transient neurenteric canal prevents appropriate separation of endoderm and notochord. This results in a variable degree of communication between neural and enteric epithelium.	SNOMEDCT_US:253127008|MSH:D009436|SNOMEDCT_US:41353005|UMLS:C0027806	hp.json		http://purl.obolibrary.org/obo/HP_0030725		
UBERON:0003064	biolink:AnatomicalEntity	intermediate mesoderm	The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads.	Wikipedia:Intermediate_mesoderm|ZFA:0001206|NCIT:C34193|SCTID:361476001|VHOG:0000087|TAO:0001206|EMAPA:16178|EMAPA:16056|XAO:0000085|AAO:0010575|UMLS:C1284010|FMA:293147	hp.json	intermediate mesenchyme|intermediate plate mesoderm|mesenchyma intermedium|intermediate mesenchyme|intermediate plate|IM|intermediate plate mesoderm|mesenchyma intermedium	http://purl.obolibrary.org/obo/UBERON_0003064		uberon_slim|vertebrate_core|pheno_slim
HP:0030726	biolink:PhenotypicFeature	Spinal neurenteric cyst	A neurenteric cyst located in the spine.	UMLS:C4280799	hp.json		http://purl.obolibrary.org/obo/HP_0030726		
HP:0003134	biolink:PhenotypicFeature	Abnormality of peripheral nerve conduction	An abnormality of the conduction of electrical impulses by peripheral (motor or sensory) nerves. This finding is elicited by a nerve conduction study (NCS).	UMLS:C4020690	hp.json	Sensory and motor nerve conduction abnormalities|Abnormal peripheral nerve transmission	http://purl.obolibrary.org/obo/HP_0003134		
UBERON:0003061	biolink:AnatomicalEntity	blood island	Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted].	TAO:0000094|EHDAA:207|VHOG:0000085|XAO:0000067|AAO:0011006|UMLS:C1511224|NCIT:C34113|EFO:0003489|ZFA:0000094|TE:E5.11.2.0.0.0.4|Wikipedia:Blood_island_of_umbilical_vesicle	hp.json	caudal hematopoietic tissue|ventral lateral plate mesoderm|blood islands|ventral blood island|posterior ICM|VBI|posterior blood island	http://purl.obolibrary.org/obo/UBERON_0003061		uberon_slim|vertebrate_core|pheno_slim|efo_slim
HP:0030720	biolink:PhenotypicFeature	Subchorionic septal cyst	Cyst on the surface of the placenta consisting of amnion and chorion.	UMLS:C4280801	hp.json		http://purl.obolibrary.org/obo/HP_0030720		
HP:0003139	biolink:PhenotypicFeature	Panhypogammaglobulinemia	A reduction in the circulating levels of all the major classes of immunoglobulin. is characterized by profound decreases in all classes of immunoglobulin with an absence of circulating B lymphocytes.	UMLS:C1328587	hp.json	Panypogammaglobulinemia|Panhypogammaglobulinaemia	http://purl.obolibrary.org/obo/HP_0003139		
HP:0030721	biolink:PhenotypicFeature	Tetraphocomelia	Phocomelia involving all four extremities.	UMLS:C1849370	hp.json		http://purl.obolibrary.org/obo/HP_0030721		
HP:0005798	biolink:PhenotypicFeature	Posterior radial head dislocation	A dislocation of the head of the radius from its socket in the elbow joint in an posterior direction.	MSH:C566728|UMLS:C1867398	hp.json		http://purl.obolibrary.org/obo/HP_0005798		
UBERON:0003060	biolink:AnatomicalEntity	pronephric duct	In mammals, the pronephric duct is the predecessor of the Wolffian duct[WP].	NCIT:C34279|VHOG:0000082|UMLS:C1283945|XAO:0000063|ZFA:0000150|AAO:0011088|TAO:0000150	hp.json	pronephric ducts|ductus pronephricus|archinephric duct	http://purl.obolibrary.org/obo/UBERON_0003060		uberon_slim
HP:0030722	biolink:PhenotypicFeature	Ectopic liver	Ectopic liver is a rare developmental anomaly in which liver tissue is situated outside the liver. Thus, ectopic liver refers to autonomous islands of normal liver parenchyma located outside the liver. The term ectopic liver is also used, to include liver appendices attached to the native liver by a thin stalk although being fully separated from the latter.	SNOMEDCT_US:253813000|UMLS:C0431603	hp.json		http://purl.obolibrary.org/obo/HP_0030722		
HP:0003138	biolink:PhenotypicFeature	Increased blood urea nitrogen	An increased amount of nitrogen in the form of urea in the blood.	UMLS:C0151539	hp.json	Increased BUN|Increased blood urea nitrogen	http://purl.obolibrary.org/obo/HP_0003138		
HP:0005792	biolink:PhenotypicFeature	Short humerus	Underdevelopment of the humerus.	UMLS:C1832117	hp.json	Hypoplastic humerus|Short long bone of upper arm|Humeral shortening|Short humeri|Short upper arms|Humeral hypoplasia|Short humerus	http://purl.obolibrary.org/obo/HP_0005792		hposlim_core
HP:0005793	biolink:PhenotypicFeature	Shortening of all distal phalanges of the toes	Abnormally short distal phalanx of toe of all toes.	UMLS:C4025132	hp.json	Shortening of all outermost bone of the toes	http://purl.obolibrary.org/obo/HP_0005793		
HP:0005794	biolink:PhenotypicFeature	obsolete Arterial disease of legs			hp.json		http://purl.obolibrary.org/obo/HP_0005794		
UBERON:0003069	biolink:AnatomicalEntity	otic placode	A cranial placode which, once specified, invaginates to form an otic cup, which eventually separates from the surface ectoderm to form the otic vesicle or otocyst, a rounded structure without appar- ent polarity. As the otic placode invaginates into a cup neuroblasts delaminate from the anterior ventral aspect of the otic epithelium to give rise to neurons of the vestibulocochlear (statoacoustic) ganglion of cranial nerve VIII[NBK].	UMLS:C1518677|VHOG:0000235|EHDAA:506|ZFA:0000138|EHDAA2:0001339|XAO:0000223|TAO:0000138|NCIT:C34239|EFO:0003429|FMA:293973|EMAPA:16195|AAO:0011079	hp.json	auditory placode|octaval VIII placode|ear/otic placode|placoda otica|ear placode|octaval placode	http://purl.obolibrary.org/obo/UBERON_0003069		efo_slim|uberon_slim|vertebrate_core|pheno_slim
HP:0030727	biolink:PhenotypicFeature	Intracranial neurenteric cyst	A neurenteric cyst located within the skull.	UMLS:C4280680	hp.json		http://purl.obolibrary.org/obo/HP_0030727		
HP:0003133	biolink:PhenotypicFeature	Abnormality of the spinocerebellar tracts	An abnormality of the spinocerebellar tracts, a set of axonal fibers originating in the spinal cord and terminating in the ipsilateral cerebellum. The spinocerebellar tract convey information to the cerebellum about limb and joint position (proprioception). They comprise the ventral spinocerebellar tract, the anterior spinocerebellar tract, and the posterior spinocerebellar tract.	UMLS:C4025647	hp.json		http://purl.obolibrary.org/obo/HP_0003133		
HP:0030728	biolink:PhenotypicFeature	Meromelia	Partial absence of a free limb (excluding girdle). It can refer to the proximal, middle or distal segment of the upper or lower limb. The deficiency may be transverse or longitudinal. Thus, meromelia is a lack of a part, but not all, of one or more limbs with the presence of a hand or foot.	UMLS:C0265549|SNOMEDCT_US:60220000	hp.json		http://purl.obolibrary.org/obo/HP_0030728		
HP:0005790	biolink:PhenotypicFeature	Short mandibular condyles		UMLS:C4280475|UMLS:C4280474|UMLS:C4025134	hp.json	Short condylar head of mandible|Short condylar neck of mandible|Short condylar process of mandible|Bilateral hypoplasia of condylar process of mandible|Bilateral hypoplasia of mandibular condylar head|Bilateral hypoplasia of mandibular condylar neck|Decreased height of condylar process of mandible|Decreased length of condylar process of mandible	http://purl.obolibrary.org/obo/HP_0005790		
HP:0030729	biolink:PhenotypicFeature	Frontoethmoidal meningocele	A herniation of meninges through a congenital bone defect in the skull at the junction of the frontal and ethmoidal bones.	UMLS:C4280798	hp.json	Frontoethmoid meningocele	http://purl.obolibrary.org/obo/HP_0030729		
UBERON:0003067	biolink:AnatomicalEntity	dorsolateral placode	Lateral neurogenic placodes positioned dorsal of the epibranchial placodes.	VHOG:0000103|ZFA:0001310|XAO:0000187|TAO:0001310	hp.json	dorsolateral placodes	http://purl.obolibrary.org/obo/UBERON_0003067		
HP:0003131	biolink:PhenotypicFeature	Cystinuria	An increased concentration of cystine in the urine.	UMLS:C0010691|SNOMEDCT_US:85020001|MSH:D003555	hp.json	High urine cystine levels	http://purl.obolibrary.org/obo/HP_0003131		
UBERON:0003068	biolink:AnatomicalEntity	axial mesoderm	The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.	XAO:0000205|ZFA:0001204|TAO:0001204|AAO:0011017|EFO:0003647|VHOG:0000107|Wikipedia:Chordamesoderm	hp.json	chordamesoderm|chordamesoderm	http://purl.obolibrary.org/obo/UBERON_0003068		efo_slim|uberon_slim
HP:0003130	biolink:PhenotypicFeature	Abnormal peripheral myelination	An abnormality of the myelination of motor and sensory peripheral nerves. These are axons for motor nerves and dendrites for sensory nerves in the strict anatomic sense.	UMLS:C4025648	hp.json		http://purl.obolibrary.org/obo/HP_0003130		
HP:0005791	biolink:PhenotypicFeature	Cortical thickening of long bone diaphyses	Abnormal thickening of the cortex of the diaphyseal region of long bones.	UMLS:C4025133	hp.json		http://purl.obolibrary.org/obo/HP_0005791		
UBERON:0005629	biolink:AnatomicalEntity	vascular plexus	A vascular network formed by frequent anastomoses between the blood vessels (arteries or veins) of a part.	EHDAA2:0004112|FMA:5900|AEO:0000219|EMAPA:35904|XAO:0004143	hp.json	plexus vasculosus	http://purl.obolibrary.org/obo/UBERON_0005629		
UBERON:0017615	biolink:AnatomicalEntity	vomerine dentition	A set of teeth in which each tooth that attaches to a vomer.	AAO:0000635	hp.json	vomerine teeth	http://purl.obolibrary.org/obo/UBERON_0017615		
UBERON:0005637	biolink:AnatomicalEntity	pyloric region epithelium	An epithelium that is part of a pylorus.	EHDAA2:0001582|EMAPA:17633|RETIRED_EHDAA2:0001927	hp.json		http://purl.obolibrary.org/obo/UBERON_0005637		
UBERON:0005631	biolink:AnatomicalEntity	extraembryonic membrane	Intrinsic membrane that arises from embryonic germ layers and grow to surround the developing embryo.	EHDAA2:0004714|SCTID:362840007|FMA:305915|MESH:D005321	hp.json		http://purl.obolibrary.org/obo/UBERON_0005631		
CHEBI:46662	biolink:ChemicalSubstance	mineral			hp.json		http://purl.obolibrary.org/obo/CHEBI_46662		
UBERON:0005619	biolink:AnatomicalEntity	secondary palatal shelf	The outgrowths of the embryonic maxillary prominences that come together during prenatal development to form the secondary palate.	EMAPA:17362|EHDAA2:0001364|MA:0001581|VHOG:0000378|FMA:295948|EHDAA:9283	hp.json	secondary palatal shelf|palatine shelf|palatal shelves|lateral palatine process|palatal shelf	http://purl.obolibrary.org/obo/UBERON_0005619		pheno_slim
UBERON:0005617	biolink:AnatomicalEntity	mesenteric vein	A vein that returns blood from the intestines.	EHDAA:4442|MESH:D008642|SCTID:304045008|BTO:0002781|EMAPA:17348|RETIRED_EHDAA2:0001125|UMLS:C0025473|NCIT:C53055|Wikipedia:Mesenteric_vein|MA:0002177	hp.json	intestinal vein|intestinal vein	http://purl.obolibrary.org/obo/UBERON_0005617		
UBERON:0005616	biolink:AnatomicalEntity	mesenteric artery	Arteries which arise from the abdominal aorta and distribute to most of the intestines.	XAO:0000370|EHDAA2:0001123|EHDAA:4343|SCTID:281084003|VHOG:0001117|NCIT:C52975|EMAPA:17312|Wikipedia:Mesenteric_artery|BTO:0000779|UMLS:C0025465|MA:0002003|MESH:D008638	hp.json		http://purl.obolibrary.org/obo/UBERON_0005616		
UBERON:0005626	biolink:AnatomicalEntity	ventral mesogastrium	Portion of ventral mesentery closest to the stomach.	EHDAA2:0002176|TAO:0005133|VHOG:0000351|EMAPA:17026|MA:0001621|NCIT:C34327|UMLS:C1519967|EHDAA:3005|ZFA:0005133	hp.json	foregut ventral mesentery	http://purl.obolibrary.org/obo/UBERON_0005626		vertebrate_core
UBERON:0005625	biolink:AnatomicalEntity	tubotympanic recess lumen	The cavity formed by the tubotympanic recess epithelium.	EHDAA2:0002095|FMA:312393	hp.json	tubotympanic recess|tubotympanic recess space|tubotympanic recess cavity|cavity of tubotympanic recess	http://purl.obolibrary.org/obo/UBERON_0005625		
UBERON:0005624	biolink:AnatomicalEntity	suprarenal artery	Artery that supplies blood to the adrenal glands.	EMAPA:37124|MA:0001914|EHDAA:8596|EHDAA2:0001965|ncithesaurus:Adrenal_Artery|NCIT:C33708	hp.json	adrenal artery	http://purl.obolibrary.org/obo/UBERON_0005624		grouping_class
UBERON:0005623	biolink:AnatomicalEntity	semi-lunar valve	The valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk.	EHDAA:4408|EMAPA:35760|EHDAA2:0001823|VHOG:0001393|MA:0002790	hp.json	semilunar valve|semilunar valves	http://purl.obolibrary.org/obo/UBERON_0005623		pheno_slim
UBERON:0005622	biolink:AnatomicalEntity	right dorsal aorta		EMAPA:16206|EHDAA:406|VHOG:0000485|MA:0000479|SCTID:361404004|EHDAA2:0001720	hp.json		http://purl.obolibrary.org/obo/UBERON_0005622		
UBERON:0005620	biolink:AnatomicalEntity	primary palate	The part of the palate formed from the intermaxillary segment.	VHOG:0000362|UMLS:C1268540|EMAPA:17642|EHDAA2:0001499|MA:0001583|EHDAA2:0001496|FMA:295874|NCIT:C34264	hp.json	primary palate|processus palatinus medianus|primitive palate|primary palate process|palatum primarium	http://purl.obolibrary.org/obo/UBERON_0005620		vertebrate_core|pheno_slim
UBERON:0005609	biolink:AnatomicalEntity	iliac artery	Any of the arteries that arise from a bifurcation of the aorta supplying the pelvic or abdomen. Examples: Common iliac artery, External iliac artery, Internal iliac artery.	MESH:D007083|XAO:0000361|EHDAA:2551|EMAPA:17309|BTO:0004665|galen:IliacArtery|NCIT:C12733|UMLS:C0020887|MA:0001971|RETIRED_EHDAA2:0000807	hp.json		http://purl.obolibrary.org/obo/UBERON_0005609		grouping_class
GO:0006403	biolink:BiologicalProcess	RNA localization	A process in which RNA is transported to, or maintained in, a specific location.		hp.json	establishment and maintenance of RNA localization|RNA localisation	http://purl.obolibrary.org/obo/GO_0006403		goslim_drosophila
UBERON:0005606	biolink:AnatomicalEntity	hyaloid cavity		MA:0000272|FMA:312291|VHOG:0001477|EHDAA2:0000789|EMAPA:17302|EHDAA:4733	hp.json		http://purl.obolibrary.org/obo/UBERON_0005606		
UBERON:0005614	biolink:AnatomicalEntity	lens anterior epithelium	A layer of cuboidal epithelial cells bounded anteriorly by the capsule of the lens and posteriorly by the lens cortex.	VHOG:0001425|RETIRED_EHDAA2:0000976|EHDAA:9059|EMAPA:17304|MA:0001302|FMA:70612|EHDAA2:0000984|NCIT:C33641|UMLS:C1182652|SCTID:362521008|EMAPA:17839	hp.json	lens subcapsular epithelium|subcapsular lens epithelium|lens subcapsular epithelium|anterior surface of lens|lens epithelium|anterior epithelium of lens vesicle	http://purl.obolibrary.org/obo/UBERON_0005614		
UBERON:0005613	biolink:AnatomicalEntity	left dorsal aorta		EHDAA2:0000936|EMAPA:16205|SCTID:361403005|VHOG:0000484|EHDAA:404|MA:0000478	hp.json		http://purl.obolibrary.org/obo/UBERON_0005613		
UBERON:0005611	biolink:AnatomicalEntity	inner canthus	A corner of the medial (inner) part of an eye.	EHDAA2:0000829|NCIT:C49564|FMA:59316|UMLS:C1708516|EMAPA:17830|VHOG:0000829|MA:0001262	hp.json	medial palpebral commissure|inner canthi|medial canthus|medial canthus of eye|nasal canthus	http://purl.obolibrary.org/obo/UBERON_0005611		
UBERON:0005610	biolink:AnatomicalEntity	iliac vein	Any of the three veins including the common, external and internal iliac veins.	UMLS:C0020888|EMAPA:37151|EHDAA2:0000811|NCIT:C12734|MESH:D007084|MA:0002142	hp.json	pelvic vein	http://purl.obolibrary.org/obo/UBERON_0005610		
CHEBI:22695	biolink:ChemicalSubstance	base	A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base).	KEGG:C00701	hp.json	Basen|Base2|Base1|base|Base|Nucleobase|base|bases	http://purl.obolibrary.org/obo/CHEBI_22695		3_STAR
GO:0006417	biolink:BiologicalProcess	regulation of translation	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.		hp.json	regulation of protein biosynthesis|regulation of protein anabolism|regulation of protein synthesis|regulation of protein formation	http://purl.obolibrary.org/obo/GO_0006417		goslim_yeast
GO:0006414	biolink:BiologicalProcess	translational elongation	The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.		hp.json	translation elongation|protein synthesis elongation	http://purl.obolibrary.org/obo/GO_0006414		goslim_yeast
GO:0006415	biolink:BiologicalProcess	translational termination	The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).		hp.json	translation termination|protein synthesis termination|translational complex disassembly	http://purl.obolibrary.org/obo/GO_0006415		
GO:0006412	biolink:BiologicalProcess	translation	The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.	Wikipedia:Translation_(genetics)	hp.json	protein anabolism|protein biosynthetic process|protein biosynthesis|protein synthesis|protein formation|protein translation	http://purl.obolibrary.org/obo/GO_0006412		goslim_candida|goslim_plant|goslim_pir|goslim_drosophila|goslim_aspergillus|goslim_chembl|goslim_metagenomics
GO:0006413	biolink:BiologicalProcess	translational initiation	The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.		hp.json	translation initiation|biopolymerisation|protein synthesis initiation|biopolymerization	http://purl.obolibrary.org/obo/GO_0006413		goslim_yeast
UBERON:0005604	biolink:AnatomicalEntity	extrahepatic part of hepatic duct		VHOG:0000215|EMAPA:16844|MA:0001636	hp.json	extrahepatic part of the hepatic duct|hepatic duct extrahepatic part	http://purl.obolibrary.org/obo/UBERON_0005604		
UBERON:0029636	biolink:AnatomicalEntity	lumbar spinal cord gray matter		BIRNLEX:1624	hp.json	lumbar spinal cord gray matter|lumbar spinal cord gray matter	http://purl.obolibrary.org/obo/UBERON_0029636		
UBERON:0005602	biolink:AnatomicalEntity	dorsal mesogastrium	The portion of mesentery attached to the greater curvature of the stomach is named the dorsal mesentery (or dorsal mesogastrium, when referring to the portion at the stomach), and the part which suspends the colon is termed the mesocolon. The dorsal mesogastrium develops into the greater omentum.	EHDAA:3001|MA:0001618|UMLS:C1512038|NCIT:C34142|EHDAA2:0000416|VHOG:0000352|EMAPA:17025	hp.json	dorsal mesentery	http://purl.obolibrary.org/obo/UBERON_0005602		
UBERON:0017651	biolink:AnatomicalEntity	salivary gland primordium	A primordium that has the potential to develop into a saliva-secreting gland.		hp.json		http://purl.obolibrary.org/obo/UBERON_0017651		
CHEBI:22660	biolink:ChemicalSubstance	aspartic acid	An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent	CAS:617-45-8|Gmelin:185140|PMID:22264337|CAS:617-45-8|CAS:617-45-8|Beilstein:774618|KEGG:C16433|Reaxys:774618|Wikipedia:Aspartic_acid	hp.json	aspartic acid|Asp|(R,S)-Aspartic acid|Aspartic acid|DL-Asparagic acid|DL-Aminosuccinic acid|(+-)-Aspartic acid|D|2-aminobutanedioic acid	http://purl.obolibrary.org/obo/CHEBI_22660		3_STAR
UBERON:0017650	biolink:AnatomicalEntity	developing mesenchymal structure	A mesenchyme-derived anatomical entity undergoing a transtion to become another structure.	AEO:0001016	hp.json		http://purl.obolibrary.org/obo/UBERON_0017650		
UBERON:0017659	biolink:AnatomicalEntity	ventral surface of penis		FMA:19624	hp.json	urethral surface of penis	http://purl.obolibrary.org/obo/UBERON_0017659		pheno_slim
UBERON:0017654	biolink:AnatomicalEntity	buccal gland	Any of the small racemose mucous glands in the mucous membrane lining the cheeks.	BTO:0005767	hp.json	cheek gland	http://purl.obolibrary.org/obo/UBERON_0017654		
UBERON:0005673	biolink:AnatomicalEntity	left lung endothelium	An endothelium that is part of a left lung.	EHDAA2:0000961	hp.json		http://purl.obolibrary.org/obo/UBERON_0005673		
HP:0005723	biolink:PhenotypicFeature	Shoe-shaped sella turcica		UMLS:C4025147	hp.json		http://purl.obolibrary.org/obo/HP_0005723		
UBERON:0005672	biolink:AnatomicalEntity	right lung endothelium	An endothelium that is part of a right lung.	EHDAA2:0001755	hp.json		http://purl.obolibrary.org/obo/UBERON_0005672		
HP:0005725	biolink:PhenotypicFeature	Nonopposable triphalangeal thumb	A form of triphalangeal thumb that cannot be placed opposite the fingers of the same hand.	MSH:C536562|UMLS:C2931238	hp.json		http://purl.obolibrary.org/obo/HP_0005725		
HP:0005726	biolink:PhenotypicFeature	Thumbs hypoplastic with bulbous tips		UMLS:C4025146	hp.json	Short thumbs with bulbous tips	http://purl.obolibrary.org/obo/HP_0005726		
HP:0005720	biolink:PhenotypicFeature	Shortening of all metacarpals	Abnormal reduction in length of all metacarpal bones.	UMLS:C4025149	hp.json		http://purl.obolibrary.org/obo/HP_0005720		
HP:0005722	biolink:PhenotypicFeature	Hyperextensible thumb	The ability of the thumb joints to move beyond their normal range of motion.	UMLS:C4025148	hp.json	Double jointed thumb	http://purl.obolibrary.org/obo/HP_0005722		
CHEBI:22676	biolink:ChemicalSubstance	auxin	Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").	Wikipedia:Auxin	hp.json	auxins	http://purl.obolibrary.org/obo/CHEBI_22676		3_STAR
UBERON:0017648	biolink:AnatomicalEntity	ventral body wall	The ventral part of the body wall.	FMA:86934|EMAPA:37984	hp.json	anterior body wall	http://purl.obolibrary.org/obo/UBERON_0017648		
UBERON:0017649	biolink:AnatomicalEntity	dorsal body wall	The dorsal part of the body wall.		hp.json		http://purl.obolibrary.org/obo/UBERON_0017649		
HP:0005739	biolink:PhenotypicFeature	Posterior subluxation of radial head	Partial dislocation of the head of the radius in the posterior direction.	UMLS:C3149878	hp.json		http://purl.obolibrary.org/obo/HP_0005739		
UBERON:0005662	biolink:AnatomicalEntity	4th arch ectoderm	An ectoderm that is part of a pharyngeal arch 4.	VHOG:0001095|RETIRED_EHDAA2:0000094|EMAPA:16768|EHDAA2:0004032|EMAPA:16764|EMAPA:16762	hp.json	4th pharyngeal arch ectoderm	http://purl.obolibrary.org/obo/UBERON_0005662		
UBERON:0005661	biolink:AnatomicalEntity	3rd arch ectoderm	An ectoderm that is part of a pharyngeal arch 3.	EMAPA:16584|VHOG:0000946|EMAPA:16582|EHDAA2:0000072|RETIRED_EHDAA2:0000079|EMAPA:16400	hp.json	3rd pharyngeal arch ectoderm	http://purl.obolibrary.org/obo/UBERON_0005661		
HP:0005736	biolink:PhenotypicFeature	Short tibia	Underdevelopment (reduced size) of the tibia.	UMLS:C1855277|UMLS:C1850259	hp.json	Shortening of the shankbone|Hypoplasia of the tibia|Hypoplastic tibia|Short tibiae|Shortening of the shinbone|Shortening of the tibia|Short skankbone|Short shinbone	http://purl.obolibrary.org/obo/HP_0005736		
UBERON:0005660	biolink:AnatomicalEntity	2nd arch ectoderm	An ectoderm that is part of a pharyngeal arch 2.	EMAPA:16397|RETIRED_EHDAA2:0000064|VHOG:0001062|EHDAA2:0000055|EMAPA:16398|EMAPA:16277	hp.json	2nd pharyngeal arch ectoderm	http://purl.obolibrary.org/obo/UBERON_0005660		
HP:0005731	biolink:PhenotypicFeature	Cortical irregularity	An abnormal irregularity of cortical bone.	UMLS:C4025145	hp.json		http://purl.obolibrary.org/obo/HP_0005731		
HP:0005733	biolink:PhenotypicFeature	Spinal stenosis with reduced interpedicular distance	An abnormal narrowing of the spinal canal related to a reduction in the interpedicular distance (i.e., the distance measured between the pedicles on frontal [coronal] imaging).	UMLS:C4021625	hp.json	Spinal stenosis due to short pedicles	http://purl.obolibrary.org/obo/HP_0005733		
UBERON:0005669	biolink:AnatomicalEntity	peritoneal cavity mesothelium	A mesothelium that is part of a peritoneal cavity.	FMA:18147|EHDAA2:0001447|SCTID:34073007|EMAPA:16139|BTO:0003156	hp.json	mesothelium of peritoneal component|peritoneum|peritoneum mesothelium|peritoneal mesothelium|peritoneal mesothelium|mesothelium of peritoneum	http://purl.obolibrary.org/obo/UBERON_0005669		
CHEBI:46629	biolink:ChemicalSubstance	oxo group		PDBeChem:O	hp.json	oxo|=O|OXO GROUP	http://purl.obolibrary.org/obo/CHEBI_46629		3_STAR
UBERON:0005667	biolink:AnatomicalEntity	connecting stalk mesoderm		EHDAA2:0000314	hp.json		http://purl.obolibrary.org/obo/UBERON_0005667		
UBERON:0005666	biolink:AnatomicalEntity	4th arch endoderm	An endoderm that is part of a pharyngeal arch 4.	RETIRED_EHDAA2:0000095|VHOG:0001092|EMAPA:16769|EHDAA2:0004033|EMAPA:16767|EMAPA:16765	hp.json	4th pharyngeal arch endoderm	http://purl.obolibrary.org/obo/UBERON_0005666		
UBERON:0005665	biolink:AnatomicalEntity	3rd arch endoderm	An endoderm that is part of a pharyngeal arch 3.	EMAPA:16585|VHOG:0001081|RETIRED_EHDAA2:0000080|EHDAA2:0000075|EMAPA:16401|EMAPA:16587	hp.json	3rd pharyngeal arch endoderm	http://purl.obolibrary.org/obo/UBERON_0005665		
UBERON:0005664	biolink:AnatomicalEntity	2nd arch endoderm	An endoderm that is part of a pharyngeal arch 2.	EMAPA:16278|RETIRED_EHDAA2:0000065|EMAPA:16276|EMAPA:16274|VHOG:0001108|EHDAA2:0000061	hp.json	2nd pharyngeal arch endoderm	http://purl.obolibrary.org/obo/UBERON_0005664		
UBERON:0005649	biolink:AnatomicalEntity	pedal digit 2 epithelium	An epithelium that is part of a pedal digit 2.	EHDAA2:0002043|EMAPA:17464	hp.json	hind limb digit 2 epithelium|pedal digit II epithelium|foot digit 2 epithelium	http://purl.obolibrary.org/obo/UBERON_0005649		
HP:0005709	biolink:PhenotypicFeature	2-3 toe cutaneous syndactyly		UMLS:C0432040|SNOMEDCT_US:205145001	hp.json	Complete cutaneous syndactyly of second and third toes|Webbed skin of 2nd-3rd toes|Cutaneous 2,3 toe syndactyly|Cutaneous syndactyly of second and third toes	http://purl.obolibrary.org/obo/HP_0005709		
UBERON:0017635	biolink:AnatomicalEntity	paired venous dural sinus		FMA:52568	hp.json	paired dural venous sinus	http://purl.obolibrary.org/obo/UBERON_0017635		
HP:0005707	biolink:PhenotypicFeature	Bilateral triphalangeal thumbs	A bilateral form of triphalangeal thumb.	UMLS:C4021627	hp.json	Bilateral digitalized thumb	http://purl.obolibrary.org/obo/HP_0005707		
UBERON:0005651	biolink:AnatomicalEntity	pedal digit 4 epithelium	An epithelium that is part of a pedal digit 4.	EMAPA:17470|EHDAA2:0002053	hp.json	pedal digit IV epithelium|hind limb digit 4 epithelium|foot digit 4 epithelium	http://purl.obolibrary.org/obo/UBERON_0005651		
HP:0005701	biolink:PhenotypicFeature	Multiple enchondromatosis		SNOMEDCT_US:268274005|UMLS:C0014084|MSH:D004687	hp.json		http://purl.obolibrary.org/obo/HP_0005701		
UBERON:0005650	biolink:AnatomicalEntity	pedal digit 3 epithelium	An epithelium that is part of a pedal digit 3.	EHDAA2:0002048|EMAPA:17467	hp.json	hind limb digit 3 epithelium|foot digit 3 epithelium|pedal digit III epithelium	http://purl.obolibrary.org/obo/UBERON_0005650		
HP:0005700	biolink:PhenotypicFeature	Increased bone density with cystic changes		UMLS:C4025151	hp.json		http://purl.obolibrary.org/obo/HP_0005700		
UBERON:0005659	biolink:AnatomicalEntity	primary palate epithelium	An epithelium that is part of a primary palate.	VHOG:0001025|EMAPA:17643|EHDAA2:0001500|FMA:313406	hp.json		http://purl.obolibrary.org/obo/UBERON_0005659		
UBERON:0005658	biolink:AnatomicalEntity	secondary palatal shelf epithelium	An epithelium that is part of a secondary palatal shelf.	FMA:312465|VHOG:0001040|EMAPA:17363|EHDAA2:0001365	hp.json	palatal shelf epithelium	http://purl.obolibrary.org/obo/UBERON_0005658		
UBERON:0005656	biolink:AnatomicalEntity	lens vesicle epithelium	An epithelium that is part of a lens vesicle.	EHDAA2:0000987|EMAPA:17165|VHOG:0000532	hp.json		http://purl.obolibrary.org/obo/UBERON_0005656		
UBERON:0005654	biolink:AnatomicalEntity	lower jaw molar epithelium	A dental epithelium that is part of a lower jaw molar.	EHDAA2:0001026|EMAPA:17922	hp.json		http://purl.obolibrary.org/obo/UBERON_0005654		
UBERON:0005653	biolink:AnatomicalEntity	upper jaw molar epithelium	A dental epithelium that is part of a upper jaw molar.	EHDAA2:0002126|EMAPA:17943	hp.json		http://purl.obolibrary.org/obo/UBERON_0005653		
UBERON:0005652	biolink:AnatomicalEntity	pedal digit 5 epithelium	An epithelium that is part of a pedal digit 5.	EMAPA:17473|EHDAA2:0002058	hp.json	hind limb digit 5 epithelium|pedal digit V epithelium|foot digit 5 epithelium	http://purl.obolibrary.org/obo/UBERON_0005652		
CHEBI:22653	biolink:ChemicalSubstance	asparagine	An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 2-amino-2-oxoethyl group.	Beilstein:1723525|Reaxys:1723525|CAS:3130-87-8|Gmelin:279043|PMID:22264337|KEGG:C16438|PMID:22770225|Wikipedia:Asparagine	hp.json	N|2,4-diamino-4-oxobutanoic acid|asparagine|ASN|Asn|Asparagin|2-amino-3-carbamoylpropanoic acid|DL-Asparagine|Hasp|asparagina	http://purl.obolibrary.org/obo/CHEBI_22653		3_STAR
UBERON:0005638	biolink:AnatomicalEntity	anterior chamber epithelium	An epithelium that is part of a anterior chamber of eyeball.	EHDAA2:0000130	hp.json		http://purl.obolibrary.org/obo/UBERON_0005638		
HP:0005716	biolink:PhenotypicFeature	Lethal skeletal dysplasia		UMLS:C4021626	hp.json	Lethal dwarfism identifiable at birth	http://purl.obolibrary.org/obo/HP_0005716		
HP:0005715	biolink:PhenotypicFeature	Flattened knee epiphyses		UMLS:C4025150	hp.json	Flattened end part of knee bone	http://purl.obolibrary.org/obo/HP_0005715		
UBERON:0005648	biolink:AnatomicalEntity	manual digit 5 epithelium	An epithelium that is part of a manual digit 5.	EHDAA2:0000536|EMAPA:17442	hp.json	hand digit 5 epithelium|fore limb digit 5 epithelium|manual digit V epithelium	http://purl.obolibrary.org/obo/UBERON_0005648		
UBERON:0005647	biolink:AnatomicalEntity	manual digit 4 epithelium	An epithelium that is part of a manual digit 4.	EHDAA2:0000530|EMAPA:17439	hp.json	fore limb digit 4 epithelium|manual digit IV epithelium|hand digit 4 epithelium	http://purl.obolibrary.org/obo/UBERON_0005647		
UBERON:0005646	biolink:AnatomicalEntity	manual digit 3 epithelium	An epithelium that is part of a manual digit 3.	EMAPA:17436|EHDAA2:0000524	hp.json	fore limb digit 3 epithelium|manual digit III epithelium|hand digit 3 epithelium	http://purl.obolibrary.org/obo/UBERON_0005646		
CHEBI:22658	biolink:ChemicalSubstance	aspartate family amino acid	An L-alpha-amino acid which is L-aspartic acid or any of the essential amino acids biosynthesised from it (asparagine, lysine, methionine, threonine and isoleucine). A closed class.	PMID:4394351|PMID:4721772|PMID:4386082|PMID:5016260|PMID:5074276	hp.json	oxaloacetate/aspartate family amino acids|oxaloacetate family amino acids|oxaloacetate family amino acid|oxaloacetate/aspartate family amino acid|aspartate family amino acids|aspartic acid family amino acids|aspartic acid family amino acid	http://purl.obolibrary.org/obo/CHEBI_22658		3_STAR
UBERON:0005645	biolink:AnatomicalEntity	manual digit 2 epithelium	An epithelium that is part of a manual digit 2.	EMAPA:17433|EHDAA2:0000518	hp.json	hand digit 2 epithelium|manual digit II epithelium|fore limb digit 2 epithelium	http://purl.obolibrary.org/obo/UBERON_0005645		
HGNC:6925	biolink:Gene	MBP (human)	A protein coding gene MBP in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6925		
PATO:0001334	biolink:NamedThing	diameter	A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary.		hp.json		http://purl.obolibrary.org/obo/PATO_0001334		scalar_slim|attribute_slim|mpath_slim
GO:0043576	biolink:BiologicalProcess	regulation of respiratory gaseous exchange	Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.		hp.json		http://purl.obolibrary.org/obo/GO_0043576		
GO:0043586	biolink:BiologicalProcess	tongue development	The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.		hp.json	glossa development|lingua development	http://purl.obolibrary.org/obo/GO_0043586		
GO:0043588	biolink:BiologicalProcess	skin development	The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.		hp.json	animal skin development	http://purl.obolibrary.org/obo/GO_0043588		
GO:0043587	biolink:BiologicalProcess	tongue morphogenesis	The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.		hp.json	lingua morphogenesis|glossa morphogenesis	http://purl.obolibrary.org/obo/GO_0043587		
GO:0043589	biolink:BiologicalProcess	skin morphogenesis	The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0043589		
PATO:0001354	biolink:NamedThing	translucent	A optical quality inhering in a bearer by virtue of the bearer's exhibiting low opacity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001354		value_slim
PATO:0001355	biolink:NamedThing	convex	A shape quality that obtains by virtue of the bearer having inward facing edges; having a surface or boundary that curves or bulges outward, as the exterior of a sphere.		hp.json		http://purl.obolibrary.org/obo/PATO_0001355		value_slim|cell_quality
PATO:0001362	biolink:NamedThing	fragile	A structural quality inhering in a bearer by virtue of the bearer's disposition to being easily damaged or destroyed.		hp.json		http://purl.obolibrary.org/obo/PATO_0001362		disposition_slim|value_slim
GO:0006586	biolink:BiologicalProcess	indolalkylamine metabolic process	The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.		hp.json	indolamine metabolism|indolamine metabolic process|indolalkylamine metabolism	http://purl.obolibrary.org/obo/GO_0006586		
GO:0006584	biolink:BiologicalProcess	catecholamine metabolic process	The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.		hp.json	catecholamine metabolism	http://purl.obolibrary.org/obo/GO_0006584		
HP:0003704	biolink:PhenotypicFeature	Scapuloperoneal weakness		UMLS:C1842161	hp.json	Neurogenic scapuloperoneal syndrome	http://purl.obolibrary.org/obo/HP_0003704		
GO:0006582	biolink:BiologicalProcess	melanin metabolic process	The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.		hp.json	melanin metabolism	http://purl.obolibrary.org/obo/GO_0006582		
HP:0003707	biolink:PhenotypicFeature	Calf muscle pseudohypertrophy	Enlargement of the muscles of the calf due to their replacement by connective tissue or fat.	UMLS:C1839666	hp.json	Pseudohypertrophy of the calves	http://purl.obolibrary.org/obo/HP_0003707		
GO:0006590	biolink:NamedThing	thyroid hormone generation			hp.json		http://purl.obolibrary.org/obo/GO_0006590		
HP:0003701	biolink:PhenotypicFeature	Proximal muscle weakness	A lack of strength of the proximal muscles.	UMLS:C1838869|SNOMEDCT_US:249939004|UMLS:C0221629	hp.json	Muscle weakness, proximal|Proximal limb weakness|Proximal limb muscle weakness|Proximal neurogenic muscle weakness|Weakness in muscles of upper arms and upper legs	http://purl.obolibrary.org/obo/HP_0003701		
HP:0003700	biolink:PhenotypicFeature	Generalized amyotrophy	Generalized (diffuse, unlocalized) amyotrophy (muscle atrophy) affecting multiple muscles.	UMLS:C1389113	hp.json	Muscular atrophy, generalised|Muscle atrophy, generalised|Muscle atrophy, diffuse|Generalised muscle degeneration|Generalized muscle degeneration|Generalized muscle atrophy|Muscle atrophy, generalized|Diffuse skeletal muscle wasting|Diffuse muscle wasting|Muscular atrophy, generalized|Generalised amyotrophy|Generalised muscle atrophy|Diffuse muscle atrophy|Diffuse amyotrophy	http://purl.obolibrary.org/obo/HP_0003700		
PATO:0001309	biolink:NamedThing	duration	A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point.		hp.json	period|time	http://purl.obolibrary.org/obo/PATO_0001309		hpo_slim|attribute_slim
HP:0003717	biolink:PhenotypicFeature	Minimal subcutaneous fat		UMLS:C1859442	hp.json	Minimal fat below the skin	http://purl.obolibrary.org/obo/HP_0003717		
PATO:0001303	biolink:NamedThing	variability	A quality inhering in a bearer by virtue of the bearer's disposition to varying or changing.		hp.json	variability of a physical quality	http://purl.obolibrary.org/obo/PATO_0001303		attribute_slim
HP:0003716	biolink:PhenotypicFeature	Generalized muscular appearance from birth		UMLS:C1837799	hp.json	Generalised muscular appearance from birth	http://purl.obolibrary.org/obo/HP_0003716		
HP:0003715	biolink:PhenotypicFeature	Myofibrillar myopathy	Myofibrillar structural changes characterized by abnormal intracellular accumulation of the intermediate filament desmin and other proteins.	MSH:C580316|UMLS:C2678065|SNOMEDCT_US:699269005	hp.json	Myofibrillar changes	http://purl.obolibrary.org/obo/HP_0003715		
PATO:0001301	biolink:NamedThing	chromatic property	An optical quality that is the mixture, purity or pattern of wavelengths of light perceived by the observer.		hp.json		http://purl.obolibrary.org/obo/PATO_0001301		attribute_slim
GO:0006591	biolink:BiologicalProcess	ornithine metabolic process	The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.		hp.json	ornithine metabolism	http://purl.obolibrary.org/obo/GO_0006591		
HP:0003719	biolink:PhenotypicFeature	Muscle mounding		UMLS:C1853702	hp.json		http://purl.obolibrary.org/obo/HP_0003719		
HP:0003713	biolink:PhenotypicFeature	Muscle fiber necrosis	Abnormal cell death involving muscle fibers usually associated with break in, or absence of, muscle surface fiber membrane and resulting in irreversible damage to muscle fibers.	UMLS:C1850848	hp.json	Muscle fibre necrosis	http://purl.obolibrary.org/obo/HP_0003713		
HP:0003712	biolink:PhenotypicFeature	Skeletal muscle hypertrophy	Abnormal increase in muscle size and mass not due to training.	UMLS:C2265792	hp.json	Muscle hypertrophy|Muscular hypertrophy|Hypertrophic muscles|Increased skeletal muscle cells	http://purl.obolibrary.org/obo/HP_0003712		
PATO:0001300	biolink:NamedThing	optical quality	An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light.		hp.json		http://purl.obolibrary.org/obo/PATO_0001300		attribute_slim
HP:0003710	biolink:PhenotypicFeature	Exercise-induced muscle cramps	Sudden and involuntary contractions of one or more muscles brought on by physical exertion.	UMLS:C1855578	hp.json	Muscle cramps on exercise|Exercise-induced muscle cramps|Exercise-induced muscle cramping|Muscle cramps on exertion|Muscle cramps with exertion|Muscle cramps following exercise	http://purl.obolibrary.org/obo/HP_0003710		
GO:0006568	biolink:BiologicalProcess	tryptophan metabolic process	The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.	Wikipedia:Tryptophan	hp.json	tryptophan metabolism	http://purl.obolibrary.org/obo/GO_0006568		
GO:0006566	biolink:BiologicalProcess	threonine metabolic process	The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.	UM-BBD_pathwayID:met	hp.json	methionine and threonine metabolism|threonine metabolism|methionine and threonine metabolic process	http://purl.obolibrary.org/obo/GO_0006566		
GO:0006563	biolink:BiologicalProcess	L-serine metabolic process	The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.		hp.json	L-serine metabolism	http://purl.obolibrary.org/obo/GO_0006563		
GO:0006560	biolink:BiologicalProcess	proline metabolic process	The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.		hp.json	proline metabolism	http://purl.obolibrary.org/obo/GO_0006560		
GO:0031514	biolink:CellularComponent	motile cilium	A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.		hp.json	motile primary cilium|microtubule-based flagellum|motile secondary cilium|motile cilia|motile primary cilia|nodal cilium	http://purl.obolibrary.org/obo/GO_0031514		
GO:0006577	biolink:BiologicalProcess	amino-acid betaine metabolic process	The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid.		hp.json	betaine metabolism|betaine metabolic process	http://purl.obolibrary.org/obo/GO_0006577		
GO:0006575	biolink:BiologicalProcess	cellular modified amino acid metabolic process	The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.		hp.json	cellular amino acid derivative metabolism|cellular modified amino acid metabolism|modified amino acid metabolic process|cellular amino acid derivative metabolic process|modified amino acid metabolism|amino acid derivative metabolic process	http://purl.obolibrary.org/obo/GO_0006575		goslim_drosophila|goslim_generic|prokaryote_subset
GO:0006576	biolink:BiologicalProcess	cellular biogenic amine metabolic process	The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.		hp.json	biogenic amine metabolism	http://purl.obolibrary.org/obo/GO_0006576		
GO:0006573	biolink:BiologicalProcess	valine metabolic process	The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.		hp.json	valine metabolism	http://purl.obolibrary.org/obo/GO_0006573		
GO:0006570	biolink:BiologicalProcess	tyrosine metabolic process	The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.	Wikipedia:Tyrosine|UM-BBD_pathwayID:tyr	hp.json	tyrosine metabolism	http://purl.obolibrary.org/obo/GO_0006570		
PR:000007891	biolink:Protein	pro-glucagon	A protein that is a translation product of the human GCG gene or a 1:1 ortholog thereof.		hp.json	GCG	http://purl.obolibrary.org/obo/PR_000007891		
UBERON:0030276	biolink:AnatomicalEntity	lumbar spinal cord ventral horn		BIRNLEX:891	hp.json	lumbar spinal cord ventral horn|lumbar spinal cord anterior horn|lumbar spinal cord ventral horn	http://purl.obolibrary.org/obo/UBERON_0030276		
HP:0025093	biolink:PhenotypicFeature	Peripapillary exudate	A retinal exudate in the area surrounding the optic nerve head.		hp.json	Peripapillary exudation	http://purl.obolibrary.org/obo/HP_0025093		
HP:0025094	biolink:PhenotypicFeature	Disciform macular scar	A subretinal scar with a disc-like shape in the region of the macula.		hp.json		http://purl.obolibrary.org/obo/HP_0025094		
HP:0025095	biolink:PhenotypicFeature	Sneeze	A sudden violent, spasmodic, audible expiration of breath through the nose and mouth.		hp.json		http://purl.obolibrary.org/obo/HP_0025095		
HP:0025096	biolink:PhenotypicFeature	Paroxysmal sneezing	Unprovoked explosive pathological sneezing.		hp.json		http://purl.obolibrary.org/obo/HP_0025096		
HP:0025097	biolink:PhenotypicFeature	Eyelid myoclonus	Marked, involuntary jerking of the eyelids.		hp.json	Eyelid myoclonia|Blepharoclonus	http://purl.obolibrary.org/obo/HP_0025097		
HP:0025098	biolink:PhenotypicFeature	Dysgenesis of the hypothalamus	Structural abnormality of the hypothalamus related to defective development.		hp.json	Hypothalamic dysgenesis	http://purl.obolibrary.org/obo/HP_0025098		
HP:0025099	biolink:PhenotypicFeature	Dysgenesis of the thalamus	Structural abnormality of the thalamus related to defective development.		hp.json	Thalamic dysgenesis	http://purl.obolibrary.org/obo/HP_0025099		
HP:0025090	biolink:PhenotypicFeature	Abnormal large intestinal mucosa morphology	A structural anomaly of the mucous lining of the large intestine.		hp.json		http://purl.obolibrary.org/obo/HP_0025090		
HP:0025092	biolink:PhenotypicFeature	Epidermal acanthosis	Diffuse hypertrophy or thickening of the stratum spinosum of the epidermis (prickle cell layer of the skin).		hp.json	Acanthotic epidermis|Acanthosis|Thickening of upper layer of skin	http://purl.obolibrary.org/obo/HP_0025092		
CHEBI:32832	biolink:ChemicalSubstance	threoninate			hp.json	rel-(2R,3S)-2-amino-3-hydroxybutanoate|threoninate|threonine anion	http://purl.obolibrary.org/obo/CHEBI_32832		3_STAR
CHEBI:32833	biolink:ChemicalSubstance	threoninium			hp.json	rel-(1R,2S)-1-carboxy-2-hydroxypropan-1-aminium|threonine cation|threoninium	http://purl.obolibrary.org/obo/CHEBI_32833		3_STAR
GO:0043500	biolink:BiologicalProcess	muscle adaptation	A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.		hp.json	muscle plasticity	http://purl.obolibrary.org/obo/GO_0043500		goslim_pir
GO:0043502	biolink:BiologicalProcess	regulation of muscle adaptation	Any process that modulates the frequency, rate or extent of muscle adaptation.		hp.json	regulation of muscle plasticity	http://purl.obolibrary.org/obo/GO_0043502		
GO:0043501	biolink:BiologicalProcess	skeletal muscle adaptation	Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.		hp.json	skeletal muscle plasticity	http://purl.obolibrary.org/obo/GO_0043501		
GO:0043504	biolink:BiologicalProcess	mitochondrial DNA repair	The process of restoring mitochondrial DNA after damage.		hp.json		http://purl.obolibrary.org/obo/GO_0043504		
HP:0025082	biolink:PhenotypicFeature	Abnormal cutaneous elastic fiber morphology	Any structural anomaly of the elastic fibers of the skin. Elastic fibers are the essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils.		hp.json	Abnormal cutaneous elastic fibre morphology	http://purl.obolibrary.org/obo/HP_0025082		
HP:0025083	biolink:PhenotypicFeature	Elevated dermal desmosine content	An increased amount of desmosine measure in the skin. Desmosine is a cross-linking amino acid formed from lysyl residues in elastin.		hp.json		http://purl.obolibrary.org/obo/HP_0025083		
HP:0025084	biolink:PhenotypicFeature	Folliculitis	Inflammatory cells within the wall and ostia of the hair follicle, creating a follicular-based pustule.		hp.json	Follicular pustule	http://purl.obolibrary.org/obo/HP_0025084		
HP:0025085	biolink:PhenotypicFeature	Bloody diarrhea	Passage of many stools containing blood.		hp.json	Bloody diarrhea|Bloody stool|Bloody bowel movement|Bloody diarrhoea|Blood in stool	http://purl.obolibrary.org/obo/HP_0025085		
HP:0025086	biolink:PhenotypicFeature	Bloody mucoid diarrhea	Passage of many stools containing blood and mucus.		hp.json	Bloody mucoid diarrhoea	http://purl.obolibrary.org/obo/HP_0025086		
HP:0025087	biolink:PhenotypicFeature	Delayed recoil upon stretching of skin	Area of skin requiring an increased amount of time to return to its original shape after being stretched.		hp.json		http://purl.obolibrary.org/obo/HP_0025087		
HP:0025088	biolink:PhenotypicFeature	Onychomadesis	Complete shedding (separation) of the nail from the proximal matrix. Onychomadesis is the proximal separation of the nail plate from the nail matrix due to a temporary cessation of nail growth.		hp.json		http://purl.obolibrary.org/obo/HP_0025088		
HP:0025089	biolink:PhenotypicFeature	Feculent vomiting	Vomiting of material that is of fecal origin.		hp.json	Stercoraceous vomiting|Vomiting faecal matter|Faecal vomiting|Vomiting fecal matter|Fecal vomiting	http://purl.obolibrary.org/obo/HP_0025089		
HP:0025080	biolink:PhenotypicFeature	Orthokeratotic hyperkeratosis	A form of hyperkeratosis characterized by thickening of the cornified layer without retained nuclei.		hp.json		http://purl.obolibrary.org/obo/HP_0025080		
UBERON:0017271	biolink:AnatomicalEntity	upper primary premolar tooth			hp.json	maxillary primary premolar tooth|upper deciduous premolar tooth	http://purl.obolibrary.org/obo/UBERON_0017271		
UBERON:0017272	biolink:AnatomicalEntity	lower primary premolar tooth			hp.json	mandibular primary premolar tooth|lower deciduous premolar tooth	http://purl.obolibrary.org/obo/UBERON_0017272		
HP:0025081	biolink:PhenotypicFeature	Darier's sign	A skin change elicited by briskly rubbing the skin lesion in urticaria pigmentosa (UP), whereby the area begins to itch and becomes raised and surrounded by erythema. Unlike other forms of dermatographism, Darier's sign refers to urtication that is limited to the UP involved areas and, as in this case, spares the skin unaffected by UP.		hp.json		http://purl.obolibrary.org/obo/HP_0025081		
UBERON:0005291	biolink:AnatomicalEntity	embryonic tissue	A portion of tissue that is part of an embryo.	CALOHA:TS-2100	hp.json	developing tissue|portion of embryonic tissue	http://purl.obolibrary.org/obo/UBERON_0005291		upper_level|pheno_slim
UBERON:0005290	biolink:AnatomicalEntity	myelencephalon	The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP].	Wikipedia:Myelencephalon|MA:0000205|HBA:9512|EHDAA2:0001207|CALOHA:TS-2365|BTO:0000758|EHDAA:5526|DHBA:10662|CALOHA:TS-0607|MESH:D054024|VHOG:0000456|EMAPA:17082	hp.json	myelencephalon (medulla oblongata)	http://purl.obolibrary.org/obo/UBERON_0005290		uberon_slim
UBERON:0005299	biolink:AnatomicalEntity	prepuce of clitoris	A retractable double-layered fold of skin and mucous membrane that covers the clitoral glans.	FMA:20169|NCIT:C32590|EMAPA:30699|UMLS:C0227771	hp.json	prepuce of female|preputium clitoridis|prepuce of the clitoris|clitoral prepuce|clitoris prepuce|clitoral hood	http://purl.obolibrary.org/obo/UBERON_0005299		
HP:0025079	biolink:PhenotypicFeature	Pancreatic abscess	A circumscribed area of pus or necrotic debris in the parenchyma of the pancreas.		hp.json	Pancreas abscess	http://purl.obolibrary.org/obo/HP_0025079		
UBERON:0005298	biolink:AnatomicalEntity	skin of clitoris	A zone of skin that is part of a clitoris [Automatically generated definition].	FMA:20168	hp.json	clitoris skin	http://purl.obolibrary.org/obo/UBERON_0005298		
UBERON:0005297	biolink:AnatomicalEntity	testis sex cord	The testis cords are precursors to the rete testis. They play several different roles in the development of the male genitals[WP].	EHDAA2:0002011|VHOG:0001321|EHDAA:8152|EMAPA:29098	hp.json	testis primary sex cords|primary sex cord|testis primitive sex cord|testis cord	http://purl.obolibrary.org/obo/UBERON_0005297		pheno_slim
UBERON:0005296	biolink:AnatomicalEntity	ovary sex cord	Structures that develop from sex cords in the female. After further development they become the ovarian follicles.	EMAPA:31058|EHDAA:8130|VHOG:0001339|NCIT:C34134|UMLS:C1511527|EHDAA2:0001363	hp.json	cortical cord|secondary cord|ovigerous cord|cortical sex cord|ovary primitive sex cord|ovigerous cords	http://purl.obolibrary.org/obo/UBERON_0005296		
UBERON:0005295	biolink:AnatomicalEntity	sex cord	Cordlike masses of epithelial tissue that invaginate from germinal epithelium of the gonad and give rise to seminiferous tubules and rete testes in the male, and primary ovarian follicles and rete ovarii in the female.	RETIRED_EHDAA2:0001523|NCIT:C34183|EHDAA2:0004051|UMLS:C1512242	hp.json	gonadal cord|genital cord|gonad cord|primitive sex cord	http://purl.obolibrary.org/obo/UBERON_0005295		
UBERON:0005294	biolink:AnatomicalEntity	gonadal ridge	The elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary.	NCIT:C34184|XAO:0000018|EHDAA2:0004044|FMA:321917|EFO:0001414|UMLS:C1512243|AAO:0011047|NCIT:C34321|BTO:0001402|UMLS:C0231047|EMAPA:35899	hp.json	genital ridge|gonadal ridge|crista gonadalis|genital cord|indifferent gonadal ridge	http://purl.obolibrary.org/obo/UBERON_0005294		pheno_slim|efo_slim
OIO:hasOBONamespace	biolink:NamedThing	has_obo_namespace			hp.json		http://www.geneontology.org/formats/oboInOwl#hasOBONamespace		
UBERON:0005292	biolink:AnatomicalEntity	extraembryonic tissue	Portion of tissue that is contiguous with the embryo and is comprised of portions of tissue or cells that will not contribute to the embryo.	MAT:0000061|BTO:0003360|EFO:0001406|MIAA:0000061|CALOHA:TS-2119	hp.json	extra-embryonic tissue	http://purl.obolibrary.org/obo/UBERON_0005292		efo_slim
HP:0025071	biolink:PhenotypicFeature	U wave inversion	Direction of the U wave opposite to the T wave (i.e., below baseline) in leads with upright T waves.		hp.json		http://purl.obolibrary.org/obo/HP_0025071		
CHEBI:17203	biolink:ChemicalSubstance	L-proline	Pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles.	PMID:16033917|KEGG:D00035|PMID:15973048|Wikipedia:L-proline|PMID:16668324|PMID:16657874|PMID:14975886|PMID:17608428|PMID:15838615|PMID:16656443|PMID:15894682|MetaCyc:PRO|PMID:22201772|PMID:17127472|PMID:22482728|PMID:16501220|Gmelin:50152|PMID:16190672|PMID:19688381|PDBeChem:PRO|PMID:22491679|PMID:18551589|PMID:18802692|PMID:11076505|Beilstein:80810|Reaxys:80810|PMID:22451406|PMID:15576824|CAS:147-85-3|PMID:19215998|HMDB:HMDB0000162|KNApSAcK:C00001388|PMID:22139509|KEGG:C00148|PMID:19811425|CAS:147-85-3|PMID:22475019|PMID:19656302|DrugBank:DB00172|PMID:18973300|PMID:12770004|PMID:22770225|CAS:147-85-3|Drug_Central:4125|PMID:19580280	hp.json	proline|(S)-2-pyrrolidinecarboxylic acid|L-Prolin|PROLINE|(2S)-pyrrolidine-2-carboxylic acid|L-pyrrolidine-2-carboxylic acid|(-)-2-pyrrolidinecarboxylic acid|L-proline|(S)-2-carboxypyrrolidine|prolina|prolinum|(S)-pyrrolidine-2-carboxylic acid|(-)-(S)-proline|P|L-alpha-pyrrolidinecarboxylic acid|L-(-)-proline|(-)-proline|2-Pyrrolidinecarboxylic acid|L-Proline	http://purl.obolibrary.org/obo/CHEBI_17203		3_STAR
UBERON:0017270	biolink:AnatomicalEntity	secondary premolar tooth			hp.json	secondary premolar|permanent premolar tooth|secondary bicuspid	http://purl.obolibrary.org/obo/UBERON_0017270		
HP:0025072	biolink:PhenotypicFeature	Prominent U wave	Increased amplitude of the U wave, defined as an amplitude grerater than 1-2mm or 25 percent of the height of the T wave.		hp.json	Increased U wave amplitude	http://purl.obolibrary.org/obo/HP_0025072		
HP:0025073	biolink:PhenotypicFeature	Exercise-induced U wave inversion	U wave inversion that is induced by exercise stress testing.		hp.json		http://purl.obolibrary.org/obo/HP_0025073		
HP:0025074	biolink:PhenotypicFeature	Abnormal QRS complex	An anomaly of the complex formed by the Q, R, and S waves, which occur in rapid succession on the electrocardiogram.		hp.json		http://purl.obolibrary.org/obo/HP_0025074		
HP:0025075	biolink:PhenotypicFeature	Increased QRS voltage	Elevation of the voltage (height) of the QRS complex. There are several criteria in use, but the most common is the Sokolov-Lyon criterion (S wave depth in V1 + tallest R wave height in V5-V6 greater than 35 mm).		hp.json		http://purl.obolibrary.org/obo/HP_0025075		
HP:0025076	biolink:PhenotypicFeature	Abnormal QRS voltage	Abnormal amplitude of the QRS complex of the electrocardiogram (EKG).		hp.json		http://purl.obolibrary.org/obo/HP_0025076		
HP:0025077	biolink:PhenotypicFeature	Decreased QRS voltage	Reduced amplitude (height) of the QRS complex of the electrocardiogram (EKG), defined as amplitudes of all the QRS complexes in the limb leads are less than 5 mm or amplitudes of all the QRS complexes in the precordial leads less than 10 mm.		hp.json		http://purl.obolibrary.org/obo/HP_0025077		
HP:0025078	biolink:PhenotypicFeature	Electrical alternans	The QRS complexes of the electrocardiogram alternate in height.		hp.json		http://purl.obolibrary.org/obo/HP_0025078		
UBERON:0017261	biolink:AnatomicalEntity	intertarsal sesamoid	A sesamoid element that is part of a tarsal skeleton.		hp.json	tarsal sesamoid	http://purl.obolibrary.org/obo/UBERON_0017261		
HP:0025070	biolink:PhenotypicFeature	Abnormal U wave	An anomaly of the U wave of the electrocardiogram (EKG). The U wave is a small (0.5 mm) deflection immediately following the T wave, usually in the same direction as the T wave. It is best seen in leads V2 and V3.		hp.json		http://purl.obolibrary.org/obo/HP_0025070		
CHEBI:32816	biolink:ChemicalSubstance	pyruvic acid	A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.	DrugBank:DB00119|PMID:11762589|KEGG:C00022|PMID:22150460|CAS:127-17-3|Wikipedia:Pyruvic_acid|Beilstein:506211|MetaCyc:PYRUVATE|Reaxys:506211|LIPID_MAPS_instance:LMFA01060077|HMDB:HMDB0000243|CAS:127-17-3|PMID:22233273|PMID:19260671|PMID:22735334|YMDB:YMDB00175|Gmelin:101087|PDBeChem:PYR|KNApSAcK:C00001200|ECMDB:ECMDB00243|PMID:22770225	hp.json	alpha-ketopropionic acid|acide pyruvique|Brenztraubensaeure|CH3COCOOH|BTS|2-Oxopropanoic acid|Pyruvic acid|Pyroracemic acid|alpha-Oxopropionsaeure|acetylformic acid|2-ketopropionic acid|2-Oxopropansaeure|PYRUVIC ACID|2-oxopropanoic acid|2-Oxopropionsaeure|Acetylformic acid|2-oxopropanoic acid|pyruvic acid	http://purl.obolibrary.org/obo/CHEBI_32816		3_STAR
UBERON:0017269	biolink:AnatomicalEntity	primary premolar tooth			hp.json	primary bicuspid|deciduous premolar tooth|primary premolar	http://purl.obolibrary.org/obo/UBERON_0017269		
UBERON:0005288	biolink:AnatomicalEntity	tela choroidea of third ventricle	Tela chorioidea that lines the third ventricle[ZFA]. The part of the choroid plexus in relation to the body of the ventricle forms the vascular fringed margin of a triangular process of pia mater, named the tela chorioidea of the third ventricle, and projects from under cover of the lateral edge of the fornix. Blood is supplied by branches from the superior cerebellar artery[WP].	TAO:0005159|BAMS:tc3v|FMA:78463|ZFA:0005159	hp.json	tela choroidea ventriculi tertii|tela choroidea ventriculi tertii|tela chorioidea of third ventricle|choroid membrane of third ventricle|tela chorioidea third ventricle|tela choroidea third ventricle	http://purl.obolibrary.org/obo/UBERON_0005288		vertebrate_core
HP:0025068	biolink:PhenotypicFeature	Incomitant strabismus	Strabismus in which the angle of deviation differs depending upon the direction of gaze or according to which eye is fixing, associated with: (i) defective movement of the eye, (ii) asymmetrical accommodative effort.		hp.json		http://purl.obolibrary.org/obo/HP_0025068		
UBERON:0005287	biolink:AnatomicalEntity	tela choroidea of fourth ventricle	Tela chorioidea that lines the fourth ventricle[ZFA]. The tela chorioidea of the fourth ventricle is the name applied to the triangular fold of pia mater which is carried upward between the cerebellum and the medulla oblongata. It consists of two layers, which are continuous with each other in front, and are more or less adherent throughout: The posterior layer covers the antero-inferior surface of the cerebellum. The anterior layer is applied to the structures which form the lower part of the roof of the ventricle, and is continuous inferiorly with the pia mater on the inferior peduncles and closed part of the medulla[WP].	TAO:0005158|BAMS:tc4v|FMA:78493|ZFA:0005158	hp.json	choroid membrane of fourth ventricle|tela choroidea of fourth ventricle|tela choroidea fourth ventricle|choroid membrane|tela choroidea|tela choroidea ventriculi quarti|tela choroidea ventriculi quarti|tela chorioidea fourth ventricle	http://purl.obolibrary.org/obo/UBERON_0005287		vertebrate_core
HP:0025069	biolink:PhenotypicFeature	Concomitant strabismus	Strabismus in which the angle of deviation of the squiting eye remains the same in relation to the other eye, in all directions of gaze, and whichever eye is fixing.		hp.json	Comitant strabismus	http://purl.obolibrary.org/obo/HP_0025069		
UBERON:0005286	biolink:AnatomicalEntity	tela choroidea of midbrain cerebral aqueduct	Tela choroidea that lines the tectal ventricle.	TAO:0005157|ZFA:0005157	hp.json	tela chorioidea tectal ventricle|tela choroidea tectal ventricle|tela choroidea of cerebral aqueduct	http://purl.obolibrary.org/obo/UBERON_0005286		
GO:0043524	biolink:BiologicalProcess	negative regulation of neuron apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.		hp.json	down-regulation of neuron apoptosis|neuron survival|negative regulation of programmed cell death, neurons|downregulation of neuron apoptosis|negative regulation of neuron apoptosis|down regulation of neuron apoptosis|inhibition of neuron apoptosis	http://purl.obolibrary.org/obo/GO_0043524		
UBERON:0005283	biolink:AnatomicalEntity	tela choroidea	A structure found in the walls of the ventricles of the brain, consisting of part of the meninges (pia mater in mammals) plus ependyma[cjm].	ZFA:0000447|TAO:0000447|FMA:242849	hp.json	tela chorioidea	http://purl.obolibrary.org/obo/UBERON_0005283		vertebrate_core|pheno_slim
GO:0043523	biolink:BiologicalProcess	regulation of neuron apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.		hp.json	regulation of programmed cell death of neuronal cells|regulation of programmed cell death, neurons|regulation of neuronal cell programmed cell death|regulation of neuron apoptosis|regulation of apoptosis of neurons|regulation of apoptosis of neuronal cells|regulation of neuron programmed cell death	http://purl.obolibrary.org/obo/GO_0043523		
UBERON:0005282	biolink:AnatomicalEntity	ventricular system of brain		VHOG:0000005|CALOHA:TS-1295|EMAPA:37447|FMA:242787	hp.json	brain ventricular system	http://purl.obolibrary.org/obo/UBERON_0005282		
UBERON:0005281	biolink:AnatomicalEntity	ventricular system of central nervous system	A set of structures containing cerebrospinal fluid in the brain. It is continuous with the central canal of the spinal cord[WP].	FMA:242675|TAO:0001261|EHDAA2:0004362|EFO:0003650|EV:0100306|MBA:73|ZFA:0001261	hp.json	ventriculi cerebri|ventricular system of neuraxis|ventricle system|ventricular system|CNS ventricular system	http://purl.obolibrary.org/obo/UBERON_0005281		efo_slim|vertebrate_core
GO:0043525	biolink:BiologicalProcess	positive regulation of neuron apoptotic process	Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.		hp.json	upregulation of neuron apoptosis|up regulation of neuron apoptosis|stimulation of neuron apoptosis|activation of neuron apoptosis|up-regulation of neuron apoptosis|positive regulation of programmed cell death, neurons|positive regulation of neuron apoptosis	http://purl.obolibrary.org/obo/GO_0043525		
HP:0025060	biolink:PhenotypicFeature	Multifocal splenic abscess	Multiple abscess lesions in the spleen.		hp.json	Multilocular splenic abscess	http://purl.obolibrary.org/obo/HP_0025060		
HP:0025061	biolink:PhenotypicFeature	Unifocal splenic abscess	Single (solitary) abscess in the spleen.		hp.json	Unilocular splenic abscess|Solitary splenic abscess	http://purl.obolibrary.org/obo/HP_0025061		
HP:0025062	biolink:PhenotypicFeature	Geophagia	The practice of eating earth or soil-like substrates such as clay or chalk.		hp.json	Geophagy	http://purl.obolibrary.org/obo/HP_0025062		
HP:0025063	biolink:PhenotypicFeature	Scaphoid abdomen	The anterior abdominal wall is sunken and presents a concave rather than a convex contour.		hp.json		http://purl.obolibrary.org/obo/HP_0025063		
HP:0025064	biolink:PhenotypicFeature	Thalamic hemorrhage	Bleeding in the thalamus.		hp.json	Thalamic haemorrhage	http://purl.obolibrary.org/obo/HP_0025064		
HP:0025065	biolink:PhenotypicFeature	Abnormal mean corpuscular volume	A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.		hp.json	Abnormal MCV|Abnormal erythrocyte volume	http://purl.obolibrary.org/obo/HP_0025065		
HP:0025066	biolink:PhenotypicFeature	Decreased mean corpuscular volume	A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters).		hp.json	Decreased MCV|Reduced erythrocyte volume|Microcytosis	http://purl.obolibrary.org/obo/HP_0025066		
UBERON:0005289	biolink:AnatomicalEntity	tela choroidea of telencephalic ventricle	Tela chorioidea that lines the telencephalic ventricle.	ZFA:0005160|BAMS:tclv|TAO:0005160|FMA:83712	hp.json	tela choroidea telencephalic ventricle|tela chorioidea telencephalic ventricle|tela chorioidea of lateral ventricle|tela choroidea of lateral ventricle|tela choroidea (ventriculi lateralis)|tela chorioidea of telencephalic ventricle	http://purl.obolibrary.org/obo/UBERON_0005289		vertebrate_core
GO:0043535	biolink:BiologicalProcess	regulation of blood vessel endothelial cell migration	Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.		hp.json		http://purl.obolibrary.org/obo/GO_0043535		
GO:0043534	biolink:BiologicalProcess	blood vessel endothelial cell migration	The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_0043534		
GO:0043537	biolink:BiologicalProcess	negative regulation of blood vessel endothelial cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.		hp.json	down-regulation of blood vessel endothelial cell migration|down regulation of blood vessel endothelial cell migration|inhibition of blood vessel endothelial cell migration|downregulation of blood vessel endothelial cell migration	http://purl.obolibrary.org/obo/GO_0043537		
GO:0043536	biolink:BiologicalProcess	positive regulation of blood vessel endothelial cell migration	Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.		hp.json	stimulation of blood vessel endothelial cell migration|upregulation of blood vessel endothelial cell migration|up-regulation of blood vessel endothelial cell migration|up regulation of blood vessel endothelial cell migration|activation of blood vessel endothelial cell migration	http://purl.obolibrary.org/obo/GO_0043536		
GO:0043542	biolink:BiologicalProcess	endothelial cell migration	The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.		hp.json		http://purl.obolibrary.org/obo/GO_0043542		
GO:0043549	biolink:BiologicalProcess	regulation of kinase activity	Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.		hp.json		http://purl.obolibrary.org/obo/GO_0043549		
UBERON:4100000	biolink:AnatomicalEntity	skeletal element projection	Anatomical projection that is composed of bone or cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_4100000		
GO:0031594	biolink:CellularComponent	neuromuscular junction	The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.	Wikipedia:Neuromuscular_junction|NIF_Subcellular:sao1124888485	hp.json	motor endplate|NMJ	http://purl.obolibrary.org/obo/GO_0031594		
CHEBI:17151	biolink:ChemicalSubstance	xylitol	A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from xylose by reduction of the carbonyl group.	PMID:17216457|CAS:87-99-0|PMID:16708791|Gmelin:82893|PMID:11154411|PMID:23338824|PMID:16901854|PMID:18316079|PMID:12061879|CAS:87-99-0|PMID:23287496|CAS:87-99-0|Beilstein:1720523|PMID:23916161|PMID:15377394|Reaxys:1720523|PMID:25108762|PMID:23589387|PMID:22791282|PMID:17979222|KEGG:D00061|PMID:23957303|PMID:23796483|PMID:20030329|Drug_Central:4604|PMID:24643482|PDBeChem:XYL|PMID:22735334|PMID:23615861|PMID:24012734|HMDB:HMDB0002917|KEGG:C00379|PMID:11163479|PMID:23247825|MetaCyc:XYLITOL|PMID:17336832|DrugBank:DB01904|PMID:23597921|Wikipedia:Xylitol|PMID:17216458	hp.json	(2R,3R,4S)-Pentane-1,2,3,4,5-pentaol|xylitol|xylite|Xylit|(2R,3r,4S)-pentane-1,2,3,4,5-pentol|L-xylitol|Xylitol|D-XYLITOL|meso-xylitol	http://purl.obolibrary.org/obo/CHEBI_17151		3_STAR
CHEBI:42111	biolink:ChemicalSubstance	(R)-lactic acid	An optically active form of lactic acid having (R)-configuration.	Wikipedia:Lactic_acid|HMDB:HMDB0001311|PMID:22277286|PDBeChem:LAC|Gmelin:362718|PMID:22127808|KNApSAcK:C00019549|DrugBank:DB04398|Beilstein:1720252|Reaxys:1720252|DrugBank:DB03066|CAS:10326-41-7|KEGG:C00256|CAS:10326-41-7|PMID:22344644|PMID:21842515	hp.json	D-2-Hydroxypropionic acid|LACTIC ACID|(2R)-2-hydroxypropanoic acid|D-Milchsaeure|(R)-(-)-lactic acid|D-Lactic acid|D-lactic acid|(-)-lactic acid|D-2-Hydroxypropanoic acid	http://purl.obolibrary.org/obo/CHEBI_42111		3_STAR
HP:0001046	biolink:PhenotypicFeature	Intermittent jaundice	Jaundice that is sometimes present, sometimes not.	UMLS:C4025805	hp.json	Intermittent yellow skin|Intermittent icterus|Intermittent yellowing of skin	http://purl.obolibrary.org/obo/HP_0001046		secondary_consequence
HP:0025013	biolink:PhenotypicFeature	Decerebrate rigidity	A type of rigidity that is manifested by an exaggerated extensor posture of all extremities.		hp.json	Decerebrate posturing	http://purl.obolibrary.org/obo/HP_0025013		
HP:0001047	biolink:PhenotypicFeature	Atopic dermatitis	Atopic dermatitis (AD) or atopic eczema is an itchy, inflammatory skin condition with a predilection for the skin flexures. It is characterized by poorly defined erythema with edema, vesicles, and weeping in the acute stage and skin thickening (lichenification) in the chronic stage.	SNOMEDCT_US:200775004|SNOMEDCT_US:24079001|UMLS:C0011615|MSH:D003876|UMLS:C4280605	hp.json	Atopic dermatitis, chronic|Baby eczema|Dermatitis, Atopic	http://purl.obolibrary.org/obo/HP_0001047		
HP:0025014	biolink:PhenotypicFeature	Subcutaneous spheroids	Small, hard cyst-like nodules, freely moveable in the subcutis over the bony prominences of the legs and arms, which have an outer calcified layer with a translucent core on x-ray.		hp.json		http://purl.obolibrary.org/obo/HP_0025014		
UBERON:0005352	biolink:AnatomicalEntity	spermatic cord	The cord-like structure in males comprising the vas deferens and associated tissue that runs from the abdomen down to each testis[MP].	NCIT:C12329|UMLS:C0037855|GAID:395|FMA:19937|MESH:D013085	hp.json	spermatic chord|funiculus spermaticus	http://purl.obolibrary.org/obo/UBERON_0005352		pheno_slim
HP:0025015	biolink:PhenotypicFeature	Abnormal vascular morphology			hp.json		http://purl.obolibrary.org/obo/HP_0025015		
HP:0001045	biolink:PhenotypicFeature	Vitiligo		UMLS:C0042900|SNOMEDCT_US:56727007|MSH:D014820	hp.json	Blotchy loss of skin colour|Blotchy loss of skin color	http://purl.obolibrary.org/obo/HP_0001045		
HP:0025016	biolink:PhenotypicFeature	Abnormal capillary morphology	A structural anomaly of the tiny blood vessels that connect arterioles with venules and whose walls act as semipermeable membranes that mediate the diffusion of fluids and gases between the blood circulation and body tissues.		hp.json		http://purl.obolibrary.org/obo/HP_0025016		
CHEBI:32784	biolink:ChemicalSubstance	tyrosinate(1-)	An alpha-amino-acid anion that is the conjugate base of tyrosine, arising from deprotonation of the carboxy group.	Gmelin:329372|Beilstein:3548387|Beilstein:4139515	hp.json	2-amino-3-(4-hydroxyphenyl)propanoate|hydrogen tyrosinate|tyrosine anion|tyrosinate(1-)	http://purl.obolibrary.org/obo/CHEBI_32784		3_STAR
HP:0025017	biolink:PhenotypicFeature	Capillary fragility	Reduced resistance to rupture of capillary blood vessels. Capillary fragility may manifest as a bleeding diathesis with spontaneous ecchymoses (bruises).		hp.json		http://purl.obolibrary.org/obo/HP_0025017		
CHEBI:32785	biolink:ChemicalSubstance	tyrosinate(2-)			hp.json	tyrosine dianion|tyrosinate|2-amino-3-(4-oxidophenyl)propanoate|tyrosinate(2-)	http://purl.obolibrary.org/obo/CHEBI_32785		3_STAR
HP:0025018	biolink:PhenotypicFeature	Abnormal capillary physiology	A functional anomaly of the tiny blood vessels that connect arterioles with venules and whose walls act as semipermeable membranes that mediate the diffusion of fluids and gases between the blood circulation and body tissues.		hp.json		http://purl.obolibrary.org/obo/HP_0025018		
CHEBI:32786	biolink:ChemicalSubstance	tyrosinium	An alpha-amino-acid cation that is the conjugate acid of tyrosine, arising from protonation of the amino group.		hp.json	tyrosine cation|1-carboxy-2-(4-hydroxyphenyl)ethanaminium|tyrosinium	http://purl.obolibrary.org/obo/CHEBI_32786		3_STAR
HP:0001048	biolink:PhenotypicFeature	Cavernous hemangioma	The presence of a cavernous hemangioma. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma.	SNOMEDCT_US:33377007|UMLS:C0018920|SNOMEDCT_US:56975005|NCIT:C3086|MSH:D006392|SNOMEDCT_US:416824008|MEDDRA:10055899	hp.json	Cavernous haemangioma|Collection of dilated blood vessels that forms mass|Cavernous angioma	http://purl.obolibrary.org/obo/HP_0001048		hposlim_core
HP:0025019	biolink:PhenotypicFeature	Arterial rupture	Sudden breakage of an artery leading to leakage of blood from the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025019		
HP:0001049	biolink:PhenotypicFeature	Absent dorsal skin creases over affected joints		UMLS:C1861400	hp.json		http://purl.obolibrary.org/obo/HP_0001049		
HP:0001042	biolink:PhenotypicFeature	High axial triradius		UMLS:C4025806	hp.json		http://purl.obolibrary.org/obo/HP_0001042		
UBERON:0005358	biolink:AnatomicalEntity	ventricle of nervous system	A layer in the central nervous system that lines system of communicating cavities in the brain and spinal cord.	FMA:242770|EMAPA:35209	hp.json	region of wall of ventricular system of neuraxis|ventricular layer	http://purl.obolibrary.org/obo/UBERON_0005358		
HP:0025010	biolink:PhenotypicFeature	Foveal atrophy	Partial or complete loss of foveal tissue that was once present.		hp.json		http://purl.obolibrary.org/obo/HP_0025010		
HP:0001043	biolink:PhenotypicFeature	Prominent scalp veins		UMLS:C1856542	hp.json	Prominent scalp veins	http://purl.obolibrary.org/obo/HP_0001043		
UBERON:0005356	biolink:AnatomicalEntity	Rathke's pouch	A pouch of ectoderm that grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland[MP]. In embryogenesis, Rathke's pouch is a depression in the roof of the developing mouth in front of the buccopharyngeal membrane. It gives rise to the anterior pituitary (adenohypophysis), a part of the endocrine system[WP].	NCIT:C34281|AAO:0011094|XAO:0000430|EHDAA2:0001588|FMA:302929|UMLS:C0229548|NCIT:C54098|UMLS:C1709841|EMAPA:16725|VHOG:0000674	hp.json	nasohypophyseal pouch|pouch of Rathke|hypophyseal pouch|craniopharyngeal pouch|Rathke's cleft|Rathke's cyst|Rathke pouch|Rathkes pouch epithelium|Rathke's pocket|craniobuccal pouch|adenohypophysial pouch|pituitary diverticulum|hypophyseal diverticulum	http://purl.obolibrary.org/obo/UBERON_0005356		pheno_slim
HP:0001040	biolink:PhenotypicFeature	Multiple pterygia		UMLS:C1867448	hp.json		http://purl.obolibrary.org/obo/HP_0001040		
HP:0025011	biolink:PhenotypicFeature	Pyriform aperture stenosis	Narrowing of the anterior nasal aperture (piriform or pyriform aperture), which is a pear-shaped opening in the skull that forms the bony inlet of the nose.		hp.json		http://purl.obolibrary.org/obo/HP_0025011		
HP:0001041	biolink:PhenotypicFeature	Facial erythema	Redness of the skin of the face, caused by hyperemia of the capillaries in the lower layers of the skin.	MSH:D012393|UMLS:C0005874|SNOMEDCT_US:271811009|UMLS:C0239488|SNOMEDCT_US:20255002|MSH:D001821|SNOMEDCT_US:398909004|UMLS:C4020880|UMLS:C0035854	hp.json	Blushing|Ruddy face|Blushed cheeks|Red face|Rosacea|Red in the face	http://purl.obolibrary.org/obo/HP_0001041		
HP:0025012	biolink:PhenotypicFeature	Status cribrosum	Diffusely widened perivascular spaces in the basal ganglia, affecting especially the corpus striatum. Status cribrosum is usually symmetrical, with the perivascular spaces showing CSF signal and without diffusion restriction. The word cribriform means sievelike, with multiple perforations.		hp.json		http://purl.obolibrary.org/obo/HP_0025012		
UBERON:0005343	biolink:AnatomicalEntity	cortical plate	The outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers[MP].	PBA:294021914|BAMS:CTXpl|EMAPA:32711|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2702|MBA:695|DHBA:10515	hp.json	CxP|CP|neocortex cortical plate|future neocortex|future neocortex|future cortical layers II-VI|cerebral cortex cortical plate|future cortical layers II-VI|CxP	http://purl.obolibrary.org/obo/UBERON_0005343		pheno_slim
HP:0001057	biolink:PhenotypicFeature	Aplasia cutis congenita	A developmental defect resulting in the congenital absence of skin in multiple or solitary non-inflammatory, well-demarcated, oval or circular ulcers with a diameter of about 1 to 2 cm. Aplasia cutis congenita most commonly occurs on the scalp, but may present in the face, trunk, or limbs.	SNOMEDCT_US:254237003|SNOMEDCT_US:74223008|MEDDRA:10002963|UMLS:C0282160|UMLS:C0265989|MSH:D004476|SNOMEDCT_US:35484002	hp.json	Congenital scars|Congenital absence of skin|Cutis aplasia|Absence of part of skin at birth	http://purl.obolibrary.org/obo/HP_0001057		hposlim_core
PR:000007812	biolink:Protein	UDP-glucose 4-epimerase	A protein that is a translation product of the human GALE gene or a 1:1 ortholog thereof.		hp.json	UDP-GlcNAc 4-epimerase|UDP-N-acetylglucosamine 4-epimerase|galactowaldenase|UDP-GalNAc 4-epimerase|GALE|UDP-galactose 4-epimerase	http://purl.obolibrary.org/obo/PR_000007812		
HP:0001058	biolink:PhenotypicFeature	Poor wound healing	A reduced ability to heal cutaneous wounds.	UMLS:C1851789	hp.json	Poor wound healing	http://purl.obolibrary.org/obo/HP_0001058		hposlim_core
HP:0001055	biolink:PhenotypicFeature	Erysipelas	Increased susceptibility to erysipelas, as manifested by a medical history of repeated episodes of erysipelas, which is a superficial infection of the skin, typically involving the lymphatic system.	MEDDRA:10015145|SNOMEDCT_US:44653001|SNOMEDCT_US:51510002|UMLS:C0014714|MSH:D004886|UMLS:C0014733|MSH:D004881	hp.json	St. Anthony's Fire	http://purl.obolibrary.org/obo/HP_0001055		hposlim_core
HP:0025004	biolink:PhenotypicFeature	Hallux rigidus	Osteoarthritis of the metatarsophalangeal joint of the first toe.	SNOMEDCT_US:6654000|UMLS:C0264134|MSH:D020859	hp.json	Arthritis of the big toe	http://purl.obolibrary.org/obo/HP_0025004		
UBERON:0005341	biolink:AnatomicalEntity	ventral commissure	The fiber tracts that connect the ventral region of the two cerebral hemispheres and span the longitudinal fissure, including the anterior and the habenular commissures[MP].	EMAPA:37845	hp.json		http://purl.obolibrary.org/obo/UBERON_0005341		pheno_slim
HP:0025005	biolink:PhenotypicFeature	Thickening of glomerular capillary wall	Widening of the wall of capillary blood vessels in the glomerulus. This feature may be produced by deposits and other changes affecting either subepithelial and subendothelial regions or the glomerular basement membrane itself.		hp.json		http://purl.obolibrary.org/obo/HP_0025005		
HP:0001056	biolink:PhenotypicFeature	Milia	Presence of multiple small cysts containing keratin (skin protein) and presenting as tiny pearly-white bumps just under the surface of the skin.	SNOMEDCT_US:254679001|SNOMEDCT_US:37719003|SNOMEDCT_US:254683001|UMLS:C0345996	hp.json	Milk spot|Millium cyst	http://purl.obolibrary.org/obo/HP_0001056		hposlim_core
UBERON:0005340	biolink:AnatomicalEntity	dorsal telencephalic commissure	A fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure[MP].	NLX:147892|EMAPA:37844	hp.json	dorsal commissure	http://purl.obolibrary.org/obo/UBERON_0005340		pheno_slim
HP:0025006	biolink:PhenotypicFeature	Abnormal glomerular capillary morphology	A structural anomaly of the capillary blood vessels in the renal glomerulus.		hp.json	Abnormalities of the glomerular capillary wall	http://purl.obolibrary.org/obo/HP_0025006		
HP:0025007	biolink:PhenotypicFeature	Ectopic fovea	An abnormal anatomic position of the fovea, the small, central pit composed of closely packed cones that is located in the macula of the retina.		hp.json	Ectopic macula	http://purl.obolibrary.org/obo/HP_0025007		
CHEBI:32796	biolink:ChemicalSubstance	(R)-2-hydroxyglutaric acid	The (R)-enantiomer of 2-hydroxyglutaric acid.	KEGG:C02911|MetaCyc:R-2-HYDROXYGLUTARATE|Beilstein:1723806|Reaxys:1723806|KEGG:C01087	hp.json	(R)-Hydroxyglutarate|(2R)-2-hydroxypentanedioic acid|(R)-2-Hydroxyglutarate	http://purl.obolibrary.org/obo/CHEBI_32796		3_STAR
CHEBI:32797	biolink:ChemicalSubstance	(S)-2-hydroxyglutaric acid		KEGG:C03196|MetaCyc:CPD-381|CAS:13095-48-2|Gmelin:1218919|Reaxys:1723807|Beilstein:1723807	hp.json	(2S)-2-hydroxypentanedioic acid|(S)-2-Hydroxyglutarate	http://purl.obolibrary.org/obo/CHEBI_32797		3_STAR
HP:0025008	biolink:PhenotypicFeature	Tracheal tug on inspiration	Downward movement of the trachea during inspiration due to downward traction on the tracheobronchial tree.		hp.json		http://purl.obolibrary.org/obo/HP_0025008		
HP:0001059	biolink:PhenotypicFeature	Pterygium	Pterygia are 'winglike' triangular membranes occurring in the neck, eyes, knees, elbows, ankles or digits.	MSH:D011625|SNOMEDCT_US:77489003|UMLS:C0033999	hp.json	Pterygia	http://purl.obolibrary.org/obo/HP_0001059		
HP:0025009	biolink:PhenotypicFeature	Forward slanting upper incisors	The upper incisors deviate from the normal angle of being roughly parallel to the surface of the face and instead slant outwards.		hp.json	Protruding upper incisors|Proclination of the upper incisors|Forward directed upper incisors	http://purl.obolibrary.org/obo/HP_0025009		
CHEBI:17137	biolink:ChemicalSubstance	hydrogensulfite		CAS:15181-46-1|CAS:15181-46-1|PDBeChem:SO3|Gmelin:1455|KEGG:C11481	hp.json	hydrogentrioxosulfate(1-)|hydrogen(trioxidosulfate)(1-)|hydrogentrioxosulfate(IV)|Bisulfite|hydrosulfite anion|bisulfite|[SO2(OH)](-)|monohydrogentrioxosulfate|hydrogen sulfite(1-)|HSO3(-)|Hydrogen sulfite|HSO3-|bisulphite|hydrogensulfite(1-)|hydroxidodioxidosulfate(1-)	http://purl.obolibrary.org/obo/CHEBI_17137		3_STAR
HP:0001050	biolink:PhenotypicFeature	Plethora		SNOMEDCT_US:75246004|UMLS:C0232370	hp.json		http://purl.obolibrary.org/obo/HP_0001050		
HP:0001053	biolink:PhenotypicFeature	Hypopigmented skin patches		UMLS:C1836735	hp.json	Patchy loss of skin color|Patchy loss of skin colour	http://purl.obolibrary.org/obo/HP_0001053		
HP:0001054	biolink:PhenotypicFeature	Numerous nevi		UMLS:C1849677	hp.json	Multiple pigmented nevi|Numerous moles	http://purl.obolibrary.org/obo/HP_0001054		
HP:0001051	biolink:PhenotypicFeature	Seborrheic dermatitis	Seborrheic dermatitis is a form of eczema which is closely related to dandruff. It causes dry or greasy peeling of the scalp, eyebrows, and face, and sometimes trunk.	UMLS:C0036508|SNOMEDCT_US:50563003|UMLS:C3806554|SNOMEDCT_US:86708008|MSH:D012628	hp.json	Seborrheic eczema|Seborrhea|Dysseborrheic dermatitis	http://purl.obolibrary.org/obo/HP_0001051		
HP:0001052	biolink:PhenotypicFeature	Nevus flammeus	A congenital vascular malformation consisting of superficial and deep dilated capillaries in the skin which produce a reddish to purplish discolouration of the skin.	SNOMEDCT_US:416377005|MEDDRA:10067193|MSH:D019339|SNOMEDCT_US:254211001|UMLS:C0235752	hp.json	Nevus simplex|port-wine stain	http://purl.obolibrary.org/obo/HP_0001052		hposlim_core
HP:0003687	biolink:PhenotypicFeature	Centrally nucleated skeletal muscle fibers	An abnormality in which the nuclei of sarcomeres take on an abnormally central localization (or in which this feature is found in an increased proportion of muscle cells).	UMLS:C1842170	hp.json	Centralised sarcomeric nuclei|Centralised nuclei|Centralized sarcomeric nuclei|Centrally nucleated skeletal muscle fibres|Centralized nuclei|Central nuclei	http://purl.obolibrary.org/obo/HP_0003687		
HP:0001024	biolink:PhenotypicFeature	Skin dimple over apex of long bone angulation		UMLS:C1855815	hp.json		http://purl.obolibrary.org/obo/HP_0001024		
UBERON:0005332	biolink:AnatomicalEntity	mesonephric S-shaped body	The mesonephric S-shaped body is the successor of the mesonephric comma-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005332		
HP:0001025	biolink:PhenotypicFeature	Urticaria	Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure.	SNOMEDCT_US:64305001|MEDDRA:10046735|MSH:D014581|UMLS:C0042109|SNOMEDCT_US:247472004|SNOMEDCT_US:126485001	hp.json	Hives	http://purl.obolibrary.org/obo/HP_0001025		hposlim_core
UBERON:0005331	biolink:AnatomicalEntity	mesonephric renal vesicle	The renal vesicle is the primordial structure of the mesonephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO].	ZFA:0005586	hp.json	mesonephric vesicle	http://purl.obolibrary.org/obo/UBERON_0005331		
HP:0001022	biolink:PhenotypicFeature	Albinism	An abnormal reduction in the amount of pigmentation (reduced or absent) of skin, hair and eye (iris and retina).	MSH:D000417|UMLS:C0001916|UMLS:C0333913|SNOMEDCT_US:18064000|SNOMEDCT_US:15890002	hp.json	Achromasia|Albinism	http://purl.obolibrary.org/obo/HP_0001022		
UBERON:0007997	biolink:AnatomicalEntity	sesamoid bone of manus	A sesamoid bone that is part of a manus.	FMA:42353	hp.json	sesamoid bone of hand	http://purl.obolibrary.org/obo/UBERON_0007997		
UBERON:0005330	biolink:AnatomicalEntity	mesonephric nephron epithelium	The mesonephric nephron epithelium is a tissue that covers the surface of a nephron in the mesonephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005330		
HP:0001028	biolink:PhenotypicFeature	Hemangioma	A hemangioma is a benign tumor characterized by blood-filled spaces lined by benign endothelial cells. A hemangioma characterized by large endothelial spaces (caverns) is called a cavernous hemangioma (in contrast to a hemangioma with small endothelial spaces, which is called capillary hemangioma).	UMLS:C0018916|SNOMEDCT_US:253053003|SNOMEDCT_US:400210000|NCIT:C3085|SNOMEDCT_US:2099007|MSH:D006391	hp.json	Hemangiomata|Strawberry mark	http://purl.obolibrary.org/obo/HP_0001028		
HP:0001029	biolink:PhenotypicFeature	Poikiloderma	Poikiloderma refers to a patch of skin with (1) reticulated hypopigmentation and hyperpigmentation, (2) wrinkling secondary to epidermal atrophy, and (3) telangiectasias.	MEDDRA:10057041|SNOMEDCT_US:402685001|UMLS:C0392777|SNOMEDCT_US:70114006	hp.json		http://purl.obolibrary.org/obo/HP_0001029		hposlim_core
HP:0001026	biolink:PhenotypicFeature	Penetrating foot ulcers		UMLS:C4025809	hp.json	Penetrating foot ulcers	http://purl.obolibrary.org/obo/HP_0001026		
HP:0003689	biolink:PhenotypicFeature	Multiple mitochondrial DNA deletions	The presence of multiple deletions of mitochondrial DNA (mtDNA).	UMLS:C3277376	hp.json	Multiple mtDNA deletions	http://purl.obolibrary.org/obo/HP_0003689		
HP:0001027	biolink:PhenotypicFeature	Soft, doughy skin	A skin texture that is unusually soft (and may feel silky), and has a malleable consistency resembling that of dough.	UMLS:C1849043	hp.json	Soft, doughy skin	http://purl.obolibrary.org/obo/HP_0001027		
HP:0003688	biolink:PhenotypicFeature	Cytochrome C oxidase-negative muscle fibers	An abnormally reduced activity of the enzyme cytochrome C oxidase in muscle tissue.	UMLS:C4021724	hp.json	Decreased activity of cytochrome C oxidase in muscle tissue|Cytochrome C oxidase-negative muscle fibres|Cytochrome c oxidase deficiency in skeletal muscle|Decreased skeletal muscle cytochrome c oxidase activity	http://purl.obolibrary.org/obo/HP_0003688		
UBERON:0005339	biolink:AnatomicalEntity	outflow tract pulmonary component		VHOG:0001395|MA:0000102|EHDAA2:0001359|EMAPA:17330|EHDAA:4401	hp.json		http://purl.obolibrary.org/obo/UBERON_0005339		
UBERON:0005338	biolink:AnatomicalEntity	outflow tract aortic component	An outflow tract that is part of a aorta.	EHDAA2:0001353|EMAPA:17329|VHOG:0001394|MA:0000101	hp.json		http://purl.obolibrary.org/obo/UBERON_0005338		
UBERON:0005337	biolink:AnatomicalEntity	outflow tract of ventricle	A ventricular outflow tract is a portion of either the left ventricle or right ventricle of the heart through which blood passes in order to enter the great arteries. The right ventricular outflow tract (RVOT) is an infundibular extension of the ventricular cavity which connects to the pulmonary artery. The left ventricular outflow tract (LVOT), which connects to the aorta, is nearly indistinguishable from the rest of the ventricle[WP].	XAO:0004140|FMA:13225|Wikipedia:Ventricular_outflow_tract	hp.json	ventricular outflow tract|ventricular outflow tract|outflow part of ventricle|heart ventricle outflow tract	http://purl.obolibrary.org/obo/UBERON_0005337		
HP:0003683	biolink:PhenotypicFeature	Large beaked nose		UMLS:C4025579	hp.json	Large beaked nose	http://purl.obolibrary.org/obo/HP_0003683		
HP:0003682	biolink:PhenotypicFeature	Variable progression rate	Applies to a disease manifestation that quickly increases in scope or severity with a rate that varies. For instance, progression may be slow in one time period and rapid in another.	UMLS:C1970284	hp.json		http://purl.obolibrary.org/obo/HP_0003682		
UBERON:0005334	biolink:AnatomicalEntity	oral lamina propria	A lamina propria that is part of a mucosa of oral region.	EMAPA:26947	hp.json	lamina propria of oral mucosa	http://purl.obolibrary.org/obo/UBERON_0005334		
HP:0003680	biolink:PhenotypicFeature	Nonprogressive	Applies to a disease manifestation that does not increase in scope or severity over the course of time, i.e., that does not worsen with age.	SNOMEDCT_US:702322003|UMLS:C3839460	hp.json	Non-progressive|Stationary|Nonprogressive disorder|Does not worsen|Nonprogressive course	http://purl.obolibrary.org/obo/HP_0003680		
UBERON:0005333	biolink:AnatomicalEntity	mammary bud	A bulb of epithelial cells that forms from the mammary placode that develops into the mammary gland.	EMAPA:35536	hp.json	lactiferous gland bud|mammary primordium|mammary gland bud|milk bud	http://purl.obolibrary.org/obo/UBERON_0005333		
UBERON:0005319	biolink:AnatomicalEntity	mesonephric collecting duct	The collecting duct is the final common path through which urine flows before entering the ureter and then emptying into the bladder[GO].	XAO:0000151|AAO:0010390	hp.json		http://purl.obolibrary.org/obo/UBERON_0005319		
UBERON:0005321	biolink:AnatomicalEntity	mesonephric smooth muscle tissue			hp.json		http://purl.obolibrary.org/obo/UBERON_0005321		
HP:0003698	biolink:PhenotypicFeature	Difficulty standing		SNOMEDCT_US:249902000|UMLS:C0241237	hp.json	Difficulty in standing|Standing instability	http://purl.obolibrary.org/obo/HP_0003698		
HP:0001036	biolink:PhenotypicFeature	Parakeratosis	Abnormal formation of the keratinocytes of the epidermis characterized by persistence of nuclei, incomplete formation of keratin, and moistness and swelling of the keratinocytes.	MSH:D010241|SNOMEDCT_US:200766001|SNOMEDCT_US:65068000|UMLS:C0030436	hp.json		http://purl.obolibrary.org/obo/HP_0001036		
HP:0003697	biolink:PhenotypicFeature	Scapuloperoneal amyotrophy	Muscular atrophy in the distribution of shoulder girdle and peroneal muscles.	UMLS:C1842162	hp.json	Scapuloperoneal atrophy	http://purl.obolibrary.org/obo/HP_0003697		
HP:0003696	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the 5th finger	Absence of the epiphysis located at the proximal end of the distal phalanx of the 5th finger.	UMLS:C4025577	hp.json	Absent end part of the outermost bone of the pinkie finger|Absent end part of the outermost bone of the little finger|Absent end part of the outermost bone of the pinky finger	http://purl.obolibrary.org/obo/HP_0003696		
HP:0001033	biolink:PhenotypicFeature	Facial flushing after alcohol intake		UMLS:C4025808	hp.json	Facial flushing after alcohol intake	http://purl.obolibrary.org/obo/HP_0001033		secondary_consequence
HP:0001034	biolink:PhenotypicFeature	Hypermelanotic macule	A hyperpigmented circumscribed area of change in normal skin color without elevation or depression of any size.	UMLS:C1842774	hp.json	Hyperpigmented spots|Hyperpigmented skin patches|Hyperpigmented macules	http://purl.obolibrary.org/obo/HP_0001034		
HP:0001039	biolink:PhenotypicFeature	Atheroeruptive xanthoma		UMLS:C4025807	hp.json		http://purl.obolibrary.org/obo/HP_0001039		
HP:0001038	biolink:PhenotypicFeature	Warfarin-induced skin necrosis		UMLS:C1867638	hp.json		http://purl.obolibrary.org/obo/HP_0001038		secondary_consequence
HP:0003690	biolink:PhenotypicFeature	Limb muscle weakness	Reduced strength and weakness of the muscles of the arms and legs.	UMLS:C0587246|SNOMEDCT_US:713514005	hp.json	Limb muscle weakness|Limb weakness	http://purl.obolibrary.org/obo/HP_0003690		
UBERON:0005328	biolink:AnatomicalEntity	mesonephric comma-shaped body	The mesonephric comma-shaped body is the precursor structure to the mesonephric S-shaped body that contributes to the morphogenesis of a nephron in the mesonephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005328		
UBERON:0005327	biolink:AnatomicalEntity	mesonephric glomerular epithelium	A mesonephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the mesonephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005327		
UBERON:0005326	biolink:AnatomicalEntity	mesonephric glomerulus vasculature	The mesonephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the mesonephric glomerulus[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005326		
UBERON:0005325	biolink:AnatomicalEntity	mesonephric glomerulus	The mesonephric glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the mature vertebrate kidney, or mesonephros[GO].	VHOG:0001238|XAO:0000146|EMAPA:30568|AAO:0010388	hp.json	glomerulus	http://purl.obolibrary.org/obo/UBERON_0005325		
HP:0003694	biolink:PhenotypicFeature	Late-onset proximal muscle weakness	Lack of strength of the proximal musculature occurring late in the clinical course.	UMLS:C4025578	hp.json		http://purl.obolibrary.org/obo/HP_0003694		
HP:0001031	biolink:PhenotypicFeature	Subcutaneous lipoma	The presence of subcutaneous lipoma.	UMLS:C1403035|NCIT:C3192	hp.json		http://purl.obolibrary.org/obo/HP_0001031		
HP:0001032	biolink:PhenotypicFeature	Absent distal interphalangeal creases	Absence of the distal interphalangeal flexion creases of the fingers.	UMLS:C1861349	hp.json	Distal finger flexion creases absent|Aplasia of the distal interphalangeal creases|Absence of skin creases over distal interphalangeal joints	http://purl.obolibrary.org/obo/HP_0001032		
HP:0003693	biolink:PhenotypicFeature	Distal amyotrophy	Muscular atrophy affecting muscles in the distal portions of the extremities.	UMLS:C1848736	hp.json	Amyotrophy of distal limb muscles|Muscle atrophy, distal|Distal muscle atrophy, upper and lower limbs|Distal amyotrophy, especially of the hands and feet|Distal muscle atrophy|Distal limb muscle atrophy|Distal muscle degeneration|Distal muscular atrophy|Distal muscle wasting	http://purl.obolibrary.org/obo/HP_0003693		
UBERON:0005323	biolink:AnatomicalEntity	mesonephric mesenchyme	Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros[GO].	XAO:0000291|EHDAA2:0001132|EMAPA:16745|AAO:0011062	hp.json		http://purl.obolibrary.org/obo/UBERON_0005323		pheno_slim
HP:0001030	biolink:PhenotypicFeature	Fragile skin	Skin that splits easily with minimal injury.	UMLS:C0241181|MEDDRA:10040851|SNOMEDCT_US:247427007	hp.json	Fragile skin|Skin fragility	http://purl.obolibrary.org/obo/HP_0001030		hposlim_core
UBERON:0005322	biolink:AnatomicalEntity	mesonephric nephron	A nephron that is part of a mesonephros.	ZFA:0005592|AAO:0010387|XAO:0000292	hp.json	stage IV nephron|nephron of mesonephros	http://purl.obolibrary.org/obo/UBERON_0005322		
HP:0003691	biolink:PhenotypicFeature	Scapular winging	Abnormal protrusion of the scapula away from the surface of the back.	MEDDRA:10067628|UMLS:C0240953|SNOMEDCT_US:17211005|UMLS:C4072849	hp.json	Winged shoulder blade|Scapular weakness|Winged scapulae|Winged scapulas|Scapula alata	http://purl.obolibrary.org/obo/HP_0003691		hposlim_core
HP:0001090	biolink:PhenotypicFeature	Abnormally large globe	Diffusely large eye (with megalocornea) without glaucoma.	UMLS:C4280603|UMLS:C1855852|UMLS:C0423221|SNOMEDCT_US:246920008	hp.json	Large eyes|Large of palpebral fissures|Large eyeballs|Megalophthalmos|Increased size of eyes|Increased size of palpebral fissures	http://purl.obolibrary.org/obo/HP_0001090		
HP:0025057	biolink:PhenotypicFeature	Abnormality of olfactory lobe morphology	A structural anomaly of the olfactory lobe, the structure within the brain that receives neural input from the nasal cavity and thereby processes the sense of smell.		hp.json		http://purl.obolibrary.org/obo/HP_0025057		
UBERON:0005398	biolink:AnatomicalEntity	female reproductive gland	A sex gland that is part of a female reproductive system.	MA:0000383|BTO:0000254	hp.json		http://purl.obolibrary.org/obo/UBERON_0005398		organ_slim|pheno_slim
HP:0025058	biolink:PhenotypicFeature	Hypothalamic atrophy	Partial or complete wasting (loss) of hypothalamus tissue that was once present.		hp.json	Atrophy of the hypothalamus	http://purl.obolibrary.org/obo/HP_0025058		
UBERON:0005397	biolink:AnatomicalEntity	brain arachnoid mater	An arachnoid mater that surrounds a brain.	FMA:83981|MA:0000814|NCIT:C49331|EMAPA:32661|VHOG:0000230	hp.json	brain arachnoid matter|arachnoidea mater encephali|cranial arachnoid mater|arachnoidea mater cranialis	http://purl.obolibrary.org/obo/UBERON_0005397		
UBERON:0005396	biolink:AnatomicalEntity	carotid artery segment	One of: the common carotid artery, or its branches, the external and internal carotid arteries.	ZFA:0000097|EMAPA:18609|Wikipedia:Carotid_artery|UMLS:C0007272|BTO:0000168|TAO:0000097|MA:0001925|OpenCyc:Mx4rvg7rcJwpEbGdrcN5Y29ycA|CALOHA:TS-0116|EHDAA:6385|EFO:0000818|VHOG:0000266|FMA:70504|GAID:478|SCTID:69105007|MESH:D002339|SCTID:362040006|galen:CarotidArtery|AAO:0010217|MAT:0000501|NCIT:C12687|EV:0100379	hp.json	carotid|subdivision of common carotid artery|carotid artery|common carotid arterial subdivision	http://purl.obolibrary.org/obo/UBERON_0005396		grouping_class|pheno_slim|efo_slim|vertebrate_core
HP:0025059	biolink:PhenotypicFeature	Splenic abscess	A circumscribed area of pus or necrotic debris in the parenchyma of the spleen.		hp.json		http://purl.obolibrary.org/obo/HP_0025059		
HP:0001088	biolink:PhenotypicFeature	Brushfield spots	The presence of whitish spots in a ring-like arrangement at the periphery of the iris.	SNOMEDCT_US:400960002|UMLS:C4280604|UMLS:C1303007	hp.json	Iris brushfield spots|Speckled iris	http://purl.obolibrary.org/obo/HP_0001088		hposlim_core
HP:0001089	biolink:PhenotypicFeature	Iris atrophy	Loss of iris tissue (atrophy)	UMLS:C0423319|SNOMEDCT_US:95709007	hp.json	Iris degeneration	http://purl.obolibrary.org/obo/HP_0001089		
HP:0001082	biolink:PhenotypicFeature	Cholecystitis	The presence of inflammatory changes in the gallbladder.	MSH:D002764|SNOMEDCT_US:76581006|UMLS:C0008325	hp.json	Gallbladder inflammation	http://purl.obolibrary.org/obo/HP_0001082		
HP:0001083	biolink:PhenotypicFeature	Ectopia lentis	Dislocation or malposition of the crystalline lens of the eye. A partial displacement (or dislocation) of the lens is described as a subluxation of the lens, while a complete displacement is termed luxation of the lens. A complete displacement occurs if the lens is completely outside the patellar fossa of the lens, either in the anterior chamber, in the vitreous, or directly on the retina. If the lens is partially displaced but still contained within the lens space, then it is termed subluxation.	MSH:D004479|SNOMEDCT_US:74969002|UMLS:C0013581|MSH:D007906|UMLS:C0023309	hp.json	Lens dislocation|Abnormality of lens position	http://purl.obolibrary.org/obo/HP_0001083		hposlim_core
HP:0025050	biolink:PhenotypicFeature	Elevated brain creatine level by MRS	An increase in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json	Elevated brain creatine level by magnetic resonance spectroscopy	http://purl.obolibrary.org/obo/HP_0025050		
HP:0001080	biolink:PhenotypicFeature	Biliary tract abnormality	An abnormality of the biliary tree.	MSH:D001660|UMLS:C0005424|UMLS:C0549613|SNOMEDCT_US:105997008	hp.json	Biliary tract disease	http://purl.obolibrary.org/obo/HP_0001080		
HP:0025051	biolink:PhenotypicFeature	Reduced brain creatine level by MRS	A decrease in the level of creatine in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json	Reduced brain creatine level by magnetic resonance spectroscopy|Low brain creatine phosphate	http://purl.obolibrary.org/obo/HP_0025051		
HP:0001081	biolink:PhenotypicFeature	Cholelithiasis	Hard, pebble-like deposits that form within the gallbladder.	SNOMEDCT_US:266474003|UMLS:C0008350|MSH:D002769	hp.json	Gallstones	http://purl.obolibrary.org/obo/HP_0001081		
HP:0025052	biolink:PhenotypicFeature	Abnormal brain N-acetyl aspartate level by MRS	A deviation from normal in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json	Abnormal brain N-acetyl aspartate level by magnetic resonance spectroscopy	http://purl.obolibrary.org/obo/HP_0025052		
HP:0025053	biolink:PhenotypicFeature	Elevated brain N-acetyl aspartate level by MRS	An increase in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json	Elevated brain N-acetyl aspartate level by magnetic resonance spectroscopy	http://purl.obolibrary.org/obo/HP_0025053		
HP:0001087	biolink:PhenotypicFeature	Developmental glaucoma	Glaucoma which forms during the early years of a child's life is called developmental or congenital glaucoma.	UMLS:C0020302|SNOMEDCT_US:204113001|SNOMEDCT_US:413728006|MSH:D006871	hp.json	Pediatric glaucoma|Childhood glaucoma|Paediatric glaucoma|Infantile glaucoma	http://purl.obolibrary.org/obo/HP_0001087		
HP:0001084	biolink:PhenotypicFeature	Corneal arcus	A hazy, grayish-white ring about 2 mm in width located close to but separated from the limbus (the corneoscleral junction). Corneal arcus generally occurs bilaterally, and is related to lipid deposition in the cornea. Corneal arcus can occur in elderly persons as a part of the aging process but may be associated with hypercholesterolemia in people under the age of 50 years.	SNOMEDCT_US:231925004|SNOMEDCT_US:231924000|MSH:D001112|UMLS:C0003742|SNOMEDCT_US:111522004|UMLS:C0339268	hp.json	Arcus lipoidis|Corneal annulus|Arcus juvenilis|Arcus senilis|Gerontoxon|Anterior embryotoxon	http://purl.obolibrary.org/obo/HP_0001084		
HP:0001085	biolink:PhenotypicFeature	Papilledema	Papilledema refers to edema (swelling) of the optic disc secondary to any factor which increases cerebral spinal fluid pressure.	SNOMEDCT_US:73221001|MSH:D010211|UMLS:C0030353|SNOMEDCT_US:423341008|SNOMEDCT_US:248487006	hp.json	Papillitis	http://purl.obolibrary.org/obo/HP_0001085		hposlim_core
UBERON:0005399	biolink:AnatomicalEntity	male reproductive gland	A sex gland that is part of a male reproductive system.	BTO:0000080|EMAPA:19285|MA:0000399	hp.json	accessory sex gland	http://purl.obolibrary.org/obo/UBERON_0005399		organ_slim|pheno_slim
CHEBI:29103	biolink:ChemicalSubstance	potassium(1+)	A monoatomic monocation obtained from potassium.	Gmelin:15203|PDBeChem:K|KEGG:C00238|CAS:24203-36-9|KEGG:D08403	hp.json	potassium(I) cation|POTASSIUM ION|potassium cation|potassium(1+)|K(+)|K(+)|K+|potassium(1+) ion	http://purl.obolibrary.org/obo/CHEBI_29103		3_STAR
CHEBI:29101	biolink:ChemicalSubstance	sodium(1+)	A monoatomic monocation obtained from sodium.	CAS:17341-25-2|Gmelin:15196|CAS:17341-25-2|KEGG:C01330|PDBeChem:NA	hp.json	sodium(1+)|Na+|sodium cation|sodium(1+) ion|sodium(I) cation|Na(+)|SODIUM ION|Na(+)	http://purl.obolibrary.org/obo/CHEBI_29101		3_STAR
HP:0025046	biolink:PhenotypicFeature	Reduced brain lactate level by MRS	A decrease in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json	Reduced brain lactate level by magnetic resonance spectroscopy	http://purl.obolibrary.org/obo/HP_0025046		
HP:0025047	biolink:PhenotypicFeature	Abnormal brain choline level by MRS	A deviation from normal in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json	Abnormal brain choline level by magnetic resonance spectroscopy	http://purl.obolibrary.org/obo/HP_0025047		
PR:000007856	biolink:Protein	gastrin	A protein that is a translation product of the human GAST gene or a 1:1 ortholog thereof.		hp.json	GAS|GAST	http://purl.obolibrary.org/obo/PR_000007856		
HP:0025048	biolink:PhenotypicFeature	Reduced brain choline level by MRS	An decrease in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json	Reduced brain choline level by magnetic resonance spectroscopy	http://purl.obolibrary.org/obo/HP_0025048		
HP:0001099	biolink:PhenotypicFeature	Fundus atrophy		UMLS:C2673929	hp.json		http://purl.obolibrary.org/obo/HP_0001099		
PR:000007857	biolink:Protein	erythroid transcription factor	A protein that is a translation product of the human GATA1 gene or a 1:1 ortholog thereof.		hp.json	NF-E1 DNA-binding protein|GATA-binding factor 1|GF-1|ERYF1|GATA1|GATA-1|GF1|Eryf1	http://purl.obolibrary.org/obo/PR_000007857		
HP:0025049	biolink:PhenotypicFeature	Abnormal brain creatine level by MRS			hp.json	Abnormal brain creatine level by magnetic resonance spectroscopy	http://purl.obolibrary.org/obo/HP_0025049		
UBERON:0005384	biolink:AnatomicalEntity	nasal cavity epithelium	An epithelium that lines the nasal cavity.	VHOG:0000501|CALOHA:TS-0656|EMAPA:17605|FMA:63140|NCIT:C49261|MA:0001324|EHDAA:6803|EHDAA2:0001227|UMLS:C1709151	hp.json	nasal mucosa|nasal epithelium	http://purl.obolibrary.org/obo/UBERON_0005384		pheno_slim
PR:000007858	biolink:Protein	endothelial transcription factor GATA-2	A protein that is a translation product of the human GATA2 gene or a 1:1 ortholog thereof.		hp.json	GATA-binding protein 2|GATA2	http://purl.obolibrary.org/obo/PR_000007858		
UBERON:0005383	biolink:AnatomicalEntity	caudate-putamen	Regional part of telencephalon in some species, e.g., rodent, equivalent to the dorsal striatum (caudate nucleus and putamen). Unlike the dorsal striatum of primates, for example, the caudoputamen is not split into separate nuclei by the fibers of the internal capsule. Rather, the internal capsule splits into fiber bundles which course through the structure.	BTO:0000212|EMAPA:19095|NLXANAT:100312|MBA:672|BAMS:CPu|BAMS:CP|BM:Tel-C-Pu|EFO:0001912|MA:0000893	hp.json	caudate putamen|caudateputamen|caudate-putamen|dorsal striatum|neostriatum|caudate putamen|caudoputamen|caudate putamen (striatum)|caudateputamen|striatum	http://purl.obolibrary.org/obo/UBERON_0005383		pheno_slim|efo_slim
UBERON:0005382	biolink:AnatomicalEntity	dorsal striatum	Dorsal components of the striatum comprising the caudate nucleus and the putamen, in species that have distinct nuclei; the caudoputamen in species which don't.	BAMS:STRd|BAMS:StrD|BTO:0004701|BAMS:Dorsal_striatum|FMA:77620|MBA:485|NLXANAT:1010001|EMAPA:36575|PBA:10081|MA:0002971	hp.json	caudoputamen|striatum dorsale|striatum dorsal region|corpus striatum|striated body|dorsal basal ganglion|dorsal basal ganglia	http://purl.obolibrary.org/obo/UBERON_0005382		
UBERON:0005381	biolink:AnatomicalEntity	dentate gyrus granule cell layer	Granule cell layer is also called the DG principal cell layer. This one of the three layers of dentate gyrus that lies deep to the molecular layer and is made of densely packed layer that is four to eight granule cells thick.	DMBA:16122|BAMS:sg|BAMS:DG-sg|FMA:83146|MBA:632|MA:0000946|BAMS:GrDG|BIRNLEX:4129|EMAPA:35276	hp.json	granular layer of the dentate gyrus|DG granule cell layer|granular layer of dentate gyrus|stratum granulare gyri dentati|dentate gyrus, granule cell layer	http://purl.obolibrary.org/obo/UBERON_0005381		pheno_slim
HP:0001093	biolink:PhenotypicFeature	Optic nerve dysplasia	The presence of developmental dysplasia of the optic nerve.	UMLS:C2676026	hp.json		http://purl.obolibrary.org/obo/HP_0001093		
CHEBI:78113	biolink:ChemicalSubstance	fatty acid anion 3:0	Any saturated fatty acid anion containing 3 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.		hp.json	fatty acid 3:0	http://purl.obolibrary.org/obo/CHEBI_78113		3_STAR
HP:0001094	biolink:PhenotypicFeature	Iridocyclitis	A type of anterior uveitis, in which there is Inflammation of the iris and the ciliary body.	MSH:D015863|SNOMEDCT_US:77971008|UMLS:C0022073	hp.json		http://purl.obolibrary.org/obo/HP_0001094		
NCBITaxon:7586	biolink:OrganismalEntity	Echinodermata			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_7586		
HP:0025040	biolink:PhenotypicFeature	Thalamic edema	Swelling within the thalamus due to the accumulation of fluid.		hp.json	Oedema of the thalamus|Edema of the thalamus|Thalamic oedema	http://purl.obolibrary.org/obo/HP_0025040		
HP:0025041	biolink:PhenotypicFeature	Thalamic calcification	Calcium deposition in the thalamus.		hp.json		http://purl.obolibrary.org/obo/HP_0025041		
HP:0001092	biolink:PhenotypicFeature	Absent lacrimal punctum	No identifiable superior and/or inferior lacrimal punctum.	SNOMEDCT_US:204208005|UMLS:C1867060|SNOMEDCT_US:253217007|UMLS:C0344509|MSH:C566703	hp.json	Agenesis of the lacrimal punctum|Absent lacrimal puncta|Lacrimal puncta aplasia|Absent lacrimal gland puncta|Aplasia of lacrimal puncta|Lacrimal punctum, absence|Absent lacrimal openings	http://purl.obolibrary.org/obo/HP_0001092		hposlim_core
HP:0001097	biolink:PhenotypicFeature	Keratoconjunctivitis sicca	Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids.	UMLS:C0043349|MSH:D007638|MSH:D014985|UMLS:C0013238|UMLS:C2930821|UMLS:C0022575|SNOMEDCT_US:363677007|MSH:D015352|MSH:C531719|SNOMEDCT_US:46152009|SNOMEDCT_US:302896008	hp.json	Dry eyes|Keratitis sicca|Dry eye syndrome|Xerophthalmia	http://purl.obolibrary.org/obo/HP_0001097		hposlim_core
HP:0025042	biolink:PhenotypicFeature	Abnormality of mesenteric lymph nodes	A morphological anomaly of lymph nodes in the mesenteric root or throughout the mesentery.		hp.json		http://purl.obolibrary.org/obo/HP_0025042		
HP:0025043	biolink:PhenotypicFeature	Enlarged mesenteric lymph node	Increase in size of one or more mesenteric lymph nodes.		hp.json		http://purl.obolibrary.org/obo/HP_0025043		
HP:0001098	biolink:PhenotypicFeature	Abnormal fundus morphology	Any structural abnormality of the fundus of the eye.	UMLS:C4025804	hp.json	Abnormality of the fundus	http://purl.obolibrary.org/obo/HP_0001098		
HP:0025044	biolink:PhenotypicFeature	Lung abscess	A circumscribed area of pus or necrotic debris in lung parenchyma, which leads to a cavity, and after formation of bronchopulmonary fistula, can manifest as an air-fluid level inside the cavity.		hp.json		http://purl.obolibrary.org/obo/HP_0025044		
CHEBI:78116	biolink:ChemicalSubstance	fatty acid anion 6:0	Any saturated fatty acid anion containing 6 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.		hp.json	fatty acid 6:0	http://purl.obolibrary.org/obo/CHEBI_78116		3_STAR
HP:0001095	biolink:PhenotypicFeature	Hypertensive retinopathy		UMLS:C0152132|SNOMEDCT_US:6962006|MSH:D058437	hp.json		http://purl.obolibrary.org/obo/HP_0001095		secondary_consequence
UBERON:0005389	biolink:AnatomicalEntity	transparent eye structure	A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array.		hp.json	lens	http://purl.obolibrary.org/obo/UBERON_0005389		grouping_class
HP:0025045	biolink:PhenotypicFeature	Abnormal brain lactate level by MRS	A deviation from normal of the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json	Abnormal lactate level by magnetic resonance spectroscopy	http://purl.obolibrary.org/obo/HP_0025045		
HP:0001096	biolink:PhenotypicFeature	Keratoconjunctivitis	Inflammation of the cornea and conjunctiva.	SNOMEDCT_US:88151007|MSH:D007637|UMLS:C0022573	hp.json		http://purl.obolibrary.org/obo/HP_0001096		hposlim_core
CHEBI:78115	biolink:ChemicalSubstance	fatty acid anion 4:0	Any saturated fatty acid anion containing 4 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.		hp.json	fatty acid 4:0	http://purl.obolibrary.org/obo/CHEBI_78115		3_STAR
UBERON:0005388	biolink:AnatomicalEntity	photoreceptor array	An array of photoreceptors and any supporting cells found in an eye.	FBbt:00004200	hp.json	light-sensitive tissue	http://purl.obolibrary.org/obo/UBERON_0005388		
CHEBI:32727	biolink:ChemicalSubstance	tryptophanate	An alpha-amino-acid anion that is the conjugate base of tryptophan, arising from deprotonation of the carboxy group.	Gmelin:331342|Reaxys:4144998|Beilstein:4144997	hp.json	trp(-)|tryptophan anion|tryptophanate|2-amino-3-(1H-indol-3-yl)propanoate	http://purl.obolibrary.org/obo/CHEBI_32727		3_STAR
CHEBI:32728	biolink:ChemicalSubstance	tryptophanium	An alpha-amino-acid cation that is the conjugate acid of tryptophan, arising from protonation of the alpha-amino group.		hp.json	tryptophan cation|tryptophanium|Htrp(+)|1-carboxy-2-(1H-indol-3-yl)ethanaminium	http://purl.obolibrary.org/obo/CHEBI_32728		3_STAR
HP:0025035	biolink:PhenotypicFeature	Abnormal proerythroblast morphology	Anomalous form of the proerythroblast, i.e., the immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.		hp.json		http://purl.obolibrary.org/obo/HP_0025035		
UBERON:0005375	biolink:AnatomicalEntity	spinal cord ventral column	The area of white matter of the spinal cord located on either side of the ventral (anterior) medial fissure.	EV:0100326|MA:0002751|VHOG:0001622	hp.json	spinal cord anterior column|ventral column|anterior column	http://purl.obolibrary.org/obo/UBERON_0005375		pheno_slim
HP:0001069	biolink:PhenotypicFeature	Episodic hyperhidrosis	Intermittent episodes of abnormally increased perspiration.	UMLS:C1857171	hp.json	Sporadic excessive sweating|Hyperhidrosis, episodic	http://purl.obolibrary.org/obo/HP_0001069		
HP:0025037	biolink:PhenotypicFeature	Hypothalamic gliosis	Focal proliferation of glial cells in the hypothalamus.		hp.json		http://purl.obolibrary.org/obo/HP_0025037		
UBERON:0005373	biolink:AnatomicalEntity	spinal cord dorsal column	The wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception.	NCIT:C33355|MBA:514|VHOG:0001623|BAMS:dc|MA:0002749|UMLS:C0458459|EV:0100317	hp.json	dorsal columns|dorsal column of spinal cord|dorsal column system|posterior column|spinal cord posterior column|dorsal column	http://purl.obolibrary.org/obo/UBERON_0005373		pheno_slim
HP:0001067	biolink:PhenotypicFeature	Neurofibromas	The presence of multiple cutaneous neurofibromas.	MSH:D017253|NCIT:C3272|UMLS:C0162678|SNOMEDCT_US:19133005|SNOMEDCT_US:81669005	hp.json	Neurofibromata|Neurofibromatosis|multiple neurofibromas	http://purl.obolibrary.org/obo/HP_0001067		
HP:0025038	biolink:PhenotypicFeature	Intratesticular abscess	A collection of pus within a testicle. Ultrasonographic features include shaggy, irregular walls, intratesticular location, low-level internal echoes, and occasionally, hypervascular margins.		hp.json	Testicular abscess	http://purl.obolibrary.org/obo/HP_0025038		
CHEBI:78121	biolink:ChemicalSubstance	fatty acid anion 14:0	Any saturated fatty acid anion containing 14 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.		hp.json	fatty acid 14:0	http://purl.obolibrary.org/obo/CHEBI_78121		3_STAR
HP:0025039	biolink:PhenotypicFeature	Basal ganglia edema	Swelling within the basal ganglia due to the accumulation of fluid.		hp.json	Edema of the basal ganglia|Oedema of the basal ganglia|Basal ganglia oedema	http://purl.obolibrary.org/obo/HP_0025039		
CHEBI:78125	biolink:ChemicalSubstance	fatty acid anion 18:0	Any saturated fatty acid anion containing 18 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.		hp.json	fatty acid 18:0	http://purl.obolibrary.org/obo/CHEBI_78125		3_STAR
HP:0001060	biolink:PhenotypicFeature	Axillary pterygium	Presence of a cutaneous membrane (flap) in the armpit.	UMLS:C1844738	hp.json	Axillary pterygia	http://purl.obolibrary.org/obo/HP_0001060		
CHEBI:17126	biolink:ChemicalSubstance	carnitine	An amino-acid betaine that is butanoate substituted with a hydroxy group at position C-3 and a trimethylammonium group at C-4.	Patent:US4315944|Reaxys:1866665|Beilstein:1866665|PMID:23868375|KEGG:C00487|PMID:22770225|CAS:461-06-3|DrugBank:DB02648|Patent:US4255449|Wikipedia:Carnitine|MetaCyc:DL-CARNITINE	hp.json	D,L-carnitine|carnitine|3-hydroxy-4-(trimethylammonio)butanoate	http://purl.obolibrary.org/obo/CHEBI_17126		3_STAR
HP:0001061	biolink:PhenotypicFeature	Acne	A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts).	UMLS:C0702166|SNOMEDCT_US:11381005|MEDDRA:10000496	hp.json	Acne|Breaking out	http://purl.obolibrary.org/obo/HP_0001061		hposlim_core
CHEBI:78123	biolink:ChemicalSubstance	fatty acid anion 16:0	Any saturated fatty acid anion containing 16 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3.		hp.json	fatty acid 16:0	http://purl.obolibrary.org/obo/CHEBI_78123		3_STAR
HP:0025030	biolink:PhenotypicFeature	Enteric neuronal degeneration	Deterioration of enteric neurons with impairment of enteric neuronal structure. Typical neuropathological findings include qualitative (e.g., neuronal swelling, intranuclear inclusions, axonal degeneration) and quantitative (e.g., reduction in the number of neurons) abnormalities of the enteric neurons.		hp.json	Degenerative enteric neuropathy	http://purl.obolibrary.org/obo/HP_0025030		
HP:0025031	biolink:PhenotypicFeature	Abnormality of the digestive system			hp.json		http://purl.obolibrary.org/obo/HP_0025031		
HP:0001065	biolink:PhenotypicFeature	Striae distensae	Thinned, erythematous, depressed bands of atrophic skin. Initially, striae appear as flattened and thinned, pinkish linear regions of the skin. Striae tend to enlarge in length and become reddish or purplish. Later, striae tend to appear as white, depressed bands that are parallel to the lines of skin tension. Striae distensae occur most often in areas that have been subject to distension such as the lower back, buttocks, thighs, breast, abdomen, and shoulders.	SNOMEDCT_US:201067006|UMLS:C0152459|MEDDRA:10040925|SNOMEDCT_US:201066002|MSH:D057896|SNOMEDCT_US:47212006	hp.json	Purplish striae|Stretch marks|Striae cutis distensae|Striae|Striae atrophicae	http://purl.obolibrary.org/obo/HP_0001065		hposlim_core
HP:0025032	biolink:PhenotypicFeature	Abnormality of digestive system physiology	A functional anomaly of the digestive system.		hp.json		http://purl.obolibrary.org/obo/HP_0025032		
HP:0025033	biolink:PhenotypicFeature	Abnormality of digestive system morphology	A structural anomaly of the digestive system.		hp.json		http://purl.obolibrary.org/obo/HP_0025033		
HP:0001062	biolink:PhenotypicFeature	Atypical nevus	A large pigmented lesion measuring 5-15 mm in diameter with irregular, notched, and ill defined border and with color that may range from tan to dark brown to pink.	MSH:D004416|UMLS:C0205748|SNOMEDCT_US:254818000|SNOMEDCT_US:61814002	hp.json	Atypical mole|Dysplastic Nevus	http://purl.obolibrary.org/obo/HP_0001062		
CHEBI:17120	biolink:ChemicalSubstance	hexanoate	A short-chain fatty acid anion that is the conjugate base of hexanoic acid (also known as caproic acid).	Beilstein:3601453|Gmelin:326340|KEGG:C01585|CAS:151-33-7|ECMDB:ECMDB21229|MetaCyc:HEXANOATE	hp.json	hexanoate|pentylformate|n-hexoate|1-hexanoate|1-pentacarboxylate|hexoate|nPnCO2 anion|hexanoate|butylacetate|n-hexanoate|pentanecarboxylate|CH3-[CH2]4-COO(-)|1-pentanecarboxylate|hexylate|caproate|n-hexylate|capronate|n-caproate	http://purl.obolibrary.org/obo/CHEBI_17120		3_STAR
HP:0025034	biolink:PhenotypicFeature	Abnormal morphology of erythroid progenitor cell	Abnormal form of the progenitor cells committed to the erythroid lineage.		hp.json		http://purl.obolibrary.org/obo/HP_0025034		
HP:0001063	biolink:PhenotypicFeature	Acrocyanosis	Bluish discoloration of the skin of the hands or feet.	UMLS:C0221347|SNOMEDCT_US:25003006	hp.json	Persistent blue colour of hands or feet|Persistent blue color of hands or feet	http://purl.obolibrary.org/obo/HP_0001063		
HP:0025024	biolink:PhenotypicFeature	Megarectum	An abnormal dilation of the rectum. There is a large filled rectum as a result of underlying innervation or muscular abnormalities, which remains after disimpaction of the rectum.		hp.json		http://purl.obolibrary.org/obo/HP_0025024		
HP:0025025	biolink:PhenotypicFeature	Rectovestibular fistula	A congenital malformation characterized by an abnormal connection (fistula) between the rectum and the vulval vestibule, at the lower aspect of the vaginal opening.		hp.json	Vestibular fistula	http://purl.obolibrary.org/obo/HP_0025025		
HP:0025026	biolink:PhenotypicFeature	H-type rectovestibular fistula	Rectovestibular fistula with a normal anus is known as H-type fistula or double termination of the alimentary tract.		hp.json		http://purl.obolibrary.org/obo/HP_0025026		
UBERON:0005363	biolink:AnatomicalEntity	inferior vagus X ganglion	The large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve).	EFO:0002516|EMAPA:17155|FMA:6230|EHDAA2:0004622|VHOG:0000685|MA:0001082|MESH:D009620	hp.json	ganglion inferius nervi vagi|vagus nerve nodose ganglion|vagus nerve inferior ganglion|ganglion inferius (nervus vagus)|vagus X inferior ganglion|ganglion inferius nervus vagi|tenth cranial nerve nodose ganglion|inferior vagus X|nodose ganglion|inferior ganglion of vagus|inferior vagus ganglion|ganglion nodosum|inferior ganglion of vagus nerve|nodose ganglia	http://purl.obolibrary.org/obo/UBERON_0005363		pheno_slim|efo_slim
UBERON:0005362	biolink:AnatomicalEntity	vagus X ganglion	The group of sensory neuron cell bodies associated with the vagus nerve.	SCTID:244452001|Wikipedia:Vagus_ganglion|ZFA:0007067|TAO:0007067|MA:0001081|VHOG:0000684|EMAPA:16798|FMA:53472	hp.json	right glossopharyngeal ganglion|vagus X|ganglion of vagus nerve|vagus neural ganglion|vagus ganglion|vagal ganglion|gX	http://purl.obolibrary.org/obo/UBERON_0005362		pheno_slim
HP:0025027	biolink:PhenotypicFeature	Osteoma cutis	The term osteoma refers to the anomalous presence of ossification (bone formation) in the interior of the dermis or epidermis. The dermal or subcutaneous bone formation presents as stony hard nodules. The osteomata appear as irregular, hardened small nodules that are well circumscribed and generally of the same color as the skin.		hp.json	Osteomatosis|Miliary osteoma|Cutaneous osteosis	http://purl.obolibrary.org/obo/HP_0025027		
HP:0025028	biolink:PhenotypicFeature	Abnormality of enteric nervous system morphology	A structural anomaly of nerves of the enteric nervous system.		hp.json		http://purl.obolibrary.org/obo/HP_0025028		
HP:0025029	biolink:PhenotypicFeature	Abnormality of enteric neuron morphology			hp.json		http://purl.obolibrary.org/obo/HP_0025029		
HP:0001071	biolink:PhenotypicFeature	Angiokeratoma corporis diffusum		MSH:D000795|SNOMEDCT_US:124464003|UMLS:C0002986|SNOMEDCT_US:16652001	hp.json	Fabry syndrome	http://purl.obolibrary.org/obo/HP_0001071		
HP:0001072	biolink:PhenotypicFeature	Thickened skin	Laminar thickening of skin.	MEDDRA:10040936|UMLS:C0334008|SNOMEDCT_US:69943009|SNOMEDCT_US:17417006|UMLS:C4020878	hp.json	Thickened skin|Diffusely thickened skin|Pachydermia|Thick skin	http://purl.obolibrary.org/obo/HP_0001072		hposlim_core
CHEBI:17113	biolink:ChemicalSubstance	erythritol	The meso-diastereomer of butane-1,2,3,4-tetrol.	PMID:17979222|Reaxys:1735878|HMDB:HMDB0002994|PMID:25108762|CAS:149-32-6|PMID:19632091|PMID:24643482|KEGG:C00503|PMID:18369603|PMID:9862657|CAS:149-32-6|PMID:163226|CAS:149-32-6|PMID:17336832|Gmelin:82499|PMID:22770225|PMID:23574577|PMID:12639570|PMID:23890177|Beilstein:1719753|PDBeChem:MRY|PMID:16901854|DrugBank:DB04481|Wikipedia:Erythritol|KNApSAcK:C00001161|MetaCyc:ERYTHRITOL|PMID:23421980	hp.json	mesoerythritol|(2R,3S)-butane-1,2,3,4-tetrol|Phycitol|erythritol|Erythrite|Phycite|L-erythritol|erythro-tetritol|MESO-ERYTHRITOL|Erythritol|Erythrol|Erythrit|meso-erythritol	http://purl.obolibrary.org/obo/CHEBI_17113		3_STAR
HP:0001070	biolink:PhenotypicFeature	Mottled pigmentation	Patchy and irregular skin pigmentation.	UMLS:C0860439|UMLS:C4020879	hp.json	Mottled skin coloring|Stippled pigmentation|Mottled skin colouring	http://purl.obolibrary.org/obo/HP_0001070		
HP:0025020	biolink:PhenotypicFeature	Elevated prostate-specific antigen level	An increased concentration of prostate specific antigen (PSA) in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025020		
HP:0001075	biolink:PhenotypicFeature	Atrophic scars	Scars that form a depression compared to the level of the surrounding skin because of damage to the collagen, fat or other tissues below the skin.	UMLS:C0162154|SNOMEDCT_US:409766009|SNOMEDCT_US:239172000	hp.json	Sunken or indented skin due to damage|Thin, atrophic scars	http://purl.obolibrary.org/obo/HP_0001075		hposlim_core
HP:0025021	biolink:PhenotypicFeature	Abnormal erythrocyte sedimentation rate	A deviation from normal range of the erythrocyte sedimentation rate (ESR), a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.		hp.json	Abnormal Westergren sedimentation rate|Abnormal ESR	http://purl.obolibrary.org/obo/HP_0025021		
HP:0001076	biolink:PhenotypicFeature	Glabellar hemangioma		UMLS:C1854408	hp.json	Glabellar capillary hemangioma	http://purl.obolibrary.org/obo/HP_0001076		
HP:0001073	biolink:PhenotypicFeature	Cigarette-paper scars	Thin (atrophic) and wide scars.	UMLS:C1851828	hp.json	Cigarette paper scarring|Cigarette-paper scars	http://purl.obolibrary.org/obo/HP_0001073		hposlim_core
HP:0025022	biolink:PhenotypicFeature	Decreased erythrocyte sedimentation rate	A reduced erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling.		hp.json	Low ESR|Decreased ESR	http://purl.obolibrary.org/obo/HP_0025022		
HP:0025023	biolink:PhenotypicFeature	Rectal atresia	A developmental defect resulting in complete obliteration of the lumen of the rectum. That is, there is an abnormal closure, or atresia of the tubular structure of the rectum.		hp.json	Atresia of the rectum	http://purl.obolibrary.org/obo/HP_0025023		
UBERON:0005366	biolink:AnatomicalEntity	olfactory lobe	The lobe at the anterior part of each cerebral hemisphere, responsible for olfactory functions.	EHDAA:5480|MA:0002413|EHDAA2_RETIRED:0001294|EFO:0000108|NCIT:C33204|UMLS:C0178780|VHOG:0000833|MIAA:0000116|EMAPA:17778|BTO:0001362	hp.json		http://purl.obolibrary.org/obo/UBERON_0005366		pheno_slim|efo_slim
HP:0001074	biolink:PhenotypicFeature	Atypical nevi in non-sun exposed areas		UMLS:C4021837	hp.json		http://purl.obolibrary.org/obo/HP_0001074		
GO:0031507	biolink:BiologicalProcess	heterochromatin assembly	An epigenetic gene silencing mechanism that involves the assembly of chromatin into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.		hp.json	establishment of heterochromatin architecture involved in chromatin silencing at pericentric region|heterochromatin formation|heterochromatin assembly involved in chromatin silencing|establishment of heterochromatin architecture|heterochromatin formation involved in chromatin silencing at pericentric region|chromatin-mediated silencing|heterochromatic silencing|establishment of heterochromatic silencing|transcriptional gene silencing|TGS|heterochromatin formation involved in chromatin silencing|heterochromatin assembly involved in chromatin silencing at centromere outer repeat region|chromatin silencing|establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region|heterochromatin maintenance|heterochromatin formation involved in chromatin silencing at centromere outer repeat region|heterochromatin assembly involved in chromatin silencing at pericentric region|establishment of chromatin silencing	http://purl.obolibrary.org/obo/GO_0031507		
GO:0006549	biolink:BiologicalProcess	isoleucine metabolic process	The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.		hp.json	isoleucine metabolism	http://purl.obolibrary.org/obo/GO_0006549		
GO:0031503	biolink:BiologicalProcess	protein-containing complex localization	A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.		hp.json	cellular protein complex localization|cellular protein-containing complex localization|protein complex localization|establishment and maintenance of protein complex localization|establishment and maintenance of cellular protein complex localization|cellular protein complex localisation|protein complex localisation	http://purl.obolibrary.org/obo/GO_0031503		
GO:0006547	biolink:BiologicalProcess	histidine metabolic process	The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.	Wikipedia:Histidine	hp.json	histidine metabolism	http://purl.obolibrary.org/obo/GO_0006547		
GO:0006544	biolink:BiologicalProcess	glycine metabolic process	The chemical reactions and pathways involving glycine, aminoethanoic acid.		hp.json	glycine metabolism	http://purl.obolibrary.org/obo/GO_0006544		
GO:0006541	biolink:BiologicalProcess	glutamine metabolic process	The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.		hp.json	glutamine metabolism	http://purl.obolibrary.org/obo/GO_0006541		
HP:0003621	biolink:PhenotypicFeature	Juvenile onset	Onset of signs or symptoms of disease between the age of 5 and 15 years.	UMLS:C4025588	hp.json	Signs and symptoms begin before 15 years of age	http://purl.obolibrary.org/obo/HP_0003621		
PATO:0001294	biolink:NamedThing	radiation reflective quality			hp.json		http://purl.obolibrary.org/obo/PATO_0001294		
HP:0003623	biolink:PhenotypicFeature	Neonatal onset	Onset of signs or symptoms of disease within the first 28 days of life.	UMLS:C1855106	hp.json	Onset in first weeks of life|Onset in neonatal period|Neonatal onset	http://purl.obolibrary.org/obo/HP_0003623		
PATO:0001297	biolink:NamedThing	reflectivity			hp.json		http://purl.obolibrary.org/obo/PATO_0001297		
PATO:0001291	biolink:NamedThing	electromagnetic (EM) radiation quality			hp.json		http://purl.obolibrary.org/obo/PATO_0001291		
PATO:0001292	biolink:NamedThing	full-spectrum EM radiation quality			hp.json		http://purl.obolibrary.org/obo/PATO_0001292		
GO:0006558	biolink:BiologicalProcess	L-phenylalanine metabolic process	The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.		hp.json	phenylalanine metabolic process|phenylalanine metabolism|L-phenylalanine metabolism	http://purl.obolibrary.org/obo/GO_0006558		
GO:0006555	biolink:BiologicalProcess	methionine metabolic process	The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.	UM-BBD_pathwayID:met	hp.json	methionine and threonine metabolism|methionine metabolism|methionine and threonine metabolic process	http://purl.obolibrary.org/obo/GO_0006555		
GO:0006553	biolink:BiologicalProcess	lysine metabolic process	The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid.	Wikipedia:Lysine	hp.json	lysine metabolism	http://purl.obolibrary.org/obo/GO_0006553		
HP:0003639	biolink:PhenotypicFeature	Elevated urinary epinephrine	An increased concentration of adrenaline in the urine.	UMLS:C1868393	hp.json	Increased urinary epinephrine	http://purl.obolibrary.org/obo/HP_0003639		
GO:0006551	biolink:BiologicalProcess	leucine metabolic process	The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid.		hp.json	leucine metabolism	http://purl.obolibrary.org/obo/GO_0006551		
HP:0003637	biolink:PhenotypicFeature	Reduced 4-Hydroxyphenylpyruvate dioxygenase level	An abnormal reduction in 4-hydroxyphenylpyruvate dioxygenase level.	UMLS:C4025587	hp.json	Reducted HPPD activity	http://purl.obolibrary.org/obo/HP_0003637		
HP:0003635	biolink:PhenotypicFeature	Loss of subcutaneous adipose tissue in limbs	Loss (disappearance) of previously present subcutaneous fat tissue in arm or leg.	UMLS:C1837764	hp.json	Loss of subcutaneous adipose tissue from extremities|Loss of fat tissue below the skin in limbs	http://purl.obolibrary.org/obo/HP_0003635		hposlim_core
HP:0003634	biolink:PhenotypicFeature	Amyoplasia	Congenital lack of development of the muscles, which are then replaced by a mixture of dense fat and fibrous tissue.	UMLS:C0432185|SNOMEDCT_US:205532005	hp.json	Absent muscles since birth|Congenital absence of muscles	http://purl.obolibrary.org/obo/HP_0003634		
BSPO:0001101	biolink:NamedThing	in deep part of	X superficial part of Y <=> if Y is subdivided into two superficial and deep portions, X is part of the deep portion.	BSPO:0001101	hp.json		http://purl.obolibrary.org/obo/BSPO_0001101		
BSPO:0001106	biolink:NamedThing	proximalmost part of	X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y	BSPO:0001106	hp.json		http://purl.obolibrary.org/obo/BSPO_0001106		
GO:0006525	biolink:BiologicalProcess	arginine metabolic process	The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.	Wikipedia:Arginine	hp.json	arginine metabolism	http://purl.obolibrary.org/obo/GO_0006525		
GO:0006520	biolink:BiologicalProcess	cellular amino acid metabolic process	The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.		hp.json	cellular amino acid and derivative metabolic process|amino acid and derivative metabolism|cellular amino acid metabolism|amino acid metabolic process	http://purl.obolibrary.org/obo/GO_0006520		goslim_yeast|goslim_generic|prokaryote_subset|goslim_pombe|goslim_pir|goslim_drosophila|goslim_chembl|goslim_aspergillus
HP:0003607	biolink:PhenotypicFeature	4-hydroxyphenylacetic aciduria	Increased concentration of 4-hydroxyphenylacetic acid in the urine.	UMLS:C1848680|MSH:C535315	hp.json	Elevated urine 4-hydroxyphenylacetic acid level	http://purl.obolibrary.org/obo/HP_0003607		
GO:0006521	biolink:BiologicalProcess	regulation of cellular amino acid metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.		hp.json	regulation of amino acid metabolism	http://purl.obolibrary.org/obo/GO_0006521		
HP:0003606	biolink:PhenotypicFeature	Absent urinary urothione	Lack of urothione (the urinary metabolite of molybdenum cofactor) in the urine.	UMLS:C4025591	hp.json		http://purl.obolibrary.org/obo/HP_0003606		
BSPO:0001107	biolink:NamedThing	immediately deep to	This relation holds when both the deep_to and ajdacent_to relationship similarly hold.	BSPO:0001107	hp.json		http://purl.obolibrary.org/obo/BSPO_0001107		
BSPO:0001108	biolink:NamedThing	distalmost part of	X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y	BSPO:0001108	hp.json		http://purl.obolibrary.org/obo/BSPO_0001108		
HP:0003609	biolink:PhenotypicFeature	Foam cells with lamellar inclusion bodies	The presence of foam cells that contain lamellar inclusion bodies.	UMLS:C4025590	hp.json		http://purl.obolibrary.org/obo/HP_0003609		
UBERON:0007914	biolink:AnatomicalEntity	bone of craniocervical region	A bone that is part of a craniocervical region.	MA:0000569|EMAPA:37245	hp.json	head or neck bone|cranial bone	http://purl.obolibrary.org/obo/UBERON_0007914		
BSPO:0001113	biolink:NamedThing	preaxialmost part of		BSPO:0001113	hp.json		http://purl.obolibrary.org/obo/BSPO_0001113		
GO:0006537	biolink:BiologicalProcess	glutamate biosynthetic process	The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid.		hp.json	glutamate biosynthesis, using glutamate synthase (NADPH)|glutamate biosynthetic process, using glutamate synthase (NADPH)|glutamate anabolism|glutamate biosynthesis|glutamic acid biosynthetic process|glutamic acid biosynthesis|glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)|glutamate synthesis|glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)|glutamate formation	http://purl.obolibrary.org/obo/GO_0006537		
GO:0006536	biolink:BiologicalProcess	glutamate metabolic process	The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.	Wikipedia:Glutamic_acid	hp.json	glutamate metabolism|glutamic acid metabolism|glutamic acid metabolic process	http://purl.obolibrary.org/obo/GO_0006536		
GO:0006534	biolink:BiologicalProcess	cysteine metabolic process	The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.	Wikipedia:Cysteine_metabolism	hp.json	cysteine metabolism	http://purl.obolibrary.org/obo/GO_0006534		
BSPO:0001115	biolink:NamedThing	postaxialmost part of		BSPO:0001115	hp.json		http://purl.obolibrary.org/obo/BSPO_0001115		
HP:0003616	biolink:PhenotypicFeature	Premature separation of centromeric heterochromatin		UMLS:C1849316	hp.json		http://purl.obolibrary.org/obo/HP_0003616		
HP:0003610	biolink:PhenotypicFeature	Fibroblast metachromasia	Increased cytoplasmic staining of fibroblasts with toluidine blue.	UMLS:C1835008	hp.json		http://purl.obolibrary.org/obo/HP_0003610		
HP:0003614	biolink:PhenotypicFeature	Trimethylaminuria	Increased concentration of trimethylamine in the urine.	SNOMEDCT_US:237959005|UMLS:C0342739|MSH:C536561	hp.json	High urine trimethylamine levels	http://purl.obolibrary.org/obo/HP_0003614		
HP:0003613	biolink:PhenotypicFeature	Antiphospholipid antibody positivity	The presence of circulating autoantibodies to phospholipids.	UMLS:C4019436	hp.json	Phospholipid antibody positivity|Antiphospholipid antibody|Antiphospholipid antibodies	http://purl.obolibrary.org/obo/HP_0003613		
HP:0003612	biolink:PhenotypicFeature	Positive ferric chloride test	If positive, the ferric chloride test indicates an increased concentration of phenols in the urine or blood.	UMLS:C4025589	hp.json	Positive FeCl3 test	http://purl.obolibrary.org/obo/HP_0003612		
IAO:0000700	biolink:NamedThing	has ontology root term		IAO:0000700	hp.json		http://purl.obolibrary.org/obo/IAO_0000700		
UBERON:0005309	biolink:AnatomicalEntity	pronephric nephron	A pronephric nephron is the functional unit of the pronephros[GO].	AAO:0011091|XAO:0000285	hp.json		http://purl.obolibrary.org/obo/UBERON_0005309		
OBO:GOREL_0002003	biolink:NamedThing	results_in_distribution_of		GOREL:0002003	hp.json		http://purl.obolibrary.org/obo/GOREL_0002003		
HP:0001008	biolink:PhenotypicFeature	Accumulation of melanosomes in melanocytes		UMLS:C1843389	hp.json		http://purl.obolibrary.org/obo/HP_0001008		
HP:0001009	biolink:PhenotypicFeature	Telangiectasia	Telangiectasias refer to small dilated blood vessels located near the surface of the skin or mucous membranes, measuring between 0.5 and 1 millimeter in diameter. Telangiectasia are located especially on the tongue, lips, palate, fingers, face, conjunctiva, trunk, nail beds, and fingertips.	SNOMEDCT_US:112641009|SNOMEDCT_US:247479008|MSH:D013684|UMLS:C0039446|UMLS:C1138421	hp.json	Cutaneous telangiectasia|Telangiectases|Spider veins	http://purl.obolibrary.org/obo/HP_0001009		
OBO:GOREL_0002004	biolink:NamedThing	results_in_fission_of		GOREL:0002004	hp.json		http://purl.obolibrary.org/obo/GOREL_0002004		
UBERON:0005310	biolink:AnatomicalEntity	pronephric nephron tubule	The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct[GO].	ZFA:0001558|TAO:0001558|XAO:0004105	hp.json	ciliated neck segment|pronephric tubule	http://purl.obolibrary.org/obo/UBERON_0005310		
HP:0001002	biolink:PhenotypicFeature	obsolete Decreased subcutaneous fat			hp.json		http://purl.obolibrary.org/obo/HP_0001002		
HP:0003665	biolink:PhenotypicFeature	Amyotrophy of the musculature of the pelvis	Muscular atrophy affecting the muscles of the pelvis.	UMLS:C4025581	hp.json		http://purl.obolibrary.org/obo/HP_0003665		
HP:0001003	biolink:PhenotypicFeature	Multiple lentigines	Presence of an unusually high number of lentigines (singular: lentigo), which are flat, tan to brown oval spots.	UMLS:C1328931|UMLS:C0036651|SNOMEDCT_US:72100002	hp.json	Liver spots	http://purl.obolibrary.org/obo/HP_0001003		hposlim_core
HP:0001000	biolink:PhenotypicFeature	Abnormality of skin pigmentation	An abnormality of the pigmentation of the skin.	UMLS:C1260926	hp.json	Abnormal skin color|Abnormality of pigmentation|Pigmentary skin changes|Abnormal skin colour|Abnormal pigmentation|Abnormal skin pigmentation|Pigmentary changes|Abnormality of skin pigmentation|Pigmentation anomaly	http://purl.obolibrary.org/obo/HP_0001000		hposlim_core
HP:0001001	biolink:PhenotypicFeature	Abnormality of subcutaneous fat tissue		UMLS:C4025813	hp.json	Abnormality of fatty tissue below the skin	http://purl.obolibrary.org/obo/HP_0001001		
HP:0001006	biolink:PhenotypicFeature	obsolete Hypotrichosis			hp.json		http://purl.obolibrary.org/obo/HP_0001006		
HP:0001007	biolink:PhenotypicFeature	Hirsutism	Abnormally increased hair growth referring to a male pattern of body hair (androgenic hair).	MSH:D006628|UMLS:C0019572|SNOMEDCT_US:399939002	hp.json	Excessive hairiness	http://purl.obolibrary.org/obo/HP_0001007		
HP:0001004	biolink:PhenotypicFeature	Lymphedema	Localized fluid retention and tissue swelling caused by a compromised lymphatic system.	SNOMEDCT_US:30213001|SNOMEDCT_US:234097001|MSH:D008209|UMLS:C0240278|UMLS:C0024236|UMLS:C1835229	hp.json	Onset of lymphedema around puberty|Lymphatic obstruction|Swelling caused by excess lymph fluid under skin|Lymphoedema	http://purl.obolibrary.org/obo/HP_0001004		
HP:0001005	biolink:PhenotypicFeature	Dermatological manifestations of systemic disorders		UMLS:C4025812	hp.json		http://purl.obolibrary.org/obo/HP_0001005		secondary_consequence
UBERON:0005317	biolink:AnatomicalEntity	pulmonary artery endothelium	An pulmonary artery endothelium is an epithelium that lines the pulmonary artery[GO].	BTO:0000137	hp.json	pulmonary artery endothelial tube	http://purl.obolibrary.org/obo/UBERON_0005317		human_reference_atlas
UBERON:0005316	biolink:AnatomicalEntity	endocardial endothelium	The endothelial lining of the endocardium.	FMA:83596	hp.json	endocardium endothelium|endothelium of endocardium	http://purl.obolibrary.org/obo/UBERON_0005316		
UBERON:0005311	biolink:AnatomicalEntity	mammary placode	The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper[GO].	EMAPA:35541	hp.json	mammary anlage	http://purl.obolibrary.org/obo/UBERON_0005311		
GO:0006518	biolink:BiologicalProcess	peptide metabolic process	The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.		hp.json	peptide metabolism	http://purl.obolibrary.org/obo/GO_0006518		goslim_pir
HP:0001019	biolink:PhenotypicFeature	Erythroderma	An inflammatory exfoliative dermatosis involving nearly all of the surface of the skin. Erythroderma develops suddenly. A patchy erythema may generalize and spread to affect most of the skin. Scaling may appear in 2-6 days and be accompanied by hot, red, dry skin, malaise, and fever.	SNOMEDCT_US:396350005|SNOMEDCT_US:400005007|SNOMEDCT_US:200948000|MSH:D003873|SNOMEDCT_US:396349005|SNOMEDCT_US:399992009|UMLS:C0011606	hp.json	Generalised erythrodermia|Generalized erythroderma|Exfoliative dermititis|Generalized erythrodermia|Generalised erythroderma|Red scaly skin caused by inflammatory skin disease	http://purl.obolibrary.org/obo/HP_0001019		
HP:0001013	biolink:PhenotypicFeature	Eruptive xanthomas	Eruptive xanthomas are yellow-orange-to-red-brown papules that are often surrounded by an erythematous halo. They appear in crops on the buttocks, extensor surfaces of the extremities, and flexural creases. Acutely, variable amounts of pruritus and pain occur.	SNOMEDCT_US:238952003|UMLS:C0221252	hp.json		http://purl.obolibrary.org/obo/HP_0001013		
HP:0003676	biolink:PhenotypicFeature	Progressive	Applies to a disease manifestation that increases in scope or severity over the course of time, i.e., that worsens with age.	SNOMEDCT_US:252157006|UMLS:C0205329|UMLS:C1864985|SNOMEDCT_US:255314001	hp.json	Worsens with time|Progressive disorder	http://purl.obolibrary.org/obo/HP_0003676		
HP:0001014	biolink:PhenotypicFeature	Angiokeratoma	A vascular lesion defined histologically as one or more dilated blood vessels lying directly subepidermal and showing an epidermal proliferative reaction. Clinically, angiokeratoma presents as a small, raised, dark-red spot.	MSH:D000794|UMLS:C0002985|SNOMEDCT_US:26810009	hp.json	Angiokeratomas	http://purl.obolibrary.org/obo/HP_0001014		
HP:0003674	biolink:PhenotypicFeature	Onset	The age group in which disease manifestations appear.	UMLS:C0206132|MSH:D017668	hp.json	Age symptoms begin|Age of onset	http://purl.obolibrary.org/obo/HP_0003674		
HP:0001011	biolink:PhenotypicFeature	obsolete Diaphoresis (with pheochromocytoma)			hp.json		http://purl.obolibrary.org/obo/HP_0001011		
HP:0001012	biolink:PhenotypicFeature	Multiple lipomas	The presence of multiple lipomas (a type of benign tissue made of fatty tissue).	UMLS:C0023798|SNOMEDCT_US:404062002|SNOMEDCT_US:46720004|MSH:D008067|UMLS:C0745730|SNOMEDCT_US:93163002|NCIT:C3192	hp.json	Lipomas|Lipomatosis|Multiple fatty lumps	http://purl.obolibrary.org/obo/HP_0001012		
HP:0001017	biolink:PhenotypicFeature	Anemic pallor	A type of pallor that is secondary to the presence of anemia.	UMLS:C4025811	hp.json	Anaemic pallor	http://purl.obolibrary.org/obo/HP_0001017		
HP:0001018	biolink:PhenotypicFeature	Abnormal palmar dermatoglyphics	An abnormality of the dermatoglyphs, i.e., an abnormality of the patterns of ridges of the skin of palm of hand.	UMLS:C4025810	hp.json		http://purl.obolibrary.org/obo/HP_0001018		
HP:0003679	biolink:PhenotypicFeature	Pace of progression		UMLS:C4025580	hp.json		http://purl.obolibrary.org/obo/HP_0003679		
HP:0003678	biolink:PhenotypicFeature	Rapidly progressive	Applies to a disease manifestation that quickly increases in scope or severity over the course of time.	UMLS:C1850776|UMLS:C1838681	hp.json	Rapidly progressive disorder|Rapid progression|Worsening quickly	http://purl.obolibrary.org/obo/HP_0003678		
HP:0001015	biolink:PhenotypicFeature	Prominent superficial veins	A condition in which superficial veins (i.e., veins just under the skin) are more conspicuous or noticable than normal.	UMLS:C1837785	hp.json	Prominent veins|Marked subcutaneous veins	http://purl.obolibrary.org/obo/HP_0001015		
HP:0003677	biolink:PhenotypicFeature	Slowly progressive	Applies to a disease manifestation that only slowly increases in scope or severity over the course of time.	UMLS:C1854494	hp.json	Signs and symptoms worsen slowly with time|Slow progression|Slow disease progression|Slowly progressive disorder	http://purl.obolibrary.org/obo/HP_0003677		
HP:0001010	biolink:PhenotypicFeature	Hypopigmentation of the skin	A reduction of skin color related to a decrease in melanin production and deposition.	SNOMEDCT_US:18655006|SNOMEDCT_US:89031001|MSH:D017496|UMLS:C0162835|SNOMEDCT_US:201284005|SNOMEDCT_US:23006000	hp.json	Hypopigmentation|Skin hypopigmentation|Patchy lightened skin|Hypopigmented skin	http://purl.obolibrary.org/obo/HP_0001010		
HP:0003649	biolink:PhenotypicFeature	Abnormality of glycoside metabolism	Abnormality of glycoside metabolism.	UMLS:C4025584	hp.json		http://purl.obolibrary.org/obo/HP_0003649		
HP:0003648	biolink:PhenotypicFeature	Lacticaciduria	An increased concentration of lactic acid in the urine.	UMLS:C4025585	hp.json	High urine lactic acid levels|Increased urine lactate	http://purl.obolibrary.org/obo/HP_0003648		
HP:0003643	biolink:PhenotypicFeature	Sulfite oxidase deficiency	Abnormally reduced sulfite oxidase level.	SNOMEDCT_US:367368009|MSH:C538141|UMLS:C0268624	hp.json		http://purl.obolibrary.org/obo/HP_0003643		
HP:0003642	biolink:PhenotypicFeature	Type I transferrin isoform profile	Abnormal transferrin isoform profile consistent with a type I congenital disorder of glycosylation. In the traditional nomenclature for congenital disorders of glycosylation, absence of entire glycans was designated type I, and loss of one or more monosaccharides as type II.	UMLS:C1837899	hp.json	Abnormal isoelectric focusing of serum transferrin, type I pattern|Type 1 transferrin isoform profile|Isoelectric focusing of serum transferrin consistent with CDG type I	http://purl.obolibrary.org/obo/HP_0003642		
HP:0003641	biolink:PhenotypicFeature	Hemoglobinuria	The presence of free hemoglobin in the urine.	MSH:D006456|SNOMEDCT_US:68600005|UMLS:C0019048	hp.json	Haemoglobin in urine|Hemoglobin in urine	http://purl.obolibrary.org/obo/HP_0003641		
HP:0003640	biolink:PhenotypicFeature	CNS foam cells	The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, in the central nervous system.	UMLS:C1843373	hp.json		http://purl.obolibrary.org/obo/HP_0003640		
HP:0003647	biolink:PhenotypicFeature	Electron transfer flavoprotein-ubiquinone oxidoreductase defect	A deficiency of the electron transfer flavoprotein-ubiquinone oxidoreductase.	UMLS:C4025586	hp.json		http://purl.obolibrary.org/obo/HP_0003647		
HP:0003646	biolink:PhenotypicFeature	Bicarbonaturia	Abnormally increased concentration of hydrogencarbonate in the urine.	UMLS:C1839865	hp.json	Increased urine bicarbonate concentration|Increased urine HCO3 concentration	http://purl.obolibrary.org/obo/HP_0003646		
HP:0003645	biolink:PhenotypicFeature	Prolonged partial thromboplastin time	Increased time to coagulation in the partial thromboplastin time (PTT) test, a measure of the intrinsic and common coagulation pathways. Phospholipid, and activator, and calcium are mixed into an anticoagulated plasma sample, and the time is measured until a thrombus forms.	UMLS:C0240671|SNOMEDCT_US:409675001	hp.json	Prolonged activated partial thromboplastin time|Abnormal partial thromboplastin time|Partial thromboplastin time prolonged|Prolonged PTT|Delayed thromboplastin generation	http://purl.obolibrary.org/obo/HP_0003645		
UBERON:8440004	biolink:AnatomicalEntity	laminar subdivision of the cortex	One or a subset of adjacent layers of the neocortex.		hp.json		http://purl.obolibrary.org/obo/UBERON_8440004		
HP:0003654	biolink:PhenotypicFeature	Reduced dihydropyrimidine dehydrogenase level	An abnormal reduction in dihydropyrimidine dehydrogenase (NADP+) level.	UMLS:C1959620|MSH:D054067|SNOMEDCT_US:77365006|UMLS:C4025582	hp.json	Dihydropyrimidine dehydrogenase deficiency	http://purl.obolibrary.org/obo/HP_0003654		
HP:0003653	biolink:PhenotypicFeature	Cellular metachromasia	Metachromasia (also known as metachromacy) is a characteristic color change which certain aniline dyes exhibit when bound to particular substances or when concentrated in solution. For example, the basic dye toluidine blue becomes distinctly pink when bound to cartilage matrix. In the sense used here, the metachromasia refers to a change in color not observed with normal tissues, anomalous staining with the cationic dyes toluidine blue O and Alcian blue resulting from excessive amounts of the polyanionic glycosaminoglycans.	UMLS:C4025583	hp.json		http://purl.obolibrary.org/obo/HP_0003653		
HP:0003652	biolink:PhenotypicFeature	Recurrent myoglobinuria	Recurring episodes of myoglobinuria, i.e., of the presence of myoglobin in the urine. This is usually a consequence of rhabdomyolysis, i.e., of the destruction of muscle tissue.	MSH:C564018|UMLS:C1838877	hp.json	Myoglobinuria, episodic|Myoglobinuria, recurrent	http://purl.obolibrary.org/obo/HP_0003652		
HP:0003651	biolink:PhenotypicFeature	Foam cells	The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance.	UMLS:C0016390|SNOMEDCT_US:16980002|MSH:D005487	hp.json	Lipid-laden histiocytes|Foamy macrophages|Presence of foam cells|Foamy histiocytes	http://purl.obolibrary.org/obo/HP_0003651		
HP:0003658	biolink:PhenotypicFeature	Hypomethioninemia	A decreased concentration of methionine in the blood.	UMLS:C1848555	hp.json	Decreased plasma methionine|Decreased serum methionine	http://purl.obolibrary.org/obo/HP_0003658		
HP:0003657	biolink:PhenotypicFeature	Granular osmiophilic deposits (GROD) in cells		UMLS:C1859833	hp.json		http://purl.obolibrary.org/obo/HP_0003657		
HP:0003656	biolink:PhenotypicFeature	Decreased beta-glucocerebrosidase level	Reduced level of the enzyme beta-glucosidase, an enzyme that catalyzes the hydrolysis of glucosylceramide into ceramide and glucose.	UMLS:C1842710	hp.json	Decreased lysosomal acid glucosylceramidase activity	http://purl.obolibrary.org/obo/HP_0003656		
HP:0003655	biolink:PhenotypicFeature	Reduced level of N-acetylglucosaminyltransferase II	An abnormality of glycoprotein metabolism related to a decreased level of alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity.	UMLS:C4021725	hp.json	Deficient N-acetylglucosaminyltransferase II	http://purl.obolibrary.org/obo/HP_0003655		
CHEBI:17196	biolink:ChemicalSubstance	L-asparagine	An optically active form of asparagine having L-configuration.	MetaCyc:ASN|Reaxys:1723527|Beilstein:1723527|HMDB:HMDB0000168|CAS:70-47-3|Gmelin:3334|PMID:16368161|PMID:22513289|CAS:70-47-3|PMID:21854356|PMID:21800258|PDBeChem:ASN|PMID:12142634|FooDB:FDB000787|ECMDB:ECMDB00168|DrugBank:DB00174|PMID:16190636|Drug_Central:4126|KNApSAcK:C00001341|PMID:17497286|Wikipedia:Asparagine|PMID:16668324|PMID:15907185|YMDB:YMDB00226|CAS:70-47-3|KEGG:C00152	hp.json	(S)-Asparagine|L-aspartic acid beta-amide|2-Aminosuccinamic acid|Asn|L-2-aminosuccinamic acid|ASPARAGINE|Aspartamic acid|L-asparagine|(2S)-2-amino-3-carbamoylpropanoic acid|(2S)-2,4-diamino-4-oxobutanoic acid|(S)-2-amino-3-carbamoylpropanoic acid|L-Asparagin|L-Asparagine|N|alpha-aminosuccinamic acid	http://purl.obolibrary.org/obo/CHEBI_17196		3_STAR
GO:0016070	biolink:BiologicalProcess	RNA metabolic process	The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.		hp.json	RNA metabolism	http://purl.obolibrary.org/obo/GO_0016070		goslim_agr|goslim_candida|goslim_pir|goslim_aspergillus|goslim_metagenomics
GO:0065002	biolink:BiologicalProcess	intracellular protein transmembrane transport	The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.		hp.json	intracellular protein transport across a membrane|intracellular membrane translocation of a protein|intracellular protein membrane transport	http://purl.obolibrary.org/obo/GO_0065002		
GO:0065003	biolink:BiologicalProcess	protein-containing complex assembly	The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.		hp.json	macromolecular complex assembly|cellular protein complex assembly|chaperone activity|cellular macromolecule complex assembly|cellular protein-containing complex assembly|protein complex formation|macromolecule complex assembly|protein complex assembly	http://purl.obolibrary.org/obo/GO_0065003		goslim_pir|goslim_pombe|goslim_drosophila|goslim_chembl|goslim_metagenomics|goslim_generic
GO:0065008	biolink:BiologicalProcess	regulation of biological quality	Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.		hp.json	regulation of biological attribute|regulation of biological characteristic	http://purl.obolibrary.org/obo/GO_0065008		goslim_pir
GO:0065009	biolink:BiologicalProcess	regulation of molecular function	Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.		hp.json	regulation of a molecular function	http://purl.obolibrary.org/obo/GO_0065009		gocheck_do_not_annotate|goslim_pir|goslim_plant
GO:0065007	biolink:BiologicalProcess	biological regulation	Any process that modulates a measurable attribute of any biological process, quality or function.		hp.json	regulation	http://purl.obolibrary.org/obo/GO_0065007		gocheck_do_not_annotate|goslim_pir
GO:0004095	biolink:MolecularActivity	carnitine O-palmitoyltransferase activity	Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.	Reactome:R-HSA-200410|RHEA:12661|Reactome:R-HSA-200406|MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN|EC:2.3.1.21	hp.json	CPTi|acylcarnitine transferase activity|carnitine palmitoyltransferase I|palmitoylcarnitine transferase activity|CPT I (outer membrane carnitine palmitoyl transferase)|CPT-B|carnitine palmitoyltransferase-A|CPT-A|palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity|CPTo|carnitine palmitoyltransferase II|CPT|carnitine palmitoyltransferase activity|L-carnitine palmitoyltransferase activity|outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity	http://purl.obolibrary.org/obo/GO_0004095		
GO:0016050	biolink:BiologicalProcess	vesicle organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.		hp.json	vesicle organisation|vesicle organization and biogenesis	http://purl.obolibrary.org/obo/GO_0016050		goslim_yeast|goslim_pir
PATO:0001236	biolink:NamedThing	process quality	A quality which inheres in an process.		hp.json	quality of a process|quality of process|relational quality of occurrent|quality of occurrent	http://purl.obolibrary.org/obo/PATO_0001236		
PATO:0001230	biolink:NamedThing	strength	A quality inhering in a bearer by virtue of the bearer's power or force.		hp.json		http://purl.obolibrary.org/obo/PATO_0001230		attribute_slim|scalar_slim
GO:0016049	biolink:BiologicalProcess	cell growth	The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.		hp.json	non-developmental growth of a unicellular organism|metabolism resulting in cell growth|non-developmental cell growth|growth of cell|metabolic process resulting in cell growth|cellular growth|cell expansion	http://purl.obolibrary.org/obo/GO_0016049		gocheck_do_not_annotate|goslim_pir|goslim_plant|goslim_drosophila
GO:0016043	biolink:BiologicalProcess	cellular component organization	A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.		hp.json	cell organization and biogenesis|cellular component organisation in other organism|cellular component organisation at cellular level|cellular component organization in other organism|cell organisation|cellular component organization at cellular level	http://purl.obolibrary.org/obo/GO_0016043		goslim_mouse|goslim_agr|goslim_pir|goslim_plant
GO:0065010	biolink:CellularComponent	extracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.		hp.json	extracellular membrane-enclosed organelle	http://purl.obolibrary.org/obo/GO_0065010		
PATO:0001241	biolink:NamedThing	physical object quality	A quality which inheres in a continuant.	snap:Quality	hp.json	multiply inhering quality of a physical entity|monadic quality of an object|quality of continuant|quality of a continuant|monadic quality of continuant|quality of a single physical entity|quality of an object|monadic quality of a continuant	http://purl.obolibrary.org/obo/PATO_0001241		
GO:0016057	biolink:BiologicalProcess	regulation of membrane potential in photoreceptor cell	Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.		hp.json	changes in polarization state of photoreceptor cell membrane	http://purl.obolibrary.org/obo/GO_0016057		
GO:0016051	biolink:BiologicalProcess	carbohydrate biosynthetic process	The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.		hp.json	carbohydrate formation|anabolic carbohydrate metabolic process|anabolic carbohydrate metabolism|carbohydrate anabolism|carbohydrate biosynthesis|carbohydrate synthesis	http://purl.obolibrary.org/obo/GO_0016051		
GO:0016052	biolink:BiologicalProcess	carbohydrate catabolic process	The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.		hp.json	single-organism carbohydrate catabolic process|carbohydrate breakdown|carbohydrate catabolism|multicellular organismal carbohydrate catabolic process|carbohydrate degradation|catabolic carbohydrate metabolic process|catabolic carbohydrate metabolism	http://purl.obolibrary.org/obo/GO_0016052		
GO:0016053	biolink:BiologicalProcess	organic acid biosynthetic process	The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.		hp.json	organic acid formation|organic acid anabolism|organic acid biosynthesis|organic acid synthesis	http://purl.obolibrary.org/obo/GO_0016053		
GO:0031667	biolink:BiologicalProcess	response to nutrient levels	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.		hp.json		http://purl.obolibrary.org/obo/GO_0031667		
HP:0003826	biolink:PhenotypicFeature	Stillbirth	Death of the fetus in utero after at least 22 weeks of gestation.	SNOMEDCT_US:237364002|MSH:D005313|UMLS:C0595939|SNOMEDCT_US:276507005|MSH:D050497|UMLS:C0015927	hp.json	Foetal death|Stillbirth|Late fetal death|Fetal demise|Stillborn|Fetal death	http://purl.obolibrary.org/obo/HP_0003826		
HP:0003829	biolink:PhenotypicFeature	Typified by incomplete penetrance	Description of conditions in which only a limited proportion of individuals with a given genotype exhibit the disease regardless of age.	UMLS:C1836598	hp.json	Incomplete penetrance|Reduced penetrance	http://purl.obolibrary.org/obo/HP_0003829		
HP:0003828	biolink:PhenotypicFeature	Variable expressivity	A variable severity of phenotypic features.	UMLS:C1861403|UMLS:C1866862	hp.json	Variable severity|Highly variable severity	http://purl.obolibrary.org/obo/HP_0003828		
GO:0016020	biolink:CellularComponent	membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.	Wikipedia:Biological_membrane	hp.json	membrane region|region of membrane|whole membrane	http://purl.obolibrary.org/obo/GO_0016020		goslim_pir|goslim_plant|goslim_flybase_ribbon|goslim_aspergillus|goslim_chembl|goslim_metagenomics|goslim_yeast|goslim_candida
HP:0003837	biolink:PhenotypicFeature	Soft-tissue ossification around the shoulders	Formation of calcified tissue in the soft tissues surrounding the shoulder.	UMLS:C4025561	hp.json	Calcification of the soft-tissue around the shoulders	http://purl.obolibrary.org/obo/HP_0003837		
HP:0003836	biolink:PhenotypicFeature	Stippled calcification of the shoulder		UMLS:C4025562	hp.json		http://purl.obolibrary.org/obo/HP_0003836		
HP:0003835	biolink:PhenotypicFeature	Shoulder subluxation	A partial dislocation of the shoulder joint.	UMLS:C0434744|SNOMEDCT_US:263051004	hp.json	Partial shoulder dislocation	http://purl.obolibrary.org/obo/HP_0003835		
HP:0003839	biolink:PhenotypicFeature	Abnormality of upper limb epiphysis morphology		UMLS:C4021722	hp.json	Abnormal shape of end part of upper limb long bones|Abnormality involving the epiphyses of the upper limbs|Epihyseal plate abnormality of the upper limbs	http://purl.obolibrary.org/obo/HP_0003839		
RO:0001025	biolink:Protein	located_in	a relation between two independent continuants, the target and the location, in which the target is entirely within the location	RO:0001025	hp.json		http://purl.obolibrary.org/obo/RO_0001025		http://purl.obolibrary.org/obo/valid_for_go_gp2term
HP:0003834	biolink:PhenotypicFeature	Shoulder dislocation	A displacement or misalignment of the humerus with respect to the other bones of the should joint. Note that a subluxation is a partial dislocation.	MSH:D012783|SNOMEDCT_US:125615005|UMLS:C0037005|SNOMEDCT_US:417076003	hp.json	Shoulder dislocation	http://purl.obolibrary.org/obo/HP_0003834		
HP:0003833	biolink:PhenotypicFeature	Laterally deficient tibial plateaux		UMLS:C4025563	hp.json		http://purl.obolibrary.org/obo/HP_0003833		
HP:0003832	biolink:PhenotypicFeature	Abnormality of the tibial plateaux		UMLS:C4025564	hp.json		http://purl.obolibrary.org/obo/HP_0003832		
HP:0003831	biolink:PhenotypicFeature	Typified by age-related penetrance	Description of conditions in which age of onset is typically later in life and in which penetrance is dependent on the age of the subject.	UMLS:C1835978	hp.json	Age dependent penetrance|Age-dependent penetrance	http://purl.obolibrary.org/obo/HP_0003831		
HP:0400008	biolink:PhenotypicFeature	Menometrorrhagia	Prolonged/excessive menses and bleeding at irregular intervals.	SNOMEDCT_US:314631008|SNOMEDCT_US:351814001|UMLS:C0232943	hp.json		http://purl.obolibrary.org/obo/HP_0400008		
HP:0400007	biolink:PhenotypicFeature	Polymenorrhea	Frequent menses; menstrual cycles lasting less than 21 days.	MSH:D008599|UMLS:C0032519|SNOMEDCT_US:52754008	hp.json		http://purl.obolibrary.org/obo/HP_0400007		
GO:0031645	biolink:BiologicalProcess	negative regulation of nervous system process	Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.		hp.json	negative regulation of neurological process|negative regulation of neurophysiological process|negative regulation of neurological system process|downregulation of neurological process|down regulation of neurological process|inhibition of neurological process|down-regulation of neurological process	http://purl.obolibrary.org/obo/GO_0031645		
HP:0400004	biolink:PhenotypicFeature	Long ear	Median longitudinal ear length greater than two SD above the mean determined by the maximal distance from the superior aspect to the inferior aspect of the external ear.	UMLS:C1848657	hp.json	Long ear|Long ears	http://purl.obolibrary.org/obo/HP_0400004		
GO:0031646	biolink:BiologicalProcess	positive regulation of nervous system process	Any process that activates or increases the frequency, rate or extent of a neurophysiological process.		hp.json	positive regulation of neurological system process|up regulation of neurological process|stimulation of neurological process|up-regulation of neurological process|activation of neurological process|positive regulation of neurological process|positive regulation of neurophysiological process|upregulation of neurological process	http://purl.obolibrary.org/obo/GO_0031646		
HP:0400003	biolink:PhenotypicFeature	Focal absence of the external ear	Absence of a localized portion of the ear that cannot be described by a more precise term (e.g., absent ear lobe).	UMLS:C4021874	hp.json		http://purl.obolibrary.org/obo/HP_0400003		
GO:0031643	biolink:BiologicalProcess	positive regulation of myelination	Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.		hp.json	up regulation of myelination|activation of myelination|stimulation of myelination|upregulation of myelination|up-regulation of myelination	http://purl.obolibrary.org/obo/GO_0031643		
GO:0006687	biolink:BiologicalProcess	glycosphingolipid metabolic process	The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.		hp.json	glycosphingolipid metabolism	http://purl.obolibrary.org/obo/GO_0006687		
CHEBI:42090	biolink:ChemicalSubstance	L-threitol	The L-enantiomer of threitol.	PDBeChem:DTL|DrugBank:DB03278|Beilstein:4652748|Beilstein:1719754|Gmelin:1971390|PMID:7925706|Reaxys:1719754|PMID:16901854|PMID:15639248|Beilstein:5725953|PMID:16671745	hp.json	L-threo-tetritol|D-TREITOL|L-threitol|(2S,3S)-butane-1,2,3,4-tetrol	http://purl.obolibrary.org/obo/CHEBI_42090		3_STAR
HP:0400005	biolink:PhenotypicFeature	Short ear	Median longitudinal ear length less than two SD above the mean determined by the maximal distance from the superior aspect to the inferior aspect of the external ear.	UMLS:C3551041	hp.json	Short ear|Short ears	http://purl.obolibrary.org/obo/HP_0400005		
GO:0031644	biolink:BiologicalProcess	regulation of nervous system process	Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.		hp.json	regulation of neurological system process|regulation of neurological process|regulation of neurophysiological process	http://purl.obolibrary.org/obo/GO_0031644		
HP:0400000	biolink:PhenotypicFeature	Tall chin	Increased vertical distance from the vermillion border of the lower lip to the inferior-most point of the chin.	SNOMEDCT_US:471397004|UMLS:C3532221|UMLS:C4021875	hp.json	Vertical excess of chin|Long chin|Vertical hyperplasia of chin|Tall chin|Increased height of menton region|Increased height of chin|Long lower third of face	http://purl.obolibrary.org/obo/HP_0400000		
HP:0003805	biolink:PhenotypicFeature	Rimmed vacuoles	Presence of abnormal vacuoles (membrane-bound organelles) in the sarcolemma. On histological staining with hematoxylin and eosin, rimmed vacuoles are popcorn-like clear vacuoles with a densely blue rim. The vacuoles are often associated with cytoplasmic and occasionally intranuclear eosinophilic inclusions.	UMLS:C1853932	hp.json	Rimmed vacuoles on biopsy	http://purl.obolibrary.org/obo/HP_0003805		
HP:0003803	biolink:PhenotypicFeature	Type 1 muscle fiber predominance	An abnormal predominance of type I muscle fibers (in general, this feature can only be observed on muscle biopsy).	UMLS:C1854387	hp.json	Type I muscle fibre predominance|Type 1 muscle fibre predominance|Type I muscle fiber predominance	http://purl.obolibrary.org/obo/HP_0003803		
HP:0400002	biolink:PhenotypicFeature	Extra concha fold	Folds or ridges within the concha that are distinct from the crus helix.	UMLS:C4020915	hp.json	Concha, Extra Fold	http://purl.obolibrary.org/obo/HP_0400002		
HP:0400001	biolink:PhenotypicFeature	Chin with vertical crease	Vertical crease fold situated below the vermilion border of the lower lip and above the fatty pad of the chin with the face at rest.	UMLS:C4020916	hp.json	Vertical chin skin cleft|Chin with vertical crease|Chin with vertical groove|Chin, vertical crease|Cleft chin|Chin with vertical sulcus|Chin with vertical furrow|Vertical menton crease	http://purl.obolibrary.org/obo/HP_0400001		
HP:0003809	biolink:PhenotypicFeature	Reduced intrathoracic adipose tissue	An abnormally reduced amount of adipose tissue in the thoracic cavity.	UMLS:C1837797	hp.json		http://purl.obolibrary.org/obo/HP_0003809		
HP:0003808	biolink:PhenotypicFeature	Abnormal muscle tone		UMLS:C0852413	hp.json	Abnormal muscle tone	http://purl.obolibrary.org/obo/HP_0003808		
RO:0001018	biolink:NamedThing	contained in			hp.json		http://purl.obolibrary.org/obo/RO_0001018		ro-eco
RO:0001019	biolink:NamedThing	contains		RO:0001019	hp.json		http://purl.obolibrary.org/obo/RO_0001019		ro-eco
RO:0001015	biolink:NamedThing	location of	a relation between two independent continuants, the location and the target, in which the target is entirely within the location	RO:0001015	hp.json		http://purl.obolibrary.org/obo/RO_0001015		
HP:0003800	biolink:PhenotypicFeature	Muscle abnormality related to mitochondrial dysfunction		UMLS:C4025566	hp.json		http://purl.obolibrary.org/obo/HP_0003800		
GO:0031641	biolink:BiologicalProcess	regulation of myelination	Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.		hp.json		http://purl.obolibrary.org/obo/GO_0031641		
GO:0031642	biolink:BiologicalProcess	negative regulation of myelination	Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.		hp.json	down-regulation of myelination|down regulation of myelination|inhibition of myelination|downregulation of myelination	http://purl.obolibrary.org/obo/GO_0031642		
GO:0006699	biolink:NamedThing	bile acid biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0006699		
GO:0004035	biolink:MolecularActivity	alkaline phosphatase activity	Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.	MetaCyc:ALKAPHOSPHA-RXN|Reactome:R-HSA-8878787|EC:3.1.3.1	hp.json	glycerophosphatase activity|orthophosphoric-monoester phosphohydrolase (alkaline optimum)|alkaline phosphomonoesterase activity|phosphomonoesterase activity|alkaline phosphohydrolase activity|alkaline phenyl phosphatase activity|phosphate-monoester phosphohydrolase (alkaline optimum)	http://purl.obolibrary.org/obo/GO_0004035		
GO:0006694	biolink:BiologicalProcess	steroid biosynthetic process	The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.	Wikipedia:Steroid_metabolisms#Steroid_biosynthesis	hp.json	steroidogenesis|steroid anabolism|steroid biosynthesis|steroid synthesis|steroid formation	http://purl.obolibrary.org/obo/GO_0006694		
GO:0006692	biolink:BiologicalProcess	prostanoid metabolic process	The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure.		hp.json	prostanoid metabolism	http://purl.obolibrary.org/obo/GO_0006692		
GO:0006693	biolink:BiologicalProcess	prostaglandin metabolic process	The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.		hp.json	prostaglandin metabolism	http://purl.obolibrary.org/obo/GO_0006693		
HP:0003819	biolink:PhenotypicFeature	Death in childhood	Death in during childhood, defined here as between the ages of 2 and 10 years.	UMLS:C1843392	hp.json	Death in childhood	http://purl.obolibrary.org/obo/HP_0003819		
GO:0006690	biolink:BiologicalProcess	icosanoid metabolic process	The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.		hp.json	eicosanoid metabolism|eicosanoid metabolic process|icosanoid metabolism	http://purl.obolibrary.org/obo/GO_0006690		
HP:0003812	biolink:PhenotypicFeature	Phenotypic variability	A variability of phenotypic features.	UMLS:C1839039|UMLS:C1850667|UMLS:C1837514|UMLS:C1866210	hp.json	Variable phenotypic severity|Highly variable phenotype and severity|Clinical heterogeneity|Highly variable clinical phenotype|Highly variable phenotype, even within families|Highly variable phenotype|Variable phenotype	http://purl.obolibrary.org/obo/HP_0003812		
HP:0003811	biolink:PhenotypicFeature	Neonatal death	Death within the first 28 days of life.	SNOMEDCT_US:276506001|MSH:D066087|UMLS:C0410916	hp.json	Neonatal lethal	http://purl.obolibrary.org/obo/HP_0003811		
PATO:0001201	biolink:NamedThing	Y-shaped	A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter Y.		hp.json		http://purl.obolibrary.org/obo/PATO_0001201		value_slim|cell_quality
HP:0003810	biolink:PhenotypicFeature	Late-onset distal muscle weakness		UMLS:C4025565	hp.json		http://purl.obolibrary.org/obo/HP_0003810		
GO:0043616	biolink:BiologicalProcess	keratinocyte proliferation	The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.		hp.json		http://purl.obolibrary.org/obo/GO_0043616		
CHEBI:91007	biolink:ChemicalSubstance	aromatic carboxylate	A carboxylic acic anion obtained by deprotonation of the carboxy group of any aromatic carboxylic acid. Major species at pH 7.3.		hp.json	an aromatic carboxylate	http://purl.obolibrary.org/obo/CHEBI_91007		3_STAR
CL:0019018	biolink:Cell	blood vessel smooth muscle cell	A smooth muscle cell that is part of any blood vessel.		hp.json	smooth muscle cell of blood vessel	http://purl.obolibrary.org/obo/CL_0019018		
HP:0025192	biolink:PhenotypicFeature	Subtentorial periventricular white matter hyperdensity	Areas of brighter than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the fourth cerebral ventricle (which is located beneath the tentorium of the cerebellum).		hp.json		http://purl.obolibrary.org/obo/HP_0025192		
HP:0025193	biolink:PhenotypicFeature	Posterolateral diaphragmatic hernia	A posterolateral defect in the diaphragm, commonly referred to as a Bochdalek hernia, which is often accompanied by herniation of the stomach, intestines, liver, and/or spleen into the chest cavity.		hp.json	Bochdalek hernia	http://purl.obolibrary.org/obo/HP_0025193		
CHEBI:20702	biolink:ChemicalSubstance	2-aminopurines	Any aminopurine having the amino substituent at the 2-position.		hp.json	2-aminopurines	http://purl.obolibrary.org/obo/CHEBI_20702		3_STAR
HP:0025194	biolink:PhenotypicFeature	Morgagni diaphragmatic hernia	An anterior retrosternal or parasternal hernia that can result in the herniation of liver or intestines into the chest cavity.		hp.json	Morgagni hernia	http://purl.obolibrary.org/obo/HP_0025194		
HP:0025195	biolink:PhenotypicFeature	Central diaphragmatic hernia	A congenital diaphragm defect involving the central tendinous (e.g., amuscular) portion of the diaphragm, whereby the entire rim of diaphragmatic musculature is present.		hp.json	Central hernia	http://purl.obolibrary.org/obo/HP_0025195		
HP:0025196	biolink:PhenotypicFeature	Increased total iron binding capacity	An elevation in the total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. A high TIBC corresponds to a high transferrin concentration. The latent (or free) iron binding capacity is the difference between the TIBC and the measured serum iron, corresponding to the transferrin not bound to iron, i.e., free iron binding capacity.		hp.json		http://purl.obolibrary.org/obo/HP_0025196		
HP:0025197	biolink:PhenotypicFeature	Inclusion body fibromatosis	A benign tumor made up of mostly myofibroblasts that appears almost exclusively on the digits of the hands and feet, rarely involving the thumb or big toe. The lesion displays a proliferation of bland intradermal spindle cells arranged in whorls, fascicles, or a storiform pattern in a collagenous background of varying degrees. Also usually present are perpendicular tumor cell fascicles that extend to the epidermis. The small intracytoplasmic inclusions are said to appear similar to red blood cells. The inclusion bodies have been shown to be made up of densely packed vimentin and actin filaments. The tumor often causes a dome-shaped elevation of the overlying structures, forming a protuberant or polypoid nodule. The overlying epidermis can display a host of changes, including acanthosis, hyperkeratosis, parakeratosis, rete ridge flattening, entrapment of adnexal structures, and, rarely, ulceration.		hp.json	Infantile digital fibromatosis|Digital fibrous tumor of Reye|Digital fibrous tumour of Reye|Infantile digital fibroma	http://purl.obolibrary.org/obo/HP_0025197		
HP:0025198	biolink:PhenotypicFeature	Inflammatory cap polyp	A non-malignant sessile or pedunculated polyp in the colon and rectum that displays a cap of inflammatory granulation tissue with fibrinopurulent exudate that covers the polyp.		hp.json		http://purl.obolibrary.org/obo/HP_0025198		
CHEBI:20706	biolink:ChemicalSubstance	6-aminopurines	Any compound having 6-aminopurine (adenine) as part of its structure.	PMID:7342604|PMID:1646334|PMID:18524423	hp.json	6-aminopurines	http://purl.obolibrary.org/obo/CHEBI_20706		3_STAR
CL:0007011	biolink:Cell	enteric neuron	Neuron that is part of the enteric nervous system.		hp.json		http://purl.obolibrary.org/obo/CL_0007011		
HP:0025190	biolink:PhenotypicFeature	Bilateral tonic-clonic seizure with generalized onset	A bilateral tonic-clonic seizure with generalized onset is a type of bilateral tonic-clonic seizure characterised by generalized onset; these seizures rapidly engage networks in both hemispheres at the start of the seizure.		hp.json	Generalised-onset tonic-clonic seizure|Primary generalised tonic-clonic seizures|Generalized tonic-clonic seizure without focal onset|Generalised tonic-clonic seizures without focal onset|Primary generalized tonic-clonic seizure|Primarily generalised tonic-clonic seizures|Generalized tonic-clonic seizure without partial onset|Generalized-onset tonic-clonic seizure|Primary generalized tonic-clonic seizures|Generalised tonic-clonic seizure without focal onset|Generalized tonic-clonic seizures without focal onset|Primary generalised tonic-clonic seizure|Bilateral tonic-clonic seizure with generalised onset|Primarily generalized tonic-clonic seizures|Generalised tonic-clonic seizure without partial onset	http://purl.obolibrary.org/obo/HP_0025190		
HP:0025191	biolink:PhenotypicFeature	obsolete Segmental myoclonic seizures			hp.json		http://purl.obolibrary.org/obo/HP_0025191		
GO:0043648	biolink:BiologicalProcess	dicarboxylic acid metabolic process	The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).		hp.json	dicarboxylate metabolism|dicarboxylate metabolic process|dicarboxylic acid metabolism	http://purl.obolibrary.org/obo/GO_0043648		
HP:0025181	biolink:PhenotypicFeature	Abdominal aseptic abscess	An abscess-like lesion located within the abdomen. The lesions are localized in the spleen, liver, abdominal lymph nodes. The lesions represent visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids, but relapses occur frequently.		hp.json		http://purl.obolibrary.org/obo/HP_0025181		
HP:0025182	biolink:PhenotypicFeature	Localized area of pendulous skin	A confined region of lax skin that hangs below the level of the surrounding skin. Histopatholigically, there is a loss of elastic fibers in the dermis of the affected region.		hp.json	Localised area of pendulous skin	http://purl.obolibrary.org/obo/HP_0025182		
HP:0025186	biolink:PhenotypicFeature	Marcus Gunn jaw winking synkinesis	Unilateral ptosis with associated upper eyelid contraction and contraction of either the external or the internal pterygoid muscle. It is thought to occur because of congenital miswiring of a branch of the fifth cranial nerve into the branch of the third cranial nerve supplying the levator muscle. In Marcus Gunn jaw winking synkinesis, elevation and even retraction of the affected eyelid is triggered by chewing, suction, lateral mandible movement, smiling, sternocleidomastoid contraction, protruding tongue, Valsalva manoeuvre and even by breathing.		hp.json	Marcus Gunn jaw-winking syndrome|Pterygoid-levator synkinesis|Trigemino-oculomotor synkinesis	http://purl.obolibrary.org/obo/HP_0025186		
HP:0025188	biolink:PhenotypicFeature	Retinal vasculitis	Inflammation of retinal blood vessels as manifested by perivascular sheathing or cuffing, vascular leakage and/or occlusion.		hp.json		http://purl.obolibrary.org/obo/HP_0025188		
GO:0043650	biolink:BiologicalProcess	dicarboxylic acid biosynthetic process	The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.		hp.json	dicarboxylic acid anabolism|dicarboxylate biosynthesis|dicarboxylate biosynthetic process|dicarboxylic acid biosynthesis|dicarboxylic acid synthesis|dicarboxylic acid formation	http://purl.obolibrary.org/obo/GO_0043650		
OBO:uberon/core#in_central_side_of	biolink:NamedThing	in_central_side_of	X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides.		hp.json		http://purl.obolibrary.org/obo/uberon/core#in_central_side_of		
CL:0007009	biolink:Cell	prechondroblast	Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells.		hp.json		http://purl.obolibrary.org/obo/CL_0007009		
CL:0007001	biolink:Cell	skeletogenic cell	Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).		hp.json	scleroblast	http://purl.obolibrary.org/obo/CL_0007001		
CL:0007002	biolink:Cell	precementoblast	Skeletogenic cell that has the potential to develop into a cementoblast.		hp.json		http://purl.obolibrary.org/obo/CL_0007002		
CL:0007003	biolink:Cell	preodontoblast	Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell.		hp.json		http://purl.obolibrary.org/obo/CL_0007003		
CL:0007004	biolink:Cell	premigratory neural crest cell	Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.		hp.json		http://purl.obolibrary.org/obo/CL_0007004		
CL:0007000	biolink:Cell	preameloblast	Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins.		hp.json		http://purl.obolibrary.org/obo/CL_0007000		
PR:000017364	biolink:Protein	von Willebrand factor	A protein that is a translation product of the human VWF gene or a 1:1 ortholog thereof.		hp.json	F8VWF|VWF|vWF	http://purl.obolibrary.org/obo/PR_000017364		
CHEBI:29016	biolink:ChemicalSubstance	arginine	An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	CAS:7200-25-1|Beilstein:1725411|Reaxys:1725411|KEGG:C02385|Wikipedia:L-Arginine|PMID:10848923	hp.json	2-amino-5-(carbamimidamido)pentanoic acid|arginine|2-amino-5-guanidinopentanoic acid|Arginine|Arginin|Harg|2-Amino-5-guanidinovaleric acid	http://purl.obolibrary.org/obo/CHEBI_29016		3_STAR
UBERON:0005475	biolink:AnatomicalEntity	sigmoid sinus	A portion of the lateral venous sinus, bulging prominently into the mastoid cavity, that serves as a principal conduit by which blood leaves the cranium[EPIC]. The sigmoid is drained by the internal jugular vein.	EMAPA:19060|ncithesaurus:Sigmoid_Sinus|EHDAA:9880|VHOG:0001337|FMA:50782|EHDAA2:0001838	hp.json	sulcus sigmoideus	http://purl.obolibrary.org/obo/UBERON_0005475		human_reference_atlas
HP:0025134	biolink:PhenotypicFeature	Increased serum estradiol	An elevation above normal limits of the concentration of estradiol in the circulation.		hp.json	Increased estradiol level|Increased serum oestradiol	http://purl.obolibrary.org/obo/HP_0025134		
HP:0001167	biolink:PhenotypicFeature	Abnormality of finger	An anomaly of a finger.	UMLS:C2674737	hp.json	Abnormalities of the fingers|Abnormality of finger	http://purl.obolibrary.org/obo/HP_0001167		
CHEBI:32660	biolink:ChemicalSubstance	asparaginate	An alpha-amino-acid anion that is the conjugate base of asparagine, arising from deprotonation of the carboxy group.	Gmelin:327370	hp.json	2,4-diamino-4-oxobutanoate|asparaginate|asparagine anion|asp(-)	http://purl.obolibrary.org/obo/CHEBI_32660		3_STAR
HP:0025135	biolink:PhenotypicFeature	Abnormal serum estriol	A deviation from normal concentration of estriol in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025135		
CHEBI:32661	biolink:ChemicalSubstance	asparaginium			hp.json	3-amino-1-carboxy-3-oxopropan-1-aminium|H2asp(+)|asparagine cation|asparaginium	http://purl.obolibrary.org/obo/CHEBI_32661		3_STAR
UBERON:0005473	biolink:AnatomicalEntity	sacral region	A subdivision of an organism along the anterior-posterior axis in the pelvic region immediately posterior to the lumbar region and anterior to the caudal region. Sometimes an intermediate region is defined between the sacral and caudal.	FMA:24228	hp.json	croup|posterior part of pelvis|rump|hindquarter|pelvic back|regio sacralis|sacral part of pelvis|back of pelvis	http://purl.obolibrary.org/obo/UBERON_0005473		
HP:0025136	biolink:PhenotypicFeature	Increased serum estriol	An elevation above normal limits of estriol concentration in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025136		
UBERON:0005472	biolink:AnatomicalEntity	right vitelline vein	A vitelline vein that is in the right side of a multicellular organism.	EMAPA:16699|FMA:70306|EHDAA2:0001766|EMAPA:16381|SCTID:361445007	hp.json		http://purl.obolibrary.org/obo/UBERON_0005472		
HP:0025137	biolink:PhenotypicFeature	Decreased serum estriol	A reduction below normal limits of estriol in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025137		
HP:0001166	biolink:PhenotypicFeature	Arachnodactyly	Abnormally long and slender fingers ("spider fingers").	SNOMEDCT_US:62250003|MSH:D054119|UMLS:C0003706	hp.json	Long slender fingers|Long, slender fingers|Spider fingers	http://purl.obolibrary.org/obo/HP_0001166		
HP:0025138	biolink:PhenotypicFeature	Abnormal serum estrone	A deviation from the normal concentration of circulating estrone.		hp.json		http://purl.obolibrary.org/obo/HP_0025138		
UBERON:0005470	biolink:AnatomicalEntity	right umbilical artery		FMA:18821|EHDAA2:0001760|VHOG:0000523|EMAPA:16545	hp.json	embryonic right umbilical artery	http://purl.obolibrary.org/obo/UBERON_0005470		
HP:0025139	biolink:PhenotypicFeature	Increased serum estrone	An elevation above normal limits of the concentration of estrone in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025139		
HP:0001169	biolink:PhenotypicFeature	Broad palm	For children from birth to 4 years of age the palm width is more than 2 SD above the mean; for children from 4 to 16 years of age the palm width is above the 95th centile; or, the width of the palm appears disproportionately wide for the length.	UMLS:C0264142|SNOMEDCT_US:48251003	hp.json	Broad hands|Broad palm|Wide palm|Broad hand	http://purl.obolibrary.org/obo/HP_0001169		
CHEBI:17026	biolink:ChemicalSubstance	progesterone	A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.	CAS:57-83-0|Drug_Central:2279|Wikipedia:Progesterone|KEGG:C00410|Beilstein:1915950|MetaCyc:PROGESTERONE|Reaxys:1915950|KEGG:D00066|PMID:9506942|PDBeChem:STR|HMDB:HMDB0001830|CAS:57-83-0|PMID:10438974|DrugBank:DB00396|CAS:57-83-0|Gmelin:708590	hp.json	Delta(4)-pregnene-3,20-dione|(S)-Pregn-4-en-3,20-dione|pregn-4-ene-3,20-dione|17alpha-progesterone|Akrolutin|Progesterone|Gelbkoerperhormon|Progesteron|Crinone|(S)-4-Pregnene-3,20-dione|PROGESTERONE|4-Pregnene-3,20-dione|luteohormone|corpus luteum hormone|(S)-Progesterone|progesterone|Agolutin	http://purl.obolibrary.org/obo/CHEBI_17026		3_STAR
HP:0025130	biolink:PhenotypicFeature	Decreased small intestinal mucosa lactase level	Lactase is produced in the small intestine in humans, Lactase is a member of the beta-galactosidase family of enzymes, and hydrolyzes D-lactose to form D-galactose and D-glucose, which can be absorbed by the small intestine. There are many ways of assessing lactase activity. In one test, an endoscopic biopsy from the postbulbar duodenum is incubated with lactose on a test plate, and a color reaction develops within 20 min as a result of hydrolyzed lactose (a positive result) in patients with normolactasia, whereas no reaction (a negative result) develops in patients with severe hypolactasia. Other, less direct, tests include the hydrogen breath test, and blood tests following lactose challenges.		hp.json	Lactase deficiency	http://purl.obolibrary.org/obo/HP_0025130		
HP:0001163	biolink:PhenotypicFeature	Abnormality of the metacarpal bones			hp.json		http://purl.obolibrary.org/obo/HP_0001163		
UBERON:0005478	biolink:AnatomicalEntity	sulcus limitans of neural tube	A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD].	BAMS:slim|BAMS:slm|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=629	hp.json	neural tube lateral wall sulcus limitans|sulcus limitans	http://purl.obolibrary.org/obo/UBERON_0005478		
HP:0025131	biolink:PhenotypicFeature	Finger swelling	Enlargement of the soft tissues of one or more fingers.		hp.json	Swollen finger|Swelling of fingers|Swollen fingers	http://purl.obolibrary.org/obo/HP_0025131		
HP:0025132	biolink:PhenotypicFeature	Abnormal circulating estrogen level	A deviation from normal concentration of the hormone estrogen in the blood circulation.		hp.json	Abnormal circulating oestrogen level|Abnormal estrogen level|Abnormal oestrogen level	http://purl.obolibrary.org/obo/HP_0025132		
HP:0001161	biolink:PhenotypicFeature	Hand polydactyly	A kind of polydactyly characterized by the presence of a supernumerary finger or fingers.	MEDDRA:10036064|SNOMEDCT_US:81793007|UMLS:C0158733	hp.json	Finger polydactyly|Polydactyly of the hand|Supernumerary finger|Extra finger	http://purl.obolibrary.org/obo/HP_0001161		hposlim_core
HP:0001162	biolink:PhenotypicFeature	Postaxial hand polydactyly	Supernumerary digits located at the ulnar side of the hand (that is, on the side with the fifth finger).	SNOMEDCT_US:205131007|UMLS:C0431904	hp.json	Postaxial polydactyly of fingers|Polydactyly affecting the 5th finger|Postaxial polydactyly of hands|Postaxial polydactyly of hand|Extra pinkie finger|Extra pinky finger|Extra little finger	http://purl.obolibrary.org/obo/HP_0001162		hposlim_core
HP:0025133	biolink:PhenotypicFeature	Abnormal serum estradiol	A deviation from normal concentrations of estradiol in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025133		
UBERON:0005476	biolink:AnatomicalEntity	spinal nerve trunk	Trunk part of spinal nerve, where dorsal and ventral roots meet to form the spinal nerve, before branching off to dorsal and ventral rami.	EHDAA2:0001900|FMA:5929	hp.json	spinal neural trunk|trunk of spinal nerve|spinal nerve (trunk)	http://purl.obolibrary.org/obo/UBERON_0005476		
CHEBI:32678	biolink:ChemicalSubstance	glutaminate	An alpha-amino-acid anion that is the conjugate base of glutamine, arising from deprotonation of the carboxy group.	Gmelin:464703	hp.json	2,5-diamino-5-oxopentanoate|glutaminate|glutamine anion|gln(-)	http://purl.obolibrary.org/obo/CHEBI_32678		3_STAR
CHEBI:32679	biolink:ChemicalSubstance	glutaminium	An alpha-amino-acid cation that is the conjugate acid of glutamine, arising from protonation of the amino group.		hp.json	glutamine cation|glutaminium|4-amino-1-carboxy-4-oxobutan-1-aminium|H2gln(+)	http://purl.obolibrary.org/obo/CHEBI_32679		3_STAR
HP:0025123	biolink:PhenotypicFeature	White streaks/specks on enamel.	Areas of white discoloration visible on the surface of the teeth (enamel) in the form of streaks or specks.		hp.json		http://purl.obolibrary.org/obo/HP_0025123		
HP:0001178	biolink:PhenotypicFeature	Ulnar claw	An abnormal hand position characterized by hyperextension of the fourth and fifth fingers at the metacarpophalangeal joints and flexion of the interphalangeal joints of the same fingers such that they are curled towards the palm.	UMLS:C4025799	hp.json		http://purl.obolibrary.org/obo/HP_0001178		
UBERON:0005463	biolink:AnatomicalEntity	subcapsular sinus of lymph node	A space between the capsule and the cortex which allows the free movement of lymphatic fluid and so contains a sparsity of lymphocytes. It is continuous with the similar lymph sinuses that flank the trabeculae.	FMA:312355|UMLS:C1518052|MA:0003027|NCIT:C33642|NCIT:C33033|UMLS:C1518051|EMAPA:37662	hp.json	marginal sinus|marginal sinus of lymph node|subcapsular sinus|lymph sinus|lymph path|lymph node subcortical sinus	http://purl.obolibrary.org/obo/UBERON_0005463		human_reference_atlas
HP:0025124	biolink:PhenotypicFeature	Fragile teeth	A tendency of teeth to fracture as manifested by a history of repeated fracture of the dental enamel without adequate trauma.		hp.json	Enamel with tendency to chip|Spontaneous tooth fracture	http://purl.obolibrary.org/obo/HP_0025124		
HP:0001176	biolink:PhenotypicFeature	Large hands		UMLS:C0426870|SNOMEDCT_US:249752003	hp.json	large hand|Disproportionately large hands|Large hands	http://purl.obolibrary.org/obo/HP_0001176		
UBERON:0005462	biolink:AnatomicalEntity	lower back	Subdivision of abdominal segment of trunk which in humans is demarcated from the front of the abdomen by the posterior surface of the anterior layer of the thoracolumbar fascia and the anterior surface of the lumbar vertebral column; together with the front of the abdomen, it constitutes the abdomen[Modified from FMA].	MA:0000027|UMLS:C0024090|BTO:0001505|NCIT:C34004|EMAPA:36623|FMA:61681	hp.json	abdominal back|lumbar part of back|lombus|lumbar region of back|lumbos|regio lumbalis|dorsum of abdomen|posterior part of abdomen|loin|lower back|lumbar region|back of abdomen	http://purl.obolibrary.org/obo/UBERON_0005462		
HP:0025125	biolink:PhenotypicFeature	White lesion of the oral mucosa	White lesions of the oral mucosa are generally caused by a condition that increases the thickness of the epithelium. This increases the distance to the vascular bed and thereby tends to change the usual reddish color of the oral mucosa to white. Common causes include hyperkeratosis (thickening of the keratin layer), acanthosis (thickening of the spinous cell layer), increased edema in the epithelium (leukoedema), and reduced vascularity of the underlying lamina propria. Additionally, fibrin caps or surface ulcerations and collapsed bullae can appear white.		hp.json		http://purl.obolibrary.org/obo/HP_0025125		
UBERON:0005461	biolink:AnatomicalEntity	levator scapulae muscle	An axial muscle that originates in the cervical vertebraae inserts on the scapula.	FMA:32519|EHDAA:8309|AAO:0010689|EHDAA2:0000992	hp.json	levator scapulae muscle|levator scapulae|levator scapulæ|musculus levator scapulae|levator scapula	http://purl.obolibrary.org/obo/UBERON_0005461		pheno_slim
HP:0001177	biolink:PhenotypicFeature	Preaxial hand polydactyly	Supernumerary digits located at the radial side of the hand. Polydactyly (supernumerary digits) involving the thumb occurs in many distinct forms of high variability and severity. Ranging from fleshy nubbins over varying degrees of partial duplication/splitting to completely duplicated or even triplicated thumbs or preaxial (on the radial side of the hand) supernumerary digits.	MSH:C536332|SNOMEDCT_US:205135003|UMLS:C1395852|SNOMEDCT_US:445216006	hp.json	Preaxial polydactyly of hands|thumb polydactyly|Polydactyly affecting the thumb|Supernumerary thumb|Extra thumb	http://purl.obolibrary.org/obo/HP_0001177		
HP:0025126	biolink:PhenotypicFeature	Oral hairy leukoplakia	A corrugated white lesion of the oral mucosa that usually occurs on the lateral or ventral surfaces of the tongue and may have a shaggy or frayed appearance.		hp.json		http://purl.obolibrary.org/obo/HP_0025126		
UBERON:0005460	biolink:AnatomicalEntity	left vitelline vein	A vitelline vein that is in the left side of a multicellular organism.	FMA:70307|EMAPA:16698|EHDAA2:0000971|EMAPA:16380|SCTID:361446008	hp.json		http://purl.obolibrary.org/obo/UBERON_0005460		
HP:0025127	biolink:PhenotypicFeature	Actinic keratosis	A scaly, crusty lesion caused by damage from the ultraviolet radiation of the sun, with typical location on sun-exposed areas of the skin. Actinic keratosis lesions are often elevated, rough, and wartlike, and may be red, or occasionally tan, pink, or flesh-toned in color.		hp.json	Solar keratosis	http://purl.obolibrary.org/obo/HP_0025127		
HP:0025128	biolink:PhenotypicFeature	Reduced intraabdominal adipose tissue	An abnormally reduced amount of adipose tissue in the abdominal cavity.		hp.json		http://purl.obolibrary.org/obo/HP_0025128		
HP:0025129	biolink:PhenotypicFeature	Abnormal small intestinal mucosa morphology	A structural anomaly of the mucous lining of the small intestine.		hp.json		http://purl.obolibrary.org/obo/HP_0025129		
HP:0001171	biolink:PhenotypicFeature	Split hand	A condition in which middle parts of the hand (fingers and metacarpals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic middle fingers over absent middel fingers as far as oligo- or monodactyl hands.	UMLS:C0221373|SNOMEDCT_US:299034005	hp.json	Split-hand|Hand ectrodactyly|Ectrodactyly of the hand|Split hand	http://purl.obolibrary.org/obo/HP_0001171		
UBERON:0005469	biolink:AnatomicalEntity	right thymus lobe	A thymus lobe that is in the right side of a thymus.	RETIRED_EHDAA2:0001758|FMA:71194	hp.json	right thymic lobe|right lobe of thymus	http://purl.obolibrary.org/obo/UBERON_0005469		
CHEBI:17012	biolink:ChemicalSubstance	N-acetylneuraminic acid	An N-acylneuraminic acid where the N-acyl group is specified as acetyl.	PMID:18487279|GlyTouCan:G81533KY|PMID:19329108|Beilstein:2951361|GlyGen:G81533KY|CAS:131-48-6|CAS:131-48-6|PMID:14960498|PMID:16624269|Reaxys:1398688|PMID:7508418|KNApSAcK:C00019584|KEGG:C00270|Wikipedia:N-acetylneuraminic_acid|PMID:8448384|PMID:16209099	hp.json	5-acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonic acid|acide aceneuramique|5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-2-nonulosonic acid|aceneuramic acid|acido aceneuramico|N-Acetylneuraminic acid|Aceneuramic acid|WURCS=2.0/1,1,0/[Aad21122h-2x_2-6_5*NCC/3=O]/1/|O-sialic acid|acidium aceneuramicum|NeuAc|Neu5Ac	http://purl.obolibrary.org/obo/CHEBI_17012		3_STAR
UBERON:0005467	biolink:AnatomicalEntity	platysma	The platysma is a pharyngeal arch 2 muscle and a superficial facial muscle that participates in oral/pharyngeal behaviors and is innervated by the cervical branch of the facial nerve. It attaches to the mandible and it attaches to the skin of the head, neck, and thoracic region where it is found superficial to the clavicle. Burrows et al. (2011) argue that in hylobatids (and, presumably, other primates) the platysma in the region of the modiolus represents both the cervicale and myoides muscles.	MFMO:0000059|UMLS:C1514163|EMAPA:18190|NCIT:C33329|BTO:0005124|EHDAA:8270|FMA:45738|MA:0003026|EHDAA2:0001474|VHOG:0000931	hp.json	platysma muscle|platysma myoides|platysma cervicale|neck platysma muscle	http://purl.obolibrary.org/obo/UBERON_0005467		
HP:0025121	biolink:PhenotypicFeature	obsolete Simple partial occipital seizures			hp.json		http://purl.obolibrary.org/obo/HP_0025121		
HP:0001172	biolink:PhenotypicFeature	Abnormal thumb morphology	An abnormal structure of the first digit of the hand.	SNOMEDCT_US:299130003|MSH:C536903|UMLS:C0575897	hp.json	Thumb deformity|Abnormality of the thumbs|Abnormality of the thumb	http://purl.obolibrary.org/obo/HP_0001172		
UBERON:0005465	biolink:AnatomicalEntity	obturator nerve	The obturator nerve arises from the ventral divisions of the second, third, and fourth lumbar nerves; the branch from the third is the largest, while that from the second is often very small.	MESH:D009776|EHDAA2:0001282|FMA:16487|EHDAA:5657|NCIT:C75909|UMLS:C0028783	hp.json	nervus obturatorius	http://purl.obolibrary.org/obo/UBERON_0005465		
HP:0025122	biolink:PhenotypicFeature	Sawtooth acanthosis	A type of epidermal acanthosis characterized by a jagged (sawtooth) appearance of the rete ridges of the epidermis.		hp.json	Sawtoothed acanthosis	http://purl.obolibrary.org/obo/HP_0025122		
CHEBI:20664	biolink:ChemicalSubstance	5beta-cholane		Beilstein:2048472	hp.json	5beta-cholane	http://purl.obolibrary.org/obo/CHEBI_20664		3_STAR
CHEBI:32646	biolink:ChemicalSubstance	methioninium	A sulfur-containing amino-acid anion that is the conjugate acid of methionine, arising from protonation of the amino group.	Gmelin:326567	hp.json	H2met(+)|methioninium|methionine cation|1-carboxy-3-(methylsulfanyl)propan-1-aminium	http://purl.obolibrary.org/obo/CHEBI_32646		3_STAR
PR:O54990	biolink:Protein	prominin-1 (mouse)	A prominin-1 that is encoded in the genome of mouse.	UniProtKB:O54990	hp.json	Proml1|CD133 (mouse)|Prom1|prominin-like protein 1 (mouse)|Prom|antigen AC133 homolog (mouse)|mPROM1	http://purl.obolibrary.org/obo/PR_O54990		
CHEBI:68641	biolink:ChemicalSubstance	(-)-cotinine	An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum.	Wikipedia:Cotinine|PMID:23000417|PMID:22460317|Reaxys:5736575|PMID:22180597|PMID:22489581|PMID:22871902|PMID:22487419|PMID:22899265|Drug_Central:737|PMID:22200307|PMID:22027507|PMID:23011941|PMID:23087643|LINCS:LSM-5986|PMID:22770225|PMID:22574797|PMID:21655912|PMID:22919158|PMID:22434216|KNApSAcK:C00034470|PMID:22253001|PMID:14700346|PMID:22137886|PMID:22169225|Reaxys:83099|PMID:22809871|PMID:22687995|PMID:22608097|MetaCyc:CPD-2742|PMID:21953524|CAS:486-56-6|PMID:22878732|PMID:22244928|HMDB:HMDB0001046|PMID:22678157	hp.json	(S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone|(S)-(-)-Cotinine|cotinine|cotinina|(S)-Cotinine|(5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one|cotininum|cotinine	http://purl.obolibrary.org/obo/CHEBI_68641		3_STAR
HP:0025112	biolink:PhenotypicFeature	Sound sensitivity	Decreased tolerance to sound.		hp.json	Noise sensitivity	http://purl.obolibrary.org/obo/HP_0025112		
HP:0001145	biolink:PhenotypicFeature	obsolete Chorioretinopathy			hp.json		http://purl.obolibrary.org/obo/HP_0001145		
HP:0001146	biolink:PhenotypicFeature	obsolete Pigmentary retinal degeneration			hp.json		http://purl.obolibrary.org/obo/HP_0001146		
HP:0025113	biolink:PhenotypicFeature	Misophonia	An adverse response (dislike) to sound no matter what volume the sound is, characterized by a strong negative reaction to soft sounds that can sometimes be further triggered by seeing the source of the offending sound.		hp.json		http://purl.obolibrary.org/obo/HP_0025113		
UBERON:0005451	biolink:AnatomicalEntity	segment of manus	A segment of autopod that is part of a manus.	FMA:24945	hp.json	regio manus|hand subdivision|segment of hand|hand region|subdivision of hand	http://purl.obolibrary.org/obo/UBERON_0005451		pheno_slim
HP:0025114	biolink:PhenotypicFeature	Hypergranulosis	Hypergranulosis is an increased thickness of the stratum granulosum.		hp.json		http://purl.obolibrary.org/obo/HP_0025114		
HP:0001144	biolink:PhenotypicFeature	Orbital cyst	Presence of a cyst in the region of the periorbital tissues. Orbital cysts can be derived from epithelial or glandular tissue within or surrounding the orbit (lacrimal glands, salivary glands, conjunctival, oral, nasal, or sinus epithelium).	SNOMEDCT_US:31021007|UMLS:C0155285	hp.json	Cyst of eye socket|Orbital cysts	http://purl.obolibrary.org/obo/HP_0001144		
HP:0025115	biolink:PhenotypicFeature	Civatte bodies	Eosinophilic hyaline ovoid bodies which are often found in the subepidermal papillary regions or sometimes in the epidermis. Civatte bodies (CBs) are seen as rounded, homogenous, eosinophilic masses on routine H and E staining lying in the deeper parts of epidermis/epithelium and more frequently in dermis/connective tissue. They are known as CBs (in epithelium/epidermis), colloid bodies, or hyaline bodies (in connective tissue). They are 10-25 micrometers in diameter and situated mostly within or above the inflammatory cell infiltrate. In lichen planus, the number of necrotic keratinocytes may be so large that they are seen lying in clusters in the uppermost dermis. These bodies show a positive periodic acid Schiff reaction and are diastase resistant		hp.json	Hyaline bodies|Colloid bodies of Civatte|Cytoid bodies|Colloid bodies	http://purl.obolibrary.org/obo/HP_0025115		
HP:0001149	biolink:PhenotypicFeature	Lattice corneal dystrophy	The presence of fine, branching linear opacities in Bowman's layer in the central area that may spread to the periphery in the clinical course. The deep corneal stroma may be involved but the process does not reach Descemet's membrane. Recurrent corneal erosion may occur. Histologic examination reveals amyloid deposits in the collagen fibers of the cornea.	SNOMEDCT_US:361199007|UMLS:C0155127|MSH:D028227|SNOMEDCT_US:1192004	hp.json	Biber haab dimmer dystrophy	http://purl.obolibrary.org/obo/HP_0001149		
HP:0025116	biolink:PhenotypicFeature	Fetal distress	An intrauterine state characterized by suboptimal values in the fetal heart rate, oxygenation of fetal blood, or other parameters indicative of compromise of the fetus. Signs of fetal distress include repetitive variable decelerations, fetal tachycardia or bradycardia, late decelerations, or low biophysical profile.		hp.json	Foetal distress	http://purl.obolibrary.org/obo/HP_0025116		
HP:0025117	biolink:PhenotypicFeature	Rete ridge flattening	Rete pegs (or ridges) are the epithelial extensions that project into the underlying connective tissue in both skin and mucous membranes. Rete ridge flattening refers to the loss of these projections so that the skin epithelium acquires a relatively flat appearance.		hp.json	Flattened rete pegs|Flattened rete ridges	http://purl.obolibrary.org/obo/HP_0025117		
HP:0025118	biolink:PhenotypicFeature	Lip discoloration	Lightening or darkening of the lips from their usual coloring.		hp.json		http://purl.obolibrary.org/obo/HP_0025118		
HP:0001147	biolink:PhenotypicFeature	Retinal exudate	Fluid which has escaped from retinal blood vessels with a high concentration of lipid, protein, and cellular debris with a typically bright, reflective, white or cream colored appearance on the surface of the retina.	UMLS:C0240897|SNOMEDCT_US:39832008	hp.json	Retinal exudates	http://purl.obolibrary.org/obo/HP_0001147		
CHEBI:32644	biolink:ChemicalSubstance	methioninate	A sulfur-containing amino-acid anion that is the conjugate base of methionine, arising from deprotonation of the carboxy group.	Beilstein:3937270|Reaxys:3937270|Gmelin:326565	hp.json	2-amino-4-(methylsulfanyl)butanoate|met(-)|methioninate|methionine anion	http://purl.obolibrary.org/obo/CHEBI_32644		3_STAR
HP:0025119	biolink:PhenotypicFeature	Violet lip discoloration	An alteration of the color of the lip to take on a violet color. This term does not include cyanosis.		hp.json		http://purl.obolibrary.org/obo/HP_0025119		
UBERON:0005458	biolink:AnatomicalEntity	left umbilical artery		VHOG:0000522|FMA:18822|EHDAA2:0000966|EMAPA:16544	hp.json	embryonic left umbilical artery	http://purl.obolibrary.org/obo/UBERON_0005458		
HP:0001141	biolink:PhenotypicFeature	Severely reduced visual acuity	Severe reduction of the ability to see defined as visual acuity less than 6/60 (20/200 in US notation; 0.1 in decimal notation) but at least 3/60 (20/400 in US notation; 0.05 in decimal notation).	SNOMEDCT_US:397541004|UMLS:C1301509	hp.json	Severe reduction in visual acuity|Severe visual loss|Severe visual impairment|Marked vision impairment|Severely impaired vision|Severe vision loss	http://purl.obolibrary.org/obo/HP_0001141		
UBERON:0005457	biolink:AnatomicalEntity	left thymus lobe	A thymus lobe that is in the left side of a thymus.	RETIRED_EHDAA2:0000964|FMA:71195	hp.json	left lobe of thymus|left thymic lobe	http://purl.obolibrary.org/obo/UBERON_0005457		
UBERON:0005456	biolink:AnatomicalEntity	jugular foramen	The jugular foramen is a large aperture in the base of the skull. It is located behind the carotid canal and is formed in front by the petrous portion of the temporal, and behind by the occipital; it is generally larger on the right than on the left side.	NCIT:C12496|VHOG:0001113|FMA:56432|EMAPA:18713|UMLS:C0222712|SCTID:361735006|Wikipedia:Jugular_foramen|EHDAA:10631|MESH:D000080869|AAO:0000249|EHDAA2:0000893	hp.json	Posterior lacerate foramen|foramen jugulare|foramen jugulare	http://purl.obolibrary.org/obo/UBERON_0005456		
HP:0001142	biolink:PhenotypicFeature	Lenticonus	A conical projection of the anterior or posterior surface of the lens, occurring as a developmental anomaly.	SNOMEDCT_US:253221000|UMLS:C0239119	hp.json		http://purl.obolibrary.org/obo/HP_0001142		hposlim_core
HP:0025110	biolink:PhenotypicFeature	Placoid macular lesion	Yellow/white, sharply delineated lesion, typically of inflammatory nature, involving the macula.		hp.json		http://purl.obolibrary.org/obo/HP_0025110		
HP:0001140	biolink:PhenotypicFeature	Limbal dermoid	A benign tumor typically found at the junction of the cornea and sclera (limbal epibullar dermoid).	UMLS:C1867616|SNOMEDCT_US:92097004|SNOMEDCT_US:5131000119107|UMLS:C0496897	hp.json	Epibulbar dermoid|Benign eye tumor|Epibulbar dermoids|Benign eye tumour	http://purl.obolibrary.org/obo/HP_0001140		hposlim_core
UBERON:0005454	biolink:AnatomicalEntity	abdominal internal oblique muscle	The lateral abdominal wall muscle that is deep to the external oblique and superficial to the transversus.	NCIT:C32857|EHDAA2:0000879|UMLS:C1512878|FMA:13891|EHDAA:8250|MA:0002346|VHOG:0000789|EMAPA:18163	hp.json	obliquus internus abdominis muscle|abdominal internal oblique|obliqui internus|musculus obliquus internus abdominis|obliquus internus abdominis|obliquus internus abdominis|internal oblique|abdominal internal oblique muscle|internal oblique muscle|obliquus internus abdominis muscle|internal oblique abdominis muscle|internal abdominal oblique muscle|internal oblique abdominal|internal abdominal oblique|internal oblique abdominis|obliquus internus abdominis|obliquus internus	http://purl.obolibrary.org/obo/UBERON_0005454		organ_slim
PR:P01731	biolink:Protein	T-cell surface glycoprotein CD8 alpha chain (mouse)	A T-cell surface glycoprotein CD8 alpha chain that is encoded in the genome of mouse.	UniProtKB:P01731	hp.json	Lyt-2|Lyt2|Cd8a|CD8a (mouse)|mCD8A|T-cell surface glycoprotein Lyt-2 (mouse)	http://purl.obolibrary.org/obo/PR_P01731		
CHEBI:32656	biolink:ChemicalSubstance	D-asparaginate		Gmelin:533547	hp.json	(2R)-2,4-diamino-4-oxobutanoate|D-asparaginate|D-asparagine anion	http://purl.obolibrary.org/obo/CHEBI_32656		3_STAR
HP:0025109	biolink:PhenotypicFeature	Reduced red cell pyruvate kinase level	Decrease in the level of pyruvate kinase (PK) within erythrocytes. PK catalyzes the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate.		hp.json	Reduced erythrocyte pyruvate kinase activity	http://purl.obolibrary.org/obo/HP_0025109		
CHEBI:32657	biolink:ChemicalSubstance	D-asparaginium			hp.json	(1R)-3-amino-1-carboxy-3-oxopropan-1-aminium|D-asparaginium|D-asparagine cation	http://purl.obolibrary.org/obo/CHEBI_32657		3_STAR
UBERON:0005442	biolink:AnatomicalEntity	abdominal external oblique muscle	The lateral abdominal wall muscle that is the most superficial, immediately superficial to the internal oblique.	VHOG:0000788|EHDAA:8248|UMLS:C0224375|EMAPA:18162|FMA:13335|NCIT:C32567|EHDAA2:0000469|MA:0002345	hp.json	oblique strength|external oblique abdominal muscles|external abdominal oblique|external oblique abdominis|external oblique|obliquus externus|obliquus abdominis externus|external abdominal oblique muscle|obliquus externus abdominis|obliquus externus abdominis|external oblique muscle|abdominal external oblique muscle|obliquus externus abdominis muscle|external oblique abdominis muscle|external abdominal oblique muscle|external oblique|m. obliquus externus abdominis	http://purl.obolibrary.org/obo/UBERON_0005442		organ_slim
HP:0001156	biolink:PhenotypicFeature	Brachydactyly	Digits that appear disproportionately short compared to the hand/foot. The word brachydactyly is used here to describe a series distinct patterns of shortened digits (brachydactyly types A-E). This is the sense used here.	UMLS:C0221357|SNOMEDCT_US:43476002|MSH:D059327	hp.json	Brachydactyly syndrome|Short fingers or toes	http://purl.obolibrary.org/obo/HP_0001156		
HP:0025101	biolink:PhenotypicFeature	Dysgenesis of the hippocampus	Structural abnormality of the hippocampus related to defective development.		hp.json	Hippocampal dysgenesis	http://purl.obolibrary.org/obo/HP_0025101		
HP:0025102	biolink:PhenotypicFeature	Dysgenesis of the basal ganglia	Structural abnormality of the basal ganglia related to defective development.		hp.json	Basal ganglia dysgenesis	http://purl.obolibrary.org/obo/HP_0025102		
HP:0025103	biolink:PhenotypicFeature	Umbilicated nodule	A type of skin nodule that has a small depression that resembles a navel (i.e., is umbilicated).		hp.json		http://purl.obolibrary.org/obo/HP_0025103		
UBERON:0005440	biolink:AnatomicalEntity	ductus arteriosus	A fetal blood vessel connecting the pulmonary artery with the descending aorta[MESH]. In the developing fetus, the ductus arteriosus is a shunt connecting the pulmonary artery to the aortic arch. It allows most of the blood from the right ventricle to bypass the fetus' fluid-filled lungs, protecting the lungs from being overworked and allowing the left ventricle to strengthen. There are two other fetal shunts, the ductus venosus and the foramen ovale[MP]. the fetal vessel that connects the left pulmonary artery with the descending aorta; the ductus arteriosus normally regresses into a fibrous cord, the ligamentum arteriousum after birth[MP].	EMAPA:17858|MA:0001947|EHDAA:6462|MESH:D004373|NCIT:C52854|FMA:79871|UMLS:C0013273|EFO:0002515|galen:DuctusArteriosus|VHOG:0000923|EHDAA2:0000420	hp.json	ductus arteriosum|Botallo's duct|ductus layton|ductus botalli|arterial canal|arterial duct|fetal ductus arteriosus|ductus Botallo|ductus arteriosis	http://purl.obolibrary.org/obo/UBERON_0005440		efo_slim|pheno_slim
CHEBI:32650	biolink:ChemicalSubstance	L-asparaginate	An optically active form of asparaginate having L-configuration.	HMDB:HMDB0000168|Reaxys:6115348|Beilstein:6115348|Gmelin:327371	hp.json	L-asparaginate|(2S)-2,4-diamino-4-oxobutanoate|L-asparagine anion	http://purl.obolibrary.org/obo/CHEBI_32650		3_STAR
CHEBI:32651	biolink:ChemicalSubstance	L-asparaginium			hp.json	(1S)-3-amino-1-carboxy-3-oxopropan-1-aminium|L-asparaginium|L-asparagine cation	http://purl.obolibrary.org/obo/CHEBI_32651		3_STAR
HP:0001155	biolink:PhenotypicFeature	Abnormality of the hand	An abnormality affecting one or both hands.	MSH:D006226|UMLS:C0018564|SNOMEDCT_US:299033004	hp.json	Abnormal hands|Hand deformities|Hand anomalies|Abnormality of the hand	http://purl.obolibrary.org/obo/HP_0001155		hposlim_core
HP:0025104	biolink:PhenotypicFeature	Capillary malformation	A capillary malformation is a flat, sharply defined vascular stain of the skin. It may cover a large surface area or it may be scattered and appear as little islands of color. In a capillary maformation, the predominant vessels are small, slow-flow vessels (i.e., arterioles and postcapillary venules).		hp.json		http://purl.obolibrary.org/obo/HP_0025104		
HP:0025105	biolink:PhenotypicFeature	Nevus anemicus	A congenital skin lesion characterized by irregular hypopigmented macules that coalesce to form plaques and occur particularly on the chest. It is generally present at birth or develops in the first days of life. It is more common in females. Diagnosis is confirmed by applying gentle friction to the lesion and the surrounding skin and checking that the erythema produced in the healthy skin does not appear in the hypopigmented lesion. This pale macule becomes more conspicuous when the lesion and its surroundings are rubbed. The margin of the naevus is ill-defined and consists of an archipelago of small anaemic spots.		hp.json	Naevus anaemicus	http://purl.obolibrary.org/obo/HP_0025105		
HP:0025106	biolink:PhenotypicFeature	Nevus roseus	A variant of port-wine stain characterized by a pale red or even pink tone, in contrast to the darker hue of the port-wine stain. By analogy with the term port-wine stain, this variant rose-wine stain, or nevus roseus. Nevus roseus, however, cannot be definitely diagnosed until adulthood as port-wine stains are sometimes pink in children. While the natural history of port-wine stains includes hypertrophy, darkening, and nodularity, nevus roseus remains unchanged for life.		hp.json		http://purl.obolibrary.org/obo/HP_0025106		
HP:0025107	biolink:PhenotypicFeature	Cutis marmorata telangiectatica congenita	A congenital vascular malformation that presents as localized or generalized erythematous-telangiectatic lesions with a reticular pattern; the lesions are almost always present at birth or develop in the first days of life. Cutis marmorata telangiectatica congenita (CMTC) appears as marble-like pattern (mottling) on the surface of the skin. In contrast to cutis marmorata, the marbling is more severe and always visible.		hp.json		http://purl.obolibrary.org/obo/HP_0025107		
HP:0001159	biolink:PhenotypicFeature	Syndactyly	Webbing or fusion of the fingers or toes, involving soft parts only or including bone structure. Bony fusions are referred to as "bony" syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers or toes in a proximo-distal axis are referred to as "symphalangism".	Fyler:4174|MSH:D013576|SNOMEDCT_US:373413006|UMLS:C0039075	hp.json	Webbed fingers or toes	http://purl.obolibrary.org/obo/HP_0001159		
HP:0025108	biolink:PhenotypicFeature	Angioma serpentinum	Angioma serpiginosum consists of punctate, tightly packed telangiectatic lesions. Characteristic histopathological features are dilated and tortuous capillaries involving the uppermost part of the dermis.		hp.json		http://purl.obolibrary.org/obo/HP_0025108		
UBERON:0005446	biolink:AnatomicalEntity	foramen rotundum	The foramen rotundum is a circular hole in the sphenoid bone that connects the middle cranial fossa and the pterygopalatine fossa.	EHDAA2:0000552|EHDAA:10629|VHOG:0001543|FMA:53154|AAO:0000194|EMAPA:18712	hp.json	foramen rotundum of the skull|round foramen|foramen rotundum ossis sphenoidalis	http://purl.obolibrary.org/obo/UBERON_0005446		
HP:0001152	biolink:PhenotypicFeature	Saccadic smooth pursuit	An abnormality of tracking eye movements in which smooth pursuit is interrupted by an abnormally high number of saccadic movements.	UMLS:C1836479	hp.json	Saccadic pursuit movements|Saccadic slow pursuit	http://purl.obolibrary.org/obo/HP_0001152		
UBERON:0005445	biolink:AnatomicalEntity	segment of pes	A segment of autopod that is part of a pes.	FMA:24993	hp.json	regio pedis|subdivision of foot|foot subdivision|foot region|segment of foot	http://purl.obolibrary.org/obo/UBERON_0005445		pheno_slim
HP:0001153	biolink:PhenotypicFeature	Septate vagina	The presence of a vaginal septum, thereby creating a vaginal duplication. The septum is longitudinal in the majority of cases.	UMLS:C0266411|SNOMEDCT_US:47054003	hp.json	Double vagina	http://purl.obolibrary.org/obo/HP_0001153		
HP:0001150	biolink:PhenotypicFeature	obsolete Choroidal sclerosis			hp.json		http://purl.obolibrary.org/obo/HP_0001150		
HP:0025100	biolink:PhenotypicFeature	Abnormal hippocampus morphology	Any structural anomaly of the hippocampus,		hp.json	Abnormal morphology of the hippocampus|Abnormality of hippocampus morphology	http://purl.obolibrary.org/obo/HP_0025100		
HP:0001151	biolink:PhenotypicFeature	Impaired horizontal smooth pursuit	An abnormality of ocular smooth pursuit characterized by an impairment of the ability to track horizontally moving objects.	UMLS:C1866753	hp.json	Abnormal horizontal ocular pursuit|Impaired horizontal visual pursuit	http://purl.obolibrary.org/obo/HP_0001151		
HP:0025180	biolink:PhenotypicFeature	Centrilobular ground-glass opacification on pulmonary HRCT	A hazy area of increased attenuation in centrilobular areas of the lung with preserved bronchial and vascular markings seen on a computer tomography scan. Centrilobular refers to a location that is central within secondary pulmonary lobules.		hp.json	Centrilobular groundglass opacity|Centrilobular groundglass opacification	http://purl.obolibrary.org/obo/HP_0025180		
CHEBI:32627	biolink:ChemicalSubstance	leucinate	An alpha-amino-acid anion that is the conjugate base of leucine, arising from deprotonation of the carboxy group.	Reaxys:5245805	hp.json	2-amino-4-methylpentanoate|leu(-)|leucinate|leucine anion	http://purl.obolibrary.org/obo/CHEBI_32627		3_STAR
CHEBI:32628	biolink:ChemicalSubstance	leucinium	An alpha-amino-acid cation that is the conjugate acid of leucine, arising from protonation of the amino group.	Gmelin:1651836	hp.json	leucine cation|leucinium|1-carboxy-3-methylbutan-1-aminium|H2leu(+)	http://purl.obolibrary.org/obo/CHEBI_32628		3_STAR
HP:0025178	biolink:PhenotypicFeature	Subpleural interstitial thickening	Increase in thickness of the subpleural interstitium.		hp.json	Subpleural scarring	http://purl.obolibrary.org/obo/HP_0025178		
HP:0025179	biolink:PhenotypicFeature	Ground-glass opacification	On chest radiographs, ground-glass opacity appears as an area of hazy increased lung opacity, usually extensive, within which margins of pulmonary vessels may be indistinct. On CT scans, it appears as hazy increased opacity of lung, with preservation of bronchial and vascular margins. It is caused by partial filling of airspaces, interstitial thickening (due to fluid, cells, and/or fibrosis), partial collapse of alveoli, increased capillary blood volume, or a combination of these, the common factor being the partial displacement of air. Ground-glass opacity is less opaque than consolidation, in which bronchovascular margins are obscured.		hp.json	Ground-glass opacification on pulmonary HRCT|Ground glass opacities|GGO	http://purl.obolibrary.org/obo/HP_0025179		
HP:0025170	biolink:PhenotypicFeature	Neuronal/glioneuronal neoplasm of the central nervous system	A central nervous system neoplasm with neuronal and, less consistently, glial differentiation.		hp.json	Neuronal and mixed neuronal-glial tumour|Neuronal and mixed neuronal-glial tumor|Neuronal/glioneuronal neoplasm of the CNS|Glioneuronal tumor|Glioneuronal tumour	http://purl.obolibrary.org/obo/HP_0025170		
HP:0025171	biolink:PhenotypicFeature	Rosette-forming glioneuronal tumor	A tumor of the central nervous system that has components of both neurocytic and glial areas, whereby usually the glial component of the tumour predominates. Rossette-forming glioneuronal tumors (RGNT) have biphasic cytoarchitecture with two elements; neurocytic rosettes resembling Homer-Wright rosettes, and astrocytic component resembling a pilocytic astrocytoma. RGNTs are low-grade tumors that lack histopathological signs of malignancy.		hp.json	Rosette-forming glioneuronal tumor of the fourth ventricle|Rosette-forming glioneuronal tumour|Rosette-forming glioneuronal tumour of the fourth ventricle|Rosette-forming glioneuronal neoplasm	http://purl.obolibrary.org/obo/HP_0025171		
HP:0025172	biolink:PhenotypicFeature	Smooth septal thickening on pulmonary HRCT	Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with a smooth appearance of the interlobular septa.		hp.json		http://purl.obolibrary.org/obo/HP_0025172		
HP:0025173	biolink:PhenotypicFeature	Nodular septal thickening on pulmonary HRCT	Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with a nodular or beaded appearance of the interlobular septa.		hp.json		http://purl.obolibrary.org/obo/HP_0025173		
PR:000005307	biolink:Protein	CCAAT/enhancer-binding protein alpha	A protein that is a translation product of the human CEBPA gene or a 1:1 ortholog thereof.		hp.json	CEBP|C/EBP alpha|CEBPA	http://purl.obolibrary.org/obo/PR_000005307		
HP:0025174	biolink:PhenotypicFeature	Irregular septal thickening on pulmonary HRCT	Thickening of the interlobular septa of the lungs as seen on a high-resolution computed tomography scan with an irregular appearance of the interlobular septa. THis feature is often associated with distortion of lung architecture.		hp.json		http://purl.obolibrary.org/obo/HP_0025174		
HP:0025175	biolink:PhenotypicFeature	Honeycomb lung	Honeycombing represents destroyed and fibrotic lung tissue containing numerous cystic airspaces with thick fibrous walls, representing the late stage of various lung diseases, with complete loss of acinar architecture. The cysts range in size from a few millimeters to several centimeters in diameter, have variable wall thickness, and are lined by metaplastic bronchiolar epithelium. On chest radiographs, honeycombing appears as closely approximated ring shadows, typically 3-10 mm in diameter with walls 1-3 mm in thickness, that resemble a honeycomb; the finding implies end-stage lung disease. On CT scans, the appearance is of clustered cystic air spaces, typically of comparable diameters on the order of 3-10 mm but occasionally as large as 2.5 cm. Honeycombing is usually subpleural and is characterized by well-defined walls. It is a CT feature of established pulmonary fibrosis. Because honeycombing is often considered specific for pulmonary fibrosis and is an important criterion in the diagnosis of usual interstitial pneumonia, the term should be used with care, as it may directly impact patient care.		hp.json	Honeycombing|Honeycomb cysts	http://purl.obolibrary.org/obo/HP_0025175		
HP:0025176	biolink:PhenotypicFeature	Intralobular interstitial thickening	A fine reticular pattern on high-resolution computed tomography, with the visible lines separated by a few millimeters. Regions of the lung with intralobular interstitial thickening characteristically show a fine lacelike or netlike appearance.		hp.json		http://purl.obolibrary.org/obo/HP_0025176		
HP:0025177	biolink:PhenotypicFeature	Peribronchovascular interstitial thickening	Thickening of the peribronchovascular interstitium, a connective tissue sheath that surrounds the central bronchi and pulmonary arteries. The peribronchovascular interstitium extends from the level of the pulmonary hila into the peripheral lung. This feature may be ascertained on high-resolution computer tomography.		hp.json		http://purl.obolibrary.org/obo/HP_0025177		
HP:0025167	biolink:PhenotypicFeature	Fragmented elastic fibers in the dermis	Elastic fibers in the dermis exhibit an increased number of breaks associated with disorganization of the structure of the elastic fibers.		hp.json	Fragmented elastic fibres in the dermis	http://purl.obolibrary.org/obo/HP_0025167		
HP:0025168	biolink:PhenotypicFeature	Left ventricular diastolic dysfunction	Abnormal function of the left ventricule during left ventricular relaxation and filling.		hp.json		http://purl.obolibrary.org/obo/HP_0025168		
HP:0025169	biolink:PhenotypicFeature	Left ventricular systolic dysfunction	Abnormality of left ventricular contraction, often defined operationally as an ejection fraction of less than 40 percent.		hp.json		http://purl.obolibrary.org/obo/HP_0025169		
PR:000007975	biolink:Protein	cobalamin binding intrinsic factor	A protein that is a translation product of the human CBLIF gene or a 1:1 ortholog thereof.		hp.json	INF|IFMH|IF|CBLIF|intrinsic factor|GIF|gastric intrinsic factor	http://purl.obolibrary.org/obo/PR_000007975		
HP:0025160	biolink:PhenotypicFeature	Abnormal temper tantrums	A temper tantrum is an emotional outburst usually triggered by a sense of frustration and manifested as whining and crying, screaming, kicking, hitting, and breath holding. Temper tantrums are normal in toddlers and young children and usually happen between the ages of one to three years. Temper tantrums may be considered abnormal if they occur at an unusually high frequency, are of unusual severity, or occur at an old age than usual.		hp.json		http://purl.obolibrary.org/obo/HP_0025160		
HP:0025161	biolink:PhenotypicFeature	Frequent temper tantrums	Temper tantrums that occur more frequently than usual.		hp.json		http://purl.obolibrary.org/obo/HP_0025161		
HP:0025162	biolink:PhenotypicFeature	Severe temper tantrums	Temper tantrums whose severity is more severe than usual. For instance, a temper tantrum might be considered to be severe if a child loses control so completely that the child cannot control the tantrum on its own, continuing until it becomes exhausted or a parent intervenes.		hp.json		http://purl.obolibrary.org/obo/HP_0025162		
HP:0025163	biolink:PhenotypicFeature	Abnormality of optic chiasm morphology	A structural abnormality of the optic chiasm.The optic chiasm, located below the hypothalamus, is a partial crossing of the optic nerves.		hp.json		http://purl.obolibrary.org/obo/HP_0025163		
HP:0025164	biolink:PhenotypicFeature	Increased number of elastic fibers in the dermis	An elevated number of elastic fibers, that is of bundles of proteins and glycoproteins in the extracellular matrix in the reticular dermis. Elastic fibers can stretch and recoil back to their original length. This feature can be appreciated on histology with hematoxylin and eosin or other staining methods.		hp.json	Increased number of elastic fibres in the dermis	http://purl.obolibrary.org/obo/HP_0025164		
HP:0025165	biolink:PhenotypicFeature	Clumping of elastic fibers in the dermis	Formation of clumps or aggregates that make up small protuberances from elastic fibers within the dermis (especially the reticular dermis).		hp.json	Clumping of elastic fibres in the dermis	http://purl.obolibrary.org/obo/HP_0025165		
HP:0025166	biolink:PhenotypicFeature	Thickened elastic fibers in the dermis	An increase of the diameter of elastic fibers in the dermis.		hp.json	Thickened elastic fibres in the dermis	http://purl.obolibrary.org/obo/HP_0025166		
UBERON:0005497	biolink:AnatomicalEntity	non-neural ectoderm		XAO:0004091|VHOG:0001372|ZFA:0001178|EHDAA:257|RETIRED_EHDAA2:0001273|TAO:0001178|EMAPA:16074|EFO:0003643	hp.json	epidermal ectoderm|ventral ectoderm|surface ectoderm|epidermal ectoderm|epithelial ectoderm|surface ectoderm|non neural ectoderm|epithelial ectoderm	http://purl.obolibrary.org/obo/UBERON_0005497		vertebrate_core|efo_slim
HP:0025156	biolink:PhenotypicFeature	Dependency on intravenous nutrition	Inability to be weaned from intravenous (parenteral) nutrition, as judged by the hydration status (urine output, blood urea nitrogen, creatinine, urine sodium concentration), ability to maintain weight, stool output, and serum electrolyte status.		hp.json	Dependency on IV nutrition	http://purl.obolibrary.org/obo/HP_0025156		
UBERON:0005496	biolink:AnatomicalEntity	neural tube lateral wall	Portion of tissue on the side of the lumen of the neural tube.	TAO:0001435|EMAPA:16166|EHDAA:2873|EHDAA2:0001257|VHOG:0000513|EHDAA:912|ZFA:0001435	hp.json	lateral wall neural tube	http://purl.obolibrary.org/obo/UBERON_0005496		vertebrate_core
HP:0025157	biolink:PhenotypicFeature	Increased urinary sedoheptulose	An increased concentration of sedoheptulose in the urine. Sedoheptulose is a monosaccharide with seven carbon atoms and a ketone functional group.		hp.json		http://purl.obolibrary.org/obo/HP_0025157		
HP:0001187	biolink:PhenotypicFeature	Hyperextensibility of the finger joints	The ability of the finger joints to move beyond their normal range of motion.	UMLS:C1844577	hp.json	Hyperextensible finger|Hyperextensible digits|Hyperextensible fingers|Finger joint hyperextensibility	http://purl.obolibrary.org/obo/HP_0001187		
HP:0025158	biolink:PhenotypicFeature	Hyperautofluorescent retinal lesion	Increased amount of autofluorescence in the retina as ascertained by fundus autofluorescence imaging.		hp.json		http://purl.obolibrary.org/obo/HP_0025158		
HP:0001188	biolink:PhenotypicFeature	Hand clenching	An abnormal hand posture in which the hands are clenched to fists. All digits held completely flexed at the metacarpophalangeal and interphalangeal joints. In prenatal sonography of the fetal clenched hand, the index finger overlaps a clenched fist formed by the other digits. The proximal interphalangeal articulation of the index finger is flexed and ulnarly deviated, and the thumb is adducted.	UMLS:C0239815	hp.json	Clenched hand|Clenched hands|Hand clenching	http://purl.obolibrary.org/obo/HP_0001188		hposlim_core
HP:0025159	biolink:PhenotypicFeature	Hypoautofluorescent retinal lesion	Decreased amount of autofluorescence in the retina as ascertained by fundus autofluorescence imaging.		hp.json	Hypo-autofluorescent retinal lesion	http://purl.obolibrary.org/obo/HP_0025159		
UBERON:0005493	biolink:AnatomicalEntity	hyoid muscle	One of a group of muscles used in mastication and swallowing. These muscles are attached to the hyoid bone, which is suspended in the neck and forms the base of the tongue and larynx. The muscles are divided into suprahyoid (superior) or infrahyoid (inferior) groups relative to the bone[WP, generalized].	VHOG:0001494|NCIT:C32753|TAO:0000521|UMLS:C0448345|EFO:0003536|EHDAA2:0000794|ZFA:0000521	hp.json	hyoid muscles	http://purl.obolibrary.org/obo/UBERON_0005493		vertebrate_core|grouping_class|efo_slim
UBERON:0005492	biolink:AnatomicalEntity	hyaloid vessel	A blood vessel that is associated with the lens. In mammals, this is transient and normally nourishes the retina, immature lens and primary vitreous of the developing eye.	XAO:0004154|ZFA:0005046|TAO:0005046|VHOG:0000232|EHDAA:4735	hp.json	hyaloid blood vessels|hyaloid vascular system|hyaloid vasculature|hyaloid capillary system|hyaloid vessels	http://purl.obolibrary.org/obo/UBERON_0005492		vertebrate_core
UBERON:0005491	biolink:AnatomicalEntity	glossopharyngeal neural crest	Cranial neural crest which gives rise to the glossopharyngeal ganglion.	EHDAA:660|ZFA:0007066|EHDAA2:0000714|TAO:0007066	hp.json		http://purl.obolibrary.org/obo/UBERON_0005491		vertebrate_core
HP:0001181	biolink:PhenotypicFeature	Adducted thumb	In the resting position, the tip of the thumb is on, or near, the palm, close to the base of the fourth or fifth finger.	UMLS:C3554617	hp.json	Thumb-in-palm pattern|Thumb-in-palm deformity|Adducted thumbs|Inward turned thumb	http://purl.obolibrary.org/obo/HP_0001181		
HP:0001182	biolink:PhenotypicFeature	Tapered finger	The gradual reduction in girth of the finger from proximal to distal.	UMLS:C0426886|SNOMEDCT_US:249768009	hp.json	Tapered fingers|Tapering fingers|Tapered finger|Distally tapering fingers|Tapered fingertips	http://purl.obolibrary.org/obo/HP_0001182		hposlim_core
CHEBI:17002	biolink:ChemicalSubstance	cholesteryl ester	A sterol ester obtained by formal condensation of the carboxy group of any carboxylic acid with the 3-hydroxy group of cholesterol.	KEGG:C02530|PMID:2474544	hp.json	cholesteryl esters|Cholesterol ester|cholesterol esters|a cholesterol ester	http://purl.obolibrary.org/obo/CHEBI_17002		3_STAR
HP:0025150	biolink:PhenotypicFeature	Hypoganglionosis	Sparse and small myenteric ganglia		hp.json		http://purl.obolibrary.org/obo/HP_0025150		
HP:0025151	biolink:PhenotypicFeature	Ganglioneuromatosis	Hyperplastic submucosal and myenteric plexus containing an increased number of ganglion cells, glial cells and nerve fibers.		hp.json		http://purl.obolibrary.org/obo/HP_0025151		
HP:0001180	biolink:PhenotypicFeature	Hand oligodactyly	A developmental defect resulting in the presence of fewer than the normal number of fingers.	SNOMEDCT_US:71358006|UMLS:C0728895	hp.json	Hand has less than 5 fingers	http://purl.obolibrary.org/obo/HP_0001180		
HP:0025152	biolink:PhenotypicFeature	Poor visual behavior for age	Lack of visual responsiveness or decrease in visual capabilities suggesting a lack of visual responsiveness or decrease in visual capabilities in an infant or young child in which visual behavior fails to meet normal developmental milestones.		hp.json	Poor visual behaviour for age|Abnormal visual behavior for age|Abnormal visual behaviour for age	http://purl.obolibrary.org/obo/HP_0025152		
HP:0025153	biolink:PhenotypicFeature	Transient	Short-lived and not permanent. This term applies to a phenotypic abnormality that is temporary and of short duration.		hp.json		http://purl.obolibrary.org/obo/HP_0025153		
UBERON:0005499	biolink:AnatomicalEntity	rhombomere 1	Hindbrain segment or neuromere 1.	FMA:295790|EHDAA2:0001637|EFO:0003608|DHBA:12667|ZFA:0001031|DMBA:16915|TAO:0001031|EMAPA:16290	hp.json	r1	http://purl.obolibrary.org/obo/UBERON_0005499		vertebrate_core|pheno_slim|efo_slim
HP:0025154	biolink:PhenotypicFeature	Portosystemic collateral veins	Presence of biliary veins that serve as a collateral channel to the systemic circulation		hp.json	Collateral biliary circulation|Collateral biliary veins	http://purl.obolibrary.org/obo/HP_0025154		
HP:0025155	biolink:PhenotypicFeature	Abnormality of hepatobiliary system physiology	A functional anomaly of the hepatobiliary system		hp.json		http://purl.obolibrary.org/obo/HP_0025155		
UBERON:0005498	biolink:AnatomicalEntity	primitive heart tube	Multi-tissue structure that arises from the heart rudiment and will become the heart tube.	EHDAA:436|TAO:0000149|EHDAA:424|EHDAA2:0001512|FMA:321916|Wikipedia:Primitive_heart_tube|SCTID:361522004|ZFA:0000149|EMAPA:16215	hp.json	primitive heart tube|early primitive heart tube	http://purl.obolibrary.org/obo/UBERON_0005498		vertebrate_core
CHEBI:32612	biolink:ChemicalSubstance	isoleucinate		Gmelin:101585	hp.json	rel-(2R,3R)-2-amino-3-methylpentanoate|ile(-)|isoleucinate|isoleucine anion	http://purl.obolibrary.org/obo/CHEBI_32612		3_STAR
CHEBI:32613	biolink:ChemicalSubstance	isoleucinium		Gmelin:1651827	hp.json	H2ile(+)|rel-(1R,2R)-1-carboxy-2-methylbutan-1-aminium|isoleucinium|isoleucine cation	http://purl.obolibrary.org/obo/CHEBI_32613		3_STAR
UBERON:0005486	biolink:AnatomicalEntity	venous dural sinus	A venous channel found between layers of dura mater in the brain. Receives blood from internal and external veins of the brain, receive cerebrospinal fluid (CSF) from the subarachnoid space, and ultimately empty into the internal jugular vein.	NCIT:C102627|EMAPA:18634|EHDAA:6491|MA:0002113|EHDAA2:0002169|FMA:50762|VHOG:0001004	hp.json	dural venous sinus|dural vein|venous dural|dural sinus|cranial dural venous sinus|venous dural sinus|s. durae matris	http://purl.obolibrary.org/obo/UBERON_0005486		
HP:0025145	biolink:PhenotypicFeature	Rigors	Severe chills with violent shivering. A rigor is an episode of shaking or exaggerated shivering which can occur with a high fever.		hp.json	Rigours	http://purl.obolibrary.org/obo/HP_0025145		
GO:0043604	biolink:BiologicalProcess	amide biosynthetic process	The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.		hp.json		http://purl.obolibrary.org/obo/GO_0043604		
HP:0025146	biolink:PhenotypicFeature	Foveal degeneration	Deterioration of the tissue of the fovea, i.e.,the region of sharpest vision within the macula of the retina.		hp.json		http://purl.obolibrary.org/obo/HP_0025146		
UBERON:0005484	biolink:AnatomicalEntity	tricuspid valve leaflet	A valve leaflet that is part of a tricuspid valve.	MA:0003180|FMA:7237|EMAPA:18630|VHOG:0000821|RETIRED_EHDAA2:0002082	hp.json	leaflet of tricuspid valve|tricuspid valve leaflets|tricuspid valvular leaflet|tricuspid valve leaflet	http://purl.obolibrary.org/obo/UBERON_0005484		pheno_slim
HP:0025147	biolink:PhenotypicFeature	Beaten bronze macular sheen	A shiny appearance of the macula, which is often called a beaten bronze appearance.		hp.json	Beaten-bronze macular sheen|Beaten metal macular appearance|Beaten-bronze macular appearance	http://purl.obolibrary.org/obo/HP_0025147		
HP:0001199	biolink:PhenotypicFeature	Triphalangeal thumb	A thumb with three phalanges in a single, proximo-distal axis. Thus, this term applies if the thumb has an accessory phalanx, leading to a digit like appearance of the thumb.	MSH:C573898|UMLS:C0241397|SNOMEDCT_US:205308004	hp.json	Finger-like thumb|Accessory phalanx of the thumb|Triphalangy of thumb|Digitalized thumb|Triphalangeal thumbs	http://purl.obolibrary.org/obo/HP_0001199		hposlim_core
HP:0025148	biolink:PhenotypicFeature	Dark choroid	A fluorescein angiographic finding of absence of the normal background fluorescence (a dark choroid).		hp.json		http://purl.obolibrary.org/obo/HP_0025148		
UBERON:0005483	biolink:AnatomicalEntity	thymus lobe	Either of the two lateral lobes that constitute the thymus.	RETIRED_EHDAA2:0002021|FMA:71193	hp.json	lobe of thymus|lateral lobe of thymus	http://purl.obolibrary.org/obo/UBERON_0005483		human_reference_atlas
HP:0025149	biolink:PhenotypicFeature	Atrophic muscularis propria	Partial or complete wasting (loss) of muscularois propria tissue that was once present. The atrophy may involve a marked vacuolar degeneration of myocytes, loss of muscle fibers and some cases a highly characteristic honeycomb fibrosis.		hp.json	Autonomic visceral myopathy|Degenerative enteric myopathy	http://purl.obolibrary.org/obo/HP_0025149		
GO:0043603	biolink:BiologicalProcess	cellular amide metabolic process	The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.		hp.json	amide metabolism	http://purl.obolibrary.org/obo/GO_0043603		goslim_pir
HP:0001193	biolink:PhenotypicFeature	Ulnar deviation of the hand or of fingers of the hand		UMLS:C4048199	hp.json		http://purl.obolibrary.org/obo/HP_0001193		
HP:0001191	biolink:PhenotypicFeature	Abnormal carpal morphology	An abnormality affecting the carpal bones of the wrist (scaphoid, lunate, triquetral, pisiform, trapezium, trapezoid, capitate, hamate).	UMLS:C1840535	hp.json	Abnormal wrist bones|Abnormality of the carpal bones|Anomalous carpal bones|Carpal bone anomalies|Abnormal carpal bones	http://purl.obolibrary.org/obo/HP_0001191		hposlim_core
HP:0025140	biolink:PhenotypicFeature	Decreased serum estrone	A reduction below normal limits of the concentration of estrone in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0025140		
HP:0001196	biolink:PhenotypicFeature	Short umbilical cord	Decreased length of the umbilical cord.	SNOMEDCT_US:59795007|UMLS:C0266786	hp.json	Short umbilical cord	http://purl.obolibrary.org/obo/HP_0001196		
HP:0025141	biolink:PhenotypicFeature	Gingival calcification	Ectopic deposition of calcium salts found in the gingiva.		hp.json	Gingival calcifications	http://purl.obolibrary.org/obo/HP_0025141		
HP:0001197	biolink:PhenotypicFeature	Abnormality of prenatal development or birth	An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities.	UMLS:C4025797	hp.json	Abnormality of prenatal development or birth	http://purl.obolibrary.org/obo/HP_0001197		
HP:0025142	biolink:PhenotypicFeature	Constitutional symptom	A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.		hp.json		http://purl.obolibrary.org/obo/HP_0025142		
HP:0025143	biolink:PhenotypicFeature	Chills	A sudden sensation of feeling cold.		hp.json	Chills	http://purl.obolibrary.org/obo/HP_0025143		
CHEBI:78017	biolink:ChemicalSubstance	food propellant	A propellant that is used to expel foods from an aerosol container.		hp.json	food propellants	http://purl.obolibrary.org/obo/CHEBI_78017		3_STAR
HP:0001194	biolink:PhenotypicFeature	Abnormalities of placenta or umbilical cord	An abnormality of the placenta (the organ that connects the developing fetus to the uterine wall) or of the umbilical cord (the cord that connects the fetus to the placenta).	UMLS:C4025798	hp.json	Abnormalities of placenta or umbilical cord	http://purl.obolibrary.org/obo/HP_0001194		
HP:0001195	biolink:PhenotypicFeature	Single umbilical artery	Single umbilical artery (SUA) is the absence of one of the two umbilical arteries surrounding the fetal bladder and in the fetal umbilical cord.	MSH:D058529|SNOMEDCT_US:204470001|UMLS:C1384670	hp.json	Two-vessel cord|2 vessel cord|2 vessel umbilical cord|Only one artery in umbilical cord instead of two|Two vessel cord|Two vessel umbilical cord	http://purl.obolibrary.org/obo/HP_0001195		
HP:0025144	biolink:PhenotypicFeature	Shivering	Involuntary contraction or twitching of the muscles.		hp.json	Shuddering|Shivering	http://purl.obolibrary.org/obo/HP_0025144		
UBERON:0005487	biolink:AnatomicalEntity	vitelline vein	The paired veins that carry blood from the yolk sac back to the embryo.	NCIT:C34329|FMA:70305|XAO:0000376|SCTID:308832003|XAO:0004147|EMAPA:36021|Wikipedia:Vitelline_veins|SCTID:2730004|RETIRED_EHDAA2:0002209|UMLS:C0231091|VHOG:0000401	hp.json	vitelline veins|vascular vitelline network|vein of omphalomesenteric system|vena vitellina|omphalomesenteric vein|embryonic vitelline vein|vena vitellina	http://purl.obolibrary.org/obo/UBERON_0005487		vertebrate_core|pheno_slim
GO:0006665	biolink:BiologicalProcess	sphingolipid metabolic process	The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).		hp.json	sphingolipid metabolism	http://purl.obolibrary.org/obo/GO_0006665		
HP:0003749	biolink:PhenotypicFeature	Pelvic girdle muscle weakness	Weakness of the muscles of the pelvic girdle (also known as the hip girdle), that is, lack of strength of the muscles around the pelvis.	SNOMEDCT_US:249941003|UMLS:C0427064	hp.json	Pelvic girdle weakness|Hip-girdle muscle weakness|Hip girdle weakness|Hip girdle muscle weakness	http://purl.obolibrary.org/obo/HP_0003749		
GO:0006664	biolink:BiologicalProcess	glycolipid metabolic process	The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent.		hp.json	glycolipid metabolism	http://purl.obolibrary.org/obo/GO_0006664		
HP:0003741	biolink:PhenotypicFeature	Congenital muscular dystrophy		SNOMEDCT_US:240059009|UMLS:C0699743	hp.json	Muscular dystrophy, congenital	http://purl.obolibrary.org/obo/HP_0003741		
HP:0003740	biolink:PhenotypicFeature	Myotonia with warm-up phenomenon	Myotonia that occurs after a period of rest and decreases with continuing exercise.	UMLS:C4025575	hp.json		http://purl.obolibrary.org/obo/HP_0003740		
PATO:0001178	biolink:NamedThing	resistant to	A resistance quality inhering in a bearer by virtue of the bearer's resistance to a stimulus.		hp.json	resistant	http://purl.obolibrary.org/obo/PATO_0001178		disposition_slim|relational_slim|value_slim
HP:0003745	biolink:PhenotypicFeature	Sporadic	Cases of the disease in question occur without a previous family history, i.e., as isolated cases without being transmitted from a parent and without other siblings being affected.	UMLS:C1853237	hp.json	No previous family history|Isolated cases	http://purl.obolibrary.org/obo/HP_0003745		
HP:0003744	biolink:PhenotypicFeature	Genetic anticipation with paternal anticipation bias	A type of genetic anticipation observed predominantly upon transmission from affected males.	UMLS:C1834002|UMLS:C4025574	hp.json	Paternal anticipation bias	http://purl.obolibrary.org/obo/HP_0003744		
HP:0003743	biolink:PhenotypicFeature	Genetic anticipation	A type of autosomal dominant inheritance involving a gene that exhibits anticipation, the increase in severity and/or an earlier age of onset in subsequent generations.	UMLS:C0600498|MSH:D020132	hp.json	Autosomal dominant with genetic anticipation	http://purl.obolibrary.org/obo/HP_0003743		
CHEBI:30089	biolink:ChemicalSubstance	acetate	A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid.	PMID:22211106|UM-BBD_compID:c0050|Wikipedia:Acetate|PMID:17190852|KEGG:C00033|PDBeChem:ACT|CAS:71-50-1|Beilstein:1901470|Gmelin:1379|Reaxys:1901470|PMID:22371380|MetaCyc:ACET|DrugBank:DB03166|CAS:71-50-1	hp.json	Azetat|ethanoate|acetate|acetate|MeCO2 anion|CH3-COO(-)|acetic acid, ion(1-)|Ethanoat|ACETATE ION	http://purl.obolibrary.org/obo/CHEBI_30089		3_STAR
PATO:0001171	biolink:NamedThing	elastic	An elasticity quality inhering in a bearer by virtue of the bearer's ability to recover its size and shape after deformation in any way.		hp.json		http://purl.obolibrary.org/obo/PATO_0001171		disposition_slim|value_slim|mpath_slim
HP:0003759	biolink:PhenotypicFeature	Hypoplasia of lymphatic vessels	Congenital underdevelopment of lymph vessels.	UMLS:C4025570	hp.json	Underdeveloped lymphatic vessels	http://purl.obolibrary.org/obo/HP_0003759		
GO:0006672	biolink:BiologicalProcess	ceramide metabolic process	The chemical reactions and pathways involving ceramides, any N-acylated sphingoid.		hp.json	ceramide metabolism	http://purl.obolibrary.org/obo/GO_0006672		
HP:0003758	biolink:PhenotypicFeature	Reduced subcutaneous adipose tissue	A reduced amount of fat tissue in the lowest layer of the integument. This feature can be appreciated by a reduced skinfold thickness.	UMLS:C1857657|UMLS:C0424631|SNOMEDCT_US:248316006	hp.json	Reduced fat tissue below the skin|Reduced subcutaneous fat|Decreased subcutaneous adipose tissue|Scanty adipose tissue|Decreased subcutaneous fat	http://purl.obolibrary.org/obo/HP_0003758		
HP:0003752	biolink:PhenotypicFeature	Episodic flaccid weakness	Recurrent episodes of muscle flaccidity, a type of paralysis in which a muscle becomes soft and yields to passive stretching.	UMLS:C4025572	hp.json		http://purl.obolibrary.org/obo/HP_0003752		
HP:0003750	biolink:PhenotypicFeature	Increased muscle fatiguability	An abnormal, increased fatiguability of the musculature.	UMLS:C0242979|UMLS:C4025573|MSH:D018763|SNOMEDCT_US:80449002	hp.json	Muscle fatigue	http://purl.obolibrary.org/obo/HP_0003750		
HP:0003756	biolink:PhenotypicFeature	Skeletal myopathy		SNOMEDCT_US:75047002|UMLS:C1533847	hp.json		http://purl.obolibrary.org/obo/HP_0003756		
HP:0003755	biolink:PhenotypicFeature	Type 1 fibers relatively smaller than type 2 fibers	The presence of abnormal muscle fiber size such that type 1 fibers are smaller than type 2 fibers.	UMLS:C4025571	hp.json	Type 1 fibres relatively smaller than type 2 fibres	http://purl.obolibrary.org/obo/HP_0003755		
GO:0006643	biolink:BiologicalProcess	membrane lipid metabolic process	The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.		hp.json	membrane lipid metabolism	http://purl.obolibrary.org/obo/GO_0006643		
HP:0003725	biolink:PhenotypicFeature	Firm muscles		UMLS:C1850656	hp.json		http://purl.obolibrary.org/obo/HP_0003725		
HP:0003729	biolink:PhenotypicFeature	Enteroviral dermatomyositis syndrome		UMLS:C3806660	hp.json		http://purl.obolibrary.org/obo/HP_0003729		
HP:0003720	biolink:PhenotypicFeature	Generalized muscle hypertrophy	Hypertrophy (increase in size) of muscle tissue in a generalized (not localized) distribution.	UMLS:C3805639	hp.json	Generalized increase in muscle cell size|Generalised increase in muscle cell size|Generalised muscle hypertrophy	http://purl.obolibrary.org/obo/HP_0003720		
PATO:0001195	biolink:NamedThing	proximal to	A spatial quality inhering in a bearer by virtue of the bearer's being located more centrally than another entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001195		relational_slim|value_slim|mpath_slim
HP:0003724	biolink:PhenotypicFeature	Shoulder girdle muscle atrophy	Amyotrophy affecting the muscles of the shoulder girdle.	UMLS:C1847766	hp.json	Shoulder girdle muscle wasting|Shoulder girdle atrophy|Shoulder-girdle muscle atrophy	http://purl.obolibrary.org/obo/HP_0003724		
HP:0003722	biolink:PhenotypicFeature	Neck flexor weakness	Weakness of the muscles involved in neck flexion (sternocleidomastoid, longus capitus, longus colli, and scalenus anterior).	UMLS:C1843637	hp.json	Neck flexor muscle weakness|Neck flexion weakness	http://purl.obolibrary.org/obo/HP_0003722		
PATO:0001190	biolink:NamedThing	juvenile	A maturity quality inhering in a bearer by virtue the bearer's being not fully grown or developed.		hp.json		http://purl.obolibrary.org/obo/PATO_0001190		mpath_slim|value_slim
PR:O15353	biolink:Protein	forkhead box protein N1 (human)	A forkhead box protein N1 that is encoded in the genome of human.	UniProtKB:O15353	hp.json	RONU|FOXN1|hFOXN1|WHN|winged-helix transcription factor nude (human)	http://purl.obolibrary.org/obo/PR_O15353		
HP:0003739	biolink:PhenotypicFeature	Myoclonic spasms		UMLS:C3806442	hp.json		http://purl.obolibrary.org/obo/HP_0003739		
HP:0003738	biolink:PhenotypicFeature	Exercise-induced myalgia	The occurrence of an unusually high amount of muscle pain following exercise.	UMLS:C1850830	hp.json	Muscle pain with exercise|Muscle pain, exercise-induced|Muscle pain on exercise|Exercise-induced muscle pain	http://purl.obolibrary.org/obo/HP_0003738		
HP:0003737	biolink:PhenotypicFeature	Mitochondrial myopathy	A type of myopathy associated with mitochondrial disease and characterized by findings on biopsy such as ragged red muscle fibers.	UMLS:C0162670|MSH:D017240|SNOMEDCT_US:16851005	hp.json		http://purl.obolibrary.org/obo/HP_0003737		
HP:0003736	biolink:PhenotypicFeature	Autophagic vacuoles	The lysosomal-vacuolar pathway has a role in the controlled intracellular digestion of macromolecules such as protein complexes and organelles. This feature refers to the presence of an abnormally increased number of autophagic vacuoles in muscle tissue.	UMLS:C0544966	hp.json		http://purl.obolibrary.org/obo/HP_0003736		
HP:0003731	biolink:PhenotypicFeature	Quadriceps muscle weakness	Weakness of the quadriceps muscle (that is, of the muscle fasciculus of quadriceps femoris).	SNOMEDCT_US:300948004|UMLS:C0577655	hp.json	Quadriceps weakness	http://purl.obolibrary.org/obo/HP_0003731		
HP:0003730	biolink:PhenotypicFeature	EMG: myotonic runs	Spontaneous, repetitive electrical activity demonstrated by electromyography (EMG).	UMLS:C4025576|UMLS:C4020837	hp.json	EMG: spontaneous, repetitive electrical activity	http://purl.obolibrary.org/obo/HP_0003730		
HP:0003733	biolink:PhenotypicFeature	Thigh hypertrophy	Muscle hypertrophy affecting the thighs.	UMLS:C1846674	hp.json	Increased thigh size	http://purl.obolibrary.org/obo/HP_0003733		
HP:0001129	biolink:PhenotypicFeature	Large central visual field defect		UMLS:C4025800	hp.json	Large central loss of field of vision	http://purl.obolibrary.org/obo/HP_0001129		
HGNC:4268	biolink:Gene	CBLIF (human)	A protein coding gene CBLIF in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4268		
CHEBI:29057	biolink:ChemicalSubstance	keratan			hp.json		http://purl.obolibrary.org/obo/CHEBI_29057		1_STAR
HP:0001123	biolink:PhenotypicFeature	Visual field defect		SNOMEDCT_US:12184005|UMLS:C3887875	hp.json	Visual field defects|Partial loss of field of vision	http://purl.obolibrary.org/obo/HP_0001123		
UBERON:0005430	biolink:AnatomicalEntity	ansa cervicalis	A loop of nerves that are part of the cervical plexus that lies superficial to the internal jugular vein in the carotid sheath. Branches from the ansa cervicalis innervate three of the four infrahyoid muscles, including the sternohyoid muscle, the sternothyroid muscle, and the omohyoid muscle.	FMA:55142|BAMS:ancer|EHDAA:6669|EHDAA2:0000124	hp.json	ansa cervicalis|ansa hypoglossi	http://purl.obolibrary.org/obo/UBERON_0005430		
HP:0003785	biolink:PhenotypicFeature	Decreased CSF homovanillic acid concentration	Decreased concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine.	UMLS:C4280803	hp.json		http://purl.obolibrary.org/obo/HP_0003785		
HP:0003784	biolink:PhenotypicFeature	Type 1 collagen overmodification		UMLS:C1970463	hp.json		http://purl.obolibrary.org/obo/HP_0003784		
HP:0001122	biolink:PhenotypicFeature	obsolete Aplasia/Hypoplasia of the choroid			hp.json		http://purl.obolibrary.org/obo/HP_0001122		
HP:0003783	biolink:PhenotypicFeature	obsolete Externally rotated/abducted legs			hp.json		http://purl.obolibrary.org/obo/HP_0003783		
CHEBI:4439	biolink:ChemicalSubstance	dermatan	A mucopolysaccharide consisting of repeating beta-(1->4)-linked L-iduronyl-(alpha1->3)-N-acetyl-D-galactosamine units.	KEGG:C01490	hp.json	Dermatan|Dermatan L-iduronate	http://purl.obolibrary.org/obo/CHEBI_4439		3_STAR
HP:0001128	biolink:PhenotypicFeature	Trichiasis	Inversion and rubbing of the eyelashes against the globe of the eye.	SNOMEDCT_US:60332004|MSH:D058457|UMLS:C0221259	hp.json	Introversion of eyelashes|Trichiasis of eyelid eyelashes|Ingrown eyelashes	http://purl.obolibrary.org/obo/HP_0001128		
HP:0003789	biolink:PhenotypicFeature	Minicore myopathy	Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in muscle fibers.	UMLS:C1850674|MSH:C564969	hp.json		http://purl.obolibrary.org/obo/HP_0003789		
HP:0001125	biolink:PhenotypicFeature	Transient unilateral blurring of vision	Transient blurring of vision associated with the aura phase of migraine.	UMLS:C1865332	hp.json	Transient unilateral blurred vision|Hemianopic blurring|Hemianoptic blurring of vision	http://purl.obolibrary.org/obo/HP_0001125		
HP:0003787	biolink:PhenotypicFeature	Type 1 and type 2 muscle fiber minicore regions	Multiple small zones of sarcomeric disorganization and lack of oxidative activity (known as minicores) in type 1 and type 2 muscle fibers.	UMLS:C4025568	hp.json	Type 1 and type 2 muscle fibre minicore regions	http://purl.obolibrary.org/obo/HP_0003787		
HP:0001126	biolink:PhenotypicFeature	Cryptophthalmos	Cryptophthalmos is a condition of total absence of eyelids and the skin of forehead is continuous with that of cheek, in which the eyeball is completely concealed by the skin, which is stretched over the orbital cavity.	SNOMEDCT_US:400951005|UMLS:C0311249	hp.json		http://purl.obolibrary.org/obo/HP_0001126		hposlim_core
UBERON:0005438	biolink:AnatomicalEntity	coronary sinus	The short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occurring between the inferior vena cava and the atrioventricular orifice.	FMA:4706|EHDAA2:0000320|EHDAA:9884|MESH:D054326|UMLS:C0456944|EMAPA:37836|NCIT:C32378	hp.json	sinus coronarius|sinus coronarius	http://purl.obolibrary.org/obo/UBERON_0005438		pheno_slim|human_reference_atlas
UBERON:0005436	biolink:AnatomicalEntity	common hepatic artery	In anatomy, the common hepatic artery is a short blood vessel that supplies oxygenated blood to the liver, pylorus (a part of the stomach), duodenum (a part of the small intestine) and pancreas. It arises from the celiac artery and has the following branches:.	EMAPA:37206|MA:0003094|EHDAA2:0000308|EHDAA:8570|galen:CommonHepaticArtery|FMA:14771	hp.json	common hepatic|arteria hepatica communis	http://purl.obolibrary.org/obo/UBERON_0005436		human_reference_atlas
HP:0003782	biolink:PhenotypicFeature	Eunuchoid habitus	A body habitus that is tall, slim and underweight, with long legs and long arms (i.e., arm span exceeds height by 5 cm or more).	UMLS:C4025569	hp.json		http://purl.obolibrary.org/obo/HP_0003782		
HP:0003781	biolink:PhenotypicFeature	Excessive salivation	Excessive production of saliva.	SNOMEDCT_US:53827007|SNOMEDCT_US:275295002|SNOMEDCT_US:62718007|UMLS:C0037036|UMLS:C0013132|MSH:D012798	hp.json	Watery mouth|Excessive salivation|Mouth watering|Hypersalivation|Oversalivation|Excessive production of saliva|Ptyalism	http://purl.obolibrary.org/obo/HP_0003781		
UBERON:0005434	biolink:AnatomicalEntity	cervical region		FMA:24219|SCTID:123958008	hp.json	region of neck|neck subdivision|cervical region|subdivision of neck	http://purl.obolibrary.org/obo/UBERON_0005434		
HP:0001120	biolink:PhenotypicFeature	Abnormality of corneal size	Any abnormality of the size or morphology of the cornea.	UMLS:C4025802	hp.json		http://purl.obolibrary.org/obo/HP_0001120		
GO:0006629	biolink:BiologicalProcess	lipid metabolic process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.	Wikipedia:Lipid_metabolism	hp.json	lipid metabolism	http://purl.obolibrary.org/obo/GO_0006629		goslim_plant|goslim_pir|goslim_pombe|goslim_drosophila|goslim_chembl|goslim_aspergillus|goslim_mouse|goslim_metagenomics|goslim_yeast|goslim_candida|goslim_agr|goslim_generic|prokaryote_subset
UBERON:0005432	biolink:AnatomicalEntity	aortic sac	The dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates.	EHDAA2:0004145|FMA:71008|RETIRED_EHDAA2:0000133|SCTID:361527005|EMAPA:36461|EHDAA:9826	hp.json	saccus aorticus	http://purl.obolibrary.org/obo/UBERON_0005432		pheno_slim
CHEBI:17062	biolink:ChemicalSubstance	primary aliphatic amine		KEGG:C00375	hp.json	RCH2NH2|RCH2NH2|primary aliphatic amines	http://purl.obolibrary.org/obo/CHEBI_17062		3_STAR
UBERON:0005419	biolink:AnatomicalEntity	pectoral appendage bud	A limb bud that develops into a forelimb or pectoral fin.	VHOG_RETIRED:0001259|ZFA:0000141|TAO:0000141|VHOG:0001754|EFO:0003430	hp.json	pectoral fin bud|pectoral fin buds|forelimb - pectoral fin bud	http://purl.obolibrary.org/obo/UBERON_0005419		efo_slim
UBERON:0005418	biolink:AnatomicalEntity	hindlimb bud	A limb bud that develops into a hindlimb.	EHDAA:2358|XAO:0003066|RETIRED_EHDAA2:0003197|MIAA:0000256|EMAPA:16779|AAO:0010382	hp.json	leg bud|hind limb bud|posterior limb bud|limb bud - hindlimb	http://purl.obolibrary.org/obo/UBERON_0005418		pheno_slim
GO:0006631	biolink:BiologicalProcess	fatty acid metabolic process	The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.	Wikipedia:Fatty_acid_metabolism	hp.json	fatty acid metabolism	http://purl.obolibrary.org/obo/GO_0006631		
CHEBI:29067	biolink:ChemicalSubstance	carboxylic acid anion	The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated.		hp.json	carboxylic anions|carboxylic acid anions|a carboxylate	http://purl.obolibrary.org/obo/CHEBI_29067		3_STAR
UBERON:0005420	biolink:AnatomicalEntity	pelvic appendage bud	A limb bud that develops into a hindlimb or pelvic fin.	ZFA:0001384|EFO:0003469|TAO:0001384|VHOG:0001260	hp.json	hindlimb/pelvic fin bud|pelvic fin buds|pelvic fin bud	http://purl.obolibrary.org/obo/UBERON_0005420		efo_slim
HP:0001134	biolink:PhenotypicFeature	Anterior polar cataract	A polar cataract that affects the anterior pole of the lens.	MSH:C538282|UMLS:C1855179	hp.json	Polar cataract, anterior	http://purl.obolibrary.org/obo/HP_0001134		
HP:0003797	biolink:PhenotypicFeature	Limb-girdle muscle atrophy	Muscular atrophy affecting the muscles of the limb girdle.	UMLS:C1404521|UMLS:C1842552	hp.json	Limb-girdle myopathy|Wasting of limb-girdle muscle	http://purl.obolibrary.org/obo/HP_0003797		
HP:0003796	biolink:PhenotypicFeature	Irregular iliac crest	Irregularity of the iliac crest, which is the superior border of the wing of the ilium.	UMLS:C1855180	hp.json		http://purl.obolibrary.org/obo/HP_0003796		
HP:0001135	biolink:PhenotypicFeature	Chorioretinal dystrophy		UMLS:C1857627	hp.json		http://purl.obolibrary.org/obo/HP_0001135		
HP:0003795	biolink:PhenotypicFeature	Short middle phalanx of toe	Developmental hypoplasia (shortening) of middle phalanx of toe.	UMLS:C4021723	hp.json	Short middle phalanges of toes|Short middle bones (feet)	http://purl.obolibrary.org/obo/HP_0003795		
HP:0001132	biolink:PhenotypicFeature	Lens subluxation	Partial dislocation of the lens of the eye.	UMLS:C0023316|MSH:D007906|SNOMEDCT_US:65814009	hp.json	Partially dislocated lens	http://purl.obolibrary.org/obo/HP_0001132		
HP:0001133	biolink:PhenotypicFeature	Constriction of peripheral visual field	An absolute or relative decrease in retinal sensitivity extending from edge (periphery) of the visual field in a concentric pattern. The visual field is the area that is perceived simultaneously by a fixating eye.	UMLS:C0235095|SNOMEDCT_US:1151008|SNOMEDCT_US:267628004	hp.json	Constricted visual field|Limited peripheral vision|Concentric narrowing of visual field|Reduced peripheral vision|Constricted visual fields|Visual field constriction	http://purl.obolibrary.org/obo/HP_0001133		
HP:0001138	biolink:PhenotypicFeature	Optic neuropathy		SNOMEDCT_US:82108004|UMLS:C3887709	hp.json	Damaged optic nerve	http://purl.obolibrary.org/obo/HP_0001138		
HP:0001139	biolink:PhenotypicFeature	Choroideremia		SNOMEDCT_US:75241009|MSH:D015794|UMLS:C0008525	hp.json		http://purl.obolibrary.org/obo/HP_0001139		
HP:0003799	biolink:PhenotypicFeature	Marked delay in bone age		UMLS:C1868549	hp.json	Markedly retarded bone age|Marked retardation in skeletal maturation|Marked delay in bone age	http://purl.obolibrary.org/obo/HP_0003799		
HP:0001136	biolink:PhenotypicFeature	Retinal arteriolar tortuosity	The presence of an increased number of twists and turns of the retinal arterioles.	UMLS:C1843517	hp.json	Tortuous retinal arterioles	http://purl.obolibrary.org/obo/HP_0001136		
HP:0001137	biolink:PhenotypicFeature	Alternating esotropia	Esotropia in which either eye may be used for fixation.	SNOMEDCT_US:39837002|UMLS:C0152205	hp.json	Alternating cross eyes	http://purl.obolibrary.org/obo/HP_0001137		
NCBITaxon:716545	biolink:OrganismalEntity	saccharomyceta		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_716545		
HP:0003798	biolink:PhenotypicFeature	Nemaline bodies	Nemaline rods are abnormal bodies that can occur in skeletal muscle fibers. The rods can be observed on histological analysis of muscle biopsy tissue or upon electron microscopy, where they appear either as extensions of sarcomeric Z-lines, in random array without obvious attachment to Z-lines (often in areas devoid of sarcomeres) or in large clusters localized at the sarcolemma or intermyofibrillar spaces.	UMLS:C3808039	hp.json	Nemaline rods	http://purl.obolibrary.org/obo/HP_0003798		
UBERON:0005428	biolink:AnatomicalEntity	vagal neural crest	Vagal neural crest is adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives[ZFA].	ZFA:0000818|VHOG:0001208|EHDAA2:0002156|TAO:0000818|XAO:0004191|EHDAA:669	hp.json	enteric neural crest|post-otic neural crest|VNC	http://purl.obolibrary.org/obo/UBERON_0005428		vertebrate_core
UBERON:0005427	biolink:AnatomicalEntity	corneal primordium	Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea.	TAO:0002188|ZFA:0001688	hp.json		http://purl.obolibrary.org/obo/UBERON_0005427		
UBERON:0005426	biolink:AnatomicalEntity	lens vesicle	Portion of tissue that gives rise to the lens.	EHDAA2:0000983|EMAPA:17163|ZFA:0001679|SCTID:361510002|EHDAA:4737|TAO:0002205|VHOG:0001163	hp.json	immature lens|presumptive lens|hollow lens vesicle|solid lens vesicle|lens mass	http://purl.obolibrary.org/obo/UBERON_0005426		pheno_slim|vertebrate_core
UBERON:0005425	biolink:AnatomicalEntity	presumptive neural retina	Portion of tissue that is the inner layer of the optic cup and will become the neural retina.	VHOG:0000490|ZFA:0001071|TAO:0001071|EMAPA:16675|EHDAA2:0001304	hp.json	future NR|future retinal neural layer|presumptive retina|future neural layer|future neural epithelium|presumptive retinas|optic cup inner layer|future neural retina|inner layer optic cup	http://purl.obolibrary.org/obo/UBERON_0005425		vertebrate_core
UBERON:0005424	biolink:AnatomicalEntity	presumptive retinal pigmented epithelium	Portion of tissue that is the outer layer of the optic cup and will become the retinal pigmented epithelium.	ZFA:0000064|TAO:0000064|EMAPA:16677|EHDAA2:0001306|VHOG:0000492	hp.json	future pigmented layer|future RPE|optic cup outer layer|future retinal pigmented epithelium|presumptive pigmented epithelium|future pigmented retinal epithelium|future PRE|presumptive pigmented epithelia|outer layer optic cup	http://purl.obolibrary.org/obo/UBERON_0005424		vertebrate_core
HP:0001131	biolink:PhenotypicFeature	Corneal dystrophy	The term corneal dystrophy embraces a heterogenous group of bilateral genetically determined non-inflammatory corneal diseases that are restricted to the cornea.	SNOMEDCT_US:5587004|UMLS:C0010036	hp.json		http://purl.obolibrary.org/obo/HP_0001131		hposlim_core
UBERON:0005423	biolink:AnatomicalEntity	developing anatomical structure		FBbt:00007006|FMA:292313|MIAA:0000019|EHDAA2:0003125|AEO:0000125|CALOHA:TS-2122	hp.json	developmental structure|developing structure|developmental tissue	http://purl.obolibrary.org/obo/UBERON_0005423		
HP:0003791	biolink:PhenotypicFeature	Deposits immunoreactive to beta-amyloid protein		UMLS:C1853934	hp.json		http://purl.obolibrary.org/obo/HP_0003791		
CHEBI:17053	biolink:ChemicalSubstance	L-aspartic acid	The L-enantiomer of aspartic acid.	YMDB:YMDB00896|DrugBank:DB00128|MetaCyc:L-ASPARTATE|ECMDB:ECMDB00191|PMID:21359215|PDBeChem:ASP|Gmelin:3333|PMID:11568288|KEGG:C00049|KNApSAcK:C00001342|Reaxys:1723530|Beilstein:1723530|CAS:56-84-8|PMID:22770225|HMDB:HMDB0000191|KEGG:D00013|Drug_Central:1550|CAS:56-84-8|CAS:56-84-8	hp.json	D|(S)-2-aminobutanedioic acid|ASPARTIC ACID|2-Aminosuccinic acid|L-aspartic acid|Asp|L-Asparaginsaeure|L-Aspartic acid|(2S)-2-aminobutanedioic acid|(S)-2-aminosuccinic acid	http://purl.obolibrary.org/obo/CHEBI_17053		3_STAR
UBERON:0005422	biolink:AnatomicalEntity	pelvic appendage apical ectodermal ridge	An apical ectodermal ridge that is part of a pelvic appendage bud.	ZFA:0001385|TAO:0001385|EFO:0003681|EHDAA2:0003194|VHOG:0001066|EMAPA:16892	hp.json	apical ectodermal ridge hind limb|apical ectodermal ridge hindlimb|AER hindlimb|leg AER|apical ectodermal ridge pelvic fin bud|lower lmb bud apical ectodermal ridge	http://purl.obolibrary.org/obo/UBERON_0005422		efo_slim|vertebrate_core
UBERON:0005421	biolink:AnatomicalEntity	pectoral appendage apical ectodermal ridge	An apical ectodermal ridge that is part of a pectoral appendage bud.	ZFA:0000085|TAO:0000085|EFO:0003487|EMAPA:16778|TAO:0000736|VHOG:0001064|EHDAA2:0000138	hp.json	AER forelimb|apical fold pectoral fin|apical ectodermal ridge pectoral fin bud|aer pectoral fin|wing apical ectodermal ridge|upper limb bud apical ectodermal ridge|apical ectodermal ridge forelimb|apical ectodermal ridge pectoral fin|wing AER	http://purl.obolibrary.org/obo/UBERON_0005421		efo_slim|vertebrate_core
UBERON:0005409	biolink:AnatomicalEntity	alimentary part of gastrointestinal system	The part of the digestive system that excludes the hepatobiliary system.	EMAPA:16246|EHDAA:514|MA:0000323|MESH:D041981|UMLS:C0012240|NCIT:C12378|SCTID:373871007|CALOHA:TS-0407|GAID:294|EHDAA2:0000110|EV:0100056|FMA:71132|galen:GastrointestinalTract|BTO:0000058|MESH:A03.492|VHOG:0000412	hp.json	alimentary system|alimentary tract|gastroenterological system|GI tract|gastro-intestinal system|gastrointestinal (GI) tract|gastrointestinal system|gastrointestinal tract	http://purl.obolibrary.org/obo/UBERON_0005409		pheno_slim
UBERON:0005408	biolink:AnatomicalEntity	circumventricular organ	Any of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow.	MESH:D066280|MA:0002942|EMAPA:35243|FMA:84081|NLXANAT:20090312	hp.json	CVO|circumventricular organ|circumventricular organ of neuraxis	http://purl.obolibrary.org/obo/UBERON_0005408		pheno_slim
UBERON:0005407	biolink:AnatomicalEntity	sublingual ganglion	The small parasympathetic ganglion found anterior to the submandibular gland that provides postsynaptic fibers to the sublingual gland.	FMA:77591|MA:0002982|EHDAA:10101|EHDAA2:0001938	hp.json		http://purl.obolibrary.org/obo/UBERON_0005407		pheno_slim
GO:0006600	biolink:BiologicalProcess	creatine metabolic process	The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle.		hp.json	creatine metabolism	http://purl.obolibrary.org/obo/GO_0006600		
HP:0001107	biolink:PhenotypicFeature	Ocular albinism	An abnormal reduction in the amount of pigmentation (reduced or absent) of the iris and retina.	UMLS:C0078917|MSH:D016117|SNOMEDCT_US:26399002	hp.json	Albinism, Ocular|Absent pigmentation in the eye	http://purl.obolibrary.org/obo/HP_0001107		
PATO:0001159	biolink:NamedThing	concentrated	A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration.		hp.json		http://purl.obolibrary.org/obo/PATO_0001159		relational_slim|value_slim
HP:0003764	biolink:PhenotypicFeature	Nevus	A nevus is a type of hamartoma that is a circumscribed stable malformation of the skin.	SNOMEDCT_US:21119008|SNOMEDCT_US:51697005|SNOMEDCT_US:400096001|MSH:D009508|MSH:D009506|UMLS:C0027962|UMLS:C0027960	hp.json	Nevi|Mole|Naevus|Naevi	http://purl.obolibrary.org/obo/HP_0003764		
PATO:0001152	biolink:NamedThing	susceptible toward	A quality inhering in a bearer by virtue of the bearer's having susceptibilty toward an external stimulus.		hp.json	susceptible	http://purl.obolibrary.org/obo/PATO_0001152		disposition_slim|relational_slim|value_slim
HP:0001101	biolink:PhenotypicFeature	Iritis	Inflammation of the iris.	UMLS:C0022081|MSH:D007500|SNOMEDCT_US:65074000	hp.json	Inflammation of iris	http://purl.obolibrary.org/obo/HP_0001101		
HP:0001102	biolink:PhenotypicFeature	Angioid streaks of the fundus	Irregular lines in the deep retina that are typically configured in a radiating fashion and emanate from the optic disc. Angioid streaks are crack-like dehiscences in abnormally thickened and calcified Bruch's membrane, resulting in atrophy of the overlying retinal pigment epithelium. They may be associated with a number of endocrine, metabolic, and connective tissue abnormalities but are frequently idiopathic.	MSH:D000793|UMLS:C0002982	hp.json	Laquer cracks of the retina|Knapp streaks|Angioid streaks of the retina|Angioid streaks|Angioid streaks, retina	http://purl.obolibrary.org/obo/HP_0001102		
HP:0003763	biolink:PhenotypicFeature	Bruxism	Bruxism is characterized by the grinding of the teeth including the clenching of the jaw and typically occur during sleep, but also can occcur while the affected individual is awake.	MSH:D002012|SNOMEDCT_US:90207007|UMLS:C0006325|SNOMEDCT_US:191983006	hp.json	Teeth grinding	http://purl.obolibrary.org/obo/HP_0003763		
HP:0003762	biolink:PhenotypicFeature	Uterus didelphys	A malformation of the uterus in which the uterus is present as a paired organ as a result of the failure of fusion of the mullerian ducts during embryogenesis.	UMLS:C0266393|SNOMEDCT_US:22504001|UMLS:C0152240|SNOMEDCT_US:15545001	hp.json	Double uterus	http://purl.obolibrary.org/obo/HP_0003762		
HP:0001100	biolink:PhenotypicFeature	Heterochromia iridis	Heterochromia iridis is a difference in the color of the iris in the two eyes.	UMLS:C0423318|SNOMEDCT_US:247033008|MSH:C538115	hp.json	Different coloured eyes|Different colored eyes|Heterochromia irides	http://purl.obolibrary.org/obo/HP_0001100		hposlim_core
HP:0003761	biolink:PhenotypicFeature	Calcinosis	Formation of calcium deposits in any soft tissue.	MSH:D002114|SNOMEDCT_US:6595006|UMLS:C0006663	hp.json	Calcium buildup in soft tissues of body	http://purl.obolibrary.org/obo/HP_0003761		
HP:0001105	biolink:PhenotypicFeature	Retinal atrophy	Well-demarcated area(s) of partial or complete depigmentation in the fundus, reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss.	UMLS:C0521694|SNOMEDCT_US:95695004|SNOMEDCT_US:405722004|UMLS:C0035304|MSH:D012162	hp.json		http://purl.obolibrary.org/obo/HP_0001105		
HP:0003768	biolink:PhenotypicFeature	Periodic paralysis	Episodes of muscle weakness.	SNOMEDCT_US:198030008|UMLS:C1279412	hp.json	Episodic paralysis	http://purl.obolibrary.org/obo/HP_0003768		
HP:0001106	biolink:PhenotypicFeature	Periorbital hyperpigmentation	Increased pigmentation of the skin in the region surrounding the orbit of the eye.	UMLS:C1844606	hp.json	Dark circles under the eyes|Idiopathic cutaneous hyperchromia at the orbital region|Dark circles around the eyes|Pigmentation around the eyes|Periorbital melanosis|Darkening around the eyes|Infraorbital pigmentation	http://purl.obolibrary.org/obo/HP_0001106		
PATO:0001154	biolink:NamedThing	elongated	A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width.		hp.json		http://purl.obolibrary.org/obo/PATO_0001154		value_slim
HP:0001103	biolink:PhenotypicFeature	Abnormal macular morphology	A structural abnormality of the macula lutea, which is an oval-shaped highly pigmented yellow spot near the center of the retina.	UMLS:C0730362|SNOMEDCT_US:312999006	hp.json	Macula abnormality|Macular abnormality|Abnormality of the macula	http://purl.obolibrary.org/obo/HP_0001103		hposlim_core
HP:0001104	biolink:PhenotypicFeature	Macular hypoplasia	Underdevelopment of the macula lutea.	UMLS:C1849412	hp.json		http://purl.obolibrary.org/obo/HP_0001104		hposlim_core
HP:0003765	biolink:PhenotypicFeature	Psoriasiform dermatitis	A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales).	SNOMEDCT_US:9014002|MSH:D011565|UMLS:C0033860	hp.json	Psoriasis	http://purl.obolibrary.org/obo/HP_0003765		
UBERON:0005417	biolink:AnatomicalEntity	forelimb bud	A limb bud that develops into a forelimb.	EHDAA:1699|RETIRED_EHDAA2:0003198|BTO:0001645|XAO:0003065|EMAPA:16406|FMA:296782|AAO:0010381|MIAA:0000065	hp.json	limb bud - forelimb|anterior limb bud|upper limb bud|arm bud|wing bud	http://purl.obolibrary.org/obo/UBERON_0005417		pheno_slim
UBERON:0005413	biolink:AnatomicalEntity	spinocerebellar tract	This tract conveys interoceptive, proprioceptive, and exteroceptive information from the body's internal organs, and from the trunk, extremities, and neck region to the Cerebellum.	MBA:85|NLX:60355|BAMS:sc|DHBA:12749|MESH:D020824|GAID:733|NLXANAT:1005036	hp.json		http://purl.obolibrary.org/obo/UBERON_0005413		pheno_slim
HP:0003760	biolink:PhenotypicFeature	Percussion-induced rapid rolling muscle contractions	Mechanical percussion (i.e., striking a muscle with a reflex hammer) leads to spreading waves of muscle contractions that begin proximally and spread laterally across the muscle.	UMLS:C4280804	hp.json		http://purl.obolibrary.org/obo/HP_0003760		
UBERON:0005412	biolink:AnatomicalEntity	optic fissure	Groove that is in the developing ventral optic cup and through which blood vessels pass to the enclosed mesenchyme[ZFA]. a ventral fissure in the developing optic cup through which blood vessels pass to the enclosed mesenchyme[Free online medical dictionary].	XAO:0000474|EMAPA:17166|AAO:0011026|ZFA:0001284|VHOG:0000655|TAO:0001284|RETIRED_EHDAA2:0000249|MA:0001305|EHDAA2:0001319|EHDAA:4759	hp.json	ventral choroidal fissure|optic fissures|choroid fissure - optic fissure|optic stalk fissure|choroid fissure	http://purl.obolibrary.org/obo/UBERON_0005412		pheno_slim|vertebrate_core
CHEBI:17089	biolink:ChemicalSubstance	glycoprotein	A compound in which a carbohydrate component is covalently bound to a protein component.	KEGG:C00326	hp.json	glycoproteine|glycoproteins|a glycoprotein|glycoproteines|Glycoprotein|glicoproteina|Glykoprotein|Glykoproteine|glicoproteinas	http://purl.obolibrary.org/obo/CHEBI_17089		3_STAR
UBERON:0005411	biolink:AnatomicalEntity	bony otic capsule	The cartilage or bony capsule surrounding the inner ear mechanism.	EMAPA:17596|MA:0000252|EMAPA:37466	hp.json	otic capsule bone	http://purl.obolibrary.org/obo/UBERON_0005411		pheno_slim
UBERON:0005410	biolink:AnatomicalEntity	cartilaginous otic capsule	An otic capsule endochondral element that is composed primarily of cartilage tissue.	EMAPA:17596|TAO:0001500|EHDAA2:0001333|EMAPA:37467|EMAPA:18803|EHDAA:4704|ZFA:0001500	hp.json	auditory capsule|otic capsule cartilage element	http://purl.obolibrary.org/obo/UBERON_0005410		vertebrate_core
CHEBI:17087	biolink:ChemicalSubstance	ketone	A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H).	Wikipedia:Ketone|KEGG:C01450	hp.json	R-CO-R'|a ketone|Keton|ketones|Ketone|ketones|cetone	http://purl.obolibrary.org/obo/CHEBI_17087		3_STAR
CHEBI:17084	biolink:ChemicalSubstance	2-hydroxyglutaric acid	A 2-hydroxydicarboxylic acid that is glutaric acid in which one hydrogen alpha- to a carboxylic acid group is substituted by a hydroxy group.	KEGG:C02630|Wikipedia:Alpha-Hydroxyglutaric_acid|PMID:17439666|Beilstein:1723805|Reaxys:1723805|CAS:2889-31-8|MetaCyc:2-HYDROXYGLUTARIC_ACID|CAS:2889-31-8	hp.json	2-hydroxypentanedioic acid|2-hydroxyglutaric acid|alpha-hydroxyglutaric acid	http://purl.obolibrary.org/obo/CHEBI_17084		3_STAR
HP:0001118	biolink:PhenotypicFeature	Juvenile cataract	A type of cataract that is not apparent at birth but that arises in childhood or adolescence.	UMLS:C0302254|SNOMEDCT_US:399336001	hp.json		http://purl.obolibrary.org/obo/HP_0001118		
HP:0001119	biolink:PhenotypicFeature	Keratoglobus	Limbus-to-limbus corneal thinning, often greatest in the periphery, with globular protrusion of the cornea.	UMLS:C3887531	hp.json		http://purl.obolibrary.org/obo/HP_0001119		hposlim_core
HP:0001112	biolink:PhenotypicFeature	Leber optic atrophy	Degeneration of retinal ganglion cells and their axons.	UMLS:C0917796|SNOMEDCT_US:58610003|MSH:D029242	hp.json	Leber optic degeneration|Leber optic atrophy features	http://purl.obolibrary.org/obo/HP_0001112		
PATO:0001163	biolink:NamedThing	decreased concentration	A concentration which is lower relative to the normal or average.		hp.json	low concentration	http://purl.obolibrary.org/obo/PATO_0001163		relational_slim|value_slim
HP:0003774	biolink:PhenotypicFeature	Stage 5 chronic kidney disease	A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine.	SNOMEDCT_US:433146000|UMLS:C2316810	hp.json	Renal failure, endstage|End-stage renal disease|End stage renal disease|End-stage renal failure|End stage renal failure|Chronic renal failure|Stage 5 chronic kidney disease	http://purl.obolibrary.org/obo/HP_0003774		
PATO:0001164	biolink:NamedThing	dense	A physical quality which inheres in a bearer by virtue of the bearer's exhibiting density.		hp.json		http://purl.obolibrary.org/obo/PATO_0001164		value_slim|mpath_slim
HP:0001113	biolink:PhenotypicFeature	obsolete Early cataracts			hp.json		http://purl.obolibrary.org/obo/HP_0001113		
PATO:0001162	biolink:NamedThing	increased concentration	A concentration which is higher relative to the normal or average.		hp.json	high concentration	http://purl.obolibrary.org/obo/PATO_0001162		relational_slim|value_slim
CHEBI:32695	biolink:ChemicalSubstance	argininate		Gmelin:603497	hp.json	2-amino-5-guanidinopentanoate|arg(-)|2-amino-5-(carbamimidamido)pentanoate|argininate|arginine anion	http://purl.obolibrary.org/obo/CHEBI_32695		3_STAR
HP:0001116	biolink:PhenotypicFeature	Macular coloboma	A congenital defect of the macula distinct from coloboma associated with optic fissure closure defects. Macular coloboma is characterized by a sharply defined, rather large defect in the central area of the fundus that is oval or round, and coarsely pigmented.	MSH:C535968|UMLS:C1852767	hp.json	Coloboma of the macula	http://purl.obolibrary.org/obo/HP_0001116		
CHEBI:32696	biolink:ChemicalSubstance	argininium(1+)		Gmelin:1345599	hp.json	argininium(1+)|H2arg(+)|2-ammonio-5-guanidiniopentanoate|arginine|argininium|arginine monocation	http://purl.obolibrary.org/obo/CHEBI_32696		3_STAR
PATO:0001167	biolink:NamedThing	damaged	A structural quality inhering in a bearer by virtue of the bearer being harmed or injured or spoiled, such that its functionality is impaired.		hp.json		http://purl.obolibrary.org/obo/PATO_0001167		value_slim
HP:0003779	biolink:PhenotypicFeature	Antegonial notching of mandible		UMLS:C1844509	hp.json	Large antegonial notch of mandible|Deep antegonial notch of mandible	http://purl.obolibrary.org/obo/HP_0003779		
CHEBI:32697	biolink:ChemicalSubstance	argininium(2+)			hp.json	argininium(2+)|(1-carboxy-4-guanidiniobutyl)ammonium|argininediium|H3arg(2+)|arginine dication	http://purl.obolibrary.org/obo/CHEBI_32697		3_STAR
HP:0003778	biolink:PhenotypicFeature	Short mandibular rami		UMLS:C1841648|UMLS:C4280545	hp.json	Underdeveloped mandibular rami|Decreased height of mandibular ramus|Short body and ramus of mandible|Short mandibular ramus|Decreased size of mandibular ramus	http://purl.obolibrary.org/obo/HP_0003778		
HP:0001117	biolink:PhenotypicFeature	Sudden loss of visual acuity	Severe loss of visual acuity within hours or days. This is characteristic of Leber hereditary optic neuropathy.	UMLS:C4025803|UMLS:C4072828|UMLS:C4280600	hp.json	Sudden decrease in vision|Sudden central visual loss	http://purl.obolibrary.org/obo/HP_0001117		
HP:0001114	biolink:PhenotypicFeature	Xanthelasma	The presence of xanthomata in the skin of the eyelid.	SNOMEDCT_US:6400008|MSH:D014973|UMLS:C4280602|UMLS:C0302314|UMLS:C4280601|SNOMEDCT_US:75594004|UMLS:C0155210|SNOMEDCT_US:63103006	hp.json	Xanthelasma of eyelid|Xanthoma|Xanthelasma of periocular region|Fatty deposits on eyelids|Fatty deposits in skin around the eyes|Xanthoma of eyelid|Xanthoma of periocular region|Xanthelasma palpebrarum	http://purl.obolibrary.org/obo/HP_0001114		
HP:0003777	biolink:PhenotypicFeature	Pili torti	Pili (from Latin pilus, hair) torti (from Latin tortus, twisted) refers to short and brittle hairs that appear flattened and twisted when viewed through a microscope.	MSH:C562485|SNOMEDCT_US:17170005|UMLS:C0263491	hp.json	Flattened and twisted hair	http://purl.obolibrary.org/obo/HP_0003777		hposlim_core
HP:0001115	biolink:PhenotypicFeature	Posterior polar cataract	A polar cataract that affects the posterior pole of the lens.	UMLS:C1850191	hp.json	Polar cataract, posterior	http://purl.obolibrary.org/obo/HP_0001115		
UBERON:0005404	biolink:AnatomicalEntity	frontonasal suture	A suture between frontal and nasal bones.	MA:0002973|EMAPA:35359|FMA:52948	hp.json	articulation of the nasal bone with frontal bone|frontonasal suture of skull	http://purl.obolibrary.org/obo/UBERON_0005404		pheno_slim
UBERON:0005403	biolink:AnatomicalEntity	ventral striatum	A composite structure of the telencephalon that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the anterior perforated substance, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance (Heimer-1995; adapted from Brain Info).	EFO:0001936|BAMS:Ventral_striatum|PBA:10091|MA:0002972|BAMS:STRv|BAMS:StrV|FMA:77614|BTO:0004702|NLX:57107|DMBA:15858|EMAPA:36576|MESH:D066328|MBA:493	hp.json	striatum ventrale|striatum ventral region	http://purl.obolibrary.org/obo/UBERON_0005403		pheno_slim|efo_slim
HP:0003771	biolink:PhenotypicFeature	Pulp calcification	Pulp calcifications may appear as punctate calcifications, irregular, roughly spherical mineralized masses in any part of the pulp. It may occur isolated or associated to calcifications elsewhere such as the carotid arteries and kidneys. The diagnosis pulp calcifications can be established using radiological studies.	SNOMEDCT_US:57602001|UMLS:C1527284|MSH:D003784|UMLS:C4280546|UMLS:C4280259	hp.json	True pulp stones|Pulpoliths|Pulp denticles|Pulp stones|Pulp calcifications|False denticles|False pulp stones|True denticles	http://purl.obolibrary.org/obo/HP_0003771		
UBERON:0005402	biolink:AnatomicalEntity	philtrum	The vertical groove found on the median line of the upper lip, extending to the nose.	MA:0001577|FMA:59819|EHDAA:9280|EMAPA:17926|EHDAA2:0001462|VHOG:0000862	hp.json	philtral region of upper lip|medial cleft|infranasal depression|lip philtrum	http://purl.obolibrary.org/obo/UBERON_0005402		pheno_slim
UBERON:0005401	biolink:AnatomicalEntity	cerebral hemisphere gray matter	A gray matter that is part of a cerebral hemisphere.	BTO:0000823|FMA:61821|CALOHA:TS-2361|EMAPA:37477|MA:0000944	hp.json	cerebral hemisphere grey matter|cerebral gray matter|cerebral grey matter	http://purl.obolibrary.org/obo/UBERON_0005401		
UBERON:0005400	biolink:AnatomicalEntity	telencephalon arachnoid mater	An arachnoid mater that is part of a telencephalon.	MA:0000980|EMAPA:17775	hp.json	telencephalon arachnoid matter	http://purl.obolibrary.org/obo/UBERON_0005400		
GO:0016192	biolink:BiologicalProcess	vesicle-mediated transport	A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.		hp.json	vesicle transport|protein sorting along secretory pathway|vesicular transport|vesicle trafficking|nonselective vesicle transport	http://purl.obolibrary.org/obo/GO_0016192		goslim_candida|goslim_generic|goslim_pombe|goslim_pir|goslim_drosophila|goslim_aspergillus|goslim_chembl
PATO:0001579	biolink:NamedThing	contractility	A physical quality that is the ability to contract or shrink.		hp.json		http://purl.obolibrary.org/obo/PATO_0001579		scalar_slim|disposition_slim|attribute_slim
PATO:0001576	biolink:NamedThing	increased pressure	A pressure which is relatively high.		hp.json	high pressure	http://purl.obolibrary.org/obo/PATO_0001576		value_slim
PATO:0001571	biolink:NamedThing	dilated	A size quality inhering in a bearer by virtue of the bearer's being made wider or larger in all dimensions.		hp.json		http://purl.obolibrary.org/obo/PATO_0001571		value_slim|mpath_slim
PATO:0001575	biolink:NamedThing	decreased pressure	A pressure which is relatively low.		hp.json	low pressure	http://purl.obolibrary.org/obo/PATO_0001575		value_slim
PATO:0001581	biolink:NamedThing	decreased contractility	A contractility which is relatively low.		hp.json	low contractility	http://purl.obolibrary.org/obo/PATO_0001581		disposition_slim|value_slim
PATO:0001580	biolink:NamedThing	increased contractility	A contractility which is relatively high.		hp.json	high contractility	http://purl.obolibrary.org/obo/PATO_0001580		disposition_slim|value_slim
PATO:0001598	biolink:NamedThing	protruding	A quality inhering in a bearer by virtue of the bearer's extending out above or beyond a surface or boundary.		hp.json	protruding|relational protruding quality	http://purl.obolibrary.org/obo/PATO_0001598		value_slim
PATO:0001599	biolink:NamedThing	rotated	An oriented quality inhering in a bearer by virtue of the bearer's being relocated around an axis.		hp.json	rotation	http://purl.obolibrary.org/obo/PATO_0001599		value_slim|mpath_slim
PATO:0001592	biolink:NamedThing	increased curvature	A curvature which is relatively high.		hp.json		http://purl.obolibrary.org/obo/PATO_0001592		value_slim
PATO:0001593	biolink:NamedThing	decreased curvature	A curvature which is relatively low.		hp.json		http://purl.obolibrary.org/obo/PATO_0001593		value_slim
PATO:0001590	biolink:NamedThing	overlap with	A structural quality inhering in a bearer by virtue of the bearer's coinciding spatially, partially or wholly with another entity.		hp.json	overlap	http://purl.obolibrary.org/obo/PATO_0001590		relational_slim|value_slim
PATO:0001591	biolink:NamedThing	curvature	A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending.		hp.json		http://purl.obolibrary.org/obo/PATO_0001591		attribute_slim
PATO:0001596	biolink:NamedThing	increased depth	A depth quality which is relatively high.		hp.json	deep	http://purl.obolibrary.org/obo/PATO_0001596		value_slim
PATO:0001597	biolink:NamedThing	everted	An oriented quality inhering in a bearer by virtue of the bearer's being turned outward in placement.		hp.json		http://purl.obolibrary.org/obo/PATO_0001597		value_slim|mpath_slim
PATO:0001594	biolink:NamedThing	arched	A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch.		hp.json		http://purl.obolibrary.org/obo/PATO_0001594		cell_quality
PATO:0001595	biolink:NamedThing	depth	A 1-D extent quality inhering in a bearer by virtue of the bearer's downward or backward or inward dimension.		hp.json		http://purl.obolibrary.org/obo/PATO_0001595		scalar_slim|attribute_slim
GO:0100001	biolink:BiologicalProcess	regulation of skeletal muscle contraction by action potential	Any action potential process that regulates skeletal muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_0100001		
PATO:0001545	biolink:NamedThing	inflexible	A physical quality inhering in a bearer by virtue of the bearer's inability of being turned, bowed, or twisted without breaking.		hp.json	stiff|stiffness	http://purl.obolibrary.org/obo/PATO_0001545		disposition_slim|value_slim
PATO:0001546	biolink:NamedThing	quality of a solid	A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable.		hp.json	solidity	http://purl.obolibrary.org/obo/PATO_0001546		attribute_slim
PATO:0001543	biolink:NamedThing	flexibility	A physical quality inhering in a bearer by virtue of the bearer's disposition to being turned, bowed, or twisted without breaking.		hp.json		http://purl.obolibrary.org/obo/PATO_0001543		disposition_slim|attribute_slim
PATO:0001544	biolink:NamedThing	flexible			hp.json		http://purl.obolibrary.org/obo/PATO_0001544		
PATO:0001549	biolink:NamedThing	increased sensitivity toward	A sensitivity toward an external stimulus which is higher than normal/average.		hp.json	high sensitivity toward|increased sensitivity	http://purl.obolibrary.org/obo/PATO_0001549		value_slim|disposition_slim|relational_slim
PATO:0001547	biolink:NamedThing	quality of a gas	A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape.		hp.json	gaseous	http://purl.obolibrary.org/obo/PATO_0001547		attribute_slim
PATO:0001548	biolink:NamedThing	quality of a liquid	A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape.		hp.json	liquidity	http://purl.obolibrary.org/obo/PATO_0001548		attribute_slim
GO:0090138	biolink:BiologicalProcess	regulation of actin cytoskeleton organization by cell-cell adhesion	Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.		hp.json	regulation of actin cytoskeleton organisation by cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0090138		
GO:0090139	biolink:BiologicalProcess	mitochondrial chromosome packaging	A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure.		hp.json	mitochondrial DNA packaging	http://purl.obolibrary.org/obo/GO_0090139		
GO:0090132	biolink:BiologicalProcess	epithelium migration	The process in which the population of cells that make up an epithelium undergo directed movement.		hp.json		http://purl.obolibrary.org/obo/GO_0090132		
GO:0090130	biolink:BiologicalProcess	tissue migration	The process in which the population of cells that make up a tissue undergo directed movement.		hp.json		http://purl.obolibrary.org/obo/GO_0090130		
CHEBI:138675	biolink:ChemicalSubstance	gas molecular entity	Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa).	Wikipedia:https://en.wikipedia.org/wiki/Gas	hp.json	gaseous molecular entity|gaseous molecular entities|gas molecular entities	http://purl.obolibrary.org/obo/CHEBI_138675		3_STAR
PATO:0001555	biolink:NamedThing	has number of	The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts.	OBO_REL:has_part	hp.json	number|mereological quality|has or lacks parts of type|number of|extra or missing physical or functional parts|cardinality	http://purl.obolibrary.org/obo/PATO_0001555		relational_slim|attribute_slim
PATO:0001558	biolink:NamedThing	lacking processual parts	A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001558		relational_slim|value_slim
PATO:0001559	biolink:NamedThing	having extra function	A functionality quality which is held by the bearer when the latter is able to perform additional or different function(s).		hp.json	having supernumerary functions	http://purl.obolibrary.org/obo/PATO_0001559		disposition_slim|value_slim
GO:0016125	biolink:BiologicalProcess	sterol metabolic process	The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.		hp.json	sterol metabolism	http://purl.obolibrary.org/obo/GO_0016125		
PATO:0001552	biolink:NamedThing	decreased sensitivity of a process	A sensitivity of a process which is lower than normal or average.		hp.json	low sensitivity of occurrent|decreased sensitivity of occurrent	http://purl.obolibrary.org/obo/PATO_0001552		relational_slim|value_slim
PATO:0001550	biolink:NamedThing	decreased sensitivity toward	A sensitivity toward an external stimulus which is lower than normal/average.		hp.json	decreased sensitivity|low sensitivity toward	http://purl.obolibrary.org/obo/PATO_0001550		disposition_slim|relational_slim|value_slim
PATO:0001551	biolink:NamedThing	increased sensitivity of a process	A sensitivity of a process which is higher than normal or average.		hp.json	high sensitivity of occurrent|increased sensitivity of occurrent	http://purl.obolibrary.org/obo/PATO_0001551		relational_slim|value_slim
PATO:0001563	biolink:NamedThing	increased mass	A mass which is higher than normal or average.		hp.json	high mass|large mass	http://purl.obolibrary.org/obo/PATO_0001563		value_slim
GO:0016137	biolink:BiologicalProcess	glycoside metabolic process	The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound.		hp.json	O-glycoside metabolic process|glycoside metabolism|O-glycoside metabolism	http://purl.obolibrary.org/obo/GO_0016137		
PATO:0001564	biolink:NamedThing	extra or missing processual parts	A quality of a process inhering in a bearer by virtue of the bearer's processual parts.		hp.json		http://purl.obolibrary.org/obo/PATO_0001564		relational_slim
PATO:0001561	biolink:NamedThing	having extra processual parts	A quality of a process inhering in a bearer by virtue of the bearer's having additional processual parts.		hp.json	having supernumerary processual parts	http://purl.obolibrary.org/obo/PATO_0001561		relational_slim|value_slim
PATO:0001562	biolink:NamedThing	decreased mass	A mass which is lower than normal or average.		hp.json	low mass|small mass	http://purl.obolibrary.org/obo/PATO_0001562		value_slim
UBERON:0005076	biolink:AnatomicalEntity	hindbrain-spinal cord boundary	An anatomical boundary that adjacent_to a hindbrain and adjacent_to a spinal cord.		hp.json	hindbrain-spinal cord boundary region	http://purl.obolibrary.org/obo/UBERON_0005076		
UBERON:0005075	biolink:AnatomicalEntity	forebrain-midbrain boundary	An anatomical boundary that adjacent_to a forebrain and adjacent_to a midbrain.	ZFA:0001367|TAO:0001367|EMAPA:36449	hp.json	diencephalic-mesencephalic boundary|forebrain midbrain boundary|forebrain-midbrain boundary region	http://purl.obolibrary.org/obo/UBERON_0005075		
PATO:0001509	biolink:NamedThing	functionality	A quality of a single physical entity that arises by virtue of whether the bearer exhibits the ability to perform a regular function(s).		hp.json		http://purl.obolibrary.org/obo/PATO_0001509		scalar_slim|disposition_slim|attribute_slim
PATO:0001507	biolink:NamedThing	disrupted	A quality of a single process inhering in a bearer by virtue of the bearer's being interrupted of its normal course.		hp.json		http://purl.obolibrary.org/obo/PATO_0001507		value_slim|mpath_slim
CHEBI:81568	biolink:ChemicalSubstance	Luteinizing hormone		KEGG:C18183|CAS:9002-67-9	hp.json	ICSH|Interstitial cell stimulating hormone|LH	http://purl.obolibrary.org/obo/CHEBI_81568		2_STAR
PATO:0001500	biolink:NamedThing	tapered	A shape quality inhering in a bearer by virtue of the bearer's being gradually narrower or thinner toward one end.		hp.json	taper	http://purl.obolibrary.org/obo/PATO_0001500		value_slim|cell_quality
PATO:0001505	biolink:NamedThing	separated from	A structural quality inhering in a bearer by virtue of the bearer's not being in contact with another entity, or of no longer being connected or joined with another entity.		hp.json	splitted from|divided_from|discontiguous	http://purl.obolibrary.org/obo/PATO_0001505		relational_slim|value_slim
UBERON:0005068	biolink:AnatomicalEntity	neural rod	A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN].	ZFA:0000133|TAO:0000133|EFO:0003498	hp.json	neural tube rod	http://purl.obolibrary.org/obo/UBERON_0005068		efo_slim
UBERON:0005066	biolink:AnatomicalEntity	right ventricular trabecular myocardium			hp.json		http://purl.obolibrary.org/obo/UBERON_0005066		
UBERON:0005064	biolink:AnatomicalEntity	left ventricular trabecular myocardium			hp.json		http://purl.obolibrary.org/obo/UBERON_0005064		
UBERON:0005062	biolink:AnatomicalEntity	neural fold	One of the two elevated edges of the neural groove[GO,MP].	FMA:295618|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1364|Wikipedia:Neural_fold|SCTID:361461009|EHDAA2:0001249|NCIT:C34223|XAO:0004087|UMLS:C0814993	hp.json	medullary fold	http://purl.obolibrary.org/obo/UBERON_0005062		pheno_slim
UBERON:0005061	biolink:AnatomicalEntity	neural groove	The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds.	AAO:0011071|EMAPA:35594|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1363|NCIT:C34224|FMA:295624|SCTID:361463007|UMLS:C0814992|Wikipedia:Neural_groove|XAO:0000248	hp.json		http://purl.obolibrary.org/obo/UBERON_0005061		
CHEBI:20612	biolink:ChemicalSubstance	5-methyltetrahydrofolate	A group of heterocyclic compounds based on the 5-methyl-5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.		hp.json	5-methyltetrahydrofolates	http://purl.obolibrary.org/obo/CHEBI_20612		3_STAR
PATO:0001512	biolink:NamedThing	punctate	A pattern inhering in a surface by virtue of the bearer's being marked by the presence of dots, punctures, points or pits.		hp.json	spotted|dotted|stippled	http://purl.obolibrary.org/obo/PATO_0001512		value_slim|mpath_slim
PATO:0001510	biolink:NamedThing	functional	A functionality quality held by the bearer when the latter is able to perform a regular function(s).		hp.json		http://purl.obolibrary.org/obo/PATO_0001510		disposition_slim|value_slim
PATO:0001511	biolink:NamedThing	non-functional	A disfunctional quality held by the bearer when the latter is unable to perform a regular function(s).		hp.json	failure|defective|disfunctional|functional failure	http://purl.obolibrary.org/obo/PATO_0001511		disposition_slim|value_slim
UBERON:0005057	biolink:AnatomicalEntity	immune organ	An organ that is part of a immune system [Automatically generated definition].		hp.json	immune system organ	http://purl.obolibrary.org/obo/UBERON_0005057		organ_slim|pheno_slim
UBERON:0005056	biolink:AnatomicalEntity	external female genitalia	An external genitalia that is part of a female reproductive system [Automatically generated definition].	BTO:0003100|FMA:45649|SCTID:362234008|EMAPA:30984|galen:FemaleExternalGenitalia	hp.json	female external genitalia|external genitalia of female reproductive system|external female genital organ|organa genitalia feminina externa	http://purl.obolibrary.org/obo/UBERON_0005056		organ_slim|pheno_slim
UBERON:0005055	biolink:AnatomicalEntity	zone of long bone	An organ part that is part of a long bone [Automatically generated definition].	FMA:24008	hp.json	long bone zone	http://purl.obolibrary.org/obo/UBERON_0005055		uberon_slim
UBERON:0005051	biolink:AnatomicalEntity	mediastinum testis	The mediastinum testis is a network of fibrous connective tissue that extends from the upper to near the lower extremity of the testis, and is wider above than below. From its front and sides numerous imperfect septa (trabeculæ) are given off, which radiate toward the surface of the organ, and are attached to the tunica albuginea. They divide the interior of the organ into a number of incomplete spaces, called lobules. These are somewhat cone-shaped, being broad at their bases at the surface of the gland, and becoming narrower as they converge to the mediastinum. The mediastinum supports the rete testis and blood vessels of the testis in their passage to and from the substance of the gland[WP].	FMA:19812|EMAPA:18331|MA:0003240	hp.json	body of highmore|hilum of testicle|testis mediastinum|mediastinum of testis	http://purl.obolibrary.org/obo/UBERON_0005051		
UBERON:0005058	biolink:AnatomicalEntity	hemolymphoid system gland	A gland that is part of a hemolymphoid system [Automatically generated definition].	EMAPA:18766|MA:0002962	hp.json	haemolymphoid system gland|hemopoietic or lymphoid gland|hemopoietic or lymphoid gland|hemopoietic or lymphoid organ	http://purl.obolibrary.org/obo/UBERON_0005058		organ_slim
UBERON:0005046	biolink:AnatomicalEntity	mucosa of hard palate	A mucosa that is part of a hard palate [Automatically generated definition].	FMA:59783	hp.json	hard palate mucosa|organ mucosa of hard palate|mucous membrane of hard palate|hard palate mucous membrane	http://purl.obolibrary.org/obo/UBERON_0005046		
UBERON:0005045	biolink:AnatomicalEntity	mucosa of ethmoidal sinus	A mucosa that is part of a ethmoid sinus [Automatically generated definition].	FMA:59776	hp.json	ethmoid sinus organ mucosa|organ mucosa of ethmoid sinus|ethmoid sinus mucosa of organ|mucous membrane of ethmoid sinus|mucosa of ethmoid sinus|mucosa of organ of ethmoid sinus|ethmoid sinus mucous membrane|ethmoidal sinus mucosa|ethmoid sinus mucosa	http://purl.obolibrary.org/obo/UBERON_0005045		
UBERON:0005044	biolink:AnatomicalEntity	mucosa of pharyngotympanic tube	A mucosa that is part of a pharyngotympanic tube [Automatically generated definition].	FMA:60109	hp.json	mucous membrane of pharyngotympanic tube|pharyngotympanic tube mucosa of organ|organ mucosa of pharyngotympanic tube|mucosa of organ of internal auditory tube|tunica mucosa (tuba auditoria)|pharyngotympanic tube mucosa|pharyngotympanic tube organ mucosa|mucosa of internal auditory tube|tunica mucosa (tuba auditiva)|mucous membrane of internal auditory tube|mucosa of organ of pharyngotympanic tube|organ mucosa of internal auditory tube|pharyngotympanic tube mucous membrane|mucous membrane of auditory tube|auditory tube mucosa of organ|organ mucosa of auditory tube|mucosa of auditory tube|internal auditory tube mucosa of organ|internal auditory tube mucosa|mucuous membrane of eustachian tube|internal auditory tube organ mucosa|auditory tube mucous membrane|mucosa of organ of auditory tube|auditory tube mucosa|auditory tube organ mucosa|mucuous membrane of pharyngotympanic tube|internal auditory tube mucous membrane	http://purl.obolibrary.org/obo/UBERON_0005044		
UBERON:0005043	biolink:AnatomicalEntity	mucosa of nasolacrimal duct	A mucosa that is part of a nasolacrimal duct [Automatically generated definition].	FMA:59664	hp.json	nasolacrimal duct mucosa|nasolacrimal duct organ mucosa|mucosa of organ of nasolacrimal duct|nasolacrimal duct mucous membrane|nasolacrimal ductal mucosa|mucous membrane of nasolacrimal duct|nasolacrimal duct mucosa of organ|organ mucosa of nasolacrimal duct	http://purl.obolibrary.org/obo/UBERON_0005043		
UBERON:0005042	biolink:AnatomicalEntity	inner epithelial layer of tympanic membrane	A portion of the tympanic cavity epithelium which makes up the outer (cuticular) layer of the tympanic membrane.	FMA:56844	hp.json	mucosa of tympanic membrane|mucous layer of tympanic membrane|tympanic membrane external middle ear cavity epithelial component|tympanic membrane mucosa|mucous stratum of tympanic membrane	http://purl.obolibrary.org/obo/UBERON_0005042		
UBERON:0005040	biolink:AnatomicalEntity	mucosa of terminal bronchiole	A mucosa that is part of a terminal bronchiole [Automatically generated definition].	FMA:263232	hp.json	mucosa of bronchiolus terminalis|mucous membrane of bronchiolus terminalis|organ mucosa of bronchiolus terminalis|organ mucosa of terminal bronchiole|mucous membrane of terminal bronchiole|terminal bronchiole mucosa of organ|bronchiolus terminalis mucosa|bronchiolus terminalis mucosa of organ|terminal bronchiole mucosa|bronchiolus terminalis organ mucosa|terminal bronchiole organ mucosa|mucosa of organ of terminal bronchiole|terminal bronchiole mucous membrane|bronchiolus terminalis mucous membrane|mucosa of organ of bronchiolus terminalis	http://purl.obolibrary.org/obo/UBERON_0005040		
UBERON:0005049	biolink:AnatomicalEntity	mucosa of infundibulum of uterine tube	A mucosa that is part of a uterine tube infundibulum [Automatically generated definition].	FMA:18357	hp.json	mucosa of uterine tube infundibulum|mucosa of infundibulum of fallopian tube|uterine tube infundibulum mucous membrane|mucosa of organ of uterine tube infundibulum|mucosa of infundibulum of oviduct|uterine tube infundibulum mucosa|uterine tube infundibulum organ mucosa|mucous membrane of uterine tube infundibulum|organ mucosa of uterine tube infundibulum|uterine tube infundibulum mucosa of organ	http://purl.obolibrary.org/obo/UBERON_0005049		
UBERON:0005048	biolink:AnatomicalEntity	mucosa of uterine tube	A mucosa that is part of a fallopian tube [Automatically generated definition].	FMA:18319	hp.json	fallopian tube organ mucosa|mucosa of oviduct|uterine tube mucosa of organ|mucosa of fallopian tube|mucous membrane of fallopian tube|organ mucosa of fallopian tube|uterine tube mucosa|uterine tube organ mucosa|uterine tube mucous membrane|fallopian tube mucosa of organ|mucosa of organ of uterine tube|uterine tubal mucosa|tunica mucosa tubae uterinae|fallopian tube mucous membrane|organ mucosa of uterine tube|mucous membrane of uterine tube|mucosa of organ of fallopian tube|fallopian tube mucosa	http://purl.obolibrary.org/obo/UBERON_0005048		human_reference_atlas
UBERON:0005047	biolink:AnatomicalEntity	mucosa of vocal fold	A mucosa that is part of a vocal cord [Automatically generated definition].	FMA:64017	hp.json	true vocal cord organ mucosa|mucosa of vocal cord|mucous membrane of vocal cord|organ mucosa of vocal cord|mucosa of glottis|true vocal cord mucosa of organ|organ mucosa of true vocal cord|mucous membrane of true vocal cord|mucosa of true vocal cord|vocal fold mucosa|vocal cord mucosa of organ|true vocal cord mucous membrane|mucosa of organ of true vocal cord|vocal cord mucous membrane|vocal cord mucosa|mucosa of organ of vocal cord|vocal cord organ mucosa|true vocal cord mucosa	http://purl.obolibrary.org/obo/UBERON_0005047		
NCBITaxon:7742	biolink:OrganismalEntity	Vertebrata <vertebrates>		GC_ID:1	hp.json	Vertebrata|vertebrates|vertebrates	http://purl.obolibrary.org/obo/NCBITaxon_7742		
PR:000017477	biolink:Protein	xanthine dehydrogenase/oxidase	A protein that is a translation product of the human XDH gene or a 1:1 ortholog thereof.	IUPHARobj:2646	hp.json	XDH|XDHA	http://purl.obolibrary.org/obo/PR_000017477		
UBERON:0005092	biolink:AnatomicalEntity	right horn of sinus venosus		EHDAA:484|VHOG:0000489|EMAPA:16239|FMA:70318|EHDAA2:0001841	hp.json	sinus venosus right horn	http://purl.obolibrary.org/obo/UBERON_0005092		
UBERON:0005090	biolink:AnatomicalEntity	muscle structure	Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO].	EMAPA:32715|FMA:30316	hp.json	muscle element|musculus|muscle	http://purl.obolibrary.org/obo/UBERON_0005090		
UBERON:0005095	biolink:AnatomicalEntity	kidney rudiment			hp.json	kidney anlage	http://purl.obolibrary.org/obo/UBERON_0005095		
NCBITaxon:7711	biolink:OrganismalEntity	Chordata		GC_ID:1	hp.json	chordates|chordates	http://purl.obolibrary.org/obo/NCBITaxon_7711		
UBERON:0005082	biolink:AnatomicalEntity	tube lumen	A hole in a tube[GO].	RETIRED_EHDAA2:0003078|AEO:0000078|EHDAA2:0004618	hp.json		http://purl.obolibrary.org/obo/UBERON_0005082		
UBERON:0005081	biolink:AnatomicalEntity	ureter ureteric bud	The portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005081		
UBERON:0005080	biolink:AnatomicalEntity	metanephric ureteric bud	The portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005080		
UBERON:0005089	biolink:AnatomicalEntity	sweat gland placode	An sweat gland placode is a thickening of the ectoderm that will give rise to the sweat gland bud[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005089		
UBERON:0005088	biolink:AnatomicalEntity	sebaceous gland placode	A sebaceous gland placode is a thickening of the ectoderm that will give rise to the sebaceous gland bud[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005088		
UBERON:0005087	biolink:AnatomicalEntity	tooth placode	An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud[GO].	ZFA:0001153|BTO:0001511|TAO:0001153	hp.json	tooth primordium|dental anlage|odontogenic placode|dental primordium|tooth anlage|tooth germ|dental placode	http://purl.obolibrary.org/obo/UBERON_0005087		
UBERON:0005086	biolink:AnatomicalEntity	hair follicle placode	A bud-like thickening in the epidermis consisting of elongated keratinocytes, which at the distal end are in touch with numerous aggregated specialized dermal fibroblasts, the dermal condensate.	EMAPA:36479	hp.json	hair gem|hair placode|hair germ|vibrissa placode|hair peg	http://purl.obolibrary.org/obo/UBERON_0005086		
UBERON:0005085	biolink:AnatomicalEntity	ectodermal placode	An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO].	AEO:0000218	hp.json	epithelial placode	http://purl.obolibrary.org/obo/UBERON_0005085		
GO:0006704	biolink:NamedThing	glucocorticoid biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0006704		
GO:0006705	biolink:NamedThing	mineralocorticoid biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0006705		
UBERON:0007775	biolink:AnatomicalEntity	secondary tooth	A tooth that forms after a primary tooth.	NCIT:C33313|UMLS:C0348070|FMA:55654	hp.json	permanent tooth|dentes permanentes	http://purl.obolibrary.org/obo/UBERON_0007775		pheno_slim
HP:0003467	biolink:PhenotypicFeature	Atlantoaxial instability	Abnormally increased movement at the junction between the first cervical (atlas) and the second cervical (axis) vertebrae as a result of either a bony or ligamentous anomaly.	SNOMEDCT_US:202820009|UMLS:C0410653	hp.json		http://purl.obolibrary.org/obo/HP_0003467		hposlim_core
HP:0003466	biolink:PhenotypicFeature	Paradoxical increased cortisol secretion on dexamethasone suppression test		UMLS:C1968855	hp.json		http://purl.obolibrary.org/obo/HP_0003466		
UBERON:0005111	biolink:AnatomicalEntity	metanephric pyramid	Metanephric pyramids are the conical masses that constitute the renal medulla in a metanephros; they contain the loops of Henle and the medullary collecting ducts[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005111		
UBERON:0005110	biolink:AnatomicalEntity	metanephric nephron	A metanephric nephron is the functional unit of the metanephros[GO].	VHOG:0000719	hp.json		http://purl.obolibrary.org/obo/UBERON_0005110		
HP:0003465	biolink:PhenotypicFeature	Elevated 8(9)-cholestenol		UMLS:C1840014	hp.json		http://purl.obolibrary.org/obo/HP_0003465		
UBERON:0007778	biolink:AnatomicalEntity	umbilical artery endothelium	An endothelium that is part of a umbilical artery.	BTO:0000857	hp.json		http://purl.obolibrary.org/obo/UBERON_0007778		
HP:0003464	biolink:PhenotypicFeature	obsolete Abnormal cholesterol homeostasis			hp.json		http://purl.obolibrary.org/obo/HP_0003464		
UBERON:0007779	biolink:AnatomicalEntity	transudate	Any bodily fluid that has passed through a membrane such as the capillary wall, as a result of unbalanced hydrostatic and osmotic forces.	ncithesaurus:Transudate|MESH:D005122|GAID:1195|FMA:12276	hp.json	plasma ultrafiltrate	http://purl.obolibrary.org/obo/UBERON_0007779		
HP:0003469	biolink:PhenotypicFeature	Peripheral dysmyelination	Defective structure and function of myelin sheaths. Dysmyelination is distinguished from demyleination where there is destruction or damage of previously normal myelination.	UMLS:C4025610	hp.json		http://purl.obolibrary.org/obo/HP_0003469		
HP:0003468	biolink:PhenotypicFeature	Abnormal vertebral morphology	An abnormality of one or more of the vertebrae.	SNOMEDCT_US:205043005|UMLS:C4020840|SNOMEDCT_US:74877002|UMLS:C4020839|Fyler:4108|UMLS:C0158775	hp.json	Abnormal vertebral bodies|Vertebral anomalies|Abnormal vertebrae|Multiple vertebral anomalies|Abnormality of the vertebrae	http://purl.obolibrary.org/obo/HP_0003468		
HP:0003463	biolink:PhenotypicFeature	Increased extraneuronal autofluorescent lipopigment	Lipofuscin, a generic term applied to autofluorescent lipopigment, is a mixture of protein and lipid that accumulates in most aging cells, particularly those involved in high lipid turnover (e.g., the adrenal medulla) or phagocytosis of other cell types (e g., the retinal pigment epithelium or RPE; macrophage). This term pertains if there is an increase in the extraneuronal accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient.	UMLS:C1859828	hp.json	Lipopigment in extraneuronal cells	http://purl.obolibrary.org/obo/HP_0003463		
UBERON:0007771	biolink:AnatomicalEntity	epidermis gland	A gland that is part of a epidermis.	FMA:59153	hp.json	epidermal gland|gland of epidermis	http://purl.obolibrary.org/obo/UBERON_0007771		grouping_class
UBERON:0007772	biolink:AnatomicalEntity	scrotal sweat	Any portion of sweat that is produced by a sweat gland of the scrotum.	FMA:73266	hp.json	sweat of scrotum|sweat of scrotal sac|scrotum sweat	http://purl.obolibrary.org/obo/UBERON_0007772		
UBERON:0005115	biolink:AnatomicalEntity	metanephric cortical collecting duct	The metanephric cortical collecting duct is the portion of the metanephric collecting duct that resides in the renal cortex[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005115		
HP:0003462	biolink:PhenotypicFeature	Elevated 8-dehydrocholesterol		UMLS:C1840013	hp.json		http://purl.obolibrary.org/obo/HP_0003462		
UBERON:0007773	biolink:AnatomicalEntity	scrotal sweat gland	Any sweat gland that is part of a scrotum.	EMAPA:29743	hp.json		http://purl.obolibrary.org/obo/UBERON_0007773		organ_slim
HP:0003461	biolink:PhenotypicFeature	Increased urinary O-linked sialopeptides	Excretion of peptides conjugated to sialic acid in the urine.	UMLS:C1836533	hp.json		http://purl.obolibrary.org/obo/HP_0003461		
HP:0003460	biolink:PhenotypicFeature	Decreased circulating total IgA	Undetectable serum immunoglobulin A level at a value < 5 mg/dL (0.05 g/L).	UMLS:C4025611	hp.json	Decreased total IgA in blood|Total immunoglobulin A deficiency	http://purl.obolibrary.org/obo/HP_0003460		
UBERON:0007774	biolink:AnatomicalEntity	secondary dentition	The teeth of adulthood that either replace or are added to the complement of deciduous teeth. (Boucher's Clinical Dental Terminology, 4th ed).	MESH:D019229|GAID:1251|FMA:75152	hp.json	set of permanent teeth|adult dentition|dentes permanentes|permanent teeth|secondary dentition|permanent dentition|set of secondary teeth	http://purl.obolibrary.org/obo/UBERON_0007774		pheno_slim
UBERON:0005113	biolink:AnatomicalEntity	metanephric cortex mesenchyme		EHDAA2:0001140	hp.json		http://purl.obolibrary.org/obo/UBERON_0005113		
PR:P01831	biolink:Protein	Thy-1 membrane glycoprotein (mouse)	A Thy-1 membrane glycoprotein that is encoded in the genome of mouse.	UniProtKB:P01831	hp.json	CD90 (mouse)|Thy-1 antigen (mouse)|Thy1|mTHY1|Thy-1	http://purl.obolibrary.org/obo/PR_P01831		
NCBITaxon:7776	biolink:OrganismalEntity	Gnathostomata <vertebrates>		GC_ID:1	hp.json	Gnathostomata|jawed vertebrates	http://purl.obolibrary.org/obo/NCBITaxon_7776		
HP:0003477	biolink:PhenotypicFeature	Peripheral axonal neuropathy	An abnormality characterized by disruption of the normal functioning of peripheral axons.	UMLS:C0270921|UMLS:C1263857|SNOMEDCT_US:128208007|SNOMEDCT_US:60703000	hp.json	Axonal peripheral neuropathy|Axonal neuropathy	http://purl.obolibrary.org/obo/HP_0003477		
HP:0003470	biolink:PhenotypicFeature	Paralysis	Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Motor paralysis results from deficits of the upper motor neurons (corticospinal, corticobulbar, or subcorticospinal). Motor paralysis is often accompanied by an impairment in the facility of movement.	MSH:D010243|SNOMEDCT_US:44695005|UMLS:C0522224	hp.json	Paralysis|Inability to move	http://purl.obolibrary.org/obo/HP_0003470		
UBERON:0005109	biolink:AnatomicalEntity	metanephric smooth muscle tissue	Any smooth muscle tissue that is part of a metanephros.		hp.json		http://purl.obolibrary.org/obo/UBERON_0005109		
UBERON:0005108	biolink:AnatomicalEntity	metanephric epithelium	An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005108		
UBERON:0005106	biolink:AnatomicalEntity	metanephric tubule	A metanephric tubule is an epithelial tube that is part of the metanephros[GO].	VHOG:0001526	hp.json		http://purl.obolibrary.org/obo/UBERON_0005106		
HP:0003474	biolink:PhenotypicFeature	Somatic sensory dysfunction	An abnormality of the primary sensation that is mediated by peripheral nerves (pain, temperature, touch, vibration, joint position). The word hypoesthesia (or hypesthesia) refers to a reduction in cutaneous sensation to a specific type of testing.	SNOMEDCT_US:398026008|SNOMEDCT_US:59073000|MSH:D006987|SNOMEDCT_US:397974008|UMLS:C0020580	hp.json	Sensory impairment	http://purl.obolibrary.org/obo/HP_0003474		
HP:0003473	biolink:PhenotypicFeature	Fatigable weakness	A type of weakness that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C0947912	hp.json	Myasthenia|Generalised muscle weakness due to defect at the neuromuscular junction|Fatigable weakness of limb muscles|Myasthenic weakness|Proximal muscle weakness due to defect at the neuromuscular junction|Generalized muscle weakness due to defect at the neuromuscular junction	http://purl.obolibrary.org/obo/HP_0003473		
UBERON:0007762	biolink:AnatomicalEntity	metatarsophalangeal joint of pedal digit 5	A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 5.	FMA:35240|EMAPA:26484	hp.json	metatarsophalangeal joint of fifth toe|metatarsophalangeal joint of fifth digit of foot|metatarsophalangeal joint of little toe|metatarsophalangeal joint of pedal digit V	http://purl.obolibrary.org/obo/UBERON_0007762		pheno_slim
HP:0003472	biolink:PhenotypicFeature	Hypocalcemic tetany	Hyperexcitability of the neuromuscular system related to abnormally low level of calcium in the blood, resulting in carpopedal or generalized spasms.	UMLS:C0151940|SNOMEDCT_US:190869004	hp.json		http://purl.obolibrary.org/obo/HP_0003472		
UBERON:0005103	biolink:AnatomicalEntity	mesonephric epithelium	An epithelium that is part of a mesonephros [Automatically generated definition].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005103		
CHEBI:32529	biolink:ChemicalSubstance	histidinate(1-)		Gmelin:364417|Beilstein:3959092	hp.json	2-amino-3-(1H-imidazol-4-yl)propanoate|hydrogen histidinate|histidine anion|histidinate(1-)	http://purl.obolibrary.org/obo/CHEBI_32529		3_STAR
HP:0003445	biolink:PhenotypicFeature	EMG: neuropathic changes	The presence of characteristic findings of denervation on electromyography (fibrillations, positive sharp waves, and giant motor unit potentials).	UMLS:C4021727	hp.json	EMG: neurogenic abnormalities|EMG: neurogenic changes|EMG: neurogenic findings	http://purl.obolibrary.org/obo/HP_0003445		
UBERON:0007753	biolink:AnatomicalEntity	metatarsophalangeal joint of pedal digit 2	A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 2.	EMAPA:26442|FMA:35231	hp.json	metatarsophalangeal joint of pedal digit II|metatarsophalangeal joint of second digit of foot|metatarsophalangeal joint of second toe	http://purl.obolibrary.org/obo/UBERON_0007753		pheno_slim
HP:0003444	biolink:PhenotypicFeature	EMG: chronic denervation signs	Evidence of chronic denervation on electromyography.	UMLS:C4025614	hp.json		http://purl.obolibrary.org/obo/HP_0003444		
HP:0003443	biolink:PhenotypicFeature	Decreased size of nerve terminals	A reduction in the size of nerve terminals.	UMLS:C4025615	hp.json		http://purl.obolibrary.org/obo/HP_0003443		
UBERON:0007756	biolink:AnatomicalEntity	metatarsophalangeal joint of pedal digit 3	A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 3.	FMA:35234|EMAPA:26460	hp.json	metatarsophalangeal joint of third toe|metatarsophalangeal joint of pedal digit III|metatarsophalangeal joint of third digit of foot	http://purl.obolibrary.org/obo/UBERON_0007756		pheno_slim
HP:0003449	biolink:PhenotypicFeature	Cold-induced muscle cramps	Sudden and involuntary contractions of one or more muscles brought on by exposure to cold temperatures.	UMLS:C1861675	hp.json		http://purl.obolibrary.org/obo/HP_0003449		
HP:0003448	biolink:PhenotypicFeature	Decreased sensory nerve conduction velocity	Reduced speed of conduction of the action potential along a sensory nerve.	UMLS:C1849148	hp.json	Decreased sensory NCV|Decreased sensory nerve conduction velocities	http://purl.obolibrary.org/obo/HP_0003448		
HP:0003447	biolink:PhenotypicFeature	Axonal loss	A reduction in the number of axons in the peripheral nervous system.	UMLS:C1832338	hp.json		http://purl.obolibrary.org/obo/HP_0003447		
UBERON:0007759	biolink:AnatomicalEntity	metatarsophalangeal joint of pedal digit 4	A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 4.	EMAPA:26472|FMA:35237	hp.json	metatarsophalangeal joint of fourth digit of foot|metatarsophalangeal joint of fourth toe|metatarsophalangeal joint of pedal digit IV	http://purl.obolibrary.org/obo/UBERON_0007759		pheno_slim
UBERON:0032748	biolink:AnatomicalEntity	sacral spinal cord ventral horn		BIRNLEX:1457	hp.json	sacral spinal cord ventral horn|sacral spinal cord anterior horn|sacral spinal cord ventral horn	http://purl.obolibrary.org/obo/UBERON_0032748		
UBERON:0007750	biolink:AnatomicalEntity	metatarsophalangeal joint of pedal digit 1	A skeletal joint that connects a metatarsal bone and connects a distal phalanx of pedal digit 1.	NCIT:C102321|FMA:35228|EMAPA:26436	hp.json	first metatarsophalangeal joint|metatarsophalangeal joint of great toe|metatarsophalangeal joint of first toe|metatarsophalangeal joint of first digit of foot|metatarsophalangeal joint of big toe|metatarsophalangeal joint of pedal digit I	http://purl.obolibrary.org/obo/UBERON_0007750		pheno_slim
HP:0003440	biolink:PhenotypicFeature	Horizontal sacrum		UMLS:C1850558	hp.json		http://purl.obolibrary.org/obo/HP_0003440		hposlim_core
CHEBI:533015	biolink:ChemicalSubstance	3,3',5-triiodo-L-thyronine zwitterion	The amino acid zwitterion formed from 3,3',5-triiodo-L-thyronine by tranfer of a proton from the carboxy group to the amino group. It is the major species at pH 7.3.	MetaCyc:CPD-10813	hp.json	3,3',5-triiodo-L-thyronine|(S)-2-Amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-propionic acid|(2S)-2-azaniumyl-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate	http://purl.obolibrary.org/obo/CHEBI_533015		3_STAR
HP:0003456	biolink:PhenotypicFeature	Low urinary cyclic AMP response to PTH administration		UMLS:C1864105	hp.json		http://purl.obolibrary.org/obo/HP_0003456		
HP:0003455	biolink:PhenotypicFeature	Elevated circulating long chain fatty acid concentration	Increased concentration of long-chain fatty acids in the blood circulation.	UMLS:C1859241	hp.json	Elevated long chain fatty acids|Elevated serum long-chain fatty acids|Increased serum long-chain fatty acids	http://purl.obolibrary.org/obo/HP_0003455		
UBERON:0007744	biolink:AnatomicalEntity	metacarpophalangeal joint of manual digit 4	A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 4.	FMA:35258|EMAPA:25066	hp.json	metacarpophalangeal joint of fourth finger|carpometacarpophalangeal joint of fourth digit|metacarpo-phalangeal joint of digit 4 of fore-paw|metacarpophalangeal joint of manual digit IV|metacarpophalangeal joint of fourth digit of hand|metacarpophalangeal joint of ring finger|metacarpophalangeal joint of digit 4	http://purl.obolibrary.org/obo/UBERON_0007744		pheno_slim
HP:0003454	biolink:PhenotypicFeature	Platelet antibody positive	The presence in the serum of autoantibodies directed against thrombocytes.	UMLS:C1858980	hp.json	Platelet antibody	http://purl.obolibrary.org/obo/HP_0003454		
CHEBI:32530	biolink:ChemicalSubstance	histidinate(2-)			hp.json	2-amino-3-imidazol-1-id-4-ylpropanoate|histidinate|histidinate(2-)|histidine dianion	http://purl.obolibrary.org/obo/CHEBI_32530		3_STAR
HP:0003453	biolink:PhenotypicFeature	Antineutrophil antibody positivity	The presence of autoantibodies in the serum that react against neutrophils.	UMLS:C1858981	hp.json	Neutrophil antibody positive|Antineutrophil antibodies	http://purl.obolibrary.org/obo/HP_0003453		
CHEBI:32531	biolink:ChemicalSubstance	histidinium(1+)			hp.json	histidine monocation|histidinium|2-ammonio-3-(1H-imidazol-3-ium-4-yl)propanoate|histidinium(1+)	http://purl.obolibrary.org/obo/CHEBI_32531		3_STAR
CHEBI:32532	biolink:ChemicalSubstance	histidinium(2+)		Gmelin:1151904	hp.json	histidine dication|histidinium(2+)|4-(2-ammonio-2-carboxyethyl)-1H-imidazol-3-ium|histidinediium	http://purl.obolibrary.org/obo/CHEBI_32532		3_STAR
UBERON:0007747	biolink:AnatomicalEntity	metacarpophalangeal joint of manual digit 5	A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 5.	EMAPA:25069|FMA:35261	hp.json	metacarpophalangeal joint of fifth finger|metacarpophalangeal joint of manual digit V|metacarpo-phalangeal joint of digit 5 of fore-paw|metacarpophalangeal joint of fifth digit of hand|metacarpophalangeal joint of little finger|metacarpophalangeal joint of digit 5	http://purl.obolibrary.org/obo/UBERON_0007747		pheno_slim
HP:0003459	biolink:PhenotypicFeature	Polyclonal elevation of IgM	A heterogeneous increase in IgM immunoglobulins characterized by a diffuse band on serum electrophoresis.	UMLS:C4025612	hp.json		http://purl.obolibrary.org/obo/HP_0003459		
HP:0003458	biolink:PhenotypicFeature	EMG: myopathic abnormalities	The presence of abnormal electromyographic patterns indicative of myopathy, such as small-short polyphasic motor unit potentials.	UMLS:C4021726	hp.json	EMG: myopathy|EMG: myopathic changes|Myopathic electromyogram	http://purl.obolibrary.org/obo/HP_0003458		
HP:0003457	biolink:PhenotypicFeature	EMG abnormality	Abnormal results of investigations using electromyography (EMG).	UMLS:C0476403|SNOMEDCT_US:274523007	hp.json	Electromyogram abnormal|Abnormal EMG|Abnormal electromyography finding|EMG abnormalities	http://purl.obolibrary.org/obo/HP_0003457		
HP:0003452	biolink:PhenotypicFeature	Increased serum iron		SNOMEDCT_US:165624002|UMLS:C0151900	hp.json		http://purl.obolibrary.org/obo/HP_0003452		
HP:0003451	biolink:PhenotypicFeature	Increased rate of premature chromosome condensation	An increased rate of premature chromosome condensation.	UMLS:C4025613	hp.json		http://purl.obolibrary.org/obo/HP_0003451		
HP:0003450	biolink:PhenotypicFeature	Axonal regeneration	The presence of axonal regeneration following a previous axonal lesion.	UMLS:C1854454	hp.json	Regenerative activity on nerve biopsy	http://purl.obolibrary.org/obo/HP_0003450		
UBERON:0007741	biolink:AnatomicalEntity	metacarpophalangeal joint of manual digit 3	A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 3.	FMA:35255|EMAPA:25063	hp.json	metacarpophalangeal joint of manual digit III|metacarpo-phalangeal joint of digit 3 of fore-paw|carpometacarpophalangeal joint of third digit|metacarpophalangeal joint of third finger|metacarpophalangeal joint of digit 3|metacarpophalangeal joint of middle finger|metacarpophalangeal joint of third digit of hand	http://purl.obolibrary.org/obo/UBERON_0007741		pheno_slim
CHEBI:32504	biolink:ChemicalSubstance	phenylalaninate	An aromatic amino-acid anion that is the conjugate base of phenylalanine, arising from deprotonation of the carboxy group.	Gmelin:329083	hp.json	2-amino-3-phenylpropanoate|phenylalaninate|phenylalanine anion	http://purl.obolibrary.org/obo/CHEBI_32504		3_STAR
CHEBI:32505	biolink:ChemicalSubstance	phenylalaninium	An alpha-amino-acid cation that is the conjugate acid of phenylalanine, arising from protonation of the amino group.		hp.json	phenylalaninium|1-carboxy-2-phenylethanaminium|phenylalanine cation	http://purl.obolibrary.org/obo/CHEBI_32505		3_STAR
CHEBI:32507	biolink:ChemicalSubstance	glycinium	An alpha-amino-acid cation that is the conjugate acid of glycine, arising from protonation of the amino.	Gmelin:323509	hp.json	H2gly(+)|carboxymethanaminium|NH3(+)-CH2-COOH|glycine cation|glycinium	http://purl.obolibrary.org/obo/CHEBI_32507		3_STAR
CHEBI:32508	biolink:ChemicalSubstance	glycinate	An alpha-amino-acid anion that is the conjugate base of glycine, arising from deprotonation of the carboxy group.	UM-BBD_compID:c0559|Gmelin:81890|Reaxys:1852023|Beilstein:1852023	hp.json	glycine anion|H2N-CH2-COO(-)|aminoacetate|gly(-)|glycinate	http://purl.obolibrary.org/obo/CHEBI_32508		3_STAR
UBERON:0005156	biolink:AnatomicalEntity	reproductive structure	Any anatomical structure that is part of the reproductive system.		hp.json	reproductive system structure|reproductive system element	http://purl.obolibrary.org/obo/UBERON_0005156		grouping_class
UBERON:0005154	biolink:AnatomicalEntity	epithelial cord	A cord of epithelial cells without a lumen and usually several cells thick.	EHDAA2:0004052|AEO:0000216	hp.json		http://purl.obolibrary.org/obo/UBERON_0005154		
UBERON:0005153	biolink:AnatomicalEntity	epithelial bud	A bud is a protrusion that forms from an epithelial sheet by localized folding.	BTO:0001639	hp.json		http://purl.obolibrary.org/obo/UBERON_0005153		
UBERON:0005158	biolink:AnatomicalEntity	parenchyma of central nervous system	The functional tissue of the central nervous system consisting of neurons and glial cells.		hp.json	central nervous system parenchyma|CNS parenchyma|parenchyma of CNS|parenchyma of central nervous system	http://purl.obolibrary.org/obo/UBERON_0005158		
UBERON:0005157	biolink:AnatomicalEntity	epithelial fold	An epithelial sheet bent on a linear axis.		hp.json		http://purl.obolibrary.org/obo/UBERON_0005157		
UBERON:0005145	biolink:AnatomicalEntity	metanephric comma-shaped body	The metanephric comma-shaped body is the precursor structure to the metanephric S-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005145		
UBERON:0005144	biolink:AnatomicalEntity	metanephric glomerular capillary	This process pertains to the initial formation of a structure from unspecified parts[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005144		
UBERON:0005148	biolink:AnatomicalEntity	metanephric S-shaped body	The metanephric S-shaped body is the successor of the metanephric comma-shaped body that contributes to the morphogenesis of a nephron in the metanephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005148		
UBERON:0005147	biolink:AnatomicalEntity	metanephric renal vesicle	The renal vesicle is the primordial structure of the metanephric nephron epithelium, and is formed by the condensation of mesenchymal cells[GO].	EHDAA2:0001245|EHDAA:9346|EMAPA:27678	hp.json	metanephric vesicle	http://purl.obolibrary.org/obo/UBERON_0005147		
UBERON:0005146	biolink:AnatomicalEntity	metanephric nephron tubule	A metanephric nephron tubule is an epithelial tube that is part of the metanephric nephron, the functional part of the metanephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005146		
CHEBI:68566	biolink:ChemicalSubstance	3-methylglutaric acid	An alpha,omega-dicarboxylic acid that is glutaric acid substituted at position 3 by a methyl group.	PMID:22770225|LIPID_MAPS_instance:LMFA01170117|CAS:626-51-7|HMDB:HMDB0000752|Reaxys:1759502	hp.json	beta-methylglutaric acid|3-methylpentanedioic acid	http://purl.obolibrary.org/obo/CHEBI_68566		3_STAR
HP:0003489	biolink:PhenotypicFeature	Acute episodes of neuropathic symptoms		UMLS:C1867971	hp.json		http://purl.obolibrary.org/obo/HP_0003489		
UBERON:0005134	biolink:AnatomicalEntity	metanephric nephron epithelium	The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005134		
UBERON:0007798	biolink:AnatomicalEntity	vascular system	Anatomical system that consists of all blood and lymph vessels.	CALOHA:TS-2053|UMLS:C0489903|EHDAA2:0004520|MA:0002718|BTO:0001085|NCIT:C33854|EMAPA:35905	hp.json		http://purl.obolibrary.org/obo/UBERON_0007798		pheno_slim
UBERON:0005133	biolink:AnatomicalEntity	metanephric glomerulus vasculature	The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005133		
HP:0003487	biolink:PhenotypicFeature	Babinski sign	Upturning of the big toe (and sometimes fanning of the other toes) in response to stimulation of the sole of the foot. If the Babinski sign is present it can indicate damage to the corticospinal tract.	UMLS:C0034935|SNOMEDCT_US:366575004|SNOMEDCT_US:246586009	hp.json	Extensor plantar reflexes|Positive Babinski sign|Extensor plantar responses|Extensor plantar response	http://purl.obolibrary.org/obo/HP_0003487		
HP:0003481	biolink:PhenotypicFeature	Segmental peripheral demyelination/remyelination	A segmental pattern of demyelination and regeneration (remyelination) affecting peripheral nerves.	UMLS:C1843077	hp.json	Segmental demyelination/remyelination	http://purl.obolibrary.org/obo/HP_0003481		
UBERON:0005137	biolink:AnatomicalEntity	metanephric capsule	The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005137		
HP:0003484	biolink:PhenotypicFeature	Upper limb muscle weakness	Weakness of the muscles of the arms.	UMLS:C1698196|SNOMEDCT_US:713512009	hp.json	Weak arm|Decreased arm strength	http://purl.obolibrary.org/obo/HP_0003484		
UBERON:0007794	biolink:AnatomicalEntity	secretion of serous gland	Any fluid produced by a serous gland.	Wikipedia:Serous_fluid	hp.json	serosal fluid|serous gland fluid|serosal fluid|serous fluid	http://purl.obolibrary.org/obo/UBERON_0007794		
UBERON:0005136	biolink:AnatomicalEntity	metanephric glomerular endothelium	The metanephric glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus of the metanephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005136		
UBERON:0005135	biolink:AnatomicalEntity	metanephric glomerular epithelium	A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros[GO].		hp.json		http://purl.obolibrary.org/obo/UBERON_0005135		
HP:0003482	biolink:PhenotypicFeature	EMG: axonal abnormality	Electromyographic (EMG) findings characteristic of axonal neuropathy, with normal or slightly decreased nerve conduction velocities, normal or slightly prolonged distal latencies, but significantly reduced motor potentials and sensory amplitudes. There may be spontaneous activity upon needle EMG studies, such as increased insertional activity, positive sharp waves, and fibrillation potentials.	UMLS:C4025609	hp.json		http://purl.obolibrary.org/obo/HP_0003482		
HP:0003498	biolink:PhenotypicFeature	Disproportionate short stature	A kind of short stature in which different regions of the body are shortened to differing extents.	UMLS:C0878659|UMLS:C1846797	hp.json	Short stature, disproportionate|Short stature, severe disproportionate	http://purl.obolibrary.org/obo/HP_0003498		
HP:0003492	biolink:PhenotypicFeature	High urinary gonadotropin level	An elevated concentration of a gonadotropin hormone (stimulating hormone or luteinizing hormone) in the urine, consistent with the diagnosis of primary hypogonadism.	UMLS:C4025606	hp.json		http://purl.obolibrary.org/obo/HP_0003492		
HP:0003491	biolink:PhenotypicFeature	Elevated urine pyrophosphate	An abnormally increased diphosphate(4-) concentration in the urine. Diphosphate(4-), as ester with two phosphate groups, is also known as pyrophosphate.	UMLS:C4025607	hp.json		http://purl.obolibrary.org/obo/HP_0003491		
HP:0003490	biolink:PhenotypicFeature	obsolete Defective dehydrogenation of isovaleryl CoA and butyryl CoA			hp.json		http://purl.obolibrary.org/obo/HP_0003490		
HP:0003496	biolink:PhenotypicFeature	Increased circulating IgM level	An abnormally increased level of immunoglobulin M in blood.	UMLS:C1839972	hp.json	Increased IgM levels|Increased levels of IgM	http://purl.obolibrary.org/obo/HP_0003496		
HP:0003495	biolink:PhenotypicFeature	GM2-ganglioside accumulation	Cellular accumulation of GM2 gangliosides.	UMLS:C1848920	hp.json		http://purl.obolibrary.org/obo/HP_0003495		
HP:0003494	biolink:PhenotypicFeature	obsolete Loss of heterozygosity, multiple chromosomes			hp.json		http://purl.obolibrary.org/obo/HP_0003494		
HP:0003493	biolink:PhenotypicFeature	Antinuclear antibody positivity	The presence of autoantibodies in the serum that react against nuclei or nuclear components.	SNOMEDCT_US:165850001|UMLS:C0151480	hp.json	Antinuclear antibodies|Antinuclear antibody positive|Serum antinuclear antibody|Elevated antinuclear antibody	http://purl.obolibrary.org/obo/HP_0003493		
GO:0006783	biolink:BiologicalProcess	heme biosynthetic process	The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.	MetaCyc:HEMESYN2-PWY	hp.json	heme anabolism|haem biosynthesis|haem biosynthetic process|heme synthesis|heme biosynthesis|heme formation	http://purl.obolibrary.org/obo/GO_0006783		
GO:0016101	biolink:BiologicalProcess	diterpenoid metabolic process	The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units.		hp.json	diterpene metabolic process|diterpenoid metabolism|diterpene metabolism	http://purl.obolibrary.org/obo/GO_0016101		
GO:0006796	biolink:BiologicalProcess	phosphate-containing compound metabolic process	The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.		hp.json	phosphate metabolic process|phosphate metabolism	http://purl.obolibrary.org/obo/GO_0006796		
GO:0006793	biolink:BiologicalProcess	phosphorus metabolic process	The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).		hp.json	phosphorus metabolism	http://purl.obolibrary.org/obo/GO_0006793		goslim_pir
GO:0006790	biolink:BiologicalProcess	sulfur compound metabolic process	The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.	Wikipedia:Sulfur_metabolism	hp.json	sulphur metabolism|sulphur metabolic process|sulfur metabolism	http://purl.obolibrary.org/obo/GO_0006790		prokaryote_subset|goslim_pombe|goslim_pir|goslim_drosophila|goslim_chembl|goslim_generic
CHEBI:173085	biolink:ChemicalSubstance	ferroptosis inducer	Any substance that induces or promotes ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.	PMID:31899616|PMID:32015325|PMID:34012798|PMID:33167414|Wikipedia:Ferroptosis	hp.json	ferroptosis inducers	http://purl.obolibrary.org/obo/CHEBI_173085		3_STAR
GO:0006766	biolink:BiologicalProcess	vitamin metabolic process	The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.		hp.json	vitamin metabolism	http://purl.obolibrary.org/obo/GO_0006766		goslim_drosophila|goslim_yeast|goslim_candida|goslim_generic|goslim_pir|goslim_pombe
GO:0006767	biolink:BiologicalProcess	water-soluble vitamin metabolic process	The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.		hp.json	water-soluble vitamin metabolism	http://purl.obolibrary.org/obo/GO_0006767		
GO:0090022	biolink:BiologicalProcess	regulation of neutrophil chemotaxis	Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.		hp.json		http://purl.obolibrary.org/obo/GO_0090022		
GO:0090023	biolink:BiologicalProcess	positive regulation of neutrophil chemotaxis	Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.		hp.json		http://purl.obolibrary.org/obo/GO_0090023		
GO:0090026	biolink:BiologicalProcess	positive regulation of monocyte chemotaxis	Any process that increases the frequency, rate, or extent of monocyte chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_0090026		
GO:0090027	biolink:BiologicalProcess	negative regulation of monocyte chemotaxis	Any process that decreases the frequency, rate, or extent of monocyte chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_0090027		
GO:0090024	biolink:BiologicalProcess	negative regulation of neutrophil chemotaxis	Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.		hp.json		http://purl.obolibrary.org/obo/GO_0090024		
GO:0090025	biolink:BiologicalProcess	regulation of monocyte chemotaxis	Any process that modulates the frequency, rate, or extent of monocyte chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_0090025		
GO:0006779	biolink:BiologicalProcess	porphyrin-containing compound biosynthetic process	The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.		hp.json	porphyrin biosynthetic process|porphyrin biosynthesis|porphyrin anabolism|porphyrin synthesis|porphyrin formation	http://purl.obolibrary.org/obo/GO_0006779		
GO:0006778	biolink:BiologicalProcess	porphyrin-containing compound metabolic process	The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.		hp.json	porphyrin metabolism|porphyrin metabolic process	http://purl.obolibrary.org/obo/GO_0006778		
GO:0090030	biolink:NamedThing	regulation of steroid hormone biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0090030		
GO:0006775	biolink:BiologicalProcess	fat-soluble vitamin metabolic process	The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.		hp.json	fat-soluble vitamin metabolism	http://purl.obolibrary.org/obo/GO_0006775		
GO:0006776	biolink:BiologicalProcess	vitamin A metabolic process	The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene.		hp.json	vitamin A metabolism	http://purl.obolibrary.org/obo/GO_0006776		
GO:0090031	biolink:NamedThing	positive regulation of steroid hormone biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0090031		
GO:0090032	biolink:NamedThing	negative regulation of steroid hormone biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0090032		
UBERON:0007728	biolink:AnatomicalEntity	interphalangeal joint of pedal digit 5	An interphalangeal joint of pes that is part of a pedal digit 5.	EMAPA:26478|FMA:35365	hp.json	interphalangeal joint of fifth digit of foot|interphalangeal joint of little toe|interphalangeal joint of pedal digit V|interphalangeal joint of fifth toe	http://purl.obolibrary.org/obo/UBERON_0007728		
UBERON:0007729	biolink:AnatomicalEntity	interphalangeal joint of manual digit 2	An interphalangeal joint of manus that is part of a manual digit 2.	EMAPA:25061|FMA:35397	hp.json	interphalangeal joint of second digit of hand|interphalangeal joint of manual digit II|interphalangeal joint of second finger|interphalangeal joint of index finger	http://purl.obolibrary.org/obo/UBERON_0007729		
HP:0003429	biolink:PhenotypicFeature	CNS hypomyelination	Reduced amount of myelin in the central nervous system resulting from defective myelinogenesis.	UMLS:C0544820|UMLS:C4025616|SNOMEDCT_US:111007000	hp.json		http://purl.obolibrary.org/obo/HP_0003429		
PATO:0001499	biolink:NamedThing	spherical	A spheroid quality inhering in a bearer by virtue of the bearer's resembling a ball (a sphere whose equatorial diameter is equal to the polar diameter).		hp.json	globular|rotund	http://purl.obolibrary.org/obo/PATO_0001499		value_slim|mpath_slim|cell_quality
UBERON:0007731	biolink:AnatomicalEntity	interphalangeal joint of manual digit 4	An interphalangeal joint of manus that is part of a manual digit 4.	EMAPA:25067|FMA:35403	hp.json	interphalangeal joint of fourth digit of hand|interphalangeal joint of fourth finger|interphalangeal joint of manual digit IV|interphalangeal joint of ring finger	http://purl.obolibrary.org/obo/UBERON_0007731		
HP:0003423	biolink:PhenotypicFeature	Thoracolumbar kyphoscoliosis		UMLS:C1859335	hp.json	Dorsolumbar kyphosis	http://purl.obolibrary.org/obo/HP_0003423		
HP:0003422	biolink:PhenotypicFeature	Vertebral segmentation defect	An abnormality related to a defect of vertebral separation during development.	UMLS:C0432163|SNOMEDCT_US:205455005	hp.json	Abnormal spinal segmentation	http://purl.obolibrary.org/obo/HP_0003422		hposlim_core
UBERON:0007732	biolink:AnatomicalEntity	interphalangeal joint of manual digit 5	An interphalangeal joint of manus that is part of a manual digit 5.	FMA:35407|EMAPA:25070	hp.json	interphalangeal joint of fifth finger|interphalangeal joint of manual digit V|interphalangeal joint of fifth digit of hand|interphalangeal joint of little finger	http://purl.obolibrary.org/obo/UBERON_0007732		
HP:0003421	biolink:PhenotypicFeature	obsolete Platyspondyly (childhood)			hp.json		http://purl.obolibrary.org/obo/HP_0003421		
UBERON:0007735	biolink:AnatomicalEntity	metacarpophalangeal joint of manual digit 1	A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 1.	FMA:35249|EMAPA:25057	hp.json	metacarpophalangeal joint of digit 1|metacarpophalangeal joint of manual digit I|metacarpophalangeal joint of thumb|metacarpo-phalangeal joint of digit 1 of fore-paw|metacarpophalangeal joint of first digit of hand	http://purl.obolibrary.org/obo/UBERON_0007735		pheno_slim
HP:0003427	biolink:PhenotypicFeature	Thenar muscle weakness		UMLS:C1832276	hp.json		http://purl.obolibrary.org/obo/HP_0003427		
HP:0003426	biolink:PhenotypicFeature	First dorsal interossei muscle atrophy		UMLS:C1832278	hp.json		http://purl.obolibrary.org/obo/HP_0003426		
PATO:0001495	biolink:NamedThing	notched	A concave quality inhering in a bearer by virtue of the bearer's shape being a V-shaped cut.		hp.json	indented	http://purl.obolibrary.org/obo/PATO_0001495		value_slim|mpath_slim|cell_quality
UBERON:0007738	biolink:AnatomicalEntity	metacarpophalangeal joint of manual digit 2	A skeletal joint that connects a metacarpal bone and connects a proximal phalanx of manual digit 2.	FMA:35252|EMAPA:25060	hp.json	metacarpophalangeal joint of second digit of hand|metacarpophalangeal joint of digit 2|metacarpo-phalangeal joint of digit 2 of fore-paw|metacarpophalangeal joint of manual digit II|metacarpophalangeal joint of second finger|metacarpophalangeal joint of index finger	http://purl.obolibrary.org/obo/UBERON_0007738		
GO:0090087	biolink:BiologicalProcess	regulation of peptide transport	Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0090087		
UBERON:0007730	biolink:AnatomicalEntity	interphalangeal joint of manual digit 3	An interphalangeal joint of manus that is part of a manual digit 3.	FMA:35400|EMAPA:25064	hp.json	interphalangeal joint of third digit of hand|interphalangeal joint of manual digit III|interphalangeal joint of third finger|interphalangeal joint of middle finger	http://purl.obolibrary.org/obo/UBERON_0007730		
GO:0090091	biolink:BiologicalProcess	positive regulation of extracellular matrix disassembly	Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.		hp.json		http://purl.obolibrary.org/obo/GO_0090091		
GO:0006757	biolink:BiologicalProcess	ATP generation from ADP	The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP.		hp.json	ADP phosphorylation	http://purl.obolibrary.org/obo/GO_0006757		
GO:0006753	biolink:BiologicalProcess	nucleoside phosphate metabolic process	The chemical reactions and pathways involving any phosphorylated nucleoside.		hp.json	nucleoside phosphate metabolism	http://purl.obolibrary.org/obo/GO_0006753		
UBERON:0007719	biolink:AnatomicalEntity	bone of reproductive organ	A bone that is part of a reproductive organ.		hp.json	baculum|os penis/os clitoris	http://purl.obolibrary.org/obo/UBERON_0007719		
HP:0003434	biolink:PhenotypicFeature	Sensory ataxic neuropathy		UMLS:C1843859	hp.json		http://purl.obolibrary.org/obo/HP_0003434		
UBERON:0007721	biolink:AnatomicalEntity	interphalangeal joint of pes	The interphalangeal articulations of the foot (articulations of the phalanges) are ginglymoid joints, and each has a plantar and two collateral ligaments. The arrangement of these ligaments is similar to that in the metatarsophalangeal articulations: the Extensor tendons supply the places of dorsal ligaments.	MESH:D014033|EMAPA:36337|FMA:35225|NCIT:C32867|NCIT:C33789|UMLS:C0040356	hp.json	interphalangeal joint of foot|hindlimb digit inter-phalangeal joint|toe joint|interphalangeal joint of toe|foot interphalangeal joint	http://purl.obolibrary.org/obo/UBERON_0007721		pheno_slim
UBERON:0007722	biolink:AnatomicalEntity	interphalangeal joint of manus	The interphalangeal articulations of hand are hinge-joints of the phalanges of the hand. There are two sets (except in the thumb): 'proximal interphalangeal joints' (PIP), those between the first (also called proximal) and second (intermediate) phalanges 'distal interphalangeal joints' (DIP), those between the second and third (distal) phalanges A similar group of articulations also function in the toes.	UMLS:C0016125|EMAPA:36336|NCIT:C32868|FMA:35285	hp.json	articulations of the digits|interphalangeal articulations of hand|IP joint|interphalangeal joints of hand|interphalangeal joint of finger|articulationes interphalangeae manus|interphalangeal joint of hand|articulationes digitorum manus	http://purl.obolibrary.org/obo/UBERON_0007722		pheno_slim
HP:0003431	biolink:PhenotypicFeature	Decreased motor nerve conduction velocity	A type of decreased nerve conduction velocity that affects the motor neuron.	UMLS:C1858729	hp.json	Reduced motor nerve conduction velocity|Decreased motor NCV|Decreased motor nerve conduction velocities	http://purl.obolibrary.org/obo/HP_0003431		
UBERON:0007723	biolink:AnatomicalEntity	interphalangeal joint of manual digit 1	An interphalangeal joint of manus that is part of a manual digit 1.	FMA:35312|EMAPA:25058|NCIT:C102306	hp.json	interphalangeal joint of thumb|interphalangeal joint of hand digit 1|interphalangeal joint of manual digit I|interphalangeal joint of first digit of hand|interphalangeal joint of manual digit 1|interphalangeal joint of pollex	http://purl.obolibrary.org/obo/UBERON_0007723		pheno_slim
UBERON:0007724	biolink:AnatomicalEntity	interphalangeal joint of pedal digit 1	An interphalangeal joint of pes that is part of a pedal digit 1.	FMA:35353|EMAPA:26430	hp.json	interphalangeal joint of pedal digit I|interphalangeal joint of foot digit 1|interphalangeal joint of hallux|interphalangeal joint of first digit of pes|interphalangeal joint of great toe|interphalangeal joint of pedal digit 1|interphalangeal joint of first toe|interphalangeal joint of first digit of foot|interphalangeal joint of big toe	http://purl.obolibrary.org/obo/UBERON_0007724		
HP:0003438	biolink:PhenotypicFeature	Absent Achilles reflex	Absence of the Achilles reflex (also known as the ankle jerk reflex), which can normally be elicited by tapping the tendon is tapped while the foot is dorsiflexed.	MSH:D012021|UMLS:C0558845|SNOMEDCT_US:274818004	hp.json	Absent ankle reflexes	http://purl.obolibrary.org/obo/HP_0003438		
UBERON:0007725	biolink:AnatomicalEntity	interphalangeal joint of pedal digit 2	An interphalangeal joint of pes that is part of a pedal digit 2.	EMAPA:26448|FMA:35356	hp.json	interphalangeal joint of second digit of foot|interphalangeal joint of pedal digit II|interphalangeal joint of second toe	http://purl.obolibrary.org/obo/UBERON_0007725		
HP:0003436	biolink:PhenotypicFeature	Prolonged miniature endplate currents	An abnormal prolongation of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction.	UMLS:C1864238	hp.json	Prolonged MEPC|Prolonged miniature endplate potentials|Prolonged MEPP	http://purl.obolibrary.org/obo/HP_0003436		
UBERON:0007726	biolink:AnatomicalEntity	interphalangeal joint of pedal digit 3	An interphalangeal joint of pes that is part of a pedal digit 3.	FMA:35359|EMAPA:26454	hp.json	interphalangeal joint of pedal digit III|interphalangeal joint of third digit of foot|interphalangeal joint of third toe	http://purl.obolibrary.org/obo/UBERON_0007726		
UBERON:0007727	biolink:AnatomicalEntity	interphalangeal joint of pedal digit 4	An interphalangeal joint of pes that is part of a pedal digit 4.	EMAPA:26466|FMA:35362	hp.json	interphalangeal joint of fourth toe|interphalangeal joint of fourth digit of foot|interphalangeal joint of pedal digit IV	http://purl.obolibrary.org/obo/UBERON_0007727		
HP:0003435	biolink:PhenotypicFeature	Cold-induced hand cramps		UMLS:C1832279	hp.json		http://purl.obolibrary.org/obo/HP_0003435		
GO:0006725	biolink:BiologicalProcess	cellular aromatic compound metabolic process	The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.		hp.json	aromatic compound metabolism|aromatic hydrocarbon metabolism|aromatic hydrocarbon metabolic process	http://purl.obolibrary.org/obo/GO_0006725		goslim_pir
GO:0090063	biolink:BiologicalProcess	positive regulation of microtubule nucleation	Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0090063		
GO:0006720	biolink:BiologicalProcess	isoprenoid metabolic process	The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.		hp.json	polyterpene metabolic process|polyisoprenoid metabolism|isoprenoid metabolism|polyisoprenoid metabolic process|polyterpene metabolism	http://purl.obolibrary.org/obo/GO_0006720		
GO:0006721	biolink:BiologicalProcess	terpenoid metabolic process	The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups.		hp.json	terpenoid metabolism	http://purl.obolibrary.org/obo/GO_0006721		
HP:0003409	biolink:PhenotypicFeature	Distal sensory impairment of all modalities	Reduced ability to sense pain, temperature, touch, vibration stimuli in the distal regions of the extremities.	UMLS:C1836527	hp.json	Distal sensory loss to all modalities	http://purl.obolibrary.org/obo/HP_0003409		
UBERON:0007709	biolink:AnatomicalEntity	superior cerebellar peduncle of pons		BIRNLEX:1726|FMA:72495|BAMS:scpp|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=833	hp.json	SCPP|superior cerebellar peduncle of the pons|pedunculus cerebellaris superior (pontis)|superior cerebellar peduncle of pons|SCPP	http://purl.obolibrary.org/obo/UBERON_0007709		pheno_slim
HP:0003406	biolink:PhenotypicFeature	Peripheral nerve compression		UMLS:C1851414	hp.json		http://purl.obolibrary.org/obo/HP_0003406		
CHEBI:741548	biolink:ChemicalSubstance	ethylmalonic acid	A dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group.	PMID:23161776|PMID:6860317|Reaxys:774334|CAS:601-75-2|CAS:516-05-2|PMID:22133302|CAS:601-75-2|HMDB:HMDB0000622|PMID:20187168	hp.json	ethylpropanedioic acid|alpha-carboxybutyric acid|1,1-propanedicarboxylic acid|2-ethylmalonic acid	http://purl.obolibrary.org/obo/CHEBI_741548		3_STAR
HP:0003401	biolink:PhenotypicFeature	Paresthesia	Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause.	UMLS:C0030554|SNOMEDCT_US:91019004|MSH:D010292	hp.json	Pins and needles feeling|Tingling|Paresthesias	http://purl.obolibrary.org/obo/HP_0003401		
HP:0003400	biolink:PhenotypicFeature	Basal lamina onion bulb formation	A type of onion bulb formation prominently affecting the area of the basal lamina.	UMLS:C1866637	hp.json	Basal lamina 'onion bulb' formations on nerve biopsy	http://purl.obolibrary.org/obo/HP_0003400		
CHEBI:32563	biolink:ChemicalSubstance	lysinate	An alpha-amino-acid anion that is the conjugate base of lysine, arising from deprotonation of the carboxy group.	Gmelin:815095	hp.json	lys(-)|lysinate(1-)|lysinate|lysine anion|2,6-diaminohexanoate	http://purl.obolibrary.org/obo/CHEBI_32563		3_STAR
CHEBI:32564	biolink:ChemicalSubstance	lysinium(1+)	An alpha-amino-acid cation that is the conjugate acid of lysine, having two cationic amino groups and an anionic carboxy group.		hp.json	lysine monocation|2,6-diammoniohexanoate|lysinium|lysinium(1+)	http://purl.obolibrary.org/obo/CHEBI_32564		3_STAR
HP:0003405	biolink:PhenotypicFeature	Diffuse axonal swelling		UMLS:C1865417	hp.json		http://purl.obolibrary.org/obo/HP_0003405		
CHEBI:32565	biolink:ChemicalSubstance	lysinium(2+)	An alpha-amino-acid cation obtained by protonation of both amino groups of lysine.		hp.json	lysine dication|lysinium(2+)|1-carboxypentane-1,5-diaminium|lysinediium	http://purl.obolibrary.org/obo/CHEBI_32565		3_STAR
HP:0003403	biolink:PhenotypicFeature	EMG: decremental response of compound muscle action potential to repetitive nerve stimulation	A compound muscle action potential (CMAP) is a type of electromyography (EMG). CMAP refers to a group of almost simultaneous action potentials from several muscle fibers in the same area evoked by stimulation of the supplying motor nerve and are recorded as one multipeaked summated action potential. This abnormality refers to a greater than normal decrease in the amplitude during the course of the investigation.	UMLS:C4021728|UMLS:C4020841	hp.json	EMG: decrement at repetitive stimulation|EMG: decremental response of CMAP to repetitive nerve stimulation	http://purl.obolibrary.org/obo/HP_0003403		
HP:0003402	biolink:PhenotypicFeature	Decreased miniature endplate potentials	An abnormal reduction in the amplitude of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction.	UMLS:C1853952	hp.json	Small miniature endplate potentials|Small miniature endplate currents|Decreased MEPP	http://purl.obolibrary.org/obo/HP_0003402		
GO:0090068	biolink:BiologicalProcess	positive regulation of cell cycle process	Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.		hp.json		http://purl.obolibrary.org/obo/GO_0090068		
GO:0090069	biolink:BiologicalProcess	regulation of ribosome biogenesis	Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.		hp.json		http://purl.obolibrary.org/obo/GO_0090069		
GO:0090070	biolink:BiologicalProcess	positive regulation of ribosome biogenesis	Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.		hp.json		http://purl.obolibrary.org/obo/GO_0090070		
GO:0090071	biolink:BiologicalProcess	negative regulation of ribosome biogenesis	Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.		hp.json		http://purl.obolibrary.org/obo/GO_0090071		
HP:0003419	biolink:PhenotypicFeature	Low back pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the lower back.	SNOMEDCT_US:279039007|MSH:D017116|UMLS:C0024031	hp.json	Lower back pain	http://purl.obolibrary.org/obo/HP_0003419		
HP:0003418	biolink:PhenotypicFeature	Back pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.	UMLS:C0004604|SNOMEDCT_US:161891005|MSH:D001416	hp.json	Back pain	http://purl.obolibrary.org/obo/HP_0003418		
HP:0003417	biolink:PhenotypicFeature	Coronal cleft vertebrae	Frontal schisis (cleft or cleavage) of vertebral bodies.	UMLS:C1834954	hp.json	Coronal vertebral clefts|Vertebral coronal clefts|Coronal clefts|coronal cleft of vertebrae	http://purl.obolibrary.org/obo/HP_0003417		
HP:0003411	biolink:PhenotypicFeature	Proximal femoral metaphyseal irregularity	Irregularity of the normally smooth surface of the proximal metaphysis of the femur.	UMLS:C1836320	hp.json	Irregular proximal femoral metaphyses	http://purl.obolibrary.org/obo/HP_0003411		
UBERON:0007702	biolink:AnatomicalEntity	tract of brain	An axon tract that is part of a brain.	FMA:83848	hp.json	brain tract|landmark tracts	http://purl.obolibrary.org/obo/UBERON_0007702		
HP:0003416	biolink:PhenotypicFeature	Spinal canal stenosis	An abnormal narrowing of the spinal canal.	UMLS:C1861329	hp.json	Spinal stenosis|Narrow spinal canal	http://purl.obolibrary.org/obo/HP_0003416		hposlim_core
HP:0003414	biolink:PhenotypicFeature	Atlantoaxial dislocation	Partial dislocation of the atlantoaxial joint.	SNOMEDCT_US:45179004|UMLS:C0263905|SNOMEDCT_US:263042007	hp.json	Atlanto-axial subluxation|Atlantoaxial subluxation	http://purl.obolibrary.org/obo/HP_0003414		
HP:0003413	biolink:PhenotypicFeature	Atlantoaxial abnormality	An anomaly of the atlantoaxial joint, i.e., of the joint between the first (atlas) and second (axis) cervical vertebrae.	UMLS:C4025617	hp.json		http://purl.obolibrary.org/obo/HP_0003413		
MPATH:64	biolink:NamedThing	developmental dysplasia	Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth.		hp.json		http://purl.obolibrary.org/obo/MPATH_64		
PATO:0001457	biolink:NamedThing	sensitivity of a process	A quality of a process inhering in bearer by virtue of the bearer's disposition to respond to stimulation.		hp.json	sensitivity of occurrent	http://purl.obolibrary.org/obo/PATO_0001457		disposition_slim|relational_slim|attribute_slim
MPATH:62	biolink:NamedThing	cyst	Formation of an epithelium bounded cavity not associated with neoplasia.		hp.json		http://purl.obolibrary.org/obo/MPATH_62		
MPATH:68	biolink:NamedThing	diverticulum	A blind ended outpouching through the wall of a tubular organ or bounded cavity.		hp.json		http://purl.obolibrary.org/obo/MPATH_68		
MPATH:66	biolink:NamedThing	dilatation	Increase in the diameter of an orifice or tubular structure beyond its normal dimensions.		hp.json		http://purl.obolibrary.org/obo/MPATH_66		
GO:0090206	biolink:BiologicalProcess	negative regulation of cholesterol metabolic process	Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.		hp.json		http://purl.obolibrary.org/obo/GO_0090206		
PATO:0001450	biolink:NamedThing	edematous	A structural quality which is held by a bearer when the latter exhibits an excessive accumulation of extracellular fluid.		hp.json	oedematous|oedema|edemic|edema|oedemic	http://purl.obolibrary.org/obo/PATO_0001450		value_slim|mpath_slim
GO:0090205	biolink:BiologicalProcess	positive regulation of cholesterol metabolic process	Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.		hp.json		http://purl.obolibrary.org/obo/GO_0090205		
PATO:0001453	biolink:NamedThing	detached from	An attachment quality inhering in a bearer by virtue of the bearer's lacking connection or association with another entity.		hp.json	detached	http://purl.obolibrary.org/obo/PATO_0001453		relational_slim|value_slim|mpath_slim
MPATH:70	biolink:NamedThing	fistula	An abnormal passage between two internal organs or leading from a cavity to the body surface.		hp.json		http://purl.obolibrary.org/obo/MPATH_70		
PATO:0001468	biolink:NamedThing	curved dorsal	A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the back or upper surface of an organism.		hp.json	curved posterior (human torso)|curved superior (human head)	http://purl.obolibrary.org/obo/PATO_0001468		value_slim
MPATH:74	biolink:NamedThing	hamartoma	A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477.		hp.json		http://purl.obolibrary.org/obo/MPATH_74		
PATO:0001469	biolink:NamedThing	curved ventral	A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the abdomen of an organism.		hp.json	curved inferior (human head)|curved anterior (human torso)	http://purl.obolibrary.org/obo/PATO_0001469		value_slim
MPATH:86	biolink:NamedThing	organ specific developmental defect	Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations.		hp.json		http://purl.obolibrary.org/obo/MPATH_86		
PATO:0001477	biolink:NamedThing	retracted	A positional quality inhering in a bearer by virtue of the bearer's being drawn in or pulled back from any given point.		hp.json	retruded|moved	http://purl.obolibrary.org/obo/PATO_0001477		value_slim
MPATH:89	biolink:NamedThing	cardiovascular developmental defect	Abnormal development of the heart or vascular tissue resulting in morphological abnormality.		hp.json		http://purl.obolibrary.org/obo/MPATH_89		
PATO:0001472	biolink:NamedThing	decreased depth	A depth which is relatively low.		hp.json	low depth|shallow	http://purl.obolibrary.org/obo/PATO_0001472		value_slim
PATO:0001470	biolink:NamedThing	proportionality to	A quality inhering in a bearer by virtue of the bearer's magnitude in respect to a related entity.		hp.json	ratio|quotient|rate|proportion|proportionality	http://purl.obolibrary.org/obo/PATO_0001470		relational_slim|attribute_slim
PATO:0001475	biolink:NamedThing	increased position	A position which is relatively high.		hp.json	high position	http://purl.obolibrary.org/obo/PATO_0001475		value_slim
PATO:0001476	biolink:NamedThing	decreased position	A positional which is relatively low.		hp.json	low position	http://purl.obolibrary.org/obo/PATO_0001476		value_slim
PATO:0001473	biolink:NamedThing	duplicated	A quality inhering in a bearer by virtue of the bearer's being present in two copies.		hp.json	doubled	http://purl.obolibrary.org/obo/PATO_0001473		value_slim|mpath_slim
PATO:0001474	biolink:NamedThing	anteverted	An oriented quality inhering in a bearer by virtue of the bearer's axis being positioned forward.		hp.json		http://purl.obolibrary.org/obo/PATO_0001474		value_slim|mpath_slim
MPATH:90	biolink:NamedThing	aneurysm	Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber.		hp.json		http://purl.obolibrary.org/obo/MPATH_90		
PATO:0001488	biolink:NamedThing	cellular motility	A cellular quality inhering in a cell by virtue of whether the bearer exhibits the ability to move spontaneously.		hp.json		http://purl.obolibrary.org/obo/PATO_0001488		scalar_slim|disposition_slim|attribute_slim
MPATH:98	biolink:NamedThing	lymphangiectasis	A stretching and widening of the lymphatic vessels.		hp.json	Lymphectasia|telangiectasia lymphatica	http://purl.obolibrary.org/obo/MPATH_98		
PATO:0001482	biolink:NamedThing	prominent	A quality inhering in a bearer by virtue of the bearer's standing out or projecting beyond a surface or line.		hp.json		http://purl.obolibrary.org/obo/PATO_0001482		value_slim
PATO:0001483	biolink:NamedThing	aplastic	Absence of an organ, tissue or cell due to failure to develop from a primordium or precursor cell.		hp.json	aplasia|undeveloped	http://purl.obolibrary.org/obo/PATO_0001483		value_slim|mpath_slim
PATO:0001481	biolink:NamedThing	sloped	A shape quality inhering in a bearer by virtue of the bearer's having an oblique or slanted direction.		hp.json		http://purl.obolibrary.org/obo/PATO_0001481		value_slim
PATO:0001419	biolink:NamedThing	sharp	A shape quality inhering in a bearer by virtue of the bearer's terminating in a point or edge.		hp.json		http://purl.obolibrary.org/obo/PATO_0001419		value_slim|cell_quality
MPATH:14	biolink:NamedThing	process of degenerative change	A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell.		hp.json		http://purl.obolibrary.org/obo/MPATH_14		
PATO:0001410	biolink:NamedThing	striated	A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel.		hp.json		http://purl.obolibrary.org/obo/PATO_0001410		mpath_slim|cell_quality|value_slim
MPATH:31	biolink:NamedThing	emphysema	Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number.		hp.json		http://purl.obolibrary.org/obo/MPATH_31		
MPATH:34	biolink:NamedThing	amyloid deposition	Extracellular deposition of amyloid protein.		hp.json	Amyloidosis	http://purl.obolibrary.org/obo/MPATH_34		
MPATH:33	biolink:NamedThing	intracellular and extracellular accumulation	Accumulation of substances within, on the surface of or between cells.		hp.json		http://purl.obolibrary.org/obo/MPATH_33		
MPATH:28	biolink:NamedThing	atherosclerosis	Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification.		hp.json		http://purl.obolibrary.org/obo/MPATH_28		
MPATH:27	biolink:NamedThing	arthrosis	Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process.		hp.json	osteoarthrosis|Degenerative joint disease	http://purl.obolibrary.org/obo/MPATH_27		
MPATH:25	biolink:NamedThing	tissue specific degenerative process	Degenerative process characteristic of a particular tissue.		hp.json		http://purl.obolibrary.org/obo/MPATH_25		
CHEBI:4167	biolink:ChemicalSubstance	D-glucopyranose	A glucopyranose having D-configuration.	PMID:19913595|HMDB:HMDB0000122|CAS:2280-44-6|Beilstein:1281604|Reaxys:1281604|PMID:9140037|KEGG:D00009|PMID:17928662|MetaCyc:D-Glucose|KNApSAcK:C00001122|PMID:17336832|PMID:9501190|PMID:7524207|GlyTouCan:G15021LG|PMID:15987845|Gmelin:83256|GlyGen:G15021LG|PMID:9545565|PMID:9506998|PMID:16901854|PMID:17439666|PMID:32619908|KEGG:C00031|Wikipedia:Glucose|PMID:26812026	hp.json	Dextrose|WURCS=2.0/1,1,0/[a2122h-1x_1-5]/1/|D-glucopyranose|glucose|D-Glucose|D-Glcp|Glc-OH|Grape sugar|D-glucose|Glucose|D-Glc	http://purl.obolibrary.org/obo/CHEBI_4167		3_STAR
GO:0090257	biolink:BiologicalProcess	regulation of muscle system process	Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.		hp.json		http://purl.obolibrary.org/obo/GO_0090257		
PATO:0001435	biolink:NamedThing	attachment quality	A structural quality inhering in a bearer by virtue of the bearer's having connection or association with another entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001435		relational_slim|attribute_slim
PATO:0001434	biolink:NamedThing	reproductive quality	An organismal quality inhering in a bearer by virtue of the bearer's ability to produce new life or offspring.		hp.json		http://purl.obolibrary.org/obo/PATO_0001434		
PATO:0001439	biolink:NamedThing	tonicity	A contractile quality inhering in a bearer by virtue of the bearer's elastic tension that facilitate response to stimuli.		hp.json	tone	http://purl.obolibrary.org/obo/PATO_0001439		scalar_slim|disposition_slim|attribute_slim
MPATH:36	biolink:NamedThing	calcium deposition	Intra or extracellular deposition of calcium usually as calcium phosphate.		hp.json		http://purl.obolibrary.org/obo/MPATH_36		
PATO:0001447	biolink:NamedThing	calcified	A composition quality inhering in an bearer by virtue of the bearer's being encrusted or impregnated with calcium carbonate (CHEBI:3311).		hp.json	calcification|calcareous	http://purl.obolibrary.org/obo/PATO_0001447		cell_quality|value_slim|mpath_slim
PATO:0001444	biolink:NamedThing	broken	A structural quality inhering in a bearer by virtue of the bearer's components no longer being in a single contiguous unit.		hp.json	torn|fragmented|hemorrhaged|fractured|split|cracked	http://purl.obolibrary.org/obo/PATO_0001444		value_slim
MPATH:56	biolink:NamedThing	developmental or adult structural  defect	Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult.		hp.json		http://purl.obolibrary.org/obo/MPATH_56		
MPATH:55	biolink:NamedThing	developmental and structural abnormality	Developmental and structural abnormalities occurring during embryonic development or during adult life.		hp.json		http://purl.obolibrary.org/obo/MPATH_55		
PATO:0001449	biolink:NamedThing	cartilaginous	A composition quality inhering in an bearer by virtue of the bearer's cartilage quantities.		hp.json		http://purl.obolibrary.org/obo/PATO_0001449		value_slim|mpath_slim
PATO:0001442	biolink:NamedThing	wholeness	A structural quality inhering in a bearer by virtue of whether the bearer includes all its components.		hp.json		http://purl.obolibrary.org/obo/PATO_0001442		attribute_slim
UBERON:0005192	biolink:AnatomicalEntity	deferent duct artery	An artery in males that provides blood to the vas deferens. The artery usually arises from the anterior trunk of the superior vesical artery. It accompanies the vas deferens into the testis, where it anastomoses with the testicular artery. In this way it also supplies blood to the testis and epididymis. A small branch supplies the ureter[WP].	FMA:18930|MA:0001940|EMAPA:37513	hp.json	artery of ductus deferens|vas deferens artery|arteria ductus deferentis|ductus deferens artery	http://purl.obolibrary.org/obo/UBERON_0005192		human_reference_atlas
OBO:uberon/core#filtered_through	biolink:NamedThing	filtered through	Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity.		hp.json		http://purl.obolibrary.org/obo/uberon/core#filtered_through		
UBERON:0005199	biolink:AnatomicalEntity	cervical mammary gland	A mammary gland that is part of a cervical region.	MA:0000789	hp.json		http://purl.obolibrary.org/obo/UBERON_0005199		
UBERON:0005196	biolink:AnatomicalEntity	spleen germinal center	A germinal center that is part of the spleen. The spleen germinal center is located in a secondary B follicle in the white pulp of the spleen.	MA:0000764|EMAPA:35803|UMLS:C1710156|NCIT:C49760	hp.json	splenic germinal center|spleen GC|spleen follicle center|germinal center of spleen	http://purl.obolibrary.org/obo/UBERON_0005196		pheno_slim|human_reference_atlas
UBERON:0005195	biolink:AnatomicalEntity	deferent duct vein	A vein that is part of a vas deferens [Automatically generated definition].	EMAPA:37514|MA:0002100	hp.json		http://purl.obolibrary.org/obo/UBERON_0005195		
UBERON:0005194	biolink:AnatomicalEntity	thoracic vein	A vein that is part of a thorax [Automatically generated definition].	MA:0002235|SCTID:281472008|NCIT:C53142|UMLS:C0226629|EMAPA:37197	hp.json		http://purl.obolibrary.org/obo/UBERON_0005194		
UBERON:0005193	biolink:AnatomicalEntity	ethmoidal artery	One of: anterior or posterior ethmoidal arteries.	EMAPA:37081|MA:0001949|UMLS:C0226184|NCIT:C52855	hp.json	ethmoid artery	http://purl.obolibrary.org/obo/UBERON_0005193		grouping_class
CHEBI:4194	biolink:ChemicalSubstance	D-hexose	A hexose that has D-configuration at position 5.	KEGG:C00738	hp.json	D-Hexose|D-hexopyranose|D-hexoses|D-hexose	http://purl.obolibrary.org/obo/CHEBI_4194		3_STAR
UBERON:0017163	biolink:AnatomicalEntity	skin bony tubercle	A bony structure embedded in skin, roughly equivalent to osteoderms.		hp.json	bony tubercles|bony tubercle	http://purl.obolibrary.org/obo/UBERON_0017163		
UBERON:5101463	biolink:AnatomicalEntity	manual digit 1 digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit 1 plus the associated metapodial element.		hp.json	manual digit 1 skeleton|manual digit 1|manual digit I digitopodial skeleton	http://purl.obolibrary.org/obo/UBERON_5101463		
UBERON:0005181	biolink:AnatomicalEntity	thoracic segment organ	An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions.	EMAPA:37271|MA:0000563	hp.json	upper body organ	http://purl.obolibrary.org/obo/UBERON_0005181		non_informative
UBERON:0005185	biolink:AnatomicalEntity	renal medulla collecting duct	The portion of the collecting duct that resides in the renal medulla.	BTO:0004536|EMAPA:35459|EMAPA:28061|MA:0002935	hp.json	kidney medulla collecting duct|medullary collecting duct	http://purl.obolibrary.org/obo/UBERON_0005185		
UBERON:0005184	biolink:AnatomicalEntity	hair medulla	Innermost layer of the hair shaft.	EMAPA:35389|BTO:0004671|MA:0000158	hp.json	medulla of hair shaft	http://purl.obolibrary.org/obo/UBERON_0005184		pheno_slim
CHEBI:68485	biolink:ChemicalSubstance	alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp	alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-D-Glcp with beta-configuration at the reducing end anomeric centre.	PMID:31537530|GlyTouCan:G00059MO|PMID:19443021|GlyGen:G00059MO|PMID:25568069	hp.json	alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose|alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc|Galalpha1-4Galbeta1-4Glcbeta|alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose|WURCS=2.0/3,3,2/[a2122h-1b_1-5][a2112h-1b_1-5][a2112h-1a_1-5]/1-2-3/a4-b1_b4-c1|Gala1-4Galb1-4Glcb	http://purl.obolibrary.org/obo/CHEBI_68485		3_STAR
UBERON:0005178	biolink:AnatomicalEntity	thoracic cavity element	An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli.	MA:0000557|EMAPA:37273	hp.json	thoracic cavity organ	http://purl.obolibrary.org/obo/UBERON_0005178		non_informative|pheno_slim
UBERON:0005177	biolink:AnatomicalEntity	trunk region element	An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions.	MA:0000516|EMAPA:37270	hp.json	trunk organ	http://purl.obolibrary.org/obo/UBERON_0005177		non_informative|organ_slim
UBERON:0005176	biolink:AnatomicalEntity	tooth enamel organ	A circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth.	MA:0001604|FMA:312389|ZFA:0005138|MESH:D004658|CALOHA:TS-0271|EMAPA:32888|TAO:0005138|BTO:0001722	hp.json	organum enameleum|enamel organ|dental organ|odontogenic organ	http://purl.obolibrary.org/obo/UBERON_0005176		vertebrate_core|pheno_slim
UBERON:0005175	biolink:AnatomicalEntity	chest organ	An organ that is part of a chest [Automatically generated definition].	EMAPA:37272|MA:0000552	hp.json		http://purl.obolibrary.org/obo/UBERON_0005175		non_informative|organ_slim
UBERON:0005174	biolink:AnatomicalEntity	dorsal region element	An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back.	MA:0001901|EMAPA:37274	hp.json	dorsal region organ|back organ	http://purl.obolibrary.org/obo/UBERON_0005174		non_informative
UBERON:0005173	biolink:AnatomicalEntity	abdominal segment element	An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region.	EMAPA:37062|MA:0000529	hp.json	abdominal segment organ	http://purl.obolibrary.org/obo/UBERON_0005173		non_informative
UBERON:0005172	biolink:AnatomicalEntity	abdomen element	An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland.	MA:0000522|SCTID:272631008	hp.json	abdomen organ	http://purl.obolibrary.org/obo/UBERON_0005172		non_informative
UBERON:0005171	biolink:AnatomicalEntity	hepatic duct	Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion).	EMAPA:16843|OpenCyc:Mx4rvWo8WJwpEbGdrcN5Y29ycA|MA:0000357|NCIT:C32730|EHDAA2:0000741|EHDAA:3049|UMLS:C0917710|VHOG:0000219|FMA:71891|galen:HepaticDuct	hp.json		http://purl.obolibrary.org/obo/UBERON_0005171		vertebrate_core|pheno_slim
UBERON:5101466	biolink:AnatomicalEntity	pedal digit digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of pedal digit plus the associated metapodial element.		hp.json	pedal digit|pedal digit skeleton	http://purl.obolibrary.org/obo/UBERON_5101466		
UBERON:0005179	biolink:AnatomicalEntity	pelvic region element	An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis.	EMAPA:37275|MA:0000543	hp.json	pelvic element|pelvis organ|pelvis region organ	http://purl.obolibrary.org/obo/UBERON_0005179		non_informative|organ_slim|pheno_slim
PATO:0001408	biolink:NamedThing	ciliatedness	A cellular quality inhering in a bearer by virtue of the bearer's having thin, tail-like projections extending outwards from the cell body.		hp.json		http://purl.obolibrary.org/obo/PATO_0001408		value_slim|cell_quality
PATO:0001409	biolink:NamedThing	spindle-shaped	A shape quality inhering in a bearer by virtue of the bearer's resembling a long tapered rod.		hp.json		http://purl.obolibrary.org/obo/PATO_0001409		value_slim|mpath_slim|cell_quality
PATO:0001402	biolink:NamedThing	multipotent	A cellular potency that is the capacity to form multiple differentiated cell types.		hp.json		http://purl.obolibrary.org/obo/PATO_0001402		value_slim|cell_quality|disposition_slim
PATO:0001400	biolink:NamedThing	unipotent	A cellular potency that is the capacity to produce only one differentiated cell type.		hp.json		http://purl.obolibrary.org/obo/PATO_0001400		cell_quality|disposition_slim|value_slim
PATO:0001401	biolink:NamedThing	oligopotent	A cellular potency that is the capacity to form multiple differentiated cell types of a specific lineage and lack self renewing capacity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001401		cell_quality|disposition_slim|value_slim
PATO:0001406	biolink:NamedThing	binucleate	A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei.		hp.json		http://purl.obolibrary.org/obo/PATO_0001406		value_slim|mpath_slim|cell_quality
PATO:0001407	biolink:NamedThing	mononucleate	A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus.		hp.json		http://purl.obolibrary.org/obo/PATO_0001407		value_slim|mpath_slim|cell_quality
PATO:0001404	biolink:NamedThing	nucleate quality	A cellular quality inhering in a bearer by virtue of bearer's number of nuclei.		hp.json		http://purl.obolibrary.org/obo/PATO_0001404		attribute_slim
PATO:0001405	biolink:NamedThing	anucleate	A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus.		hp.json		http://purl.obolibrary.org/obo/PATO_0001405		value_slim|mpath_slim|cell_quality
NCBITaxon:55879	biolink:OrganismalEntity	Rhabditoidea		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_55879		
UBERON:0005162	biolink:AnatomicalEntity	multi cell part structure	A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.	CARO:0001000|FBbt:00007060|FMA:83115|AAO:0011000	hp.json	multi-cell-part structure|cell part cluster|multi-cell-component structure	http://purl.obolibrary.org/obo/UBERON_0005162		upper_level
UBERON:0005160	biolink:AnatomicalEntity	vestigial structure	A remnant structure from earlier development or evolution.		hp.json		http://purl.obolibrary.org/obo/UBERON_0005160		
UBERON:0005169	biolink:AnatomicalEntity	interstitial tissue	Connective tissue between the cellular elements of a structure.	FMA:86301	hp.json	interstitium	http://purl.obolibrary.org/obo/UBERON_0005169		pheno_slim
GO:0043891	biolink:MolecularActivity	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity	Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+.	MetaCyc:GAPDHSYNEC-RXN|EC:1.2.1.59	hp.json	glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)|triosephosphate dehydrogenase (NAD(P)+)|D-glyceraldehyde 3-phosphate:NAD(P)+ oxidoreductase (phosphorylating)|triosephosphate dehydrogenase (NAD(P))|NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase activity	http://purl.obolibrary.org/obo/GO_0043891		
GO:0006826	biolink:BiologicalProcess	iron ion transport	The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	iron transport|ferric ion transport|iron ion import|ferric iron transport|ferric iron import|ferric ion import|ferric iron uptake|ferrous iron transport|ferrous ion transport	http://purl.obolibrary.org/obo/GO_0006826		
GO:0006820	biolink:BiologicalProcess	anion transport	The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0006820		
UBERON:0005233	biolink:AnatomicalEntity	medial-nasal process ectoderm	An ectoderm that is part of a medial nasal prominence [Automatically generated definition].	EMAPA:16809|VHOG:0000803|EHDAA2:0001078|FMA:312675	hp.json		http://purl.obolibrary.org/obo/UBERON_0005233		
HP:0003587	biolink:PhenotypicFeature	Insidious onset	Gradual, very slow onset of disease manifestations.	UMLS:C0332164|SNOMEDCT_US:367326009|UMLS:C1298634|SNOMEDCT_US:61751001	hp.json	Gradual onset	http://purl.obolibrary.org/obo/HP_0003587		
UBERON:0005239	biolink:AnatomicalEntity	basal plate metencephalon		VHOG:0000320|EMAPA:17078|EHDAA2:0001154	hp.json	metencephalon basal plate	http://purl.obolibrary.org/obo/UBERON_0005239		
HP:0003584	biolink:PhenotypicFeature	Late onset	A type of adult onset with onset of symptoms after the age of 60 years.	UMLS:C4025592	hp.json		http://purl.obolibrary.org/obo/HP_0003584		
UBERON:0005236	biolink:AnatomicalEntity	osseus labyrinth vestibule	A small, oval, bony chamber of the labyrinth. The vestibule contains the utricle and saccule, organs which are part of the balancing apparatus of the ear.	VHOG:0001220|UMLS:C0458718|BTO:0003382|XAO:0000199|GAID:881|MESH:D014722|NCIT:C33873|EV:0100366|MA:0001185|CALOHA:TS-0479|FMA:60183	hp.json	vestibule|inner ear vestibule|inner ear vestibulum|vestibular part of bony labyrinth|osseous labyrinth vestibule|bony labyrinth vestibule|vestibulum labyrinthi|vestibule of bony labyrinth|vestibular apparatus|vestibulum auris	http://purl.obolibrary.org/obo/UBERON_0005236		pheno_slim
HP:0003581	biolink:PhenotypicFeature	Adult onset	Onset of disease manifestations in adulthood, defined here as at the age of 16 years or later.	UMLS:C1853562	hp.json	Symptoms begin in adulthood|Onset in early adulthood|Onset in adulthood	http://purl.obolibrary.org/obo/HP_0003581		
UBERON:0005234	biolink:AnatomicalEntity	optic eminence ectoderm	An ectoderm that is part of a optic eminence [Automatically generated definition].	EHDAA:940|RETIRED_EHDAA2:0001309|EMAPA:16539|VHOG:0001105	hp.json		http://purl.obolibrary.org/obo/UBERON_0005234		
GO:0006837	biolink:BiologicalProcess	serotonin transport	The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.		hp.json		http://purl.obolibrary.org/obo/GO_0006837		
GO:0006835	biolink:BiologicalProcess	dicarboxylic acid transport	The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	sodium:dicarboxylate transport	http://purl.obolibrary.org/obo/GO_0006835		
GO:0006833	biolink:NamedThing	water transport			hp.json		http://purl.obolibrary.org/obo/GO_0006833		
CHEBI:32439	biolink:ChemicalSubstance	alaninate	An alpha-amino-acid anion that is the conjugate base of alanine, arising from deprotonation of the carboxy group.	Gmelin:101040|Beilstein:3903719	hp.json	alaninate|2-aminopropanoate|alanine anion	http://purl.obolibrary.org/obo/CHEBI_32439		3_STAR
UBERON:0005222	biolink:AnatomicalEntity	liver left lobe parenchyma	A parenchyma that is part of a left lobe of liver [Automatically generated definition].	FMA:71658|VHOG:0000839|EMAPA:18310|EHDAA2:0001002	hp.json	parenchyma of left lobe of liver	http://purl.obolibrary.org/obo/UBERON_0005222		
UBERON:0005221	biolink:AnatomicalEntity	liver right lobe parenchyma	A parenchyma that is part of a right lobe of liver [Automatically generated definition].	FMA:71657|EHDAA2:0001010|VHOG:0000840|EMAPA:18317	hp.json	parenchyma of right lobe of liver	http://purl.obolibrary.org/obo/UBERON_0005221		
HP:0003596	biolink:PhenotypicFeature	Middle age onset	A type of adult onset with onset of symptoms at the age of 40 to 60 years.	UMLS:C1969363	hp.json		http://purl.obolibrary.org/obo/HP_0003596		
UBERON:0005229	biolink:AnatomicalEntity	lower leg epithelium	An epithelium that is part of a lower leg [Automatically generated definition].	EHDAA2:0001031|EMAPA:17497|VHOG:0001050	hp.json		http://purl.obolibrary.org/obo/UBERON_0005229		
UBERON:0005228	biolink:AnatomicalEntity	upper arm epithelium	An epithelium that is part of a forelimb stylopod [Automatically generated definition].	EMAPA:17425|VHOG:0000990|EHDAA2:0002113	hp.json		http://purl.obolibrary.org/obo/UBERON_0005228		
UBERON:0005227	biolink:AnatomicalEntity	manual digit epithelium	An epithelium that is part of a finger [Automatically generated definition].	EHDAA2:0000406|VHOG:0001032|EMAPA:32647	hp.json	finger epithelium|hand digit epithelium|fore limb digit epithelium	http://purl.obolibrary.org/obo/UBERON_0005227		
UBERON:0005226	biolink:AnatomicalEntity	pedal digit epithelium	An epithelium that is part of a toe [Automatically generated definition].	VHOG:0001031|EMAPA:32946	hp.json	hind limb digit epithelium|toe epithelium|foot digit epithelium	http://purl.obolibrary.org/obo/UBERON_0005226		
UBERON:0005225	biolink:AnatomicalEntity	upper leg epithelium	An epithelium that is part of a hindlimb stylopod [Automatically generated definition].	EMAPA:17500|VHOG:0001041|EHDAA2:0002131	hp.json		http://purl.obolibrary.org/obo/UBERON_0005225		
HP:0003593	biolink:PhenotypicFeature	Infantile onset	Onset of signs or symptoms of disease between 28 days to one year of life.	UMLS:C1848924	hp.json	Infantile onset|Onset in infancy|Onset in first year of life	http://purl.obolibrary.org/obo/HP_0003593		
GO:0006801	biolink:BiologicalProcess	superoxide metabolic process	The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.		hp.json	superoxide free radical metabolism|oxygen free radical metabolic process|oxygen free radical metabolism|superoxide metabolism|superoxide free radical metabolic process	http://purl.obolibrary.org/obo/GO_0006801		
HP:0003566	biolink:PhenotypicFeature	Increased serum prostaglandin E2	An increased concentration of prostaglandin E2 in the blood.	UMLS:C3150358	hp.json	Elevated prostaglandin E2	http://purl.obolibrary.org/obo/HP_0003566		
UBERON:0005211	biolink:AnatomicalEntity	renal medulla interstitium	Tissue surrounding the loop of Henle in the renal medulla.	EMAPA:18326|MA:0002619	hp.json	kidney medulla interstitium|medullary stroma|medullary interstitium|renal medullary interstitial tissue|renal medullary interstitium	http://purl.obolibrary.org/obo/UBERON_0005211		
HP:0003565	biolink:PhenotypicFeature	Elevated erythrocyte sedimentation rate	An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.	UMLS:C0151632|SNOMEDCT_US:165468009	hp.json	Increased erythrocyte sedimentation rate|High erythrocyte sedimentation rate|Elevated sedimentation rate|Elevated ESR|Raised erythrocyte sedimentation rate|High ESR	http://purl.obolibrary.org/obo/HP_0003565		
HP:0003564	biolink:PhenotypicFeature	Folate-dependent fragile site at Xq28	The presence of a folate sensitive fragile site at chromosome Xq28.	UMLS:C1839785	hp.json		http://purl.obolibrary.org/obo/HP_0003564		
HP:0003563	biolink:PhenotypicFeature	Decreased LDL cholesterol concentration	An decreased concentration of low-density lipoprotein cholesterol in the blood.	SNOMEDCT_US:190786004|UMLS:C0853085|UMLS:C0020597|MSH:D006995	hp.json	Hypobetalipoproteinemia|Decreased circulating low-density lipoprotein levels|Decreased LDLc concentration|Decreased LDL	http://purl.obolibrary.org/obo/HP_0003563		
PR:P25918	biolink:Protein	B-lymphocyte antigen CD19 (mouse)	A CD19 molecule that is encoded in the genome of mouse.	UniProtKB:P25918	hp.json	differentiation antigen CD19 (mouse)|mCD19|Cd19|CD19 (mouse)	http://purl.obolibrary.org/obo/PR_P25918		
HP:0003568	biolink:PhenotypicFeature	Decreased glucosephosphate isomerase level	A decreased level of glucose-6-phosphate isomerase.	SNOMEDCT_US:124669001|UMLS:C1291611	hp.json	Glucosephosphate isomerase deficiency|Phosphohexose isomerase deficiency|Decreased glucose phosphate isomerase activity	http://purl.obolibrary.org/obo/HP_0003568		
UBERON:0005219	biolink:AnatomicalEntity	hindbrain subarachnoid space	A subarachnoid space that is part of a hindbrain [Automatically generated definition].	VHOG:0001303|EMAPA:18211	hp.json	subarachnoid space hindbrain|subarachnoid space rhombencephalon	http://purl.obolibrary.org/obo/UBERON_0005219		
UBERON:0005218	biolink:AnatomicalEntity	diencephalon subarachnoid space	A subarachnoid space that is part of a diencephalon [Automatically generated definition].	EMAPA:19053|VHOG:0001302	hp.json	subarachnoid space diencephalon	http://purl.obolibrary.org/obo/UBERON_0005218		
UBERON:0005217	biolink:AnatomicalEntity	midbrain subarachnoid space	A subarachnoid space that is part of a midbrain [Automatically generated definition].	EMAPA:19055|VHOG:0001304	hp.json	subarachnoid space mesencephalon|subarachnoid space midbrain	http://purl.obolibrary.org/obo/UBERON_0005217		
UBERON:0005216	biolink:AnatomicalEntity	optic eminence surface ectoderm	An external ectoderm that is part of a optic eminence [Automatically generated definition].	VHOG:0000520|RETIRED_EHDAA2:0001311|EMAPA:16539	hp.json		http://purl.obolibrary.org/obo/UBERON_0005216		
UBERON:0005215	biolink:AnatomicalEntity	kidney interstitium	The interstitial compartment of the kidney, comprising the extravascular intertubular spaces of the renal parenchyma, with their attendant cellular elements and extracellular substances, bounded on all sides by epithelial and vascular basement membranes.	MA:0002616|NCIT:C33459|FMA:70983|EMAPA:28518	hp.json	renal stroma|kidney interstitium group|renal interstitial tissue|interstitial tissue of kidney|stroma of kidney|renal interstitium	http://purl.obolibrary.org/obo/UBERON_0005215		pheno_slim|human_reference_atlas
GO:0006807	biolink:BiologicalProcess	nitrogen compound metabolic process	The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.		hp.json	nitrogen compound metabolism	http://purl.obolibrary.org/obo/GO_0006807		goslim_metagenomics|goslim_pir
HP:0003562	biolink:PhenotypicFeature	Abnormal metaphyseal vascular invasion		UMLS:C3277127	hp.json		http://purl.obolibrary.org/obo/HP_0003562		
UBERON:0005214	biolink:AnatomicalEntity	inner renal medulla interstitium	A portion of interstitial tissue that is part of a inner medulla of kidney [Automatically generated definition].	MA:0002620|EMAPA:28364	hp.json	kidney inner medulla interstitium|papillary interstitium|inner medullary interstitium	http://purl.obolibrary.org/obo/UBERON_0005214		
HP:0003561	biolink:PhenotypicFeature	Birth length less than 3rd percentile		UMLS:C1855650	hp.json	Birth length < 3rd percentile|Birth length <3rd percentile	http://purl.obolibrary.org/obo/HP_0003561		
HP:0003560	biolink:PhenotypicFeature	Muscular dystrophy	The term dystrophy means abnormal growth. However, muscular dystrophy is used to describe primary myopathies with a genetic basis and a progressive course characterized by progressive skeletal muscle weakness and wasting, defects in muscle proteins, and histological features of muscle fiber degeneration (necrosis) and regeneration. If possible, it is preferred to use other HPO terms to describe the precise phenotypic abnormalities.	UMLS:C0026850|MSH:D009136|SNOMEDCT_US:193225000|SNOMEDCT_US:73297009|UMLS:C1864711	hp.json	Muscle biopsy shows dystrophic changes	http://purl.obolibrary.org/obo/HP_0003560		
UBERON:0005212	biolink:AnatomicalEntity	Leydig cell region of testis	The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS..	MA:0002713|EMAPA:18687	hp.json	interstitium of the testis|testis - interstitial|interstitium of testis|testis interstitial tissue|testis interstitium	http://purl.obolibrary.org/obo/UBERON_0005212		pheno_slim
GO:0006812	biolink:BiologicalProcess	cation transport	The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	di-, tri-valent inorganic cation transport|trivalent inorganic cation transport	http://purl.obolibrary.org/obo/GO_0006812		
GO:0006810	biolink:BiologicalProcess	transport	The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein.		hp.json	solute:solute exchange|small molecule transport|single-organism transport	http://purl.obolibrary.org/obo/GO_0006810		goslim_generic|goslim_candida|prokaryote_subset|gocheck_do_not_annotate|goslim_plant|goslim_pir|goslim_metagenomics|goslim_aspergillus|goslim_chembl
GO:0006811	biolink:BiologicalProcess	ion transport	The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0006811		goslim_yeast|goslim_pir|goslim_drosophila
HP:0003577	biolink:PhenotypicFeature	Congenital onset	A phenotypic abnormality that is present at birth.	UMLS:C2752013|UMLS:C1836142	hp.json	Symptoms present at birth|Onset at birth	http://purl.obolibrary.org/obo/HP_0003577		
UBERON:0005200	biolink:AnatomicalEntity	thoracic mammary gland	A lactiferous gland that is located in the thoracic region/breast.	FMA:62088|EMAPA:36633|MA:0000797|EHDAA:6524|EHDAA2:0001056	hp.json	breast mammary gland|lactiferous gland|mammary gland|anterior mammary gland	http://purl.obolibrary.org/obo/UBERON_0005200		pheno_slim
HP:0003575	biolink:PhenotypicFeature	Increased intracellular sodium	An abnormally increased sodium concentration in the cytosol.	UMLS:C4025593	hp.json	High intracellular Na|Increased intracellular Na+ levels	http://purl.obolibrary.org/obo/HP_0003575		
HP:0003574	biolink:PhenotypicFeature	Positive regitine blocking test	A positive response to the regitine blocking test consisting of a substantial reduction in blood pressure following administration of regitine, indicative of the presence of increased levels of epinephrine and norepinephrine in the circulation, which is seen in pheochromocytoma-associated hypertension.	UMLS:C4025594	hp.json		http://purl.obolibrary.org/obo/HP_0003574		
UBERON:0005208	biolink:AnatomicalEntity	right atrium valve	A valve that is part of a right atrium [Automatically generated definition].	EMAPA:17327|EHDAA2:0000302|MA:0001871	hp.json	right atrium valves|superior vena cava valve|valve of right atrium	http://purl.obolibrary.org/obo/UBERON_0005208		
UBERON:0005207	biolink:AnatomicalEntity	tonsil capsule	A capsule that is part of a tonsil [Automatically generated definition].	MA:0000776|FMA:294647	hp.json		http://purl.obolibrary.org/obo/UBERON_0005207		
UBERON:0005206	biolink:AnatomicalEntity	choroid plexus stroma	Stromal matrix surrounding blood vessels within the choroid plexus.	MA:0000825|EMAPA:36609	hp.json	choroid plexus stromal matrix	http://purl.obolibrary.org/obo/UBERON_0005206		
UBERON:0005205	biolink:AnatomicalEntity	lamina propria of vagina		FMA:19979|MA:0002737|EMAPA:35902	hp.json	vagina stroma	http://purl.obolibrary.org/obo/UBERON_0005205		
UBERON:0005204	biolink:AnatomicalEntity	larynx submucosa gland	A gland that is part of a larynx submucosa [Automatically generated definition].	MA:0002729|EMAPA:35475	hp.json	laryngeal submucosa gland	http://purl.obolibrary.org/obo/UBERON_0005204		organ_slim
HP:0003573	biolink:PhenotypicFeature	Increased total bilirubin	Increased concentration of total (conjugated and unconjugated) bilirubin in the blood.	UMLS:C0741494|SNOMEDCT_US:176271000119108	hp.json	Increased bilirubin|High bili total	http://purl.obolibrary.org/obo/HP_0003573		
UBERON:0005203	biolink:AnatomicalEntity	trachea gland	A tubuloacinar seromucous gland that is located principally in the submucosa of the trachea. Excretory ducts from this gland pass through the lamina propria to the tracheal lumen.	MA:0002937|EMAPA:36574|FMA:7473	hp.json	tubular seromucous gland of trachea|tracheal gland|glandula trachealis	http://purl.obolibrary.org/obo/UBERON_0005203		human_reference_atlas|organ_slim|pheno_slim
HP:0003572	biolink:PhenotypicFeature	Low plasma citrulline	A decreased concentration of citrulline in the blood.	UMLS:C1839532	hp.json		http://purl.obolibrary.org/obo/HP_0003572		
HP:0003571	biolink:PhenotypicFeature	Propionic acidemia	Increased concentration of proprionic acid in the blood circulation.	SNOMEDCT_US:69080001|UMLS:C0268579|MSH:D056693|SNOMEDCT_US:124718009	hp.json		http://purl.obolibrary.org/obo/HP_0003571		
GO:0006817	biolink:BiologicalProcess	phosphate ion transport	The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	phosphate transport	http://purl.obolibrary.org/obo/GO_0006817		
HP:0003570	biolink:PhenotypicFeature	Molybdenum cofactor deficiency	Absence of molybdenum cofactor(2-), a cofactor for enzymes including sulfite oxidase, xanthine oxidoreductase, and aldehyde oxidase.	SNOMEDCT_US:29692004|UMLS:C0268119|MSH:C535811	hp.json		http://purl.obolibrary.org/obo/HP_0003570		
UBERON:0005277	biolink:AnatomicalEntity	dorsal skin of toe	A dorsal skin of digit that is part of a pedal digit.	FMA:37868|FMA:60523	hp.json	skin of dorsal part of toe|subdivision of skin of dorsal part of toe|dorsal toe skin	http://purl.obolibrary.org/obo/UBERON_0005277		
UBERON:0005276	biolink:AnatomicalEntity	dorsal skin of finger	A dorsal skin of digit that is part of a manual digit.	FMA:38320|FMA:60346	hp.json	dorsal finger skin|subdivision of skin of dorsal part of finger|skin of dorsal part of finger	http://purl.obolibrary.org/obo/UBERON_0005276		
UBERON:0005275	biolink:AnatomicalEntity	dorsal skin of digit			hp.json	dorsal digit skin|skin of dorsal part of digit	http://purl.obolibrary.org/obo/UBERON_0005275		
UBERON:0005273	biolink:AnatomicalEntity	nail bed	Region of skin beneath the nail plate[WP].	MA:0002706|VHOG:0001362|EMAPA:35581|EV:0100158	hp.json	nailbed	http://purl.obolibrary.org/obo/UBERON_0005273		pheno_slim
UBERON:0005270	biolink:AnatomicalEntity	renal cortex interstitium	A compartment of the renal cortex situated between basement membranes of epithelia and vessels that contains two contiguous cellular networks in mutual contact, one formed by interstitial fibroblasts, the other by dendritic cells.	MA:0002608|EMAPA:28136	hp.json	renal cortical interstitial tissue|kidney cortex interstitium|cortical stroma	http://purl.obolibrary.org/obo/UBERON_0005270		
UBERON:0005279	biolink:AnatomicalEntity	nail bed of toe	A nail bed that is part of a pedal digit.	FMA:60529	hp.json	nail bed of toe	http://purl.obolibrary.org/obo/UBERON_0005279		
NCBITaxon:55885	biolink:OrganismalEntity	Peloderinae		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_55885		
UBERON:0005278	biolink:AnatomicalEntity	nail bed of finger	A nail bed that is part of a manual digit.	FMA:60348	hp.json	nail bed of finger	http://purl.obolibrary.org/obo/UBERON_0005278		
UBERON:0005269	biolink:AnatomicalEntity	renal cortex vein	Artery that receives blood from the renal cortex[MP, modified].	EMAPA:28152|MA:0002592	hp.json	renal cortex venous system|kidney cortex vein	http://purl.obolibrary.org/obo/UBERON_0005269		pheno_slim
UBERON:0005268	biolink:AnatomicalEntity	renal cortex artery	An artery that supplies the renal cortex.	MA:0002582|EMAPA:28147	hp.json	renal cortex arterial system|renal cortex artery|kidney cortex artery	http://purl.obolibrary.org/obo/UBERON_0005268		pheno_slim
UBERON:0005255	biolink:AnatomicalEntity	pedal digit mesenchyme	Mesenchyme that is part of a developing toe [Automatically generated definition].	EMAPA:32947|VHOG:0000463	hp.json	toe mesenchyme|foot digit mesenchyme|finger ray mesenchyme|hind limb digit mesenchyme|pedal digital ray mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005255		
UBERON:0005254	biolink:AnatomicalEntity	upper leg mesenchyme	Mesenchyme that is part of a developing hindlimb stylopod [Automatically generated definition].	VHOG:0000506|EHDAA2:0002132|EMAPA:17501	hp.json		http://purl.obolibrary.org/obo/UBERON_0005254		
UBERON:0005253	biolink:AnatomicalEntity	head mesenchyme	Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells.	TAO:0000113|EHDAA:179|EMAPA:16098|EMAPA_RETIRED:16269|FMA:76622|VHOG:0000332|ZFA:0000113|EFO:0003492|EHDAA2:0000732	hp.json	cephalic mesenchyme|cranial mesenchyme|desmocranium	http://purl.obolibrary.org/obo/UBERON_0005253		pheno_slim|efo_slim|vertebrate_core
UBERON:0005251	biolink:AnatomicalEntity	yolk sac cavity	An anatomical cavity that is part of a yolk sac [Automatically generated definition].	EMAPA:16055|FMA:63942|VHOG:0000843	hp.json	yolk sac lumen|yolk sac space|cavity of yolk sac	http://purl.obolibrary.org/obo/UBERON_0005251		
UBERON:0005250	biolink:AnatomicalEntity	stomatodeum gland	A gland that is part of a stomodeum.	VHOG:0000658	hp.json	stomatodaeum gland	http://purl.obolibrary.org/obo/UBERON_0005250		organ_slim
UBERON:0005259	biolink:AnatomicalEntity	lower leg mesenchyme	Mesenchyme that is part of a developing lower leg [Automatically generated definition].	EMAPA:17498|EHDAA2:0001032|VHOG:0000752	hp.json		http://purl.obolibrary.org/obo/UBERON_0005259		
UBERON:0005258	biolink:AnatomicalEntity	upper arm mesenchyme	Mesenchyme that is part of a developing forelimb stylopod [Automatically generated definition].	VHOG:0000505|EHDAA2:0002114|EMAPA:17426	hp.json		http://purl.obolibrary.org/obo/UBERON_0005258		
UBERON:0005257	biolink:AnatomicalEntity	manual digit mesenchyme	Mesenchyme that is part of a developing finger [Automatically generated definition].	EMAPA:32645|VHOG:0001416|EHDAA2:0000407	hp.json	finger mesenchyme|hand digit mesenchyme|finger ray mesenchyme|fore limb digit mesenchyme|manual digital ray mesenchyme|anterior limb digital ray mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005257		
UBERON:0005256	biolink:AnatomicalEntity	trunk mesenchyme	Mesenchyme that is part of a developing trunk.	EMAPA:16177|VHOG:0000281|EHDAA:377|ZFA:0000081|EFO:0003485|TAO:0000081|EHDAA2:0002092	hp.json	trunk and cervical mesenchyme	http://purl.obolibrary.org/obo/UBERON_0005256		efo_slim|vertebrate_core
CHEBI:68452	biolink:ChemicalSubstance	azole	Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	Wikipedia:Azole	hp.json	azoles	http://purl.obolibrary.org/obo/CHEBI_68452		3_STAR
UBERON:0005243	biolink:AnatomicalEntity	interventricular septum endocardium	An endocardium that is part of a interventricular septum [Automatically generated definition].	EHDAA2:0000887|EHDAA2:0000886|VHOG:0000615|FMA:83584	hp.json	interventricular septum endocardial tissue|endocardium of interventricular septum	http://purl.obolibrary.org/obo/UBERON_0005243		
UBERON:0005249	biolink:AnatomicalEntity	metanephric renal pelvis	A renal pelvis that is part of a metanephros.	VHOG:0000945	hp.json	metanephros pelvis	http://purl.obolibrary.org/obo/UBERON_0005249		
UBERON:0005248	biolink:AnatomicalEntity	bulbus cordis myocardium	A myocardium that is part of a bulbus cordis [Automatically generated definition].	VHOG:0000609|EMAPA:36488	hp.json	bulbus cordis cardiac muscle	http://purl.obolibrary.org/obo/UBERON_0005248		
GO:0090162	biolink:BiologicalProcess	establishment of epithelial cell polarity	The specification and formation of anisotropic intracellular organization of an epithelial cell.		hp.json		http://purl.obolibrary.org/obo/GO_0090162		
HP:0003508	biolink:PhenotypicFeature	Proportionate short stature	A kind of short stature in which different regions of the body are shortened to a comparable extent.	UMLS:C0878660	hp.json	Short stature, proportionate|Proportionate small stature	http://purl.obolibrary.org/obo/HP_0003508		
UBERON:0007806	biolink:AnatomicalEntity	connecting stalk	A bridge of mesoderm connecting the caudal end of the young embryo with the trophoblastic tissues; the precursor of the umbilical cord.	BTO:0004705|NCIT:C34132|UMLS:C1516792	hp.json		http://purl.obolibrary.org/obo/UBERON_0007806		
UBERON:0007807	biolink:AnatomicalEntity	connecting stalk vasculature	A vasculature that is part of a connecting stalk.	EHDAA2:0000313	hp.json	connecting stalk blood vessel|vasculature of connecting stalk|connecting stalk blood vessels	http://purl.obolibrary.org/obo/UBERON_0007807		
UBERON:0007808	biolink:AnatomicalEntity	adipose tissue of abdominal region	Adipose tissue that is located in the abdominal region. This includes any subcutaneous fat, visceral fat or encapsulated adipose tissue depots.	CALOHA:TS-0002|EFO:0003771	hp.json	abdominal adipose tissue|intra-abdominal fat|abdominal fat	http://purl.obolibrary.org/obo/UBERON_0007808		efo_slim
UBERON:0007811	biolink:AnatomicalEntity	craniocervical region	The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae.	galen:HeadAndNeck|FMA:280881|SCTID:361355005|NCIT:C12418|WikipediaCategory:Head_and_neck|MA:0000006|CALOHA:TS-2356|EV:0100009|UMLS:C0460004	hp.json	cephalic region|cephalic part of animal|head or neck|cephalic area|cephalic region|cephalic part of animal|cephalic area|head and neck	http://purl.obolibrary.org/obo/UBERON_0007811		pheno_slim
UBERON:0007812	biolink:AnatomicalEntity	post-anal tail	A tail that extends from the posterior tip of the organism to the anus, contains muscle and skeleton.	NCIT:C77663|EMAPA:16748|UMLS:C0039259|MA:0000008|ZFA:0001117|TAO:0001117|AAO:0010338|XAO:0003026	hp.json	postanal tail|muscular postanal tail|post-anal fin tail|post-vent region	http://purl.obolibrary.org/obo/UBERON_0007812		pheno_slim|vertebrate_core
HP:0003502	biolink:PhenotypicFeature	Mild short stature	A mild degree of short stature, more than -2 SD but not more than -3 SD from mean corrected for age and sex.	UMLS:C3150077|UMLS:C4020838	hp.json	short stature, mild|Relative short stature	http://purl.obolibrary.org/obo/HP_0003502		
GO:0090166	biolink:BiologicalProcess	Golgi disassembly	A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance.		hp.json		http://purl.obolibrary.org/obo/GO_0090166		
GO:0090168	biolink:BiologicalProcess	Golgi reassembly	The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance.		hp.json		http://purl.obolibrary.org/obo/GO_0090168		
GO:0090170	biolink:BiologicalProcess	regulation of Golgi inheritance	Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0090170		
GO:0090171	biolink:BiologicalProcess	chondrocyte morphogenesis	The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte.		hp.json		http://purl.obolibrary.org/obo/GO_0090171		
HP:0003517	biolink:PhenotypicFeature	Birth length greater than 97th percentile		UMLS:C1839271	hp.json	Fetal overgrowth|Foetal overgrowth	http://purl.obolibrary.org/obo/HP_0003517		
HP:0003510	biolink:PhenotypicFeature	Severe short stature	A severe degree of short stature, more than -4 SD from the mean corrected for age and sex.	UMLS:C0013336|SNOMEDCT_US:237837007|SNOMEDCT_US:237836003|SNOMEDCT_US:422065006|MSH:D004392	hp.json	Proportionate dwarfism|Severe short stature|Short stature, severe|Dwarfism|Short stature, extreme	http://purl.obolibrary.org/obo/HP_0003510		
HP:0003514	biolink:PhenotypicFeature	Deficiency or absence of cytochrome b(-245)		UMLS:C1844390	hp.json	Deficiency or absence of cytochrome b	http://purl.obolibrary.org/obo/HP_0003514		
HP:0003513	biolink:PhenotypicFeature	Reduced ratio of renal calcium clearance to creatinine clearance	A reduction of the ratio of renal calcium clearance to creatinine clearance to below 0.01.	UMLS:C4025605	hp.json	Reduced ration of renal Ca clearance to creatinine clearance|Reduced ration of kidney calcium clearance to creatinine clearance|Reduced ration of renal Ca2+ to creatinine clearance	http://purl.obolibrary.org/obo/HP_0003513		
GO:0090174	biolink:BiologicalProcess	organelle membrane fusion	The joining of two lipid bilayers to form a single organelle membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0090174		
GO:0016234	biolink:CellularComponent	inclusion body	A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.	NIF_Subcellular:sao120573470|Wikipedia:Inclusion_bodies	hp.json	neuronal cytoplasmic inclusion|cellular inclusion	http://purl.obolibrary.org/obo/GO_0016234		
GO:0006887	biolink:BiologicalProcess	exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.	Wikipedia:Exocytosis	hp.json	nonselective vesicle exocytosis|vesicle exocytosis	http://purl.obolibrary.org/obo/GO_0006887		goslim_yeast
GO:0006886	biolink:BiologicalProcess	intracellular protein transport	The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.		hp.json	copper-induced intracellular protein transport	http://purl.obolibrary.org/obo/GO_0006886		goslim_generic
GO:0016202	biolink:BiologicalProcess	regulation of striated muscle tissue development	Any process that modulates the frequency, rate or extent of striated muscle development.		hp.json		http://purl.obolibrary.org/obo/GO_0016202		
HGNC:4458	biolink:Gene	GPI (human)	A protein coding gene GPI in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4458		
GO:0090150	biolink:BiologicalProcess	establishment of protein localization to membrane	The directed movement of a protein to a specific location in a membrane.		hp.json	establishment of protein localisation in membrane|establishment of protein localization in membrane	http://purl.obolibrary.org/obo/GO_0090150		
GO:0006896	biolink:BiologicalProcess	Golgi to vacuole transport	The directed movement of substances from the Golgi to the vacuole.		hp.json	Golgi to vacuole vesicle-mediated transport	http://purl.obolibrary.org/obo/GO_0006896		
GO:0006892	biolink:BiologicalProcess	post-Golgi vesicle-mediated transport	The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.		hp.json	post-Golgi transport	http://purl.obolibrary.org/obo/GO_0006892		
GO:0006893	biolink:BiologicalProcess	Golgi to plasma membrane transport	The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis.		hp.json	Golgi to plasma membrane vesicle-mediated transport	http://purl.obolibrary.org/obo/GO_0006893		
GO:0006869	biolink:BiologicalProcess	lipid transport	The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.		hp.json		http://purl.obolibrary.org/obo/GO_0006869		goslim_pir|goslim_drosophila|goslim_yeast
GO:0006865	biolink:BiologicalProcess	amino acid transport	The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0006865		goslim_pir|goslim_yeast
GO:0006860	biolink:BiologicalProcess	extracellular amino acid transport	The directed extracellular movement of amino acids.		hp.json		http://purl.obolibrary.org/obo/GO_0006860		
HP:0003549	biolink:PhenotypicFeature	Abnormality of connective tissue	Any abnormality of the soft tissues, including both connective tissue (tendons, ligaments, fascia, fibrous tissues, and fat).	UMLS:C4025596	hp.json		http://purl.obolibrary.org/obo/HP_0003549		
HP:0003542	biolink:PhenotypicFeature	Increased serum pyruvate	An increased concentration of pyruvate in the blood.	UMLS:C1849488	hp.json	Increased serum pyruvic acid	http://purl.obolibrary.org/obo/HP_0003542		
HP:0003541	biolink:PhenotypicFeature	Urinary glycosaminoglycan excretion	Excretion of glycosaminoglycan in the urine. Glycosaminoglycans are long unbranched polysaccharides consisting of a repeating disaccharide unit.	UMLS:C4025598	hp.json		http://purl.obolibrary.org/obo/HP_0003541		
HP:0003548	biolink:PhenotypicFeature	Subsarcolemmal accumulations of abnormally shaped mitochondria	An abnormally increased number of mitochondria in the cytoplasma adjacent to the sarcolemma (muscle cell membrane), whereby the mitochondria also possess an abnormal morphology.	UMLS:C4025597	hp.json		http://purl.obolibrary.org/obo/HP_0003548		
HP:0003547	biolink:PhenotypicFeature	Shoulder girdle muscle weakness	The shoulder, or pectoral, girdle is composed of the clavicles and the scapulae. Shoulder-girdle weakness refers to lack of strength of the muscles attaching to these bones, that is, lack of strength of the muscles around the shoulders.	SNOMEDCT_US:249940002|UMLS:C0427063|UMLS:C0748691	hp.json	Shoulder weakness|Muscle weakness, shoulder-girdle|Weak shoulder muscles|Shoulder girdle weakness	http://purl.obolibrary.org/obo/HP_0003547		
HP:0003546	biolink:PhenotypicFeature	Exercise intolerance	A functional motor deficit where individuals whose responses to the challenges of exercise fail to achieve levels considered normal for their age and gender.	SNOMEDCT_US:267044007|UMLS:C0424551	hp.json	Inability to exercise|Low exercise endurance|Decreased ability to exercise|Poor exercise tolerance	http://purl.obolibrary.org/obo/HP_0003546		
PATO:0001374	biolink:NamedThing	ploidy	A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism.		hp.json		http://purl.obolibrary.org/obo/PATO_0001374		attribute_slim
PATO:0001375	biolink:NamedThing	haploid	A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes.		hp.json		http://purl.obolibrary.org/obo/PATO_0001375		cell_quality|value_slim
HP:0003540	biolink:PhenotypicFeature	Impaired platelet aggregation	An impairment in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent.	UMLS:C1855853	hp.json	Platelet aggregation defect|Deficient platelet aggregation|Defective platelet aggregation	http://purl.obolibrary.org/obo/HP_0003540		
GO:0006879	biolink:BiologicalProcess	cellular iron ion homeostasis	Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.		hp.json	iron homeostasis	http://purl.obolibrary.org/obo/GO_0006879		
GO:0006874	biolink:BiologicalProcess	cellular calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.		hp.json	regulation of calcium ion concentration	http://purl.obolibrary.org/obo/GO_0006874		
GO:0006875	biolink:BiologicalProcess	cellular metal ion homeostasis	Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell.		hp.json	cellular heavy metal ion homeostasis	http://purl.obolibrary.org/obo/GO_0006875		
GO:0006873	biolink:BiologicalProcess	cellular ion homeostasis	Any process involved in the maintenance of an internal steady state of ions at the level of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0006873		goslim_yeast
HP:0003555	biolink:PhenotypicFeature	Muscle fiber splitting	Fiber splitting or branching is a common finding in human and rat skeletal muscle pathology. Fiber splitting refers to longitudinal halving of the complete fiber, while branching originates from a regenerating end of a necrotic fiber as invaginations of the sarcolemma. In fiber branching, one end of the fiber remains intact as a single entity, while the other end has several branches.	UMLS:C1836057	hp.json	Muscle fibre splitting|Fibre splitting|Fiber splitting	http://purl.obolibrary.org/obo/HP_0003555		
UBERON:0007842	biolink:AnatomicalEntity	membrane bone	Bone element that arises as a result of intramembranous ossification.	ZFA:0001636|VSAO:0000023|EHDAA2:0003085|TAO:0001645|AEO:0000085|XAO:0004014	hp.json	membrane bones	http://purl.obolibrary.org/obo/UBERON_0007842		
HP:0003554	biolink:PhenotypicFeature	Type 2 muscle fiber atrophy	Atrophy (wasting) affecting primary type 2 muscle fibers. This feature in general can only be observed on muscle biopsy.	UMLS:C1864580	hp.json	Type 2 muscle fibre atrophy|Type 2 fiber atrophy|Type 2 fibre atrophy	http://purl.obolibrary.org/obo/HP_0003554		
HP:0003553	biolink:PhenotypicFeature	obsolete Cellulitis due to immunodeficiency			hp.json		http://purl.obolibrary.org/obo/HP_0003553		
UBERON:0007844	biolink:AnatomicalEntity	cartilage element	Skeletal element that is composed of cartilage tissue and may be permanent or transient.	FMA:55107|CALOHA:TS-0118|EMAPA:32730|AAO:0011130|VSAO:0000000|ZFA:0001501|XAO:0004013	hp.json	cartilage|cartilage organ|cartilaginous element|cartilaginous element|chondrogenic element	http://purl.obolibrary.org/obo/UBERON_0007844		pheno_slim|organ_slim
HP:0003552	biolink:PhenotypicFeature	Muscle stiffness	A condition in which muscles cannot be moved quickly without accompanying pain or spasm.	UMLS:C0221170|SNOMEDCT_US:16046003	hp.json		http://purl.obolibrary.org/obo/HP_0003552		
UBERON:0007845	biolink:AnatomicalEntity	regular connective tissue	Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue.	FMA:20103	hp.json		http://purl.obolibrary.org/obo/UBERON_0007845		
HP:0003559	biolink:PhenotypicFeature	Muscle hyperirritability		UMLS:C1853701	hp.json		http://purl.obolibrary.org/obo/HP_0003559		
UBERON:0007846	biolink:AnatomicalEntity	dense regular connective tissue	Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts).	UMLS:C0225333|XAO:0004030|SCTID:22560007|FMA:64781|Wikipedia:Dense_regular_connective_tissue|VSAO:0000050|NCIT:C33453	hp.json	dense regular collagenous tissue|dense regular collagenous connective tissue|typus regularis (textus connectivus collagenosus compactus)|regular dense connective tissue|dense fibrous connective tissue	http://purl.obolibrary.org/obo/UBERON_0007846		
HP:0003558	biolink:PhenotypicFeature	Viral infection-induced rhabdomyolysis	Rhabdomyolysis induced by a viral infection.	UMLS:C4025595	hp.json		http://purl.obolibrary.org/obo/HP_0003558		
HP:0003557	biolink:PhenotypicFeature	Increased variability in muscle fiber diameter	An abnormally high degree of muscle fiber size variation. This phenotypic feature can be observed upon muscle biopsy.	UMLS:C1843700	hp.json	Increased variation in muscle fibre size|Increased variability in muscle fiber size|Increased variability in muscle fibre size|Increased fiber size variation|Increased variability in muscle fibre diameter|Variation in muscle fiber size|Increased variation in fiber size|Increased variation in muscle fiber size|Variation in muscle fibre size|Increased fibre size variation|Increased variation in fibre size	http://purl.obolibrary.org/obo/HP_0003557		
HP:0003551	biolink:PhenotypicFeature	Difficulty climbing stairs	Reduced ability to climb stairs.	SNOMEDCT_US:282195009|UMLS:C0239067	hp.json	Difficulty walking up stairs	http://purl.obolibrary.org/obo/HP_0003551		
HP:0003550	biolink:PhenotypicFeature	Predominantly lower limb lymphedema	Localized fluid retention and tissue swelling caused by a compromised lymphatic system, affecting mainly the legs.	UMLS:C1835228	hp.json		http://purl.obolibrary.org/obo/HP_0003550		
GO:0090181	biolink:BiologicalProcess	regulation of cholesterol metabolic process	Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.		hp.json		http://purl.obolibrary.org/obo/GO_0090181		
UBERON:0007827	biolink:AnatomicalEntity	external nose	External part of the nose containing the external nares.	NCIT:C32566|EMAPA:37831|FMA:59515|UMLS:C0458561	hp.json	nose	http://purl.obolibrary.org/obo/UBERON_0007827		pheno_slim
HP:0003529	biolink:PhenotypicFeature	Parathormone-independent increased renal tubular calcium reabsorption	An increase in the reabsorption of calcium by the renal tubulus that is not associated with increased parathormone levels.	UMLS:C4025604	hp.json	Parathormone-independent increased renal tubular Ca2+ reabsorption|Parathormone-independent increased renal tubular Ca reabsorption	http://purl.obolibrary.org/obo/HP_0003529		
UBERON:0007828	biolink:AnatomicalEntity	girdle bone/zone	A bone that is part of a appendage girdle region.	MA:0000291|EMAPA:35379	hp.json	girdle bone	http://purl.obolibrary.org/obo/UBERON_0007828		
UBERON:0007829	biolink:AnatomicalEntity	pectoral girdle bone	A bone that is part of a pectoral girdle region.	EMAPA:35669|MA:0000292	hp.json	bone of pectoral girdle	http://purl.obolibrary.org/obo/UBERON_0007829		vertebrate_core
HP:0003528	biolink:PhenotypicFeature	Elevated calcitonin		UMLS:C1868394	hp.json	Elevated calcitonin	http://purl.obolibrary.org/obo/HP_0003528		
HP:0003527	biolink:PhenotypicFeature	Hyperprostaglandinuria	An increased concentration of prostaglandin in the urine.	UMLS:C1866498	hp.json	High urine prostaglandin levels	http://purl.obolibrary.org/obo/HP_0003527		
UBERON:0007830	biolink:AnatomicalEntity	pelvic girdle bone/zone	A bone element or fused bone that is part of pelvic girdle.	NCIT:C33287|MA:0000293|EMAPA:18028|SCTID:426214007|UMLS:C0030786	hp.json	bone of pelvic girdle|pelvic girdle bone	http://purl.obolibrary.org/obo/UBERON_0007830		pheno_slim|vertebrate_core
UBERON:0007831	biolink:AnatomicalEntity	pectoral girdle skeleton	A subdivision of a limb or fin skeleton consisting of bones which connects the upper limb or fin to the axial skeleton on each side. It consists of the clavicle and scapula in humans and, in those species with three bones in the pectoral girdle, the coracoid. Some mammalian species (e.g. the dog and the horse) have only the scapula. In humans, the only joints between the shoulder girdle and axial skeleton are the sternoclavicular joints on each side. No joint exists between each scapula and the rib cage; instead the muscular connection between the two permits relatively great mobility of the shoulder girdle in relation to the pelvic girdle. In those species having only the scapula, no joint exists between the forelimb and the thorax, the only attachment being muscular[WP]. Examples: There are only two instances, right and left pectoral girdle skeletons.	EHDAA2:0001420|ZFA:0000407|XAO:0003063|TAO:0000407|VSAO:0000156|VHOG:0001156|MAT:0000181|NCIT:C33547|EFO:0000946|FMA:24141|MIAA:0000181|AAO:0000754|UMLS:C0427245|AAO:0000422	hp.json	pectoral girdle|cingulum pectorale|scapular girdle|skeletal parts of pectoral girdle|skeleton of pectoral girdle	http://purl.obolibrary.org/obo/UBERON_0007831		efo_slim|vertebrate_core
CHEBI:32440	biolink:ChemicalSubstance	alaninium	An alpha-amino-acid cation that is the conjugate acid of alanine.	Gmelin:362663	hp.json	alanine cation|alaninium|1-carboxyethanaminium	http://purl.obolibrary.org/obo/CHEBI_32440		3_STAR
HP:0003521	biolink:PhenotypicFeature	Disproportionate short-trunk short stature	A type of disproportionate short stature characterized by a short trunk but a average-sized limbs.	UMLS:C1846435	hp.json	Disproportionate short-trunked short stature|Disproportionate short-trunked dwarfism|Short-trunked dwarfism	http://purl.obolibrary.org/obo/HP_0003521		
UBERON:0007832	biolink:AnatomicalEntity	pelvic girdle skeleton	Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature.	VHOG:0000305|EHDAA:7149|XAO:0003064|EHDAA:8324|galen:PelvicGirdle|VSAO:0000155|MAT:0000182|EFO:0000947|EMAPA:18028|ZFA:0000565|FMA:87592|AAO:0000768|EHDAA2:0001426|MIAA:0000182|AAO:0000426|TAO:0000565|Wikipedia:Pelvis|http://people.eku.edu/ritchisong/pectoralgirdles.gif	hp.json	pelvic girdle skeleton|skeleton of pelvic girdle|skeletal parts of pelvic girdle|pelvic girdle|skeleton of pelvic girdle|skeletal parts of pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0007832		efo_slim|vertebrate_core
PATO:0001393	biolink:NamedThing	euploid	A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes.		hp.json		http://purl.obolibrary.org/obo/PATO_0001393		cell_quality|value_slim
HP:0003526	biolink:PhenotypicFeature	Orotic acid crystalluria	Formation of crystals owing to an increased concentration of orotic acid in the urine.	UMLS:C3278626	hp.json		http://purl.obolibrary.org/obo/HP_0003526		
HP:0003524	biolink:PhenotypicFeature	Decreased methionine synthase activity	A reduction in methionine synthase activity.	UMLS:C1848580	hp.json	Methionine synthase activity decreased|Decreased activity of methionine synthase|Reduced methionine synthase activity|Methionine synthase deficiency	http://purl.obolibrary.org/obo/HP_0003524		
PATO:0001396	biolink:NamedThing	cellular quality	A monadic quality of continuant that exists at the cellular level of organisation.		hp.json		http://purl.obolibrary.org/obo/PATO_0001396		
PATO:0001397	biolink:NamedThing	cellular potency	A cellular quality that arises by virtue of whether the bearer's disposition to differentiate into one or more mature cell types.		hp.json		http://purl.obolibrary.org/obo/PATO_0001397		disposition_slim|attribute_slim
GO:0006858	biolink:BiologicalProcess	extracellular transport	The transport of substances that occurs outside cells.		hp.json		http://purl.obolibrary.org/obo/GO_0006858		
CHEBI:32458	biolink:ChemicalSubstance	cysteinium		Gmelin:325859	hp.json	1-carboxy-2-mercaptoethanaminium|1-carboxy-2-sulfanylethanaminium|cysteinium|H2cys(+)|cysteine cation	http://purl.obolibrary.org/obo/CHEBI_32458		3_STAR
HP:0003538	biolink:PhenotypicFeature	Increased iduronate sulfatase level	An increased level of iduronate-2-sulfatase activity in the blood.	UMLS:C4025599|UMLS:C2673363	hp.json	Increased serum iduronate sulfatase level|Increased serum iduronate sulfatase	http://purl.obolibrary.org/obo/HP_0003538		
HP:0003533	biolink:PhenotypicFeature	Reduced acetaldehyde dehydrogenase level	Decreased level of acetaldehyde dehydrogenase (ALDH). ALDH and alcohol dehydrogenase (ADH) are the primary enzymes involved in alcohol metabolism.	UMLS:C4025601	hp.json	Delayed oxidation of acetaldehyde	http://purl.obolibrary.org/obo/HP_0003533		
HP:0003532	biolink:PhenotypicFeature	Ornithinuria	An increased concentration of ornithine in the urine.	UMLS:C4025602	hp.json		http://purl.obolibrary.org/obo/HP_0003532		
HP:0003530	biolink:PhenotypicFeature	Elevated circulating glutaric acid concentration	An increased concentration of glutaric acid in the blood.	UMLS:C4025603	hp.json	Glutaric acidemia|Glutarate acidemia	http://purl.obolibrary.org/obo/HP_0003530		
UBERON:0007823	biolink:AnatomicalEntity	appendage girdle region	An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).	EMAPA:37854|VSAO:0000303|FMA:24874	hp.json	fin girdle region|girdle region|fin girdle|limb girdle|limb girdle region|girdle	http://purl.obolibrary.org/obo/UBERON_0007823		
HP:0003537	biolink:PhenotypicFeature	Hypouricemia	An abnormally low level of uric acid in the blood.	UMLS:C0221333|SNOMEDCT_US:4519003	hp.json	Low blood uric acid levels	http://purl.obolibrary.org/obo/HP_0003537		
HP:0003536	biolink:PhenotypicFeature	Decreased fumarate hydratase activity	An abnormality of Krebs cycle metabolism that is characterized by a decreased rate of fumarate hydratase activity.	UMLS:C1853903	hp.json		http://purl.obolibrary.org/obo/HP_0003536		
CHEBI:32456	biolink:ChemicalSubstance	cysteinate(1-)	A sulfur-containing amino-acid anion that is the conjugate base of cysteine, obtained by deprotonation of the carboxy group.	Gmelin:363235|Beilstein:4128885|Reaxys:4128885	hp.json	cysteine monoanion|cysteinate(1-)|2-amino-3-mercaptopropanoate|cys(-)|2-amino-3-sulfanylpropanoate|hydrogen cysteinate	http://purl.obolibrary.org/obo/CHEBI_32456		3_STAR
HP:0003535	biolink:PhenotypicFeature	3-Methylglutaconic aciduria	An increased amount of 3-methylglutaconic acid in the urine.	MSH:C579867|UMLS:C3696376|SNOMEDCT_US:237950009	hp.json	3-Methylglutaconicaciduria	http://purl.obolibrary.org/obo/HP_0003535		
CHEBI:32457	biolink:ChemicalSubstance	cysteinate(2-)		Gmelin:49990	hp.json	cysteinate(2-)|cysteine dianion|2-amino-3-sulfidopropanoate|cysteinate	http://purl.obolibrary.org/obo/CHEBI_32457		3_STAR
HP:0003534	biolink:PhenotypicFeature	Reduced xanthine dehydrogenase level	An abnormal reduction in xanthine dehydrogenase level.	SNOMEDCT_US:124147007|UMLS:C4025600|UMLS:C0268118|MSH:C562584|SNOMEDCT_US:72682008	hp.json	Xanthine dehydrogenase deficiency	http://purl.obolibrary.org/obo/HP_0003534		
UBERON:0007826	biolink:AnatomicalEntity	peritoneal mesentery	Mesentery that is located in the peritoneum.	TAO:0005129|XAO:0000138|FMA:20570|ZFA:0005129	hp.json		http://purl.obolibrary.org/obo/UBERON_0007826		
UBERON:0001309	biolink:AnatomicalEntity	internal iliac artery	The internal iliac artery (formerly known as the hypogastric artery) is the main artery of the pelvis. [WP,unvetted].	NCIT:C32845|MA:0001974|EMAPA:17860|FMA:18808|UMLS:C0226364|BTO:0004667|galen:InternalIliacArtery	hp.json	arteria iliaca interna|hypogastric artery	http://purl.obolibrary.org/obo/UBERON_0001309		uberon_slim|human_reference_atlas
UBERON:0001308	biolink:AnatomicalEntity	external iliac artery	The external iliac artery is a large artery in the pelvic region that carries blood to the lower limb. The external iliac artery is a paired artery, meaning there is one on each side of the body: a right external iliac artery and left external iliac artery. The external iliac artery is accompanied by the external iliac vein, which is located posterior to the artery. [WP,unvetted].	EMAPA:17614|NCIT:C32558|MA:0001973|EHDAA:4337|OpenCyc:Mx4rvkh47pwpEbGdrcN5Y29ycA|EHDAA2:0000463|galen:ExternalIliacArtery|FMA:18805|BTO:0004666|UMLS:C0226398	hp.json	arteria iliaca externa	http://purl.obolibrary.org/obo/UBERON_0001308		uberon_slim|human_reference_atlas
HP:0005092	biolink:PhenotypicFeature	Streaky metaphyseal sclerosis	The presence of streaks (bands) of abnormally increased density of metaphyseal bone.	UMLS:C4025253	hp.json	Streak increase in bone density in wide portion of wide bone	http://purl.obolibrary.org/obo/HP_0005092		
HP:0005093	biolink:PhenotypicFeature	Absent proximal radial epiphyses	Absence of the proximal radial epiphysis.	UMLS:C1855301	hp.json		http://purl.obolibrary.org/obo/HP_0005093		
HP:0030050	biolink:PhenotypicFeature	Narcolepsy	An abnormal phenomenon characterized by a classic tetrad of excessive daytime sleepiness with irresistible sleep attacks, cataplexy (sudden bilateral loss of muscle tone), hypnagogic hallucination, and sleep paralysis.	MSH:D009290|UMLS:C0027404|SNOMEDCT_US:60380001	hp.json		http://purl.obolibrary.org/obo/HP_0030050		
UBERON:0003968	biolink:AnatomicalEntity	peripheral lymph node	The lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes.	EMAPA:37938	hp.json		http://purl.obolibrary.org/obo/UBERON_0003968		pheno_slim
UBERON:0001304	biolink:AnatomicalEntity	germinal epithelium of ovary	Layer of simple cuboidal cells covering surface of ovary[WP].	MA:0001711|EMAPA:17963|BTO:0004483|RETIRED_EHDAA2:0001361|UMLS:C0227875|NCIT:C61518|FMA:18629|EHDAA:8126|VHOG:0000630	hp.json	germinal epithelium (female)|ovarian surface epithelium|ovary germinal epithelium|female coelomic epithelium|surface epithelium of ovary|ovary surface epithelium|epithelium superficiale (ovarium)	http://purl.obolibrary.org/obo/UBERON_0001304		
UBERON:0001307	biolink:AnatomicalEntity	capsule of ovary	A capsule that surrounds a female gonad.	NCIT:C49265|UMLS:C0227877|FMA:18662|EMAPA:35626|MA:0001706	hp.json	ovary capsule|ovarian capsule	http://purl.obolibrary.org/obo/UBERON_0001307		pheno_slim
HP:0005090	biolink:PhenotypicFeature	Lateral femoral bowing	A lateral bending or abnormal curvature of the femur.	UMLS:C1866737	hp.json		http://purl.obolibrary.org/obo/HP_0005090		
UBERON:0003967	biolink:AnatomicalEntity	cutaneous elastic tissue	The slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity.	EMAPA:37841	hp.json	cutaneous elastic fiber|dermal elastic fiber	http://purl.obolibrary.org/obo/UBERON_0003967		pheno_slim
NCBITaxon:33090	biolink:OrganismalEntity	Viridiplantae		GC_ID:1|PMID:16248873|PMID:30257078	hp.json	Chlorobionta|chlorophyte/embryophyte group|Chloroplastida|green plants|Chlorophyta/Embryophyta group|green plants	http://purl.obolibrary.org/obo/NCBITaxon_33090		
HP:0030055	biolink:PhenotypicFeature	Hyperconvex toenail	When viewed on end (with the tip of the toe pointing toward the examiner's eye) the curve of the toenail forms a tighter curve of convexity.	UMLS:C4022661	hp.json		http://purl.obolibrary.org/obo/HP_0030055		
HP:0030056	biolink:PhenotypicFeature	Uncombable hair	Hair that is disorderly, stands out from the scalp, and cannot be combed flat.	UMLS:C1860607	hp.json	Uncombable hair	http://purl.obolibrary.org/obo/HP_0030056		
HP:0030057	biolink:PhenotypicFeature	Autoimmune antibody positivity	The presence of an antibody in the blood circulation that is directed against the organism's own cells or tissues.	UMLS:C4022660	hp.json		http://purl.obolibrary.org/obo/HP_0030057		
HP:0030058	biolink:PhenotypicFeature	Sickled erythrocytes	An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains).	UMLS:C2237347	hp.json		http://purl.obolibrary.org/obo/HP_0030058		
HP:0030051	biolink:PhenotypicFeature	Tip-toe gait	An abnormal gait pattern characterized by the failure of the heel to contact the floor at the onset of stance during gait.	UMLS:C1843570	hp.json	Walking on tiptoes|Toe walking|Tiptoe gait	http://purl.obolibrary.org/obo/HP_0030051		
HP:0030052	biolink:PhenotypicFeature	Inguinal freckling	The presence in the inguinal region (groin) of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin.	UMLS:C1834297	hp.json	Freckles in groin region	http://purl.obolibrary.org/obo/HP_0030052		
HP:0030053	biolink:PhenotypicFeature	Stiff skin	An induration (hardening) of the skin	UMLS:C3276815	hp.json	Indurated skin|Stiff skin	http://purl.obolibrary.org/obo/HP_0030053		
HP:0030054	biolink:PhenotypicFeature	Perifollicular fibrosis	Presence of excess fibrous connective tissue surrounding hair follicules.	UMLS:C2748531	hp.json		http://purl.obolibrary.org/obo/HP_0030054		
HP:0030059	biolink:PhenotypicFeature	Mitochondrial depletion	An abnormal reduction in mitochondrial DNA content of cells.	UMLS:C4022659	hp.json		http://purl.obolibrary.org/obo/HP_0030059		
UBERON:0001312	biolink:AnatomicalEntity	superior vesical artery	An artery that supplies blood to the upper urinary bladder.	NCIT:C52686|UMLS:C0226376|FMA:18839|EMAPA:37123|MA:0002080	hp.json	arteria vesicali superior|arteriae vesicales superiores|arteria vesicalis superior	http://purl.obolibrary.org/obo/UBERON_0001312		human_reference_atlas|uberon_slim
UBERON:0003975	biolink:AnatomicalEntity	internal female genitalia	The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina.	FMA:45654|SCTID:303518005|BTO:0003099	hp.json	female internal genitalia|internal female genital organ|organa genitalia feminina interna|internal genitalia of female reproductive system	http://purl.obolibrary.org/obo/UBERON_0003975		organ_slim|pheno_slim
HP:0005089	biolink:PhenotypicFeature	Abnormal metaphyseal trabeculation	An abnormality of the pattern of trabecula (small interconnecting rods of bone) in a metaphyseal region of bone.	UMLS:C1857139	hp.json		http://purl.obolibrary.org/obo/HP_0005089		
HP:0005084	biolink:PhenotypicFeature	Anterior radial head dislocation	A dislocation of the head of the radius from its socket in the elbow joint in an anterior direction.	UMLS:C2674451	hp.json	Anterior dislocation of radial head	http://purl.obolibrary.org/obo/HP_0005084		
HP:0005085	biolink:PhenotypicFeature	Limited knee flexion/extension	A limited ability of the knee joint to perform extension and flexion.	UMLS:C1968606	hp.json		http://purl.obolibrary.org/obo/HP_0005085		
UBERON:0001310	biolink:AnatomicalEntity	umbilical artery	The umbilical artery is a paired artery (with one for each half of the body) that is found in the abdominal and pelvic regions. In the fetus, it extends into the umbilical cord. [WP,unvetted].	OpenCyc:Mx4rCWdhMGWbEd2AAABQjYGu0g|CALOHA:TS-1077|EMAPA:16331|EHDAA:1026|MESH:D014469|EHDAA:410|EMAPA:16372|BTO:0000841|UMLS:C0041632|GAID:516|NCIT:C33827|MA:0002072|RETIRED_EHDAA2:0002106|FMA:18820	hp.json	a. umbilicalis	http://purl.obolibrary.org/obo/UBERON_0001310		pheno_slim|human_reference_atlas|uberon_slim
HP:0005086	biolink:PhenotypicFeature	Knee osteoarthritis		MSH:D020370|UMLS:C0409959|SNOMEDCT_US:239873007	hp.json		http://purl.obolibrary.org/obo/HP_0005086		
UBERON:0003970	biolink:AnatomicalEntity	placental labyrinth vasculature	Blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate.		hp.json	placental labyrinth vascular network|placental vasculature|vasculature of placenta labyrinth	http://purl.obolibrary.org/obo/UBERON_0003970		pheno_slim
UBERON:0003959	biolink:AnatomicalEntity	rete testis	An anastomosing network of delicate tubules located in the hilum of the testicle (mediastinum testis) that carries sperm from the seminiferous tubules to the vasa efferentia[WP].	MESH:D012152|FMA:19834|GAID:399|NCIT:C33467|EMAPA:18332|MA:0003013|UMLS:C0035278	hp.json	Haller's rete	http://purl.obolibrary.org/obo/UBERON_0003959		pheno_slim
HP:0030060	biolink:PhenotypicFeature	Nervous tissue neoplasm	A neoplasm derived from nervous tissue (not necessarily a neoplasm located in the nervous system).	MSH:D009380|UMLS:C0027665	hp.json		http://purl.obolibrary.org/obo/HP_0030060		
HP:0030061	biolink:PhenotypicFeature	Neuroectodermal neoplasm	A neoplasm arising in the neuroectoderm, the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems, including some glial cells.	SNOMEDCT_US:73676002|MSH:D017599|UMLS:C0206093|SNOMEDCT_US:253096008	hp.json		http://purl.obolibrary.org/obo/HP_0030061		
NCBITaxon:33083	biolink:OrganismalEntity	Dictyostelia		PMID:11062127|PMID:9342353|GC_ID:1|PMID:29367151	hp.json	cellular slime molds|dictyostelid cellular slime molds|Dictyostelids|Dictyostelida|Dictyosteliida	http://purl.obolibrary.org/obo/NCBITaxon_33083		
UBERON:0003955	biolink:AnatomicalEntity	molar crown	The part of a molar that is covered by enamel.	EMAPA:37910|FMA:85301	hp.json	molar tooth tooth crown|crown of molar tooth|tooth crown of molar tooth|molar tooth crown	http://purl.obolibrary.org/obo/UBERON_0003955		pheno_slim
UBERON:0003956	biolink:AnatomicalEntity	aqueous drainage system	The structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins.	EMAPA:37427	hp.json		http://purl.obolibrary.org/obo/UBERON_0003956		pheno_slim
HP:0030066	biolink:PhenotypicFeature	Ependymoblastoma	A highly malignant embryonal tumor of infancy and young childhood characterized by neuroectodermal elements organized in distinctive multilayered rosettes. Ependymoblastomas are large lesions that occur in the supratentorial compartment, typically displaying a physical connection to the ventricular system.	SNOMEDCT_US:715901002|SNOMEDCT_US:21589007|UMLS:C0700367|MSH:D018242	hp.json		http://purl.obolibrary.org/obo/HP_0030066		
HP:0030067	biolink:PhenotypicFeature	Peripheral primitive neuroectodermal neoplasm	A primitive neuroectodermal neoplasm that occurs extracranially in soft tissue and bone.	MSH:D018241|SNOMEDCT_US:73676002|UMLS:C0684337|SNOMEDCT_US:703707001|SNOMEDCT_US:253096008	hp.json		http://purl.obolibrary.org/obo/HP_0030067		
HP:0030068	biolink:PhenotypicFeature	Olfactory esthesioneuroblastoma	A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate.	SNOMEDCT_US:68614005|SNOMEDCT_US:422886007|SNOMEDCT_US:76060004|UMLS:C0206717|MSH:D018304	hp.json		http://purl.obolibrary.org/obo/HP_0030068		
HP:0030069	biolink:PhenotypicFeature	Primary central nervous system lymphoma	A form of extranodal, high-grade non-Hodgkin B-cell neoplasm, usually large cell or immunoblastic type that originates in the brain, leptomeninges, spinal cord, or eyes and typically remains confined to the CNS.	SNOMEDCT_US:307649006|UMLS:C0280803|SNOMEDCT_US:21964009	hp.json	Primary CNS lymphoma	http://purl.obolibrary.org/obo/HP_0030069		
HP:0030062	biolink:PhenotypicFeature	Craniopharyngioma	A benign pituitary-region neoplasm that originates from Rathke's pouch. Craniopharyngiomas are benign slow growing tumours that are located within the sellar and para sellar region of the central nervous system.	SNOMEDCT_US:189179009|SNOMEDCT_US:40009002|MSH:D003397|UMLS:C0010276	hp.json		http://purl.obolibrary.org/obo/HP_0030062		
HP:0030063	biolink:PhenotypicFeature	Neuroepithelial neoplasm	A neoplasm composed of neural epithelium, not necessarily a neoplasm located in the neural epithelium or neuroepithelium.	UMLS:C0206715|MSH:D018302	hp.json		http://purl.obolibrary.org/obo/HP_0030063		
HP:0030064	biolink:PhenotypicFeature	Neurocytoma	A benign brain tumor composed of neural elements which most often arise from the septum pellucidum and the walls of the lateral ventricles.	MSH:D018306|SNOMEDCT_US:128858006|UMLS:C1622510	hp.json		http://purl.obolibrary.org/obo/HP_0030064		
HP:0030065	biolink:PhenotypicFeature	Primitive neuroectodermal tumor	A tumor that originates in cells from the primitive neural crest. This group of tumors is characteirzed by the presence of primitive cells with elements of neuronal and/or glial differentiation.	UMLS:C0206663|SNOMEDCT_US:699028006|SNOMEDCT_US:39781001|SNOMEDCT_US:55045006|MSH:D018242	hp.json	Primitive neuroectodermal tumour	http://purl.obolibrary.org/obo/HP_0030065		
CHEBI:58123	biolink:ChemicalSubstance	(2S)-2-hydroxy monocarboxylic acid anion	A hydroxy monocarboxylic acid anion where the hydroxy group is placed at position 2 (alpha to the carboxy group) and has (S)-stereochemistry; major species at pH 7.3.	PMID:10850983	hp.json	(2S)-2-hydroxy monocarboxylic acid anions|(2S)-alpha-hydroxy monocarboxylic acid anion|(2S)-2-hydroxy monocarboxylates|(S)-2-hydroxyacid anions|a (2S)-2-hydroxycarboxylate|(S)-2-hydroxyacid anion|(2S)-2-hydroxycarboxylate|(2S)-2-hydroxy monocarboxylate|(2S)-alpha-hydroxy monocarboxylic acid anions	http://purl.obolibrary.org/obo/CHEBI_58123		3_STAR
UBERON:0001301	biolink:AnatomicalEntity	epididymis	The elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens.	VHOG:0001265|MIAA:0000130|NCIT:C12328|BTO:0000408|galen:Epididymis|CALOHA:TS-0285|GAID:397|MESH:D004822|MA:0000397|FMA:18255|EV:0100103|UMLS:C0014533|EFO:0000982|MAT:0000130|EMAPA:19290	hp.json		http://purl.obolibrary.org/obo/UBERON_0001301		uberon_slim|pheno_slim|efo_slim
HP:0005099	biolink:PhenotypicFeature	obsolete Severe hydrops fetalis			hp.json	Severe hydrops	http://purl.obolibrary.org/obo/HP_0005099		
UBERON:0001300	biolink:AnatomicalEntity	scrotum	The external sac of skin that encloses the testes. It is an extension of the abdomen, and in placentals is located between the penis and anus.	galen:Scrotum|BTO:0003098|CALOHA:TS-2341|MESH:D012611|NCIT:C12785|UMLS:C0036471|FMA:18252|GAID:393|EMAPA:19296|OpenCyc:Mx4rwUC_upwpEbGdrcN5Y29ycA|MA:0000409	hp.json		http://purl.obolibrary.org/obo/UBERON_0001300		pheno_slim|uberon_slim
UBERON:0001303	biolink:AnatomicalEntity	left uterine tube	A fallopian tube that is part of a left side of organism [Automatically generated definition].	UMLS:C0227902|SCTID:280107002|FMA:18484|EMAPA:37368|MA:0001716|NCIT:C32959	hp.json	left fallopian tube|left oviduct	http://purl.obolibrary.org/obo/UBERON_0001303		
UBERON:0001302	biolink:AnatomicalEntity	right uterine tube	A fallopian tube that is part of a right side of organism [Automatically generated definition].	SCTID:280106006|UMLS:C0227900|NCIT:C33475|EMAPA:37369|FMA:18483|MA:0001717	hp.json	right oviduct|right fallopian tube	http://purl.obolibrary.org/obo/UBERON_0001302		
UBERON:0003963	biolink:AnatomicalEntity	otic ganglion	The ganglion that supplies nerve fibers to the parotid gland.	EMAPA:36274|BAMS:GoIX|EHDAA2:0001335|FMA:6967|EHDAA:6706	hp.json	ganglion oticum|Arnold's ganglion|otic parasympathetic ganglion	http://purl.obolibrary.org/obo/UBERON_0003963		pheno_slim
UBERON:0003960	biolink:AnatomicalEntity	styloid process of temporal bone	Slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments.	EMAPA:36320|FMA:52877	hp.json	temporal styloid process|processus styloideus|styloid process|processus styloideus ossis temporalis|styloid process of petrous part of temporal bone|processus styloideus ossis temporalis	http://purl.obolibrary.org/obo/UBERON_0003960		pheno_slim
CHEBI:58126	biolink:ChemicalSubstance	porphobilinogen(1-)	Conjugate base of porphobilinogen arising from deprotonation of the two carboxy groups and protonation of the amino group; major species at pH 7.3.		hp.json	3-[5-(azaniumylmethyl)-4-(carboxylatomethyl)-1H-pyrrol-3-yl]propanoate|porphobilinogen|porphobilinogen anion	http://purl.obolibrary.org/obo/CHEBI_58126		3_STAR
HP:0005096	biolink:PhenotypicFeature	Distal femoral bowing	A bending or abnormal curvature of the distal portion of the femur.	UMLS:C1860107	hp.json		http://purl.obolibrary.org/obo/HP_0005096		
HP:0005070	biolink:PhenotypicFeature	Proximal radial head dislocation	A dislocation of the head of the radius from its socket in the elbow joint in an proximal direction.	UMLS:C1865570	hp.json		http://purl.obolibrary.org/obo/HP_0005070		
HP:0030070	biolink:PhenotypicFeature	Central primitive neuroectodermal tumor	A primitive neuroectodermal neoplasm that occurs in the central nervous system.	SNOMEDCT_US:39781001|UMLS:C3887678	hp.json	Central primitive neuroectodermal tumour	http://purl.obolibrary.org/obo/HP_0030070		
HP:0030071	biolink:PhenotypicFeature	Medulloepithelioma	A primitive neuroectodermal tumor that originates from the cells of the embryonic medullary canal.	SNOMEDCT_US:715903004|SNOMEDCT_US:39005004|UMLS:C0334596|MSH:D018242	hp.json		http://purl.obolibrary.org/obo/HP_0030071		
HP:0005072	biolink:PhenotypicFeature	Hyperextensibility at wrists	The ability of the wrist joints to move beyond their normal range of motion.	UMLS:C1850853	hp.json	Increased laxity of wrists|Increased wrist mobility	http://purl.obolibrary.org/obo/HP_0005072		
HP:0030072	biolink:PhenotypicFeature	Paranasal sinus neoplasm	A tumor that originates in the paranasal sinus.	MSH:D010255|UMLS:C0030470|NCIT:C3262|SNOMEDCT_US:126675008	hp.json	Tumour of the paranasal sinuses|Neoplasm of the paranasal sinuses|Tumor of the paranasal sinuses	http://purl.obolibrary.org/obo/HP_0030072		
UBERON:0003946	biolink:AnatomicalEntity	placenta labyrinth	The placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood.		hp.json	labyrinthine layer of placenta|placental labyrinth|labyrinthine layer	http://purl.obolibrary.org/obo/UBERON_0003946		pheno_slim
UBERON:0003947	biolink:AnatomicalEntity	brain ventricle/choroid plexus	The brain ventricles or their associated choroid plexuses.		hp.json		http://purl.obolibrary.org/obo/UBERON_0003947		pheno_slim
HP:0030077	biolink:PhenotypicFeature	Bronchial neoplasm	A tumor originating in a bronchus.	UMLS:C0006264|MSH:D001984|SNOMEDCT_US:126705004|NCIT:C3262	hp.json		http://purl.obolibrary.org/obo/HP_0030077		
HP:0030078	biolink:PhenotypicFeature	Lung adenocarcinoma		MSH:C538231|UMLS:C0152013|NCIT:C2852|SNOMEDCT_US:254626006	hp.json		http://purl.obolibrary.org/obo/HP_0030078		
CHEBI:22160	biolink:ChemicalSubstance	acetamides	Compounds with the general formula RNHC(=O)CH3.		hp.json		http://purl.obolibrary.org/obo/CHEBI_22160		3_STAR
HP:0030079	biolink:PhenotypicFeature	Cervix cancer	A tumor of the uterine cervix.	UMLS:C4048328|SNOMEDCT_US:363354003|MSH:D002583|NCIT:C3262	hp.json		http://purl.obolibrary.org/obo/HP_0030079		
HP:0030073	biolink:PhenotypicFeature	obsolete Pharyngeal neoplasm			hp.json		http://purl.obolibrary.org/obo/HP_0030073		
HP:0030074	biolink:PhenotypicFeature	Chemodectoma	A usually benign neoplasm originating in the chemoreceptor tissue of the carotid body, glomus jugulare, glomus tympanicum, aortic bodies, or the female genital tract.	MSH:D002345|SNOMEDCT_US:127028003|UMLS:C0007279|SNOMEDCT_US:30699005	hp.json	Chemodectomas	http://purl.obolibrary.org/obo/HP_0030074		
HP:0030075	biolink:PhenotypicFeature	Ductal carcinoma in situ	Presence of abnormal cells inside a milk duct, that is, non-invasive breast cancer. Ductal carcinoma in situ is considered to be a precursor lesion to invasive breast cancer.	SNOMEDCT_US:86616005|MSH:D002285|SNOMEDCT_US:373176000|UMLS:C0007124|SNOMEDCT_US:278053004|SNOMEDCT_US:109889007	hp.json		http://purl.obolibrary.org/obo/HP_0030075		
HP:0030076	biolink:PhenotypicFeature	Lobular carcinoma in situ		SNOMEDCT_US:109888004|MSH:D000071960|UMLS:C0279563	hp.json		http://purl.obolibrary.org/obo/HP_0030076		
UBERON:0003953	biolink:AnatomicalEntity	posterior stroma of cornea	The posterior segment of the lamellated connective tissue layer of the cornea.	EMAPA:37415	hp.json	cornea posterior stroma|posterior stroma	http://purl.obolibrary.org/obo/UBERON_0003953		pheno_slim
HP:0005066	biolink:PhenotypicFeature	Cone-shaped epiphyses fused within their metaphyses		UMLS:C4025255	hp.json	Cone-shaped end part of long bone fused within their wide portion of wide bone	http://purl.obolibrary.org/obo/HP_0005066		
UBERON:0003954	biolink:AnatomicalEntity	squamoparietal suture	The articulation of the squamous portion of the temporal bones with the parietal bones[MP]. The squamosal suture arches backward from the pterion and connects the temporal squama with the lower border of the parietal: this suture is continuous behind with the short, nearly horizontal parietomastoid suture, which unites the mastoid process of the temporal with the region of the mastoid angle of the parietal[WP].	EMAPA:19228|FMA:52946	hp.json	squamosal suture|squamoparietal suture of skull|squamous suture|sutura squamosa cranii|squamo-parietal suture|squamous suture of skull	http://purl.obolibrary.org/obo/UBERON_0003954		pheno_slim
HP:0005067	biolink:PhenotypicFeature	Proximal fibular overgrowth	Overgrowth of the proximal part of the fibula.	UMLS:C2673395	hp.json	Overgrowth of innermost part of calf bone	http://purl.obolibrary.org/obo/HP_0005067		
UBERON:0003951	biolink:AnatomicalEntity	ocular fundus	The posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope.	EMAPA:37916|RETIRED_EHDAA2:0000583|GAID:908|galen:FundusOculi|NCIT:C13378|MESH:D005654|UMLS:C0740422	hp.json	eye fundus|fundus oculi|fundus|fundus of eye	http://purl.obolibrary.org/obo/UBERON_0003951		pheno_slim
HP:0005068	biolink:PhenotypicFeature	Absent styloid process of ulna		UMLS:C4025254	hp.json		http://purl.obolibrary.org/obo/HP_0005068		
UBERON:0003952	biolink:AnatomicalEntity	anterior stroma of cornea	The anterior segment of the lamellated connective tissue layer of the cornea.	EMAPA:37414	hp.json	anterior stroma|cornea anterior stroma	http://purl.obolibrary.org/obo/UBERON_0003952		pheno_slim|human_reference_atlas
HP:0005069	biolink:PhenotypicFeature	Rhizo-meso-acromelic limb shortening		UMLS:C2673654	hp.json		http://purl.obolibrary.org/obo/HP_0005069		
HP:0005063	biolink:PhenotypicFeature	Fragmented, irregular epiphyses		UMLS:C1867494	hp.json	Fragmented, irregular end part of bone	http://purl.obolibrary.org/obo/HP_0005063		
HP:0030080	biolink:PhenotypicFeature	Burkitt lymphoma	A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass.	SNOMEDCT_US:397400006|SNOMEDCT_US:77381001|UMLS:C0006413|MSH:D002051|SNOMEDCT_US:118617000|SNOMEDCT_US:277571004|SNOMEDCT_US:22197008	hp.json		http://purl.obolibrary.org/obo/HP_0030080		
HP:0030081	biolink:PhenotypicFeature	Punctate periventricular T2 hyperintense foci	Multiple pointlike areas of high T2 signal observed upon magnetic resonance imaging of the periventricular cerebral white matter.	UMLS:C4022658	hp.json		http://purl.obolibrary.org/obo/HP_0030081		
UBERON:0003937	biolink:AnatomicalEntity	reproductive gland	Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction.	MA:0001751	hp.json	gland of genitalia|reproductive system gland|reproductive gland|genitalia gland|sex gland|gland of reproductive system	http://purl.obolibrary.org/obo/UBERON_0003937		organ_slim|pheno_slim
HP:0030082	biolink:PhenotypicFeature	Abnormal drinking behavior	Abnormal consumption of fluids with excessive or insufficient consumption of fluid or any other abnormal pattern of fluid consumption.	UMLS:C4022657	hp.json	Abnormal drinking behaviour|Abnormal drinking behavior	http://purl.obolibrary.org/obo/HP_0030082		
HP:0030083	biolink:PhenotypicFeature	Salt craving	An excessive desire to eat salt (sodium chloride) or salty foods.	UMLS:C0240928	hp.json	Salt craving	http://purl.obolibrary.org/obo/HP_0030083		
UBERON:0003933	biolink:AnatomicalEntity	cranial cartilage	A cartilage element that is part of the cranial skeleton.	ZFA:0001458|TAO:0001458	hp.json	cranium cartilage|cartilage of cranium|cranial cartilages	http://purl.obolibrary.org/obo/UBERON_0003933		
HP:0030088	biolink:PhenotypicFeature	Increased serum testosterone level	An elevated circulating testosterone level in the blood.	UMLS:C0241358|UMLS:C4072885	hp.json	Increased testosterone|High serum testosterone levels|Increased serum testosterone levels|High serum testosterone level	http://purl.obolibrary.org/obo/HP_0030088		
HP:0030089	biolink:PhenotypicFeature	Abnormal muscle fiber protein expression	An anomalous amount of protein present in or on the surface of muscle fibers. This feature may be appreciate upon immunohistochemical investigation of muscle biopsy tissue.	UMLS:C4022653	hp.json	Abnormal muscle fibre protein expression	http://purl.obolibrary.org/obo/HP_0030089		
HP:0030084	biolink:PhenotypicFeature	Clinodactyly	An angulation of a digit at an interphalangeal joint in the plane of the palm (finger) or sole (toe).	SNOMEDCT_US:17268007|UMLS:C0265610|UMLS:C4280304	hp.json	Permanent curving of the finger|Curvature of digit	http://purl.obolibrary.org/obo/HP_0030084		
HP:0030085	biolink:PhenotypicFeature	Abnormal CSF lactate concentration	Abnormal concentration of lactate in the cerebrospinal fluid.	UMLS:C4022656	hp.json	Abnormal CSF lactate level	http://purl.obolibrary.org/obo/HP_0030085		
HP:0030086	biolink:PhenotypicFeature	Reduced CSF lactate	Decreased concentration of lactate in the cerebrospinal fluid.	UMLS:C4022655	hp.json	Hypolactatorachia	http://purl.obolibrary.org/obo/HP_0030086		
HP:0030087	biolink:PhenotypicFeature	Abnormal circulating testosterone concentration	An anomalous concentration of testosterone in the blood.	UMLS:C0580454|SNOMEDCT_US:166458009|UMLS:C4022654	hp.json	Abnormal serum testosterone level|Abnormal testosterone level	http://purl.obolibrary.org/obo/HP_0030087		
UBERON:0015917	biolink:AnatomicalEntity	superficial lymph node	A lymph node that is located close to the surface.	FMA:12767|NCIT:C102716	hp.json		http://purl.obolibrary.org/obo/UBERON_0015917		
UBERON:0015918	biolink:AnatomicalEntity	deep lymph node	A lymph node that is located deeper within the organism, further from the surface.	FMA:12768	hp.json		http://purl.obolibrary.org/obo/UBERON_0015918		
UBERON:0003942	biolink:AnatomicalEntity	somatic sensory system	The sensory system for the sense of touch and pain.	Wikipedia:Somatosensory_system|EMAPA:37954|NLXANAT:090818|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2887	hp.json	somatic sensory system|system for detection of somatic senses|somatosensory system	http://purl.obolibrary.org/obo/UBERON_0003942		pheno_slim
HP:0030011	biolink:PhenotypicFeature	Imperforate hymen	A congenital disorder where the hymen (a membrane that surrounds or partially covers the external vaginal opening) does not have an opening and completely obstructs the vagina.	MSH:C562397|SNOMEDCT_US:65937002|UMLS:C0152436	hp.json		http://purl.obolibrary.org/obo/HP_0030011		
HP:0032674	biolink:PhenotypicFeature	Cutaneous wound	A cutaneous wound is a defined as a disruption of normal anatomic structure and function of the skin that occured owing to an injury of the skin. Wound healing is a dynamic, interactive processinvolving soluble mediators, blood cells, extracellularmatrix, and parenchymal cells. Wound healing has three phases: inflammation, tissue formation, and tissue remodeling, that overlap in time.		hp.json	Skin wound	http://purl.obolibrary.org/obo/HP_0032674		
HP:0032673	biolink:PhenotypicFeature	Focal non-convulsive status epilepticus without coma	Focal non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically focal. It is a prolonged focal non-motor seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032673		
HP:0030012	biolink:PhenotypicFeature	Abnormal female reproductive system physiology		UMLS:C4020714|UMLS:C4022678	hp.json	Abnormal female reproductive system physiology|Abnormal female genital system physiology	http://purl.obolibrary.org/obo/HP_0030012		
HP:0032676	biolink:PhenotypicFeature	Chronic cutaneous wound	A cutaneous wound that has failed to proceed through the orderly and timely process to produce an atomic and functional integrity, or proceeded through the repair process without establishing a sustained anatomic and functional result.		hp.json	Chronic nonhealing cutaneous wound	http://purl.obolibrary.org/obo/HP_0032676		
HP:0030013	biolink:PhenotypicFeature	obsolete Endometriosis			hp.json		http://purl.obolibrary.org/obo/HP_0030013		
HP:0032675	biolink:PhenotypicFeature	Acute cutaneous wound	A cutaneous wound that is proceeding through an orderly and timely reparative process that results in sustained restoration of the anatomic and functional integrity of the skin.		hp.json		http://purl.obolibrary.org/obo/HP_0032675		
HP:0030014	biolink:PhenotypicFeature	Female sexual dysfunction	A problem occurring during any phase of the female sexual response cycle that prevents the individual from experiencing satisfaction from the sexual activity	UMLS:C1112442	hp.json		http://purl.obolibrary.org/obo/HP_0030014		
HP:0032670	biolink:PhenotypicFeature	Tonic status epilepticus	Tonic status epilepticus is a type of status epilepticus characterized by focal or bilateral limb stiffening or elevation, which may be electrographically generalized or focal.		hp.json		http://purl.obolibrary.org/obo/HP_0032670		
PATO:0001778	biolink:NamedThing	increased strength	A strength which is relatively high.		hp.json	high strength	http://purl.obolibrary.org/obo/PATO_0001778		value_slim
HP:0032672	biolink:PhenotypicFeature	Autonomic status epilepticus	Autonomic status epilepticus is a type of non-convulsive status epilepticus without coma with prominent autonomic features regardless of whether it is electrographically generalized or focal.		hp.json		http://purl.obolibrary.org/obo/HP_0032672		
PATO:0001779	biolink:NamedThing	decreased strength	A strength which is relatively low.		hp.json	weak	http://purl.obolibrary.org/obo/PATO_0001779		value_slim
HP:0030010	biolink:PhenotypicFeature	Hydrometrocolpos	Hydrometrocolpos is an accumulation of uterine and vaginal secretions as well as menstrual blood in the uterus and vagina.	SNOMEDCT_US:60023006|UMLS:C0269209	hp.json		http://purl.obolibrary.org/obo/HP_0030010		
HP:0032671	biolink:PhenotypicFeature	Non-convulsive status epilepticus without coma	A type of status epilepticus without prominent motor symptoms in the absence of coma.		hp.json		http://purl.obolibrary.org/obo/HP_0032671		
HP:0030019	biolink:PhenotypicFeature	Increased female libido	Elevated sexual desire in female	UMLS:C4022675	hp.json	Increased female sex drive	http://purl.obolibrary.org/obo/HP_0030019		
UBERON:0001350	biolink:AnatomicalEntity	coccyx	A collection of caudal vertebrae in the coccygeal region that are fused and part of the bony pelvis.	GAID:239|MESH:D003050|EHDAA2:0000259|UMLS:C0009194|FMA:20229|galen:Coccyx|AAO:0000731|NCIT:C12696|OpenCyc:Mx4rv1XqHJwpEbGdrcN5Y29ycA	hp.json	fused caudal vertebral column|os coccygis|fused caudal vertebrae|tailbone|os coccygis|coccygeal skeleton|coccyx [coccygeal vertebrae I-IV]|coccyx [vertebrae coccygeae I-IV]|coccygeal vertebrae I-IV	http://purl.obolibrary.org/obo/UBERON_0001350		uberon_slim|organ_slim|pheno_slim
HP:0030015	biolink:PhenotypicFeature	Female anorgasmia	The persistent of recurrent difficulty, delay in, or absence of attaining orgasm following sufficient sexual stimulation and arousal.	UMLS:C0033948|SNOMEDCT_US:60103007|UMLS:C4022677	hp.json	Female orgasmic disorder	http://purl.obolibrary.org/obo/HP_0030015		
HP:0032678	biolink:PhenotypicFeature	Eyelid myoclonia seizure	An eyelid myoclonia seizure is a type of generalized myoclonic seizure which may or may not be associated with loss of awareness.		hp.json		http://purl.obolibrary.org/obo/HP_0032678		
HP:0032677	biolink:PhenotypicFeature	Generalized-onset motor seizure	A generalized motor seizure is a type of generalized-onset seizure with predominantly motor (involving musculature) signs. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement.		hp.json	Generalized onset motor seizure|Generalised-onset motor seizure|Generalised onset motor seizure	http://purl.obolibrary.org/obo/HP_0032677		
HP:0030016	biolink:PhenotypicFeature	Dyspareunia	Recurrent or persistent genital pain associated with sexual intercourse.	UMLS:C1384606|SNOMEDCT_US:71315007|MSH:D004414	hp.json		http://purl.obolibrary.org/obo/HP_0030016		
HP:0030017	biolink:PhenotypicFeature	Vaginismus	Recurrent or persistent involuntary spasms of the musculature of the outer third of the vagina that interferes with vaginal penetration, and which causes personal distress.	MSH:D052065|UMLS:C2004487|SNOMEDCT_US:79012001	hp.json	Pelvic floor myalgia|Myalgia of pelvic floor	http://purl.obolibrary.org/obo/HP_0030017		
HP:0030018	biolink:PhenotypicFeature	Decreased female libido	Dminished sexual desire in female.	UMLS:C4022676	hp.json	Decreased female sex drive	http://purl.obolibrary.org/obo/HP_0030018		
HP:0032679	biolink:PhenotypicFeature	Focal non-motor seizure	A type of focal-onset seizure characterized by non-motor signs or symptoms (or behaviour arrest) as its initial semiological manifestation.		hp.json	Focal seizure without motor onset|Partial seizure without motor onset	http://purl.obolibrary.org/obo/HP_0032679		
UBERON:0001356	biolink:AnatomicalEntity	medial circumflex femoral artery	The medial circumflex femoral artery (internal circumflex artery, medial femoral circumflex artery) is an artery in the upper thigh that helps supply blood to the neck of the femur. [WP,unvetted].	FMA:20799|EMAPA:37670|MA:0001996	hp.json	medial femoral circumflex artery|arteria circumflexa femoris medialis	http://purl.obolibrary.org/obo/UBERON_0001356		human_reference_atlas|uberon_slim
UBERON:0001355	biolink:AnatomicalEntity	deep femoral artery	The profunda femoris artery (also known as the deep femoral artery, or the deep artery of the thigh) is a branch of the femoral artery that, as its name suggests, travels more deeply (posteriorly) than the rest of the femoral artery. [WP,unvetted].	FMA:20741|NCIT:C32436|MA:0002027|UMLS:C0226455|EMAPA:37216	hp.json	arteria profunda femoris|profunda femoris artery	http://purl.obolibrary.org/obo/UBERON_0001355		human_reference_atlas|uberon_slim
UBERON:0001352	biolink:AnatomicalEntity	external acoustic meatus	A tube running from the outer ear to the middle ear. The human ear canal extends from the pinna to the eardrum and is about 26 mm in length and 7 mm in diameter.	MA:0000260|EHDAA2:0000460|UMLS:C0013444|GAID:864|EMAPA:17588|galen:ExternalAuditoryMeatus|FMA:61734|EV:0100356|VHOG:0000977|NCIT:C12498|MESH:D004424|EHDAA:8975|OpenCyc:Mx4rvli-nZwpEbGdrcN5Y29ycA	hp.json	external auditory tube|auditory canal|auditory meatus|external auditory meatus|ear canal|external acoustic tube|external auditory canal	http://purl.obolibrary.org/obo/UBERON_0001352		pheno_slim|uberon_slim
UBERON:0001351	biolink:AnatomicalEntity	lacrimal sac	The upper dilated end of the nasolacrimal duct that is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla; it connects the lacrimal canaliculi, which drain tears from the eye's surface, and the nasolacrimal duct, which conveys this fluid into the nasal cavity; like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue.	UMLS:C0229289|FMA:20289|NCIT:C32909|MA:0001298	hp.json	lacrymal sac|saccus lacrimalis|lachrymal sac	http://purl.obolibrary.org/obo/UBERON_0001351		uberon_slim|pheno_slim
UBERON:0001353	biolink:AnatomicalEntity	anal region	The anus and surrounding regions. Encompasses both internal and external regions, where present.	EHDAA2:0000122|SCTID:362680001|MA:0000329|MAT:0000042|UMLS:C0230120|EMAPA:16831|MIAA:0000042|VHOG:0000395|EFO:0000847|EHDAA:2931|WBbt:0006919|NCIT:C32069	hp.json	posterior end of organism|posterior	http://purl.obolibrary.org/obo/UBERON_0001353		pheno_slim|efo_slim|uberon_slim
UBERON:0001338	biolink:AnatomicalEntity	urethral gland	Any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine.	FMA:19683|EMAPA:37784|MA:0001688	hp.json	urethra gland (male or female)|urethra gland|urethral mucuous gland|gland of urethra	http://purl.obolibrary.org/obo/UBERON_0001338		organ_slim|pheno_slim|uberon_slim
UBERON:0003999	biolink:AnatomicalEntity	hyoid bone body	The main curve of the hyoid bone, from which the horns extend.	FMA:59495|MA:0002958|EMAPA:18653	hp.json	base of hyoid bone|basihyal bone|basihyoid bone|body of hyoid|corpus ossis hyoidei|hyoid bone base|body of hyoid bone	http://purl.obolibrary.org/obo/UBERON_0003999		pheno_slim
HP:0032685	biolink:PhenotypicFeature	Focal cognitive seizure with auditory agnosia	A focal cognitive seizure characterized by auditory agnosia as the initial semiological manifestation. For example a person may hear a ringing sound, but may not connect this with the concept that the sound is from a telephone ringing.		hp.json		http://purl.obolibrary.org/obo/HP_0032685		
HP:0030022	biolink:PhenotypicFeature	Question mark ear	Cleft between the helix and the lobe.	UMLS:C3888103	hp.json	Cosman ear|Question mark ears|Question mark ear|Constricted ear	http://purl.obolibrary.org/obo/HP_0030022		
PATO:0001787	biolink:NamedThing	rotational curvature	A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis.		hp.json		http://purl.obolibrary.org/obo/PATO_0001787		value_slim
PATO:0001788	biolink:NamedThing	increased mass density	A density which is higher relative to the normal or average.		hp.json	high density	http://purl.obolibrary.org/obo/PATO_0001788		value_slim
HP:0032684	biolink:PhenotypicFeature	Focal aware cognitive seizure with auditory agnosia	A focal cognitive seizure with auditory agnosia characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032684		
HP:0030023	biolink:PhenotypicFeature	Quelprud nodule	Small cartilaginous prominence on the posterior concha.	UMLS:C4022673	hp.json		http://purl.obolibrary.org/obo/HP_0030023		
PATO:0001785	biolink:NamedThing	splayed	A curvature quality inhering in a bearer by virtue of the bearer's being curved outward.		hp.json		http://purl.obolibrary.org/obo/PATO_0001785		value_slim|cell_quality
HP:0030024	biolink:PhenotypicFeature	Pretragal ectopia	Variably shaped, cartilage-containing tissue anterior to the external auditory meatus.	UMLS:C0266609|SNOMEDCT_US:204245004	hp.json	Accessory Tragus|Pretragal Duplication|Extra cartilage in front of the ear	http://purl.obolibrary.org/obo/HP_0030024		
HP:0032687	biolink:PhenotypicFeature	Focal cognitive seizure with memory impairment	A focal cognitive seizure characterized by transient memory impairment as the initial semiological manifestation whilst other cognitive functions and awareness are preserved at seizure onset. The memory impairment may be an inability to recall events occurring prior to the seizure (retrograde amnesia), or failure to encode new memories for events occurring during the seizure (anterograde amnesia).		hp.json	Amnestic aura|Amnestic seizure	http://purl.obolibrary.org/obo/HP_0032687		
PATO:0001786	biolink:NamedThing	split	A shape quality inhering in a bearer by virtue of the bearer's being divided or broken up into parts or divisions.		hp.json	clefted|subdivided|divided|septate|forked	http://purl.obolibrary.org/obo/PATO_0001786		value_slim|mpath_slim
HP:0030025	biolink:PhenotypicFeature	Auricular pit	Small indentation in the lower part of the ascending helix, concha, or in the crus helix.	UMLS:C4022672	hp.json		http://purl.obolibrary.org/obo/HP_0030025		
HP:0032686	biolink:PhenotypicFeature	Focal aware cognitive seizure with memory impairment	A focal cognitive seizure with memory impairment characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032686		
HP:0032681	biolink:PhenotypicFeature	Focal aware cognitive seizure	A focal aware cognitive seizure during which awareness is retained throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032681		
HP:0032680	biolink:PhenotypicFeature	Focal cognitive seizure	A focal cognitive seizure involves an alteration in a cognitive function (which can be a deficit or a positive phenomenon such as forced thought), which occurs at seizure onset. To be classified as a focal cognitive seizure, the change in cognitive function should be specific and out of proportion to other relatively unimpaired aspects of cognition, because all cognition is impaired in a focal impaired awareness seizure.		hp.json	Partial cognitive seizure|Cognitive seizure|Cognitive aura	http://purl.obolibrary.org/obo/HP_0032680		
HP:0032683	biolink:PhenotypicFeature	obsolete Focal aware cognitive seizure with impaired attention			hp.json		http://purl.obolibrary.org/obo/HP_0032683		
HP:0030021	biolink:PhenotypicFeature	Auricular tag	Small protrusion within the pinna.	UMLS:C4022674	hp.json		http://purl.obolibrary.org/obo/HP_0030021		
HP:0032682	biolink:PhenotypicFeature	Focal aware non-motor seizure	A focal non-motor seizure in which awareness is retained throughout the seizure.		hp.json	Focal non-motor aware seizure	http://purl.obolibrary.org/obo/HP_0032682		
PATO:0001780	biolink:NamedThing	dystrophic	A size quality inhering in a bearer by virtue of the bearer's being abnormally developed, usually due to malnutrition.		hp.json	dystrophied|dystrophy	http://purl.obolibrary.org/obo/PATO_0001780		mpath_slim|value_slim
PR:000010228	biolink:Protein	myelin basic protein	A protein that is a translation product of the human MBP gene or a 1:1 ortholog thereof.		hp.json	myelin membrane encephalitogenic protein|MBP|myelin A1 protein|Shi	http://purl.obolibrary.org/obo/PR_000010228		
PATO:0001783	biolink:NamedThing	decreased intensity	An intensity which is relatively low.		hp.json	low intensity	http://purl.obolibrary.org/obo/PATO_0001783		value_slim
HP:0032689	biolink:PhenotypicFeature	Focal cognitive seizure with dissociation	A focal cognitive seizure characterized by an experience of being disconnected from, though aware of, self or environment as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032689		
HP:0030026	biolink:PhenotypicFeature	Squared superior portion of helix	Flattening instead of curving or rounded superior helix, allowing the superior helix to run more horizontally than usual.	UMLS:C4022671	hp.json		http://purl.obolibrary.org/obo/HP_0030026		
HP:0030027	biolink:PhenotypicFeature	Abnormality of the nasal cartilage	A morphological anomaly of the nasal cartilage.	UMLS:C4022670	hp.json	Anomaly of cartilage of nose|Anomaly of nasal cartilage|Malformation of cartilage of nose|Deformity of cartilage of nose|Deformity of nasal cartilage|Malformation of nasal cartilage|Abnormality of cartilage of nose|Abnormality of the nasal cartilage	http://purl.obolibrary.org/obo/HP_0030027		
PATO:0001784	biolink:NamedThing	bifurcated	A branched quality inhering in a bearer by virtue of the bearer's being divided into two branches.		hp.json	forked|bifid	http://purl.obolibrary.org/obo/PATO_0001784		value_slim|mpath_slim|cell_quality
HP:0032688	biolink:PhenotypicFeature	Focal aware cognitive seizure with dissociation	A focal cognitive seizure with dissociation characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032688		
HP:0030028	biolink:PhenotypicFeature	Absent nasal cartilage	Lack of a palpable nasal cartilage.	UMLS:C4022669|UMLS:C4082198|SNOMEDCT_US:232381002|MSH:C562753	hp.json	Failure of development of nasal cartilage|Absent cartilage of nose|Absent nasal cartilage|Missing cartilage of nose|Missing nasal cartilage|Agenesis of cartilage of nose|Agenesis of nasal cartilage|Failure of development of cartilage of nose	http://purl.obolibrary.org/obo/HP_0030028		
HP:0030029	biolink:PhenotypicFeature	Splayed fingers	Divergence of digits along the A/P axis (in the plane of the palm).	UMLS:C4021057	hp.json	Spreading of the fingers|Splayed fingers	http://purl.obolibrary.org/obo/HP_0030029		
PATO:0001782	biolink:NamedThing	increased intensity	An intensity which is relatively high.		hp.json	high intensity	http://purl.obolibrary.org/obo/PATO_0001782		value_slim
UBERON:0001344	biolink:AnatomicalEntity	epithelium of vagina	The epithelial layer of the vagina.	BTO:0000422|NCIT:C49313|UMLS:C0920840|EMAPA:30991|CALOHA:TS-1325|FMA:19978|MA:0001730	hp.json	vagina epithelial tissue|vagina epithelium|epithelium, vaginal|epithelial tissue of vagina|vaginal epithelium	http://purl.obolibrary.org/obo/UBERON_0001344		pheno_slim
UBERON:0001343	biolink:AnatomicalEntity	seminiferous tubule of testis	The tubules in the testes where spermatogenesis occurs.	XAO:0003088|AAO:0010399|NCIT:C13047|BTO:0001235|MESH:D012671|EMAPA:31476|CALOHA:TS-1239|UMLS:C0036630|FMA:19825|NCIT:C34293|EV:0100380|MA:0000412|GAID:400|VHOG:0001363|MAT:0000503|EMAPA:18685|EFO:0001404|UMLS:C1519236	hp.json	seminiferous tubule|testis - seminiferous tubule|tubuli seminiferi|seminiferous cord|tubuli seminiferi	http://purl.obolibrary.org/obo/UBERON_0001343		pheno_slim|efo_slim|uberon_slim
HP:0032690	biolink:PhenotypicFeature	Focal aware cognitive seizure with dyscalculia/acalculia	A focal cognitive seizure with dyscalculia and or acalculia characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032690		
UBERON:0003988	biolink:AnatomicalEntity	thymus corticomedullary boundary	The dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells.	EMAPA:37974	hp.json	thymic cortico-medullary boundary|thymic corticomedullary junction|thymus cortico-medullary boundary|thymus corticomedullary zone|thymus CMZ|thymic corticomedullary zone|thymic corticomedullary boundary|thymus corticomedullary junction	http://purl.obolibrary.org/obo/UBERON_0003988		pheno_slim|human_reference_atlas
UBERON:0001328	biolink:AnatomicalEntity	lobe of prostate	A portion of a prostate that forms a lobe.	BTO:0000548|UMLS:C0227970|EMAPA:35712|FMA:19570|MA:0001738|NCIT:C52726	hp.json	prostate gland lobe|prostatic lobe|lobe of prostate gland	http://purl.obolibrary.org/obo/UBERON_0001328		
HP:0030033	biolink:PhenotypicFeature	Small finger	Significant reduction in both length and girth of the finger compared to the contralateral finger, or alternatively, compared to a typical finger size for an age-matched individual.	UMLS:C0575827|SNOMEDCT_US:299058009	hp.json	Small finger	http://purl.obolibrary.org/obo/HP_0030033		
HP:0032696	biolink:PhenotypicFeature	Focal cognitive seizure with receptive dysphasia/aphasia	A focal cognitive seizure characterized by receptive dysphasia / aphasia as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032696		
HP:0032695	biolink:PhenotypicFeature	obsolete Illusory auras			hp.json		http://purl.obolibrary.org/obo/HP_0032695		
HP:0030034	biolink:PhenotypicFeature	Glomerular basement membrane lamellation	Presence of abnormal additional layers of the basement membrane of the glomerulus.	UMLS:C3278307	hp.json	Lamellation of the glomerular basement membrane|Lamellated/basket-woven thickened glomerular basement membranes	http://purl.obolibrary.org/obo/HP_0030034		
HP:0030035	biolink:PhenotypicFeature	Struvite nephrolithiasis	Presence of struvite (magnesium ammonium phosphate) containing calculi (kidney stones).	UMLS:C4021056	hp.json	Struvite kidney stones	http://purl.obolibrary.org/obo/HP_0030035		
PATO:0001796	biolink:NamedThing	decreased coiling	A coiling which is relatively low.		hp.json	low coiling	http://purl.obolibrary.org/obo/PATO_0001796		cell_quality|value_slim
HP:0032698	biolink:PhenotypicFeature	Focal cognitive seizure with conduction dysphasia/aphasia	A focal cognitive seizure characterized by conduction dysphasia / aphasia as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032698		
HP:0032697	biolink:PhenotypicFeature	obsolete Focal cognitive seizure with deja vu/jamais vu	A focal cognitive seizure characterized by memory phenomena such as feelings of familiarity (deja vu) and unfamiliarity (jamais vu) as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032697		
HP:0030036	biolink:PhenotypicFeature	Isothenuria	Inability of the kidneys to produce either concentrated or dilute urine.	UMLS:C4022665	hp.json		http://purl.obolibrary.org/obo/HP_0030036		
HP:0032692	biolink:PhenotypicFeature	Focal cognitive seizure with forced thinking	A focal cognitive seizure characterized by forced thinking as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032692		
HP:0030030	biolink:PhenotypicFeature	Absent ray	The absence of all phalanges of a digit and the associated metacarpal /metatarsal.	UMLS:C4022668	hp.json		http://purl.obolibrary.org/obo/HP_0030030		
HP:0032691	biolink:PhenotypicFeature	Focal cognitive seizure with dyscalculia/acalculia	A focal cognitive seizure characterized by dyscalculia / acalculia as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032691		
CHEBI:24780	biolink:ChemicalSubstance	imidazoles	A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.		hp.json		http://purl.obolibrary.org/obo/CHEBI_24780		3_STAR
HP:0030031	biolink:PhenotypicFeature	Small toe	Significant reduction in both length and girth of the toe compared to the contralateral toe, or alternatively, compared to a typical toe size for an age-matched individual.	UMLS:C4022667	hp.json	Small toe	http://purl.obolibrary.org/obo/HP_0030031		
HP:0032694	biolink:PhenotypicFeature	Focal cognitive seizure with dyslexia/alexia	A focal cognitive seizure characterized by dyslexia / alexia as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032694		
HP:0030032	biolink:PhenotypicFeature	Partial absence of foot	An incomplete absence of the foot, with no bony elements distal to the tarsals, but with preservation of some or all of the tarsals.	UMLS:C4022666	hp.json	Partial absence of foot	http://purl.obolibrary.org/obo/HP_0030032		
HP:0032693	biolink:PhenotypicFeature	Focal cognitive seizure with neglect	A focal cognitive seizure characterized by neglect as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032693		
PATO:0001790	biolink:NamedThing	decreased mass density	A density which is lower relative to the normal or average.		hp.json	low density	http://purl.obolibrary.org/obo/PATO_0001790		value_slim
PATO:0001794	biolink:NamedThing	coiling	A shape quality inhering in a bearer by virtue of the bearer's being wound in a continuous series of loops.		hp.json		http://purl.obolibrary.org/obo/PATO_0001794		attribute_slim
HP:0030037	biolink:PhenotypicFeature	Bifid ureter	Incomplete duplication of the ureter.	UMLS:C3887498	hp.json		http://purl.obolibrary.org/obo/HP_0030037		
PATO:0001795	biolink:NamedThing	increased coiling	A coiling which is relatively high.		hp.json	high coiling	http://purl.obolibrary.org/obo/PATO_0001795		cell_quality|value_slim
HP:0032699	biolink:PhenotypicFeature	Focal cognitive seizure with dysgraphia/agraphia	A focal cognitive seizure characterized by dysgraphia / agraphia as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032699		
HP:0030038	biolink:PhenotypicFeature	Enchondroma	A solitary, benign, intramedullary cartilage tumor that is often found in the short tubular bones of the hands and feet, distal femur, and proximal humerus.	SNOMEDCT_US:31186001|MSH:D002812|UMLS:C1704356|SNOMEDCT_US:423699002	hp.json		http://purl.obolibrary.org/obo/HP_0030038		
HP:0030039	biolink:PhenotypicFeature	Fused thoracic vertebrae	A congenital anomaly characterized by a joining (fusion) of two or more thoracic vertebral bodies with one another.	UMLS:C4022664	hp.json		http://purl.obolibrary.org/obo/HP_0030039		
PATO:0001793	biolink:NamedThing	right side of	A spatial quality inhering in a bearer by virtue of the bearer's being located on right side of a another entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001793		mpath_slim|relational_slim|value_slim
UBERON:0001334	biolink:AnatomicalEntity	female urethra	A urethra that is part of a female reproductive system.	UMLS:C0458485|NCIT:C32591|EMAPA:28747|MA:0002637|FMA:19669|BTO:0004088	hp.json	urethra feminina|urethra muliebris	http://purl.obolibrary.org/obo/UBERON_0001334		pheno_slim|uberon_slim
UBERON:0001333	biolink:AnatomicalEntity	male urethra	A urethra that is part of a male reproductive system.	MA:0002640|EMAPA:18692|UMLS:C0458452|NCIT:C33050|FMA:19668|BTO:0004089	hp.json		http://purl.obolibrary.org/obo/UBERON_0001333		pheno_slim|uberon_slim
UBERON:0001330	biolink:AnatomicalEntity	pampiniform plexus	The pampiniform plexus is a network of many small veins found in the male spermatic cord. It is formed by the union of multiple spermatic veins from the back of the testis and tributaries from the epididymis. The veins of the plexus ascend along the cord in front of the ductus deferens. Below the subcutaneous inguinal ring they unite to form three or four veins, which pass along the inguinal canal, and, entering the abdomen through the abdominal inguinal ring, coalesce to form two veins. These again unite to form a single vein, the testicular vein, which opens on the right side into the inferior vena cava, at an acute angle, and on the left side into the left renal vein, at a right angle. The pampinoform plexus forms the chief mass of the cord. In addition to its function in venous return from the testes, the pampiniform plexus also plays a role in the temperature regulation of the testes. It acts as a heat exchanger, cooling blood in adjacent arteries. An abnormal enlargement of the pampiniform plexus is a medical condition called varicocele. [WP,unvetted].	FMA:19607|EMAPA:37385|MA:0001866	hp.json	venous plexus of fascia of prostate gland|venous plexus of fascia of prostate|pampiniform venous plexus|plexus of veins of fascia of prostate|plexus venosus pampiniformis	http://purl.obolibrary.org/obo/UBERON_0001330		human_reference_atlas|uberon_slim
UBERON:0001332	biolink:AnatomicalEntity	prepuce of penis	A retractable double-layered fold of skin and mucous membrane that covers the glans penis and protects the urinary meatus when the penis is not erect.	OpenCyc:Mx4rvVjlTZwpEbGdrcN5Y29ycA|EFO:0001664|BTO:0001113|MA:0000407|FMA:19639|EMAPA:18989|EV:0100109|UMLS:C0227952|NCIT:C33049|CALOHA:TS-0383	hp.json	preputium penis|praeputium|preputium|prepucium|foreskin|penile prepuce|prepuce|prepuce of male	http://purl.obolibrary.org/obo/UBERON_0001332		pheno_slim|efo_slim|uberon_slim
UBERON:0001331	biolink:AnatomicalEntity	skin of penis	A zone of skin that is part of a penis [Automatically generated definition].	MA:0002727|FMA:19638|EMAPA:35675	hp.json	penis skin|zone of skin of penis|penile skin|penis zone of skin	http://purl.obolibrary.org/obo/UBERON_0001331		
UBERON:0001319	biolink:AnatomicalEntity	vaginal vein	One the veins that drains the vaginal venous plexus, into the hypogastric veins. [WP,modified].	FMA:18899|EMAPA:37796|MA:0002251	hp.json	vein of vagina|vagina vein	http://purl.obolibrary.org/obo/UBERON_0001319		uberon_slim|human_reference_atlas
UBERON:0001316	biolink:AnatomicalEntity	external iliac vein	A large vein that connects the femoral vein to the common iliac vein. Their origin is at the inferior margin of the inguinal ligaments and they terminate when they join the internal iliac veins (to form the common iliac veins). Both external iliac veins are accompanied along their course by external iliac arteries. [WP,modified].	FMA:18883|UMLS:C0226761|MA:0002144|EHDAA2:0000464|NCIT:C32560|OpenCyc:Mx4rwQUYtZwpEbGdrcN5Y29ycA|EMAPA:37144|galen:ExternalIliacVein	hp.json	vena iliaca externa	http://purl.obolibrary.org/obo/UBERON_0001316		uberon_slim|human_reference_atlas
UBERON:0001317	biolink:AnatomicalEntity	internal iliac vein	A vein that begins near the upper part of the greater sciatic foramen, passes upward behind and slightly medial to the hypogastric artery and, at the brim of the pelvis, joins with the external iliac to form the common iliac vein. [WP,unvetted].	galen:InternalIliacVein|MA:0002139|UMLS:C0226764|FMA:18884|EHDAA2:0000874|VHOG:0000749|MA:0002145|EMAPA:37148|NCIT:C32847	hp.json	hypogastric vein|v. iliaca interna|v. hypogastrica	http://purl.obolibrary.org/obo/UBERON_0001317		uberon_slim|human_reference_atlas
UBERON:0003978	biolink:AnatomicalEntity	valve		EHDAA:4406|OpenCyc:Mx4rvqiwE5wpEbGdrcN5Y29ycA|EHDAA:1892|EHDAA2:0004046|FMA:67611|galen:Valve	hp.json	anatomical valve	http://purl.obolibrary.org/obo/UBERON_0003978		grouping_class
HP:0030044	biolink:PhenotypicFeature	Flexion contracture of digit	A bent (flexed) finger or toe joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints.	UMLS:C1839864	hp.json		http://purl.obolibrary.org/obo/HP_0030044		
HP:0030045	biolink:PhenotypicFeature	Serpentine fibula	Elongated curved (S-shaped) fibulae.	UMLS:C3805325	hp.json	S-shaped calf bone	http://purl.obolibrary.org/obo/HP_0030045		
HP:0030046	biolink:PhenotypicFeature	Hypoglycosylation of alpha-dystroglycan	A reduction in the degree of glycosylation of alpha-dystroglycan in muscle tissue.	UMLS:C4015098	hp.json		http://purl.obolibrary.org/obo/HP_0030046		
HP:0030047	biolink:PhenotypicFeature	Abnormal lateral ventricle morphology	A morphological anomaly of the lateral ventricle.	UMLS:C4022662	hp.json	Abnormality of lateral ventricle	http://purl.obolibrary.org/obo/HP_0030047		
HP:0030040	biolink:PhenotypicFeature	Fused lumbar vertebrae	A congenital anomaly characterized by a joining (fusion) of two or more lumbar vertebral bodies with one another.	UMLS:C4022663	hp.json		http://purl.obolibrary.org/obo/HP_0030040		
HP:0030041	biolink:PhenotypicFeature	Schmorl's node	A Schmorl's node is the herniation of nucleus pulposus through the cartilaginous and bony end plate into the body of the adjacent vertebra.	SNOMEDCT_US:45181002|UMLS:C0410632	hp.json	Schmorl's nodes	http://purl.obolibrary.org/obo/HP_0030041		
HP:0030042	biolink:PhenotypicFeature	Incomplete ossification of pubis	Failure to complete ossification (maturation and calcification) of the pubic bone.	SNOMEDCT_US:373940002|UMLS:C0685678	hp.json	Incomplete maturation of the pubic bone	http://purl.obolibrary.org/obo/HP_0030042		
HP:0030043	biolink:PhenotypicFeature	Hip subluxation	A partial dislocation of the hip joint, whereby the head of the femur is partially displaced from the socket.	SNOMEDCT_US:263057000|UMLS:C0434785	hp.json	Partial hip dislocation|Subluxation involving the hip joint	http://purl.obolibrary.org/obo/HP_0030043		
HP:0030048	biolink:PhenotypicFeature	Colpocephaly	Colpocephaly is an anatomic finding in the brain manifested by occipital horns that are disproportionately enlarged in comparison with other parts of the lateral ventricles.	SNOMEDCT_US:253160006|UMLS:C0431384|MSH:C535973	hp.json		http://purl.obolibrary.org/obo/HP_0030048		
HP:0030049	biolink:PhenotypicFeature	Brain abscess	A collection of pus, immune cells, and other material in the brain.	UMLS:C0006105|MSH:D001922|SNOMEDCT_US:441806004	hp.json	Brain abscess	http://purl.obolibrary.org/obo/HP_0030049		
UBERON:0001323	biolink:AnatomicalEntity	tibial nerve	The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus. In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a cutaneous branch that will become the sural nerve. The sural nerve is joined by fibres from the common peroneal nerve and runs down the calf to supply the lateral side of the foot. Below the soleus muscle the nerve lies close to the tibia and supplies the tibialis posterior, the flexor digitorum longus and the flexor hallucis longus. The nerve passes into the foot running posterior to the medial malleolus. Here it is bound down by the flexor retinaculum in company with the posterior tibial artery. [WP,unvetted].	NCIT:C52809|FMA:19035|MA:0001173|UMLS:C0040186|EMAPA:36512|OpenCyc:Mx4rwNya8JwpEbGdrcN5Y29ycA|GAID:854|MESH:D013979	hp.json	medial popliteal nerve|n. tibialis	http://purl.obolibrary.org/obo/UBERON_0001323		uberon_slim
UBERON:0001322	biolink:AnatomicalEntity	sciatic nerve	A large nerve that supplies nearly the whole of the skin of the leg, the muscles of the back of the thigh, and those of the leg and foot. It begins in the lower back and runs through the buttock and down the lower limb.	EFO:0001417|FMA:19034|OpenCyc:Mx4rv7MlDJwpEbGdrcN5Y29ycA|UMLS:C0036394|MESH:D012584|CALOHA:TS-0899|UMLS:C0036394|MA:0001172|VHOG:0000894|BTO:0001221|NCIT:C52810|GAID:852|EHDAA2:0001779|EHDAA:5659|EMAPA:18577|BIRNLEX:1133	hp.json	nervus ischiadicus|nervus sciaticus|ischiadic nerve|ischiatic nerve|nervus ischiadicus	http://purl.obolibrary.org/obo/UBERON_0001322		pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0003984	biolink:AnatomicalEntity	uterine tube infundibulum	The funnel-like expansion of the abdominal extremity of the uterine tube[MP].	SCTID:362262001|FMA:18307|EMAPA:29897|Wikipedia:Infundibulum_of_uterine_tube	hp.json	infundibulum of uterine tube|infundibulum of fallopian tube|infundibulum of oviduct|infundibulum tubae uterinae|infundibulum tubae uterinae|infundibulum	http://purl.obolibrary.org/obo/UBERON_0003984		pheno_slim|human_reference_atlas
UBERON:0001325	biolink:AnatomicalEntity	muscle of pelvis	Muscle (organ) which is a part of the pelvis. Examples: levator ani,.	FMA:19086|EMAPA:18184|MA:0000534|EMAPA:37481	hp.json	pelvis muscle organ|pelvis muscle|muscle organ of pelvis|pelvic muscle	http://purl.obolibrary.org/obo/UBERON_0001325		pheno_slim|uberon_slim
UBERON:0003983	biolink:AnatomicalEntity	conus arteriosus	A conical pouch formed from the upper and left angle of the right ventricle in the chordate heart, from which the pulmonary artery arises[WP]. the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminates in the pulmonary trunk[MP].	AAO:0010250|Wikipedia:Conus_arteriosus	hp.json		http://purl.obolibrary.org/obo/UBERON_0003983		
UBERON:0003980	biolink:AnatomicalEntity	cerebellum fissure	One of a set of deep furrows which divide the lobules of the cerebellum. Examples: postcentral, primary and secondary furrows.	DHBA:12828|FMA:321547|HBA:9406|BAMS:CBf|EMAPA:37818	hp.json	sulcus of cerebellum|cerebellar fissures set|cerebellar sulcus|cerebellar sulci|fissurae cerebelli|cerebellar fissures|cerebellar fissure|set of cerebellar fissures	http://purl.obolibrary.org/obo/UBERON_0003980		pheno_slim
PATO:0001739	biolink:NamedThing	radiation quality			hp.json		http://purl.obolibrary.org/obo/PATO_0001739		
HP:0032630	biolink:PhenotypicFeature	Intratubular light-chain casts	The presence of casts containing immunoglobulin light chains within the lumina of the renal tubules.		hp.json		http://purl.obolibrary.org/obo/HP_0032630		
HP:0032632	biolink:PhenotypicFeature	Renal papillary necrosis	Premature death of cells in the renal papilla (the apex of a renal pyramid which projects into the cavity of a calyx of the kidney and through which collecting ducts discharge urine). Histologically, one observes pale tissue with typical appearance of coagulative necrosis, affecting the renal papillae. Necrosis can be identified by pyknotic nuclei and simplified, flattened epithelium of proximal tubules. The tubular and glomerular basement membranes are still visible without viable nuclei.		hp.json		http://purl.obolibrary.org/obo/HP_0032632		
HP:0032631	biolink:PhenotypicFeature	Intratubular hemoglobin casts	A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented. On H&E (red granular), PAS (purple), trichrome (red granular), Hall (yellow brown). Stain positively for Hemoglobin A.		hp.json	Intratubular haemoglobin casts	http://purl.obolibrary.org/obo/HP_0032631		
PATO:0001736	biolink:NamedThing	solid configuration	A physical quality inhering in a bearer by virtue of the bearer's parts having the arrangement which exhibits characteristics of solids.		hp.json	solid	http://purl.obolibrary.org/obo/PATO_0001736		value_slim
PATO:0001735	biolink:NamedThing	liquid configuration			hp.json		http://purl.obolibrary.org/obo/PATO_0001735		
HP:0032638	biolink:PhenotypicFeature	Elevated urine mevalonic acid	An abnormally increased amount of mevanolate in the urine. Mevanolate is that hydroxy monocarboxylic acid anion that is the conjugate base of mevalonic acid.		hp.json	Elevated urine mevalonate levels|Elevated urine mevalonate|Mevalonate aciduria	http://purl.obolibrary.org/obo/HP_0032638		
HP:0005008	biolink:PhenotypicFeature	Large joint dislocations		UMLS:C4025260	hp.json	Large joint dislocations	http://purl.obolibrary.org/obo/HP_0005008		
HP:0005009	biolink:PhenotypicFeature	Dumbbell-shaped humerus	The humerus is shortened and displays flaring (widening) of the metaphyses.	UMLS:C4025259	hp.json	Dumbbell-shaped long bone in upper arm	http://purl.obolibrary.org/obo/HP_0005009		
HP:0032637	biolink:PhenotypicFeature	Renal interstitial edema	Edema is characterized but the acute swelling of the stroma, with expansion of the interstitial space without the a concurrent increase in interstitial cells or extracellular matrix. Histologically this change is appreciated as interstitial areas of lower optical density.		hp.json	Renal interstitial oedema	http://purl.obolibrary.org/obo/HP_0032637		
HP:0032639	biolink:PhenotypicFeature	Elevated leukocyte cystine	An increased concentration of cystine within white blood cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032639		
HP:0032634	biolink:PhenotypicFeature	Intratubular myoglobin cast	Casts located within the tubuli of the kidney and that contain myoglobin. Myoglobin casts are composed of round granules that may line up in chains or aggregate in clusters. Their color ranges from pink to red-brown with hematoxylin and eosin stain, light brown to black with Jones methenamine silver stain, pink to bright magenta with periodic acid-Schiff stain, and bright red with trichrome stain. Immunoperoxidase staining with antibody to myoglobin is stronglypositive in the casts.Electron microscopy shows globular casts with an electron-dense core and a somewhat less-intense periphery. Substructure is absent. This feature may be accompanied by acute tubular injury with variable flattening of tubular epithelial cells, loss of brush borders, and intratubular sloughed epithelial cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032634		
HP:0007667	biolink:PhenotypicFeature	Peripheral cystoid retinal degeneration	Degenerative changes of the peripheral retina consisting of close-packed tiny cystic spaces at the outer plexiform/inner nuclear retinal level. The degeneration is very common in adult eyes and starts adjacent to the ora serrata and extends circumferentially and posteriorly.	UMLS:C1839362	hp.json	Peripheral cystoid degeneration|Cystic retinal degeneration	http://purl.obolibrary.org/obo/HP_0007667		
HP:0005004	biolink:PhenotypicFeature	Flattened proximal radial epiphyses	An abnormally flat form of the proximal epiphysis of the radius.	UMLS:C1849065	hp.json		http://purl.obolibrary.org/obo/HP_0005004		
HP:0005005	biolink:PhenotypicFeature	Femoral bowing present at birth, straightening with time	Congenital onset bending or abnormal curvature of the femur that normalizes with age.	UMLS:C1833754	hp.json	Bowing of thighbone at birth, straightening with time	http://purl.obolibrary.org/obo/HP_0005005		
HP:0032633	biolink:PhenotypicFeature	Intratubular hyaline casts	A type of acellular urinary cast located within the distal tubules of the kidney and that is composed only of Tamm-Horsfall glycoprotein. Correspondingly, these casts have a low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends.		hp.json	Intratubular Tamm-Horsfall (uromodulin) casts	http://purl.obolibrary.org/obo/HP_0032633		
HP:0032636	biolink:PhenotypicFeature	Tubulointerstitial viral infiltration	Infiltration of viruses into renal tubulointerstitial tissues as demonstrated on renal biopsy by viral inclusions which can be seen on routine stains or with immunohistochemistry.		hp.json	Renal tubulointerstitial viral inclusions	http://purl.obolibrary.org/obo/HP_0032636		
HP:0032635	biolink:PhenotypicFeature	Tubulointerstitial microganismal infiltration	Infiltration of microorganisms into renal tubulointerstitial tissues as observed by appropriate staining procedures, e.g., bacteria on a bacterial stain (Brown and Hopps) or fungi on PAS or silver stain.		hp.json		http://purl.obolibrary.org/obo/HP_0032635		
HP:0007668	biolink:PhenotypicFeature	Impaired pursuit initiation and maintenance		UMLS:C1969722	hp.json		http://purl.obolibrary.org/obo/HP_0007668		
HP:0007663	biolink:PhenotypicFeature	Reduced visual acuity		UMLS:C0234632|SNOMEDCT_US:13164000	hp.json	Decreased clarity of vision|Decreased visual acuity|Decreased central vision|Poor visual acuity	http://purl.obolibrary.org/obo/HP_0007663		
HP:0005001	biolink:PhenotypicFeature	Recurrent patellar dislocation	Patellar dislocation occurring repeated times.	UMLS:C0409412|SNOMEDCT_US:202246002	hp.json	Recurrent dislocation of patellas	http://purl.obolibrary.org/obo/HP_0005001		
HP:0007665	biolink:PhenotypicFeature	Curly eyelashes	Abnormally curly or curved eyelashes.	UMLS:C2673670	hp.json	Curly eyelashes	http://purl.obolibrary.org/obo/HP_0007665		hposlim_core
HP:0005003	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the capital femoral epiphysis	Absence or underdevelopment of the proximal epiphysis of the femur.	UMLS:C4025261	hp.json	Absent/underdeveloped end part of innermost thighbone|Absent/small end part of innermost thighbone	http://purl.obolibrary.org/obo/HP_0005003		
HP:0007661	biolink:PhenotypicFeature	Abnormality of chorioretinal pigmentation		UMLS:C4024819	hp.json		http://purl.obolibrary.org/obo/HP_0007661		
HP:0032641	biolink:PhenotypicFeature	Renal interstitial granulomas	Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present.		hp.json	Renal interstitial granulomata	http://purl.obolibrary.org/obo/HP_0032641		
HP:0032640	biolink:PhenotypicFeature	Elevated circulating CCL18 level	An increased concentration of C-C motif chemokine ligand 18 in the blood circulation.		hp.json	Increased C-C motif chemokine ligand 18 concentration	http://purl.obolibrary.org/obo/HP_0032640		
HP:0032643	biolink:PhenotypicFeature	Renal interstitial non-necrotizing granulomas	Interstital aggregates of histiciocytes, occasionally multinucleated with associated lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined and multinucleated giant cells may be present with no necrosis.		hp.json	Renal interstitial non-necrotizing granulomata	http://purl.obolibrary.org/obo/HP_0032643		
HP:0032642	biolink:PhenotypicFeature	Renal interstitial necrotizing granulomas	An organized collection of histiocytes (specifically macrophages) localized in the interstitial tissue of the kidney. Through light microscopy, the activated histiocytes appear as epithelioid cells with round to oval nuclei, often with irregular contours and abundant granular eosinophilic cytoplasm with indistinct cell borders. They may also coalesce to form multinucleated giant cells. Granulomas may be associated with a peripheral cuff of lymphoplasmacytic and occcasionally eosinophilic inflammation. Organization can range from poorly-to-well defined. Granulomas can present as necrotizing or non-necrotizing. Microscopically, necrotizing granulomas distinctly have central necrosis with a palisaded lymphohistiocytic reaction and a cuff of chronic inflammation.		hp.json	Renal interstitial necrotizing granulomata	http://purl.obolibrary.org/obo/HP_0032642		
PATO:0001748	biolink:NamedThing	invaginated	A shape quality in which a portion of the outermost boundary of an entity folds in space such that a portion that was originally convex is now concave.		hp.json		http://purl.obolibrary.org/obo/PATO_0001748		value_slim|mpath_slim|cell_quality
HP:0032649	biolink:PhenotypicFeature	Skewfoot	A type of flat-foot characterized by hindfoot abductovalgus, metatarsus adductus, and Achilles tendon shortening. The predominant radiographic findings include forefoot adduction with lateral subluxation of the navicular on the talus and heel valgus. Very abnormal shoe wear is noted on the medial side. Calluses occurunder the metatarsal heads and thehead of the plantar-flexed talus.		hp.json	Skew foot|Skew-foot	http://purl.obolibrary.org/obo/HP_0032649		
HP:0005019	biolink:PhenotypicFeature	Diaphyseal thickening		UMLS:C1835473	hp.json	Thickening of shaft or central part of long bones	http://purl.obolibrary.org/obo/HP_0005019		
HP:0032648	biolink:PhenotypicFeature	Tubularization of Bowman capsule	The presence of cuboidal to columnar epithelium (height greater than width) lining the Bowman capsule, in an absence of adjacent segmental sclerosis, crescents, or collapsing variant of focal segmental glomerulosclerosis; scored as present or absent in at least one glomerulus.		hp.json		http://purl.obolibrary.org/obo/HP_0032648		
HP:0007678	biolink:PhenotypicFeature	Lacrimal duct stenosis	Narrowing of a tear duct (lacrimal duct).	UMLS:C0238300|SNOMEDCT_US:231841004	hp.json	Nasolacrimal duct stenosis|Narrowing of the tear duct	http://purl.obolibrary.org/obo/HP_0007678		
HP:0032645	biolink:PhenotypicFeature	Renal interstitial mononuclear cell infiltration	Presence of interstitial mononuclear leukocytes, i.e., white blood ceclls with a single round nucleus, including lymphocytes and monocytes but not including granulocytes (which have multilobed nuclei).		hp.json		http://purl.obolibrary.org/obo/HP_0032645		
HP:0007677	biolink:PhenotypicFeature	Vitelliform-like macular lesions	Vitelliform maculopathy is a sharply demarcated lesion caused by the accumulation of material, often lipofuscin in the subretinal space underlying the macula.	MSH:D057826|UMLS:C0339510|SNOMEDCT_US:90036004|UMLS:C4024817	hp.json	Vitelliform macular dystrophy|Vitelliform macular lesions	http://purl.obolibrary.org/obo/HP_0007677		
HP:0032644	biolink:PhenotypicFeature	Renal interstitial deposits	Abnormal accumulation of a metabolite, protein, or protein-derived substance in the interstitial region of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032644		
HP:0032647	biolink:PhenotypicFeature	Renal tubular epithelial cell apoptosis	Increased apoptosis (programmed cell death) of tubular epithelial cells. The cells arre rounded with increased eosinophilia and contain fragmented, densely basophilic nuclear debris.		hp.json		http://purl.obolibrary.org/obo/HP_0032647		
HP:0005017	biolink:PhenotypicFeature	Polyarticular chondrocalcinosis		UMLS:C4025258	hp.json		http://purl.obolibrary.org/obo/HP_0005017		
HP:0032646	biolink:PhenotypicFeature	Renal interstitial xanthogranulomatous inflammation	Inflammation of interstitial tissues of the kidney consisting of foamy macrophages admixed with plasma cells, lymphocytes and neutrophils and occasional giant cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032646		
HP:0005011	biolink:PhenotypicFeature	Mesomelic arm shortening	Shortening of the middle parts of the arm in relation to the upper and terminal segments.	UMLS:C1862087	hp.json	Upper limb brachymesomelia|Mesomelia of the upper limbs	http://purl.obolibrary.org/obo/HP_0005011		
HP:0007676	biolink:PhenotypicFeature	Hypoplasia of the iris	Congenital underdevelopment of the iris.	UMLS:C0344539|SNOMEDCT_US:95714006	hp.json	Underdeveloped iris|Hypoplastic iris|Iris hypoplasia	http://purl.obolibrary.org/obo/HP_0007676		hposlim_core
HP:0005013	biolink:PhenotypicFeature	Dysplastic distal radial epiphyses	Abnormally developed (dysplastic) distal epiphysis of the radius.	UMLS:C1862131	hp.json		http://purl.obolibrary.org/obo/HP_0005013		
HP:0007675	biolink:PhenotypicFeature	Progressive night blindness		UMLS:C4024818	hp.json	Progressive night blindness	http://purl.obolibrary.org/obo/HP_0007675		
HP:0007670	biolink:PhenotypicFeature	Abnormal vestibulo-ocular reflex	An abnormality of the vestibulo-ocular reflex (VOR). The VOR attempts to keep the image stable on the retina. Ideally passive or active head movements in one direction are compensated for by eye movements of equal magnitude.	UMLS:C4021571	hp.json	Abnormal vestibuloocular reflex	http://purl.obolibrary.org/obo/HP_0007670		
HP:0005010	biolink:PhenotypicFeature	Osteomyelitis leading to amputation due to slow healing fractures		UMLS:C1864975	hp.json		http://purl.obolibrary.org/obo/HP_0005010		
HP:0032652	biolink:PhenotypicFeature	Elevated CSF chitotriosidase 1 level	Increased concentration of chitotriosidase 1 in cerebrospinal fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0032652		
HP:0032651	biolink:PhenotypicFeature	Elevated CSF chitinase-3-like protein 1 level	Increased concentration of chitinase-3-like protein 1 in cerebrospinal fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0032651		
HP:0032654	biolink:PhenotypicFeature	Impaired flow-mediated arterial dilatation	Flow-mediated dilatation is a noninvasive tests of endothelial function that leverages ultrasound to measure arterial diameter and its response to an increase in shear stress, which normally causes endothelium-dependent dilatation. This term pertains to an abnormal reduction in the magnitude of dilatation. Flow-mediated dilatation is usually measured at the brachial artery.		hp.json	Endothelial dysfunction	http://purl.obolibrary.org/obo/HP_0032654		
HP:0032653	biolink:PhenotypicFeature	Elevated lactate:pyruvate ratio	An abnormal increase in the molar ratio of lactate to pyruvate in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032653		
HP:0032650	biolink:PhenotypicFeature	Elevated CSF glial fibrillary acidic protein level	Increased concentration of glial fibrillary acidic protein in cerebrospinal fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0032650		
HP:0007649	biolink:PhenotypicFeature	Congenital hypertrophy of retinal pigment epithelium	Sharply demarcated, congenital hyperpigmentation of the retinal pigment epithelium.	UMLS:C0339555|SNOMEDCT_US:232074003	hp.json		http://purl.obolibrary.org/obo/HP_0007649		
HP:0007648	biolink:PhenotypicFeature	Punctate cataract	A type of cataract with punctate opacities of the lens.	UMLS:C0271165|UMLS:C1969675|SNOMEDCT_US:40714009	hp.json	Punctate lenticular opacities	http://purl.obolibrary.org/obo/HP_0007648		
HP:0032659	biolink:PhenotypicFeature	Non-convulsive status epilepticus with coma	A type of status epilepticus without prominent motor symptoms and in the presence of coma.		hp.json	Subtle status epilepticus	http://purl.obolibrary.org/obo/HP_0032659		
HP:0032656	biolink:PhenotypicFeature	Febrile status epilepticus	A seizure lasting 30 minutes without fully regaining consciousness, provoked by fever (temperature greater than 38.0 degrees Celcius) at the time of seizure-onset, without a prior history of afebrile seizure and with no evidence of an acute central nervous system infection or insult.		hp.json	Fever-induced status epilepticus	http://purl.obolibrary.org/obo/HP_0032656		
HP:0032655	biolink:PhenotypicFeature	Decreased adipose tissue tocopherol level	A reduced concentration of tocopherol in fat tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0032655		
HP:0032658	biolink:PhenotypicFeature	Status epilepticus with prominent motor symptoms	Status epilepticus with prominent motor signs during the prolonged seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032658		
HP:0007647	biolink:PhenotypicFeature	Congenital extraocular muscle anomaly	Congenital abnormality of the extraocular muscles.	UMLS:C4024823	hp.json		http://purl.obolibrary.org/obo/HP_0007647		
HP:0007646	biolink:PhenotypicFeature	Absent lower eyelashes	Lack of eyelashes on the lower lid.	UMLS:C4024824	hp.json	Atrichia of lower eyelashes|Aplasia of lower eyelashes|Agenesis of lower eyelashes|Absent lower eyelashes|Failure of development of lower eyelashes	http://purl.obolibrary.org/obo/HP_0007646		
HP:0032657	biolink:PhenotypicFeature	Elevated circulating lyso-globotriaosylsphingosine concentration	An abnormal increase in the level of globotriaosylsphingosine (Lyso-Gb3) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032657		
HP:0007641	biolink:PhenotypicFeature	Dyschromatopsia	A form of colorblindness in which only two of the three fundamental colors can be distinguished due to a lack of one of the retinal cone pigments.	UMLS:C0858618	hp.json	Color blindness|Colour blindness	http://purl.obolibrary.org/obo/HP_0007641		
HP:0007643	biolink:PhenotypicFeature	Peripheral tractional retinal detachment	Tractional retinal detachment at the periphery of the retina.	UMLS:C4024825	hp.json	Peripheral traction retinal detachment|Tractional retinal detachment at the periphery of the retina	http://purl.obolibrary.org/obo/HP_0007643		
HP:0007642	biolink:PhenotypicFeature	Congenital stationary night blindness	A nonprogressive (i.e., stationary) form of difficulties with night blindness with congenital onset.	SNOMEDCT_US:232061009|MSH:C537743|UMLS:C3551052|UMLS:C0339535|MSH:C536122|UMLS:C1306122|SNOMEDCT_US:193687000|UMLS:C4048798	hp.json	Congenital night blindness|Night blindness, stationary|Static congenital hemeralopia|Night blindness, congenital|Night blindness since birth|Night blindness, congenital stationary|Night blindness, congenital stationary, complete	http://purl.obolibrary.org/obo/HP_0007642		
HP:0032663	biolink:PhenotypicFeature	Focal motor status epilepticus	Status epilepticus with focal motor signs originating within networks limited to one hemisphere. Involves musculature in any form. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement.		hp.json		http://purl.obolibrary.org/obo/HP_0032663		
HP:0030000	biolink:PhenotypicFeature	EMG: repetitive nerve stimulation abnormality	Abnormality observed upon electromyography when nerve studied is electrically stimulated six to ten times at 2 or 3 Hertz.	UMLS:C4022681	hp.json		http://purl.obolibrary.org/obo/HP_0030000		
HP:0032662	biolink:PhenotypicFeature	Focal-onset seizure evolving into bilateral convulsive status epilepticus	A type of bilateral convulsive seizure of focal onset (which could be with awareness or impaired awareness, either motor or non- motor) that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus.		hp.json	Focal-onset seizure evolving into generalised convulsive status epilepticus|Secondarily generalized tonic-clonic status epilepticus|Secondarily generalised convulsive status epilepticus|Focal onset seizure evolving into bilateral convulsive status epilepticus|Partial-onset seizure evolving into convulsive status epilepticus|Secondarily generalised tonic-clonic status epilepticus|Partial onset seizure evolving into convulsive status epilepticus|Focal-onset seizure evolving into generalized convulsive status epilepticus|Secondarily generalized convulsive status epilepticus	http://purl.obolibrary.org/obo/HP_0032662		
HP:0030001	biolink:PhenotypicFeature	Lagopthalmos	A condition in which the eyelids do not close to cover the eye completely.	UMLS:C4022680	hp.json	Eyelids stay open|Inability to close the eyelids	http://purl.obolibrary.org/obo/HP_0030001		
CHEBI:58190	biolink:ChemicalSubstance	O-phosphonatoethanaminium(1-)	An organophosphate oxoanion that is the conjugate base of O-phosphoethanolamine arising from deprotonation of the phosphate OH groups and protonation of the amino group; major species at pH 7.3.		hp.json	phosphoethanolamine|2-azaniumylethyl phosphate|O-phosphonatoethanaminium|2-ammonioethyl phosphate	http://purl.obolibrary.org/obo/CHEBI_58190		3_STAR
HP:0032665	biolink:PhenotypicFeature	Repeated focal motor seizures	A type of focal motor status epilepticus characterized by repeated motor, typically clonic events repeatedly affecting the same segments of the body with spread of clonic movements through contiguous body parts unilaterally, and repeating over a sufficiently prolonged period to reach a diagnosis of status epilepticus.		hp.json	Jacksonian status epilepticus	http://purl.obolibrary.org/obo/HP_0032665		
HP:0030002	biolink:PhenotypicFeature	Nocturnal lagophthalmos	The inability to close the eyelids during sleep.	SNOMEDCT_US:417740005|UMLS:C1563118	hp.json	Inability to close the eyelids at night|Eyelids stay open at night	http://purl.obolibrary.org/obo/HP_0030002		
HP:0032664	biolink:PhenotypicFeature	Adversive status epilepticus	A type of focal motor status epilepticus characterized by continuous neck or body rotation and conjugate gaze deviation in a direction contralateral to the responsible epileptic focus. This includes some forms of tonic status epilepticus.		hp.json		http://purl.obolibrary.org/obo/HP_0032664		
HP:0030003	biolink:PhenotypicFeature	Paralytic lagophthalmos	A type of lagophthalmos that occurs in association with facial nerve palsy.	UMLS:C0155197|SNOMEDCT_US:59890007	hp.json		http://purl.obolibrary.org/obo/HP_0030003		
HP:0032661	biolink:PhenotypicFeature	Generalized convulsive status epilepticus	A type of bilateral convulsive seizure of generalized onset that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus.		hp.json	Generalised convulsive status epilepticus	http://purl.obolibrary.org/obo/HP_0032661		
HP:0032660	biolink:PhenotypicFeature	Convulsive status epilepticus	A type of status epilepticus characterized by a prolonged bilateral tonic-clonic seizure, or repeated bilateral tonic-clonic seizures without recovery between. comment:  source:  seeAlso: Tonic-clonic status epilepticus		hp.json	Tonic-clonic status epilepticus	http://purl.obolibrary.org/obo/HP_0032660		
HP:0030008	biolink:PhenotypicFeature	Cervical agenesis	Congenital absence of the cervix.	UMLS:C0266404|SNOMEDCT_US:37687000	hp.json	Cervical aplasia|Absent cervix|Aplasia of the cervix	http://purl.obolibrary.org/obo/HP_0030008		
HP:0030009	biolink:PhenotypicFeature	Cervical insufficiency	A cervix that shows a painless dilation and shortening during the second trimester of pregnancy with resultant recurrent pregnancy loss or delivery is considered incompetent	MSH:D002581|SNOMEDCT_US:17382005|UMLS:C0007871	hp.json	Incompetent cervix	http://purl.obolibrary.org/obo/HP_0030009		
HP:0007659	biolink:PhenotypicFeature	obsolete Decreased retinal pigmentation with dispersion			hp.json		http://purl.obolibrary.org/obo/HP_0007659		
HP:0030004	biolink:PhenotypicFeature	Cicatricial lagophthalmos	A type of lagophthalmos that occurs following trauma or surgery.	UMLS:C0155199|SNOMEDCT_US:9042000	hp.json	Eyelids stay open due to scarring|Inability to close the eyelids due to scarring	http://purl.obolibrary.org/obo/HP_0030004		
HP:0032667	biolink:PhenotypicFeature	Myoclonic status epilepticus	A type of motor status epilepticus with repeating bilateral sudden brief (less than 100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography.		hp.json		http://purl.obolibrary.org/obo/HP_0032667		
HP:0007656	biolink:PhenotypicFeature	Lacrimal gland aplasia	A congenital defect of development characterized by absence of the lacrimal gland.	UMLS:C4024822	hp.json	Absent tear gland	http://purl.obolibrary.org/obo/HP_0007656		
HP:0030005	biolink:PhenotypicFeature	Capillary leak	An acute phenomenon characterized by hypotension and anasarca due to the loss of plasma volume into peripheral tissues, with evidence of decreased plasma volume (hemoconcentration) and protein loss from the intravascular space (hypoalbuminemia) during acute episodes.	UMLS:C1382398|MSH:D019559|SNOMEDCT_US:87730004|UMLS:C0343084|SNOMEDCT_US:1608005	hp.json	Systemic capillary leak syndrome|Increased capillary permeability	http://purl.obolibrary.org/obo/HP_0030005		
HP:0007655	biolink:PhenotypicFeature	Eversion of lateral third of lower eyelids		UMLS:C1835801	hp.json		http://purl.obolibrary.org/obo/HP_0007655		
HP:0032666	biolink:PhenotypicFeature	Hyperkinetic status epilepticus	Status epilepticus characterized by continuous hyperkinetic proximal limb or axial muscles producing irregular sequential ballistic movements such as pedaling pelvic thrusting, thrashing, or rocking movements.		hp.json		http://purl.obolibrary.org/obo/HP_0032666		
HP:0032669	biolink:PhenotypicFeature	Myoclonic status epilepticus with coma	A type of myoclonic status epilepticus in the presence of coma.		hp.json		http://purl.obolibrary.org/obo/HP_0032669		
HP:0030006	biolink:PhenotypicFeature	Single fiber EMG abnormality	Abnormality in single fiber EMG recording, a technique that allows identification of action potentials (APs) from individual muscle fibers.	UMLS:C4022679	hp.json	Single fibre EMG abnormality	http://purl.obolibrary.org/obo/HP_0030006		
HP:0007658	biolink:PhenotypicFeature	Large hyperpigmented retinal spots		UMLS:C4024820	hp.json		http://purl.obolibrary.org/obo/HP_0007658		
HP:0030007	biolink:PhenotypicFeature	EMG: positive sharp waves	These are spontaneous firing action potentials stimulated by needle movement of an injured muscle fiber. There is propagation to, but not past, the needle tip. This inhibits the display of the negative deflection of the waveform.	SNOMEDCT_US:251527008|UMLS:C0429349	hp.json		http://purl.obolibrary.org/obo/HP_0030007		
HP:0032668	biolink:PhenotypicFeature	Myoclonic status epilepticus without coma	A type of myoclonic status epilepticus in the absence of coma.		hp.json		http://purl.obolibrary.org/obo/HP_0032668		
HP:0007657	biolink:PhenotypicFeature	Diffuse nuclear cataract	Opacity of the entire lens nucleus.	UMLS:C4024821	hp.json		http://purl.obolibrary.org/obo/HP_0007657		
HP:0007651	biolink:PhenotypicFeature	Ectropion of lower eyelids		UMLS:C4020808|UMLS:C0521736|SNOMEDCT_US:95758006	hp.json	Lower eyelid folded out|Everted lower eyelids|Lower eyelid turned out	http://purl.obolibrary.org/obo/HP_0007651		
HP:0007654	biolink:PhenotypicFeature	obsolete Retinal striation			hp.json		http://purl.obolibrary.org/obo/HP_0007654		
HP:0007650	biolink:PhenotypicFeature	Progressive ophthalmoplegia		UMLS:C2062713	hp.json		http://purl.obolibrary.org/obo/HP_0007650		
UBERON:0003928	biolink:AnatomicalEntity	digestive system duct	A duct that is part of a digestive system [Automatically generated definition].	ZFA:0005162|TAO:0005162	hp.json	duct of digestive system|duct of gastrointestinal system|gastrointestinal system duct	http://purl.obolibrary.org/obo/UBERON_0003928		
UBERON:0003929	biolink:AnatomicalEntity	digestive tract epithelium	An epithelium that lines the lumen of the digestive tract.	MA:0003201|EHDAA2:0004567|ZFA:0005123|TAO:0005123|UMLS:C0836205|EMAPA:32928|BTO:0000956|NCIT:C12963|XAO:0003200	hp.json	gastrodermis|epithelium of digestive tract|epithelium of gut|epithelial tissue of digestive tract|alimentary tract epithelium|epithelial tissue of gut|gut epithelium|digestive tract epithelial tissue|gut epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003929		
HP:0005050	biolink:PhenotypicFeature	Anterolateral radial head dislocation	A dislocation of the head of the radius from its socket in the elbow joint in an anterolateral direction.	UMLS:C1968610	hp.json	Anterior/lateral radial head dislocation	http://purl.obolibrary.org/obo/HP_0005050		
UBERON:0003924	biolink:AnatomicalEntity	ventral pancreatic bud	Pancreatic bud that gives rise to the major pancreatic duct.	AAO:0011111|EFO:0003464|ZFA:0001369|XAO:0001103|TAO:0001369|EMAPA:17256|EHDAA2:0001389|VHOG:0001429	hp.json	pancreas ventral primordium duct bud|ventral pancreas anlage|pancreas primordium ventral bud|anterior pancreatic anlage|ventral pancreatic anlage|anterior pancreatic bud	http://purl.obolibrary.org/obo/UBERON_0003924		efo_slim|vertebrate_core
UBERON:0003922	biolink:AnatomicalEntity	pancreatic epithelial bud	The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID].	NCIT:C34242|EMAPA:35645|ZFA:0001390|TAO:0001390|UMLS:C1283285|EFO:0003470	hp.json	pancreas epithelium|pancreatic anlage|pancreatic bud|pancreatic buds	http://purl.obolibrary.org/obo/UBERON_0003922		efo_slim
UBERON:0003923	biolink:AnatomicalEntity	dorsal pancreatic bud	Pancreatic bud that gives rise to the accessory pancreatic duct.	ZFA:0001370|EHDAA2:0001385|EFO:0003465|AAO:0011031|TAO:0001370|XAO:0000467|EMAPA:17067|VHOG:0001428	hp.json	dorsal pancreas anlage|primary pancreatic bud|pancreas dorsal primordium duct bud|posterior pancreatic anlage|posterior pancreatic bud|pancreas primordium dorsal bud|dorsal pancreatic anlage	http://purl.obolibrary.org/obo/UBERON_0003923		efo_slim|vertebrate_core
HP:0005048	biolink:PhenotypicFeature	Synostosis of carpal bones		UMLS:C1836193	hp.json	Fusion of wrist bones	http://purl.obolibrary.org/obo/HP_0005048		
UBERON:0003931	biolink:AnatomicalEntity	diencephalic white matter	White matter that is part of a diencephalon [Automatically generated definition].	BIRNLEX:1678|ZFA:0000338|TAO:0000338|FMA:83931	hp.json	predominantly white regional part of diencephalon|diencephalic tracts and commissures|white matter of diencephalon|diencephalic tract/commissure	http://purl.obolibrary.org/obo/UBERON_0003931		vertebrate_core
UBERON:0003932	biolink:AnatomicalEntity	cartilage element of chondrocranium	A cartilage element of chondrocranium. Example: neurocranial trabecula.	EFO:0003690|ZFA:0001461|TAO:0001461	hp.json	neurocranium cartilage|cartilage of chondrocranium|chondrocranium cartilage|cartilaginous element of chondrocranium	http://purl.obolibrary.org/obo/UBERON_0003932		efo_slim
HP:0005045	biolink:PhenotypicFeature	Diaphyseal cortical sclerosis	An elevation in bone density of the cortex of one or more diaphyses. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C1833739	hp.json		http://purl.obolibrary.org/obo/HP_0005045		
UBERON:0003930	biolink:AnatomicalEntity	atrioventricular canal endocardium	Endocardium that is part of the atrioventricular canal[ZFA,vetted].	TAO:0002170|XAO:0004124|ZFA:0001616	hp.json	AVC endocardium|AV canal endocardium|endocardium of atrioventricular canal|endocardium of AV canal	http://purl.obolibrary.org/obo/UBERON_0003930		
HP:0005041	biolink:PhenotypicFeature	Irregular capital femoral epiphysis	Irregular surface of the normally relatively smooth capital femoral epiphysis.	UMLS:C4020825	hp.json	Irregular proximal femoral epiphyses|Irregular capital femoral epiphyses|Irregular end part of innermost thighbone	http://purl.obolibrary.org/obo/HP_0005041		
HP:0005042	biolink:PhenotypicFeature	Irregular, rachitic-like metaphyses		UMLS:C1866700	hp.json		http://purl.obolibrary.org/obo/HP_0005042		
HP:0005043	biolink:PhenotypicFeature	Proximal humeral metaphyseal irregularity	Irregularity of the normally smooth surface of the metaphysis at the proximal end of the humerus (at the shoulder).	UMLS:C1865128	hp.json	Irregular proximal humeral metaphyses	http://purl.obolibrary.org/obo/HP_0005043		
PATO:0001707	biolink:NamedThing	behavioural active	A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting marked activity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001707		value_slim
PATO:0001708	biolink:NamedThing	1-D extent	A size quality inhering in an bearer by virtue of the bearer's extension in one dimension.		hp.json	1-D size	http://purl.obolibrary.org/obo/PATO_0001708		attribute_slim
UBERON:0003918	biolink:AnatomicalEntity	kidney mesenchyme	Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO].		hp.json	mesenchyme of kidney	http://purl.obolibrary.org/obo/UBERON_0003918		pheno_slim|human_reference_atlas
UBERON:0003915	biolink:AnatomicalEntity	endothelial tube	Any endothelium that has the quality of being cylindrical [Automatically generated definition].		hp.json		http://purl.obolibrary.org/obo/UBERON_0003915		
HP:0005060	biolink:PhenotypicFeature	Limited elbow flexion/extension		UMLS:C1968605	hp.json		http://purl.obolibrary.org/obo/HP_0005060		
UBERON:0003916	biolink:AnatomicalEntity	fat pad	A mass of closely packed fat cells (adipose tissue) surrounded by fibrous tissue septa[TMD].	FMA:58616|BTO:0000444|MA:0002481|EMAPA:35340	hp.json	fat body	http://purl.obolibrary.org/obo/UBERON_0003916		pheno_slim
UBERON:0003913	biolink:AnatomicalEntity	tooth-like structure	Hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.	HAO:0001019	hp.json	tooth-like organ	http://purl.obolibrary.org/obo/UBERON_0003913		grouping_class
UBERON:0003914	biolink:AnatomicalEntity	epithelial tube	Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.	EHDAA2:0003114|FBbt:00007474|AEO:0000114	hp.json	epithelial or endothelial tube	http://purl.obolibrary.org/obo/UBERON_0003914		
UBERON:0003911	biolink:AnatomicalEntity	choroid plexus epithelium	The epithelial component of the choroid plexus. Consists of cuboidal epithelial cells surrounding a core of capillaries and loose connective tissue.	FMA:242811|MA:0000824|UMLS:C1516506|NCIT:C42079|EMAPA:36608	hp.json	choroid plexus epithelial tissue|epithelium of choroid plexus|epithelial tissue of choroid plexus|epithelial tissue of chorioid plexus of cerebral hemisphere	http://purl.obolibrary.org/obo/UBERON_0003911		
HP:0032605	biolink:PhenotypicFeature	High renal tubular epithelial cell N/C ratio	At least one tubular epithelial cell with average sized cytoplasmic area and a nuclear area 3 times greater than average sized nuclei.		hp.json	High N/C ratio of renal tubular epithelial cells	http://purl.obolibrary.org/obo/HP_0032605		
HP:0032604	biolink:PhenotypicFeature	Renal tubular epithelial cell mitosis	Tubular epithelial cells in any mitotic phase, identified by distinctively visible chromosome in either prophase, metaphase, anaphase or telophase configuration.		hp.json		http://purl.obolibrary.org/obo/HP_0032604		
HP:0032607	biolink:PhenotypicFeature	Renal tubular epithelial cell swelling	Tubular cross section lined entirely by tubular epithelium with convex apical cell membrane (i.e., cells are shaped like an upside down U, and lack a distinct smaller protrusion seen in blebbing as defined above) resulting in apparent complete closure of the lumen.		hp.json		http://purl.obolibrary.org/obo/HP_0032607		
PR:P55097	biolink:Protein	cathepsin K (mouse)	A cathepsin K that is encoded in the genome of mouse.	UniProtKB:P55097	hp.json	Ctsk|mCTSK	http://purl.obolibrary.org/obo/PR_P55097		
HP:0032606	biolink:PhenotypicFeature	Renal tubular epithelial lipofuscin	Presence of increased amount of lipofuscin, a yellow, granular cytoplasmic pigment in the renal tubules.		hp.json		http://purl.obolibrary.org/obo/HP_0032606		
CHEBI:58163	biolink:ChemicalSubstance	homocystine zwitterion	Dizwitterionic form of homocystine arising from transfer of two protons from the carboxy to the amino groups; major species at pH 7.3.		hp.json	4,4'-disulfanediylbis(2-azaniumylbutanoate)|homocystine dizwitterion|4,4'-disulfanediylbis(2-ammoniobutanoate)	http://purl.obolibrary.org/obo/CHEBI_58163		3_STAR
HP:0005059	biolink:PhenotypicFeature	Arthralgia/arthritis		UMLS:C4025256	hp.json	Joint pain/Joint inflammation	http://purl.obolibrary.org/obo/HP_0005059		
HP:0032601	biolink:PhenotypicFeature	Multinucleation of renal tubular epithelial cells	Tubular epithelial cells with greater than 3 nuclei in a single epithelial cell, often overlapping with each other in a single plane of view.		hp.json		http://purl.obolibrary.org/obo/HP_0032601		
HP:0032600	biolink:PhenotypicFeature	Renal tubular epithelial cell hyaline droplets	Tubular epithelium with round strongly PAS-positive cytoplasmic droplet material in at least one tubular epithelial cell.		hp.json		http://purl.obolibrary.org/obo/HP_0032600		
HP:0032603	biolink:PhenotypicFeature	Renal tubular epithelial cell simplification	Tubular cross section with flattened tubular cell cytoplasm (height unequivocally less than width), with complete loss of brush border involving greater than 50 percent of the tubular cells in cross section, resulting in an apparent increase in the size of the lumen, without the presence of casts.		hp.json		http://purl.obolibrary.org/obo/HP_0032603		
HP:0032602	biolink:PhenotypicFeature	Prominent nucleoli of renal tubular epithelial cells	Tubular epithelium with nucleoli clearly visible at 100-fold magnification.		hp.json		http://purl.obolibrary.org/obo/HP_0032602		
UBERON:0003920	biolink:AnatomicalEntity	venous blood vessel	A blood vessel that carries blood from the capillaries toward the heart.	FMA:86188|MA:0000066|EMAPA:35932	hp.json	segment of venous tree organ|venous tree organ segment	http://purl.obolibrary.org/obo/UBERON_0003920		
UBERON:0003921	biolink:AnatomicalEntity	pancreas primordium	Embryonic structure that develops into pancreatic bud.	EFO:0003434|EHDAA:2163|EHDAA2:0001382|FMA:79792|XAO:0001101|ZFA:0000254|EMAPA:17066|TAO:0000254|EFO:0002579	hp.json	primordial pancreas|pancreatic primordium|pancreatic endoderm|pancreatic anlage	http://purl.obolibrary.org/obo/UBERON_0003921		efo_slim|vertebrate_core
HP:0032609	biolink:PhenotypicFeature	Endocrine-type tubular atrophy	A type of renal tubular atrophy characterized by endocrine-like appearance of tubules, which are small and have narrow lumina, clear cells, and relatively thin basement membranes.		hp.json	Endocrinization pattern of tubular atrophy|Renal tubular atrophy, endocrine-type	http://purl.obolibrary.org/obo/HP_0032609		
HP:0032608	biolink:PhenotypicFeature	Thyroidization-type tubular atrophy	A type of renal tubular atrophy characterized by a thyroid-like appearance, with small round tubules with markedly flattened, simplified epithelium and uniform intratubular casts.		hp.json		http://purl.obolibrary.org/obo/HP_0032608		
HP:0005054	biolink:PhenotypicFeature	Metaphyseal spurs	Bony outgrowths that extend laterally from the margin of the metaphysis.	UMLS:C1832988	hp.json		http://purl.obolibrary.org/obo/HP_0005054		
UBERON:0003907	biolink:AnatomicalEntity	left atrioventricular canal	An atrioventricular canal that is in the left side of a atrioventricular region.	EHDAA:5336|FMA:71123|EHDAA2:0000935	hp.json	left atrio-ventricular canal|left AVC	http://purl.obolibrary.org/obo/UBERON_0003907		
HP:0007690	biolink:PhenotypicFeature	Map-dot-fingerprint corneal dystrophy		SNOMEDCT_US:32935005|UMLS:C0271285	hp.json		http://purl.obolibrary.org/obo/HP_0007690		
UBERON:0003902	biolink:AnatomicalEntity	retinal neural layer	The part of the retina that contains neurons and photoreceptor cells[GO].	TAO:0000046|EHDAA:4763|FMA:58628|NCIT:C33166|VHOG:0000535|EHDAA2:0001253|EMAPA:18590|EMAPA:17171|UMLS:C1518263|BTO:0000929|CALOHA:TS-0685|AAO:0011095|XAO:0003216|ZFA:0000046|MA:0000277	hp.json	neuroretina|neural retinal epithelium|neural retina|stratum nervosum (retina)|stratum nervosum retinae|neural layer of retina	http://purl.obolibrary.org/obo/UBERON_0003902		pheno_slim|vertebrate_core
UBERON:0003900	biolink:AnatomicalEntity	epaxial myotome region	Portion of myotome that is dorsal to the horizontal septum.	ZFA:0001084|TAO:0001084	hp.json	epaxial myotome regions	http://purl.obolibrary.org/obo/UBERON_0003900		
UBERON:0003901	biolink:AnatomicalEntity	horizontal septum	A logitudinal sheet of continuous connective tissue partition developing at the apex of the chevron-shaped myotome and separating dorsal (epaxial) and ventral (hypaxial) body wall muscle masses; each is destined to become, respectively, the epaxial and hyopaxial musculature.	TAO:0000671|EFO:0003555|ZFA:0000671	hp.json	horizontal septum of vertebra|horizontal myoseptum	http://purl.obolibrary.org/obo/UBERON_0003901		efo_slim
PATO:0001710	biolink:NamedThing	3-D extent	A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions.		hp.json	3D size	http://purl.obolibrary.org/obo/PATO_0001710		attribute_slim
HGNC:317	biolink:Gene	AFP (human)	A protein coding gene AFP in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=317		
PATO:0001711	biolink:NamedThing	perimeter	An 1-D extent quality inhering in two-dimensional bearer by virtue of being equal to the distance around it.		hp.json		http://purl.obolibrary.org/obo/PATO_0001711		scalar_slim|attribute_slim
HP:0032610	biolink:PhenotypicFeature	Tubulointerstitial mycobacterial infiltration	Renal tubulointerstitial infiltration of mycobacteria identified on acid-fast or Fite stains. Can be associated with granulomatous inflammation.		hp.json	Renal tubulointerstitial mycobacterial organisms	http://purl.obolibrary.org/obo/HP_0032610		
PATO:0001714	biolink:NamedThing	increased diameter	A diameter which is relatively large.		hp.json		http://purl.obolibrary.org/obo/PATO_0001714		value_slim
PATO:0001715	biolink:NamedThing	decreased diameter	A diameter which is relatively small.		hp.json		http://purl.obolibrary.org/obo/PATO_0001715		value_slim
UBERON:0003908	biolink:AnatomicalEntity	right atrioventricular canal	An atrioventricular canal that is in the right side of a atrioventricular region.	EHDAA:5338|FMA:71122|EHDAA2:0001719	hp.json	right AVC|right atrio-ventricular canal	http://purl.obolibrary.org/obo/UBERON_0003908		
PATO:0001712	biolink:NamedThing	increased perimeter	A perimeter which is relatively high.		hp.json		http://purl.obolibrary.org/obo/PATO_0001712		value_slim
UBERON:0003909	biolink:AnatomicalEntity	sinusoid	Small blood vessel similar to a capillary but with a fenestrated endothelium. Sinusoids are found in the liver, lymphoid tissue, endocrine organs, and hematopoietic organs such as the bone marrow and the spleen. Sinusoids found within terminal villi of the placenta are not comparable to these; they possess a continuous endothelium and complete basal lamina[WP].	SCTID:340163004|ZFA:0005261|FMA:63131|TAO:0005261|Wikipedia:Sinusoid_(blood_vessel)	hp.json	sinusoidal blood vessel endothelium|sinusoidal blood vessel|sinusoidal endothelium|sinusoidal capillary|endothelium of irregular blood filled space|sinusoidal capillary	http://purl.obolibrary.org/obo/UBERON_0003909		vertebrate_core
PATO:0001713	biolink:NamedThing	decreased perimeter	A perimeter which is relatively low.		hp.json		http://purl.obolibrary.org/obo/PATO_0001713		value_slim
HP:0032616	biolink:PhenotypicFeature	Renal interstitial immunoglobulin deposits	Accumulation of an immunoglobulin in the interstitial tissue of the kidney. The immunoglobulin may be a monoclonal Ig or the corresponding heavy-chain (HC) or light-chain (LC) subunit. By convention this definition excludes Ig-derived amyloidosis (amyloidosis can be distinguished by its affinity for Congo red staining).		hp.json	Renal interstitial immunoglobulin deposition	http://purl.obolibrary.org/obo/HP_0032616		
HP:0032615	biolink:PhenotypicFeature	Abnormal diffusion weighted cerebral MRI morphology	A diffusion abnormality observed in diffusion-weighted magnetic resonance imaging (MRI) of the brain. Molecular diffusion refers to the notion that any type of molecule in a fluid (eg, water) is randomly displaced as the molecule is agitated by thermal energy. Restricted diffusion of water appears bright on diffusion-weighted images.		hp.json	MRI diffusion abnormality of the cerebrum|Diffusion weighted imaging (DWI) abnormality|Diffusion weighted magnetic resonance imaging (DWI) abnormality	http://purl.obolibrary.org/obo/HP_0032615		
HP:0032618	biolink:PhenotypicFeature	Renal necrosis	Cell death (necrosis) affecting one or more parts of the kidney.		hp.json	Renal parenchymal necrosis	http://purl.obolibrary.org/obo/HP_0032618		
HP:0032617	biolink:PhenotypicFeature	Renal interstitial hemorrhage	A focal collection of 20 or more red blood cells within the interstitium, that is irregular in shape (i.e., collections do not conform to the shape of tubules or capillary networks), without surrounding endothelium or tubular epithelium, and is in an area of intact core.		hp.json	Renal interstitial haemorrhage	http://purl.obolibrary.org/obo/HP_0032617		
HP:0032612	biolink:PhenotypicFeature	Triphalangeal hallux	A hallux (big toe) with three phalanges in a single, proximo-distal axis.		hp.json		http://purl.obolibrary.org/obo/HP_0032612		
HP:0005026	biolink:PhenotypicFeature	Mesomelic/rhizomelic limb shortening		UMLS:C1866239	hp.json		http://purl.obolibrary.org/obo/HP_0005026		
HP:0032611	biolink:PhenotypicFeature	Renal tubular epithelial cell hemosiderin	Tubular epithelial cells containing cytoplasmic hemosiderin, brown-golden granular pigment.		hp.json		http://purl.obolibrary.org/obo/HP_0032611		
HP:0007688	biolink:PhenotypicFeature	Undetectable light- and dark-adapted electroretinogram	Absence of the combined rod-and-cone response on electroretinogram.	UMLS:C4021570	hp.json	Absent rod-and cone-mediated responses on ERG|Absent cone and rod functions by electroretinogram	http://purl.obolibrary.org/obo/HP_0007688		
HP:0005028	biolink:PhenotypicFeature	Widened proximal tibial metaphyses		UMLS:C1836187	hp.json	Wide innermost wide portion of shinbone bone|Wide innermost wide portion of shankbone bone	http://purl.obolibrary.org/obo/HP_0005028		
HP:0032614	biolink:PhenotypicFeature	Renal glomerular amyloid deposition	Amyloid deposits located in the glomeruli in a focal segmental, diffuse segmental or diffuse global fashion. This abnormality can be accompanied by mesangial involvement and in later stages also involvement of the peripheral capillaries.		hp.json		http://purl.obolibrary.org/obo/HP_0032614		
HP:0032613	biolink:PhenotypicFeature	Renal interstitial amyloid deposits	Deposition of amyloid in the interstitial tissue of the kidney. Amyloid is is made up of 10 nm (on average) fibrils that are most commonly composed of monoclonal light chains (AL), transthyretin (TTR), amd LECT2, or occur in the setting of long standing systemic inflammation.		hp.json	Renal interstitial amyloid|Renal interstitial amyloidosis|Renal interstitial amyloid deposition	http://purl.obolibrary.org/obo/HP_0032613		
HP:0007685	biolink:PhenotypicFeature	Peripheral retinal avascularization		UMLS:C1851406	hp.json		http://purl.obolibrary.org/obo/HP_0007685		
HP:0007687	biolink:PhenotypicFeature	Unilateral ptosis	A unilateral form of ptosis.	UMLS:C1866806	hp.json	Dropping of one upper eyelid	http://purl.obolibrary.org/obo/HP_0007687		
HP:0007686	biolink:PhenotypicFeature	Abnormal pupillary function	A functional abnormality of the pupil.	UMLS:C0917967|SNOMEDCT_US:72124005|MSH:D011681	hp.json		http://purl.obolibrary.org/obo/HP_0007686		
HP:0005025	biolink:PhenotypicFeature	Hypoplastic distal humeri	Underdevelopment of the distal portion of the humerus.	UMLS:C1968607	hp.json		http://purl.obolibrary.org/obo/HP_0005025		
HP:0032619	biolink:PhenotypicFeature	Perinephric abscess	A perinephric abscess is a collection of suppurative material in the perinephric space (i.e., the connective and adipose tissues surrounding the kidney).		hp.json		http://purl.obolibrary.org/obo/HP_0032619		
HP:0007680	biolink:PhenotypicFeature	Depigmented fundus		UMLS:C4024816	hp.json		http://purl.obolibrary.org/obo/HP_0007680		
HP:0005021	biolink:PhenotypicFeature	Bilateral elbow dislocations		UMLS:C3278429	hp.json	Dislocated elbows on both sides	http://purl.obolibrary.org/obo/HP_0005021		
HP:0032621	biolink:PhenotypicFeature	Hyperchromasia of renal tubular epithelial cells	At least one tubular cross section with all tubular epithelial nuclei having a chromatin pattern resembling normal mature lymphocytes.		hp.json	Condensed chromatin of renal tubular epithelial cells	http://purl.obolibrary.org/obo/HP_0032621		
HP:0032620	biolink:PhenotypicFeature	Intrarenal abscess	An encapsulated collection of pus and necrotic material within the renal parenchyma. The destruction of renal parenchyma is associated with suppurative/neutrophil-rich inflammation and necrosis.		hp.json	Renal parenchymal abcess|Renal abscess	http://purl.obolibrary.org/obo/HP_0032620		
HP:0032627	biolink:PhenotypicFeature	Intratubular leukocyte casts	Casts that contain white blood cells and are located within the tubuli of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032627		
HP:0032626	biolink:PhenotypicFeature	Intratubular vancomycin casts	Intratubular casts composed of vancomycin aggregates and uromodulin.		hp.json		http://purl.obolibrary.org/obo/HP_0032626		
PR:P55075	biolink:Protein	fibroblast growth factor 8 (human)	A fibroblast growth factor 8 that is encoded in the genome of human.	UniProtKB:P55075	hp.json	HBGF-8 (human)|heparin-binding growth factor 8 (human)|AIGF|androgen-induced growth factor (human)|hFGF8|FGF8|FGF-8 (human)	http://purl.obolibrary.org/obo/PR_P55075		
HP:0032629	biolink:PhenotypicFeature	Intratubular dihydroxyadenuria crystals	Intratubular crystals composed of 2,8-dihydroxyadenine are small needle-shaped brownish crystals that are highly birefringent under polarized light and black by Jones methenamine silver.		hp.json		http://purl.obolibrary.org/obo/HP_0032629		
HP:0032628	biolink:PhenotypicFeature	Renal intratubular crystals			hp.json		http://purl.obolibrary.org/obo/HP_0032628		
HP:0032623	biolink:PhenotypicFeature	Renal intratubular casts	Urinary casts are formed in the distal convoluted tubule or the collecting duct by solidification of protein in the lumen of the kidney tubules. This term refers to casts located within the tubuli of the kidney. More precisely, casts are defined as a material that completely fills and expands the tubular lumen with simplification of surrounding tubular epithelium. Casts are classified as either nuclear debris/granular brown material, red blood cell, white blood cell, myeloma, or myoglobin cast.		hp.json	Tubular casts	http://purl.obolibrary.org/obo/HP_0032623		
HP:0005037	biolink:PhenotypicFeature	Proximal radio-ulnar synostosis	An abnormal osseous union (fusion) between the proximal portions of the radius and the ulna.	UMLS:C2676443	hp.json		http://purl.obolibrary.org/obo/HP_0005037		
HP:0032622	biolink:PhenotypicFeature	Tubular luminal dilatation	Dilatation (expansion beyond the normal dimension) of the cavity (lumen) of tubules of the kidney. The tubular cross section displays an attenuated brush border (apical PAS positivity greater than 10 percent of the normal expected height, but unequivocally less than normal expected height), resulting in an apparent increase in the size of lumen.		hp.json	Tubular ectasia	http://purl.obolibrary.org/obo/HP_0032622		
HP:0005039	biolink:PhenotypicFeature	Multiple long-bone exostoses	Multiple exostoses originating in long bones.	UMLS:C1835583	hp.json	Multiple exostoses of long tubular bones	http://purl.obolibrary.org/obo/HP_0005039		
HP:0032625	biolink:PhenotypicFeature	Intratubular erythrocyte cast	Casts that contain red blood cells and are located within the tubuli of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032625		
HP:0032624	biolink:PhenotypicFeature	Intratubular bilirubin casts	A type of acelluar intratubular casts that have a surface composed of granules, which can vary in size. On H&E (red brown), PAS (amaranth purple), trichrome (red with ragged contours), Hall (olive-emerald green).		hp.json		http://purl.obolibrary.org/obo/HP_0032624		
HP:0005033	biolink:PhenotypicFeature	Distal ulnar hypoplasia	Underdevelopment of the distal portion of the ulna.	UMLS:C1833145	hp.json	Distal shortening of ulna|Hypoplastic distal ulna	http://purl.obolibrary.org/obo/HP_0005033		
HP:0007695	biolink:PhenotypicFeature	Abnormal pupillary light reflex	An abnormality of the reflex that controls the diameter of the pupil, in response to the intensity of light that falls on the retina of the eye.	UMLS:C1970591	hp.json		http://purl.obolibrary.org/obo/HP_0007695		
HP:0005035	biolink:PhenotypicFeature	Shortening of all phalanges of the toes	Developmental hypoplasia (shortening) of all phalanges of the foot.	UMLS:C4025257	hp.json	Short toe bones	http://purl.obolibrary.org/obo/HP_0005035		
HP:0007698	biolink:PhenotypicFeature	obsolete Retinal pigment epithelial atrophy			hp.json		http://purl.obolibrary.org/obo/HP_0007698		
HP:0007697	biolink:PhenotypicFeature	Hypoplasia of the lower eyelids	Underdevelopment of the lower eyelid.	UMLS:C4280420|UMLS:C4280270|UMLS:C4024814	hp.json	Decreased size of lower eyelid|Small lower eyelid|Underdevelopment of lower eyelid|Hypotrophic lower eyelid|Short lower eyelid	http://purl.obolibrary.org/obo/HP_0007697		
HP:0005036	biolink:PhenotypicFeature	Unilateral ulnar hypoplasia	Underdevelopment of the ulna on only one side.	UMLS:C1837832	hp.json		http://purl.obolibrary.org/obo/HP_0005036		
HP:0007692	biolink:PhenotypicFeature	obsolete Nonnuclear polymorphic congenital cataract			hp.json		http://purl.obolibrary.org/obo/HP_0007692		
HP:0007691	biolink:PhenotypicFeature	obsolete Short curly eyelashes			hp.json		http://purl.obolibrary.org/obo/HP_0007691		
GO:0047496	biolink:BiologicalProcess	vesicle transport along microtubule	The directed movement of a vesicle along a microtubule, mediated by motor proteins. This process begins with the attachment of a vesicle to a microtubule, and ends when the vesicle reaches its final destination.		hp.json	microtubule-based vesicle localization	http://purl.obolibrary.org/obo/GO_0047496		
GO:1901568	biolink:BiologicalProcess	fatty acid derivative metabolic process	The chemical reactions and pathways involving fatty acid derivative.		hp.json	fatty acid derivative metabolism	http://purl.obolibrary.org/obo/GO_1901568		
GO:1901566	biolink:BiologicalProcess	organonitrogen compound biosynthetic process	The chemical reactions and pathways resulting in the formation of organonitrogen compound.		hp.json	organonitrogen compound anabolism|organonitrogen compound biosynthesis|organonitrogen compound synthesis|organonitrogen compound formation	http://purl.obolibrary.org/obo/GO_1901566		
GO:1901564	biolink:BiologicalProcess	organonitrogen compound metabolic process	The chemical reactions and pathways involving organonitrogen compound.		hp.json	organonitrogen compound metabolism	http://purl.obolibrary.org/obo/GO_1901564		
GO:1901570	biolink:BiologicalProcess	fatty acid derivative biosynthetic process	The chemical reactions and pathways resulting in the formation of fatty acid derivative.		hp.json	fatty acid derivative biosynthesis|fatty acid derivative anabolism|fatty acid derivative synthesis|fatty acid derivative formation	http://purl.obolibrary.org/obo/GO_1901570		
GO:0060474	biolink:NamedThing	positive regulation of flagellated sperm motility involved in capacitation			hp.json		http://purl.obolibrary.org/obo/GO_0060474		
GO:0060479	biolink:BiologicalProcess	lung cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features of a mature cell found in the lung. Differentiation includes the processes involved in commitment of a cell to a specific fate.		hp.json	pulmonary cell differentiation	http://purl.obolibrary.org/obo/GO_0060479		
GO:1901576	biolink:BiologicalProcess	organic substance biosynthetic process	The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon.		hp.json	organic molecular entity formation|organic molecular entity biosynthesis|organic molecular entity biosynthetic process|organic substance anabolism|organic substance biosynthesis|organic molecular entity anabolism|organic substance synthesis|organic molecular entity synthesis|organic substance formation	http://purl.obolibrary.org/obo/GO_1901576		
GO:1901575	biolink:BiologicalProcess	organic substance catabolic process	The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon.		hp.json	organic molecular entity breakdown|organic molecular entity catabolism|organic molecular entity catabolic process|organic substance catabolism|organic substance degradation|organic molecular entity degradation|organic substance breakdown	http://purl.obolibrary.org/obo/GO_1901575		
GO:0060460	biolink:BiologicalProcess	left lung morphogenesis	The process in which anatomical structures of the left lung are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060460		
GO:0060461	biolink:BiologicalProcess	right lung morphogenesis	The process in which anatomical structures of the right lung are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060461		
GO:0060462	biolink:BiologicalProcess	lung lobe development	The biological process whose specific outcome is the progression of a lung lobe from an initial condition to its mature state. This process begins with the formation of a lung lobe by branching morphogenesis and ends with the mature structure. A lung lobe is one of the rounded projections that compose the lung.		hp.json		http://purl.obolibrary.org/obo/GO_0060462		
GO:0060463	biolink:BiologicalProcess	lung lobe morphogenesis	The process in which the anatomical structures of a lung lobe are generated and organized. A lung lobe is a projection that extends from the lung.		hp.json		http://purl.obolibrary.org/obo/GO_0060463		
GO:0060464	biolink:BiologicalProcess	lung lobe formation	The developmental process pertaining to the initial formation of a lung lobe from unspecified parts. This process begins with the specific processes that contribute to the appearance of the lobe and ends when the structural rudiment is recognizable. A lung lobe is a projection that extends from the lung.		hp.json		http://purl.obolibrary.org/obo/GO_0060464		
GO:0060465	biolink:BiologicalProcess	pharynx development	The biological process whose specific outcome is the progression of a pharynx from an initial condition to its mature state. The pharynx is the part of the digestive system immediately posterior to the mouth.		hp.json	pharyngeal development	http://purl.obolibrary.org/obo/GO_0060465		
GO:0060467	biolink:BiologicalProcess	negative regulation of fertilization	Any process that decreases the rate, frequency or extent of fertilization. Fertilization is the union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).		hp.json		http://purl.obolibrary.org/obo/GO_0060467		
GO:0060468	biolink:BiologicalProcess	prevention of polyspermy	The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg.		hp.json	negative regulation of fertilization involved in egg activation|polyspermy block	http://purl.obolibrary.org/obo/GO_0060468		
GO:1901589	biolink:CellularComponent	axon microtubule bundle	An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment.	NIF_Subcellular:sao707332678	hp.json	axon microtubule fascicle|microtubule bundle of axon|microtubule fascicle of axon	http://purl.obolibrary.org/obo/GO_1901589		
GO:0060491	biolink:BiologicalProcess	regulation of cell projection assembly	Any process that modulates the rate, frequency, or extent of cell projection assembly.		hp.json	regulation of cell projection formation	http://purl.obolibrary.org/obo/GO_0060491		
GO:0060495	biolink:BiologicalProcess	cell-cell signaling involved in lung development	Any process that mediates the transfer of information from one cell to another and contributes to the progression of the lung, from its initial state to the mature structure.		hp.json	cell-cell signalling involved in lung development	http://purl.obolibrary.org/obo/GO_0060495		
GO:0060485	biolink:BiologicalProcess	mesenchyme development	The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.		hp.json	mesenchymal development	http://purl.obolibrary.org/obo/GO_0060485		
GO:0060487	biolink:BiologicalProcess	lung epithelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell that contributes to the epithelium of the lung.		hp.json	pulmonary epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0060487		
NCBITaxon:2301119	biolink:OrganismalEntity	Rhabditomorpha		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_2301119		
NCBITaxon:2301116	biolink:OrganismalEntity	Rhabditina		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_2301116		
HP:0007627	biolink:PhenotypicFeature	Mandibular condyle aplasia		SNOMEDCT_US:235119009|UMLS:C4280429|UMLS:C4280437|UMLS:C4280436|UMLS:C4280435|UMLS:C4280434|UMLS:C4280433|UMLS:C4280432|UMLS:C4280431|UMLS:C0399570|UMLS:C4280430	hp.json	Underdevelopment of condylar head of mandible|Underdevelopment of condylar neck of mandible|Agenesis of condylar process of mandible|Underdevelopment of condylar process of mandible|Absence of the condylar process of mandible|Failure of development of condylar head of mandible|Failure of development of condylar neck of mandible|Failure of development of the condylar process of mandible|Absence of the condylar head of mandible|Absence of the condylar neck of mandible|Agenesis of condylar head of mandible|Agenesis of condylar neck of mandible	http://purl.obolibrary.org/obo/HP_0007627		
HP:0007626	biolink:PhenotypicFeature	Mandibular osteomyelitis	Osteomyelitis of the lower jaw.	UMLS:C1290708|SNOMEDCT_US:109695005	hp.json	Lower jaw bone infection|Osteomyelitis, especially of the mandible	http://purl.obolibrary.org/obo/HP_0007626		
HP:0007628	biolink:PhenotypicFeature	Mandibular condyle hypoplasia		UMLS:C4280428|UMLS:C4280427|UMLS:C4280426|UMLS:C4280425|UMLS:C4280424|UMLS:C4280423|UMLS:C0399572|SNOMEDCT_US:235120003	hp.json	Hypoplasia of condylar process of mandible|Hypoplasia of condylar head of mandible|Hypoplasia of condylar neck of mandible|Small mandibular condyle|Hypotrophic mandibular condyle|Hypoplasia of subcondylar region of mandible|Hypotrophic condylar process of mandible|Decreased size of mandibular condyle|Decreased size of condylar process of mandible|Small condylar head of mandible|Hypoplasia of mandibular condyle|Small condylar neck of mandible	http://purl.obolibrary.org/obo/HP_0007628		
HP:0007623	biolink:PhenotypicFeature	Pigmentation anomalies of sun-exposed skin		UMLS:C4024826	hp.json	Abnormal pigmentation in sun-exposed skin	http://purl.obolibrary.org/obo/HP_0007623		
HP:0007621	biolink:PhenotypicFeature	Telangiectasia of extensor surfaces		UMLS:C4024827	hp.json		http://purl.obolibrary.org/obo/HP_0007621		
HP:0007620	biolink:PhenotypicFeature	Cutaneous leiomyoma	The presence of leiomyoma of the skin.	SNOMEDCT_US:254767008|NCIT:C3157|UMLS:C0346064	hp.json	Cutaneous leiomyomata|Cutaneous leiomyomas	http://purl.obolibrary.org/obo/HP_0007620		
HP:0007634	biolink:PhenotypicFeature	Nonarteritic anterior ischemic optic neuropathy	An acute condition characterized by sudden visual loss (usually discovered in the morning), optic disc edema at onset, optic disc-related visual field defects. Nonarteritic anterior ischemic optic neuropathy can be associated with flame hemorrhages on the swollen disc or nearby neuroretinal layer, and sometimes with nearby cotton-wool exudates.	UMLS:C1852242	hp.json	Nonarteritic anterior ischaemic optic neuropathy	http://purl.obolibrary.org/obo/HP_0007634		
HP:0007633	biolink:PhenotypicFeature	Bilateral microphthalmos	A developmental anomaly characterized by abnormal smallness of both eyes.	UMLS:C4280422|UMLS:C4280421|UMLS:C1843496	hp.json	Bilateral nanophthalmos|Decreased size of globes of eyes|Decreased size of eyeballs|Abnormally small eyeball on both sides|Microphthalmia, bilateral	http://purl.obolibrary.org/obo/HP_0007633		
GO:0072488	biolink:BiologicalProcess	ammonium transmembrane transport	The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+.		hp.json	ammonium transport|ammonium membrane transport|ammonia transport	http://purl.obolibrary.org/obo/GO_0072488		
HP:0007609	biolink:PhenotypicFeature	Hypoproteinemic edema	An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body because of decreased osmotic pressure of plasma (hypoproteinemia).	UMLS:C4024832	hp.json	Hypoproteinemic oedema	http://purl.obolibrary.org/obo/HP_0007609		
HP:0007608	biolink:PhenotypicFeature	Abnormal palmar dermal ridges		UMLS:C4024833	hp.json		http://purl.obolibrary.org/obo/HP_0007608		
GO:0035441	biolink:BiologicalProcess	cell migration involved in vasculogenesis	The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.		hp.json		http://purl.obolibrary.org/obo/GO_0035441		
HP:0007605	biolink:PhenotypicFeature	Excessive wrinkling of palmar skin		UMLS:C4021572	hp.json	Redundant, wrinkled skin of palms	http://purl.obolibrary.org/obo/HP_0007605		
HP:0007607	biolink:PhenotypicFeature	Hypohidrotic ectodermal dysplasia		MSH:D053358|UMLS:C0162359|SNOMEDCT_US:7731005|SNOMEDCT_US:239007005	hp.json		http://purl.obolibrary.org/obo/HP_0007607		
HP:0007606	biolink:PhenotypicFeature	Multiple cutaneous malignancies		UMLS:C4024834	hp.json		http://purl.obolibrary.org/obo/HP_0007606		
HP:0007601	biolink:PhenotypicFeature	Midline facial capillary hemangioma		UMLS:C1840310	hp.json		http://purl.obolibrary.org/obo/HP_0007601		
HP:0007603	biolink:PhenotypicFeature	Freckles in sun-exposed areas		UMLS:C1859923	hp.json	Freckles in sun-exposed areas	http://purl.obolibrary.org/obo/HP_0007603		
HP:0007602	biolink:PhenotypicFeature	Complex palmar dermatoglyphic pattern		UMLS:C4024835	hp.json		http://purl.obolibrary.org/obo/HP_0007602		
HP:0007616	biolink:PhenotypicFeature	Nevus flammeus nuchae	Naevus flammeus localised in the skin of the neck. This is one of the most common birthmarks and present in approximately 25% of all newborns.	UMLS:C0860468|UMLS:C4280438|UMLS:C4024829	hp.json	Angel's kiss|Port-wine stain on neck|Stork bite|Salmon patch	http://purl.obolibrary.org/obo/HP_0007616		
HP:0007618	biolink:PhenotypicFeature	Subcutaneous calcification	Deposition of calcium salts in subcutaneous tissue (i.e., the the lowermost layer of the integument).	UMLS:C0263625|SNOMEDCT_US:17141001	hp.json	Skin calcification	http://purl.obolibrary.org/obo/HP_0007618		hposlim_core
HP:0007617	biolink:PhenotypicFeature	Fine, reticulate skin pigmentation		UMLS:C4024828	hp.json		http://purl.obolibrary.org/obo/HP_0007617		
GO:0035435	biolink:BiologicalProcess	phosphate ion transmembrane transport	The process in which a phosphate is transported across a membrane.		hp.json	phosphate ion membrane transport	http://purl.obolibrary.org/obo/GO_0035435		
HP:0007613	biolink:PhenotypicFeature	Spinous keratoses of palms and soles		UMLS:C4024830	hp.json		http://purl.obolibrary.org/obo/HP_0007613		
HP:0007610	biolink:PhenotypicFeature	Blotching pigmentation of the skin		UMLS:C4024831	hp.json		http://purl.obolibrary.org/obo/HP_0007610		
CHEBI:83057	biolink:ChemicalSubstance	Daphnia metabolite	A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia	Wikipedia:Daphnia	hp.json	Daphnia metabolites	http://purl.obolibrary.org/obo/CHEBI_83057		3_STAR
CHEBI:83056	biolink:ChemicalSubstance	Daphnia magna metabolite	A Daphnia metabolite produced by the species Daphnia magna.		hp.json	Daphnia magna metabolites	http://purl.obolibrary.org/obo/CHEBI_83056		3_STAR
UBERON:0001394	biolink:AnatomicalEntity	axillary artery	Artery that supplies the axilla.	galen:AxillaryArtery|NCIT:C32169|GAID:473|UMLS:C0004455|MESH:D001366|MA:0002573|OpenCyc:Mx4rwRh-vZwpEbGdrcN5Y29ycA|FMA:22654|EMAPA:18749	hp.json	arteria axillaris|axillary part of trunk of subclavian artery|axillary part of subclavian artery	http://purl.obolibrary.org/obo/UBERON_0001394		uberon_slim|human_reference_atlas
CHEBI:12777	biolink:ChemicalSubstance	vitamin A	Any member of a group of fat-soluble retinoids produced via metabolism of provitamin A carotenoids that exhibit biological activity against vitamin A deficiency. Vitamin A is involved in immune function, vision, reproduction, and cellular communication.	MetaCyc:Vitamin-A|Wikipedia:Vitamin_A	hp.json	vitamin-A|vitamin A vitamers|vitamins A|vitamin A vitamer	http://purl.obolibrary.org/obo/CHEBI_12777		3_STAR
UBERON:0001397	biolink:AnatomicalEntity	subscapular artery	The subscapular artery, the largest branch of the axillary artery, arises at the lower border of the Subscapularis, which it follows to the inferior angle of the scapula, where it anastomoses with the lateral thoracic and intercostal arteries and with the descending branch of the transverse cervical, and ends in the neighboring muscles. About 4 cm. from its origin it gives off two branches, first the scapular circumflex artery and then the thoracodorsal artery. [WP,unvetted].	UMLS:C0226422|EMAPA:37116|NCIT:C33650|FMA:22677|MA:0002050	hp.json	arteria subscapularis	http://purl.obolibrary.org/obo/UBERON_0001397		uberon_slim|human_reference_atlas
UBERON:0001380	biolink:AnatomicalEntity	vastus medialis	The vastus medialis, often called the 'teardrop' muscle, is a medially located muscle of the quadriceps. [WP,unvetted].	EMAPA:36245|MA:0002403|NCIT:C117736|galen:VastusMedialis|BTO:0004913|FMA:22432	hp.json	vastus medialis muscle|vastus internus|medialis	http://purl.obolibrary.org/obo/UBERON_0001380		uberon_slim
UBERON:0001383	biolink:AnatomicalEntity	muscle of leg	A muscle that is part of the region of the hindlimb between the pelvis and ankle.	EMAPA:19318|EHDAA:8291|MA:0000672|BTO:0000722|EMAPA:19144|RETIRED_EHDAA2:0000974	hp.json	leg muscle|muscle of hindlimb zeugopod or stylopod|muscle of thigh or crus|leg skeletal muscle tissue|skeletal muscle of leg|muscle of upper or lower hindlimb segment|muscle of upper/lower leg|leg skeletal muscle|leg muscle organ|muscle organ of leg	http://purl.obolibrary.org/obo/UBERON_0001383		uberon_slim|pheno_slim
UBERON:0001389	biolink:AnatomicalEntity	soleus muscle	A deep muscle of the triceps surae group, in the superficial posterior compartment of the leg.	FMA:22542|EMAPA:35786|BTO:0001265|UMLS:C0242694|galen:Soleus|EFO:0001946|MA:0002424|NCIT:C53075	hp.json	soleus	http://purl.obolibrary.org/obo/UBERON_0001389		uberon_slim|pheno_slim|efo_slim
UBERON:0001388	biolink:AnatomicalEntity	gastrocnemius	The most superficial muscle of the triceps surae group, in the posterior portion of the lower hindleg.	FMA:22541|MA:0002306|EMAPA:35375|EHDAA2:0000701|NCIT:C32666|BTO:0000506|UMLS:C0242691|EHDAA:8293|galen:Gastrocnemius|VHOG:0001193|EFO:0001413	hp.json	m. gastrocnemius|musculus gastrocnemius|m.gastrocnemius|gastrocnemius muscle	http://purl.obolibrary.org/obo/UBERON_0001388		uberon_slim|pheno_slim|efo_slim
UBERON:0001385	biolink:AnatomicalEntity	tibialis anterior	A muscle that originates in the upper two-thirds of the lateral surface of the tibia and inserts into the medial cuneiform and first metatarsal bones of the foot. Its acts to invert the foot. It is situated on the lateral side of the tibia; it is thick and fleshy above, tendinous below. This muscle overlaps the anterior tibial vessels and deep peroneal nerve in the upper part of the leg. [WP,unvetted]. The M. tibialis cranialis is a muscle that flexes the tarsometatarsus. It originates on the craniodistal aspect of the femur and proximal tibiotarsus and inserts on the cranial surface of the tarsometarsus[EvoWiki].	EFO:0001385|UMLS:C1710423|BTO:0001382|NCIT:C53079|galen:TibialisAnterior|MA:0002395|EMAPA:35866|FMA:22532	hp.json	ibialis anticus|tibialis cranialis|tibialis anterior muscle|tibilais cranialis|musculus tibialis anterior|anterior tibialis	http://purl.obolibrary.org/obo/UBERON_0001385		uberon_slim|pheno_slim|efo_slim
UBERON:0001384	biolink:AnatomicalEntity	primary motor cortex	The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html.	NCIT:C97339|EFO:0002472|MESH:D009044|BM:Tel-Cx-M1|MA:0000907|BAMS:MOp|EMAPA:35704|BAMS:M1|MBA:985|DHBA:10162|BAMS:MO|BTO:0004348|UMLS:C0026607|NLX:143555|FMA:224854	hp.json	Rolando's area|excitable area|somatic motor areas|motor area|prefrontal gyrus|gyrus precentralis|motor cortex|primary motor area|somatomotor areas	http://purl.obolibrary.org/obo/UBERON_0001384		uberon_slim|pheno_slim|efo_slim|human_reference_atlas
GO:1901509	biolink:BiologicalProcess	regulation of endothelial tube morphogenesis	Any process that modulates the frequency, rate or extent of endothelial tube morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_1901509		
GO:0060411	biolink:BiologicalProcess	cardiac septum morphogenesis	The process in which the anatomical structure of a cardiac septum is generated and organized. A cardiac septum is a partition that separates parts of the heart.		hp.json	heart septum morphogenesis	http://purl.obolibrary.org/obo/GO_0060411		
GO:0060412	biolink:BiologicalProcess	ventricular septum morphogenesis	The developmental process in which a ventricular septum is generated and organized. A ventricular septum is an anatomical structure that separates the lower chambers (ventricles) of the heart from one another.		hp.json	interventricular septum morphogenesis	http://purl.obolibrary.org/obo/GO_0060412		
PR:000009127	biolink:Protein	integrin alpha-IIb	An integrin alpha lacking A domain that is a translation product of the human ITGA2B gene or a 1:1 ortholog thereof.	IUPHARobj:2441	hp.json	platelet membrane glycoprotein IIb|ITGA2B|GPalpha IIb|ITGAB|GP2B|CD41|GPIIb	http://purl.obolibrary.org/obo/PR_000009127		
GO:0060413	biolink:BiologicalProcess	atrial septum morphogenesis	The developmental process in which atrial septum is generated and organized. The atrial septum separates the upper chambers (the atria) of the heart from one another.		hp.json	interatrial septum morphogenesis	http://purl.obolibrary.org/obo/GO_0060413		
GO:0060414	biolink:BiologicalProcess	aorta smooth muscle tissue morphogenesis	The process in which the structure of the smooth muscle tissue surrounding the aorta is generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0060414		
GO:0060415	biolink:BiologicalProcess	muscle tissue morphogenesis	The process in which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function.		hp.json		http://purl.obolibrary.org/obo/GO_0060415		
OIO:hasOBOFormatVersion	biolink:NamedThing	has_obo_format_version			hp.json		http://www.geneontology.org/formats/oboInOwl#hasOBOFormatVersion		
UBERON:0001378	biolink:AnatomicalEntity	rectus femoris	The Rectus femoris muscle is one of the four quadriceps muscles of the human body. (The others are the vastus medialis, the vastus intermedius, and the vastus lateralis. All four combine to form the quadriceps tendon, which inserts into the patella and continues as the patellar ligament. ) The Rectus femoris is situated in the middle of the front of the thigh; it is fusiform in shape, and its superficial fibers are arranged in a bipenniform manner, the deep fibers running straight down to the deep aponeurosis. [WP,unvetted].	BTO:0001564|FMA:22430|EMAPA:36266|MA:0002365|UMLS:C0584894|NCIT:C53175	hp.json	musculus rectos femoris	http://purl.obolibrary.org/obo/UBERON_0001378		uberon_slim
UBERON:0001377	biolink:AnatomicalEntity	quadriceps femoris	One of the muscles belong to the group consisting of the rectus femoris and the three heads of the vastus (lateralis, medialis, intermedius).	EHDAA2:0001583|EHDAA:8299|EFO:0001938|UMLS:C0224440|VHOG:0000828|EMAPA:19146|FMA:22428|OpenCyc:Mx4rvVjd-JwpEbGdrcN5Y29ycA|galen:QuadricepsFemoris|BTO:0001149|MA:0002363|NCIT:C33441	hp.json	musculus quadriceps femoris|quadricep muscle|quadriceps muscle of the thigh|quadriceps muscle of thigh|quadriceps femoris muscle|quadriceps muscle|quadriceps|musculus quadriceps femoris	http://purl.obolibrary.org/obo/UBERON_0001377		efo_slim|uberon_slim|pheno_slim
UBERON:0001379	biolink:AnatomicalEntity	vastus lateralis	The Vastus lateralis (Vastus externus) is the largest part of the Quadriceps femoris. It arises by a broad aponeurosis, which is attached to the upper part of the intertrochanteric line, to the anterior and inferior borders of the greater trochanter, to the lateral lip of the gluteal tuberosity, and to the upper half of the lateral lip of the linea aspera; this aponeurosis covers the upper three-fourths of the muscle, and from its deep surface many fibers take origin. A few additional fibers arise from the tendon of the Glutæus maximus, and from the lateral intermuscular septum between the Vastus lateralis and short head of the Biceps femoris. The fibers form a large fleshy mass, which is attached to a strong aponeurosis, placed on the deep surface of the lower part of the muscle: this aponeurosis becomes contracted and thickened into a flat tendon inserted into the lateral border of the patella, blending with the Quadriceps femoris tendon, and giving an expansion to the capsule of the knee-joint. [WP,unvetted].	NCIT:C53073|BTO:0001563|FMA:22431|EFO:0001937|EMAPA:36244|MA:0002402|galen:VastusLateralis|UMLS:C0224444	hp.json	lateralis|vastus lateralis muscle|vastus externus	http://purl.obolibrary.org/obo/UBERON_0001379		efo_slim|uberon_slim
GO:0060419	biolink:BiologicalProcess	heart growth	The increase in size or mass of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0060419		
UBERON:0001359	biolink:AnatomicalEntity	cerebrospinal fluid	A clear, colorless, bodily fluid, that occupies the subarachnoid space and the ventricular system around and inside the brain and spinal cord.	MAT:0000499|MESH:D002555|BTO:0000237|EV:0100311|NCIT:C12692|ZFA:0001626|EHDAA2:0004441|BIRNLEX:1798|TAO:0002184|VHOG:0001278|UMLS:C0007806|ENVO:02000029|MA:0002503|GAID:1181|EFO:0000329|FMA:20935|CALOHA:TS-0130|UMLS:C0007806	hp.json	liquor cerebrospinalis|spinal fluid|CSF|cerebral spinal fluid	http://purl.obolibrary.org/obo/UBERON_0001359		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0001361	biolink:AnatomicalEntity	femoral vein	In the human body, the femoral vein is a blood vessel that accompanies the femoral artery in the femoral sheath. It begins at the adductor canal (also known as Hunter's canal) and is a continuation of the popliteal vein. It ends at the inferior margin of the inguinal ligament, where it becomes the external iliac vein. [WP,unvetted].	NCIT:C12716|galen:FemoralVein|EMAPA:17876|GAID:533|MA:0002118|FMA:21185|AAO:0010237|UMLS:C0015809|OpenCyc:Mx4rwFXTLJwpEbGdrcN5Y29ycA|MESH:D005268	hp.json	vena femoralis	http://purl.obolibrary.org/obo/UBERON_0001361		human_reference_atlas|uberon_slim
CHEBI:36735	biolink:ChemicalSubstance	biladienes	Compounds based on a biladiene skeleton.		hp.json		http://purl.obolibrary.org/obo/CHEBI_36735		3_STAR
GO:0060404	biolink:BiologicalProcess	axonemal microtubule depolymerization	The removal of tubulin heterodimers from one or both ends of an axonemal microtubule. An axonemal microtubule is a microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules.		hp.json		http://purl.obolibrary.org/obo/GO_0060404		
GO:0060405	biolink:BiologicalProcess	regulation of penile erection	Any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.		hp.json		http://purl.obolibrary.org/obo/GO_0060405		
CHEBI:48706	biolink:ChemicalSubstance	antagonist	Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances.		hp.json	antagoniste|antagonists|antagonista|antagonist	http://purl.obolibrary.org/obo/CHEBI_48706		3_STAR
CHEBI:48705	biolink:ChemicalSubstance	agonist	Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own.		hp.json	agonista|agonist|agoniste|agonists	http://purl.obolibrary.org/obo/CHEBI_48705		3_STAR
UBERON:0001366	biolink:AnatomicalEntity	parietal peritoneum	The outer layer of peritoneum that is attached to the abdominal and pelvic walls.	ZFA:0005131|AAO:0010816|SCTID:362700006|TAO:0005131|FMA:21451|Wikipedia:Parietal_peritoneum|VHOG:0001527|EMAPA:16591	hp.json	parietal serous membrane of peritoneum|peritoneal cavity lining	http://purl.obolibrary.org/obo/UBERON_0001366		uberon_slim|vertebrate_core
GO:0060406	biolink:BiologicalProcess	positive regulation of penile erection	Any process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.		hp.json		http://purl.obolibrary.org/obo/GO_0060406		
GO:0060407	biolink:BiologicalProcess	negative regulation of penile erection	Any process that stops, prevents, or reduces the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.		hp.json		http://purl.obolibrary.org/obo/GO_0060407		
UBERON:0001365	biolink:AnatomicalEntity	sacro-iliac joint	The joint in the bony pelvis between the sacrum and the ilium of the pelvis, which are joined by strong ligaments.	MA:0001506|UMLS:C0036036|NCIT:C33507|FMA:21440|GAID:268|MESH:D012446|EMAPA:19300	hp.json	articulatio sacro-iliaca|sacroiliac joint	http://purl.obolibrary.org/obo/UBERON_0001365		uberon_slim|pheno_slim
GO:0060431	biolink:BiologicalProcess	primary lung bud formation	The morphogenetic process in which the foregut region specified to become the lung forms the initial left and right buds.		hp.json	lung formation	http://purl.obolibrary.org/obo/GO_0060431		
CHEBI:36700	biolink:ChemicalSubstance	phosphocholines			hp.json		http://purl.obolibrary.org/obo/CHEBI_36700		
GO:0060437	biolink:BiologicalProcess	lung growth	The increase in size or mass of a lung. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.		hp.json		http://purl.obolibrary.org/obo/GO_0060437		
GO:0060438	biolink:BiologicalProcess	trachea development	The process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.		hp.json		http://purl.obolibrary.org/obo/GO_0060438		
GO:0060439	biolink:BiologicalProcess	trachea morphogenesis	The process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches.		hp.json		http://purl.obolibrary.org/obo/GO_0060439		
SO:0000110	biolink:SequenceFeature	sequence_feature	An extent of biological sequence.		hp.json	sequence feature|located_sequence_feature|located sequence feature	http://purl.obolibrary.org/obo/SO_0000110		
GO:1901534	biolink:BiologicalProcess	positive regulation of hematopoietic progenitor cell differentiation	Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation.		hp.json	activation of hemopoietic progenitor cell differentiation|up regulation of hematopoietic progenitor cell differentiation|up-regulation of haemopoietic progenitor cell differentiation|positive regulation of hemopoietic progenitor cell differentiation|activation of haematopoietic progenitor cell differentiation|upregulation of haematopoietic progenitor cell differentiation|upregulation of hemopoietic progenitor cell differentiation|upregulation of hematopoietic progenitor cell differentiation|activation of haemopoietic progenitor cell differentiation|upregulation of haemopoietic progenitor cell differentiation|activation of hematopoietic progenitor cell differentiation|positive regulation of haematopoietic progenitor cell differentiation|up regulation of haematopoietic progenitor cell differentiation|up-regulation of hemopoietic progenitor cell differentiation|positive regulation of haemopoietic progenitor cell differentiation|up-regulation of haematopoietic progenitor cell differentiation|up-regulation of hematopoietic progenitor cell differentiation|up regulation of haemopoietic progenitor cell differentiation|up regulation of hemopoietic progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_1901534		
GO:1901532	biolink:BiologicalProcess	regulation of hematopoietic progenitor cell differentiation	Any process that modulates the frequency, rate or extent of hematopoietic progenitor cell differentiation.		hp.json	regulation of haemopoietic progenitor cell differentiation|regulation of hemopoietic progenitor cell differentiation|regulation of haematopoietic progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_1901532		
GO:1901533	biolink:BiologicalProcess	negative regulation of hematopoietic progenitor cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic progenitor cell differentiation.		hp.json	downregulation of haemopoietic progenitor cell differentiation|down regulation of haematopoietic progenitor cell differentiation|inhibition of hematopoietic progenitor cell differentiation|down-regulation of haematopoietic progenitor cell differentiation|down regulation of haemopoietic progenitor cell differentiation|negative regulation of haematopoietic progenitor cell differentiation|down-regulation of hemopoietic progenitor cell differentiation|negative regulation of hemopoietic progenitor cell differentiation|down-regulation of hematopoietic progenitor cell differentiation|down regulation of hemopoietic progenitor cell differentiation|negative regulation of haemopoietic progenitor cell differentiation|down-regulation of haemopoietic progenitor cell differentiation|inhibition of haematopoietic progenitor cell differentiation|down regulation of hematopoietic progenitor cell differentiation|inhibition of hemopoietic progenitor cell differentiation|downregulation of hemopoietic progenitor cell differentiation|inhibition of haemopoietic progenitor cell differentiation|downregulation of hematopoietic progenitor cell differentiation|downregulation of haematopoietic progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_1901533		
GO:0060420	biolink:BiologicalProcess	regulation of heart growth	Any process that modulates the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0060420		
GO:0060421	biolink:BiologicalProcess	positive regulation of heart growth	Any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0060421		
CHEBI:36711	biolink:ChemicalSubstance	phosphoethanolamine			hp.json	phosphoethanolamines	http://purl.obolibrary.org/obo/CHEBI_36711		3_STAR
GO:0060425	biolink:BiologicalProcess	lung morphogenesis	The process in which the anatomical structures of the lung are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060425		
GO:0060426	biolink:BiologicalProcess	lung vasculature development	The biological process whose specific outcome is the progression of a lung vasculature from an initial condition to its mature state. This process begins with the formation of the lung vasculature and ends with the mature structure. The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs.		hp.json	pulmonary vasculature development	http://purl.obolibrary.org/obo/GO_0060426		
GO:0060427	biolink:BiologicalProcess	lung connective tissue development	The biological process whose specific outcome is the progression of lung connective tissue from an initial condition to its mature state. This process begins with the formation of lung connective tissue and ends with the mature structure. The lung connective tissue is a material made up of fibers forming a framework and support structure for the lungs.		hp.json	pulmonary connective tissue development	http://purl.obolibrary.org/obo/GO_0060427		
GO:0060428	biolink:BiologicalProcess	lung epithelium development	The biological process whose specific outcome is the progression of the lung epithelium from an initial condition to its mature state. This process begins with the formation of lung epithelium and ends with the mature structure. The lung epithelium is the specialized epithelium that lines the inside of the lung.		hp.json	pulmonary epithelium development	http://purl.obolibrary.org/obo/GO_0060428		
GO:0060429	biolink:BiologicalProcess	epithelium development	The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.		hp.json		http://purl.obolibrary.org/obo/GO_0060429		goslim_drosophila
OIO:hasBroadSynonym	biolink:NamedThing	has_broad_synonym			hp.json		http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym		
NCBITaxon:33154	biolink:OrganismalEntity	Opisthokonta		GC_ID:1	hp.json	opisthokonts|Fungi/Metazoa group	http://purl.obolibrary.org/obo/NCBITaxon_33154		
GO:0060450	biolink:BiologicalProcess	positive regulation of hindgut contraction	Any process that increases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.		hp.json		http://purl.obolibrary.org/obo/GO_0060450		
GO:0060451	biolink:BiologicalProcess	negative regulation of hindgut contraction	Any process that decreases the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.		hp.json		http://purl.obolibrary.org/obo/GO_0060451		
GO:0060452	biolink:BiologicalProcess	positive regulation of cardiac muscle contraction	Any process that increases the frequency, rate or extent of cardiac muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_0060452		
GO:0060453	biolink:BiologicalProcess	regulation of gastric acid secretion	Any process that modulates the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.		hp.json		http://purl.obolibrary.org/obo/GO_0060453		
GO:0060454	biolink:BiologicalProcess	positive regulation of gastric acid secretion	Any process that increases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.		hp.json		http://purl.obolibrary.org/obo/GO_0060454		
GO:0060455	biolink:BiologicalProcess	negative regulation of gastric acid secretion	Any process that decreases the rate frequency or extent of gastric secretion. Gastric secretion is the regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.		hp.json		http://purl.obolibrary.org/obo/GO_0060455		
GO:0060456	biolink:BiologicalProcess	positive regulation of digestive system process	Any process that increases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.		hp.json		http://purl.obolibrary.org/obo/GO_0060456		
GO:0060457	biolink:BiologicalProcess	negative regulation of digestive system process	Any process that decreases the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.		hp.json		http://purl.obolibrary.org/obo/GO_0060457		
GO:0060458	biolink:BiologicalProcess	right lung development	The biological process whose specific outcome is the progression of a right lung from an initial condition to its mature state. This process begins with the formation of the right lung and ends with the mature structure. The right lung is the lung which is on the right side of the anterior posterior axis looking from a dorsal to ventral aspect.		hp.json	right pulmonary development	http://purl.obolibrary.org/obo/GO_0060458		
GO:0060459	biolink:BiologicalProcess	left lung development	The biological process whose specific outcome is the progression of a left lung from an initial condition to its mature state. This process begins with the formation of the left lung and ends with the mature structure. The left lung is the lung which is on the left side of the anterior posterior axis looking from a dorsal to ventral aspect.		hp.json	left pulmonary development	http://purl.obolibrary.org/obo/GO_0060459		
CHEBI:24712	biolink:ChemicalSubstance	hydroxymethyl group			hp.json	serine side-chain|-CH2-OH|hydroxymethyl	http://purl.obolibrary.org/obo/CHEBI_24712		3_STAR
GO:1901552	biolink:BiologicalProcess	positive regulation of endothelial cell development	Any process that activates or increases the frequency, rate or extent of endothelial cell development.		hp.json	activation of endothelial cell development|upregulation of endothelial cell development|up regulation of endothelial cell development|up-regulation of endothelial cell development	http://purl.obolibrary.org/obo/GO_1901552		
GO:1901550	biolink:BiologicalProcess	regulation of endothelial cell development	Any process that modulates the frequency, rate or extent of endothelial cell development.		hp.json		http://purl.obolibrary.org/obo/GO_1901550		
GO:1901551	biolink:BiologicalProcess	negative regulation of endothelial cell development	Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development.		hp.json	down regulation of endothelial cell development|inhibition of endothelial cell development|down-regulation of endothelial cell development|downregulation of endothelial cell development	http://purl.obolibrary.org/obo/GO_1901551		
GO:0060440	biolink:BiologicalProcess	trachea formation	The process pertaining to the initial formation of a trachea from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the trachea is recognizable. The trachea is the portion of the airway that attaches to the bronchi as it branches.		hp.json		http://purl.obolibrary.org/obo/GO_0060440		
GO:0060441	biolink:BiologicalProcess	epithelial tube branching involved in lung morphogenesis	The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.		hp.json	lung branching morphogenesis	http://purl.obolibrary.org/obo/GO_0060441		
UBERON:0001429	biolink:AnatomicalEntity	pisiform	A laterally positioned sesamoid bone found in close proximity with and occasionally fused to the ulnare.	MA:0001339|galen:Pisiform|NCIT:C12855|FMA:23718|EMAPA:36165|OpenCyc:Mx4rvtByTZwpEbGdrcN5Y29ycA|UMLS:C0223729	hp.json	pisiform bone|os pisiforme|accessory carpal bone	http://purl.obolibrary.org/obo/UBERON_0001429		uberon_slim
HP:0030170	biolink:PhenotypicFeature	Cystic artery pseudoaneurysm	Presence of a pseudoaneurysm in the artery that supplies the gallbladder and cystic duct with blood. A pseudoaneurysm, also known as a false aneurysm, forms when blood leaks through a breach of the arterial wall but is contained by the adventitia or surrounding perivascular soft tissue.	UMLS:C4022601	hp.json		http://purl.obolibrary.org/obo/HP_0030170		
HP:0030171	biolink:PhenotypicFeature	Perirenal hematoma	A collection of clotted blood surrounding the kidney.	UMLS:C0473124|SNOMEDCT_US:197824007	hp.json		http://purl.obolibrary.org/obo/HP_0030171		
UBERON:0001425	biolink:AnatomicalEntity	pectoral lymphatic vessel		ZFA:0005107|TAO:0005107|FMA:234865	hp.json	PL	http://purl.obolibrary.org/obo/UBERON_0001425		vertebrate_core
UBERON:0001428	biolink:AnatomicalEntity	intermedium	Endochondral carpal bone articulating with the ulnare and the radiale.	MA:0002556|MESH:D012667|galen:Lunate|EMAPA:37659|NCIT:C12786|UMLS:C0036624|VSAO:0005040|FMA:23712|GAID:181	hp.json	semilunate|os lunatum|semilunar|os carpi intermedium|lunate|intermediate carpal bone|lunar|semilunar bone|intermedium|os lunatum|lunate bone	http://purl.obolibrary.org/obo/UBERON_0001428		uberon_slim|pheno_slim
UBERON:0001427	biolink:AnatomicalEntity	radiale	Endochondral proximal carpal bone articulating with the radius.	GAID:180|EMAPA:37660|AAO:0000790|UMLS:C0223724|galen:Scaphoid|FMA:23709|MA:0002555|NCIT:C12854|OpenCyc:Mx4rwAwWe5wpEbGdrcN5Y29ycA|MESH:D021361	hp.json	os scaphoideum|scaphoid bone|scaphoid|scaphoideum|navicular bone of manus|radial carpal bone|navicular of manus|os naviculare manus|navicular of hand|os carpi radiale|navicular bone of hand	http://purl.obolibrary.org/obo/UBERON_0001427		uberon_slim|pheno_slim
UBERON:0013411	biolink:AnatomicalEntity	cranial cavity	Anatomical cavity that is the lumen of the skull and contains the brain.	Wikipedia:Cranial_cavity|FMA:9644|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2806|SCTID:264452006|UMLS:C0230041|EMAPA:37497|NCIT:C77638|MA:0003061	hp.json	cavitas cranii|intracranial space|intracranial space|intracranial cavity|intracranial cavity	http://purl.obolibrary.org/obo/UBERON_0013411		
HP:0030176	biolink:PhenotypicFeature	Asymmetric peripheral demyelination	Loss of myelin from peripheral nerves in a pattern that differs between right and left.	UMLS:C4022598	hp.json		http://purl.obolibrary.org/obo/HP_0030176		
HP:0030177	biolink:PhenotypicFeature	Abnormality of peripheral nervous system electrophysiology	An abnormality of the function of the electrical signals with which peripheral nerve cells communicate with each other or with muscles.	UMLS:C0853150	hp.json	Abnormal nerve conduction study	http://purl.obolibrary.org/obo/HP_0030177		
PATO:0001697	biolink:NamedThing	decreased photosensitivity	A photosensitivity which is relatively low.		hp.json	low photosensitivity	http://purl.obolibrary.org/obo/PATO_0001697		disposition_slim|relational_slim|value_slim
HP:0030178	biolink:PhenotypicFeature	Abnormality of central nervous system electrophysiology		UMLS:C4022597	hp.json	Abnormality of CNS electrophysiology	http://purl.obolibrary.org/obo/HP_0030178		
HP:0030179	biolink:PhenotypicFeature	Abnormal peripheral action potential amplitude	An anomaly in the magnitude of the action potential along a peripheral nerve, that is, of the rapid rise and fall of the electrical membrane potential of the nerve.	UMLS:C4022596	hp.json		http://purl.obolibrary.org/obo/HP_0030179		
PATO:0001698	biolink:NamedThing	increased photosensitivity	A photosensitivity which is relatively high.		hp.json	high photosensitivity	http://purl.obolibrary.org/obo/PATO_0001698		disposition_slim|relational_slim|value_slim
HP:0030172	biolink:PhenotypicFeature	Peripheral amyelination	Congenital absence of the myelin sheath on a nerve.	UMLS:C4022600	hp.json		http://purl.obolibrary.org/obo/HP_0030172		
HP:0030173	biolink:PhenotypicFeature	Peripheral hypermyelination	Increased amount of peripheral myelination.	UMLS:C4021049	hp.json	Increased peripheral myelination	http://purl.obolibrary.org/obo/HP_0030173		
HP:0030174	biolink:PhenotypicFeature	Increased peripheral myelin thickness	Elevated thickness of the myelin sheath of peripheral nerves, in a regular and concentric fashion.	UMLS:C4022599	hp.json		http://purl.obolibrary.org/obo/HP_0030174		
HP:0030175	biolink:PhenotypicFeature	Myelin tomacula	The presence of multiple sausage-shaped swellings of the myelin sheath (The Latin tomaculum means sausage).	UMLS:C4020904	hp.json	Tomacula	http://purl.obolibrary.org/obo/HP_0030175		
PATO:0001690	biolink:NamedThing	contractile	A contractility quality inhering in a bearer by virtue of the bearer's ability of contracting or being contracted.		hp.json		http://purl.obolibrary.org/obo/PATO_0001690		disposition_slim|value_slim
PATO:0001693	biolink:NamedThing	increased viscosity	A viscosity which relatively high.		hp.json	high viscosity	http://purl.obolibrary.org/obo/PATO_0001693		disposition_slim|value_slim
PATO:0001694	biolink:NamedThing	decreased viscosity	A viscosity which relatively low.		hp.json	low viscosity	http://purl.obolibrary.org/obo/PATO_0001694		disposition_slim|value_slim
UBERON:0001433	biolink:AnatomicalEntity	distal carpal bone 4		OpenCyc:Mx4rwFTmuJwpEbGdrcN5Y29ycA|VSAO:0005046|galen:Hamate|MA:0001343|EMAPA:36172|NCIT:C12860|AAO:0000850|UMLS:C0560737|FMA:23730	hp.json	os hamatum|os hamatum|carpal 4|unciform bone|distal carpal 4|hand distal carpal bone 4|uncinate|hamate|hamate bone|unciform	http://purl.obolibrary.org/obo/UBERON_0001433		uberon_slim|pheno_slim
UBERON:0001432	biolink:AnatomicalEntity	distal carpal bone 3		NCIT:C12856|VSAO:0005045|FMA:23727|MA:0001342|OpenCyc:Mx4rvZFPrZwpEbGdrcN5Y29ycA|galen:Capitate|UMLS:C0223733|AAO:0000849|EMAPA:36169	hp.json	os magnum (carpus)|distal carpal 3|capitate|os capitatum|os magnum|capitate bone|hand distal carpal bone 3|carpal 3|magnum	http://purl.obolibrary.org/obo/UBERON_0001432		pheno_slim|uberon_slim
UBERON:0001435	biolink:AnatomicalEntity	carpal bone	A bone that is part of the carpal skeleton. Examples: scaphoid, lunate, capitate[cjm].	EMAPA:25056|GAID:179|MESH:D002348|NCIT:C12688|galen:CarpalBone|MA:0000296|FMA:23889|UMLS:C0007285	hp.json	carpal skeleton bone|carpus bone|bone of carpus|carpal	http://purl.obolibrary.org/obo/UBERON_0001435		uberon_slim|pheno_slim
UBERON:0001434	biolink:AnatomicalEntity	skeletal system	Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system.	EMAPA:35773|MA:0000018|VHOG:0001254|FMA:23881|ZFA:0000434|CALOHA:TS-1320|NCIT:C12788|TAO:0000434|AAO:0000566|OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA|EHDAA2:0003168|VSAO:0000027|UMLS:C0037253|BTO:0001486|XAO:0003060|EFO:0000806	hp.json	skeleton system|set of all bones and joints|Skelettsystem	http://purl.obolibrary.org/obo/UBERON_0001434		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0001431	biolink:AnatomicalEntity	distal carpal bone 2		VSAO:0005044|EMAPA:36174|UMLS:C0223741|MA:0001341|galen:Trapezoid|FMA:23724|OpenCyc:Mx4rvVvsjpwpEbGdrcN5Y29ycA|OpenCyc:Mx4rvxNWBJwpEbGdrcN5Y29ycA|NCIT:C12859|AAO:0000848	hp.json	distal carpal 2|trapezoid|os trapezoideum|lesser multiangular|trapezoid bone|lesser multangular bone|carpal 2|hand distal carpal bone 2|manus distal carpal bone 2|lesser multangular	http://purl.obolibrary.org/obo/UBERON_0001431		pheno_slim|uberon_slim
UBERON:0001430	biolink:AnatomicalEntity	distal carpal bone 1		AAO:0010634|VSAO:0005043|UMLS:C0223736|EMAPA:36173|MA:0001340|OpenCyc:Mx4rv3CbrJwpEbGdrcN5Y29ycA|FMA:23721|NCIT:C12857|galen:Trapezium	hp.json	trapezial bone|distal carpal 1|os trapezium|carpal 1|greater multangular bone|greater multangular|trapezium|hand distal carpal bone 1|greater multiangular|trapezium bone|manus distal carpal bone 1	http://purl.obolibrary.org/obo/UBERON_0001430		pheno_slim|uberon_slim
UBERON:0001419	biolink:AnatomicalEntity	skin of limb	A zone of skin that is part of a limb [Automatically generated definition].	UMLS:C1282135|FMA:23100|EMAPA:32726|MA:0000694|NCIT:C53276	hp.json	limb zone of skin|zone of skin of limb|limb skin	http://purl.obolibrary.org/obo/UBERON_0001419		pheno_slim
UBERON:0001418	biolink:AnatomicalEntity	skin of thorax	A zone of skin that is part of a thorax [Automatically generated definition].	FMA:23029|FMA:23028|MA:0000564|SCTID:281723000|EMAPA:37765	hp.json	upper body skin|thorax zone of skin|thorax skin|thoracic skin|zone of skin of thorax	http://purl.obolibrary.org/obo/UBERON_0001418		
HP:0030180	biolink:PhenotypicFeature	Oppenheim reflex	Dorsiflexion of the big toe, sometimes accompanied by fanning of the other toes, elicited by stroking along the medial side of the tibia (the normal response would be no movement of the big toe).	UMLS:C1532837|SNOMEDCT_US:414949005	hp.json	Oppenheim sign	http://purl.obolibrary.org/obo/HP_0030180		
HP:0030181	biolink:PhenotypicFeature	Gordon reflex	Dorsal extension of the big toe, sometimes accompanied by fanning of the other toes, elicited by compressing the calf muscles (a normal response is no movement of the big toe).	UMLS:C4021048	hp.json	Gordon sign	http://purl.obolibrary.org/obo/HP_0030181		
HP:0030182	biolink:PhenotypicFeature	Tetraplegia/tetraparesis	Loss of strength in all four limbs. Tetraplegia refers to a complete loss of strength, whereas Tetraparesis refers to an incomplete loss of strength.	UMLS:C4022595	hp.json		http://purl.obolibrary.org/obo/HP_0030182		
UBERON:0001415	biolink:AnatomicalEntity	skin of pelvis	A zone of skin that is part of a pelvis [Automatically generated definition].	FMA:22984|MA:0000546|EMAPA:37282|SCTID:181517009	hp.json	zone of skin of pelvis|pelvis skin|pelvic skin|pelvis zone of skin	http://purl.obolibrary.org/obo/UBERON_0001415		
UBERON:0001417	biolink:AnatomicalEntity	skin of neck	A zone of skin that is part of a neck [Automatically generated definition].	UMLS:C0205030|MA:0000590|EMAPA:37277|NCIT:C52756|FMA:23022|FMA:23021|SCTID:361705004	hp.json	neck zone of skin|neck skin|zone of skin of neck (volume)|neck (volume) zone of skin|zone of skin of neck	http://purl.obolibrary.org/obo/UBERON_0001417		
UBERON:0001416	biolink:AnatomicalEntity	skin of abdomen	A zone of skin that is part of an abdomen [Automatically generated definition].	NCIT:C52758|MA:0000523|FMA:23000|SCTID:361707007|FMA:22988|EFO:0000214|UMLS:C0222166	hp.json	skin of abdomen proper|abdomen skin|zone of skin of abdomen|abdominal skin|abdomen zone of skin	http://purl.obolibrary.org/obo/UBERON_0001416		efo_slim|pheno_slim
HP:0030187	biolink:PhenotypicFeature	Titubation	Nodding movement of the head or body.	UMLS:C0231690|SNOMEDCT_US:78691002	hp.json		http://purl.obolibrary.org/obo/HP_0030187		
HP:0030188	biolink:PhenotypicFeature	Tremor by anatomical site	Tremor classified by the affected body part.	UMLS:C4022593	hp.json	Tremor of a body part	http://purl.obolibrary.org/obo/HP_0030188		
HP:0030183	biolink:PhenotypicFeature	Impaired visually enhanced vestibulo-ocular reflex	The vestibulo-ocular reflex is responsible for the stabilization of the retinal image during movement. The visual vestibular ocular reflex (VVOR) or visual enhanced VOR, maintains ocular stability during head motion by generating compensatory eye movement opposite to head movement, and is a major component of visual vestibular interaction. This feature is an impairment of this reflex, manifested as the combined impairment of the three compensatory eye movement reflexes, namely the vestibulo-ocular reflex (VOR), smooth pursuit (SP) and optokinetic reflex (OKR).	UMLS:C4021047	hp.json	Visually enhanced vestibulo-ocular reflex impairment|VVOR impairment	http://purl.obolibrary.org/obo/HP_0030183		
HP:0030185	biolink:PhenotypicFeature	Isometric tremor	An isometric tremor occurs with muscle contraction against a rigid stationary object (e.g., when making a fist).	UMLS:C4022594|UMLS:C4280303	hp.json	Dystonia tremor	http://purl.obolibrary.org/obo/HP_0030185		
HP:0030186	biolink:PhenotypicFeature	Kinetic tremor	Tremor that occurs during any voluntary movement. It may include visually or non-visually guided movements. Tremor during target directed movement is called intention tremor.	SNOMEDCT_US:30721006|MSH:D014202|SNOMEDCT_US:609558009|MSH:D020329|UMLS:C0270736|UMLS:C0234376	hp.json	Essential tremor	http://purl.obolibrary.org/obo/HP_0030186		
CHEBI:58001	biolink:ChemicalSubstance	primary aliphatic ammonium ion	The conjugate acid of a primary aliphatic amine.		hp.json	primary aliphatic ammonium cation|an aliphatic amine|primary aliphatic ammonium ions|primary aliphatic ammonium cations	http://purl.obolibrary.org/obo/CHEBI_58001		3_STAR
UBERON:0001422	biolink:AnatomicalEntity	facial lymphatic vessel	A lymphatic vessel that is part of a face [Automatically generated definition].	ZFA:0005108|TAO:0005108|FMA:233946	hp.json	buccal lymphatic vessel|face lymph vessel|FL|lymphatic vessel of face|face lymphatic vessel|lymph vessel of face	http://purl.obolibrary.org/obo/UBERON_0001422		vertebrate_core
UBERON:0001421	biolink:AnatomicalEntity	pectoral girdle region	An organism subdivision that includes the pectoral girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions.	galen:ShoulderGirdle|EMAPA:37856|VSAO:0000305|FMA:23217	hp.json	cingulum membri superioris|shoulder girdle|upper limb girdle|pectoral region|girdle - pectoral|cingulum membri superioris|pectoral girdle	http://purl.obolibrary.org/obo/UBERON_0001421		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001424	biolink:AnatomicalEntity	ulna	The major postaxial endochondral bone in the anterior zeugopod[Phenoscape].	FMA:23466|MA:0001358|VSAO:0005013|EMAPA:19104|AAO:0000789|GAID:188|MESH:D014457|galen:Ulna|OpenCyc:Mx4rwPtIM5wpEbGdrcN5Y29ycA|NCIT:C12809|UMLS:C0041600	hp.json		http://purl.obolibrary.org/obo/UBERON_0001424		uberon_slim|pheno_slim
UBERON:0001423	biolink:AnatomicalEntity	radius bone	The major preaxial endochondral bone in the anterior zeugopod[Phenoscape].	galen:Radius|FMA:23463|MA:0001357|NCIT:C12777|VSAO:0005012|CALOHA:TS-2199|AAO:0000788|EMAPA:19103|MESH:D011884|GAID:185|OpenCyc:Mx4rwUsDcZwpEbGdrcN5Y29ycA|UMLS:C0034627	hp.json	radius	http://purl.obolibrary.org/obo/UBERON_0001423		uberon_slim|pheno_slim
HP:0005190	biolink:PhenotypicFeature	Proximal finger joint hyperextensibility		UMLS:C4025242	hp.json		http://purl.obolibrary.org/obo/HP_0005190		
HP:0030190	biolink:PhenotypicFeature	Oral motor hypotonia	Reduced muscle tone of oral musculature. In infants, this feature may be associated with difficulties in breast feeding, and may affect the latch, jaw motions, tongue placement, lip seal, suck/swallow/breathe pattern and overall feeding behavior.	UMLS:C4022592	hp.json		http://purl.obolibrary.org/obo/HP_0030190		
HP:0030191	biolink:PhenotypicFeature	Abnormal peripheral nervous system synaptic transmission	An anomaly in the communication from a neuron to a target across a synapse in the peripheral nervous system.	UMLS:C4021046	hp.json	Abnormal PNS synaptic transmission	http://purl.obolibrary.org/obo/HP_0030191		
HP:0005191	biolink:PhenotypicFeature	Congenital knee dislocation		UMLS:C0265669|SNOMEDCT_US:59068006	hp.json	Dislocated knee since birth	http://purl.obolibrary.org/obo/HP_0005191		
HP:0030192	biolink:PhenotypicFeature	Fatigable weakness of bulbar muscles	A type of weakness of the bulbar muscles (muscles of the mouth and throat responsible for speech and swallowing) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C4022591	hp.json		http://purl.obolibrary.org/obo/HP_0030192		
HP:0005193	biolink:PhenotypicFeature	Restricted large joint movement		UMLS:C4025241	hp.json		http://purl.obolibrary.org/obo/HP_0005193		
HP:0030193	biolink:PhenotypicFeature	Fatigable weakness of chewing muscles	A type of weakness of the muscles involved in chewing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C4022590	hp.json		http://purl.obolibrary.org/obo/HP_0030193		
HP:0030198	biolink:PhenotypicFeature	Fatigable weakness of distal limb muscles	A type of weakness of a skeletal muscle of distal part of a limb that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C4022585	hp.json		http://purl.obolibrary.org/obo/HP_0030198		
HP:0030199	biolink:PhenotypicFeature	Fatigable weakness of neck muscles	A type of weakness of a skeletal muscle in the neck that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C4022584	hp.json		http://purl.obolibrary.org/obo/HP_0030199		
HP:0030194	biolink:PhenotypicFeature	Fatigable weakness of speech muscles	A type of weakness of the muscles involved in speech that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C4022589	hp.json		http://purl.obolibrary.org/obo/HP_0030194		
HP:0030195	biolink:PhenotypicFeature	Fatigable weakness of swallowing muscles	A type of weakness of the muscles involved in swallowing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C4022588	hp.json		http://purl.obolibrary.org/obo/HP_0030195		
HP:0030196	biolink:PhenotypicFeature	Fatigable weakness of respiratory muscles	A type of weakness of the muscles involved in breathing (respiration) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C4022587	hp.json		http://purl.obolibrary.org/obo/HP_0030196		
HP:0030197	biolink:PhenotypicFeature	Fatigable weakness of skeletal muscles	A type of weakness of skeletal muscle that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C4022586	hp.json		http://purl.obolibrary.org/obo/HP_0030197		
CHEBI:61697	biolink:ChemicalSubstance	fatty acid derivative	Any organic molecular entity derived from a fatty acid.		hp.json	FA derivative|fatty acid derivatives|FA derivatives	http://purl.obolibrary.org/obo/CHEBI_61697		3_STAR
HP:0005187	biolink:PhenotypicFeature	Progressive joint destruction		UMLS:C4025243	hp.json		http://purl.obolibrary.org/obo/HP_0005187		
HP:0005183	biolink:PhenotypicFeature	Pericardial lymphangiectasia	An abnormal dilatation of lymph vessels in the pericardium.	UMLS:C1856140	hp.json		http://purl.obolibrary.org/obo/HP_0005183		
HP:0005184	biolink:PhenotypicFeature	Prolonged QTc interval	A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations.	UMLS:C1560305	hp.json		http://purl.obolibrary.org/obo/HP_0005184		
HP:0005185	biolink:PhenotypicFeature	Global systolic dysfunction	A reduced ejection fraction and an enlarged left ventricle chamber, the latter by an increased resistance to filling with increased filling pressures. Systolic dysfunction is clinically associated with left ventricular failure in the presence of marked cardiomegaly.	UMLS:C1847397	hp.json		http://purl.obolibrary.org/obo/HP_0005185		
HP:0005186	biolink:PhenotypicFeature	Synovial hypertrophy		MSH:D013585|UMLS:C0410574|SNOMEDCT_US:240206002	hp.json		http://purl.obolibrary.org/obo/HP_0005186		
CHEBI:36699	biolink:ChemicalSubstance	corticosteroid hormone	Any of a class of steroid hormones that are produced in the adrenal cortex.		hp.json	corticosteroid hormones|adrenal cortex hormones	http://purl.obolibrary.org/obo/CHEBI_36699		3_STAR
HP:0005198	biolink:PhenotypicFeature	Stiff interphalangeal joints	Interphalangeal joint stiffness is a perceived sensation of tightness in the interphalangeal joints when attempting to move them after a period of inactivity.	UMLS:C4025237	hp.json	Stiff hinge joints	http://purl.obolibrary.org/obo/HP_0005198		
HP:0005199	biolink:PhenotypicFeature	Aplasia of the abdominal wall musculature	Absence of the abdominal musculature.	UMLS:C3149223	hp.json	Absent abdominal musculature	http://purl.obolibrary.org/obo/HP_0005199		
HP:0005194	biolink:PhenotypicFeature	Flattened metatarsal heads	Abnormally flat shape of the heads of the metatarsal bones.	UMLS:C4025240	hp.json	Flattened head of long bone of foot	http://purl.obolibrary.org/obo/HP_0005194		
HP:0005195	biolink:PhenotypicFeature	Polyarticular arthropathy		UMLS:C4025239	hp.json		http://purl.obolibrary.org/obo/HP_0005195		
HP:0005197	biolink:PhenotypicFeature	Generalized morning stiffness	A sensation of stiffness in the joints that occurs following waking up in the morning.	UMLS:C4025238	hp.json	Generalised morning stiffness	http://purl.obolibrary.org/obo/HP_0005197		
CHEBI:24684	biolink:ChemicalSubstance	hydroxybutyric acid	Any compound comprising a butyric acid core carrying at least one hydroxy substituent.		hp.json	hydroxybutyric acids|hydroxybutanoic acid|hydroxybutanoic acids	http://purl.obolibrary.org/obo/CHEBI_24684		3_STAR
UBERON:0001469	biolink:AnatomicalEntity	sternoclavicular joint	The sternoclavicular articulation is a double arthrodial joint composed of two portions separated by an articular disc. The parts entering into its formation are the sternal end of the clavicle, the upper and lateral part of the manubrium sterni, and the cartilage of the first rib, visible from the outside as the suprasternal notch. The articular surface of the clavicle is much larger than that of the sternum, and is invested with a layer of cartilage, which is considerably thicker than that on the latter bone. The ligaments of this joint are: Articular capsule Anterior sternoclavicular ligament Posterior sternoclavicular ligament Interclavicular ligament Costoclavicular ligament Articular disk [WP,unvetted].	EMAPA:19203|MESH:D013247|OpenCyc:Mx4rwI-ZZpwpEbGdrcN5Y29ycA|GAID:270|MA:0001507|OpenCyc:Mx4rv_eLJZwpEbGdrcN5Y29ycA|NCIT:C33615|FMA:25883|UMLS:C0038291	hp.json	sternoclavicular articulation|sterno clavicular joint|articulatio sternoclavicularis|sternoclavicular	http://purl.obolibrary.org/obo/UBERON_0001469		uberon_slim
UBERON:0013455	biolink:AnatomicalEntity	spheno-petrosal fissure	The sphenopetrosal fissure (or sphenopetrosal suture) is the cranial suture between the sphenoid bone and the petrous portion of the temporal bone. It is in the middle cranial fossa.	FMA:75038	hp.json	sphenopetrosal fissure|fissura sphenopetrosa	http://purl.obolibrary.org/obo/UBERON_0013455		
HP:0032795	biolink:PhenotypicFeature	Generalized myoclonic-tonic-clonic seizure	A generalized myoclonic-tonic-clonic seizure is a type of generalized motor seizure characterised by a single or multiple jerks of limbs bilaterally, followed by tonic and clonic phases. The initial jerks can be considered to be either a brief period of clonus or myoclonus.		hp.json	generalised onset myoclonic-tonic-clonic seizure|Generalised onset myoclonic-tonic-clonic seizure|Generalised-onset myoclonic-tonic-clonic seizure|generalized onset myoclonic-tonic-clonic seizure|Generalized-onset myoclonic-tonic-clonic seizure|Generalised myoclonic-tonic-clonic seizure	http://purl.obolibrary.org/obo/HP_0032795		
HP:0030132	biolink:PhenotypicFeature	Absence of large von Willibrand factor multimers	Absence of large von Willebrand Factor multimers on gel electrophoresis.	UMLS:C4022616	hp.json		http://purl.obolibrary.org/obo/HP_0030132		
HP:0032794	biolink:PhenotypicFeature	Myoclonic seizure	A myoclonic seizure is a type of motor seizure characterised by sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus.		hp.json		http://purl.obolibrary.org/obo/HP_0032794		
HP:0030133	biolink:PhenotypicFeature	Abnormal presence of ultra-large von Willebrand factor multimers	Detection of abnormal ultra-large von Willebrand factor multimers.	UMLS:C4022615	hp.json		http://purl.obolibrary.org/obo/HP_0030133		
HP:0032797	biolink:PhenotypicFeature	Focal aware sensory seizure with olfactory features	Seizures characterized by olfactory phenomena at onset - usually an odor, which is often unpleasant.		hp.json		http://purl.obolibrary.org/obo/HP_0032797		
HP:0030134	biolink:PhenotypicFeature	Total absence von Willebrand factor multimers	Complete absence of all von Willebrand factor multimers.	UMLS:C4022614	hp.json		http://purl.obolibrary.org/obo/HP_0030134		
PATO:0001654	biolink:NamedThing	misaligned with	An alignment quality inhering in a bearer by virtue of the bearer's being in a improper spatial positioning with respect to an additional entity.		hp.json	misaligned|unaligned with	http://purl.obolibrary.org/obo/PATO_0001654		relational_slim|value_slim
HP:0032796	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with left-right confusion	A focal cognitive seizure with left-right confusion characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032796		
HP:0030135	biolink:PhenotypicFeature	Absence of intermediate von Willibrand factor multimers	Lack of intermediate von Willebrand Factor multimers on gel electrophoresis.	UMLS:C4022613	hp.json		http://purl.obolibrary.org/obo/HP_0030135		
HP:0032791	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with anomia	A focal cognitive seizure with anomia characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032791		
HP:0032790	biolink:PhenotypicFeature	Focal impaired awareness behavior arrest seizure	A focal behavior arrest seizure characterised by impaired awareness at some point during the seizure.		hp.json	Focal impaired awareness behaviour arrest seizure	http://purl.obolibrary.org/obo/HP_0032790		
HP:0032793	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with receptive dysphasia/aphasia	A focal cognitive seizure with receptive dysphasia / aphasia characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032793		
HP:0030130	biolink:PhenotypicFeature	Impaired von Willibrand factor collagen binding activity	Reduced ability of von Willibrand factor (vWF) to bind collagen. Abnormal response to collagen as manifested by reduced or lacking ability of plasma von WIllebrand Factor to bind collagen. An ELISA-based assay is typically used; the test is sensitive to loss of von Willebrand Factor high molecular weight multimers.	UMLS:C4022618	hp.json		http://purl.obolibrary.org/obo/HP_0030130		
HP:0032792	biolink:PhenotypicFeature	Tonic seizure	A tonic seizure is a type of motor seizure characterised by unilateral or bilateral limb stiffening or elevation, often with neck stiffening.		hp.json		http://purl.obolibrary.org/obo/HP_0032792		
HP:0030131	biolink:PhenotypicFeature	Abnormal von Willebrand factor multimer distribution	Deviation from the normal von Willebrand factor multimer pattern.	UMLS:C4022617	hp.json		http://purl.obolibrary.org/obo/HP_0030131		
UBERON:0001471	biolink:AnatomicalEntity	skin of prepuce of penis	The loose fold of skin that covers the penis.	FMA:27648|MA:0001744|VHOG:0001342|EV:0100109	hp.json	penis foreskin|preputial skin|foreskin of penis	http://purl.obolibrary.org/obo/UBERON_0001471		pheno_slim
UBERON:0001470	biolink:AnatomicalEntity	glenohumeral joint	The glenohumeral joint, commonly known as the shoulder joint, is a multiaxial synovial ball and socket joint and involves articulation between the glenoid fossa of the scapula (shoulder blade) and the head of the humerus (upper arm bone). [WP,unvetted].	FMA:25912|MA:0000459|OpenCyc:Mx4rwP32BZwpEbGdrcN5Y29ycA|VHOG:0001002|GAID:269|NCIT:C33548|UMLS:C0037009|EMAPA:19105|galen:ShoulderJoint|MESH:D012785	hp.json	joint of shoulder|articulatio humeri|humeroscapular joint|shoulder joint|humeral joint	http://purl.obolibrary.org/obo/UBERON_0001470		uberon_slim
PATO:0001651	biolink:NamedThing	decreased resistance to	A resistance to a stimulus which is relatively low.		hp.json	low resistance to|decreased resistance	http://purl.obolibrary.org/obo/PATO_0001651		disposition_slim|relational_slim|value_slim
HP:0032799	biolink:PhenotypicFeature	Focal impaired awareness hemiclonic seizure	A focal hemiclonic seizure in which awareness is impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032799		
HP:0030136	biolink:PhenotypicFeature	Enhanced ristocetin cofactor assay activity	Abnormal response to ristocetin as manifested by increased aggregation of platelets upon addition of low-dose ristocetin to platelet-rich plasma.	UMLS:C4022612	hp.json		http://purl.obolibrary.org/obo/HP_0030136		
PATO:0001652	biolink:NamedThing	alignment	A spatial quality inhering in a bearer by virtue of the bearer's spatial positioning with respect to an additional entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001652		attribute_slim|relational_slim
HP:0030137	biolink:PhenotypicFeature	Prolonged bleeding following circumcision	Bleeding that persists for a longer than usual time following circumcision.	UMLS:C4022611	hp.json	Prolonged bleeding following circumcision	http://purl.obolibrary.org/obo/HP_0030137		
HP:0032798	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with neglect	A focal cognitive seizure with neglect characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032798		
HP:0030138	biolink:PhenotypicFeature	Excessive bleeding from superficial cuts	An abnormally increased degree of bleeding following a superfical injury to the surface of the skin.	UMLS:C4022610	hp.json	Excessive bleeding from superficial cuts	http://purl.obolibrary.org/obo/HP_0030138		
PATO:0001650	biolink:NamedThing	increased resistance to	A resistance to a stimulus which is relatively high.		hp.json	increased resistance|high resistance to	http://purl.obolibrary.org/obo/PATO_0001650		disposition_slim|relational_slim|value_slim
HP:0030139	biolink:PhenotypicFeature	Excessive bleeding after a venipuncture	An abnormal high amount of bleeding following the procedure of taking a blood sample.	UMLS:C4022609	hp.json		http://purl.obolibrary.org/obo/HP_0030139		
UBERON:0001476	biolink:AnatomicalEntity	deltoid	A muscle of shoulder which attaches to the scapula, clavicle and humerus.[FMA,generalized].	EMAPA:18177|VHOG:0000846|MA:0002286|EFO:0001412|FMA:32521|AAO:0010716|EHDAA2:0000339|NCIT:C32446|OpenCyc:Mx4rvVjdc5wpEbGdrcN5Y29ycA|UMLS:C0224234	hp.json	common shoulder muscle|musculus deltoideus|deltoid muscle|musculus deltoideus|m. deltoideus|deltoideus|deltoideus muscle	http://purl.obolibrary.org/obo/UBERON_0001476		pheno_slim|efo_slim|uberon_slim
UBERON:0001479	biolink:AnatomicalEntity	sesamoid bone	A sesamoid element that is composed of bone tissue.	MA:0001375|NCIT:C33541|EHDAA2:0003086|MESH:D012716|FMA:32672|galen:SessamoidBone|EMAPA:36620|AEO:0000086|UMLS:C0036846|GAID:210	hp.json	sesamoid|ossa sesamoidea	http://purl.obolibrary.org/obo/UBERON_0001479		uberon_slim
UBERON:0001473	biolink:AnatomicalEntity	lymphatic vessel	A vessel that contains or conveys lymph, that originates as an interfibrillar or intercellular cleft or space in a tissue or organ, and that if small has no distinct walls or walls composed only of endothelial cells and if large resembles a vein in structure[BTO].	MAT:0000443|TAO:0005105|EFO:0000873|BTO:0000752|VHOG:0001249|UMLS:C0229889|EMAPA:35532|OpenCyc:Mx4rwA1fYZwpEbGdrcN5Y29ycA|MESH:D042601|MA:0000138|CALOHA:TS-2102|XAO:0000375|NCIT:C33038|AAO:0011005|FMA:30315	hp.json	vas lymphaticum|lymph vessel	http://purl.obolibrary.org/obo/UBERON_0001473		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0001472	biolink:AnatomicalEntity	vaginal venous plexus	The vaginal plexuses are placed at the sides of the vagina; they communicate with the uterine, vesical, and hemorrhoidal plexuses, and are drained by the vaginal veins, one on either side, into the hypogastric veins. [WP,unvetted].	FMA:29713|MA:0002257|EMAPA:37801	hp.json	venous vaginal plexus|plexus venosus vaginalis	http://purl.obolibrary.org/obo/UBERON_0001472		uberon_slim
UBERON:0001474	biolink:AnatomicalEntity	bone element	Skeletal element that is composed of bone tissue.	NCIT:C12366|SCTID:90780006|MAT:0000299|AAO:0000047|OpenCyc:Mx4rvVkCG5wpEbGdrcN5Y29ycA|Wikipedia:Bone|VHOG:0001190|UMLS:C0262950|EFO:0000298|MIAA:0000299|VSAO:0000057|galen:Bone|EV:0100140|ZFA:0001514|FMA:5018|EMAPA:32782|MA:0001459|OpenCyc:Mx4rvViDlpwpEbGdrcN5Y29ycA|XAO:0000169|BTO:0000140|TAO:0001514|GAID:92|EHDAA2:0003082|CALOHA:TS-0088|FMA:30317|ENVO:00002039|AEO:0000082	hp.json	bone organ|bone|bones	http://purl.obolibrary.org/obo/UBERON_0001474		pheno_slim|efo_slim|uberon_slim|vertebrate_core|major_organ|organ_slim
UBERON:0001459	biolink:AnatomicalEntity	skin of external ear	A zone of skin that is part of a external ear [Automatically generated definition].	NCIT:C49481|UMLS:C0222110|MA:0001233|FMA:24775|EMAPA:35301	hp.json	zone of skin of auricular region|auricular region zone of skin|zone of skin of external ear|external ear skin|zone of skin of auricular region of head|ear skin|zone of skin of outer ear|auricular region of head zone of skin|external ear zone of skin|outer ear zone of skin	http://purl.obolibrary.org/obo/UBERON_0001459		pheno_slim
UBERON:0001458	biolink:AnatomicalEntity	skin of lip	A zone of skin that is part of a lip [Automatically generated definition].	UMLS:C0222101|EMAPA:37643|FMA:24764|SCTID:244092005|NCIT:C12291|MA:0001579	hp.json	lip zone of skin|lip skin|zone of skin of lip|skin of lips	http://purl.obolibrary.org/obo/UBERON_0001458		
HP:0030143	biolink:PhenotypicFeature	Hyperactive bowel sounds	Abnormally increased gurgling/rumbling sounds made by the movement of fluid and gas in the intestines.	UMLS:C0232694|SNOMEDCT_US:18101008	hp.json	Increased bowel sounds|Borborygmi	http://purl.obolibrary.org/obo/HP_0030143		
HP:0030144	biolink:PhenotypicFeature	Hypoactive bowel sounds	An decreased amount of bowel sounds.	UMLS:C0232695|SNOMEDCT_US:15280003	hp.json	Decreased bowel sounds	http://purl.obolibrary.org/obo/HP_0030144		
HP:0030145	biolink:PhenotypicFeature	Lack of bowel sounds	Complete lack of abdominal sounds as assayed by examination of the abdomen with a stethoscope.	UMLS:C4022606	hp.json	Lack of bowel sounds	http://purl.obolibrary.org/obo/HP_0030145		
HP:0030146	biolink:PhenotypicFeature	Abnormal liver parenchyma morphology	A structural anomaly of the liver located predominantly in the hepatocytes as opposed to stromal cells.	UMLS:C4022605	hp.json		http://purl.obolibrary.org/obo/HP_0030146		
HP:0030140	biolink:PhenotypicFeature	Oral cavity bleeding	Recurrent or excessive bleeding from the mouth.	UMLS:C4022608	hp.json	Oral cavity hemorrhage|Oral cavity bleeding|Bleeding from mouth|Oral cavity haemorrhage	http://purl.obolibrary.org/obo/HP_0030140		
HP:0030141	biolink:PhenotypicFeature	Abnormality of the posterior hairline	An anomaly in the placement or shape of the hairline (trichion) on the back of the head (neck), that is, the border between skin on the back of the head that has head hair.	UMLS:C4022607	hp.json	Abnormality of hairline at back of head	http://purl.obolibrary.org/obo/HP_0030141		
PATO:0001669	biolink:NamedThing	increased susceptibility toward	A susceptibility toward an external stimulus which is higher than normal/average.		hp.json	increased susceptibility|high susceptibility toward	http://purl.obolibrary.org/obo/PATO_0001669		disposition_slim|relational_slim|value_slim
CHEBI:131927	biolink:ChemicalSubstance	dicarboxylic acids and O-substituted derivatives	A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens.		hp.json	dicarboxylic acids and derivatives	http://purl.obolibrary.org/obo/CHEBI_131927		3_STAR
HP:0030142	biolink:PhenotypicFeature	Abnormal bowel sounds	An anomaly of the amount or nature of abdominal sounds. Abdominal sounds (bowel sounds) are made by the movement of the intestines as they promote passage of abdominal contents by peristalsis.	SNOMEDCT_US:60612008|UMLS:C0159060	hp.json	Abnormal bowel sounds	http://purl.obolibrary.org/obo/HP_0030142		
UBERON:0001460	biolink:AnatomicalEntity	arm	The part of the forelimb extending from the shoulder to the autopod[cjm].	VHOG:0000339|BTO:0001435|EFO:0001410|MESH:D001132|EHDAA:6210|EHDAA:4164|EHDAA2:0000140|GAID:52|CALOHA:TS-2204|EHDAA:8275|EMAPA:17413|OpenCyc:Mx4rvVjp5ZwpEbGdrcN5Y29ycA|MA:0000033	hp.json	upper extremity|brachium	http://purl.obolibrary.org/obo/UBERON_0001460		pheno_slim|efo_slim|uberon_slim
HP:0030147	biolink:PhenotypicFeature	Truncal titubation	Tremor of the trunk in an anterior-posterior plane at 3-4 Hz.	UMLS:C2674512	hp.json		http://purl.obolibrary.org/obo/HP_0030147		
PATO:0001662	biolink:NamedThing	fragility	A structural quality inhering in a bearer by virtue of the bearer's disposition to being damaged or destroyed.		hp.json		http://purl.obolibrary.org/obo/PATO_0001662		scalar_slim|disposition_slim|attribute_slim
HP:0030148	biolink:PhenotypicFeature	Heart murmur	An extra or unusual sound heard during a heartbeat caused vibrations resulting from the flow of blood through the heart.	MSH:D006337|SNOMEDCT_US:88610006|SNOMEDCT_US:421493004|UMLS:C0018808|SNOMEDCT_US:414786004	hp.json	Cardiac murmurs|Cardiac murmur|Heart murmur|Heart murmurs	http://purl.obolibrary.org/obo/HP_0030148		
HP:0030149	biolink:PhenotypicFeature	Cardiogenic shock	Severely decreased cardiac output with evidence of inadequate end-organ perfusion (i.e., tissue hypoxia) in the presence of adequate intravascular volume.	MSH:D012770|SNOMEDCT_US:89138009|UMLS:C0036980	hp.json	Cardiovascular shock	http://purl.obolibrary.org/obo/HP_0030149		
UBERON:0001466	biolink:AnatomicalEntity	pedal digit	A digit that is part of a pes (foot).	UMLS:C0040357|EMAPA:32649|galen:Toe|XAO:0003035|BTO:0002348|GAID:44|FMA:25046|NCIT:C33788|MA:0000048|AAO:0000888|OpenCyc:Mx4rvVjCHZwpEbGdrcN5Y29ycA	hp.json	toe|pes digit|hind digit|hind_digit|hindlimb digit|digiti pedis|pedal digit (phalangeal portion) plus soft tissue|digitus pedis|digit of foot|digitipedis|digit of terminal segment of lower limb|digiti pedis|foot digit	http://purl.obolibrary.org/obo/UBERON_0001466		pheno_slim|uberon_slim
UBERON:0001465	biolink:AnatomicalEntity	knee	A segment of the hindlimb that corresponds to the joint connecting a hindlimb stylopod and zeugopod.	EHDAA2:0000895|GAID:48|EHDAA:5159|EMAPA:17493|OpenCyc:Mx4rvVjPKZwpEbGdrcN5Y29ycA|VHOG:0000347|FMA:24974|galen:Knee|BTO:0003595|EHDAA:6184|MESH:D007717|MA:0000046|CALOHA:TS-2220	hp.json	knee region	http://purl.obolibrary.org/obo/UBERON_0001465		pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0001468	biolink:AnatomicalEntity	intervertebral joint	The joint between adjacent vertebral bodies. May be composed of the nucleus pulposus, annular ligament, and the anterior and posterior longitudinal ligaments.	EMAPA:37622|NCIT:C49577|FMA:25511|MA:0001514|UMLS:C1182940	hp.json	vertebral joint|inter-centrum joint|inter-vertebral joint|intervertebral symphysis|joint of vertebral body	http://purl.obolibrary.org/obo/UBERON_0001468		
UBERON:0001467	biolink:AnatomicalEntity	shoulder	A subdivision of the pectoral complex consisting of the structures in the region of the shoulder joint (which connects the humerus, scapula and clavicle).	EHDAA:6228|NCIT:C25203|MESH:D012782|CALOHA:TS-2229|OpenCyc:Mx4rvViCM5wpEbGdrcN5Y29ycA|UMLS:C0037004|EFO:0003068|FMA:25202|VHOG:0000342|GAID:60|MA:0000038|galen:Shoulder|EHDAA2:0001834|EHDAA:4180|EMAPA:17421	hp.json	articulatio humeri|shoulder region	http://purl.obolibrary.org/obo/UBERON_0001467		pheno_slim|efo_slim|uberon_slim
RO:0017001	biolink:NamedThing	utilizes	X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y.		hp.json	utilizes	http://purl.obolibrary.org/obo/RO_0017001		
UBERON:0001461	biolink:AnatomicalEntity	elbow	The elbow is the region surrounding the elbow-joint-the ginglymus or hinge joint in the middle of the arm. Three bones form the elbow joint: the humerus of the upper arm, and the paired radius and ulna of the forearm. The bony prominence at the very tip of the elbow is the olecranon process of the ulna, and the inner aspect of the elbow is called the antecubital fossa. [WP,unvetted,human-specific].	FMA:24901|EHDAA:4166|EHDAA:6212|EFO:0003069|galen:Elbow|GAID:54|MESH:D004550|EHDAA2:0000429|EMAPA:17414|VHOG:0000340|OpenCyc:Mx4rvVjjNZwpEbGdrcN5Y29ycA|CALOHA:TS-2222|MA:0000036	hp.json	articulatio cubiti|elbow limb segment|elbow region|cubital region	http://purl.obolibrary.org/obo/UBERON_0001461		pheno_slim|efo_slim|uberon_slim
UBERON:0001464	biolink:AnatomicalEntity	hip	The hip region is located lateral to the gluteal region (i.e. the buttock), inferior to the iliac crest, and overlying the greater trochanter of the thigh bone. In adults, three of the bones of the pelvis have fused into the hip bone which forms part of the hip region. The hip joint, scientifically referred to as the acetabulofemoral joint (art. coxae), is the joint between the femur and acetabulum of the pelvis and its primary function is to support the weight of the body in both static (e.g. standing) and dynamic (e.g. walking or running) postures. [WP,modified].	MESH:D006615|MA:0000045|EHDAA2:0000783|GAID:47|UMLS:C0019552|BTO:0001457|EHDAA:6178|FMA:24964|VHOG:0000346|EMAPA:17490|NCIT:C64193|EHDAA:5153|EFO:0001929|CALOHA:TS-2226|galen:Hip|OpenCyc:Mx4rvVjhy5wpEbGdrcN5Y29ycA	hp.json	regio coxae|coxa|hip region	http://purl.obolibrary.org/obo/UBERON_0001464		pheno_slim|efo_slim|uberon_slim
UBERON:0001463	biolink:AnatomicalEntity	manual digit 1	1st (preaxial) digit of the manus[Wikipedia].	UMLS:C0040067|GAID:58|EMAPA:17429|NCIT:C52834|AAO:0010639|MESH:D013933|MA:0000454|FMA:24938|EHDAA2:0000511|OpenCyc:Mx4rvVjVbpwpEbGdrcN5Y29ycA	hp.json	hand digit 1|thumb|manual digit I|digitus I|digit 1 of fore-paw|first digit of hand|fore limb digit 1|manual digit 1|alula|pollex|fore digit I|hand digit 1|digitus 1|digit 1 of manus|first finger|finger 1|forelimb dewclaw|digitus primus|digitus primus [I]	http://purl.obolibrary.org/obo/UBERON_0001463		pheno_slim|uberon_slim
CHEBI:24663	biolink:ChemicalSubstance	hydroxy-5beta-cholanic acid	Any member of the class of 5beta-cholanic acids carrying at least one hydroxy group at unspecified position.		hp.json	hydroxy-5beta-cholanic acids	http://purl.obolibrary.org/obo/CHEBI_24663		3_STAR
CHEBI:24662	biolink:ChemicalSubstance	hydroxy-amino acid	A non-proteinogenic alpha-amino acid bearing one or more hydroxy groups at unspecified positions.		hp.json		http://purl.obolibrary.org/obo/CHEBI_24662		3_STAR
UBERON:0001448	biolink:AnatomicalEntity	metatarsal bone	The metatarsus or metatarsal bones are a group of five long bones in the pes located between the tarsal bones of the hind- and mid-pes and the phalanges of the toes. Lacking individual names, the metatarsal bones are numbered from the medial side (side of big toe): the first, second, third, fourth, and fifth metatarsal. The metatarsals are analogous to the metacarpal bones of the manus. [WP,unvetted].	MA:0000303|MESH:D008682|galen:Metatarsal|FMA:24492|NCIT:C12752|BTO:0002347|GAID:193|EMAPA:32940|UMLS:C0025584|EMAPA:36159	hp.json	ossa metatarsi|metatarsal|ossa metatarsalia	http://purl.obolibrary.org/obo/UBERON_0001448		uberon_slim|pheno_slim
CHEBI:24669	biolink:ChemicalSubstance	hydroxy carboxylic acid	Any carboxylic acid with at least one hydroxy group.		hp.json	hydroxycarboxylic acids|hydroxy carboxylic acids|hydroxycarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_24669		3_STAR
UBERON:0001447	biolink:AnatomicalEntity	tarsal bone	A bone that is part of the tarsal skeleton. Examples: calcaneus, talus, centralia.	galen:TarsalBone|NCIT:C12796|MA:0000297|FMA:24491|EMAPA:25072|GAID:194|UMLS:C0039316|BTO:0002343|MESH:D013639	hp.json	tarsus osseus|bone of ankle|bone of tarsus|hind mesopodium|bony tarsus|bone of tarsal skeleton|ossa tarsalia|ossa tarsi|ankle bone|tarsal	http://purl.obolibrary.org/obo/UBERON_0001447		uberon_slim|pheno_slim
UBERON:0001449	biolink:AnatomicalEntity	phalanx of pes	A phalanx that is part of a hindlimb autopod[Automatically generated definition].	FMA:24493|NCIT:C52772|AAO:0000930|ncithesaurus:Phalanx_of_the_Foot|EMAPA:32941|UMLS:C0584876|MA:0000305	hp.json	toe phalanx|pedal phalanx|phalanx of toe|digital bone of pes|bone of toe|phalanx of pes|digitus pedis phalanx|phalanx of foot digit|phalanges of hind digit|phalanx of hind digit|foot phalanx|foot digit phalanx|phalanx of digitus pedis|phalanx of digit of foot	http://purl.obolibrary.org/obo/UBERON_0001449		pheno_slim
HP:0030154	biolink:PhenotypicFeature	Gallbladder perforation	Rupture of the wall of the gallbladder.	SNOMEDCT_US:25345001|UMLS:C0156215	hp.json	Gall bladder perforation	http://purl.obolibrary.org/obo/HP_0030154		
HP:0030155	biolink:PhenotypicFeature	Scrotal pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the scrotum.	UMLS:C0236078|SNOMEDCT_US:20502007	hp.json	Scrotal pain	http://purl.obolibrary.org/obo/HP_0030155		
HP:0030156	biolink:PhenotypicFeature	Bence Jones Proteinuria	The presence of free monoclonal immunoglobulin light chains in the urine.	UMLS:C0004968|SNOMEDCT_US:274771005	hp.json		http://purl.obolibrary.org/obo/HP_0030156		
HP:0030157	biolink:PhenotypicFeature	Flank pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the flank.	UMLS:C0016199|MSH:D021501|SNOMEDCT_US:247355005	hp.json	Kidney pain|Flank pain	http://purl.obolibrary.org/obo/HP_0030157		
HP:0030150	biolink:PhenotypicFeature	Plasmacytosis	An abnormally increased number of plasma cells in tissues, exudates, or blood	UMLS:C0549295	hp.json		http://purl.obolibrary.org/obo/HP_0030150		
CHEBI:83039	biolink:ChemicalSubstance	crustacean metabolite	An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill.		hp.json	crustacean metabolites	http://purl.obolibrary.org/obo/CHEBI_83039		3_STAR
CHEBI:83038	biolink:ChemicalSubstance	Daphnia galeata metabolite	A Daphnia metabolite produced by the species Daphnia galeata.		hp.json	Daphnia galeata metabolites	http://purl.obolibrary.org/obo/CHEBI_83038		3_STAR
HP:0030151	biolink:PhenotypicFeature	Cholangitis	Inflammation of the biliary ductal system, affecting the intrahepatic or extrahepatic portions, or both.	UMLS:C0008311|MSH:D002761|SNOMEDCT_US:82403002	hp.json	Bile duct inflammation	http://purl.obolibrary.org/obo/HP_0030151		
HP:0030152	biolink:PhenotypicFeature	obsolete Biliary tract neoplasm			hp.json		http://purl.obolibrary.org/obo/HP_0030152		
HP:0030153	biolink:PhenotypicFeature	Cholangiocarcinoma	Cholangiocarcinoma is a primary cancer originating in the biliary epithelium i.e., the cholangiocytes, of the extrahepatic and intrahepatic biliary ducts. It is extremely invasive, develops rapidly, often metastasizes, and has a very poor prognosis. They are slow growing tumors which spread longitudinally along the bile ducts with neural, perineural and subepithelial extension.	UMLS:C0206698|NCIT:C3262|SNOMEDCT_US:70179006|MSH:D018281|SNOMEDCT_US:312104005	hp.json	Bile duct cancer	http://purl.obolibrary.org/obo/HP_0030153		
PATO:0001670	biolink:NamedThing	decreased susceptibility toward	A susceptibility toward an external stimulus which is lower than normal/average.		hp.json	low susceptibility toward|decreased susceptibility	http://purl.obolibrary.org/obo/PATO_0001670		disposition_slim|relational_slim|value_slim
HP:0030158	biolink:PhenotypicFeature	Cervical ectropion	Cervical ectropion occurs when eversion of the endocervix exposes columnar epithelium to the vaginal milieu	UMLS:C0269189|SNOMEDCT_US:61253004|MSH:D002579|SNOMEDCT_US:79342006|UMLS:C0007869	hp.json	Cervical erosion|Cervical ectopy	http://purl.obolibrary.org/obo/HP_0030158		
PATO:0001673	biolink:NamedThing	cystic	Structure quality that is the presence of at least one sac-like closed membranous structure containing one or more liquid or solid organism substances.		hp.json	cysts	http://purl.obolibrary.org/obo/PATO_0001673		value_slim
HP:0030159	biolink:PhenotypicFeature	Cervical polyp	Abnormal growth of tissue projecting from a mucous membrane of the endocervix.	SNOMEDCT_US:123841004|MSH:D002583|SNOMEDCT_US:65576009|UMLS:C0007855|UMLS:C0007873	hp.json	Cervical tumour|Cervical tumor	http://purl.obolibrary.org/obo/HP_0030159		
GO:0060612	biolink:BiologicalProcess	adipose tissue development	The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.		hp.json	adipogenesis	http://purl.obolibrary.org/obo/GO_0060612		
UBERON:0001455	biolink:AnatomicalEntity	cuboid bone	A tarsal bone that is formed from distal tarsals 4 and 5. [WP,modified].	UMLS:C0376381|EMAPA:36175|MA:0001355|galen:Cuboid|FMA:24527|BTO:0002357|NCIT:C32414	hp.json	cuboideum|os tarsale IV et V|cuboid|foot distal tarsal bone 4 and 5|distal tarsal bones 4 and 5|os cuboideum	http://purl.obolibrary.org/obo/UBERON_0001455		uberon_slim
UBERON:0001454	biolink:AnatomicalEntity	distal tarsal bone 3	Endochondral tarsal bone articulating with centralia and metatarsal 3.	NCIT:C32554|galen:LateralCuneiform|AAO:0000920|MA:0001354|VSAO:0005054|BTO:0002358|FMA:24520|OpenCyc:Mx4rvoLPu5wpEbGdrcN5Y29ycA|EMAPA:36178|UMLS:C1517036	hp.json	distal tarsal 3|os tarsale III|external cuneiform bone of foot|os cuneiforme laterale|cuneiforme 3|lateral cuneiform|lateral cuneiform bone|external cuneiform|third cuneiform bone|distal tarsal 3 bone|3rd cuneiform|os cuneiforme tertium|ossa cuneiforme laterale|os cuneiforme laterale|tarsal 3|ectocuneiforme|foor distal carpal bone 3	http://purl.obolibrary.org/obo/UBERON_0001454		uberon_slim
UBERON:0001457	biolink:AnatomicalEntity	skin of eyelid	A zone of skin that is part of a eyelid [Automatically generated definition].	MA:0001256|EMAPA:37536|NCIT:C52718|UMLS:C0222088|FMA:24760	hp.json	blepharon zone of skin|eyelid zone of skin|zone of skin of blepharon|eyelid skin|zone of skin of eyelid	http://purl.obolibrary.org/obo/UBERON_0001457		pheno_slim
UBERON:0001456	biolink:AnatomicalEntity	face	A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc).	galen:Face|FMA:24728|MA:0002473|SCTID:302549007|BTO:0003369|EMAPA:32763|MESH:D005145|HAO:0000316|UMLS:C0015450|CALOHA:TS-2216|GAID:64|OpenCyc:Mx4rvVi5GZwpEbGdrcN5Y29ycA|Wikipedia:Face|NCIT:C13071	hp.json	facia/facies|visage|facia/facies	http://purl.obolibrary.org/obo/UBERON_0001456		pheno_slim|uberon_slim
UBERON:0001451	biolink:AnatomicalEntity	navicular bone of pes	The oval-shaped tarsal bone found between the talus and the 3 cuneiform bones.	OpenCyc:Mx4rv67esJwpEbGdrcN5Y29ycA|galen:Navicular|EMAPA:36180|BTO:0002356|NCIT:C33162|FMA:24499|MA:0001349|UMLS:C0223947|AAO:0000924	hp.json	navicular of foot|centrale (hind)|central tarsal bone|os naviculare|navicular bone of foot|navicular|centrale|os tarsi centrale|os naviculare pedis|os naviculare|navicular of pes	http://purl.obolibrary.org/obo/UBERON_0001451		pheno_slim|uberon_slim
UBERON:0001450	biolink:AnatomicalEntity	calcaneus	The postaxial bone of the proximal tarsals series[Phenoscape].	EMAPA:19134|MESH:D002111|NCIT:C32250|BTO:0002355|VSAO:0005016|UMLS:C0006655|MA:0001348|FMA:24496|galen:Calcaneum	hp.json	calcaneum|heel bone|calcanei|os tarsi fibulare|os calcis|calcaneal bone|fibulare|calcaneus bone	http://purl.obolibrary.org/obo/UBERON_0001450		pheno_slim|uberon_slim
UBERON:0001453	biolink:AnatomicalEntity	distal tarsal bone 2	Endochondral tarsal bone articulating with centralia and metatarsal 2.	galen:IntermediateCuneiform|FMA:24519|MA:0001353|VSAO:0005053|BTO:0002359|AAO:0000919|UMLS:C1513292|EMAPA:36177|NCIT:C33116	hp.json	foot distal carpal bone 2|mesocuneiforme|intermediate cuneiform|distal tarsal 2|os cuneiforme intermedium|second cuneiform bone|2nd cuneiform|cuneiforme 2|os cuneiforme secundum|distal tarsal 2 bone|middle cuneiform|intermediate cuneiform bone|tarsal 2|os cuneiforme intermedium|os cuneiforme secundum|os tarsale II|second cuneiform bone of foot|middle cuneiform bone of foot|os cuneiforme intermedium	http://purl.obolibrary.org/obo/UBERON_0001453		uberon_slim
UBERON:0001452	biolink:AnatomicalEntity	distal tarsal bone 1	Endochondral tarsal bone articulating with centralia and metatarsal 1.	NCIT:C32840|FMA:24518|MA:0001352|VSAO:0005052|AAO:0000918|OpenCyc:Mx4rvYtfH5wpEbGdrcN5Y29ycA|BTO:0002360|galen:MedialCuneiform|UMLS:C1512869|EMAPA:36176	hp.json	entocuneiforme|os cuneiforme mediale|distal tarsal 1|first cuneiform|foot distal carpal bone 1|os tarsale I|ossa cuneiforme mediale|cuneiforme 1|distal tarsal 1 bone|first cuneiform bone|1st cuneiform|tarsal 1|os cuneiforme mediale|os cuneiforme mediale|medial cuneiform|os cuneiform primum|os cuneiforme primum|medial cuneiform bone	http://purl.obolibrary.org/obo/UBERON_0001452		uberon_slim
HP:0030160	biolink:PhenotypicFeature	Cervicitis	Inflammation of the uterine cervix.	UMLS:C0007860|MSH:D002575|SNOMEDCT_US:37610005	hp.json	Uterine cervix inflammation|Uterine cervicitis	http://purl.obolibrary.org/obo/HP_0030160		
UBERON:0001437	biolink:AnatomicalEntity	epiphysis	The head of a long bone that articulates with a neighboring skeletal element and is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united[MESH,modified].	NCIT:C52722|MESH:D004838|FMA:24012|EMAPA:35508|AAO:0000742|BTO:0000413|MA:0001362|UMLS:C1708734|NCIT:C32529	hp.json	long bone epiphysis|bone epiphysis|epiphyses|end of long bone	http://purl.obolibrary.org/obo/UBERON_0001437		uberon_slim|pheno_slim
UBERON:0001436	biolink:AnatomicalEntity	phalanx of manus	A phalanx that is part of a forelimb autopod[Automatically generated definition].	EMAPA:32650|AAO:0000947|NCIT:C52771|FMA:23914|UMLS:C0223792|MA:0000306	hp.json	phalanx of digitus manus|finger phalanx|phalanx of finger|phalanx of hand|manual phalanx|phalanx of hand digit|digitus manus phalanx|phalanx of fore digit|digital bone of manus|bone of finger|hand phalanx|hand digit phalanx|phalanx of digit of hand|phalanx of manual digit|phalanges of fore digit	http://purl.obolibrary.org/obo/UBERON_0001436		pheno_slim
UBERON:0001439	biolink:AnatomicalEntity	compact bone tissue	The outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae.	UMLS:C0222661|EMAPA:35250|MA:0001461|galen:CorticalBone|FMA:24018|NCIT:C52714	hp.json	substantia compacta (pars ossea)|compact bone tissue|cortical bone tissue|substantia compacta|substantia corticalis|cortical bone|cortical region of bone|compact bone|bony cortex	http://purl.obolibrary.org/obo/UBERON_0001439		uberon_slim|pheno_slim
UBERON:0001438	biolink:AnatomicalEntity	metaphysis	Zone of long bone that is between the epiphysis and diaphysis. Subdivision of diaphysis which forms the proximal or distal end of diaphysis next to the epiphysis; together with diaphysis proper, it constitutes the diaphysis. Examples: proximal metaphysis of humerus, distal metaphysis of femur.[FMA].	UMLS:C0222671|NCIT:C52723|FMA:24014|EMAPA:35509|MA:0001363	hp.json	diaphyseal end of long bone|metaphyses|long bone metaphysis	http://purl.obolibrary.org/obo/UBERON_0001438		uberon_slim|pheno_slim
HP:0030165	biolink:PhenotypicFeature	Temporal artery tortuosity	The presence of an increased number of twists and turns of the temporal artery.	UMLS:C4022602	hp.json		http://purl.obolibrary.org/obo/HP_0030165		
HP:0030166	biolink:PhenotypicFeature	Night sweats	Occurrence of excessive sweating during sleep.	SNOMEDCT_US:42984000|UMLS:C0028081	hp.json	Nocturnal hyperhidrosis|Night sweats	http://purl.obolibrary.org/obo/HP_0030166		
UBERON:0013424	biolink:AnatomicalEntity	anatomical point connecting sagittal and lambdoidal sutures	The occipital angle is rounded and corresponds with the point of meeting of the sagittal and lambdoidal sutures-a point which is termed the lambda (after the Greek letter of the same name); in the fetus this part of the skull is membranous, and is called the posterior fontanelle.	FMA:264773	hp.json	lambda|posterior fontanelle	http://purl.obolibrary.org/obo/UBERON_0013424		
HP:0030167	biolink:PhenotypicFeature	Antimitochondrial antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against mitochondria.	UMLS:C4021051	hp.json	Serum antimitochrondrial antibodies	http://purl.obolibrary.org/obo/HP_0030167		
HP:0030168	biolink:PhenotypicFeature	Dilated superficial abdominal veins	Increase in diameter of the veins located underneath the skin of the abdomen.	UMLS:C4021050	hp.json	Dilatation of the superficial abdominal veins	http://purl.obolibrary.org/obo/HP_0030168		
HP:0030161	biolink:PhenotypicFeature	Vaginal pruritus	A sensation of itching in the vagina.	UMLS:C0042256|SNOMEDCT_US:34363003	hp.json		http://purl.obolibrary.org/obo/HP_0030161		
HP:0030162	biolink:PhenotypicFeature	Glomerulomegaly	Abnormally large size of glomeruli.	UMLS:C4022604	hp.json		http://purl.obolibrary.org/obo/HP_0030162		
HP:0030163	biolink:PhenotypicFeature	Abnormal vascular physiology	Abnormality of vascular function.	UMLS:C4022603	hp.json		http://purl.obolibrary.org/obo/HP_0030163		
HP:0030164	biolink:PhenotypicFeature	Jaw claudication	Pain in the jaw or ear induced by chewing or otherwise moving the jaw.	SNOMEDCT_US:43922008|UMLS:C0239064	hp.json	Jaw pain while chewing	http://purl.obolibrary.org/obo/HP_0030164		
HP:0030169	biolink:PhenotypicFeature	Gastric varix	Extreme dilation of the submucusoal veins in the stomach.	UMLS:C0017145|MSH:D004932|SNOMEDCT_US:91109007	hp.json	Gastric varices	http://purl.obolibrary.org/obo/HP_0030169		
UBERON:0001444	biolink:AnatomicalEntity	subdivision of head		XAO:0000040|FMA:24218|SCTID:123852005	hp.json	head region|head subdivision|region of head	http://purl.obolibrary.org/obo/UBERON_0001444		non_informative
UBERON:0001443	biolink:AnatomicalEntity	chest	Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper[FMA].	GAID:91|NCIT:C12799|UMLS:C1527391|galen:Thorax|EFO:0000965|FMA:9576|NCIT:C25389|MA:0000031|OpenCyc:Mx4rvVikFZwpEbGdrcN5Y29ycA|MESH:D013909|BTO:0001368|EV:0100010|UMLS:C0817096|MAT:0000295|CALOHA:TS-1039|EMAPA:37232|galen:Chest|MIAA:0000295	hp.json	thoracic body wall|thorax|front of thorax|anterolateral part of thorax|ventral part of thoracic region|thorax|pectus	http://purl.obolibrary.org/obo/UBERON_0001443		pheno_slim|efo_slim|uberon_slim
UBERON:0001446	biolink:AnatomicalEntity	fibula	The major postaxial endochondral bone in the posterior zeugopod[Phenoscape].	MESH:D005360|GAID:202|EFO:0003052|galen:Fibula|UMLS:C0016068|BTO:0002346|EMAPA:19141|MA:0001360|AAO:0000891|NCIT:C12718|FMA:24479|CALOHA:TS-2203	hp.json		http://purl.obolibrary.org/obo/UBERON_0001446		pheno_slim|efo_slim|uberon_slim
GO:0060605	biolink:BiologicalProcess	tube lumen cavitation	The formation of a lumen by hollowing out a solid rod or cord.		hp.json		http://purl.obolibrary.org/obo/GO_0060605		
UBERON:0001445	biolink:AnatomicalEntity	skeleton of pes	Subdivision of skeleton that is the collection of all skeletal elements in a pes, which is the distal section of the posterior hindlimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the ankle, sole, and toes)[Phenoscape].	EHDAA2:0002228|VSAO:0005021|FMA:24222	hp.json	foot skeleton|posterior autopodium skeleton|pes skeleton|set of bones of foot|foot region skeleton|pes|skeleton of foot|posterior autopodium|pedal skeleton	http://purl.obolibrary.org/obo/UBERON_0001445		pheno_slim
GO:0060606	biolink:BiologicalProcess	tube closure	Creation of the central hole of a tube in an anatomical structure by sealing the edges of an epithelial fold.		hp.json		http://purl.obolibrary.org/obo/GO_0060606		
UBERON:0001440	biolink:AnatomicalEntity	forelimb skeleton	The collection of all skeletal elements in a free forelimb region. Excludes the pectoral girdle.	FMA:24142|AAO:0000202|EMAPA:32623|EHDAA2:0002222|XAO:0003061|VHOG:0001256|VSAO:0000151	hp.json	forelimb skeleton|set of bones of upper limb|free upper limb skeleton|ossa membri superioris|wing skeleton|skeleton of pectoral limb|bones of upper limb|upper limb skeleton|fore limb skeleton|skeleton of forelimb|skeleton of upper limb|skeleton of free upper limb|pectoral limb skeleton	http://purl.obolibrary.org/obo/UBERON_0001440		
PR:O35305	biolink:Protein	tumor necrosis factor receptor superfamily member 11A (mouse)	A tumor necrosis factor receptor superfamily member 11A that is encoded in the genome of mouse.	UniProtKB:O35305	hp.json	mTNFRSF11A|ODFR (mouse)|osteoclast differentiation factor receptor (mouse)|CD265 (mouse)|Tnfrsf11a|Rank|receptor activator of NF-KB (mouse)	http://purl.obolibrary.org/obo/PR_O35305		
UBERON:0001442	biolink:AnatomicalEntity	skeleton of manus	Subdivision of skeleton that is the collection of all skeletal elements in a manus, which is the distal section of the anterior forelimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the wrist, palm, and fingers)[Phenoscape].	EHDAA2:0002227|VSAO:0005020|OpenCyc:Mx4rvdHPJJwpEbGdrcN5Y29ycA|EMAPA:32643|FMA:24159	hp.json	manus|ossa manus|hand region skeleton|hand skeleton|fore autopod skeleton|set of bones of hand|anterior autopodium skeleton|forelimb autopod skeleton|anterior autopodium|manual skeleton|bones of hand|manus skeleton|skeleton of hand	http://purl.obolibrary.org/obo/UBERON_0001442		pheno_slim
GO:0060609	biolink:BiologicalProcess	apoptotic process involved in tube lumen cavitation	Any apoptotic process that contributes to the hollowing out of an epithelial rod or cord to form the central hole in a tube.		hp.json	apoptosis involved in tube lumen cavitation	http://purl.obolibrary.org/obo/GO_0060609		
UBERON:0001441	biolink:AnatomicalEntity	hindlimb skeleton	Subdivision of skeleton consisting of all skeletal elements in an hindlimb region.	OpenCyc:Mx4rvZcKkZwpEbGdrcN5Y29ycA|AAO:0000217|EHDAA2:0002226|EMAPA:32633|XAO:0003062|VHOG:0001255|FMA:24144|VSAO:0000152	hp.json	hind limb skeleton|set of bones of lower limb|skeleton of lower limb|lower limb skeleton|free lower limb skeleton|bones of lower limb|hind-limb skeleton|hindlimb skeleton|ossa membri inferioris|skeleton of free lower limb	http://purl.obolibrary.org/obo/UBERON_0001441		uberon_slim
PATO:0001619	biolink:NamedThing	decreased tonicity	A tonicity which is relatively low.		hp.json	low tonicity	http://purl.obolibrary.org/obo/PATO_0001619		disposition_slim|value_slim
PATO:0001617	biolink:NamedThing	deformed	A morphological quality inhering in a bearer by virtue of the bearer's being distorted in form.		hp.json	disfigured|distorted	http://purl.obolibrary.org/obo/PATO_0001617		value_slim
PATO:0001618	biolink:NamedThing	increased tonicity	A tonicity which is relatively high.		hp.json	high tonicity	http://purl.obolibrary.org/obo/PATO_0001618		disposition_slim|value_slim
HP:0032751	biolink:PhenotypicFeature	Focal impaired awareness emotional seizure with crying	Focal emotional seizure with crying in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032751		
HP:0032750	biolink:PhenotypicFeature	Focal impaired awareness emotional seizure with laughing	Focal emotional seizure with laughing in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032750		
HP:0032753	biolink:PhenotypicFeature	Focal impaired awareness emotional seizure with agitation	A focal emotional seizure with agitation in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032753		
HP:0032752	biolink:PhenotypicFeature	Focal impaired awareness emotional seizure with fear/anxiety/panic	Focal emotional seizure with anxiety, fear or panic as an expressed or observed emotion at the outset of the seizure, in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032752		
HGNC:8149	biolink:Gene	OPLAH (human)	A protein coding gene OPLAH in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8149		
HP:0032759	biolink:PhenotypicFeature	Focal sensory seizure with vestibular features	A seizure characterized by symptoms of dizziness, spinning, vertigo or sense of rotation as its first clinical manifestation.		hp.json	Partial vestibular seizure|Vestibular aura|Focal vestibular seizure	http://purl.obolibrary.org/obo/HP_0032759		
HP:0005129	biolink:PhenotypicFeature	Congenital hypertrophy of left ventricle		UMLS:C1855901	hp.json		http://purl.obolibrary.org/obo/HP_0005129		
HP:0032758	biolink:PhenotypicFeature	Focal aware myoclonic seizure	A type of focal myoclonic seizure during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032758		
HP:0032755	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure	A focal autonomic seizure characterised by impaired awareness at some point within the seizure.		hp.json	Focal autonomic seizure with altered responsiveness|Localised autonomic seizure with altered responsiveness|Partial autonomic seizure with altered responsiveness|Localized autonomic seizure with altered responsiveness	http://purl.obolibrary.org/obo/HP_0032755		
HP:0032754	biolink:PhenotypicFeature	Focal aware sensory seizure	A focal sensory seizure during which awareness is retained throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032754		
HP:0007787	biolink:PhenotypicFeature	Posterior subcapsular cataract	A type of cataract affecting the posterior pole of lens immediately adjacent to ('beneath') the Lens capsule.	UMLS:C0858617|SNOMEDCT_US:315353005	hp.json	Posterior subcapsular cataracts|Posterior subcapsular opacities of the lens	http://purl.obolibrary.org/obo/HP_0007787		
HP:0032757	biolink:PhenotypicFeature	Focal aware hemiclonic seizure	A focal hemiclonic seizure in which awareness is retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032757		
HP:0032756	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure	A focal cognitive seizure in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032756		
HP:0005121	biolink:PhenotypicFeature	Posterior scalloping of vertebral bodies	An excessive concavity of the posterior surface of one or more vertebral bodies.	UMLS:C1850196	hp.json	Posterior vertebral body scalloping	http://purl.obolibrary.org/obo/HP_0005121		
HP:0007783	biolink:PhenotypicFeature	obsolete Butterfly retinal pigment epithelial dystrophy			hp.json		http://purl.obolibrary.org/obo/HP_0007783		
HP:0007786	biolink:PhenotypicFeature	obsolete Lacunar retinal depigmentation			hp.json		http://purl.obolibrary.org/obo/HP_0007786		
GO:0033002	biolink:BiologicalProcess	muscle cell proliferation	The expansion of a muscle cell population by cell division.		hp.json	myocyte proliferation	http://purl.obolibrary.org/obo/GO_0033002		
HP:0007780	biolink:PhenotypicFeature	Cortical pulverulent cataract	A type of cataract characterized by punctate, dust-like opacities within the cortical region of the lens.	UMLS:C4021568	hp.json	Cataracts, cortical pulverulent	http://purl.obolibrary.org/obo/HP_0007780		
GO:0033001	biolink:CellularComponent	Fc-gamma receptor III complex	A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.		hp.json	immunoglobulin G receptor complex|IgG receptor complex|FcgRIII complex	http://purl.obolibrary.org/obo/GO_0033001		
HP:0007782	biolink:PhenotypicFeature	obsolete Peripheral retinal cone degeneration			hp.json		http://purl.obolibrary.org/obo/HP_0007782		
HP:0005120	biolink:PhenotypicFeature	Abnormal cardiac atrium morphology	Any structural abnormality of a cardiac atrium.	UMLS:C4025246	hp.json	Abnormality of cardiac atrium morphology|Abnormality of heart atrium	http://purl.obolibrary.org/obo/HP_0005120		
PATO:0001628	biolink:NamedThing	insufficient	A wholeness quality inhering in a bearer by virtue of the bearer's lacks enough functionality.		hp.json	inadequate	http://purl.obolibrary.org/obo/PATO_0001628		value_slim
HP:0032762	biolink:PhenotypicFeature	Focal autonomic seizure with pallor/flushing	A type of focal autonomic seizure characterized by changes of the skin as the initial semiological feature.		hp.json		http://purl.obolibrary.org/obo/HP_0032762		
PATO:0001623	biolink:NamedThing	atrophied	A size quality inhering in a bearer by virtue of a part or parts of the bearer's being decreased in size due to reduction in tissue mass through wasting.		hp.json	atrophic	http://purl.obolibrary.org/obo/PATO_0001623		value_slim|mpath_slim
HP:0032761	biolink:PhenotypicFeature	Focal aware autonomic seizure with pallor/flushing	A focal autonomic seizure with pallor / flushing characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032761		
HP:0030100	biolink:PhenotypicFeature	Abnormal muscle fiber alpha sarcoglycan	Deviation from normal in the amount of alpha sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines.	UMLS:C4022645	hp.json	Abnormal muscle fibre alpha sarcoglycan	http://purl.obolibrary.org/obo/HP_0030100		
HP:0030101	biolink:PhenotypicFeature	Absent muscle fiber alpha sarcoglycan	Lack of alpha sarcoglycan in muscle. Immunohistochemistry reveals absent alpha sarcoglycan protein in the muscle biopsy.	UMLS:C4022644	hp.json	Absent muscle fibre alpha sarcoglycan	http://purl.obolibrary.org/obo/HP_0030101		
HP:0032764	biolink:PhenotypicFeature	Focal autonomic seizure with erection	A type of focal autonomic seizure characterised by penile erection as the intial semiological feature.		hp.json		http://purl.obolibrary.org/obo/HP_0032764		
HP:0030102	biolink:PhenotypicFeature	Reduced muscle fiber alpha sarcoglycan	A decreased amount of alpha sarcoglycan in muscle. Immunohistochemistry reveals reduced alpha sarcoglycan protein in the muscle biopsy.	UMLS:C4022643	hp.json	Reduced muscle fibre alpha sarcoglycan	http://purl.obolibrary.org/obo/HP_0030102		
HP:0032763	biolink:PhenotypicFeature	Focal autonomic seizure with pupillary dilation/constriction	A type of focal autonomic seizure characterized by pupillary dilatation or contraction as the initial semiological feature.		hp.json		http://purl.obolibrary.org/obo/HP_0032763		
PATO:0001626	biolink:NamedThing	sufficiency	A structural quality inhering in a bearer by virtue of whether the bearer has enough functionality.		hp.json	adequacy	http://purl.obolibrary.org/obo/PATO_0001626		attribute_slim
PATO:0001624	biolink:NamedThing	decreased functionality	A functionality quality held by the bearer when the latter exhibits decreased ability to perform a regular function(s).		hp.json	low functionality|having decreased function|partial functionality|dysfunction|impaired|dysfunctional|lacks function of type	http://purl.obolibrary.org/obo/PATO_0001624		disposition_slim|value_slim
HP:0032760	biolink:PhenotypicFeature	Focal sensory seizure with hot-cold sensations	A seizure characterized by sensations of feeling hot or cold as its first clinical manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032760		
PATO:0001625	biolink:NamedThing	increased functionality	A functional quality held by the bearer when the latter exhibits increased ability to perform a regular function(s).		hp.json	high functionality	http://purl.obolibrary.org/obo/PATO_0001625		disposition_slim|value_slim
HP:0030107	biolink:PhenotypicFeature	Reduced muscle fiber beta sarcoglycan	Immunohistochemistry reveals reduced beta sarcoglycan protein in the muscle biopsy.	UMLS:C4022638	hp.json	Reduced muscle fibre beta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030107		
HP:0030108	biolink:PhenotypicFeature	Reduced muscle fiber gamma sarcoglycan	Immunohistochemistry reveals reduced gamma sarcoglycan protein in the muscle biopsy.	UMLS:C4022637	hp.json	Reduced muscle fibre gamma sarcoglycan	http://purl.obolibrary.org/obo/HP_0030108		
HP:0032769	biolink:PhenotypicFeature	Focal aware autonomic seizure with hypoventilation/hyperventilation/altered respiration	An autonomic seizure with hypoventilation / hyperventilation / altered respiration characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032769		
HP:0030109	biolink:PhenotypicFeature	Absent muscle fiber gamma sarcoglycan	Immunohistochemistry shows complete lack of gamma sarcoglycan protein in the muscle biopsy.	UMLS:C4022636	hp.json	Absent muscle fibre gamma sarcoglycan	http://purl.obolibrary.org/obo/HP_0030109		
HP:0030103	biolink:PhenotypicFeature	Abnormal muscle fiber beta sarcoglycan	Deviation from normal in the amount of beta sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines.	UMLS:C4022642	hp.json	Abnormal muscle fibre beta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030103		
HP:0007799	biolink:PhenotypicFeature	Conjunctival whitish salt-like deposits	The presence of whitish deposits in the conjunctiva resembling salt. May be related to calcinosis.	UMLS:C1968901	hp.json		http://purl.obolibrary.org/obo/HP_0007799		
HP:0005136	biolink:PhenotypicFeature	Mitral annular calcification	Mitral annular calcification (MAC) results from progressive calcium deposition along and beneath the mitral valve annulus.	UMLS:C1835130	hp.json	Premature calcification of mitral annulus	http://purl.obolibrary.org/obo/HP_0005136		
HP:0032766	biolink:PhenotypicFeature	Focal autonomic seizure with hypoventilation/hyperventilation/altered respiration	A type of focal autonomic seizure characterized by changes in respiratory rate as the initial semiological feature.		hp.json		http://purl.obolibrary.org/obo/HP_0032766		
HP:0030104	biolink:PhenotypicFeature	Abnormal muscle fiber gamma sarcoglycan	Deviation from normal in the amount of gamma sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines.	UMLS:C4022641	hp.json	Abnormal muscle fibre gamma sarcoglycan	http://purl.obolibrary.org/obo/HP_0030104		
HP:0007798	biolink:PhenotypicFeature	obsolete Foveal dystrophy			hp.json		http://purl.obolibrary.org/obo/HP_0007798		
HP:0032765	biolink:PhenotypicFeature	Focal autonomic seizure with urge to urinate/defecate	A type of focal autonomic seizure characterized by an urge to unripe or defecate as the initial semiological feature.		hp.json		http://purl.obolibrary.org/obo/HP_0032765		
HP:0030105	biolink:PhenotypicFeature	Abnormal muscle fiber delta sarcoglycan	Deviation from normal in the amount of delta sarcoglycan in muscle. The alpha, beta, gamma, and delta sarcoglycans are components of the dystrophin-complex. They are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a cluster of conserved cysteines.	UMLS:C4022640	hp.json	Abnormal muscle fibre delta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030105		
HP:0032768	biolink:PhenotypicFeature	Focal aware autonomic seizure with pupillary dilation/constriction	A focal autonomic seizure with pupillary dilation / constriction characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032768		
HP:0030106	biolink:PhenotypicFeature	Absent muscle fiber beta sarcoglycan	Immunohistochemistry shows complete lack of beta sarcoglycan protein in the muscle biopsy.	UMLS:C4022639	hp.json	Absent muscle fibre beta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030106		
HP:0032767	biolink:PhenotypicFeature	Focal autonomic seizure with piloerection	A type of focal autonomic seizure characterized by piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) as the initial semiological feature.		hp.json		http://purl.obolibrary.org/obo/HP_0032767		
HP:0005132	biolink:PhenotypicFeature	Pericardial constriction	Compression of the heart caused by rigid, thickened, or fused pericardial membranes.	UMLS:C0240709	hp.json		http://purl.obolibrary.org/obo/HP_0005132		
HP:0007795	biolink:PhenotypicFeature	Anterior cortical cataract	A cataract that affects the anterior part of the cortex of the lens.	UMLS:C1857308	hp.json		http://purl.obolibrary.org/obo/HP_0007795		
HP:0005133	biolink:PhenotypicFeature	Right ventricular dilatation	Enlargement of the chamber of the right ventricle.	UMLS:C0344893|Fyler:2333|Fyler:1827|SNOMEDCT_US:253522006	hp.json	Dilated heart right ventricle	http://purl.obolibrary.org/obo/HP_0005133		
HP:0005134	biolink:PhenotypicFeature	Absence of the pulmonary valve	Refers to the specific combination of defects with a severely dysplastic pulmonary valve and massively dilated branch pulmonary arteries.	SNOMEDCT_US:6996004|UMLS:C0265831	hp.json	Absent pulmonary valve	http://purl.obolibrary.org/obo/HP_0005134		
HP:0007797	biolink:PhenotypicFeature	Retinal vascular malformation		UMLS:C1861791	hp.json		http://purl.obolibrary.org/obo/HP_0007797		
HP:0005135	biolink:PhenotypicFeature	Abnormal T-wave	An abnormality of the T wave on the electrocardiogram, which mainly represents the repolarization of the ventricles.	UMLS:C4025245	hp.json	T-wave abnormalities|EKG: T-wave abnormalities	http://purl.obolibrary.org/obo/HP_0005135		
HP:0007791	biolink:PhenotypicFeature	Patchy atrophy of the retinal pigment epithelium	Wasting (atrophy) of the retinal pigment epithelium present in small, isolated areas.	UMLS:C4024800	hp.json		http://purl.obolibrary.org/obo/HP_0007791		
HP:0007793	biolink:PhenotypicFeature	Granular macular appearance	Mottled (spotted or blotched with different shades) pigmentary abnormality of the macula lutea.	UMLS:C4024799	hp.json	Macular retinal pigment epithelial mottling	http://purl.obolibrary.org/obo/HP_0007793		
HP:0005130	biolink:PhenotypicFeature	obsolete Restrictive heart failure			hp.json		http://purl.obolibrary.org/obo/HP_0005130		
HP:0007792	biolink:PhenotypicFeature	Microsaccadic pursuit		UMLS:C1843892	hp.json		http://purl.obolibrary.org/obo/HP_0007792		
HP:0030110	biolink:PhenotypicFeature	Absent muscle fiber delta sarcoglycan	Immunohistochemistry shows complete lack of delta sarcoglycan protein in the muscle biopsy.	UMLS:C4022635	hp.json	Absent muscle fibre delta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030110		
HP:0032773	biolink:PhenotypicFeature	Focal autonomic seizure with palpitations/tachycardia/bradycardia/asystole	A type of focal autonomic seizure characterized by changes in heart rate as the initial semiological feature.		hp.json		http://purl.obolibrary.org/obo/HP_0032773		
HP:0030111	biolink:PhenotypicFeature	Reduced muscle fiber delta sarcoglycan	Abnormally reduced amount of delta sarcoglycan in muscle.	UMLS:C4022634	hp.json	Reduced muscle fibre delta sarcoglycan	http://purl.obolibrary.org/obo/HP_0030111		
HP:0032772	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure with piloerection	A Focal autonomic seizure with piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) characterized by impaired awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032772		
HP:0030112	biolink:PhenotypicFeature	Abnormal muscle fiber alpha dystroglycan	A deviation from normal of muscle alpha-dystroglcan expression. Alpha-dystroglycan is a heavily glycosylated peripheral-membrane component of the dystrophin-associated glycoprotein complex (DAPC), which, in addition to laminin alpha2, binds perlecan and agrin in the extracellular matrix, whereas beta-dystroglycan, derived from the same gene, is a transmembrane protein that links to dystrophin intracellularly.	UMLS:C4022633	hp.json	Abnormal muscle fibre alpha dystroglycan	http://purl.obolibrary.org/obo/HP_0030112		
HP:0032775	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure with hypoventilation/hyperventilation/altered respiration	An autonomic seizure with hypoventilation / hyperventilation / altered respiration characterized by impaired awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032775		
HP:0030113	biolink:PhenotypicFeature	Abnormal muscle fiber dysferlin	A deviation from normal in the expression of dysferlin in muscle tissue. Dysferlin is an ubiquitous 230-KDa transmembrane protein involved in calcium-mediated sarcolemma resealing.	UMLS:C4022632	hp.json	Abnormal muscle fibre dysferlin	http://purl.obolibrary.org/obo/HP_0030113		
HP:0032774	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure with urge to urinate/defecate	A focal autonomic seizure with urge to urinate / defecate characterized by impaired awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032774		
HP:0032771	biolink:PhenotypicFeature	Focal autonomic seizure with lacrimation	A type of focal autonomic seizure characterized by lacrimation as the initial semiological feature.		hp.json		http://purl.obolibrary.org/obo/HP_0032771		
HP:0032770	biolink:PhenotypicFeature	Focal aware autonomic seizure with erection	A focal autonomic seizure with erection characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032770		
HP:0005107	biolink:PhenotypicFeature	Abnormal sacrum morphology	An abnormality of the sacral bone.	UMLS:C4025250	hp.json	Abnormality of the sacrum	http://purl.obolibrary.org/obo/HP_0005107		hposlim_core
HP:0030118	biolink:PhenotypicFeature	Reduced muscle fiber emerin	Immunohistochemistry reveals reduced emerin protein in the muscle biopsy.	UMLS:C4022627	hp.json	Reduced muscle fibre emerin	http://purl.obolibrary.org/obo/HP_0030118		
HP:0005108	biolink:PhenotypicFeature	Abnormal intervertebral disk morphology	Any structural abnormality of the intervertebral disk.	UMLS:C4025249	hp.json	Abnormality of the intervertebral disk|Abnormality of the intervertebral disc	http://purl.obolibrary.org/obo/HP_0005108		hposlim_core
HP:0007769	biolink:PhenotypicFeature	Peripheral retinal degeneration		UMLS:C1320640|SNOMEDCT_US:405721006|SNOMEDCT_US:61536007	hp.json		http://purl.obolibrary.org/obo/HP_0007769		
HP:0030119	biolink:PhenotypicFeature	Abnormal muscle fiber calpain-3	A deviation from normal in the amount of calpain-3 in muscle tissue. Calpains are intracellular nonlysosomal cysteine proteases modulated by calcium ions. A typical calpain is a heterodimer composed of two distinct subunits, one large (over 80 kDa) and the other small (30 kDa). While only one gene encoding the small subunit has been demonstrated, there are many genes for the large one. CAPN3 is similar to ubiquitous Calpain 1 and 2 (m-calpain and micro-calpain), but contains specific insertion sequences (NS, IS1 and IS2). Calpains cleave target proteins to modify their properties, rather than breaking down the substrates.	UMLS:C4022626	hp.json	Abnormal muscle fibre calpain-3	http://purl.obolibrary.org/obo/HP_0030119		
HP:0005109	biolink:PhenotypicFeature	Abnormality of the Achilles tendon	An abnormality of the Achilles tendon.	UMLS:C4021642	hp.json	Abnormality of the Achilles tendon|Abnormality of the calcaneal tendon	http://purl.obolibrary.org/obo/HP_0005109		
HP:0005103	biolink:PhenotypicFeature	Calcification of the auricular cartilage	Ossification affecting the external ear cartilage.	UMLS:C1408806	hp.json	Petrified ear|Cartilaginous ossification of pinnae|Ear cartilage calcification|Ossification of pinnae	http://purl.obolibrary.org/obo/HP_0005103		
HP:0030114	biolink:PhenotypicFeature	Absent muscle fiber dysferlin	Immunohistochemistry shows complete lack of dysferlin protein in the muscle biopsy.	UMLS:C4022631	hp.json	Absent muscle fibre dysferlin	http://purl.obolibrary.org/obo/HP_0030114		
HP:0007766	biolink:PhenotypicFeature	Optic disc hypoplasia	Underdevelopment of the optic disc, that is of the optic nerve head, where ganglion cell axons exit the eye to form the optic nerve.	SNOMEDCT_US:373650004|UMLS:C1298695	hp.json	Hypoplastic optic discs|Hypoplastic optic disks	http://purl.obolibrary.org/obo/HP_0007766		
HP:0032777	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure with pallor/flushing	A focal autonomic seizure with pallor / flushing characterized by impaired awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032777		
HP:0005104	biolink:PhenotypicFeature	Hypoplastic nasal septum	Underdevelopment of the nasal septum.	UMLS:C1861328	hp.json	Decreased size of nasal septum|Small septum of nose|Decreased size of septum of nose|Hypoplasia of septum of nose|Small nasal septum	http://purl.obolibrary.org/obo/HP_0005104		
HP:0007765	biolink:PhenotypicFeature	Deep anterior chamber	Increased depth of the anterior chamber, i.e., the anteroposterior distance between the cornea and the iris is increased.	UMLS:C0423280|SNOMEDCT_US:246991003	hp.json		http://purl.obolibrary.org/obo/HP_0007765		
HP:0032776	biolink:PhenotypicFeature	Focal aware autonomic seizure with lacrimation			hp.json		http://purl.obolibrary.org/obo/HP_0032776		
HP:0030115	biolink:PhenotypicFeature	Reduced muscle fiber dysferlin	Immunohistochemistry reveals reduced dysferlin protein in the muscle biopsy.	UMLS:C4022630	hp.json	Reduced muscle fibre dysferlin	http://purl.obolibrary.org/obo/HP_0030115		
GO:0035645	biolink:BiologicalProcess	enteric smooth muscle cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine.		hp.json	intestinal smooth muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0035645		
HP:0032779	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure with pupillary dilation/constriction	A focal autonomic seizure with pupillary dilation / constriction characterized by impaired awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032779		
HP:0030116	biolink:PhenotypicFeature	Abnormal muscle fiber emerin	A deviation from normal of the amount of the inner nuclear membrane protein emerin in muscle tissue.	UMLS:C4022629	hp.json	Abnormal muscle fibre emerin	http://purl.obolibrary.org/obo/HP_0030116		
HP:0007768	biolink:PhenotypicFeature	Central retinal vessel vascular tortuosity	The presence of an increased number of twists and turns of retinal blood vessels (arteries, arterioles, veins, venules).	UMLS:C4021569	hp.json	Tortuosity of main retinal vessels	http://purl.obolibrary.org/obo/HP_0007768		
HP:0005105	biolink:PhenotypicFeature	Abnormal nasal morphology		UMLS:C4025252|Fyler:4870	hp.json	Abnormal nose morphology|Abnormal of shape of nose|Abnormal of nasal shape|Abnormal of morphology of nose	http://purl.obolibrary.org/obo/HP_0005105		
HP:0030117	biolink:PhenotypicFeature	Absent muscle fiber emerin	Immunohistochemistry shows complete lack of emerin protein in the muscle biopsy.	UMLS:C4022628	hp.json	Absent muscle fibre emerin	http://purl.obolibrary.org/obo/HP_0030117		
HP:0005106	biolink:PhenotypicFeature	Abnormality of the vertebral endplates	Any abnormality of the vertebral end plates, which are the top and bottom portions of the vertebral bodies that interface with the vertebral discs.	UMLS:C4025251	hp.json		http://purl.obolibrary.org/obo/HP_0005106		
HP:0032778	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena	A focal autonomic seizure with epigastric sensation / nausea / vomiting / other gastrointestinal phenomena characterized by impaired awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032778		
HP:0005100	biolink:PhenotypicFeature	Premature birth following premature rupture of fetal membranes		UMLS:C1851833	hp.json	Premature birth following premature rupture of foetal membranes	http://purl.obolibrary.org/obo/HP_0005100		
HP:0007761	biolink:PhenotypicFeature	Pericentral scotoma	A scotoma (area of diminished vision within the visual field) that surrounds the central fixation point.	SNOMEDCT_US:404650002|UMLS:C1321308	hp.json		http://purl.obolibrary.org/obo/HP_0007761		
HP:0005101	biolink:PhenotypicFeature	High-frequency hearing impairment	A type of hearing impairment affecting primarily the higher frequencies of sound (3,000 to 6,000 Hz).	SNOMEDCT_US:232326009|SNOMEDCT_US:48758008|UMLS:C0018780|MSH:D006316	hp.json	High-frequency deafness|Hearing loss, high-frequency|Progressive high-frequency hearing loss|High frequency hearing loss|Progressive high frequency hearing loss	http://purl.obolibrary.org/obo/HP_0005101		
HP:0007763	biolink:PhenotypicFeature	Retinal telangiectasia	Dilatation of small blood vessels of the retina.	UMLS:C0154835|SNOMEDCT_US:84884003	hp.json		http://purl.obolibrary.org/obo/HP_0007763		hposlim_core
HP:0005102	biolink:PhenotypicFeature	Cochlear degeneration	Deterioration or loss of the tissues of the cochlea.	UMLS:C1849095	hp.json	Progressive cochlear degeneration	http://purl.obolibrary.org/obo/HP_0005102		
HP:0007760	biolink:PhenotypicFeature	Crystalline corneal dystrophy		MSH:C535475|SNOMEDCT_US:39662004|SNOMEDCT_US:419395007|UMLS:C0271287	hp.json		http://purl.obolibrary.org/obo/HP_0007760		
HP:0030121	biolink:PhenotypicFeature	Reduced muscle fiber calpain-3	Western blot reveals reduced calpain-3 protein in the muscle biopsy tissue.	UMLS:C4022624	hp.json	Reduced muscle fibre calpain-3	http://purl.obolibrary.org/obo/HP_0030121		
HP:0032784	biolink:PhenotypicFeature	Focal aware autonomic seizure with palpitations/tachycardia/bradycardia/asystole	An autonomic seizure with palpitations / tachycardia / bradycardia / asystole characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032784		
HP:0032783	biolink:PhenotypicFeature	Focal aware autonomic seizure with piloerection	A focal autonomic seizure with piloerection (bristling of hairs due to the involuntary contraction of small muscles at the base of hair follicles) characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032783		
GO:0035637	biolink:BiologicalProcess	multicellular organismal signaling	The transfer of information occurring at the level of a multicellular organism.		hp.json	multicellular organismal signalling	http://purl.obolibrary.org/obo/GO_0035637		
PATO:0001645	biolink:NamedThing	protruding into	A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary into the surface or boundary of another entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001645		relational_slim|value_slim
HP:0030122	biolink:PhenotypicFeature	Reduced muscle fiber perlecan	Immunohistochemistry reveals reduced perlecan protein in the muscle biopsy. Perlecan is a basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) also known as heparan sulfate proteoglycan 2 (HSPG2).	UMLS:C4022623	hp.json	Reduced muscle fibre perlecan	http://purl.obolibrary.org/obo/HP_0030122		
HP:0032786	biolink:PhenotypicFeature	Migrating focal seizure	A migrating focal seizure is a seizure that involves different body parts, usually without overlap, in a consecutive manner so that the offset of a seizure in one part coincides with its onset in another, even shifting multiple times between the sides of the body. They can be associated with autonomic manifestations.		hp.json	Migrating partial seizure	http://purl.obolibrary.org/obo/HP_0032786		
HP:0030123	biolink:PhenotypicFeature	Abnormal muscle fiber lamin A/C	A deviation from the normal amount of lamin A/C in muscle tissue. The LMNA gene gives rise to at least three splicing isoforms including the two main isoforms, lamin A and lamin C. These are constitutive components of the fibrous nuclear lamina and have different roles, ranging from mechanical nuclear membrane maintenance to gene regulation.	UMLS:C4022622	hp.json	Abnormal muscle fibre lamin A/C	http://purl.obolibrary.org/obo/HP_0030123		
HP:0030124	biolink:PhenotypicFeature	Reduced muscle fiber lamin A/C	A decreased amount of lamin A/C in muscle tissue. This feature can be shown by immunohistochemistry of Western blotting of muscle tissue.	UMLS:C4022621	hp.json	Reduced muscle fibre lamin A/C	http://purl.obolibrary.org/obo/HP_0030124		
HP:0032785	biolink:PhenotypicFeature	Focal aware autonomic seizure with epigastric sensation/nausea/vomiting/other gastrointestinal phenomena	A focal autonomic seizure with epigastric sensation / nausea / vomiting / other gastrointestinal phenomena characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032785		
HP:0032780	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure with erection	A focal autonomic seizure with erection characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032780		
PATO:0001648	biolink:NamedThing	circumference	An 1-D extent quality which is equal to the length of the closed curve of a circle.		hp.json		http://purl.obolibrary.org/obo/PATO_0001648		scalar_slim|attribute_slim
PATO:0001649	biolink:NamedThing	curved lateral	A curvature quality inhering in a bearer by virtue of the bearer's being curved towards the side.		hp.json		http://purl.obolibrary.org/obo/PATO_0001649		value_slim
HP:0032782	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure with lacrimation	A focal autonomic seizure with lacrimation characterized by impaired awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032782		
PATO:0001646	biolink:NamedThing	protruding out of	A quality inhering into a bearer by virtue of the bearer's extending out above or beyond its surface or boundary and outwards in relation to the physical space occupied by another entity.		hp.json	exposed|extruding from|exits through	http://purl.obolibrary.org/obo/PATO_0001646		relational_slim|value_slim
HP:0032781	biolink:PhenotypicFeature	Focal aware autonomic seizure with urge to urinate/defecate	A focal autonomic seizure with urge to urinate / defecate characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032781		
HP:0030120	biolink:PhenotypicFeature	Absent muscle fiber calpain-3	Western blot shows complete lack of calpain-3 protein in the muscle biopsy tissue.	UMLS:C4022625	hp.json	Absent muscle fibre calpain-3	http://purl.obolibrary.org/obo/HP_0030120		
HP:0030129	biolink:PhenotypicFeature	Impaired ristocetin cofactor assay activity	Abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin to platelet-poor plasma.	UMLS:C4022619	hp.json		http://purl.obolibrary.org/obo/HP_0030129		
GO:0035630	biolink:BiologicalProcess	bone mineralization involved in bone maturation	The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state.		hp.json		http://purl.obolibrary.org/obo/GO_0035630		
HP:0032788	biolink:PhenotypicFeature	Focal impaired awareness autonomic seizure with palpitations/tachycardia/bradycardia/asystole	A focal autonomic seizure with palpitations / tachycardia / bradycardia / asystole characterized by impaired awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032788		
HP:0007777	biolink:PhenotypicFeature	Chorioretinal scar	Fibrous connective tissue resulting from incomplete healing of a wound (i.e., a scar) located in the choroid and retina or the eye.	UMLS:C0008512|SNOMEDCT_US:53854005	hp.json		http://purl.obolibrary.org/obo/HP_0007777		
HP:0030125	biolink:PhenotypicFeature	Sacralization of the fifth lumbar vertebra	A congenital anomaly, in which the transverse process of the last lumbar vertebra (L5) fuses to the sacrum on one side or both, or to ilium, or both.	UMLS:C4021052	hp.json	L5 sacralization	http://purl.obolibrary.org/obo/HP_0030125		
HP:0005114	biolink:PhenotypicFeature	obsolete Abnormalities of the peripheral arteries			hp.json		http://purl.obolibrary.org/obo/HP_0005114		
HP:0007776	biolink:PhenotypicFeature	Sparse lower eyelashes		UMLS:C1835148	hp.json	Hypotrichosis of lower eyelashes|Thin lower eyelashes|Partial absence of lower eyelashes|Scanty lower eyelashes|Sparse lower eyelashes	http://purl.obolibrary.org/obo/HP_0007776		
HP:0005115	biolink:PhenotypicFeature	Supraventricular arrhythmia	A type of arrhythmia that originates above the ventricles, whereby the electrical impulse propagates down the normal His Purkinje system similar to normal sinus rhythm.	SNOMEDCT_US:72654001|UMLS:C0428974	hp.json	Supraventricular arrhythmias	http://purl.obolibrary.org/obo/HP_0005115		
HP:0030126	biolink:PhenotypicFeature	Abnormal endometrium morphology	An anomaly of the inner mucous membrane of the uterus.	UMLS:C4022620	hp.json	Abnormality of the endometrium	http://purl.obolibrary.org/obo/HP_0030126		
HP:0032787	biolink:PhenotypicFeature	Focal impaired awareness sensory seizure	A focal sensory seizure in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032787		
HP:0030127	biolink:PhenotypicFeature	Endometriosis	The growth of endometrial tissue outside the uterus.	SNOMEDCT_US:129103003|SNOMEDCT_US:396224008|UMLS:C0014175|MSH:D004715	hp.json		http://purl.obolibrary.org/obo/HP_0030127		
HP:0005116	biolink:PhenotypicFeature	Arterial tortuosity	Abnormal tortuous (i.e., twisted) form of arteries.	UMLS:C3279191	hp.json		http://purl.obolibrary.org/obo/HP_0005116		
HP:0007779	biolink:PhenotypicFeature	Anterior segment of eye aplasia		UMLS:C1853234	hp.json		http://purl.obolibrary.org/obo/HP_0007779		
HP:0005117	biolink:PhenotypicFeature	Elevated diastolic blood pressure	Abnormal increase in diastolic blood pressure.	UMLS:C1840375	hp.json	Elevated diastolic BP	http://purl.obolibrary.org/obo/HP_0005117		
HP:0032789	biolink:PhenotypicFeature	Focal aware behavior arrest seizure	A focal behavior arrest seizure characterised by retained awareness throughout the seizure.		hp.json	Focal aware behaviour arrest seizure	http://purl.obolibrary.org/obo/HP_0032789		
HP:0007778	biolink:PhenotypicFeature	Posterior retinal neovascularization	A type of retinal neovascularization that affects the posterior pole of the retina.	UMLS:C4024803	hp.json	Neovascularization of peripheral and posterior retina|Posterior retinal neovascularisation	http://purl.obolibrary.org/obo/HP_0007778		
HP:0005110	biolink:PhenotypicFeature	Atrial fibrillation	An atrial arrhythmia characterized by disorganized atrial activity without discrete P waves on the surface EKG, but instead by an undulating baseline or more sharply circumscribed atrial deflections of varying amplitude an frequency ranging from 350 to 600 per minute.	UMLS:C0004238|SNOMEDCT_US:49436004|MSH:D001281	hp.json	Quivering upper heart chambers resulting in irregular heartbeat	http://purl.obolibrary.org/obo/HP_0005110		
HP:0007773	biolink:PhenotypicFeature	Vitreoretinopathy	Ocular abnormality characterised by premature degeneration of the vitreous and the retina that may be associated with increased risk of retinal detachment.	UMLS:C1850109	hp.json	Vitreoretinal abnormality|Vitreoretinal degeneration	http://purl.obolibrary.org/obo/HP_0007773		
HP:0007772	biolink:PhenotypicFeature	Impaired smooth pursuit	An impairment of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion.	UMLS:C1837458|UMLS:C1848530	hp.json	Abnormality of visual tracking|Abnormal visual pursuit|Impairment of visual pursuit	http://purl.obolibrary.org/obo/HP_0007772		hposlim_core
HP:0005111	biolink:PhenotypicFeature	obsolete Dilatation of the ascending aorta			hp.json		http://purl.obolibrary.org/obo/HP_0005111		
HP:0005112	biolink:PhenotypicFeature	Abdominal aortic aneurysm	An abnormal localized widening (dilatation) of the abdominal aorta.	UMLS:C4025248	hp.json	Dilatation of the abdominal aorta	http://purl.obolibrary.org/obo/HP_0005112		
HP:0005113	biolink:PhenotypicFeature	Aortic arch aneurysm	An abnormal localized widening (dilatation) of the aortic arch.	Fyler:2706|UMLS:C1851119	hp.json	Dilatation of the aortic arch|Aortic arch dilatation	http://purl.obolibrary.org/obo/HP_0005113		
HP:0007774	biolink:PhenotypicFeature	Hypoplasia of the ciliary body	Underdevelopment of the ciliary body.	UMLS:C1836890	hp.json		http://purl.obolibrary.org/obo/HP_0007774		
HP:0007770	biolink:PhenotypicFeature	Hypoplasia of the retina		UMLS:C1854685	hp.json	Retinal hypoplasia|Underdeveloped retina	http://purl.obolibrary.org/obo/HP_0007770		
HP:0005170	biolink:PhenotypicFeature	Complete heart block with broad QRS complexes	A type of third degree heart block in which the escape rhythm arises at a relatively low part of the conduction system (below the atrioventricular node), which produces a wide QRS complex.	UMLS:C1861987	hp.json		http://purl.obolibrary.org/obo/HP_0005170		
HP:0032715	biolink:PhenotypicFeature	Focal bilateral motor seizure	A type of focal motor seizure (it commences in one hemisphere) involving bilateral muscle groups rapidly at seizure onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032715		
HP:0032714	biolink:PhenotypicFeature	Focal impaired awareness bilateral motor seizure	A focal bilateral motor seizure characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032714		
HP:0032717	biolink:PhenotypicFeature	Focal impaired awareness motor seizure with dystonia	A focal motor seizure with dystonia characterized by impaired awareness at some point during the seizure.		hp.json	Focal motor impaired awareness seizure with dystonia	http://purl.obolibrary.org/obo/HP_0032717		
HP:0032716	biolink:PhenotypicFeature	Focal impaired awareness non-motor seizure	A focal non-motor seizure characterized by impaired awareness at some point during the seizure.		hp.json	Focal non-motor impaired awareness seizure	http://purl.obolibrary.org/obo/HP_0032716		
HP:0032711	biolink:PhenotypicFeature	Focal aware clonic seizure	A type of focal clonic seizure during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032711		
HP:0032710	biolink:PhenotypicFeature	Focal aware cognitive seizure with receptive dysphasia/aphasia	A focal cognitive seizure with receptive dysphasia / aphasia characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032710		
HP:0032713	biolink:PhenotypicFeature	Focal impaired awareness motor seizure with version	A focal motor seizure with version characterized by impaired awareness at some point during the seizure.		hp.json	Focal motor impaired awareness seizure with version	http://purl.obolibrary.org/obo/HP_0032713		
HP:0032712	biolink:PhenotypicFeature	Focal impaired awareness motor seizure	A type of focal motor seizure in which awareness is partially or fully impaired at some point during the seizure.		hp.json	Focal motor impaired awareness seizure	http://purl.obolibrary.org/obo/HP_0032712		
HP:0005165	biolink:PhenotypicFeature	Shortened PR interval	Reduced time for the PR interval (beginning of the P wave to the beginning of the QRS complex). In adults, normal values are 120 to 200 ms long.	UMLS:C0520878|SNOMEDCT_US:49578007	hp.json	Electrocardiographic short PR interval|Short P-R interval|Shortened PR interval on EKG	http://purl.obolibrary.org/obo/HP_0005165		
HP:0005168	biolink:PhenotypicFeature	Elevated right atrial pressure	An abnormal increase in magnitude of the pressure in the right atrium.	UMLS:C1867421	hp.json		http://purl.obolibrary.org/obo/HP_0005168		
HP:0032719	biolink:PhenotypicFeature	Focal impaired awareness motor seizure with dysarthria/anarthria	A focal motor seizure with dysarthria / anarthria characterized by impaired awareness at some point during the seizure.		hp.json	Focal motor impaired awareness seizure with dysarthria/anarthria	http://purl.obolibrary.org/obo/HP_0032719		
HP:0032718	biolink:PhenotypicFeature	Focal motor seizure with dystonia	A focal motor seizure in which the initial semiological manifestation is the sustained contraction of both agonist and antagonist muscles producing athetoid or twisting movements, which produces abnormal postures.		hp.json		http://purl.obolibrary.org/obo/HP_0032718		
HP:0005162	biolink:PhenotypicFeature	Abnormal left ventricular function	Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole.	SNOMEDCT_US:85232009|UMLS:C0023212|MSH:D006333|UMLS:C0553982|SNOMEDCT_US:275514001	hp.json	Left ventricular failure|Impaired left ventricular function|Left ventricular dysfunction|Left-sided heart failure|Left ventricular impairment	http://purl.obolibrary.org/obo/HP_0005162		
HP:0005164	biolink:PhenotypicFeature	Dysplastic pulmonary valve	A congenital malformation of the pulmonary valve characterized by leaflet deformation.	UMLS:C1866206	hp.json	Pulmonary valve dysplasia|Dysplasia of pulmonary valve	http://purl.obolibrary.org/obo/HP_0005164		
HP:0005180	biolink:PhenotypicFeature	Tricuspid regurgitation	Failure of the tricuspid valve to close sufficiently upon contraction of the right ventricle, causing blood to regurgitate (flow backward) into the right atrium.	MSH:D014262|UMLS:C0040961|SNOMEDCT_US:111287006|Fyler:1161	hp.json	Tricuspid insufficiency|Tricuspid valve regurgitation	http://purl.obolibrary.org/obo/HP_0005180		
HP:0005181	biolink:PhenotypicFeature	Premature coronary artery atherosclerosis	Reduction of the diameter of the coronary arteries as the result of an accumulation of atheromatous plaques within the walls of the coronary arteries before age of 45.	UMLS:C1867743	hp.json	Premature coronary artery disease	http://purl.obolibrary.org/obo/HP_0005181		
HP:0005182	biolink:PhenotypicFeature	Bicuspid pulmonary valve	The presence of a bicuspid pulmonary valve.	UMLS:C0344987|Fyler:1601|SNOMEDCT_US:253599005	hp.json		http://purl.obolibrary.org/obo/HP_0005182		
GO:0008017	biolink:MolecularActivity	microtubule binding	Binding to a microtubule, a filament composed of tubulin monomers.	Reactome:R-HSA-9614343	hp.json	microtubule/chromatin interaction|microtubule severing activity	http://purl.obolibrary.org/obo/GO_0008017		
GO:0008016	biolink:BiologicalProcess	regulation of heart contraction	Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.		hp.json	regulation of cardiac contraction	http://purl.obolibrary.org/obo/GO_0008016		
GO:0008015	biolink:BiologicalProcess	blood circulation	The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.		hp.json	hemolymph circulation	http://purl.obolibrary.org/obo/GO_0008015		goslim_pir
HP:0032720	biolink:PhenotypicFeature	Focal motor seizure with dysarthria/anarthria	A type of focal motor seizure characterized by difficulty with articulation of speech, due to impaired coordination of muscles involved in speech sound production as the initial semiological manifestation. Receptive and expressive language functions are intact, however speech is poorly articulated and is less intelligible.		hp.json		http://purl.obolibrary.org/obo/HP_0032720		
HP:0032726	biolink:PhenotypicFeature	Focal impaired awareness hyperkinetic seizure	A focal hyperkinetic seizure in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032726		
HP:0032725	biolink:PhenotypicFeature	Focal impaired awareness clonic seizure	A type of focal clonic seizure during which awareness is partially or fully impaired at some point in the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032725		
HP:0032728	biolink:PhenotypicFeature	Focal impaired awareness atonic seizure	A focal atonic seizure in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032728		
HP:0032727	biolink:PhenotypicFeature	Focal emotional seizure with agitation	Focal emotional seizure with agitation is characterized by the presence of psychomotor agitation as an expressed or observed emotion, at the outset of the seizure. Because of the unpleasant nature of these seizures, patients may also have anticipatory anxiety about having seizures.		hp.json		http://purl.obolibrary.org/obo/HP_0032727		
HP:0032722	biolink:PhenotypicFeature	Focal aware tonic seizure	A type of focal tonic seizure during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032722		
HP:0032721	biolink:PhenotypicFeature	Focal motor seizure with paresis/paralysis	A focal motor seizure characterized by weakness or complete paralysis of a muscle or group of muscles as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032721		
HP:0032724	biolink:PhenotypicFeature	Focal impaired awareness tonic seizure	A focal tonic seizure in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032724		
HP:0032723	biolink:PhenotypicFeature	Focal aware motor seizure with dystonia	A focal motor seizure with dystonia characterized by retained awareness throughout the seizure.		hp.json	Focal motor aware seizure with dystonia	http://purl.obolibrary.org/obo/HP_0032723		
HP:0005176	biolink:PhenotypicFeature	Dysplastic aortic valve	A congenital malformation of the aortic valve characterized by leaflet deformation.	UMLS:C1866207	hp.json		http://purl.obolibrary.org/obo/HP_0005176		
HP:0005177	biolink:PhenotypicFeature	Premature arteriosclerosis	Arteriosclerosis occurring at an age that is younger than usual.	UMLS:C1848486|UMLS:C4280503	hp.json	Premature hardening of arteries	http://purl.obolibrary.org/obo/HP_0005177		
HP:0005178	biolink:PhenotypicFeature	Complete heart block with narrow QRS complexes	A type of third degree heart block in which the escape rhythm arises at the atrioventricular node, which produces a narrow QRS complex.	UMLS:C1841661	hp.json		http://purl.obolibrary.org/obo/HP_0005178		
HP:0005172	biolink:PhenotypicFeature	Left posterior fascicular block	Conduction block in the posterior division of the left bundle branch of the bundle of His.	SNOMEDCT_US:62026008|UMLS:C0264913	hp.json	Left posterior hemiblock	http://purl.obolibrary.org/obo/HP_0005172		
HP:0005173	biolink:PhenotypicFeature	obsolete Calcific aortic valve stenosis			hp.json		http://purl.obolibrary.org/obo/HP_0005173		
HP:0032729	biolink:PhenotypicFeature	Focal emotional seizure with pleasure	Focal emotional seizure with pleasure is characterized by the presence of a positive emotional experience with pleasure, bliss, joy, enhanced personal well-being, heightened self-awareness or ecstasy.		hp.json		http://purl.obolibrary.org/obo/HP_0032729		
CHEBI:58048	biolink:ChemicalSubstance	L-asparagine zwitterion	Zwitterionic form of L-asparagine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3.	MetaCyc:ASN	hp.json	(2S)-4-amino-2-azaniumyl-4-oxobutanoate|(2S)-2-ammonio-3-carbamoylpropanoate|L-asparagine|(2S)-4-amino-2-ammonio-4-oxobutanoate|(2S)-2-azaniumyl-3-carbamoylpropanoate	http://purl.obolibrary.org/obo/CHEBI_58048		3_STAR
HP:0005174	biolink:PhenotypicFeature	Membranous subvalvular aortic stenosis	Subvalvular stenosis is caused by a diaphragm-like membrane. The stenosis is clinically manifested like any other form of aortic stenosis but is often associated with some aortic insufficiency.	UMLS:C1848978	hp.json		http://purl.obolibrary.org/obo/HP_0005174		
HP:0032731	biolink:PhenotypicFeature	Focal aware hyperkinetic seizure	A type of focal hypermotor seizure during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032731		
HP:0032730	biolink:PhenotypicFeature	Focal impaired awareness myoclonic seizure	A focal myoclonic seizure in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032730		
HP:0032737	biolink:PhenotypicFeature	Focal emotional seizure with paranoia	Focal emotional seizure with paranoia is characterized by the presence of paranoia as an expressed or observed emotion at the outset of the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032737		
HP:0032736	biolink:PhenotypicFeature	Focal emotional seizure with anger	Focal emotional seizure with anger is characterized by the presence of anger, as an expressed or observed emotion, at the outset of the seizure. It may be accompanied by aggressive behaviour.		hp.json		http://purl.obolibrary.org/obo/HP_0032736		
HP:0032739	biolink:PhenotypicFeature	Focal emotional seizure with fear/anxiety/panic	Focal emotional seizure with anxiety is characterized by the presence of anxiety, fear or panic as an expressed or observed emotion, at the outset of the seizure. Because of the unpleasant nature of these seizures, patients may also have anticipatory anxiety about having seizures.		hp.json		http://purl.obolibrary.org/obo/HP_0032739		
HP:0032738	biolink:PhenotypicFeature	Focal aware emotional seizure with fear/anxiety/panic	Focal emotional seizure with anxiety, fear or panic as an expressed or observed emotion at the outset of the seizure, in which awareness is retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032738		
HP:0032733	biolink:PhenotypicFeature	Focal aware motor seizure with dysarthria/anarthria	A focal motor seizure with dysarthria / anarthria characterized by retained awareness throughout the seizure.		hp.json	Focal motor aware seizure with dysarthria/anarthria	http://purl.obolibrary.org/obo/HP_0032733		
HP:0005147	biolink:PhenotypicFeature	Bidirectional ventricular ectopy		UMLS:C1969410	hp.json		http://purl.obolibrary.org/obo/HP_0005147		
HP:0005148	biolink:PhenotypicFeature	Pulmonary valve defects	Any defect in the valve connecting the heart and the pulmonary artery.	UMLS:C1860165	hp.json		http://purl.obolibrary.org/obo/HP_0005148		
HP:0032732	biolink:PhenotypicFeature	Focal aware motor seizure with paresis/paralysis	A focal motor seizure with paresis / paralysis characterized by retained awareness throughout the seizure.		hp.json	Focal motor aware seizure with paresis/paralysis	http://purl.obolibrary.org/obo/HP_0032732		
HP:0032735	biolink:PhenotypicFeature	Focal aware emotional seizure with anger	Focal emotional seizure with anger in which awareness is retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032735		
HP:0032734	biolink:PhenotypicFeature	Focal aware emotional seizure	A focal emotional seizure during which awareness is retained throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032734		
HP:0005143	biolink:PhenotypicFeature	Anomalous origin of right pulmonary artery from ascending aorta	The right pulmonary artery originates from the ascending aorta in the presence of a pulmonary valve and main pulmonary artery.	SNOMEDCT_US:253634009|UMLS:C0345037	hp.json		http://purl.obolibrary.org/obo/HP_0005143		
HP:0005144	biolink:PhenotypicFeature	Ventricular septal hypertrophy	The dividing wall between left and right sides of the heart, thickens and bulges into the left ventricle.	UMLS:C1845019	hp.json	Thickened interventricular septum	http://purl.obolibrary.org/obo/HP_0005144		
HP:0005145	biolink:PhenotypicFeature	Coronary artery stenosis	Abnormal narrowing of the coronary artery.	UMLS:C0242231|MSH:D023921|SNOMEDCT_US:233970002	hp.json	Narrowing of coronary artery	http://purl.obolibrary.org/obo/HP_0005145		
HP:0005146	biolink:PhenotypicFeature	Cardiac valve calcification	Abnormal calcification of a cardiac valve.	UMLS:C1856483	hp.json	Calcifications of the cardiac valves	http://purl.obolibrary.org/obo/HP_0005146		
HP:0005141	biolink:PhenotypicFeature	obsolete Episodes of ventricular tachycardia			hp.json		http://purl.obolibrary.org/obo/HP_0005141		
PATO:0001608	biolink:NamedThing	patchy	A spatial pattern inhering in a bearer by virtue of the bearer's being marked by, consisting of, or diversified with patches.		hp.json		http://purl.obolibrary.org/obo/PATO_0001608		mpath_slim|value_slim
PATO:0001609	biolink:NamedThing	sparse	A spatial pattern inhering in a bearer by virtue of the bearer's being scattered; spread irregularly, and at a distance from each other.		hp.json		http://purl.obolibrary.org/obo/PATO_0001609		mpath_slim|value_slim
HP:0005160	biolink:PhenotypicFeature	Total anomalous pulmonary venous return	Total anomalous pulmonary venous return refers to a congenital malformation in which all four pulmonary veins do not connect normally to the left atrium, but instead drain abnormally to the right atrium.	SNOMEDCT_US:39905002|MSH:D012587|Fyler:0900|SNOMEDCT_US:111323005|UMLS:C0036400|Fyler:900	hp.json	Total anomalous pulmonary venous connection|Total anomalous pulmonary venous drainage	http://purl.obolibrary.org/obo/HP_0005160		
PATO:0001600	biolink:NamedThing	posteriorly rotated	A rotation quality inhering in a bearer by virtue of being rotated towards the rear of organism.		hp.json		http://purl.obolibrary.org/obo/PATO_0001600		value_slim|mpath_slim
HP:0032740	biolink:PhenotypicFeature	Focal aware autonomic seizure	A focal aware autonomic seizure has an initial manifestation pertaining to autonomic nervous system function, which may be objective (for example, pupillary dilation) or subjective (for example, nausea). As a type of focal aware seizure, awareness is retained throughout.		hp.json	Localized autonomic seizures without altered responsiveness|Focal autonomic seizures without altered responsiveness|Localised autonomic seizures without altered responsiveness|Partial autonomic seizures without altered responsiveness	http://purl.obolibrary.org/obo/HP_0032740		
HP:0032742	biolink:PhenotypicFeature	Focal aware emotional seizure with pleasure	Focal emotional seizure with pleasure in which awareness is retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032742		
HP:0032741	biolink:PhenotypicFeature	Focal aware emotional seizure with paranoia	Focal emotional seizure with paranoia in which awareness is retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032741		
PATO:0001602	biolink:NamedThing	distended	A size quality inhering in a bearer by virtue of the bearer's being abnormally expanded or increased in size.		hp.json	expanded	http://purl.obolibrary.org/obo/PATO_0001602		value_slim|mpath_slim
CHEBI:61660	biolink:ChemicalSubstance	organic sulfamate oxoanion	An anion resulting from the removal of a proton from an organic sulfamic acid group.		hp.json	an organic sulfamic acid anion|organic sulfamic acid anions	http://purl.obolibrary.org/obo/CHEBI_61660		3_STAR
HP:0032748	biolink:PhenotypicFeature	Focal impaired awareness emotional seizure with anger	Focal emotional seizure with anger in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032748		
HP:0032747	biolink:PhenotypicFeature	Focal impaired awareness emotional seizure with pleasure	Focal emotional seizure with pleasure in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032747		
HP:0032749	biolink:PhenotypicFeature	Focal impaired awareness emotional seizure with paranoia	Focal emotional seizure with paranoia in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032749		
HP:0032744	biolink:PhenotypicFeature	Focal aware emotional seizure with agitation	Focal emotional seizure with agitation in which awareness is retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032744		
HP:0032743	biolink:PhenotypicFeature	Focal aware emotional seizure with crying	Focal emotional seizure with crying (dacrystic)in which awareness is retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032743		
HP:0032746	biolink:PhenotypicFeature	Focal impaired awareness emotional seizure	A focal emotional seizure in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032746		
HP:0032745	biolink:PhenotypicFeature	Focal aware emotional seizure with laughing	Focal emotional seizure with laughing in which awareness is retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032745		
HP:0005155	biolink:PhenotypicFeature	Ventricular escape rhythm	A ventircular escape rhythm occurs whenever higher-lever pacemakers in AV junction or sinus node fail to control ventricular activation. Escape rate is usually 20-40 bpm, often associated with broad QRS complexes (at least 120 ms).	SNOMEDCT_US:81898007|UMLS:C0232216	hp.json	Idioventricular escape rhythm	http://purl.obolibrary.org/obo/HP_0005155		
HP:0005156	biolink:PhenotypicFeature	Hypoplastic left atrium	Underdeveloped, small left heart atrium	UMLS:C1970625|Fyler:3040	hp.json	Left atrium hypoplasia|Underdeveloped left heart atrium	http://purl.obolibrary.org/obo/HP_0005156		
HP:0005157	biolink:PhenotypicFeature	Concentric hypertrophic cardiomyopathy	Hypertrophic cardiomyopathy with an symmetrical and concentric pattern of hypertrophy.	UMLS:C0238044	hp.json	Symmetric, concentric, hypertrophic cardiomyopathy	http://purl.obolibrary.org/obo/HP_0005157		
HP:0005150	biolink:PhenotypicFeature	Abnormal atrioventricular conduction	An impairment of the electrical continuity between the atria and ventricles.	UMLS:C4025244	hp.json		http://purl.obolibrary.org/obo/HP_0005150		
HP:0005151	biolink:PhenotypicFeature	Preductal coarctation of the aorta	Narrowing or constriction of the aorta localized proximal to the ductus arteriosus, i.e., to the preductal region of aortic arch.	UMLS:C0265878|SNOMEDCT_US:13867009	hp.json	Proximal aortic coarctation	http://purl.obolibrary.org/obo/HP_0005151		
HP:0005152	biolink:PhenotypicFeature	Histiocytoid cardiomyopathy	A type of cardiomyopathy characterized pathologically by hamartomatous lesions of cardiac Purkinje cells.	UMLS:C1708371|MSH:C535584	hp.json	Focal lipid cardiomyopathy|Myocardial or conduction system hamartoma|Infantile xanthomatous cardiomyopathy|Isolated cardiac lipidosis|Foamy myocardial transformation|Infantile cardiomyopathy with histiocytoid changes|Arachnocytosis of the myocardium|Oncocytic cardiomyopathy	http://purl.obolibrary.org/obo/HP_0005152		
UBERON:2001053	biolink:AnatomicalEntity	future internal carotid artery		ZFA:0001053|EFO:0003612|TAO:0001053	hp.json	primitive internal carotid artery|PICA	http://purl.obolibrary.org/obo/UBERON_2001053		
GO:0060591	biolink:BiologicalProcess	chondroblast differentiation	The process in which a mesenchymal cell, acquires specialized structural and/or functional features of a chondroblast. Differentiation includes the processes involved in commitment of a cell to a chondroblast fate. A chondroblast is a precursor cell to chondrocytes.		hp.json	chondrocyte progenitor cell differentiation	http://purl.obolibrary.org/obo/GO_0060591		
HP:0007708	biolink:PhenotypicFeature	Absent inner eyelashes		UMLS:C4024812	hp.json	Absent inner eyelashes	http://purl.obolibrary.org/obo/HP_0007708		
HP:0007707	biolink:PhenotypicFeature	Congenital aphakia	Absence of the crystalline lens of the eye as a result of a developmental defect.	MSH:C537786|UMLS:C1853230	hp.json	Lens agenesis	http://purl.obolibrary.org/obo/HP_0007707		
HP:0007709	biolink:PhenotypicFeature	Band-shaped corneal dystrophy	A type of genetically determined disease of the cornea with corneal lesions with a band-like shape.	SNOMEDCT_US:35055000|UMLS:C0155120|MSH:C562399	hp.json		http://purl.obolibrary.org/obo/HP_0007709		
HP:0007704	biolink:PhenotypicFeature	Paroxysmal involuntary eye movements	Sudden-onset episode of abnormal, involuntary eye movements.	UMLS:C1847515	hp.json	Abnormal eye movements, paroxysmal	http://purl.obolibrary.org/obo/HP_0007704		
HP:0007703	biolink:PhenotypicFeature	Abnormality of retinal pigmentation		UMLS:C1862475|SNOMEDCT_US:421689001|UMLS:C1720508	hp.json	Abnormality of RPE|Abnormality of the retinal pigment epithelium|Abnormal retinal pigmentation|Retinal pigmentary anomaly|Abnormality of retinal pigment epithelium	http://purl.obolibrary.org/obo/HP_0007703		
HP:0007705	biolink:PhenotypicFeature	Corneal degeneration		UMLS:C0155118|SNOMEDCT_US:111521006	hp.json		http://purl.obolibrary.org/obo/HP_0007705		
HP:0007700	biolink:PhenotypicFeature	Ocular anterior segment dysgenesis	Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin.	UMLS:C0266525|SNOMEDCT_US:65075004	hp.json	Anterior chamber cleavage disorder|Anterior segment developmental abnormality|Anterior chamber mesodermal anomalies|Anterior segment mesencyhmal dysgenesis|Anterior chamber malformation|Anterior segment dysgenesis|Anterior segment ocular dysgenesis|Anterior chamber cleavage defect	http://purl.obolibrary.org/obo/HP_0007700		
HP:0007702	biolink:PhenotypicFeature	obsolete Pigmentary retinal deposits			hp.json		http://purl.obolibrary.org/obo/HP_0007702		
GO:0072577	biolink:BiologicalProcess	endothelial cell apoptotic process	Any apoptotic process in an endothelial cell. An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal.		hp.json	apoptosis of endothelial cells|programmed cell death of endothelial cells by apoptosis|killing of endothelial cells|endothelial cell apoptosis|programmed cell death, endothelial cells|endothelial cell programmed cell death by apoptosis	http://purl.obolibrary.org/obo/GO_0072577		
GO:0060581	biolink:BiologicalProcess	cell fate commitment involved in pattern specification	The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells within a field of cells that will exhibit a certain pattern of differentiation. Positional information is established through protein signals that emanate from a localized source within a developmental field resulting in specification of a cell type. Those signals are then interpreted in a cell-autonomous manner resulting in the determination of the cell type.		hp.json		http://purl.obolibrary.org/obo/GO_0060581		
HP:0007715	biolink:PhenotypicFeature	Weak extraocular muscles		UMLS:C1859436	hp.json		http://purl.obolibrary.org/obo/HP_0007715		
GO:0060586	biolink:BiologicalProcess	multicellular organismal iron ion homeostasis	Any process involved in the maintenance of the distribution of iron stores within tissues and organs of a multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0060586		
HP:0007717	biolink:PhenotypicFeature	Chronic irritative conjunctivitis	A chronic irritative conjunctivitis, which commonly presents with general irritation and redness of the eyes, with a burning, dry, or foreign-body sensation of the eyes.	UMLS:C4024810	hp.json		http://purl.obolibrary.org/obo/HP_0007717		
HP:0007716	biolink:PhenotypicFeature	Uveal melanoma	A malignant melanoma originating within the eye. The tumor originates from the melanocytes in the uvea (which comprises the iris, ciliary body, and choroid).	MSH:C536494|UMLS:C0220633|NCIT:C3224	hp.json	Intraocular melanoma	http://purl.obolibrary.org/obo/HP_0007716		
HP:0007710	biolink:PhenotypicFeature	Peripheral vitreous opacities		UMLS:C4024811	hp.json		http://purl.obolibrary.org/obo/HP_0007710		
HP:0007713	biolink:PhenotypicFeature	obsolete Juvenile zonular cataracts			hp.json		http://purl.obolibrary.org/obo/HP_0007713		
HP:0007712	biolink:PhenotypicFeature	obsolete Choroidal dystrophy			hp.json		http://purl.obolibrary.org/obo/HP_0007712		
GO:0072594	biolink:BiologicalProcess	establishment of protein localization to organelle	The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle.		hp.json	establishment of protein localisation to organelle	http://purl.obolibrary.org/obo/GO_0072594		
GO:0072593	biolink:BiologicalProcess	reactive oxygen species metabolic process	The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.		hp.json	reactive oxygen species metabolism|ROS metabolic process	http://purl.obolibrary.org/obo/GO_0072593		
GO:0072592	biolink:BiologicalProcess	oxygen metabolic process	The chemical reactions and pathways involving diatomic oxygen (O2).		hp.json	diatomic oxygen metabolic process|oxygen metabolism	http://purl.obolibrary.org/obo/GO_0072592		
UBERON:2001073	biolink:AnatomicalEntity	axial vasculature		ZFA:0001073	hp.json		http://purl.obolibrary.org/obo/UBERON_2001073		
GO:1901464	biolink:BiologicalProcess	negative regulation of tetrapyrrole biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole biosynthetic process.		hp.json	down regulation of tetrapyrrole anabolism|downregulation of tetrapyrrole synthesis|inhibition of tetrapyrrole biosynthesis|down-regulation of tetrapyrrole anabolism|downregulation of tetrapyrrole formation|negative regulation of tetrapyrrole anabolism|down regulation of tetrapyrrole synthesis|negative regulation of tetrapyrrole biosynthesis|down-regulation of tetrapyrrole biosynthetic process|down-regulation of tetrapyrrole biosynthesis|down-regulation of tetrapyrrole synthesis|down regulation of tetrapyrrole formation|inhibition of tetrapyrrole anabolism|negative regulation of tetrapyrrole synthesis|down regulation of tetrapyrrole biosynthetic process|down regulation of tetrapyrrole biosynthesis|down-regulation of tetrapyrrole formation|negative regulation of tetrapyrrole formation|inhibition of tetrapyrrole synthesis|downregulation of tetrapyrrole biosynthetic process|inhibition of tetrapyrrole biosynthetic process|downregulation of tetrapyrrole anabolism|downregulation of tetrapyrrole biosynthesis|inhibition of tetrapyrrole formation	http://purl.obolibrary.org/obo/GO_1901464		
GO:1901465	biolink:BiologicalProcess	positive regulation of tetrapyrrole biosynthetic process	Any process that activates or increases the frequency, rate or extent of tetrapyrrole biosynthetic process.		hp.json	up regulation of tetrapyrrole biosynthesis|up regulation of tetrapyrrole biosynthetic process|up-regulation of tetrapyrrole synthesis|up regulation of tetrapyrrole formation|activation of tetrapyrrole biosynthetic process|positive regulation of tetrapyrrole biosynthesis|activation of tetrapyrrole anabolism|upregulation of tetrapyrrole anabolism|up-regulation of tetrapyrrole formation|upregulation of tetrapyrrole biosynthetic process|upregulation of tetrapyrrole biosynthesis|activation of tetrapyrrole biosynthesis|activation of tetrapyrrole synthesis|upregulation of tetrapyrrole synthesis|positive regulation of tetrapyrrole anabolism|up regulation of tetrapyrrole anabolism|activation of tetrapyrrole formation|upregulation of tetrapyrrole formation|positive regulation of tetrapyrrole synthesis|up-regulation of tetrapyrrole biosynthetic process|up-regulation of tetrapyrrole biosynthesis|up-regulation of tetrapyrrole anabolism|up regulation of tetrapyrrole synthesis|positive regulation of tetrapyrrole formation	http://purl.obolibrary.org/obo/GO_1901465		
GO:1901463	biolink:BiologicalProcess	regulation of tetrapyrrole biosynthetic process	Any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process.		hp.json	regulation of tetrapyrrole synthesis|regulation of tetrapyrrole formation|regulation of tetrapyrrole biosynthesis|regulation of tetrapyrrole anabolism	http://purl.obolibrary.org/obo/GO_1901463		
HP:0032704	biolink:PhenotypicFeature	Focal aware cognitive seizure with illusion	A focal cognitive seizure with illusion characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032704		
HP:0032703	biolink:PhenotypicFeature	obsolete Hallucinatory aura			hp.json		http://purl.obolibrary.org/obo/HP_0032703		
HP:0032706	biolink:PhenotypicFeature	Focal aware cognitive seizure with left-right confusion	A focal cognitive seizure with left-right confusion characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032706		
HP:0032705	biolink:PhenotypicFeature	Focal aware cognitive seizure with forced thinking	A focal cognitive seizure with forced thinking characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032705		
HP:0032700	biolink:PhenotypicFeature	Focal cognitive seizure with left-right confusion	A focal cognitive seizure characterized by left-right confusion as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032700		
HP:0032702	biolink:PhenotypicFeature	Focal cognitive seizure with expressive dysphasia/aphasia	A focal cognitive seizure characterized by expressive dysphasia / aphasia as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032702		
HP:0032701	biolink:PhenotypicFeature	Focal cognitive seizure with anomia	A focal cognitive seizure characterized by anomia as the initial semiological manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032701		
HP:0032708	biolink:PhenotypicFeature	Focal aware cognitive seizure with anomia	A focal cognitive seizure with anomia characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032708		
GO:0035592	biolink:BiologicalProcess	establishment of protein localization to extracellular region	The directed movement of a protein to a specific location within the extracellular region.		hp.json	establishment of protein localisation in extracellular region|establishment of protein localization in extracellular region	http://purl.obolibrary.org/obo/GO_0035592		
HP:0032707	biolink:PhenotypicFeature	Focal aware cognitive seizure with dyslexia/alexia	A focal cognitive seizure with dyslexia / alexia characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032707		
HP:0032709	biolink:PhenotypicFeature	Focal aware cognitive seizure with dysgraphia/agraphia	A focal cognitive seizure with dysgraphia / agraphia characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032709		
HP:0007748	biolink:PhenotypicFeature	obsolete Irido-fundal coloboma			hp.json		http://purl.obolibrary.org/obo/HP_0007748		
HP:0007747	biolink:PhenotypicFeature	Monocular horizontal nystagmus		UMLS:C4024807	hp.json		http://purl.obolibrary.org/obo/HP_0007747		
GO:1901494	biolink:BiologicalProcess	regulation of cysteine metabolic process	Any process that modulates the frequency, rate or extent of cysteine metabolic process.		hp.json	regulation of cysteine metabolism	http://purl.obolibrary.org/obo/GO_1901494		
HP:0007744	biolink:PhenotypicFeature	obsolete Iridoretinal coloboma			hp.json		http://purl.obolibrary.org/obo/HP_0007744		
HP:0007740	biolink:PhenotypicFeature	Long eyelashes in irregular rows		UMLS:C1850640	hp.json	Long eyelashes in irregular rows	http://purl.obolibrary.org/obo/HP_0007740		
GO:1901495	biolink:BiologicalProcess	negative regulation of cysteine metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of cysteine metabolic process.		hp.json	downregulation of cysteine metabolic process|negative regulation of cysteine metabolism|down-regulation of cysteine metabolism|down regulation of cysteine metabolic process|down regulation of cysteine metabolism|inhibition of cysteine metabolic process|down-regulation of cysteine metabolic process|inhibition of cysteine metabolism|downregulation of cysteine metabolism	http://purl.obolibrary.org/obo/GO_1901495		
GO:1901496	biolink:BiologicalProcess	positive regulation of cysteine metabolic process	Any process that activates or increases the frequency, rate or extent of cysteine metabolic process.		hp.json	up regulation of cysteine metabolism|positive regulation of cysteine metabolism|up regulation of cysteine metabolic process|activation of cysteine metabolism|up-regulation of cysteine metabolic process|upregulation of cysteine metabolism|activation of cysteine metabolic process|upregulation of cysteine metabolic process|up-regulation of cysteine metabolism	http://purl.obolibrary.org/obo/GO_1901496		
HP:0007759	biolink:PhenotypicFeature	Opacification of the corneal stroma	Reduced transparency of the stroma of cornea.	UMLS:C1856661|UMLS:C0423250|SNOMEDCT_US:246957002	hp.json	Cloudy cornea|Cloudy corneas|Corneal stromal opacity	http://purl.obolibrary.org/obo/HP_0007759		
HP:0007758	biolink:PhenotypicFeature	obsolete Congenital visual impairment			hp.json		http://purl.obolibrary.org/obo/HP_0007758		
HP:0007755	biolink:PhenotypicFeature	Juvenile epithelial corneal dystrophy		MSH:D053559|UMLS:C0339277|SNOMEDCT_US:1674008	hp.json		http://purl.obolibrary.org/obo/HP_0007755		
GO:0035577	biolink:CellularComponent	azurophil granule membrane	The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.		hp.json	primary granule membrane	http://purl.obolibrary.org/obo/GO_0035577		
HP:0007754	biolink:PhenotypicFeature	Macular dystrophy	Macular dystrophy is a nonspecific term for premature retinal cell aging and cell death, generally confied to the macula in which no clear extrinsic cause is evident.	UMLS:C0730292	hp.json		http://purl.obolibrary.org/obo/HP_0007754		hposlim_core
HP:0007757	biolink:PhenotypicFeature	obsolete Hypoplasia of choroid			hp.json		http://purl.obolibrary.org/obo/HP_0007757		
HP:0007756	biolink:PhenotypicFeature	obsolete Slitlike anterior chamber angles in children			hp.json		http://purl.obolibrary.org/obo/HP_0007756		
HP:0007750	biolink:PhenotypicFeature	Hypoplasia of the fovea	Underdevelopment of the fovea centralis.	UMLS:C4072863|UMLS:C2673946	hp.json	Foveal hypoplasia	http://purl.obolibrary.org/obo/HP_0007750		
PR:P18181	biolink:Protein	CD48 antigen (mouse)	A CD48 molecule that is encoded in the genome of mouse.	UniProtKB:P18181	hp.json	CD48 (mouse)|Cd48|mCD48|SLAMF2 (mouse)|BCM1 surface antigen (mouse)|Bcm-1|MRC OX-45 surface antigen (mouse)|HM48-1 (mouse)|signaling lymphocytic activation molecule 2 (mouse)|SLAM family member 2 (mouse)|BLAST-1 (mouse)|sgp-60 (mouse)	http://purl.obolibrary.org/obo/PR_P18181		
GO:0035562	biolink:BiologicalProcess	negative regulation of chromatin binding	Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.		hp.json		http://purl.obolibrary.org/obo/GO_0035562		
GO:0035563	biolink:BiologicalProcess	positive regulation of chromatin binding	Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.		hp.json		http://purl.obolibrary.org/obo/GO_0035563		
HP:0007728	biolink:PhenotypicFeature	Congenital miosis	Abnormal (non-physiological) constriction of the pupil of congenital onset.	MSH:C537550|SNOMEDCT_US:400962005|UMLS:C1303009	hp.json		http://purl.obolibrary.org/obo/HP_0007728		
HP:0007727	biolink:PhenotypicFeature	Opacification of the corneal epithelium	Lack of transparency of the corneal epithelium.	UMLS:C1849198	hp.json	Superficial corneal opacities	http://purl.obolibrary.org/obo/HP_0007727		
HP:0007722	biolink:PhenotypicFeature	Retinal pigment epithelial atrophy	Atrophy (loss or wasting) of the retinal pigment epithelium observed on fundoscopy or fundus imaging.	UMLS:C1840457	hp.json		http://purl.obolibrary.org/obo/HP_0007722		
HP:0007721	biolink:PhenotypicFeature	Saccular conjunctival dilatations	Presence of multiple dilatations (sac-like outpouchings) in the blood vessels of the conjunctiva.	UMLS:C3277464	hp.json	Saccular conjunctival aneurysms	http://purl.obolibrary.org/obo/HP_0007721		
HP:0007720	biolink:PhenotypicFeature	Flat cornea	Cornea plana is an abnormally flat shape of the cornea such that the normal protrusion of the cornea from the sclera is missing. The reduced corneal curvature can lead to hyperopia, and a hazy corneal limbus and arcus lipoides may develop at an early age.	UMLS:C0344529|SNOMEDCT_US:204145006	hp.json	Cornea plana	http://purl.obolibrary.org/obo/HP_0007720		
GO:0035561	biolink:BiologicalProcess	regulation of chromatin binding	Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.		hp.json		http://purl.obolibrary.org/obo/GO_0035561		
HP:0007737	biolink:PhenotypicFeature	Bone spicule pigmentation of the retina	Pigment migration into the retina in a bone-spicule configuration (resembling the nucleated cells within the lacuna of bone).	UMLS:C1836926	hp.json	Retinal pigmented bone spicules|Retinal bone corpuscle pigmentation|Bone corpuscle fundus pigmentation|Fundus with peripheral bony spicules|Retinal 'bone corpuscle' pigmentation	http://purl.obolibrary.org/obo/HP_0007737		
HP:0007736	biolink:PhenotypicFeature	obsolete Pericentral retinal dystrophy			hp.json		http://purl.obolibrary.org/obo/HP_0007736		
HP:0007739	biolink:PhenotypicFeature	obsolete Mildly reduced visual acuity			hp.json		http://purl.obolibrary.org/obo/HP_0007739		
HP:0007738	biolink:PhenotypicFeature	Uncontrolled eye movements		UMLS:C1854686	hp.json		http://purl.obolibrary.org/obo/HP_0007738		
HP:0007733	biolink:PhenotypicFeature	Laterally curved eyebrow		UMLS:C1846266	hp.json		http://purl.obolibrary.org/obo/HP_0007733		
GO:0035556	biolink:BiologicalProcess	intracellular signal transduction	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.		hp.json	intracellular signaling cascade|intracellular protein kinase cascade|intracellular signaling pathway|signal transduction via intracellular signaling cascade|protein kinase cascade|intracellular signaling chain|intracellular signal transduction pathway|signal transmission via intracellular cascade	http://purl.obolibrary.org/obo/GO_0035556		goslim_drosophila
HP:0007732	biolink:PhenotypicFeature	Lacrimal gland hypoplasia	Underdevelopment of the lacrimal gland.	UMLS:C1863200	hp.json	Underdeveloped tear gland|Hypoplastic lacrimal gland	http://purl.obolibrary.org/obo/HP_0007732		
HP:0007734	biolink:PhenotypicFeature	Enlarged lacrimal glands	Abnormally big lacrimal glands.	UMLS:C1867030	hp.json	Enlarged tear gland	http://purl.obolibrary.org/obo/HP_0007734		
HP:0007731	biolink:PhenotypicFeature	Chorioretinal dysplasia	Abnormal development of the choroid and retina.	UMLS:C4024809	hp.json		http://purl.obolibrary.org/obo/HP_0007731		
HP:0007730	biolink:PhenotypicFeature	Iris hypopigmentation	An abnormal reduction in the amount of pigmentation of the iris.	UMLS:C0154920|SNOMEDCT_US:70397008|SNOMEDCT_US:247032003	hp.json	Light eye color|Light eye colour|Reduced iris pigmentation	http://purl.obolibrary.org/obo/HP_0007730		
UBERON:0013491	biolink:AnatomicalEntity	cervical fascia	Any fascia tissue that is part of the neck region.	FMA:76866	hp.json	fascia of neck	http://purl.obolibrary.org/obo/UBERON_0013491		
UBERON:0013493	biolink:AnatomicalEntity	abdominal fascia	A fascia that is part of a abdomen.	FMA:19841	hp.json	fascia of abdomen|endo-abdominopelvic fascia	http://purl.obolibrary.org/obo/UBERON_0013493		
UBERON:0013498	biolink:AnatomicalEntity	vestibulo-cochlear VIII ganglion complex		EHDAA2:0004313|EMAPA:17570	hp.json	vestibulocochlear VIII ganglion complex|vestibulocochlear ganglion complex|vestibular VIII ganglion complex	http://purl.obolibrary.org/obo/UBERON_0013498		
CHEBI:24654	biolink:ChemicalSubstance	hydroxy fatty acid	Any fatty acid carrying one or more hydroxy substituents.	PMID:18296335|LIPID_MAPS_class:LMFA0105|PMID:6419288|PMID:8274032	hp.json	hydroxy fatty acids	http://purl.obolibrary.org/obo/CHEBI_24654		3_STAR
CHEBI:24651	biolink:ChemicalSubstance	hydroxides	Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)).		hp.json		http://purl.obolibrary.org/obo/CHEBI_24651		3_STAR
GO:0060501	biolink:BiologicalProcess	positive regulation of epithelial cell proliferation involved in lung morphogenesis	Any process that increases the rate or frequency of epithelial cell proliferation that results in the lung attaining its shape.		hp.json		http://purl.obolibrary.org/obo/GO_0060501		
GO:0060502	biolink:BiologicalProcess	epithelial cell proliferation involved in lung morphogenesis	The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population that contributes to the shaping of the lung.		hp.json		http://purl.obolibrary.org/obo/GO_0060502		
CHEBI:24621	biolink:ChemicalSubstance	hormone	Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.		hp.json	hormones|endocrine	http://purl.obolibrary.org/obo/CHEBI_24621		3_STAR
UBERON:0013472	biolink:AnatomicalEntity	upper esophagus	The upper one third of esophagus in which the muscle layer is composed of muscle cells of the striated type.	NCIT:C12253|UMLS:C0227187	hp.json	proximal part of esophagus|upper third of esophagus	http://purl.obolibrary.org/obo/UBERON_0013472		
CHEBI:36608	biolink:ChemicalSubstance	acyclic acid anhydride			hp.json	acyclic anhydrides|acyclic acid anhydride|acyclic acid anhydrides|acyclic acid anhydrides	http://purl.obolibrary.org/obo/CHEBI_36608		3_STAR
UBERON:0013479	biolink:AnatomicalEntity	lung endothelium	A blood vessel endothelium that is part of a lung [Automatically generated definition].	BTO:0004128|CALOHA:TS-0573	hp.json	respiratory endothelium	http://purl.obolibrary.org/obo/UBERON_0013479		
CHEBI:36606	biolink:ChemicalSubstance	acid anhydride	Compounds consisting of two acyl groups bonded to the same oxygen atom acyl-O-acyl.		hp.json	acid anhydrides|acid anhydrides|anhydride d'acide|acid anhydride	http://purl.obolibrary.org/obo/CHEBI_36606		3_STAR
UBERON:0013475	biolink:AnatomicalEntity	gustatory gland	A serous salivary gland which resides adjacent to the moats surrounding the circumvallate papillae in the posterior one-third of the tongue, anterior to the terminal sulcus.	FMA:293448	hp.json	von Ebner gland|posterior deep lingual gland|von Ebner's gland|posterior lingual serous gland	http://purl.obolibrary.org/obo/UBERON_0013475		pheno_slim
UBERON:0001491	biolink:AnatomicalEntity	wrist joint	A joint connecting the forelimb zeugopod skeleton with the carpal skeleton.	FMA:321842|EMAPA:19205|OpenCyc:Mx4rvZD2PJwpEbGdrcN5Y29ycA|UMLS:C1322271|MESH:D014955|galen:WristJoint|NCIT:C33894|GAID:274|MA:0000460	hp.json	joint of wrist|radiocarpal joint|joint of carpal region|carpal region joint	http://purl.obolibrary.org/obo/UBERON_0001491		uberon_slim
UBERON:0001490	biolink:AnatomicalEntity	elbow joint	A joint that connects the forelimb zeugopod and stylopod skeletons[Obol].	FMA:35289|UMLS:C0013770|GAID:253|EMAPA:19102|NCIT:C32497|MA:0000451|VHOG:0000997|galen:ElbowJoint|MESH:D004551	hp.json	articulatio cubiti|joint of cubital region|joint of elbow|cubital region joint	http://purl.obolibrary.org/obo/UBERON_0001490		uberon_slim|pheno_slim
UBERON:0001493	biolink:AnatomicalEntity	axillary nerve	The axillary nerve is a nerve of the human body, that comes off the posterior cord of the brachial plexus at the level of the axilla (armpit) and carries nerve fibers from C5 and C6. The axillary nerve travels through the quadrangular space with the posterior circumflex humeral artery and vein. [WP,unvetted].	OpenCyc:Mx4rvgwMfpwpEbGdrcN5Y29ycA|EMAPA:18802|UMLS:C0228885|MA:0001166|NCIT:C52817|FMA:37072	hp.json	circumflex nerve|auxillery nerve|nervus axillaris|circumflex humeral nerve|nervus axillaris	http://purl.obolibrary.org/obo/UBERON_0001493		human_reference_atlas|uberon_slim
UBERON:0001492	biolink:AnatomicalEntity	radial nerve	A nerve that supplies the upper limb, including the triceps brachii muscle of the arm, as well as all 12 muscles in the posterior osteofascial compartment of the forearm, as well as the associated joints and overlying skin.	MA:0001171|GAID:845|MESH:D011826|NCIT:C52812|FMA:37069|OpenCyc:Mx4rvfk7E5wpEbGdrcN5Y29ycA|EMAPA:17278|EHDAA2:0001584|UMLS:C0034518|EHDAA:5650|VHOG:0000896	hp.json	nervus radialis	http://purl.obolibrary.org/obo/UBERON_0001492		uberon_slim|human_reference_atlas
GO:0060536	biolink:BiologicalProcess	cartilage morphogenesis	The process in which the anatomical structures of cartilage are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060536		
UBERON:0001499	biolink:AnatomicalEntity	muscle of arm	A muscle organ that is part of an arm [Automatically generated definition].	EHDAA:8277|RETIRED_EHDAA2:0000142|EMAPA:36053|MA:0000594	hp.json	muscle of upper arm or lower arm|arm skeletal muscle|arm muscle system|arm skeletal muscle tissue|upper arm / lower arm muscle|arm muscle	http://purl.obolibrary.org/obo/UBERON_0001499		pheno_slim
GO:0060537	biolink:BiologicalProcess	muscle tissue development	The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.		hp.json		http://purl.obolibrary.org/obo/GO_0060537		
UBERON:0001498	biolink:AnatomicalEntity	muscle of pes	Any muscle organ that is part of a pes [Automatically generated definition].	BTO:0000477|FMA:37369|MA:0000652|EMAPA:36160	hp.json	muscle of foot|foot muscle organ|foot muscle|muscle organ of foot	http://purl.obolibrary.org/obo/UBERON_0001498		
GO:0060538	biolink:BiologicalProcess	skeletal muscle organ development	The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0060538		
CHEBI:24628	biolink:ChemicalSubstance	imidazolidine-2,4-dione	An imidazolidinone with oxo groups at position 2 and 4.		hp.json		http://purl.obolibrary.org/obo/CHEBI_24628		3_STAR
GO:0060539	biolink:BiologicalProcess	diaphragm development	The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.		hp.json		http://purl.obolibrary.org/obo/GO_0060539		
UBERON:0001495	biolink:AnatomicalEntity	pectoral muscle	Muscles of the upper chest. The term may refer to one of two muscles, the pectoralis major and pectoralis minor. The former is a thick muscle in the anterior portion of the chest. Its action involves flexion, medial rotation, and adduction of the humerus. The latter is a thin muscle located beneath the pectoralis major. Its action involves lowering the scapula and raising the ribs.	FMA:37349|BTO:0000023|AAO:0010727|CALOHA:TS-0751|MESH:D010369|EMAPA:35670|MA:0002423|GAID:153|UMLS:C0030747|NCIT:C33286	hp.json	muscle of pectoral region|muscle of pectoral part of chest|pectoralis group muscle|breast muscle|M. pectoralis|pectoralis muscle|pectoralis	http://purl.obolibrary.org/obo/UBERON_0001495		uberon_slim|grouping_class|pheno_slim
UBERON:0001497	biolink:AnatomicalEntity	muscle of pelvic girdle	Any muscle organ that is part of a pelvic girdle [Automatically generated definition].	EMAPA:18185|EMAPA:18184|MA:0000537|FMA:37367|RETIRED_EHDAA2:0001430|EHDAA:8326	hp.json	pelvic girdle skeletal muscle|muscle organ of girdle-pelvic|pelvic girdle muscle organ|pelvic girdle muscle|muscle organ of pelvic girdle bone|muscle organ of pelvic girdle|girdle-pelvic muscle organ	http://purl.obolibrary.org/obo/UBERON_0001497		pheno_slim
UBERON:0001496	biolink:AnatomicalEntity	ascending aorta	The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta[GO]. A portion of the aorta commencing at the upper part of the base of the left ventricle, on a level with the lower border of the third costal cartilage behind the left half of the sternum; it passes obliquely upward, forward, and to the right, in the direction of the heart's axis, as high as the upper border of the second right costal cartilage, describing a slight curve in its course, and being situated, about 6 cm behind the posterior surface of the sternum. The total length is about 5 cm in length [Wikipedia].	MA:0002570|NCIT:C32150|OpenCyc:Mx4rwVFqO5wpEbGdrcN5Y29ycA|EHDAA:9828|EMAPA:17014|EHDAA2:0000147|UMLS:C0003956|FMA:3736	hp.json	pars ascendens aortae|pars ascendens aortae|aorta ascendens|ascending thoracic aorta	http://purl.obolibrary.org/obo/UBERON_0001496		human_reference_atlas|uberon_slim|pheno_slim
CHEBI:24632	biolink:ChemicalSubstance	hydrocarbon	A compound consisting of carbon and hydrogen only.		hp.json	Kohlenwasserstoff|hidrocarburo|hidrocarburos|hydrocarbon|Kohlenwasserstoffe|hydrocarbure|hydrocarbons	http://purl.obolibrary.org/obo/CHEBI_24632		3_STAR
UBERON:0001480	biolink:AnatomicalEntity	proximal carpal bone	A carpal bone that proximally_connected_to a forelimb zeugopod skeleton.	FMA:33302|MA:0002557|EMAPA:36164	hp.json		http://purl.obolibrary.org/obo/UBERON_0001480		
UBERON:0001482	biolink:AnatomicalEntity	muscle of shoulder	Any muscle organ that is part of a shoulder [Automatically generated definition].	FMA:33531|MA:0000633|EMAPA:36154	hp.json	shoulder muscle organ|shoulder muscle|muscle organ of shoulder	http://purl.obolibrary.org/obo/UBERON_0001482		
UBERON:0001481	biolink:AnatomicalEntity	distal carpal bone	A distal carpal endochondral element that is composed primarily of a bone tissue.	FMA:33303|MA:0002558|AAO:0000847|EMAPA:36168	hp.json	distal carpal	http://purl.obolibrary.org/obo/UBERON_0001481		
GO:0072507	biolink:BiologicalProcess	divalent inorganic cation homeostasis	Any process involved in the maintenance of an internal steady state of divalent cations within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0072507		
GO:0072506	biolink:BiologicalProcess	trivalent inorganic anion homeostasis	Any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0072506		
GO:0072505	biolink:BiologicalProcess	divalent inorganic anion homeostasis	Any process involved in the maintenance of an internal steady state of divalent inorganic anions within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0072505		
UBERON:0001488	biolink:AnatomicalEntity	ankle joint	A joint that connects the hindlimb autopod and zeugopod skeletons.	NCIT:C32078|UMLS:C0003087|OpenCyc:Mx4rvwiy35wpEbGdrcN5Y29ycA|EMAPA:35126|galen:AnkleJoint|GAID:257|MESH:D000843|BTO:0004706|FMA:35195|MA:0000463	hp.json	gambrel|hock joint|talotibial joint|talocrural articulation|mortise joint|hock|talocrural joint	http://purl.obolibrary.org/obo/UBERON_0001488		efo_slim|uberon_slim
UBERON:0001487	biolink:AnatomicalEntity	pes joint	A skeletal joint that is part of a pes [Automatically generated definition].	MESH:D033023|EMAPA:32949|GAID:256|MA:0000464|FMA:35194	hp.json	foot joint|pedal joint|articulationes pedis|joints of foot|hind limb autopod joint|joint of pes|joint of terminal segment of free lower limb	http://purl.obolibrary.org/obo/UBERON_0001487		pheno_slim
GO:0072503	biolink:BiologicalProcess	cellular divalent inorganic cation homeostasis	Any process involved in the maintenance of an internal steady state of divalent cations at the level of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0072503		
GO:0072502	biolink:BiologicalProcess	cellular trivalent inorganic anion homeostasis	Any process involved in the maintenance of an internal steady state of trivalent inorganic anions at the level of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0072502		
GO:0072501	biolink:BiologicalProcess	cellular divalent inorganic anion homeostasis	Any process involved in the maintenance of an internal steady state of divalent inorganic anions at the level of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0072501		
UBERON:0001489	biolink:AnatomicalEntity	manus joint	A skeletal joint that is part of a manus (hand) [Automatically generated definition].	EMAPA:32641|MA:0000452	hp.json	joint of terminal segment of free upper limb|hand joint|joint of manus|articulationes manus|joint of hand|manual joint	http://purl.obolibrary.org/obo/UBERON_0001489		pheno_slim
UBERON:0001484	biolink:AnatomicalEntity	articular capsule	An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted].	EMAPA:37621|MA:0001519|UMLS:C0206207|galen:JointCapsule|Wikipedia:Articular_capsule|NCIT:C32259|NCIT:C84388|SCTID:182238002|GAID:263|MESH:D017746|FMA:34836	hp.json	capsulae articulares|joint capsule|capsulae articulares|capsula articularis|joint fibrous capsule|fibrous capsule of joint	http://purl.obolibrary.org/obo/UBERON_0001484		uberon_slim|organ_slim
UBERON:0001483	biolink:AnatomicalEntity	skin of shoulder	A zone of skin that is part of a shoulder region.	FMA:34830|MA:0000635|EMAPA:18059	hp.json	shoulder zone of skin|shoulder skin|zone of skin of shoulder	http://purl.obolibrary.org/obo/UBERON_0001483		
UBERON:0001486	biolink:AnatomicalEntity	hip joint	A synovial joint that connects the femur to the acetbulum of the innominate bone.	MA:0000470|MESH:D006621|UMLS:C0019558|VHOG:0001001|FMA:35178|OpenCyc:Mx4rwP32b5wpEbGdrcN5Y29ycA|NCIT:C32742|EMAPA:19136|galen:HipJoint|GAID:262|BTO:0001502	hp.json	femoro-iliac joint|articulatio coxofemoralis|coxal articulation	http://purl.obolibrary.org/obo/UBERON_0001486		pheno_slim|uberon_slim
UBERON:0001485	biolink:AnatomicalEntity	knee joint	The knee joint joins the thigh with the leg and consists of two articulations: one between the femur and tibia, and one between the femur and patella. It is the largest and most complicated joint in the human body. The knee is a mobile trocho-ginglymus (i.e. a pivotal hinge joint), which permits flexion and extension as well as a slight medial and lateral rotation[WP,unvetted].	MA:0000471|galen:KneeJoint|VHOG:0001003|GAID:114|MESH:D007719|UMLS:C0022745|NCIT:C32898|EFO:0001957|EMAPA:19137|FMA:35175|OpenCyc:Mx4rwCuaYZwpEbGdrcN5Y29ycA	hp.json	articulatio genus|joint of knee	http://purl.obolibrary.org/obo/UBERON_0001485		pheno_slim|efo_slim|human_reference_atlas|uberon_slim
HP:0030091	biolink:PhenotypicFeature	Absent muscle fiber merosin	Lack of merosin protein in the muscle biopsy.	UMLS:C4021055	hp.json	Absent muscle fibre merosin|Absent muscle fibre laminin alpha 2|Absent muscle fiber laminin alpha 2|Absent merosin staining in muscle biopsy	http://purl.obolibrary.org/obo/HP_0030091		
HP:0030092	biolink:PhenotypicFeature	Reduced muscle fiber merosin	A reduced amount of merosin in muscle fibers. This feature is usually assessed by immunohistochemical examination of muscle biopsy tissue.	UMLS:C4022651	hp.json	Reduced muscle fibre merosin	http://purl.obolibrary.org/obo/HP_0030092		
HP:0030093	biolink:PhenotypicFeature	Abnormal muscle fiber laminin beta 1	A deviation from normal of the amount of laminin beta 1 in muscle fiber tissue. Laminin 2 is a major component of the basal lamina of skeletal muscle cells. It is a heterotrimer composed of 3 chains: merosin (laminin alpha 2 chain), beta 1, and gamma 1.	UMLS:C4022650	hp.json	Abnormal muscle fibre laminin beta 1	http://purl.obolibrary.org/obo/HP_0030093		
HP:0030094	biolink:PhenotypicFeature	Reduced muscle fiber laminin beta 1	A reduced amount of laminin beta 1 in muscle fiber tissue. Laminin 2 is a major component of the basal lamina of skeletal muscle cells. It is a heterotrimer composed of 3 chains: merosin (laminin alpha 2 chain), beta 1, and gamma 1.	UMLS:C4022649	hp.json	Reduced muscle fibre laminin beta 1	http://purl.obolibrary.org/obo/HP_0030094		
HP:0030090	biolink:PhenotypicFeature	Abnormal muscle fiber merosin expression	An anomalous amount of merosin in muscle fibers. Merosin is a basement membrane-associated protein found in placenta, striated muscle, and peripheral nerve.	UMLS:C4022652	hp.json	Abnormal muscle fibre merosin expression	http://purl.obolibrary.org/obo/HP_0030090		
GO:1901402	biolink:BiologicalProcess	negative regulation of tetrapyrrole metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of tetrapyrrole metabolic process.		hp.json	down regulation of tetrapyrrole metabolic process|inhibition of tetrapyrrole metabolic process|down-regulation of tetrapyrrole metabolic process|down-regulation of tetrapyrrole metabolism|negative regulation of tetrapyrrole metabolism|down regulation of tetrapyrrole metabolism|downregulation of tetrapyrrole metabolism|downregulation of tetrapyrrole metabolic process|inhibition of tetrapyrrole metabolism	http://purl.obolibrary.org/obo/GO_1901402		
HP:0030099	biolink:PhenotypicFeature	Reduced muscle fiber alpha dystroglycan	Immunohistochemistry reveals reduced alpha dystroglycan protein in the muscle biopsy. Alpha-dystroglycan is a heavily glycosylated peripheral-membrane component of the dystrophin-associated glycoprotein complex (DAPC), which, in addition to laminin alpha2, binds perlecan and agrin in the extracellular matrix, whereas beta-dystroglycan, derived from the same gene, is a transmembrane protein that links to dystrophin intracellularly.	UMLS:C4022646	hp.json	Reduced muscle fibre alpha dystroglycan	http://purl.obolibrary.org/obo/HP_0030099		
GO:1901403	biolink:BiologicalProcess	positive regulation of tetrapyrrole metabolic process	Any process that activates or increases the frequency, rate or extent of tetrapyrrole metabolic process.		hp.json	upregulation of tetrapyrrole metabolism|upregulation of tetrapyrrole metabolic process|activation of tetrapyrrole metabolism|up regulation of tetrapyrrole metabolic process|up-regulation of tetrapyrrole metabolism|up-regulation of tetrapyrrole metabolic process|up regulation of tetrapyrrole metabolism|activation of tetrapyrrole metabolic process|positive regulation of tetrapyrrole metabolism	http://purl.obolibrary.org/obo/GO_1901403		
GO:1901401	biolink:BiologicalProcess	regulation of tetrapyrrole metabolic process	Any process that modulates the frequency, rate or extent of tetrapyrrole metabolic process.		hp.json	regulation of tetrapyrrole metabolism	http://purl.obolibrary.org/obo/GO_1901401		
HP:0030095	biolink:PhenotypicFeature	Reduced muscle collagen VI	A decreased amount of collagen VI in muscle tissue. Collagen VI is a primarily associated with the extracellular matrix of skeletal muscle.	UMLS:C4021054	hp.json	Reduced collagen 6 in muscle	http://purl.obolibrary.org/obo/HP_0030095		
HP:0030096	biolink:PhenotypicFeature	Abnormal muscle fiber dystrophin expression	A deviation from normal in the amount of dystrophin in muscle fiber tissue. Dystrophin is located at the muscle sarcolemma in a membrane-spanning protein complex that connects the cytoskeleton to the basal lamina.	UMLS:C4022648	hp.json	Abnormal muscle fibre dystrophin expression	http://purl.obolibrary.org/obo/HP_0030096		
HP:0030097	biolink:PhenotypicFeature	Absent muscle dystrophin expression	Lack of dystrophin in muscle tissue. Immunohistochemistry reveals absent dystrophin protein in the muscle biopsy.	UMLS:C4022647	hp.json		http://purl.obolibrary.org/obo/HP_0030097		
HP:0030098	biolink:PhenotypicFeature	Reduced muscle dystrophin expression	A decreased amount of dystrophin in muscle fiber tissue.	UMLS:C4021053	hp.json	Reduced dystrophin staining in muscle	http://purl.obolibrary.org/obo/HP_0030098		
GO:0072537	biolink:BiologicalProcess	fibroblast activation	A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.		hp.json		http://purl.obolibrary.org/obo/GO_0072537		
CHEBI:24610	biolink:ChemicalSubstance	homocysteines			hp.json		http://purl.obolibrary.org/obo/CHEBI_24610		1_STAR
CHEBI:24612	biolink:ChemicalSubstance	homocystines	A non-proteinogenic alpha-amino acid obtained by oxidative dimerisation of homocysteine and its derivatives.		hp.json		http://purl.obolibrary.org/obo/CHEBI_24612		3_STAR
GO:0060540	biolink:BiologicalProcess	diaphragm morphogenesis	The process in which the anatomical structures of the diaphragm are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060540		
GO:0060541	biolink:BiologicalProcess	respiratory system development	The progression of the respiratory system over time from its formation to its mature structure. The respiratory system carries out respiratory gaseous exchange.		hp.json		http://purl.obolibrary.org/obo/GO_0060541		goslim_drosophila
GO:0072527	biolink:BiologicalProcess	pyrimidine-containing compound metabolic process	The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof.		hp.json	pyrimidine-containing compound metabolism|pyrimidine and derivative metabolic process	http://purl.obolibrary.org/obo/GO_0072527		
GO:0060548	biolink:BiologicalProcess	negative regulation of cell death	Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.		hp.json		http://purl.obolibrary.org/obo/GO_0060548		
GO:0072521	biolink:BiologicalProcess	purine-containing compound metabolic process	The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.		hp.json	purine-containing compound metabolism|purine and derivative metabolic process	http://purl.obolibrary.org/obo/GO_0072521		
GO:0060571	biolink:BiologicalProcess	morphogenesis of an epithelial fold	The morphogenetic process in which an epithelial sheet bends along a linear axis.		hp.json	folding of an epithelial sheet|epithelial folding	http://purl.obolibrary.org/obo/GO_0060571		
UBERON:0037447	biolink:AnatomicalEntity	wall of male urethra		FMA:19676	hp.json	male urethral wall	http://purl.obolibrary.org/obo/UBERON_0037447		
GO:0060572	biolink:BiologicalProcess	morphogenesis of an epithelial bud	The morphogenetic process in which a bud forms from an epithelial sheet. A bud is a protrusion that forms form the sheet by localized folding.		hp.json		http://purl.obolibrary.org/obo/GO_0060572		
GO:0060574	biolink:BiologicalProcess	intestinal epithelial cell maturation	The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell of the intestine to attain its fully functional state. A columnar/cuboidal epithelial cell of the intestine mature as they migrate from the intestinal crypt to the villus.		hp.json		http://purl.obolibrary.org/obo/GO_0060574		
GO:0060575	biolink:BiologicalProcess	intestinal epithelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell of the intestine.		hp.json		http://purl.obolibrary.org/obo/GO_0060575		
GO:0060576	biolink:BiologicalProcess	intestinal epithelial cell development	The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell of the intestine over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0060576		
GO:0060577	biolink:BiologicalProcess	pulmonary vein morphogenesis	The process in which the anatomical structure of the pulmonary venous blood vessels are generated and organized. Pulmonary veins are blood vessels that transport blood from the lungs to the heart.		hp.json	pulmonary venous blood vessel morphogenesis	http://purl.obolibrary.org/obo/GO_0060577		
GO:0060578	biolink:BiologicalProcess	superior vena cava morphogenesis	The process in which the anatomical structure of superior vena cava generated and organized. The superior vena cava is a blood vessel that transports blood from the upper body to the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0060578		
NCBITaxon:1338369	biolink:OrganismalEntity	Dipnotetrapodomorpha		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_1338369		
SO:0000010	biolink:SequenceFeature	protein_coding			hp.json	protein-coding	http://purl.obolibrary.org/obo/SO_0000010		
UBERON:0037455	biolink:AnatomicalEntity	wall of female urethra		FMA:19780	hp.json	female urethral wall	http://purl.obolibrary.org/obo/UBERON_0037455		
UBERON:0037459	biolink:AnatomicalEntity	hair of limb		FMA:54243	hp.json	limb hair	http://purl.obolibrary.org/obo/UBERON_0037459		
GO:0060560	biolink:BiologicalProcess	developmental growth involved in morphogenesis	The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape.		hp.json	differential growth	http://purl.obolibrary.org/obo/GO_0060560		
UBERON:0037458	biolink:AnatomicalEntity	hair of neck		FMA:54242	hp.json	neck hair	http://purl.obolibrary.org/obo/UBERON_0037458		
GO:0060561	biolink:BiologicalProcess	apoptotic process involved in morphogenesis	Any apoptotic process that contributes to the shaping of an anatomical structure.		hp.json	apoptosis involved in development|apoptosis involved in morphogenesis|morphogenetic apoptosis	http://purl.obolibrary.org/obo/GO_0060561		
GO:0060562	biolink:BiologicalProcess	epithelial tube morphogenesis	The process in which the anatomical structures of a tube are generated and organized from an epithelium. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.		hp.json		http://purl.obolibrary.org/obo/GO_0060562		
GO:0060563	biolink:BiologicalProcess	neuroepithelial cell differentiation	The process in which epiblast cells acquire specialized features of neuroepithelial cells.		hp.json		http://purl.obolibrary.org/obo/GO_0060563		
HP:0032470	biolink:PhenotypicFeature	Monilethrix	The hair shaft has a beaded appearance due to the presence of elliptical nodes that have the diameter of normal hair and are medullated, regularly separated by internodes that are narrow, devoid of medulla and are the site of fracture.		hp.json		http://purl.obolibrary.org/obo/HP_0032470		
UBERON:0003728	biolink:AnatomicalEntity	mediastinum	The central part of the thoracic cavity enclosed by the left and right pleurae.	EMAPA:36001|MESH:D008482|UMLS:C0025066|MA:0003075|OpenCyc:Mx4rv2OKJ5wpEbGdrcN5Y29ycA|CALOHA:TS-2338|EFO:0003057|FMA:9826|NCIT:C12748|GAID:94	hp.json	mediastinal part of chest	http://purl.obolibrary.org/obo/UBERON_0003728		pheno_slim|efo_slim
UBERON:0003729	biolink:AnatomicalEntity	mouth mucosa	A mucous membrane that lines the mouth.	GAID:951|Wikipedia:Oral_mucosa|FMA:59660|MA:0002794|CALOHA:TS-0716|EMAPA:26937|MESH:D009061|BTO:0002860|UMLS:C0026639|NCIT:C77637	hp.json	oral part of viscerocranial mucosa|mouth mucosa|buccal mucosa|oral mucosa|tunica mucosa oris|oral mucous membrane|tunica mucosa oris|mucosa of mouth|mouth organ mucosa|mucosal lining of mouth|mouth mucous membrane|tunica mucosa oris|mucous membrane of mouth	http://purl.obolibrary.org/obo/UBERON_0003729		pheno_slim
CHEBI:48578	biolink:ChemicalSubstance	radical scavenger	A role played by a substance that can react readily with, and thereby eliminate, radicals.		hp.json	free radical scavengers|free-radical scavenger	http://purl.obolibrary.org/obo/CHEBI_48578		3_STAR
UBERON:0003726	biolink:AnatomicalEntity	thoracic nerve	The twelve spinal nerves on each side of the thorax. They include eleven INTERCOSTAL NERVES and one subcostal nerve. Both sensory and motor, they supply the muscles and skin of the thoracic and abdominal walls.	OpenCyc:Mx4rwSJp_ZwpEbGdrcN5Y29ycA|MESH:D013900|FMA:5860|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1725|GAID:857|SCTID:360498003|Wikipedia:Thoracic_nerves	hp.json	nervi thoracici|thoracic spinal nerve|nervi thoracici|pectoral nerve|nervus thoracis	http://purl.obolibrary.org/obo/UBERON_0003726		
UBERON:0003727	biolink:AnatomicalEntity	intercostal nerve	The intercostal nerves are the anterior divisions (rami anteriores; ventral divisions) of the thoracic spinal nerves from T1 to T11. Each nerve is connected with the adjoining ganglion of the sympathetic trunk by a gray and a white ramus communicans. The intercostal nerves are distributed chiefly to the thoracic pleura and abdominal peritoneum and differ from the anterior divisions of the other spinal nerves in that each pursues an independent course without plexus formation. The first two nerves supply fibers to the upper limb in addition to their thoracic branches; the next four are limited in their distribution to the parietes of the thorax; the lower five supply the parietes of the thorax and abdomen. The 7th intercostal nerve terminates at the xyphoid process, at the lower end of the sternum. The 10th intercostal nerve terminates at the umbilicus. The twelfth thoracic is distributed to the abdominal wall and groin. [WP,unvetted].	Wikipedia:Intercostal_nerves|GAID:858|MESH:D007367|SCTID:279568001|NCIT:C32825|UMLS:C1285089|EMAPA:18227|FMA:6028	hp.json	nervi intercostales|anterior ramus of thoracic nerve|nervi intercostales|ramus anterior, nervus thoracicus|anterior ramus of thoracic spinal nerve|ventral ramus of thoracic spinal nerve|thoracic anterior ramus	http://purl.obolibrary.org/obo/UBERON_0003727		
UBERON:0003724	biolink:AnatomicalEntity	musculocutaneous nerve	A large branch of the brachial plexus supplying various parts of the upper arm (as flexor muscles) and forearm (as the skin).	FMA:37064|MESH:D009138|GAID:844|OpenCyc:Mx4rvzp0l5wpEbGdrcN5Y29ycA	hp.json	casserio's nerve|nervus musculocutaneus	http://purl.obolibrary.org/obo/UBERON_0003724		human_reference_atlas
UBERON:0003725	biolink:AnatomicalEntity	cervical nerve plexus	An arrangement of nerve fibers, running from the spine that travels to the head and neck where it innervates skin and muscle.	OpenCyc:Mx4rvkEE3JwpEbGdrcN5Y29ycA|BAMS:cep|FMA:5904|GAID:847|MESH:D002572	hp.json	cervical plexus|plexus cervicalis|plexus cervicalis|cervical nerve plexus	http://purl.obolibrary.org/obo/UBERON_0003725		human_reference_atlas
HP:0032476	biolink:PhenotypicFeature	Abnormal circulating vitamin B6 level	An abnormal concentration of vitamin B6 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032476		
GO:0035702	biolink:BiologicalProcess	monocyte homeostasis	The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0035702		
HP:0032475	biolink:PhenotypicFeature	6-layered lissencephaly			hp.json		http://purl.obolibrary.org/obo/HP_0032475		
HP:0032478	biolink:PhenotypicFeature	Lateral spinal meningocele	Protrusion of the arachnoid and dura through spinal foramina.		hp.json		http://purl.obolibrary.org/obo/HP_0032478		
HP:0032477	biolink:PhenotypicFeature	Elevated circulating vitamin B6 level	An abnormally increased concentration of vitamin B6 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032477		
HP:0032472	biolink:PhenotypicFeature	Abnormal urine urobilinogen level	An abnormal concentration of urobilinogen in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032472		
HP:0032471	biolink:PhenotypicFeature	Focal polymicrogyria	Polymicrogyria affecting one or multiple small areas of the cerebral cortex.		hp.json		http://purl.obolibrary.org/obo/HP_0032471		
HP:0032473	biolink:PhenotypicFeature	Decreased urine urobilinogen	An abnormally reduced concentration of urobilinogen in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032473		
CHEBI:36586	biolink:ChemicalSubstance	carbonyl compound	Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives.		hp.json	carbonyl compounds	http://purl.obolibrary.org/obo/CHEBI_36586		3_STAR
CHEBI:36587	biolink:ChemicalSubstance	organic oxo compound	Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element.		hp.json	oxo compounds|organic oxo compounds	http://purl.obolibrary.org/obo/CHEBI_36587		3_STAR
HP:0032479	biolink:PhenotypicFeature	Preimplantation lethality	It is estimated that about 40-70 percent of human embryos produced in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are viable embryos, whereas others arrest at different early stages of development. The phenotype of preimplantation lethality is inferred if IVF and ICSI cycles fail because all of an individual's embryos are arrested at early stages of development.		hp.json	Preimplantation embryonic lethality	http://purl.obolibrary.org/obo/HP_0032479		
GO:0035701	biolink:BiologicalProcess	hematopoietic stem cell migration	The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.		hp.json	hemopoietic stem cell migration	http://purl.obolibrary.org/obo/GO_0035701		
HP:0032481	biolink:PhenotypicFeature	Abnormal pituitary glycoprotein hormone alpha subunit level	Any deviation from the normal concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081).		hp.json		http://purl.obolibrary.org/obo/HP_0032481		
HP:0032480	biolink:PhenotypicFeature	Beta-aminoisobutyric aciduria	An increased amount of beta-aminoisobutyric acid in the urine. Beta-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine.		hp.json		http://purl.obolibrary.org/obo/HP_0032480		
UBERON:0003715	biolink:AnatomicalEntity	splanchnic nerve	The major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia.	EMAPA:37959|Wikipedia:Splanchnic_nerves|FMA:5883|BAMS:spn|SCTID:264198001|MESH:D013153|GAID:800	hp.json	visceral nerve|splanchnic nerves|visceral nerve	http://purl.obolibrary.org/obo/UBERON_0003715		pheno_slim
UBERON:0003716	biolink:AnatomicalEntity	recurrent laryngeal nerve	A branch of the vagus nerve that supplies motor function and sensation to the larynx (voice box). It travels within the endoneurium. It is the nerve of the 6th Branchial Arch.	MESH:D012009|FMA:6246|SCTID:24227007|AAO:0010754|Wikipedia:Recurrent_laryngeal_nerve|GAID:804|VHOG:0001347	hp.json	vagus X nerve recurrent laryngeal branch|ramus recurrens|recurrent nerve|recurrent nerve|nervus laryngeus recurrens|inferior laryngeal nerve|recurrent laryngeal nerve from vagus nerve|nervus laryngeus recurrens	http://purl.obolibrary.org/obo/UBERON_0003716		
UBERON:0003713	biolink:AnatomicalEntity	splenic vein	A vein arising from the splenic trabecular vein in the hilum of the spleen that drains into the portal vein.	OpenCyc:Mx4rwCt0eZwpEbGdrcN5Y29ycA|UMLS:C0038001|FMA:14331|GAID:541|EMAPA:37226|MA:0002164|galen:SplenicVein|SCTID:278029005|NCIT:C33608|Wikipedia:Splenic_vein|MESH:D013162	hp.json	lienal vein|lienal vein|vena lienalis|vena splenica|vena lienalis	http://purl.obolibrary.org/obo/UBERON_0003713		human_reference_atlas
UBERON:0003714	biolink:AnatomicalEntity	neural tissue	Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature.	SCTID:91728009|FMA:9642|AAO:0000325|GAID:609|MESH:D009417|UMLS:C0027757|EHDAA2:0003123|OpenCyc:Mx4rVmfYCsQ_QdeM_bFAeS8NRQ|AEO:0000123|NCIT:C13052	hp.json	portion of neural tissue|nervous tissue|nerve tissue	http://purl.obolibrary.org/obo/UBERON_0003714		
HP:0032487	biolink:PhenotypicFeature	Reduced fecal osmolality	Abnormally low concentration of feces as assessed by the total number of solute particles per kilogram.		hp.json	Reduced faecal osmolality	http://purl.obolibrary.org/obo/HP_0032487		
HP:0032486	biolink:PhenotypicFeature	Elevated fecal osmolality	Abnormally high concentration of feces as assessed by the total number of solute particles per kilogram.		hp.json	Elevated faecal osmolality	http://purl.obolibrary.org/obo/HP_0032486		
CHEBI:48560	biolink:ChemicalSubstance	dopaminergic agent	A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.		hp.json	dopamine agent|dopamine drugs|dopamine drug|dopaminergic agents|dopamine agents	http://purl.obolibrary.org/obo/CHEBI_48560		3_STAR
HP:0032489	biolink:PhenotypicFeature	Elevated fecal pH	Abnormally high fecal pH, i.e., abnormal alkalinity of feces.		hp.json	Elevated faecal pH	http://purl.obolibrary.org/obo/HP_0032489		
HP:0032488	biolink:PhenotypicFeature	Abnormal fecal pH	Any deviation from the normal pH of feces. The pH reflects the acidity or alkalinity of a solution on a logarithmic scale on which 7 is neutral, whereby lower values are more acid and higher values more alkaline.		hp.json	Abnormal faecal pH	http://purl.obolibrary.org/obo/HP_0032488		
CHEBI:131604	biolink:ChemicalSubstance	Mycoplasma genitalium metabolite	Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium.		hp.json	Mycoplasma genitalium metabolites	http://purl.obolibrary.org/obo/CHEBI_131604		3_STAR
HP:0032483	biolink:PhenotypicFeature	obsolete Abnormal fecal test result			hp.json		http://purl.obolibrary.org/obo/HP_0032483		
HP:0032482	biolink:PhenotypicFeature	Decreased pituitary glycoprotein hormone alpha subunit level	An reduced concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081).		hp.json	Decreased pituitary glycoprotein polypeptide alpha subunit level|Decreased pituitary glycoprotein alpha subunit level	http://purl.obolibrary.org/obo/HP_0032482		
HP:0032485	biolink:PhenotypicFeature	Abnormal fecal osmolality	Abnormal concentration of feces as assessed by the total number of solute particles per kilogram.		hp.json	Abnormal faecal osmolality	http://purl.obolibrary.org/obo/HP_0032485		
HP:0032484	biolink:PhenotypicFeature	Elevated fecal sodium	An elevated concentration of sodium in feces.		hp.json	Elevated faecal sodium	http://purl.obolibrary.org/obo/HP_0032484		
UBERON:0003723	biolink:AnatomicalEntity	vestibular nerve	The vestibular nerve is one of the two branches of the Vestibulocochlear nerve (the cochlear nerve being the other). It goes to the semicircular canals via the vestibular ganglion. It receives positional information. Axons of the vestibular nerve synapse in the vestibular nucleus on the lateral floor and wall of the fourth ventricle in the pons and medulla. It arises from bipolar cells in the vestibular ganglion, ganglion of Scarpa, which is situated in the upper part of the outer end of the internal auditory meatus. [WP,unvetted].	NCIT:C12820|MA:0001111|BAMS:vVIIIn|VHOG:0001181|MBA:413|FMA:53401|EHDAA2:0002200|OpenCyc:Mx4rvxAWX5wpEbGdrcN5Y29ycA|EMAPA:17803|DHBA:12869|EHDAA:3749|GAID:840|UMLS:C0042598|MESH:D014725	hp.json	scarpa's ganglion|scarpas ganglion|scarpa ganglion|nervus vestibularis|vestibulocochlear nerve vestibular root|vestibulocochlear VIII nerve vestibular component|vestibular root of acoustic nerve|vestibular root of eighth cranial nerve	http://purl.obolibrary.org/obo/UBERON_0003723		pheno_slim
UBERON:0003721	biolink:AnatomicalEntity	lingual nerve	The lingual nerve is a branch of the mandibular nerve (CN V3), itself a branch of the trigeminal nerve, which supplies sensory innervation to the tongue. It also carries fibers from the facial nerve, which return taste information from the anterior two thirds of the tongue.	MA:0001102|FMA:53218|BAMS:5lg|EMAPA:19168|SCTID:280260006|GAID:835|Wikipedia:Lingual_nerve|MESH:D008036	hp.json	trigeminal V nerve lingual branch|trigeminal nerve lingual branch|lingual branch of trigeminal nerve	http://purl.obolibrary.org/obo/UBERON_0003721		
CHEBI:73541	biolink:ChemicalSubstance	organic heterobicyclic ring	A bicyclic organic group that contains both carbon and hetero atoms.		hp.json	organic heterobicyclic rings	http://purl.obolibrary.org/obo/CHEBI_73541		3_STAR
HP:0032490	biolink:PhenotypicFeature	Decreased fecal pH	Abnormally low fecal pH, i.e., abnormal acidity of feces.		hp.json	Decreased faecal pH	http://purl.obolibrary.org/obo/HP_0032490		
HP:0007490	biolink:PhenotypicFeature	Linear arrays of macular hyperkeratoses in flexural areas		UMLS:C1866031	hp.json		http://purl.obolibrary.org/obo/HP_0007490		
UBERON:0003709	biolink:AnatomicalEntity	circle of Willis	A circle of arteries that supply blood to the brain. The Circle of Willis comprises the following arteries: Anterior cerebral artery (left and right); Anterior communicating artery; Internal carotid artery (left and right); Posterior cerebral artery (left and right); Posterior communicating artery (left and right).The basilar artery and middle cerebral arteries, supplying the brain, are also considered part of the circle.	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1468|EMAPA:37829|OpenCyc:Mx4rwSrCwJwpEbGdrcN5Y29ycA|GAID:486|MESH:D002941|SCTID:362047009|EHDAA:9758|Wikipedia:Circle_of_Willis|FMA:50454|EHDAA2:0000252	hp.json	Willis circle|circulus arteriosus cerebri|arterial circle of Willis|cerebral arterial circle|arterial circle|circulus arteriosus cerebri|arterial circle	http://purl.obolibrary.org/obo/UBERON_0003709		pheno_slim
UBERON:0003706	biolink:AnatomicalEntity	laryngeal vocal fold	Either of two pairs of folds of mucous membrane projecting into the larynx.	EMAPA:19181|MESH:D014827|GAID:344|NCIT:C12822|BTO:0005084|OpenCyc:Mx4rvVieepwpEbGdrcN5Y29ycA|FMA:55457|UMLS:C0042930	hp.json	vocal chord|vocal band|plica vocalis|true vocal cord|vocal cord|vocal fold	http://purl.obolibrary.org/obo/UBERON_0003706		pheno_slim
HP:0032492	biolink:PhenotypicFeature	Anti-myelin oligodendrocyte glycoprotein antibody positivity	Presence of antibodies in the serum that react against myelin oligodendrocyte glycoprotein.		hp.json	Anti-MOG antibody positivity	http://purl.obolibrary.org/obo/HP_0032492		
HP:0032491	biolink:PhenotypicFeature	Increased circulating argininosuccinic acid	An increased level of the non-proteinogenic amino acid argininosuccinic acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032491		
UBERON:0003707	biolink:AnatomicalEntity	sinus of Valsalva	One of the anatomic dilations of the ascending aorta, which occurs just above the aortic valve.	MA:0003051|EMAPA:18625|UMLS:C0503361|NCIT:C33557|GAID:472|MESH:D012850|FMA:3745	hp.json	Petit's sinus|sinus of Otto|sinus aortae|Petit sinus|aortic sinus|sinus aortae|sinus aorta|Valsalva sinus|sinus of Morgagni	http://purl.obolibrary.org/obo/UBERON_0003707		pheno_slim
UBERON:0003704	biolink:AnatomicalEntity	intrahepatic bile duct	Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.	UMLS:C0005401|NCIT:C12677|MA:0001630|GAID:287|MESH:D001653|ZFA:0005169|TAO:0005169|FMA:15766	hp.json	bile duct intrahepatic part|intrahepatic biliary system	http://purl.obolibrary.org/obo/UBERON_0003704		vertebrate_core|pheno_slim
CHEBI:73558	biolink:ChemicalSubstance	D3 vitamins	A vitamin D that is calciol or its hydroxylated metabolites calcidiol and calcitriol. Calciol (also known as vitamin D3) acts as a hormone precursor, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.		hp.json	vitamin D3s|D3 vitamin	http://purl.obolibrary.org/obo/CHEBI_73558		3_STAR
UBERON:0003702	biolink:AnatomicalEntity	inguinal canal	The passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively.	MESH:D007264|UMLS:C0021445|GAID:28|FMA:19928|EMAPA:37881|NCIT:C93029|BTO:0005576	hp.json	canalis inguinalis	http://purl.obolibrary.org/obo/UBERON_0003702		pheno_slim
UBERON:0003703	biolink:AnatomicalEntity	extrahepatic bile duct	Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct.	UMLS:C0206187|MESH:D017734|NCIT:C32573|GAID:281|FMA:14678|MA:0002659	hp.json	extrahepatic biliary system|bile duct extrahepatic part	http://purl.obolibrary.org/obo/UBERON_0003703		vertebrate_core|pheno_slim
HP:0032497	biolink:PhenotypicFeature	Reduced terminal:vellus ratio	A terminal:vellus ratio under 4:1 is characteristic of androgenetic alopecia.		hp.json		http://purl.obolibrary.org/obo/HP_0032497		
HP:0032499	biolink:PhenotypicFeature	Giant neutrophil granules	The presence of abnormally large granules in neutrophils. This finding can be appreciated on a peripheral blood smear. The finding is characteristic of Chediak Higashi syndrome. The giant granules are derived from azurophil granules, whereas peroxidase-negative granules are not involved in their formation.		hp.json		http://purl.obolibrary.org/obo/HP_0032499		
CHEBI:24583	biolink:ChemicalSubstance	hexitol			hp.json	hexitol|hexitols	http://purl.obolibrary.org/obo/CHEBI_24583		3_STAR
HP:0032493	biolink:PhenotypicFeature	Increased circulating trypsinogen	An abnormally high concentration of trypsinogen in the blood circulation.		hp.json	Increased immunoreactive trypsinogen	http://purl.obolibrary.org/obo/HP_0032493		
HP:0032496	biolink:PhenotypicFeature	Elevated terminal:vellus ratio	An increased proportion of terminal hairs compared to vellus hairs.		hp.json		http://purl.obolibrary.org/obo/HP_0032496		
HP:0032495	biolink:PhenotypicFeature	Abnormal terminal:vellus ratio	A deviation from the normal proportion of terminal to vellus hairs.		hp.json		http://purl.obolibrary.org/obo/HP_0032495		
UBERON:0003711	biolink:AnatomicalEntity	brachiocephalic vein	The left and right brachiocephalic veins in the upper chest are formed by the union of each corresponding internal jugular vein and subclavian vein. This is at the level of the sternoclavicular joint. These great vessels merge to form the superior vena cava. The brachiocephalic veins are the major veins returning blood to the superior vena cava.	EHDAA:9868|OpenCyc:Mx4rvz3aUJwpEbGdrcN5Y29ycA|GAID:529|NCIT:C32816|UMLS:C0006095|FMA:4723|MESH:D016121|EHDAA2:0000182|galen:BrachiocephalicVein	hp.json	innominate trunk|innominate vein|venae anonyma|vena brachiocephalica|innominate veins|brachiocephalic venous tree|vena brachiocephalica|innomiate vein|innominate vein|innominate vein	http://purl.obolibrary.org/obo/UBERON_0003711		human_reference_atlas
UBERON:0003712	biolink:AnatomicalEntity	cavernous sinus	The cavernous sinus (or lateral sellar compartment), within the human head, is a large collection of thin-walled veins creating a cavity bordered by the temporal bone of the skull and the sphenoid bone, lateral to the sella turcica.	GAID:532|OpenCyc:Mx4rwKAVGJwpEbGdrcN5Y29ycA|MESH:D002426|EMAPA:19059|UMLS:C0007473|FMA:50772|NCIT:C12690	hp.json	cavernous sinuses|cavernus sinus vein|cavernous sinus syndrome|sinus cavernosus|cavernous|parasellar syndrome	http://purl.obolibrary.org/obo/UBERON_0003712		human_reference_atlas
HP:0007486	biolink:PhenotypicFeature	Cavernous hemangioma of the face		NCIT:C3086|UMLS:C1332863	hp.json		http://purl.obolibrary.org/obo/HP_0007486		
HP:0007489	biolink:PhenotypicFeature	Diffuse telangiectasia	Telangiectases (small dilated blood vessels) with a diffuse localization.	SNOMEDCT_US:125279001|UMLS:C1265776	hp.json	Diffuse telangiectases|Telangiectases, random body distribution	http://purl.obolibrary.org/obo/HP_0007489		
HP:0007488	biolink:PhenotypicFeature	Diffuse skin atrophy		UMLS:C4024863	hp.json		http://purl.obolibrary.org/obo/HP_0007488		
HP:0007483	biolink:PhenotypicFeature	Depigmentation/hyperpigmentation of skin		UMLS:C4024864	hp.json		http://purl.obolibrary.org/obo/HP_0007483		
HP:0007482	biolink:PhenotypicFeature	Generalized papillary lesions		UMLS:C4024865	hp.json	Generalised papillary lesions	http://purl.obolibrary.org/obo/HP_0007482		
HP:0007485	biolink:PhenotypicFeature	Absence of subcutaneous fat	Lack of subcutaneous adipose tissue.	UMLS:C4024855|UMLS:C0241267	hp.json	Lack of fatty tissue below the skin|Absent fat below the skin|General absence of subcutaneous fat	http://purl.obolibrary.org/obo/HP_0007485		
CHEBI:24599	biolink:ChemicalSubstance	histidine derivative	An amino acid derivative resulting from reaction of histidine at the amino group or the carboxy group, or from the replacement of any hydrogen of histidine by a heteroatom. The definition normally excludes peptides containing alanine residues.		hp.json	histidine derivatives	http://purl.obolibrary.org/obo/CHEBI_24599		3_STAR
CHEBI:48540	biolink:ChemicalSubstance	beta-adrenergic drug	Any of the drugs that act on beta-adrenergic receptors.		hp.json	beta-adrenergic drugs	http://purl.obolibrary.org/obo/CHEBI_48540		3_STAR
UBERON:0003700	biolink:AnatomicalEntity	temporomandibular joint	A synovial joint of the jaw that connects the mandible to the temporal bone.	NCIT:C32888|MA:0002899|MESH:D013704|UMLS:C0039493|GAID:272|FMA:54832|EMAPA:19196|BTO:0003674	hp.json	squamosal-dentary joint|dentary-squamosal joint|TMJ|temperomandibular joint|tempero-mandibular joint|temporomandibular|articulatio temporomandibularis|temporomandibular articulation|temporomandibular joint|temporalmandibular joint	http://purl.obolibrary.org/obo/UBERON_0003700		pheno_slim
PR:P08920	biolink:Protein	T-cell surface antigen CD2 (mouse)	A CD2 molecule that is encoded in the genome of mouse.	UniProtKB:P08920	hp.json	mCD2|CD2 (mouse)|LFA-3 receptor (mouse)|T-cell surface antigen T11/Leu-5 (mouse)|LFA-2 (mouse)|Ly-37|Cd2|lymphocyte antigen 37 (mouse)	http://purl.obolibrary.org/obo/PR_P08920		
UBERON:0003701	biolink:AnatomicalEntity	calcaneal tendon	The Achilles tendon is a tendon of the posterior leg. It serves to attach the plantaris, gastrocnemius (calf) and soleus muscles to the calcaneus (heel) bone.	FMA:51061|GAID:277|MA:0002993|MESH:D000125|NCIT:C32043|UMLS:C0001074|EMAPA:35853|OpenCyc:Mx4rvVjNX5wpEbGdrcN5Y29ycA	hp.json	tendo calcaneus|Achilles' tendon|Achilles tendon|calcaneal tendon|Achille's tendon|tendo Achillis	http://purl.obolibrary.org/obo/UBERON_0003701		pheno_slim
HP:0007497	biolink:PhenotypicFeature	Focal friction-related palmoplantar hyperkeratosis	Hyperkeratosis affecting the palm of the hand and the sole of the foot in areas exposed to friction.	UMLS:C1835654	hp.json	Hyperkeratosis, palmoplantar, focal friction-related	http://purl.obolibrary.org/obo/HP_0007497		
HP:0007499	biolink:PhenotypicFeature	Recurrent staphylococcal infections	Increased susceptibility to staphylococcal infections, as manifested by recurrent episodes of staphylococcal infections.	UMLS:C4024862	hp.json	Recurrent staphylococcal infections	http://purl.obolibrary.org/obo/HP_0007499		
HP:0007494	biolink:PhenotypicFeature	Discrete 2 to 5-mm hyper- and hypopigmented macules		UMLS:C1851552	hp.json		http://purl.obolibrary.org/obo/HP_0007494		
HP:0007495	biolink:PhenotypicFeature	Prematurely aged appearance		UMLS:C1857656	hp.json	Precociously senile appearance|Prematurely aged appearance	http://purl.obolibrary.org/obo/HP_0007495		
HP:0032432	biolink:PhenotypicFeature	Increased HDL3c concentration	An elevation above the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032432		
HP:0032431	biolink:PhenotypicFeature	Decreased HDL3b concentration	A reduction below the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032431		
HP:0032434	biolink:PhenotypicFeature	Delayed umbilical cord separation	Separation of the umbilical cord occurs at an abnormally late timepoint.		hp.json	Delayed separation of umbilical cord	http://purl.obolibrary.org/obo/HP_0032434		
UBERON:0015757	biolink:AnatomicalEntity	heterogeneous tissue		FMA:62798	hp.json	portion of heterogeneous tissue	http://purl.obolibrary.org/obo/UBERON_0015757		
HP:0032433	biolink:PhenotypicFeature	Decreased HDL3c concentration	A reduction below the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032433		
UBERON:0015751	biolink:AnatomicalEntity	inferior tarsal muscle	A smooth muscle tissue that is part of a inferior eyelid tarsus.	FMA:49059	hp.json		http://purl.obolibrary.org/obo/UBERON_0015751		
HP:0032430	biolink:PhenotypicFeature	Increased HDL3b concentration	An elevation above the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032430		
CHEBI:36544	biolink:ChemicalSubstance	sialodiosylceramide	A ganglioside in which the number of residues in the oligosaccharide chain is two.		hp.json	sialodiosylceramides	http://purl.obolibrary.org/obo/CHEBI_36544		3_STAR
HP:0032439	biolink:PhenotypicFeature	Airborn particle hypersensitivity	An abnormally increased sensitivity to airborn particles. This can be diagnosed on the basis of the medical history, taking into account seasonality or a relationship to the concentration of airborn particles in the environment of the affected individual. Aerosol challenge is a gold standard of establishment of the symptom. There exist particle hypersensitivity (diesel exhaust, metals, inorganic material) vs. allergen (including pollen dander, etc) hypersensitivity. The responses are usually different and testing for allergen hypersensitivity is done in concert with serum IgE and or skin testing to the suspected allergen.		hp.json		http://purl.obolibrary.org/obo/HP_0032439		
HP:0032436	biolink:PhenotypicFeature	Abnormal C-reactive protein level	Any deviation from the normal concentration of C-reactive protein in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032436		
HP:0032435	biolink:PhenotypicFeature	Neonatal omphalitis	An infection of the umbilicus and/or surrounding tissues occurring in the neonatal period.		hp.json	Umbilical cord stump infection|Omphalitis	http://purl.obolibrary.org/obo/HP_0032435		
GO:0060711	biolink:BiologicalProcess	labyrinthine layer development	The process in which the labyrinthine layer of the placenta progresses, from its formation to its mature state.		hp.json		http://purl.obolibrary.org/obo/GO_0060711		
HP:0032438	biolink:PhenotypicFeature	Platelet anisocytosis	Abnormally increased variability in the size of platelets.		hp.json		http://purl.obolibrary.org/obo/HP_0032438		
HP:0032437	biolink:PhenotypicFeature	Reduced C-reactive protein level	An abnormal decrease of the C-reactive protein level in serum.		hp.json		http://purl.obolibrary.org/obo/HP_0032437		
UBERON:0001114	biolink:AnatomicalEntity	right lobe of liver	The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted].	EHDAA:4001|VHOG:0001424|NCIT:C33481|ZFA:0005173|TAO:0005173|EHDAA2:0001008|UMLS:C0227481|FMA:13362|EMAPA:18311|MA:0000363	hp.json	liver right lobe|lobus hepaticus dexter|right liver lobe|lobus hepatis dexter|second lobe|gall bladder lobe|right hepatic lobe|2nd lobe	http://purl.obolibrary.org/obo/UBERON_0001114		uberon_slim|vertebrate_core
GO:0060713	biolink:BiologicalProcess	labyrinthine layer morphogenesis	The process in which the labyrinthine layer of the placenta is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060713		
UBERON:0001113	biolink:AnatomicalEntity	lobe of liver	Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe.	EMAPA:18306|UMLS:C0447541|FMA:13361|NCIT:C49579|MA:0000360	hp.json	hepatic lobe|liver lobe|lobus hepatis	http://purl.obolibrary.org/obo/UBERON_0001113		
GO:0060714	biolink:BiologicalProcess	labyrinthine layer formation	The developmental process pertaining to the initial formation of the labyrinthine layer of the placenta.		hp.json		http://purl.obolibrary.org/obo/GO_0060714		
GO:0060716	biolink:BiologicalProcess	labyrinthine layer blood vessel development	The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.		hp.json		http://purl.obolibrary.org/obo/GO_0060716		
UBERON:0001115	biolink:AnatomicalEntity	left lobe of liver	The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted].	EHDAA2:0001000|VHOG:0001423|EMAPA:18307|ZFA:0005172|NCIT:C32965|TAO:0005172|UMLS:C0227486|FMA:13363|EHDAA:3995|MA:0000361	hp.json	lobus hepaticus sinister|liver left lobe|lobus hepatis sinister|left hepatic lobe|left liver lobe	http://purl.obolibrary.org/obo/UBERON_0001115		uberon_slim|vertebrate_core
GO:0060717	biolink:BiologicalProcess	chorion development	The biological process whose specific outcome is the progression of a chorion from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The chorion is an extraembryonic membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0060717		
GO:0060718	biolink:BiologicalProcess	chorionic trophoblast cell differentiation	The process in which relatively unspecialized cells of the ectoplacental cone acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.		hp.json		http://purl.obolibrary.org/obo/GO_0060718		
GO:0060719	biolink:BiologicalProcess	chorionic trophoblast cell development	The process whose specific outcome is the progression of the chorionic trophoblast over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0060719		
UBERON:0001112	biolink:AnatomicalEntity	latissimus dorsi muscle	The latissimus dorsi is the larger, flat, dorso-lateral muscle on the trunk, posterior to the arm, and partly covered by the trapezius on its median dorsal region. [WP,unvetted].	NCIT:C33150|FMA:13357|EFO:0003067|EHDAA2:0000932|UMLS:C0224362|EHDAA:8307|EMAPA:18178|MA:0002331|VHOG:0000930	hp.json	latissimi dorsi|dorsal latissimus muscle|musculus latissimus dorsi|musculus latissimus dorsi|latissimus dorsi	http://purl.obolibrary.org/obo/UBERON_0001112		efo_slim|uberon_slim|pheno_slim
UBERON:0001111	biolink:AnatomicalEntity	intercostal muscle	The respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib.	UMLS:C0021724|MESH:D007366|NCIT:C32824|GAID:159|FMA:13354|OpenCyc:Mx4rwQo8QJwpEbGdrcN5Y29ycA|EMAPA:18521|MA:0002324|EHDAA:5988|EHDAA2:0000841|VHOG:0000903|BTO:0005281|EFO:0001368|MA:0003165	hp.json	musculus intercostalis|respiratory muscle|rib muscle|intercostales	http://purl.obolibrary.org/obo/UBERON_0001111		efo_slim|uberon_slim|pheno_slim
HP:0032443	biolink:PhenotypicFeature	Past medical history	In a medical encounter, the physician generally will interview the patient about his or her current problem, and may perform additional testing. The past medical history (PMH) in contrast records information about the patient's medical, personal and family history that might be relevant to the presenting illness or to provide optimal clinical management. The PMH generally includes (if relevant) other major illnesses, hospitalizations, surgeries, injuries, allergies, gynecologic and obstetric history, family history, personal history including occupational history, alcohol and drug use, etc.		hp.json		http://purl.obolibrary.org/obo/HP_0032443		
HP:0032442	biolink:PhenotypicFeature	Blood group O	ABO phenotype O, corresponding to the genotype OO.		hp.json		http://purl.obolibrary.org/obo/HP_0032442		
HP:0032445	biolink:PhenotypicFeature	Pulmonary cyst	A round circumscribed space within a lung that is surrounded by an epithelial or fibrous wall of variable thickness. A cyst usually has a thin and regular wall (less than 2 mm) and contains air, although some may contain fluid.		hp.json	Lung cyst	http://purl.obolibrary.org/obo/HP_0032445		
HP:0032444	biolink:PhenotypicFeature	Status post organ transplantation	The affected individual has received an organ transplant previous to the current medical encounter.		hp.json	s/p organ transplantation	http://purl.obolibrary.org/obo/HP_0032444		
HP:0032441	biolink:PhenotypicFeature	Blood group AB	ABO phenotype AB, corresponding to the genotype AB.		hp.json		http://purl.obolibrary.org/obo/HP_0032441		
HP:0032440	biolink:PhenotypicFeature	Blood group B	ABO phenotype B, corresponding to the genotype BO or BB.		hp.json		http://purl.obolibrary.org/obo/HP_0032440		
HP:0032447	biolink:PhenotypicFeature	Pulmonary bleb	A bleb is a small gas-containing space within the visceral pleura or in the subpleural lung, not larger than 1 cm in diameter. CT findings show a bleb as a thin-walled cystic air space contiguous with the pleura.		hp.json		http://purl.obolibrary.org/obo/HP_0032447		
HP:0032446	biolink:PhenotypicFeature	Pulmonary bulla	Pulmonary bullae are rounded focal regions of emphysema with a thin wall which measure more than 1 cm in diameter. They are often subpleural in location and are typically larger in the apices. In some cases, bullae can be very large and result in compression of adjacent lung tissue. A giant bulla is arbitrarily defined as one that occupies at least one third of the volume of a hemithorax. When large, bullae can simulate pneumothorax. The most common cause is paraseptal emphysema but bullae may also be seen in association with centrilobular emphysema.		hp.json	Pulmonary bullae	http://purl.obolibrary.org/obo/HP_0032446		
HP:0032449	biolink:PhenotypicFeature	Abnormal dermoepidermal hemidesmosome morphology	An abnormal structure or appearance of hemidesmosomes, multiprotein complexes that facilitate the stable adhesion of basal epithelial cells to the underlying basement membrane.		hp.json		http://purl.obolibrary.org/obo/HP_0032449		
HP:0032448	biolink:PhenotypicFeature	Achlorhydria	A condition in which production of hydrochloric acid in the stomach is absent.		hp.json		http://purl.obolibrary.org/obo/HP_0032448		
UBERON:0001103	biolink:AnatomicalEntity	diaphragm	A thin musculomebranous barrier that separates the abdominal and thoracic cavities. Often used for breathing control.	MA:0001904|UMLS:C0011980|EHDAA2:0003495|BTO:0000341|EMAPA:17701|EFO:0000937|Wikipedia:Thoracid_diaphragm|NCIT:C12702|GAID:158|CALOHA:TS-0198|MAT:0000502|FMA:13295|SCTID:181614006|MESH:D003964|OpenCyc:Mx4rvVivz5wpEbGdrcN5Y29ycA|VHOG:0000713|EV:0100376	hp.json	midriff|diaphragm muscle|diaphragm of thorax|phren|thoracic diaphragm	http://purl.obolibrary.org/obo/UBERON_0001103		pheno_slim|efo_slim|uberon_slim|organ_slim
UBERON:0001105	biolink:AnatomicalEntity	clavicle bone	A paired dermal or endochondral bone that is part of the pectoral girdle. The clavicle may be in contact with the interclavicle or coracoid and forms an attachment site for pectoral musculature. [PHENOSCAPE:ad].	NCIT:C12695|AAO:0000761|UMLS:C0008913|GAID:182|MFMO:0000047|MA:0001329|OpenCyc:Mx4rvVjijZwpEbGdrcN5Y29ycA|MESH:D002968|FMA:13321|galen:Clavicle|EMAPA:18721|VHOG:0000849|VSAO:0005031	hp.json	clavicula|clavicle|collar bone|collarbone	http://purl.obolibrary.org/obo/UBERON_0001105		pheno_slim|uberon_slim
GO:0060706	biolink:BiologicalProcess	cell differentiation involved in embryonic placenta development	The process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta.		hp.json		http://purl.obolibrary.org/obo/GO_0060706		
UBERON:0001100	biolink:AnatomicalEntity	pectoralis minor	The Pectoralis minor is a thin, triangular muscle, situated at the upper part of the chest, beneath the Pectoralis major. [WP,unvetted].	NCIT:C33285|EHDAA:8313|UMLS:C0224347|EMAPA:18180|EHDAA2:0001425|VHOG:0000902|MA:0002355|FMA:13109	hp.json	musculus pectoralis minor|supracoracoideus muscle|pectoralis minor muscle|supracoracoideus	http://purl.obolibrary.org/obo/UBERON_0001100		uberon_slim|organ_slim|pheno_slim
HP:0032454	biolink:PhenotypicFeature	Labial melanotic macule	Flat, distinct, discolored area on the lip less than 1 cm wide not associated with a change in the thickness or texture.		hp.json	Labial melanotic freckle	http://purl.obolibrary.org/obo/HP_0032454		
HP:0032453	biolink:PhenotypicFeature	Abnormal lip pigmentation	Abnormal coloring of the lip, whereby the lip discolored, blotchy, or darker or lighter than normal.		hp.json		http://purl.obolibrary.org/obo/HP_0032453		
HP:0032456	biolink:PhenotypicFeature	Unlayered lissencephaly	A type of lissencephaly whereby upon neuropathological examination the cortical plate is severely disorganized with a festooned-like pattern and with neither lamination nor clear demarcation between white and grey matter.		hp.json		http://purl.obolibrary.org/obo/HP_0032456		
HP:0032455	biolink:PhenotypicFeature	Reduced granulocyte CD18 level	Reduced level of CD18 on the granulocyte surface. This feature can be assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0032455		
HP:0032450	biolink:PhenotypicFeature	Positive blood arsenic test	Detection of arsenic in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032450		
HP:0032452	biolink:PhenotypicFeature	Oral melanoacanthoma	Oral melanoacanthoma usually presents as an asymptomatic, ill-defined, rapidly enlarging, macular pigmentation. Although most lesions are heavily pigmented, the coloration may or may not be uniform. Any mucosal site may be affected, but buccal mucosal involvement is most common. Although typically solitary, rare patients may present with multifocal lesions.		hp.json		http://purl.obolibrary.org/obo/HP_0032452		
HP:0032451	biolink:PhenotypicFeature	Oral melanotic macule	Flat, distinct, discolored area of oral mucosal membrane less than 1 cm wide not associated with a change in the thickness or texture of the affected mucosal membrane. The lesions are small, solitary, well-circumscribed and often uniformly pigmented.		hp.json	Melanotic macule of oral mucosa	http://purl.obolibrary.org/obo/HP_0032451		
CHEBI:36520	biolink:ChemicalSubstance	oligoglycosylceramide			hp.json		http://purl.obolibrary.org/obo/CHEBI_36520		1_STAR
HP:0032458	biolink:PhenotypicFeature	Narrowing of medullary canal	A reduction in diameter and volume of the central cavity of bone where red or yellow bone marrow is located.		hp.json	Narrowing of bone marrow canal|Narrowing of bone medullary canal|Medullary cavity obliteration|Narrowing of the marrow cavity	http://purl.obolibrary.org/obo/HP_0032458		
CHEBI:36526	biolink:ChemicalSubstance	acidic glycosphingolipid			hp.json		http://purl.obolibrary.org/obo/CHEBI_36526		1_STAR
HP:0032457	biolink:PhenotypicFeature	2-3-layered lissencephaly	Pachygyria-agyria spectrum whereby at neuropathological examination the cortical plate consists of a two-three layered organization made up of a molecular layer, a relatively thin wavy layer with a higher cellular density and a third layer with lower cellularity.		hp.json		http://purl.obolibrary.org/obo/HP_0032457		
HP:0032459	biolink:PhenotypicFeature	Abnormal phosphoribosylpyrophosphate synthetase level	Any deviation from the normal level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate.		hp.json		http://purl.obolibrary.org/obo/HP_0032459		
HP:0032465	biolink:PhenotypicFeature	Bladder trabeculation	Muscular projections that protrude into the lumen of the bladder, criss-crossing the walls of the bladder on its inner surface.		hp.json	Trabecular bladder	http://purl.obolibrary.org/obo/HP_0032465		
HP:0032464	biolink:PhenotypicFeature	Ureteral hypoplasia	Underdevelopment of the ureter.		hp.json	Ureter hypoplasia|Hypoplasia of the ureter	http://purl.obolibrary.org/obo/HP_0032464		
HP:0032467	biolink:PhenotypicFeature	Past obstetric history	Information about past pregnancies including gravidity (number of times a woman has been pregnant, regardless of the outcome), parity (total number of births), gestational age of births, and medical conditions related to past pregnancies.		hp.json	Maternal medical history	http://purl.obolibrary.org/obo/HP_0032467		
HP:0032466	biolink:PhenotypicFeature	Aplasia of the olfactory bulb	Lack of formation (congenital absence) of the olfactory bulb.		hp.json	Olfactory bulb aplasia|Aplastic olfactory bulb	http://purl.obolibrary.org/obo/HP_0032466		
HP:0032461	biolink:PhenotypicFeature	obsolete Tiger-tail banding			hp.json		http://purl.obolibrary.org/obo/HP_0032461		
HP:0032460	biolink:PhenotypicFeature	Decreased phosphoribosylpyrophosphate synthetase level	Abnormally reduced level of the enzyme phosphoribosyl pyrophosphatesynthetase, which catalyzes the synthesis of PP-ribose-P from ATP and ribose-5-phosphate.		hp.json		http://purl.obolibrary.org/obo/HP_0032460		
HP:0032463	biolink:PhenotypicFeature	Reduced circulating fibronectin level	A reduction below the normal concentration of fibronectin the the blood circulation.		hp.json	Decreased plasma fibronectin	http://purl.obolibrary.org/obo/HP_0032463		
HP:0032462	biolink:PhenotypicFeature	Increased circulating palmitate level	An elevation beyond the normal concentration of palmitate (palmitic acid) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032462		
HP:0032469	biolink:PhenotypicFeature	Anti-asialoglycoprotein receptor antibody positivity	Presence of autoantibodies against the asialoglycoprotein receptor (ASGPR) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032469		
HP:0032468	biolink:PhenotypicFeature	History of stillbirth	One or more previous pregnancies resulted in stillbirth, defined as death of a fetus in the later stages of pregnancy (definitions in the literature vary, with cut-offs ranging from 20 to 28 weeks gestation).		hp.json		http://purl.obolibrary.org/obo/HP_0032468		
GO:0060722	biolink:BiologicalProcess	cell proliferation involved in embryonic placenta development	The multiplication or reproduction of cells, resulting in the expansion of the population in the embryonic placenta.		hp.json		http://purl.obolibrary.org/obo/GO_0060722		
UBERON:0015717	biolink:AnatomicalEntity	smooth muscle tissue layer of ejaculatory duct	A smooth muscle tissue that is part of a ejaculatory duct.	FMA:19372|EMAPA:32289	hp.json	muscle layer of ejaculatory duct	http://purl.obolibrary.org/obo/UBERON_0015717		
UBERON:0015716	biolink:AnatomicalEntity	anal canal epithelium	An epithelium that is part of a anal canal.	EMAPA:18835|FMA:17511	hp.json	anal canal epithelium|epithelium of anal canal	http://purl.obolibrary.org/obo/UBERON_0015716		human_reference_atlas
GO:0060723	biolink:BiologicalProcess	regulation of cell proliferation involved in embryonic placenta development	Any process that modulates the rate, frequency, or extent of cell proliferation involved in embryonic placenta development.		hp.json		http://purl.obolibrary.org/obo/GO_0060723		
PATO:0001973	biolink:NamedThing	cuspidate	A shape quality inhering in a bearer by virtue of the bearer's being tapering gradually into a rigid point.		hp.json		http://purl.obolibrary.org/obo/PATO_0001973		value_slim
PATO:0001977	biolink:NamedThing	angular	A shape quality inhering in a bearer by virtue of the bearer's having at least one salient angle on the margin.		hp.json	angulate	http://purl.obolibrary.org/obo/PATO_0001977		value_slim
HP:0007429	biolink:PhenotypicFeature	Few cafe-au-lait spots	The presence of two to five cafe-au-lait macules.	UMLS:C4024881	hp.json		http://purl.obolibrary.org/obo/HP_0007429		
HP:0007428	biolink:PhenotypicFeature	Telangiectasia of the oral mucosa	Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the oral mucosa.	UMLS:C4024882	hp.json	Telangiectasia of the oral mucous membrane|Angioectasia of the oral mucosa|Angioectasia of the oral mucous membrane|Spider veins of the oral mucosa	http://purl.obolibrary.org/obo/HP_0007428		
HP:0007425	biolink:PhenotypicFeature	Hyperextensible skin of face		UMLS:C4024883	hp.json	Hyperelastic face skin|Stretchable face skin	http://purl.obolibrary.org/obo/HP_0007425		
HP:0007427	biolink:PhenotypicFeature	Reticulated skin pigmentation		UMLS:C3279601|UMLS:C3279575	hp.json	Reticulate skin pigmentation|Reticular pigmentation pattern	http://purl.obolibrary.org/obo/HP_0007427		
HP:0007421	biolink:PhenotypicFeature	Telangiectases of the cheeks	Telangiectases (small dilated blood vessels) located near the surface of the skin of the cheeks.	UMLS:C3554587	hp.json	Telangiectasia on the cheeks	http://purl.obolibrary.org/obo/HP_0007421		
HP:0007420	biolink:PhenotypicFeature	Spontaneous hematomas	Spontaneous development of hematomas (hematoma) or bruises without significant trauma.	UMLS:C1697453	hp.json		http://purl.obolibrary.org/obo/HP_0007420		
GO:0035779	biolink:BiologicalProcess	angioblast cell differentiation	The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells).		hp.json	angioblastic mesenchymal cell differentiation	http://purl.obolibrary.org/obo/GO_0035779		
HP:0032401	biolink:PhenotypicFeature	Aspartic aciduria	A increased concentration of aspartic acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032401		
HP:0032400	biolink:PhenotypicFeature	Dysgyria with thickened cortex	An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation and a thickened cortex intermediate between pachygyria and polymicrogyria.		hp.json		http://purl.obolibrary.org/obo/HP_0032400		
PATO:0001987	biolink:NamedThing	saccular	A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance.		hp.json	sacular	http://purl.obolibrary.org/obo/PATO_0001987		value_slim
PATO:0001988	biolink:NamedThing	quadrangular	A shape quality inhering in a bearer by virtue of the bearer's having four angles and four sides.		hp.json		http://purl.obolibrary.org/obo/PATO_0001988		value_slim
HP:0032407	biolink:PhenotypicFeature	Bilateral perisylvian polymicrogyria	A type of perisylvian polymicrogyria that affects both sides of the brain.		hp.json		http://purl.obolibrary.org/obo/HP_0032407		
HP:0007439	biolink:PhenotypicFeature	Generalized keratosis follicularis		UMLS:C4024879	hp.json	Generalised keratosis follicularis	http://purl.obolibrary.org/obo/HP_0007439		
HP:0032406	biolink:PhenotypicFeature	Unilateral perisylvian polymicrogyria	A type of perisylvian polymicrogyria that largely affects one side of the brain.		hp.json		http://purl.obolibrary.org/obo/HP_0032406		
HP:0032409	biolink:PhenotypicFeature	Subcortical band heterotopia	A form of subcortical heterotopia with mislocalized gray matter within the white matter.It is defined as longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter. It is part of the lissencephaly spectrum.		hp.json		http://purl.obolibrary.org/obo/HP_0032409		
HP:0032408	biolink:PhenotypicFeature	Breast mass	A breast lump is any discrete mass in a breast noticed by the patient, significant other, or physician.		hp.json	Breast lump	http://purl.obolibrary.org/obo/HP_0032408		
HP:0032403	biolink:PhenotypicFeature	Asparaginuria	An increased concentration of asparagine in the urine.		hp.json	Increased level of asparagine in urine|Increased urine asparagine level	http://purl.obolibrary.org/obo/HP_0032403		
HP:0007436	biolink:PhenotypicFeature	Hair-nail ectodermal dysplasia		UMLS:C4024880	hp.json		http://purl.obolibrary.org/obo/HP_0007436		
HP:0007435	biolink:PhenotypicFeature	obsolete Diffuse palmoplantar keratoderma			hp.json		http://purl.obolibrary.org/obo/HP_0007435		
HP:0007438	biolink:PhenotypicFeature	Mottled pigmentation of the trunk and proximal extremities		UMLS:C1851551	hp.json		http://purl.obolibrary.org/obo/HP_0007438		
HP:0032405	biolink:PhenotypicFeature	Increased urinary phosphoserine level	An increased level of phosphoserine in the urine.		hp.json	Increased level of phosphoserine in urine	http://purl.obolibrary.org/obo/HP_0032405		
HP:0007437	biolink:PhenotypicFeature	Multiple cutaneous leiomyomas	The presence of multiple leiomyomas of the skin.	MSH:C535516|NCIT:C3157|UMLS:C1708350	hp.json		http://purl.obolibrary.org/obo/HP_0007437		
HP:0032404	biolink:PhenotypicFeature	Testicular mass	An abnormal bulge or lump in a testis. A testicular mass has a long differential diagnosis including testicular torsion, epididymitis, acute orchitis, strangulated hernia and testicular cancer.		hp.json		http://purl.obolibrary.org/obo/HP_0032404		
HP:0007432	biolink:PhenotypicFeature	Intermittent generalized erythematous papular rash		UMLS:C2749995	hp.json	Intermittent generalised erythematous papular rash	http://purl.obolibrary.org/obo/HP_0007432		
HP:0007431	biolink:PhenotypicFeature	Congenital ichthyosiform erythroderma	An ichthyosiform abnormality of the skin with congenital onset.	SNOMEDCT_US:254156001|MSH:D016113|SNOMEDCT_US:268282005|UMLS:C0079583	hp.json	Congenital ichthyosis|Ichthyosis, congenital	http://purl.obolibrary.org/obo/HP_0007431		
HP:0007434	biolink:PhenotypicFeature	Plaque-like facial hemangioma	Hemangioma is a benign tumor of the vascular endothelial cells. This term refers to facial hemangiomas that have a plaque-like morphology.	UMLS:C1847884	hp.json	Hemangioma, facial, plaque-like	http://purl.obolibrary.org/obo/HP_0007434		
HP:0007430	biolink:PhenotypicFeature	Generalized edema	Generalized abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.	SNOMEDCT_US:271808008|UMLS:C1850534	hp.json	Generalised oedema|Generalised tissue oedema|Generalized tissue edema	http://purl.obolibrary.org/obo/HP_0007430		
HP:0032410	biolink:PhenotypicFeature	Bilateral generalized polymicrogyria	Symmetric generalized polymicrogyria with no obvious gradient or region of maximal severity; may have abnormal high signal in white matter.		hp.json	Bilateral generalised polymicrogyria|Diffuse polymicrogyria	http://purl.obolibrary.org/obo/HP_0032410		
PATO:0001997	biolink:NamedThing	decreased amount	An amount which is relatively low.		hp.json	decreased|subnumerary|reduced|present in fewer numbers in organism|decreased number	http://purl.obolibrary.org/obo/PATO_0001997		value_slim
HP:0032412	biolink:PhenotypicFeature	Anterior predominant subcortical band heterotopia	Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible in the frontal and temporal lobes.		hp.json	Subcortical band heterotopia anterior predominant|Frontal subcortical band heterotopia	http://purl.obolibrary.org/obo/HP_0032412		
HP:0032411	biolink:PhenotypicFeature	Posterior predominant subcortical band heterotopia	Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the occipital cortex.		hp.json	Occipital subcortical band heterotopia|Subcortical band heterotopia posterior predominant	http://purl.obolibrary.org/obo/HP_0032411		
PATO:0001995	biolink:NamedThing	organismal quality	A quality that inheres in an entire organism or part of an organism.		hp.json		http://purl.obolibrary.org/obo/PATO_0001995		
PATO:0001999	biolink:NamedThing	lacks parts or has fewer parts of type	The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type.		hp.json	loss of	http://purl.obolibrary.org/obo/PATO_0001999		relational_slim
GO:0008152	biolink:BiologicalProcess	metabolic process	The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.	Wikipedia:Metabolism	hp.json	metabolism resulting in cell growth|metabolism|multicellular organism metabolic process|metabolic process resulting in cell growth|single-organism metabolic process	http://purl.obolibrary.org/obo/GO_0008152		goslim_chembl|goslim_metagenomics|gocheck_do_not_manually_annotate|goslim_pir|goslim_plant
HP:0032418	biolink:PhenotypicFeature	Abnormal HDL subfraction concentration	An abnormal concentration of an HDL subfraction, which can be determined by methods such as electrophoresis followed by densitometric determination of the areas under the peaks. Large HDL subfractions are defined as HDL1 (greater than 12 nm), HDL2b (9.7-12 nm), and HDL2a (8.8-9.69 nm). Small HDL subfractions are defined as HDL3a (8.2-8.79 nm), HDL3b (7.8-8.19 nm), and HDL3c (7.20-7.79 nm).		hp.json		http://purl.obolibrary.org/obo/HP_0032418		
HP:0007407	biolink:PhenotypicFeature	Excessive skin wrinkling on dorsum of hands and fingers		UMLS:C1837467	hp.json	Excessive skin wrinkling on back of hands and fingers	http://purl.obolibrary.org/obo/HP_0007407		
HP:0007406	biolink:PhenotypicFeature	Hyperpigmentation of eyelids		UMLS:C0854438|UMLS:C0155211|SNOMEDCT_US:41115008|UMLS:C4280440|MSH:C562400	hp.json	Dark eyelids|Brown eyelids|Pigmentation of eyelids	http://purl.obolibrary.org/obo/HP_0007406		
HP:0032417	biolink:PhenotypicFeature	Periglomerular fibrosis	Circumferential fibrosis in the interstitium surrounding Bowman's capsule	PMID:32866505	hp.json	Periglomerular fibrotic thickening	http://purl.obolibrary.org/obo/HP_0032417		
GO:0008150	biolink:BiologicalProcess	biological_process	A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.	Wikipedia:Biological_process	hp.json	single-organism process|physiological process|biological process|single organism process	http://purl.obolibrary.org/obo/GO_0008150		goslim_aspergillus|goslim_chembl|goslim_metagenomics|goslim_yeast|goslim_candida|goslim_generic|goslim_pombe|goslim_pir|goslim_plant
HP:0007409	biolink:PhenotypicFeature	obsolete Absence of subcutaneous fat over entire body except buttocks, hips, and thighs			hp.json		http://purl.obolibrary.org/obo/HP_0007409		
PR:P55284	biolink:Protein	cadherin-5 (mouse)	A cadherin-5 that is encoded in the genome of mouse.	UniProtKB:P55284	hp.json	mCDH5|Cdh5|VE-cadherin (mouse)|CD144 (mouse)|vascular endothelial cadherin (mouse)	http://purl.obolibrary.org/obo/PR_P55284		
HP:0032419	biolink:PhenotypicFeature	Abnormal HDL2a concentration	Any deviation from the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2A particle is defined as an HDL particle with a size of 8.80-9.69 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032419		
HP:0007408	biolink:PhenotypicFeature	Tegumentary leishmaniasis susceptibility	Increased susceptibility to infection by the protozan parasite of the genus Leishmania.	UMLS:C2748501	hp.json		http://purl.obolibrary.org/obo/HP_0007408		
HP:0032414	biolink:PhenotypicFeature	Hydroxylysinuria	The presence of an elevated amount of 5-hydroxylysine in the urine. This compound is a hydroxylated derivative of the amino acid lysine that is present in certain collagens.		hp.json		http://purl.obolibrary.org/obo/HP_0032414		
PATO:0001992	biolink:NamedThing	cellularity	An organismal quality inhering in a bearer by virtue of the bearer's consisting cells.		hp.json		http://purl.obolibrary.org/obo/PATO_0001992		scalar_slim|attribute_slim
HP:0007403	biolink:PhenotypicFeature	Hypertrophy of skin of soles		UMLS:C1867617	hp.json	Thick skin of soles	http://purl.obolibrary.org/obo/HP_0007403		
PATO:0001993	biolink:NamedThing	multicellular	A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell.		hp.json		http://purl.obolibrary.org/obo/PATO_0001993		value_slim
HP:0032413	biolink:PhenotypicFeature	Diffuse subcortical band heterotopia	Longitudinal bands of gray matter located deep to the cerebral cortex and separated from it by a thin layer of normal appearing white matter visible along the whole brain.		hp.json	Subcortical band heterotopia diffuse	http://purl.obolibrary.org/obo/HP_0032413		
HP:0007402	biolink:PhenotypicFeature	Areas of hypopigmentation and hyperpigmentation that do not follow Blaschko lines		UMLS:C4024886	hp.json		http://purl.obolibrary.org/obo/HP_0007402		
HP:0032416	biolink:PhenotypicFeature	Retinal microaneurysm	A localized dilation of microvasculature formed due to disruption of the internal elastic lamina of a retinal capillary blood vessel. The lesions present as small circular, red dots having distinct margins and are no larger than a blood vessel width at the disk margin. This expansion disturbs the normal flow pattern, changing shear force and pressure along the vessel. Shear force plays a key role in promoting the differentiation and proliferation of endothelial cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032416		
HP:0007404	biolink:PhenotypicFeature	Nonepidermolytic palmoplantar hyperkeratosis	Abnormal thickening of the skin on the palms and soles charactersized by hyperkeratosis of the stratum corneum with no evidence of epidermolysis characteristic of epidermolytic hyperkeratosis.	UMLS:C1833030|MSH:C563422	hp.json	Nonepidermolytic palmoplantar keratoderma	http://purl.obolibrary.org/obo/HP_0007404		
HP:0032415	biolink:PhenotypicFeature	Parasagittal parieto-occipital polymicrogyria	Polymicrogyria in parasagittal and mesial aspects of parieto-occipital cortex.		hp.json		http://purl.obolibrary.org/obo/HP_0032415		
GO:0035767	biolink:BiologicalProcess	endothelial cell chemotaxis	The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).		hp.json		http://purl.obolibrary.org/obo/GO_0035767		
HP:0007401	biolink:PhenotypicFeature	Macular atrophy	Well-demarcated area(s) of partial or complete depigmentation in the macula, reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss.	UMLS:C1288283|SNOMEDCT_US:238828009|MSH:D057088	hp.json		http://purl.obolibrary.org/obo/HP_0007401		
HP:0007400	biolink:PhenotypicFeature	Irregular hyperpigmentation		UMLS:C1860236	hp.json		http://purl.obolibrary.org/obo/HP_0007400		
HP:0032421	biolink:PhenotypicFeature	Decreased HDL2a concentration	A reduction below the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2A particle is defined as an HDL particle with a size of 8.80-9.69 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032421		
HP:0032420	biolink:PhenotypicFeature	Increased HDL2a concentration	An elevation above the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2A particle is defined as an HDL particle with a size of 8.80-9.69 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032420		
HP:0032423	biolink:PhenotypicFeature	Decreased HDL2b concentration	A reduction below the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032423		
HP:0032422	biolink:PhenotypicFeature	Abnormal HDL2b concentration	Any deviation from the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2B particle is defined as an HDL particle with a size of 9.7-12 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032422		
HP:0007418	biolink:PhenotypicFeature	Alopecia totalis	Loss of all scalp hair.	UMLS:C0263504|SNOMEDCT_US:19754005	hp.json	Total alopecia	http://purl.obolibrary.org/obo/HP_0007418		
HP:0032429	biolink:PhenotypicFeature	Decreased HDL3a concentration	A reduction below the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032429		
HP:0032428	biolink:PhenotypicFeature	Increased HDL3a concentration	An elevation above the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032428		
HP:0007417	biolink:PhenotypicFeature	Discoid lupus rash	Cutaneous lesion that develops as a dry, scaly, red patch that evolves to an indurated and hyperpigmented plaque with adherent scale. Scarring may result in central white patches (loss of pigmentation) and skin atrophy.	MSH:D008179|SNOMEDCT_US:238927000|SNOMEDCT_US:200938002|UMLS:C0024138	hp.json	Discoid lupus erythematosus	http://purl.obolibrary.org/obo/HP_0007417		
HP:0032425	biolink:PhenotypicFeature	Abnormal HDL3a concentration	Any deviation from the normal concentration of the HDL3a subfraction in the blood circulation. An HDL3a particle is defined as an HDL particle with a size of 8.2-8.79 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032425		
HP:0007414	biolink:PhenotypicFeature	Neonatal wrinkled skin of hands and feet		UMLS:C4024884	hp.json	Wrinkled skin of hands and feet in newborn	http://purl.obolibrary.org/obo/HP_0007414		
HP:0032424	biolink:PhenotypicFeature	Increased HDL2b concentration	An elevation above the normal concentration of the HDL2b subfraction in the blood circulation. An HDL2b particle is defined as an HDL particle with a size of 9.7-12 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032424		
HP:0007413	biolink:PhenotypicFeature	Nevus flammeus of the forehead	Naevus flammeus localised in the skin of the forehead.	UMLS:C1848850	hp.json	Port-wine stain on forehead	http://purl.obolibrary.org/obo/HP_0007413		
HP:0032427	biolink:PhenotypicFeature	Abnormal HDL3c concentration	Any deviation from the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032427		
HP:0032426	biolink:PhenotypicFeature	Abnormal HDL3b concentration	Any deviation from the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm.		hp.json		http://purl.obolibrary.org/obo/HP_0032426		
HP:0007410	biolink:PhenotypicFeature	Palmoplantar hyperhidrosis	An abnormally increased perspiration on palms and soles.	SNOMEDCT_US:403375001|UMLS:C1274743|MSH:C563185	hp.json	Hyperhidrosis of palms and soles|Excessive sweating of palms and soles	http://purl.obolibrary.org/obo/HP_0007410		
HP:0007412	biolink:PhenotypicFeature	Macular hyperpigmented dermopathy		UMLS:C4024885	hp.json		http://purl.obolibrary.org/obo/HP_0007412		
HP:0007411	biolink:PhenotypicFeature	Hypoplastic-absent sebaceous glands		UMLS:C1844617	hp.json		http://purl.obolibrary.org/obo/HP_0007411		
PATO:0001938	biolink:NamedThing	rhomboid	A spheroid quality inhering in a bearer by virtue of the bearer's being oval and a little angular in the middle.		hp.json		http://purl.obolibrary.org/obo/PATO_0001938		value_slim
HP:0007470	biolink:PhenotypicFeature	Periarticular subcutaneous nodules	Subcutaneous nodules that are located in the vicinity of joints.	UMLS:C3806306	hp.json		http://purl.obolibrary.org/obo/HP_0007470		
PATO:0001937	biolink:NamedThing	spatulate	A shape quality inhering in a bearer by virtue of the bearer's being oblong, with the lower end very much attenuated.		hp.json	spathulate	http://purl.obolibrary.org/obo/PATO_0001937		value_slim
HP:0007469	biolink:PhenotypicFeature	Palmoplantar cutis gyrata	Cutis gyrata of palms and soles.	UMLS:C1851797	hp.json	Cutis gyrata of palms and soles	http://purl.obolibrary.org/obo/HP_0007469		
HP:0007468	biolink:PhenotypicFeature	Perifollicular hyperkeratosis	Increased amount of keratin (visible as white scales) surrounding hair follicles.	UMLS:C4024867	hp.json		http://purl.obolibrary.org/obo/HP_0007468		hposlim_core
HP:0007465	biolink:PhenotypicFeature	Honeycomb palmoplantar hyperkeratosis	Abnormal thickening of the skin on the palms and soles with an honeycomb pattern.	UMLS:C1866032	hp.json		http://purl.obolibrary.org/obo/HP_0007465		
HP:0007464	biolink:PhenotypicFeature	Sparse facial hair	Reduced number or density of facial hair.	UMLS:C2017869	hp.json	Sparse facial hair	http://purl.obolibrary.org/obo/HP_0007464		
HP:0007466	biolink:PhenotypicFeature	Midfrontal capillary hemangioma		UMLS:C1859339	hp.json		http://purl.obolibrary.org/obo/HP_0007466		
HP:0007461	biolink:PhenotypicFeature	Hemangiomatosis		SNOMEDCT_US:254785001|UMLS:C1384590|SNOMEDCT_US:47669001	hp.json		http://purl.obolibrary.org/obo/HP_0007461		
HP:0007460	biolink:PhenotypicFeature	Autoamputation of digits		UMLS:C1852289	hp.json		http://purl.obolibrary.org/obo/HP_0007460		
HP:0007462	biolink:PhenotypicFeature	Bitot spots of the conjunctiva	Keratinization of the bulbar conjunctiva near the limbus (corneoscleral junction), resulting in a raised spot.	UMLS:C0423178|UMLS:C4024868|SNOMEDCT_US:246871006	hp.json	Bitot's spots	http://purl.obolibrary.org/obo/HP_0007462		
HP:0007481	biolink:PhenotypicFeature	Hyperpigmented nevi		UMLS:C0746889	hp.json		http://purl.obolibrary.org/obo/HP_0007481		
HP:0007480	biolink:PhenotypicFeature	Decreased sweating due to autonomic dysfunction		UMLS:C1868527	hp.json		http://purl.obolibrary.org/obo/HP_0007480		
PATO:0001948	biolink:NamedThing	furrowed	A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by two or more parallel channels.		hp.json	fluted	http://purl.obolibrary.org/obo/PATO_0001948		value_slim
GO:0035735	biolink:BiologicalProcess	intraciliary transport involved in cilium assembly	The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.	Reactome:R-HSA-5620924.2	hp.json	intraflagellar transport involved in cilium morphogenesis|intraflagellar transport|intraciliary transport involved in cilium morphogenesis	http://purl.obolibrary.org/obo/GO_0035735		
GO:0035736	biolink:BiologicalProcess	cell proliferation involved in compound eye morphogenesis	The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_0035736		
PATO:0001940	biolink:NamedThing	gigantic	A size quality inhering in a bearer by virtue of the bearer's being many folds greater relative to the normal average.		hp.json	giant	http://purl.obolibrary.org/obo/PATO_0001940		value_slim
GO:0008134	biolink:MolecularActivity	transcription factor binding	Binding to a transcription factor, a protein required to initiate or regulate transcription.		hp.json	TF binding|transcription regulator binding	http://purl.obolibrary.org/obo/GO_0008134		gocheck_do_not_annotate|goslim_drosophila|goslim_chembl|goslim_metagenomics|goslim_yeast|goslim_agr
HP:0007479	biolink:PhenotypicFeature	Congenital nonbullous ichthyosiform erythroderma	The term collodion baby applies to newborns who appear to have an extra layer of skin (known as a collodion membrane) that has a collodion-like quality. It is a descriptive term, not a specific diagnosis or disorder (as such, it is a syndrome). Affected babies are born in a collodion membrane, a shiny waxy outer layer to the skin. This is shed 10-14 days after birth, revealing the main symptom of the disease, extensive scaling of the skin caused by hyperkeratosis. With increasing age, the scaling tends to be concentrated around joints in areas such as the groin, the armpits, the inside of the elbow and the neck. The scales often tile the skin and may resemble fish scales.	SNOMEDCT_US:268245001|SNOMEDCT_US:267372009|UMLS:C0079154|SNOMEDCT_US:205550003|MSH:D017490	hp.json	Ichthyosis lammellaris|Nonbullous congenital ichthyosiform erythroderma|Collodion baby|Nonbullous congenital ichthyosis|Congenital lamellar ichthyosis|Congenital non-bullous ichthyosis|Ichthyosis, congenital, nonblistering	http://purl.obolibrary.org/obo/HP_0007479		
HP:0007476	biolink:PhenotypicFeature	Anhidrotic ectodermal dysplasia		MSH:D004476|SNOMEDCT_US:7731005|UMLS:C1706004	hp.json		http://purl.obolibrary.org/obo/HP_0007476		
HP:0007475	biolink:PhenotypicFeature	Congenital bullous ichthyosiform erythroderma	An ichthyosiform abnormality of the skin that presents at birth or shortly thereafter with generalized erythema, blistering, erosions, and peeling. In the subsequent months, erythema and blistering improves but patients go on to develop hyperkeratotic scaling that is especially prominent along the joint flexures, neck, hands and feet.	SNOMEDCT_US:239071005|MSH:D017488|SNOMEDCT_US:254167000|UMLS:C0079153	hp.json	Bullous congenital ichthyosiform erythroderma|Epidermolytic hyperkeratosis	http://purl.obolibrary.org/obo/HP_0007475		
HP:0007477	biolink:PhenotypicFeature	Abnormal dermatoglyphics	An abnormality of dermatoglyphs (fingerprints), which are present on fingers, palms, toes, and soles.	UMLS:C0432333|SNOMEDCT_US:83145004	hp.json	Dermatoglyphic abnormalities|Abnormal fingerprints	http://purl.obolibrary.org/obo/HP_0007477		hposlim_core
HP:0007471	biolink:PhenotypicFeature	Axillary and groin hyperpigmentation and hypopigmentation		UMLS:C4024866	hp.json		http://purl.obolibrary.org/obo/HP_0007471		
HP:0007473	biolink:PhenotypicFeature	Crusting erythematous dermatitis		UMLS:C1868496	hp.json		http://purl.obolibrary.org/obo/HP_0007473		
PATO:0001958	biolink:NamedThing	increased variability of size	A variability of size which is relatively high.		hp.json	high variability of size	http://purl.obolibrary.org/obo/PATO_0001958		value_slim
GO:0008104	biolink:BiologicalProcess	protein localization	Any process in which a protein is transported to, or maintained in, a specific location.		hp.json	asymmetric protein localization|establishment and maintenance of protein localization|protein localisation|establishment and maintenance of asymmetric protein localization|asymmetric protein localisation	http://purl.obolibrary.org/obo/GO_0008104		goslim_drosophila
PATO:0001956	biolink:NamedThing	variability of size	A variability quality inhering in a bearer by virtue of whether the bearer exhibits size variation or change.		hp.json		http://purl.obolibrary.org/obo/PATO_0001956		attribute_slim
PATO:0001957	biolink:NamedThing	decreased variability of size	A variability of size which is relatively low.		hp.json	low variability of size	http://purl.obolibrary.org/obo/PATO_0001957		value_slim
PATO:0001955	biolink:NamedThing	cuneate	A shape quality inhering in a bearer by virtue of the bearer's being narrowly triangular, wider at the apex and tapering toward the base.		hp.json	wedge-shaped	http://purl.obolibrary.org/obo/PATO_0001955		value_slim
CHEBI:131619	biolink:ChemicalSubstance	C27-steroid	A steroid compound with a structure based on a 27-carbon (cholestane) skeleton.		hp.json	C27-steroids	http://purl.obolibrary.org/obo/CHEBI_131619		3_STAR
HP:0007447	biolink:PhenotypicFeature	Diffuse palmoplantar hyperkeratosis	Diffuse abnormal thickening of the skin on the palms and soles.	UMLS:C4021575|MSH:D015776	hp.json	Hyperkeratosis, diffuse palmoplantar|Diffuse palmoplantar keratoderma	http://purl.obolibrary.org/obo/HP_0007447		
HP:0007446	biolink:PhenotypicFeature	Palmoplantar blistering	A type of blistering that affects the skin of the palms of the hands and the soles of the feet.	UMLS:C4024876	hp.json		http://purl.obolibrary.org/obo/HP_0007446		
HP:0007449	biolink:PhenotypicFeature	Confetti-like hypopigmented macules		UMLS:C1851705	hp.json		http://purl.obolibrary.org/obo/HP_0007449		
HP:0007448	biolink:PhenotypicFeature	Hyperkeratosis over edematous areas		UMLS:C1835253	hp.json		http://purl.obolibrary.org/obo/HP_0007448		
HP:0007443	biolink:PhenotypicFeature	Partial albinism	Absence of melanin pigment in various areas, which is found at birth and is permanent. The lesions are known as leucoderma and are often found on the face, trunk, or limbs.	SNOMEDCT_US:6479008|UMLS:C0080024|MSH:D016116|SNOMEDCT_US:718122005	hp.json	Partial absent skin pigmentation|Congenital partial albinism on face, trunk, or limbs|Congenital partial leucoderma	http://purl.obolibrary.org/obo/HP_0007443		
HP:0007441	biolink:PhenotypicFeature	Hyperpigmented/hypopigmented macules		UMLS:C4024877	hp.json		http://purl.obolibrary.org/obo/HP_0007441		
HP:0007440	biolink:PhenotypicFeature	Generalized hyperpigmentation		UMLS:C4024878	hp.json	Generalised hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007440		
HP:0007458	biolink:PhenotypicFeature	Focal hyperextensible skin		UMLS:C4024870	hp.json		http://purl.obolibrary.org/obo/HP_0007458		
HP:0007457	biolink:PhenotypicFeature	Prominent veins on trunk	Prominent thoracic and abdominal veins.	UMLS:C4024871	hp.json		http://purl.obolibrary.org/obo/HP_0007457		
CHEBI:131621	biolink:ChemicalSubstance	C19-steroid	A steroid compound with a structure based on a 19-carbon (androstane) skeleton.		hp.json	C19-steroids	http://purl.obolibrary.org/obo/CHEBI_131621		3_STAR
HP:0007459	biolink:PhenotypicFeature	Generalized anhidrosis		UMLS:C4024869	hp.json	Generalized anhydrosis|Generalised inability to sweat|Generalized inability to sweat|Generalised anhidrosis|Generalised anhydrosis	http://purl.obolibrary.org/obo/HP_0007459		
HP:0007453	biolink:PhenotypicFeature	Flexural lichenification	Lichenification affecting primarily flexural areas of the skin.	UMLS:C4024873	hp.json		http://purl.obolibrary.org/obo/HP_0007453		
HP:0007456	biolink:PhenotypicFeature	Progressive reticulate hyperpigmentation		UMLS:C4024872	hp.json		http://purl.obolibrary.org/obo/HP_0007456		
HP:0007455	biolink:PhenotypicFeature	Adermatoglyphia		UMLS:C1852150|MSH:C565010	hp.json		http://purl.obolibrary.org/obo/HP_0007455		
HP:0007450	biolink:PhenotypicFeature	Increased groin pigmentation with raindrop depigmentation		UMLS:C4024875	hp.json		http://purl.obolibrary.org/obo/HP_0007450		
HP:0007452	biolink:PhenotypicFeature	Midface capillary hemangioma		UMLS:C1849377	hp.json	Midfacial capillary hemangioma	http://purl.obolibrary.org/obo/HP_0007452		
HP:0007451	biolink:PhenotypicFeature	Ipsilateral lack of facial sweating	Inability to sweat on the same side of the face that is affected by ptosis and miosis. This is a feature of Horner syndrome.	UMLS:C4024874	hp.json		http://purl.obolibrary.org/obo/HP_0007451		
GO:0072698	biolink:BiologicalProcess	protein localization to microtubule cytoskeleton	A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton.		hp.json	protein localisation to microtubule cytoskeleton	http://purl.obolibrary.org/obo/GO_0072698		
GO:0072697	biolink:BiologicalProcess	protein localization to cell cortex	A process in which a protein is transported to, or maintained in, the cell cortex.		hp.json	protein localisation to cell cortex	http://purl.obolibrary.org/obo/GO_0072697		
GO:0045087	biolink:BiologicalProcess	innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.	Wikipedia:Innate_immune_system	hp.json	nonspecific immune response|innate immunity	http://purl.obolibrary.org/obo/GO_0045087		
PATO:0001908	biolink:NamedThing	multinucleate	A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus.		hp.json		http://purl.obolibrary.org/obo/PATO_0001908		value_slim|mpath_slim
GO:0045088	biolink:BiologicalProcess	regulation of innate immune response	Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.		hp.json		http://purl.obolibrary.org/obo/GO_0045088		
GO:0045089	biolink:BiologicalProcess	positive regulation of innate immune response	Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.		hp.json	stimulation of innate immune response|up-regulation of innate immune response|upregulation of innate immune response|up regulation of innate immune response	http://purl.obolibrary.org/obo/GO_0045089		
UBERON:0037191	biolink:AnatomicalEntity	wall of membranous labyrinth		FMA:79837	hp.json	membranous labyrinth wall	http://purl.obolibrary.org/obo/UBERON_0037191		
GO:0045095	biolink:NamedThing	keratin filament			hp.json		http://purl.obolibrary.org/obo/GO_0045095		
GO:0070051	biolink:MolecularActivity	fibrinogen binding	Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade.		hp.json		http://purl.obolibrary.org/obo/GO_0070051		
OBO:MAXO_0000003	biolink:NamedThing	diagnostic procedure	Any procedure or test to diagnose a disease or disorder.	NCIT:C18020|OGMS:0000104	hp.json	diagnostic technique procedure|diagnostic testing	http://purl.obolibrary.org/obo/MAXO_0000003		
GO:0070050	biolink:BiologicalProcess	neuron cellular homeostasis	The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state.		hp.json	neuron maintenance	http://purl.obolibrary.org/obo/GO_0070050		
UBERON:0013191	biolink:AnatomicalEntity	ovarian cortex	The layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles.	EMAPA:37927|FMA:18613|NCIT:C33243|UMLS:C0227878	hp.json	cortex ovarii (zona parenchymatosa)|cortex of ovary	http://purl.obolibrary.org/obo/UBERON_0013191		pheno_slim|human_reference_atlas
UBERON:0013192	biolink:AnatomicalEntity	ovarian medulla	Highly vascular stroma found in the center of the ovary that forms from embryonic mesenchyme and contains blood vessels, lymphatic vessels, and nerves; this stroma forms the tissue of the hilum by which the ovarian ligament is attached, and through which the blood vessels enter; it does not contain any ovarian follicles.	EMAPA:37928|NCIT:C33245|UMLS:C0227879|FMA:18616	hp.json	medulla of ovary|medulla ovarii (zona vasculosa)|zona vasculosa of Waldeyer	http://purl.obolibrary.org/obo/UBERON_0013192		pheno_slim
PATO:0001919	biolink:NamedThing	mislocalised dorsally	A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the back or upper surface of an organism.		hp.json		http://purl.obolibrary.org/obo/PATO_0001919		value_slim
PATO:0001910	biolink:NamedThing	folded	A surface feature shape quality inhering in a bearer by virtue of the bearer's one part being layered over another connected part.		hp.json		http://purl.obolibrary.org/obo/PATO_0001910		value_slim
OBO:MAXO_0000006	biolink:NamedThing	clinical laboratory procedure	Any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting for diagnosis, treatment, or therapy.	NCIT:C25294	hp.json	clinical testing|clinical lab testing|clinical laboratory testing|lab testing	http://purl.obolibrary.org/obo/MAXO_0000006		
OBO:MAXO_0000005	biolink:NamedThing	clinical imaging procedure	Any technology or method that aids in the visualization of any biological process, cell, tissue or organ for use in screening, diagnosis, surgical procedures or therapy.	NCIT:C17369	hp.json	imaging procedure|medical imaging|imaging technique|therapeutic imaging procedure|therapeutic imaging technique	http://purl.obolibrary.org/obo/MAXO_0000005		
PATO:0001928	biolink:NamedThing	blistered	A texture quality inhering in a bearer by virtue of a local accumulation of fluid underneath the surface of the bearer.		hp.json	blistering	http://purl.obolibrary.org/obo/PATO_0001928		value_slim|mpath_slim
PATO:0001925	biolink:NamedThing	surface feature shape	A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell.		hp.json		http://purl.obolibrary.org/obo/PATO_0001925		attribute_slim
PATO:0001923	biolink:NamedThing	mislocalised laterally	A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the side of an organism.		hp.json		http://purl.obolibrary.org/obo/PATO_0001923		value_slim
PATO:0001921	biolink:NamedThing	mislocalised anteriorly	A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the front of an organism.		hp.json		http://purl.obolibrary.org/obo/PATO_0001921		value_slim
PATO:0001922	biolink:NamedThing	mislocalised posteriorly	A positional quality inhering in a bearer by virtue of the bearer's being positioned towards the rear of an organism.		hp.json		http://purl.obolibrary.org/obo/PATO_0001922		value_slim
GO:0033059	biolink:BiologicalProcess	cellular pigmentation	The deposition or aggregation of coloring matter in a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0033059		
UBERON:0037144	biolink:AnatomicalEntity	wall of heart	Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees.	FMA:7274	hp.json	cardiac wall	http://purl.obolibrary.org/obo/UBERON_0037144		
GO:0008089	biolink:BiologicalProcess	anterograde axonal transport	The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.		hp.json	anterograde axon cargo transport	http://purl.obolibrary.org/obo/GO_0008089		goslim_synapse
GO:0008088	biolink:BiologicalProcess	axo-dendritic transport	The directed movement of organelles or molecules along microtubules in neuron projections.	Wikipedia:Axoplasmic_transport	hp.json	axon cargo transport|axoplasmic transport|axonal transport	http://purl.obolibrary.org/obo/GO_0008088		goslim_synapse
GO:0008092	biolink:MolecularActivity	cytoskeletal protein binding	Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).		hp.json		http://purl.obolibrary.org/obo/GO_0008092		goslim_flybase_ribbon|goslim_drosophila|goslim_chembl|goslim_mouse|goslim_agr|goslim_generic|goslim_yeast
GO:0008090	biolink:BiologicalProcess	retrograde axonal transport	The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.		hp.json	retrograde axon cargo transport	http://purl.obolibrary.org/obo/GO_0008090		goslim_synapse
GO:0033048	biolink:BiologicalProcess	negative regulation of mitotic sister chromatid segregation	Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.		hp.json		http://purl.obolibrary.org/obo/GO_0033048		
GO:0033047	biolink:BiologicalProcess	regulation of mitotic sister chromatid segregation	Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.		hp.json		http://purl.obolibrary.org/obo/GO_0033047		
GO:0033046	biolink:BiologicalProcess	negative regulation of sister chromatid segregation	Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.		hp.json		http://purl.obolibrary.org/obo/GO_0033046		
GO:0033045	biolink:BiologicalProcess	regulation of sister chromatid segregation	Any process that modulates the frequency, rate or extent of sister chromatid segregation.		hp.json		http://purl.obolibrary.org/obo/GO_0033045		
GO:0033044	biolink:BiologicalProcess	regulation of chromosome organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.		hp.json	regulation of chromosome organisation|regulation of chromosome organization and biogenesis	http://purl.obolibrary.org/obo/GO_0033044		
GO:0033043	biolink:BiologicalProcess	regulation of organelle organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.		hp.json	regulation of organelle organization and biogenesis|regulation of organelle organisation	http://purl.obolibrary.org/obo/GO_0033043		goslim_yeast
GO:0070062	biolink:CellularComponent	extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.		hp.json	exosome|extracellular vesicular exosome	http://purl.obolibrary.org/obo/GO_0070062		
GO:0033031	biolink:BiologicalProcess	positive regulation of neutrophil apoptotic process	Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.		hp.json	activation of neutrophil apoptosis|up-regulation of neutrophil apoptosis|positive regulation of neutrophil apoptosis|upregulation of neutrophil apoptosis|up regulation of neutrophil apoptosis|stimulation of neutrophil apoptosis	http://purl.obolibrary.org/obo/GO_0033031		
GO:0033030	biolink:BiologicalProcess	negative regulation of neutrophil apoptotic process	Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.		hp.json	downregulation of neutrophil apoptosis|negative regulation of neutrophil apoptosis|down regulation of neutrophil apoptosis|inhibition of neutrophil apoptosis|down-regulation of neutrophil apoptosis	http://purl.obolibrary.org/obo/GO_0033030		
GO:0033037	biolink:BiologicalProcess	polysaccharide localization	Any process in which a polysaccharide is transported to, or maintained in, a specific location.		hp.json	polysaccharide localisation	http://purl.obolibrary.org/obo/GO_0033037		
GO:0033036	biolink:BiologicalProcess	macromolecule localization	Any process in which a macromolecule is transported to, or maintained in, a specific location.		hp.json	macromolecule localisation	http://purl.obolibrary.org/obo/GO_0033036		goslim_flybase_ribbon
GO:0033034	biolink:BiologicalProcess	positive regulation of myeloid cell apoptotic process	Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.		hp.json	up regulation of myeloid cell apoptosis|stimulation of myeloid cell apoptosis|up-regulation of myeloid cell apoptosis|activation of myeloid cell apoptosis|positive regulation of myeloid cell apoptosis|upregulation of myeloid cell apoptosis	http://purl.obolibrary.org/obo/GO_0033034		
GO:0033033	biolink:BiologicalProcess	negative regulation of myeloid cell apoptotic process	Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.		hp.json	downregulation of myeloid cell apoptosis|negative regulation of myeloid cell apoptosis|down regulation of myeloid cell apoptosis|inhibition of myeloid cell apoptosis|down-regulation of myeloid cell apoptosis	http://purl.obolibrary.org/obo/GO_0033033		
GO:0033032	biolink:BiologicalProcess	regulation of myeloid cell apoptotic process	Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process.		hp.json	regulation of myeloid cell apoptosis	http://purl.obolibrary.org/obo/GO_0033032		
GO:0070093	biolink:BiologicalProcess	negative regulation of glucagon secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of glucagon.		hp.json	down-regulation of glucagon secretion|downregulation of glucagon secretion|down regulation of glucagon secretion|inhibition of glucagon secretion	http://purl.obolibrary.org/obo/GO_0070093		
GO:0070094	biolink:BiologicalProcess	positive regulation of glucagon secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.		hp.json	upregulation of glucagon secretion|stimulation of glucagon secretion|up regulation of glucagon secretion|activation of glucagon secretion|up-regulation of glucagon secretion	http://purl.obolibrary.org/obo/GO_0070094		
GO:0070091	biolink:BiologicalProcess	glucagon secretion	The regulated release of glucagon from secretory granules in the A (alpha) cells of the pancreas (islets of Langerhans).		hp.json		http://purl.obolibrary.org/obo/GO_0070091		
GO:0070092	biolink:BiologicalProcess	regulation of glucagon secretion	Any process that modulates the frequency, rate or extent of the regulated release of glucagon.		hp.json		http://purl.obolibrary.org/obo/GO_0070092		
GO:0033029	biolink:BiologicalProcess	regulation of neutrophil apoptotic process	Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process.		hp.json	regulation of neutrophil apoptosis	http://purl.obolibrary.org/obo/GO_0033029		
GO:0008066	biolink:MolecularActivity	glutamate receptor activity	Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.		hp.json		http://purl.obolibrary.org/obo/GO_0008066		
NCBITaxon:33317	biolink:OrganismalEntity	Protostomia		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_33317		
GO:0033028	biolink:BiologicalProcess	myeloid cell apoptotic process	Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.		hp.json	myeloid cell apoptosis|apoptosis of myeloid cells	http://purl.obolibrary.org/obo/GO_0033028		
GO:0070085	biolink:BiologicalProcess	glycosylation	The covalent attachment and further modification of carbohydrate residues to a substrate molecule.	Wikipedia:Glycosylation	hp.json		http://purl.obolibrary.org/obo/GO_0070085		
GO:0008078	biolink:BiologicalProcess	mesodermal cell migration	The orderly movement of mesodermal cells from one site to another.		hp.json	mesoderm cell migration	http://purl.obolibrary.org/obo/GO_0008078		
HGNC:8582	biolink:Gene	PAH (human)	A protein coding gene PAH in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8582		
GO:0033014	biolink:BiologicalProcess	tetrapyrrole biosynthetic process	The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.		hp.json	tetrapyrrole anabolism|tetrapyrrole synthesis|tetrapyrrole biosynthesis|tetrapyrrole formation	http://purl.obolibrary.org/obo/GO_0033014		
GO:0033013	biolink:BiologicalProcess	tetrapyrrole metabolic process	The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.		hp.json	tetrapyrrole metabolism	http://purl.obolibrary.org/obo/GO_0033013		prokaryote_subset|goslim_pombe
UBERON:0015791	biolink:AnatomicalEntity	digit connective tissue	A portion of connective tissue that is part of a digit.	EMAPA:37290|MA:0003123	hp.json		http://purl.obolibrary.org/obo/UBERON_0015791		
UBERON:0015790	biolink:AnatomicalEntity	autopod skin	A zone of skin that is part of a autopod region.	EMAPA:32723|MA:0003120	hp.json	paw skin	http://purl.obolibrary.org/obo/UBERON_0015790		
UBERON:0013136	biolink:AnatomicalEntity	vein of lip	A vein that drains a lip.	SCTID:367664002	hp.json	lip vein|labial vein|vena labialis|labial vein of face	http://purl.obolibrary.org/obo/UBERON_0013136		
CHEBI:36508	biolink:ChemicalSubstance	glycotriaosylceramide			hp.json		http://purl.obolibrary.org/obo/CHEBI_36508		1_STAR
UBERON:0013139	biolink:AnatomicalEntity	ligament of liver	A nonskeletal ligament that is part of a liver.	FMA:15820|NCIT:C32997|UMLS:C0230238	hp.json	liver ligament|hepatic ligament	http://purl.obolibrary.org/obo/UBERON_0013139		
UBERON:0013135	biolink:AnatomicalEntity	interdental plate	The interdental plate refers to the bone-filled mesial-distal region between the teeth.		hp.json		http://purl.obolibrary.org/obo/UBERON_0013135		
UBERON:0015796	biolink:AnatomicalEntity	liver blood vessel	A blood vessel that is part of a liver.	MA:0003137|EMAPA:35498	hp.json	hepatic blood vessel	http://purl.obolibrary.org/obo/UBERON_0015796		
UBERON:0001152	biolink:AnatomicalEntity	cystic duct	The tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct.	MA:0000355|NCIT:C32421|EHDAA2:0000333|FMA:14539|EHDAA:3045|ZFA:0005166|OpenCyc:Mx4rveBeC5wpEbGdrcN5Y29ycA|TAO:0005166|GAID:290|VHOG:0000213|galen:CysticDuct|EMAPA:16841|MESH:D003549|UMLS:C0010672	hp.json	ductus cysticus	http://purl.obolibrary.org/obo/UBERON_0001152		vertebrate_core|pheno_slim|uberon_slim
GO:0060632	biolink:BiologicalProcess	regulation of microtubule-based movement	Any process that modulates the rate, frequency, or extent of microtubule-based movement, the movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.		hp.json		http://purl.obolibrary.org/obo/GO_0060632		
PR:000010379	biolink:Protein	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	A protein that is a translation product of the human MGAT2 gene or a 1:1 ortholog thereof.		hp.json	N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II|GNT-II|mannoside acetylglucosaminyltransferase 2|beta-1,2-N-acetylglucosaminyltransferase II|GlcNAc-T II|MGAT2	http://purl.obolibrary.org/obo/PR_000010379		
UBERON:0001158	biolink:AnatomicalEntity	descending colon	The portion of the colon between the left colic flexure and the sigmoid colon at the pelvic brim; the portion of the descending colon lying in the left iliac fossa is sometimes called the iliac colon.	EFO:0000845|EMAPA:35285|MA:0001542|MAT:0000313|CALOHA:TS-2010|NCIT:C12268|UMLS:C0227389|MESH:D044683|galen:DescendingColon|MIAA:0000313|OpenCyc:Mx4rwHsNhpwpEbGdrcN5Y29ycA|BTO:0000641|FMA:14547	hp.json	colon descendens	http://purl.obolibrary.org/obo/UBERON_0001158		uberon_slim|efo_slim|human_reference_atlas
UBERON:0001159	biolink:AnatomicalEntity	sigmoid colon	The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity.	galen:SigmoidColon|EFO:0000846|MAT:0000314|CALOHA:TS-2044|Wikipedia:Sigmoid_colon|BTO:0000645|SCTID:362166007|EMAPA:36391|MIAA:0000314|NCIT:C33550|MESH:D012809|UMLS:C0682612|FMA:14548|NCIT:C12384|UMLS:C0227391|OpenCyc:Mx4rwHX_-5wpEbGdrcN5Y29ycA	hp.json	sigmoid flexure|sigmoid colon|colon sigmoideum|colon sigmoideum|pelvic colon	http://purl.obolibrary.org/obo/UBERON_0001159		uberon_slim|human_reference_atlas|efo_slim
UBERON:0001155	biolink:AnatomicalEntity	colon	A portion of the large intestine before it becomes the rectum. In mammals, the colon is the most part of the large intestine, excluding the vermiform appendix, the rectum and the anal canal.	MA:0000335|MAT:0000526|XAO:0000243|MESH:D003106|AAO:0010400|VHOG:0000648|UMLS:C0009368|ZFA:0000706|EV:0100079|EMAPA:18939|BTO:0000269|GAID:309|TAO:0000706|SCTID:302508007|OpenCyc:Mx4rvgLEM5wpEbGdrcN5Y29ycA|Wikipedia:Colon_(anatomy)|MAP:0000001|NCIT:C12382|EFO:0000361|CALOHA:TS-0158|FMA:14543|galen:Colon	hp.json	posterior intestine|large bowel|hindgut	http://purl.obolibrary.org/obo/UBERON_0001155		vertebrate_core|pheno_slim|efo_slim|uberon_slim
CHEBI:24533	biolink:ChemicalSubstance	heterodetic cyclic peptide	A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.		hp.json	peptido ciclico heterodetico|heterodetic cyclic peptides|heterodetic cyclic peptide|peptide cyclique heterodetique	http://purl.obolibrary.org/obo/CHEBI_24533		3_STAR
CHEBI:24532	biolink:ChemicalSubstance	organic heterocyclic compound	A cyclic compound having as ring members atoms of carbon and at least of one other element.		hp.json	organic heterocyclic compounds|organic heterocycle	http://purl.obolibrary.org/obo/CHEBI_24532		3_STAR
GO:1901738	biolink:BiologicalProcess	regulation of vitamin A metabolic process	Any process that modulates the frequency, rate or extent of vitamin A metabolic process.		hp.json	regulation of vitamin A metabolism	http://purl.obolibrary.org/obo/GO_1901738		
UBERON:0001139	biolink:AnatomicalEntity	common iliac vein	A vein that drains the pelvis and lower limbs into the inferior vena cava.	galen:CommonIliacVein|UMLS:C0226758|FMA:14333|EMAPA:17874|NCIT:C32359|OpenCyc:Mx4rv92CGZwpEbGdrcN5Y29ycA|MA:0002143	hp.json	common iliac venous tree|vena iliaca communis	http://purl.obolibrary.org/obo/UBERON_0001139		human_reference_atlas|uberon_slim
UBERON:0015788	biolink:AnatomicalEntity	olfactory apparatus chamber	An anatomical chamber that is part of the olfactory apparatus, consisting of cavity walls (nasal epithelium and mucosal layers) and the space bounded anteriorly by the nares and posteriorly by the choanae, when these structures are present.	FMA:265136	hp.json		http://purl.obolibrary.org/obo/UBERON_0015788		
UBERON:0013126	biolink:AnatomicalEntity	vein of abdomen	A vein that is part of a abdomen.	SCTID:281473003	hp.json	abdominal vein	http://purl.obolibrary.org/obo/UBERON_0013126		grouping_class
UBERON:0015787	biolink:AnatomicalEntity	upper respiratory conduit	Any anatomical conduit which is part of the upper respiratory tract.	FMA:265132	hp.json	respiratory conduit	http://purl.obolibrary.org/obo/UBERON_0015787		
UBERON:0015789	biolink:AnatomicalEntity	cranial or facial muscle		MA:0000579|EMAPA:25133	hp.json	craniofacial muscle|cranial/facial muscle|cranial-facial muscle|cranio-facial muscle	http://purl.obolibrary.org/obo/UBERON_0015789		grouping_class
GO:1901731	biolink:BiologicalProcess	positive regulation of platelet aggregation	Any process that activates or increases the frequency, rate or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.		hp.json	up-regulation of thrombocyte aggregation|positive regulation of blood platelet aggregation|up regulation of thrombocyte aggregation|up regulation of blood platelet aggregation|upregulation of platelet aggregation|positive regulation of thrombocyte aggregation|up-regulation of blood platelet aggregation|activation of blood platelet aggregation|up regulation of platelet aggregation|upregulation of thrombocyte aggregation|activation of thrombocyte aggregation|up-regulation of platelet aggregation|activation of platelet aggregation|upregulation of blood platelet aggregation	http://purl.obolibrary.org/obo/GO_1901731		
UBERON:0013121	biolink:AnatomicalEntity	proximal epiphysis of phalanx of pes		FMA:32888	hp.json	basis phalangis (pedis)|proximal epiphysis of phalanx of toe|base of phalanx of foot|basis phalangis pedis|basal epiphysis of phalanx of foot	http://purl.obolibrary.org/obo/UBERON_0013121		
UBERON:0015783	biolink:AnatomicalEntity	smooth muscle layer in fatty layer of subcutaneous tissue	A smooth muscle tissue that is part of a hypodermis.	FMA:77862	hp.json	muscle layer in fatty layer of subcutaneous tissue|stratum musculosum panniculi adiposi telae subcutaneae	http://purl.obolibrary.org/obo/UBERON_0015783		
UBERON:0013122	biolink:AnatomicalEntity	distal epiphysis of phalanx of pes		FMA:32890	hp.json	ungual tuberosity of distal phalanx of toe|caput phalangis pedis|distal epiphysis of phalanx of toe|distal end of phalanx of foot|caput phalangis (pedis)|head of phalanx of foot	http://purl.obolibrary.org/obo/UBERON_0013122		
UBERON:0013124	biolink:AnatomicalEntity	left posterior cardinal vein	A posterior cardinal vein that is in_the_left_side_of a multicellular organism.	FMA:70316|EHDAA2:0001486	hp.json	left postcardinal vein|posterior cardinal vein left	http://purl.obolibrary.org/obo/UBERON_0013124		
UBERON:0001141	biolink:AnatomicalEntity	right renal vein	A renal vein that drains the right kidney.	EMAPA:37381|NCIT:C52695|MA:0002212|UMLS:C0508000|OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvdUXKJwpEbGdrcN5Y29ycA|FMA:14335	hp.json		http://purl.obolibrary.org/obo/UBERON_0001141		pheno_slim|human_reference_atlas
UBERON:0001140	biolink:AnatomicalEntity	renal vein	Either of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava.	EHDAA2:0001602|UMLS:C0035092|EMAPA:28376|galen:RenalVein|MA:0002210|EHDAA:8722|NCIT:C33462|OpenCyc:Mx4rvdUXKJwpEbGdrcN5Y29ycA|FMA:14334|GAID:544|BTO:0002681|MESH:D012082	hp.json	vein of kidney|kidney vein|venae renales|renal venous tree	http://purl.obolibrary.org/obo/UBERON_0001140		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0013118	biolink:AnatomicalEntity	sulcus of brain	A depression or fissure in the surface of the brain. It surrounds the gyri, creating the characteristic appearance of the brain in humans and other large mammals.	NCIT:C32292|DHBA:10610|HBA:9352	hp.json	sulci & spaces|cerebral sulci|cerebral sulci|cerebral sulcus|sulcus|fissure of brain	http://purl.obolibrary.org/obo/UBERON_0013118		cumbo
GO:0060623	biolink:BiologicalProcess	regulation of chromosome condensation	Any process that modulates the rate, frequency, or extent of chromosome condensation, the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.		hp.json		http://purl.obolibrary.org/obo/GO_0060623		
GO:0045009	biolink:CellularComponent	chitosome	An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum.		hp.json		http://purl.obolibrary.org/obo/GO_0045009		
UBERON:0001146	biolink:AnatomicalEntity	suprarenal vein	A vein that drains the adrenal gland.	MA:0002229|MA:0002081|NCIT:C53129|EHDAA2:0001966|UMLS:C0226717|EHDAA:8731|FMA:14348	hp.json	adrenal vein	http://purl.obolibrary.org/obo/UBERON_0001146		uberon_slim
GO:0060627	biolink:BiologicalProcess	regulation of vesicle-mediated transport	Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060627		
UBERON:0001148	biolink:AnatomicalEntity	median nerve	A nerve of the arm that originates from the brachial plexus and is formed from parts of the medial and lateral cords of the brachial plexus, and continues down the arm to enter the forearm with the brachial artery. It originates from the brachial plexus with roots from C5, C6, C7, C8 &amp; T1.	GAID:843|MESH:D008475|UMLS:C0025058|EHDAA:5648|FMA:14385|MA:0001168|EMAPA:17277|NCIT:C52815|OpenCyc:Mx4rwF4HF5wpEbGdrcN5Y29ycA|EHDAA2:0001086	hp.json	nervus medianus	http://purl.obolibrary.org/obo/UBERON_0001148		uberon_slim|human_reference_atlas
UBERON:0001143	biolink:AnatomicalEntity	hepatic vein	Vein that carries blood away from the liver[ZFA].	XAO:0000387|AAO:0010216|UMLS:C0019155|MA:0003015|ZFA:0000670|MESH:D006503|EMAPA:19221|TAO:0000670|OpenCyc:Mx4rv5GivJwpEbGdrcN5Y29ycA|galen:HepaticVein|FMA:14337|NCIT:C32736|GAID:534	hp.json	hepatic veins|liver vein|vein of liver|venae hepaticae|vena hepatica	http://purl.obolibrary.org/obo/UBERON_0001143		vertebrate_core|pheno_slim|human_reference_atlas|uberon_slim
UBERON:0001142	biolink:AnatomicalEntity	left renal vein	A renal vein that drains the left kidney.	UMLS:C0508001|MA:0002211|NCIT:C52693|EMAPA:37166|OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvdUXKJwpEbGdrcN5Y29ycA|FMA:14336	hp.json		http://purl.obolibrary.org/obo/UBERON_0001142		pheno_slim|human_reference_atlas
UBERON:0001145	biolink:AnatomicalEntity	ovarian vein	A vein that carries deoxygenated blood from its corresponding ovary to inferior vena cava or one of its tributaries.	SCTID:278193003|UMLS:C0226720|EMAPA:18644|NCIT:C53058|Wikipedia:Ovarian_vein|MA:0002186|OpenCyc:Mx4rvrST5ZwpEbGdrcN5Y29ycA|FMA:14346	hp.json	vena ovarica sinistra|vein of gonada of female reproductive system|female reproductive system gonad vein|vein of female reproductive system gonada|female reproductive system gonada vein|vena ovarica dextra|vena ovarica sinistra|vein of female reproductive system gonad|gonada of female reproductive system vein|vein of gonad of female reproductive system|vein of ovary|vena ovarica dextra|gonad of female reproductive system vein|ovary vein	http://purl.obolibrary.org/obo/UBERON_0001145		uberon_slim
UBERON:0001144	biolink:AnatomicalEntity	testicular vein	A vein that carries deoxygenated blood from a single male gonad. It is the male equivalent of the ovarian vein, and is the venous counterpart of the testicular artery. It is a paired vein, with one supplying each testis.	FMA:14344|MA:0002234|UMLS:C0226718|BTO:0002678|OpenCyc:Mx4rv1WIHpwpEbGdrcN5Y29ycA|NCIT:C53050|EMAPA:18647|MA:0002218	hp.json	testicle vein|spermatic vein|testicular venous tree|male gonadal vein|venae spermaticae|vena testicularis sinistra|vena tesicularis|vena testicularis dextra|vein of testicle	http://purl.obolibrary.org/obo/UBERON_0001144		uberon_slim
CHEBI:24500	biolink:ChemicalSubstance	heparan			hp.json	heparans	http://purl.obolibrary.org/obo/CHEBI_24500		3_STAR
UBERON:0001130	biolink:AnatomicalEntity	vertebral column	Subdivision of skeletal system that consists of all the vertebra and associated skeletal elements and joints in the body[modified from VSAO].	EHDA:10119|TAO:0001559|EMAPA:35919|VSAO:0000185|NCIT:C12998|OpenCyc:Mx4rv2j-CpwpEbGdrcN5Y29ycA|VHOG:0001142|AAO:0000734|NCIT:C33588|AAO:0000699|NIF_Subcellular:sao1145756102|EFO:0001369|OpenCyc:Mx4rvVkFEpwpEbGdrcN5Y29ycA|UMLS:C0037949|UMLS:C1519455|XAO:0003074|MESH:D013131|FMA:13478|ZFA:0001559|GAID:106|BTO:0000818|galen:SpinalColumn|OpenCyc:Mx4rv6GF55wpEbGdrcN5Y29ycA|MA:0002416	hp.json	vertebral column skeleton|vertebral region|columna vertebralis|backbone|spine|spinal column|dorsal spine	http://purl.obolibrary.org/obo/UBERON_0001130		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0001136	biolink:AnatomicalEntity	mesothelium	Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).	AEO:0000111|UMLS:C0086610|EHDAA:2349|EHDAA:6073|EHDAA2_RETIRED:0003111|Wikipedia:Mesothelium|EHDAA:646|MA:0000565|NCIT:C33105|EMAPA:32856|FMA:14074|CALOHA:TS-1183|EHDAA:640|EHDAA:2331|BTO:0002422|EHDAA:295|SCTID:361918002	hp.json		http://purl.obolibrary.org/obo/UBERON_0001136		uberon_slim
UBERON:0001135	biolink:AnatomicalEntity	smooth muscle tissue	Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO].	galen:SmoothMuscleTissue|VHOG:0001246|TAO:0005274|EHDAA2:0003141|OpenCyc:Mx4rvvSS3pwpEbGdrcN5Y29ycA|AEO:0000141|NCIT:C12437|EMAPA:32717|galen:SmoothMuscle|BTO:0001260|WBbt:0005781|GAID:167|EFO:0000889|MESH:D009130|MAT:0000303|XAO:0000175|MA:0000166|EV:0100378|UMLS:C1267092|AAO:0010244|MIAA:0000303|FMA:14070|CALOHA:TS-0943|Wikipedia:Smooth_muscle_tissue|ZFA:0005274	hp.json	visceral muscle tissue|smooth muscle|textus muscularis levis; textus muscularis nonstriatus|visceral muscle|textus muscularis nonstriatus|non-striated muscle|textus muscularis levis; textus muscularis nonstriatus|involuntary muscle	http://purl.obolibrary.org/obo/UBERON_0001135		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0001138	biolink:AnatomicalEntity	superior mesenteric vein	In anatomy, the superior mesenteric vein (SMV) is a blood vessel that drains blood from the small intestine. At its termination behind the neck of the pancreas, the SMV combines with the splenic vein to form the hepatic portal vein. The SMV lies to the right of the similarly named artery, the superior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].	BTO:0002783|VHOG:0000552|FMA:14332|EMAPA:18643|NCIT:C33687|OpenCyc:Mx4rwFjmM5wpEbGdrcN5Y29ycA|EHDAA:5414|EHDAA2:0001951|MA:0002179|UMLS:C0226742	hp.json	vena mesenterica superior|upper mesenteric vein	http://purl.obolibrary.org/obo/UBERON_0001138		uberon_slim|human_reference_atlas
UBERON:0001137	biolink:AnatomicalEntity	dorsum	A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column..	GAID:30|NCIT:C13062|UMLS:C0004600|CALOHA:TS-2223|MESH:D001415|Wikipedia:Dorsum_(anatomy)|OpenCyc:Mx4rvVkEU5wpEbGdrcN5Y29ycA|SCTID:123961009|EFO:0001405|BTO:0001713|FMA:14181|MESH:A01.176|galen:Back	hp.json	back|back of body proper|dorsal part of organism	http://purl.obolibrary.org/obo/UBERON_0001137		uberon_slim|efo_slim
UBERON:0001132	biolink:AnatomicalEntity	parathyroid gland	The parathyroid gland is an endocrine gland for secretion of parathyroid hormone, usually found as a pair, embedded in the connective tissue capsule on the posterior surface of the thyroid gland. Parathyroid regulates calcium and phosphorous metabolism.	MA:0000128|MAT:0000082|VHOG:0001188|XAO:0000167|FMA:13890|AAO:0010545|GAID:452|NCIT:C12765|MIAA:0000082|UMLS:C0030518|BTO:0000997|EMAPA:32812|EV:0100134|EFO:0000862|CALOHA:TS-0745|MESH:D010280	hp.json	parathyroid secreting cell|parathyroid|epithelial body	http://purl.obolibrary.org/obo/UBERON_0001132		uberon_slim|organ_slim|pheno_slim
UBERON:0001131	biolink:AnatomicalEntity	vertebral foramen	A foramen within a vertebral element through which the spinal cord runs. It is formed by the anterior segment, and the posterior part, the vertebral arch.	EMAPA:37803|MA:0001454|OpenCyc:Mx4rv_EvQZwpEbGdrcN5Y29ycA|FMA:13479|AAO:0000729	hp.json	vertebra neural canal|foramen vertebrale	http://purl.obolibrary.org/obo/UBERON_0001131		uberon_slim
UBERON:0001134	biolink:AnatomicalEntity	skeletal muscle tissue	Muscle tissue that consists primarily of skeletal muscle fibers.	MA:0002439|FMA:14069|NCIT:C13050|SCTID:426215008|EMAPA:32716|UMLS:C0242692|Wikipedia:Skeletal_striated_muscle	hp.json	skeletal muscle system|skeletal muscle|somatic muscle	http://purl.obolibrary.org/obo/UBERON_0001134		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001133	biolink:AnatomicalEntity	cardiac muscle tissue	Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified].	galen:CardiacMuscleTissue|ZFA:0005280|AEO:0000142|FMA:14068|CALOHA:TS-0440|ncithesaurus:Heart_Muscle|TAO:0005280|galen:CardiacMuscle|AAO:0010245|Wikipedia:Cardiac_muscle|EMAPA:32688|BTO:0000199|BILA:0000134|EHDAA2:0003142	hp.json	myocardium muscle tissue|muscle of heart muscle tissue|textus muscularis of heart myocardium|muscle tissue of muscle of heart|heart muscle muscle tissue|textus muscularis of cardiac muscle|myocardium textus muscularis|heart myocardium muscle tissue|muscle of heart textus muscularis|muscle tissue of myocardium|cardiac muscle muscle tissue|heart muscle textus muscularis|cardiac musculature|muscle tissue of heart muscle|heart myocardium textus muscularis|textus muscularis of myocardium|cardiac muscle textus muscularis|cardiac muscle|muscle tissue of heart myocardium|textus muscularis of muscle of heart|muscle tissue of cardiac muscle|textus muscularis of heart muscle	http://purl.obolibrary.org/obo/UBERON_0001133		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001118	biolink:AnatomicalEntity	lobe of thyroid gland	A lobe of tissue that is part of a thyroid gland.	EMAPA:18196|VHOG:0000732|EHDAA2:0002032|UMLS:C0447647|FMA:13367|NCIT:C33784|MA:0000131	hp.json	thyroid lobe|lobuli glandulae thyroideae|lobus glandulae thyroideae|thyroid gland lobe|lobus (glandula thyroidea)	http://purl.obolibrary.org/obo/UBERON_0001118		
UBERON:0001119	biolink:AnatomicalEntity	right lobe of thyroid gland	A lobe of thyroid gland that is in the right side of a thyroid gland.	MA:0000729|VHOG:0000733|NCIT:C33491|FMA:13368|UMLS:C0229581|EHDAA2:0001759|EMAPA:18198	hp.json	lobus dexter (glandula thyroidea)|right thyroid lobe|thyroid gland right lobe	http://purl.obolibrary.org/obo/UBERON_0001119		
UBERON:0015766	biolink:AnatomicalEntity	epithelium of duct of salivary gland	An epithelium that is part of a duct of salivary gland.	FMA:67682	hp.json	salivary duct epithelium|salivary ductal epithelium|epithelium of salivary duct	http://purl.obolibrary.org/obo/UBERON_0015766		
GO:0045026	biolink:BiologicalProcess	plasma membrane fusion	The joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell.		hp.json	cell fusion|cell-cell fusion	http://purl.obolibrary.org/obo/GO_0045026		
UBERON:0001125	biolink:AnatomicalEntity	serratus ventralis	The serratus ventralis is a muscle that originates on the surface of the upper eight or nine ribs at the side of the chest and inserts along the entire anterior length of the medial border of the scapula. [WP,unvetted].	OpenCyc:Mx4rvWn_D5wpEbGdrcN5Y29ycA|EMAPA:18525|EHDAA:9463|FMA:13397|UMLS:C1710059|EHDAA2:0001832|MA:0002378|NCIT:C53014|VHOG:0000679	hp.json	serratus anterior|Boxer's muscle|serratus ventralis muscle|serratus anterior muscle|serratus lateralis|musculus serratus anterior	http://purl.obolibrary.org/obo/UBERON_0001125		uberon_slim|pheno_slim
UBERON:0001120	biolink:AnatomicalEntity	left lobe of thyroid gland	A lobe of thyroid gland that is in the left side of a thyroid gland.	EHDAA2:0000965|NCIT:C32973|VHOG:0000734|EMAPA:18197|MA:0000728|UMLS:C0229582|FMA:13369	hp.json	left thyroid lobe|thyroid gland left lobe|lobus sinister (glandula thyroidea)	http://purl.obolibrary.org/obo/UBERON_0001120		
UBERON:0013172	biolink:AnatomicalEntity	cricotracheal ligament	The cricotracheal ligament connects the cricoid cartilage with the first ring of the trachea[WP]. The caudal border of the cricoid cartilage is joined to the first ring of the trachea by this ligament. It is an extrinsic laryngeal ligament. It resembles the fibrous membrane which connects the cartilaginous rings of the trachea to each other.	FMA:55259|NCIT:C32405|UMLS:C0225543	hp.json		http://purl.obolibrary.org/obo/UBERON_0013172		
HP:0032391	biolink:PhenotypicFeature	Subcortical heterotopia	A form of heterotopia were the mislocalized gray matter is located deep within the white matter.		hp.json		http://purl.obolibrary.org/obo/HP_0032391		
HP:0032390	biolink:PhenotypicFeature	Periventricular ribbonlike heterotopia	Heterotopia that forms a continuous wavy line along the ventricular wall.		hp.json		http://purl.obolibrary.org/obo/HP_0032390		
HP:0032393	biolink:PhenotypicFeature	Diffuse ribbon-like subcortical heterotopia	Subcortical heterotopia consisting of a bilateral and symmetric single continuous, undulating ribbon-like layer of gray matter located in the frontal, parietal and occipital lobes. It has no visible connection to the overlying cortex.		hp.json		http://purl.obolibrary.org/obo/HP_0032393		
HP:0032392	biolink:PhenotypicFeature	Nodular subcortical heterotopia in peritrigonal regions	Solid nodular heterotopia situated in the region of the peritrigonal optic pathway posterior to the deep gray nuclei.		hp.json		http://purl.obolibrary.org/obo/HP_0032392		
UBERON:0013170	biolink:AnatomicalEntity	cricoarytenoid ligament	Laryngeal ligament that connects the cricoid and arytenoid cartilages[WP,modified].	FMA:55261	hp.json	ligamentum cricoaryteneoideum|crico-arytenoid ligament	http://purl.obolibrary.org/obo/UBERON_0013170		
UBERON:0013171	biolink:AnatomicalEntity	cricothyroid ligament	This attaches the caudal border of the thyroid cartilage to the ventral arch of the cricoid cartilage. Its sheetlike ventral portion is sometimes referred to as the cricothyroid membrane. Being elastic, it 'balances' movement at the hinge-like cricothyroid joint and determines the resting position of the larynx when the muscles are relaxed[MURDOCH]. The cricothyroid ligament is the larger part of the laryngeal membrane, continuing inferiorly as a median or anterior part and twin lateral ligaments. The median cricothyroid ligament is a flat band of white tissue joining the cricoid and thyroid cartilages, while the lateral cricothyroid ligament is also known as the cricothyroid membrane (also called conus elasticus).	FMA:55233|NCIT:C32403|UMLS:C0225542	hp.json	ligamentum cricothyreoideum|crico-thyroid ligament	http://purl.obolibrary.org/obo/UBERON_0013171		
HP:0032399	biolink:PhenotypicFeature	Dysgyria with normal cortical thickness	An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation but with a normal thickness of the cortex.		hp.json		http://purl.obolibrary.org/obo/HP_0032399		
HP:0032398	biolink:PhenotypicFeature	Dysgyria	An abnormal gyral pattern characterized by abnormalities of sulcal depth or orientation.		hp.json		http://purl.obolibrary.org/obo/HP_0032398		
HP:0032395	biolink:PhenotypicFeature	Curvilinear subcortical heterotopia	Large subcortical heterotopia of variable morphology wiht streaks and swirls. These always connect to the overlying cortex in at least one, but usually in multiple, locations. Spaces with the signal intensity of CSF are usually seen within the heterotopia.		hp.json	Giant heterotopia	http://purl.obolibrary.org/obo/HP_0032395		
HP:0032394	biolink:PhenotypicFeature	Mesial parasagittal subcortical heterotopia	Subcortical heterotopia extending along the mesial aspect of the lateral ventricles, with direct connection to mesial polymicrogyria-like cortex at the anterior and posterior limits of the heterotopia.		hp.json		http://purl.obolibrary.org/obo/HP_0032394		
HP:0032397	biolink:PhenotypicFeature	Citrullinuria	An increased concentration of citrulline in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032397		
GO:0060670	biolink:BiologicalProcess	branching involved in labyrinthine layer morphogenesis	The process in which the branches of the fetal placental villi are generated and organized. The villous part of the placenta is called the labyrinth layer.		hp.json		http://purl.obolibrary.org/obo/GO_0060670		
GO:0060671	biolink:BiologicalProcess	epithelial cell differentiation involved in embryonic placenta development	The process in which a trophoblast cell acquires specialized features of an epithelial cell of the placental labyrinthine layer.		hp.json		http://purl.obolibrary.org/obo/GO_0060671		
HP:0032396	biolink:PhenotypicFeature	Transmantle columnar heterotopia	Linear heterotopia spanning from the cerebral mantle from the pia to the ependyma.		hp.json		http://purl.obolibrary.org/obo/HP_0032396		
UBERON:0001194	biolink:AnatomicalEntity	splenic artery	An artery that supplies the spleen.	OpenCyc:Mx4rv0cb2ZwpEbGdrcN5Y29ycA|UMLS:C0037996|FMA:14773|GAID:510|EMAPA:19216|galen:SplenicArtery|MA:0001991|NCIT:C33597|MA:0003177|MESH:D013157	hp.json	arteria splenica|lienal artery|arteria lienalis	http://purl.obolibrary.org/obo/UBERON_0001194		human_reference_atlas|uberon_slim
UBERON:0001193	biolink:AnatomicalEntity	hepatic artery	An artery that supplies the liver.	EMAPA:17859|NCIT:C32729|UMLS:C0019145|MESH:D006499|ZFA:0005161|TAO:0005161|MA:0001963|GAID:496|galen:HepaticArtery|BTO:0004307|OpenCyc:Mx4rvzKtFpwpEbGdrcN5Y29ycA|FMA:14769	hp.json	arteria hepatica propria|arteria hepatica	http://purl.obolibrary.org/obo/UBERON_0001193		uberon_slim|vertebrate_core
GO:0060673	biolink:BiologicalProcess	cell-cell signaling involved in placenta development	Any process that mediates the transfer of information from one cell to another.		hp.json	cell-cell signalling involved in placenta development	http://purl.obolibrary.org/obo/GO_0060673		
GO:0060674	biolink:BiologicalProcess	placenta blood vessel development	The process whose specific outcome is the progression of a blood vessel of the placenta over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0060674		
UBERON:0001190	biolink:AnatomicalEntity	ovarian artery	An artery that supplies an ovary.	FMA:14761|SCTID:244280002|Wikipedia:Ovarian_artery|EMAPA:18620|OpenCyc:Mx4rwOa9PZwpEbGdrcN5Y29ycA|UMLS:C0226411|MA:0002012|NCIT:C33242	hp.json	arteria ovarica|arteria ovarica|ovarian arterial tree	http://purl.obolibrary.org/obo/UBERON_0001190		human_reference_atlas|uberon_slim
UBERON:0001191	biolink:AnatomicalEntity	common iliac artery	The common iliac arteries are two large arteries, about 4cm long in adults but more than a centimetre in diameter, that originate from the aortic bifurcation. The arteries run inferolaterally, along the medial border of the psoas muscles to the pelvic brim, where they bifurcate into the external iliac artery and internal iliac artery. The common iliac artery, and all of its branches, exist as paired structures (that is to say, there is one on the left side and one on the right). The distribution of the common iliac artery is basically the pelvis and lower limb on the corresponding side. Both common iliac arteries are accompanied along their course by common iliac veins. [WP,unvetted].	FMA:14764|NCIT:C32357|MA:0001972|EMAPA:17310|EHDAA:2553|EHDAA2:0000311|OpenCyc:Mx4rvkZ7ZpwpEbGdrcN5Y29ycA|UMLS:C1261084	hp.json	arteria iliaca communis|common iliac arterial tree	http://purl.obolibrary.org/obo/UBERON_0001191		human_reference_atlas|uberon_slim
GO:0072659	biolink:BiologicalProcess	protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.		hp.json	protein localisation in plasma membrane|protein-plasma membrane targeting|protein localization in plasma membrane|protein targeting to plasma membrane	http://purl.obolibrary.org/obo/GO_0072659		goslim_generic|goslim_pombe
GO:0072657	biolink:BiologicalProcess	protein localization to membrane	A process in which a protein is transported to, or maintained in, a specific location in a membrane.		hp.json	protein localisation in membrane|protein localization in membrane	http://purl.obolibrary.org/obo/GO_0072657		
UBERON:0001199	biolink:AnatomicalEntity	mucosa of stomach	The mucosal layer that lines the stomach.	MA:0002683|MESH:D005753|CALOHA:TS-0404|galen:GastricMucosa|OpenCyc:Mx8NhB4rvcD6KJwpEbGdrcN5Y29ycB4rvmKNOpwpEbGdrcN5Y29ycB4rvVj5FpwpEbGdrcN5Y29ycB4rvVjlqpwpEbGdrcN5Y29ycA|UMLS:C0017136|Wikipedia:Gastric_mucosa|MESH:A03.492.766.440|NCIT:C32656|FMA:14907|BTO:0001308|GAID:321|EMAPA:35817|SCTID:362131005	hp.json	stomach organ mucosa|tunica mucosa gastris|tunica mucosa gastris|stomach mucous membrane|mucosa of organ of stomach|tunica mucosa gastricae|ventriculus mucosa|ventriculus organ mucosa|tunica mucosa gastris|ventriculus mucosa of organ|mucous membrane of ventriculus|gastric mucous membrane|organ mucosa of ventriculus|tunica mucosa (gaster)|Magenschleimhaut|gastric mucosa|mucosa of ventriculus|organ mucosa of stomach|ventriculus mucous membrane|mucous membrane of stomach|stomach mucosa of organ|mucosa of organ of ventriculus|stomach mucosa	http://purl.obolibrary.org/obo/UBERON_0001199		pheno_slim|uberon_slim
UBERON:0013161	biolink:AnatomicalEntity	left lateral ventricle	A telencephalic ventricle that is in_the_left_side_of a telencephalon.	FMA:78450	hp.json	left telencephalic ventricle	http://purl.obolibrary.org/obo/UBERON_0013161		
UBERON:0013162	biolink:AnatomicalEntity	right lateral ventricle	A telencephalic ventricle that is in_the_right_side_of a telencephalon.	FMA:78449	hp.json	right telencephalic ventricle	http://purl.obolibrary.org/obo/UBERON_0013162		
UBERON:0013164	biolink:AnatomicalEntity	molariform tooth	A molar or premolar.		hp.json	postcanine tooth|molariform|cheek tooth	http://purl.obolibrary.org/obo/UBERON_0013164		
UBERON:0013160	biolink:AnatomicalEntity	epithalamus ventricular layer		EHDAA2:0000450|VHOG:0000884|EMAPA:17535|EHDAA:5437	hp.json	ventricular layer epithalamus|ventricular layer of epithalamus	http://purl.obolibrary.org/obo/UBERON_0013160		
UBERON:0013167	biolink:AnatomicalEntity	cricopharyngeal ligament	Laryngeal ligament that connects the cricoid cartilage to the pharynx[WP,modified].	FMA:55260	hp.json	crico-pharyngeal ligament|ligamentum cricopharyngeum	http://purl.obolibrary.org/obo/UBERON_0013167		
UBERON:0013168	biolink:AnatomicalEntity	thyroepiglottic ligament	Laryngeal ligament that connects the epiglottis to the thyroid cartilage[WP,modified].	UMLS:C0225514|FMA:55230|NCIT:C33777	hp.json	ligamentum thyroepiglotticum|thyroepiglottic ligament	http://purl.obolibrary.org/obo/UBERON_0013168		
UBERON:0001183	biolink:AnatomicalEntity	inferior mesenteric artery	Mesenteric artery that supplies the large intestine from the left colic (or splenic) flexure to the upper part of the rectum, which includes the descending colon, the sigmoid colon, and part of the rectum. Proximally, its territory of distribution overlaps (forms a watershed) with the middle colic artery, and therefore the superior mesenteric artery. The SMA and IMA anastomose via the marginal artery (artery of Drummond). The territory of distribution of the IMA is more or less equivalent to the embryonic hindgut. [WP,unvetted].	NCIT:C32780|EMAPA:18618|BTO:0002302|EHDAA2:0000817|VHOG:0001116|OpenCyc:Mx4rv-t-S5wpEbGdrcN5Y29ycA|GAID:501|FMA:14750|galen:InferiorMesentericArtery|MA:0002004|MESH:D017537|EHDAA:4345|UMLS:C0162860	hp.json	arteria mesenterica inferior|inferior mesenteric arterial tree|arteria mesenterica inferior|IMA	http://purl.obolibrary.org/obo/UBERON_0001183		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0001182	biolink:AnatomicalEntity	superior mesenteric artery	Mesenteric artery that supplies the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.	UMLS:C0162861|BTO:0002303|EMAPA:18619|VHOG:0000754|EHDAA2:0001949|GAID:502|galen:SuperiorMesentericArtery|MA:0002005|OpenCyc:Mx4rwE5KipwpEbGdrcN5Y29ycA|EHDAA:3358|MESH:D017538|NCIT:C33685|FMA:14749|EHDAA:5313	hp.json	arteria mesenterica superior|arteria mesenterica superior|superior mesenteric arterial tree	http://purl.obolibrary.org/obo/UBERON_0001182		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0001185	biolink:AnatomicalEntity	right renal artery	Renal artery that supplies the right kidney.	OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rveOFHpwpEbGdrcN5Y29ycA|OpenCyc:Mx4rtW8I0KgEEdudWQACs5b6Bw|FMA:14752|EMAPA:37380|NCIT:C52740|MA:0002037|UMLS:C0226332	hp.json	right renal arterial tree	http://purl.obolibrary.org/obo/UBERON_0001185		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0001184	biolink:AnatomicalEntity	renal artery	One of two laterally paired arteries that supplies the kidneys. These are large arteries that branch from the dorsal aorta in primitive vertebrates.	EMAPA:28373|AAO:0010223|GAID:507|MESH:D012077|EHDAA:5321|EFO:0002552|EHDAA2:0004100|BTO:0001165|RETIRED_EHDAA2:0001600|EHDAA:8594|OpenCyc:Mx4rveOFHpwpEbGdrcN5Y29ycA|FMA:14751|UMLS:C0035065|galen:RenalArtery|NCIT:C12778|ZFA:0000420|MA:0002035|TAO:0000420	hp.json	renal arteries|renal arterial tree|arteria renalis	http://purl.obolibrary.org/obo/UBERON_0001184		pheno_slim|human_reference_atlas|efo_slim|uberon_slim|vertebrate_core
GO:0060669	biolink:BiologicalProcess	embryonic placenta morphogenesis	The process in which the embryonic placenta is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060669		
UBERON:0001187	biolink:AnatomicalEntity	testicular artery	One of a pair of arteries that is a branch of the abdominal aorta that supplies blood to a male gonad.	FMA:14758|MA:0002063|EMAPA:18621	hp.json	internal spermatic artery|internal spermatic arteries|internal spermatic vessels|spermatic artery|spermatic arteries|testicular arteries|arteria testicularis|testicular arterial tree|internal spermatic|spermatic vessels	http://purl.obolibrary.org/obo/UBERON_0001187		human_reference_atlas|uberon_slim
UBERON:0001186	biolink:AnatomicalEntity	left renal artery	Renal artery that supplies the left kidney.	OpenCyc:Mx4rtW8I0agEEdudWQACs5b6Bw|FMA:14753|EMAPA:37098|OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rveOFHpwpEbGdrcN5Y29ycA|UMLS:C0226333|NCIT:C52741|MA:0002036	hp.json	left renal arterial tree	http://purl.obolibrary.org/obo/UBERON_0001186		pheno_slim|human_reference_atlas
UBERON:0001189	biolink:AnatomicalEntity	left testicular artery	A testicular artery that supplies a left testicle.	NCIT:C52739|UMLS:C0734077|MA:0002041|EMAPA:37099|FMA:14760	hp.json	trunk of left testicular arterial tree|left spermatic artery	http://purl.obolibrary.org/obo/UBERON_0001189		human_reference_atlas
UBERON:0001188	biolink:AnatomicalEntity	right testicular artery	A testicular artery that supplies a right testicle.	FMA:14759|NCIT:C52738|MA:0002042|UMLS:C0734076|EMAPA:37382	hp.json	trunk of right testicular arterial tree|right spermatic artery	http://purl.obolibrary.org/obo/UBERON_0001188		human_reference_atlas
UBERON:0013150	biolink:AnatomicalEntity	future brain vesicle		NCIT:C34259	hp.json	brain vesicle|secondary brain vesicle|primary brain vesicle|primitive brain vesicle|early brain vesicle	http://purl.obolibrary.org/obo/UBERON_0013150		
UBERON:0013151	biolink:AnatomicalEntity	choroidal artery	One of two arteries (anterior and posterior choroidal artery) that supply blood to the choroid plexus, optic tract, hippocampus, globus pallidus, and other various brain regions.	NCIT:C32310|UMLS:C0226164	hp.json	choroid artery|artery of choroid plexus	http://purl.obolibrary.org/obo/UBERON_0013151		
UBERON:0013158	biolink:AnatomicalEntity	foregut-midgut junction gland	A gland that is part of a foregut-midgut junction.	EHDAA2:0000574|EMAPA:17065	hp.json	gland of foregut-midgut junction	http://purl.obolibrary.org/obo/UBERON_0013158		
UBERON:0013159	biolink:AnatomicalEntity	epithalamus mantle layer		VHOG:0000913|EHDAA:5435|EHDAA2:0000449|EMAPA:17533	hp.json	mantle layer of epithalamus|mantle layer epithalamus	http://purl.obolibrary.org/obo/UBERON_0013159		
GO:0045058	biolink:NamedThing	T cell selection			hp.json		http://purl.obolibrary.org/obo/GO_0045058		
UBERON:0013156	biolink:AnatomicalEntity	1st arch mandibular endoderm		EMAPA:16384|EHDAA2:0000033	hp.json	endoderm of mandibular component	http://purl.obolibrary.org/obo/UBERON_0013156		
UBERON:0001172	biolink:AnatomicalEntity	hepatic acinus	The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids.	NCIT:C32992|MA:0002496|FMA:14654|EMAPA:35497|UMLS:C0227519	hp.json	portal acinus|liver acinus	http://purl.obolibrary.org/obo/UBERON_0001172		
UBERON:0001171	biolink:AnatomicalEntity	portal lobule	The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.	NCIT:C33341|FMA:14653|UMLS:C0682620|MA:0002498	hp.json		http://purl.obolibrary.org/obo/UBERON_0001171		pheno_slim
UBERON:0001174	biolink:AnatomicalEntity	common bile duct	The part of the biliary tree formed by the union of the cystic duct and the common hepatic duct.	NCIT:C12698|EHDAA:3981|GAID:282|MESH:D003135|UMLS:C0009437|ZFA:0005165|VHOG:0000214|FMA:14667|TAO:0005165|EHDAA2:0000303|EMAPA:17201|MA:0001631|galen:CommonBileDuct	hp.json	ductus choledochus|ductus choledochus (biliaris)	http://purl.obolibrary.org/obo/UBERON_0001174		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0001173	biolink:AnatomicalEntity	biliary tree	A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder.	EMAPA:35172|AAO:0011020|UMLS:C0005423|FMA:14665|XAO:0000455	hp.json	biliary tract	http://purl.obolibrary.org/obo/UBERON_0001173		organ_slim|pheno_slim|uberon_slim
UBERON:0001170	biolink:AnatomicalEntity	mesentery of small intestine	The peritoneum responsible for connecting the jejunum and ileum (parts of the small intestine) to the back wall of the abdomen. Between the two sheets of peritoneum are blood vessels, lymph vessels, and nerves. This allows these parts of the small intestine to move relatively freely within the abdominopelvic cavity. The brain, however, cannot map sensation accurately, so sensation is usually referred to the midline, an example of referred pain[WP].	FMA:14643|MA:0001555|EMAPA:37745	hp.json	mesentery (proper)|mesentery proper|small intestine mesentery|small intestinal mesentery	http://purl.obolibrary.org/obo/UBERON_0001170		
UBERON:0001179	biolink:AnatomicalEntity	peritoneal cavity	Anatomical cavity bounded by visceral and parietal peritoneum.	SCTID:181616008|EHDAA2:0001446|UMLS:C1704247|Wikipedia:Peritoneal_cavity|MA:0000054|FMA:14704|GAID:24|VHOG:0000852|MESH:D010529|BTO:0001782|EMAPA:16138|NCIT:C12769	hp.json	saccus serosus peritonei|saccus serosus peritonei|cavitas peritonealis|cavitas peritonealis|cavitas peritonealis	http://purl.obolibrary.org/obo/UBERON_0001179		pheno_slim|uberon_slim
GO:0072678	biolink:BiologicalProcess	T cell migration	The movement of a T cell within or between different tissues and organs of the body.		hp.json	T-lymphocyte migration|T-cell migration|T lymphocyte migration	http://purl.obolibrary.org/obo/GO_0072678		
UBERON:0001176	biolink:AnatomicalEntity	right hepatic duct	The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct.	NCIT:C33476|VHOG:0000217|EHDAA:3992|FMA:14669|EMAPA:32797|MA:0001639|EHDAA2:0001727|UMLS:C0227557	hp.json	ductus hepaticus dexter	http://purl.obolibrary.org/obo/UBERON_0001176		
GO:0072676	biolink:BiologicalProcess	lymphocyte migration	The movement of a lymphocyte within or between different tissues and organs of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0072676		
GO:0070013	biolink:CellularComponent	intracellular organelle lumen	An organelle lumen that is part of an intracellular organelle.		hp.json		http://purl.obolibrary.org/obo/GO_0070013		
UBERON:0001175	biolink:AnatomicalEntity	common hepatic duct	Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP].	GAID:286|EMAPA:19101|MA:0002660|UMLS:C0019149|MESH:D006500|FMA:14668|VHOG:0000220|NCIT:C32356	hp.json	ductus hepaticus communis|hepatic duct	http://purl.obolibrary.org/obo/UBERON_0001175		pheno_slim|uberon_slim
UBERON:0001178	biolink:AnatomicalEntity	visceral peritoneum	The inner layer of peritoneum that is wrapped around organs located inside the intraperitoneal space.	VHOG:0001528|EMAPA:16592|Wikipedia:Visceral_peritoneum|FMA:14703|ZFA:0005132|TAO:0005132|SCTID:362702003	hp.json	visceral serous membrane of peritoneum	http://purl.obolibrary.org/obo/UBERON_0001178		uberon_slim|vertebrate_core
GO:0072674	biolink:BiologicalProcess	multinuclear osteoclast differentiation	The process in which a relatively unspecialized monocyte acquires the specialized features of a multinuclear osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.		hp.json	multinuclear osteoclast morphogenesis|multinuclear osteoclast formation	http://purl.obolibrary.org/obo/GO_0072674		
UBERON:0001177	biolink:AnatomicalEntity	left hepatic duct	The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct.	UMLS:C0227560|FMA:14670|NCIT:C32960|VHOG:0000218|EHDAA:3990|EMAPA:32795|MA:0001638|EHDAA2:0000941	hp.json	ductus hepaticus sinister	http://purl.obolibrary.org/obo/UBERON_0001177		
UBERON:0013140	biolink:AnatomicalEntity	systemic vein	Any vein within the general circulation that transports blood back to the right atrium of the heart.	SCTID:244389004|FMA:66644|NCIT:C33719|UMLS:C0447117	hp.json	systemic venous tree organ part	http://purl.obolibrary.org/obo/UBERON_0013140		
UBERON:0013142	biolink:AnatomicalEntity	soleal vein	A vein that drains the soleus.		hp.json	vena solealis|soleus vein|vein of soleus muscle	http://purl.obolibrary.org/obo/UBERON_0013142		human_reference_atlas
UBERON:0013147	biolink:AnatomicalEntity	early mesencephalic vesicle		EHDAA2:0001102	hp.json	mesencephalic vesicle	http://purl.obolibrary.org/obo/UBERON_0013147		
UBERON:0013148	biolink:AnatomicalEntity	early midbrain vesicle		EHDAA2:0001103	hp.json	midbrain vesicle	http://purl.obolibrary.org/obo/UBERON_0013148		
UBERON:0013149	biolink:AnatomicalEntity	hindbrain vesicle		EMAPA:16917|EHDAA2:0000101	hp.json	rhombencephalic vesicle	http://purl.obolibrary.org/obo/UBERON_0013149		
UBERON:0013143	biolink:AnatomicalEntity	gastrocnemius vein	A vein that drains the gastrocnemius.		hp.json	vena gastrocnemii|vein of gastrocnemius muscle	http://purl.obolibrary.org/obo/UBERON_0013143		human_reference_atlas
UBERON:0001161	biolink:AnatomicalEntity	body of stomach	The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO].	NCIT:C12258|galen:GastricCorpus|UMLS:C0227230|EMAPA:35810|MA:0002559|BTO:0000505|FMA:14560	hp.json	stomach body|corpus gastricum (ventriculare)|corpus gastricum|gastric corpus|corpus ventriculi|gastric body|corpus gastricum|corpus ventriculare	http://purl.obolibrary.org/obo/UBERON_0001161		uberon_slim
GO:0060688	biolink:BiologicalProcess	regulation of morphogenesis of a branching structure	Any process that modulates the rate, frequency, or extent of branching morphogenesis, the process in which the anatomical structures of branches are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060688		
UBERON:0001169	biolink:AnatomicalEntity	wall of large intestine	An anatomical wall that is part of a large intestine [Automatically generated definition].	EMAPA:35470|FMA:14619|MA:0002695	hp.json	large intestinal wall|large intestine anatomical wall|large intestine wall|anatomical wall of large intestine	http://purl.obolibrary.org/obo/UBERON_0001169		
UBERON:0001168	biolink:AnatomicalEntity	wall of small intestine	An anatomical wall that is part of a small intestine [Automatically generated definition].	MA:0002696|NCIT:C33573|FMA:14615|EMAPA:35785|UMLS:C1519375	hp.json	small bowel anatomical wall|small intestine wall|small intestinal wall|anatomical wall of small bowel|small intestine anatomical wall|wall of small bowel|small bowel wall|anatomical wall of small intestine	http://purl.obolibrary.org/obo/UBERON_0001168		
GO:0072666	biolink:BiologicalProcess	establishment of protein localization to vacuole	The directed movement of a protein to a specific location in a vacuole.		hp.json	establishment of protein localisation to vacuole	http://purl.obolibrary.org/obo/GO_0072666		
UBERON:0001165	biolink:AnatomicalEntity	pyloric antrum	The area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells.	GAID:332|NCIT:C12259|EMAPA:17891|BTO:0001732|UMLS:C0034193|EFO:0002555|FMA:14579|MESH:D011706|galen:PyloricAntrum|MA:0001624	hp.json	antrum of Willis|stomach pyloric antrum|antrum of stomach|antrum|stomach antrum|gastric antrum|antrum pylori|antrum pyloricum|antrum pyloricum	http://purl.obolibrary.org/obo/UBERON_0001165		pheno_slim|efo_slim|uberon_slim
GO:0072665	biolink:BiologicalProcess	protein localization to vacuole	A process in which a protein is transported to, or maintained at, a location in a vacuole.		hp.json	protein localisation to vacuole	http://purl.obolibrary.org/obo/GO_0072665		
UBERON:0001167	biolink:AnatomicalEntity	wall of stomach	The layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between.	FMA:14582|EMAPA:35826|galen:WallOfStomach|MA:0002692|SCTID:279995000	hp.json	stomach anatomical wall|ventriculus wall|anatomical wall of ventriculus|wall of ventriculus|gastric wall|anatomical wall of stomach|ventriculus anatomical wall|stomach wall	http://purl.obolibrary.org/obo/UBERON_0001167		pheno_slim
UBERON:0001166	biolink:AnatomicalEntity	pylorus	The stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum.	FMA:14581|MA:0002560|EHDAA:4860|MESH:D011708|galen:Pylorus|UMLS:C0034196|BTO:0001146|EHDAA2:0001580|NCIT:C12260|VHOG:0000420|EMAPA:17631|GAID:333	hp.json	stomach pyloric region|pyloric part of stomach|valvula pylori|pyloric region|pars pylorica|pars pylorica gastricae	http://purl.obolibrary.org/obo/UBERON_0001166		pheno_slim|uberon_slim
UBERON:0003849	biolink:AnatomicalEntity	mesencephalic neural crest	A neural crest that has_potential_to_developmentally_contribute_to a midbrain.	EFO:0003591|EHDAA2:0001101|ZFA:0000935|VHOG:0000796|EHDAA:360|TAO:0000935	hp.json	mesencephalic neural crest|neural crest midbrain	http://purl.obolibrary.org/obo/UBERON_0003849		vertebrate_core|efo_slim
HP:0032591	biolink:PhenotypicFeature	Renal interstitial hemosiderin	Deposition of hemosiderin (a golden-brown, granular pigment derived from ferritin) in interstitial cells of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032591		
HP:0032590	biolink:PhenotypicFeature	Renal neutrophilic tubulitis	Infiltration of the renal tubular epithelium by neutrophils.		hp.json		http://purl.obolibrary.org/obo/HP_0032590		
UBERON:0003847	biolink:AnatomicalEntity	thyroid artery	An artery that supplies a thyroid gland.	EHDAA:7372|EMAPA:18622|EHDAA2:0002029|UMLS:C1711424|MA:0002066|NCIT:C53020|VHOG:0001366|AAO:0010490	hp.json		http://purl.obolibrary.org/obo/UBERON_0003847		
UBERON:0003848	biolink:AnatomicalEntity	gonadal vein	In medicine, gonadal vein refers to the blood vessel that carrying blood away from the gonad (testis, ovary) toward the heart. Females : ovarian vein Males : testicular vein [WP,unvetted].	VHOG:0001340|EHDAA:8703|OpenCyc:Mx4rvlWYh5wpEbGdrcN5Y29ycA|EHDAA2:0000719|SCTID:278192008|Wikipedia:Gonadal_vein	hp.json	gonada vein|vein of gonad|gonad vein|vein of gonada	http://purl.obolibrary.org/obo/UBERON_0003848		
UBERON:0003845	biolink:AnatomicalEntity	lower eyelid epithelium	An epithelium that is part of a lower eyelid [Automatically generated definition].	EHDAA2:0001016|VHOG:0000637|EMAPA:17832	hp.json	inferior eyelid epithelium|lower eyelid epithelial tissue|epithelial tissue of lower eyelid|epithelium of inferior eyelid|epithelium of lower eyelid|epithelial tissue of inferior eyelid|inferior eyelid epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003845		
GO:0008206	biolink:NamedThing	bile acid metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0008206		
UBERON:0003846	biolink:AnatomicalEntity	thymus epithelium	An epithelium that is part of a thymus, forming a supporting framework[MP,modified].	ZFA:0005779|NCIT:C45713|EHDAA2:0002019|BTO:0001836|CALOHA:TS-1040|UMLS:C1711423|VHOG:0001426|EMAPA:35864|MA:0000768	hp.json	thymus epithelial tissue|thymus gland epithelium|epithelial tissue of thymus gland|thymic epithelial tissue|thymic epithelium|epithelium of thymus gland|epithelial tissue of thymus|epithelium of thymus|thymus gland epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003846		pheno_slim|human_reference_atlas
HP:0032597	biolink:PhenotypicFeature	Renal tubular epithelial cell sloughing	At least one free floating cell in the tubular lumen without attachment to adjacent cells or basement membrane in a tubular cross section without detachment. These cells must not aggregate into a tubular shape and completely fill the lumen, if so, it should be classified as a cast.		hp.json		http://purl.obolibrary.org/obo/HP_0032597		
GO:0008203	biolink:BiologicalProcess	cholesterol metabolic process	The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.		hp.json	cholesterol metabolism	http://purl.obolibrary.org/obo/GO_0008203		
HP:0032596	biolink:PhenotypicFeature	Renal tubular epithelial cell cytoplasmic vacuolization	Tubular cross section with intracytoplasmic vacuoles in at least one tubular epithelial cell. This feature is classified as isometric when vacuoles are round and similar in size and coarse when vacuoles were not round in shape or varied in size.		hp.json		http://purl.obolibrary.org/obo/HP_0032596		
HP:0032599	biolink:PhenotypicFeature	Abnormal renal tubular epithelial morphology	Any structural anomaly of the renal tubular epithelial cells (RTEC), a layer of cells in the outer layer of the renal tubule. These cells play a role in the absorption of substances such as glucose and amino from the primary urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032599		
UBERON:0015834	biolink:AnatomicalEntity	duodenum lamina propria	A lamina propria that is part of a duodenum.	EMAPA:27255|MA:0003209|FMA:15972	hp.json	lamina propria mucosae of duodenum|lamina propria of duodenum|duodenal lamina propria	http://purl.obolibrary.org/obo/UBERON_0015834		human_reference_atlas
GO:0008202	biolink:BiologicalProcess	steroid metabolic process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.	Wikipedia:Steroid_metabolism	hp.json	steroid metabolism	http://purl.obolibrary.org/obo/GO_0008202		
UBERON:0015833	biolink:AnatomicalEntity	foregut epithelium	An epithelium that is part of a foregut.	MA:0003204|EMAPA:32922	hp.json		http://purl.obolibrary.org/obo/UBERON_0015833		
HP:0032598	biolink:PhenotypicFeature	Blebbing of apical cytoplasm of renal tubular epithelial cells	Tubular cross section with round/irregular cytoplasmic protrusion, shaped like the Greek capital letter Omega (or it may be more vertically elongated Omega), pinched off from apical membrane without apparent closure of the lumen, involving over 50 percent of the tubular cells in cross section. The feature can be further classified into proximal or distal tubule.		hp.json		http://purl.obolibrary.org/obo/HP_0032598		
HP:0032593	biolink:PhenotypicFeature	Myoglobin casts	A type of acelluar casts with positive myoglobin staining A that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented.		hp.json		http://purl.obolibrary.org/obo/HP_0032593		
HP:0032592	biolink:PhenotypicFeature	Aplasia of the right hemidiaphragm	Congenital absence of the right-sided diaphragm.		hp.json	Right diaphragmatic hernia	http://purl.obolibrary.org/obo/HP_0032592		
HP:0032595	biolink:PhenotypicFeature	Renal tubular epithelial cell detachment	Tubular cross section with a space between the basolateral aspect of tubular epithelium and its basement membrane; classified as global when at least 2/3 circumference of the tubular cross section are involved and segmental when less than 2/3 are involved.		hp.json		http://purl.obolibrary.org/obo/HP_0032595		
HP:0032594	biolink:PhenotypicFeature	Renal tubular basement membrane denudation	Naked basement membranes without tubular epithelium.		hp.json	Denuded tubular basement membrane	http://purl.obolibrary.org/obo/HP_0032594		
UBERON:0003854	biolink:AnatomicalEntity	spinal cord neural plate	A neural plate that develops_from a future spinal cord.	VHOG:0000439|FMA:312957|ZFA:0007021|TAO:0007021	hp.json	neural plate of spinal cord	http://purl.obolibrary.org/obo/UBERON_0003854		
UBERON:0003855	biolink:AnatomicalEntity	gonad mesenchyme	Mesenchyme that is part of a developing gonad [Automatically generated definition].	EMAPA:17385|EMAPA:16858|VHOG:0001090|EHDAA:5012	hp.json	mesenchyme of gonada|mesenchyme of gonad|gonada mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003855		pheno_slim
UBERON:0003852	biolink:AnatomicalEntity	rhombencephalon neural crest	A neural crest that has_potential_to_developmentally_contribute_to a hindbrain.	EMAPA:35747|EHDAA:362|EHDAA2:0001628|ZFA:0007063|VHOG:0001210|TAO:0007063	hp.json	neural crest hindbrain|rhombencephalic neural crest|rhombomere neural crest	http://purl.obolibrary.org/obo/UBERON_0003852		vertebrate_core
UBERON:0003853	biolink:AnatomicalEntity	spinal cord neural crest	A neural crest that has_potential_to_developmentally_contribute_to a spinal cord.	EMAPA:16881|EHDAA:696|EMAPA:16163|VHOG:0001006	hp.json	neural crest spinal cord|spinal neural crest	http://purl.obolibrary.org/obo/UBERON_0003853		
UBERON:0003850	biolink:AnatomicalEntity	telencephalon neural crest	A neural crest that has_potential_to_developmentally_contribute_to a telencephalon.	VHOG:0000799|ZFA:0000812|EFO:0003574|TAO:0000812|RETIRED_EHDAA2:0001991	hp.json	neural crest telencephalon	http://purl.obolibrary.org/obo/UBERON_0003850		efo_slim|vertebrate_core
UBERON:0003851	biolink:AnatomicalEntity	diencephalon neural crest	A neural crest that has_potential_to_developmentally_contribute_to a diencephalon.	EMAPA:16518|VHOG:0000798|ZFA:0000811|EFO:0003573|EHDAA2:0000603|TAO:0000811	hp.json	neural crest diencephalon|neural crest of future diencephalon|future diencephalon neural crest|diencephalic neural crest	http://purl.obolibrary.org/obo/UBERON_0003851		efo_slim
UBERON:0003838	biolink:AnatomicalEntity	abdominal segment connective tissue	A portion of connective tissue that is part of an abdominal segment of trunk [Automatically generated definition].	EMAPA:37059|MA:0000526	hp.json	textus connectivus of abdominal segment of trunk|abdominal segment of trunk portion of connective tissue|abdominal segment of trunk connective tissue|abdominal segment of trunk textus connectivus|connective tissue of abdominal segment of trunk|portion of connective tissue of abdominal segment of trunk	http://purl.obolibrary.org/obo/UBERON_0003838		
UBERON:0003839	biolink:AnatomicalEntity	forelimb joint	A limb joint that is part of a forelimb [Automatically generated definition].	MA:0000614|EMAPA:19204	hp.json	forelimb joint of limb|limb joint of forelimb|superior member limb joint|limb joint of anteriormost limb|limb joint of upper extremity|limb joint of fore limb|forelimb limb joint|superior member joint of limb|joint of limb of forelimb|upper extremity joint of limb|anteriormost limb joint of limb|wing joint|fore limb joint of limb|joint of limb of superior member|joint of limb of anteriormost limb|joint of limb of upper extremity|joint of limb of fore limb|fore limb limb joint|joint of free upper limb|anteriormost limb limb joint|upper extremity limb joint|limb joint of superior member	http://purl.obolibrary.org/obo/UBERON_0003839		pheno_slim
GO:0008219	biolink:BiologicalProcess	cell death	Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).		hp.json	necrosis|accidental cell death	http://purl.obolibrary.org/obo/GO_0008219		goslim_chembl|goslim_mouse|goslim_agr|goslim_plant|goslim_drosophila
UBERON:0003836	biolink:AnatomicalEntity	abdominal segment skin	A skin of body that is part of an abdominal segment of trunk [Automatically generated definition].	EMAPA:37063|MA:0000530|FMA:264898	hp.json	skin of abdominal segment of trunk|abdominal segment of trunk skin	http://purl.obolibrary.org/obo/UBERON_0003836		
UBERON:0003837	biolink:AnatomicalEntity	thoracic segment connective tissue	A portion of connective tissue that is part of a thorax [Automatically generated definition].	MA:0000560|EMAPA:37253	hp.json	thorax textus connectivus|portion of connective tissue of thorax|connective tissue of thorax|upper body connective tissue|thorax portion of connective tissue|textus connectivus of thorax|thorax connective tissue	http://purl.obolibrary.org/obo/UBERON_0003837		
UBERON:0003834	biolink:AnatomicalEntity	thoracic segment blood vessel	A blood vessel that is part of a thorax [Automatically generated definition].	EMAPA:37238|MA:0000558	hp.json	thorax blood vessel|upper body blood vessel|blood vessel of thorax	http://purl.obolibrary.org/obo/UBERON_0003834		
GO:0008217	biolink:NamedThing	regulation of blood pressure			hp.json		http://purl.obolibrary.org/obo/GO_0008217		
UBERON:0003835	biolink:AnatomicalEntity	abdominal segment blood vessel	A blood vessel that is part of an abdominal segment of trunk [Automatically generated definition].	MA:0000524|EMAPA:37057	hp.json	blood vessel of abdominal segment of trunk|abdominal segment of trunk blood vessel	http://purl.obolibrary.org/obo/UBERON_0003835		
GO:0008212	biolink:NamedThing	mineralocorticoid metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0008212		
GO:0008211	biolink:NamedThing	glucocorticoid metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0008211		
UBERON:0015814	biolink:AnatomicalEntity	outer ear epithelium	An epithelium that is part of a external ear.	MA:0003170|EMAPA:35956	hp.json		http://purl.obolibrary.org/obo/UBERON_0015814		
UBERON:0015813	biolink:AnatomicalEntity	middle ear epithelium	An epithelium that is part of a middle ear.	EMAPA:35673|MA:0003169	hp.json		http://purl.obolibrary.org/obo/UBERON_0015813		
UBERON:0003843	biolink:AnatomicalEntity	dental epithelium	Epithelium that is part of a developing tooth or dental organ.	XAO:0003203|EMAPA:32903|AAO:0011027|BTO:0001723|UMLS:C1709309|ZFA:0005134|NCIT:C54296|TAO:0005134|MA:0003151|VHOG:0001443	hp.json	dental epithelium|tooth epithelium|odontogenic epithelium|reduced enamel epithelium|dental epithelia	http://purl.obolibrary.org/obo/UBERON_0003843		vertebrate_core
UBERON:0003844	biolink:AnatomicalEntity	upper eyelid epithelium	An epithelium that is part of an upper eyelid [Automatically generated definition].	EHDAA2:0002116|VHOG:0000638|EMAPA:17835	hp.json	superior eyelid epithelial tissue|upper eyelid epithelial tissue|epithelial tissue of upper eyelid|epithelium of upper eyelid|epithelium of superior eyelid|superior eyelid epithelium|epithelial tissue of superior eyelid	http://purl.obolibrary.org/obo/UBERON_0003844		
UBERON:0003841	biolink:AnatomicalEntity	autopod joint	A limb joint that is part of an autopod [Automatically generated definition].	EMAPA:35160|MA:0002715	hp.json	autopod joint of limb|paw joint|joint of limb of autopod|joint of limb of distal free limb segment|autopod limb joint|distal free limb segment limb joint|limb joint of autopod|limb joint of distal free limb segment|distal free limb segment joint of limb	http://purl.obolibrary.org/obo/UBERON_0003841		
UBERON:0003842	biolink:AnatomicalEntity	neural tube lumen	An anatomical space that surrounded_by a neural tube.	EMAPA:16167|EHDAA2:0001269|XAO:0000252|VHOG:0001119|EHDAA:914|AAO:0011073|EHDAA:2889	hp.json	neural tube neural lumen|cavity of neural tube|central lumen|cavity of neural tube|neural lumen|prosencoel|lumen of neural tube|neurocoel|lumen of neural tube	http://purl.obolibrary.org/obo/UBERON_0003842		
UBERON:0003840	biolink:AnatomicalEntity	hindlimb joint	A limb joint that is part of a hindlimb [Automatically generated definition].	MA:0000662|EMAPA:32635	hp.json	joint of limb of hind limb|lower extremity joint of limb|joint of lower limb|joint of limb of lower extremity|limb joint of inferior member|joint of limb of hindlimb|limb joint of hind limb|lower extremity limb joint|joint of free lower limb|hindlimb limb joint|hind limb limb joint|inferior member joint of limb|limb joint of lower extremity|hind limb joint of limb|inferior member limb joint|hindlimb joint of limb|joint of limb of inferior member|limb joint of hindlimb	http://purl.obolibrary.org/obo/UBERON_0003840		pheno_slim
UBERON:0003829	biolink:AnatomicalEntity	urethra muscle tissue	Any muscle tissue that is part of the urethra.	MA:0002649|EMAPA:37787	hp.json	urethral muscle layer	http://purl.obolibrary.org/obo/UBERON_0003829		
GO:0035809	biolink:NamedThing	regulation of urine volume			hp.json		http://purl.obolibrary.org/obo/GO_0035809		
UBERON:0003827	biolink:AnatomicalEntity	thoracic segment bone	A bone that is part of a thorax [Automatically generated definition].	MA:0000559|SCTID:426649006|EMAPA:37247	hp.json	upper body bone|bone organ of thorax|bone of thorax|thorax bone organ|thorax bone	http://purl.obolibrary.org/obo/UBERON_0003827		
UBERON:0003828	biolink:AnatomicalEntity	abdominal segment bone	A bone that is part of an abdominal segment of trunk [Automatically generated definition].	MA:0000525|EMAPA:37058	hp.json	bone organ of abdominal segment of trunk|bone of abdominal segment of trunk|abdominal segment of trunk bone organ|abdominal segment of trunk bone	http://purl.obolibrary.org/obo/UBERON_0003828		
UBERON:0003825	biolink:AnatomicalEntity	nerve of abdominal segment	A nerve that is part of an abdominal segment of trunk [Automatically generated definition].	EMAPA:37061|MA:0000528	hp.json	abdominal segment nerve	http://purl.obolibrary.org/obo/UBERON_0003825		
UBERON:0003826	biolink:AnatomicalEntity	upper leg bone	A bone that is part of a hindlimb stylopod [Automatically generated definition].	EMAPA:35893|MA:0000682	hp.json	femur	http://purl.obolibrary.org/obo/UBERON_0003826		
UBERON:0003823	biolink:AnatomicalEntity	hindlimb zeugopod	The middle limb segment of the pelvic free limb, between the autopod and stylopod segments. Includes as parts the hindlimb zeugopodial skeleton, which includes as parts the tibia and fibula, or their cartilage precursors, or evolutionary variants.	galen:Leg|NCIT:C32974|EFO:0003051|OpenCyc:Mx4rvczZBpwpEbGdrcN5Y29ycA|EHDAA:6190|EMAPA:17496|FMA:24979|MESH:D007866|UMLS:C1140621|VHOG:0000348|MA:0000051|VSAO:0005060|EHDAA:5165|EHDAA2:0001030|FMA:24984	hp.json	hindlimb epipodium|middle limb segment of hind limb|regio surae|zeugopod of hind limb|posterior part of leg|crus of hindlimb|regio cruris posterior|posterior region of leg|lower extremity zeugopod|calf|lower leg|calf of leg|hind limb middle limb segment|middle limb segment of hindlimb|hindlimb zeugopod|hindlimb middle limb segment|crus|hind limb zeugopod|intermediate segment of free lower limb|leg|hindlimb zeugopodium|sural region|hind limb zeudopodium|lower extremity middle limb segment|posterior leg region|zeugopod of hindlimb|sura|posterior curral region|hind epipodium|hindlimb zeudopodium|shank	http://purl.obolibrary.org/obo/UBERON_0003823		pheno_slim|efo_slim
UBERON:0003824	biolink:AnatomicalEntity	nerve of thoracic segment	A nerve that is part of a thorax [Automatically generated definition].	MESH:D013900|MA:0000562|SCTID:359876006|EMAPA:37265	hp.json	nerve of thorax|upper body nerve|thorax nerve|thoracic segment nerve	http://purl.obolibrary.org/obo/UBERON_0003824		
GO:0035805	biolink:CellularComponent	egg coat	A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.		hp.json	zona pellucida|vitelline membrane	http://purl.obolibrary.org/obo/GO_0035805		
UBERON:0015807	biolink:AnatomicalEntity	ear epithelium	An epithelium that is part of a ear.	MA:0003161|EMAPA:32800	hp.json		http://purl.obolibrary.org/obo/UBERON_0015807		
CHEBI:85425	biolink:ChemicalSubstance	glycine transporter inhibitor	Any substance that inhibits the action of glycine transporters.		hp.json	glycine transporter inhibitors	http://purl.obolibrary.org/obo/CHEBI_85425		3_STAR
UBERON:0015808	biolink:AnatomicalEntity	eye epithelium	An epithelium that is part of a camera-type eye.	MA:0003162|EMAPA:35957	hp.json		http://purl.obolibrary.org/obo/UBERON_0015808		
UBERON:0003832	biolink:AnatomicalEntity	esophagus muscle	Any muscle organ that is part of a esophagus [Automatically generated definition].	EMAPA:26983|MA:0002682|SCTID:360961009	hp.json	esophageal muscle|muscle organ of oesophagus|muscle organ of gullet|esophagus muscle organ|gullet muscle organ|oesophagus muscle organ|muscle organ of esophagus	http://purl.obolibrary.org/obo/UBERON_0003832		
UBERON:0003833	biolink:AnatomicalEntity	abdominal segment muscle	A muscle organ that is part of an abdominal segment of trunk [Automatically generated definition].	EMAPA:37060|MA:0000527	hp.json	abdominal segment of trunk muscle organ|muscle organ of abdominal segment of trunk	http://purl.obolibrary.org/obo/UBERON_0003833		
UBERON:0003830	biolink:AnatomicalEntity	thoracic segment muscle	Any muscle organ that is part of a thorax [Automatically generated definition].	MA:0000561	hp.json	muscle organ of thorax|thorax muscle organ|upper body muscle	http://purl.obolibrary.org/obo/UBERON_0003830		
UBERON:0003831	biolink:AnatomicalEntity	respiratory system muscle	Any muscle organ that is part of a respiratory system [Automatically generated definition].	MA:0001828|EMAPA:35733	hp.json	muscle organ of respiratory system|muscle organ of apparatus respiratorius|respiratory system muscle organ|apparatus respiratorius muscle organ	http://purl.obolibrary.org/obo/UBERON_0003831		
CHEBI:24470	biolink:ChemicalSubstance	haloamino acid	Any non-proteinogenic amino acid carrying at least one halo group.		hp.json	haloamino acids	http://purl.obolibrary.org/obo/CHEBI_24470		3_STAR
CHEBI:24473	biolink:ChemicalSubstance	halogen			hp.json	group VII elements|halogenes|Halogene|halogene|halogens|group 17 elements|halogeno|halogenos|halogen	http://purl.obolibrary.org/obo/CHEBI_24473		3_STAR
CHEBI:24471	biolink:ChemicalSubstance	halogen molecular entity			hp.json	halogen molecular entity|halogen molecular entities|halogen compounds	http://purl.obolibrary.org/obo/CHEBI_24471		3_STAR
CHEBI:61469	biolink:ChemicalSubstance	polyanionic polymer	A polymer, composed of polyanion macromolecules.		hp.json	polyanions|polyanion	http://purl.obolibrary.org/obo/CHEBI_61469		3_STAR
GO:0060800	biolink:BiologicalProcess	regulation of cell differentiation involved in embryonic placenta development	Any process that modulates the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state.		hp.json		http://purl.obolibrary.org/obo/GO_0060800		
UBERON:0003821	biolink:AnatomicalEntity	metapodium bone	A bone of the metapodial skeleton.	EMAPA:37284|MA:0000301	hp.json	metacarpal/metatarsal|metacarpal or metatarsal bone|metapodium bone|metapodial bone|metacarpal/metatarsal bone|metapodi bone	http://purl.obolibrary.org/obo/UBERON_0003821		
UBERON:0003822	biolink:AnatomicalEntity	forelimb stylopod	The part of the forelimb between pectoral region and the elbow, corresponding to the humerus.	VHOG:0000343|EMAPA:17424|VSAO:0005057|FMA:24890|galen:Arm|MA:0000035|EHDAA2:0002112|EHDAA:6234|MESH:D001132|AAO:0000199|NCIT:C32141|UMLS:C0446516|EHDAA:4186|OpenCyc:Mx4rvVj0Z5wpEbGdrcN5Y29ycA	hp.json	upper arm|fore propodium|stylopod of forelimb|brachium|proximal segment of free upper limb|forelimb stylopodial element|stylopod of arm|regio brachialis|forelimb propodium|wing stylopod|forelimb stylopodium|brachial region|arm	http://purl.obolibrary.org/obo/UBERON_0003822		pheno_slim
UBERON:0003820	biolink:AnatomicalEntity	prostate bud	A region of the fetal urogenital sinus epithelium destined to become the prostate[GO].	EMAPA:36141	hp.json	prostate ductal progenitor|prostate primordium|prostatic bud|prostate gland bud	http://purl.obolibrary.org/obo/UBERON_0003820		
GO:0060806	biolink:BiologicalProcess	negative regulation of cell differentiation involved in embryonic placenta development	Any process that decreases the rate, frequency or extent of cell differentiation that contributes to the progression of the placenta over time, from its initial condition to its mature state.		hp.json		http://purl.obolibrary.org/obo/GO_0060806		
UBERON:0015870	biolink:AnatomicalEntity	lymph node of head	A lymph node that is part of a head.	FMA:61212	hp.json		http://purl.obolibrary.org/obo/UBERON_0015870		
UBERON:0001228	biolink:AnatomicalEntity	renal papilla	Tip of renal pyramid projecting into a minor calyx.	EMAPA:35727|MESH:D007679|UMLS:C0022666|NCIT:C33460|FMA:15622|galen:RenalPapilla|MA:0002730|BTO:0003925	hp.json	kidney papilla	http://purl.obolibrary.org/obo/UBERON_0001228		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0003889	biolink:AnatomicalEntity	fallopian tube	Initial section of the oviduct through which the ova pass from the ovary to the uterus.	EV:0100112|UMLS:C0015560|CALOHA:TS-0732|OpenCyc:Mx4rvViVeZwpEbGdrcN5Y29ycA|MESH:D005187|EHDAA2:0000504|galen:FallopianTube|SCTID:181463001|EMAPA:18984|EMAPA:35660|GAID:365|NCIT:C12403|FMA:18245|Wikipedia:Fallopian_tube|MA:0000385	hp.json	female paramesonephric duct|salpinges|uterine tube (sensu Mammalia)|salpinx|tuba uterina|mammalian oviduct|fallopian tubes|tuba uterina|mammalian oviduct|paramesonephric duct of female	http://purl.obolibrary.org/obo/UBERON_0003889		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0001229	biolink:AnatomicalEntity	renal corpuscle	The structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron.	EMAPA:35726|CALOHA:TS-1317|BTO:0000333|EV:0100385|FMA:15625|UMLS:C0227635|ZFA:0005281|EMAPA:28236|TAO:0005281|VHOG:0001262|NCIT:C33456|MA:0000376	hp.json	kidney corpuscle|corpusculum renis|corpusculum renale|Malpighian corpuscle|Malphigian corpuscle|cortical renal corpuscle	http://purl.obolibrary.org/obo/UBERON_0001229		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
HP:0032553	biolink:PhenotypicFeature	Weak pulse	A diminution in the amplitude (strength) of the pulse such that the examiner has difficulty feeling the pulse.		hp.json		http://purl.obolibrary.org/obo/HP_0032553		
UBERON:0015875	biolink:AnatomicalEntity	heel	The part of the foot that is the projection of the calcaneus.	MESH:D006365|FMA:24994	hp.json	regio calcanea|calcaneal region|heel region	http://purl.obolibrary.org/obo/UBERON_0015875		
PATO:0001898	biolink:NamedThing	increased circumference	A circumference which is relatively high.		hp.json		http://purl.obolibrary.org/obo/PATO_0001898		value_slim
HP:0032552	biolink:PhenotypicFeature	Abnormal pulse	An anomaly of the rhythmic throbbing of an artery that reflects the widening of the artery as blood flows through it and is caused by successive contractions of the heart.		hp.json		http://purl.obolibrary.org/obo/HP_0032552		
HP:0032555	biolink:PhenotypicFeature	Bounding pulse	Increased amplitude (strength) of the pulse.		hp.json		http://purl.obolibrary.org/obo/HP_0032555		
HP:0032554	biolink:PhenotypicFeature	Absent pulse	The pulsation of an artery where the pulse is taken (e.g. the radial artery at the wrist) cannot be detected on physical examination.		hp.json		http://purl.obolibrary.org/obo/HP_0032554		
UBERON:0015871	biolink:AnatomicalEntity	facial lymph node	Any of the lymph nodes that are part of a face.	FMA:61222	hp.json	buccal lymph node	http://purl.obolibrary.org/obo/UBERON_0015871		
HP:0032551	biolink:PhenotypicFeature	Hemorrhoids	Enlarged, bulging blood vessels in and around the anus often associated with rectal bleeding, itching, and pain.		hp.json	Haemorrhoids|Piles	http://purl.obolibrary.org/obo/HP_0032551		
PATO:0001899	biolink:NamedThing	decreased circumference	A circumference which is relatively low.		hp.json		http://purl.obolibrary.org/obo/PATO_0001899		value_slim
UBERON:0015873	biolink:AnatomicalEntity	heel skin	A zone of skin that is part of a heel.	EMAPA:37354|MA:0003104	hp.json	skin of heel	http://purl.obolibrary.org/obo/UBERON_0015873		
HP:0032550	biolink:PhenotypicFeature	Howell-Jolly bodies	Howell-Jolly bodies are small, intra-erythrocytic remnants of erythrocyte nuclei. These inclusions are solitary in each erythrocyte and strongly basophilic. These are often confused with overlying platelets, but can be distinguished by the presence of a halo around overlying platelets.		hp.json		http://purl.obolibrary.org/obo/HP_0032550		
UBERON:0003890	biolink:AnatomicalEntity	Mullerian duct	Paired ducts of the embryo that run down the lateral sides of the urogenital ridge and terminate at the mullerian eminence in the primitive urogenital sinus. In the female, they will develop to form the fallopian tubes, uterus, and the upper portion of the vagina; in the male, they are lost. These ducts are made of tissue of mesodermal origin[WP]. develops either by lengthwise splitting of the archinephric duct (in chondrichthyans and some amphibians) or by a elongated invagination of the coelomic epithelium (other vertebrates) In males, the oviducts regress. The cranial end of the oviduct maintains an opening into the coelom (which primitively may have been the anteriormost coelomic funnels connecting the nephrocoel with the coelom). This opening is the ostium tubae[USM].	NCIT:C13260|VHOG:0001199|EMAPA:27665|GAID:1309|RETIRED_EHDAA2:0001399|SCTID:308802006|XAO:0000330|Wikipedia:Paramesonephric_duct|MESH:D009095|EHDAA2:0004048|UMLS:C0026732|AAO:0010141	hp.json	paramesonephric duct|Müllerian duct|early paramesonephric duct|ductus paramesonephricus|Muellerian duct	http://purl.obolibrary.org/obo/UBERON_0003890		pheno_slim
PATO:0001890	biolink:NamedThing	tripartite	A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being divided into three branches.		hp.json	trifurcate	http://purl.obolibrary.org/obo/PATO_0001890		value_slim|cell_quality
UBERON:0003891	biolink:AnatomicalEntity	stroma	Connective, non-functional supportive framework of a biological cell, tissue, or organ. Contrast with parenchyma.	UMLS:C0927195|NCIT:C67387|FMA:81494	hp.json	stromal connective tissue	http://purl.obolibrary.org/obo/UBERON_0003891		grouping_class
HP:0032557	biolink:PhenotypicFeature	History of bone marrow transplant	A past medical history of hematopoietic stem cell transplantation involving myeloablative chemoradiotherapy followed by stem cell rescue with autologous or human leukocyte antigen (HLA)-matched stem cells derived from a donor.		hp.json	Status post haematopoietic stem cell transplantation|Status post hematopoietic stem cell transplantation	http://purl.obolibrary.org/obo/HP_0032557		
PATO:0001894	biolink:NamedThing	phenotypic sex	An organismal quality inhering in a bearer by virtue of the bearer's physical expression of sexual characteristics.		hp.json		http://purl.obolibrary.org/obo/PATO_0001894		attribute_slim
HP:0032556	biolink:PhenotypicFeature	Circumoral cyanosis	Persistent blue color of the skin that surrounds the mouth.		hp.json	Bluish around mouth	http://purl.obolibrary.org/obo/HP_0032556		
PATO:0001891	biolink:NamedThing	ovate	A spheroid quality inhering in a bearer by virtue of the bearer's exhibiting a continuous convex surface with an axis of symmetry and one axis longer than the other; egg-shaped.		hp.json	egg-shaped|ovoid|oval|eccentric	http://purl.obolibrary.org/obo/PATO_0001891		value_slim|mpath_slim|cell_quality
HP:0032559	biolink:PhenotypicFeature	Short sperm flagella	Sperm cells with abnormally short flagella.		hp.json		http://purl.obolibrary.org/obo/HP_0032559		
HP:0032558	biolink:PhenotypicFeature	Absent sperm flagella	Sperm cells lacking flagella.		hp.json		http://purl.obolibrary.org/obo/HP_0032558		
UBERON:0001235	biolink:AnatomicalEntity	adrenal cortex	The thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone.	NCIT:C12396|MAT:0000494|BTO:0000045|EMAPA:18427|GAID:447|MA:0000118|CALOHA:TS-0015|FMA:15632|AAO:0011009|UMLS:C0001613|VHOG:0001481|MESH:D000302|XAO:0000165|EFO:0000237|EV:0100136	hp.json	cortex glandulae suprarenalis|suprarenal cortex|cortex (glandula suprarenalis)|cortex of suprarenal gland|suprarenal|cortex glandulae suprarenalis|adrenal gland cortex|cortex of adrenal gland	http://purl.obolibrary.org/obo/UBERON_0001235		pheno_slim|efo_slim|uberon_slim
UBERON:0003898	biolink:AnatomicalEntity	skeletal muscle tissue of trunk	A portion of skeletal muscle tissue in the trunk.	SCTID:244848007	hp.json	skeletal muscle of torso|skeletal muscle tissue of trunk|skeletal muscle tissue of torso|trunk skeletal muscle|torso skeletal muscle|torso skeletal muscle tissue|trunk skeletal muscle tissue	http://purl.obolibrary.org/obo/UBERON_0003898		
UBERON:0001234	biolink:AnatomicalEntity	left adrenal gland	An adrenal gland that is in the left side of the abdomen.	EMAPA:37356|NCIT:C49322|FMA:15630|UMLS:C0229560|MA:0000718	hp.json	glandula suprarenalis sinister|left suprarenal gland	http://purl.obolibrary.org/obo/UBERON_0001234		
UBERON:0003897	biolink:AnatomicalEntity	axial muscle	One of the skeletal muscles of the head and neck, spine, and ribs.	MA:0003153|TAO:0001954|EMAPA:18167|RETIRED_EHDAA2:0000160|EHDAA:5982	hp.json		http://purl.obolibrary.org/obo/UBERON_0003897		pheno_slim
UBERON:0001236	biolink:AnatomicalEntity	adrenal medulla	The inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine.	BTO:0000049|NCIT:C12397|MAT:0000495|CALOHA:TS-0018|AAO:0011010|MA:0000119|VHOG:0001378|EMAPA:18428|FMA:15633|UMLS:C0001629|XAO:0000166|EV:0100137|GAID:451|EFO:0000852|MESH:D019439	hp.json	chromaffin cells|medulla of adrenal gland|medulla glandulae suprarenalis|suprarenal medulla|medulla of glandula suprarenalis|medulla (glandula suprarenalis)|adrenal gland medulla|medulla of suprarenal gland|adrenal central medulla	http://purl.obolibrary.org/obo/UBERON_0001236		pheno_slim|efo_slim|uberon_slim
GO:0060837	biolink:BiologicalProcess	blood vessel endothelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels.		hp.json		http://purl.obolibrary.org/obo/GO_0060837		
UBERON:0003894	biolink:AnatomicalEntity	liver primordium	A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum.	UMLS:C0734013|EHDAA2:0000744|ZFA:0000124|UMLS:C1514451|EHDAA:973|BTO:0003391|TAO:0000124|EFO:0003428|XAO:0003266|NCIT:C34277|AAO:0011058|EFO:0002577|EMAPA:16847	hp.json	hepatic plate|primordium of the liver|liver bud|liver endoderm|embryological hepatic plate	http://purl.obolibrary.org/obo/UBERON_0003894		efo_slim|vertebrate_core|pheno_slim
UBERON:0001231	biolink:AnatomicalEntity	nephron tubule	An epithelial tube that is part of the nephron, the functional part of the kidney.	BTO:0000343|UMLS:C0022674|MESH:D007684|NCIT:C49274|GAID:433|MA:0000377|EMAPA:27782|ZFA:0001287|CALOHA:TS-1262|TAO:0001287|EV:0100387|FMA:15627|EFO:0003666	hp.json	tubulus renalis|kidney tubule|renal tubule|uriniferous tubule	http://purl.obolibrary.org/obo/UBERON_0001231		human_reference_atlas|efo_slim|uberon_slim|vertebrate_core|pheno_slim
UBERON:0001230	biolink:AnatomicalEntity	glomerular capsule	A cup-like sac at the expanded beginning of a tubular component of a nephron that contains the glomerulus.	TAO:0005310|TAO:0005254|UMLS:C0524448|BTO:0002297|EMAPA:27973|AAO:0010526|KUPO:0001001|EMAPA:28257|NCIT:C32225|MA:0001660|ZFA:0005310|ZFA:0005254|FMA:15626	hp.json	Muellerian capsule|Bowman's capsule|Mueller capsule|Bowmans capsule|Bowman's capsule|renal glomerular capsule|capsula glomerularis|pronephric glomerular capsule|Malphigian capsule|capsula glomeruli|Malpighian capsule	http://purl.obolibrary.org/obo/UBERON_0001230		uberon_slim|vertebrate_core|pheno_slim
UBERON:0003895	biolink:AnatomicalEntity	hypaxial myotome region	Portion of myotome that is ventral to the horizontal septum.	TAO:0001085|ZFA:0001085	hp.json	body wall muscle|hypaxial myotome region	http://purl.obolibrary.org/obo/UBERON_0003895		
UBERON:0001233	biolink:AnatomicalEntity	right adrenal gland	An adrenal gland that is in the right side of the abdomen.	UMLS:C0229559|MA:0000719|FMA:15629|EMAPA:37357|NCIT:C49325	hp.json	glandula suprarenalis dexter|right suprarenal gland	http://purl.obolibrary.org/obo/UBERON_0001233		
UBERON:0001232	biolink:AnatomicalEntity	collecting duct of renal tubule	The collecting duct is a portion of the nephron through which water flows, moving passively down its concentration gradient.	EMAPA:28407|BTO:0000761|ZFA:0005294|MESH:D007685|EV:0100391|CALOHA:TS-0860|GAID:434|TAO:0005294|FMA:15628|MA:0000371	hp.json	junctional tube|tubulus renalis arcuatus|tubulus renalis colligens|kidney collecting duct|renal collecting tubule|ureteric tree|collecting tubule|collecting duct system|kidney collecting tubule|arcuate renal tubule|collecting duct	http://purl.obolibrary.org/obo/UBERON_0001232		human_reference_atlas|uberon_slim|vertebrate_core|pheno_slim
UBERON:0003893	biolink:AnatomicalEntity	capsule	A cover or envelope partly or wholly surrounding a structure. Examples: egg shell, articular capsules, renal capsules[WP].	EHDAA:4739|FMA:85272|galen:Capsule|EHDAA:9061	hp.json		http://purl.obolibrary.org/obo/UBERON_0003893		non_informative|grouping_class
UBERON:0001217	biolink:AnatomicalEntity	ileal vein	The veins that drain blood from the ileum into the superior mesenteric vein.	NCIT:C53046|EMAPA:37149|MA:0002140|FMA:15405|UMLS:C1301431	hp.json		http://purl.obolibrary.org/obo/UBERON_0001217		human_reference_atlas
UBERON:0001216	biolink:AnatomicalEntity	jejunal vein	A tributary of the superior mesenteric vein that drains the jejunum.	MA:0002153|FMA:15402|EMAPA:37160	hp.json	venae jejunales	http://purl.obolibrary.org/obo/UBERON_0001216		human_reference_atlas
HP:0032564	biolink:PhenotypicFeature	Ileitis	Inflammation of the ileum.		hp.json	Inflammation of the ileum	http://purl.obolibrary.org/obo/HP_0032564		
HP:0032563	biolink:PhenotypicFeature	Dacryocytosis	Presence of teardrop-shaped red blood cells.		hp.json	Tear-drop shaped erythrocytes|Dacryocytes	http://purl.obolibrary.org/obo/HP_0032563		
GO:0045202	biolink:CellularComponent	synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.	Wikipedia:Chemical_synapse|NIF_Subcellular:sao914572699	hp.json	electrotonic synapse|synaptic junction|mixed synapse	http://purl.obolibrary.org/obo/GO_0045202		goslim_drosophila|goslim_mouse|goslim_agr|goslim_synapse|goslim_pir|goslim_flybase_ribbon
HP:0032566	biolink:PhenotypicFeature	Oval macrocytosis	Enlarged, oval-shaped erythrocytes (red blood cells).		hp.json		http://purl.obolibrary.org/obo/HP_0032566		
HP:0032565	biolink:PhenotypicFeature	Vaginal mucosal ulceration			hp.json		http://purl.obolibrary.org/obo/HP_0032565		
GO:0045200	biolink:BiologicalProcess	establishment of neuroblast polarity	The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.		hp.json	establishment of neuroblast cell polarity	http://purl.obolibrary.org/obo/GO_0045200		
HP:0032560	biolink:PhenotypicFeature	Coiled sperm flagella	Sperm cells whose flagella are twisted (coiled).		hp.json		http://purl.obolibrary.org/obo/HP_0032560		
UBERON:0015860	biolink:AnatomicalEntity	visceral abdominal lymph node		FMA:66178	hp.json		http://purl.obolibrary.org/obo/UBERON_0015860		
HP:0032562	biolink:PhenotypicFeature	Tapered sperm head	Sperm with cigar-shaped heads that gradually dimish in diameter (taper).		hp.json		http://purl.obolibrary.org/obo/HP_0032562		
HP:0032561	biolink:PhenotypicFeature	Microcephalic sperm head	Decreased size of the head of sperm.		hp.json	Small-head sperm	http://purl.obolibrary.org/obo/HP_0032561		
HP:0032568	biolink:PhenotypicFeature	Urinary mulberry cells	Distal tubular epithelial cells in which globotriaosylceramide (Gb3) has accumulated. they are the characteristic feature of Fabry disease. Urinary mulberry bodies are a component of mulberry cells that can be distinguished easily from fat particles by their inner lamellar appearance.		hp.json		http://purl.obolibrary.org/obo/HP_0032568		
HP:0032567	biolink:PhenotypicFeature	Lipiduria	An increased lipid content in the urine.		hp.json	Urinary lipid excretion	http://purl.obolibrary.org/obo/HP_0032567		
HP:0032569	biolink:PhenotypicFeature	Temporal bossing			hp.json		http://purl.obolibrary.org/obo/HP_0032569		
UBERON:0003887	biolink:AnatomicalEntity	intraembryonic coelom	The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.	UMLS:C1512940|VHOG:0000316|EHDAA:251|NCIT:C34195|Wikipedia:Intraembryonic_coelom|EMAPA:16088	hp.json	somatic coelom|somatic coelom	http://purl.obolibrary.org/obo/UBERON_0003887		pheno_slim
UBERON:0001224	biolink:AnatomicalEntity	renal pelvis	A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP].	EMAPA:17948|GAID:426|UMLS:C0227666|galen:RenalPelvis|MESH:D007682|FMA:15575|NCIT:C12887|CALOHA:TS-2230|MA:0000374	hp.json	pyelum|p. renallis|kidney pelvis|pelvis of ureter	http://purl.obolibrary.org/obo/UBERON_0001224		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0001223	biolink:AnatomicalEntity	left ureter	An ureter that is part of a left side of organism [Automatically generated definition].	NCIT:C49324|UMLS:C0227683|EMAPA:37372|FMA:15572|MA:0001684	hp.json		http://purl.obolibrary.org/obo/UBERON_0001223		
UBERON:0003885	biolink:AnatomicalEntity	mesometrium	A mesentery that is part of a uterus [Automatically generated definition].	FMA:19816|MA:0002931|EMAPA:35562	hp.json	mesentery of uterus	http://purl.obolibrary.org/obo/UBERON_0003885		
UBERON:0001225	biolink:AnatomicalEntity	cortex of kidney	Outer cortical portion of the kidney, between the renal capsule and the renal medulla.	MA:0000372|CALOHA:TS-0503|galen:CortexOfKidney|NCIT:C12739|BTO:0001166|MESH:D007672|GAID:424|EMAPA:17952|UMLS:C0022655|FMA:15581	hp.json	renal cortex|kidney cortex|cortex renalis	http://purl.obolibrary.org/obo/UBERON_0001225		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0003886	biolink:AnatomicalEntity	future coelemic cavity lumen	An anatomical cavity that has the potential to develop into a coelemic cavity lumen.		hp.json	body cavity precursor|future coelomic cavity lumen	http://purl.obolibrary.org/obo/UBERON_0003886		non_informative|grouping_class
UBERON:0001222	biolink:AnatomicalEntity	right ureter	An ureter that is part of a right side of organism [Automatically generated definition].	EMAPA:37373|UMLS:C0227682|MA:0001685|FMA:15571|NCIT:C49327	hp.json		http://purl.obolibrary.org/obo/UBERON_0001222		
UBERON:0001221	biolink:AnatomicalEntity	transversus abdominis muscle	The lateral abdominal wall muscle that is deep to the internal oblique.	MA:0002396|EHDAA2:0002078|UMLS:C0224378|EHDAA:8254|NCIT:C53179|FMA:15570|VHOG:0000845|EMAPA:18165	hp.json	transversis abdominus|transversus abdominus muscle|transverse abdominal|transversus abdominis|transversus|transversalis muscle|transverse abdominal muscle|transverse abdominus|musculus transversus abdominis|transverse abdominal|transverse abdominis|musculus transversus abdominis|transversalis|transversus abdominis|transversus abdominus	http://purl.obolibrary.org/obo/UBERON_0001221		uberon_slim|organ_slim
UBERON:0001209	biolink:AnatomicalEntity	serosa of large intestine	A serous membrane that is part of a large intestine [Automatically generated definition].	UMLS:C1517727|EMAPA:37557|NCIT:C32929|FMA:14975|MA:0001546	hp.json	visceral peritoneum of large intestine|large intestine serous membrane|tunica serosa intestini crassi|large intestine serosa|serous coat of large intestine|serous membrane of large intestine|large intestinal serosa	http://purl.obolibrary.org/obo/UBERON_0001209		
GO:1901706	biolink:BiologicalProcess	mesenchymal cell differentiation involved in bone development	The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of bone as it progresses from its formation to the mature state.		hp.json		http://purl.obolibrary.org/obo/GO_1901706		
UBERON:0001206	biolink:AnatomicalEntity	serosa of small intestine	A serous membrane that is part of a small intestine [Automatically generated definition].	FMA:14938|EMAPA:37561|MA:0001558	hp.json	small bowel serous membrane|tunica serosa intestini tenuis|small intestinal serosa|small intestine serosa|tunica serosa (intestinum tenue)|visceral peritoneum of small intestine|serous membrane of small bowel|small intestine serous membrane|small bowel serosa|serous coat of small intestine|serosa of small bowel|serous membrane of small intestine	http://purl.obolibrary.org/obo/UBERON_0001206		
UBERON:0003869	biolink:AnatomicalEntity	presumptive ganglion	A presumptive structure that has the potential to develop into a ganglion.		hp.json		http://purl.obolibrary.org/obo/UBERON_0003869		
UBERON:0001205	biolink:AnatomicalEntity	submucosa of small intestine	Submucosal tissue in the small intestines.	MA:0001562|FMA:14934|NCIT:C33572|EMAPA:37564|BTO:0002112|UMLS:C0227268	hp.json	submucosa of small bowel|tela submucosa intestini tenuis|small bowel submucosa|tela submucosa (intestinum tenue)|small intestinal submucosa|small intestine submucosa	http://purl.obolibrary.org/obo/UBERON_0001205		uberon_slim
UBERON:0003867	biolink:AnatomicalEntity	distal phalanx of pes	A distal phalanx that is part of a pedal digit [Automatically generated definition].	NCIT:C52783|FMA:75830|MA:0001380|EMAPA:37310|UMLS:C0224026	hp.json	ungual phalanx of foot|phalanx distalis pedis|foot distal phalanx|ungual phalanx of hindlimb|terminal phalanx of foot|distal phalanx of toe|distal pedal phalanx|distal phalanx of foot|terminal phalanx of hindlimb	http://purl.obolibrary.org/obo/UBERON_0003867		pheno_slim
GO:1901701	biolink:BiologicalProcess	cellular response to oxygen-containing compound	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.		hp.json	cellular response to oxygen molecular entity	http://purl.obolibrary.org/obo/GO_1901701		
UBERON:0001208	biolink:AnatomicalEntity	submucosa of large intestine	A submucosa that is part of a large intestine [Automatically generated definition].	FMA:14970|NCIT:C32930|UMLS:C0734204|MA:0002690|BTO:0002111|EMAPA:37560	hp.json	large intestinal submucosa|tela submucosa intestini crassi|large intestine submucosa|submucous layer of large intestine	http://purl.obolibrary.org/obo/UBERON_0001208		
UBERON:0001207	biolink:AnatomicalEntity	mucosa of large intestine	A mucosa that is part of a large intestine [Automatically generated definition].	MA:0002688|FMA:14969|NCIT:C32926|CALOHA:TS-2106|UMLS:C0734203|EMAPA:35467	hp.json	large intestine organ mucosa|large intestine mucosa|organ mucosa of large intestine|large intestine mucosa of organ|mucous membrane of large intestine|mucosa of organ of large intestine|large intestinal mucosa|large intestine mucous membrane|tunica mucosa intestini crassi	http://purl.obolibrary.org/obo/UBERON_0001207		
UBERON:0003868	biolink:AnatomicalEntity	proximal phalanx of pes	A proximal phalanx that is part of a pedal digit [Automatically generated definition].	MA:0001387|EMAPA:37312|UMLS:C0224020|FMA:75828|NCIT:C52785	hp.json	phalanx proximalis pedis|proximal pedal phalanx|foot proximal phalanx|proximal phalanx of foot|proximal phalanx of foot digit|proximal phalanx of pes|proximal phalanx of toe|proximal phalanx of hind digit	http://purl.obolibrary.org/obo/UBERON_0003868		pheno_slim
HP:0032575	biolink:PhenotypicFeature	Decreased circulating 12-HETE	A reduction in the concentration of 12-HETE in the blood circulation, a metabolite of arachidonic acid.		hp.json	Decreased circulating 12-Hydroxyeicosatetraenoic acid concentration	http://purl.obolibrary.org/obo/HP_0032575		
UBERON:0015854	biolink:AnatomicalEntity	interpedicular line	An anatomical line that connects two successive vertebral pedicles. The length of this line is known as the interpedicular distance.		hp.json	interpedicular distance|inter-vertebral-pedicle line	http://purl.obolibrary.org/obo/UBERON_0015854		
GO:1901700	biolink:BiologicalProcess	response to oxygen-containing compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.		hp.json	response to oxygen molecular entity	http://purl.obolibrary.org/obo/GO_1901700		
GO:0045216	biolink:BiologicalProcess	cell-cell junction organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.		hp.json	cell-cell junction biogenesis|intercellular junction assembly and maintenance|cell-cell junction organisation|cell-cell junction assembly and maintenance	http://purl.obolibrary.org/obo/GO_0045216		
HP:0032574	biolink:PhenotypicFeature	Elevated urinary uridine level	Increased levels of urinary uridine, a ribonucleoside composed of a molecule of uracil attached to a ribofuranose moiety via a beta-N1 glycosidic bond.		hp.json	Elevated uridine in urine	http://purl.obolibrary.org/obo/HP_0032574		
UBERON:0015853	biolink:AnatomicalEntity	dental pulp of median incisor tusk	A dental pulp that is part of a narwhal tusk.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015853		
HP:0032577	biolink:PhenotypicFeature	Clonal T cell receptor rearrangement	Presence of a predominant T cell clone. In PCR-based assays, this finding is inferred on the basis of one or two prominent bands within a valid size range. In NGS-based assays, this finding is inferred on the basis of a high number of reads that map to a single T cell receptor clone.		hp.json		http://purl.obolibrary.org/obo/HP_0032577		
GO:0045214	biolink:BiologicalProcess	sarcomere organization	The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.		hp.json	sarcomere organisation|sarcomere alignment	http://purl.obolibrary.org/obo/GO_0045214		
HP:0032576	biolink:PhenotypicFeature	Intracellular accumulation of Dol-PP-GlcNAc2Man5	Intracellular accumulation of the lipid-linked oligosaccharide intermediate Man5GlcNAc2-PP-dolichol.		hp.json		http://purl.obolibrary.org/obo/HP_0032576		
UBERON:0015850	biolink:AnatomicalEntity	upper left incisor tusk			hp.json		http://purl.obolibrary.org/obo/UBERON_0015850		
HP:0032571	biolink:PhenotypicFeature	Increased oocyte death	An increase in death of oocytes, the female germ cell (egg cell), which can be observed clinically in the setting of in vitro fertilization.		hp.json		http://purl.obolibrary.org/obo/HP_0032571		
HP:0032570	biolink:PhenotypicFeature	Pontine ischemic lacunes	Lacunes are infarcts less than 15 mm in diameter in the cortical white matter or in the corona radiata, internal capsule, centrum semiovale, thalamus, basal ganglia, or pons.		hp.json	Pontine ischaemic lacunes	http://purl.obolibrary.org/obo/HP_0032570		
HP:0032573	biolink:PhenotypicFeature	Elevated urinary cytidine	Increased levels of urinary cytidine, a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N1 glycosidic bond.		hp.json		http://purl.obolibrary.org/obo/HP_0032573		
UBERON:0015852	biolink:AnatomicalEntity	narwhal tusk	A upper jaw incisor that protrudes prominently from the mouth as a single median tusk, found in narwhals.		hp.json	median incisor tusk	http://purl.obolibrary.org/obo/UBERON_0015852		
UBERON:0015851	biolink:AnatomicalEntity	upper right incisor tusk			hp.json		http://purl.obolibrary.org/obo/UBERON_0015851		
HP:0032572	biolink:PhenotypicFeature	Abnormal urinary nucleobase concentration	A deviation from the normal level of a nucleobase in the urine. Nucleobases are nitrogen-containing biological compounds that form nucleosides: adenine (A), cytosine (C), guanine (G), thymine (T), and uracil (U).		hp.json		http://purl.obolibrary.org/obo/HP_0032572		
HP:0032579	biolink:PhenotypicFeature	Vascular hamartoma	A benign focal growth composed of vascular tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0032579		
UBERON:0015847	biolink:AnatomicalEntity	upper left incisor tooth	A upper jaw incisor that is in_the_left_side_of a dentition.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015847		
UBERON:0015846	biolink:AnatomicalEntity	incisor mesenchyme	An odontogenic mesenchyme that is part of a incisor tooth.	EMAPA:32894|MA:0003229	hp.json		http://purl.obolibrary.org/obo/UBERON_0015846		
HP:0032578	biolink:PhenotypicFeature	Third ventricle colloid cyst	An epithelial lined cyst filled with gelatinous material. The gelatinous material commonly contains mucin, old blood, cholesterol, and ions. Most colloid cysts identified are currently asymptomatic and identified incidentally on imaging. When a colloid cyst does cause issues, it most commonly causes obstructive hydrocephalus.		hp.json		http://purl.obolibrary.org/obo/HP_0032578		
UBERON:0015849	biolink:AnatomicalEntity	canine tusk	An cuspid tooth that protrudes beyond the mouth.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015849		
UBERON:0015848	biolink:AnatomicalEntity	incisor tusk	An incisor tooth that protrudes beyond the mouth.		hp.json		http://purl.obolibrary.org/obo/UBERON_0015848		
UBERON:0001213	biolink:AnatomicalEntity	intestinal villus	The tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold.	ZFA:0005125|TAO:0005125|FMA:15072|EMAPA:35784|BTO:0003121|UMLS:C1519988|NCIT:C33874|MA:0001563	hp.json	villi intestinales|villus intestinalis (intestinum tenue)|intestinal villi|enteric villi|villi intestinales|intestinal villus layer|enteric villus|small intestine villus|villus|enteric villous	http://purl.obolibrary.org/obo/UBERON_0001213		pheno_slim|uberon_slim|vertebrate_core
UBERON:0001212	biolink:AnatomicalEntity	duodenal gland	A compound tubular submucosal gland found in that portion of the duodenum which is above the hepatopancreatic sphincter (Sphincter of Oddi). The main function of these glands is to produce a mucus-rich alkaline secretion (containing bicarbonate)[WP].	MA:0001551|FMA:15060|MESH:D002011|NCIT:C13010|BTO:0002376|UMLS:C0006323|EMAPA:36522|GAID:314	hp.json	glandula duodenales|gland of Brunner|glandula duodenales Brunneri|submucosal gland of duodenum|Brunner's gland	http://purl.obolibrary.org/obo/UBERON_0001212		pheno_slim|uberon_slim|organ_slim
UBERON:0001215	biolink:AnatomicalEntity	inferior mesenteric vein	A blood vessel that drains blood from the large intestine that usually terminates when reaching the splenic vein, which goes on to form the portal vein with the superior mesenteric vein (SMV). Anatomical variations include the IMV draining into the confluence of the SMV and splenic vein and the IMV draining in the SMV. The IMV lies to the right of the similarly name artery, the inferior mesenteric artery, which originates from the abdominal aorta. [WP,unvetted].	MA:0002178|UMLS:C0226754|NCIT:C32782|EHDAA:8712|EHDAA2:0000819|FMA:15391|SCTID:281055007|VHOG:0001118|OpenCyc:Mx4rvcV53ZwpEbGdrcN5Y29ycA|BTO:0002782|Wikipedia:Inferior_mesenteric_vein|EMAPA:18642	hp.json	vena mesenterica inferior|lower mesenteric vein|vena mesenterica inferior	http://purl.obolibrary.org/obo/UBERON_0001215		human_reference_atlas|uberon_slim
CHEBI:24433	biolink:ChemicalSubstance	group	A defined linked collection of atoms or a single atom within a molecular entity.		hp.json	Gruppe|grupos|grupo|groupe|Rest|group	http://purl.obolibrary.org/obo/CHEBI_24433		3_STAR
HP:0032580	biolink:PhenotypicFeature	Abnormal bulbus cordis morphology	Abnormal structure of the bulbus cordis, which is the single outflow tract of the heart during early embryogenesis.		hp.json		http://purl.obolibrary.org/obo/HP_0032580		
CHEBI:24432	biolink:ChemicalSubstance	biological role	A role played by the molecular entity or part thereof within a biological context.		hp.json	biological function	http://purl.obolibrary.org/obo/CHEBI_24432		3_STAR
CHEBI:24431	biolink:ChemicalSubstance	chemical entity	A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances.		hp.json	chemical entity	http://purl.obolibrary.org/obo/CHEBI_24431		3_STAR
UBERON:0003858	biolink:AnatomicalEntity	lower eyelid mesenchyme	Mesenchyme that is part of a developing lower eyelid [Automatically generated definition].	EHDAA2:0001017|VHOG:0001036|EMAPA:17833|EHDAA:9045	hp.json	mesenchyme of inferior eyelid|mesenchyme of lower eyelid|inferior eyelid mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003858		
UBERON:0003859	biolink:AnatomicalEntity	forelimb mesenchyme	Mesenchyme that is part of a developing forelimb [Automatically generated definition].	EMAPA:32628|VHOG:0001109	hp.json	mesenchyme of forelimb|superior member mesenchyme|wing mesenchyme|mesenchyme of superior member|mesenchyme of anteriormost limb|mesenchyme of upper extremity|mesenchyme of fore limb|wing mesenchyme|fore limb mesenchyme|upper extremity mesenchyme|anteriormost limb mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003859		
CHEBI:24436	biolink:ChemicalSubstance	guanidines	Any organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas.		hp.json		http://purl.obolibrary.org/obo/CHEBI_24436		3_STAR
UBERON:0003856	biolink:AnatomicalEntity	uncondensed odontogenic mesenchyme	Mesenchyme enclosed by a dental organ that gives rise to an odontogenic papilla.	ZFA:0005139|VHOG_RETIRED:0001444|TAO:0005139|MA:0003152|EMAPA:32891	hp.json	enamel organ mesenchyme|dental mesenchyme|dental organ mesenchyme|tooth enamel organ mesenchyme|tooth mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003856		vertebrate_core
UBERON:0003857	biolink:AnatomicalEntity	upper eyelid mesenchyme	Mesenchyme that is part of a developing upper eyelid [Automatically generated definition].	EHDAA2:0002117|EHDAA:9051|VHOG:0001093|EMAPA:17836	hp.json	mesenchyme of upper eyelid|mesenchyme of superior eyelid|superior eyelid mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003857		
HP:0032586	biolink:PhenotypicFeature	Renal interstitial plasma cell infiltration	Increased numbers of plasma cells in the interstitial tissues of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032586		
UBERON:0015843	biolink:AnatomicalEntity	molar enamel organ		EMAPA:32880|MA:0003228	hp.json		http://purl.obolibrary.org/obo/UBERON_0015843		
HP:0032585	biolink:PhenotypicFeature	Renal interstitial eosinophil infiltration	Increased numbers of eosinophils in the interstitial tissues of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032585		
UBERON:0015842	biolink:AnatomicalEntity	incisor enamel organ	A tooth enamel organ that is part of a incisor tooth.	EMAPA:32895|MA:0003227	hp.json		http://purl.obolibrary.org/obo/UBERON_0015842		
GO:0045224	biolink:BiologicalProcess	positive regulation of CD4 production	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.		hp.json	up regulation of CD4 biosynthetic process|positive regulation of CD4 anabolism|stimulation of CD4 biosynthetic process|up-regulation of CD4 biosynthetic process|activation of CD4 biosynthetic process|positive regulation of CD4 synthesis|positive regulation of CD4 formation|upregulation of CD4 biosynthetic process|positive regulation of CD4 biosynthetic process|positive regulation of CD4 biosynthesis	http://purl.obolibrary.org/obo/GO_0045224		
HP:0032588	biolink:PhenotypicFeature	Hand apraxia	Inability to perform purposeful (learned) movements with the hand upon command, even though the command is understood and there is a willingness to perform the movement. Hand apraxia includes the inability to grasp, pick up, and hold large and small objects.		hp.json	Lack of purposeful hand use	http://purl.obolibrary.org/obo/HP_0032588		
UBERON:0015844	biolink:AnatomicalEntity	molar dental papilla		MA:0003232|EMAPA:32882	hp.json	molar odontogenic papilla|molar tooth odontogenic papilla	http://purl.obolibrary.org/obo/UBERON_0015844		
GO:0045225	biolink:BiologicalProcess	negative regulation of CD4 production	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.		hp.json	downregulation of CD4 biosynthetic process|negative regulation of CD4 anabolism|down regulation of CD4 biosynthetic process|inhibition of CD4 biosynthetic process|negative regulation of CD4 synthesis|down-regulation of CD4 biosynthetic process|negative regulation of CD4 biosynthetic process|negative regulation of CD4 biosynthesis|negative regulation of CD4 formation	http://purl.obolibrary.org/obo/GO_0045225		
HP:0032587	biolink:PhenotypicFeature	Renal interstitial calcium oxalate	The presence of birefringent calcium- and oxalate deposits in interstitial cells of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032587		
GO:0045222	biolink:BiologicalProcess	CD4 biosynthetic process	The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions.		hp.json	CD4 anabolism|CD4 biosynthesis|CD4 synthesis|CD4 formation	http://purl.obolibrary.org/obo/GO_0045222		
HP:0032582	biolink:PhenotypicFeature	Renal interstitial foam cells	Accumulation of foam cells (FC) in the interstitium of the kidney. Renal FCs display phenotypic characteristics of macrophages and belong to the monocyte/macrophage lineage. Histologically, renal FCs are characterized by round cells with small nuclei and an abundant PAS-positive cytoplasm with lipid-containing vacuoles.		hp.json		http://purl.obolibrary.org/obo/HP_0032582		
HP:0032581	biolink:PhenotypicFeature	Abnormal renal insterstitial morphology	Any structural anomaly of the interstitium of the kidney. The renal interstitium is defined as the intertubular, extraglomerular, extravascular space of the kidney. It is bounded on all sides by tubular and vascular basement membranes and is filled with cells, extracellular matrix, and interstitial fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0032581		
GO:0045223	biolink:BiologicalProcess	regulation of CD4 production	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.		hp.json	regulation of CD4 formation|regulation of CD4 biosynthetic process|regulation of CD4 biosynthesis|regulation of CD4 anabolism|regulation of CD4 synthesis	http://purl.obolibrary.org/obo/GO_0045223		
HP:0032584	biolink:PhenotypicFeature	Renal interstitial neutrophil infiltration	Increased numbers of neutrophils in the interstitial tissues of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032584		
HP:0032583	biolink:PhenotypicFeature	Renal glomerular foam cells			hp.json		http://purl.obolibrary.org/obo/HP_0032583		
UBERON:0015839	biolink:AnatomicalEntity	molar epithelium		MA:0003224|EMAPA:32878	hp.json	epithelium of molar tooth|epithelium of molar	http://purl.obolibrary.org/obo/UBERON_0015839		
GO:0060840	biolink:BiologicalProcess	artery development	The progression of the artery over time, from its initial formation to the mature structure. An artery is a blood vessel that carries blood away from the heart to a capillary bed.		hp.json		http://purl.obolibrary.org/obo/GO_0060840		
GO:0060841	biolink:BiologicalProcess	venous blood vessel development	The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.		hp.json		http://purl.obolibrary.org/obo/GO_0060841		
GO:0060842	biolink:BiologicalProcess	arterial endothelial cell differentiation	The process in which a relatively unspecialized endothelial cell acquires specialized features of an arterial endothelial cell, a thin flattened cell that lines the inside surfaces of arteries.		hp.json		http://purl.obolibrary.org/obo/GO_0060842		
HP:0032589	biolink:PhenotypicFeature	Renal lymphocytic tubulitis	Infiltration of the renal tubular epithelium by lymphocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0032589		
GO:0060843	biolink:BiologicalProcess	venous endothelial cell differentiation	The process in which a relatively unspecialized endothelial cell acquires specialized features of a venous endothelial cell, a thin flattened cell that lines the inside surfaces of veins.		hp.json		http://purl.obolibrary.org/obo/GO_0060843		
UBERON:0015838	biolink:AnatomicalEntity	molar dental pulp		FMA:294469|MA:0003222|EMAPA:35576	hp.json		http://purl.obolibrary.org/obo/UBERON_0015838		
GO:0045229	biolink:BiologicalProcess	external encapsulating structure organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell.		hp.json	external encapsulating structure organisation|external encapsulating structure organization and biogenesis	http://purl.obolibrary.org/obo/GO_0045229		goslim_pir
UBERON:0015837	biolink:AnatomicalEntity	incisor dental pulp	A dental pulp that is part of a incisor tooth.	FMA:294459|EMAPA:35429|MA:0003221	hp.json		http://purl.obolibrary.org/obo/UBERON_0015837		
UBERON:0003865	biolink:AnatomicalEntity	distal phalanx of manus	A distal phalanx that is part of a finger [Automatically generated definition].	EMAPA:35393|FMA:75818|UMLS:C1269782|NCIT:C52784|MA:0001388	hp.json	distal manual phalanx|distal phalanx of finger|terminal phalanx of hand|distal phalanx of manual digit|phalanx distalis manus|distal phalanx of hand|hand distal phalanx|ungual phalanx of hand	http://purl.obolibrary.org/obo/UBERON_0003865		pheno_slim
UBERON:0001202	biolink:AnatomicalEntity	pyloric sphincter	A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP].	FMA:14916|NCIT:C33433|EMAPA:19251|VHOG:0001466|XAO:0000457|OpenCyc:Mx4rvly2ZZwpEbGdrcN5Y29ycA|AAO:0011093|MA:0002952|UMLS:C0227238	hp.json	pyloric valve	http://purl.obolibrary.org/obo/UBERON_0001202		pheno_slim|uberon_slim
UBERON:0001201	biolink:AnatomicalEntity	serosa of stomach	The outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum.	NCIT:C32662|SCTID:1353004|FMA:14914|EMAPA:35822|UMLS:C1517453|MA:0001626	hp.json	serous membrane of anatomical wall of ventriculus|serous coat of stomach|ventriculus anatomical wall serosa|stomach wall serosa|serous membrane of wall of ventriculus|wall of stomach serous membrane|ventriculus anatomical wall serous membrane|stomach wall serous membrane|wall of stomach serosa|serosa of stomach wall|serous membrane of gastric wall|serosa of stomach anatomical wall|tunica serosa gastricae|serous membrane of anatomical wall of stomach|gastric serosa|anatomical wall of stomach serosa|tunica serosa (gaster)|serous membrane of wall of stomach|stomach serosa|wall of ventriculus serosa|stomach anatomical wall serous membrane|gastric wall serosa|ventriculus wall serous membrane|serosa of ventriculus wall|serous membrane of ventriculus anatomical wall|serosa of wall of ventriculus|serous membrane of stomach wall|serosa of anatomical wall of ventriculus|visceral peritoneum of stomach|anatomical wall of ventriculus serous membrane|anatomical wall of ventriculus serosa|ventriculus wall serosa|stomach anatomical wall serosa|serosa of gastric wall|wall of ventriculus serous membrane|serous membrane of stomach anatomical wall|gastric wall serous membrane|serosa of wall of stomach|serosa of anatomical wall of stomach|anatomical wall of stomach serous membrane|serosa of ventriculus anatomical wall|serous membrane of ventriculus wall	http://purl.obolibrary.org/obo/UBERON_0001201		pheno_slim
UBERON:0003866	biolink:AnatomicalEntity	middle phalanx of pes	A middle phalanx that is part of a toe [Automatically generated definition].	MA:0001386|EMAPA:37311|FMA:75829	hp.json	phalanx media pedis|foot middle phalanx|middle pedal phalanx|middle phalanx of toe|middle phalanx of foot	http://purl.obolibrary.org/obo/UBERON_0003866		pheno_slim
UBERON:0001204	biolink:AnatomicalEntity	mucosa of small intestine	A mucosa that is part of a small intestine [Automatically generated definition].	EMAPA:35780|MA:0002686|BTO:0001259|FMA:14933|CALOHA:TS-0941|UMLS:C0227261|NCIT:C33568	hp.json	mucosa of small bowel|small bowel mucosa|mucosa of organ of small bowel|small bowel organ mucosa|small bowel mucous membrane|tunica mucosa (intestinum tenue)|organ mucosa of small intestine|small intestine mucosa of organ|mucous membrane of small intestine|mucosa of organ of small intestine|small intestine mucosa|small intestinal mucosa|small intestine organ mucosa|small intestine mucous membrane|tunica mucosa intestini tenuis|organ mucosa of small bowel|small bowel mucosa of organ|mucous membrane of small bowel	http://purl.obolibrary.org/obo/UBERON_0001204		
UBERON:0003863	biolink:AnatomicalEntity	pedal digit 5 phalanx	A phalanx that is part of a foot digit 5 [Automatically generated definition].	MA:0001385|EMAPA:19132|FMA:32902|UMLS:C1708088|NCIT:C52782	hp.json	phalanx of little toe|foot digit 5 phalanx|hind limb digit 5 phalanx|foot digit 5 digit long bone|long bone of digit of foot digit 5|phalanx of fifth toe|pedal digit V phalanx|phalanx of foot digit 5|foot digit 5 phalanx|phalanx of fifth digit of foot|digit long bone of foot digit 5|little toe phalanx|foot digit 5 long bone of digit	http://purl.obolibrary.org/obo/UBERON_0003863		pheno_slim
UBERON:0003864	biolink:AnatomicalEntity	middle phalanx of manus	A middle phalanx that is part of a finger [Automatically generated definition].	NCIT:C12863|MA:0001394|FMA:75817|EMAPA:37306|UMLS:C0223828	hp.json	phalanx media manus|middle phalanx of manual digit|middle manual phalanx|hand middle phalanx|middle phalanx of finger|middle phalanx of hand	http://purl.obolibrary.org/obo/UBERON_0003864		pheno_slim
UBERON:0003861	biolink:AnatomicalEntity	neural arch	Posterior part of a vertebra that consists of a pair of pedicles and a pair of laminae, and supports seven processes: four articular processes, two transverse processes one spinous process[WP]. ZFA: A neural arch encloses the neural canal and typically meets its partner to form a neural spine.	OpenCyc:Mx4rwKYHvZwpEbGdrcN5Y29ycA|TAO:0001066|UMLS:C0223076|AAO:0000725|VHOG:0001670|NCIT:C32138|EFO:0003618|FMA:11946|MA:0001453|ZFA:0001066	hp.json	arcus vertebrae|arcus vertebrae (vertebralis)|dorsal arcocentrum|arcus vertebra|arcus vertebrae|vertebra dorsal arch|vertebra neural arch	http://purl.obolibrary.org/obo/UBERON_0003861		pheno_slim|efo_slim|vertebrate_core
UBERON:0003862	biolink:AnatomicalEntity	pedal digit 4 phalanx	A phalanx that is part of a foot digit 4 [Automatically generated definition].	NCIT:C52781|MA:0001384|EMAPA:19130|UMLS:C1708086|FMA:32901	hp.json	pedal digit IV phalanx|hind limb digit 4 phalanx|foot digit 4 digit long bone|long bone of digit of foot digit 4|foot digit 4 phalanx|fourth toe phalanx|foot digit 4 phalanx|phalanx of foot digit 4|foot digit 4 long bone of digit|digit long bone of foot digit 4|phalanx of fourth toe	http://purl.obolibrary.org/obo/UBERON_0003862		pheno_slim
UBERON:0001200	biolink:AnatomicalEntity	submucosa of stomach	The fibrous connective tissue layer beneath the stomach mucosa.	MA:0002685|NCIT:C32663|EMAPA:35825|UMLS:C0227211|SCTID:52459002|BTO:0002110|FMA:14908	hp.json	stomach submucosa|submucous layer of stomach|tela submucosa gastricae|gastric submucosa|submucosa of ventriculus|tela submucosa (gaster)|ventriculus submucosa|tela submucosa ventriculi	http://purl.obolibrary.org/obo/UBERON_0001200		pheno_slim
UBERON:0003860	biolink:AnatomicalEntity	hindlimb mesenchyme	Mesenchyme that is part of a developing hindlimb [Automatically generated definition].	VHOG:0001074|EMAPA:32637	hp.json	mesenchyme of hind limb|mesenchyme of hindlimb|mesenchyme of lower extremity|lower extremity mesenchyme|hind limb mesenchyme|inferior member mesenchyme|mesenchyme of inferior member	http://purl.obolibrary.org/obo/UBERON_0003860		
UBERON:4200172	biolink:AnatomicalEntity	neck of humerus		NCIT:C33164|FMA:23356	hp.json	collum anatomicum (Humerus)|humeral neck|anatomic neck of humerus|collum anatomicum humeri	http://purl.obolibrary.org/obo/UBERON_4200172		
PATO:0001854	biolink:NamedThing	vertical	A spatial pattern inhering in a bearer by virtue of the bearer's being situated at right angles to the horizon.		hp.json		http://purl.obolibrary.org/obo/PATO_0001854		value_slim
HP:0032511	biolink:PhenotypicFeature	Superiorly positioned umbilicus	The position of the umbilicus (belly button) is abnormally high (superior).		hp.json		http://purl.obolibrary.org/obo/HP_0032511		
PATO:0001851	biolink:NamedThing	swollen	A structure quality inhering in a bearer by virtue of the bearer's exhibiting transient abnormal enlargement, not due to cell proliferation.		hp.json	swelling	http://purl.obolibrary.org/obo/PATO_0001851		value_slim|mpath_slim
GO:0008289	biolink:MolecularActivity	lipid binding	Binding to a lipid.		hp.json		http://purl.obolibrary.org/obo/GO_0008289		goslim_flybase_ribbon|goslim_drosophila|goslim_chembl|goslim_mouse|goslim_candida|goslim_agr|goslim_yeast|goslim_generic|goslim_pir|goslim_plant
PATO:0001852	biolink:NamedThing	dislocated	A positional quality inhering in a bearer by virtue of the bearer's being out of its usual or proper place, or position.		hp.json	dislocation|luxated|relational dislocated quality|luxation	http://purl.obolibrary.org/obo/PATO_0001852		value_slim|mpath_slim
HP:0032510	biolink:PhenotypicFeature	Tendon pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to a tendon.		hp.json		http://purl.obolibrary.org/obo/HP_0032510		
PATO:0001857	biolink:NamedThing	concave	A shape quality in a bearer by virtue of the bearer's curving inward.		hp.json		http://purl.obolibrary.org/obo/PATO_0001857		cell_quality|value_slim
PATO:0001855	biolink:NamedThing	horizontal	A positional quality inhering in a bearer by virtue of the bearer's being in the plane of the horizon.		hp.json		http://purl.obolibrary.org/obo/PATO_0001855		value_slim
GO:0008285	biolink:BiologicalProcess	negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.		hp.json	downregulation of cell proliferation|down regulation of cell proliferation|inhibition of cell proliferation|down-regulation of cell proliferation|negative regulation of cell proliferation	http://purl.obolibrary.org/obo/GO_0008285		
HP:0032517	biolink:PhenotypicFeature	Majocchi's granuloma	Majocchi's granuloma (MG) is an inflammatory and granulomatous, dermatophytic infection characterized by a granulomatous inflammation around the hair follicle. Histopathologically, MG demonstrates a nodular perifollicular granulomatous infiltrate of lymphoid cells, macrophages, epithelioid cells, multinucleated giant cells, and neutrophils. Unlike superficial dermatophytoses, fungal hyphae and spores can be detected not only on the surface of the epidermis but also within or around the hair follicles.		hp.json		http://purl.obolibrary.org/obo/HP_0032517		
GO:0033240	biolink:BiologicalProcess	positive regulation of cellular amine metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amines.		hp.json	positive regulation of amine metabolism	http://purl.obolibrary.org/obo/GO_0033240		
HP:0007549	biolink:PhenotypicFeature	Desquamation of skin soon after birth		UMLS:C1842714	hp.json		http://purl.obolibrary.org/obo/HP_0007549		
HP:0032516	biolink:PhenotypicFeature	Invasive dermatophyte infection	Infection that extends deeply into the dermins by dermatophytes, fungi that typically cause different types of superficial infection (tinea) or skin, hair, or nails.		hp.json		http://purl.obolibrary.org/obo/HP_0032516		
HP:0032519	biolink:PhenotypicFeature	Increased Burr cell count	Burr cells, also known as echinocytes, have a speculated border over the entire cell surface. Burr cells are commonly found in both end-stage renal disease and liver disease. Small numbers of Burr cells are commonly found in healthy individuals.		hp.json		http://purl.obolibrary.org/obo/HP_0032519		
HP:0032518	biolink:PhenotypicFeature	Disseminated dermatophytosis	A type of invasive dermatophyte infection characterized by vascular involvement and dissemination to other organs.		hp.json		http://purl.obolibrary.org/obo/HP_0032518		
HP:0007546	biolink:PhenotypicFeature	Linear hyperpigmentation		UMLS:C3278658	hp.json		http://purl.obolibrary.org/obo/HP_0007546		
HP:0032513	biolink:PhenotypicFeature	Four-vessel umbilical cord	Four-vessel umbilical cord containing two arteries and two veins.		hp.json		http://purl.obolibrary.org/obo/HP_0032513		
HP:0007545	biolink:PhenotypicFeature	Congenital palmoplantar hyperkeratosis	Abnormal thickening of the skin on the palms and soles that is present at birth.	UMLS:C1855633	hp.json	Congenital palmoplantar keratosis|Congenital palmoplantar keratodermia|Congenital palmoplantar keratoderma	http://purl.obolibrary.org/obo/HP_0007545		
PATO:0001850	biolink:NamedThing	scarred	A structural quality inhering in a bearer by virtue of the bearer's being fibrous tissue that replaces normal tissue destroyed by injury or disease.		hp.json		http://purl.obolibrary.org/obo/PATO_0001850		value_slim|mpath_slim
HP:0032515	biolink:PhenotypicFeature	Deep dermatophytosis	A type of invasive dermatophyte infection of the deep dermis characterized by extensive dermal infiltration by fungal elements.		hp.json		http://purl.obolibrary.org/obo/HP_0032515		
HP:0007548	biolink:PhenotypicFeature	obsolete Palmoplantar keratosis with erythema and scale			hp.json		http://purl.obolibrary.org/obo/HP_0007548		
HP:0032514	biolink:PhenotypicFeature	Duplicated lacrimal punctum	A congenital developmental anomaly characterized by the presence of two (instead of the normal one) lacrimal punctum on one or both sides of the face.		hp.json	Lacrimal punctum, duplication|Double lacrimal puncta	http://purl.obolibrary.org/obo/HP_0032514		
HP:0007542	biolink:PhenotypicFeature	Absent pigmentation of the ventral chest	Lack of skin pigmentation (coloring) of the anterior chest.	UMLS:C4024848	hp.json		http://purl.obolibrary.org/obo/HP_0007542		
HP:0007541	biolink:PhenotypicFeature	Frontal cutaneous lipoma	Presence of a cutaneous lipoma on the forehead.	NCIT:C3192|UMLS:C1850970	hp.json		http://purl.obolibrary.org/obo/HP_0007541		
HP:0007544	biolink:PhenotypicFeature	Piebaldism	Piebaldism is characterized by stable and persistent, well-circumscribed depigmented patches present at birth affecting the skin of the face, trunk, and extremities in a symmetrical distribution.	SNOMEDCT_US:6479008|UMLS:C0080024|MSH:D016116|SNOMEDCT_US:718122005	hp.json		http://purl.obolibrary.org/obo/HP_0007544		
HP:0007543	biolink:PhenotypicFeature	Epidermal hyperkeratosis		UMLS:C1848773	hp.json	Increased thickness of skin epidermis	http://purl.obolibrary.org/obo/HP_0007543		
GO:0033239	biolink:BiologicalProcess	negative regulation of cellular amine metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines.		hp.json	negative regulation of amine metabolism	http://purl.obolibrary.org/obo/GO_0033239		
GO:0033238	biolink:BiologicalProcess	regulation of cellular amine metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform amines.		hp.json	regulation of amine metabolism	http://purl.obolibrary.org/obo/GO_0033238		
HP:0032520	biolink:PhenotypicFeature	Masseter muscular weakness	Reduced strength of the masseter muscle, whose primary function is to elevate the mandible and thereby raise the mandible towards the maxilla, closing the jaw.		hp.json		http://purl.obolibrary.org/obo/HP_0032520		
PATO:0001865	biolink:NamedThing	spheroid	A convex 3-D shape quality inhering in a bearer by virtue of the bearer's having a quadric surface in three dimensions obtained by rotating an ellipse about one of its principal axes. Includes spheres and oblate/prolate spheroids.		hp.json	sphericality	http://purl.obolibrary.org/obo/PATO_0001865		value_slim|mpath_slim|cell_quality
HP:0032522	biolink:PhenotypicFeature	Ameliorated by immunosuppresion	Applies to a sign or symptom that is improved or made more bearable by treatment with immunosuppresive medication.		hp.json	Immunosupressive therapy improves condition	http://purl.obolibrary.org/obo/HP_0032522		
PATO:0001863	biolink:NamedThing	chronic	A duration quality of a process inhering in a bearer by virtue of the bearer's having slow progressive course of indefinite duration.		hp.json		http://purl.obolibrary.org/obo/PATO_0001863		hpo_slim|value_slim|mpath_slim
HP:0032521	biolink:PhenotypicFeature	Self hugging	Involuntary, tic-like movements consisted of crossing both arms across the chest and tensing the body or clasping the hands and squeezing the arms to the sides. The movements last a few seconds and may occur in series or flurries, generally accompanied by facial grimacing and occasional grunting.		hp.json	Spasmodic upper-body squeeze	http://purl.obolibrary.org/obo/HP_0032521		
PATO:0001869	biolink:NamedThing	pathological	A quality inhering in a bearer by virtue of the bearer's being abnormal and having a destructive effect on living tissue.		hp.json		http://purl.obolibrary.org/obo/PATO_0001869		abnormal_slim|value_slim
HP:0032528	biolink:PhenotypicFeature	Elevated urinary 4-hydroxybutyric acid	An increased amount of 4-hydroxybutyric acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032528		
HP:0032527	biolink:PhenotypicFeature	Inferiorly positioned umbilicus	The position of the umbilicus (belly button) is abnormally low (inferior).		hp.json	Low-set umbilicus|Low set umbilicus	http://purl.obolibrary.org/obo/HP_0032527		
HP:0032529	biolink:PhenotypicFeature	obsolete Elevated circulating gamma-aminobutyric acid concentration			hp.json		http://purl.obolibrary.org/obo/HP_0032529		
HP:0032524	biolink:PhenotypicFeature	Long thumb	Length of the thumb is greater than normal.		hp.json		http://purl.obolibrary.org/obo/HP_0032524		
HP:0007556	biolink:PhenotypicFeature	Plantar hyperkeratosis	Hyperkeratosis affecting the sole of the foot.	UMLS:C1856954	hp.json	Plantar hyperkeratoses	http://purl.obolibrary.org/obo/HP_0007556		
HP:0032523	biolink:PhenotypicFeature	Tendon thickening	An abnormal increase in the thickness (diameter) of a tendon.		hp.json		http://purl.obolibrary.org/obo/HP_0032523		
HP:0007559	biolink:PhenotypicFeature	Localized epidermolytic hyperkeratosis		MSH:D053546|UMLS:C1721006	hp.json	Localised epidermolytic hyperkeratosis	http://purl.obolibrary.org/obo/HP_0007559		
HP:0032526	biolink:PhenotypicFeature	Ameliorated by acetylcholinesterase inhibitor	Applies to a sign or symptom that is improved or made more bearable by an acetylcholinesterase inhibitor such as mestinon or tensilon.		hp.json		http://purl.obolibrary.org/obo/HP_0032526		
GO:0035898	biolink:NamedThing	parathyroid hormone secretion			hp.json		http://purl.obolibrary.org/obo/GO_0035898		
HP:0032525	biolink:PhenotypicFeature	Aggravated by acetylcholinesterase inhibitor	Applied to a sign or symptom that is worsened by treatment with an acetylcholinesterase inhibitor such as tensilon (edrophonium) or pyridostigmine (Mestinon).		hp.json		http://purl.obolibrary.org/obo/HP_0032525		
HP:0007553	biolink:PhenotypicFeature	Congenital symmetrical palmoplantar keratosis		UMLS:C1855459	hp.json		http://purl.obolibrary.org/obo/HP_0007553		
HP:0007552	biolink:PhenotypicFeature	Abnormal subcutaneous fat tissue distribution		UMLS:C1859347	hp.json	Abnormal fat tissue distribution below the skin	http://purl.obolibrary.org/obo/HP_0007552		
HP:0007554	biolink:PhenotypicFeature	Confetti hypopigmentation pattern of lower leg skin		UMLS:C4024847	hp.json	Confetti hypopigmentation pattern of lower leg skin	http://purl.obolibrary.org/obo/HP_0007554		
HP:0007550	biolink:PhenotypicFeature	Hypohidrosis or hyperhidrosis		UMLS:C4021831	hp.json	Lack of sweating or excessive sweating	http://purl.obolibrary.org/obo/HP_0007550		
HP:0032531	biolink:PhenotypicFeature	Elevated CSF gamma-aminobutyric acid concentration			hp.json		http://purl.obolibrary.org/obo/HP_0032531		
PATO:0001875	biolink:NamedThing	triangular	A shape quality inhering in a bearer by virtue of the bearer's having three angles.		hp.json	delta shaped|triangle|triangle-shaped|deltoid	http://purl.obolibrary.org/obo/PATO_0001875		value_slim|cell_quality
HP:0032530	biolink:PhenotypicFeature	Decreased succinic semialdehyde dehydrogenase level	Reduced level of succinic semialdehyde dehydrogenase (SSADH).		hp.json		http://purl.obolibrary.org/obo/HP_0032530		
PATO:0001876	biolink:NamedThing	dumbbell-shaped	A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having two parts, roughly spherical and of equal size, connected by a bar.		hp.json		http://purl.obolibrary.org/obo/PATO_0001876		value_slim|cell_quality
PATO:0001873	biolink:NamedThing	cylindrical	A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section.		hp.json	tubulate|rod-like|rod-shaped	http://purl.obolibrary.org/obo/PATO_0001873		value_slim|cell_quality
HP:0032533	biolink:PhenotypicFeature	Elevated circulating acetone concentration	An increased level of acetone in the blood circulation. Acetone is one of the predominant ketone bodies.		hp.json		http://purl.obolibrary.org/obo/HP_0032533		
HP:0032532	biolink:PhenotypicFeature	Elevated CSF 4-hydroxybutyric acid concentration	Abnormally increased level of 4-hydroxybutyric acid in the cerebrospinal fluid (CSF).		hp.json	Elevated CSF GHB levels|Elevated CSF gamma-hydroxybutyric acid	http://purl.obolibrary.org/obo/HP_0032532		
PATO:0001874	biolink:NamedThing	discoid	A shape quality inhering in a bearer by virtue of the bearer's being cylindrical, in which the height is less than the diameter.		hp.json	disc-shaped|disk-shaped	http://purl.obolibrary.org/obo/PATO_0001874		value_slim|cell_quality
PATO:0001879	biolink:NamedThing	U-shaped	A concave 3-D shape quality inhering in a bearer by virtue of the bearer's being shaped in the form of the letter U.		hp.json	horseshoe|horseshoe shaped	http://purl.obolibrary.org/obo/PATO_0001879		value_slim|cell_quality
PATO:0001878	biolink:NamedThing	sigmoid	A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped.		hp.json	S-shaped|sigmoidal	http://purl.obolibrary.org/obo/PATO_0001878		value_slim|cell_quality
HP:0032539	biolink:PhenotypicFeature	Joint extensor surface localization	Applies to an abnormality that is situated in extensor surface of the joint. The extensor surface refers to the skin on the opposite side of a joint.		hp.json		http://purl.obolibrary.org/obo/HP_0032539		
HP:0032538	biolink:PhenotypicFeature	Pretibial dimple	A groove or crease on the shins (pretibial, i.e., over the shin bone). Pretibial creases may be obvious at birth and may range from 3 cm to over 15 cm in length and lenghten as the limb grows. They appear as an elongated dimple because of the attachment of skin to underlying tissue (e.g., to the tibia). The dimple or crease grows in proportion to the growth of the leg.		hp.json		http://purl.obolibrary.org/obo/HP_0032538		
GO:0008272	biolink:BiologicalProcess	sulfate transport	The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	sulphate transport	http://purl.obolibrary.org/obo/GO_0008272		
GO:0035883	biolink:BiologicalProcess	enteroendocrine cell differentiation	The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.		hp.json		http://purl.obolibrary.org/obo/GO_0035883		
HP:0007529	biolink:PhenotypicFeature	Hidrotic ectodermal dysplasia		MSH:D004476|UMLS:C0162361|SNOMEDCT_US:54209007	hp.json		http://purl.obolibrary.org/obo/HP_0007529		
HP:0007524	biolink:PhenotypicFeature	Atypical neurofibromatosis		UMLS:C0220695|MSH:C537392	hp.json		http://purl.obolibrary.org/obo/HP_0007524		
HP:0032535	biolink:PhenotypicFeature	Cervical (neck)	Applies to an abnormality that is situated in the neck.		hp.json		http://purl.obolibrary.org/obo/HP_0032535		
PATO:0001872	biolink:NamedThing	cuboid	A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resemblance to a cube (a 3-D shape with a square cross section).		hp.json	cuboidal|block-like	http://purl.obolibrary.org/obo/PATO_0001872		value_slim|cell_quality
GO:0035886	biolink:BiologicalProcess	vascular associated smooth muscle cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.		hp.json	vascular smooth muscle cell differentiation|VSMC differentiation	http://purl.obolibrary.org/obo/GO_0035886		
HP:0032534	biolink:PhenotypicFeature	Exacerbated by methylxanthine ingestion	Applied to a sign or symptom that is worsened by ingestion of food containing a methylxanthine compound (for instance, coffee, caffeine, chocolate).		hp.json	Methylxanthines produce worsening	http://purl.obolibrary.org/obo/HP_0032534		
GO:0035887	biolink:BiologicalProcess	aortic smooth muscle cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta.		hp.json		http://purl.obolibrary.org/obo/GO_0035887		
HP:0007526	biolink:PhenotypicFeature	Hypopigmented skin patches on arms		UMLS:C4024852	hp.json	Patchy loss of skin colour on arms|Hypopigmented upper extremeity skin patches|Patchy loss of skin color on arms	http://purl.obolibrary.org/obo/HP_0007526		
HP:0032537	biolink:PhenotypicFeature	Delayed fracture healing	A delay in healing of a fracture past the expected duration.		hp.json		http://purl.obolibrary.org/obo/HP_0032537		
HP:0007525	biolink:PhenotypicFeature	Yellow subcutaneous tissue covered by thin, scaly skin		UMLS:C1850533	hp.json		http://purl.obolibrary.org/obo/HP_0007525		
HP:0032536	biolink:PhenotypicFeature	Increased number of lymph nodes	An abnormally elevated number of lymph nodes in an anatomical region.		hp.json		http://purl.obolibrary.org/obo/HP_0032536		
HP:0007522	biolink:PhenotypicFeature	Increased number of skin folds		UMLS:C4024853	hp.json	Increased number of skin folds	http://purl.obolibrary.org/obo/HP_0007522		
HP:0007521	biolink:PhenotypicFeature	Irregular hyperpigmentation of back		UMLS:C4024854	hp.json		http://purl.obolibrary.org/obo/HP_0007521		
OBO:MAXO_0000075	biolink:NamedThing	digestive system testing	The quantitative measurement of digestive system tests to diagnose or treat a digestive disorder using clinical laboratory procedures, imaging tests, endoscopic or other procedures.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000075		
OBO:MAXO_0000074	biolink:NamedThing	pancreatic function testing	A procedure to measure pancreatic secretion to discriminate between pancreatic and nonpancreatic causes of malabsorption.	NCIT:C97101	hp.json	pancreatic function assessment	http://purl.obolibrary.org/obo/MAXO_0000074		
GO:0033218	biolink:MolecularActivity	amide binding	Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.		hp.json		http://purl.obolibrary.org/obo/GO_0033218		goslim_pir
GO:0035878	biolink:BiologicalProcess	nail development	The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it.		hp.json		http://purl.obolibrary.org/obo/GO_0035878		
HP:0032542	biolink:PhenotypicFeature	Exacerbated by pregnancy	Applied to a sign or symptom that is worsened by being pregnant.		hp.json		http://purl.obolibrary.org/obo/HP_0032542		
HP:0032541	biolink:PhenotypicFeature	Knuckle pad	Knuckle pads are benign fibrofatty subcutaneous pads located over the proximal interphalangeal (PIP) joints that can be mistaken for arthritis. Rarely they affect the dorsal aspect of the metacarpophalangeal (MCP) joints. Clinically they are painless and often affect both hands in an asymmetrical pattern.		hp.json	Knuckle pads on dorsal aspect of finger joints	http://purl.obolibrary.org/obo/HP_0032541		
HP:0032544	biolink:PhenotypicFeature	Predominant small joint localization	Applies to an abnormality that mainly affects the small joints, including fingers, toes, interphalangeal, metacarpophalangeal, metatarsophalangeal, wrists, ankles, vertebrae, and neck.		hp.json		http://purl.obolibrary.org/obo/HP_0032544		
HP:0032543	biolink:PhenotypicFeature	Lithoptysis	Expectoration (coughing up) of a broncholith. Broncholithiasis is defined as the presence of calculi in the tracheobronchial tree. It is a rare disease but can be characterized by clinical and radiological findings of a calcified lymph node eroding bronchial wall and opening into the bronchial lumen.		hp.json		http://purl.obolibrary.org/obo/HP_0032543		
GO:0008277	biolink:BiologicalProcess	regulation of G protein-coupled receptor signaling pathway	Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.		hp.json	regulation of G-protein coupled receptor protein signalling pathway|regulation of G-protein coupled receptor protein signaling pathway|regulation of G protein coupled receptor protein signalling pathway|regulation of GPCR protein signaling pathway|regulation of G-protein-coupled receptor protein signalling pathway|regulation of GPCR protein signalling pathway|regulation of G protein coupled receptor protein signaling pathway	http://purl.obolibrary.org/obo/GO_0008277		
OBO:MAXO_0000072	biolink:NamedThing	ultrasonography procedure	The use of ultrasound to produce images of structures in the human body.	NCIT:C17230|ERO:0001325	hp.json	diagnostic ultrasound|sonography|medical sonography|ultrasound procedure	http://purl.obolibrary.org/obo/MAXO_0000072		
HP:0032540	biolink:PhenotypicFeature	Joint flexor surface localization	Applies to an abnormality that is situated in flexor surface of the joint. The flexor surface refers to the skin that touches when a joint is bent (flexed).		hp.json		http://purl.obolibrary.org/obo/HP_0032540		
GO:0008284	biolink:BiologicalProcess	positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.		hp.json	activation of cell proliferation|up-regulation of cell proliferation|positive regulation of cell proliferation|upregulation of cell proliferation|stimulation of cell proliferation|up regulation of cell proliferation	http://purl.obolibrary.org/obo/GO_0008284		
NCBITaxon:1206794	biolink:OrganismalEntity	Ecdysozoa		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_1206794		
GO:0008283	biolink:BiologicalProcess	cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.		hp.json	cell proliferation	http://purl.obolibrary.org/obo/GO_0008283		goslim_chembl|goslim_mouse|goslim_agr|goslim_pir|goslim_flybase_ribbon|goslim_drosophila
HP:0032549	biolink:PhenotypicFeature	Persistent asymmetrical tonic neck reflex	Persistence beyond the normal age (roughly the first half of the first year of life) of the asymmetric tonic neck reflex (ATNR), which is an easily elicited primitive reflex in the immediate newborn period. The ATNR refers to the phenomenon whereby when the face of an infant is turned to one side, the ipsilateral arm and leg extend and the contralateral arm and leg flex. This posture has been compared to a typical posture of fencers.		hp.json	Tonic neck reflex asymmetrical and persistent|Persistent fencer's reflex	http://purl.obolibrary.org/obo/HP_0032549		
HP:0032546	biolink:PhenotypicFeature	Abdominal guarding	A voluntary contraction of the abdominal wall musculature to avoid pain.		hp.json		http://purl.obolibrary.org/obo/HP_0032546		
HP:0007535	biolink:PhenotypicFeature	Hypopigmented streaks		UMLS:C1866244	hp.json		http://purl.obolibrary.org/obo/HP_0007535		
PATO:0001883	biolink:NamedThing	clavate	A concave 3-D shape quality inhering in a bearer by virtue of the bearer's gradually becoming thicker towards the end.		hp.json	club-like|clubbed|club-shaped	http://purl.obolibrary.org/obo/PATO_0001883		value_slim
HP:0032545	biolink:PhenotypicFeature	Abdominal rigidity	Involuntary tightening of the abdominal musculature that occurs in response to touching the abdomen to avoid pain. Rigidity can occur in the presence of abdominal inflammation and usually involves only the inflamed area.		hp.json	Rigid abdomen	http://purl.obolibrary.org/obo/HP_0032545		
HP:0007534	biolink:PhenotypicFeature	Congenital posterior occipital alopecia	Loss of hair in the occipital region of the scalp with congenital onset.	UMLS:C4024850	hp.json		http://purl.obolibrary.org/obo/HP_0007534		
HP:0032548	biolink:PhenotypicFeature	Increased placental thickness	Abnormally elevated placental thickness.		hp.json	Placental thickness increased	http://purl.obolibrary.org/obo/HP_0032548		
HP:0007537	biolink:PhenotypicFeature	Severe photosensitivity	A severe degree of photosensitivity of the skin.	UMLS:C1849186	hp.json	Severe sun sensitivity	http://purl.obolibrary.org/obo/HP_0007537		
HP:0032547	biolink:PhenotypicFeature	Low intraocular pressure	An abnormal decrease of the pressure within the eye.		hp.json	Ocular hypotony	http://purl.obolibrary.org/obo/HP_0032547		
HP:0007536	biolink:PhenotypicFeature	Aplasia cutis congenita of midline scalp vertex		UMLS:C4024849	hp.json		http://purl.obolibrary.org/obo/HP_0007536		
HP:0007530	biolink:PhenotypicFeature	Punctate palmoplantar hyperkeratosis		UMLS:C4024851	hp.json		http://purl.obolibrary.org/obo/HP_0007530		
GO:0033212	biolink:BiologicalProcess	iron import into cell	The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.		hp.json	ferrous ion import|iron assimilation|ferrous iron import|ferrous iron uptake	http://purl.obolibrary.org/obo/GO_0033212		
PATO:0001818	biolink:NamedThing	progressive	A quality of a single process inhering in a bearer by virtue of the bearer's increasing over time.		hp.json		http://purl.obolibrary.org/obo/PATO_0001818		value_slim|mpath_slim|hpo_slim
PATO:0001815	biolink:NamedThing	fatigability	A strength quality inhering in a bearer by virtue of the bearer's disposition to lose strength.		hp.json		http://purl.obolibrary.org/obo/PATO_0001815		scalar_slim|disposition_slim|attribute_slim
PATO:0001816	biolink:NamedThing	increased fatigability	A fatigability which is relatively high.		hp.json	high fatigability	http://purl.obolibrary.org/obo/PATO_0001816		disposition_slim|value_slim
HP:0007590	biolink:PhenotypicFeature	Aplasia cutis congenita over posterior parietal area		UMLS:C1863495	hp.json		http://purl.obolibrary.org/obo/HP_0007590		
PATO:0001819	biolink:NamedThing	atretic	A morphological quality inhering in a bearer by virtue of the bearer's absence or closure of a normal body orifice or tubular passage.		hp.json	atresia	http://purl.obolibrary.org/obo/PATO_0001819		value_slim|mpath_slim
PATO:0001810	biolink:NamedThing	wrinkled	A grooved texture quality inhering in a bearer by virtue of the bearer's being marked by one or more creases in a normally smooth surface.		hp.json		http://purl.obolibrary.org/obo/PATO_0001810		value_slim|mpath_slim
GO:0035869	biolink:CellularComponent	ciliary transition zone	A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.		hp.json	cilial transition zone|cilium transition zone|connecting cilium	http://purl.obolibrary.org/obo/GO_0035869		
HP:0007589	biolink:PhenotypicFeature	Aplasia cutis congenita on trunk or limbs	A developmental defect resulting in the congenital absence of skin on the trunk or the limbs.	UMLS:C1863496	hp.json		http://purl.obolibrary.org/obo/HP_0007589		
HP:0007586	biolink:PhenotypicFeature	Telangiectases producing 'marbled' skin		UMLS:C4024839	hp.json		http://purl.obolibrary.org/obo/HP_0007586		
HP:0007585	biolink:PhenotypicFeature	Skin fragility with non-scarring blistering		UMLS:C1851562	hp.json		http://purl.obolibrary.org/obo/HP_0007585		
HP:0007588	biolink:PhenotypicFeature	Reticular hyperpigmentation	Increased pigmentation of the skin with a netlike (reticular) pattern.	UMLS:C1851972	hp.json	Reticulate hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007588		
HP:0007587	biolink:PhenotypicFeature	Numerous pigmented freckles		UMLS:C1968565	hp.json	Numerous pigmented freckles	http://purl.obolibrary.org/obo/HP_0007587		
HP:0007581	biolink:PhenotypicFeature	Mediosternal, longitudinal streak of hypopigmentation		UMLS:C4024840	hp.json		http://purl.obolibrary.org/obo/HP_0007581		
HP:0007583	biolink:PhenotypicFeature	Telangiectasia macularis eruptiva perstans		UMLS:C0263402|SNOMEDCT_US:8214000	hp.json		http://purl.obolibrary.org/obo/HP_0007583		
PATO:0001828	biolink:NamedThing	male pseudohermaphrodite	A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of male and external sexual characteristics of female.		hp.json		http://purl.obolibrary.org/obo/PATO_0001828		value_slim
PATO:0001829	biolink:NamedThing	female pseudohermaphrodite	A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of female and external sexual characteristics of male.		hp.json		http://purl.obolibrary.org/obo/PATO_0001829		value_slim
PATO:0001827	biolink:NamedThing	pseudohermaphrodite	A biological sex quality inhering in an individual or a population by virtue of having internal reproductive organs of one sex and external sexual characteristics of the other sex.		hp.json		http://purl.obolibrary.org/obo/PATO_0001827		value_slim
PATO:0001821	biolink:NamedThing	imperforate	A structural quality inhering in a bearer by virtue of the bearer's having no opening.		hp.json	unperforated	http://purl.obolibrary.org/obo/PATO_0001821		mpath_slim|value_slim
PATO:0001824	biolink:NamedThing	dry	A wetness quality inhering in a bearer by virtue of the bearer's not being covered by a liquid.		hp.json		http://purl.obolibrary.org/obo/PATO_0001824		value_slim|mpath_slim
PATO:0001822	biolink:NamedThing	wetness	A quality inhering in a bearer by virtue of whether the bearer's being covered by a liquid.		hp.json		http://purl.obolibrary.org/obo/PATO_0001822		attribute_slim|mpath_slim|scalar_slim
GO:0035855	biolink:BiologicalProcess	megakaryocyte development	The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.		hp.json	megakaryocyte cell development	http://purl.obolibrary.org/obo/GO_0035855		
CHEBI:61409	biolink:ChemicalSubstance	dihydroxyphenylacetic acid	A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.		hp.json	dihydroxyphenylacetic acids	http://purl.obolibrary.org/obo/CHEBI_61409		3_STAR
HP:0007597	biolink:PhenotypicFeature	obsolete Congenital palmoplantar keratodermia			hp.json		http://purl.obolibrary.org/obo/HP_0007597		
OBO:MAXO_0000018	biolink:NamedThing	biomarker analysis	A broad subcategory of medical signs or objective indications of medical state which can be measured accurately and reproducibly.	NCIT:C63333	hp.json		http://purl.obolibrary.org/obo/MAXO_0000018		
HP:0007596	biolink:PhenotypicFeature	Painful subcutaneous lipomas	The presence of multiple subcutaneous lipoma that cause pain.	UMLS:C4024838	hp.json	Painful noncancerous fat tissue tumor under the skin|Painful noncancerous fat tissue tumour under the skin	http://purl.obolibrary.org/obo/HP_0007596		
HP:0007599	biolink:PhenotypicFeature	Generalized reticulate brown pigmentation		UMLS:C4024836	hp.json	Generalised reticulate brown pigmentation	http://purl.obolibrary.org/obo/HP_0007599		
HP:0007598	biolink:PhenotypicFeature	Bilateral single transverse palmar creases	The distal and proximal transverse palmar creases are merged into a single transverse palmar crease on both hands.	UMLS:C1862095	hp.json		http://purl.obolibrary.org/obo/HP_0007598		
HP:0007592	biolink:PhenotypicFeature	Aplasia/Hypoplastia of the eccrine sweat glands	Absence or developmental hypoplasia of the eccrine sweat glands.	UMLS:C1844618	hp.json	Hypoplastic-absent eccrine sweat glands	http://purl.obolibrary.org/obo/HP_0007592		
HP:0007595	biolink:PhenotypicFeature	Redundant skin in infancy		UMLS:C1835587	hp.json	Excess skin in infancy	http://purl.obolibrary.org/obo/HP_0007595		
GO:0008227	biolink:MolecularActivity	G protein-coupled amine receptor activity	Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.		hp.json	biogenic amine receptor|G-protein coupled amine receptor activity|amine receptor activity, G-protein coupled	http://purl.obolibrary.org/obo/GO_0008227		
GO:0035846	biolink:BiologicalProcess	oviduct epithelium development	The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct.		hp.json	fallopian tube epithelium development	http://purl.obolibrary.org/obo/GO_0035846		
GO:0035847	biolink:BiologicalProcess	uterine epithelium development	The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.		hp.json	uterus epithelial development	http://purl.obolibrary.org/obo/GO_0035847		
GO:0035848	biolink:BiologicalProcess	oviduct morphogenesis	The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism.		hp.json	fallopian tube morphogenesis	http://purl.obolibrary.org/obo/GO_0035848		
HP:0007569	biolink:PhenotypicFeature	Generalized seborrheic dermatitis	Seborrheic dermatitis that is not localized to any one particular region.	UMLS:C4024844	hp.json	Generalized seborrheic eczema|Generalised seborrheic dermatitis|Generalised seborrheic eczema	http://purl.obolibrary.org/obo/HP_0007569		
GO:0035844	biolink:BiologicalProcess	cloaca development	The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates.		hp.json	cloacal development	http://purl.obolibrary.org/obo/GO_0035844		
HP:0007566	biolink:PhenotypicFeature	Index finger dermatoglyphic radial loop		UMLS:C4024845	hp.json		http://purl.obolibrary.org/obo/HP_0007566		
HP:0007565	biolink:PhenotypicFeature	Multiple cafe-au-lait spots	The presence of six or more cafe-au-lait spots.	UMLS:C1861975|MSH:C537421	hp.json	Multiple birthmarks|Multiple flat light-brown marks on skin	http://purl.obolibrary.org/obo/HP_0007565		
HP:0007560	biolink:PhenotypicFeature	Unusual dermatoglyphics		UMLS:C4024846	hp.json		http://purl.obolibrary.org/obo/HP_0007560		
HP:0007561	biolink:PhenotypicFeature	obsolete Telangiectases in sun-exposed and nonexposed skin			hp.json		http://purl.obolibrary.org/obo/HP_0007561		
PATO:0001848	biolink:NamedThing	asymmetrically curved	A curvature quality inhering in a bearer by virtue of the bearer's being curved asymmetrically.		hp.json		http://purl.obolibrary.org/obo/PATO_0001848		cell_quality|value_slim
GO:0035834	biolink:BiologicalProcess	indole alkaloid metabolic process	The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton.		hp.json	indole alkaloid metabolism	http://purl.obolibrary.org/obo/GO_0035834		
GO:0035835	biolink:BiologicalProcess	indole alkaloid biosynthetic process	The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton.		hp.json	indole alkaloid synthesis|indole alkaloid formation|indole alkaloid biosynthesis|indole alkaloid anabolism	http://purl.obolibrary.org/obo/GO_0035835		
HP:0032500	biolink:PhenotypicFeature	Exacerbated by tobacco use	Applied to a sign or symptom that is worsened by smoking tobacco products.		hp.json	Exacerbated by smoking|Aggravated by tobacco use|Smoking or tobacco use exacerbates symptoms	http://purl.obolibrary.org/obo/HP_0032500		
PATO:0001847	biolink:NamedThing	constricted	A structural quality inhering in a bearer by virtue of the bearer's being drawn together, compressed or squeezed physically.		hp.json	stricture|stenotic|stenosis	http://purl.obolibrary.org/obo/PATO_0001847		value_slim
PATO:0001845	biolink:NamedThing	irregular rhythm	A rhythm quality inhering in a bearer by virtue of the bearer's lacking rhythm lacking pattern.		hp.json		http://purl.obolibrary.org/obo/PATO_0001845		value_slim
HP:0032506	biolink:PhenotypicFeature	Alien limb phenomenon	Alien limb phenomenon refers to involuntary motor activity of a limb in conjunction with the feeling of estrangement from that limb.		hp.json		http://purl.obolibrary.org/obo/HP_0032506		
HP:0032505	biolink:PhenotypicFeature	Hydrophobia	Pharyngeal spasms provoked by an attempt to drink.		hp.json		http://purl.obolibrary.org/obo/HP_0032505		
CHEBI:36498	biolink:ChemicalSubstance	galactosylceramide			hp.json		http://purl.obolibrary.org/obo/CHEBI_36498		
HP:0032508	biolink:PhenotypicFeature	Polyembolokoilamania	Habitual insertion of foreign bodies into bodily orifices.		hp.json		http://purl.obolibrary.org/obo/HP_0032508		
HP:0032507	biolink:PhenotypicFeature	Labiomental fasciculations	Fasciculations affecting the tongue muscle and the musculature of the chin.		hp.json	Fasciculations, labiomental	http://purl.obolibrary.org/obo/HP_0032507		
HP:0032502	biolink:PhenotypicFeature	Exacerbated by barbiturate medication	Applied to a sign or symptom that is worsened by taking barbituates.		hp.json	Barbiturates produce worsening	http://purl.obolibrary.org/obo/HP_0032502		
HP:0032501	biolink:PhenotypicFeature	Exacerbated by contraceptive medication	Applied to a sign or symptom that is worsened by taking contraceptive medication.		hp.json	Contraceptive pills aggravate symptoms	http://purl.obolibrary.org/obo/HP_0032501		
HP:0032504	biolink:PhenotypicFeature	Lhermitte's sign	An electric shock-like sensation that occurs on flexion of the neck. This sensation radiates down the spine, often into the legs, arms, and sometimes to the trunk.		hp.json	Lhermitte's phenomenon|Barber chair phenomenon	http://purl.obolibrary.org/obo/HP_0032504		
HP:0032503	biolink:PhenotypicFeature	Ameliorated by ethanol ingestion	Applies to a sign or symptom that is improved or made more bearable by drinking alcohol (ethanol).		hp.json	Ethanol reduces manifestations	http://purl.obolibrary.org/obo/HP_0032503		
HP:0007574	biolink:PhenotypicFeature	Generalized bronze hyperpigmentation		UMLS:C4024842|UMLS:C2939074	hp.json	Bronze skin|Generalised bronze hyperpigmentation	http://purl.obolibrary.org/obo/HP_0007574		
HP:0007576	biolink:PhenotypicFeature	Palmar neurofibromas		UMLS:C4024841	hp.json		http://purl.obolibrary.org/obo/HP_0007576		
HP:0007570	biolink:PhenotypicFeature	Hyperkeratosis lenticularis perstans	Hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease, is a keratinization abnormality characterized by small, asymptomatic erythematous papules that leave characteristic punctate bleeding when they become detached. The lesions generally occur symmetrically along the top of the foot and on the legs, appearing more rarely on the arms, forearms, palms, and soles, and even on the oral mucosa.	SNOMEDCT_US:28488007|UMLS:C0263420|MSH:C538377	hp.json	Flegel disease	http://purl.obolibrary.org/obo/HP_0007570		
HP:0032509	biolink:PhenotypicFeature	Onychotillomania	Onychotillomania is characterized by the compulsive or irresistible urge in patients to pick at, pull off, or harmfully bite or chew their nails.		hp.json		http://purl.obolibrary.org/obo/HP_0032509		
HP:0007573	biolink:PhenotypicFeature	Late onset atopic dermatitis	A form of atopic dermatitis with onset in adulthood characterized by atopic red face, chronic lichenified eczema on the trunk, subacute or psoriasiform dermatitis.	UMLS:C4024843|UMLS:C4280439	hp.json	Late onset baby eczema	http://purl.obolibrary.org/obo/HP_0007573		
HP:0007572	biolink:PhenotypicFeature	Hyperpigmented streaks		UMLS:C1866245	hp.json		http://purl.obolibrary.org/obo/HP_0007572		
GO:0045196	biolink:BiologicalProcess	establishment or maintenance of neuroblast polarity	Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.		hp.json	establishment and/or maintenance of neuroblast cell polarity	http://purl.obolibrary.org/obo/GO_0045196		
GO:1901692	biolink:BiologicalProcess	regulation of compound eye retinal cell apoptotic process	Any process that modulates the frequency, rate or extent of compound eye retinal cell apoptotic process.		hp.json		http://purl.obolibrary.org/obo/GO_1901692		
GO:1901699	biolink:BiologicalProcess	cellular response to nitrogen compound	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.		hp.json	cellular response to nitrogen molecular entity	http://purl.obolibrary.org/obo/GO_1901699		
GO:1901698	biolink:BiologicalProcess	response to nitrogen compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus.		hp.json	response to nitrogen molecular entity	http://purl.obolibrary.org/obo/GO_1901698		
GO:1901693	biolink:BiologicalProcess	negative regulation of compound eye retinal cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of compound eye retinal cell apoptotic process.		hp.json	down-regulation of compound eye retinal cell apoptotic process|down regulation of compound eye retinal cell apoptotic process|inhibition of compound eye retinal cell apoptotic process|downregulation of compound eye retinal cell apoptotic process	http://purl.obolibrary.org/obo/GO_1901693		
GO:1901694	biolink:BiologicalProcess	positive regulation of compound eye retinal cell apoptotic process	Any process that activates or increases the frequency, rate or extent of compound eye retinal cell apoptotic process.		hp.json	upregulation of compound eye retinal cell apoptotic process|induction of compound eye retinal cell programmed cell death|up-regulation of compound eye retinal cell apoptotic process|up regulation of compound eye retinal cell apoptotic process|activation of compound eye retinal cell apoptotic process	http://purl.obolibrary.org/obo/GO_1901694		
GO:0070174	biolink:BiologicalProcess	negative regulation of enamel mineralization	Any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.		hp.json		http://purl.obolibrary.org/obo/GO_0070174		
GO:0070175	biolink:BiologicalProcess	positive regulation of enamel mineralization	Any process that activates or increases the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.		hp.json		http://purl.obolibrary.org/obo/GO_0070175		
GO:0070172	biolink:BiologicalProcess	positive regulation of tooth mineralization	Any process that activates or increases the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.		hp.json		http://purl.obolibrary.org/obo/GO_0070172		
GO:0070173	biolink:BiologicalProcess	regulation of enamel mineralization	Any process that modulates the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel.		hp.json		http://purl.obolibrary.org/obo/GO_0070173		
GO:0070170	biolink:BiologicalProcess	regulation of tooth mineralization	Any process that modulates the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.		hp.json		http://purl.obolibrary.org/obo/GO_0070170		
GO:0070171	biolink:BiologicalProcess	negative regulation of tooth mineralization	Any process that stops, prevents, or reduces the frequency, rate or extent of tooth mineralization, the deposition of calcium salts in tooth structures.		hp.json		http://purl.obolibrary.org/obo/GO_0070171		
OBO:MAXO_0000124	biolink:NamedThing	disease screening	The use of any device, marker, or other means for the purpose of detecting the presence of disease, usually in asymptomatic individuals.	NCIT:C15419	hp.json		http://purl.obolibrary.org/obo/MAXO_0000124		
OBO:MAXO_0000127	biolink:NamedThing	genetic testing	The process of isolating and testing the DNA of an embryo or a person to detect the presence of genetic alterations or defects that may predispose to the future development of a disease or disorder.	NCIT:C15709	hp.json	genetic analysis	http://purl.obolibrary.org/obo/MAXO_0000127		
OBO:MAXO_0000125	biolink:NamedThing	audiometric testing	Testing conducted utilizing a manual or microprocessor audiometer to test for hearing loss.	NCIT:C38036	hp.json	hearing testing procedure|audiometry test|hearing exam procedure	http://purl.obolibrary.org/obo/MAXO_0000125		
OBO:MAXO_0000126	biolink:NamedThing	cancer screening	The use of any device, marker, or other means for the purpose of detecting the presence Neoplasm, usually in asymptomatic individuals.	NCIT:C15406	hp.json	Neoplasm screening	http://purl.obolibrary.org/obo/MAXO_0000126		
GO:0070161	biolink:CellularComponent	anchoring junction	A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.		hp.json	anchoring cell junction	http://purl.obolibrary.org/obo/GO_0070161		
PATO:0001802	biolink:NamedThing	loose	A pattern quality inhering in a bearer by virtue of the bearer's not being compact or dense in arrangement.		hp.json		http://purl.obolibrary.org/obo/PATO_0001802		value_slim
PATO:0001800	biolink:NamedThing	water composition	A composition quality inhering in an bearer by virtue of the quantities or relative ratios of water of the inhering entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0001800		scalar_slim|attribute_slim
PATO:0001801	biolink:NamedThing	decreased water composition	A composition quality inhering in an bearer by virtue of the reduction in amount of water the bearer contains.		hp.json	dry|dehydrated	http://purl.obolibrary.org/obo/PATO_0001801		value_slim
GO:0070169	biolink:BiologicalProcess	positive regulation of biomineral tissue development	Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.		hp.json		http://purl.obolibrary.org/obo/GO_0070169		
GO:0070167	biolink:BiologicalProcess	regulation of biomineral tissue development	Any process that modulates the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.		hp.json		http://purl.obolibrary.org/obo/GO_0070167		
GO:0070168	biolink:BiologicalProcess	negative regulation of biomineral tissue development	Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.		hp.json		http://purl.obolibrary.org/obo/GO_0070168		
GO:0070166	biolink:BiologicalProcess	enamel mineralization	The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited in tooth enamel.		hp.json	enamel formation	http://purl.obolibrary.org/obo/GO_0070166		
GO:0070192	biolink:BiologicalProcess	chromosome organization involved in meiotic cell cycle	A process of chromosome organization that is involved in a meiotic cell cycle.		hp.json	chromosome organisation involved in meiosis|meiotic chromosome organization	http://purl.obolibrary.org/obo/GO_0070192		
HP:0007509	biolink:PhenotypicFeature	Patchy hypo- and hyperpigmentation		UMLS:C4021573	hp.json	Patchy hypo- and hyper-pigmentation	http://purl.obolibrary.org/obo/HP_0007509		
HP:0007506	biolink:PhenotypicFeature	Congenital absence of skin of limbs		UMLS:C4024858	hp.json	Missing skin on limbs since birth	http://purl.obolibrary.org/obo/HP_0007506		
GO:0033162	biolink:CellularComponent	melanosome membrane	The lipid bilayer surrounding a melanosome.		hp.json		http://purl.obolibrary.org/obo/GO_0033162		
HP:0007505	biolink:PhenotypicFeature	Progressive hyperpigmentation		UMLS:C4024859	hp.json		http://purl.obolibrary.org/obo/HP_0007505		
HP:0007508	biolink:PhenotypicFeature	Punctate palmar hyperkeratosis	Tiny bumps of thickened skin (hyperkeratosis) on the palms of the hands.	UMLS:C4024857	hp.json		http://purl.obolibrary.org/obo/HP_0007508		
HP:0007502	biolink:PhenotypicFeature	Follicular hyperkeratosis	A skin condition characterized by excessive development of keratin in hair follicles, resulting in rough, cone-shaped, elevated papules resulting from closure of hair follicles with a white plug of sebum.	SNOMEDCT_US:402341008|SNOMEDCT_US:238629004|UMLS:C0334013|SNOMEDCT_US:81845009	hp.json	Hyperkeratosis follicularis	http://purl.obolibrary.org/obo/HP_0007502		hposlim_core
HP:0007501	biolink:PhenotypicFeature	Streaks of hyperkeratosis along each finger onto the palm		UMLS:C4024861	hp.json		http://purl.obolibrary.org/obo/HP_0007501		
HP:0007504	biolink:PhenotypicFeature	Diffuse slow skin atrophy		UMLS:C4024860	hp.json		http://purl.obolibrary.org/obo/HP_0007504		
HP:0007503	biolink:PhenotypicFeature	Generalized ichthyosis		UMLS:C3552528	hp.json	Generalised ichthyosis	http://purl.obolibrary.org/obo/HP_0007503		
HP:0007500	biolink:PhenotypicFeature	Decreased number of sweat glands	The presence of fewer than normal sweat glands.	UMLS:C4021574	hp.json	Decreased sweat glands|Decreased sweat pores	http://purl.obolibrary.org/obo/HP_0007500		
NCBITaxon:33213	biolink:OrganismalEntity	Bilateria		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_33213		
GO:0070199	biolink:BiologicalProcess	establishment of protein localization to chromosome	The directed movement of a protein to a specific location on a chromosome.		hp.json	establishment of protein localisation to chromosome	http://purl.obolibrary.org/obo/GO_0070199		
HP:0007517	biolink:PhenotypicFeature	Palmoplantar cutis laxa	Loose, wrinkled skin of hands and feet.	UMLS:C1856714	hp.json	Wrinkled skin of hands and feet|Wrinkled palms and soles|Furrowed palms and soles|Increased wrinkles of palms and soles|Excessive wrinkled skin of palms and soles	http://purl.obolibrary.org/obo/HP_0007517		
HP:0007516	biolink:PhenotypicFeature	Redundant skin on fingers	Loose and sagging skin of the fingers.	UMLS:C4024856	hp.json	Extra skin on fingers	http://purl.obolibrary.org/obo/HP_0007516		
HP:0007519	biolink:PhenotypicFeature	obsolete Lack of subcutaneous fatty tissue			hp.json		http://purl.obolibrary.org/obo/HP_0007519		
HP:0007513	biolink:PhenotypicFeature	Generalized hypopigmentation		UMLS:C1849923	hp.json	Generalised hypopigmentation|Pale pigmentation|Fair skin	http://purl.obolibrary.org/obo/HP_0007513		hposlim_core
HP:0007515	biolink:PhenotypicFeature	Hypoplastic pilosebaceous units		UMLS:C1832454	hp.json		http://purl.obolibrary.org/obo/HP_0007515		
NCBITaxon:33208	biolink:OrganismalEntity	Metazoa		GC_ID:1	hp.json	metazoans|animals|multicellular animals|Animalia|metazoan-	http://purl.obolibrary.org/obo/NCBITaxon_33208		
HP:0007514	biolink:PhenotypicFeature	Edema of the dorsum of hands	An abnormal accumulation of fluid beneath the skin on the back of the hands.	UMLS:C2751873|SNOMEDCT_US:443710002|UMLS:C2732374|MEDDRA:10058204	hp.json	Oedema of the dorsum of hands|Edema of dorsum of hands|Oedema of dorsum of hands	http://purl.obolibrary.org/obo/HP_0007514		
HP:0007511	biolink:PhenotypicFeature	Mottled pigmentation of photoexposed areas		UMLS:C3151964	hp.json		http://purl.obolibrary.org/obo/HP_0007511		
HP:0007510	biolink:PhenotypicFeature	Focal dermal aplasia/hypoplasia		UMLS:C1834069	hp.json		http://purl.obolibrary.org/obo/HP_0007510		
GO:0033157	biolink:BiologicalProcess	regulation of intracellular protein transport	Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.		hp.json		http://purl.obolibrary.org/obo/GO_0033157		
GO:0008188	biolink:MolecularActivity	neuropeptide receptor activity	Combining with a neuropeptide to initiate a change in cell activity.		hp.json		http://purl.obolibrary.org/obo/GO_0008188		
CARO:0030000	biolink:NamedThing	biological entity			hp.json		http://purl.obolibrary.org/obo/CARO_0030000		
GO:1901608	biolink:BiologicalProcess	regulation of vesicle transport along microtubule	Any process that modulates the frequency, rate or extent of vesicle transport along microtubule.		hp.json	regulation of microtubule-based vesicle localization	http://purl.obolibrary.org/obo/GO_1901608		
GO:1901609	biolink:BiologicalProcess	negative regulation of vesicle transport along microtubule	Any process that stops, prevents or reduces the frequency, rate or extent of vesicle transport along microtubule.		hp.json	down regulation of vesicle transport along microtubule|down regulation of microtubule-based vesicle localization|inhibition of vesicle transport along microtubule|down-regulation of microtubule-based vesicle localization|negative regulation of microtubule-based vesicle localization|downregulation of vesicle transport along microtubule|inhibition of microtubule-based vesicle localization|down-regulation of vesicle transport along microtubule|downregulation of microtubule-based vesicle localization	http://purl.obolibrary.org/obo/GO_1901609		
CHEBI:24400	biolink:ChemicalSubstance	glycoside	A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively.		hp.json	glycosides|glycosides|O-glycosides|O-glycoside	http://purl.obolibrary.org/obo/CHEBI_24400		3_STAR
GO:1901607	biolink:BiologicalProcess	alpha-amino acid biosynthetic process	The chemical reactions and pathways resulting in the formation of an alpha-amino acid.		hp.json	alpha-amino acid anabolism|alpha-amino acid synthesis|alpha-amino acid formation|alpha-amino acid biosynthesis	http://purl.obolibrary.org/obo/GO_1901607		
GO:1901605	biolink:BiologicalProcess	alpha-amino acid metabolic process	The chemical reactions and pathways involving an alpha-amino acid.		hp.json	alpha-amino acid metabolism	http://purl.obolibrary.org/obo/GO_1901605		
CHEBI:24403	biolink:ChemicalSubstance	glycosyl group	An organic group obtained by removing the hydroxy group from the hemiacetal function of a monosaccharide or monosaccharide derivative and, by extension, of a lower oligosaccharide or oligosaccharide derivative.		hp.json	glycosyl groups|glycosyl group|groupe glycosyle	http://purl.obolibrary.org/obo/CHEBI_24403		3_STAR
CHEBI:24402	biolink:ChemicalSubstance	glycosphingolipid	A glycosphingolipid is a glycolipid that is a carbohydrate-containing derivative of a sphingoid or ceramide. It is understood that the carbohydrate residue is attached by a glycosidic linkage to O-1 of the sphingoid.	PMID:19303901|PMID:18845618|PMID:27325407|Wikipedia:Glycosphingolipid|PMID:26976737|PMID:26954668|PMID:27253729	hp.json	glycosphingolipids	http://purl.obolibrary.org/obo/CHEBI_24402		3_STAR
GO:0045111	biolink:NamedThing	intermediate filament cytoskeleton			hp.json		http://purl.obolibrary.org/obo/GO_0045111		
UBERON:0001271	biolink:AnatomicalEntity	pelvic girdle region	The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pelvic girdle regions.	FMA:16581|VSAO:0000304|EMAPA:37862|SCTID:360010001|UMLS:C0684083|NCIT:C33291	hp.json	girdle - pelvic|pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0001271		vertebrate_core|uberon_slim
UBERON:0001270	biolink:AnatomicalEntity	bony pelvis	A ring of bone formed by the sacrum and the first few coccygeal vertebrae as the roof, the pubis and ischia as the floor and the ilia and the acetabular part of the ischia as the walls.	FMA:16580	hp.json	pelvis ossea|skeletal system of pelvis	http://purl.obolibrary.org/obo/UBERON_0001270		
UBERON:0001273	biolink:AnatomicalEntity	ilium	Paired endochondral bone that is the dorsal-most of the pelvic bones, offering attachment areas for gluteal muscles on its main surface [PHENOSCAPE:ad].	MA:0001336|galen:Ilium|OpenCyc:Mx4rvhwFJ5wpEbGdrcN5Y29ycA|CALOHA:TS-2200|NCIT:C32765|MESH:D007085|UMLS:C0020889|AAO:0000772|EFO:0003049|EMAPA:18726|GAID:207|FMA:16589	hp.json	os ilii|iliac bone|os ilium|ilium bone|os iliacum|illium	http://purl.obolibrary.org/obo/UBERON_0001273		pheno_slim|efo_slim|uberon_slim
UBERON:0001272	biolink:AnatomicalEntity	innominate bone	A fused bone consisting of the ilium, ischium and pubis. Together with the sacrum and coccyx, it comprises the pelvis. [WP,modified].	FMA:16585|GAID:205	hp.json	pelvic bone|os coxae|innominate|hip bone|basipterygium|os coxa|os innominatum|innominate bone|coxal bone|bone of pelvic girdle	http://purl.obolibrary.org/obo/UBERON_0001272		uberon_slim
UBERON:0001279	biolink:AnatomicalEntity	portal triad	A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel.	FMA:17523|MA:0002499|UMLS:C0227514|NCIT:C33342	hp.json	trias hepatica|trias hepatica	http://purl.obolibrary.org/obo/UBERON_0001279		uberon_slim|pheno_slim|human_reference_atlas
UBERON:0001278	biolink:AnatomicalEntity	epithelium of large intestine	An epithelium that is part of a large intestine [Automatically generated definition].	MA:0001545|FMA:17301|CALOHA:TS-2105|EMAPA:35466	hp.json	epithelial tissue of large intestine|large intestine epithelial tissue|large intestinal epithelium|large intestine epithelium	http://purl.obolibrary.org/obo/UBERON_0001278		
GO:0060759	biolink:BiologicalProcess	regulation of response to cytokine stimulus	Any process that modulates the rate, frequency, or extent of a response to cytokine stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0060759		
PR:P06332	biolink:Protein	T-cell surface glycoprotein CD4 (mouse)	A CD4 molecule that is encoded in the genome of mouse.	UniProtKB:P06332	hp.json	Cd4|CD4 (mouse)|mCD4|T-cell surface antigen T4/Leu-3 (mouse)|T-cell differentiation antigen L3T4 (mouse)	http://purl.obolibrary.org/obo/PR_P06332		
UBERON:0001275	biolink:AnatomicalEntity	pubis	A paired endochondral bone making up the anteroventral region of the tripartite pelvic girdle forming part of the ventral edge of the acetabulum. The origin site of many proximal hindlimb muscles. [PHENOSCAPE:ad].	NCIT:C33423|FMA:16595|UMLS:C0034014|MESH:D011630|AAO:0000861|galen:Pubis|EMAPA:18728|MA:0001338	hp.json	os pubis|pubis bone|pubic bone	http://purl.obolibrary.org/obo/UBERON_0001275		pheno_slim|uberon_slim
UBERON:0001274	biolink:AnatomicalEntity	ischium	Endochondral bone that is paired, forming the posterior part of the pelvis, articulating with the pubis and ilium.	NCIT:C32884|UMLS:C0022122|FMA:16592|AAO:0000860|MESH:D007512|GAID:208|EMAPA:18727|galen:Ischium|VSAO:0005006|OpenCyc:Mx4rvlzMKpwpEbGdrcN5Y29ycA|MA:0001337	hp.json	os ischii|os ischii|ischial bone|ischium bone	http://purl.obolibrary.org/obo/UBERON_0001274		pheno_slim|uberon_slim
UBERON:0001277	biolink:AnatomicalEntity	intestinal epithelium	Epithelial layer that lines the intestine.	MA:0001536|NCIT:C49240|Wikipedia:Intestinal_epithelium|ZFA:0005124|SCTID:266135004|UMLS:C0226890|TAO:0005124|EMAPA:32873|FMA:17229|BTO:0000781	hp.json	epithelium of bowel|epithelial tissue of bowel|villous epithelium|bowel epithelial tissue|intestine epithelium|epithelium of intestine|bowel epithelium|epithelial tissue of intestine|intestine epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0001277		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001276	biolink:AnatomicalEntity	epithelium of stomach	The epithelial layer of the stomach .	MA:0001610|CALOHA:TS-2068|EMAPA:17023|BTO:0000500|EHDAA2:0001918|VHOG:0001433|SCTID:64977002|FMA:17091	hp.json	stomach epithelial tissue|stomach epithelium|ventriculus epithelium|epithelium of ventriculus|gastric epithelium|epithelial tissue of ventriculus|ventriculus epithelial tissue|epithelial tissue of stomach	http://purl.obolibrary.org/obo/UBERON_0001276		pheno_slim
UBERON:0013240	biolink:AnatomicalEntity	future glans clitoris	A future glans that is part of a female genital tubercle.	EMAPA:19170	hp.json	glans of female genital tubercle	http://purl.obolibrary.org/obo/UBERON_0013240		
GO:1901617	biolink:BiologicalProcess	organic hydroxy compound biosynthetic process	The chemical reactions and pathways resulting in the formation of organic hydroxy compound.		hp.json	organic hydroxy compound anabolism|organic hydroxy compound synthesis|organic hydroxy compound formation|organic hydroxy compound biosynthesis	http://purl.obolibrary.org/obo/GO_1901617		
UBERON:0013241	biolink:AnatomicalEntity	embryonic urethral groove	The precursor of the urethra.		hp.json	urethral groove|sulcus urethralis primarius|urethral sulcus	http://purl.obolibrary.org/obo/UBERON_0013241		
GO:1901615	biolink:BiologicalProcess	organic hydroxy compound metabolic process	The chemical reactions and pathways involving organic hydroxy compound.		hp.json	organic hydroxy compound metabolism	http://purl.obolibrary.org/obo/GO_1901615		
UBERON:0013247	biolink:AnatomicalEntity	male paramesonephric duct	An epithelial tube that develops from a Mullerian duct in a male. Later degenerates.	EHDAA2:0001052|EMAPA:35661|EMAPA:29161	hp.json	degenerating mesonephric portion of male paramesonephric duct	http://purl.obolibrary.org/obo/UBERON_0013247		
GO:1901610	biolink:BiologicalProcess	positive regulation of vesicle transport along microtubule	Any process that activates or increases the frequency, rate or extent of vesicle transport along microtubule.		hp.json	up regulation of vesicle transport along microtubule|activation of vesicle transport along microtubule|positive regulation of microtubule-based vesicle localization|up regulation of microtubule-based vesicle localization|upregulation of vesicle transport along microtubule|up-regulation of microtubule-based vesicle localization|activation of microtubule-based vesicle localization|upregulation of microtubule-based vesicle localization|up-regulation of vesicle transport along microtubule	http://purl.obolibrary.org/obo/GO_1901610		
GO:0045124	biolink:BiologicalProcess	regulation of bone resorption	Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).		hp.json		http://purl.obolibrary.org/obo/GO_0045124		
UBERON:0037237	biolink:AnatomicalEntity	wall of lacrimal duct		FMA:85375	hp.json	lacrimal ductal wall	http://purl.obolibrary.org/obo/UBERON_0037237		
UBERON:0001260	biolink:AnatomicalEntity	serosa of urinary bladder	A serous membrane that is part of a urinary bladder [Automatically generated definition].	MA:0001696|EMAPA:28661|FMA:15932	hp.json	urinary bladder serous membrane|tunica serosa (vesica urinaria)|serous coat of urinary bladder|serosa of bladder|serous membrane of urinary bladder|bladder serous membrane|bladder serosa|tunica serosa vesicae|serous coat of bladder|visceral peritoneum of urinary bladder|serous membrane of bladder|urinary bladder serosa	http://purl.obolibrary.org/obo/UBERON_0001260		
UBERON:0001262	biolink:AnatomicalEntity	wall of intestine	An anatomical wall that is part of a intestine [Automatically generated definition].	UMLS:C1708548|BTO:0000647|FMA:15949|MA:0002693|NCIT:C49478|EMAPA:35444|MA:0001525	hp.json	anatomical wall of bowel|intestine anatomical wall|intestine wall|wall of bowel|anatomical wall of intestine|bowel wall|bowel anatomical wall|bowel wall|intestinal wall	http://purl.obolibrary.org/obo/UBERON_0001262		
UBERON:0001261	biolink:AnatomicalEntity	lamina propria of urinary bladder	A lamina propria that is part of a urinary bladder [Automatically generated definition].	UMLS:C1706967|MA:0001695|NCIT:C48940|FMA:15935|EMAPA:30088	hp.json	urinary bladder lamina propria|lamina propria of bladder|lamina propria mucosae of bladder|bladder lamina propria mucosa|bladder lamina propria mucosae|lamina propria mucosa of urinary bladder|bladder lamina propria|lamina propria mucosa of bladder|urinary bladder lamina propria mucosae|lamina propria mucosae of urinary bladder|urinary bladder lamina propria mucosa	http://purl.obolibrary.org/obo/UBERON_0001261		human_reference_atlas
UBERON:0013239	biolink:AnatomicalEntity	future glans penis	A future glans that is part of a male genital tubercle.	EMAPA:29252	hp.json	glans of male genital tubercle	http://purl.obolibrary.org/obo/UBERON_0013239		
UBERON:0001268	biolink:AnatomicalEntity	peritoneal fluid	Transudate contained in the peritoneal cavity.	BTO:0001031|EMAPA:35683|MA:0002531|ncithesaurus:Peritoneal_Fluid|Wikipedia:Peritoneal_fluid|FMA:16515	hp.json		http://purl.obolibrary.org/obo/UBERON_0001268		uberon_slim|pheno_slim
UBERON:0001267	biolink:AnatomicalEntity	femoral nerve	The femoral nerve, the largest branch of the lumbar plexus, arises from the ventral divisions of the second, third, and fourth lumbar nerves. It descends through the fibers of the Psoas major, emerging from the muscle at the lower part of its lateral border, and passes down between it and the Iliacus, behind the iliac fascia; it then runs beneath the inguinal ligament, into the thigh, and splits into an anterior and a posterior division. Under the inguinal ligament, it is separated from the femoral artery by a portion of the Psoas major. [WP,unvetted].	EHDAA2:0000507|VHOG:0001411|UMLS:C0015808|EMAPA:35343|GAID:850|FMA:16486|MA:0001167|EHDAA:5655|NCIT:C52816|OpenCyc:Mx4rwGC03JwpEbGdrcN5Y29ycA|MESH:D005267	hp.json	nervus femoralis|anterior crural nerve	http://purl.obolibrary.org/obo/UBERON_0001267		uberon_slim
UBERON:0001269	biolink:AnatomicalEntity	acetabular part of hip bone	The acetabulum is a concave surface of the pelvis. The head of the femur meets with the pelvis at the acetabulum, forming the hip joint. There are three bones of the os coxae (hip bone) that come together to form the acetabulum. Contributing a little more than two-fifths of the structure is the ischium, which provides lower and side boundaries to the acetabulum. The ilium forms the upper boundary, providing a little less than two-fifths of the structure of the acetabulum. The rest is formed by the pubis, near the midline. It is bounded by a prominent uneven rim, which is thick and strong above, and serves for the attachment of the acetabular labrum, which reduces its opening, and deepens the surface for formation of the hip joint. At the lower part of the acetabulum is the acetabular notch, which is continuous with a circular depression, the acetabular fossa, at the bottom of the cavity of the acetabulum. The rest of the acetabulum is formed by a curved, crescent-moon shaped surface, the lunate surface, where the joint is made with the head of the femur. Its counterpart in the pectoral girdle is the glenoid fossa.[WP,unvetted].	GAID:206|FMA:16579|EMAPA:18346|MA:0001335|OpenCyc:Mx4rwJlP9ZwpEbGdrcN5Y29ycA|UMLS:C0000962|EHDAA:10661|MESH:D000077|NCIT:C32042|VHOG:0000974|RETIRED_EHDAA2:0001427|AAO:0000770	hp.json	acetabulum|acetabular region	http://purl.obolibrary.org/obo/UBERON_0001269		uberon_slim|pheno_slim
UBERON:0001264	biolink:AnatomicalEntity	pancreas	An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO].	MIAA:0000075|XAO:0000136|EV:0100092|GAID:334|BTO:0000988|EFO:0000855|UMLS:C0030274|MESH:D010179|VHOG:0000050|EHDAA2:0001367|galen:Pancreas|FMA:7198|MA:0000120|AAO:0010112|ZFA:0000140|CALOHA:TS-0736|OpenCyc:Mx4rvVimZZwpEbGdrcN5Y29ycA|EHDAA:6893|TAO:0000140|MAT:0000075|NCIT:C12393|EMAPA:17503	hp.json		http://purl.obolibrary.org/obo/UBERON_0001264		uberon_slim|vertebrate_core|major_organ|organ_slim|pheno_slim|human_reference_atlas|efo_slim
UBERON:0001263	biolink:AnatomicalEntity	pancreatic acinus	The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct.	EMAPA:35651|UMLS:C0227578|FMA:16011|NCIT:C49268|MA:0002417	hp.json	pancreatic acinar|pancreas acinus|pancreatic acini|acinus pancreaticus	http://purl.obolibrary.org/obo/UBERON_0001263		pheno_slim|human_reference_atlas
UBERON:0001265	biolink:AnatomicalEntity	trabecula of spleen	A trabecula that is part of a spleen.	FMA:16027|EMAPA:35808|UMLS:C0229688|MA:0000758|NCIT:C33607	hp.json	splenic trabecula|spleen trabeculum|trabeculae of spleen	http://purl.obolibrary.org/obo/UBERON_0001265		human_reference_atlas
UBERON:0001249	biolink:AnatomicalEntity	spleen lymphoid follicle	The area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur.	UMLS:C1519475|NCIT:C33602|EMAPA:35804|MA:0002672	hp.json	splenic B cell follicle|splenic lymphatic follicle|spleen B cell follicle|spleen lymphoid follicle|lymphoid follicle of spleen|lymphoid nodule of spleen|lymphatic follicle of spleen|Malpighian body|splenic lymphoid follicle|spleen lymphoid nodule	http://purl.obolibrary.org/obo/UBERON_0001249		pheno_slim
GO:1901624	biolink:BiologicalProcess	negative regulation of lymphocyte chemotaxis	Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte chemotaxis.		hp.json	down-regulation of lymphocyte chemotaxis|down regulation of lymphocyte chemotaxis|inhibition of lymphocyte chemotaxis|downregulation of lymphocyte chemotaxis	http://purl.obolibrary.org/obo/GO_1901624		
UBERON:0013235	biolink:AnatomicalEntity	ventrum	A major organism subdivisionthat is the entire part of an anatomical structure ventral to a horizontal plane and bounded on one side by the same horizontal plane.	FMA:259204	hp.json	ventral region of organism|ventral part of organism|ventral region|front of body proper|front	http://purl.obolibrary.org/obo/UBERON_0013235		
GO:1901623	biolink:BiologicalProcess	regulation of lymphocyte chemotaxis	Any process that modulates the frequency, rate or extent of lymphocyte chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_1901623		
GO:0045136	biolink:BiologicalProcess	development of secondary sexual characteristics	The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.		hp.json		http://purl.obolibrary.org/obo/GO_0045136		
UBERON:0013238	biolink:AnatomicalEntity	future glans			hp.json		http://purl.obolibrary.org/obo/UBERON_0013238		
GO:0045137	biolink:BiologicalProcess	development of primary sexual characteristics	The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.		hp.json		http://purl.obolibrary.org/obo/GO_0045137		
UBERON:0013231	biolink:AnatomicalEntity	sebaceous gland of eyelid	Any of the sebaceous glands that are in the eyelid. Examples: gland of Zeis (services eyelashes), gland of Meibom (tarsal gland - unconnected to eyelids).		hp.json		http://purl.obolibrary.org/obo/UBERON_0013231		
UBERON:0013232	biolink:AnatomicalEntity	serous acinus	The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells.	FMA:86279	hp.json	acinus of serous gland	http://purl.obolibrary.org/obo/UBERON_0013232		
GO:0045132	biolink:BiologicalProcess	meiotic chromosome segregation	The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.		hp.json		http://purl.obolibrary.org/obo/GO_0045132		
UBERON:0013228	biolink:AnatomicalEntity	sweat gland of eyelid	Glands of Moll, also known as ciliary glands, are modified apocrine sweat glands that are found on the margin of the eyelid. They are next to the base of the eyelashes, and anterior to the Meibomian glands within the distal eyelid margin. These glands are relatively large and tubular-shaped. The glands of Moll are named after Dutch oculist Jacob Anton Moll (1832-1914). Glands of Moll empty into the adjacent lashes. Glands of Moll and Zeis secrete lipid that adds to the superficial layer of the tear film, retarding evaporation. The glands of Moll are prone to infection and blockage of its duct with sebum and cell debris. Blockage of the gland's duct causes swelling which can manifest itself as a stye.	FMA:59159|NCIT:C32679	hp.json	ciliary gland|ciliary gland of moll|Moll's gland|gland of Moll|ciliary sweat gland of eyelid	http://purl.obolibrary.org/obo/UBERON_0013228		
UBERON:0013229	biolink:AnatomicalEntity	eyelid gland	Any gland that is part of an eyelid. This includes sebaceous glands (Zeis gland, tarsal gland) and sweat glands (Moll's gland).		hp.json	gland of eyelid	http://purl.obolibrary.org/obo/UBERON_0013229		
UBERON:0025261	biolink:AnatomicalEntity	thalamic fiber tract		BIRNLEX:749	hp.json	thalamic fiber tracts|thalamic fiber tracts	http://purl.obolibrary.org/obo/UBERON_0025261		
UBERON:0001256	biolink:AnatomicalEntity	wall of urinary bladder	An anatomical wall that lines the insider of a urinary bladder.	BTO:0001462|EMAPA:35175|UMLS:C0458421|NCIT:C48941|FMA:15902|MA:0002493	hp.json	anatomical wall of bladder|urinary bladder anatomical wall|wall of bladder|urinary bladder wall|bladder anatomical wall|anatomical wall of urinary bladder|bladder wall	http://purl.obolibrary.org/obo/UBERON_0001256		pheno_slim|human_reference_atlas
UBERON:0001259	biolink:AnatomicalEntity	mucosa of urinary bladder	The mucous membrane lining the urinary bladder.	EMAPA:35897|EFO:0000293|NCIT:C32205|UMLS:C0227691|FMA:15928|galen:MucousMembraneOfUrinaryBladder|MA:0001692	hp.json	tunica mucosa vesicae|bladder mucous membrane|mucous membrane of urinary bladder|bladder organ mucosa|bladder mucosa|tunica mucosa (vesica urinaria)|tunica mucosa vesicae urinariae|urinary bladder mucous membrane|mucosa of bladder|mucous membrane of bladder|urinary bladder mucosa	http://purl.obolibrary.org/obo/UBERON_0001259		efo_slim|human_reference_atlas|pheno_slim
UBERON:0001258	biolink:AnatomicalEntity	neck of urinary bladder	The constricted portion of the urinary bladder, formed by the meeting of its inferolateral surfaces proximal to the opening of the urethra[MP].	MA:0002491|UMLS:C0227716|EMAPA:36078|NCIT:C12336|galen:UrinaryBladderNeck|FMA:15912	hp.json	vesical neck|urinary bladder neck|neck of bladder|bladder neck|cervix vesicae|cervix vesicae urinariae|collum vesicae	http://purl.obolibrary.org/obo/UBERON_0001258		uberon_slim|pheno_slim
UBERON:0001253	biolink:AnatomicalEntity	lamina propria of ureter	A lamina propria that is part of a ureter [Automatically generated definition].	FMA:15896|EMAPA:28841|MA:0002653	hp.json	ureter lamina propria|ureter lamina propria mucosa|lamina propria mucosae of ureter|lamina propria mucosa of ureter|ureter lamina propria mucosae	http://purl.obolibrary.org/obo/UBERON_0001253		human_reference_atlas
UBERON:0001252	biolink:AnatomicalEntity	adventitia of ureter	An adventitia that is part of a ureter.	EMAPA:28114|FMA:15892|MA:0002652	hp.json	external adventitia of ureter|tunica adventitia (ureter)|ureter adventitia|tunica adventitia ureteris|ureteral adventitia	http://purl.obolibrary.org/obo/UBERON_0001252		
UBERON:0001255	biolink:AnatomicalEntity	urinary bladder	Distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP].	CALOHA:TS-1090|UMLS:C0005682|MIAA:0000122|VHOG:0000740|OpenCyc:Mx4rvVjMmZwpEbGdrcN5Y29ycA|GAID:0000004|NCIT:C12414|galen:UrinaryBladder|BTO:0001418|EFO:0000290|XAO:0000154|AAO:0000623|MESH:D001743|EMAPA:18321|EHDAA:9328|MAT:0000122|FMA:15900|EHDAA2:0000174|MA:0000380|EV:0100098	hp.json	vesica|urocyst|vesica urinaria|bladder	http://purl.obolibrary.org/obo/UBERON_0001255		uberon_slim|major_organ|organ_slim|pheno_slim|human_reference_atlas|efo_slim
CHEBI:73398	biolink:ChemicalSubstance	indole skeleton	A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring.		hp.json		http://purl.obolibrary.org/obo/CHEBI_73398		3_STAR
UBERON:0001238	biolink:AnatomicalEntity	lamina propria of small intestine	Lamina propria that is part_of the small intestine.	EMAPA:35779|NCIT:C49297|UMLS:C1711325|FMA:15651|MA:0001554	hp.json	lamina propria mucosa of small bowel|lamina propria mucosae of small intestine|small intestine lamina propria mucosa|small bowel lamina propria mucosae|lamina propria of small bowel|small bowel lamina propria|lamina propria mucosae of small bowel|lamina propria mucosa of small intestine|lamina propria of mucosa of small intestine|small bowel lamina propria mucosa|small intestine lamina propria mucosae|small intestine lamina propria	http://purl.obolibrary.org/obo/UBERON_0001238		
GO:0060760	biolink:BiologicalProcess	positive regulation of response to cytokine stimulus	Any process that increases the rate, frequency, or extent of a response to cytokine stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0060760		
GO:0060761	biolink:BiologicalProcess	negative regulation of response to cytokine stimulus	Any process that decreases the rate, frequency, or extent of a response to cytokine stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0060761		
GO:0060764	biolink:BiologicalProcess	cell-cell signaling involved in mammary gland development	Any process that mediates the transfer of information from one cell to another and contributes to the progression of the mammary gland, from its initial state to the mature structure.		hp.json	cell-cell signalling involved in mammary gland development	http://purl.obolibrary.org/obo/GO_0060764		
UBERON:0001246	biolink:AnatomicalEntity	interlobular bile duct	The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad.	NCIT:C32827|FMA:15767|MA:0002668|UMLS:C0227515	hp.json	interlobular ductule	http://purl.obolibrary.org/obo/UBERON_0001246		pheno_slim
UBERON:0001245	biolink:AnatomicalEntity	anus	Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts.	UMLS:C0003461|FMA:15711|TADS:0000066|CALOHA:TS-2005|BTO:0001680|EV:0100082|TGMA:0001279|GAID:312|WBbt:0005364|OpenCyc:Mx4rvVjaEZwpEbGdrcN5Y29ycA|Wikipedia:Anus|MESH:A03.492.411.495.767.288|MA:0000331|SCTID:181262009|galen:Anus|FBbt:00047153|NCIT:C43362	hp.json	proctodeum|anal orifice|anal opening|opening of terminal part of digestive tract	http://purl.obolibrary.org/obo/UBERON_0001245		human_reference_atlas|uberon_slim|pheno_slim
UBERON:0001247	biolink:AnatomicalEntity	falciform ligament	A ligament that attaches the liver to the anterior body wall. It is a broad and thin antero-posterior peritoneal fold, falciform in shape, its base being directed downward and backward and its apex upward and backward. It is a remnant of the ventral mesentery of the fetus. It is situated in an antero-posterior plane but lies obliquely, so that one surface faces forward and is in contact with the peritoneum behind the right rectus and the diaphragm, while the other is directed backward and is in contact with the left lobe of the liver. It is attached by its left margin to the under surface of the diaphragm and the posterior surface of the sheath of the right Rectus as low down as the umbilicus; by its right margin it extends from the notch on the anterior margin of the liver, as far back as the posterior surface. It is composed of two layers of peritoneum closely united together. Its base or free edge contains between its layers the round ligament and the paraumbilical veins[WP].	FMA:15823|VHOG:0000355|MA:0001622|EHDAA:4856|EMAPA:18288|EHDAA2:0000499|UMLS:C0230240|NCIT:C32582	hp.json	falciform ligament of liver|ligamentum falciforme hepatis|ligamentum falciforme (hepatis)	http://purl.obolibrary.org/obo/UBERON_0001247		uberon_slim
UBERON:0001242	biolink:AnatomicalEntity	intestinal mucosa	Mucosal layer that lines the intestine.	MA:0001537|UMLS:C0021839|NCIT:C49241|EMAPA:35440|FMA:15695|SCTID:362080002|GAID:296|BTO:0000642|MESH:D007413	hp.json	tunica mucosa intestini|bowel mucous membrane|mucosa of organ of bowel|bowel mucosa|bowel organ mucosa|mucous membrane of intestine|organ mucosa of intestine|intestine mucosa of organ|mucosa of intestine|mucosa of organ of intestine|intestine mucous membrane|intestine organ mucosa|intestine mucosa|bowel mucosa of organ|mucous membrane of bowel|organ mucosa of bowel|mucosa of bowel	http://purl.obolibrary.org/obo/UBERON_0001242		uberon_slim|pheno_slim
UBERON:0001243	biolink:AnatomicalEntity	serosa of intestine	A serous membrane that is part of a wall of intestine [Automatically generated definition].	FMA:15701|MA:0001538|EMAPA:37619	hp.json	intestinal serosa|bowel anatomical wall serosa|visceral peritoneum of intestine|anatomical wall of intestine serosa|bowel wall serosa|wall of bowel serous membrane|serous membrane of intestinal wall|intestine serosa|serosa of bowel anatomical wall|serous membrane of intestine anatomical wall|serous membrane of anatomical wall of bowel|serosa of wall of intestine|serous membrane of intestine wall|wall of bowel serosa|bowel wall serous membrane|serosa of bowel wall|serosa of anatomical wall of intestine|serous membrane of wall of bowel|anatomical wall of intestine serous membrane|bowel anatomical wall serous membrane|intestine anatomical wall serosa|serosa of intestinal wall|intestine wall serosa|anatomical wall of bowel serosa|wall of intestine serous membrane|intestinal wall serosa|serosa of intestine anatomical wall|intestinal wall serous membrane|serous membrane of bowel anatomical wall|serous membrane of anatomical wall of intestine|serosa of wall of bowel|serous membrane of bowel wall|serous membrane of wall of intestine|intestine wall serous membrane|serosa of anatomical wall of bowel|anatomical wall of bowel serous membrane|serosa of intestine wall|wall of intestine serosa|intestine anatomical wall serous membrane	http://purl.obolibrary.org/obo/UBERON_0001243		
OBO:uberon/core#channels_into	biolink:NamedThing	channels_into			hp.json		http://purl.obolibrary.org/obo/uberon/core#channels_into		
GO:0060795	biolink:BiologicalProcess	cell fate commitment involved in formation of primary germ layer	The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.		hp.json		http://purl.obolibrary.org/obo/GO_0060795		
UBERON:0013280	biolink:AnatomicalEntity	diaphysis of tibia	A diaphysis that is part of a tibia.	FMA:33125|EMAPA:37770|MA:0003049	hp.json	body of tibia|shaft of tibia|shaft of tibia|body of the tibia|tibial diaphysis|corpus tibiae	http://purl.obolibrary.org/obo/UBERON_0013280		
GO:1901657	biolink:BiologicalProcess	glycosyl compound metabolic process	The chemical reactions and pathways involving glycosyl compound.		hp.json	glycosyl compound metabolism	http://purl.obolibrary.org/obo/GO_1901657		
GO:1901655	biolink:BiologicalProcess	cellular response to ketone	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_1901655		
GO:1901653	biolink:BiologicalProcess	cellular response to peptide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_1901653		
GO:1901654	biolink:BiologicalProcess	response to ketone	A response that results in a state of tolerance to ketone.		hp.json	process resulting in tolerance to ketone	http://purl.obolibrary.org/obo/GO_1901654		
UBERON:0039857	biolink:AnatomicalEntity	left ovarian vein	Ovarian vein, each instance of which is a tributary  of some left renal vein that drains the left pampiniform plexus of some broad ligament.	FMA:14347	hp.json		http://purl.obolibrary.org/obo/UBERON_0039857		
GO:1901652	biolink:BiologicalProcess	response to peptide	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_1901652		
GO:0045168	biolink:BiologicalProcess	cell-cell signaling involved in cell fate commitment	Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.		hp.json	cell-cell signaling resulting in cell fate commitment|cell-cell signaling during in cell fate commitment|cell fate commitment, cell-cell signalling|cell-cell signalling involved in cell fate specification|cell-cell signalling resulting in cell fate commitment|cell-cell signalling during cell fate commitment|cell fate commitment, cell-cell signaling	http://purl.obolibrary.org/obo/GO_0045168		
UBERON:0039856	biolink:AnatomicalEntity	right ovarian vein	Ovarian vein, each instance of which is a tributary  of some inferior vena cava that drains the right pampiniform plexus of some broad ligament.	FMA:14342	hp.json		http://purl.obolibrary.org/obo/UBERON_0039856		
GO:0045165	biolink:BiologicalProcess	cell fate commitment	The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.		hp.json		http://purl.obolibrary.org/obo/GO_0045165		
GO:0060784	biolink:BiologicalProcess	regulation of cell proliferation involved in tissue homeostasis	Any process that modulates the frequency, rate or extent of cell proliferation resulting in the maintenance of a steady-state number of cells within a tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0060784		
GO:0060785	biolink:BiologicalProcess	regulation of apoptosis involved in tissue homeostasis	Any process that modulates the occurrence or rate of cell death by apoptosis that results in the maintenance of the steady-state number of cells within a tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0060785		
GO:0060786	biolink:BiologicalProcess	regulation of cell differentiation involved in tissue homeostasis	Any process that modulates the frequency, rate or extent of cell differentiation that contributes to the maintenance of a steady state of a cell type within a tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0060786		
GO:0060788	biolink:BiologicalProcess	ectodermal placode formation	The developmental process in which an ectodermal placode forms. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.		hp.json		http://purl.obolibrary.org/obo/GO_0060788		
UBERON:4200230	biolink:AnatomicalEntity	surface of bone	An anatomical surface that is part of a bone.		hp.json	bone surface	http://purl.obolibrary.org/obo/UBERON_4200230		
UBERON:0013279	biolink:AnatomicalEntity	diaphysis of fibula	A diaphysis that is part of a fibula[Automatically generated definition].	FMA:33738|EMAPA:37892	hp.json	body of fibula|fibula diaphysis|corpus fibulae|shaft of fibula	http://purl.obolibrary.org/obo/UBERON_0013279		
GO:1901661	biolink:BiologicalProcess	quinone metabolic process	The chemical reactions and pathways involving quinone.		hp.json	quinone metabolism|quinone cofactor metabolic process|quinone cofactor metabolism	http://purl.obolibrary.org/obo/GO_1901661		
UBERON:0001295	biolink:AnatomicalEntity	endometrium	The glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy.	NCIT:C12313|EV:0100115|UMLS:C0014180|EMAPA:29917|BTO:0001422|SCTID:278867007|EFO:0000980|Wikipedia:Endometrium|MA:0000390|MAT:0000319|MESH:D004717|FMA:17742|CALOHA:TS-0276|VHOG:0001285|GAID:377|MIAA:0000319	hp.json	uterine mucous membrane|tunica mucosa uteri|uterine mucosa|tunica mucosa uteri|uterine endometrium|tunica mucosa (endometrium)	http://purl.obolibrary.org/obo/UBERON_0001295		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0001294	biolink:AnatomicalEntity	inner medulla of kidney	Innermost region of the mammalian kidney.	MA:0001652|BTO:0001745|CALOHA:TS-0506|EMAPA:28349|FMA:17734	hp.json	kidney inner medulla|zona interna (medullaris renalis)|zona interna medullae renalis|renal inner medulla|inner renal medulla|set of inner region of renal pyramids|inner zone of renal medulla|inner zone of medulla of kidney	http://purl.obolibrary.org/obo/UBERON_0001294		pheno_slim|human_reference_atlas
UBERON:0001297	biolink:AnatomicalEntity	serosa of uterus	Outer serosa layer of the uterus.	Wikipedia:Perimetrium|NCIT:C33298|MA:0001729|EMAPA:37792|UMLS:C0227824|FMA:17744|SCTID:253705006	hp.json	visceral peritoneum of uterus|serous coat of uterus|serous coat of uterus|uterine serosa|serous membrane of uterus|perimetrium|tunica serosa uteri|tunica serosa (perimetrium)|perimetrium|uterus serosa|uterus serous membrane	http://purl.obolibrary.org/obo/UBERON_0001297		
UBERON:0001299	biolink:AnatomicalEntity	glans penis	The conic expansion of the corpus spongiosum that forms the head of the penis.	FMA:18247|UMLS:C0227948|OpenCyc:Mx4rvdCpE5wpEbGdrcN5Y29ycA|GAID:0000012|NCIT:C12324|BTO:0003118|MA:0002726|EMAPA:18988|VHOG:0001475|EV:0100108	hp.json	balanus|coronal sulcus|glans	http://purl.obolibrary.org/obo/UBERON_0001299		pheno_slim|uberon_slim
GO:0045184	biolink:BiologicalProcess	establishment of protein localization	The directed movement of a protein to a specific location.		hp.json	protein recruitment|protein positioning|establishment of protein localisation	http://purl.obolibrary.org/obo/GO_0045184		
GO:0045182	biolink:MolecularActivity	translation regulator activity	Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.		hp.json	translation factor activity	http://purl.obolibrary.org/obo/GO_0045182		goslim_candida|goslim_generic|goslim_pir|goslim_plant|goslim_drosophila|goslim_aspergillus
GO:0045187	biolink:BiologicalProcess	regulation of circadian sleep/wake cycle, sleep	Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.		hp.json	regulation of sleep	http://purl.obolibrary.org/obo/GO_0045187		
UBERON:0001282	biolink:AnatomicalEntity	intralobular bile duct	The tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.	NCIT:C32255|MA:0002669|FMA:17545|UMLS:C0227517	hp.json	ductus interlobularis bilifer|canal of Hering|cholangiole|canals of Hering|intrahepatic bile ductule|duct of Herring|canal of Herring	http://purl.obolibrary.org/obo/UBERON_0001282		pheno_slim|uberon_slim
UBERON:0001281	biolink:AnatomicalEntity	hepatic sinusoid	Wide thin-walled blood vessels in the liver. In mammals they have neither veinous or arterial markers.	EMAPA:17365|TAO:0005091|UMLS:C0227523|EHDAA2:0000999|VHOG:0000708|NCIT:C32733|ZFA:0005091|FMA:17543|MA:0000367	hp.json	liver sinusoid|vas capillare sinusoideum|hepatic sinusoids|sinusoid of liver|vas sinusoideum|liver hepatic sinusoids|liver sinusoidal blood vessel|sinusoidal blood vessel of liver	http://purl.obolibrary.org/obo/UBERON_0001281		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
GO:1901681	biolink:MolecularActivity	sulfur compound binding	Binding to a sulfur compound.		hp.json	sulfur molecular entity binding	http://purl.obolibrary.org/obo/GO_1901681		
UBERON:0001280	biolink:AnatomicalEntity	liver parenchyma	The functional units of the liver including the lobules.	FMA:17540|VHOG:0000539|EHDAA:2201|EHDAA2:0001004|NCIT:C32735|XAO:0000454|AAO:0010405|EMAPA:17203|MA:0000366	hp.json	parenchyma of liver|hepatic parenchyma|hepatic parenchyme|liver parenchyme	http://purl.obolibrary.org/obo/UBERON_0001280		pheno_slim
UBERON:0001285	biolink:AnatomicalEntity	nephron	The basic functional unit of the kidney. its chief function is to regulate the concentration of water and soluble substances like sodium salts by filtering the blood, reabsorbing what is needed and excreting the rest as urine. A nephron eliminates wastes from the body, regulates blood volume and blood pressure, controls levels of electrolytes and metabolites, and regulates blood pH. Its functions are vital to life and are regulated by the endocrine system by hormones such as antidiuretic hormone, aldosterone, and parathyroid hormone.[WP].	BTO:0000924|FMA:17640|EMAPA:35592|MA:0000375|NCIT:C13048|EMAPA:28491|GAID:428|EV:0100384|TAO:0002153|ZFA:0005282|CALOHA:TS-1312|MESH:D009399|UMLS:C0027713	hp.json	nephroneum|mature nephron|tubulus renalis	http://purl.obolibrary.org/obo/UBERON_0001285		vertebrate_core|pheno_slim|human_reference_atlas|uberon_slim
HP:0500152	biolink:PhenotypicFeature	Hypocystinemia	A decreased amount of cystine in the blood.		hp.json	Low blood cystine levels|Decreased blood cystine concentration	http://purl.obolibrary.org/obo/HP_0500152		
HP:0500153	biolink:PhenotypicFeature	Hyperargininemia	An increased amount of arginine levels in the blood.		hp.json	Increased blood arginine concentration|High blood arginine levels	http://purl.obolibrary.org/obo/HP_0500153		
HP:0500150	biolink:PhenotypicFeature	Hypoglutamatemia	A decreased amount of glutamate in the blood.		hp.json	Decreased blood glutamate concentrations|Low blood glutamate levels	http://purl.obolibrary.org/obo/HP_0500150		
HP:0500151	biolink:PhenotypicFeature	Hypercystinemia	An increased amount of cystine in the blood.		hp.json	High blood cystine levels|Increased blood cystine concentraions	http://purl.obolibrary.org/obo/HP_0500151		
HP:0500156	biolink:PhenotypicFeature	Hyperasparaginemia	An increased amount of asparagine in the blood.		hp.json	Increased blood asparagine concentration|High blood asaparagine levels	http://purl.obolibrary.org/obo/HP_0500156		
HP:0500157	biolink:PhenotypicFeature	Hypoasparaginemia	A decreased amount of asparagine in the blood.		hp.json	Decreased blood asparagine concentration|Low blood asparagine levels	http://purl.obolibrary.org/obo/HP_0500157		
HP:0500154	biolink:PhenotypicFeature	Hypoalaninemia	A decreased amount of alanine in the blood.		hp.json	Low blood alanine levels|Decreased blood alanine concentration	http://purl.obolibrary.org/obo/HP_0500154		
HP:0500155	biolink:PhenotypicFeature	Abnormal circulating asparagine concentration	Any deviation from the normal concentration of asparagine in the blood circulation.		hp.json	Abnormality of asparagine metabolism	http://purl.obolibrary.org/obo/HP_0500155		
HP:0500158	biolink:PhenotypicFeature	Abnormal circulating aspartic acid concentration	Any deviation from the normal concentration of aspartate in the blood circulation.		hp.json	Abnormal circulating aspartate concentration	http://purl.obolibrary.org/obo/HP_0500158		
HP:0500159	biolink:PhenotypicFeature	Increased level of circulating aspartic acid	An increased amount of aspartic acid in the blood.		hp.json	Increased blood aspartic acid|High blood aspartic acid levels	http://purl.obolibrary.org/obo/HP_0500159		
GO:0060914	biolink:BiologicalProcess	heart formation	The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.		hp.json	cardiogenesis	http://purl.obolibrary.org/obo/GO_0060914		
GO:0060915	biolink:BiologicalProcess	mesenchymal cell differentiation involved in lung development	The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell of the lung. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.		hp.json		http://purl.obolibrary.org/obo/GO_0060915		
GO:0060916	biolink:BiologicalProcess	mesenchymal cell proliferation involved in lung development	The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population that contributes to the progression of the lung over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.		hp.json		http://purl.obolibrary.org/obo/GO_0060916		
HP:0500160	biolink:PhenotypicFeature	Abnormal circulating carnosine concentration	Any deviation from the normal concentration of carnosine in the blood circulation.		hp.json	Abnormality of carnosine metabolism	http://purl.obolibrary.org/obo/HP_0500160		
HP:0500141	biolink:PhenotypicFeature	Hypophenylalaninemia	A decreased amount of phenylalanine in the blood.		hp.json	Decreased blood phenylalanine|Low blood phenylalanine	http://purl.obolibrary.org/obo/HP_0500141		
HP:0500142	biolink:PhenotypicFeature	Hypolysinemia	A decreased amount of lysine in the blood.		hp.json	Decreased blood lysine|Low blood lysine levels	http://purl.obolibrary.org/obo/HP_0500142		
HP:0500140	biolink:PhenotypicFeature	Decreased circulating hydroxyproline concentration	A decreased amount of hydroxyproline in the blood.		hp.json	Decreased hydroxyproline in the blood|Low level of hydroxyproline in the blood	http://purl.obolibrary.org/obo/HP_0500140		
HP:0500145	biolink:PhenotypicFeature	Hypohistidinemia	A decreased amount of histidine in the blood.		hp.json	Low blood histidine levels|Decreased blood histidine concentration	http://purl.obolibrary.org/obo/HP_0500145		
HP:0500143	biolink:PhenotypicFeature	Hypoleucinemia	Decreased amount of leucine in the blood.		hp.json	Low blood leucine levels|Decreased blood concentration of leucine	http://purl.obolibrary.org/obo/HP_0500143		
HP:0500144	biolink:PhenotypicFeature	Hypoisoleucinemia	A decreased amount of isoleucine in the blood.		hp.json	Low blood isoleucine levels|Decreased blood isoleucine concentration	http://purl.obolibrary.org/obo/HP_0500144		
HP:0500149	biolink:PhenotypicFeature	Hyperglutamatemia	An increased amount of glutamate in the blood.		hp.json	High blood glutamate levels|Increased blood glutamate concentration	http://purl.obolibrary.org/obo/HP_0500149		
GO:0035935	biolink:BiologicalProcess	androgen secretion	The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates.		hp.json		http://purl.obolibrary.org/obo/GO_0035935		
HP:0500147	biolink:PhenotypicFeature	Hypoglutaminemia	Decreased amount of glutamine in the blood.		hp.json	Decreased blood glutamine concentration|Low blood glutamine level	http://purl.obolibrary.org/obo/HP_0500147		
HP:0500148	biolink:PhenotypicFeature	Abnormal circulating glutamate concentration	Any deviation from the normal concentration of glutamate in the blood circulation.		hp.json	Abnormality of glutamate metabolism	http://purl.obolibrary.org/obo/HP_0500148		
GO:0035930	biolink:NamedThing	corticosteroid hormone secretion			hp.json		http://purl.obolibrary.org/obo/GO_0035930		
GO:0035931	biolink:NamedThing	mineralocorticoid secretion			hp.json		http://purl.obolibrary.org/obo/GO_0035931		
GO:0035932	biolink:NamedThing	aldosterone secretion			hp.json		http://purl.obolibrary.org/obo/GO_0035932		
GO:0060900	biolink:BiologicalProcess	embryonic camera-type eye formation	The developmental process pertaining to the initial formation of a camera-type eye from unspecified neurectoderm. This process begins with the differentiation of cells that form the optic field and ends when the optic cup has attained its shape.		hp.json		http://purl.obolibrary.org/obo/GO_0060900		
GO:0060907	biolink:BiologicalProcess	positive regulation of macrophage cytokine production	Any process that increases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.		hp.json		http://purl.obolibrary.org/obo/GO_0060907		
HP:0500134	biolink:PhenotypicFeature	Hypertryptophanemia	An increased amount of tryptophan in the blood.		hp.json	Increased tryptophan in blood|High blood tryptophan concentration	http://purl.obolibrary.org/obo/HP_0500134		
HP:0500135	biolink:PhenotypicFeature	Hypotryptophanemia	A decreased amount of tryptophan in the blood.		hp.json	Low blood tryptophan concentration|Decreased tryptophan in blood	http://purl.obolibrary.org/obo/HP_0500135		
HP:0500132	biolink:PhenotypicFeature	Hypovalinemia	A decreased amount of valine in the blood.		hp.json	Low blood valine concentration	http://purl.obolibrary.org/obo/HP_0500132		
HP:0500133	biolink:PhenotypicFeature	Hypotyrosinemia	An decreased concentration of tyrosine in the blood.		hp.json	Decreased tyrosine in blood|Low blood tyrosine concentration	http://purl.obolibrary.org/obo/HP_0500133		
HP:0500138	biolink:PhenotypicFeature	Hyperserinemia	An increased amount of serine in the blood.		hp.json	High blood serine levels|Elevated circulating serine levels|Increased serine blood concentration	http://purl.obolibrary.org/obo/HP_0500138		
HP:0500139	biolink:PhenotypicFeature	Hypoprolinemia	A decreased amount of proline in the blood.		hp.json	Decreased blood proline levels|Low blood proline concentration	http://purl.obolibrary.org/obo/HP_0500139		
HP:0500136	biolink:PhenotypicFeature	Hypothreoninemia	A decreased amount of threonine in the blood.		hp.json	Decreased circulating threonine levels|Low blood threonine concentration|Decreased threonine blood levels	http://purl.obolibrary.org/obo/HP_0500136		
GO:0035929	biolink:BiologicalProcess	steroid hormone secretion	The regulated release of any steroid that acts as a hormone into the circulatory system.		hp.json		http://purl.obolibrary.org/obo/GO_0035929		
GO:0060931	biolink:BiologicalProcess	sinoatrial node cell development	The process whose specific outcome is the progression of a sinoatrial (SA) node cell over time, from its formation to the mature state. SA node cells are pacemaker cells that are found in the sinoatrial node.		hp.json	SA node cell development|SAN cell development|sinus node cell development	http://purl.obolibrary.org/obo/GO_0060931		
GO:0060932	biolink:BiologicalProcess	His-Purkinje system cell differentiation	The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the His-Purkinje system. These cells form the fibers regulate cardiac muscle contraction in the ventricles.		hp.json		http://purl.obolibrary.org/obo/GO_0060932		
GO:0060933	biolink:BiologicalProcess	His-Purkinje system cell development	The process whose specific outcome is the progression of a His-Purkinje cell over time, from its formation to the mature state. These cells form the fibers that regulate cardiac muscle contraction in the ventricles.		hp.json		http://purl.obolibrary.org/obo/GO_0060933		
GO:0060935	biolink:BiologicalProcess	cardiac fibroblast cell differentiation	The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac fibroblast. A cardiac fibroblast is a connective tissue cell in the heart which secretes an extracellular matrix rich in collagen and other macromolecules.		hp.json		http://purl.obolibrary.org/obo/GO_0060935		
GO:0060936	biolink:BiologicalProcess	cardiac fibroblast cell development	The process whose specific outcome is the progression of a cardiac fibroblast over time, from its formation to the mature state. A cardiac fibroblast is a connective tissue cell of the heart which secretes an extracellular matrix rich in collagen and other macromolecules.		hp.json		http://purl.obolibrary.org/obo/GO_0060936		
GO:0035911	biolink:BiologicalProcess	descending aorta morphogenesis	The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.		hp.json		http://purl.obolibrary.org/obo/GO_0035911		
GO:0035912	biolink:BiologicalProcess	dorsal aorta morphogenesis	The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.		hp.json		http://purl.obolibrary.org/obo/GO_0035912		
GO:0035914	biolink:BiologicalProcess	skeletal muscle cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.		hp.json		http://purl.obolibrary.org/obo/GO_0035914		
GO:0060920	biolink:BiologicalProcess	cardiac pacemaker cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a pacemaker cell. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.		hp.json	pacemaker cell differentiation	http://purl.obolibrary.org/obo/GO_0060920		
GO:0060921	biolink:BiologicalProcess	sinoatrial node cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a sinoatrial (SA) node cell. SA node cells are pacemaker cells that are found in the sinoatrial node.		hp.json	sinus node cell differentiation|SA node cell differentiation|SAN cell differentiation	http://purl.obolibrary.org/obo/GO_0060921		
GO:0060922	biolink:BiologicalProcess	atrioventricular node cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.		hp.json	AV node cell differentiation	http://purl.obolibrary.org/obo/GO_0060922		
GO:0060926	biolink:BiologicalProcess	cardiac pacemaker cell development	The process whose specific outcome is the progression of a pacemaker cell over time, from its formation to the mature state. Pacemaker cells are specialized cardiomyocytes that are responsible for regulating the timing of heart contractions.		hp.json	pacemaker cell development	http://purl.obolibrary.org/obo/GO_0060926		
GO:0060928	biolink:BiologicalProcess	atrioventricular node cell development	The process whose specific outcome is the progression of an atrioventricular (AV) node cell over time, from its formation to the mature state.		hp.json	AV node cell development	http://purl.obolibrary.org/obo/GO_0060928		
GO:0035909	biolink:BiologicalProcess	aorta morphogenesis	The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0035909		
HP:0030490	biolink:PhenotypicFeature	Exudative vitreoretinopathy		UMLS:C4072980	hp.json		http://purl.obolibrary.org/obo/HP_0030490		
UBERON:0003528	biolink:AnatomicalEntity	brain gray matter	A gray matter that is part of a brain [Automatically generated definition].	NCIT:C49333|UMLS:C1707348|MA:0000810|EMAPA:35184	hp.json	gray matter of brain|grey substance of brain|grey matter of brain|brain grey substance|brain grey matter	http://purl.obolibrary.org/obo/UBERON_0003528		
HP:0500112	biolink:PhenotypicFeature	Positive urine amphetamine test	Detection of amphetamine or its metabolites in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0500112		
UBERON:0003529	biolink:AnatomicalEntity	respiratory system lymphatic vessel endothelium	An lymphatic vessel endothelium that is part of a respiratory system [Automatically generated definition].	MA:0001825|EMAPA:37581	hp.json	endothelium of lymph vessel of respiratory system|apparatus respiratorius lymph vessel endothelium|apparatus respiratorius endothelium of lymph vessel|lymph vessel endothelium of apparatus respiratorius|lymphatic vessel endothelium of respiratory system|lymphatic vessel endothelium of apparatus respiratorius|respiratory system lymphatic vessel endothelium|lymph vessel endothelium of respiratory system|respiratory system endothelium of lymph vessel|respiratory system lymph vessel endothelium|endothelium of lymph vessel of apparatus respiratorius|apparatus respiratorius lymphatic vessel endothelium	http://purl.obolibrary.org/obo/UBERON_0003529		human_reference_atlas
HP:0500113	biolink:PhenotypicFeature	Positive urine opioid test	Detection of opioids or opioid metabolites in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0500113		
UBERON:0003526	biolink:AnatomicalEntity	respiratory system capillary	A capillary that is part of a respiratory system [Automatically generated definition].	EMAPA:37574|MA:0001807	hp.json	capillary vessel of respiratory system|capillary of apparatus respiratorius|respiratory system blood capillary|respiratory system capillary vessel|capillary of respiratory system|capillary vessel of apparatus respiratorius|apparatus respiratorius capillary|apparatus respiratorius capillary vessel|blood capillary of respiratory system|blood capillary of apparatus respiratorius|apparatus respiratorius blood capillary	http://purl.obolibrary.org/obo/UBERON_0003526		
HP:0500110	biolink:PhenotypicFeature	Positive urine cannabinoid test	Detection of delta-9-tetrahydrocannabinol (THC) or other cannabinoid metabolites in urine.		hp.json	Positive urine marijuana test|Postive urine pot test	http://purl.obolibrary.org/obo/HP_0500110		
HP:0500111	biolink:PhenotypicFeature	Positive urine benzodiazepines test	Detection of benzodiazepine metabolites, primarily nordiazepam, oxazepam, and temazepam, in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0500111		
UBERON:0003527	biolink:AnatomicalEntity	kidney capillary	A capillary that is part of a kidney [Automatically generated definition].	EMAPA:31443|MA:0002586	hp.json	capillary of kidney|blood capillary of kidney|capillary vessel of kidney|kidney capillary vessel|renal capillary|kidney blood capillary	http://purl.obolibrary.org/obo/UBERON_0003527		pheno_slim
HP:0500116	biolink:PhenotypicFeature	Positive blood barbiturate test	Detection of barbiturate metabolites such as Phenobarbital in blood.		hp.json		http://purl.obolibrary.org/obo/HP_0500116		
HP:0030495	biolink:PhenotypicFeature	Abnormality morphology of the macular vasculature	Any structural anomaly of the blood vessels of the macula.	UMLS:C4072983	hp.json	Abnormality of macular vasculature	http://purl.obolibrary.org/obo/HP_0030495		
HP:0030496	biolink:PhenotypicFeature	Macular exudate	Yellow-white intraretinal deposits in the macula typically associated with damaged outer blood-retina barrier and exudation of serous fluid and lipids from the retinal microvasculature.	UMLS:C4072984	hp.json	Macular exudates|Macular exudation	http://purl.obolibrary.org/obo/HP_0030496		
HP:0500117	biolink:PhenotypicFeature	Abnormal CSF urate concentration	Abnormal concentration of urate in the cerebrospinal fluid (CSF).		hp.json		http://purl.obolibrary.org/obo/HP_0500117		
HP:0500114	biolink:PhenotypicFeature	Abnormal stool urobilinogen concentration	Abnormal concentration of urobilinogen present in the stool.		hp.json		http://purl.obolibrary.org/obo/HP_0500114		
HP:0030497	biolink:PhenotypicFeature	Macular cotton wool spot	Fluffy white patch on the macula, representing localized areas of dense white swelling of the retinal nerve fibre layer. They often have a zigzag internal structure, a feathered edge but an otherwise well-delineated form and an approximately 1 mm dimension; they project slightly into the vitreous and sometimes deflect retinal vessels.	UMLS:C4072985	hp.json		http://purl.obolibrary.org/obo/HP_0030497		
HP:0500115	biolink:PhenotypicFeature	Increased stool urobilinogen concentration	An increased amount of urobilinogen present in the stool.		hp.json		http://purl.obolibrary.org/obo/HP_0500115		
HP:0030498	biolink:PhenotypicFeature	Macular thickening	Abnormal increase in retinal thickness in the macular area observed on fundoscopy or fundus imaging.	UMLS:C4072986	hp.json		http://purl.obolibrary.org/obo/HP_0030498		
GO:0035904	biolink:BiologicalProcess	aorta development	The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0035904		
HP:0030491	biolink:PhenotypicFeature	Choriocapillaris atrophy	Atrophy of the capillary lamina of choroid.	UMLS:C3275758	hp.json		http://purl.obolibrary.org/obo/HP_0030491		
GO:0035906	biolink:BiologicalProcess	descending aorta development	The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.		hp.json		http://purl.obolibrary.org/obo/GO_0035906		
HP:0030493	biolink:PhenotypicFeature	Abnormality of foveal pigmentation	An anomaly of the pigmentation in the fovea centralis.	UMLS:C4072981	hp.json		http://purl.obolibrary.org/obo/HP_0030493		
GO:0035907	biolink:BiologicalProcess	dorsal aorta development	The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.		hp.json		http://purl.obolibrary.org/obo/GO_0035907		
HP:0030494	biolink:PhenotypicFeature	Macular microaneurysm/hemorrhage	Small, red dots in the superficial retinal layers (it is difficult to distinguish between small hemorrhages and microaneurysms).	UMLS:C4072982	hp.json		http://purl.obolibrary.org/obo/HP_0030494		
GO:0060950	biolink:BiologicalProcess	cardiac glial cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0060950		
HP:0030499	biolink:PhenotypicFeature	Macular drusen	Drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in Bruch's membrane of the eye. This class refers to the presence of Drusen in the macula.	SNOMEDCT_US:247154004|UMLS:C0677628	hp.json	Lipid accumulation in macula	http://purl.obolibrary.org/obo/HP_0030499		
GO:0060952	biolink:BiologicalProcess	cardiac glial cell development	The process aimed at the progression of a cardiac glial cell over time, from its formation to the fully functional mature cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060952		
UBERON:0003535	biolink:AnatomicalEntity	vagus X nerve trunk	A nerve trunk that is part of a vagus nerve.	EHDAA2:0002160|EHDAA:4659|FMA:6221|VHOG:0000736|EMAPA:17272|MA:0001150	hp.json	trunk of vagal nerve|vagus neural trunk|vagal nerve trunk|trunk of vagus nerve|vagal X nerve trunk|vagus nerve trunk	http://purl.obolibrary.org/obo/UBERON_0003535		
GO:0060956	biolink:BiologicalProcess	endocardial cell differentiation	The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers.		hp.json		http://purl.obolibrary.org/obo/GO_0060956		
UBERON:0003533	biolink:AnatomicalEntity	manual digit skin	A zone of skin that is part of a finger [Automatically generated definition].	FMA:38304|NCIT:C52720|EMAPA:32648|UMLS:C1708318|MA:0000626	hp.json	skin of hand digit|skin of digit of hand|skin of finger|hand digit skin|hand digit skin|skin of digitus manus|skin of digit of terminal segment of free upper limb|digitus manus skin|fore limb digit skin|digit of hand skin|digit of terminal segment of free upper limb skin|finger skin|terminal segment of free upper limb digit skin|skin of terminal segment of free upper limb digit	http://purl.obolibrary.org/obo/UBERON_0003533		
UBERON:0003534	biolink:AnatomicalEntity	tail skin	A zone of skin that is part of a tail [Automatically generated definition].	MA:0000700|EMAPA:36502	hp.json	post-vent region skin|skin of post-vent region|skin of tail	http://purl.obolibrary.org/obo/UBERON_0003534		pheno_slim
GO:0060958	biolink:BiologicalProcess	endocardial cell development	The progression of an endocardial cell over time, from its formation to the mature cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0060958		
UBERON:0003531	biolink:AnatomicalEntity	forelimb skin	A zone of skin that is part of a forelimb [Automatically generated definition].	FMA:23101|UMLS:C0222212|EMAPA:32612|MA:0000617|NCIT:C12296	hp.json	skin of fore limb|upper limb skin|wing skin|fore limb skin|anteriormost limb skin|skin of upper limb|skin of forelimb	http://purl.obolibrary.org/obo/UBERON_0003531		
GO:0060959	biolink:BiologicalProcess	cardiac neuron development	The process whose specific outcome is the progression of a cardiac neuron over time, from its formation to the mature state.		hp.json	heart neuron development	http://purl.obolibrary.org/obo/GO_0060959		
UBERON:0003532	biolink:AnatomicalEntity	hindlimb skin	A zone of skin that is part of a hindlimb [Automatically generated definition].	MA:0000665|UMLS:C0222268|NCIT:C12297|EMAPA:32620|FMA:23102	hp.json	hind limb skin|skin of lower extremity|skin of hindlimb|lower limb skin|skin of lower limb|skin of hind limb	http://purl.obolibrary.org/obo/UBERON_0003532		
UBERON:0003530	biolink:AnatomicalEntity	pedal digit skin	A zone of skin that is part of a toe [Automatically generated definition].	UMLS:C1708089|MA:0000650|NCIT:C52719|EMAPA:32942|FMA:37852	hp.json	skin of foot digit|foot digit skin|skin of digitus pedis|skin of digit of foot|skin of digit of terminal segment of free lower limb|digit of foot skin|digitus pedis skin|foot digit skin|digit of terminal segment of free lower limb skin|hind limb digit skin|skin of terminal segment of free lower limb digit|skin of toe|toe skin|terminal segment of free lower limb digit skin	http://purl.obolibrary.org/obo/UBERON_0003530		
UBERON:0003519	biolink:AnatomicalEntity	thoracic cavity blood vessel	A blood vessel that is part of a thoracic cavity [Automatically generated definition].	EMAPA:37240|MA:0000554	hp.json	chest cavity blood vessel|blood vessel of cavity of thorax|cavity of thorax blood vessel|blood vessel of thoracic cavity|blood vessel of cavity of chest|blood vessel of pectoral cavity|pectoral cavity blood vessel|blood vessel of chest cavity|cavity of chest blood vessel	http://purl.obolibrary.org/obo/UBERON_0003519		
UBERON:0003517	biolink:AnatomicalEntity	kidney blood vessel	A blood vessel that is part of a kidney [Automatically generated definition].	EMAPA:28457|ZFA:0005306|TAO:0005306|MA:0001682	hp.json	renal blood vessel|blood vessel of kidney	http://purl.obolibrary.org/obo/UBERON_0003517		pheno_slim|vertebrate_core
HP:0500101	biolink:PhenotypicFeature	Gastric fluid xenobiotic	Presence of a xenobiotic in gastric fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0500101		
UBERON:0003515	biolink:AnatomicalEntity	forelimb blood vessel	A blood vessel that is part of a forelimb [Automatically generated definition].	MA:0000611|EMAPA:37292	hp.json	fore limb blood vessel|anteriormost limb blood vessel|blood vessel of forelimb|blood vessel of anteriormost limb|blood vessel of upper extremity|blood vessel of fore limb|wing blood vessel	http://purl.obolibrary.org/obo/UBERON_0003515		
UBERON:0003516	biolink:AnatomicalEntity	hindlimb blood vessel	A blood vessel that is part of a hindlimb [Automatically generated definition].	MA:0000659|EMAPA:37298	hp.json	blood vessel of hind limb|hind limb blood vessel|blood vessel of lower extremity|blood vessel of hindlimb	http://purl.obolibrary.org/obo/UBERON_0003516		
HP:0500100	biolink:PhenotypicFeature	Plasma/serum xenobiotic	Presence of a xenobiotic in plasma and/or serum.		hp.json		http://purl.obolibrary.org/obo/HP_0500100		
HP:0500105	biolink:PhenotypicFeature	Decreased systolic blood pressure	Abnormal decrease in systolic blood pressure.		hp.json	Decreased systolic BP|Reduced systolic blood pressure	http://purl.obolibrary.org/obo/HP_0500105		
HP:0500106	biolink:PhenotypicFeature	Isolated systolic hypertension	Elevated systolic blood pressure without an elevated blood pressure.		hp.json		http://purl.obolibrary.org/obo/HP_0500106		
HP:0500104	biolink:PhenotypicFeature	Decreased diastolic blood pressure	Abnormal decrease in diastolic blood pressure.		hp.json	Decreased diastolic BP|Reduced diastolic blood pressure	http://purl.obolibrary.org/obo/HP_0500104		
GO:0045321	biolink:BiologicalProcess	leukocyte activation	A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.	Wikipedia:Immunologic_activation	hp.json	immune cell activation|leucocyte activation	http://purl.obolibrary.org/obo/GO_0045321		
HP:0500109	biolink:PhenotypicFeature	Positive urine barbiturate test	Detection of barbiturate metabolites such as Phenobarbital in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0500109		
HP:0500107	biolink:PhenotypicFeature	Isolated diastolic hypotension	A decrease in diastolic blood pressure (<60 mmHg) without a decrease in systolic blood pressure (> or = to 100 mmHg).		hp.json		http://purl.obolibrary.org/obo/HP_0500107		
HP:0500108	biolink:PhenotypicFeature	Positive urine cocaine test	Detection of cocaine or its major metabolite, benzoylecgonine, in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0500108		
UBERON:0003524	biolink:AnatomicalEntity	tail blood vessel	A blood vessel that is part of a tail [Automatically generated definition].	MA:0000695|EMAPA:35848	hp.json	post-vent region blood vessel|blood vessel of post-vent region|blood vessel of tail	http://purl.obolibrary.org/obo/UBERON_0003524		
GO:0060945	biolink:BiologicalProcess	cardiac neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron of the heart.		hp.json	heart neuron differentiation	http://purl.obolibrary.org/obo/GO_0060945		
UBERON:0003522	biolink:AnatomicalEntity	manual digit blood vessel	A blood vessel that is part of a finger [Automatically generated definition].	EMAPA:37297|MA:0000621	hp.json	blood vessel of terminal segment of free upper limb digit|finger blood vessel|terminal segment of free upper limb digit blood vessel|hand digit blood vessel|hand digit blood vessel|blood vessel of digit of terminal segment of free upper limb|digit of terminal segment of free upper limb blood vessel	http://purl.obolibrary.org/obo/UBERON_0003522		
GO:0060946	biolink:BiologicalProcess	cardiac blood vessel endothelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell of the heart. Blood vessel endothelial cells are thin flattened cells that line the inside surfaces of blood vessels.		hp.json		http://purl.obolibrary.org/obo/GO_0060946		
UBERON:0003523	biolink:AnatomicalEntity	manus blood vessel	A blood vessel that is part of a manus [Automatically generated definition].	EMAPA:37296|MA:0000618	hp.json	blood vessel of hand|blood vessel of manus|hand blood vessel	http://purl.obolibrary.org/obo/UBERON_0003523		
UBERON:0003520	biolink:AnatomicalEntity	pelvis blood vessel	A blood vessel that is part of a pelvis [Automatically generated definition].	MA:0000531|EMAPA:37244	hp.json	blood vessel of pelvis	http://purl.obolibrary.org/obo/UBERON_0003520		
UBERON:0003521	biolink:AnatomicalEntity	pes blood vessel	A blood vessel that is part of a foot [Automatically generated definition].	MA:0000642|EMAPA:37301	hp.json	blood vessel of foot|foot blood vessel	http://purl.obolibrary.org/obo/UBERON_0003521		
UBERON:0003508	biolink:AnatomicalEntity	pedal digit blood vessel	A blood vessel that is part of a toe [Automatically generated definition].	EMAPA:37302|MA:0000645	hp.json	digitus pedis blood vessel|digit of foot blood vessel|blood vessel of toe|blood vessel of terminal segment of free lower limb digit|digit of terminal segment of free lower limb blood vessel|hind limb digit blood vessel|terminal segment of free lower limb digit blood vessel|toe blood vessel|foot digit blood vessel|blood vessel of foot digit|blood vessel of digit of foot|blood vessel of digitus pedis|foot digit blood vessel|blood vessel of digit of terminal segment of free lower limb	http://purl.obolibrary.org/obo/UBERON_0003508		
UBERON:0003509	biolink:AnatomicalEntity	arterial blood vessel	A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta.	MA:0000061|EMAPA:35144	hp.json		http://purl.obolibrary.org/obo/UBERON_0003509		pheno_slim
UBERON:0003506	biolink:AnatomicalEntity	chest blood vessel	A blood vessel that is part of a chest [Automatically generated definition].	MA:0000549|EMAPA:37239	hp.json	anterior thoracic region blood vessel|blood vessel of anterolateral part of thorax|blood vessel of anterior thoracic region|anterolateral part of thorax blood vessel|blood vessel of chest|front of thorax blood vessel|blood vessel of front of thorax	http://purl.obolibrary.org/obo/UBERON_0003506		
UBERON:0003507	biolink:AnatomicalEntity	arm blood vessel	A blood vessel that is part of an arm [Automatically generated definition].	MA:0000591|EMAPA:37293	hp.json	blood vessel of arm	http://purl.obolibrary.org/obo/UBERON_0003507		
UBERON:0003504	biolink:AnatomicalEntity	respiratory system blood vessel	A blood vessel that is part of a respiratory system [Automatically generated definition].	EMAPA:35995|EMAPA:35731|MA:0001799	hp.json	blood vessel of apparatus respiratorius|apparatus respiratorius blood vessel|blood vessel of respiratory system	http://purl.obolibrary.org/obo/UBERON_0003504		
UBERON:0003505	biolink:AnatomicalEntity	trachea blood vessel	A blood vessel that is part of a trachea.	EMAPA:35874|MA:0001852	hp.json	blood vessel of trachea	http://purl.obolibrary.org/obo/UBERON_0003505		human_reference_atlas
GO:0060973	biolink:BiologicalProcess	cell migration involved in heart development	The orderly movement of a cell from one site to another that will contribute to the progression of the heart over time, from its initial formation, to the mature organ.		hp.json		http://purl.obolibrary.org/obo/GO_0060973		
GO:0060974	biolink:BiologicalProcess	cell migration involved in heart formation	The orderly movement of a cell from one site to another that contribute to the formation of the heart. The initial heart structure is made up of mesoderm-derived heart progenitor cells and neural crest-derived cells.		hp.json		http://purl.obolibrary.org/obo/GO_0060974		
GO:0060976	biolink:BiologicalProcess	coronary vasculature development	The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.		hp.json	coronary blood vessel development|heart vasculature development|heart blood vessel development|cardiac blood vessel development|cardiac vasculature development	http://purl.obolibrary.org/obo/GO_0060976		
UBERON:0003513	biolink:AnatomicalEntity	trunk blood vessel	A blood vessel that is part of a trunk [Automatically generated definition].	MA:0000511|EMAPA:37237	hp.json	blood vessel of trunk|blood vessel of torso|torso blood vessel	http://purl.obolibrary.org/obo/UBERON_0003513		
GO:0060977	biolink:BiologicalProcess	coronary vasculature morphogenesis	The process in which the anatomical structures of blood vessels of the heart are generated and organized. The blood vessel is the vasculature carrying blood.		hp.json	cardiac blood vessel morphogenesis|cardiac vasculature morphogenesis|heart vasculature morphogenesis|coronary blood vessel morphogenesis|heart blood vessel morphogenesis	http://purl.obolibrary.org/obo/GO_0060977		
GO:0060978	biolink:BiologicalProcess	angiogenesis involved in coronary vascular morphogenesis	Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels.		hp.json	angiogenesis involved in cardiac vascular morphogenesis|coronary vasculature angiogenesis|coronary blood vessel angiogenesis|angiogenesis involved in heart vascular morphogenesis	http://purl.obolibrary.org/obo/GO_0060978		
UBERON:0003514	biolink:AnatomicalEntity	limb blood vessel	A blood vessel that is part of a limb [Automatically generated definition].	EMAPA:36598|MA:0000687	hp.json	blood vessel of limb	http://purl.obolibrary.org/obo/UBERON_0003514		
UBERON:0003511	biolink:AnatomicalEntity	iris blood vessel	A blood vessel that is part of a iris [Automatically generated definition].	EMAPA:37387|MA:0001290|ZFA:0005568	hp.json	blood vessel of iris	http://purl.obolibrary.org/obo/UBERON_0003511		vertebrate_core
GO:0060979	biolink:BiologicalProcess	vasculogenesis involved in coronary vascular morphogenesis	The differentiation of endothelial cells from progenitor cells that contributes to blood vessel development in the heart, and the de novo formation of blood vessels and tubes.		hp.json	vasculogenesis involved in coronary blood vessel morphogenesis|coronary vasculogenesis	http://purl.obolibrary.org/obo/GO_0060979		
UBERON:0003512	biolink:AnatomicalEntity	lung blood vessel	A blood vessel that is part of a lung [Automatically generated definition].	MA:0002457|EMAPA:32867	hp.json	pulmonary vascular element|blood vessel of lung	http://purl.obolibrary.org/obo/UBERON_0003512		pheno_slim
UBERON:0003510	biolink:AnatomicalEntity	eyelid blood vessel	A blood vessel that is part of a eyelid [Automatically generated definition].	EMAPA:37388|MA:0001250	hp.json	blood vessel of blepharon|blood vessel of eyelid|blepharon blood vessel	http://purl.obolibrary.org/obo/UBERON_0003510		
UBERON:0003502	biolink:AnatomicalEntity	neck blood vessel	A blood vessel that is part of a neck [Automatically generated definition].	MA:0000583|EMAPA:37236	hp.json	blood vessel of neck|neck (volume) blood vessel|blood vessel of neck (volume)	http://purl.obolibrary.org/obo/UBERON_0003502		
UBERON:0003503	biolink:AnatomicalEntity	leg blood vessel	A blood vessel that is part of a leg [Automatically generated definition].	MA:0000669|EMAPA:36500	hp.json	blood vessel of leg	http://purl.obolibrary.org/obo/UBERON_0003503		
UBERON:0003500	biolink:AnatomicalEntity	corneal blood vessel	A blood vessel that is part of a cornea [Automatically generated definition].	EMAPA:36611|MA:0001241	hp.json	blood vessel of cornea|cornea blood vessel	http://purl.obolibrary.org/obo/UBERON_0003500		
UBERON:0003501	biolink:AnatomicalEntity	retina blood vessel	A blood vessel that is part of a retina [Automatically generated definition].	SCTID:280692003|MA:0001317|MESH:D012171|EMAPA:36520|GAID:509|XAO:0004153	hp.json	blood vessel of inner layer of eyeball|blood vessel of retina|tunica interna of eyeball blood vessel|inner layer of eyeball blood vessel|retinal blood vessel|blood vessel of tunica interna of eyeball	http://purl.obolibrary.org/obo/UBERON_0003501		pheno_slim
HP:0005490	biolink:PhenotypicFeature	Postnatal macrocephaly	The postnatal development of an abnormally large skull (macrocephaly).	UMLS:C1854417	hp.json	Macrocephaly, postnatal	http://purl.obolibrary.org/obo/HP_0005490		
HP:0030451	biolink:PhenotypicFeature	Mesenteric cyst	A closed fluid filled sac originating from the mesentary.	SNOMEDCT_US:253802003|MSH:D008639|SNOMEDCT_US:27970007|UMLS:C0025467	hp.json		http://purl.obolibrary.org/obo/HP_0030451		
HP:0030452	biolink:PhenotypicFeature	Chylolymphatic mesenteric cyst	A type of mesenteric cyst that is lined with a thin endothelium or mesothelium and filled with chylous and lymphatic fluid.	UMLS:C4072944	hp.json		http://purl.obolibrary.org/obo/HP_0030452		
HP:0030453	biolink:PhenotypicFeature	Abnormal visual electrophysiology		UMLS:C4072945	hp.json		http://purl.obolibrary.org/obo/HP_0030453		
HP:0030454	biolink:PhenotypicFeature	Abnormal electrooculogram	The clinical electro-oculogram (EOG) is an electrophysiological test of function of the outer retina and retinal pigment epithelium (RPE) in which changes in electrical potential across the RPE are recorded during successive periods of dark and light adaptation.	UMLS:C0159104|SNOMEDCT_US:442770004	hp.json	Abnormal EOG	http://purl.obolibrary.org/obo/HP_0030454		
HP:0030450	biolink:PhenotypicFeature	Neoplasm of the autonomic nervous system	A tumor that arises from an element of the autonomic nervous system.	NCIT:C5112|UMLS:C4072943	hp.json		http://purl.obolibrary.org/obo/HP_0030450		
HP:0030455	biolink:PhenotypicFeature	Abnormality of pattern visual evoked potentials		UMLS:C4072946	hp.json		http://purl.obolibrary.org/obo/HP_0030455		
HP:0030456	biolink:PhenotypicFeature	Abnormality of pattern onset/offset visual evoked potentials		UMLS:C4072947	hp.json	Abnormality of pattern onset/offset VEP	http://purl.obolibrary.org/obo/HP_0030456		
HP:0030457	biolink:PhenotypicFeature	Abnormal amplitude of pattern onset/offset visual evoked potentials		UMLS:C4072948	hp.json	Abnormal amplitude of pattern onset/offset VEP	http://purl.obolibrary.org/obo/HP_0030457		
HP:0030458	biolink:PhenotypicFeature	Abnormal timing of pattern onset/offset visual evoked potentials		UMLS:C4072949	hp.json		http://purl.obolibrary.org/obo/HP_0030458		
HP:0005484	biolink:PhenotypicFeature	Secondary microcephaly	Head circumference which falls below 2 standard deviations below the mean for age and gender because of insufficient head growth after birth.	UMLS:C1847514	hp.json	Deceleration of head growth|Development of small head that was not present at birth|Postnatal deceleration of head circumference|Acquired microcephaly|Microcephaly, postnatal|Postnatal microcephaly|Microcephaly, acquired	http://purl.obolibrary.org/obo/HP_0005484		
HP:0005486	biolink:PhenotypicFeature	Small fontanelle	A fontanelle that is small for age.	UMLS:C4072855|UMLS:C4072854|SNOMEDCT_US:276710001|UMLS:C0456133	hp.json	Little fontanelle|Small bregma sutures|Microfontanelle|Small cranial sutures|Little cranial sutures|Small soft spot	http://purl.obolibrary.org/obo/HP_0005486		hposlim_core
HP:0005487	biolink:PhenotypicFeature	Prominent metopic ridge	Vertical bony ridge positioned in the midline of the forehead.	UMLS:C1857949	hp.json	Ridging of metopic suture|Prominent frontal ridge|Prominent frontal suture|Prominent metopic suture|Ridging of frontal suture	http://purl.obolibrary.org/obo/HP_0005487		hposlim_core
GO:0033366	biolink:BiologicalProcess	protein localization to secretory granule	A process in which a protein is transported to, or maintained in, a location within a secretory granule.		hp.json	protein localisation in secretory granule|protein localization in secretory granule	http://purl.obolibrary.org/obo/GO_0033366		
GO:0033365	biolink:BiologicalProcess	protein localization to organelle	A process in which a protein is transported to, or maintained in, a location within an organelle.		hp.json	protein localization in organelle|protein localisation to organelle	http://purl.obolibrary.org/obo/GO_0033365		
HP:0005482	biolink:PhenotypicFeature	Abnormality of the alternative complement pathway	A deviation in any aspect of the alternative complement pathway.	UMLS:C4025191	hp.json		http://purl.obolibrary.org/obo/HP_0005482		
GO:0033363	biolink:BiologicalProcess	secretory granule organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.		hp.json	secretory granule organization and biogenesis|secretory granule organisation	http://purl.obolibrary.org/obo/GO_0033363		
HP:0005483	biolink:PhenotypicFeature	Abnormal epiglottis morphology	An abnormality of the epiglottis.	UMLS:C4025190	hp.json	Abnormality of the epiglottis	http://purl.obolibrary.org/obo/HP_0005483		
HP:0030462	biolink:PhenotypicFeature	Abnormal amplitude of flash visual evoked potentials		UMLS:C4072952	hp.json		http://purl.obolibrary.org/obo/HP_0030462		
HP:0030463	biolink:PhenotypicFeature	Asymmetrical distribution of flash visual evoked potentials		UMLS:C4072953	hp.json	Crossed asymmetry of flash visual evoked potentials	http://purl.obolibrary.org/obo/HP_0030463		
HP:0030464	biolink:PhenotypicFeature	Asymmetrical distribution of pattern reversal visual evoked potentials		UMLS:C4072954	hp.json	Crossed asymmetry of pattern reversal visual evoked potentials	http://purl.obolibrary.org/obo/HP_0030464		
HP:0030465	biolink:PhenotypicFeature	Undetectable light-adapted electroretinogram	No detectable response to the light-adapted 3.0 ERG (single-flash cone response). This type of ERG measures responses of the cone system; a-waves arise from cone photoreceptors and cone off-bipolar cells; the b-wave comes from On- and Off-cone bipolar cells.	UMLS:C4072955	hp.json	Absent photopic (cone) responses on ERG|non-detectable photopic ERG	http://purl.obolibrary.org/obo/HP_0030465		
HP:0030460	biolink:PhenotypicFeature	Abnormal timing of pattern reversal visual evoked potentials		UMLS:C4072950	hp.json		http://purl.obolibrary.org/obo/HP_0030460		
HP:0030461	biolink:PhenotypicFeature	Abnormal timing of flash visual evoked potentials		UMLS:C4072951	hp.json		http://purl.obolibrary.org/obo/HP_0030461		
HP:0030466	biolink:PhenotypicFeature	Abnormal full-field electroretinogram		UMLS:C4072956	hp.json		http://purl.obolibrary.org/obo/HP_0030466		
HP:0030467	biolink:PhenotypicFeature	Abnormal pattern electroretinogram	An anomalous response to a pattern electroretinogram (PERG), a particular kind of ERG obtained in response to contrast modulation of patterned visual stimuli at constant mean luminance-typically contrast-reversing gratings or checkerboards-whose characteristics are fundamentally different from those of the traditional ERG in response to diffuse flashes of light.	UMLS:C4072957	hp.json		http://purl.obolibrary.org/obo/HP_0030467		
HP:0030468	biolink:PhenotypicFeature	Abnormal multifocal electroretinogram		UMLS:C4072958	hp.json		http://purl.obolibrary.org/obo/HP_0030468		
HP:0030469	biolink:PhenotypicFeature	Abnormal dark-adapted electroretinogram		UMLS:C4072959	hp.json		http://purl.obolibrary.org/obo/HP_0030469		
HP:0005495	biolink:PhenotypicFeature	Metopic suture patent to nasal root	The frontal suture divides the two halves of the frontal bone in infants and usually fuses by the age of six years. The suture runs from the bregma (the point on the skull at which the coronal suture is intersected perpendicularly by the sagittal suture) to the nasion or nasal root. This term applies if the suture is widely patent from bregma to nasal root.	UMLS:C4025189	hp.json		http://purl.obolibrary.org/obo/HP_0005495		
HP:0005498	biolink:PhenotypicFeature	Midline skin dimples over anterior/posterior fontanelles		UMLS:C1855690	hp.json		http://purl.obolibrary.org/obo/HP_0005498		
HP:0005494	biolink:PhenotypicFeature	Premature posterior fontanelle closure		UMLS:C1839126	hp.json		http://purl.obolibrary.org/obo/HP_0005494		
HP:0030473	biolink:PhenotypicFeature	Abnormal light-adapted flicker electroretinogram		UMLS:C4072963	hp.json	Abnormal light adapted flicker electroretinogram|Abnormal light-adapted 30Hz flicker electroretinogram|Abnormal light-adapted flicker ERG|Abnormal light-adapted 30Hz flicker ERG	http://purl.obolibrary.org/obo/HP_0030473		
HP:0030474	biolink:PhenotypicFeature	Undetectable dark-adapted electroretinogram		UMLS:C4072964	hp.json		http://purl.obolibrary.org/obo/HP_0030474		
HP:0030475	biolink:PhenotypicFeature	Abnormal timing of dark-adapted dim flash electroretinogram		UMLS:C4072965	hp.json		http://purl.obolibrary.org/obo/HP_0030475		
HP:0030476	biolink:PhenotypicFeature	Abnormal amplitude of dark-adapted dim flash electroretinogram		UMLS:C4072966	hp.json		http://purl.obolibrary.org/obo/HP_0030476		
HP:0030470	biolink:PhenotypicFeature	Abnormal dark-adapted bright flash electroretinogram		UMLS:C4072960	hp.json		http://purl.obolibrary.org/obo/HP_0030470		
HP:0030471	biolink:PhenotypicFeature	Abnormal dark-adapted dim flash electroretinogram		UMLS:C4072961	hp.json		http://purl.obolibrary.org/obo/HP_0030471		
HP:0030472	biolink:PhenotypicFeature	Abnormal light-adapted single flash electroretinogram		UMLS:C4072962	hp.json		http://purl.obolibrary.org/obo/HP_0030472		
HP:0005466	biolink:PhenotypicFeature	Hypoplasia of the frontal bone	Underdevelopment of the frontal bone.	UMLS:C4280484|UMLS:C4280483|UMLS:C1845147	hp.json	Decreased size of bone of forehead|Thin bone of forehead|Hypoplastic frontal bones|Hypotrophic frontal bone|Underdevelopment of bone of forehead|Hypotrophic frontal bones|Small bone of forehead	http://purl.obolibrary.org/obo/HP_0005466		
HP:0030477	biolink:PhenotypicFeature	Abnormal timing of dark-adapted bright flash electroretinogram		UMLS:C4072967	hp.json		http://purl.obolibrary.org/obo/HP_0030477		
HP:0030478	biolink:PhenotypicFeature	Abnormal amplitude of dark-adapted bright flash electroretinogram		UMLS:C4072968	hp.json		http://purl.obolibrary.org/obo/HP_0030478		
HP:0030479	biolink:PhenotypicFeature	Abnormal amplitude of light-adapted flicker electroretinogram		UMLS:C4072969	hp.json		http://purl.obolibrary.org/obo/HP_0030479		
HP:0005469	biolink:PhenotypicFeature	Flat occiput	Reduced convexity of the occiput (posterior part of skull).	UMLS:C1837402|UMLS:C4280482	hp.json	Posterior flattening of the skull|Flat posterior head|Flat back of the skull|Flat back of the head|Flat back of skull|Flat posterior cranium	http://purl.obolibrary.org/obo/HP_0005469		hposlim_core
HP:0005462	biolink:PhenotypicFeature	Calcification of falx cerebri	The presence of calcium deposition in the falx cerebri.	UMLS:C1397139	hp.json		http://purl.obolibrary.org/obo/HP_0005462		
HP:0005463	biolink:PhenotypicFeature	Elongated sella turcica		UMLS:C1863311	hp.json		http://purl.obolibrary.org/obo/HP_0005463		
HP:0005464	biolink:PhenotypicFeature	Craniofacial osteosclerosis	Abnormally increased density of craniofacial bone tissue.	UMLS:C1845805|UMLS:C4025193	hp.json	Cranial sclerosis	http://purl.obolibrary.org/obo/HP_0005464		
HP:0005465	biolink:PhenotypicFeature	Facial hyperostosis	Excessive growth (overgrowth) of the facial bones, that is of the facial skeleton.	UMLS:C1857501|UMLS:C4280487|UMLS:C4280486|UMLS:C4280485	hp.json	Enlargement of facial bones|Hyperostosis of facial bones|Increased ossification of facial skeleton|Hyperostosis of facial skeleton|Excessive growth of facial bones|Hypertrophy of facial bones|Enlargment of the facial bones|Excessive growth of facial skeleton|Hypertrophy of facial skeleton|Increase in size of the facial bones|Hypertrophy of the facial bones|Overgrowth of facial bones|Overgrowth of the facial bones|Increased ossification of facial bones|Enlargement of facial skeleton|Overgrowth of facial skeleton	http://purl.obolibrary.org/obo/HP_0005465		hposlim_core
GO:0033343	biolink:BiologicalProcess	positive regulation of collagen binding	Any process that activates or increases the frequency, rate or extent of collagen binding.		hp.json	activation of collagen binding|upregulation of collagen binding|up regulation of collagen binding|stimulation of collagen binding|up-regulation of collagen binding	http://purl.obolibrary.org/obo/GO_0033343		
GO:0033342	biolink:BiologicalProcess	negative regulation of collagen binding	Any process that stops, prevents, or reduces the frequency, rate or extent of collagen binding.		hp.json	down regulation of collagen binding|inhibition of collagen binding|down-regulation of collagen binding|downregulation of collagen binding	http://purl.obolibrary.org/obo/GO_0033342		
GO:0033341	biolink:BiologicalProcess	regulation of collagen binding	Any process that modulates the frequency, rate or extent of collagen binding.		hp.json		http://purl.obolibrary.org/obo/GO_0033341		
HP:0005461	biolink:PhenotypicFeature	Craniofacial disproportion		UMLS:C1867114	hp.json		http://purl.obolibrary.org/obo/HP_0005461		
HP:0030484	biolink:PhenotypicFeature	Supernormal dark-adapted bright flash electroretinogram b-wave		UMLS:C4072974	hp.json		http://purl.obolibrary.org/obo/HP_0030484		
HP:0030485	biolink:PhenotypicFeature	Abnormal amplitude of pattern electroretinogram		UMLS:C4072975	hp.json		http://purl.obolibrary.org/obo/HP_0030485		
HP:0030486	biolink:PhenotypicFeature	Abnormal timing of pattern electroretinogram		UMLS:C4072976	hp.json		http://purl.obolibrary.org/obo/HP_0030486		
HP:0030487	biolink:PhenotypicFeature	Abnormal P50/N95 ratio of pattern electroretinogram		UMLS:C4072977	hp.json		http://purl.obolibrary.org/obo/HP_0030487		
HP:0030480	biolink:PhenotypicFeature	Abnormal timing of light-adapted flicker electroretinogram		UMLS:C4072970	hp.json		http://purl.obolibrary.org/obo/HP_0030480		
HP:0030481	biolink:PhenotypicFeature	Abnormal amplitude of light-adapted single flash electroretinogram		UMLS:C4072971	hp.json		http://purl.obolibrary.org/obo/HP_0030481		
HP:0030482	biolink:PhenotypicFeature	Abnormal timing of light-adapted single flash electroretinogram		UMLS:C4072972	hp.json		http://purl.obolibrary.org/obo/HP_0030482		
HP:0030483	biolink:PhenotypicFeature	Reduced amplitude of dark-adapted bright flash electroretinogram a-wave	An abnormal reduction in the amplitude of the a-wave.	UMLS:C4072973	hp.json		http://purl.obolibrary.org/obo/HP_0030483		
GO:0035992	biolink:BiologicalProcess	tendon formation	The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.		hp.json		http://purl.obolibrary.org/obo/GO_0035992		
HP:0030488	biolink:PhenotypicFeature	Abnormal central response of multifocal electroretinogram		UMLS:C4072978	hp.json		http://purl.obolibrary.org/obo/HP_0030488		
HP:0005477	biolink:PhenotypicFeature	Progressive sclerosis of skull base	Progressively increasing bone density of the skull base without significant changes in bony contour.	UMLS:C1835470	hp.json		http://purl.obolibrary.org/obo/HP_0005477		
HP:0005478	biolink:PhenotypicFeature	Prominent frontal sinuses		UMLS:C4280481|UMLS:C4280480|UMLS:C4280479|UMLS:C1969404|UMLS:C4280265	hp.json	Large frontal sinus|Increased volume of frontal sinus|Hypertrophy of frontal sinus|Increased size of frontal sinus|Hyperplasia of frontal sinus	http://purl.obolibrary.org/obo/HP_0005478		
HP:0030489	biolink:PhenotypicFeature	Abnormal paracentral response of multifocal electroretinogram		UMLS:C4072979	hp.json		http://purl.obolibrary.org/obo/HP_0030489		
HP:0005479	biolink:PhenotypicFeature	Decreased circulating IgE	An abnormally decreased level of immunoglobulin E (IgE) in blood.	UMLS:C0860904	hp.json	IgE deficiency|Decreased IgE	http://purl.obolibrary.org/obo/HP_0005479		
HGNC:6081	biolink:Gene	INS (human)	A protein coding gene INS in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6081		
HP:0005473	biolink:PhenotypicFeature	Fusion of middle ear ossicles	Bony fusion of malleus, incus, and stapes.	UMLS:C1862068	hp.json		http://purl.obolibrary.org/obo/HP_0005473		
HP:0005474	biolink:PhenotypicFeature	Decreased calvarial ossification	Abnormal reduction in ossification of the calvaria (roof of the skull consisting of the frontal bone, parietal bones, temporal bones, and occipital bone).	UMLS:C1833762	hp.json	Skull soft on palpation|Undermineralized calvarium|Soft calvaria|Poorly ossified calvarium|Poorly ossified calvaria|Soft skullcap	http://purl.obolibrary.org/obo/HP_0005474		
HP:0005476	biolink:PhenotypicFeature	Widely patent sagittal suture	The presence of a sagittal suture (the cranial suture that separates the left and right parietal bones) that is not ossified but rather wide open at an age when it is normally closed.	UMLS:C1856779	hp.json		http://purl.obolibrary.org/obo/HP_0005476		
HP:0005472	biolink:PhenotypicFeature	Orbital craniosynostosis		UMLS:C4025192	hp.json		http://purl.obolibrary.org/obo/HP_0005472		
OBO:MAXO_0000141	biolink:NamedThing	pap smear examination	A biospecimen collection and staining procedure in which secretions and superficial cells of the cervix are collected and stained with the Papanicolaou stain followed by microscopic examination to identify the presence of abnormal cells.		hp.json	cervical cancer screening|cervical smear procedure|Papanicolaou smear procedure|pap testing	http://purl.obolibrary.org/obo/MAXO_0000141		
OBO:MAXO_0000142	biolink:NamedThing	sputum cytology examination	A diagnostic technique for lung cancer detection.  Looks for abnormal cell cytology in sputum.	NCIT:C16192	hp.json	sputum cytology testing|sputum smear examination|sputum smear testing	http://purl.obolibrary.org/obo/MAXO_0000142		
OBO:MAXO_0000140	biolink:NamedThing	clinical cytological testing	A  procedure to examine and define cellular anatomy or function. The test results are often used by a clinician to diagnose disease or disordered function.	NCIT:C49132	hp.json	clinical cytological procedure|diagnostic cytological procedure	http://purl.obolibrary.org/obo/MAXO_0000140		
OBO:MAXO_0000146	biolink:NamedThing	clinical cell count	A procedure to determine the number of cells in a clinical sample.	NCIT:C48938	hp.json	clinical pathology cell count|cell count	http://purl.obolibrary.org/obo/MAXO_0000146		
OBO:MAXO_0000143	biolink:NamedThing	urine cytology examination	Examination of the cells in urine.		hp.json	urine cytology testing	http://purl.obolibrary.org/obo/MAXO_0000143		
OBO:MAXO_0000144	biolink:NamedThing	histological procedure	Technique or procedure used for the study of the microanatomy of tissues and their cellular structure; usually involves microscopic examination of tissue slices.	NCIT:C16680	hp.json	histological testing	http://purl.obolibrary.org/obo/MAXO_0000144		
GO:0035989	biolink:BiologicalProcess	tendon development	The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.		hp.json	sinew development	http://purl.obolibrary.org/obo/GO_0035989		
GO:0008366	biolink:BiologicalProcess	axon ensheathment	Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.		hp.json	nerve ensheathment|cellular nerve ensheathment|cellular axon ensheathment	http://purl.obolibrary.org/obo/GO_0008366		
HP:0030410	biolink:PhenotypicFeature	Sebaceous gland carcinoma	A carcinoma that arises in a sebaseous gland (an exocrine gland of the skin that secretes sebum, a waxy substance)	MSH:D018266|SNOMEDCT_US:54734006|UMLS:C0206684|SNOMEDCT_US:307599002	hp.json	Sebaceous carcinoma	http://purl.obolibrary.org/obo/HP_0030410		
HP:0030415	biolink:PhenotypicFeature	Sarcomatoid carcinoma of the tongue	Sarcomatoid (spindle cell) carcinomas of the tongue is a variant of squamous carcinoma of tongue that is monoclonal, having evolved from a conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation.	UMLS:C2018408	hp.json	Spindle cell carcinoma of the tongue	http://purl.obolibrary.org/obo/HP_0030415		
GO:0035981	biolink:BiologicalProcess	tongue muscle cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell.		hp.json		http://purl.obolibrary.org/obo/GO_0035981		
HP:0030416	biolink:PhenotypicFeature	Vulvar neoplasm	A tumor (abnormal growth of tissue) of the female external genital tract (vulva).	UMLS:C0042995|SNOMEDCT_US:126922007|NCIT:C3262|MSH:D014846	hp.json	Tumour of the vulva|Neoplasm of the vulva|Tumor of the vulva	http://purl.obolibrary.org/obo/HP_0030416		
HP:0030417	biolink:PhenotypicFeature	Squamous cell carcinoma of the vulva	A cancer that originates in the squamous cells that line the surface of the vulva.	SNOMEDCT_US:254895003|UMLS:C0280856	hp.json	Vulval squamous cell carcinoma	http://purl.obolibrary.org/obo/HP_0030417		
HP:0030418	biolink:PhenotypicFeature	Vulvar melanoma	A type of vulvar cancer that originates from melanocytes of the vulva.	SNOMEDCT_US:254896002|UMLS:C0241989	hp.json		http://purl.obolibrary.org/obo/HP_0030418		
HP:0030411	biolink:PhenotypicFeature	Jejunal adenocarcinoma	A malignant epithelial tumor with a glandular organization that originates in the jejunum.	UMLS:C4072935|NCIT:C2852	hp.json		http://purl.obolibrary.org/obo/HP_0030411		
HP:0030412	biolink:PhenotypicFeature	Ileal adenocarcinoma	A malignant epithelial tumor with a glandular organization that originates in the ileum.	UMLS:C4072936|NCIT:C2852	hp.json		http://purl.obolibrary.org/obo/HP_0030412		
HP:0030413	biolink:PhenotypicFeature	Squamous cell carcinoma of the tongue	A carcinoma derived from a squamous epithelial cell of the tongue.	SNOMEDCT_US:276952000|UMLS:C0349566	hp.json		http://purl.obolibrary.org/obo/HP_0030413		
HP:0030414	biolink:PhenotypicFeature	Verrucous cell carcinoma of the tongue	A low-grade variant of squamous cell carcinoma of the tongue with a warty (verrucous) appearance.	UMLS:C4072937	hp.json		http://purl.obolibrary.org/obo/HP_0030414		
GO:0035987	biolink:BiologicalProcess	endodermal cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.		hp.json	endoderm cell differentiation	http://purl.obolibrary.org/obo/GO_0035987		
OBO:MAXO_0000149	biolink:NamedThing	hematocrit assessment	A measure of the volume of red blood cells expressed as a percentage of the total blood volume. Normal in males is 43-49%, in females 37-43%.	NCIT:C64796	hp.json	HCT|hematocrit testing|hematocrit measurement|EVF testing|packed cell volume measurement|erythrocyte volume fraction testing|PCV measurement	http://purl.obolibrary.org/obo/MAXO_0000149		
OBO:MAXO_0000147	biolink:NamedThing	hematology testing	A procedure to measure hematopoietic components and investigate hematologic disorders in a blood sample.	NCIT:C49286	hp.json	hematology procedure|blood testing	http://purl.obolibrary.org/obo/MAXO_0000147		
OBO:MAXO_0000148	biolink:NamedThing	oxygen capacity assessment	The determination of the maximum amount of oxygen that can be combined chemically with hemoglobin in a volume of blood.	NCIT:C96614	hp.json	oxygen capacity measurement|OXYCAP testing|oxygen capacity testing	http://purl.obolibrary.org/obo/MAXO_0000148		
HP:0030419	biolink:PhenotypicFeature	Bartholin gland carcinoma	A cancer arising in a cell of the Bartholin gland, a racemose gland located slightly posterior to the opening of the vagina.	UMLS:C0349561|SNOMEDCT_US:399533005|SNOMEDCT_US:276876007	hp.json		http://purl.obolibrary.org/obo/HP_0030419		
HP:0030420	biolink:PhenotypicFeature	Vulvar adenocarcinoma	An adenocarcinoma arising in the vulva.	UMLS:C1336975	hp.json		http://purl.obolibrary.org/obo/HP_0030420		
HP:0030421	biolink:PhenotypicFeature	Epididymal neoplasm	A tumor (abnormal growth of tissue) of the epididymis, an duct that transports spermatozoa from the testis to the vas deferens.	SNOMEDCT_US:126902008|UMLS:C0346239|NCIT:C3262	hp.json		http://purl.obolibrary.org/obo/HP_0030421		
GO:0008374	biolink:MolecularActivity	O-acyltransferase activity	Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.	Reactome:R-HSA-1482781|Reactome:R-HSA-162683|Reactome:R-HSA-422104|Reactome:R-HSA-422017|Reactome:R-HSA-1482861|Reactome:R-HSA-1482867|Reactome:R-HSA-5358343|Reactome:R-HSA-1482775|Reactome:R-HSA-5483229|Reactome:R-HSA-1482850|Reactome:R-HSA-3238694	hp.json		http://purl.obolibrary.org/obo/GO_0008374		
HP:0030426	biolink:PhenotypicFeature	Ossifying fibroma	A benign central bone tumor composed of fibrous connective tissue within which bone is formed.	SNOMEDCT_US:302862001|MSH:D018214|SNOMEDCT_US:25603007|UMLS:C0206640|SNOMEDCT_US:80699009|SNOMEDCT_US:302863006	hp.json		http://purl.obolibrary.org/obo/HP_0030426		
HP:0030427	biolink:PhenotypicFeature	Ossifying fibroma of the jaw	A benign central bone tumor of the jaw composed of fibrous connective tissue within which bone is formed.	UMLS:C4072940	hp.json		http://purl.obolibrary.org/obo/HP_0030427		
HP:0030428	biolink:PhenotypicFeature	Cutaneous myxoma	A myxoma originating in the skin.	UMLS:C1333178|NCIT:C6577	hp.json		http://purl.obolibrary.org/obo/HP_0030428		
HP:0030429	biolink:PhenotypicFeature	Juvenile nasopharyngeal angiofibroma	A benign but highly vascular nasopharyngeal neoplasm. The tumor originates from the sphenopalatine foramen and involves both the pterygopalatine fossa and the posterior nasal cavity.	SNOMEDCT_US:716590006|UMLS:C1367536|SNOMEDCT_US:60392001	hp.json		http://purl.obolibrary.org/obo/HP_0030429		
HP:0030422	biolink:PhenotypicFeature	obsolete Papillary cystadenoma of the epididymis			hp.json		http://purl.obolibrary.org/obo/HP_0030422		
HP:0030423	biolink:PhenotypicFeature	Splenic cyst	A closed sac located in the spleen.	UMLS:C0272407|SNOMEDCT_US:79040006	hp.json	Cyst on spleen	http://purl.obolibrary.org/obo/HP_0030423		
HP:0030424	biolink:PhenotypicFeature	Epididymal cyst	A smooth, extratesticular, spherical cyst in the head of the epididymis.	SNOMEDCT_US:49263001|MSH:D013088|SNOMEDCT_US:43077002|UMLS:C0037859	hp.json	Epididymal cysts	http://purl.obolibrary.org/obo/HP_0030424		
HP:0030425	biolink:PhenotypicFeature	Calcified ovarian cyst	A cyst of the ovary that exhibits deposition of calcium salts.	UMLS:C4072939	hp.json		http://purl.obolibrary.org/obo/HP_0030425		
OBO:MAXO_0000138	biolink:NamedThing	contrast-enhanced ultrasound procedure	Ultrasound imaging following the administration of a microbubble contrast agent.	NCIT:C148281	hp.json	CEUS	http://purl.obolibrary.org/obo/MAXO_0000138		
OBO:MAXO_0000137	biolink:NamedThing	positron emission tomography procedure	A technique for measuring the gamma radiation produced by collisions of electrons and positrons (anti-electrons) within living tissue. In positron emission tomography (PET), a subject is given a dose of a positron-emitting radionuclide attached to a metabolically active substance (for example, 2-fluoro-2-deoxy-D-glucose (FDG), which is similar to a naturally occurring sugar, glucose, with the addition of a radioactive fluorine atom). When living tissue containing the positron emitter is bombarded by electrons, gamma radiation produced by collisions of electrons and positrons is detected by a scanner, revealing in fine detail the tissue location of the metabolically-active substance administered.	NCIT:C17007	hp.json	PET scan	http://purl.obolibrary.org/obo/MAXO_0000137		
GO:0008348	biolink:BiologicalProcess	negative regulation of antimicrobial humoral response	Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.		hp.json	attenuation of antimicrobial humoral response|down regulation of antimicrobial humoral response|inhibition of antimicrobial humoral response|down-regulation of antimicrobial humoral response|downregulation of antimicrobial humoral response	http://purl.obolibrary.org/obo/GO_0008348		
GO:0008347	biolink:BiologicalProcess	glial cell migration	The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.		hp.json	glia cell migration	http://purl.obolibrary.org/obo/GO_0008347		
HP:0030430	biolink:PhenotypicFeature	Neuroma	A tumor made up of nerve cells and nerve fibers.	SNOMEDCT_US:274089002|UMLS:C0273482|SNOMEDCT_US:84116009|MSH:D009463|SNOMEDCT_US:443892003|SNOMEDCT_US:25169009|UMLS:C0027858	hp.json	Nerve tumour|Nerve tumor|Pinched nerve	http://purl.obolibrary.org/obo/HP_0030430		
HP:0030431	biolink:PhenotypicFeature	Osteochondroma	A cartilage capped bony outgrowth of a long bone. Osteochondroma arises on the external surface of bone containing a marrow cavity that is continuous with that of the underlying bone.	SNOMEDCT_US:443093007|UMLS:C0029423|SNOMEDCT_US:52299001|MSH:D015831|SNOMEDCT_US:307573009	hp.json	Osteochondromas|Osteocartilaginous exostoses	http://purl.obolibrary.org/obo/HP_0030431		
HP:0030432	biolink:PhenotypicFeature	Chondroblastoma	A usually benign tumor composed of cells which arise from chondroblasts or their precursors and which tend to differentiate into cartilage cells.	MSH:D002804|SNOMEDCT_US:9001003|UMLS:C0008441	hp.json		http://purl.obolibrary.org/obo/HP_0030432		
HP:0030437	biolink:PhenotypicFeature	Anal canal neoplasm		UMLS:C0345883|NCIT:C3262|SNOMEDCT_US:126850006	hp.json	Anal canal tumour|Anal canal tumor	http://purl.obolibrary.org/obo/HP_0030437		
HP:0030438	biolink:PhenotypicFeature	Anal canal squamous cell carcinoma	A squamous cell carcinoma that originates in the anal canal.	UMLS:C1332262	hp.json		http://purl.obolibrary.org/obo/HP_0030438		
HP:0030439	biolink:PhenotypicFeature	Anal canal adenocarcinoma	An adenoma carcinoma that originates in the anal canal.	UMLS:C1332259|NCIT:C2852	hp.json		http://purl.obolibrary.org/obo/HP_0030439		
HP:0030433	biolink:PhenotypicFeature	Osteoid osteoma	A bening tumor of bone composed of a central zone named nidus which is an atypical bone completely enclosed within a well vascularized stroma and a peripheral sclerotic reaction zone.	SNOMEDCT_US:302859004|MSH:D010017|UMLS:C0029441|SNOMEDCT_US:71666005	hp.json		http://purl.obolibrary.org/obo/HP_0030433		
HP:0030434	biolink:PhenotypicFeature	Pilomatrixoma	Pilomatricoma is an asymptomatic slowly growing benign cutaneous tumor, differentiating towards the hair matrix of the hair follicle. It is covered by normal or hyperemic skin, and usually varies in size from 0.5 to 3 cm.	UMLS:C0206711|MSH:D018296|SNOMEDCT_US:274901004|SNOMEDCT_US:44155009	hp.json		http://purl.obolibrary.org/obo/HP_0030434		
HP:0030436	biolink:PhenotypicFeature	Fibrofolliculoma	Fibrofolliculoma is a clinically asymptomatic, 2-4 mm, skin-colored, dome-shaped smooth papule. It usually arises in the form of multiple lesions in adults in different areas such as the scalp, forehead, face, and neck. According to histology, the lesion is a fibrotic hamartoma characterized by infundibular epithelial proliferation and perifollicular fibrous proliferation.	SNOMEDCT_US:254699007|SNOMEDCT_US:128683008|UMLS:C0346011	hp.json	Fibrofolliculomas	http://purl.obolibrary.org/obo/HP_0030436		
HP:0030440	biolink:PhenotypicFeature	Anal margin neoplasm	A tumor of the anal margin.	UMLS:C2064234	hp.json		http://purl.obolibrary.org/obo/HP_0030440		
HP:0030441	biolink:PhenotypicFeature	Anal margin Paget's disease	An intraepithelial adenocarcinoma originating in the anal margin and characterized by presence of typical Paget's cells, appearing as large rounded vacuolated cells.	UMLS:C1332270	hp.json		http://purl.obolibrary.org/obo/HP_0030441		
HP:0030442	biolink:PhenotypicFeature	Anal margin squamous cell carcinoma	A squamous cell carcinoma that originates in the skin of the anal margin.	UMLS:C1412037|SNOMEDCT_US:255084004	hp.json		http://purl.obolibrary.org/obo/HP_0030442		
GO:0008356	biolink:BiologicalProcess	asymmetric cell division	The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.	Wikipedia:Asymmetric_cell_division	hp.json	asymmetrical cell division|asymmetric cytokinesis|asymmetrical cytokinesis	http://purl.obolibrary.org/obo/GO_0008356		
HP:0030443	biolink:PhenotypicFeature	Anal margin basal cell carcinoma	A basal cell carcinoma that originates in the anal margin.	UMLS:C1332269	hp.json		http://purl.obolibrary.org/obo/HP_0030443		
GO:0008354	biolink:BiologicalProcess	germ cell migration	The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.		hp.json	primordial germ cell migration|germ-cell migration	http://purl.obolibrary.org/obo/GO_0008354		
HP:0030448	biolink:PhenotypicFeature	Soft tissue sarcoma	A type of sarcoma (A connective tissue neoplasm formed by proliferation of mesodermal cells) that develops from soft tissues like fat, muscle, nerves, fibrous tissues, blood vessels, or deep skin tissues.	UMLS:C1261473|SNOMEDCT_US:424413001|SNOMEDCT_US:2424003|MSH:D012509|SNOMEDCT_US:269469005|SNOMEDCT_US:424952003	hp.json	Soft tissue sarcomas	http://purl.obolibrary.org/obo/HP_0030448		
CHEBI:83563	biolink:ChemicalSubstance	long-chain alkane	Any alkane having a chain length of at least 13 carbon atoms.		hp.json	a long-chain alkane	http://purl.obolibrary.org/obo/CHEBI_83563		3_STAR
HP:0030449	biolink:PhenotypicFeature	Therapeutic abortion	Delivery by means of therapeutic termination of pregnancy. Therapeutic abortion may be done to end a pregnancy if the mother's life is in danger or if the baby has abnormalities involving the major organ systems and is not expected to survive after birth or by choice.	MSH:D000032|SNOMEDCT_US:386641000|UMLS:C0000820	hp.json		http://purl.obolibrary.org/obo/HP_0030449		
HP:0030444	biolink:PhenotypicFeature	Anal margin melanoma	A melanoma that originates in the anal margin.	UMLS:C4072941	hp.json		http://purl.obolibrary.org/obo/HP_0030444		
HP:0030445	biolink:PhenotypicFeature	Pulmonary carcinoid tumor	A malignant neuroendocrine tumor of the lung. According to histopathologic criteria (WHO 2004), carcinoids are divided into four groups i.e. typical and atypical carcinoids, large cell neuroendocrine carcinoma and small cell lung carcinoma.	SNOMEDCT_US:254627002|UMLS:C0280089	hp.json	Lung carcinoid tumour|Pulmonary carcinoid tumour|Lung carcinoid tumor	http://purl.obolibrary.org/obo/HP_0030445		
HP:0030446	biolink:PhenotypicFeature	Atypical pulmonary carcinoid tumor		UMLS:C4072942	hp.json	Atypical pulmonary carcinoid tumour	http://purl.obolibrary.org/obo/HP_0030446		
HP:0030447	biolink:PhenotypicFeature	Merkel cell skin cancer	A malignant cutaneous tumor of the elderly that is characterized by an aggressive course with regional nodal involvement, distant metastases and a high rate of recurrence. Most patients present with rapidly growing, painless, firm, non-tender, dome-shaped red, occasionally ulcerated skin nodules, which have a red or bluish color, measuring up to several centimeters, on predominantly sun-exposed areas of the body. The overlying skin is smooth and shiny, sometimes exhibiting ulcerative, acneiform or telangiectatic features.	SNOMEDCT_US:5052009|MSH:D015266|UMLS:C0007129|SNOMEDCT_US:254729005|SNOMEDCT_US:253001006	hp.json	Primary small cell carcinoma of the skin|Primary undifferentiated carcinoma of the skin|Cutaneous APUDoma|Merkel cell cancer of the skin|Neuroendocrine carcinoma of the skin|Neuroendocrine tumor of the skin|Neuroendocrine tumour of the skin|Anaplastic carcinoma of the skin	http://purl.obolibrary.org/obo/HP_0030447		
HP:0005409	biolink:PhenotypicFeature	obsolete Markedly reduced T cell function			hp.json		http://purl.obolibrary.org/obo/HP_0005409		
HP:0005404	biolink:PhenotypicFeature	Increased B cell count	An abnormal increase from the normal count of B cells.	UMLS:C1858972	hp.json	Increase in B cell number|Increase in B cell count|Increased number of B cells	http://purl.obolibrary.org/obo/HP_0005404		
HP:0005406	biolink:PhenotypicFeature	Recurrent bacterial skin infections	Increased susceptibility to bacterial infections of the skin, as manifested by recurrent episodes of infectious dermatitis.	UMLS:C1835686	hp.json	Recurrent episodes of infectious dermatitis|Recurrent cutaneous pyogenic infections|Recurrent bacterial skin infections|Recurrent episodes of impetigo|Recurrent pyogenic skin infections	http://purl.obolibrary.org/obo/HP_0005406		
HP:0005407	biolink:PhenotypicFeature	Decreased proportion of CD4-positive helper T cells	A decreased proportion of circulating CD4-positive helper T cells relative to total T cell count.	UMLS:C1839304	hp.json	CD4+ T-cell lymphopenia|Abnormality of CD4+ T cells|CD4 T cell lymphopenia	http://purl.obolibrary.org/obo/HP_0005407		
HP:0005400	biolink:PhenotypicFeature	Reduction of neutrophil motility	An abnormal reduction of the cell motility of neutrophils.	UMLS:C4025201	hp.json		http://purl.obolibrary.org/obo/HP_0005400		
HP:0005401	biolink:PhenotypicFeature	Recurrent candida infections	An increased susceptibility to candida infections, as manifested by a history of recurrent episodes of candida infections.	UMLS:C1860128	hp.json	Frequent candida infections	http://purl.obolibrary.org/obo/HP_0005401		
HP:0005402	biolink:PhenotypicFeature	obsolete Primary T-lymphocyte immune abnormalities			hp.json		http://purl.obolibrary.org/obo/HP_0005402		
HP:0005403	biolink:PhenotypicFeature	T lymphocytopenia	An abnormally low count of T cells.	UMLS:C2931322|MSH:C536783	hp.json	Decreased numbers of circulating T cells|Reduced number of T cells|Decrease in T cell count|Decrease in T cell number|Low T cell count	http://purl.obolibrary.org/obo/HP_0005403		
CHEBI:22506	biolink:ChemicalSubstance	aminoglycan			hp.json	aminoglycans	http://purl.obolibrary.org/obo/CHEBI_22506		3_STAR
HP:0005419	biolink:PhenotypicFeature	Decreased T cell activation	Decreased or impaired activation of T cells in response to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.	UMLS:C1846550	hp.json	Defective T cell activation|Profound depletion of T4+ lymphocytes|Decreased T-lymphocyte activation|Decreased T lymphocyte activation|Decreased T-cell activation	http://purl.obolibrary.org/obo/HP_0005419		
HP:0005415	biolink:PhenotypicFeature	Decreased proportion of CD8-positive T cells	A decreased proportion of circulating CD8-positive, alpha-beta T cells relative to total number of T cells.	UMLS:C1839305	hp.json	Decreased proportion of CD8+ T cells|Decreased proportion of CD8-positive, alpha-beta T cells|CD8+ T-cell lymphopenia	http://purl.obolibrary.org/obo/HP_0005415		
HP:0005416	biolink:PhenotypicFeature	Decreased serum complement factor B	A reduced level of the complement component factor B in circulation.	UMLS:C4021636	hp.json	Decreased serum factor b	http://purl.obolibrary.org/obo/HP_0005416		
HP:0005411	biolink:PhenotypicFeature	Chronic intestinal candidiasis	Persistent overgrowth of Candida albicans in the gastrointestinal tract.	UMLS:C4025199|UMLS:C4020823	hp.json	Candida overgrowth syndrome	http://purl.obolibrary.org/obo/HP_0005411		
HP:0005413	biolink:PhenotypicFeature	Increased alpha-globulin	An abnormally increased level of circulating alpha-globulin. Alpha globulins are a group of serum proteins defined by their mobility on serum electrophoresis. The alpha1-protein fraction is comprised of alpha1-antitrypsin, thyroid-binding globulin, and transcortin. Ceruloplasmin, alpha2-macroglobulin, and haptoglobin contribute to the alpha2-protein band. The alpha2 component is increased as an acute-phase reactant.	UMLS:C1167806|SNOMEDCT_US:124022007	hp.json		http://purl.obolibrary.org/obo/HP_0005413		
GO:0070295	biolink:NamedThing	renal water absorption			hp.json		http://purl.obolibrary.org/obo/GO_0070295		
GO:0070293	biolink:BiologicalProcess	renal absorption	A renal system process in which water, ions, glucose and proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).		hp.json	renal reabsorption|nephron absorption	http://purl.obolibrary.org/obo/GO_0070293		
NCBITaxon:33511	biolink:OrganismalEntity	Deuterostomia		GC_ID:1	hp.json	deuterostomes	http://purl.obolibrary.org/obo/NCBITaxon_33511		
GO:0070285	biolink:BiologicalProcess	pigment cell development	The process whose specific outcome is the progression of a pigment cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a pigment cell fate.		hp.json		http://purl.obolibrary.org/obo/GO_0070285		
HP:0030404	biolink:PhenotypicFeature	Glucagonoma	An endocrine tumor of the pancreas that secretes excessive amounts of glucagon.	MSH:D005935|SNOMEDCT_US:128855009|SNOMEDCT_US:302823005|UMLS:C0017689|SNOMEDCT_US:16424000	hp.json		http://purl.obolibrary.org/obo/HP_0030404		
HP:0030405	biolink:PhenotypicFeature	Pancreatic endocrine tumor	A neuroendocrine tumor originating in a hormone-producing cell (islet cell) of the pancreas.	SNOMEDCT_US:126864006|MSH:D007516|SNOMEDCT_US:128878003|SNOMEDCT_US:76345009|SNOMEDCT_US:399528006|UMLS:C0242363|SNOMEDCT_US:237596009	hp.json	Pancreatic endocrine tumour	http://purl.obolibrary.org/obo/HP_0030405		
GO:0033293	biolink:MolecularActivity	monocarboxylic acid binding	Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-).		hp.json		http://purl.obolibrary.org/obo/GO_0033293		
HP:0030406	biolink:PhenotypicFeature	Primary peritoneal carcinoma	A type of cancer that originates in the peritoneum. It is to be distinguished from metastatic cancer of the peritoneum. Peritoneal cancer can occur anywhere in the abdominal space, and affects the surface of organs contained inside the peritoneum.	UMLS:C1514428	hp.json		http://purl.obolibrary.org/obo/HP_0030406		
HP:0030407	biolink:PhenotypicFeature	Pineocytoma	A type of pineal parenchymal cell neoplasm that is a mature well-differentiated tumour (WHO grade I).	SNOMEDCT_US:89096009|MSH:D010871|NCIT:C6966|UMLS:C0917890|SNOMEDCT_US:255045009	hp.json		http://purl.obolibrary.org/obo/HP_0030407		
HP:0030400	biolink:PhenotypicFeature	Abnormal platelet lysosome secretion	Abnormal release of lysosome contents from platelets.	UMLS:C4072933	hp.json		http://purl.obolibrary.org/obo/HP_0030400		
HP:0030401	biolink:PhenotypicFeature	Abnormal platelet dense granule ATP/ADP ratio	Deviation from normal of the ratio of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) within platelets.	UMLS:C4072934	hp.json		http://purl.obolibrary.org/obo/HP_0030401		
HP:0030402	biolink:PhenotypicFeature	Abnormal platelet aggregation	An abnormality in the rate and degree to which platelets aggregate after the addition of an agonist that stimulates platelet clumping. Platelet aggregation is measured using aggregometer to measure the optical density of platelet-rich plasma, whereby platelet aggregation causes the plasma to become more transparent.	UMLS:C0541767	hp.json		http://purl.obolibrary.org/obo/HP_0030402		
HP:0030403	biolink:PhenotypicFeature	Spontaneous platelet aggregation	Clumping together of platelets in the blood in a platelet aggregation test without addition of agents normally used to induce aggregation.	MSH:C566800|UMLS:C1868263	hp.json		http://purl.obolibrary.org/obo/HP_0030403		
HP:0030408	biolink:PhenotypicFeature	Pineoblastoma	Pineoblastoma is a rare primitive neuroectodermal tumour (PNET) arising in the pineal gland. Pineoblastomas are classified as a WHO grade IV tumour and comprise one-fourth to one-half of pineal parenchymal tumours. Pineoblastoma is a highly cellular tumor originating in the pineal gland and containing small, poorly differentiated cells.	MSH:D010871|SNOMEDCT_US:31671006|UMLS:C0205898	hp.json	Pinealoblastoma	http://purl.obolibrary.org/obo/HP_0030408		
GO:0070288	biolink:CellularComponent	ferritin complex	A protein complex that binds iron and acts as a major iron storage system. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain.		hp.json		http://purl.obolibrary.org/obo/GO_0070288		
HP:0030409	biolink:PhenotypicFeature	Renal transitional cell carcinoma	A malignant tumor that arises from the transitional (urothelial) epithelial cells lining the urinary tract from the renal calyces to the ureteral orifice.	UMLS:C1319314|SNOMEDCT_US:408642003	hp.json	Renal urothelial carcinoma|renal TCC|Transitional renal cell carcinoma	http://purl.obolibrary.org/obo/HP_0030409		
HP:0005449	biolink:PhenotypicFeature	Bridged sella turcica		UMLS:C1866959|MSH:C566689	hp.json		http://purl.obolibrary.org/obo/HP_0005449		
HP:0005445	biolink:PhenotypicFeature	Enlarged posterior fossa	Abnormal increased size of the posterior cranial fossa.	UMLS:C1855889	hp.json	Widened posterior fossa	http://purl.obolibrary.org/obo/HP_0005445		
HP:0005446	biolink:PhenotypicFeature	Obtuse angle of mandible	Abnormally flat (obtuse) angle of the mandible. The angle of the mandibular, located at the junction between the body and the ramus of the mandible, is normally close to being a right angle. This terms describes an abnormal increase of this angle such that the mandible appears flatter than normal.	UMLS:C4038738|SNOMEDCT_US:709997007	hp.json	Steep mandibular plane angle|High mandibular plane angle	http://purl.obolibrary.org/obo/HP_0005446		
HP:0005441	biolink:PhenotypicFeature	Sclerotic cranial sutures	An increased density in the cranial sutures following obliteration.	UMLS:C4025195	hp.json		http://purl.obolibrary.org/obo/HP_0005441		
HP:0005442	biolink:PhenotypicFeature	Widely patent coronal suture	The presence of a coronal suture (the cranial suture that separates the frontal and parietal bones) that is not ossified but rather wide open at an age when it is normally closed.	UMLS:C1856778	hp.json		http://purl.obolibrary.org/obo/HP_0005442		
UBERON:3010200	biolink:AnatomicalEntity	vasculature of respiratory integument	Blood vessels in respiratory skin.		hp.json		http://purl.obolibrary.org/obo/UBERON_3010200		
HP:0005456	biolink:PhenotypicFeature	Absent ethmoidal sinuses	Lack (aplasia) of the ethmoidal sinus.	UMLS:C4025194	hp.json	Agenesis of ethmoid sinuses|Failure of development of ethmoid sinuses|Missing ethmoid sinuses	http://purl.obolibrary.org/obo/HP_0005456		
MPATH:675	biolink:NamedThing	psoriasiform dermatitis			hp.json		http://purl.obolibrary.org/obo/MPATH_675		
HP:0005458	biolink:PhenotypicFeature	Premature closure of fontanelles	Normally, the posterior and lateral fontanelles are obliterated by about six months after birth, the anterior fontanelle closes by about the middle of the second year. This term refers to the situation in which the fontanelles close at an inappropriately early time point.	SNOMEDCT_US:57219006|UMLS:C0277827|UMLS:C0010278|MSH:D003398|UMLS:C4072853|SNOMEDCT_US:1667003	hp.json	Premature closure of the cranial sutures|Premature closure of the bregma sutures|Early closure of the cranial sutures|Early closure of the fontanelles|Obliterated fontanelles|Early closure of the bregma sutures	http://purl.obolibrary.org/obo/HP_0005458		
HP:0005451	biolink:PhenotypicFeature	Decreased cranial base ossification		UMLS:C1835442	hp.json		http://purl.obolibrary.org/obo/HP_0005451		
HP:0005453	biolink:PhenotypicFeature	Absent/hypoplastic paranasal sinuses	Aplasia or hypoplasia of the paranasal sinuses.	UMLS:C1856639	hp.json		http://purl.obolibrary.org/obo/HP_0005453		hposlim_core
GO:0033278	biolink:BiologicalProcess	cell proliferation in midbrain	The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.		hp.json	mesencepahalic cell proliferation|cell proliferation in mesencephalon	http://purl.obolibrary.org/obo/GO_0033278		
HP:0005450	biolink:PhenotypicFeature	Calvarial osteosclerosis	An increase in bone density affecting the calvaria (roof of the skull).	UMLS:C1855657	hp.json		http://purl.obolibrary.org/obo/HP_0005450		
HP:0005428	biolink:PhenotypicFeature	Severe recurrent varicella		UMLS:C1833487|MSH:C563458	hp.json		http://purl.obolibrary.org/obo/HP_0005428		
HP:0005429	biolink:PhenotypicFeature	Recurrent systemic pyogenic infections	Increased susceptibility to systemic pyogenic infections, as manifested by recurrent episodes of systemic pyogenic infections.	UMLS:C4025196	hp.json		http://purl.obolibrary.org/obo/HP_0005429		
HP:0005422	biolink:PhenotypicFeature	Absence of CD8-positive T cells	Lack of detectible CD8-positive T cells	UMLS:C4025197	hp.json	Absence of CD8+ T cells	http://purl.obolibrary.org/obo/HP_0005422		
HP:0005423	biolink:PhenotypicFeature	Dysfunctional alternative complement pathway	An abnormality of the functioning of any aspect of the alternative complement pathway.	UMLS:C1839458	hp.json		http://purl.obolibrary.org/obo/HP_0005423		
HP:0005424	biolink:PhenotypicFeature	Absent specific antibody response	Absence of specific immunoglobulins directed against a specific antigen or microorganism.	UMLS:C1863246	hp.json		http://purl.obolibrary.org/obo/HP_0005424		
HP:0005425	biolink:PhenotypicFeature	Recurrent sinopulmonary infections	An increased susceptibility to infections involving both the paranasal sinuses and the lungs, as manifested by a history of recurrent sinopulmonary infections.	UMLS:C1846546	hp.json	Recurrent sinus and lung infections|Chronic sinopulmonary infection	http://purl.obolibrary.org/obo/HP_0005425		
HP:0005420	biolink:PhenotypicFeature	Recurrent gram-negative bacterial infections	Increased susceptibility to infection by gram-negative bacteria, as manifested by a medical history of repeated or frequent infections by these agents.	UMLS:C4025198	hp.json		http://purl.obolibrary.org/obo/HP_0005420		
HP:0005421	biolink:PhenotypicFeature	Decreased serum complement C3	A reduced level of the complement component C3 in circulation.	UMLS:C1837512	hp.json	Decreased serum C3|Decreased serum complement C3 level	http://purl.obolibrary.org/obo/HP_0005421		
HP:0005437	biolink:PhenotypicFeature	Recurrent infections in infancy and early childhood	Recurrent infections at an early age with improvement in later childhood.	UMLS:C1844909	hp.json		http://purl.obolibrary.org/obo/HP_0005437		
HP:0005439	biolink:PhenotypicFeature	Maxillozygomatic hypoplasia	Hypoplasia of the maxillozygomatic complex.	UMLS:C4280488|UMLS:C1848908	hp.json	Decreased size of zygomaticomaxillary bone complex|Deficiency of zygomaticomaxillary bone complex|Hypoplasia of malar bone complex|Decreased projection of zygomaticomaxillary bone complex|Underdevelopment of zygomaticomaxillary bone complex|Hypoplasia of zygomaticomaxillary complex	http://purl.obolibrary.org/obo/HP_0005439		
HP:0005435	biolink:PhenotypicFeature	Impaired T cell function	Abnormally reduced ability of T cells to perform their functions in cell-mediated immunity.	UMLS:C1860127	hp.json	T-cell dysfunction|Impaired T cell function	http://purl.obolibrary.org/obo/HP_0005435		
HP:0005430	biolink:PhenotypicFeature	Recurrent Neisserial infections	Recurrent infections by bacteria of the genus Neisseria, including N. meningitidis (one of the most common causes of bacterial meningitis).	UMLS:C3151083	hp.json	Recurrent neisseria infections|Episodes of neisserial infection	http://purl.obolibrary.org/obo/HP_0005430		
HP:0005432	biolink:PhenotypicFeature	Transient hypogammaglobulinemia of infancy	At birth, newborns are endowed with maternal antibodies. IgG production normally begins at the age of two months. A delay in recovery from this physiological hypogammaglobulinemia between the 3rd and the 6th month of life, and of recovery period between 18 and 36 months defines transient newborn hypogammaglobulinemia.	UMLS:C4020822|SNOMEDCT_US:88714009|UMLS:C0272238	hp.json	Newborn gammaglobulin deficiency	http://purl.obolibrary.org/obo/HP_0005432		
CHEBI:22586	biolink:ChemicalSubstance	antioxidant	A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.		hp.json	antoxidant|antioxidants|antioxydant	http://purl.obolibrary.org/obo/CHEBI_22586		3_STAR
CHEBI:22587	biolink:ChemicalSubstance	antiviral agent	A substance that destroys or inhibits replication of viruses.		hp.json	antivirals|antiviral|antiviral agents|anti-viral agent|anti-viral agents	http://purl.obolibrary.org/obo/CHEBI_22587		3_STAR
GO:1901963	biolink:BiologicalProcess	regulation of cell proliferation involved in outflow tract morphogenesis	Any process that modulates the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_1901963		
GO:1901964	biolink:BiologicalProcess	positive regulation of cell proliferation involved in outflow tract morphogenesis	Any process that activates or increases the frequency, rate or extent of cell proliferation involved in outflow tract morphogenesis.		hp.json	upregulation of cell proliferation involved in outflow tract morphogenesis|up regulation of cell proliferation involved in outflow tract morphogenesis|up-regulation of cell proliferation involved in outflow tract morphogenesis|activation of cell proliferation involved in outflow tract morphogenesis	http://purl.obolibrary.org/obo/GO_1901964		
UBERON:0003571	biolink:AnatomicalEntity	trachea connective tissue	A portion of connective tissue that is part of a trachea.	EMAPA:35876|MA:0001853	hp.json	connective tissue of windpipe|connective tissue of trachea	http://purl.obolibrary.org/obo/UBERON_0003571		
UBERON:0003572	biolink:AnatomicalEntity	chest connective tissue	A portion of connective tissue that is part of a chest [Automatically generated definition].	EMAPA:37254|MA:0000550	hp.json	portion of connective tissue of anterior thoracic region|anterolateral part of thorax portion of connective tissue|connective tissue of anterior thoracic region|textus connectivus of chest|textus connectivus of anterolateral part of thorax|front of thorax connective tissue|anterior thoracic region textus connectivus|front of thorax portion of connective tissue|textus connectivus of front of thorax|chest portion of connective tissue|anterolateral part of thorax connective tissue|anterolateral part of thorax textus connectivus|textus connectivus of anterior thoracic region|portion of connective tissue of chest|connective tissue of chest|connective tissue of front of thorax|anterior thoracic region connective tissue|front of thorax textus connectivus|portion of connective tissue of front of thorax|chest textus connectivus|connective tissue of anterolateral part of thorax|anterior thoracic region portion of connective tissue|portion of connective tissue of anterolateral part of thorax	http://purl.obolibrary.org/obo/UBERON_0003572		
UBERON:0003570	biolink:AnatomicalEntity	respiratory system connective tissue	A portion of connective tissue that is part of a respiratory system [Automatically generated definition].	EMAPA:35968|EMAPA:35977|MA:0001814	hp.json	connective tissue of respiratory system|portion of connective tissue of respiratory system|apparatus respiratorius textus connectivus|respiratory system portion of connective tissue|apparatus respiratorius connective tissue|textus connectivus of apparatus respiratorius|textus connectivus of respiratory system|apparatus respiratorius portion of connective tissue|respiratory system textus connectivus|connective tissue of apparatus respiratorius|portion of connective tissue of apparatus respiratorius	http://purl.obolibrary.org/obo/UBERON_0003570		
UBERON:0003579	biolink:AnatomicalEntity	shoulder connective tissue	A portion of connective tissue that is part of a shoulder [Automatically generated definition].	EMAPA:37315|MA:0000632	hp.json	textus connectivus of shoulder|shoulder portion of connective tissue|portion of connective tissue of shoulder|shoulder textus connectivus|connective tissue of shoulder	http://purl.obolibrary.org/obo/UBERON_0003579		
UBERON:0003577	biolink:AnatomicalEntity	knee connective tissue	A portion of connective tissue that is part of a knee [Automatically generated definition].	EMAPA:37326|MA:0000667	hp.json	knee portion of connective tissue|connective tissue of knee	http://purl.obolibrary.org/obo/UBERON_0003577		
UBERON:0003578	biolink:AnatomicalEntity	pedal digit connective tissue	A portion of connective tissue that is part of a toe [Automatically generated definition].	MA:0000647|EMAPA:37330	hp.json	digitus pedis textus connectivus|connective tissue of foot digit|connective tissue of toe|connective tissue of digitus pedis|connective tissue of digit of foot|foot digit connective tissue|hind limb digit connective tissue|foot digit connective tissue	http://purl.obolibrary.org/obo/UBERON_0003578		
UBERON:0003575	biolink:AnatomicalEntity	wrist connective tissue	A portion of connective tissue that is part of a wrist [Automatically generated definition].	EMAPA:37320|MA:0000636	hp.json	carpal region connective tissue|connective tissue of wrist|connective tissue of carpal region	http://purl.obolibrary.org/obo/UBERON_0003575		
UBERON:0003576	biolink:AnatomicalEntity	hip connective tissue	A portion of connective tissue that is part of a hip [Automatically generated definition].	EMAPA:37323|MA:0000656	hp.json	connective tissue of regio coxae|connective tissue of hip region|connective tissue of hip	http://purl.obolibrary.org/obo/UBERON_0003576		
UBERON:0003573	biolink:AnatomicalEntity	arm connective tissue	A portion of connective tissue that is part of an arm [Automatically generated definition].	MA:0000593|EMAPA:37316	hp.json		http://purl.obolibrary.org/obo/UBERON_0003573		
UBERON:0003574	biolink:AnatomicalEntity	elbow connective tissue	A portion of connective tissue that is part of a elbow [Automatically generated definition].	MA:0000609|EMAPA:37318	hp.json	textus connectivus of cubital region|connective tissue of elbow|connective tissue of cubital region	http://purl.obolibrary.org/obo/UBERON_0003574		
UBERON:0003559	biolink:AnatomicalEntity	hindbrain arachnoid mater	An arachnoid mater that is part of a hindbrain [Automatically generated definition].	EMAPA:17784|VHOG:0000236|MA:0000988	hp.json	hindbrain arachnoid|rhombencephalon arachnoid mater|hindbrain arachnoid mater of neuraxis|arachnoid mater of neuraxis of hindbrain|arachnoid mater of hindbrain|arachnoid of hindbrain	http://purl.obolibrary.org/obo/UBERON_0003559		
UBERON:0003560	biolink:AnatomicalEntity	spinal cord arachnoid mater	An arachnoid mater that is part of a spinal cord [Automatically generated definition].	MA:0001131|EMAPA:17805|VHOG:0000234	hp.json	arachnoid mater of spinal cord|arachnoid of spinal cord|spinal cord arachnoid|spinal cord arachnoid mater of neuraxis|arachnoid mater of neuraxis of spinal cord	http://purl.obolibrary.org/obo/UBERON_0003560		organ_slim
UBERON:0003561	biolink:AnatomicalEntity	forebrain dura mater	A dura mater that is part of a forebrain.	EMAPA:37545|EMAPA:17766|MA:0000885	hp.json	dura mater of neuraxis of forebrain|dura mater of forebrain|forebrain dura mater of neuraxis	http://purl.obolibrary.org/obo/UBERON_0003561		
UBERON:0003568	biolink:AnatomicalEntity	neck connective tissue	A portion of connective tissue that is part of a neck [Automatically generated definition].	MA:0000585|EMAPA:37250	hp.json	portion of connective tissue of neck|neck (volume) connective tissue|textus connectivus of neck (volume)|connective tissue of neck|neck (volume) portion of connective tissue|textus connectivus of neck|connective tissue of neck (volume)|neck portion of connective tissue|neck (volume) textus connectivus|portion of connective tissue of neck (volume)|neck textus connectivus	http://purl.obolibrary.org/obo/UBERON_0003568		
UBERON:0003569	biolink:AnatomicalEntity	leg connective tissue	A portion of connective tissue that is part of a leg [Automatically generated definition].	MA:0000671|EMAPA:37324	hp.json	connective tissue of leg|portion of connective tissue of leg|leg portion of connective tissue|textus connectivus of leg|leg textus connectivus	http://purl.obolibrary.org/obo/UBERON_0003569		
UBERON:0003566	biolink:AnatomicalEntity	head connective tissue	A portion of connective tissue that is part of a head [Automatically generated definition].	EMAPA:16098|MA:0000577	hp.json	adult head connective tissue|adult head textus connectivus|textus connectivus of head|head portion of connective tissue|connective tissue of adult head|portion of connective tissue of adult head|adult head portion of connective tissue|head textus connectivus|connective tissue of head|portion of connective tissue of head|textus connectivus of adult head	http://purl.obolibrary.org/obo/UBERON_0003566		
UBERON:0003567	biolink:AnatomicalEntity	abdomen connective tissue	A portion of connective tissue that is part of an abdomen [Automatically generated definition].	MA:0000519	hp.json	abdomen portion of connective tissue|connective tissue of abdomen|portion of connective tissue of abdomen|abdomen textus connectivus|textus connectivus of abdomen	http://purl.obolibrary.org/obo/UBERON_0003567		
UBERON:0003564	biolink:AnatomicalEntity	diencephalon dura mater	A dura mater that is part of a diencephalon [Automatically generated definition].	MA:0000828|VHOG:0000258|EMAPA:17766	hp.json	between brain dura mater of neuraxis|dura mater of neuraxis of between brain|diencephalon dura mater of neuraxis|dura mater of between brain|dura mater of diencephalon|dura mater of neuraxis of diencephalon|dura mater of neuraxis of mature diencephalon|dura mater of mature diencephalon|interbrain dura mater|mature diencephalon dura mater|mature diencephalon dura mater of neuraxis|interbrain dura mater of neuraxis|dura mater of interbrain|between brain dura mater|dura mater of neuraxis of interbrain	http://purl.obolibrary.org/obo/UBERON_0003564		
UBERON:0003565	biolink:AnatomicalEntity	hindbrain dura mater	A dura mater that is part of a hindbrain [Automatically generated definition].	VHOG:0000409|MA:0000989|EMAPA:17785	hp.json	hindbrain dura mater of neuraxis|dura mater of neuraxis of hindbrain|dura mater of hindbrain|rhombencephalon dura mater	http://purl.obolibrary.org/obo/UBERON_0003565		
UBERON:0003562	biolink:AnatomicalEntity	midbrain dura mater	A dura mater that is part of a midbrain [Automatically generated definition].	EMAPA:17793|VHOG:0000410|MA:0001060	hp.json	dura mater of midbrain|dura mater of neuraxis of midbrain|mesencephalon dura mater|midbrain dura mater of neuraxis	http://purl.obolibrary.org/obo/UBERON_0003562		
UBERON:0003563	biolink:AnatomicalEntity	telencephalon dura mater	A dura mater that is part of a telencephalon [Automatically generated definition].	MA:0000981|EMAPA:17776	hp.json	dura mater of neuraxis of telencephalon|telencephalon dura mater of neuraxis|dura mater of telencephalon	http://purl.obolibrary.org/obo/UBERON_0003563		
CHEBI:22563	biolink:ChemicalSubstance	anion	A monoatomic or polyatomic species having one or more elementary charges of the electron.		hp.json	anion|aniones|anions|Anionen|Anion|anion	http://purl.obolibrary.org/obo/CHEBI_22563		3_STAR
HP:0500097	biolink:PhenotypicFeature	Stool xenobiotic	Presence of xenobiotic in stool.		hp.json		http://purl.obolibrary.org/obo/HP_0500097		
HP:0500098	biolink:PhenotypicFeature	Meconium xenobiotic	Presence of a xenobiotic in meconium.		hp.json		http://purl.obolibrary.org/obo/HP_0500098		
HP:0500095	biolink:PhenotypicFeature	Food-induced anaphylaxis	Food-induced anaphylaxis is a severe, potentially fatal, systemic allergic reaction that occurs suddenly after contact with an allergy-causing food.		hp.json		http://purl.obolibrary.org/obo/HP_0500095		
HP:0500096	biolink:PhenotypicFeature	Venom-induced anaphylaxis	A form of anaphylaxis that is triggered by exposure to venom.		hp.json		http://purl.obolibrary.org/obo/HP_0500096		
UBERON:0003548	biolink:AnatomicalEntity	forebrain meninges	A meninx that is part of a forebrain [Automatically generated definition].	EMAPA:17764|EMAPA:17774|MA:0000883|EMAPA:37543	hp.json	meninges of forebrain|meninx of forebrain|forebrain meninx	http://purl.obolibrary.org/obo/UBERON_0003548		
HP:0500099	biolink:PhenotypicFeature	Hair xenobiotic	Presence of xenobiotic in hair.		hp.json		http://purl.obolibrary.org/obo/HP_0500099		
UBERON:0003549	biolink:AnatomicalEntity	brain pia mater	The fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule.	VHOG:0000470|EV:0100315|EMAPA:32667|MA:0000816|NCIT:C49335|UMLS:C1706994	hp.json	pia mater of neuraxis of brain|brain pia mater of neuraxis|pia mater of brain	http://purl.obolibrary.org/obo/UBERON_0003549		pheno_slim
GO:0045259	biolink:CellularComponent	proton-transporting ATP synthase complex	A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.		hp.json	F1-F0 complex|hydrogen-transporting ATP synthase complex|proton-transporting F-type ATPase complex|hydrogen-translocating F-type ATPase complex	http://purl.obolibrary.org/obo/GO_0045259		
UBERON:0003550	biolink:AnatomicalEntity	forebrain pia mater	A pia mater that is part of a forebrain [Automatically generated definition].	EMAPA:37546|EMAPA:17767|EMAPA:17777|MA:0000886	hp.json	forebrain pia mater of neuraxis|pia mater of forebrain|pia mater of neuraxis of forebrain	http://purl.obolibrary.org/obo/UBERON_0003550		
GO:0060896	biolink:BiologicalProcess	neural plate pattern specification	The developmental process that results in the creation of defined areas or spaces within the neural plate to which cells respond and eventually are instructed to differentiate.		hp.json		http://purl.obolibrary.org/obo/GO_0060896		
GO:0060897	biolink:BiologicalProcess	neural plate regionalization	The pattern specification process that results in the subdivision of an axis or axes of the neural plate in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.		hp.json		http://purl.obolibrary.org/obo/GO_0060897		
UBERON:0003557	biolink:AnatomicalEntity	midbrain arachnoid mater	An arachnoid mater that is part of a midbrain [Automatically generated definition].	MA:0001059|EMAPA:17792|VHOG:0000233	hp.json	mesencephalon arachnoid mater|midbrain arachnoid|midbrain arachnoid mater of neuraxis|arachnoid of midbrain|arachnoid mater of midbrain|arachnoid mater of neuraxis of midbrain	http://purl.obolibrary.org/obo/UBERON_0003557		
MPATH:622	biolink:NamedThing	steatosis	Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells.		hp.json	fatty change|adipose degeneration|lipidosis|fatty degeneration	http://purl.obolibrary.org/obo/MPATH_622		
UBERON:0003558	biolink:AnatomicalEntity	diencephalon arachnoid mater	An arachnoid mater that is part of a diencephalon [Automatically generated definition].	VHOG:0000231|EMAPA:17765|MA:0000827	hp.json	arachnoid mater of interbrain|arachnoid of mature diencephalon|between brain arachnoid|arachnoid mater of neuraxis of interbrain|diencephalon arachnoid mater of neuraxis|between brain arachnoid mater|arachnoid of diencephalon|interbrain arachnoid|mature diencephalon arachnoid|between brain arachnoid mater of neuraxis|arachnoid mater of diencephalon|arachnoid mater of neuraxis of between brain|mature diencephalon arachnoid mater|interbrain arachnoid mater|arachnoid mater of neuraxis of diencephalon|arachnoid mater of between brain|mature diencephalon arachnoid mater of neuraxis|interbrain arachnoid mater of neuraxis|arachnoid mater of neuraxis of mature diencephalon|arachnoid of between brain|arachnoid of interbrain|diencephalon arachnoid|arachnoid mater of mature diencephalon	http://purl.obolibrary.org/obo/UBERON_0003558		
UBERON:0003555	biolink:AnatomicalEntity	spinal cord pia mater	A pia mater that is part of a spinal cord [Automatically generated definition].	EHDAA2:0001896|NCIT:C49800|MA:0001133|EMAPA:17807|UMLS:C1710148|VHOG:0000468	hp.json	pia mater of neuraxis of spinal cord|spinal cord pia mater of neuraxis|pia mater of spinal cord	http://purl.obolibrary.org/obo/UBERON_0003555		organ_slim
UBERON:0003556	biolink:AnatomicalEntity	forebrain arachnoid mater	An arachnoid mater that is part of a forebrain [Automatically generated definition].	EMAPA:17775|MA:0000884|EMAPA:37544|EMAPA:17765	hp.json	arachnoid of forebrain|forebrain arachnoid|forebrain arachnoid mater of neuraxis|arachnoid mater of neuraxis of forebrain|arachnoid mater of forebrain	http://purl.obolibrary.org/obo/UBERON_0003556		
UBERON:0003553	biolink:AnatomicalEntity	diencephalon pia mater	A pia mater that is part of a diencephalon [Automatically generated definition].	EHDAA2:0000400|MA:0000829|EMAPA:17767|VHOG:0000475	hp.json	pia mater of neuraxis of diencephalon|pia mater of neuraxis of mature diencephalon|mature diencephalon pia mater of neuraxis|interbrain pia mater of neuraxis|pia mater of mature diencephalon|pia mater of interbrain|pia mater of neuraxis of interbrain|diencephalon pia mater of neuraxis|between brain pia mater|pia mater of neuraxis of between brain|between brain pia mater of neuraxis|pia mater of diencephalon|pia mater of between brain|mature diencephalon pia mater|interbrain pia mater	http://purl.obolibrary.org/obo/UBERON_0003553		
UBERON:0003554	biolink:AnatomicalEntity	hindbrain pia mater	A pia mater that is part of a hindbrain [Automatically generated definition].	MA:0000990|EHDAA2:0000772|VHOG:0000466|EMAPA:17786	hp.json	rhombencephalon pia mater|pia mater of neuraxis of hindbrain|hindbrain pia mater of neuraxis|pia mater of hindbrain	http://purl.obolibrary.org/obo/UBERON_0003554		
UBERON:0003551	biolink:AnatomicalEntity	midbrain pia mater	A pia mater that is part of a midbrain [Automatically generated definition].	EMAPA:17794|RETIRED_EHDAA2:0001110|EHDAA2:0001175|VHOG:0000467|MA:0001061	hp.json	pia mater of midbrain|pia mater of neuraxis of midbrain|mesencephalon pia mater|midbrain pia mater of neuraxis	http://purl.obolibrary.org/obo/UBERON_0003551		
UBERON:0003552	biolink:AnatomicalEntity	telencephalon pia mater	A pia mater that is part of a telencephalon [Automatically generated definition].	MA:0000982|EHDAA2:0001992|VHOG:0000476|EMAPA:17777	hp.json	pia mater of neuraxis of telencephalon|telencephalon pia mater of neuraxis|pia mater of telencephalon	http://purl.obolibrary.org/obo/UBERON_0003552		
MPATH:608	biolink:NamedThing	abscess	A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation.		hp.json		http://purl.obolibrary.org/obo/MPATH_608		
HP:0500086	biolink:PhenotypicFeature	Optic nerve gray crescent	Having a characteristic appearance of a slate gray area of pigmentation within the disc margins that commonly appears along the inferotemporal or temporal neuroretinal rim areas.		hp.json	Optic nerve grey crescent|Temporal gray pigmentary crescent|Temporal grey pigmentary crescent	http://purl.obolibrary.org/obo/HP_0500086		
MPATH:607	biolink:NamedThing	healing and repair structure	Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage.		hp.json		http://purl.obolibrary.org/obo/MPATH_607		
HP:0500087	biolink:PhenotypicFeature	Peripapillary atrophy	Thinning in the layers of the retina and retinal pigment epithelium around the optic nerve.		hp.json		http://purl.obolibrary.org/obo/HP_0500087		
GO:0045260	biolink:CellularComponent	plasma membrane proton-transporting ATP synthase complex	A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species.		hp.json	hydrogen-transporting ATP synthase|hydrogen-translocating F-type ATPase complex|proton-transporting ATP synthase complex|plasma membrane hydrogen-translocating F-type ATPase complex	http://purl.obolibrary.org/obo/GO_0045260		
UBERON:0003539	biolink:AnatomicalEntity	left lung bronchiole	A bronchiole that is part of a left lung [Automatically generated definition].	NCIT:C49252|MA:0001778|UMLS:C0225674|EMAPA:19000	hp.json	left lung lobular bronchiole|bronchiole of left lung|lobular bronchiole of left lung	http://purl.obolibrary.org/obo/UBERON_0003539		
HP:0500088	biolink:PhenotypicFeature	Foveal depigmentation	Loss of pigment in the fovea centralis.		hp.json		http://purl.obolibrary.org/obo/HP_0500088		
HP:0500089	biolink:PhenotypicFeature	Optic nerve sheath meningioma	A benign tumour of meningothelial cells of the meninges that usually occurs in middle age. It is typically unilateral and there is an association with neurofibromatosis type 2.		hp.json		http://purl.obolibrary.org/obo/HP_0500089		
UBERON:0003538	biolink:AnatomicalEntity	right lung bronchiole	A bronchiole that is part of a right lung [Automatically generated definition].	MA:0001787|UMLS:C0225670|NCIT:C49279|EMAPA:35425	hp.json	bronchiole of right lung|lobular bronchiole of right lung|right lung lobular bronchiole	http://purl.obolibrary.org/obo/UBERON_0003538		
HP:0500090	biolink:PhenotypicFeature	Periocular capillary hemangioma	A capillary hemangioma surrounding the eyeball but within the orbit.		hp.json	Peri-ocular capillary hemangioma	http://purl.obolibrary.org/obo/HP_0500090		
UBERON:0003547	biolink:AnatomicalEntity	brain meninx	A meninx that is part of a brain [Automatically generated definition].	CALOHA:TS-2147|EV:0100312|SCTID:180949007|MA:0000813|EMAPA:32662|VHOG:0000013	hp.json	meninx of brain|brain meninges|meninges of brain	http://purl.obolibrary.org/obo/UBERON_0003547		organ_slim|pheno_slim
UBERON:0003544	biolink:AnatomicalEntity	brain white matter	The regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites.	MA:0000820|EMAPA:35187|UMLS:C1706995|NCIT:C49334|HBA:9218	hp.json	brain white matter of neuraxis|brain white substance|white matter of neuraxis of brain|white matter of brain|white substance of brain	http://purl.obolibrary.org/obo/UBERON_0003544		pheno_slim
GO:0070202	biolink:BiologicalProcess	regulation of establishment of protein localization to chromosome	Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location on a chromosome.		hp.json	regulation of establishment of protein localisation to chromosome	http://purl.obolibrary.org/obo/GO_0070202		
HP:0500093	biolink:PhenotypicFeature	Food allergy	Primary food allergies primarily occur as a result (most likely) of gastrointestinal sensitization to predominantly stable food allergens (glycoproteins). A secondary food allergy develops after primary sensitization to airborne allergens (e. g., pollen allergens) with subsequent reactions (due to cross-reactivity) to structurally related often labile allergens in (plant) foods.		hp.json	IgE-mediated food allergy|Immunoglobulin E-mediated food allergy|Food allergy	http://purl.obolibrary.org/obo/HP_0500093		
GO:0070201	biolink:BiologicalProcess	regulation of establishment of protein localization	Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.		hp.json	regulation of establishment of protein localisation	http://purl.obolibrary.org/obo/GO_0070201		
HP:0500094	biolink:PhenotypicFeature	Latex allergy	Latex allergy is an IgE-mediated immediate hypersensitivity response to natural rubber latex (NRL) protein with a variety of clinical signs ranging from contact urticaria, angioedema, asthma, and anaphylaxis.		hp.json		http://purl.obolibrary.org/obo/HP_0500094		
HP:0500091	biolink:PhenotypicFeature	Lymphangioma of the orbit	A hamartoma of lymph vessels that usually presents in childhood. It tends to increase in size with head-down posture and with the Valsalva manoeuvre. Superficial lesions are visible as transilluminable cystic spaces of the lid or conjunctiva that may also contain blood. Deep lesions may cause gradual proptosis or present acutely with orbital pain and reduced vision due to haemorrhage.		hp.json		http://purl.obolibrary.org/obo/HP_0500091		
UBERON:0003540	biolink:AnatomicalEntity	right lung terminal bronchiole	A terminal bronchiole that is part of a right lung [Automatically generated definition].	UMLS:C1709961|EMAPA:36638|MA:0001789|NCIT:C49294	hp.json	terminal bronchiole of right lung|bronchiolus terminalis of right lung|right lung bronchiolus terminalis	http://purl.obolibrary.org/obo/UBERON_0003540		
UBERON:0003541	biolink:AnatomicalEntity	left lung terminal bronchiole	A terminal bronchiole that is part of a left lung [Automatically generated definition].	MA:0001780|EMAPA:36636|NCIT:C49255|UMLS:C1708675	hp.json	bronchiolus terminalis of left lung|terminal bronchiole of left lung|left lung bronchiolus terminalis	http://purl.obolibrary.org/obo/UBERON_0003541		
HP:0500092	biolink:PhenotypicFeature	Orbital rhabdomyosarcoma	A mesenchymal tumour that is considered to be the commonest primary orbital malignancy in children. Histologically, it may be differentiated into embryonal, alveolar, and pleomorphic types. It is usually intraconal or within the superior orbit.		hp.json		http://purl.obolibrary.org/obo/HP_0500092		
HP:0500075	biolink:PhenotypicFeature	Dissociated horizontal deviation	A change in horizontal ocular alignment, unrelated to accommodation, that is brought about solely by a change in the balance of visual input from the two eyes.		hp.json		http://purl.obolibrary.org/obo/HP_0500075		
UBERON:0015593	biolink:AnatomicalEntity	frontal gyrus	A gyrus that is part of a frontal cortex.	NCIT:C32636	hp.json		http://purl.obolibrary.org/obo/UBERON_0015593		
HP:0500076	biolink:PhenotypicFeature	Alternating hypertropia	A type of vertical tropia in which, when one eye is fixing, the other eye is deviated upwards.		hp.json		http://purl.obolibrary.org/obo/HP_0500076		
GO:0070230	biolink:BiologicalProcess	positive regulation of lymphocyte apoptotic process	Any process that activates or increases the frequency, rate or extent of lymphocyte death by apoptotic process.		hp.json	positive regulation of lymphocyte apoptosis|upregulation of lymphocyte apoptosis|up regulation of lymphocyte apoptosis|stimulation of lymphocyte apoptosis|up-regulation of lymphocyte apoptosis|activation of lymphocyte apoptosis	http://purl.obolibrary.org/obo/GO_0070230		
HP:0500073	biolink:PhenotypicFeature	Abnormal ocular alignment	Any deviation from the normal ocular alignment.		hp.json		http://purl.obolibrary.org/obo/HP_0500073		
HP:0500074	biolink:PhenotypicFeature	Dissociated vertical deviation	An incomitant tendency for an occluded eye to elevate and extort which resolves on uncovering.		hp.json		http://purl.obolibrary.org/obo/HP_0500074		
HP:0500079	biolink:PhenotypicFeature	Alternating hypophoria	A type of vertical phoria in which, in dissociation, the occluded eye deviates downwards.		hp.json		http://purl.obolibrary.org/obo/HP_0500079		
HP:0500077	biolink:PhenotypicFeature	Alternating hyperphoria	A type of vertical phoria in which, in dissociation, the occluded eye deviates upwards.		hp.json		http://purl.obolibrary.org/obo/HP_0500077		
HP:0500078	biolink:PhenotypicFeature	Alternating hypotropia	A type of vertical tropia in which, when one eye is fixing, the other eye is deviated downwards.		hp.json		http://purl.obolibrary.org/obo/HP_0500078		
MPATH:602	biolink:NamedThing	hyperplastic tissue	An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation.		hp.json		http://purl.obolibrary.org/obo/MPATH_602		
GO:0070233	biolink:BiologicalProcess	negative regulation of T cell apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.		hp.json	negative regulation of T cell apoptosis|down regulation of T cell apoptosis|inhibition of T cell apoptosis|down-regulation of T cell apoptosis|negative regulation of programmed cell death of T cells by apoptosis|negative regulation of T-cell apoptosis|negative regulation of T lymphocyte apoptosis|negative regulation of T-lymphocyte apoptosis|downregulation of T cell apoptosis	http://purl.obolibrary.org/obo/GO_0070233		
GO:0070234	biolink:BiologicalProcess	positive regulation of T cell apoptotic process	Any process that activates or increases the frequency, rate or extent of T cell death by apoptotic process.		hp.json	activation of T cell apoptosis|positive regulation of T-lymphocyte apoptosis|positive regulation of programmed cell death of T cells by apoptosis|positive regulation of T cell apoptosis|upregulation of T cell apoptosis|up regulation of T cell apoptosis|stimulation of T cell apoptosis|positive regulation of T-cell apoptosis|positive regulation of T lymphocyte apoptosis|up-regulation of T cell apoptosis	http://purl.obolibrary.org/obo/GO_0070234		
MPATH:603	biolink:NamedThing	pathological anatomical entity	Anatomically located instance of pathological response or entity.		hp.json		http://purl.obolibrary.org/obo/MPATH_603		
GO:0070231	biolink:BiologicalProcess	T cell apoptotic process	Any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.		hp.json	T-cell apoptosis|T lymphocyte apoptosis|programmed cell death of T cells by apoptosis|T-lymphocyte apoptosis|T cell apoptosis	http://purl.obolibrary.org/obo/GO_0070231		
GO:0070232	biolink:BiologicalProcess	regulation of T cell apoptotic process	Any process that modulates the occurrence or rate of T cell death by apoptotic process.		hp.json	regulation of T-cell apoptosis|regulation of T lymphocyte apoptosis|regulation of T-lymphocyte apoptosis|regulation of T cell apoptosis|regulation of programmed cell death of T cells by apoptosis	http://purl.obolibrary.org/obo/GO_0070232		
HP:0500081	biolink:PhenotypicFeature	Pseudophakia	The term pseudophakia refers to having an artificial lens implanted after the natural eye lens has been removed. During cataract surgery the natural cloudy lens is replaced by an pseudophakia intraocular lens (IOL).		hp.json		http://purl.obolibrary.org/obo/HP_0500081		
HP:0500064	biolink:PhenotypicFeature	Retinopathy of prematurity threshold	A retinopathy with a 50% likelihood of progressing to retinal detachment. Threshold disease is considered to be present when stage 3 retinopathy of prematurity (ROP) is present in either zone I or zone II, with at least 5 continuous or 8 total clock hours of disease, and the presence of plus disease.		hp.json	ROP threshold	http://purl.obolibrary.org/obo/HP_0500064		
HP:0500065	biolink:PhenotypicFeature	Retinopathy of prematurity prethreshold	High risk patients who were in Zone 1 (no Plus or stage 3) or Zone 2 with Plus or stage 3 but not both.		hp.json	ROP prethreshold	http://purl.obolibrary.org/obo/HP_0500065		
HP:0500062	biolink:PhenotypicFeature	Retinopathy of prematurity plus	Venous dilatation and arteriolar tortuosity of the posterior retinal vessels and may later increase in severity to include iris vascular engorgement, poor pupillary dilatation (rigid pupil), and vitreous haze. This definition has been further refined in the later clinical trials in which the diagnosis of plus disease could be made if sufficient vascular dilatation and tortuosity are present in at least 2 quadrants of the eye.		hp.json	ROP plus	http://purl.obolibrary.org/obo/HP_0500062		
HP:0500063	biolink:PhenotypicFeature	Retinopathy of prematurity pre-plus	As vascular abnormalities of the posterior pole that are insufficient for the diagnosis of plus disease but that demonstrate more arterial tortuosity and more venous dilatation than normal.		hp.json	ROP pre-plus	http://purl.obolibrary.org/obo/HP_0500063		
HP:0500069	biolink:PhenotypicFeature	Paralytic ectropion	A type of ectropion associated with orbicularis muscle weakness caused by cranial nerve VII palsy.		hp.json		http://purl.obolibrary.org/obo/HP_0500069		
HP:0500066	biolink:PhenotypicFeature	Latent myopia	The difference between total and manifest myopia.		hp.json		http://purl.obolibrary.org/obo/HP_0500066		
CHEBI:10545	biolink:ChemicalSubstance	electron	Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV.	Wikipedia:Electron|PMID:21614077|KEGG:C05359|PMID:21614077	hp.json	e|beta-particle|beta(-)|electron|beta|e(-)|negatron|e-|electron|Elektron|electron	http://purl.obolibrary.org/obo/CHEBI_10545		3_STAR
GO:0070228	biolink:BiologicalProcess	regulation of lymphocyte apoptotic process	Any process that modulates the occurrence or rate of lymphocyte death by apoptotic process.		hp.json	regulation of lymphocyte apoptosis	http://purl.obolibrary.org/obo/GO_0070228		
GO:0070229	biolink:BiologicalProcess	negative regulation of lymphocyte apoptotic process	Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process.		hp.json	downregulation of lymphocyte apoptosis|negative regulation of lymphocyte apoptosis|down regulation of lymphocyte apoptosis|inhibition of lymphocyte apoptosis|down-regulation of lymphocyte apoptosis	http://purl.obolibrary.org/obo/GO_0070229		
GO:0070227	biolink:BiologicalProcess	lymphocyte apoptotic process	Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.		hp.json	lymphocyte apoptosis	http://purl.obolibrary.org/obo/GO_0070227		
CHEBI:22558	biolink:ChemicalSubstance	anhydro sugar	Intramolecular ethers formally arising by elimination of water from two hydroxy groups of a single molecule of a monosaccharide (aldose or ketose) or monosaccharide derivative.		hp.json	anhydrosugars|sugar anhydrides|anhydro sugar|anhydro sugars|sugar anhydride	http://purl.obolibrary.org/obo/CHEBI_22558		3_STAR
HP:0500072	biolink:PhenotypicFeature	Absolute eccentric fixation	Eccentric fixation in which the angle of eccentricity equals the objective angle of deviation.		hp.json		http://purl.obolibrary.org/obo/HP_0500072		
HP:0500070	biolink:PhenotypicFeature	Conjunctival dermolipoma	A conjuctival lesion composed of adipose tissue and dense connective tissue. Such choristomas of dermal elements are normally found at the outer canthus, and have a gelatinous appearance. Classically, there is an indistinct posterior border (with the lesion frequently extending into the orbit) and a well-demarcated anterior border several millimetres posterior to the limbus.		hp.json		http://purl.obolibrary.org/obo/HP_0500070		
HP:0500053	biolink:PhenotypicFeature	Retinopathy of prematurity stage 4	Scar tissue that forms a continuous sheet coming up from the edge of the vascularized retina. This scar tissue can grow toward the vitreous base/posterior lens capsule resulting in traction, distortion, and even detachment.		hp.json	ROP stage 4	http://purl.obolibrary.org/obo/HP_0500053		
GO:0045296	biolink:MolecularActivity	cadherin binding	Binding to cadherin, a type I membrane protein involved in cell adhesion.		hp.json		http://purl.obolibrary.org/obo/GO_0045296		
HP:0500054	biolink:PhenotypicFeature	Retinopathy of prematurity stage 4a	A detachment that involves the peripheral retina that does not extend into the macula.		hp.json	ROP stage 4a	http://purl.obolibrary.org/obo/HP_0500054		
HP:0500051	biolink:PhenotypicFeature	Retinopathy of prematurity stage 2	The accumulating neovascularization thickens and manifests as a linear bump. The neovascularization remains along the surface of the retina and does not extend off the retina into the cortical vitreous.		hp.json	ROP stage 2	http://purl.obolibrary.org/obo/HP_0500051		
HP:0500052	biolink:PhenotypicFeature	Retinopathy of prematurity stage 3	The neovascularization accumulates at the edge of the vascularized retina and extends into the vitreous (also called extra retinal fibrosis proliferation). In cases of Zone 2 and Zone 3, this may be sausage shaped. In more posterior Zone 1 disease, the stage 3 can appear as a direct extension of the normal retinal vessels but extending tangentially over the avascular retina.		hp.json	ROP stage 3	http://purl.obolibrary.org/obo/HP_0500052		
HP:0500057	biolink:PhenotypicFeature	Retinopathy of prematurity stage 5a	An open funnel detachment of the retina with generally traction in all four quadrants.		hp.json	ROP stage 5a	http://purl.obolibrary.org/obo/HP_0500057		
HP:0500058	biolink:PhenotypicFeature	Retinopathy of prematurity stage 5b	A closed funnel detachment of the retina with generally traction in all four quadrants.		hp.json	ROP stage 5b	http://purl.obolibrary.org/obo/HP_0500058		
HP:0500055	biolink:PhenotypicFeature	Retinopathy of prematurity stage 4b	A detachment that involves the peripheral retina that involves the macula itself. The detachment usually starts in the temporal periphery although can also involve the nasal retina as well.		hp.json	ROP 4b	http://purl.obolibrary.org/obo/HP_0500055		
HP:0500056	biolink:PhenotypicFeature	Retinopathy of prematurity stage 5	Funnel detachment from the retina with generally traction in all four quadrants.		hp.json	ROP stage 5	http://purl.obolibrary.org/obo/HP_0500056		
HP:0500059	biolink:PhenotypicFeature	Retinopathy of prematurity zone I	Retinopathy which extends from the center of the optic disc to twice the distance from the center of the optic disc to the center of the macula.		hp.json	ROP zone 1	http://purl.obolibrary.org/obo/HP_0500059		
CHEBI:356416	biolink:ChemicalSubstance	5-ammoniolevulinate	The zwitterion formed from 5-aminolevulinic acid by transfer of a proton from the carboxy group to the amino group.  It is the major species present at physiological pH.	PMID:14667225	hp.json	5-azaniumyl-4-oxopentanoate|5-ammonio-4-oxovalerate|5-aminolevulinate|5-ammonio-4-oxopentanoate	http://purl.obolibrary.org/obo/CHEBI_356416		3_STAR
UBERON:0003593	biolink:AnatomicalEntity	thoracic cavity connective tissue	A portion of connective tissue that is part of a thoracic cavity [Automatically generated definition].	EMAPA:37255|MA:0000555	hp.json	textus connectivus of cavity of thorax|pectoral cavity portion of connective tissue|connective tissue of chest cavity|portion of connective tissue of chest cavity|cavity of chest portion of connective tissue|cavity of thorax connective tissue|thoracic cavity portion of connective tissue|cavity of thorax textus connectivus|connective tissue of thoracic cavity|portion of connective tissue of thoracic cavity|connective tissue of pectoral cavity|portion of connective tissue of cavity of chest|portion of connective tissue of pectoral cavity|chest cavity portion of connective tissue|connective tissue of cavity of chest|cavity of chest textus connectivus|textus connectivus of chest cavity|pectoral cavity textus connectivus|thoracic cavity textus connectivus|connective tissue of cavity of thorax|portion of connective tissue of cavity of thorax|chest cavity connective tissue|chest cavity textus connectivus|cavity of thorax portion of connective tissue|textus connectivus of thoracic cavity|pectoral cavity connective tissue|textus connectivus of cavity of chest|cavity of chest connective tissue|textus connectivus of pectoral cavity	http://purl.obolibrary.org/obo/UBERON_0003593		
UBERON:0003594	biolink:AnatomicalEntity	pelvis connective tissue	A portion of connective tissue that is part of a pelvis [Automatically generated definition].	EMAPA:37257|MA:0000533	hp.json	pelvis textus connectivus|textus connectivus of pelvis|pelvis portion of connective tissue|portion of connective tissue of pelvis|connective tissue of pelvis	http://purl.obolibrary.org/obo/UBERON_0003594		
UBERON:0003592	biolink:AnatomicalEntity	bronchus connective tissue	A portion of connective tissue that is part of a bronchus [Automatically generated definition].	NCIT:C49210|MA:0001831|EMAPA:32690|UMLS:C1707052|EMAPA:35193	hp.json	bronchial mesenchyme|portion of connective tissue of bronchi|connective tissue of bronchi|bronchus portion of connective tissue|connective tissue of bronchial trunk|portion of connective tissue of bronchial trunk|bronchial trunk portion of connective tissue|connective tissue of bronchus|bronchi portion of connective tissue|portion of connective tissue of bronchus|bronchus textus connectivus|textus connectivus of bronchi|bronchial trunk textus connectivus|bronchi connective tissue|textus connectivus of bronchus|bronchi textus connectivus|bronchial trunk connective tissue|textus connectivus of bronchial trunk|bronchial connective tissue	http://purl.obolibrary.org/obo/UBERON_0003592		
CHEBI:22527	biolink:ChemicalSubstance	aminopurine	Any purine having at least one amino substituent.		hp.json	aminopurines	http://purl.obolibrary.org/obo/CHEBI_22527		3_STAR
UBERON:0003599	biolink:AnatomicalEntity	tail connective tissue	A portion of connective tissue that is part of a tail [Automatically generated definition].	EMAPA:16749|MA:0000697	hp.json	textus connectivus of tail|post-vent region connective tissue|tail portion of connective tissue|post-vent region portion of connective tissue|portion of connective tissue of post-vent region|connective tissue of post-vent region|tail textus connectivus|connective tissue of tail|portion of connective tissue of tail|post-vent region textus connectivus|textus connectivus of post-vent region	http://purl.obolibrary.org/obo/UBERON_0003599		
GO:0070257	biolink:BiologicalProcess	positive regulation of mucus secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.		hp.json	positive regulation of mucus production	http://purl.obolibrary.org/obo/GO_0070257		
UBERON:0003597	biolink:AnatomicalEntity	manual digit connective tissue	A portion of connective tissue that is part of a finger [Automatically generated definition].	EMAPA:37321|MA:0000623	hp.json	connective tissue of finger|connective tissue of digit of hand|connective tissue of digitus manus|hand digit connective tissue|hand digit connective tissue|connective tissue of hand digit|fore limb digit connective tissue	http://purl.obolibrary.org/obo/UBERON_0003597		
GO:0070255	biolink:BiologicalProcess	regulation of mucus secretion	Any process that modulates the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.		hp.json	regulation of mucus production	http://purl.obolibrary.org/obo/GO_0070255		
HP:0500060	biolink:PhenotypicFeature	Retinopathy of prematurity zone II	Retinopathy which extends centrifugally from the edge of zone I to the nasal ora serrata.		hp.json	ROP zone II	http://purl.obolibrary.org/obo/HP_0500060		
UBERON:0003598	biolink:AnatomicalEntity	manus connective tissue	A portion of connective tissue that is part of a hand [Automatically generated definition].	MA:0000620|EMAPA:35392	hp.json	hand connective tissue|connective tissue of hand|connective tissue of terminal segment of free upper limb	http://purl.obolibrary.org/obo/UBERON_0003598		
GO:0070256	biolink:BiologicalProcess	negative regulation of mucus secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of mucus from a cell or a tissue.		hp.json	negative regulation of mucus production	http://purl.obolibrary.org/obo/GO_0070256		
HP:0500061	biolink:PhenotypicFeature	Retinopathy of prematurity zone III	Retinopathy which is a residual crescent of retina anterior to zone II.		hp.json	ROP zone III	http://purl.obolibrary.org/obo/HP_0500061		
GO:0070253	biolink:BiologicalProcess	somatostatin secretion	The regulated release of somatostatin from secretory granules in the D cells of the pancreas.		hp.json		http://purl.obolibrary.org/obo/GO_0070253		
UBERON:0003595	biolink:AnatomicalEntity	pes connective tissue	A portion of connective tissue that is part of a foot [Automatically generated definition].	MA:0000644|EMAPA:37329	hp.json	foot connective tissue|textus connectivus of pes|connective tissue of foot|connective tissue of terminal segment of free lower limb	http://purl.obolibrary.org/obo/UBERON_0003595		
GO:0070254	biolink:BiologicalProcess	mucus secretion	The regulated release of mucus by the mucosa. Mucus is a viscous slimy secretion consisting of mucins and various inorganic salts dissolved in water, with suspended epithelial cells and leukocytes. The mucosa, or mucous membrane, is the membrane covered with epithelium that lines the tubular organs of the body. Mucins are carbohydrate-rich glycoproteins that have a lubricating and protective function.		hp.json	mucus production	http://purl.obolibrary.org/obo/GO_0070254		
UBERON:0003596	biolink:AnatomicalEntity	ankle connective tissue	A portion of connective tissue that is part of an ankle [Automatically generated definition].	MA:0000639|EMAPA:37328	hp.json	connective tissue of ankle|tarsal region connective tissue	http://purl.obolibrary.org/obo/UBERON_0003596		
HP:0500042	biolink:PhenotypicFeature	Latent hypermetropia	A term to describe when farsightedness is masked when the accommodative muscles are used to increase the focusing power of the eye.		hp.json	Latent hyperopia	http://purl.obolibrary.org/obo/HP_0500042		
HP:0500043	biolink:PhenotypicFeature	Eyelid retraction	With the eyes in primary position, the sclera is visible above the superior corneal limbus.		hp.json		http://purl.obolibrary.org/obo/HP_0500043		
HP:0500040	biolink:PhenotypicFeature	Dermolipoma of the conjunctiva	A benign tumor composed of adipose tissue and dense connective tissue usually located near the temporal fornix.		hp.json	Conjunctival lipodermoid	http://purl.obolibrary.org/obo/HP_0500040		
HP:0500041	biolink:PhenotypicFeature	Myopic astigmatism	A condition where one or both of the two principal meridians focus in the front of the retina when the eye is at rest.		hp.json		http://purl.obolibrary.org/obo/HP_0500041		
HP:0500046	biolink:PhenotypicFeature	Seborrhoeic blepharitis	Inflamation of the eyelid due to overactivity of the sebaceous gland.		hp.json		http://purl.obolibrary.org/obo/HP_0500046		
HP:0500047	biolink:PhenotypicFeature	Nasolacrimal sac lymphoma	A type of lymphoma that involves the nasolacrimal sac.		hp.json		http://purl.obolibrary.org/obo/HP_0500047		
HP:0500044	biolink:PhenotypicFeature	Upper eyelid retraction	An elevation of the eyelid above the normal level in the primary position.		hp.json		http://purl.obolibrary.org/obo/HP_0500044		
HP:0500045	biolink:PhenotypicFeature	Collier's sign	A unilateral or bilateral eyelid retraction due to midbrain lesions.		hp.json		http://purl.obolibrary.org/obo/HP_0500045		
HP:0500048	biolink:PhenotypicFeature	Delayed canalization of nasolacrimal duct	A very common condition in which the extreme end of the nasolacrimal duct underneath the inferior turbinate fails to complete its canalization in the newborn period.		hp.json		http://purl.obolibrary.org/obo/HP_0500048		
HP:0500049	biolink:PhenotypicFeature	Retinopathy of prematurity	An avascular or abnormally vascularized retina that occurs in premature infants and can lead to blindness.		hp.json		http://purl.obolibrary.org/obo/HP_0500049		
UBERON:0003582	biolink:AnatomicalEntity	nasopharynx connective tissue	A portion of connective tissue that is part of a nasopharynx [Automatically generated definition].	EMAPA:37682|MA:0001864	hp.json	nasal part of pharynx textus connectivus|connective tissue of rhinopharynx|portion of connective tissue of rhinopharynx|nasopharynx textus connectivus|textus connectivus of nasopharynx|rhinopharynx portion of connective tissue|textus connectivus of nasal part of pharynx|nasal part of pharynx connective tissue|textus connectivus of rhinopharynx|nasal part of pharynx portion of connective tissue|rhinopharynx connective tissue|nasopharynx portion of connective tissue|portion of connective tissue of nasopharynx|connective tissue of nasopharynx|rhinopharynx textus connectivus|connective tissue of nasal part of pharynx|portion of connective tissue of nasal part of pharynx	http://purl.obolibrary.org/obo/UBERON_0003582		
UBERON:0003583	biolink:AnatomicalEntity	larynx connective tissue	A portion of connective tissue that is part of a larynx [Automatically generated definition].	NCIT:C49245|MA:0001754|UMLS:C1708651|EMAPA:35471	hp.json	portion of connective tissue of larynx|connective tissue of larynx|laryngeal connective tissue|larynx portion of connective tissue|textus connectivus of larynx|larynx textus connectivus	http://purl.obolibrary.org/obo/UBERON_0003583		
UBERON:0003580	biolink:AnatomicalEntity	lower respiratory tract connective tissue	A portion of connective tissue that is part of a lower respiratory tract [Automatically generated definition].	MA:0002409|EMAPA:37548	hp.json	textus connectivus of lower respiratory tract|lower respiratory tract textus connectivus|connective tissue of lower respiratory tract|portion of connective tissue of lower respiratory tract|lower respiratory tract portion of connective tissue	http://purl.obolibrary.org/obo/UBERON_0003580		
UBERON:0003581	biolink:AnatomicalEntity	eyelid connective tissue	A portion of connective tissue that is part of a eyelid [Automatically generated definition].	MA:0001251|EMAPA:37532|UMLS:C1707989|NCIT:C49482	hp.json	connective tissue of eyelid|connective tissue of blepharon|blepharon connective tissue	http://purl.obolibrary.org/obo/UBERON_0003581		
NCBITaxon:9347	biolink:OrganismalEntity	Eutheria		GC_ID:1	hp.json	placentals|placental mammals|placentals|eutherian mammals|Placentalia	http://purl.obolibrary.org/obo/NCBITaxon_9347		
UBERON:0003588	biolink:AnatomicalEntity	forelimb connective tissue	A portion of connective tissue that is part of a forelimb [Automatically generated definition].	EMAPA:37314|MA:0000613	hp.json	connective tissue of superior member|wing connective tissue|connective tissue of upper extremity|connective tissue of anteriormost limb|connective tissue of fore limb|connective tissue of forelimb	http://purl.obolibrary.org/obo/UBERON_0003588		
UBERON:0003589	biolink:AnatomicalEntity	hindlimb connective tissue	A portion of connective tissue that is part of a hindlimb [Automatically generated definition].	MA:0000661|EMAPA:37322	hp.json	connective tissue of hind limb|connective tissue of hindlimb|connective tissue of lower extremity|hind limb connective tissue|connective tissue of inferior member	http://purl.obolibrary.org/obo/UBERON_0003589		
UBERON:0003586	biolink:AnatomicalEntity	trunk connective tissue	A portion of connective tissue that is part of a trunk [Automatically generated definition].	EMAPA:37252|MA:0000513	hp.json	textus connectivus of torso|torso connective tissue|connective tissue of trunk|torso portion of connective tissue|portion of connective tissue of trunk|trunk portion of connective tissue|connective tissue of torso|portion of connective tissue of torso|torso textus connectivus|trunk textus connectivus|textus connectivus of trunk	http://purl.obolibrary.org/obo/UBERON_0003586		
UBERON:0003587	biolink:AnatomicalEntity	limb connective tissue	A portion of connective tissue that is part of a limb [Automatically generated definition].	EMAPA:37313|MA:0000689	hp.json	limb portion of connective tissue|portion of connective tissue of limb|connective tissue of limb|limb textus connectivus|textus connectivus of limb	http://purl.obolibrary.org/obo/UBERON_0003587		
HP:0500050	biolink:PhenotypicFeature	Retinopathy of prematurity stage 1	The retinal vessels stop and then a linear flat white line is present that usually runs the circumference of the vascular retina.		hp.json	ROP stage 1	http://purl.obolibrary.org/obo/HP_0500050		
UBERON:0003584	biolink:AnatomicalEntity	mammary gland connective tissue	The fibrous supportive tissue of the mammary gland.	EMAPA:35537|FMA:74483|MA:0002897|FMA:74479	hp.json	lactiferous gland portion of connective tissue|connective tissue of lobe of mammary gland|connective tissue of mammary gland|lactiferous gland connective tissue|stroma of lactiferous gland|lactiferous gland stroma|connective tissue of lactiferous gland|mammary stroma|mammary gland stroma|connective tissue of lobe of breast	http://purl.obolibrary.org/obo/UBERON_0003584		pheno_slim
UBERON:0003585	biolink:AnatomicalEntity	dermis connective tissue	A portion of connective tissue that is part of a dermis [Automatically generated definition].	MA:0000799|EMAPA:36509	hp.json	dermis textus connectivus|connective tissue of dermis|portion of connective tissue of dermis|dermis portion of connective tissue|textus connectivus of dermis	http://purl.obolibrary.org/obo/UBERON_0003585		pheno_slim
UBERON:0003609	biolink:AnatomicalEntity	aorta elastic tissue	The dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall.	MA:0002859	hp.json	textus connectivus elasticus of adult aorta|aorta elastic connective tissue|elastic connective tissue of dorsal aorta|trunk of aortic tree textus connectivus elasticus|elastic connective tissue of trunk of aortic tree|elastic connective tissue of aorta|aorta elastic lamina|dorsal aorta textus connectivus elasticus|aorta elastic laminae|trunk of aortic tree elastic tissue|dorsal aorta elastic tissue|adult aorta textus connectivus elasticus|elastic tissue of aorta|adult aorta elastic connective tissue|elastic connective tissue of adult aorta|adult aorta elastic tissue|textus connectivus elasticus of aorta|dorsal aorta elastic connective tissue|textus connectivus elasticus of dorsal aorta|textus connectivus elasticus of trunk of aortic tree|trunk of aortic tree elastic connective tissue|aorta textus connectivus elasticus|elastic tissue of adult aorta|elastic tissue of dorsal aorta|elastic tissue of trunk of aortic tree	http://purl.obolibrary.org/obo/UBERON_0003609		pheno_slim
HP:0500273	biolink:PhenotypicFeature	Increased proportion of immature gamma-delta T cells	Increased proportion of immature gamma-delta T cells relative to the total number of T cells.		hp.json	Increased proportion of immature gamma-delat T lymphocytes|Elevated proportion of immature gamma-delta T cells|Increased proportion of immature gamma-delta T-lymphocytes|Increased proportion of immature gamma-delta T-cells	http://purl.obolibrary.org/obo/HP_0500273		
HP:0500274	biolink:PhenotypicFeature	Decreased proportion of immature gamma-delta T cells	Decreased proportion of immature gamma-delta T cells relative to the total number of T cells.		hp.json	Reduced proportion of immature gamma-delta T cells|Decreased proportion of immature gamma-delta T-lymphocytes|Decreased proportion of immature gamma-delta T lymphocytes|Decreased proportion of immature gamma-delta T-cells	http://purl.obolibrary.org/obo/HP_0500274		
UBERON:0003607	biolink:AnatomicalEntity	forelimb long bone	A long bone that is part of a forelimb [Automatically generated definition].	MA:0000299|EMAPA:35350	hp.json	long bone of forelimb|upper extremity long bone|anteriormost limb long bone|fore limb long bone|wing long bone|long bone of superior member|long bone of anteriormost limb|long bone of upper extremity|long bone of fore limb|superior member long bone	http://purl.obolibrary.org/obo/UBERON_0003607		
HP:0500271	biolink:PhenotypicFeature	Decreased proportion of gamma-delta T cells	Decreased proportion of gamma-delta T cells relative to the total number of T cells.		hp.json	Decreased proportion of gamma-delta T-cells|Decreased proportion of gammadelta T cells|Reduced proportion of gamma-delta T cells|Decreased proportion of gamma-delta T-lymphocytes|Decreased proportion of gamma-delta T lymphocytes	http://purl.obolibrary.org/obo/HP_0500271		
UBERON:0003608	biolink:AnatomicalEntity	hindlimb long bone	A long bone that is part of a hindlimb [Automatically generated definition].	MA:0000300|EMAPA:35403	hp.json	lower extremity long bone|long bone of inferior member|long bone of hind limb|long bone of hindlimb|long bone of lower extremity|inferior member long bone|hind limb long bone	http://purl.obolibrary.org/obo/UBERON_0003608		
HP:0500272	biolink:PhenotypicFeature	Abnormal proportion of immature gamma-delta T cells	Abnormal proportion of immature gamma-delta T cells relative to the total number of T cells.		hp.json	Abnormal proportion of immature gamma-delta T-lymphocytes|Abnormal proportion of immature gamma-delta T lymphocytes|Abnormal proportion of immature gamma-delta T-cells	http://purl.obolibrary.org/obo/HP_0500272		
UBERON:0003605	biolink:AnatomicalEntity	eye skin gland	A skin gland that is part of a camera-type eye [Automatically generated definition].	MA:0002451|EMAPA:37530	hp.json	skin glands set of vertebrate eye|camera-type eye skin gland|skin glands of vertebrate eye|skin gland of camera-type eye|camera-type eye skin glands set|skin gland of vertebrate eye|camera-type eye skin glands|skin glands of camera-type eye|vertebrate eye skin glands set|skin glands set of camera-type eye|vertebrate eye skin glands|vertebrate eye skin gland	http://purl.obolibrary.org/obo/UBERON_0003605		organ_slim
UBERON:0003606	biolink:AnatomicalEntity	limb long bone	A long bone that is part of a limb [Automatically generated definition].	MA:0000298|EMAPA:35495	hp.json	long bone of limb	http://purl.obolibrary.org/obo/UBERON_0003606		pheno_slim
UBERON:0003603	biolink:AnatomicalEntity	lower respiratory tract cartilage	A cartilage that is part of a lower respiratory tract [Automatically generated definition].	UMLS:C1708759|EMAPA:37547|MA:0001819|NCIT:C49256	hp.json	cartilage of lower respiratory tract	http://purl.obolibrary.org/obo/UBERON_0003603		
UBERON:0003604	biolink:AnatomicalEntity	trachea cartilage	The ring-shaped cartilaginous structures that support the trachea.	UMLS:C1710456|NCIT:C49304|EMAPA:35875|MA:0001857|EMAPA:18699|FMA:7434	hp.json	cartilaginous ring of trachea|tracheal ring|cartilage of windpipe|tracheal cartilage|trachea ring|cartilage of the trachea|windpipe cartilage|ring of the trachea|cartilaginous trachea cartilage|cartilago trachealis|cartilage of trachea|cartilagines tracheales	http://purl.obolibrary.org/obo/UBERON_0003604		pheno_slim|human_reference_atlas
UBERON:0003613	biolink:AnatomicalEntity	cardiovascular system elastic tissue	An elastic tissue that is part of a circulatory system [Automatically generated definition].	MA:0002857	hp.json	textus connectivus elasticus of cardiovascular system|circulatory system textus connectivus elasticus|circulatory system elastic tissue|circulatory system elastic connective tissue|textus connectivus elasticus of circulatory system|elastic tissue of circulatory system|cardiovascular system elastic connective tissue|elastic connective tissue of cardiovascular system|elastic connective tissue of circulatory system|elastic tissue of cardiovascular system|cardiovascular system textus connectivus elasticus	http://purl.obolibrary.org/obo/UBERON_0003613		
UBERON:0003610	biolink:AnatomicalEntity	heart elastic tissue	The type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers.	MA:0002858	hp.json	heart elastic connective tissue|cardiac elastic tissue|elastic connective tissue of heart|heart textus connectivus elasticus|elastic tissue of heart|textus connectivus elasticus of heart	http://purl.obolibrary.org/obo/UBERON_0003610		pheno_slim
UBERON:0003611	biolink:AnatomicalEntity	respiratory system elastic tissue	An elastic tissue that is part of a respiratory system [Automatically generated definition].	EMAPA:37579|MA:0001820	hp.json	elastic connective tissue of respiratory system|apparatus respiratorius textus connectivus elasticus|apparatus respiratorius elastic connective tissue|elastic connective tissue of apparatus respiratorius|apparatus respiratorius elastic tissue|elastic tissue of apparatus respiratorius|respiratory system elastic connective tissue|textus connectivus elasticus of respiratory system|textus connectivus elasticus of apparatus respiratorius|respiratory system textus connectivus elasticus|elastic tissue of respiratory system	http://purl.obolibrary.org/obo/UBERON_0003611		
CHEBI:138103	biolink:ChemicalSubstance	inorganic acid	A Bronsted acid derived from one or more inorganic compounds. Inorganic acids (also known as mineral acids) form hydrons and conjugate base ions when dissolved in water.	Wikipedia:Mineral_acid	hp.json	mineral acid|mineral acids|inorganic acids	http://purl.obolibrary.org/obo/CHEBI_138103		3_STAR
HP:0500262	biolink:PhenotypicFeature	Atrichia	The most dramatic and severe form of hair loss characterized by an absence of hair follicles.		hp.json		http://purl.obolibrary.org/obo/HP_0500262		
HP:0500263	biolink:PhenotypicFeature	Abnormal helper T cell proportion	Abnormal proportion of helper T cells relative to the total number of T cells.		hp.json	Abnormal proportion of circulating T-helper cells	http://purl.obolibrary.org/obo/HP_0500263		
HP:0500260	biolink:PhenotypicFeature	Triggered by head trauma	Applies to a sign or symptom that is provoked or brought about by exposure to a head trauma.		hp.json	Head trauma triggered symptoms	http://purl.obolibrary.org/obo/HP_0500260		
HP:0500261	biolink:PhenotypicFeature	Triggered by anesthetics	Applies to a sign or symptom that is provoked or brought about by exposure to anesthetics.		hp.json	Anaesthetics triggered symptoms|Anaesthetics trigger episodes|Anesthetics triggered symptoms|Anesthetics trigger episodes|Triggered by anaesthetics	http://purl.obolibrary.org/obo/HP_0500261		
HP:0500266	biolink:PhenotypicFeature	Decreased proportion of CD8-positive, alpha-beta TEMRA T cells	An decreased proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative.		hp.json	Decreased proportion effector memory CD8-positive, alpha-beta T cells, terminally differentiated	http://purl.obolibrary.org/obo/HP_0500266		
HP:0500267	biolink:PhenotypicFeature	Abnormal proportion of CD4-positive helper T cells	An abnormal proportion of circulating CD4-positive helper T cells relative to total T cell count.		hp.json		http://purl.obolibrary.org/obo/HP_0500267		
HP:0500264	biolink:PhenotypicFeature	Increased helper T cell proportion	Increased proportion of helper T cells relative to the total number of T cells.		hp.json	Elevated helper T cell proportion|Increased proportion T-helper cells	http://purl.obolibrary.org/obo/HP_0500264		
HP:0500265	biolink:PhenotypicFeature	Increased proportion of CD8-positive, alpha-beta TEMRA T cells	An increased proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative.		hp.json	Increased proportion of effector memory CD8-positive, alpha-beta T cells, terminally differentiated	http://purl.obolibrary.org/obo/HP_0500265		
HP:0500269	biolink:PhenotypicFeature	Abnormal proportion of gamma-delta T cells	Abnormal proportion of gamma-delta T cells relative to the total number of T cells.		hp.json	Abnormal proportion of gamma-delta T-lymphocytes|Abnormal proportion of gammadelta T cells|Abnormal proprotion of gamma-delta T lymphocytes	http://purl.obolibrary.org/obo/HP_0500269		
UBERON:0003601	biolink:AnatomicalEntity	neck cartilage	A cartilage that is part of a neck [Automatically generated definition].	EMAPA:37251|MA:0000586	hp.json	neck (volume) cartilage|cartilage of neck|cartilage of neck (volume)	http://purl.obolibrary.org/obo/UBERON_0003601		
HP:0500270	biolink:PhenotypicFeature	Increased proportion of gamma-delta T cells	Increased proportion of gamma-delta T cells relative to the total number of T cells.		hp.json	Increased proportion of gamma-delta T-lymphocytes|Increased proportion of gamma-delta T lymphocytes|Increased proportion of gamma-delta T-cells|Increased proportion of gammadelta T cells|Elevated proportion of gamma-delta T cells	http://purl.obolibrary.org/obo/HP_0500270		
HP:0500251	biolink:PhenotypicFeature	Abnormal urine sebacic acid concentration	Abnormal concentration of sebacic acid in the urine.		hp.json	Abnormal urine decanedioic acid concentration	http://purl.obolibrary.org/obo/HP_0500251		
HP:0500252	biolink:PhenotypicFeature	Increased urine sebacic acid concentration	Elevated concentration of sebacic acid in the urine.		hp.json	Increased urine decanedioic acid concentration	http://purl.obolibrary.org/obo/HP_0500252		
HP:0500250	biolink:PhenotypicFeature	Increased circulating ethanolamine concentration	Abnormally increased levels of ethanolamine in circulation.		hp.json	High ethanolamine levels in the blood	http://purl.obolibrary.org/obo/HP_0500250		
HP:0500255	biolink:PhenotypicFeature	Increased level of hexanoylglycine in urine	Elevated concentration of hexanoylglycine in the urine.		hp.json	Elevated urinary N-hexanoylglycine concentration	http://purl.obolibrary.org/obo/HP_0500255		
HP:0500256	biolink:PhenotypicFeature	Abnormal urine isobutyrylglycine concentration	Abnormal concentration of isobutyrylglycine in the urine.		hp.json	Abnormal urinary isobutyrylglycine levels	http://purl.obolibrary.org/obo/HP_0500256		
HP:0500253	biolink:PhenotypicFeature	Increased level of gamma-aminobutyric acid in urine	Elevated concentration of gamma-aminobutyric acid in the urine.		hp.json	Increased urinary excretion of gamma-aminobutyric acid (GABA)	http://purl.obolibrary.org/obo/HP_0500253		
HP:0500254	biolink:PhenotypicFeature	Abnormal urine hexanoylglycine concentration	Abnormal concentration of hexanoylglycine in the urine.		hp.json	Abnormal urinary N-hexanoylglycine levels	http://purl.obolibrary.org/obo/HP_0500254		
HP:0500259	biolink:PhenotypicFeature	Abnormal oxygen level in cord blood	An abnormal level of blood oxygen in the cord blood.		hp.json	Abnormal oxygen amount in umbilical cord blood|Abnormal cord blood oxygen levels|Abnormal O2 level in cord blood	http://purl.obolibrary.org/obo/HP_0500259		
HP:0500257	biolink:PhenotypicFeature	Increased urine isobutyrylglycine concentration	Elevated concentration of isobutyrylglycine in the urine.		hp.json	High urinary isobutyrylglycine levels	http://purl.obolibrary.org/obo/HP_0500257		
HP:0500258	biolink:PhenotypicFeature	Abnormal carbon dioxide level in cord blood	Abnormal amount of carbon dioxide in umbilical cord blood		hp.json	Abnormal umbilical cord blood levels of carbon dioxide|Abnormal CO2 level in cord blood	http://purl.obolibrary.org/obo/HP_0500258		
PR:000009771	biolink:Protein	galectin-3	A protein that is a translation product of the human LGALS3 gene or a 1:1 ortholog thereof.		hp.json	LGALS3|35 kDa lectin|carbohydrate-binding protein 35|galactose-specific lectin 3|IgE-binding protein|Mac-2 antigen|CBP 35|galactoside-binding protein|GALBP|L-31|L-34 galactoside-binding lectin|laminin-binding protein|lectin L-29|MAC2|gal-3	http://purl.obolibrary.org/obo/PR_000009771		
HP:0500240	biolink:PhenotypicFeature	Abnormal CSF carnosine concentration	Any deviation from the normal concentration of carnosine in the cerebrospinal fluid.		hp.json	Abnormal carnosine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500240		
HP:0500241	biolink:PhenotypicFeature	Abnormal CSF homocarnosine concentration	Any deviation from the normal concentration of homocarnosine in the cerebrospinal fluid.		hp.json	Abnormal homocarnosine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500241		
HP:0500244	biolink:PhenotypicFeature	Increased CSF ornithine concentration	Abnormally increased levels of ornithine in cerebrospinal fluid.		hp.json	High ornithine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500244		
HP:0500245	biolink:PhenotypicFeature	Abnormal CSF citrulline concentration	Any deviation from the normal concentration of citrulline in the cerebrospinal fluid.		hp.json	Abnormal citrulline levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500245		
HP:0500242	biolink:PhenotypicFeature	Increased CSF homocarnosine concentration	Abnormally increased levels of homocarnosine in cerebrospinal fluid.		hp.json	High homocarnosine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500242		
HP:0500243	biolink:PhenotypicFeature	Abnormal CSF ornithine concentration	Any deviation from the normal concentration of ornithine in the cerebrospinal fluid.		hp.json	Abnormal ornithine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500243		
HP:0500248	biolink:PhenotypicFeature	Increased CSF alpha-aminobutyrate concentration	Abnormally increased levels of alpha-aminobutyrate in cerebrospinal fluid.		hp.json	High alpha-aminobutyrate levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500248		
HP:0500249	biolink:PhenotypicFeature	Abnormal circulating ethanolamine concentration	Any deviation from the normal concentration of ethanolamine in circulation.		hp.json	Abnormal ethanolamine levels in the blood	http://purl.obolibrary.org/obo/HP_0500249		
HP:0500246	biolink:PhenotypicFeature	Increased CSF citrulline concentration	Abnormally increased levels of citrulline in cerebrospinal fluid.		hp.json	High citrulline levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500246		
HP:0500247	biolink:PhenotypicFeature	Abnormal CSF alpha-aminobutyrate concentration	Any deviation from the normal concentration of alpha-aminobutyrate in the cerebrospinal fluid.		hp.json	Abnormal alpha-aminobutyrate levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500247		
CHEBI:58465	biolink:ChemicalSubstance	dermatan sulfate polyanion	The conjugate base of dermatan sulfate, obtained by deprotonation of carboxy and sulfate groups.		hp.json	dermatan 4'-sulfate	http://purl.obolibrary.org/obo/CHEBI_58465		3_STAR
HP:0500230	biolink:PhenotypicFeature	Increased CSF glycine concentration	Abnormally increased levels of glycine in cerebrospinal fluid.		hp.json	High glycine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500230		
UBERON:0003649	biolink:AnatomicalEntity	metacarpal bone of digit 5	A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 5.	EMAPA:19120|UMLS:C1711224|MA:0001368|AAO:0000855|FMA:23903|NCIT:C52792	hp.json	5 th digit of hand metacarpal|metacarpal of fifth finger|manual digit 5 metacarpus|metacarpal of hand digit 5|metacarpal bone of 5 th digit of hand|metacarpal of 5 th finger|fifth metacarpal bone|forelimb digit 5 metacarpus|metacarpal bone of fifth finger|5 th finger metacarpal|5 th finger metacarpal bone|metacarpal bone of hand digit 5|metacarpal V|metacarpal 5|finger 5 metacarpus|metacarpal bone of digit V|metacarpal bone digit 5|5 th digit of hand metacarpal bone|hand digit 5 metacarpal|fifth finger metacarpal|fifth finger metacarpal bone|metacarpal of 5 th digit of hand|hand digit 5 metacarpal bone|metacarpal bone of 5 th finger	http://purl.obolibrary.org/obo/UBERON_0003649		pheno_slim
GO:0008406	biolink:BiologicalProcess	gonad development	The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.		hp.json	gonadogenesis	http://purl.obolibrary.org/obo/GO_0008406		
HP:0500233	biolink:PhenotypicFeature	Increased CSF alanine concentration	Abnormally increased levels of alanine in cerebrospinal fluid.		hp.json	High alanine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500233		
HP:0500234	biolink:PhenotypicFeature	Decreased CSF alanine concentration	Abnormally decreased levels of alanine in cerebrospinal fluid.		hp.json	Low alanine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500234		
HP:0500231	biolink:PhenotypicFeature	Abnormal CSF pyruvate family amino acid concentration	Any deviation from the normal concentration of pyruvate-family amino acids in the cerebrospinal fluid.		hp.json	Abnormal pyruvate-family amino acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500231		
UBERON:0003647	biolink:AnatomicalEntity	metacarpal bone of digit 3	A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 3[Automatically generated definition].	UMLS:C1708989|EMAPA:19116|MA:0001366|AAO:0000854|NCIT:C52794|FMA:23901	hp.json	third metacarpal bone|metacarpal of third finger|hand digit 3 metacarpal bone|metacarpal bone of 3 rd digit of hand|metacarpal of 3 rd finger|metacarpal of hand digit 3|metacarpal bone of third finger|forelimb cannon bone|3 rd finger metacarpal bone|3 rd finger metacarpal|finger 3 metacarpus|metacarpal bone of digit III|metacarpal bone of hand digit 3|forelimb digit 3 metacarpus|metacarpal 3|metacarpal bone digit 3|hand digit 3 metacarpal|metacarpal III|3 rd digit of hand metacarpal bone|third finger metacarpal bone|third finger metacarpal|metacarpal of 3 rd digit of hand|metacarpal bone of 3 rd finger|manual digit 3 metacarpus|3 rd digit of hand metacarpal	http://purl.obolibrary.org/obo/UBERON_0003647		pheno_slim
UBERON:0003648	biolink:AnatomicalEntity	metacarpal bone of digit 4	A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 4.	UMLS:C1708990|EMAPA:19118|AAO:0010615|MA:0001367|NCIT:C52793|FMA:23902	hp.json	4 th digit of hand metacarpal|manual digit 4 metacarpus|fourth finger metacarpal bone|metacarpal bone of 4 th digit of hand|metacarpal of hand digit 4|metacarpal of 4 th finger|4 th finger metacarpal|metacarpal bone of hand digit 4|finger 4 metacarpus|4 th finger metacarpal bone|metacarpal 4|metacarpal bone of fourth finger|metacarpal bone digit 4|4 th digit of hand metacarpal bone|metacarpal bone of digit IV|fourth finger metacarpal|forelimb digit 4 metacarpus|hand digit 4 metacarpal|metacarpal of fourth finger|metacarpal of 4 th digit of hand|fourth metacarpal bone|metacarpal IV|hand digit 4 metacarpal bone|metacarpal bone of 4 th finger	http://purl.obolibrary.org/obo/UBERON_0003648		pheno_slim
HP:0500232	biolink:PhenotypicFeature	Abnormal CSF alanine concentration	Any deviation from the normal concentration of alanine in the cerebrospinal fluid.		hp.json	Abnormal alanine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500232		
HP:0500237	biolink:PhenotypicFeature	Decreased CSF histidine concentration	Abnormally decreased levels of histidine in cerebrospinal fluid.		hp.json	Low histidine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500237		
HP:0500238	biolink:PhenotypicFeature	Abnormal CSF albumin concentration	Any deviation from the normal concentration of albumin in the cerebrospinal fluid.		hp.json	Abnormal albumin levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500238		
HP:0500235	biolink:PhenotypicFeature	Abnormal CSF histidine concentration	Any deviation from the normal concentration of histidine in the cerebrospinal fluid.		hp.json	Abnormal histidine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500235		
HP:0500236	biolink:PhenotypicFeature	Increased CSF histidine concentration	Abnormally increased levels of histidine in cerebrospinal fluid.		hp.json	High histidine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500236		
HP:0500239	biolink:PhenotypicFeature	Increased CSF albumin concentration			hp.json	High albumin levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500239		
UBERON:0003656	biolink:AnatomicalEntity	mesopodium bone	A bone that is part of a mesopodial skeleton.	EMAPA:36579|MA:0000295	hp.json	mesopod bone|mesopodial bone|carpal/tarsal bone|basipodium bone	http://purl.obolibrary.org/obo/UBERON_0003656		
UBERON:0003657	biolink:AnatomicalEntity	limb joint	Any joint that is part of a (free) limb.	EMAPA:36501|galen:LimbJoint|MA:0000691|FMA:321558	hp.json	joint of limb|joint of limb skeletal system|skeletal limb joint	http://purl.obolibrary.org/obo/UBERON_0003657		grouping_class
UBERON:0003654	biolink:AnatomicalEntity	metatarsal bone of digit 5	A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 5.	NCIT:C52787|FMA:24506|MA:0001373|UMLS:C1709003|EMAPA:19131|AAO:0000929	hp.json	metatarsal 5|toe 5 metatarsus|metatarsal bone digit 5|metatarsal bone of digit V|metatarsal V|toe 5 metatarsal|metatarsal bone of foot digit 5|hindlimb digit 5 metatarsus|foot digit 5 metatarsal bone|fifth metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0003654		pheno_slim
UBERON:0003655	biolink:AnatomicalEntity	molar tooth	Molars are the rearmost and most complicated kind of tooth in most mammals.	BTO:0001759|NCIT:C33136|FMA:55638|MA:0000350|UMLS:C0026367|CALOHA:TS-0637|EMAPA:32897|MESH:D008963	hp.json	dens molaris|molar|molaris	http://purl.obolibrary.org/obo/UBERON_0003655		pheno_slim
UBERON:0003652	biolink:AnatomicalEntity	metatarsal bone of digit 3	A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 3[Automatically generated definition].	NCIT:C52789|EMAPA:19127|FMA:24504|UMLS:C1709001|MA:0001371|AAO:0000927	hp.json	hindlimb digit 3 metatarsal|toe 3 metatarsus|metatarsal bone digit 3|toe 3 metatarsal|metatarsal 3|hindlimb cannon bone|metatarsal bone of foot digit 3|third metatarsal bone|metatarsal III|foot digit 3 metatarsal bone|metatarsal bone of digit III	http://purl.obolibrary.org/obo/UBERON_0003652		pheno_slim
UBERON:0003653	biolink:AnatomicalEntity	metatarsal bone of digit 4	A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 4.	NCIT:C52788|EMAPA:19129|FMA:24505|UMLS:C1709002|MA:0001372|AAO:0000928	hp.json	hindlimb digit 4 metatarsus|toe 4 metatarsus|metatarsal 4|metatarsal bone digit 4|toe 4 metatarsal|metatarsal bone of foot digit 4|metatarsal IV|metatarsal bone of digit IV|fourth metatarsal bone|foot digit 4 metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0003653		pheno_slim
UBERON:0003650	biolink:AnatomicalEntity	metatarsal bone of digit 1	A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 1.	AAO:0000925|MA:0001369|EMAPA:19123|NCIT:C52791|FMA:24502|UMLS:C1708999	hp.json	foot digit 1 metatarsal bone|hallux metatarsal bone|toe 1 metatarsal|first metatarsal bone|metatarsal 1|hindlimb digit 1 metatarsus|metatarsal bone of hallux|metatarsal bone of foot digit 1|metatarsal I|metatarsal bone digit 1|toe 1 metatarsus|metatarsal bone of digit I	http://purl.obolibrary.org/obo/UBERON_0003650		pheno_slim
UBERON:0003651	biolink:AnatomicalEntity	metatarsal bone of digit 2	A metatarsal bone that distally_connected_to a proximal phalanx of pedal digit 2.	AAO:0000926|EMAPA:19125|NCIT:C52790|UMLS:C1709000|FMA:24503|MA:0001370	hp.json	toe 2 metatarsal|metatarsal II|metatarsal bone digit 2|metatarsal 2|metatarsal bone of digit II|metatarsal bone of foot digit 2|hindlimb digit 2 metatarsus|second metatarsal bone|toe 2 metatarsus|foot digit 2 metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0003651		pheno_slim
UBERON:0003638	biolink:AnatomicalEntity	manual digit 4 phalanx	A phalanx that is part of a hand digit 4 [Automatically generated definition].	MA:0001392|UMLS:C1708316|EMAPA:19119|FMA:35486|NCIT:C52774	hp.json	phalanx of ring finger|phalanx of 4 th finger|fourth finger phalanx|4 th digit of hand long bone of digit|phalanx of 4 th digit of hand|hand digit 4 phalanx|long bone of digit of hand digit 4|hand digit 4 digit long bone|hand digit 4 phalanx|fourth finger digit long bone|long bone of digit of 4 th finger|4 th finger long bone of digit|digit long bone of 4 th digit of hand|ring finger phalanx|4 th finger phalanx|phalanx of hand digit 4|digit long bone of fourth finger|fore limb digit 4 phalanx|4 th finger digit long bone|manual digit IV phalanx|digit long bone of hand digit 4|phalanx of fourth finger|4 th digit of hand phalanx|fourth finger long bone of digit|hand digit 4 long bone of digit|digit long bone of 4 th finger|4 th digit of hand digit long bone|long bone of digit of 4 th digit of hand|long bone of digit of fourth finger	http://purl.obolibrary.org/obo/UBERON_0003638		pheno_slim
HP:0500222	biolink:PhenotypicFeature	Increased CSF tryptophan concentration	Abnormally increased levels of tryptophan in cerebrospinal fluid.		hp.json	High tryptophan levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500222		
UBERON:0003639	biolink:AnatomicalEntity	manual digit 5 phalanx	A phalanx that is part of a hand digit 5 [Automatically generated definition].	EMAPA:19121|MA:0001393|UMLS:C1708317|FMA:35489|NCIT:C52773	hp.json	fifth finger phalanx|fifth finger long bone of digit|little finger phalanx|phalanx of fifth digit of hand|long bone of digit of 5 th digit of hand|5 th digit of hand digit long bone|phalanx of 5 th finger|5 th digit of hand long bone of digit|fifth finger digit long bone|long bone of digit of fifth finger|phalanx of manual digitus minimus|hand digit 5 phalanx|long bone of digit of hand digit 5|hand digit 5 digit long bone|phalanx of 5 th digit of hand|long bone of digit of 5 th finger|hand digit 5 phalanx|phalanx of fifth finger|5 th finger phalanx|phalanx of hand digit 5|5 th finger long bone of digit|digit long bone of 5 th digit of hand|phalanx of 5th finger|fore limb digit 5 phalanx|phalanx of little finger|digit long bone of fifth finger|digit long bone of hand digit 5|5 th finger digit long bone|manual digit V phalanx|5 th digit of hand phalanx|digit long bone of 5 th finger|hand digit 5 long bone of digit	http://purl.obolibrary.org/obo/UBERON_0003639		pheno_slim
HP:0500223	biolink:PhenotypicFeature	Increased CSF phenylalanine concentration	Abnormally increased levels of phenylalanine in cerebrospinal fluid.		hp.json	High phenylalanine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500223		
UBERON:0003636	biolink:AnatomicalEntity	manual digit 2 phalanx	A phalanx that is part of a hand digit 2 [Automatically generated definition].	MA:0001390|UMLS:C1708312|NCIT:C52776|EMAPA:19115|FMA:35480	hp.json	2 nd finger long bone of digit|second finger long bone of digit|digit long bone of 2 nd digit of hand|digit long bone of second finger|digit long bone of 2 nd finger|index finger phalanx|phalanx of manual digit 2|phalanx of second finger|hand digit 2 phalanx|phalanx of 2 nd finger|hand digit 2 phalanx|hand digit 2 digit long bone|long bone of digit of hand digit 2|2 nd digit of hand long bone of digit|2 nd digit of hand phalanx|manual digit II phalanx|long bone of digit of second finger|long bone of digit of 2 nd finger|phalanx of index finger|phalanx of hand digit 2|long bone of digit of 2 nd digit of hand|2 nd digit of hand digit long bone|hand digit 2 long bone of digit|2 nd finger phalanx|fore limb digit 2 phalanx|second finger phalanx|digit long bone of hand digit 2|2 nd finger digit long bone|second finger digit long bone|phalanx of 2 nd digit of hand	http://purl.obolibrary.org/obo/UBERON_0003636		pheno_slim
HP:0500220	biolink:PhenotypicFeature	Increased CSF tyrosine concentration	Abnormally increased levels of tyrosine in cerebrospinal fluid.		hp.json	High tyrosine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500220		
UBERON:0003637	biolink:AnatomicalEntity	manual digit 3 phalanx	A phalanx that is part of a hand digit 3 [Automatically generated definition].	MA:0001391|UMLS:C1708314|EMAPA:19117|NCIT:C52775|FMA:35483	hp.json	long bone of digit of 3 rd digit of hand|phalanx of 3 rd finger|3 rd digit of hand digit long bone|3 rd digit of hand long bone of digit|phalanx of middle finger|long bone of digit of third finger|third finger digit long bone|long bone of digit of 3 rd finger|phalanx of 3 rd digit of hand|long bone of digit of hand digit 3|hand digit 3 phalanx|hand digit 3 phalanx|hand digit 3 digit long bone|phalanx of third finger|3 rd finger long bone of digit|3 rd finger phalanx|digit long bone of 3 rd digit of hand|manual digit III phalanx|phalanx of hand digit 3|digit long bone of third finger|middle finger phalanx|3 rd finger digit long bone|fore limb digit 3 phalanx|digit long bone of hand digit 3|hand digit 3 long bone of digit|3 rd digit of hand phalanx|digit long bone of 3 rd finger|third finger long bone of digit|third finger phalanx	http://purl.obolibrary.org/obo/UBERON_0003637		pheno_slim
HP:0500221	biolink:PhenotypicFeature	Decreased CSF tyrosine concentration	Abnormally decreased levels of tyrosine in cerebrospinal fluid.		hp.json	Low tyrosine levels in the cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500221		
HP:0500226	biolink:PhenotypicFeature	Abnormal CSF serine concentration	Any deviation from the normal concentration of serine in the cerebrospinal fluid.		hp.json	Abnormal serine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500226		
GO:0045446	biolink:BiologicalProcess	endothelial cell differentiation	The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.		hp.json		http://purl.obolibrary.org/obo/GO_0045446		
HP:0500227	biolink:PhenotypicFeature	Increased CSF serine concentration	Abnormally increased levels of serine in cerebrospinal fluid.		hp.json	High serine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500227		
HP:0500224	biolink:PhenotypicFeature	Decreased CSF phenylalanine concentration	Abnormally decreased levels of phenylalanine in cerebrospinal fluid.		hp.json	Low phenylalanine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500224		
GO:0045444	biolink:BiologicalProcess	fat cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.		hp.json	adipocyte differentiation|adipose cell differentiation|adipogenesis|adipocyte cell differentiation	http://purl.obolibrary.org/obo/GO_0045444		
GO:0045445	biolink:BiologicalProcess	myoblast differentiation	The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.		hp.json	myoblast cell differentiation	http://purl.obolibrary.org/obo/GO_0045445		
HP:0500225	biolink:PhenotypicFeature	Abnormal CSF serine family amino acid concentration	Any deviation from the normal concentration of serine-family amino acids in the cerebrospinal fluid.		hp.json	Abnormal serine-family amino acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500225		
HP:0500228	biolink:PhenotypicFeature	Decreased CSF serine concentration	Abnormally decreased levels of serine in cerebrospinal fluid.		hp.json	Low serine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500228		
HP:0500229	biolink:PhenotypicFeature	Abnormal CSF glycine concentration	Any deviation from the normal concentration of glycine in the cerebrospinal fluid.		hp.json	Abnormal glycine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500229		
UBERON:0003645	biolink:AnatomicalEntity	metacarpal bone of digit 1	A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 1.	AAO:0010616|UMLS:C1708987|NCIT:C52796|EMAPA:19112|MA:0001364|FMA:23899	hp.json	thumb metacarpal|hand digit 1 metacarpal bone|metacarpal bone of thumb|forelimb digit 1 metacarpus|finger 1 metacarpus|metacarpal bone of first digit of hand|first metacarpal bone|metacarpal of hand digit 1|metacarpal bone of digit I|metacarpal of thumb|metacarpal of first digit of hand|hand digit 1 metacarpal|metacarpal I|thumb metacarpal bone|metacarpal bone of hand digit 1|metacarpal bone digit 1|first digit of hand metacarpal bone|metacarpal 1|manual digit 1 metacarpus|first digit of hand metacarpal	http://purl.obolibrary.org/obo/UBERON_0003645		pheno_slim
UBERON:0003646	biolink:AnatomicalEntity	metacarpal bone of digit 2	A metacarpal bone that distally_connected_to a proximal phalanx of manual digit 2.	UMLS:C1708988|NCIT:C52795|EMAPA:19114|MA:0001365|AAO:0000853|FMA:23900	hp.json	hand digit 2 metacarpal bone|second metacarpal bone|metacarpal bone of second finger|metacarpal bone of 2 nd finger|finger 2 metacarpus|2 nd digit of hand metacarpal|metacarpal of hand digit 2|forelimb digit 2 metacarpus|2 nd digit of hand metacarpal bone|metacarpal of 2 nd finger|metacarpal of second finger|metacarpal bone of digit II|metacarpal bone of hand digit 2|hand digit 2 metacarpal|metacarpal of 2 nd digit of hand|second finger metacarpal bone|metacarpal II|metacarpal bone digit 2|metacarpal 2|2 nd finger metacarpal bone|metacarpal bone of 2 nd digit of hand|manual digit 2 metacarpus|2 nd finger metacarpal|second finger metacarpal	http://purl.obolibrary.org/obo/UBERON_0003646		pheno_slim
UBERON:0003643	biolink:AnatomicalEntity	respiratory system arterial blood vessel	An arterial blood vessel that is part of a respiratory system [Automatically generated definition].	MA:0001800|EMAPA:37565	hp.json		http://purl.obolibrary.org/obo/UBERON_0003643		
UBERON:0003644	biolink:AnatomicalEntity	kidney arterial blood vessel	An arterial blood vessel that is part of a kidney [Automatically generated definition].	MA:0002578|EMAPA:31436	hp.json	kidney arterial system	http://purl.obolibrary.org/obo/UBERON_0003644		pheno_slim
UBERON:0003641	biolink:AnatomicalEntity	pedal digit 2 phalanx	A phalanx that is part of a foot digit 2 [Automatically generated definition].	NCIT:C52779|EMAPA:19126|UMLS:C1708082|FMA:32899|MA:0001382	hp.json	foot digit 2 digit long bone|hind limb digit 2 phalanx|foot digit 2 phalanx|long bone of digit of foot digit 2|foot digit 2 phalanx|foot digit 2 long bone of digit|second toe phalanx|phalanx of foot digit 2|pedal digit II phalanx|digit long bone of foot digit 2|phalanx of second toe	http://purl.obolibrary.org/obo/UBERON_0003641		pheno_slim
UBERON:0003642	biolink:AnatomicalEntity	pedal digit 3 phalanx	A phalanx that is part of a foot digit 3 [Automatically generated definition].	EMAPA:19128|FMA:32900|UMLS:C1708084|NCIT:C52780|MA:0001383	hp.json	pedal digit III phalanx|long bone of digit of foot digit 3|foot digit 3 digit long bone|hind limb digit 3 phalanx|foot digit 3 phalanx|foot digit 3 phalanx|third toe phalanx|phalanx of foot digit 3|foot digit 3 long bone of digit|digit long bone of foot digit 3|phalanx of third toe	http://purl.obolibrary.org/obo/UBERON_0003642		pheno_slim
UBERON:0003640	biolink:AnatomicalEntity	pedal digit 1 phalanx	A phalanx that is part of a foot digit 1 [Automatically generated definition].	NCIT:C52778|EMAPA:19124|UMLS:C1708080|MA:0001381|FMA:32884	hp.json	hallux phalanx|phalanx of great toe|long bone of digit of foot digit 1|hallux digit long bone|long bone of digit of hallux|foot digit 1 digit long bone|hind limb digit 1 phalanx|foot digit 1 phalanx|foot digit 1 long bone of digit|hallux long bone of digit|foot digit 1 phalanx|phalanx of first toe|phalanx of first digit of foot|big toe phalanx|phalanx of foot digit 1|phalanx of hallux|digit long bone of foot digit 1|digit long bone of hallux|phalanx of big toe|pedal digit I phalanx	http://purl.obolibrary.org/obo/UBERON_0003640		pheno_slim
CHEBI:22484	biolink:ChemicalSubstance	galactosamine oligosaccharide			hp.json	galactosamine oligosaccharides	http://purl.obolibrary.org/obo/CHEBI_22484		3_STAR
HP:0500211	biolink:PhenotypicFeature	Abnormal CSF threonine concentration	Any deviation from the normal concentration of threonine in the cerebrospinal fluid.		hp.json	Abnormal threonine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500211		
HP:0500212	biolink:PhenotypicFeature	Increased CSF threonine concentration	Abnormally increased levels of threonine in cerebrospinal fluid.		hp.json	High threonine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500212		
UBERON:0003625	biolink:AnatomicalEntity	manual digit 5	5th digit of the manus.	UMLS:C0230403|NCIT:C52838|MA:0000458|EHDAA2:0000535|FMA:24949|AAO:0010643|EMAPA:17441	hp.json	manus digiti minimi|little finger|fore limb digit 5|digit 5 of fore-paw|manual digit V|fore digit V|fifth finger|finger 5|fifth digit of hand|hand digit 5|manual digitus V|5th finger|manual digitus minimus|hand digit 5|5th digit of hand|manus quintus	http://purl.obolibrary.org/obo/UBERON_0003625		pheno_slim
HP:0500210	biolink:PhenotypicFeature	Increased CSF methionine concentration	Abnormally increased levels of methionine in cerebrospinal fluid.		hp.json	High methionine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500210		
HP:0500215	biolink:PhenotypicFeature	Abnormal CSF phenylalanine concentration	Any deviation from the normal concentration of phenylalanine in the cerebrospinal fluid.		hp.json	Abnormal phenylalanine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500215		
HP:0500216	biolink:PhenotypicFeature	Abnormal CSF aspartate concentration	Any deviation from the normal concentration of aspartic acid in the cerebrospinal fluid.		hp.json	Abnormal CSF aspartic acid concentration|Abnormal aspartic acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500216		
HP:0500213	biolink:PhenotypicFeature	Decreased CSF threonine concentration	Abnormally decreased levels of threonine in cerebrospinal fluid.		hp.json	Low threonine levels in the cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500213		
HP:0500214	biolink:PhenotypicFeature	Abnormal CSF aromatic amino acid concentration	Any deviation from the normal concentration of aromatic amino acids in the cerebrospinal fluid.		hp.json	Abnormal aromatic amino acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500214		
HP:0500219	biolink:PhenotypicFeature	Abnormal CSF tyrosine concentration	Any deviation from the normal concentration of tyrosine in the cerebrospinal fluid.		hp.json	Abnormal tyrosine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500219		
GO:0045453	biolink:BiologicalProcess	bone resorption	The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.	Wikipedia:Bone_resorption	hp.json		http://purl.obolibrary.org/obo/GO_0045453		
CHEBI:22483	biolink:ChemicalSubstance	amino oligosaccharide			hp.json	amino oligosaccharides	http://purl.obolibrary.org/obo/CHEBI_22483		3_STAR
HP:0500217	biolink:PhenotypicFeature	Increased CSF aspartate concentration	Abnormally increased levels of aspartic acid in cerebrospinal fluid.		hp.json	Increased CSF aspartic acid concentration|High aspartic acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500217		
CHEBI:22480	biolink:ChemicalSubstance	amino disaccharide	A disaccharide derivative that is a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.		hp.json	amino-disaccharides	http://purl.obolibrary.org/obo/CHEBI_22480		3_STAR
HP:0500218	biolink:PhenotypicFeature	Abnormal CSF tryptophan concentration	Any deviation from the normal concentration of tryptophan in the cerebrospinal fluid.		hp.json	Abnormal tryptophan levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500218		
UBERON:0003634	biolink:AnatomicalEntity	pedal digit 4	4th digit of the hind autopod.	UMLS:C1708085|EHDAA2:0002052|EMAPA:17469|BTO:0002352|MA:0000468|NCIT:C52842|AAO:0010656|FMA:25052	hp.json	hind digit 4|fourth digit of foot|digitus quartus [iv]|pedal digit IV|pes digit IV|4th toe|foot digit 4|digitus quartus (IV) pedis|hind digit IV|toe 4|foot digit 4|hind limb digit 4|fourth toe|digitus quartis pedis|digit 4 of hind-paw	http://purl.obolibrary.org/obo/UBERON_0003634		pheno_slim
UBERON:0003635	biolink:AnatomicalEntity	pedal digit 5	5th digit of the hind autopod.	EHDAA2:0002057|UMLS:C1708087|BTO:0002353|NCIT:C52843|MA:0000469|AAO:0010658|FMA:25053|EMAPA:17472	hp.json	digitus minimus; digitus quintus [v]|pedal digitus minimus|hind digit 5|fifth toe|little toe|digitus minimus pedis|digitus V of pes|digit 5 of hind-paw|5th toe|digitus quintus (V) pedis|fifth digit of foot|digitus quintus of pes|pes digit V|foot digit 5|foot digit 5|hind limb digit 5|hind digit V|digitus quintus [V]|digitus quintus [V] pedis|digitus quintus pedis|toe 5|pedal digit V	http://purl.obolibrary.org/obo/UBERON_0003635		pheno_slim
UBERON:0003632	biolink:AnatomicalEntity	pedal digit 2	2nd digit of the hind autopod.	EHDAA2:0002042|UMLS:C1708081|FMA:25048|BTO:0002350|MA:0000466|NCIT:C52840|AAO:0010645|EMAPA:17463	hp.json	hind digit 2|pedal digit II|pes digit II|digitus secundus [ii]|2nd toe|digitus secundus pedis|hind digit II|foot digit 2|digit 2 of hind-paw|second toe|digitus secundus (II) pedis|toe 2|hind limb digit 2|foot digit 2|second digit of foot	http://purl.obolibrary.org/obo/UBERON_0003632		pheno_slim
UBERON:0003633	biolink:AnatomicalEntity	pedal digit 3	3rd digit of the hind autopod.	UMLS:C1708083|BTO:0002351|NCIT:C52841|MA:0000467|AAO:0010646|EMAPA:17466|FMA:25051|EHDAA2:0002047	hp.json	toe 3|digitus tertius [iii]|hind digit 3|digitus tertius pedis|pes digit III|third digit of foot|digitus tertius (III) pedis|hind digit III|foot digit 3|3rd toe|digit 3 of hind-paw|pedal digit III|foot digit 3|hind limb digit 3|third toe	http://purl.obolibrary.org/obo/UBERON_0003633		pheno_slim
UBERON:0003631	biolink:AnatomicalEntity	pedal digit 1	1st digit of the hind autopod.	VSAO:0000201|FMA:25047|MA:0000465|AAO:0010644|UMLS:C1708079|BTO:0002349|EHDAA2:0002037|NCIT:C52839|EMAPA:17460|GAID:45|MESH:D006214	hp.json	digit 1 of pes|digitus primus pedis|hallux|hind digit 1|pes digit I|toe 1|hind digit I|foot digit 1|digit 1 of hind-paw|first toe|big toe|digitus primus (I) pedis|pedal digit I|hallex|hindlimb dewclaw|hallux; digitus primus [I]|hind limb digit 1|foot digit 1|large toe|great toe|preaxial digit of hindlimb|pedal digit 1	http://purl.obolibrary.org/obo/UBERON_0003631		pheno_slim
CHEBI:22495	biolink:ChemicalSubstance	aminobenzoic acid			hp.json	Aminobenzoesaeure|aminobenzoic acid	http://purl.obolibrary.org/obo/CHEBI_22495		3_STAR
UBERON:0003618	biolink:AnatomicalEntity	aorta tunica media	The middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers.	FMA:74433|MA:0002903|EMAPA:35138|SCTID:48467007	hp.json	tunica media of aorta|trunk of aortic tree tunica media|dorsal aorta tunica media|tunica media of adult aorta|adult aorta tunica media|tunica media of dorsal aorta|tunica media of trunk of aortic tree	http://purl.obolibrary.org/obo/UBERON_0003618		pheno_slim
UBERON:0003619	biolink:AnatomicalEntity	aorta tunica intima	The innermost layer of the aorta, containing the endothelium and an inner elastic membrane.	SCTID:362031007|MA:0002904|EMAPA:35137|BTO:0005553|FMA:74419	hp.json	tunica intima of adult aorta|dorsal aorta tunica intima|trunk of aortic tree tunica intima|tunica intima of dorsal aorta|tunica intima of aorta|tunica intima of trunk of aortic tree|adult aorta tunica intima	http://purl.obolibrary.org/obo/UBERON_0003619		pheno_slim
UBERON:0003616	biolink:AnatomicalEntity	bronchus elastic tissue	An elastic tissue that is part of a bronchus [Automatically generated definition].	MA:0001838|NCIT:C49211|UMLS:C1707053	hp.json	bronchial trunk elastic tissue|elastic tissue of bronchi|elastic tissue of bronchial trunk|elastic tissue of bronchus|bronchi elastic tissue|textus connectivus elasticus of bronchi|textus connectivus elasticus of bronchial trunk|elastic connective tissue of bronchus|bronchus textus connectivus elasticus|bronchi elastic connective tissue|bronchial trunk elastic connective tissue|elastic connective tissue of bronchi|bronchial trunk textus connectivus elasticus|elastic connective tissue of bronchial trunk|bronchus elastic connective tissue|textus connectivus elasticus of bronchus|bronchi textus connectivus elasticus	http://purl.obolibrary.org/obo/UBERON_0003616		
HP:0500200	biolink:PhenotypicFeature	Increased CSF glutamate concentration	Abnormally increased levels of glutamic acid in cerebrospinal fluid.		hp.json	High glutamic acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500200		
UBERON:0003617	biolink:AnatomicalEntity	trachea elastic tissue	An elastic tissue that is part of a trachea [Automatically generated definition].	MA:0001861	hp.json	windpipe textus connectivus elasticus|cartilaginous trachea elastic tissue|elastic connective tissue of windpipe|elastic tissue of vertebrate trachea|elastic tissue of cartilaginous trachea|windpipe elastic tissue|textus connectivus elasticus of cartilaginous trachea|elastic connective tissue of vertebrate trachea|textus connectivus elasticus of windpipe|windpipe elastic connective tissue|vertebrate trachea textus connectivus elasticus|cartilaginous trachea textus connectivus elasticus|elastic tissue of windpipe|cartilaginous trachea elastic connective tissue|vertebrate trachea elastic tissue|vertebrate trachea elastic connective tissue|textus connectivus elasticus of vertebrate trachea|elastic connective tissue of cartilaginous trachea	http://purl.obolibrary.org/obo/UBERON_0003617		
HP:0500201	biolink:PhenotypicFeature	Decreased CSF glutamate concentration	Abnormally decreased levels of glutamic acid in cerebrospinal fluid.		hp.json	Low glutamic acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500201		
UBERON:0003614	biolink:AnatomicalEntity	blood vessel elastic tissue	Elastic tissue layer that lines a blood vessel layer.	MA:0002856|EMAPA:36300	hp.json	blood vessel elastic connective tissue|elastic laminae|textus connectivus elasticus of blood vessel|elastic lamina|blood vessel textus connectivus elasticus|elastic tissue of blood vessel|vascular elastic laminae|vascular elastic laminae|vascular elastic lamina|elastic connective tissue of blood vessel|vascular elastic lamina|vascular elastic tissue	http://purl.obolibrary.org/obo/UBERON_0003614		pheno_slim
UBERON:0003615	biolink:AnatomicalEntity	lung elastic tissue	Elastic tissue that is part of a lung [Automatically generated definition].	MA:0002860	hp.json	elastic tissue of lung|elastic connective tissue of lung|lung textus connectivus elasticus|pulmonary elastic fiber|lung elastic connective tissue|pulmonary elastic fiber|textus connectivus elasticus of lung	http://purl.obolibrary.org/obo/UBERON_0003615		
HP:0500204	biolink:PhenotypicFeature	Decreased CSF arginine concentration	Abnormally decreased levels of arginine in cerebrospinal fluid.		hp.json	Low arginine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500204		
HP:0500205	biolink:PhenotypicFeature	Abnormal CSF aspartate family amino acid concentration	Any deviation from the normal concentration of aspartate-family amino acids in the cerebrospinal fluid.		hp.json	Abnormal aspartate-family amino acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500205		
HP:0500202	biolink:PhenotypicFeature	Abnormal CSF arginine concentration	Any deviation from the normal concentration of arginine in the cerebrospinal fluid.		hp.json	Abnormal arginine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500202		
HP:0500203	biolink:PhenotypicFeature	Increased CSF arginine concentration	Abnormally increased levels of arginine in cerebrospinal fluid.		hp.json	High arginine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500203		
HP:0500208	biolink:PhenotypicFeature	Increased CSF lysine concentration	Abnormally increased levels of lysine in cerebrospinal fluid.		hp.json	High lysine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500208		
HP:0500209	biolink:PhenotypicFeature	Abnormal CSF methionine concentration	Any deviation from the normal concentration of methionine in the cerebrospinal fluid.		hp.json	Abnormal methionine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500209		
CHEBI:22494	biolink:ChemicalSubstance	aminobenzoate			hp.json	aminobenzoates	http://purl.obolibrary.org/obo/CHEBI_22494		3_STAR
HP:0500206	biolink:PhenotypicFeature	Abnormal CSF lysine concentration	Any deviation from the normal concentration of lysine in the cerebrospinal fluid.		hp.json	Abnormal lysine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500206		
HP:0500207	biolink:PhenotypicFeature	Decreased CSF lysine concentration	Abnormally decreased levels of lysine in cerebrospinal fluid.		hp.json	Low lysine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500207		
GO:0070405	biolink:MolecularActivity	ammonium ion binding	Binding to ammonium ions (NH4+).		hp.json	ammonium binding	http://purl.obolibrary.org/obo/GO_0070405		
UBERON:0003623	biolink:AnatomicalEntity	manual digit 3	3rd digit of the manus.	NCIT:C52836|UMLS:C0230393|EMAPA:17435|MA:0000456|EHDAA2:0000523|FMA:24947|AAO:0010641	hp.json	middle finger|long finger|3rd digit of hand|manual digit III|fore limb digit 3|3rd finger|third digit of hand|digitus medius|third finger|hand digit 3|finger 3|digit 3 of fore-paw|hand digit 3|fore digit III	http://purl.obolibrary.org/obo/UBERON_0003623		pheno_slim
UBERON:0003624	biolink:AnatomicalEntity	manual digit 4	4th digit of the manus.	UMLS:C0230398|NCIT:C52837|EMAPA:17438|EHDAA2:0000529|MA:0000457|FMA:24948|AAO:0010642	hp.json	fore limb digit 4|manual digit IV|fourth digit of hand|hand digit 4|4th finger|fourth finger|ring finger|digitus annularis|digit 4 of fore-paw|hand digit 4|4th digit of hand|fore digit IV|finger 4	http://purl.obolibrary.org/obo/UBERON_0003624		pheno_slim
UBERON:0003622	biolink:AnatomicalEntity	manual digit 2	2nd digit of the manus.	AAO:0010640|NCIT:C52835|EHDAA2:0000517|MA:0000455|EMAPA:17432|UMLS:C0230388|FMA:24946	hp.json	fore limb digit 2|second finger|hand digit 2|second digit of hand|digit 2 of fore-paw|fore digit II|2nd finger|2nd digit of hand|index finger|hand digit 2|finger 2|manual digit II	http://purl.obolibrary.org/obo/UBERON_0003622		pheno_slim
UBERON:0003620	biolink:AnatomicalEntity	manual digit 1 phalanx	A phalanx that is part of a hand digit 1 [Automatically generated definition].	FMA:35477|NCIT:C52777|MA:0001389|EMAPA:19113|UMLS:C1711344	hp.json	phalanx of thumb|hand digit 1 phalanx|manual digit I phalanx|phalanx of hand digit 1|thumb phalanx|fore limb digit 1 phalanx|hand digit 1 phalanx	http://purl.obolibrary.org/obo/UBERON_0003620		pheno_slim
HP:0030572	biolink:PhenotypicFeature	Pinhole visual acuity 0.4 LogMAR		UMLS:C4073045	hp.json		http://purl.obolibrary.org/obo/HP_0030572		
HP:0030573	biolink:PhenotypicFeature	Pinhole visual acuity 0.5 LogMAR		UMLS:C4073046	hp.json		http://purl.obolibrary.org/obo/HP_0030573		
HP:0030574	biolink:PhenotypicFeature	Pinhole visual acuity 0.6 LogMAR		UMLS:C4073047	hp.json		http://purl.obolibrary.org/obo/HP_0030574		
HP:0030575	biolink:PhenotypicFeature	Pinhole visual acuity 0.7 LogMAR		UMLS:C4073048	hp.json		http://purl.obolibrary.org/obo/HP_0030575		
HP:0030570	biolink:PhenotypicFeature	Pinhole visual acuity 0.2 LogMAR		UMLS:C4073043	hp.json		http://purl.obolibrary.org/obo/HP_0030570		
HP:0030571	biolink:PhenotypicFeature	Pinhole visual acuity 0.3 LogMAR		UMLS:C4073044	hp.json		http://purl.obolibrary.org/obo/HP_0030571		
HP:0030576	biolink:PhenotypicFeature	Pinhole visual acuity 0.8 LogMAR		UMLS:C4073049	hp.json		http://purl.obolibrary.org/obo/HP_0030576		
HP:0030577	biolink:PhenotypicFeature	Pinhole visual acuity 0.9 LogMAR		UMLS:C4073050	hp.json		http://purl.obolibrary.org/obo/HP_0030577		
HP:0030578	biolink:PhenotypicFeature	Pinhole visual acuity 1.0 LogMAR		UMLS:C4073051	hp.json		http://purl.obolibrary.org/obo/HP_0030578		
HP:0030579	biolink:PhenotypicFeature	Pinhole visual acuity 1.1 LogMAR		UMLS:C4073052	hp.json		http://purl.obolibrary.org/obo/HP_0030579		
GO:0033483	biolink:BiologicalProcess	gas homeostasis	A homeostatic process involved in the maintenance of an internal steady state of a gas within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0033483		
HP:0030583	biolink:PhenotypicFeature	Pinhole visual acuity 3.0 LogMAR		UMLS:C4073056	hp.json		http://purl.obolibrary.org/obo/HP_0030583		
HP:0030584	biolink:PhenotypicFeature	Color vision test abnormality		UMLS:C4073057	hp.json	Colour vision test abnormality	http://purl.obolibrary.org/obo/HP_0030584		
HP:0030585	biolink:PhenotypicFeature	Red desaturation		UMLS:C4073058	hp.json		http://purl.obolibrary.org/obo/HP_0030585		
HP:0030586	biolink:PhenotypicFeature	Abnormal Ishihara plate test		UMLS:C4073059	hp.json		http://purl.obolibrary.org/obo/HP_0030586		
HP:0030580	biolink:PhenotypicFeature	Pinhole visual acuity 1.2 LogMAR		UMLS:C4073053	hp.json		http://purl.obolibrary.org/obo/HP_0030580		
HP:0030581	biolink:PhenotypicFeature	Pinhole visual acuity 1.3 LogMAR		UMLS:C4073054	hp.json		http://purl.obolibrary.org/obo/HP_0030581		
HP:0030582	biolink:PhenotypicFeature	Pinhole visual acuity 2.0 LogMAR		UMLS:C4073055	hp.json		http://purl.obolibrary.org/obo/HP_0030582		
HP:0030587	biolink:PhenotypicFeature	Abnormal Hardy-Rand-Rittler plate test		UMLS:C4073060	hp.json		http://purl.obolibrary.org/obo/HP_0030587		
HP:0030588	biolink:PhenotypicFeature	Abnormal visual field test	Abnormal result of a test designed to test an individual's central and peripheral vision by determining the ability of the individual to perceive objects at differing locations of the visual field.	UMLS:C0854021	hp.json		http://purl.obolibrary.org/obo/HP_0030588		
HP:0030589	biolink:PhenotypicFeature	Abnormal confrontational visual field test		UMLS:C4073061	hp.json		http://purl.obolibrary.org/obo/HP_0030589		
HP:0030594	biolink:PhenotypicFeature	Abnormal automated kinetic perimetry test		UMLS:C4073066	hp.json		http://purl.obolibrary.org/obo/HP_0030594		
HP:0030595	biolink:PhenotypicFeature	Abnormal static automated perimetry test		UMLS:C4073067	hp.json		http://purl.obolibrary.org/obo/HP_0030595		
HP:0030596	biolink:PhenotypicFeature	Abnormal Humphrey SITA 30-2 perimetry test		UMLS:C4073068	hp.json		http://purl.obolibrary.org/obo/HP_0030596		
HP:0030597	biolink:PhenotypicFeature	Abnormal Humphrey SITA 24-2 perimetry test		UMLS:C4073069	hp.json		http://purl.obolibrary.org/obo/HP_0030597		
HP:0030590	biolink:PhenotypicFeature	Abnormal Amsler grid test		UMLS:C4073062	hp.json		http://purl.obolibrary.org/obo/HP_0030590		
HP:0030591	biolink:PhenotypicFeature	Abnormal kinetic perimetry test		UMLS:C4073063	hp.json		http://purl.obolibrary.org/obo/HP_0030591		
HP:0030592	biolink:PhenotypicFeature	Abnormal static perimetry test		UMLS:C4073064	hp.json		http://purl.obolibrary.org/obo/HP_0030592		
HP:0030593	biolink:PhenotypicFeature	Abnormal manual kinetic perimetry test		UMLS:C4073065	hp.json		http://purl.obolibrary.org/obo/HP_0030593		
HP:0030598	biolink:PhenotypicFeature	Abnormal Humphrey SITA 10-2 perimetry test		UMLS:C4073070	hp.json		http://purl.obolibrary.org/obo/HP_0030598		
HP:0005587	biolink:PhenotypicFeature	Profuse pigmented skin lesions		UMLS:C1834424	hp.json		http://purl.obolibrary.org/obo/HP_0005587		
HP:0005588	biolink:PhenotypicFeature	Patchy palmoplantar hyperkeratosis	A focal type of palmoplantar keratoderma in which only certain areas of the palms and soles are affected.	UMLS:C4021633	hp.json	Palmoplantar keratoderma, patchy|Patchy palmoplantar keratoderma	http://purl.obolibrary.org/obo/HP_0005588		
HP:0030599	biolink:PhenotypicFeature	Abnormal Estermann grid perimetry test		UMLS:C4073071	hp.json		http://purl.obolibrary.org/obo/HP_0030599		
HP:0005583	biolink:PhenotypicFeature	Tubular basement membrane disintegration	DIsruption and breaking up of the basement membrane of the tubules of the kidney.	UMLS:C1968618	hp.json	Disintegration of the tubular basement membrane	http://purl.obolibrary.org/obo/HP_0005583		
HP:0005584	biolink:PhenotypicFeature	Renal cell carcinoma	A type of carcinoma of the kidney with origin in the epithelium of the proximal convoluted renal tubule.	UMLS:C0007134|SNOMEDCT_US:41607009|SNOMEDCT_US:702391001|NCIT:C2916|MSH:D002292	hp.json	Hypernephroma|Cancer starting in small tubes in kidneys|Renal carcinoma	http://purl.obolibrary.org/obo/HP_0005584		
HP:0005585	biolink:PhenotypicFeature	Spotty hyperpigmentation		UMLS:C3806179	hp.json	Spotty increased pigmentation|Patchy hyperpigmentation	http://purl.obolibrary.org/obo/HP_0005585		
HP:0005586	biolink:PhenotypicFeature	Hyperpigmentation in sun-exposed areas		UMLS:C3805877	hp.json	Increased pigmentation in sun-exposed areas|Hyperpigmentation of exposed areas	http://purl.obolibrary.org/obo/HP_0005586		
HP:0005580	biolink:PhenotypicFeature	Duplication of renal pelvis	A duplication of the renal pelvis.	UMLS:C1839269	hp.json		http://purl.obolibrary.org/obo/HP_0005580		
HP:0005598	biolink:PhenotypicFeature	Facial telangiectasia in butterfly midface distribution	Telangiectases (small dilated blood vessels) located near the surface of the skin in a butterfly midface distribution.	UMLS:C4021632	hp.json	Butterfly facial telangiectasia	http://purl.obolibrary.org/obo/HP_0005598		
HP:0005599	biolink:PhenotypicFeature	Hypopigmentation of hair		UMLS:C3278401	hp.json	Loss of hair colour|Loss of hair color|Hair hypopigmentation	http://purl.obolibrary.org/obo/HP_0005599		hposlim_core
HP:0005595	biolink:PhenotypicFeature	Generalized hyperkeratosis		UMLS:C1969913	hp.json	Hyperkeratosis, generalised|Generalised hyperkeratosis|Hyperkeratosis, generalized	http://purl.obolibrary.org/obo/HP_0005595		
HP:0005597	biolink:PhenotypicFeature	Congenital alopecia totalis	Loss of all scalp hair with congenital onset.	UMLS:C4025175	hp.json		http://purl.obolibrary.org/obo/HP_0005597		
HP:0005590	biolink:PhenotypicFeature	Spotty hypopigmentation		UMLS:C3806178	hp.json	Patchy hypopigmentation|Patchy depigmentation|Spotty decreased pigmentation	http://purl.obolibrary.org/obo/HP_0005590		
HP:0005592	biolink:PhenotypicFeature	Giant melanosomes in melanocytes	The presence of large spherical melanosomes (1 to 6 micrometer in diameter) in the cytoplasm of melanocytes.	UMLS:C3806221	hp.json	Macromelanosomes	http://purl.obolibrary.org/obo/HP_0005592		
HP:0005593	biolink:PhenotypicFeature	Macular hypopigmented whorls, streaks, and patches		UMLS:C3806616	hp.json		http://purl.obolibrary.org/obo/HP_0005593		
HP:0030530	biolink:PhenotypicFeature	Arcuate scotoma		UMLS:C0271198|MSH:D012607|UMLS:C4280302|SNOMEDCT_US:15462009	hp.json	Arc-shaped blind spot	http://purl.obolibrary.org/obo/HP_0030530		
HP:0030531	biolink:PhenotypicFeature	Altitudinal visual field defect		UMLS:C4073005	hp.json		http://purl.obolibrary.org/obo/HP_0030531		
GO:0008483	biolink:MolecularActivity	transaminase activity	Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.	Reactome:R-HSA-1237102|EC:2.6.1.-	hp.json	aminotransferase activity	http://purl.obolibrary.org/obo/GO_0008483		
HP:0030536	biolink:PhenotypicFeature	Unaided visual acuity 0.1 LogMAR		UMLS:C4073010	hp.json		http://purl.obolibrary.org/obo/HP_0030536		
HP:0030537	biolink:PhenotypicFeature	Unaided visual acuity 0.2 LogMAR		UMLS:C4073011	hp.json		http://purl.obolibrary.org/obo/HP_0030537		
HP:0030538	biolink:PhenotypicFeature	Unaided visual acuity 0.3 LogMAR		UMLS:C4073012	hp.json		http://purl.obolibrary.org/obo/HP_0030538		
HP:0030539	biolink:PhenotypicFeature	Unaided visual acuity 0.4 LogMAR		UMLS:C4073013	hp.json		http://purl.obolibrary.org/obo/HP_0030539		
HP:0030532	biolink:PhenotypicFeature	Visual acuity test abnormality		UMLS:C4073006	hp.json		http://purl.obolibrary.org/obo/HP_0030532		
HP:0030533	biolink:PhenotypicFeature	Abnormal unaided visual acuity test		UMLS:C4073007	hp.json		http://purl.obolibrary.org/obo/HP_0030533		
HP:0030534	biolink:PhenotypicFeature	Abnormal best corrected visual acuity test		UMLS:C4073008	hp.json		http://purl.obolibrary.org/obo/HP_0030534		
HP:0030535	biolink:PhenotypicFeature	Abnormal pinhole visual acuity test		UMLS:C4073009	hp.json		http://purl.obolibrary.org/obo/HP_0030535		
CHEBI:138141	biolink:ChemicalSubstance	17alpha-hydroxy-C21-steroid	Any C21-steroid carrying a hydroxy substituent at the 17alpha-position. Note that individual examples may have ring substituents at other positions and/or contain double bonds, aromatic A-rings, expanded/contracted rings etc., so the formula and mass may vary from that given for the generic structure.	MetaCyc:17a-hydroxy-C21-steroids	hp.json	a 17alpha-hydroxy-C21-steroid	http://purl.obolibrary.org/obo/CHEBI_138141		3_STAR
HP:0030540	biolink:PhenotypicFeature	Unaided visual acuity 0.5 LogMAR		UMLS:C4073014	hp.json		http://purl.obolibrary.org/obo/HP_0030540		
HP:0030541	biolink:PhenotypicFeature	Unaided visual acuity 0.6 LogMAR		UMLS:C4073015	hp.json		http://purl.obolibrary.org/obo/HP_0030541		
HP:0030542	biolink:PhenotypicFeature	Unaided visual acuity 0.7 LogMAR		UMLS:C4073016	hp.json		http://purl.obolibrary.org/obo/HP_0030542		
HP:0030547	biolink:PhenotypicFeature	Unaided visual acuity 1.2 LogMAR		UMLS:C4073021	hp.json		http://purl.obolibrary.org/obo/HP_0030547		
HP:0030548	biolink:PhenotypicFeature	Unaided visual acuity 1.3 LogMAR		UMLS:C4073022	hp.json		http://purl.obolibrary.org/obo/HP_0030548		
PR:000009758	biolink:Protein	leptin	A protein that is a translation product of the human LEP gene or a 1:1 ortholog thereof.		hp.json	OB|LEP|obese protein|OBS|obesity factor	http://purl.obolibrary.org/obo/PR_000009758		
HP:0030549	biolink:PhenotypicFeature	Unaided visual acuity 2.0 LogMAR		UMLS:C4073023	hp.json		http://purl.obolibrary.org/obo/HP_0030549		
HP:0030543	biolink:PhenotypicFeature	Unaided visual acuity 0.8 LogMAR		UMLS:C4073017	hp.json		http://purl.obolibrary.org/obo/HP_0030543		
HP:0030544	biolink:PhenotypicFeature	Unaided visual acuity 0.9 LogMAR		UMLS:C4073018	hp.json		http://purl.obolibrary.org/obo/HP_0030544		
HP:0030545	biolink:PhenotypicFeature	Unaided visual acuity 1.0 LogMAR		UMLS:C4073019	hp.json		http://purl.obolibrary.org/obo/HP_0030545		
HP:0030546	biolink:PhenotypicFeature	Unaided visual acuity 1.1 LogMAR		UMLS:C4073020	hp.json		http://purl.obolibrary.org/obo/HP_0030546		
HP:0030550	biolink:PhenotypicFeature	Unaided visual acuity 3.0 LogMAR		UMLS:C4073024	hp.json		http://purl.obolibrary.org/obo/HP_0030550		
HP:0030551	biolink:PhenotypicFeature	Visual acuity light perception with projection		UMLS:C4073025	hp.json		http://purl.obolibrary.org/obo/HP_0030551		
HP:0030552	biolink:PhenotypicFeature	Visual acuity light perception without projection		UMLS:C4073026	hp.json		http://purl.obolibrary.org/obo/HP_0030552		
HP:0030553	biolink:PhenotypicFeature	Visual acuity no light perception		SNOMEDCT_US:63063006|UMLS:C0442774	hp.json		http://purl.obolibrary.org/obo/HP_0030553		
HP:0030558	biolink:PhenotypicFeature	Best corrected visual acuity 0.5 LogMAR		UMLS:C4073031	hp.json		http://purl.obolibrary.org/obo/HP_0030558		
HP:0030559	biolink:PhenotypicFeature	Best corrected visual acuity 0.7 LogMAR		UMLS:C4073032	hp.json		http://purl.obolibrary.org/obo/HP_0030559		
HP:0030554	biolink:PhenotypicFeature	Best corrected visual acuity 0.1 LogMAR		UMLS:C4073027	hp.json		http://purl.obolibrary.org/obo/HP_0030554		
HP:0030555	biolink:PhenotypicFeature	Best corrected visual acuity 0.2 LogMAR		UMLS:C4073028	hp.json		http://purl.obolibrary.org/obo/HP_0030555		
HP:0030556	biolink:PhenotypicFeature	Best corrected visual acuity 0.3 LogMAR		UMLS:C4073029	hp.json		http://purl.obolibrary.org/obo/HP_0030556		
HP:0030557	biolink:PhenotypicFeature	Best corrected visual acuity 0.4 LogMAR		UMLS:C4073030	hp.json		http://purl.obolibrary.org/obo/HP_0030557		
HP:0030561	biolink:PhenotypicFeature	Best corrected visual acuity 0.8 LogMAR		UMLS:C4073034	hp.json		http://purl.obolibrary.org/obo/HP_0030561		
HP:0030562	biolink:PhenotypicFeature	Best corrected visual acuity 0.9 LogMAR		UMLS:C4073035	hp.json		http://purl.obolibrary.org/obo/HP_0030562		
HP:0030563	biolink:PhenotypicFeature	Best corrected visual acuity 1.0 LogMAR		UMLS:C4073036	hp.json		http://purl.obolibrary.org/obo/HP_0030563		
HP:0030564	biolink:PhenotypicFeature	Best corrected visual acuity 1.1 LogMAR		UMLS:C4073037	hp.json		http://purl.obolibrary.org/obo/HP_0030564		
HP:0030560	biolink:PhenotypicFeature	Best corrected visual acuity 0.6 LogMAR		UMLS:C4073033	hp.json		http://purl.obolibrary.org/obo/HP_0030560		
GO:0008482	biolink:MolecularActivity	sulfite oxidase activity	Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate.	MetaCyc:SULFITE-OXIDASE-RXN|EC:1.8.3.1|MetaCyc:PWY-5326|KEGG_REACTION:R00533|RHEA:24600|Reactome:R-HSA-1614544	hp.json	sulphite oxidase activity|sulfite:oxygen oxidoreductase activity	http://purl.obolibrary.org/obo/GO_0008482		
HP:0030569	biolink:PhenotypicFeature	Pinhole visual acuity 0.1 LogMAR		UMLS:C4073042	hp.json		http://purl.obolibrary.org/obo/HP_0030569		
HP:0030565	biolink:PhenotypicFeature	Best corrected visual acuity 1.2 LogMAR		UMLS:C4073038	hp.json		http://purl.obolibrary.org/obo/HP_0030565		
HP:0030566	biolink:PhenotypicFeature	Best corrected visual acuity 1.3 LogMAR		UMLS:C4073039	hp.json		http://purl.obolibrary.org/obo/HP_0030566		
HP:0030567	biolink:PhenotypicFeature	Best corrected visual acuity 2.0 LogMAR		UMLS:C4073040	hp.json		http://purl.obolibrary.org/obo/HP_0030567		
HP:0030568	biolink:PhenotypicFeature	Best corrected visual acuity 3.0 LogMAR		UMLS:C4073041	hp.json		http://purl.obolibrary.org/obo/HP_0030568		
CHEBI:138131	biolink:ChemicalSubstance	Delta(5),Delta(7)-sterol	Any sterol containing two double bonds between positions 5-6 and 7-8.	MetaCyc:Delta5-Delta7-Steroids	hp.json	a Delta(5),Delta(7)-sterol	http://purl.obolibrary.org/obo/CHEBI_138131		3_STAR
OBO:MAXO_0000340	biolink:NamedThing	biopsy of breast	Removal of tissue from the breast.		hp.json	breast biopsy	http://purl.obolibrary.org/obo/MAXO_0000340		
OBO:MAXO_0000343	biolink:NamedThing	biopsy of cardiac ventricle	Removal of tissue from the cardiac ventricle.		hp.json	cardiac ventricle biopsy	http://purl.obolibrary.org/obo/MAXO_0000343		
OBO:MAXO_0000344	biolink:NamedThing	biopsy of cerebellum	Removal of tissue from the cerebellum.		hp.json	cerebellum biopsy	http://purl.obolibrary.org/obo/MAXO_0000344		
OBO:MAXO_0000341	biolink:NamedThing	biopsy of bronchus	Removal of tissue from the bronchus.		hp.json	bronchus biopsy	http://purl.obolibrary.org/obo/MAXO_0000341		
OBO:MAXO_0000342	biolink:NamedThing	biopsy of caecum	Removal of tissue from the caecum.		hp.json	caecum biopsy	http://purl.obolibrary.org/obo/MAXO_0000342		
HP:0005525	biolink:PhenotypicFeature	Spontaneous hemolytic crises		UMLS:C4025184	hp.json		http://purl.obolibrary.org/obo/HP_0005525		
HP:0005526	biolink:PhenotypicFeature	Lymphoid leukemia	A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. This category includes precursor or acute lymphoblastic leukemias and chronic leukemias.	UMLS:C0023448|MSH:D007945|SNOMEDCT_US:32280000|SNOMEDCT_US:188725004	hp.json	Lymphoid leukaemia	http://purl.obolibrary.org/obo/HP_0005526		
HP:0005527	biolink:PhenotypicFeature	Reduced kininogen activity	Reduction in the amount of kininogen, which functions as a cofactor in the contact phase of the intrinsic blood coagulation cascade.	MSH:C537060|UMLS:C0272340|SNOMEDCT_US:27312002	hp.json	Williams factor deficiency|Fitzgerald factor deficiency|Kininogen deficiency|Williams-Fitzgerald-Flaujeac factor deficiency	http://purl.obolibrary.org/obo/HP_0005527		
HP:0005528	biolink:PhenotypicFeature	Bone marrow hypocellularity	A reduced number of hematopoietic cells present in the bone marrow relative to marrow fat.	UMLS:C1855710	hp.json	Bone marrow hypoplasia|Bone marrow failure|Hypoplastic bone marrow	http://purl.obolibrary.org/obo/HP_0005528		
HP:0005521	biolink:PhenotypicFeature	Disseminated intravascular coagulation	Disseminated intravascular coagulation is characterized by the widespread activation of coagulation, which results in the intravascular formation of fibrin and ultimately thrombotic occlusion of small and midsize vessels.	MSH:D004211|UMLS:C0012739|SNOMEDCT_US:67406007	hp.json		http://purl.obolibrary.org/obo/HP_0005521		
HP:0005522	biolink:PhenotypicFeature	Pyridoxine-responsive sideroblastic anemia	A type of sideroblastic anemia that is alleviated by pyridoxine (vitamin B-6) treatment.	SNOMEDCT_US:25443007|SNOMEDCT_US:191260004|UMLS:C0272027	hp.json	Pyridoxine-responsive sideroblastic anaemia	http://purl.obolibrary.org/obo/HP_0005522		
UBERON:3000961	biolink:AnatomicalEntity	external integument structure	Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument.		hp.json		http://purl.obolibrary.org/obo/UBERON_3000961		
HP:0005523	biolink:PhenotypicFeature	Lymphoproliferative disorder		UMLS:C0024314|SNOMEDCT_US:414629003|MSH:D008232|SNOMEDCT_US:84631004|SNOMEDCT_US:277466009|SNOMEDCT_US:77121009	hp.json	Lymphoproliferative disorders	http://purl.obolibrary.org/obo/HP_0005523		
HP:0005524	biolink:PhenotypicFeature	Macrocytic hemolytic disease		UMLS:C4025185	hp.json		http://purl.obolibrary.org/obo/HP_0005524		
OBO:MAXO_0000347	biolink:NamedThing	biopsy of chordate pharynx	Removal of tissue from the chordate pharynx.		hp.json	chordate pharynx biopsy	http://purl.obolibrary.org/obo/MAXO_0000347		
OBO:MAXO_0000348	biolink:NamedThing	biopsy of choroid plexus	Removal of tissue from the choroid plexus.		hp.json	choroid plexus biopsy	http://purl.obolibrary.org/obo/MAXO_0000348		
OBO:MAXO_0000345	biolink:NamedThing	biopsy of cerebral cortex	Removal of tissue from the cerebral cortex.		hp.json	cerebral cortex biopsy	http://purl.obolibrary.org/obo/MAXO_0000345		
OBO:MAXO_0000346	biolink:NamedThing	biopsy of chest wall	Removal of tissue from the chest wall.		hp.json	chest wall biopsy	http://purl.obolibrary.org/obo/MAXO_0000346		
HP:0005520	biolink:PhenotypicFeature	Chronic disseminated intravascular coagulation	A chronic form of disseminated intravascular coagulation in which a persistent weak or intermittent activating stimulus is present and destruction and production of coagulation factors and platelets are balanced.	UMLS:C1862184	hp.json	Chronic consumption coagulopathy|Compensated disseminated intravascular coagulation	http://purl.obolibrary.org/obo/HP_0005520		
OBO:MAXO_0000349	biolink:NamedThing	biopsy of cochlea	Removal of tissue from the cochlea.		hp.json	cochlea biopsy	http://purl.obolibrary.org/obo/MAXO_0000349		
GO:0070382	biolink:CellularComponent	exocytic vesicle	A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.		hp.json	exocytotic vesicle|exocytic constitutive secretory pathway transport vesicle	http://purl.obolibrary.org/obo/GO_0070382		
OBO:MAXO_0000332	biolink:NamedThing	biopsy of anus	Removal of tissue from the anus.	NCIT:C51586	hp.json	anus biopsy	http://purl.obolibrary.org/obo/MAXO_0000332		
OBO:MAXO_0000333	biolink:NamedThing	biopsy of aorta	Removal of tissue from the aorta.		hp.json	aorta biopsy	http://purl.obolibrary.org/obo/MAXO_0000333		
OBO:MAXO_0000330	biolink:NamedThing	biopsy of adrenal gland	Removal of tissue from the adrenal gland.		hp.json	adrenal gland biopsy	http://purl.obolibrary.org/obo/MAXO_0000330		
OBO:MAXO_0000331	biolink:NamedThing	biopsy of anal canal	Removal of tissue from the anal canal.		hp.json	anal canal biopsy	http://purl.obolibrary.org/obo/MAXO_0000331		
UBERON:3000981	biolink:AnatomicalEntity	limb external integument structure	Dermal, epidermal, glandular and pigment structures of the limb integument.		hp.json		http://purl.obolibrary.org/obo/UBERON_3000981		
HP:0030503	biolink:PhenotypicFeature	Macular telangiectasia		UMLS:C0339480|SNOMEDCT_US:232024000	hp.json	Parafoveal telangiectasia|Juxtafoveal telangiectasia	http://purl.obolibrary.org/obo/HP_0030503		
UBERON:3000977	biolink:AnatomicalEntity	body external integument structure	Dermal, epidermal, glandular and pigment structures of the body integument.		hp.json		http://purl.obolibrary.org/obo/UBERON_3000977		
HP:0005537	biolink:PhenotypicFeature	Decreased mean platelet volume	Average platelet volume below the lower limit of the normal reference interval.	UMLS:C1833182|UMLS:C1096368	hp.json	Small platelets|Small platelet size|Small platelets size	http://purl.obolibrary.org/obo/HP_0005537		
HP:0030504	biolink:PhenotypicFeature	Grouped congenital hypertrophy of retinal pigment epithelium		UMLS:C4072989	hp.json	Bear track congenital hypertrophy of retinal pigment epithelium	http://purl.obolibrary.org/obo/HP_0030504		
HP:0030505	biolink:PhenotypicFeature	Nummular pigmentation of the fundus	Clumped pigmentary changes of nummular appearance (i.e., thought to resemble the shape of a coin or multiple coins stuck together) at the level of the retinal pigment epithelium.	UMLS:C4072990	hp.json	Nummular pigmentation of the retina	http://purl.obolibrary.org/obo/HP_0030505		
HP:0030506	biolink:PhenotypicFeature	Yellow/white lesions of the retina		UMLS:C4072991	hp.json		http://purl.obolibrary.org/obo/HP_0030506		
HP:0005539	biolink:PhenotypicFeature	T cell chronic lymphocytic lymphoma/leukemia	A form of lymphoid leukemia or lymphoma in which too many T-cell lymphoblasts are found in the blood, bone marrow, and tissues. Leukemia or lymphoma classification depends on which feature is more prominent.	UMLS:C4025181	hp.json		http://purl.obolibrary.org/obo/HP_0005539		
HP:0005532	biolink:PhenotypicFeature	Macrocytic dyserythropoietic anemia		UMLS:C4025183	hp.json	Macrocytic dyserythropoietic anaemia	http://purl.obolibrary.org/obo/HP_0005532		
HP:0030500	biolink:PhenotypicFeature	Yellow/white lesions of the macula		UMLS:C4072987	hp.json		http://purl.obolibrary.org/obo/HP_0030500		
UBERON:3000972	biolink:AnatomicalEntity	head external integument structure	Dermal, epidermal, glandular and pigment structures of the external head integument.		hp.json		http://purl.obolibrary.org/obo/UBERON_3000972		
HP:0030501	biolink:PhenotypicFeature	Macular crystals	Crystalline deposits in the macula.	UMLS:C4072988	hp.json		http://purl.obolibrary.org/obo/HP_0030501		
HP:0005534	biolink:PhenotypicFeature	Transient myeloproliferative syndrome	A unique clonal neoplastic disorder that is linked to trisomy 21, is restricted to neonatal period, and spontaneously regresses. It often has characteristics of megakaryocytic lineage and is associated with GATA1 mutations in myeloblasts.	MSH:C563551|SNOMEDCT_US:450934005|UMLS:C1834582	hp.json	Transient leukaemia of Down syndrome|Transient myeloproliferative disorder|TMD|Transient leukemia of Down syndrome	http://purl.obolibrary.org/obo/HP_0005534		
HP:0030502	biolink:PhenotypicFeature	Retinoschisis	Splitting of the neuroretinal layers of the retina.	UMLS:C0152439|MSH:D041441|SNOMEDCT_US:44268007	hp.json		http://purl.obolibrary.org/obo/HP_0030502		
HP:0005535	biolink:PhenotypicFeature	Exercise-induced hemolysis	A form of hemolytic anemia that can be triggered by exertion.	UMLS:C4025182	hp.json		http://purl.obolibrary.org/obo/HP_0005535		
OBO:MAXO_0000336	biolink:NamedThing	biopsy of bone marrow	Removal of tissue from the bone marrow.		hp.json	bone marrow biopsy	http://purl.obolibrary.org/obo/MAXO_0000336		
OBO:MAXO_0000337	biolink:NamedThing	biopsy of bone tissue	Removal of tissue from the bone tissue.		hp.json	bone tissue biopsy	http://purl.obolibrary.org/obo/MAXO_0000337		
OBO:MAXO_0000334	biolink:NamedThing	biopsy of body of uterus	Removal of tissue from the body of uterus.		hp.json	body of uterus biopsy	http://purl.obolibrary.org/obo/MAXO_0000334		
HP:0005531	biolink:PhenotypicFeature	Biphenotypic acute leukemia	A type of actue leukemia with features characteristic of both the myeloid and lymphoid lineages. These leukemias are for this reason are designated mixed-lineage, hybrid or biphenotypic acute leukemias.	SNOMEDCT_US:128818009|UMLS:C0023464|SNOMEDCT_US:278453007|MSH:D015456	hp.json	Myeloid/lymphoid leukaemia|Acute biphenotypic leukaemia|Myeloid/lymphoid leukemia|Biphenotypic acute leukaemia	http://purl.obolibrary.org/obo/HP_0005531		
OBO:MAXO_0000335	biolink:NamedThing	biopsy of bone element	Removal of tissue from the bone element.		hp.json	bone element biopsy	http://purl.obolibrary.org/obo/MAXO_0000335		
HP:0030507	biolink:PhenotypicFeature	Retinal crystals	Crystalline deposits in the retina.	UMLS:C4072992	hp.json		http://purl.obolibrary.org/obo/HP_0030507		
HP:0030508	biolink:PhenotypicFeature	Retinal cavernous hemangioma		SNOMEDCT_US:312937006|UMLS:C0730304	hp.json	Retinal cavernous haemangioma	http://purl.obolibrary.org/obo/HP_0030508		
HP:0030509	biolink:PhenotypicFeature	Retinal racemose hemangioma		UMLS:C4072993	hp.json	Retinal racemose haemangioma	http://purl.obolibrary.org/obo/HP_0030509		
OBO:MAXO_0000338	biolink:NamedThing	biopsy of brain	Removal of tissue from the brain.		hp.json	brain biopsy	http://purl.obolibrary.org/obo/MAXO_0000338		
OBO:MAXO_0000339	biolink:NamedThing	biopsy of brainstem	Removal of tissue from the brainstem.		hp.json	brainstem biopsy	http://purl.obolibrary.org/obo/MAXO_0000339		
OBO:MAXO_0000361	biolink:NamedThing	biopsy of fallopian tube	Removal of tissue from the fallopian tube.		hp.json	fallopian tube biopsy	http://purl.obolibrary.org/obo/MAXO_0000361		
OBO:MAXO_0000362	biolink:NamedThing	biopsy of frontal lobe	Removal of tissue from the frontal lobe.		hp.json	frontal lobe biopsy	http://purl.obolibrary.org/obo/MAXO_0000362		
OBO:MAXO_0000360	biolink:NamedThing	biopsy of eye	Removal of tissue from the eye.		hp.json	eye biopsy	http://purl.obolibrary.org/obo/MAXO_0000360		
OBO:MAXO_0000365	biolink:NamedThing	biopsy of gonad	Removal of tissue from the gonad.		hp.json	gonad biopsy	http://purl.obolibrary.org/obo/MAXO_0000365		
OBO:MAXO_0000366	biolink:NamedThing	biopsy of heart	Removal of tissue from the heart.		hp.json	heart biopsy	http://purl.obolibrary.org/obo/MAXO_0000366		
UBERON:0037089	biolink:AnatomicalEntity	wall of orbit		FMA:63144	hp.json	orbit wall	http://purl.obolibrary.org/obo/UBERON_0037089		
OBO:MAXO_0000363	biolink:NamedThing	biopsy of gall bladder	Removal of tissue from the gall bladder.		hp.json	gall bladder biopsy	http://purl.obolibrary.org/obo/MAXO_0000363		
OBO:MAXO_0000364	biolink:NamedThing	biopsy of genitourinary system	Removal of tissue from the genitourinary system.		hp.json	genitourinary system biopsy	http://purl.obolibrary.org/obo/MAXO_0000364		
HP:0005507	biolink:PhenotypicFeature	Hemoglobin Barts	Normal adult hemoglobin is composed of two chains each of alpha and beta globin. Hb Barts (Hemoglobin Barts) is a tetramer with four gamma globin chains, and is essentially pathognomonic for one or another form of alpha thalassemia. Hb Barts has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues.	UMLS:C3539063	hp.json	Haemoglobin Barts|Hb Barts	http://purl.obolibrary.org/obo/HP_0005507		
HP:0005508	biolink:PhenotypicFeature	Monoclonal immunoglobulin M proteinemia	Presence of a monoclonal immunoglobulin M protein in the serum.	UMLS:C0024419|SNOMEDCT_US:190817009|MSH:D008258|SNOMEDCT_US:35562000|SNOMEDCT_US:190818004	hp.json	Waldenstrom macroglobulinemia	http://purl.obolibrary.org/obo/HP_0005508		
UBERON:0001095	biolink:AnatomicalEntity	caudal vertebra	Any vertebral bone that is part of the caudal region of the vertebral column (tail or coccyx).	ZFA:0000326|OpenCyc:Mx4rv9IEzZwpEbGdrcN5Y29ycA|TAO:0000326|NCIT:C32334|MA:0000310|MA:0001420|XAO:0003079|EMAPA:18374|FMA:12527|UMLS:C0223616|galen:CoccygealVertebra	hp.json	coccygeal vertebra|tail vertebra|caudal vertebral bone|caudal vertebra|coccygeal segment|caudal vertebral bone element|fused tail vertebra|coccygea|caudal vertebrae	http://purl.obolibrary.org/obo/UBERON_0001095		uberon_slim|vertebrate_core|pheno_slim
HP:0030514	biolink:PhenotypicFeature	Difficulty adjusting from dark to light		UMLS:C4072996	hp.json		http://purl.obolibrary.org/obo/HP_0030514		
UBERON:0001094	biolink:AnatomicalEntity	sacral vertebra	A vertebra bone that is part of the sacral region of the vertebral column.	EMAPA:18336|MA:0000313|UMLS:C1261045|NCIT:C12853|XAO:0003078|OpenCyc:Mx4rv-ZsXpwpEbGdrcN5Y29ycA|FMA:12526|AAO:0000552|galen:SacralVertebra	hp.json	segment of sacrum|sacral segment	http://purl.obolibrary.org/obo/UBERON_0001094		uberon_slim|pheno_slim
HP:0030515	biolink:PhenotypicFeature	Moderately reduced visual acuity	Moderate reduction of the ability to see defined as visual acuity less than 6/18 (20/60 in US notation; 0.5 in decimal notation) but at least 6/60 (20/200 in US notation; 0.1 in decimal notation).	SNOMEDCT_US:397542006|UMLS:C1301510	hp.json	Moderate visual loss|Moderate visual impairment|Moderate vision loss|Moderate reduction in visual acuity	http://purl.obolibrary.org/obo/HP_0030515		
HP:0005505	biolink:PhenotypicFeature	Refractory anemia		MSH:D000753|SNOMEDCT_US:128845005|UMLS:C0002893	hp.json	Refractory anaemia	http://purl.obolibrary.org/obo/HP_0005505		
HP:0030516	biolink:PhenotypicFeature	Homonymous hemianopia		UMLS:C0271202|SNOMEDCT_US:34063005|MSH:D006423	hp.json	Homonymous hemianopsia	http://purl.obolibrary.org/obo/HP_0030516		
HP:0030517	biolink:PhenotypicFeature	Heteronymous hemianopia		UMLS:C0271207|SNOMEDCT_US:345121001|SNOMEDCT_US:344104004	hp.json	Heteronymous hemianopsia	http://purl.obolibrary.org/obo/HP_0030517		
UBERON:0001096	biolink:AnatomicalEntity	wall of esophagus	An anatomical wall that is part of a esophagus [Automatically generated definition].	MA:0002691|FMA:12611|EMAPA:35326	hp.json	wall of oesophagus|wall of gullet|anatomical wall of oesophagus|anatomical wall of gullet|anatomical wall of esophagus|gullet wall|oesophagus wall|esophagus wall|esophageal wall|oesophagus anatomical wall|gullet anatomical wall|esophagus anatomical wall	http://purl.obolibrary.org/obo/UBERON_0001096		
HP:0005506	biolink:PhenotypicFeature	Chronic myelogenous leukemia	A myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate.	MSH:D015464|SNOMEDCT_US:92818009|DOID:8552|UMLS:C0023473|SNOMEDCT_US:63364005	hp.json	Chronic myeloid leukemia|Chronic myelogenous leukaemia|Chronic myeloid leukaemia|Chronic myelocytic leukaemia|Chronic myelocytic leukemia	http://purl.obolibrary.org/obo/HP_0005506		
UBERON:0001091	biolink:AnatomicalEntity	calcareous tooth	Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food.	MA:0000348|AEO:0000220|NCIT:C12506|UMLS:C0040426|EMAPA:32906|GAID:1260|TAO:0001625|MIAA:0000041|EHDAA2:0004605|XAO:0000431|CALOHA:TS-1055|MESH:D014070|ZFA:0000694|FMA:12516|VHOG:0001733|BTO:0000397|MAT:0000041|EV:0100063|OpenCyc:Mx4rvVjUEZwpEbGdrcN5Y29ycA|EFO:0000839	hp.json	dentine containing tooth|tooth|vertebrate tooth|dental element	http://purl.obolibrary.org/obo/UBERON_0001091		uberon_slim|vertebrate_core|pheno_slim|efo_slim
HP:0030510	biolink:PhenotypicFeature	Combined hamartoma of the retinal pigment epithelium and retina		UMLS:C1862062	hp.json		http://purl.obolibrary.org/obo/HP_0030510		
UBERON:0001090	biolink:AnatomicalEntity	synovial fluid	Joint fluid is a transudate of plasma that is actively secreted by synovial cells.	ENVO:02000039|MA:0002544|GAID:265|UMLS:C0039097|BTO:0001339|ZFA:0005154|galen:SynovialFluid|NCIT:C33718|MESH:D013582|CALOHA:TS-0996|Wikipedia:Synovial_fluid|TAO:0005154|FMA:12277	hp.json	joint fluid|joint fluid	http://purl.obolibrary.org/obo/UBERON_0001090		uberon_slim|vertebrate_core
HP:0030511	biolink:PhenotypicFeature	Bradyopsia	Difficulty in seeing moving objects.	UMLS:C1842073|SNOMEDCT_US:711163009|MSH:C564243	hp.json	Difficulty seeing moving objects	http://purl.obolibrary.org/obo/HP_0030511		
UBERON:0001093	biolink:AnatomicalEntity	vertebral bone 2	The second vertebral bone in the vertebral column.	UMLS:C0004457|GAID:237|OpenCyc:Mx4rv-zaJJwpEbGdrcN5Y29ycA|MA:0001422|ZFA:0001168|EMAPA:19432|MESH:D001368|TAO:0001168|NCIT:C32240|EHDAA:10608|FMA:12520	hp.json	axis (CII)|cervical vertebra 2|second cervical vertebra|axis vertebra|axis|axis [C II]|C2|cervical axis|C2 vertebra|vertebra 2	http://purl.obolibrary.org/obo/UBERON_0001093		uberon_slim|vertebrate_core|pheno_slim
HP:0030512	biolink:PhenotypicFeature	Difficulty adjusting to changes in luminance		UMLS:C4072994	hp.json		http://purl.obolibrary.org/obo/HP_0030512		
HP:0005502	biolink:PhenotypicFeature	Increased red cell osmotic fragility		UMLS:C1849478	hp.json	Increased red cell fragility|Increased erythrocyte osmotic fragility	http://purl.obolibrary.org/obo/HP_0005502		
UBERON:0001092	biolink:AnatomicalEntity	vertebral bone 1	The first vertebral bone in the vertebral column.	MESH:D001270|NCIT:C32239|GAID:236|FMA:12519|MA:0001421|ZFA:0001167|EMAPA:19431|TAO:0001167|AAO:0000709|UMLS:C0004170|EHDAA:10606	hp.json	first cervical vertebra|atlas vertebra|atlas [C I]|atlas (CI)|C1 vertebra|atlas|cervical atlas|vertebra 1|cervical vertebra 1|C1	http://purl.obolibrary.org/obo/UBERON_0001092		uberon_slim|vertebrate_core|pheno_slim
UBERON:3000982	biolink:AnatomicalEntity	tail external integument structure	Dermal, epidermal, glandular and pigment structures of the tail integument.		hp.json		http://purl.obolibrary.org/obo/UBERON_3000982		
HP:0030513	biolink:PhenotypicFeature	Difficulty adjusting from light to dark		UMLS:C4072995	hp.json		http://purl.obolibrary.org/obo/HP_0030513		
OBO:MAXO_0000369	biolink:NamedThing	biopsy of intestine	Removal of tissue from the intestine.		hp.json	intestine biopsy	http://purl.obolibrary.org/obo/MAXO_0000369		
OBO:MAXO_0000367	biolink:NamedThing	biopsy of hypopharynx	Removal of tissue from the hypopharynx.		hp.json	hypopharynx biopsy	http://purl.obolibrary.org/obo/MAXO_0000367		
OBO:MAXO_0000368	biolink:NamedThing	biopsy of hypothalamus	Removal of tissue from the hypothalamus.		hp.json	hypothalamus biopsy	http://purl.obolibrary.org/obo/MAXO_0000368		
HP:0030518	biolink:PhenotypicFeature	Congruous homonymous hemianopia		UMLS:C4072997	hp.json	Congruous hemianopsia	http://purl.obolibrary.org/obo/HP_0030518		
UBERON:0001098	biolink:AnatomicalEntity	incisor tooth	Incisors are the first kind of tooth in heterodont mammals. They are located in the premaxilla above and mandible below. [WP,unvetted].	EHDAA:8047|GAID:1263|NCIT:C32769|MA:0000349|EHDAA:8011|OpenCyc:Mx4rwP1ch5wpEbGdrcN5Y29ycA|EMAPA:32889|MESH:D007180|FMA:12823|BTO:0001741|UMLS:C0021156	hp.json	incisor	http://purl.obolibrary.org/obo/UBERON_0001098		uberon_slim|pheno_slim
HP:0030519	biolink:PhenotypicFeature	Congruous heteronymous hemianopia		UMLS:C4072998	hp.json		http://purl.obolibrary.org/obo/HP_0030519		
OBO:MAXO_0000350	biolink:NamedThing	biopsy of colon	Removal of tissue from the colon.		hp.json	colon biopsy	http://purl.obolibrary.org/obo/MAXO_0000350		
OBO:MAXO_0000351	biolink:NamedThing	biopsy of colorectum	Removal of tissue from the colorectum.		hp.json	colorectum biopsy	http://purl.obolibrary.org/obo/MAXO_0000351		
UBERON:0037094	biolink:AnatomicalEntity	wall of common carotid artery		FMA:66284	hp.json	common carotid arterial wall	http://purl.obolibrary.org/obo/UBERON_0037094		
OBO:MAXO_0000354	biolink:NamedThing	biopsy of dorsal plus ventral thalamus	Removal of tissue from the dorsal plus ventral thalamus.		hp.json	dorsal plus ventral thalamus biopsy	http://purl.obolibrary.org/obo/MAXO_0000354		
OBO:MAXO_0000355	biolink:NamedThing	biopsy of duodenum	Removal of tissue from the duodenum.		hp.json	duodenum biopsy	http://purl.obolibrary.org/obo/MAXO_0000355		
OBO:MAXO_0000352	biolink:NamedThing	biopsy of dermis	Removal of tissue from the dermis.		hp.json	dermis biopsy	http://purl.obolibrary.org/obo/MAXO_0000352		
OBO:MAXO_0000353	biolink:NamedThing	biopsy of diaphragm	Removal of tissue from the diaphragm.		hp.json	diaphragm biopsy	http://purl.obolibrary.org/obo/MAXO_0000353		
HP:0030520	biolink:PhenotypicFeature	Binasal hemianopia		MSH:D006423|UMLS:C0271208|SNOMEDCT_US:87278000	hp.json		http://purl.obolibrary.org/obo/HP_0030520		
HP:0005518	biolink:PhenotypicFeature	Increased mean corpuscular volume	Larger than normal size of erythrocytes.	UMLS:C0855791	hp.json	Increased MCV|Erythrocyte macrocytosis	http://purl.obolibrary.org/obo/HP_0005518		
UBERON:0013069	biolink:AnatomicalEntity	popliteal area	A depression on the ventral side of the femur, at the knee joint, between the condyles.	FMA:22525|NCIT:C103222	hp.json	popliteal region|popliteal fossa|popliteal space|knee pit	http://purl.obolibrary.org/obo/UBERON_0013069		
HP:0030525	biolink:PhenotypicFeature	Moderate constriction of peripheral visual field	Peripheral visual field constriction with 20-49 degrees binocular visual field preserved.	UMLS:C4073002	hp.json	Moderate peripheral visual field loss	http://purl.obolibrary.org/obo/HP_0030525		
UBERON:0001084	biolink:AnatomicalEntity	skin of head	A zone of skin that is part of a head [Automatically generated definition].	NCIT:C52757|UMLS:C0205029|FMA:12166|MA:0000582|FMA:24756|SCTID:181484006	hp.json	head zone of skin|zone of skin of adult head|adult head zone of skin|head skin|zone of skin of head	http://purl.obolibrary.org/obo/UBERON_0001084		
UBERON:0001083	biolink:AnatomicalEntity	myocardium of ventricle	Muscular layer of the cardiac ventricle composed of a compact myocardial layer surrounding the trabecular layer.	SCTID:192084000|ZFA:0005061|EFO:0003088|TAO:0005061|FMA:12151|EMAPA:32748|VHOG:0000604|MA:0000082	hp.json	ventricular myocardium|ventricle myocardium|ventricle cardiac muscle	http://purl.obolibrary.org/obo/UBERON_0001083		vertebrate_core|pheno_slim|efo_slim
HP:0030526	biolink:PhenotypicFeature	Severe constriction of peripheral visual field	Peripheral visual field constriction with 10-19 degrees central field preserved.	UMLS:C4073003	hp.json	Severe peripheral visual field loss	http://purl.obolibrary.org/obo/HP_0030526		
HP:0030527	biolink:PhenotypicFeature	Very severe constriction of peripheral visual field	Peripheral visual field constriction with <10 degrees central field preserved.	UMLS:C4073004	hp.json	Very severe peripheral visual field loss	http://purl.obolibrary.org/obo/HP_0030527		
UBERON:0001085	biolink:AnatomicalEntity	skin of trunk	A zone of skin that is part of a trunk [Automatically generated definition].	NCIT:C12295|UMLS:C0205031|FMA:12167|SCTID:181489001|FMA:23093|MA:0000517|EMAPA:37278	hp.json	torso zone of skin|trunk zone of skin|zone of skin of trunk|trunk skin|zone of skin of torso	http://purl.obolibrary.org/obo/UBERON_0001085		
HP:0030528	biolink:PhenotypicFeature	Paracentral scotoma		SNOMEDCT_US:64418005|UMLS:C0271197|MSH:D012607	hp.json		http://purl.obolibrary.org/obo/HP_0030528		
HP:0005517	biolink:PhenotypicFeature	T-cell lymphoma/leukemia	A type of T-cell lymphoma in which cancerous T-cells may present in the blood (leukemia), lymph nodes (lymphoma), skin or in multiple areas.	UMLS:C4025186	hp.json		http://purl.obolibrary.org/obo/HP_0005517		
UBERON:0001080	biolink:AnatomicalEntity	postzygapophysis	Paired processes at the caudal end of the neural arch. The articular facets of the postzygapophyses face lateroventrally and articulate with the dorsomedially facing facets of the prezygapophyses of the succeeding vertebra.	EMAPA:35918|AAO:0000702|ZFA:0000681|MA:0001451|FMA:11954|TAO:0000681	hp.json	processus obliquus posterior|processus articularis inferior|caudal articular process of vertebra|vertebra caudal articular process|neural postzygopophyses|neural postzygapophyses|neural postzygopophysis|processus articularis inferior vertebrae|zygapophysis inferior|neural postzygapophysis|inferior articular process of vertebra|postzygapophysis	http://purl.obolibrary.org/obo/UBERON_0001080		vertebrate_core|pheno_slim
HP:0030521	biolink:PhenotypicFeature	Bitemporal hemianopia		MSH:D006423|SNOMEDCT_US:61917005|UMLS:C0221184	hp.json		http://purl.obolibrary.org/obo/HP_0030521		
HP:0005510	biolink:PhenotypicFeature	Transient erythroblastopenia	A transient reduction in the number of erythroblasts in the circulation.	UMLS:C4082199	hp.json	Transient decrease in blood erythrocyte number	http://purl.obolibrary.org/obo/HP_0005510		
HP:0005511	biolink:PhenotypicFeature	Heinz body anemia	Anemia characterized by abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells.	MSH:C563030|UMLS:C0700299	hp.json	Heinz body anaemia	http://purl.obolibrary.org/obo/HP_0005511		
HP:0030522	biolink:PhenotypicFeature	Mild constriction of peripheral visual field	A diminution of the peripheral visual field whereby at least 50 degrees of central field are preserved in all meridians.	UMLS:C4072999	hp.json	Mild peripheral visual field loss	http://purl.obolibrary.org/obo/HP_0030522		
UBERON:0001082	biolink:AnatomicalEntity	epicardium of ventricle	An epicardial layer that lines a cardiac ventricle.	FMA:12150|ZFA:0005058|TAO:0005058	hp.json	ventricular epicardium|cardiac ventricle epicardium	http://purl.obolibrary.org/obo/UBERON_0001082		vertebrate_core
HP:0030523	biolink:PhenotypicFeature	obsolete Peripheral visual field constriction with 40-50 degrees central field preserved			hp.json		http://purl.obolibrary.org/obo/HP_0030523		
HP:0005512	biolink:PhenotypicFeature	Impaired neutrophil killing of staphylococci	A reduction in the ability of neutrophils to kill the gram-positive bacteria, staphylococcus, which is commonly known as staph.	UMLS:C4025188	hp.json		http://purl.obolibrary.org/obo/HP_0005512		
UBERON:0001081	biolink:AnatomicalEntity	endocardium of ventricle	Endocardium that is part of the cardiac ventricle.	VHOG:0000607|MA:0000079|EMAPA:32747|TAO:0002247|SCTID:192172004|ZFA:0001615|FMA:12148	hp.json	endocardium of ventricle of heart|heart ventricle endocardium|endocardium of heart ventricle|ventricle endocardium|lower chamber of heart endocardium|ventricular endocardium|ventricle of heart endocardium|cardiac ventricle endocardium|endocardium of cardiac ventricle|endocardium of lower chamber of heart|ventricle endocardial tissue	http://purl.obolibrary.org/obo/UBERON_0001081		vertebrate_core|pheno_slim
HP:0030524	biolink:PhenotypicFeature	obsolete Peripheral visual field constriction with 30-39 degrees central field preserved			hp.json		http://purl.obolibrary.org/obo/HP_0030524		
HP:0005513	biolink:PhenotypicFeature	Increased megakaryocyte count	Increased megakaryocyte number, i.e., of platelet precursor cells, present in the bone marrow.	UMLS:C4025187	hp.json		http://purl.obolibrary.org/obo/HP_0005513		
OBO:MAXO_0000358	biolink:NamedThing	biopsy of endometrium	Removal of tissue from the endometrium.		hp.json	endometrium biopsy	http://purl.obolibrary.org/obo/MAXO_0000358		
OBO:MAXO_0000359	biolink:NamedThing	biopsy of esophagus	Removal of tissue from the esophagus.		hp.json	esophagus biopsy	http://purl.obolibrary.org/obo/MAXO_0000359		
OBO:MAXO_0000356	biolink:NamedThing	biopsy of endocardium	Removal of tissue from the endocardium.		hp.json	endocardium biopsy	http://purl.obolibrary.org/obo/MAXO_0000356		
OBO:MAXO_0000357	biolink:NamedThing	biopsy of endocrine pancreas	Removal of tissue from the endocrine pancreas.		hp.json	endocrine pancreas biopsy	http://purl.obolibrary.org/obo/MAXO_0000357		
UBERON:0001088	biolink:AnatomicalEntity	urine	Excretion that is the output of a kidney.	CALOHA:TS-1092|GAID:1189|MIAA:0000058|galen:Urine|NCIT:C13283|EFO:0001939|EMAPA:36554|OpenCyc:Mx4rvVjGppwpEbGdrcN5Y29ycA|UMLS:C0042036|BTO:0001419|MA:0002545|FMA:12274|MESH:D014556|MAT:0000058|ENVO:00002047	hp.json		http://purl.obolibrary.org/obo/UBERON_0001088		efo_slim|uberon_slim|pheno_slim
HP:0030529	biolink:PhenotypicFeature	Ring scotoma		UMLS:C0438434|SNOMEDCT_US:129625005|MSH:D012607	hp.json		http://purl.obolibrary.org/obo/HP_0030529		
UBERON:0001087	biolink:AnatomicalEntity	pleural fluid	Transudate contained in the pleural cavity.	FMA:12273|MA:0002532|MAT:0000500|Wikipedia:Pleural_fluid|ncithesaurus:Pleural_Fluid|BTO:0003080	hp.json		http://purl.obolibrary.org/obo/UBERON_0001087		uberon_slim
UBERON:0001089	biolink:AnatomicalEntity	sweat	Secretion produced by a sweat gland.	BTO:0001254|MA:0002539|GAID:1172|FMA:12275|NCIT:C13280|ENVO:02000025|MESH:D013542|UMLS:C0038984|OpenCyc:Mx4rvVjJtZwpEbGdrcN5Y29ycA	hp.json	skin exudate	http://purl.obolibrary.org/obo/UBERON_0001089		uberon_slim|pheno_slim
HP:0005565	biolink:PhenotypicFeature	Reduced renal corticomedullary differentiation	Reduced differentiation between renal cortex and medulla on diagnostic imaging.	UMLS:C3807131	hp.json	Loss of definition of corticomedullary differentiation	http://purl.obolibrary.org/obo/HP_0005565		
HP:0005567	biolink:PhenotypicFeature	Renal magnesium wasting	High urine magnesium in the presence of hypomagnesemia.	MSH:C537152|UMLS:C1835171	hp.json		http://purl.obolibrary.org/obo/HP_0005567		
HP:0005561	biolink:PhenotypicFeature	Abnormality of bone marrow cell morphology	An anomaly of the form or number of cells in the bone marrow.	SNOMEDCT_US:127035006|UMLS:C4021634|MSH:D001855|UMLS:C0005956	hp.json	Bone marrow disease|Anomaly of the bone marrow cells	http://purl.obolibrary.org/obo/HP_0005561		
HP:0005562	biolink:PhenotypicFeature	Multiple renal cysts	The presence of many cysts in the kidney.	UMLS:C0431718|SNOMEDCT_US:253883006	hp.json	Multiple kidney cysts	http://purl.obolibrary.org/obo/HP_0005562		
HP:0005563	biolink:PhenotypicFeature	Decreased numbers of nephrons	A reduction in the count of nephrons per kidney.	UMLS:C2673888|UMLS:C1841994	hp.json	Oligonephronia|Decreased numbers of glomeruli	http://purl.obolibrary.org/obo/HP_0005563		
HP:0005564	biolink:PhenotypicFeature	Absence of renal corticomedullary differentiation	A lack of differentiation between renal cortex and medulla on diagnostic imaging.	UMLS:C1849765	hp.json	Absent renal corticomedullary differentiation|Loss of corticomedullary differentiation	http://purl.obolibrary.org/obo/HP_0005564		
HP:0005560	biolink:PhenotypicFeature	Imbalanced hemoglobin synthesis	Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia.	UMLS:C4025177	hp.json	Imbalanced Hb synthesis|Imbalanced haemoglobin synthesis	http://purl.obolibrary.org/obo/HP_0005560		
HP:0005576	biolink:PhenotypicFeature	Tubulointerstitial fibrosis	A progressive detrimental connective tissue deposition (fibrosis) on the kidney parenchyma involving the tubules and interstitial tissue of the kidney. Tubulointerstitial injury in the kidney is complex, involving a number of independent and overlapping cellular and molecular pathways, with renal interstitial fibrosis and tubular atrophy (IF/TA) as the final common pathway. However, IF and TA are separable, as shown by the profound TA in renal artery stenosis, which characteristically has little or no fibrosis (or inflammation). For new annotations it is preferable to annotate to the specific HPO terms for Renal interstitial lfibrosis and/or Renal tubular atrophy.	UMLS:C1969372	hp.json	Tubulointerstitial scarring|Tubulointerstitial renal fibrosis	http://purl.obolibrary.org/obo/HP_0005576		
HP:0005579	biolink:PhenotypicFeature	Impaired renal ltubular reabsorption of chloride	Any impairment of reabsorption of chloride by the kidney in order to not lose too much chloride in the urine.	UMLS:C1846349	hp.json	Impaired reabsorption of Cl|Impaired reabsorption of Cl-	http://purl.obolibrary.org/obo/HP_0005579		
HP:0005572	biolink:PhenotypicFeature	Decreased renal tubular phosphate excretion		UMLS:C1968899	hp.json		http://purl.obolibrary.org/obo/HP_0005572		
HP:0005574	biolink:PhenotypicFeature	Non-acidotic proximal tubulopathy	A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption without bicarbonate loss.	UMLS:C4025176	hp.json		http://purl.obolibrary.org/obo/HP_0005574		
HP:0005575	biolink:PhenotypicFeature	Hemolytic-uremic syndrome	A thrombotic microangiopathy with presence of non-immune, intravascular hemolytic anemia, thrombocytopenia and acute kidney injury. A vicious cycle of complement activation, endothelial cell damage, platelet activation, and thrombosis is the hallmark of the disease.	UMLS:C0019061|MSH:D006463|SNOMEDCT_US:111407006	hp.json	Hemolytic uremic syndrome	http://purl.obolibrary.org/obo/HP_0005575		
HP:0005571	biolink:PhenotypicFeature	Increased renal tubular phosphate reabsorption		UMLS:C1968910	hp.json	Increased percent tubular reabsorption of phosphorus	http://purl.obolibrary.org/obo/HP_0005571		
HP:0005547	biolink:PhenotypicFeature	Myeloproliferative disorder	Proliferation (excess production) of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential.	SNOMEDCT_US:414794006|SNOMEDCT_US:425333006|UMLS:C0027022|MSH:D009196	hp.json		http://purl.obolibrary.org/obo/HP_0005547		
HP:0005548	biolink:PhenotypicFeature	Megakaryocytopenia	A reduced count of megakaryocytes.	UMLS:C1858312	hp.json		http://purl.obolibrary.org/obo/HP_0005548		
HP:0005549	biolink:PhenotypicFeature	obsolete Congenital neutropenia			hp.json		http://purl.obolibrary.org/obo/HP_0005549		
HP:0005543	biolink:PhenotypicFeature	Reduced protein C activity	An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein C. Protein C is activated to protein Ca by thrombin bound to thrombomodulin. Activated protein C degrades factors VIIIa and Va.	SNOMEDCT_US:76407009|UMLS:C0398625|MSH:D020151	hp.json	Protein C deficiency	http://purl.obolibrary.org/obo/HP_0005543		
HP:0005546	biolink:PhenotypicFeature	Increased red cell osmotic resistance		UMLS:C1858628	hp.json		http://purl.obolibrary.org/obo/HP_0005546		
PR:P47989	biolink:Protein	xanthine dehydrogenase/oxidase (human)	A xanthine dehydrogenase/oxidase that is encoded in the genome of human.	UniProtKB:P47989	hp.json	XDH|XDHA|hXDH	http://purl.obolibrary.org/obo/PR_P47989		
OBO:MAXO_0000326	biolink:NamedThing	biopsy of head	Removal of tissue from the head.		hp.json	head biopsy	http://purl.obolibrary.org/obo/MAXO_0000326		
HP:0005540	biolink:PhenotypicFeature	Red blood cell keratocytosis	A form of poikilocytosis in which the abnormally shaped erythrocytes have notches that results in projections that look like horns.	UMLS:C4021635	hp.json	RBC keratocytosis|Distorted red blood cells resembling keratocytes	http://purl.obolibrary.org/obo/HP_0005540		
HP:0005541	biolink:PhenotypicFeature	Congenital agranulocytosis	Congenital onset of a marked decrease in the number of granulocytes.	SNOMEDCT_US:89655007|MSH:C537592|UMLS:C1853118	hp.json		http://purl.obolibrary.org/obo/HP_0005541		
HP:0005542	biolink:PhenotypicFeature	Prolonged whole-blood clotting time	An abnormal prolongation (delay) in the time required by whole blood to produce a visible clot.	UMLS:C0151563	hp.json	Prolonged clotting time	http://purl.obolibrary.org/obo/HP_0005542		
OBO:MAXO_0000329	biolink:NamedThing	biopsy of adrenal cortex	Removal of tissue from the adrenal cortex.		hp.json	adrenal cortex biopsy	http://purl.obolibrary.org/obo/MAXO_0000329		
OBO:MAXO_0000327	biolink:NamedThing	biopsy of abdomen	Removal of tissue from the abdomen.		hp.json	abdomen biopsy	http://purl.obolibrary.org/obo/MAXO_0000327		
OBO:MAXO_0000328	biolink:NamedThing	biopsy of adipose tissue	Removal of tissue from the adipose tissue.		hp.json	adipose tissue biopsy	http://purl.obolibrary.org/obo/MAXO_0000328		
HP:0005558	biolink:PhenotypicFeature	Chronic leukemia	A slowly progressing leukemia characterized by a clonal (malignant) proliferation of maturing and mature myeloid cells or mature lymphocytes. When the clonal cellular population is composed of myeloid cells, the process is called chronic myelogenous leukemia. When the clonal cellular population is composed of lymphocytes, it is classified as chronic lymphocytic leukemia, hairy cell leukemia, or T-cell large granular lymphocyte leukemia.	SNOMEDCT_US:128933000|UMLS:C4280478|UMLS:C1279296|SNOMEDCT_US:92812005	hp.json	Chronic leukaemia|Chronic blood cancer	http://purl.obolibrary.org/obo/HP_0005558		
HP:0005559	biolink:PhenotypicFeature	Abnormality of the kinin-kallikrein system		UMLS:C4025178	hp.json		http://purl.obolibrary.org/obo/HP_0005559		
GO:0033371	biolink:BiologicalProcess	T cell secretory granule organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule in a T cell. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.		hp.json	T lymphocyte secretory granule organization|T cell secretory granule organisation|T-cell secretory granule organization|T cell secretory granule organization and biogenesis|T-lymphocyte secretory granule maturation|T-lymphocyte secretory granule organization	http://purl.obolibrary.org/obo/GO_0033371		
HP:0005556	biolink:PhenotypicFeature	Abnormality of the metopic suture	The frontal suture divides the two halves of the frontal bone of the skull in infants and children and generally undergoes fusion by the age of six. A persistent frontal suture is referred to as a "metopic suture".	UMLS:C4025180	hp.json		http://purl.obolibrary.org/obo/HP_0005556		
HP:0005557	biolink:PhenotypicFeature	Abnormal zygomatic arch morphology	An abnormality of the zygomatic arch, also known as the cheek bone.	UMLS:C4025179	hp.json	Anomaly of the malar arch|Abnormality of the malar arch|Malformation of the zygomatic arch|Deformity of the zygomatic arch|Abnormality of the zygomatic arch|Malformation of the malar arch|Anomaly of the zygomatic arch|Deformity of the malar arch	http://purl.obolibrary.org/obo/HP_0005557		
HP:0005550	biolink:PhenotypicFeature	Chronic lymphatic leukemia	A chronic lymphocytic/lymphatic/lymphoblastic leukemia (CLL) is a neoplastic disease characterized by proliferation and accumulation (blood, marrow and lymphoid organs) of morphologically mature but immunologically dysfunctional lymphocytes. A CLL is always a B-cell lymphocytic leukemia as there are no reports of cases of T-cell lymphocytic leukemias.	SNOMEDCT_US:277473004|UMLS:C0023434|SNOMEDCT_US:92814006|SNOMEDCT_US:51092000|MSH:D015451	hp.json	Chronic lymphocytic leukemia|Chronic lymphatic leukaemia|Chronic lymphocytic leukaemia	http://purl.obolibrary.org/obo/HP_0005550		
CL:3000000	biolink:Cell	ciliated epithelial cell of esophagus	A ciliated epithelial cell of the esophagus.		hp.json		http://purl.obolibrary.org/obo/CL_3000000		
CHEBI:58419	biolink:ChemicalSubstance	4-hydroxy-L-proline zwitterion	The amino acid zwitterion formed from 4-hydroxy-L-proline. It is the major microspecies present at pH 7.3.		hp.json	4-hydroxy-L-proline|(2S)-4-hydroxypyrrolidinium-2-carboxylate	http://purl.obolibrary.org/obo/CHEBI_58419		3_STAR
UBERON:0003692	biolink:AnatomicalEntity	acromioclavicular joint	Any joint connecting the acromonion of the scapula and clavicle.	UMLS:C0001208|FMA:25898|MESH:D000173|GAID:249|OpenCyc:Mx4rwHhmSJwpEbGdrcN5Y29ycA|NCIT:C32047	hp.json	acromioclavicular articulation|scapuloclavicular articulation|articulatio acromioclavicularis	http://purl.obolibrary.org/obo/UBERON_0003692		
UBERON:0003693	biolink:AnatomicalEntity	retroperitoneal space	Anatomical space in the abdominal cavity behind (retro) the peritoneum. It has no specific delineating anatomical structures. Organs are retroperitoneal if they only have peritoneum on their anterior side.	GAID:25|NCIT:C12298|MESH:D012187|FMA:15080|CALOHA:TS-2337|EFO:0002806|UMLS:C0035359	hp.json	spatium retroperitoneale|retroperitoneum	http://purl.obolibrary.org/obo/UBERON_0003693		pheno_slim|efo_slim
UBERON:0003690	biolink:AnatomicalEntity	fused sacrum	A collection of sacral vertebrae in the sacral region that are fused and part of the bony pelvis.	GAID:241|galen:Sacrum|NCIT:C33508|FMA:16202|CALOHA:TS-2201|OpenCyc:Mx4rvmBKnJwpEbGdrcN5Y29ycA|MESH:D012447|EFO:0003071	hp.json	sacrum|sacral bone|sacrum [sacral vertebrae I - V]|os sacrum [vertebrae sacrales I - V]|os sacrum|sacrum [sacral vertebrae I-V]	http://purl.obolibrary.org/obo/UBERON_0003690		pheno_slim|efo_slim
UBERON:0003691	biolink:AnatomicalEntity	epidural space	The outermost part of the spinal canal. It is the space within the canal (formed by the surrounding vertebrae) lying outside the dura mater.	FMA:71228|MESH:D004824|GAID:243	hp.json	epidural cavity|cavum extradurale|spatium epidurale|extradural space|cavum epidurale|spatium extradurale	http://purl.obolibrary.org/obo/UBERON_0003691		
UBERON:0001037	biolink:AnatomicalEntity	strand of hair	A filament, mostly protein, that grows from follicles found in the dermis[WP].	CALOHA:TS-0430|GAID:71|MIAA:0000160|MA:0000155|UMLS:C0018494|FMA:53667|OpenCyc:Mx4rvVjOX5wpEbGdrcN5Y29ycA-Mp88EdaAAACgycbRww|EV:0100157|VHOG:0001191|BTO:0001501|NCIT:C32705|EMAPA:18769|MAT:0000160|MESH:D006197|EFO:0000958	hp.json	quill|fur|coat hair|coat/ hair|whisker|setulae|vibrissa|microchaeta|hair	http://purl.obolibrary.org/obo/UBERON_0001037		pheno_slim|efo_slim|uberon_slim
UBERON:0003698	biolink:AnatomicalEntity	subtalar joint	A joint of the pes that connects the talus and the calcaneus.	NCIT:C33653|GAID:260|UMLS:C0038593|MESH:D013380|FMA:35198	hp.json	talocalcaneal joint|subtalar joint|articulatio talocalcanea|talocalcaneal articulation|articulatio subtalaris	http://purl.obolibrary.org/obo/UBERON_0003698		
UBERON:0003699	biolink:AnatomicalEntity	pubic symphysis	The firm fibrocartilaginous joint in the median plane between the two opposing surfaces of the pubic bones, which are united by an interpubic disc of fibrocartilage as well as the superior and arcuate pubic ligaments.	GAID:267|NCIT:C33425|MESH:D011631|EMAPA:37940|OpenCyc:Mx4rwGw9npwpEbGdrcN5Y29ycA|UMLS:C0034015|AAO:0000769|FMA:16950	hp.json	symphysis pubica|interpubic articulation|symphysis pubis|symphysis pubis|symphysis pubis|symphisis pubis	http://purl.obolibrary.org/obo/UBERON_0003699		organ_slim|pheno_slim
UBERON:0001033	biolink:AnatomicalEntity	gustatory system	The sensory system for the sense of taste.	Wikipedia:Gustatory_system|ZFA:0001101|AAO:0010577|TAO:0001101|EFO:0000830|SCTID:423940004|XAO:0003197|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2889|MAT:0000275|FMA:7194|NLXANAT:090803|MIAA:0000275|BILA:0000143|MA:0002446	hp.json	gustatory organ system|taste system	http://purl.obolibrary.org/obo/UBERON_0001033		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0003696	biolink:AnatomicalEntity	metatarsophalangeal joint	The metatarsophalangeal articulations are the joints between the metatarsal bones of the foot and the proximal bones of the toes . They are condyloid joints meaning an elliptical or rounded surface (of the metatarsal bones) come close to the shallow cavities (of the proximal phalanges). The ligaments are the plantar and two collateral.	galen:MetatarsoPhalangealJoint|NCIT:C33108|GAID:258|MESH:D008683|FMA:35222|UMLS:C0025589|OpenCyc:Mx4rwCtS0pwpEbGdrcN5Y29ycA	hp.json	articulationes metatarsophalangeae|metatarsophalangeal|metatarsalphalangeal joint|metatarsal joint|metatarsophalangeal articulation|metatarsal-phalangeal joint	http://purl.obolibrary.org/obo/UBERON_0003696		
UBERON:0001032	biolink:AnatomicalEntity	sensory system	Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information.	MA:0002442|AAO:0000555|FMA:75259|BAMS:SEN|ZFA:0000282|NLXANAT:090816|XAO:0003194|EMAPA:16192|TAO:0000282|MAT:0000031|FBbt:00007692|Wikipedia:Sensory_system|VHOG:0001674|BILA:0000099|EFO:0000805|MIAA:0000031|EHDAA2:0003094	hp.json	sensory subsystem|sense organ subsystem|sense organs|sensory organ system|sensory systems|organa sensuum|set of sense organs|organa sensuum|sense organs set|organa sensuum	http://purl.obolibrary.org/obo/UBERON_0001032		efo_slim|uberon_slim|vertebrate_core
UBERON:0003697	biolink:AnatomicalEntity	abdominal wall	The tissues that surround the organs that are present within the abdominal cavity. The abdominal wall tissue is composed of layers of fat, parietal peritoneum, fascia, and muscles.	FMA:10429|Wikipedia:Abdominal_wall|MESH:D034861|FMA:259054|GAID:26|SCTID:181613000|NCIT:C77608|EMAPA:37064|UMLS:C0836916	hp.json	layers of the abdominal wall|paries abdominalis|abdominal wall proper|layers of the abdominal wall|paries abdominalis|paries abdominalis|wall of abdomen|paries abdominalis|wall of abdomen proper	http://purl.obolibrary.org/obo/UBERON_0003697		pheno_slim
UBERON:0003694	biolink:AnatomicalEntity	atlanto-axial joint	The Atlanto-axial joint is of a complicated nature, comprising no fewer than four distinct joints. There is a pivot articulation between the odontoid process of the axis and the ring formed by the anterior arch and the transverse ligament of the atlas.	NCIT:C32157|MESH:D001268|GAID:250|FMA:25524|UMLS:C0004168|OpenCyc:Mx4rwUUIHpwpEbGdrcN5Y29ycA	hp.json	median atlanto-axial joint|lateral atlanto-axial joint|articulatio atlantoepistrophica|atlanto axial joint|atlantoaxial|atlantoaxial joint|articulatio atlantoaxialis	http://purl.obolibrary.org/obo/UBERON_0003694		pheno_slim
OBO:hp#uk_spelling	biolink:NamedThing	UK spelling			hp.json		http://purl.obolibrary.org/obo/hp#uk_spelling		
UBERON:0003695	biolink:AnatomicalEntity	metacarpophalangeal joint	The metacarpophalangeal joints (MCP) are of the condyloid kind, formed by the reception of the rounded heads of the metacarpal bones into shallow cavities on the proximal ends of the first phalanges, with the exception of that of the thumb, which presents more of the characters of a ginglymoid joint. Arthritis of the MCP is a distinguishing feature of Rheumatoid Arthritis, as opposed to the distal interphalangeal joint in osteoarthritis. [WP,unvetted].	MA:0000453|FMA:35246|galen:MetacarpoPhalangealJoint|MESH:D008662|UMLS:C0025525|OpenCyc:Mx4rwNt8wJwpEbGdrcN5Y29ycA|NCIT:C33106|GAID:255|EMAPA:19302	hp.json	MP joint|metacarpal phalangeal joint|metacarpal joint|metacarpo-phalangeal joint|knuckle|knuckles|carpometacarpophalangeal joint|articulationes metacarpophalangeae	http://purl.obolibrary.org/obo/UBERON_0003695		pheno_slim
GO:1901859	biolink:BiologicalProcess	negative regulation of mitochondrial DNA metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial DNA metabolic process.		hp.json	downregulation of mtDNA metabolism|downregulation of mtDNA metabolic process|downregulation of mitochondrial DNA metabolism|down regulation of mtDNA metabolism|inhibition of mtDNA metabolic process|down regulation of mitochondrial DNA metabolism|down-regulation of mitochondrial DNA metabolic process|negative regulation of mtDNA metabolism|down-regulation of mtDNA metabolism|negative regulation of mtDNA metabolic process|down-regulation of mtDNA metabolic process|down-regulation of mitochondrial DNA metabolism|negative regulation of mitochondrial DNA metabolism|down regulation of mitochondrial DNA metabolic process|inhibition of mtDNA metabolism|down regulation of mtDNA metabolic process|inhibition of mitochondrial DNA metabolism|inhibition of mitochondrial DNA metabolic process|downregulation of mitochondrial DNA metabolic process	http://purl.obolibrary.org/obo/GO_1901859		
UBERON:0001019	biolink:AnatomicalEntity	nerve fasciculus	A slender neuron projection bundle[FBbt]; A bundle of anatomical fibers, as of muscle or nerve (American Heritage Dictionary 4th ed).	FMA:12235|Wikipedia:Nervous_system_fascicle|TGMA:0000088|UMLS:C1185741|NCIT:C32586|BTO:0002191|EMAPA:36605|BIRNLEX:872	hp.json	nerve fasciculus|fasciculus|nerve fiber tract|fascicle|neural fasciculus|nerve bundle	http://purl.obolibrary.org/obo/UBERON_0001019		uberon_slim
UBERON:0001018	biolink:AnatomicalEntity	axon tract	A group of axons linking two or more neuropils and having a common origin, termination[FBbt].	FMA:83847|EV:0100304|BIRNLEX:1649|FBbt:00005100|NLX:147822	hp.json	tract of neuraxis|tract|nerve tract|neuraxis tract|nerve tract|axonal tract	http://purl.obolibrary.org/obo/UBERON_0001018		cumbo|pheno_slim
GO:1901858	biolink:BiologicalProcess	regulation of mitochondrial DNA metabolic process	Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process.		hp.json	regulation of mtDNA metabolism|regulation of mitochondrial DNA metabolism|regulation of mtDNA metabolic process	http://purl.obolibrary.org/obo/GO_1901858		
CHEBI:22478	biolink:ChemicalSubstance	amino alcohol	An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group.		hp.json	amino alcohols|aminoalcohols|aminoalcohol	http://purl.obolibrary.org/obo/CHEBI_22478		3_STAR
UBERON:0003681	biolink:AnatomicalEntity	masticatory muscle	In humans: Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed).	MA:0003115|UMLS:C0024890|NCIT:C33147|MESH:D008410|FMA:74060|GAID:145	hp.json	jaw muscle|muscle of mastication|musculi masticatorii|musculi masticatorii	http://purl.obolibrary.org/obo/UBERON_0003681		pheno_slim
GO:0060980	biolink:BiologicalProcess	cell migration involved in coronary vasculogenesis	The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0060980		
UBERON:0003682	biolink:AnatomicalEntity	palatal muscle	The muscles of the palate are the glossopalatine, palatoglossus, levator palati(ni), musculus uvulae, palatopharyngeus, and tensor palati(ni).	NCIT:C33247|MESH:D010156|FMA:46726|GAID:151|UMLS:C0030213|EMAPA:37929	hp.json	musculi palati mollis et faucium|musculi palati mollis et faucium|muscle of palate|palatine muscle|palate muscle|palatal muscle	http://purl.obolibrary.org/obo/UBERON_0003682		pheno_slim
GO:0060981	biolink:BiologicalProcess	cell migration involved in coronary angiogenesis	The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels.		hp.json		http://purl.obolibrary.org/obo/GO_0060981		
UBERON:0001020	biolink:AnatomicalEntity	nervous system commissure	Axon tract that crosses the midline of the central nervous system[NIF, modified]. In the context of Drosophila refers to a broad band of axons connecting equivalent neuropils each side of the brain[FBbt].	OpenCyc:Mx4rdBrmE6gOEdudWQACs5b6Bw|TADS:0000201|FMA:83906|UMLS:C1185742|NCIT:C32349|NLX:110|NLXANAT:20090513	hp.json	commissure of neuraxis|neuraxis commissure|white matter commissure|commissure	http://purl.obolibrary.org/obo/UBERON_0001020		cumbo|uberon_slim
GO:0060986	biolink:BiologicalProcess	endocrine hormone secretion	The regulated release of a hormone into the circulatory system.		hp.json		http://purl.obolibrary.org/obo/GO_0060986		
UBERON:0003689	biolink:AnatomicalEntity	sella turcica	The sella turcica is a saddle-shaped depression in the sphenoid bone at the base of the human skull. [WP,unvetted].	MESH:D012658|CALOHA:TS-2342|GAID:231|NCIT:C12497|UMLS:C0036609|FMA:54709	hp.json	turkish saddle|suprasellar|Turkey Chair	http://purl.obolibrary.org/obo/UBERON_0003689		pheno_slim
UBERON:0001028	biolink:AnatomicalEntity	diaphysis of radius	A diaphysis that is part of a radius bone[Automatically generated definition].	FMA:33782|NCIT:C120674	hp.json	body of radius|corpus radii|radial shaft|shaft of radius|radial diaphysis|shaft of radius	http://purl.obolibrary.org/obo/UBERON_0001028		pheno_slim
UBERON:0003687	biolink:AnatomicalEntity	foramen magnum	In anatomy, in the occipital bone, the foramen magnum is one of the several oval or circular apertures in the base of the skull, through which the medulla oblongata (an extension of the spinal cord) enters and exits the skull vault. Apart from the transmission of the medulla oblongata and its membranes, the foramen magnum transmits the Spinal Accessory nerve, vertebral arteries, the anterior and posterior spinal arteries, the membrana tectoria and alar ligaments. [WP,unvetted].	MESH:D005539|EMAPA:37868|FMA:75306|UMLS:C0016519|ZFA:0005387|SCTID:244679008|TAO:0002045|Wikipedia:Foramen_magnum|NCIT:C12495|OpenCyc:Mx4rwOm-FpwpEbGdrcN5Y29ycA|GAID:228|AAO:0010826	hp.json		http://purl.obolibrary.org/obo/UBERON_0003687		vertebrate_core|pheno_slim
UBERON:0001027	biolink:AnatomicalEntity	sensory nerve	A nerve that transmits from sensory receptors on the surface of the body to the central nervous system.	OpenCyc:Mx4rv0GdXpwpEbGdrcN5Y29ycA|FBbt:00005136|Wikipedia:Sensory_nerve|EHDAA2:0003200|FMA:5868|AEO:0000201	hp.json	afferent nerve|nervus sensorius|nervus sensorius	http://purl.obolibrary.org/obo/UBERON_0001027		uberon_slim|pheno_slim
CHEBI:58402	biolink:ChemicalSubstance	5-oxo-L-prolinate	Conjugate base of 5-oxo-L-proline.	Gmelin:675391|Beilstein:4783230|MetaCyc:5-OXOPROLINE	hp.json	5-oxo-L-prolate|5-oxo-L-proline|(2S)-5-oxopyrrolidine-2-carboxylate	http://purl.obolibrary.org/obo/CHEBI_58402		3_STAR
UBERON:0003685	biolink:AnatomicalEntity	cranial suture	Fibrous joint in which the articulating bones or cartilages of the skull are connected by sutural ligaments (scant amount of collagenous dense connective tissue). Examples: sagittal suture, frontal suture.	GAID:211|EMAPA:35263|SCTID:244509003|MA:0001475|FMA:7493|MESH:D003393|Wikipedia:Suture_(joint)	hp.json	sutura|suture of cranium|suture|suture joint of skull|cranium suture	http://purl.obolibrary.org/obo/UBERON_0003685		pheno_slim|uberon_slim
UBERON:0001021	biolink:AnatomicalEntity	nerve	An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures.	AAO:0011070|EHDAA:4657|ZFA:0007009|FBbt:00005105|EMAPA:32815|XAO:0003047|EHDAA:3776|galen:Nerve|EHDAA:2851|NCIT:C12466|SCTID:256864008|TAO:0007009|VHOG:0000901|FMA:65239|BAMS:n|UMLS:C0031119|OpenCyc:Mx4rwP3lkpwpEbGdrcN5Y29ycA|EHDAA2:0003137|NLX:147826|SCTID:244457007|BIRNLEX:1615|BTO:0001027|AEO:0000137|GAID:747|GAID:758|BSA:0000098|EV:0100371|XAO:0000204|MA:0000217|MA:0000228|FMA:65132|UMLS:C0027740|EMAPA:32808|MESH:D010525|CALOHA:TS-0772|Wikipedia:Nervous_system|NCIT:C12768|BTO:0000925	hp.json	peripheral nerve|peripheral nerve|neural subtree|nerves	http://purl.obolibrary.org/obo/UBERON_0001021		vertebrate_core|pheno_slim|human_reference_atlas|uberon_slim
UBERON:0003684	biolink:AnatomicalEntity	abdominal cavity	The part of the ventral body cavity that is within the abdomen proper (excluding the pelvic cavity).	OpenCyc:Mx4rvZR1TJwpEbGdrcN5Y29ycA|GAID:17|MESH:D034841|NCIT:C12664|MA:0003057|galen:AbdominalCavity|EFO:0000213|EMAPA:36505|Wikipedia:Abdominal_cavity|UMLS:C0230168|FMA:12266|SCTID:361294009	hp.json	cavity of compartment of abdomen|cavitas abdominis|cavity of abdominal compartment|cavitas abdominis|space of abdominal compartment|cavitas abdominis	http://purl.obolibrary.org/obo/UBERON_0003684		efo_slim
UBERON:0001008	biolink:AnatomicalEntity	renal system	The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products..	MESH:D014551|BTO:0001244|EV:0100095|SCTID:362204003|CALOHA:TS-1323|MA:0000325|EFO:0000803|TADS:0000162|FMA:7159|EHDAA:5901|EMAPA:17366|galen:UrinaryTract|EHDAA2:0001601|NCIT:C12413|XAO:0000143|Wikipedia:Excretory_system|MAT:0000027|AAO:0010257|BTO:0003092|ZFA:0000163|FBbt:00005056|VHOG:0000723|WBbt:0005736|MIAA:0000027|TAO:0000163|UMLS:C1508753|GAID:391|BILA:0000015	hp.json	renal system|renal/urinary system|systema urinaria|renal or urinary system|excretory system|urinary tract|systema urinarium|urinary system	http://purl.obolibrary.org/obo/UBERON_0001008		efo_slim|uberon_slim|vertebrate_core|pheno_slim
UBERON:0001007	biolink:AnatomicalEntity	digestive system	Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes.	galen:DigestiveSystem|ZFA:0000339|MESH:D004064|TAO:0000339|XAO:0000125|SCTID:278859004|GAID:278|ncithesaurus:Digestive_System|MAT:0000018|Wikipedia:Digestive_system|AAO:0000129|TADS:0000170|BILA:0000082|MA:0002431|MIAA:0000018|WBbt:0005748|CALOHA:TS-1293|EV:0100056|FBbt:00005055|FMA:7152|BTO:0000058|EFO:0000793	hp.json	gut|alimentary system|gastrointestinal system|alimentary tract	http://purl.obolibrary.org/obo/UBERON_0001007		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0001009	biolink:AnatomicalEntity	circulatory system	Organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP].	VHOG:0001248|AAO:0000959|CALOHA:TS-2103|OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA|Wikipedia:Circulatory_system	hp.json	systema cardiovasculare|systema cardiovasculare	http://purl.obolibrary.org/obo/UBERON_0001009		uberon_slim
GO:1901862	biolink:BiologicalProcess	negative regulation of muscle tissue development	Any process that stops, prevents or reduces the frequency, rate or extent of muscle tissue development.		hp.json	down-regulation of muscle tissue development|down regulation of muscle tissue development|inhibition of muscle tissue development|downregulation of muscle tissue development	http://purl.obolibrary.org/obo/GO_1901862		
GO:1901863	biolink:BiologicalProcess	positive regulation of muscle tissue development	Any process that activates or increases the frequency, rate or extent of muscle tissue development.		hp.json	up regulation of muscle tissue development|activation of muscle tissue development|upregulation of muscle tissue development|up-regulation of muscle tissue development	http://purl.obolibrary.org/obo/GO_1901863		
GO:1901860	biolink:BiologicalProcess	positive regulation of mitochondrial DNA metabolic process	Any process that activates or increases the frequency, rate or extent of mitochondrial DNA metabolic process.		hp.json	activation of mtDNA metabolism|upregulation of mtDNA metabolism|upregulation of mitochondrial DNA metabolic process|activation of mitochondrial DNA metabolism|upregulation of mtDNA metabolic process|upregulation of mitochondrial DNA metabolism|activation of mtDNA metabolic process|positive regulation of mtDNA metabolism|up regulation of mtDNA metabolism|positive regulation of mitochondrial DNA metabolism|up-regulation of mitochondrial DNA metabolic process|up regulation of mitochondrial DNA metabolism|up-regulation of mtDNA metabolism|up-regulation of mtDNA metabolic process|up regulation of mitochondrial DNA metabolic process|activation of mitochondrial DNA metabolic process|up-regulation of mitochondrial DNA metabolism|up regulation of mtDNA metabolic process|positive regulation of mtDNA metabolic process	http://purl.obolibrary.org/obo/GO_1901860		
GO:1901861	biolink:BiologicalProcess	regulation of muscle tissue development	Any process that modulates the frequency, rate or extent of muscle tissue development.		hp.json		http://purl.obolibrary.org/obo/GO_1901861		
UBERON:0001015	biolink:AnatomicalEntity	musculature	A subdivision of the muscular system corresponding to a subdisivision of an organism.	TAO:0000548|EFO:0001949|VSAO:0005038|EMAPA:32715|Wikipedia:Muscular_system|BTO:0000887|MA:0000165|WBbt:0005737|UMLS:C0026845|FMA:32558|OpenCyc:Mx4rvVjmr5wpEbGdrcN5Y29ycA|NCIT:C13056|AAO:0011066|ZFA:0000548|EMAPA:35577	hp.json	set of muscles|muscle group|set of skeletal muscles|muscles|muscle system|musculi|musculature|musculature system|muscles set	http://purl.obolibrary.org/obo/UBERON_0001015		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0003679	biolink:AnatomicalEntity	mouth floor	The ventral area of the mouth. In organisms with a tongue, this is the area under the ventral surface of the tongue[ncit, modified].	GAID:1283|FMA:86592|EFO:0001923|EMAPA:37911|NCIT:C54187|MESH:D009060|UMLS:C0026638|CALOHA:TS-2207	hp.json	sublingual region|floor of the oval cavity|floor of oval cavity|floor of mouth	http://purl.obolibrary.org/obo/UBERON_0003679		pheno_slim|efo_slim
UBERON:0001017	biolink:AnatomicalEntity	central nervous system	The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.	XAO:0000215|FBbt:00005094|EMAPA:16754|UMLS:C0927232|MESH:D002490|NCIT:C12438|OpenCyc:Mx4rvzYt3pwpEbGdrcN5Y29ycA|UMLS:C0927232|BIRNLEX:1099|EHDAA2:0000225|AAO:0000090|VHOG:0000293|MAT:0000457|MA:0000167|ZFA:0000012|SCTID:278199004|CALOHA:TS-0150|BTO:0000227|BILA:0000080|GAID:570|TAO:0000012|Wikipedia:Central_nervous_system|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=854|EMAPA:16470|EFO:0000908|EHDAA:828|FMA:55675|EV:0100163|BAMS:CNS	hp.json	systema nervosum centrale|neuraxis|cerebrospinal axis|CNS	http://purl.obolibrary.org/obo/UBERON_0001017		uberon_slim|cumbo|vertebrate_core|pheno_slim|efo_slim
UBERON:0001016	biolink:AnatomicalEntity	nervous system	The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO].	BTO:0001484|EMAPA:16469|CALOHA:TS-1313|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3236|FBbt:00005093|MESH:D009420|SCTID:278196006|GAID:466|MA:0000016|Wikipedia:Nervous_system|OpenCyc:Mx4rvViT_pwpEbGdrcN5Y29ycA|EFO:0000802|NCIT:C12755|XAO:0000177|FMA:7157|ZFA:0000396|MAT:0000026|EHDAA2:0001246|AAO:0000324|BIRNLEX:844|TAO:0000396|WBbt:0005735|UMLS:C0027763|MIAA:0000026|VHOG:0000402|BILA:0000079|EV:0100162|EHDAA:826	hp.json	systema nervosum|nerve net|systema nervosum|neurological system|nerve net	http://purl.obolibrary.org/obo/UBERON_0001016		cumbo|uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0003677	biolink:AnatomicalEntity	tooth root	The part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone.	GAID:1280|MESH:D014092|EMAPA:37975|FMA:55624	hp.json	radix corona|root of tooth|tooth root	http://purl.obolibrary.org/obo/UBERON_0003677		pheno_slim
UBERON:0003674	biolink:AnatomicalEntity	cuspid	A tooth that is typically long and pointed and bearing a single cusp.	NCIT:C32258|UMLS:C0010482|FMA:55636|GAID:1262|MESH:D003481	hp.json	canine tooth|eye teeth|canine teeth|eyeteeth|canine (tooth)|eye tooth|dens caninus|canine eminence|eyetooth|cuspis dentis|canine teeth|caniniform tooth|fang|canine|dogtooth (anatomy)|dentes canini	http://purl.obolibrary.org/obo/UBERON_0003674		pheno_slim
UBERON:0001010	biolink:AnatomicalEntity	diaphysis of ulna	The body of the ulna at its upper part is prismatic in form, and curved so as to be convex behind and lateralward; its central part is straight; its lower part is rounded, smooth, and bent a little lateralward. It tapers gradually from above downward, and has three borders and three surfaces.	NCIT:C120676|FMA:33760	hp.json	ulnar diaphysis|supinator crest|shaft of ulna|shaft of ulna|body of ulna|corpus ulnae	http://purl.obolibrary.org/obo/UBERON_0001010		
UBERON:0003675	biolink:AnatomicalEntity	tooth crown	The portion of the tooth covered by enamel.	NCIT:C32375|MESH:D019228|FMA:55623|UMLS:C0226993|GAID:1275	hp.json	tooth crown|anatomical crown|crown of tooth|crown|corona dentis	http://purl.obolibrary.org/obo/UBERON_0003675		
UBERON:0001013	biolink:AnatomicalEntity	adipose tissue	Portion of connective tissue composed of adipocytes enmeshed in areolar tissue.	UMLS:C0001527|CALOHA:TS-0013|EMAPA:35112|Wikipedia:Adipose_tissue|XAO:0003049|AEO:000020|VHOG:0001284|MAT:0000015|ZFA:0005345|TAO:0002134|SCTID:55603005|AAO:0000001|MIAA:0000015|OpenCyc:Mx4rvVjc_ZwpEbGdrcN5Y29ycA|NCIT:C12472|MESH:D000273|BTO:0001487|galen:FattyTissue|EHDAA2:0003120|MA:0000009|EFO:0000790|EV:0100381|GAID:920|FMA:20110	hp.json	adipose|bodyfat|fatty depot|fat tissue|fat|fatty tissue	http://purl.obolibrary.org/obo/UBERON_0001013		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas|efo_slim
UBERON:0003672	biolink:AnatomicalEntity	dentition	A collection of teeth arranged in some pattern in the mouth or other part of the body. The arrangement may be a simple row, a collection of rows, or a more elaborate structure, such as a toooth whorl.	FMA:75150|GAID:1249|AAO:0000126|UMLS:C0011443|OpenCyc:Mx4rvVi65JwpEbGdrcN5Y29ycA|MESH:D003817|NCIT:C13072	hp.json	dentes|teeth set|collection of teeth|teeth|teeth|set of teeth	http://purl.obolibrary.org/obo/UBERON_0003672		pheno_slim
UBERON:0001012	biolink:AnatomicalEntity	head of radius	The head of the radius has a cylindrical form, and on its upper surface is a shallow cup or fovea for articulation with the capitulum (or capitellum) of the humerus. The circumference of the head is smooth; it is broad medially where it articulates with the radial notch of the ulna, narrow in the rest of its extent, which is embraced by the annular ligament. The deepest point in the fovea is not axi-symmetric with the long axis of the radius, creating a cam effect during pronation and supination[WP].	galen:HeadOfRadius|FMA:33773	hp.json	radial head|caput radii	http://purl.obolibrary.org/obo/UBERON_0001012		pheno_slim
GO:1901879	biolink:BiologicalProcess	regulation of protein depolymerization	Any process that modulates the frequency, rate or extent of protein depolymerization.		hp.json	regulation of protein polymer degradation|regulation of protein polymer catabolism|regulation of protein polymer breakdown|regulation of protein polymer catabolic process	http://purl.obolibrary.org/obo/GO_1901879		
UBERON:0003658	biolink:AnatomicalEntity	hip muscle	Any muscle organ that is part of a hip [Automatically generated definition].	MA:0000657	hp.json	muscle organ of hip|hip muscle organ|muscle organ of hip region|muscle organ of regio coxae|hip region muscle organ|regio coxae muscle organ	http://purl.obolibrary.org/obo/UBERON_0003658		
UBERON:0003659	biolink:AnatomicalEntity	pedal digit muscle	Any muscle organ that is part of a toe [Automatically generated definition].	EMAPA:37333|MA:0000648	hp.json	muscle organ of foot digit|foot digit muscle|foot digit muscle|muscle organ of digit of terminal segment of free lower limb|muscle organ of terminal segment of free lower limb digit|muscle organ of toe|digitus pedis muscle organ|digit of foot muscle organ|digit of terminal segment of free lower limb muscle organ|hind limb digit muscle|muscle organ of digit of foot|muscle organ of digitus pedis|toe muscle organ|terminal segment of free lower limb digit muscle organ|foot digit muscle organ	http://purl.obolibrary.org/obo/UBERON_0003659		
UBERON:2001457	biolink:AnatomicalEntity	postcranial axial cartilage	Cartilage which is part of the axial skeleton.	ZFA:0001457	hp.json		http://purl.obolibrary.org/obo/UBERON_2001457		
UBERON:0003660	biolink:AnatomicalEntity	eyelid muscle	A muscle that attaches to an eyelid.	MA:0000269|UMLS:C1707990|NCIT:C52803	hp.json	blepharon muscle organ|eyelid muscle organ|muscle organ of blepharon|muscle organ of eyelid	http://purl.obolibrary.org/obo/UBERON_0003660		
UBERON:0001004	biolink:AnatomicalEntity	respiratory system	Functional system which consists of structures involved in respiration.	MAT:0000030|XAO:0000117|MA:0000327|EHDAA2:0001604|EFO:0000804|NCIT:C12779|MIAA:0000030|FMA:7158|EHDAA:2203|MESH:D012137|SCTID:278197002|EV:0100036|CALOHA:TS-1319|ZFA:0000272|BTO:0000203|Wikipedia:Respiratory_system|EMAPA:16727|AAO:0000541|GAID:78|OpenCyc:Mx4rvVjzFJwpEbGdrcN5Y29ycA|TAO:0000272|VHOG:0000202|UMLS:C0035237	hp.json	Atmungssystem|systema respiratorium|apparatus respiratorius|apparatus respiratorius|systema respiratorium|respiratory system	http://purl.obolibrary.org/obo/UBERON_0001004		uberon_slim|vertebrate_core|functional_classification|pheno_slim|efo_slim|human_reference_atlas
UBERON:0003667	biolink:AnatomicalEntity	lower jaw molar	A molar tooth that is part of a lower jaw [Automatically generated definition].	EMAPA:17921|MA:0001602|FMA:290267|EHDAA2:0001025|UMLS:C1708756|EHDAA:8017|NCIT:C49584	hp.json	lower molar|lower molar tooth|molar tooth of lower jaw|lower jaw molar tooth	http://purl.obolibrary.org/obo/UBERON_0003667		
UBERON:0001003	biolink:AnatomicalEntity	skin epidermis	The outer epithelial layer of the skin that is superficial to the dermis.	GAID:932|MIAA:0000154|XAO:0000028|Wikipedia:Epidermis_(skin)|MESH:D004817|ZFA:0000105|VHOG:0000077|TAO:0000105|EFO:0000954|CALOHA:TS-0283|BTO:0000404|UMLS:C0014520|FMA:70596|MA:0000153|MAT:0000154|EMAPA:17528|AAO:0000143|EV:0100153|NCIT:C12708|SCTID:361694003	hp.json	skin|vertebrate epidermis|epidermis	http://purl.obolibrary.org/obo/UBERON_0001003		uberon_slim|vertebrate_core|pheno_slim|efo_slim|human_reference_atlas
UBERON:0003665	biolink:AnatomicalEntity	post-anal tail muscle	A muscle organ that attaches to a tail vertebra [Automatically generated definition].	BTO:0001905|MA:0000699|AAO:0000081|EMAPA:37759	hp.json	tail muscle|tail muscle organ|post-vent region muscle organ|muscle organ of post-vent region|muscle organ of tail|caudal muscle	http://purl.obolibrary.org/obo/UBERON_0003665		
UBERON:0003666	biolink:AnatomicalEntity	upper jaw molar	A molar tooth that is part of a upper jaw [Automatically generated definition].	MA:0001603|EMAPA:17942|EHDAA:8053|EHDAA2:0002125|UMLS:C1710580|FMA:55720|NCIT:C49795	hp.json	maxillary secondary molar tooth|upper secondary molar tooth|upper molar|upper molar tooth|upper permanent molar tooth|molar tooth of upper jaw|upper jaw molar tooth	http://purl.obolibrary.org/obo/UBERON_0003666		
UBERON:0001005	biolink:AnatomicalEntity	respiratory airway	An airway through which respiratory air passes in organisms.	Wikipedia:Trachea|SCTID:361380005|FMA:265130	hp.json	airway|airways|airway|airways	http://purl.obolibrary.org/obo/UBERON_0001005		uberon_slim|grouping_class
UBERON:0001000	biolink:AnatomicalEntity	vas deferens	A secretory duct that transports sperm from the testis. In mammals this is a continuation of the epididymis and ends in the prostatic urethra where it terminates to form ejaculatory duct.	galen:VasDeferens|MA:0000413|NCIT:C12813|MESH:D014649|EV:0100105|BTO:0001427|FMA:19234|MIAA:0000129|EMAPA:18681|EFO:0000981|OpenCyc:Mx4rvjv7bpwpEbGdrcN5Y29ycA|UMLS:C0042360|CALOHA:TS-1105|GAID:404|VHOG:0001135	hp.json	vas deferen|sperm duct|deferent duct|ductus deferens|vasa deferentia	http://purl.obolibrary.org/obo/UBERON_0001000		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0003663	biolink:AnatomicalEntity	hindlimb muscle	Any muscle organ that is part of a hindlimb [Automatically generated definition].	FMA:37368|AAO:0000222|EFO:0001928	hp.json	muscle organ of inferior member|muscle organ of hind limb|lower limb skeletal muscle|lower extremity muscle organ|free lower limb muscle|muscle of free lower limb|muscle organ of lower extremity|hindlimb muscle organ|hind limb muscle organ|inferior member muscle organ|muscle organ of hindlimb|muscle of posterior limb	http://purl.obolibrary.org/obo/UBERON_0003663		efo_slim
UBERON:0003664	biolink:AnatomicalEntity	manual digit muscle	Any muscle organ that is part of a finger [Automatically generated definition].	EMAPA:37331|MA:0000624	hp.json	hand digit muscle|muscle organ of digit of terminal segment of free upper limb|digitus manus muscle organ|muscle organ of terminal segment of free upper limb digit|fore limb digit muscle|digit of hand muscle organ|digit of terminal segment of free upper limb muscle organ|muscle organ of digit of hand|finger muscle organ|terminal segment of free upper limb digit muscle organ|muscle organ of digitus manus|muscle organ of hand digit|hand digit muscle organ|hand digit muscle|muscle organ of finger	http://purl.obolibrary.org/obo/UBERON_0003664		
UBERON:0003661	biolink:AnatomicalEntity	limb muscle	Any muscle organ that is part of a limb [Automatically generated definition].	MA:0000692|EMAPA:32700	hp.json	limb muscle organ|muscle organ of limb|limb skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0003661		pheno_slim
UBERON:0003662	biolink:AnatomicalEntity	forelimb muscle	Any muscle organ that is part of a forelimb.	AAO:0000204|BTO:0000479|FMA:37348|EMAPA:36049	hp.json	arm muscle system|musculature of the arm|muscle of upper limb|musculature of arm|wing muscle|upper limb skeletal muscle|fore limb muscle organ|free upper limb muscle|muscle of free upper limb|wing muscle|forelimb muscle organ	http://purl.obolibrary.org/obo/UBERON_0003662		
MPATH:718	biolink:NamedThing	pre-sacral teratoma	Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine.		hp.json		http://purl.obolibrary.org/obo/MPATH_718		
HP:0500196	biolink:PhenotypicFeature	Abnormal CSF glutamine concentration	Any deviation from the normal concentration of glutamine amino acids in the cerebrospinal fluid.		hp.json	Abnormal glutamine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500196		
HP:0500197	biolink:PhenotypicFeature	Increased CSF glutamine concentration	Abnormally increased levels of glutamine in cerebrospinal fluid.		hp.json	High glutamine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500197		
HP:0500194	biolink:PhenotypicFeature	Decreased CSF isoleucine concentration	Abnormally decreased levels of isoleucine in cerebrospinal fluid.		hp.json	Low levels of isoleucine in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500194		
HP:0500195	biolink:PhenotypicFeature	Abnormal CSF glutamine family amino acid concentration	Any deviation from the normal concentration of glutamine-family amino acids in the cerebrospinal fluid.		hp.json	Abnormal glutamine family amino acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500195		
GO:1901888	biolink:BiologicalProcess	regulation of cell junction assembly	Any process that modulates the frequency, rate or extent of cell junction assembly.		hp.json		http://purl.obolibrary.org/obo/GO_1901888		
HP:0500198	biolink:PhenotypicFeature	Decreased CSF glutamine concentration	Abnormally decreased levels of glutamine in cerebrospinal fluid.		hp.json	Low glutamine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500198		
HP:0500199	biolink:PhenotypicFeature	Abnormal CSF glutamate concentration	Any deviation from the normal concentration of glutamic acid in the cerebrospinal fluid.		hp.json	Abnormal glutamic acid levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500199		
GO:1901889	biolink:BiologicalProcess	negative regulation of cell junction assembly	Any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly.		hp.json	down regulation of cell junction assembly|inhibition of cell junction assembly|down-regulation of cell junction assembly|downregulation of cell junction assembly	http://purl.obolibrary.org/obo/GO_1901889		
GO:1901880	biolink:BiologicalProcess	negative regulation of protein depolymerization	Any process that stops, prevents or reduces the frequency, rate or extent of protein depolymerization.		hp.json	down-regulation of protein polymer breakdown|negative regulation of protein polymer breakdown|inhibition of protein polymer catabolic process|inhibition of protein depolymerization|downregulation of protein polymer catabolism|down-regulation of protein depolymerization|downregulation of protein polymer degradation|down regulation of protein polymer breakdown|negative regulation of protein polymer catabolic process|down-regulation of protein polymer catabolic process|down regulation of protein polymer catabolism|inhibition of protein polymer degradation|downregulation of protein polymer breakdown|down regulation of protein polymer catabolic process|down-regulation of protein polymer catabolism|negative regulation of protein polymer catabolism|down-regulation of protein polymer degradation|negative regulation of protein polymer degradation|downregulation of protein polymer catabolic process|downregulation of protein depolymerization|inhibition of protein polymer catabolism|inhibition of protein polymer breakdown|down regulation of protein polymer degradation|down regulation of protein depolymerization	http://purl.obolibrary.org/obo/GO_1901880		
GO:1901881	biolink:BiologicalProcess	positive regulation of protein depolymerization	Any process that activates or increases the frequency, rate or extent of protein depolymerization.		hp.json	upregulation of protein polymer breakdown|positive regulation of protein polymer catabolic process|up-regulation of protein polymer catabolism|activation of protein polymer breakdown|upregulation of protein depolymerization|up-regulation of protein polymer degradation|upregulation of protein polymer catabolic process|up regulation of protein polymer degradation|activation of protein polymer catabolic process|positive regulation of protein polymer degradation|activation of protein polymer catabolism|up-regulation of protein polymer breakdown|up regulation of protein depolymerization|upregulation of protein polymer catabolism|up regulation of protein polymer breakdown|up-regulation of protein polymer catabolic process|upregulation of protein polymer degradation|up-regulation of protein depolymerization|activation of protein depolymerization|activation of protein polymer degradation|positive regulation of protein polymer catabolism|positive regulation of protein polymer breakdown|up regulation of protein polymer catabolic process|up regulation of protein polymer catabolism	http://purl.obolibrary.org/obo/GO_1901881		
UBERON:0001073	biolink:AnatomicalEntity	ileocecal junction	A point along the course of the gastrointestinal tract where the small intestine (ileum) ends as it opens into the cecal portion of the large intestine; occurs usually within the iliac fossa, demarcated internally as the ileocecal orifice.	MA:0000332|EMAPA:37601|FMA:11338	hp.json	ileocaecal junction	http://purl.obolibrary.org/obo/UBERON_0001073		
UBERON:0001072	biolink:AnatomicalEntity	posterior vena cava	A vein that carries deoxygenated blood from the lower half of the body into the right atrium of the heart.	MESH:D014682|GAID:548|NCIT:C12815|EMAPA:18416|BTO:0002682|AAO:0011083|XAO:0000388|EHDAA2:0000611|SCTID:181369003|VHOG:0001194|UMLS:C0042458|Wikipedia:Inferior_vena_cava|galen:InferiorVenaCava|MA:0000480|FMA:10951	hp.json	postcava|vena cava inferior|posterior vena cava|inferior vena cava|caudal vena cava|vena cava inferior|posterior vena cava|inferior vena cava|inferior caval vein|inferior caval vein|vena cava inferior	http://purl.obolibrary.org/obo/UBERON_0001072		human_reference_atlas|uberon_slim|pheno_slim
GO:1901890	biolink:BiologicalProcess	positive regulation of cell junction assembly	Any process that activates or increases the frequency, rate or extent of cell junction assembly.		hp.json	upregulation of cell junction assembly|up regulation of cell junction assembly|up-regulation of cell junction assembly|activation of cell junction assembly	http://purl.obolibrary.org/obo/GO_1901890		
UBERON:0001075	biolink:AnatomicalEntity	bony vertebral centrum	Ossified form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified].	EMAPA:36588|ZFA:0000126|MA:0001457|OpenCyc:Mx4rvXU4VpwpEbGdrcN5Y29ycA|TAO:0000126|UMLS:C0223084|NCIT:C12852|FMA:11945|AAO:0000697	hp.json	centra|corpus vertebrae|holocentrum|corpus vertebrae (vertebrale)|autocentrum|body of vertebra|vertebral centrum|vertebral body|corpus vertebra|arcocentrum|vertebral centra	http://purl.obolibrary.org/obo/UBERON_0001075		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001074	biolink:AnatomicalEntity	pericardial cavity	A potential space between the visceral and parietal layers of the pericardium.	TAO:0002220|VHOG:0000556|NCIT:C38662|SCTID:362027001|ZFA:0001655|Wikipedia:Pericardial_cavity|FMA:11350|BSA:0000091|galen:PericardialSpace|EMAPA:16132|EHDAA2:0001434|EMAPA:16131|MA:0000053|UMLS:C0225972	hp.json	cavitas pericardiaca|pericardial space|pericardial space|cavity of pericardial sac|cavitas pericardiaca	http://purl.obolibrary.org/obo/UBERON_0001074		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001071	biolink:AnatomicalEntity	superficial cervical artery	It ascends beneath the anterior margin of the trapezius, distributing branches to it, and to the neighboring muscles and lymph glands in the neck, and anastomosing with the superficial branch of the descending branch of the occipital artery.	NCIT:C53005|SCTID:161746006|Wikipedia:Superficial_part_of_transverse_cervical_artery|EMAPA:37117|FMA:10665|UMLS:C0226271|MA:0002052	hp.json	superficial branch of transverse cervical artery|superficial branch of transverse cervical artery	http://purl.obolibrary.org/obo/UBERON_0001071		uberon_slim|human_reference_atlas
UBERON:0001070	biolink:AnatomicalEntity	external carotid artery	A terminal branch of the left or right common carotid artery which supplies oxygenated blood to to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges[MP].	BTO:0004696|VHOG:0000265|XAO:0000345|AAO:0010416|AAO:0010218|EMAPA:18611|UMLS:C0007275|OpenCyc:Mx4rwVJkPZwpEbGdrcN5Y29ycA|EFO:0001953|NCIT:C32551|FMA:10635|MA:0001929|GAID:480|SCTID:362044002|EHDAA2:0000461|MESH:D002342|Wikipedia:External_carotid_artery	hp.json	arteria carotis externa|external carotid|arteria carotis externa	http://purl.obolibrary.org/obo/UBERON_0001070		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas|efo_slim
UBERON:0001077	biolink:AnatomicalEntity	transverse process of vertebra	The transverse or costal processes of a vertebra, two in number, project one at either side from the point where the lamina joins the pedicle, between the superior and inferior articular processes. They serve for the attachment of muscles and ligaments. [WP,unvetted].	MA:0001456|FMA:11949|XAO:0003102|AAO:0000698	hp.json	diapophyses|processus transversus|diapophysis|vertebra transverse process|transverse process|processus transversus vertebrae	http://purl.obolibrary.org/obo/UBERON_0001077		uberon_slim|pheno_slim
UBERON:0001076	biolink:AnatomicalEntity	neural spine	An extension of a neural arches dorsal to the neural canal[TAO,modified].	NCIT:C116112|EMAPA:25107|AAO:0000705|ZFA:0001336|TAO:0001336|MA:0001455|FMA:11948	hp.json	processus spinosus|spinous process of vertebra|processus spinosus vertebrae|spinous process|neural spine|neural spines|vertebra spinous process|spine of verterba	http://purl.obolibrary.org/obo/UBERON_0001076		uberon_slim|vertebrate_core|pheno_slim
UBERON:0001079	biolink:AnatomicalEntity	prezygapophysis	Paired processes at the cephalic end of the neural arch. The articular facets of the prezygapophyses face dorsomedially and articulate with the lateroventrally facing facets of the postzygapophyses of the preceding vertebra.	FMA:11953|ZFA:0001325|AAO:0000703|TAO:0001325|EMAPA:37802|MA:0001452	hp.json	vertebra cranial articular process|superior articular process of vertebra|prezygapophysis|processus articularis superior|neural prezygapophyses|cranial articular process of vertebra|neural prezygopophyses|neural prezygapophysis|zygapophysis superior|processus articularis superior vertebrae	http://purl.obolibrary.org/obo/UBERON_0001079		vertebrate_core
UBERON:0001078	biolink:AnatomicalEntity	pedicle of vertebra	The two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae.	FMA:11950|OpenCyc:Mx4rvYdjdJwpEbGdrcN5Y29ycA|MA:0001458|UMLS:C0223080|NCIT:C96274	hp.json	radix arcus vertebrae|pedicle|pediculus arcus vertebrae|pedicle of vertebral arch|pediculus arcus vertebrae|vertebral pedicle|vertebra pedicle	http://purl.obolibrary.org/obo/UBERON_0001078		pheno_slim|uberon_slim
HP:0500185	biolink:PhenotypicFeature	Abnormal CSF branched chain amino acid concentration	Any deviation from the normal concentration of branched-chain amino acids in the cerebrospinal fluid.		hp.json	Abnormal branched-chain amino acid levels in cerbrospinal fluid	http://purl.obolibrary.org/obo/HP_0500185		
HP:0500186	biolink:PhenotypicFeature	Abnormal CSF valine concentration	Any deviation from the normal concentration of valine in the cerebrospinal fluid.		hp.json	Abnormal valine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500186		
HP:0500183	biolink:PhenotypicFeature	Abnormal CSF carboxylic acid concentration	Any deviation from the normal concentration of a carboxylic acid in the cerebrospinal fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0500183		
HP:0500184	biolink:PhenotypicFeature	Abnormal CSF amino acid concentration	Any deviation from the normal concentration of amino acids in the cerebrospinal fluid.		hp.json	Abnormal CSF amino acid level|Abnormal amino acid levels in cerebrospinal fluid|Abnormal cerebrospinal fluid amino acid level	http://purl.obolibrary.org/obo/HP_0500184		
HP:0500189	biolink:PhenotypicFeature	Abnormal CSF leucine concentration	Any deviation from the normal concentration of leucine in the cerebrospinal fluid.		hp.json	Abnormal leucine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500189		
HP:0500187	biolink:PhenotypicFeature	Increased CSF valine concentration	Any increased amount from normal of valine in the cerebrospinal fluid.		hp.json	High valine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500187		
HP:0500188	biolink:PhenotypicFeature	Decreased CSF valine concentration	Any decreased amount from normal of valine in the cerebrospinal fluid.		hp.json	Low valine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500188		
UBERON:0001062	biolink:AnatomicalEntity	anatomical entity	Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species.	TAO:0100000|WBbt:0000100|TGMA:0001822|UMLS:C1515976|BILA:0000000|CARO:0000000|AEO:0000000|NCIT:C12219|EHDAA2:0002229|FMA:62955|HAO:0000000|XAO:0000000|FBbt:10000000|AAO:0010841|MA:0000001|ZFA:0100000|BIRNLEX:6	hp.json		http://purl.obolibrary.org/obo/UBERON_0001062		upper_level
UBERON:0001064	biolink:AnatomicalEntity	ventral pancreatic duct	A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla.	UMLS:C0030288|EHDAA2:0001396|MESH:D010183|NCIT:C12272|VHOG:0000256|GAID:337|EHDAA:6905|BTO:0002362|MA:0000126|EMAPA:17510|FMA:16003|RETIRED_EHDAA2:0002177	hp.json	pancreatic duct|main pancreatic duct|chief pancreatic duct|canal of Wirsung|ductus pancreatis ventralis|duct of Wirsung|hepaticopancreatic duct	http://purl.obolibrary.org/obo/UBERON_0001064		human_reference_atlas|uberon_slim
GO:0070345	biolink:BiologicalProcess	negative regulation of fat cell proliferation	Any process that stops or decreases the rate or extent of fat cell proliferation.		hp.json	downregulation of fat cell proliferation|negative regulation of adipocyte proliferation|down regulation of fat cell proliferation|inhibition of fat cell proliferation|down-regulation of fat cell proliferation|negative regulation of adipose cell proliferation	http://purl.obolibrary.org/obo/GO_0070345		
GO:0070346	biolink:BiologicalProcess	positive regulation of fat cell proliferation	Any process that activates or increases the rate or extent of fat cell proliferation.		hp.json	positive regulation of adipocyte proliferation|up-regulation of fat cell proliferation|activation of fat cell proliferation|upregulation of fat cell proliferation|positive regulation of adipose cell proliferation|up regulation of fat cell proliferation|stimulation of fat cell proliferation	http://purl.obolibrary.org/obo/GO_0070346		
HP:0500192	biolink:PhenotypicFeature	Abnormal CSF isoleucine concentration	Any deviation from the normal concentration of isoleucine in the cerebrospinal fluid.		hp.json	Abnormal isoleucine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500192		
UBERON:0001066	biolink:AnatomicalEntity	intervertebral disk	A pad of fibrocartilage between the articular surfaces of two successive vertebral centra which has nucleus pulposus at its core.	UMLS:C0021815|MESH:D007403|FMA:10446|NCIT:C49571|GAID:105|EFO:0001370|EMAPA:32739|OpenCyc:Mx4rv11AcpwpEbGdrcN5Y29ycA|MA:0000110|BTO:0003625	hp.json	spinal disk|spinal disc|intervertebral disc|intervertebral fibrocartilage|discus intervertebralis	http://purl.obolibrary.org/obo/UBERON_0001066		pheno_slim|efo_slim|uberon_slim
GO:0070344	biolink:BiologicalProcess	regulation of fat cell proliferation	Any process that modulates the frequency, rate or extent of fat cell proliferation.		hp.json	regulation of adipose cell proliferation|regulation of adipocyte proliferation	http://purl.obolibrary.org/obo/GO_0070344		
HP:0500193	biolink:PhenotypicFeature	Increased CSF isoleucine concentration	Abnormally increased levels of isoleucine in cerebrospinal fluid.		hp.json	High levels of isoleucine in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500193		
UBERON:0001068	biolink:AnatomicalEntity	skin of back	A zone of skin that is part of a back [Automatically generated definition].	EMAPA:36392|FMA:22985|SCTID:181492002|FMA:10462|MA:0000498	hp.json	back skin|skin, dorsal region|zone of skin of back|skin, dorsal region|back zone of skin	http://purl.obolibrary.org/obo/UBERON_0001068		pheno_slim
GO:0070341	biolink:BiologicalProcess	fat cell proliferation	The multiplication or reproduction of fat cells by cell division, resulting in the expansion of their population. A fat cell is an animal connective tissue cell specialized for the synthesis and storage of fat.		hp.json	adipocyte proliferation|adipose cell proliferation	http://purl.obolibrary.org/obo/GO_0070341		
HP:0500190	biolink:PhenotypicFeature	Decreased CSF leucine concentration	Abnormally decreased levels of leucine in the cerebrospinal fluid.		hp.json	Low leucine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500190		
UBERON:0001067	biolink:AnatomicalEntity	vertebral arch joint	A synovial joint between the prezygapophysis of one vertebra and the postzygapophysis of the vertebra directly above it. There are two facet joints in each spinal motion segment[WP].	FMA:10447|MESH:D021801|MA:0001513|NCIT:C32577|OpenCyc:Mx4rvorHEpwpEbGdrcN5Y29ycA|UMLS:C0224521|GAID:275	hp.json	joint of vertebral arch|articulationes zygapophysiales|zygapophysial joint|facet joint|joint of vertebral articular process|zygapophyseal joint|spinal facet joint	http://purl.obolibrary.org/obo/UBERON_0001067		pheno_slim|uberon_slim
HP:0500191	biolink:PhenotypicFeature	Increased CSF leucine concentration	Abnormally increased levels of leucine in cerebrospinal fluid.		hp.json	High leucine levels in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0500191		
HP:0500173	biolink:PhenotypicFeature	Reflex asystolic syncope	A loss of consciousness followed by stiffening and brief clonic movements affecting some or all limbs, often misinterpreted as an epileptic seizure.		hp.json	Reflex anoxic seizures|Reflex anoxic seizure	http://purl.obolibrary.org/obo/HP_0500173		
PR:P35918	biolink:Protein	vascular endothelial growth factor receptor 2 (mouse)	A vascular endothelial growth factor receptor 2 that is encoded in the genome of mouse.	UniProtKB:P35918	hp.json	FLK-1 (mouse)|VEGFR-2 (mouse)|mKDR|kinase NYK (mouse)|Flk1|Flk-1|Kdr|fetal liver kinase 1 (mouse)|protein-tyrosine kinase receptor flk-1 (mouse)|CD309 (mouse)	http://purl.obolibrary.org/obo/PR_P35918		
UBERON:0001051	biolink:AnatomicalEntity	hypopharynx	Bottom part of the pharynx that connects to the esophagus.	EV:0100068|EFO:0001388|EHDAA2:0004574|BTO:0001740|VHOG:0000445|GAID:338|MESH:D007013|UMLS:C0020629|OpenCyc:Mx4rvq5O0JwpEbGdrcN5Y29ycA|FMA:54880|MA:0001796|NCIT:C12246|CALOHA:TS-2020	hp.json	pars laryngea pharyngis|laryngopharynx|pars laryngea pharyngis|laryngeal pharynx	http://purl.obolibrary.org/obo/UBERON_0001051		pheno_slim|efo_slim|uberon_slim
UBERON:0001052	biolink:AnatomicalEntity	rectum	The terminal portion of the intestinal tube, terminating with the anus.	OpenCyc:Mx4rvVjaU5wpEbGdrcN5Y29ycA|BTO:0001158|CALOHA:TS-1180|SCTID:181261002|EHDAA2:0001592|XAO:0000238|FMA:14544|VHOG:0001751|MAT:0000050|MA:0000336|EFO:0000848|NCIT:C12390|EHDAA:5836|Wikipedia:Rectum|EMAPA:17896|EV:0100081|GAID:311|MESH:D012007|MIAA:0000050|UMLS:C0034896|galen:Rectum|AAO:0010401	hp.json	terminal portion of large intestine|intestinum rectum|rectal sac|terminal portion of intestine	http://purl.obolibrary.org/obo/UBERON_0001052		pheno_slim|efo_slim|human_reference_atlas|uberon_slim
HP:0500181	biolink:PhenotypicFeature	Hypertaurinemia	An increased amount of taurine in the blood.		hp.json	Elevated serum taurine levels|Increased circulating taurine levels in the blood	http://purl.obolibrary.org/obo/HP_0500181		
HP:0500182	biolink:PhenotypicFeature	Hypotaurinemia	A decreased amount of taurine in the blood.		hp.json	Reduced taurine levels in the blood|Decreased circulating taurine levels|Lower blood levels of taurine	http://purl.obolibrary.org/obo/HP_0500182		
HP:0500180	biolink:PhenotypicFeature	Abnormal circulating amino sulfonic acid concentration			hp.json		http://purl.obolibrary.org/obo/HP_0500180		
HP:0500163	biolink:PhenotypicFeature	Hypoornithinemia	An abnormal decrease in ornithine in the blood.		hp.json	Decreased blood ornithine concentrations|Low blood ornithine levels	http://purl.obolibrary.org/obo/HP_0500163		
HP:0500164	biolink:PhenotypicFeature	Abnormal blood carbon dioxide level	An abnormality of carbon dioxide (CO2) in the arterial blood.		hp.json	Abnormal blood carbon dioxide level|Abnormal CO2 levels in blood	http://purl.obolibrary.org/obo/HP_0500164		
HP:0500161	biolink:PhenotypicFeature	Increased level of carnosine in blood	An increased amount of carnosine in the blood.		hp.json	Increased blood carnosine concenrtation|High blood carnosine levels	http://purl.obolibrary.org/obo/HP_0500161		
HP:0500162	biolink:PhenotypicFeature	Decreased level of carnosine in blood	A decreased amount of carnosine in bood.		hp.json	Decreased blood carnosine concentration|Low blood carnosine levels	http://purl.obolibrary.org/obo/HP_0500162		
HP:0500167	biolink:PhenotypicFeature	Hypergastrinemia	An elevated amount of gastrin in the blood.		hp.json	Elevated gastrin in the blood|Increased blood gastrin	http://purl.obolibrary.org/obo/HP_0500167		
HP:0500165	biolink:PhenotypicFeature	Abnormal blood oxygen level	An abnormality of the partial pressure of oxygen in the arterial blood.		hp.json	Abnormal O2 blood concentration|Abnormal blood oxygen levels|Abnormal blood O2 level	http://purl.obolibrary.org/obo/HP_0500165		
HP:0500166	biolink:PhenotypicFeature	Abnormal circulating gastrin concentration	An abnormal concentration of gastrin in the blood.		hp.json	Abnormal circulating gastrin level	http://purl.obolibrary.org/obo/HP_0500166		
UBERON:0001040	biolink:AnatomicalEntity	yolk sac	A sac-like expansion of the ventral wall of the intestine, narrowed into a yolk stalk near the body[Hyman's]. Membranous sac attached to an embryo, providing early nourishment in the form of yolk in bony fishes, sharks, reptiles, birds, and primitive mammals. It functions as the developmental circulatory system of the human embryo, before internal circulation begins. In the mouse, the yolk sac is the first site of blood formation, generating primitive macrophages and erythrocytes[WP].	FMA:87180|MESH:D015017|EHDAA2:0002212|GAID:1301|EMAPA:16085|EHDAA:164|VHOG:0000830|EFO:0003078|UMLS:C0043425|BTO:0001471|Wikipedia:Yolk_sac|SCTID:362845002|CALOHA:TS-1130|NCIT:C14128	hp.json	saccus vitellinus|vesicula umbilicalis|saccus vitellinus|vesicula umbilicalis	http://purl.obolibrary.org/obo/UBERON_0001040		pheno_slim|efo_slim|uberon_slim
UBERON:0001042	biolink:AnatomicalEntity	chordate pharynx	A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED].	TAO:0000056|EMAPA:16706|BTO:0001049|Wikipedia:Pharynx|UMLS:C0031354|EV:0100065|FMA:46688|SCTID:181211006|EHDAA:2947|MESH:A03.867|CALOHA:TS-0785|OpenCyc:Mx4rvViv7ZwpEbGdrcN5Y29ycA|MESH:D010614|XAO:0003227|VHOG:0000462|AAO:0000967|EFO:0000836|EHDAA2:0001458|MA:0000432|NCIT:C12425|ZFA:0000056|GAID:155|galen:Pharynx	hp.json	pharynx	http://purl.obolibrary.org/obo/UBERON_0001042		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0001041	biolink:AnatomicalEntity	foregut	Anterior subdivision of a digestive tract.	EHDAA:520|FMA:45616|Wikipedia:Foregut|EMAPA:16548|AAO:0011042|MA:0001526|VHOG:0000285|NCIT:C34180|BTO:0000507|TGMA:0001014|BILA:0000085|SCTID:361409009|UMLS:C0231051|EHDAA2:0000557|XAO:0000232|FBbt:00005379	hp.json	proenteron|praeenteron|praeenteron|proenteron	http://purl.obolibrary.org/obo/UBERON_0001041		pheno_slim|developmental_classification|uberon_slim
UBERON:0001048	biolink:AnatomicalEntity	primordium	Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)].	AEO:0000171|Wikipedia:Primordium|FMA:86589|XAO:0003043|BTO:0001886|FBbt:00005495|EFO:0001652|NCIT:C34275|MAT:0000482|UMLS:C0678727|EHDAA2:0003171	hp.json	future organ|bud|placode|primordia|rudiment	http://purl.obolibrary.org/obo/UBERON_0001048		pheno_slim|efo_slim|uberon_slim
UBERON:0001049	biolink:AnatomicalEntity	neural tube	In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted].	MESH:D054259|ZFA:0001135|NCIT:C34226|UMLS:C0231024|EMAPA:16164|TAO:0001135|VHOG:0000307|DHBA:10154|MAT:0000069|CALOHA:TS-2371|EHDAA:908|EHDAA2:0001254|FMA:293882|MIAA:0000069|BTO:0001057|EMAPA:16757|AAO:0010617|EHDAA:2869|Wikipedia:Neural_tube|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1365|XAO:0003204|SCTID:362852000	hp.json	tubus neuralis|presumptive central nervous system|tubus neuralis|neural primordium	http://purl.obolibrary.org/obo/UBERON_0001049		vertebrate_core|pheno_slim|uberon_slim
UBERON:0001044	biolink:AnatomicalEntity	saliva-secreting gland	Saliva-secreting exocrine glands of the oral cavity[GO].	EHDAA2:0001775|EHDAA:7987|EV:0100059|FMA:9597|OpenCyc:Mx4rvVjl5ZwpEbGdrcN5Y29ycA|GAID:937|MAT:0000079|BTO:0001203|galen:SalivaryGland|FBbt:00005382|MIAA:0000079|VHOG:0000376|UMLS:C0036098|EFO:0000859|CALOHA:TS-0892|MA:0000346|NCIT:C12426|EMAPA:17751|MESH:D012469	hp.json	salivary gland|glandulae salivariae	http://purl.obolibrary.org/obo/UBERON_0001044		functional_classification|organ_slim|pheno_slim|efo_slim|uberon_slim
HP:0500170	biolink:PhenotypicFeature	Abnormal concentration of acylcarnitine in the urine	An abnormal amount of acylcarnitine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0500170		
UBERON:0001043	biolink:AnatomicalEntity	esophagus	Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993).	Wikipedia:Esophagus|MA:0000352|NCIT:C12389|MAT:0000048|EV:0100069|FMA:7131|AAO:0000145|MIAA:0000048|CALOHA:TS-0700|EHDAA2:0001285|GAID:291|OpenCyc:Mx4rvVj9Q5wpEbGdrcN5Y29ycA|ANISEED:1235301|EHDAA:2937|UMLS:C0014876|EMAPA:16833|XAO:0000127|ZFA:0000204|SCTID:181245004|BTO:0000959|VHOG:0000450|MESH:D004947|EFO:0000835|galen:Esophagus|TAO:0000204	hp.json	oesophagus|gullet	http://purl.obolibrary.org/obo/UBERON_0001043		organ_slim|pheno_slim|efo_slim|uberon_slim|vertebrate_core|major_organ
UBERON:0001046	biolink:AnatomicalEntity	hindgut	The caudalmost subdivision of a digestive tract.	Wikipedia:Hindgut|FMA:45618|UMLS:C0231053|TGMA:0001020|VHOG:0000459|BTO:0000510|NCIT:C34188|EMAPA:16715|FBbt:00005384|MA:0001527|AAO:0011052|XAO:0000104|BILA:0000087|EHDAA2:0000779|EHDAA:975|SCTID:362856002	hp.json	metenteron|metenteron	http://purl.obolibrary.org/obo/UBERON_0001046		pheno_slim|developmental_classification|uberon_slim
UBERON:0001045	biolink:AnatomicalEntity	midgut	Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO].	MA:0001564|FMA:45617|EHDAA:983|VHOG:0000290|BTO:0000863|NCIT:C34210|EFO:0001950|FBbt:00005383|SCTID:361410004|UMLS:C0231052|EHDAA2:0001185|Wikipedia:Midgut|BILA:0000086|XAO:0000103|TGMA:0001036|EMAPA:16255	hp.json	mesenteron|mesenteron	http://purl.obolibrary.org/obo/UBERON_0001045		pheno_slim|developmental_classification|efo_slim|uberon_slim
HP:0030290	biolink:PhenotypicFeature	Unossified sacrum	Lack of ossification of the sacrum.	UMLS:C2675562	hp.json	Absence of sacrum ossification	http://purl.obolibrary.org/obo/HP_0030290		
UBERON:0005908	biolink:AnatomicalEntity	conjunctival sac	A serous sac which is the aggregate of the conjunctiva plus the conjunctival space.	FMA:20291|EMAPA:18233	hp.json	subbrillar sac|conjunctiva serous sac	http://purl.obolibrary.org/obo/UBERON_0005908		
HP:0030291	biolink:PhenotypicFeature	Lower-limb metaphyseal irregularity	Irregularity of the normally smooth surface of one or more metaphyses of a bone of the leg.	UMLS:C4022534	hp.json		http://purl.obolibrary.org/obo/HP_0030291		
UBERON:0005906	biolink:AnatomicalEntity	serous sac	Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA].	EMAPA:16060|MA:0000005|FMA:9689|SCTID:362890006	hp.json		http://purl.obolibrary.org/obo/UBERON_0005906		
HP:0030292	biolink:PhenotypicFeature	Tibial metaphyseal irregularity	Irregularity of the normally smooth surface of a metaphysis of a tibia.	UMLS:C4022533	hp.json		http://purl.obolibrary.org/obo/HP_0030292		
UBERON:0005904	biolink:AnatomicalEntity	duct of male reproductive system	Any of the ducts that are part of a male reproductive system.		hp.json		http://purl.obolibrary.org/obo/UBERON_0005904		grouping_class
UBERON:0005903	biolink:AnatomicalEntity	duct of seminal vesicle	Each seminal vesicle consists of a single tube, coiled upon itself, and giving off several irregular cecal diverticula; the separate coils, as well as the diverticula, are connected together by fibrous tissue. When uncoiled, the tube is about the diameter of a quill, and varies in length from 10 to 15 cm.; it ends posteriorly in a cul-de-sac; its anterior extremity becomes constricted into a narrow straight duct called the excretory duct of seminal gland (or duct of the seminal vesicle), which joins with the corresponding ductus deferens to form the ejaculatory duct[WP].	EMAPA:29282|FMA:19473	hp.json	ductus excretorius (vesicula seminalis)|excretory duct of seminal gland|ductus excretorius glandulae vesiculosae|ductus excretorius glandulae vesiculosae|seminal vesicle duct	http://purl.obolibrary.org/obo/UBERON_0005903		
GO:0021543	biolink:BiologicalProcess	pallium development	The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon.		hp.json		http://purl.obolibrary.org/obo/GO_0021543		
UBERON:0005902	biolink:AnatomicalEntity	occipital region	Anatomical cluster that is located in the posterior region of the cranium and forms the margin of the foramen magnum and occipital condyles.	AAO:0010199|XAO:0003173|BTO:0004675|ZFA:0001414|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2431|TAO:0001414|FMA:49187|SCTID:362618001	hp.json	occipital region of head|occipital part of head|back of head|basicranial region	http://purl.obolibrary.org/obo/UBERON_0005902		
HP:0030297	biolink:PhenotypicFeature	Metaphyseal chondromatosis of ulna		UMLS:C4022528	hp.json		http://purl.obolibrary.org/obo/HP_0030297		
HP:0030298	biolink:PhenotypicFeature	Metaphyseal chondromatosis of humerus		UMLS:C4021860	hp.json		http://purl.obolibrary.org/obo/HP_0030298		
HP:0030299	biolink:PhenotypicFeature	Distal femoral metaphyseal abnormality	An anomaly of the metaphysis of the distal femur (close to the knee).	UMLS:C4022527	hp.json	Abnormality of wide portion of outermost thighbone	http://purl.obolibrary.org/obo/HP_0030299		
HP:0030293	biolink:PhenotypicFeature	Fibular metaphyseal irregularity	Irregularity of the normally smooth surface of a metaphysis of a fibula.	UMLS:C4022532	hp.json	Irregularity of wide portion of calf bone	http://purl.obolibrary.org/obo/HP_0030293		
HP:0030294	biolink:PhenotypicFeature	Metaphyseal chondromatosis of tibia		UMLS:C4022531	hp.json		http://purl.obolibrary.org/obo/HP_0030294		
HP:0030295	biolink:PhenotypicFeature	Metaphyseal chondromatosis of femur		UMLS:C4022530	hp.json		http://purl.obolibrary.org/obo/HP_0030295		
HP:0030296	biolink:PhenotypicFeature	Metaphyseal chondromatosis of radius		UMLS:C4022529	hp.json		http://purl.obolibrary.org/obo/HP_0030296		
CHEBI:58375	biolink:ChemicalSubstance	trans-4-hydroxy-L-proline zwitterion	An L-alpha-amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of trans-4-hydroxy-L-proline; major species at pH 7.3.		hp.json	(2S,4R)-4-hydroxypyrrolidinium-2-carboxylate|trans-4-hydroxy-L-proline|hydroxyproline zwitterion	http://purl.obolibrary.org/obo/CHEBI_58375		3_STAR
GO:0021545	biolink:BiologicalProcess	cranial nerve development	The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.		hp.json		http://purl.obolibrary.org/obo/GO_0021545		
UBERON:0005911	biolink:AnatomicalEntity	endo-epithelium	Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA].	FMA:69065	hp.json	endoepithelium|endoderm-derived epithelium	http://purl.obolibrary.org/obo/UBERON_0005911		
GO:0021546	biolink:BiologicalProcess	rhombomere development	The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.		hp.json		http://purl.obolibrary.org/obo/GO_0021546		
GO:0021547	biolink:BiologicalProcess	midbrain-hindbrain boundary initiation	The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.		hp.json	midbrain-hindbrain boundary formation|isthmus biosynthesis|isthmus formation|MHB formation|MHB biosynthesis|midbrain-hindbrain boundary biosynthesis	http://purl.obolibrary.org/obo/GO_0021547		
GO:0021548	biolink:BiologicalProcess	pons development	The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.		hp.json		http://purl.obolibrary.org/obo/GO_0021548		
GO:0021532	biolink:BiologicalProcess	neural tube patterning	The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.		hp.json		http://purl.obolibrary.org/obo/GO_0021532		
GO:0021533	biolink:BiologicalProcess	cell differentiation in hindbrain	The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0021533		
GO:0021534	biolink:BiologicalProcess	cell proliferation in hindbrain	The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain.		hp.json		http://purl.obolibrary.org/obo/GO_0021534		
GO:0021535	biolink:BiologicalProcess	cell migration in hindbrain	The orderly movement of a cell that will reside in the hindbrain.		hp.json		http://purl.obolibrary.org/obo/GO_0021535		
GO:0021536	biolink:BiologicalProcess	diencephalon development	The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.		hp.json		http://purl.obolibrary.org/obo/GO_0021536		
GO:0021537	biolink:BiologicalProcess	telencephalon development	The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.		hp.json	cerebrum development	http://purl.obolibrary.org/obo/GO_0021537		
GO:0021522	biolink:BiologicalProcess	spinal cord motor neuron differentiation	The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0021522		
GO:0008544	biolink:BiologicalProcess	epidermis development	The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.		hp.json	hypodermis development	http://purl.obolibrary.org/obo/GO_0008544		
UBERON:2001626	biolink:AnatomicalEntity	premaxillary tooth	Tooth that is attached to the premaxilla.		hp.json		http://purl.obolibrary.org/obo/UBERON_2001626		
GO:0033500	biolink:BiologicalProcess	carbohydrate homeostasis	A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0033500		
GO:0021510	biolink:BiologicalProcess	spinal cord development	The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.		hp.json		http://purl.obolibrary.org/obo/GO_0021510		
GO:0021514	biolink:BiologicalProcess	ventral spinal cord interneuron differentiation	The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0021514		
GO:0021515	biolink:BiologicalProcess	cell differentiation in spinal cord	The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0021515		
GO:0021517	biolink:BiologicalProcess	ventral spinal cord development	The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.		hp.json		http://purl.obolibrary.org/obo/GO_0021517		
GO:0008528	biolink:MolecularActivity	G protein-coupled peptide receptor activity	Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.		hp.json	peptide receptor activity, G-protein coupled|peptide receptor activity, G protein coupled|G-protein coupled peptide receptor activity|G protein coupled peptide receptor activity	http://purl.obolibrary.org/obo/GO_0008528		
GO:0008527	biolink:MolecularActivity	taste receptor activity	Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.		hp.json	gustatory receptor	http://purl.obolibrary.org/obo/GO_0008527		
UBERON:0005946	biolink:AnatomicalEntity	outflow tract of atrium	An outflow tract that is part of a cardiac atrium.	FMA:14141	hp.json	outflow part of atrium	http://purl.obolibrary.org/obo/UBERON_0005946		
HP:0030253	biolink:PhenotypicFeature	Defective T cell proliferation	A reduced ability of a T cell population to expand by cell division following T cell activation.	UMLS:C4022557	hp.json		http://purl.obolibrary.org/obo/HP_0030253		
HP:0030254	biolink:PhenotypicFeature	Nail bed hemorrhage	Small areas of bleeding (hemorrhage) under the fingernail or toenail.	UMLS:C0877087	hp.json	Nail bed haemorrhage	http://purl.obolibrary.org/obo/HP_0030254		
HP:0030255	biolink:PhenotypicFeature	Large intestinal polyposis	The presence of multiple polyps in the large intestine.	UMLS:C4022556	hp.json		http://purl.obolibrary.org/obo/HP_0030255		
HP:0030256	biolink:PhenotypicFeature	Small intestinal polyposis	The presence of multiple polyps in the small intestine.	UMLS:C4022555	hp.json		http://purl.obolibrary.org/obo/HP_0030256		
HP:0030250	biolink:PhenotypicFeature	Pulmonary granulomatosis	The presence of multiple granulomata (small nodular inflammatory lesions containing grouped mononuclear phagocytes) in the lung.	UMLS:C0856628	hp.json		http://purl.obolibrary.org/obo/HP_0030250		
HP:0030251	biolink:PhenotypicFeature	Absence of memory B cells	Complete lack of memory B cells, that is, of mature B cell type that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin.	UMLS:C4022559	hp.json		http://purl.obolibrary.org/obo/HP_0030251		
HP:0030252	biolink:PhenotypicFeature	Absent circulating B cells	Complete lack of mature B cells, that is, of B cells that have left the bone marrow.	UMLS:C4022558	hp.json	Absence of mature B cells	http://purl.obolibrary.org/obo/HP_0030252		
HP:0030257	biolink:PhenotypicFeature	Freckled genitalia	One or more brown punctate macules on the skin of the genitalia.	UMLS:C4021040	hp.json	Freckled genitalia|Genitalia, ephelides	http://purl.obolibrary.org/obo/HP_0030257		
HP:0030258	biolink:PhenotypicFeature	Hyperpigmented genitalia	Localized or generalized increased genital pigmentation.	UMLS:C4022554|UMLS:C4020713	hp.json	Increased genital pigmentation|Penile melanosis	http://purl.obolibrary.org/obo/HP_0030258		
HP:0030259	biolink:PhenotypicFeature	Hypopigmented genitalia	Localized or generalized decreased genital pigmentation.	UMLS:C4022553	hp.json	Decreased genital pigmentation	http://purl.obolibrary.org/obo/HP_0030259		
UBERON:0005956	biolink:AnatomicalEntity	outflow part of left ventricle	Anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta.	EMAPA:37925|SCTID:264070001|FMA:9473|Wikipedia:Aortic_vestibule	hp.json	heart left ventricle outflow tract|LVOT|left ventricular outflow|vestibulum aortae|aortic vestibule|outflow tract of left ventricle|aortic vestibule|Sibson vestibule|left ventricular outflow tract	http://purl.obolibrary.org/obo/UBERON_0005956		pheno_slim
GO:0021501	biolink:BiologicalProcess	prechordal plate formation	The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.		hp.json		http://purl.obolibrary.org/obo/GO_0021501		
UBERON:0005953	biolink:AnatomicalEntity	outflow part of right ventricle	Anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk.	UMLS:C1881209|SCTID:244379003|NCIT:C61368|EMAPA:37926|FMA:7216	hp.json	infundibulum of right ventricle|right ventricle pulmonary outflow tract|infundibulum|pulmonary conus|pulmonary cone|right ventricular outflow tract|arterial cone|RVOT|conus arteriosus (infundibulum)|pulmonary conus|outflow tract of right ventricle|conus arteriosus|infundibulum|infundibulum of right ventricle	http://purl.obolibrary.org/obo/UBERON_0005953		
HP:0030264	biolink:PhenotypicFeature	Webbed penis	Ventral skinfold extending from penis to scrotum.	SNOMEDCT_US:253852007|UMLS:C0431670	hp.json	Webbed penis	http://purl.obolibrary.org/obo/HP_0030264		
HP:0030265	biolink:PhenotypicFeature	Wide penis	Distance between left and right side of the flaccid penis at the attachment to the skin above the pubic symphysis more than 2 standard deviations above the mean for age.	UMLS:C4022551	hp.json	Wide penis	http://purl.obolibrary.org/obo/HP_0030265		
HP:0030266	biolink:PhenotypicFeature	obsolete Abnormality of the sacroiliac notch			hp.json		http://purl.obolibrary.org/obo/HP_0030266		
HP:0030267	biolink:PhenotypicFeature	Calcification of the interosseus membrane of the forearm	Deposition of calcium salts in the fibrous sheet that connects the radius and the ulna.	UMLS:C4022549	hp.json		http://purl.obolibrary.org/obo/HP_0030267		
HP:0030260	biolink:PhenotypicFeature	Microphallus	Length of penis more than 2 SD below the mean for age accompanied by hypospadias.	SNOMEDCT_US:276333003|UMLS:C0240701	hp.json		http://purl.obolibrary.org/obo/HP_0030260		
HP:0030261	biolink:PhenotypicFeature	Absent penis	Lack of recognizable penile structures.	SNOMEDCT_US:59981001|UMLS:C0555231|SNOMEDCT_US:204908001	hp.json	Penis aplasia|Aplasia of the penis|Absent penis|Aphallia	http://purl.obolibrary.org/obo/HP_0030261		
HP:0030262	biolink:PhenotypicFeature	Narrow penis	Penile width more than 2 standard deviations (SD) below the mean for age. Alternatively circumference of the flaccid penis more than 2 SD below the mean for age. Alternatively, apparently decreased penile width for age.	UMLS:C4022552	hp.json	Narrow penis	http://purl.obolibrary.org/obo/HP_0030262		
HP:0030263	biolink:PhenotypicFeature	Torsion of the penis	Rotated position of the glans, with or without the penile shaft, of 30 degrees or more.	UMLS:C1407019	hp.json		http://purl.obolibrary.org/obo/HP_0030263		
GO:0070507	biolink:BiologicalProcess	regulation of microtubule cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.		hp.json	regulation of microtubule cytoskeleton organisation|regulation of microtubule dynamics	http://purl.obolibrary.org/obo/GO_0070507		
HP:0030268	biolink:PhenotypicFeature	Hyperplastic callus formation	Increased growth of callus, the bony and cartilaginous material that forms a connecting bridge across a bone fracture during fracture healing.	UMLS:C4022548	hp.json		http://purl.obolibrary.org/obo/HP_0030268		
HP:0030269	biolink:PhenotypicFeature	Increased circulating insulin-like growth factor 1 concentration	An elevated level of insulin-like growth factor 1 (IGF1) in the blood circulation.	UMLS:C2676198	hp.json	Increased serum IGF1|Increased serum insulin-like growth factor 1|Elevated serum IGF1	http://purl.obolibrary.org/obo/HP_0030269		
UBERON:0005945	biolink:AnatomicalEntity	neurocranial trabecula		ZFA:0001321|TAO:0001321|EFO:0003677	hp.json	trabecular cartilage|neurocranial trabeculae|trabecula	http://purl.obolibrary.org/obo/UBERON_0005945		efo_slim
UBERON:0005944	biolink:AnatomicalEntity	axial skeleton plus cranial skeleton	Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified].	EMAPA:17214|UMLS:C0222645|AAO:0000963|SCTID:361725000|XAO:0004011|EMAPA:18043|MA:0000308|NCIT:C32172|VSAO:0000056|Wikipedia:Axial_skeleton	hp.json	skeleton axiale|skeleton axiale	http://purl.obolibrary.org/obo/UBERON_0005944		pheno_slim|uberon_slim
UBERON:0005928	biolink:AnatomicalEntity	external naris	A naris that provides one of the small external openings of the head that give passage to air for breathing.	EMAPA:17848|EHDAA2:0001275|VHOG:0000544|FMA:59645|UMLS:C0595944|OpenCyc:Mx4rvViCLpwpEbGdrcN5Y29ycA|EHDAA:9085|AAO:0010358|ZFA:0000550|MA:0001320|NCIT:C33178|XAO:0003033|AAO:0000983|TAO:0000550|AAO:0000024	hp.json	anterior nares|blowhole|naris|external nares|anterior naris|nostril	http://purl.obolibrary.org/obo/UBERON_0005928		vertebrate_core|pheno_slim
HP:0030270	biolink:PhenotypicFeature	Elevated red cell adenosine deaminase level	Increase in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.	UMLS:C4022547	hp.json		http://purl.obolibrary.org/obo/HP_0030270		
CHEBI:48999	biolink:ChemicalSubstance	4-hydroxyphenylacetate	A monocarboxylic acid anion that is obtained by removal of a proton from the carboxylic acid group of 4-hydroxyphenylacetic acid.	Reaxys:3905591|MetaCyc:4-HYDROXYPHENYLACETATE	hp.json	2-(4-hydroxyphenyl)ethanoate|(4-hydroxyphenyl)acetate|4-hydroxybenzeneacetate|4-hydroxyphenylacetate|(p-hydroxyphenyl)acetate	http://purl.obolibrary.org/obo/CHEBI_48999		3_STAR
HP:0030275	biolink:PhenotypicFeature	Ectopic scrotum	Scrotum in a position other than the usual position inferior to the base of the penis.	UMLS:C4022542	hp.json	Abnormal scrotum position	http://purl.obolibrary.org/obo/HP_0030275		
GO:0045578	biolink:BiologicalProcess	negative regulation of B cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of B cell differentiation.		hp.json	down regulation of B cell differentiation|inhibition of B cell differentiation|negative regulation of B cell development|down-regulation of B cell differentiation|negative regulation of B-cell differentiation|negative regulation of B lymphocyte differentiation|negative regulation of B-lymphocyte differentiation|downregulation of B cell differentiation	http://purl.obolibrary.org/obo/GO_0045578		
HP:0030276	biolink:PhenotypicFeature	obsolete Small scrotum			hp.json		http://purl.obolibrary.org/obo/HP_0030276		
GO:0045579	biolink:BiologicalProcess	positive regulation of B cell differentiation	Any process that activates or increases the frequency, rate or extent of B cell differentiation.		hp.json	positive regulation of B-lymphocyte differentiation|upregulation of B cell differentiation|positive regulation of B cell development|stimulation of B cell differentiation|up regulation of B cell differentiation|positive regulation of B-cell differentiation|positive regulation of B lymphocyte differentiation|activation of B cell differentiation|up-regulation of B cell differentiation	http://purl.obolibrary.org/obo/GO_0045579		
HP:0030277	biolink:PhenotypicFeature	Abnormal vertebral pedicle morphology	Abnormal morphology of a vertebral pedical.	UMLS:C4022541	hp.json		http://purl.obolibrary.org/obo/HP_0030277		
HP:0030278	biolink:PhenotypicFeature	Hypoplastic vertebral pedicle	Underdeveloped vertebral pedicle.	UMLS:C4022540	hp.json		http://purl.obolibrary.org/obo/HP_0030278		
GO:0045577	biolink:BiologicalProcess	regulation of B cell differentiation	Any process that modulates the frequency, rate or extent of B cell differentiation.		hp.json	regulation of B-cell differentiation|regulation of B lymphocyte differentiation|regulation of B-lymphocyte differentiation|regulation of B cell development	http://purl.obolibrary.org/obo/GO_0045577		
HP:0030271	biolink:PhenotypicFeature	Reduced erythrocyte 2,3-diphosphoglycerate concentration	This term refers to an inappropriate low 2,3-DPG concentration in erythrocytes. 2,3-diphosphoglycerate (2,3-DPG) controls the movement of oxygen from red blood cells to tissues. Anemia is usually accompanied by an increased level of 2,3-DPG in order to promote tissue oxygenation.	UMLS:C4022546	hp.json		http://purl.obolibrary.org/obo/HP_0030271		
HP:0030272	biolink:PhenotypicFeature	Abnormal erythrocyte enzyme level	An altered level of any enzyme to act as catalysts within erythrocytes. This term includes changes due to altered activity of an enzyme.	UMLS:C4022545	hp.json		http://purl.obolibrary.org/obo/HP_0030272		
HP:0030273	biolink:PhenotypicFeature	Reduced red cell adenosine deaminase level	Decrease in the level of adenosine deaminase (ADA), an enzyme involved in purine metabolism, within erythrocytes. ADA is involved in the catabolism of adenosine.	UMLS:C4022544	hp.json		http://purl.obolibrary.org/obo/HP_0030273		
HP:0030274	biolink:PhenotypicFeature	Accessory scrotum	Additional scrotum, or part of a scrotum in an abnormal location.	UMLS:C4022543	hp.json	Extra scrotum	http://purl.obolibrary.org/obo/HP_0030274		
HP:0030279	biolink:PhenotypicFeature	Hypoplastic L5 vertebral pedicle	Underdeveloped pedicle of the fifth lumbar vertebra.	UMLS:C4022539	hp.json		http://purl.obolibrary.org/obo/HP_0030279		
CHEBI:58314	biolink:ChemicalSubstance	(2R)-2-hydroxy monocarboxylic acid anion	A hydroxy monocarboxylic acid anion where the hydroxy group is placed at position 2 (alpha to the carboxy group) and has (R)-stereochemistry; major species at pH 7.3.	MetaCyc:2R-hydroxy-carboxylates	hp.json	(2R)-2-hydroxy monocarboxylic acid anions|(2R)-alpha-hydroxy monocarboxylic acid anion|(R)-2-hydroxyacid anions|(R)-2-hydroxyacid anion|a (2R)-2-hydroxycarboxylate|(2R)-2-hydroxycarboxylate|(2R)-alpha-hydroxy monocarboxylic acid anions	http://purl.obolibrary.org/obo/CHEBI_58314		3_STAR
GO:0045581	biolink:BiologicalProcess	negative regulation of T cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation.		hp.json	negative regulation of T cell development|inhibition of T cell differentiation|down-regulation of T cell differentiation|negative regulation of T-cell differentiation|negative regulation of T lymphocyte differentiation|negative regulation of T-lymphocyte differentiation|downregulation of T cell differentiation|down regulation of T cell differentiation	http://purl.obolibrary.org/obo/GO_0045581		
GO:0045582	biolink:BiologicalProcess	positive regulation of T cell differentiation	Any process that activates or increases the frequency, rate or extent of T cell differentiation.		hp.json	upregulation of T cell differentiation|positive regulation of T cell development|up regulation of T cell differentiation|stimulation of T cell differentiation|positive regulation of T-cell differentiation|positive regulation of T lymphocyte differentiation|up-regulation of T cell differentiation|activation of T cell differentiation|positive regulation of T-lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_0045582		
HP:0030280	biolink:PhenotypicFeature	Rib gap	Radiolucent focal defect of a rib shaft.	SNOMEDCT_US:249705009|UMLS:C0426827	hp.json	Rib gap	http://purl.obolibrary.org/obo/HP_0030280		
GO:0045580	biolink:BiologicalProcess	regulation of T cell differentiation	Any process that modulates the frequency, rate or extent of T cell differentiation.		hp.json	regulation of T-cell differentiation|regulation of T lymphocyte differentiation|regulation of T-lymphocyte differentiation|regulation of T cell development	http://purl.obolibrary.org/obo/GO_0045580		
HP:0030281	biolink:PhenotypicFeature	Cervical C3/C4 vertebral fusion	Fusion of cervical vertebrae at C3 and C4, caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development.	UMLS:C4022538	hp.json		http://purl.obolibrary.org/obo/HP_0030281		
UBERON:0005913	biolink:AnatomicalEntity	zone of bone organ		FMA:10483	hp.json	bone organ zone	http://purl.obolibrary.org/obo/UBERON_0005913		
HP:0030286	biolink:PhenotypicFeature	Atrophic superior cerebellar peduncle	Atrophy of the superior cerebellar peduncle.	UMLS:C4022535	hp.json		http://purl.obolibrary.org/obo/HP_0030286		
HP:0030289	biolink:PhenotypicFeature	Flattened femoral epiphysis	An abnormal flattening of an epiphysis of femur.	UMLS:C1850642	hp.json	Flattended end part of thigh bone	http://purl.obolibrary.org/obo/HP_0030289		
HP:0030282	biolink:PhenotypicFeature	Posterior rib gap	Radiolucent focal defect of the posterior portion of a rib shaft. The 'gaps' may lead to flail chest.	UMLS:C1842696	hp.json	Dorsal rib defect	http://purl.obolibrary.org/obo/HP_0030282		
HP:0030283	biolink:PhenotypicFeature	Partial absence of the septum pellucidum	Only part of the septum pellucidum (a thin, triangular, vertical membrane separating the lateral ventricles of the brain) is present. This feature can be appreciated on magnetic resonance tomography or computed tomography of the brain.	SNOMEDCT_US:422474003|UMLS:C1827299	hp.json		http://purl.obolibrary.org/obo/HP_0030283		
HP:0030284	biolink:PhenotypicFeature	Triangular tongue	A form of macrogloassia (increased size of the tongue) characterized by a broad based root of the tongue but a small tongue tip, giving the appearance of a triangle.	UMLS:C4022537	hp.json	Triangular tongue|Triangle shaped tongue	http://purl.obolibrary.org/obo/HP_0030284		
HP:0030285	biolink:PhenotypicFeature	Splayed superior cerebellar peduncle	Abnormal splayed configuration (spreading out) of the superior cerebellar peduncle.	UMLS:C4022536	hp.json		http://purl.obolibrary.org/obo/HP_0030285		
GO:0070527	biolink:BiologicalProcess	platelet aggregation	The adhesion of one platelet to one or more other platelets via adhesion molecules.		hp.json	blood platelet aggregation|thrombocyte aggregation	http://purl.obolibrary.org/obo/GO_0070527		
HP:0032872	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with illusion	A focal cognitive seizure with illusion characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032872		
HP:0030210	biolink:PhenotypicFeature	Anti-muscle-specific tyrosine kinase antibody	The presence of autoantibodies (immunoglobulins) in the serum that react against muscle specific kinase (anti-MuSK Ab).	UMLS:C4021044	hp.json	Muscle specific kinase antibody positivity|Anti-muscle-specific tyrosine kinase antibody|Anti-MUSK antibodies	http://purl.obolibrary.org/obo/HP_0030210		
HP:0032871	biolink:PhenotypicFeature	Focal aware cognitive seizure with hallucination	A focal cognitive seizure with hallucination characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032871		
HP:0032874	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with auditory agnosia	A focal cognitive seizure with auditory agnosia characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032874		
HP:0030211	biolink:PhenotypicFeature	Slow pupillary light response	Reduced velocity and acceleration in the pupillary light response.	UMLS:C4022576	hp.json	Sluggish pupillary reaction	http://purl.obolibrary.org/obo/HP_0030211		
HP:0030212	biolink:PhenotypicFeature	Collectionism	Excessive or pathological tendency to save and collect possessions.	UMLS:C0424290|SNOMEDCT_US:247968005	hp.json	Compulsive hoarding	http://purl.obolibrary.org/obo/HP_0030212		
HP:0032873	biolink:PhenotypicFeature	Focal aware sensory seizure with cephalic sensation	A seizure characterized by a sensation in the head such as light-headedness or headache.		hp.json		http://purl.obolibrary.org/obo/HP_0032873		
HP:0032870	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with dyslexia/alexia	A focal cognitive seizure with dyslexia / alexia characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032870		
HP:0030217	biolink:PhenotypicFeature	Limb apraxia	Difficulty in performing the correct execution of limbs movements in absence of motor impairment.	UMLS:C4022574	hp.json		http://purl.obolibrary.org/obo/HP_0030217		
HP:0032879	biolink:PhenotypicFeature	Focal impaired awareness seizure with dissociation at onset	A focal cognitive seizure with dissociation at the onset of the seizure impairment of awareness at at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032879		
HP:0030218	biolink:PhenotypicFeature	Punding	Punding is a stereotypical motor behavior characterized by an intense fascination with repetitive, excessive and non-goal oriented handling, and examining of objects.	UMLS:C1963933	hp.json		http://purl.obolibrary.org/obo/HP_0030218		
HP:0030219	biolink:PhenotypicFeature	Semantic dementia	A progressive loss of the ability to remember the meaning of words, faces and objects.	SNOMEDCT_US:230288001|MSH:D057180|UMLS:C0338462	hp.json	Trouble remembering words	http://purl.obolibrary.org/obo/HP_0030219		
HP:0005246	biolink:PhenotypicFeature	Giant hypertrophic gastritis	A type of gastritis characterized by excessive proliferation of the gastric mucosa and diffuse thickening of the gastric mucosal folds.	UMLS:C0017155|MSH:D005758|SNOMEDCT_US:413219009|SNOMEDCT_US:60002000	hp.json	Menetrier disease	http://purl.obolibrary.org/obo/HP_0005246		
HP:0032876	biolink:PhenotypicFeature	Focal aware cognitive seizure with conduction dysphasia/aphasia	A focal cognitive seizure with conduction dysphasia / aphasia characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032876		
HP:0030213	biolink:PhenotypicFeature	Emotional blunting	Lack of emotional reactivity and empathy for situations or persons, sometime also for family members.	UMLS:C0233469|SNOMEDCT_US:6140007	hp.json		http://purl.obolibrary.org/obo/HP_0030213		
HP:0030214	biolink:PhenotypicFeature	Hypersexuality	Pathological persistent sexual disinhibiting behavior, directed at oneself or to others.	UMLS:C0312420|UMLS:C0679145|SNOMEDCT_US:73744004	hp.json	Sex addiction	http://purl.obolibrary.org/obo/HP_0030214		
HP:0005247	biolink:PhenotypicFeature	Hypoplasia of the abdominal wall musculature	Underdevelopment of the abdominal musculature.	UMLS:C3279407	hp.json	Abdominal muscular hypoplasia	http://purl.obolibrary.org/obo/HP_0005247		
HP:0032875	biolink:PhenotypicFeature	obsolete Focal impaired awareness cognitive seizure with impaired responsiveness			hp.json		http://purl.obolibrary.org/obo/HP_0032875		
HP:0005248	biolink:PhenotypicFeature	Intrahepatic biliary atresia	Atresia in the intrahepatic bile duct.	UMLS:C1855284	hp.json	Intrahepatic atresia of biliary duct|Bile duct paucity	http://purl.obolibrary.org/obo/HP_0005248		
HP:0030215	biolink:PhenotypicFeature	Inappropriate crying	Uncontrolled episodes of crying, without apparent motivating stimuli.	UMLS:C0860609	hp.json	Inappropriate crying	http://purl.obolibrary.org/obo/HP_0030215		
HP:0032878	biolink:PhenotypicFeature	Focal impaired awareness sensory seizure with cephalic sensation	A focal sensory seizure with cephalic sensation in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032878		
HP:0030216	biolink:PhenotypicFeature	Inertia	Reduction of goal-directed behaviors linked to the impairment in frontal executive functions (planning of an action for example).	UMLS:C4022575	hp.json		http://purl.obolibrary.org/obo/HP_0030216		
HP:0032877	biolink:PhenotypicFeature	Focal aware sensory seizure with hot-cold sensations	A seizure characterized by sensations of feeling hot and then cold.		hp.json		http://purl.obolibrary.org/obo/HP_0032877		
HP:0005249	biolink:PhenotypicFeature	Functional intestinal obstruction		UMLS:C3639956	hp.json		http://purl.obolibrary.org/obo/HP_0005249		
HP:0005242	biolink:PhenotypicFeature	Extrahepatic biliary duct atresia	Atresia in the extrahepatic bile duct.	UMLS:C0005411|MSH:D001656|SNOMEDCT_US:82821008|SNOMEDCT_US:77480004	hp.json	Biliary atresia, extrahepatic	http://purl.obolibrary.org/obo/HP_0005242		
HP:0005243	biolink:PhenotypicFeature	Partial abdominal muscle agenesis	Failure to form of portions of the abdominal musculature.	UMLS:C4025228	hp.json		http://purl.obolibrary.org/obo/HP_0005243		
HP:0005244	biolink:PhenotypicFeature	Gastrointestinal infarctions		UMLS:C3152231	hp.json	GI infarctions|Death of digestive organ tissue due to poor blood supply	http://purl.obolibrary.org/obo/HP_0005244		
HP:0005245	biolink:PhenotypicFeature	Intestinal hypoplasia	Developmental hypoplasia of the intestine.	UMLS:C4021640	hp.json	Hypoplastic intestines|Underdeveloped instestine	http://purl.obolibrary.org/obo/HP_0005245		
HP:0005240	biolink:PhenotypicFeature	Esophageal obstruction		SNOMEDCT_US:405247003|UMLS:C0239296	hp.json		http://purl.obolibrary.org/obo/HP_0005240		
HP:0005241	biolink:PhenotypicFeature	Total intestinal aganglionosis	A congenital defect characterized by the lack of ganglion cells in the entire intestine, i.e., the aganglionic segment comprises the entire large and small bowel.	SNOMEDCT_US:204745000|MSH:C538058|UMLS:C0345240	hp.json		http://purl.obolibrary.org/obo/HP_0005241		
HP:0032883	biolink:PhenotypicFeature	Focal aware cognitive seizure with deja vu/jamais vu	A focal cognitive seizure with deja vu / jamais vu characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032883		
HP:0030220	biolink:PhenotypicFeature	Socially inappropriate behavior	Behavior that is not in line with social norms.	UMLS:C2220010	hp.json	Socially inappropriate behaviour|Socially inappropriate behavior	http://purl.obolibrary.org/obo/HP_0030220		
HP:0030221	biolink:PhenotypicFeature	Sweet craving	Excessive desire to eat sweet foods.	UMLS:C0241314	hp.json	Sweet craving	http://purl.obolibrary.org/obo/HP_0030221		
HP:0032882	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with deja vu/jamais vu	A focal cognitive seizure with deja vu / jamais vu characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032882		
HP:0030222	biolink:PhenotypicFeature	Visual agnosia	Difficulty in recognizing objects by visual input in absence of sensorial visual impairment.	MSH:D000377|SNOMEDCT_US:25762009|UMLS:C0234502	hp.json		http://purl.obolibrary.org/obo/HP_0030222		
HP:0032885	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with hallucination	A focal cognitive seizure with hallucination characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032885		
HP:0030223	biolink:PhenotypicFeature	Perseveration	Perseveration can be defined as the contextually inappropriate and unintentional repetition of a response or behavioral unit. In other words, the observed repetitiveness does not meet the demands of the situation, is not the product of deliberation, and may even unfold despite counterintention. Perseveration can therefore be differentiated from goal-directed and intentional forms of repetition, such as linguistic redundancies designed to enhance communicative or poetic impact.	SNOMEDCT_US:44515000|UMLS:C0233651	hp.json	Perseverative behavior|Perseverative behaviour	http://purl.obolibrary.org/obo/HP_0030223		
HP:0032884	biolink:PhenotypicFeature	Focal aware sensory seizure with somatosensory features	A seizure characterized by sensory phenomena including tingling, numbness, electric-shock like sensation, pain, sense of movement, or desire to move. Awareness is retained throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032884		
HP:0032881	biolink:PhenotypicFeature	obsolete Focal aware cognitive seizure with impaired responsiveness			hp.json		http://purl.obolibrary.org/obo/HP_0032881		
HP:0032880	biolink:PhenotypicFeature	Focal impaired awareness sensory seizure with auditory features	A focal sensory seizure with auditory features in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032880		
HP:0030228	biolink:PhenotypicFeature	Abnormal muscle fiber valosin-containing protein	A deviation from normal in the expression of valosin-containing protein in muscle tissue. Valosin-containing protein is an ubiquitously expressed multifunctional 100-kD protein that is a member of the AAA+ (ATPase associated with various activities) protein family.	UMLS:C4022570	hp.json	Abnormal muscle fibre valosin-containing protein	http://purl.obolibrary.org/obo/HP_0030228		
HP:0030229	biolink:PhenotypicFeature	Accumulation of muscle fiber valosin-containing protein	Immunohistochemistry shows accumulation of valosin-containing protein in the muscle biopsy.	UMLS:C4022569	hp.json	Accumulation of muscle fibre valosin-containing protein	http://purl.obolibrary.org/obo/HP_0030229		
HP:0030224	biolink:PhenotypicFeature	Abnormal muscle fiber desmin	A deviation from normal in the expression of desmin in muscle tissue. Desmin is an 53-KDa protein.	UMLS:C4022573	hp.json	Abnormal muscle fibre desmin	http://purl.obolibrary.org/obo/HP_0030224		
HP:0005257	biolink:PhenotypicFeature	Thoracic hypoplasia		UMLS:C1837482	hp.json	Small chest|Small thorax	http://purl.obolibrary.org/obo/HP_0005257		
HP:0032887	biolink:PhenotypicFeature	Generalized atonic seizure	Generalized atonic seizure is a type of generalized motor seizure characterized by a sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic event lasting about 1-2 s, involving head, trunk, jaw, or limb musculature.		hp.json	Generalised atonic seizure	http://purl.obolibrary.org/obo/HP_0032887		
HP:0005258	biolink:PhenotypicFeature	Pectoral muscle hypoplasia/aplasia		UMLS:C4025226	hp.json	Small/absent pec muscle|Underdeveloped/absent pec muscle	http://purl.obolibrary.org/obo/HP_0005258		
HP:0030225	biolink:PhenotypicFeature	Accumulation of muscle fiber desmin	Immunohistochemistry shows accumulation of desmin protein in the muscle biopsy.	UMLS:C4021043	hp.json	Muscle fiber desmin-reactive inclusion bodies|Accumulation of muscle fibre desmin|Muscle fibre desmin-reactive inclusion bodies	http://purl.obolibrary.org/obo/HP_0030225		
HP:0032886	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with expressive dysphasia/aphasia	A focal cognitive seizure with expressive dysphasia / aphasia characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032886		
HP:0032889	biolink:PhenotypicFeature	Focal aware sensory seizure with gustatory features	A seizure characterized by taste phenomena including acidic, bitter, salty, sweet, or metallic tastes.		hp.json		http://purl.obolibrary.org/obo/HP_0032889		
HP:0030226	biolink:PhenotypicFeature	Abnormal muscle fiber myotilin	A deviation from normal in the expression of myotilin in muscle tissue. Myotilin is a 57kD cytoskeletal protein.	UMLS:C4022572	hp.json	Abnormal muscle fibre myotilin	http://purl.obolibrary.org/obo/HP_0030226		
HP:0005259	biolink:PhenotypicFeature	Abnormal facility in opposing the shoulders		UMLS:C1861517	hp.json		http://purl.obolibrary.org/obo/HP_0005259		
HP:0030227	biolink:PhenotypicFeature	Accumulation of muscle fiber myotilin	Immunohistochemistry shows accumulation of myotilin protein in the muscle biopsy.	UMLS:C4022571	hp.json	Accumulation of muscle fibre myotilin	http://purl.obolibrary.org/obo/HP_0030227		
HP:0032888	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with forced thinking	A focal cognitive seizure with forced thinking characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032888		
HP:0005253	biolink:PhenotypicFeature	Increased anterioposterior diameter of thorax		UMLS:C1848760	hp.json	Increased anterioposterior diameter of chest	http://purl.obolibrary.org/obo/HP_0005253		
HP:0005254	biolink:PhenotypicFeature	Unilateral chest hypoplasia		UMLS:C1845576	hp.json	Small chest on one side|Underdeveloped chest on one side	http://purl.obolibrary.org/obo/HP_0005254		
HP:0005255	biolink:PhenotypicFeature	Absence of pectoralis minor muscle	Aplasia (congenital absence) of the pectoralis minor.	UMLS:C1868158	hp.json	Pectoralis minor aplasia	http://purl.obolibrary.org/obo/HP_0005255		
HP:0005256	biolink:PhenotypicFeature	Unilateral absence of pectoralis major muscle	Aplasia (congenital absence) of the pectoralis minor on only one side of the chest.	UMLS:C4021639	hp.json	Unilateral aplasia of pectoralis major muscle	http://purl.obolibrary.org/obo/HP_0005256		
HP:0005250	biolink:PhenotypicFeature	High intestinal obstruction		UMLS:C4025227	hp.json		http://purl.obolibrary.org/obo/HP_0005250		
HP:0030231	biolink:PhenotypicFeature	Glycogen accumulation in muscle fiber lysosomes	An increased amount of glycogen in muscle tissue found specifically in lysosomes.	UMLS:C4022567	hp.json	Glycogen accumulation in muscle fibre lysosomes	http://purl.obolibrary.org/obo/HP_0030231		
HP:0032894	biolink:PhenotypicFeature	Seizure precipitated by febrile infection	Any form of seizure occurring at the time of a fever (temperature at or above 38.0 degrees Celcius) without infection of the central nervous system, and without an alternative cause such as severe metabolic derangement, occurring at any age.		hp.json	Fever induced seizure	http://purl.obolibrary.org/obo/HP_0032894		
HP:0030232	biolink:PhenotypicFeature	Increased sarcoplasmic glycogen	Elevated glycogen content in the sarcoplasm (cytoplasm) of muscle fibers.	UMLS:C4022566	hp.json		http://purl.obolibrary.org/obo/HP_0030232		
HP:0032893	biolink:PhenotypicFeature	Gastroenteritis-related afebrile seizure	Afebrile (less than 38.0 degrees Celcius), brief, and generalized seizures accompanying gastroenteritis without an alternative cause.		hp.json		http://purl.obolibrary.org/obo/HP_0032893		
HP:0030233	biolink:PhenotypicFeature	Bethlem sign	Limitation of wrist and finger extension on asking patient to form a prayer sign. This is a result of progressive wrist and finger flexion contractures.	UMLS:C4021042	hp.json	Bethlem phenomenon	http://purl.obolibrary.org/obo/HP_0030233		
HP:0032896	biolink:PhenotypicFeature	Music-induced seizure	Seizure precipitated by listening to music or other complex sounds.		hp.json		http://purl.obolibrary.org/obo/HP_0032896		
HP:0030234	biolink:PhenotypicFeature	Highly elevated creatine kinase	An increased CPK level between 4X and 50X above the upper normal level.	UMLS:C4022565	hp.json	Highly elevated CPK|Highly elevated serum CK|Highly elevated serum phosph-CK|Highly elevated serum CPK|Highly elevated creatine phosphokinase	http://purl.obolibrary.org/obo/HP_0030234		
HP:0032895	biolink:PhenotypicFeature	Febrile seizure outside the age of 3 months to 6 years	Any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38.0 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in people beyond the typical arrange of 3 months-6 years with no prior history of afebrile seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032895		
HP:0032890	biolink:PhenotypicFeature	Focal impaired awareness sensory seizure with somatosensory features	A focal sensory seizure with somatosensory features in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032890		
HP:0032892	biolink:PhenotypicFeature	Infection-related seizure	Seizure associated with a presumed or proven infection (excluding infection of the central nervous system) or inflammatory state without an alternative precipitant such as metabolic derangement, and regardless of the presence or absence of a fever.		hp.json		http://purl.obolibrary.org/obo/HP_0032892		
HP:0032891	biolink:PhenotypicFeature	Focal aware motor seizure with version	A focal motor seizure with version characterized by retained awareness throughout the seizure.		hp.json	Focal motor aware seizure with version	http://purl.obolibrary.org/obo/HP_0032891		
HP:0030230	biolink:PhenotypicFeature	Central core regions in muscle fibers	The presence of disorganized areas called cores in the center of muscle fibers. There is a typical appearance of the biopsy on light microscopy, where the muscle cells have cores that are devoid of mitochondria and specific enzymes. Cores are typically well demarcated and centrally located, but may occasionally be multiple and of eccentric.	UMLS:C4022568	hp.json	Central core regions in muscle fibres	http://purl.obolibrary.org/obo/HP_0030230		
HP:0030239	biolink:PhenotypicFeature	Hypoplasia of the upper arm musculature	Underdevelopment of the musculature of the upper arm, which may include the deltoid, the triceps, the biceps, and the brachioradialis.	UMLS:C4022562	hp.json	Underdeveloped upper arm muscles	http://purl.obolibrary.org/obo/HP_0030239		
HP:0005229	biolink:PhenotypicFeature	Jejunoileal ulceration		UMLS:C4025232	hp.json		http://purl.obolibrary.org/obo/HP_0005229		
HP:0005224	biolink:PhenotypicFeature	Rectal abscess	A collection of pus in the area of the rectum.	SNOMEDCT_US:197166005|SNOMEDCT_US:91669008|UMLS:C0267566|UMLS:C0149770	hp.json	Perirectal abscess	http://purl.obolibrary.org/obo/HP_0005224		
HP:0030235	biolink:PhenotypicFeature	Extremely elevated creatine kinase	An increased creatine kinase level more than 50X above the upper normal level.	UMLS:C4022564	hp.json	Extremely high CPK level|Extremely elevated creatine phosphokinase|Extremely elevated phospho-CK serum level|Extremely elevated serum CK level|Extremely elevated CPK	http://purl.obolibrary.org/obo/HP_0030235		
HP:0032898	biolink:PhenotypicFeature	Focal automatism seizure	A focal seizure characterized at onset by coordinated motor activity. This often resembles a voluntary movement and may consist of an inappropriate continuation of preictal motor activity.		hp.json		http://purl.obolibrary.org/obo/HP_0032898		
HP:0007886	biolink:PhenotypicFeature	Absent extraocular muscles	Congenital absence of the extraocular muscles.	UMLS:C1408781|UMLS:C4024777	hp.json	Absent ocular muscles|Missing eye muscles	http://purl.obolibrary.org/obo/HP_0007886		
HP:0030236	biolink:PhenotypicFeature	Abnormality of muscle size	Abnormalities of the overall muscle bulk based on clinical observation.	UMLS:C4022563	hp.json	Abnormality of muscle size	http://purl.obolibrary.org/obo/HP_0030236		
HP:0032897	biolink:PhenotypicFeature	Focal impaired awareness sensory seizure with gustatory features	A focal sensory seizure with gustatory features in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032897		
HP:0005225	biolink:PhenotypicFeature	Intestinal edema	Accumulation of cell free, noninflammatony fluid within the wall of the intestinal tract producing uniform thickening of the mucosal folds.	UMLS:C1142262	hp.json	Intestinal oedema	http://purl.obolibrary.org/obo/HP_0005225		
HP:0030237	biolink:PhenotypicFeature	Hand muscle weakness	Reduced strength of the musculature of the hand.	SNOMEDCT_US:298283006|UMLS:C0239831	hp.json	Hand muscle weakness	http://purl.obolibrary.org/obo/HP_0030237		
HP:0007889	biolink:PhenotypicFeature	Iridescent posterior subcapsular cataract	A type of posterior subcapsular cataract characterized by an iridescent color.	UMLS:C1864573	hp.json	Cataracts, posterior, subcapsular, iridescent	http://purl.obolibrary.org/obo/HP_0007889		
HP:0032899	biolink:PhenotypicFeature	Focal orofacial automatism seizure	A type of focal automatism seizure characterized by orofacial automatisms at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032899		
HP:0005227	biolink:PhenotypicFeature	Adenomatous colonic polyposis	Presence of multiple adenomatous polyps in the colon.	UMLS:C1868071|MEDDRA:10056981	hp.json	Multiple adenomatous colon polyps|Multiple colonic adenomatous polyps	http://purl.obolibrary.org/obo/HP_0005227		
HP:0005220	biolink:PhenotypicFeature	Multiple intestinal neurofibromatosis		UMLS:C4025233	hp.json		http://purl.obolibrary.org/obo/HP_0005220		
HP:0005222	biolink:PhenotypicFeature	Bowel diverticulosis	The presence of multiple diverticula of the intestine.	UMLS:C1395674|UMLS:C1394691	hp.json	Bowel diverticula	http://purl.obolibrary.org/obo/HP_0005222		
HP:0007885	biolink:PhenotypicFeature	Slowed horizontal saccades	An abnormally slow velocity of horizontal saccadic eye movements.	UMLS:C1856477	hp.json		http://purl.obolibrary.org/obo/HP_0007885		
HP:0005223	biolink:PhenotypicFeature	Duplicated colon		UMLS:C1850328	hp.json		http://purl.obolibrary.org/obo/HP_0005223		
HP:0007881	biolink:PhenotypicFeature	Central corneal dystrophy		UMLS:C4024778	hp.json		http://purl.obolibrary.org/obo/HP_0007881		
HP:0007880	biolink:PhenotypicFeature	Marginal corneal dystrophy		UMLS:C4024779	hp.json		http://purl.obolibrary.org/obo/HP_0007880		
CHEBI:71300	biolink:ChemicalSubstance	EC 2.* (transferase) inhibitor	An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)	Wikipedia:Transferase	hp.json	EC 2.* inhibitors|EC 2 inhibitor|EC 2 inhibitors|EC 2.* inhibitor|EC 2.* (transferase) inhibitors|transferase inhibitor|transferase inhibitors	http://purl.obolibrary.org/obo/CHEBI_71300		3_STAR
GO:0021593	biolink:BiologicalProcess	rhombomere morphogenesis	The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.		hp.json		http://purl.obolibrary.org/obo/GO_0021593		
GO:0021594	biolink:BiologicalProcess	rhombomere formation	The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.		hp.json		http://purl.obolibrary.org/obo/GO_0021594		
HP:0030242	biolink:PhenotypicFeature	Portal vein thrombosis	Thrombosis of the portal vein and/or its tributaries, which include the splenic vein and the superior and inferior mesenteric veins.	SNOMEDCT_US:17920008|UMLS:C0155773	hp.json	Blood clot in portal vein	http://purl.obolibrary.org/obo/HP_0030242		
HP:0030243	biolink:PhenotypicFeature	Hepatic vein thrombosis	An obstruction in the veins of the liver caused by a blood clot (thrombosis).	UMLS:C0019154|SNOMEDCT_US:38739001|MSH:D006502	hp.json	Hepatic venous thrombosis|Blood clot in liver vein	http://purl.obolibrary.org/obo/HP_0030243		
HP:0030244	biolink:PhenotypicFeature	Maternal fever in pregnancy	The occurence of an elevated body temperature of the mother during pregnancy.	UMLS:C4021041	hp.json	Maternal fever during pregnancy	http://purl.obolibrary.org/obo/HP_0030244		
HP:0030245	biolink:PhenotypicFeature	Intrapartum fever	The occurence of maternal fever during labor.	UMLS:C3829514	hp.json	Maternal fever during labour|Maternal fever during labor	http://purl.obolibrary.org/obo/HP_0030245		
HP:0030241	biolink:PhenotypicFeature	Hypoplasia of deltoid muscle	Underdevelopment of the deltoid muscle.	UMLS:C1868170	hp.json	Deltoid muscle hypoplasia	http://purl.obolibrary.org/obo/HP_0030241		
HP:0005235	biolink:PhenotypicFeature	Jejunal atresia	A developmental defect resulting in abnormal closure, or atresia of the tubular structure of the jejunum.	SNOMEDCT_US:204702007|UMLS:C0266175|SNOMEDCT_US:360491009|MSH:D007409	hp.json		http://purl.obolibrary.org/obo/HP_0005235		
HP:0007898	biolink:PhenotypicFeature	Exudative retinopathy		MSH:D058456|SNOMEDCT_US:360455002|SNOMEDCT_US:25506007|UMLS:C0154832	hp.json		http://purl.obolibrary.org/obo/HP_0007898		
HP:0030246	biolink:PhenotypicFeature	Maternal first trimester fever	The occurence of fever in a mother during the first trimester of pregnancy.	UMLS:C4022561	hp.json		http://purl.obolibrary.org/obo/HP_0030246		
HP:0005236	biolink:PhenotypicFeature	Chronic calcifying pancreatitis	A form of chronic pancreatitis that is characterized by calcification.	UMLS:C4025231	hp.json		http://purl.obolibrary.org/obo/HP_0005236		
HP:0030247	biolink:PhenotypicFeature	Splanchnic vein thrombosis	The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (hepatic vein thrombosis), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis; the word splanchnic is used to refer to the visceral organs (of the abdominal cavity).	UMLS:C4022560	hp.json	Blood clot in splanchnic vein	http://purl.obolibrary.org/obo/HP_0030247		
HP:0030248	biolink:PhenotypicFeature	Mesenteric venous thrombosis	A clot that obstructs blood flow in a mesenteric vein (the superior and the inferior mesenteric vein drain blood from the small and large intestine).	SNOMEDCT_US:95446005|UMLS:C0267412|MSH:D065666	hp.json	Blood clot in mesentertic vein	http://purl.obolibrary.org/obo/HP_0030248		
HP:0005237	biolink:PhenotypicFeature	Degenerative liver disease	The presence of degenerative changes of the liver.	UMLS:C4025230	hp.json		http://purl.obolibrary.org/obo/HP_0005237		
HP:0007899	biolink:PhenotypicFeature	Retinal nonattachment	Failure of attachment of the retina during development.	UMLS:C4021563	hp.json	Congenital retinal non-attachment	http://purl.obolibrary.org/obo/HP_0007899		
HP:0005238	biolink:PhenotypicFeature	Discrete intestinal polyps		UMLS:C4025229	hp.json		http://purl.obolibrary.org/obo/HP_0005238		
HP:0030249	biolink:PhenotypicFeature	Enanthema	A sudden eruption (rash) of the surface of a mucous membrane of the mouth or pharynx.	SNOMEDCT_US:5862001|UMLS:C0014034	hp.json		http://purl.obolibrary.org/obo/HP_0030249		
HP:0005231	biolink:PhenotypicFeature	Chronic gastritis	A chronic form of gastritis.	SNOMEDCT_US:8493009|UMLS:C0085695	hp.json		http://purl.obolibrary.org/obo/HP_0005231		
HP:0007894	biolink:PhenotypicFeature	Hypopigmentation of the fundus	Reduced pigmentation of the fundus, typically generalised. Fundoscopy may reveal a low level pigment in both RPE and choroid with clear visibility of choroidal vessels (pale/albinoid) or low pigment level in the RPE with deep pigment in choroid so that visible choroidal vessels are separated by deeply pigmented zones (tesselated/tigroid).	UMLS:C0151891|SNOMEDCT_US:95694000	hp.json	Decreased fundus pigmentation|Fundus hypopigmentation	http://purl.obolibrary.org/obo/HP_0007894		
HP:0005232	biolink:PhenotypicFeature	Pancreatic dysplasia	The presence of developmental dysplasia of the pancreas.	UMLS:C4019084	hp.json		http://purl.obolibrary.org/obo/HP_0005232		
HP:0007893	biolink:PhenotypicFeature	obsolete Progressive retinal degeneration			hp.json		http://purl.obolibrary.org/obo/HP_0007893		
HP:0005233	biolink:PhenotypicFeature	Hypoplasia of the gallbladder	The presence of a hypoplastic gallbladder.	SNOMEDCT_US:93259002|UMLS:C0345282	hp.json	Hypoplastic gallbladder	http://purl.obolibrary.org/obo/HP_0005233		
HP:0005234	biolink:PhenotypicFeature	Neonatal intestinal obstruction		UMLS:C0859974	hp.json		http://purl.obolibrary.org/obo/HP_0005234		
HP:0007892	biolink:PhenotypicFeature	Hypoplasia of the lacrimal punctum	Underdevelopment of the lacrimal puncta.	UMLS:C4021564	hp.json	Hypoplasia of the lacrimal puncta|Hypoplastic lacrimal puncta	http://purl.obolibrary.org/obo/HP_0007892		
HP:0005230	biolink:PhenotypicFeature	Biliary tract obstruction	Obstruction affecting the biliary tree.	UMLS:C0400979|SNOMEDCT_US:235918000	hp.json		http://purl.obolibrary.org/obo/HP_0005230		
OBO:MAXO_0000383	biolink:NamedThing	biopsy of vulva	Removal of tissue from the mammalian vulva.		hp.json	vulva biopsy|mammalian vulva biopsy|vulval biopsy	http://purl.obolibrary.org/obo/MAXO_0000383		
HP:0005290	biolink:PhenotypicFeature	Internal carotid artery hypoplasia		UMLS:C4280493|UMLS:C4280492|UMLS:C4280491|UMLS:C1855736	hp.json	Hypotrophic internal carotid artery|Decreased size of internal carotid artery|Deficiency of internal carotid artery|Small internal carotid artery|Aplasia of internal carotid artery	http://purl.obolibrary.org/obo/HP_0005290		
OBO:MAXO_0000384	biolink:NamedThing	biopsy of medulla oblongata	Removal of tissue from the medulla oblongata.		hp.json	medulla oblongata biopsy	http://purl.obolibrary.org/obo/MAXO_0000384		
GO:0021582	biolink:BiologicalProcess	medulla oblongata maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.		hp.json	myelencephalon maturation|medulla maturation	http://purl.obolibrary.org/obo/GO_0021582		
GO:0021583	biolink:BiologicalProcess	pons morphogenesis	The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.		hp.json		http://purl.obolibrary.org/obo/GO_0021583		
OBO:MAXO_0000381	biolink:NamedThing	biopsy of lymph node	Removal of tissue from the lymph node.		hp.json	lymph node biopsy	http://purl.obolibrary.org/obo/MAXO_0000381		
HP:0005291	biolink:PhenotypicFeature	Inflammatory arteriopathy		UMLS:C4025222	hp.json		http://purl.obolibrary.org/obo/HP_0005291		
OBO:MAXO_0000382	biolink:NamedThing	biopsy of lymphatic part of lymphoid system	Removal of tissue from the lymphatic part of lymphoid system.		hp.json	lymphatic part of lymphoid system biopsy	http://purl.obolibrary.org/obo/MAXO_0000382		
GO:0021584	biolink:BiologicalProcess	pons formation	The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.		hp.json		http://purl.obolibrary.org/obo/GO_0021584		
HP:0005292	biolink:PhenotypicFeature	Intimal thickening in the coronary arteries		UMLS:C1968633	hp.json		http://purl.obolibrary.org/obo/HP_0005292		
OBO:MAXO_0000387	biolink:NamedThing	biopsy of muscle tissue	Removal of tissue from the muscle tissue.		hp.json	muscle tissue biopsy	http://purl.obolibrary.org/obo/MAXO_0000387		
OBO:MAXO_0000388	biolink:NamedThing	biopsy of nasolacrimal duct	Removal of tissue from the nasolacrimal duct.		hp.json	nasolacrimal duct biopsy	http://purl.obolibrary.org/obo/MAXO_0000388		
GO:0021586	biolink:BiologicalProcess	pons maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.		hp.json		http://purl.obolibrary.org/obo/GO_0021586		
OBO:MAXO_0000385	biolink:NamedThing	biopsy of mouth	Removal of tissue from the mouth.		hp.json	mouth biopsy|muscle biopsy	http://purl.obolibrary.org/obo/MAXO_0000385		
OBO:MAXO_0000386	biolink:NamedThing	biopsy of muscle	Removal of tissue from the muscle organ.		hp.json	muscle organ biopsy	http://purl.obolibrary.org/obo/MAXO_0000386		
HP:0032830	biolink:PhenotypicFeature	Neonatal seizure with bilateral asymmetric automatism	Neonatal seizure with bilateral asymmetric automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with coordinated motor activity, typically oral, usually with impaired awareness, occurring at both sides of the body asymmetrically.		hp.json		http://purl.obolibrary.org/obo/HP_0032830		
OBO:MAXO_0000380	biolink:NamedThing	biopsy of lung	Removal of tissue from the lung.		hp.json	lung biopsy	http://purl.obolibrary.org/obo/MAXO_0000380		
GO:0021580	biolink:BiologicalProcess	medulla oblongata formation	The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.		hp.json	myelencephalon biosynthesis|medulla formation|medulla biosynthesis|myelencephalon formation	http://purl.obolibrary.org/obo/GO_0021580		
HP:0032836	biolink:PhenotypicFeature	Neonatal bilateral symmetric myoclonic seizure	Neonatal bilateral symmetric myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at both sides of the body symmetrically.		hp.json		http://purl.obolibrary.org/obo/HP_0032836		
HP:0032835	biolink:PhenotypicFeature	Neonatal seizure with bilateral symmetric automatism	Neonatal seizure with bilateral asymmetric automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awarness, occurring at both sides of the body symmetrically.		hp.json		http://purl.obolibrary.org/obo/HP_0032835		
HP:0032838	biolink:PhenotypicFeature	Neonatal unilateral epileptic spasm	Neonatal unilateral epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs at one side of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0032838		
HP:0032837	biolink:PhenotypicFeature	Bilateral asymmetric neonatal sequential seizure	Asymmetric neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting asymmetrically with a variety of clinical and electrographic signs, often changing lateralization within or between seizures.		hp.json		http://purl.obolibrary.org/obo/HP_0032837		
HP:0032832	biolink:PhenotypicFeature	Neonatal bilateral asymmetric myoclonic seizure	Neonatal bilateral asymmetric myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at both sides of the body asymmetrically.		hp.json		http://purl.obolibrary.org/obo/HP_0032832		
HP:0032831	biolink:PhenotypicFeature	Neonatal bilateral asymmetric tonic seizure	Neonatal bilateral asymmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body but asymmetrically.		hp.json		http://purl.obolibrary.org/obo/HP_0032831		
HP:0032834	biolink:PhenotypicFeature	Neonatal seizure with unilateral automatism	Neonatal seizure with bilateral asymmetric automatisms is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awarness, occurring at one side of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0032834		
HP:0032833	biolink:PhenotypicFeature	Neonatal epileptic spasm	A sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. Limited forms may occur: grimacing, head nodding, or subtle eye movements. May occur in clusters.		hp.json		http://purl.obolibrary.org/obo/HP_0032833		
OBO:MAXO_0000389	biolink:NamedThing	biopsy of nasopharynx	Removal of tissue from the nasopharynx.		hp.json	nasopharynx biopsy	http://purl.obolibrary.org/obo/MAXO_0000389		
HP:0005288	biolink:PhenotypicFeature	Abnormality of the nares	Abnormality of the nostril.	UMLS:C4021637	hp.json	Abnormality of the nostrils|Malformation of the nostrils|Deformity of the nostrils|Deformity of the nares|Anomaly of the nares|Malformation of the nares	http://purl.obolibrary.org/obo/HP_0005288		hposlim_core
HP:0005289	biolink:PhenotypicFeature	Abnormality of the nasolabial region		UMLS:C4025223	hp.json	Anomaly of the nasolabial region|Deformity of the nasolabial region|Malformation of the nasolabial region	http://purl.obolibrary.org/obo/HP_0005289		
HP:0032839	biolink:PhenotypicFeature	Bilateral symmetric neonatal sequential seizure	Symmetric neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting symmetrically but with a variety of clinical and electrographic signs.		hp.json		http://purl.obolibrary.org/obo/HP_0032839		
HP:0005285	biolink:PhenotypicFeature	Absent nasal bridge		UMLS:C1837888	hp.json	Missing bridge of nose|Absent bridge of nose|Agenesis of bridge of nose|Missing nasal bridge|Absent nasal bridge|Agenesis of nasal bridge	http://purl.obolibrary.org/obo/HP_0005285		
OBO:MAXO_0000372	biolink:NamedThing	biopsy of large intestine	Removal of tissue from the large intestine.		hp.json	large intestine biopsy	http://purl.obolibrary.org/obo/MAXO_0000372		
OBO:MAXO_0000373	biolink:NamedThing	biopsy of larynx	Removal of tissue from the larynx.		hp.json	larynx biopsy	http://purl.obolibrary.org/obo/MAXO_0000373		
OBO:MAXO_0000370	biolink:NamedThing	biopsy of jaw skeleton	Removal of tissue from the jaw skeleton.		hp.json	jaw skeleton biopsy	http://purl.obolibrary.org/obo/MAXO_0000370		
OBO:MAXO_0000371	biolink:NamedThing	biopsy of lacrimal apparatus	Removal of tissue from the lacrimal apparatus.		hp.json	lacrimal apparatus biopsy	http://purl.obolibrary.org/obo/MAXO_0000371		
OBO:MAXO_0000376	biolink:NamedThing	biopsy of liver	Removal of tissue from the liver.		hp.json	liver biopsy	http://purl.obolibrary.org/obo/MAXO_0000376		
OBO:MAXO_0000377	biolink:NamedThing	biopsy of lower respiratory tract	Removal of tissue from the lower respiratory tract.		hp.json	lower respiratory tract biopsy	http://purl.obolibrary.org/obo/MAXO_0000377		
GO:0021575	biolink:BiologicalProcess	hindbrain morphogenesis	The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.		hp.json	rhombencephalon morphogenesis	http://purl.obolibrary.org/obo/GO_0021575		
GO:0033559	biolink:BiologicalProcess	unsaturated fatty acid metabolic process	The chemical reactions and pathways involving an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.	MetaCyc:PWY-762|MetaCyc:PWY-782	hp.json	unsaturated fatty acid metabolism	http://purl.obolibrary.org/obo/GO_0033559		
GO:0021576	biolink:BiologicalProcess	hindbrain formation	The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.		hp.json		http://purl.obolibrary.org/obo/GO_0021576		
OBO:MAXO_0000374	biolink:NamedThing	biopsy of limb	Removal of tissue from the limb.		hp.json	limb biopsy	http://purl.obolibrary.org/obo/MAXO_0000374		
OBO:MAXO_0000375	biolink:NamedThing	biopsy of lip	Removal of tissue from the lip.		hp.json	lip biopsy	http://purl.obolibrary.org/obo/MAXO_0000375		
HP:0032841	biolink:PhenotypicFeature	Neonatal bilateral asymmetric epileptic spasm	Neonatal bilateral asymmetric epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs asymmetrically at both sides of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0032841		
HP:0032840	biolink:PhenotypicFeature	Neonatal bilateral symmetric epileptic spasm	Neonatal bilateral symmetric epileptic spasm is a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that occurs symmetrically at both sides of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0032840		
HP:0032847	biolink:PhenotypicFeature	Focal impaired awareness hemifacial clonic seizure	Focal seizure characterized at onset by clonic movements affecting half of the face with impairment of awareness in which awareness is impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032847		
HP:0032846	biolink:PhenotypicFeature	Focal motor seizure with negative myoclonus	A type of focal motor seizure characterized by a sudden interruption in normal tonic muscle activity lasting 500 ms or less, without evidence of preceding myoclonus as the initial semiological manifestation. The interruption in muscle tone is briefer than seen in a focal atonic seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032846		
HP:0032849	biolink:PhenotypicFeature	Aphasic status epilepticus	Aphasic status epilepticus is a type of focal non-convulsive status epilepticus without coma characterized by a cognitive (rather than motor) language deficit.		hp.json		http://purl.obolibrary.org/obo/HP_0032849		
HP:0032848	biolink:PhenotypicFeature	Focal aware cognitive seizure with neglect	A focal cognitive seizure with neglect characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032848		
HP:0032843	biolink:PhenotypicFeature	Focal-onset epileptic spasm	A type of epileptic spasm of focal onset.		hp.json	Focal onset epileptic spasm	http://purl.obolibrary.org/obo/HP_0032843		
HP:0032842	biolink:PhenotypicFeature	Generalized-onset epileptic spasm	A type of epileptic spasm of generalized onset.		hp.json	Generalised-onset epileptic spasm|Generalised onset epileptic spasm|Generalized onset epileptic spasm	http://purl.obolibrary.org/obo/HP_0032842		
HP:0032845	biolink:PhenotypicFeature	Focal aware epileptic spasm	A type of focal-onset epileptic spasm in which awareness is preserved throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032845		
HP:0032844	biolink:PhenotypicFeature	Focal impaired awareness epileptic spasm	A type of focal-onset epileptic spasm in which awareness is impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032844		
GO:0021578	biolink:BiologicalProcess	hindbrain maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.		hp.json		http://purl.obolibrary.org/obo/GO_0021578		
HP:0005297	biolink:PhenotypicFeature	Premature occlusive vascular stenosis	Peripheral arterial stenosis with onset before the age of 50 years.	UMLS:C1867457	hp.json		http://purl.obolibrary.org/obo/HP_0005297		
GO:0021579	biolink:BiologicalProcess	medulla oblongata morphogenesis	The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.		hp.json	myelencephalon morphogenesis|medulla morphogenesis	http://purl.obolibrary.org/obo/GO_0021579		
HP:0005298	biolink:PhenotypicFeature	obsolete Atrioventricular canal defect with right ventricle aorta and pulmonary atresia			hp.json		http://purl.obolibrary.org/obo/HP_0005298		
GO:0033554	biolink:BiologicalProcess	cellular response to stress	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).		hp.json		http://purl.obolibrary.org/obo/GO_0033554		gocheck_do_not_manually_annotate
OBO:MAXO_0000378	biolink:NamedThing	biopsy of lower urinary tract	Removal of tissue from the lower urinary tract.		hp.json	lower urinary tract biopsy	http://purl.obolibrary.org/obo/MAXO_0000378		
HP:0005299	biolink:PhenotypicFeature	obsolete Premature peripheral vascular disease			hp.json		http://purl.obolibrary.org/obo/HP_0005299		
OBO:MAXO_0000379	biolink:NamedThing	biopsy of lumbar region of vertebral column	Removal of tissue from the lumbar region of vertebral column.		hp.json	lumbar region of vertebral column biopsy	http://purl.obolibrary.org/obo/MAXO_0000379		
HP:0005293	biolink:PhenotypicFeature	Venous insufficiency		MSH:D014689|UMLS:C0042485|SNOMEDCT_US:20696009	hp.json	Poorly functioning veins	http://purl.obolibrary.org/obo/HP_0005293		
HP:0005294	biolink:PhenotypicFeature	Arterial dissection	A separation (dissection) of the layers of an artery.	SNOMEDCT_US:26845001|MSH:D000784|SNOMEDCT_US:233992003|SNOMEDCT_US:9406001|UMLS:C0002949|SNOMEDCT_US:710864009	hp.json		http://purl.obolibrary.org/obo/HP_0005294		
HP:0005295	biolink:PhenotypicFeature	Pseudocoarctation of the aorta	Pseudocoarctation is a congenital anomaly of kinking, or buckling, of the aorta without a pressure gradient across the lesion. It is characterized by elongation and kinking of the aorta at the level of the ligamentum arteriosum.	SNOMEDCT_US:70602002|UMLS:C0345088	hp.json		http://purl.obolibrary.org/obo/HP_0005295		
HP:0005296	biolink:PhenotypicFeature	obsolete Occlusive vascular disease			hp.json		http://purl.obolibrary.org/obo/HP_0005296		
GO:0021563	biolink:BiologicalProcess	glossopharyngeal nerve development	Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.		hp.json	cranial nerve 9 development|CN IX development|cranial nerve IX development	http://purl.obolibrary.org/obo/GO_0021563		
GO:0021564	biolink:BiologicalProcess	vagus nerve development	The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.		hp.json	cranial nerve X development|cranial nerve 10 development|CN X development	http://purl.obolibrary.org/obo/GO_0021564		
GO:0021565	biolink:BiologicalProcess	accessory nerve development	The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.		hp.json	cranial nerve 11 development|spinal accessory nerve development|CN XI development|cranial nerve XI development	http://purl.obolibrary.org/obo/GO_0021565		
GO:0021566	biolink:BiologicalProcess	hypoglossal nerve development	The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.		hp.json	cranial nerve 12 development|cranial nerve XII development|CN XII development	http://purl.obolibrary.org/obo/GO_0021566		
HP:0032850	biolink:PhenotypicFeature	Focal aware cognitive seizure with expressive dysphasia/aphasia	A focal cognitive seizure with expressive dysphasia / aphasia characterized by retained awareness throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032850		
HP:0032852	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with conduction dysphasia/aphasia	A focal cognitive seizure with conduction dysphasia / aphasia characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032852		
HP:0032851	biolink:PhenotypicFeature	Focal aware sensory seizure with visual features	A seizure characterized by elementary visual hallucinations such as flashing or flickering lights/colours, or other shapes, simple patterns, scotomata, or amaurosis.		hp.json		http://purl.obolibrary.org/obo/HP_0032851		
GO:0008585	biolink:BiologicalProcess	female gonad development	The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.		hp.json	ovary development|ovarian development	http://purl.obolibrary.org/obo/GO_0008585		
HP:0032858	biolink:PhenotypicFeature	Focal impaired awareness motor seizure with negative myoclonus	A focal motor seizure with negative myoclonus characterized by impairement of awareness at some point during the seizure.		hp.json	Focal motor impaired awareness seizure with negative myoclonus	http://purl.obolibrary.org/obo/HP_0032858		
HP:0032857	biolink:PhenotypicFeature	Focal aware motor seizure with negative myoclonus	A focal motor seizure with negative myoclonus characterized by retained awareness throughout the seizure.		hp.json	Focal motor aware seizure with negative myoclonus	http://purl.obolibrary.org/obo/HP_0032857		
HP:0032859	biolink:PhenotypicFeature	Focal impaired awareness motor seizure with paresis/paralysis	A focal motor seizure with paresis / paralysis characterized by impaired awareness at some point during the seizure.		hp.json	Focal motor impaired awareness seizure with paresis/paralysis	http://purl.obolibrary.org/obo/HP_0032859		
HP:0005268	biolink:PhenotypicFeature	Miscarriage	A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 22th week of pregnancy.	SNOMEDCT_US:17369002|UMLS:C0000786|MSH:D000022	hp.json	Spontaneous abortion|Early fetal demise	http://purl.obolibrary.org/obo/HP_0005268		
HP:0032854	biolink:PhenotypicFeature	Focal aware hemifacial clonic seizure	Focal seizure characterized at onset by clonic movements affecting half of the face with retained awareness throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032854		
HP:0032853	biolink:PhenotypicFeature	Focal impaired awareness sensory seizure with hot-cold sensations	A focal sensory seizure with hot-cold sensations in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032853		
HP:0032856	biolink:PhenotypicFeature	Focal aware bilateral motor seizure	A type of focal bilateral motor seizure during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032856		
HP:0032855	biolink:PhenotypicFeature	Photosensitive myoclonic-tonic-clonic seizure	Generalised myoclonic-tonic-clonic seizure provoked by flashing or flickering light.		hp.json	Photically induced myoclonic-tonic-clonic seizure	http://purl.obolibrary.org/obo/HP_0032855		
HP:0005264	biolink:PhenotypicFeature	Abnormality of the gallbladder	An abnormality of the gallbladder.	SNOMEDCT_US:253803008|SNOMEDCT_US:49714001|UMLS:C0266249	hp.json	Abnormality of the gallbladder|Anomaly of the gallbladder	http://purl.obolibrary.org/obo/HP_0005264		
HP:0005265	biolink:PhenotypicFeature	Abnormal jejunum morphology	An abnormality of the jejunum, i.e., of the middle section of the small intestine.	UMLS:C4025224	hp.json	Abnormality of the jejunum	http://purl.obolibrary.org/obo/HP_0005265		
HP:0005266	biolink:PhenotypicFeature	Intestinal polyp	A discrete abnormal tissue mass that protrudes into the lumen of the intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base.	SNOMEDCT_US:254588001|UMLS:C0021846|MSH:D007417	hp.json	Intestinal polyps	http://purl.obolibrary.org/obo/HP_0005266		
HP:0005267	biolink:PhenotypicFeature	Premature delivery because of cervical insufficiency or membrane fragility		UMLS:C1851808	hp.json		http://purl.obolibrary.org/obo/HP_0005267		
HP:0005261	biolink:PhenotypicFeature	Joint hemorrhage	Hemorrhage occurring within a joint.	MSH:D006395|SNOMEDCT_US:81808003|UMLS:C0018924	hp.json	Bleeding within a joint|Hemarthrosis|Joint haemorrhage|Hemarthroses|Spontaneous joint hemorrhage|Spontaneous joint haemorrhage	http://purl.obolibrary.org/obo/HP_0005261		
HP:0005262	biolink:PhenotypicFeature	Abnormality of the synovia		UMLS:C4025225	hp.json		http://purl.obolibrary.org/obo/HP_0005262		
HP:0005263	biolink:PhenotypicFeature	Gastritis	The presence of inflammation of the gastric mucous membrane.	MEDDRA:10017853|UMLS:C0017152|SNOMEDCT_US:4556007|MSH:D005756	hp.json	Stomach inflammation	http://purl.obolibrary.org/obo/HP_0005263		hposlim_core
OBO:MAXO_0000394	biolink:NamedThing	biopsy of perianal skin	Removal of tissue from the perianal skin.		hp.json	perianal skin biopsy	http://purl.obolibrary.org/obo/MAXO_0000394		
OBO:MAXO_0000395	biolink:NamedThing	biopsy of peritoneum	Removal of tissue from the peritoneum.		hp.json	peritoneum biopsy	http://purl.obolibrary.org/obo/MAXO_0000395		
HP:0005280	biolink:PhenotypicFeature	Depressed nasal bridge	Posterior positioning of the nasal root in relation to the overall facial profile for age.	UMLS:C4280495|UMLS:C3550546|UMLS:C1836542	hp.json	Flat bridge of nose|Depressed nasal bridge|Concave nasal bridge|Flattened nasal bridge|Flat, nasal bridge|Retruded bridge of nose|Low nasal bridge|Flat nasal root|Depressed nasal root/bridge|Depressed bridge of nose|Flat nasal bridge|Retruded nasal bridge|Concave bridge of nose|Depressed nasal root|Low nasal root	http://purl.obolibrary.org/obo/HP_0005280		hposlim_core
GO:0021550	biolink:BiologicalProcess	medulla oblongata development	The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.		hp.json	myelencephalon development|medulla development	http://purl.obolibrary.org/obo/GO_0021550		
OBO:MAXO_0000392	biolink:NamedThing	biopsy of pancreas	Removal of tissue from the pancreas.		hp.json	pancreas biopsy	http://purl.obolibrary.org/obo/MAXO_0000392		
HP:0005281	biolink:PhenotypicFeature	Hypoplastic nasal bridge		UMLS:C4280494|UMLS:C1865597	hp.json	Decreased size of bridge of nose|Hypotrophic nasal bridge|Hypoplastic bridge of nose|Small nasal bridge|Decreased size of nasal bridge|Hypotrophic bridge of nose|Small bridge of nose	http://purl.obolibrary.org/obo/HP_0005281		
OBO:MAXO_0000393	biolink:NamedThing	biopsy of penis	Removal of tissue from the penis.		hp.json	penis biopsy	http://purl.obolibrary.org/obo/MAXO_0000393		
GO:0021551	biolink:BiologicalProcess	central nervous system morphogenesis	The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.		hp.json		http://purl.obolibrary.org/obo/GO_0021551		
OBO:MAXO_0000398	biolink:NamedThing	biopsy of rectum	Removal of tissue from the rectum.		hp.json	rectum biopsy	http://purl.obolibrary.org/obo/MAXO_0000398		
OBO:MAXO_0000399	biolink:NamedThing	biopsy of retina	Removal of tissue from the retina.		hp.json	retina biopsy	http://purl.obolibrary.org/obo/MAXO_0000399		
OBO:MAXO_0000396	biolink:NamedThing	biopsy of pituitary gland	Removal of tissue from the pituitary gland.		hp.json	pituitary gland biopsy	http://purl.obolibrary.org/obo/MAXO_0000396		
GO:0021555	biolink:BiologicalProcess	midbrain-hindbrain boundary morphogenesis	The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.		hp.json	MHB morphogenesis|isthmus morphogenesis	http://purl.obolibrary.org/obo/GO_0021555		
OBO:MAXO_0000397	biolink:NamedThing	biopsy of pleura	Removal of tissue from the pleura.		hp.json	pleura biopsy	http://purl.obolibrary.org/obo/MAXO_0000397		
HP:0032861	biolink:PhenotypicFeature	Focal non-convulsive status epilepticus with impairment of consciousness	Focal non-convulsive status epilepticus with impairment of consciousness is a type of focal non-convulsive status epilepticus in which awareness is impaired.		hp.json	Focal non-convulsive status epilepticus with impairment of awareness	http://purl.obolibrary.org/obo/HP_0032861		
HP:0032860	biolink:PhenotypicFeature	Generalized non-convulsive status epilepticus without coma	Generalized non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically generalized. It is a prolonged absence seizure.		hp.json	Petit mal status epilepticus|Generalised non-convulsive status epilepticus without coma|Absence status epilepticus	http://purl.obolibrary.org/obo/HP_0032860		
HP:0030200	biolink:PhenotypicFeature	Fatiguable weakness of proximal limb muscles	A type of weakness of a skeletal muscle of proximal part of a limb that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.	UMLS:C4022583	hp.json		http://purl.obolibrary.org/obo/HP_0030200		
HP:0032863	biolink:PhenotypicFeature	Typical absence status epilepticus	Typical absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged typical absence seizure.		hp.json	Simple absence status epilepticus	http://purl.obolibrary.org/obo/HP_0032863		
HP:0030201	biolink:PhenotypicFeature	Response to drugs acting on neuromuscular transmission	Specific drugs interfere selectively with the different cellular mechanisms involved in neuromuscular transmission (synthesis, storage, release, action and inactivation of transmitter). The response of a patient to a specific drug can therefore be useful information for the differential diagnosis.	UMLS:C4022582	hp.json		http://purl.obolibrary.org/obo/HP_0030201		
HP:0032862	biolink:PhenotypicFeature	Status epilepticus with ictal paresis	A type of focal motor status epilepticus characterized by prolonged ictal paresis or inhibitory motor seizures.		hp.json	Focal inhibitory status epilepticus	http://purl.obolibrary.org/obo/HP_0032862		
OBO:MAXO_0000390	biolink:NamedThing	biopsy of neck	Removal of tissue from the neck.		hp.json	neck biopsy	http://purl.obolibrary.org/obo/MAXO_0000390		
OBO:MAXO_0000391	biolink:NamedThing	biopsy of ovary	Removal of tissue from the ovary.		hp.json	ovary biopsy	http://purl.obolibrary.org/obo/MAXO_0000391		
GO:0008594	biolink:BiologicalProcess	photoreceptor cell morphogenesis	The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.		hp.json	photoreceptor development	http://purl.obolibrary.org/obo/GO_0008594		
HP:0030206	biolink:PhenotypicFeature	EMG: incremental response of compound muscle action potential to repetitive nerve stimulation	A compound muscle action potential (CMAP) is a type of electromyography (EMG). CMAP refers to a group of almost simultaneous action potentials from several muscle fibers in the same area evoked by stimulation of the supplying motor nerve and are recorded as one multipeaked summated action potential. This abnormality refers to an abnormal increase in the amplitude during the course of the investigation.	UMLS:C4022579	hp.json		http://purl.obolibrary.org/obo/HP_0030206		
HP:0032869	biolink:PhenotypicFeature	Focal non-convulsive status epilepticus without impairment of consciousness	Focal non-convulsive status epilepticus without impairment of consciousness is a type of focal non-convulsive status epilepticus in which awareness remains intact.		hp.json	Focal non-convulsive status epilepticus without impairment of awareness|Aura continua|Focal non-convulsive status epilepticus with retained awareness	http://purl.obolibrary.org/obo/HP_0032869		
HP:0030207	biolink:PhenotypicFeature	Paradoxical respiration	Breathing movements in which the chest wall moves in on inspiration and out on expiration, in reverse of the normal movements. It may be seen in children with respiratory distress of any cause, which leads to indrawing of the intercostal spaces during inspiration. Patients with chronic airways obstruction also show indrawing of the lower ribs during inspiration, due to the distorted action of a depressed and flattened diaphragm. Crush injuries of the chest, with fractured ribs and sternum, can lead to a severe degree of paradoxical breathing.	SNOMEDCT_US:12025005|SNOMEDCT_US:78011002|MSH:D005409|UMLS:C0016196|UMLS:C0231852	hp.json	Flail chest|Paradoxical breathing	http://purl.obolibrary.org/obo/HP_0030207		
HP:0032868	biolink:PhenotypicFeature	Super-refractory status epilepticus	Super-refractory status epilepticus is defined as refractory status epilepticus continuing for 24 h or more following initiation of anesthetic medications, including cases in which seizure control is attained after induction of anesthetic drugs but recurs on weaning the patient off the anesthetic agent.		hp.json		http://purl.obolibrary.org/obo/HP_0032868		
HP:0030208	biolink:PhenotypicFeature	Anti-acetylcholine receptor antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ganglioside-monosialic acid (GM1), which is a type of glycosphingolipid with one sialic acid. GM1 is located on the outer layer of the plasma membrane, and plays a vital role in neurogenesis, nerve development, differentiation and repair after injury.	UMLS:C4022578	hp.json	Acetylcholine receptor antibody positivity|Anti-AChR antibody positivity	http://purl.obolibrary.org/obo/HP_0030208		
HP:0030209	biolink:PhenotypicFeature	Calcium channel antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against voltage-gated calcium channels.	UMLS:C4022577	hp.json	Ca channel antibody positivity|Ca2+ channel antibody positivity	http://purl.obolibrary.org/obo/HP_0030209		
HP:0030202	biolink:PhenotypicFeature	Favorable response of weakness to acetylcholine esterase inhibitors	Improvement of muscle strength in response to administration of an acetylcholine esterase inhibitor.	UMLS:C4022581	hp.json	Favourable response of weakness to acetylcholine esterase inhibitors	http://purl.obolibrary.org/obo/HP_0030202		
HP:0032865	biolink:PhenotypicFeature	Myoclonic absence status epilepticus	Myoclonic absence status epilepticus is a type of generalized non-convulsive status epilepticus without coma that is semiologically a prolonged myoclonic absence seizure. Myoclonic absence status epilepticus consists of proximal, predominantly upper extremity myoclonic jerks corresponding with 3 Hz spike-wave discharges in the EEG.		hp.json		http://purl.obolibrary.org/obo/HP_0032865		
HP:0030203	biolink:PhenotypicFeature	Unfavorable response of muscle weakness to acetylcholine esterase inhibitors	Lack of improvement of muscle strength in response to administration of an acetylcholine esterase inhibitor.	UMLS:C4022580	hp.json	Unfavourable response of muscle weakness to acetylcholine esterase inhibitors	http://purl.obolibrary.org/obo/HP_0030203		
HP:0032864	biolink:PhenotypicFeature	Focal aware sensory seizure with auditory features	A type of focal sensory seizure with auditory features during which awareness is retained throughout the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032864		
MPATH:496	biolink:NamedThing	Non-Lymphoid leukaemias	Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition.	URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2	hp.json		http://purl.obolibrary.org/obo/MPATH_496		
HP:0032867	biolink:PhenotypicFeature	Refractory status epilepticus	Refractory status epilepticus is defined as status epilepticus continuing despite two appropriately selected and dosed antiepileptic drugs, including a benzodiazepine.		hp.json		http://purl.obolibrary.org/obo/HP_0032867		
HP:0030205	biolink:PhenotypicFeature	Increased jitter at single fiber EMG	The variation in the time interval between the two action potentials of the same motor unit is called jitter. This term therefore applies to increased variability in the interval between successive action potentials of the same motor unit, which is measured by electromyography (EMG).	UMLS:C4021045	hp.json	Increased jitter at single fibre electromyography|Increased jitter at single fibre EMG	http://purl.obolibrary.org/obo/HP_0030205		
HP:0032866	biolink:PhenotypicFeature	Oculoclonic status epilepticus	A type of focal motor status epilepticus characterized by repetitive and rapid saccades, in association with epileptic discharges.		hp.json		http://purl.obolibrary.org/obo/HP_0032866		
GO:0021556	biolink:BiologicalProcess	central nervous system formation	The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.		hp.json		http://purl.obolibrary.org/obo/GO_0021556		
HP:0005275	biolink:PhenotypicFeature	Cartilaginous ossification of nose		UMLS:C1855616	hp.json	Cartilaginous nasal ossification	http://purl.obolibrary.org/obo/HP_0005275		
HP:0005278	biolink:PhenotypicFeature	Hypoplastic nasal tip		UMLS:C1844731|UMLS:C4280497|UMLS:C4280496	hp.json	Deficient nasal tip|Decreased size of nasal tip|Aplasia of nasal tip|Small tip of nose|Small nasal tip|Underdevelopment of tip of nose|Hypoplasia of tip of nose|Underdevelopment of nasal tip|Hypotrophic tip of nose|Hypotrophic nasal tip|Decreased size of tip of nose	http://purl.obolibrary.org/obo/HP_0005278		
GO:0021559	biolink:BiologicalProcess	trigeminal nerve development	The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.		hp.json	CN V development|cranial nerve V development|cranial nerve 5 development	http://purl.obolibrary.org/obo/GO_0021559		
HP:0005272	biolink:PhenotypicFeature	Prominent nasolabial fold	Exaggerated bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion, or commissure).	UMLS:C1866487	hp.json	Prominent smile lines|Prominent nasolabial groove|Deep laugh lines|Deep nasolabial fold|Prominent laugh lines|Deep nasolabial crease|Deep smile lines|Nasolabial crease, prominent|Deep nasolabial groove	http://purl.obolibrary.org/obo/HP_0005272		hposlim_core
HP:0005273	biolink:PhenotypicFeature	Absent nasal septal cartilage	Lack of the cartilage of the nasal septum.	UMLS:C4021638|UMLS:C4280501	hp.json	Ageneis of nasal septal cartilage|Absent nasal septum|Failure of development of nasal septal cartilage|Absent nasal septal cartilage	http://purl.obolibrary.org/obo/HP_0005273		hposlim_core
CHEBI:58389	biolink:ChemicalSubstance	trimethylammonium	An ammonium ion that is the conjugate acid of trimethylamine, obtained via protonation of the nitrogen; major species at pH 7.3.	Reaxys:16709444|MetaCyc:TRIMETHYLAMINE	hp.json	trimethylamine|N,N-dimethylmethanaminium|trimethylammonium cation|trimethylazanium|trimethylazanium cation	http://purl.obolibrary.org/obo/CHEBI_58389		3_STAR
HP:0005274	biolink:PhenotypicFeature	Prominent nasal tip		UMLS:C4280499|UMLS:C4280498|UMLS:C1856118|UMLS:C4280500	hp.json	Bulbous tip of nose|Hypertrophy of tip of nose|Hypertrophy of nasal tip|Prominent tip of nose|Prominent nasal tip|Hyperplasia of tip of nose|Hyperplasia of nasal tip|Pronounced tip of nose|Large tip of nose|Large nasal tip|Pronounced nasal tip	http://purl.obolibrary.org/obo/HP_0005274		
CHEBI:36902	biolink:ChemicalSubstance	chalcogen hydride			hp.json	chalcogen hydrides|chalcogen hydride	http://purl.obolibrary.org/obo/CHEBI_36902		3_STAR
HP:0007829	biolink:PhenotypicFeature	obsolete Diffuse retinal cone degeneration			hp.json		http://purl.obolibrary.org/obo/HP_0007829		
HP:0007825	biolink:PhenotypicFeature	obsolete Cataracts develop in second or third decade			hp.json		http://purl.obolibrary.org/obo/HP_0007825		
HP:0007824	biolink:PhenotypicFeature	Total ophthalmoplegia	Paralysis of both the extrinsic and intrinsic ocular muscles.	UMLS:C0155338|SNOMEDCT_US:78097002	hp.json	Total internal and external ophthalmoplegia|Complete ophthalmoplegia|Global paralysis of gaze	http://purl.obolibrary.org/obo/HP_0007824		
HP:0007827	biolink:PhenotypicFeature	Nodular corneal dystrophy		UMLS:C4024792	hp.json		http://purl.obolibrary.org/obo/HP_0007827		
HP:0007820	biolink:PhenotypicFeature	Lacrimal punctal atresia	Congenital absence or closure of the opening of the lacrimal punctum.	UMLS:C1863201	hp.json	Atretic lacrimal puncta|Atretic lacrimal punctum	http://purl.obolibrary.org/obo/HP_0007820		
HP:0007822	biolink:PhenotypicFeature	Central retinal exudate		UMLS:C4024793	hp.json		http://purl.obolibrary.org/obo/HP_0007822		
UBERON:0039377	biolink:AnatomicalEntity	urethral vein	A vein that drains the urethra.	FMA:21270	hp.json		http://purl.obolibrary.org/obo/UBERON_0039377		
CHEBI:36915	biolink:ChemicalSubstance	inorganic cation			hp.json	inorganic cations	http://purl.obolibrary.org/obo/CHEBI_36915		3_STAR
CHEBI:36916	biolink:ChemicalSubstance	cation	A monoatomic or polyatomic species having one or more elementary charges of the proton.	KEGG:C01373	hp.json	cation|cation|Kationen|cations|cationes|Cation|Kation	http://purl.obolibrary.org/obo/CHEBI_36916		3_STAR
CHEBI:36914	biolink:ChemicalSubstance	inorganic ion			hp.json	inorganic ions	http://purl.obolibrary.org/obo/CHEBI_36914		3_STAR
HP:0032803	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with dysgraphia/agraphia	A focal cognitive seizure with dysgraphia / agraphia characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032803		
HP:0007836	biolink:PhenotypicFeature	Mosaic corneal dystrophy		UMLS:C4024786	hp.json		http://purl.obolibrary.org/obo/HP_0007836		
HP:0032802	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with dyscalculia/acalculia	A focal cognitive seizure with dyscalculia / acalculia characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032802		
HP:0007835	biolink:PhenotypicFeature	S-shaped palpebral fissures		UMLS:C4024787	hp.json	S-shaped opening between the eyelids|S-shaped eyes	http://purl.obolibrary.org/obo/HP_0007835		
HP:0032805	biolink:PhenotypicFeature	Focal impaired awareness sensory seizure with vestibular features	A focal sensory seizure with vestibular features in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032805		
HP:0007838	biolink:PhenotypicFeature	Progressive ptosis	A progressive form of ptosis.	UMLS:C1834015	hp.json	Progressive drooping of upper eyelid	http://purl.obolibrary.org/obo/HP_0007838		
HP:0032804	biolink:PhenotypicFeature	Focal impaired awareness sensory seizure with olfactory features	A focal sensory seizure with olfaction in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032804		
HP:0007832	biolink:PhenotypicFeature	Pigmentation of the sclera		UMLS:C1859882	hp.json	Pigmentation of the outer white part of the eyeball	http://purl.obolibrary.org/obo/HP_0007832		
MPATH:474	biolink:NamedThing	ectasia	Dilation of a tubular structure.		hp.json		http://purl.obolibrary.org/obo/MPATH_474		
HP:0007831	biolink:PhenotypicFeature	Nonprogressive restrictive external ophthalmoplegia	Nonprogressive restriction of movement of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position. Residual eye movements are significantly limited.	UMLS:C4024789	hp.json		http://purl.obolibrary.org/obo/HP_0007831		
HP:0007834	biolink:PhenotypicFeature	Progressive cataract	A kind of cataract that progresses with age.	UMLS:C4021566	hp.json	Cataract, progressive	http://purl.obolibrary.org/obo/HP_0007834		
HP:0032801	biolink:PhenotypicFeature	Focal impaired awareness cognitive seizure with memory impairment	A focal cognitive seizure with memory impairment characterized by impairment of awareness at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032801		
HP:0032800	biolink:PhenotypicFeature	Focal aware sensory seizure with vestibular features	A seizure characterized by symptoms of dizziness, spinning, vertigo or sense of rotation.		hp.json		http://purl.obolibrary.org/obo/HP_0032800		
HP:0007833	biolink:PhenotypicFeature	Anterior chamber synechiae		UMLS:C4024788	hp.json		http://purl.obolibrary.org/obo/HP_0007833		
MPATH:476	biolink:NamedThing	telangiectasia	A lesion formed by a dilated capillary or terminal artery.		hp.json		http://purl.obolibrary.org/obo/MPATH_476		
HP:0007830	biolink:PhenotypicFeature	Adult-onset night blindness	Inability to see well at night or in poor light with onset in adulthood.	UMLS:C4024790	hp.json	Adult-onset night blindness	http://purl.obolibrary.org/obo/HP_0007830		
HP:0032807	biolink:PhenotypicFeature	Neonatal seizure	A seizure occurring within the neonatal period (28 days beyond the full term date).		hp.json		http://purl.obolibrary.org/obo/HP_0032807		
HP:0032806	biolink:PhenotypicFeature	Focal impaired awareness sensory seizure with visual features	A focal sensory seizure with visual features in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032806		
HP:0032809	biolink:PhenotypicFeature	Neonatal electro-clinical seizure	Neonatal electro-clinical seizure is an electrographic event occurring in neonatal period and coupled with a clinical manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032809		
HP:0032808	biolink:PhenotypicFeature	Neonatal seizure with electrographic correlate	Neonatal seizure is a seizure type that occurs in neonatal period and is characterized by an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end. This event can be associated or not with a clinical manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032808		
OBO:MAXO_0000483	biolink:NamedThing	medical professional evaluation	A procedure where a healthcare provider, who was not previously involved in a patient's treatment, reviews a patient's medical history, examines the patient, and makes recommendations as to care and treatment.		hp.json	medical professional examination|medical professional consultation	http://purl.obolibrary.org/obo/MAXO_0000483		
OBO:MAXO_0000487	biolink:NamedThing	clinical assessment	A measurement performed in a clinical setting using clinician's observations and instrument data to inform patient care and research.	CMO:0000000|PMID:2647562	hp.json	clinical measurement	http://purl.obolibrary.org/obo/MAXO_0000487		
HP:0007807	biolink:PhenotypicFeature	Optic nerve compression		UMLS:C0271344|SNOMEDCT_US:72983001	hp.json		http://purl.obolibrary.org/obo/HP_0007807		
HP:0007809	biolink:PhenotypicFeature	Punctate corneal dystrophy		UMLS:C4024796	hp.json		http://purl.obolibrary.org/obo/HP_0007809		
HP:0007808	biolink:PhenotypicFeature	obsolete Bilateral retinal coloboma			hp.json		http://purl.obolibrary.org/obo/HP_0007808		
UBERON:0003395	biolink:AnatomicalEntity	mesentery of rectum	A mesentery that is part of a rectum [Automatically generated definition].	EMAPA:18664	hp.json	rectum mesentery	http://purl.obolibrary.org/obo/UBERON_0003395		
HP:0007803	biolink:PhenotypicFeature	Monochromacy	Complete color blindness, a complete inability to distinguish colors. Affected persons cannot perceive colors, but only shades of gray.	UMLS:C0152200|UMLS:C1857618|MSH:C536128|SNOMEDCT_US:56852002|MSH:D003117	hp.json	Complete achromatopsia|Total colorblindness	http://purl.obolibrary.org/obo/HP_0007803		
HP:0032814	biolink:PhenotypicFeature	Neonatal electro-clinical clonic seizure	Neonatal electro-clinical clonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is a regularly repeating jerking involving the same muscle groups; it can be symmetric or asymmetric.		hp.json	Neonatal electroclinical clonic seizure	http://purl.obolibrary.org/obo/HP_0032814		
UBERON:0003396	biolink:AnatomicalEntity	mesentery of colon	A mesentery that is part of a colon [Automatically generated definition].	FMA:14645|EMAPA:18942	hp.json	mesentery of large intestine|colon mesentery|mesocolon|large bowel mesentery|mesentery of large bowel|large intestinal mesentery	http://purl.obolibrary.org/obo/UBERON_0003396		
HP:0032813	biolink:PhenotypicFeature	Neonatal electro-clinical motor seizure	Neonatal electro-clinical motor seizure is a type of neonatal electro-clinical seizure with predominant motor features.		hp.json		http://purl.obolibrary.org/obo/HP_0032813		
HP:0007802	biolink:PhenotypicFeature	Granular corneal dystrophy	The presence of central, fine, whitish granular lesions in the stroma of the cornea. This type of corneal dystrophy is usually asymptomatic and begins in childhood and shows a slow progression. Later in the course, the corneal epithelium and Bowman's layer may be affected. Histologically, the cornea shows a uniform deposition of hyaline material.	UMLS:C0018179|MSH:D003317|SNOMEDCT_US:45283008	hp.json		http://purl.obolibrary.org/obo/HP_0007802		
HP:0032816	biolink:PhenotypicFeature	Neonatal multifocal myoclonic seizure	Neonatal multifocal myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) wich occurs at multiple sites.		hp.json		http://purl.obolibrary.org/obo/HP_0032816		
UBERON:0003393	biolink:AnatomicalEntity	mesentery of urinary system	A mesentery that is part of a urinary system [Automatically generated definition].	MA:0003233|EMAPA:17367	hp.json	excretory system mesentery|renal system mesentery|urinary system mesentery|systema urinaria mesentery|mesentery of excretory system|mesentery of renal system|mesentery of systema urinaria	http://purl.obolibrary.org/obo/UBERON_0003393		
UBERON:0003394	biolink:AnatomicalEntity	mesentery of hindgut	A mesentery that is part of a hindgut [Automatically generated definition].	EMAPA:16718	hp.json	hindgut mesentery	http://purl.obolibrary.org/obo/UBERON_0003394		
HP:0032815	biolink:PhenotypicFeature	Neonatal electro-clinical myoclonic seizure	Neonatal electro-clinical myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal).		hp.json	Neonatal electroclinical myoclonic seizure	http://purl.obolibrary.org/obo/HP_0032815		
HP:0032810	biolink:PhenotypicFeature	Focal sensory seizure with cephalic sensation	A seizure characterized by a sensation in the head such as light-headedness or headache as its first clinical manifestation.		hp.json	Partial seizure with cephalic sensation|Cephalic aura|Focal seizure with cephalic sensation	http://purl.obolibrary.org/obo/HP_0032810		
HP:0032812	biolink:PhenotypicFeature	Neonatal electro-clinical non-motor seizure			hp.json		http://purl.obolibrary.org/obo/HP_0032812		
HP:0007801	biolink:PhenotypicFeature	obsolete Fishnet retinal pigmentation			hp.json		http://purl.obolibrary.org/obo/HP_0007801		
HP:0007800	biolink:PhenotypicFeature	Increased axial length of the globe	Abnormal largeness of the eye with an axial length > 2.5 standard deviations from population mean.	UMLS:C1835117	hp.json	Increased axial globe length|Globe elongated|Increased front to back length of eyeball	http://purl.obolibrary.org/obo/HP_0007800		
UBERON:0003390	biolink:AnatomicalEntity	mesothelium of pleural cavity	A mesothelium that is part of a pleural cavity [Automatically generated definition].	EHDAA2:0001476|BTO:0003155|EMAPA:16775|FMA:18148	hp.json	mesothelium of pleura|pleura|pleural cavity mesothelium|pleural cavity meso-epithelium|pleural mesothelium|meso-epithelium of pleural cavity	http://purl.obolibrary.org/obo/UBERON_0003390		
HP:0032811	biolink:PhenotypicFeature	Neonatal electrographic only seizure	Neonatal electrographic only seizure is an electrographic event with sudden, repetitive, evolving stereotyped waveforms with a beginning and an end, which is not associated with a clinical manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0032811		
OBO:MAXO_0000488	biolink:NamedThing	body temperature measurement	An assessment of body temperature.	CMO:0000015|NCBIBook:NBK331	hp.json		http://purl.obolibrary.org/obo/MAXO_0000488		
OBO:MAXO_0000489	biolink:NamedThing	vital signs measurement	The act of assessing an individual's current temperature, heart rate, respiratory rate, pulse oxygenation, and blood pressure.	NCIT:C49672	hp.json	vital signs assessment|VSTEST	http://purl.obolibrary.org/obo/MAXO_0000489		
HP:0032818	biolink:PhenotypicFeature	Neonatal focal clonic seizure	Neonatal focal clonic seizure is a type of neonatal electro-clinical clonic seizure where the predominant motor feature is unilateral regularly repeating jerking involving the same muscle groups.		hp.json		http://purl.obolibrary.org/obo/HP_0032818		
HP:0032817	biolink:PhenotypicFeature	Neonatal focal myoclonic seizure	Neonatal focal myoclonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is sudden, brief (<100 msec) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal) which occurs focally.		hp.json		http://purl.obolibrary.org/obo/HP_0032817		
UBERON:0003397	biolink:AnatomicalEntity	mesentery of duodenum	A mesentery that is part of a duodenum [Automatically generated definition].	EMAPA:19081	hp.json	duodenum mesentery	http://purl.obolibrary.org/obo/UBERON_0003397		
UBERON:0003398	biolink:AnatomicalEntity	mesentery of jejunum	A mesentery that is part of a jejunum [Automatically generated definition].	FMA:14651|EMAPA:18670	hp.json	mesojejunum|jejunal mesentery|jejunum mesentery	http://purl.obolibrary.org/obo/UBERON_0003398		
HP:0032819	biolink:PhenotypicFeature	Neonatal bilateral clonic seizure	Neonatal bilateral clonic seizure is a type of neonatal electro-clinical clonic seizure where the clonic jerking is bilateral.		hp.json		http://purl.obolibrary.org/obo/HP_0032819		
HP:0007818	biolink:PhenotypicFeature	Central heterochromia	The presence of distinct colors in the central (pupillary) zone of the iris than in the mid-peripheral (ciliary) zone.	UMLS:C4021567	hp.json	Ring iris heterochromia	http://purl.obolibrary.org/obo/HP_0007818		
HP:0007817	biolink:PhenotypicFeature	Horizontal supranuclear gaze palsy	A supranuclear gaze palsy is an inability to look in a horizontal direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal.	UMLS:C4024794	hp.json		http://purl.obolibrary.org/obo/HP_0007817		
HP:0007819	biolink:PhenotypicFeature	Presenile cataracts	Presenile cataract is a kind of cataract that occurs in early adulthood, that is, at an age that is younger than usual.	UMLS:C0154971|SNOMEDCT_US:441622000	hp.json	Presenile cataract	http://purl.obolibrary.org/obo/HP_0007819		
UBERON:0003384	biolink:AnatomicalEntity	skeletal muscle tissue of pharynx	A portion of skeletal muscle tissue that is part of a pharynx [Automatically generated definition].	EMAPA:18963	hp.json	skeletal muscle tissue of pharynx|pharynx skeletal muscle tissue|pharynx skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0003384		
HP:0007814	biolink:PhenotypicFeature	Retinal pigment epithelial mottling	Mottling (spots or blotches with different shades) of the retinal pigment epithelium, i.e., localized or generalized fundal pigment granularity associated with processes at the level of the retinal pigment epithelium.	UMLS:C1857644	hp.json	RPE mottling|Focal hypopigmentation of the retinal pigment epithelium|Salt and pepper retinal pigmentation|Retinal pigment epithelium irregularity|Salt and pepper retinopathy|RPE irregularity	http://purl.obolibrary.org/obo/HP_0007814		
HP:0032825	biolink:PhenotypicFeature	Neonatal electro-clinical sequential seizure	Neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic signs, often changing lateralization within or between seizures.		hp.json	Neonatal electroclinical sequential seizure	http://purl.obolibrary.org/obo/HP_0032825		
HP:0032824	biolink:PhenotypicFeature	Neonatal focal tonic seizure	Neonatal focal tonic seizure is a type of neonatal electro-clinical tonic seizure with a focal sustained increase in muscle tone, lasting a few seconds to minutes.		hp.json		http://purl.obolibrary.org/obo/HP_0032824		
HP:0007813	biolink:PhenotypicFeature	Nongranulomatous uveitis	A form of uveitis that is not associated with the formation of granulomas.	UMLS:C4024795	hp.json		http://purl.obolibrary.org/obo/HP_0007813		
HP:0032827	biolink:PhenotypicFeature	Multifocal neonatal sequential seizure	Multifocal neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic multifocal signs.		hp.json		http://purl.obolibrary.org/obo/HP_0032827		
UBERON:0003382	biolink:AnatomicalEntity	cardiac muscle of left ventricle	A portion of cardiac muscle tissue that is part of a left ventricle [Automatically generated definition].	FMA:83453|EMAPA:17339|VHOG:0001234	hp.json	left ventricular cardiac muscle tissue|cardiac muscle tissue of left ventricle|left ventricle cardiac muscle	http://purl.obolibrary.org/obo/UBERON_0003382		
HP:0032826	biolink:PhenotypicFeature	Focal neonatal sequential seizure	Focal neonatal electro-clinical sequential motor seizure is a type of neonatal electro-clinical seizure where the predominant feature cannot be detected because of seizures presenting with a variety of clinical and electrographic focal signs, often changing lateralization within or between seizures.		hp.json		http://purl.obolibrary.org/obo/HP_0032826		
HP:0007815	biolink:PhenotypicFeature	Abnormal distribution of retinal arterioles and venules		UMLS:C3277463	hp.json		http://purl.obolibrary.org/obo/HP_0007815		
UBERON:0003383	biolink:AnatomicalEntity	cardiac muscle tissue of interventricular septum	A portion of cardiac muscle tissue that is part of an interventricular septum [Automatically generated definition].	VHOG:0000999|EHDAA2:0004158|FMA:84084|EMAPA:17335	hp.json	cardiac muscle of interventricular septum|interventricular septum myocardium|interventricular septum heart muscle|interventricular septum muscle|interventricular septum muscle|cardiac muscle tissue of interventricular septum|interventricular septum cardiac muscle	http://purl.obolibrary.org/obo/UBERON_0003383		
UBERON:0003380	biolink:AnatomicalEntity	cardiac muscle of left atrium	A portion of cardiac muscle tissue that is part of a left atrium [Automatically generated definition].	EMAPA:17320|FMA:7285|VHOG:0001225|EHDAA2:0004154|SCTID:189936008	hp.json	left atrium heart muscle|textus muscularis of myocardium of left atrium|textus muscularis of myocardium of cardiac left atrium|cardiac muscle of cardiac left atrium|cardiac left atrium cardiac muscle tissue|myocardium of left atrium|cardiac muscle of heart left atrium|textus muscularis of myocardium of heart left atrium|textus muscularis of myocardium of left atrium of heart|textus muscularis of myocardium of left cardiac atrium|cardiac muscle of left atrium of heart|cardiac left atrium cardiac muscle|left atrium myocardium	http://purl.obolibrary.org/obo/UBERON_0003380		
HP:0032821	biolink:PhenotypicFeature	Neonatal electro-clinical tonic seizure	Neonatal electro-clinical tonic seizure is a type of neonatal electro-clinical motor seizure where the predominant motor feature is a sustained increase in muscle tone, usually focal, that can be unilateral or bilateral, and lasting a few seconds to minutes.		hp.json		http://purl.obolibrary.org/obo/HP_0032821		
HP:0007810	biolink:PhenotypicFeature	obsolete Progressive bifocal chorioretinal atrophy			hp.json		http://purl.obolibrary.org/obo/HP_0007810		
HP:0032820	biolink:PhenotypicFeature	Neonatal multifocal clonic seizure	Neonatal focal clonic seizure is a type of neonatal electro-clinical clonic seizure where the predominant motor feature is a regularly repeating jerking involving the same muscle groups, which occurs at multiple sites.		hp.json		http://purl.obolibrary.org/obo/HP_0032820		
UBERON:0003381	biolink:AnatomicalEntity	cardiac muscle of right ventricle	A portion of cardiac muscle tissue that is part of a right ventricle [Automatically generated definition].	EMAPA:17342|FMA:83452|VHOG:0001236	hp.json	right ventricle cardiac muscle|cardiac muscle tissue of right ventricle|right ventricular cardiac muscle tissue	http://purl.obolibrary.org/obo/UBERON_0003381		
HP:0007812	biolink:PhenotypicFeature	Herpetiform corneal ulceration	The presence of one or more dendritic corneal epithelial ulcers characterized by a treelike branching linear pattern with feathery edges and terminal bulbs. Herpetiform corneal ulcers can be identified by fluorescein staining.	UMLS:C4020911	hp.json	Dendritic corneal epithelial ulcer|Herpetiform corneal ulcers	http://purl.obolibrary.org/obo/HP_0007812		
HP:0032823	biolink:PhenotypicFeature	Neonatal electro-clinical seizure with behavior arrest	Neonatal electro-clinical non-motor seizure with behavior arrest is a type of neonatal electro-clinical seizure characterized by an arrest of activities, freezing, immobilization, with or without apnea and/or other autonomic manifestations.		hp.json	Neonatal electroclinical seizure with behavioural arrest|Neonatal electro-clinical seizure with behaviour arrest	http://purl.obolibrary.org/obo/HP_0032823		
HP:0007811	biolink:PhenotypicFeature	Horizontal pendular nystagmus	Nystagmus consisting of horizontal to-and-fro eye movements of equal velocity.	UMLS:C1866180	hp.json		http://purl.obolibrary.org/obo/HP_0007811		
HP:0032822	biolink:PhenotypicFeature	Neonatal electro-clinical autonomic seizure	Neonatal electro-clinical non-motor autonomic seizure is a type of neonatal electro-clinical seizure with predominant features of autonomic alterations, involving cardiovascular, pupillary, gastrointestinal, sudomotor, vasomotor, and thermoregulatory functions. May present as apnea.		hp.json		http://purl.obolibrary.org/obo/HP_0032822		
CHEBI:24913	biolink:ChemicalSubstance	isoprenoid	Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives.	PMID:19219049|LIPID_MAPS_class:LMPR01|PMID:12769708	hp.json	isoprenoids|isoprenoid|isoprenoids	http://purl.obolibrary.org/obo/CHEBI_24913		3_STAR
OBO:MAXO_0000478	biolink:NamedThing	orthopedic surgeon evaluation	Assessment by a surgeon who focuses on the preservation, investigation and restoration of the form and function of the extremities, spine and associated structures by medical, surgical and physical means. This specialist is involved with the care of patients whose musculoskeletal problems include congenital deformities, trauma, infections, tumors, metabolic disturbances of the musculoskeletal system, deformities, injuries and degenerative diseases of the spine, hands, feet, knee, hip, shoulder and elbow in children and adults. An orthopaedic surgeon is also concerned with primary and secondary muscular problems and the effects of central or peripheral nervous system lesions of the musculoskeletal system.		hp.json	referral to orthopedist|consultation with orthopedic surgeon|referral to orthopedic surgeon|orthopedic surgeon referral|orthopaedic consult|orthopedic consult|orthopedic surgeon consultation|orthopedist consultation	http://purl.obolibrary.org/obo/MAXO_0000478		
UBERON:0003388	biolink:AnatomicalEntity	mesothelium of pericardial cavity	A mesothelium that is part of a pericardium [Automatically generated definition].	RETIRED_EHDAA2:0001436	hp.json	pericardial cavity mesothelium|cavity of pericardial sac mesothelium|pericardial cavity meso-epithelium|cavity of pericardial sac meso-epithelium|meso-epithelium of pericardial cavity|meso-epithelium of cavity of pericardial sac|mesothelium of cavity of pericardial sac	http://purl.obolibrary.org/obo/UBERON_0003388		
HP:0032829	biolink:PhenotypicFeature	Neonatal electro-clinical motor seizure with automatism	Neonatal electro-clinical motor seizure with automatism is a type of neonatal electro-clinical seizure where the electrographic event is correlated with a coordinated motor activity, typically oral, usually with impaired awarness, and in association with other features.		hp.json	Neonatal electroclinical motor seizure with automatism	http://purl.obolibrary.org/obo/HP_0032829		
HP:0032828	biolink:PhenotypicFeature	Neonatal bilateral symmetric tonic seizure	Neonatal bilateral symmetric tonic seizure is a type of neonatal electro-clinical tonic seizure where the sustained increase in muscle tone, lasting a few seconds to minutes, occurs at both sides of the body symmetrically.		hp.json		http://purl.obolibrary.org/obo/HP_0032828		
UBERON:0003389	biolink:AnatomicalEntity	mesothelium of diaphragm	A mesothelium that is part of a diaphragm [Automatically generated definition].	EMAPA:18429	hp.json	meso-epithelium of diaphragm|thoracic diaphragm mesothelium|thoracic diaphragm meso-epithelium|diaphragm mesothelium|diaphragm meso-epithelium|mesothelium of thoracic diaphragm|meso-epithelium of thoracic diaphragm	http://purl.obolibrary.org/obo/UBERON_0003389		
UBERON:0003386	biolink:AnatomicalEntity	smooth muscle of eye	Any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi.	MA:0001268|EMAPA:18807	hp.json	ocular smooth muscle	http://purl.obolibrary.org/obo/UBERON_0003386		pheno_slim
UBERON:0003387	biolink:AnatomicalEntity	smooth muscle of trachea	A portion of smooth muscle tissue that is part of a trachea [Automatically generated definition].	MA:0001863|BTO:0001391|NCIT:C49306|UMLS:C1710458|EMAPA:19192|FMA:262010	hp.json	tracheal smooth muscle|trachea smooth muscle	http://purl.obolibrary.org/obo/UBERON_0003387		pheno_slim|human_reference_atlas
OBO:MAXO_0000420	biolink:NamedThing	biopsy of uterine cervix	Removal of tissue from the uterine cervix.		hp.json	uterine cervix biopsy	http://purl.obolibrary.org/obo/MAXO_0000420		
OBO:MAXO_0000421	biolink:NamedThing	biopsy of vagina	Removal of tissue from the vagina.		hp.json	vagina biopsy	http://purl.obolibrary.org/obo/MAXO_0000421		
HP:0005206	biolink:PhenotypicFeature	Pancreatic pseudocyst	Cyst-like space not lined by epithelium and contained within the pancreas. Pancreatic pseudocysts are often associated with pancreatitis.	UMLS:C0030299|SNOMEDCT_US:111374002|MSH:D010192	hp.json		http://purl.obolibrary.org/obo/HP_0005206		
HP:0007869	biolink:PhenotypicFeature	obsolete Peripheral retinopathy			hp.json		http://purl.obolibrary.org/obo/HP_0007869		
HP:0005207	biolink:PhenotypicFeature	Gastric hypertrophy	Hypertrophy of the stomach.	UMLS:C1834341|UMLS:C4280502	hp.json	Increased stomach size	http://purl.obolibrary.org/obo/HP_0005207		
HP:0007868	biolink:PhenotypicFeature	obsolete Age-related macular degeneration			hp.json		http://purl.obolibrary.org/obo/HP_0007868		
HP:0005208	biolink:PhenotypicFeature	Secretory diarrhea	Watery voluminous diarrhea resulting from an imbalance between ion and water secretion and absorption.	UMLS:C0267557|SNOMEDCT_US:15699003	hp.json	Secretory diarrhoea	http://purl.obolibrary.org/obo/HP_0005208		
HP:0005209	biolink:PhenotypicFeature	Intrahepatic bile duct cysts	The presence of cyst of the intrahepatic bile duct.	UMLS:C0400991|SNOMEDCT_US:235925007	hp.json		http://purl.obolibrary.org/obo/HP_0005209		
HP:0005202	biolink:PhenotypicFeature	Helicobacter pylori infection	A recurrent infection of the GI tract with helicobacter pylori, a gram-negative, microaerophilic bacterium usually found in the stomach.	UMLS:C0850666	hp.json		http://purl.obolibrary.org/obo/HP_0005202		
HP:0005203	biolink:PhenotypicFeature	Spontaneous esophageal perforation	The occurrence of the full-thickness tear (perforation) of the wall of the esophagus.	MSH:C536571|SNOMEDCT_US:19995004|UMLS:C0238115	hp.json	Spontaneous esophageal rupture|Boerhaave syndrome	http://purl.obolibrary.org/obo/HP_0005203		
HP:0007867	biolink:PhenotypicFeature	Restrictive partial external ophthalmoplegia	Fibrosis of only some of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position.	UMLS:C4024781	hp.json		http://purl.obolibrary.org/obo/HP_0007867		
HP:0007866	biolink:PhenotypicFeature	Retinal infarction		UMLS:C0281967	hp.json		http://purl.obolibrary.org/obo/HP_0007866		
OBO:MAXO_0000424	biolink:NamedThing	medical magnetic resonance imaging procedure	Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide amazingly clear and detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders.	NCIT:C16809	hp.json	MRI scan for therapeutics|nuclear magnetic resonance imaging for medical therapy|NMRI|therapeutic MRI	http://purl.obolibrary.org/obo/MAXO_0000424		
OBO:MAXO_0000425	biolink:NamedThing	MRI of the head	A medical examination performed using of magnetic resonance imaging to image the head.		hp.json	head magnetic resonance imaging|head MRI|Nuclear magnetic resonance imaging of the head	http://purl.obolibrary.org/obo/MAXO_0000425		
OBO:MAXO_0000422	biolink:NamedThing	biopsy of vermiform appendix	Removal of tissue from the vermiform appendix.		hp.json	vermiform appendix biopsy	http://purl.obolibrary.org/obo/MAXO_0000422		
HP:0005200	biolink:PhenotypicFeature	Retroperitoneal fibrosis		SNOMEDCT_US:49120005|UMLS:C0035357|MSH:D012185	hp.json		http://purl.obolibrary.org/obo/HP_0005200		
HP:0005201	biolink:PhenotypicFeature	Anomalous splenoportal venous system		UMLS:C4025236	hp.json		http://purl.obolibrary.org/obo/HP_0005201		
OBO:MAXO_0000423	biolink:NamedThing	biopsy of skin	Removal of tissue from the zone of skin.		hp.json	skin biopsy|zone of skin biopsy	http://purl.obolibrary.org/obo/MAXO_0000423		
HP:0007862	biolink:PhenotypicFeature	Retinal calcification	Deposition of calcium salts in the retina.	UMLS:C1867289	hp.json		http://purl.obolibrary.org/obo/HP_0007862		
OBO:MAXO_0000428	biolink:NamedThing	MRI of the chest	A medical examination performed using of magnetic resonance imaging to image the chest.		hp.json	chest magnetic resonance imaging|Nuclear magnetic resonance imaging of the chest|chest MRI	http://purl.obolibrary.org/obo/MAXO_0000428		
OBO:MAXO_0000426	biolink:NamedThing	MRI of the abdomen	A medical examination performed using of magnetic resonance imaging to image the abdomen.		hp.json	abdomen magnetic resonance imaging|abdomen MRI|Nuclear magnetic resonance imaging of the abdomen	http://purl.obolibrary.org/obo/MAXO_0000426		
OBO:MAXO_0000427	biolink:NamedThing	MRI of the brain	A medical examination performed using of magnetic resonance imaging to image the brain.		hp.json	brain MRI|Nuclear magnetic resonance imaging of the brain|brain magnetic resonance imaging	http://purl.obolibrary.org/obo/MAXO_0000427		
OBO:MAXO_0000410	biolink:NamedThing	biopsy of thymus	Removal of tissue from the thymus.		hp.json	thymus biopsy	http://purl.obolibrary.org/obo/MAXO_0000410		
HP:0005217	biolink:PhenotypicFeature	Duplication of internal organs		UMLS:C4025234	hp.json		http://purl.obolibrary.org/obo/HP_0005217		
HP:0005218	biolink:PhenotypicFeature	Anoperineal fistula	The presence of a fistula (abnormal tunnel) between the anal canal and the perineum.	UMLS:C1835798	hp.json	Perianal fistula	http://purl.obolibrary.org/obo/HP_0005218		
HP:0007879	biolink:PhenotypicFeature	Allergic conjunctivitis	Allergic Conjunctivitis is an allergic inflammation of the conjunctiva.	SNOMEDCT_US:473460002|MSH:D003233|SNOMEDCT_US:231854006|UMLS:C0009766	hp.json		http://purl.obolibrary.org/obo/HP_0007879		
OBO:MAXO_0000419	biolink:NamedThing	biopsy of urinary bladder	Removal of tissue from the urinary bladder.		hp.json	urinary bladder biopsy	http://purl.obolibrary.org/obo/MAXO_0000419		
HP:0005219	biolink:PhenotypicFeature	Absence of intrinsic factor	Absence of gastric intrinsic factor, which is normally produced by the parietal cells of the stomach, and is required for the absorption of vitamin B12.	UMLS:C4021641	hp.json	Intrinsic factor absent from gastric juice	http://purl.obolibrary.org/obo/HP_0005219		
HP:0005213	biolink:PhenotypicFeature	Pancreatic calcification	The presence of abnormal calcium deposition lesions in the pancreas.	UMLS:C1842406	hp.json	Pancreatic calcifications	http://purl.obolibrary.org/obo/HP_0005213		
HP:0007876	biolink:PhenotypicFeature	obsolete Juvenile cortical cataract			hp.json		http://purl.obolibrary.org/obo/HP_0007876		
UBERON:1000004	biolink:AnatomicalEntity	collection of hair on external ear	A collection of hairs that grows on the external ear.		hp.json	external ear hair	http://purl.obolibrary.org/obo/UBERON_1000004		phenotype_rcn
HP:0005214	biolink:PhenotypicFeature	Intestinal obstruction	Blockage or impairment of the normal flow of the contents of the intestine towards the anal canal.	UMLS:C0021843|SNOMEDCT_US:81060008|MSH:D007415	hp.json	Intestinal obstruction|Bowel obstruction|Intestinal blockage	http://purl.obolibrary.org/obo/HP_0005214		
HP:0007875	biolink:PhenotypicFeature	Congenital blindness	Blindness with onset at birth.	UMLS:C0005754|SNOMEDCT_US:95486002	hp.json	Blindness present at birth|Congenital amaurosis	http://purl.obolibrary.org/obo/HP_0007875		
HP:0005215	biolink:PhenotypicFeature	Frequent Giardia lamblia infestation	Increased susceptibility to Giardia lamblia infection of the intestine, as manifested by a medical history of multiple episodes of Giardia lamblia intestinal infection.	UMLS:C4025235	hp.json		http://purl.obolibrary.org/obo/HP_0005215		
HP:0005216	biolink:PhenotypicFeature	Impaired mastication	An abnormal reduction in the ability to masticate (chew), i.e., in the ability to crush and ground food in preparation for swallowing.	UMLS:C0239043|SNOMEDCT_US:162020001	hp.json	Chewing difficulties|Difficulty chewing|Chewing difficulty	http://purl.obolibrary.org/obo/HP_0005216		
OBO:MAXO_0000413	biolink:NamedThing	biopsy of tonsil	Removal of tissue from the tonsil.		hp.json	tonsil biopsy	http://purl.obolibrary.org/obo/MAXO_0000413		
HP:0007872	biolink:PhenotypicFeature	Choroidal hemangioma	The presence of multiple hemangiomas in the choroid. These are generally reddish or orange or can have increased pigmentation maiking them difficult to distinguish from choroidal melanomas.	SNOMEDCT_US:255022003|UMLS:C0346390|NCIT:C3086	hp.json		http://purl.obolibrary.org/obo/HP_0007872		
HP:0005210	biolink:PhenotypicFeature	Hypoplastic colon	Underdevelopment of the colon.	UMLS:C1392839	hp.json	Hypoplasia of the colon|Underdeveloped colon	http://purl.obolibrary.org/obo/HP_0005210		
OBO:MAXO_0000414	biolink:NamedThing	biopsy of trachea	Removal of tissue from the trachea.		hp.json	trachea biopsy	http://purl.obolibrary.org/obo/MAXO_0000414		
OBO:MAXO_0000411	biolink:NamedThing	biopsy of thyroid gland	Removal of tissue from the thyroid gland.		hp.json	thyroid gland biopsy	http://purl.obolibrary.org/obo/MAXO_0000411		
HP:0005211	biolink:PhenotypicFeature	Midgut malrotation		UMLS:C1849706	hp.json		http://purl.obolibrary.org/obo/HP_0005211		
HP:0007874	biolink:PhenotypicFeature	Almond-shaped palpebral fissure	A shape created by an acute downward arching of the upper eyelid and upward arching of the lower eyelid, toward the medial canthus, which gives the outline of the palpebral fissures the configuration of an almond. Thus, the maximum distance between the fissures is offset from, and medial to, the center point.	UMLS:C4024780	hp.json	Almond shaped eyes|Almond-shaped opening between the eyelids	http://purl.obolibrary.org/obo/HP_0007874		hposlim_core
OBO:MAXO_0000412	biolink:NamedThing	biopsy of tongue	Removal of tissue from the tongue.		hp.json	tongue biopsy	http://purl.obolibrary.org/obo/MAXO_0000412		
HP:0007873	biolink:PhenotypicFeature	Abnormally prominent line of Schwalbe		UMLS:C1862376	hp.json	Prominent Schwalbe lines	http://purl.obolibrary.org/obo/HP_0007873		
HP:0005212	biolink:PhenotypicFeature	Anal mucosal leukoplakia	Leukoplakia is a precancerous dermatosis of mucous membranes analogous Leukoplakia is basically a chronic inflammatory hypertrophy in which anaplasia and malignant dyskeratosis may develop and subsequently advance to an invasive squamous cell cancer. The clinical diagnosis of primary anal leukoplakia is indicated by single or multiple slightly raised,irregular, marginated, grayish-white keratinized' patches in the anal canal. Tissue biopsy is necessary for confirmation.	UMLS:C1844632	hp.json		http://purl.obolibrary.org/obo/HP_0005212		
OBO:MAXO_0000417	biolink:NamedThing	biopsy of ureter	Removal of tissue from the ureter.		hp.json	ureter biopsy	http://purl.obolibrary.org/obo/MAXO_0000417		
OBO:MAXO_0000418	biolink:NamedThing	biopsy of urethra	Removal of tissue from the urethra.		hp.json	urethra biopsy	http://purl.obolibrary.org/obo/MAXO_0000418		
OBO:MAXO_0000415	biolink:NamedThing	biopsy of upper digestive tract	Removal of tissue from the upper digestive tract.		hp.json	upper digestive tract biopsy	http://purl.obolibrary.org/obo/MAXO_0000415		
OBO:MAXO_0000416	biolink:NamedThing	biopsy of upper respiratory tract	Removal of tissue from the upper respiratory tract.		hp.json	upper respiratory tract biopsy	http://purl.obolibrary.org/obo/MAXO_0000416		
HP:0007843	biolink:PhenotypicFeature	Attenuation of retinal blood vessels		UMLS:C3278975	hp.json	Narrowing of blood vessels in back of eye	http://purl.obolibrary.org/obo/HP_0007843		
HP:0007841	biolink:PhenotypicFeature	Amyloid deposition in the vitreous humor	Deposition of hyaline extracellular material (amyloid) into the vitreous humor, which can manifest as vitreous opacities and reduced visual acuity.	UMLS:C4024784	hp.json	Vitreous amyloid deposits|Amyloid deposition in the vitreous humour	http://purl.obolibrary.org/obo/HP_0007841		
HP:0007840	biolink:PhenotypicFeature	Long upper eyelashes	Increased length of the upper eyelashes.	UMLS:C4024785	hp.json	Increased length of upper eyelashes|Long upper eyelashes|Ciliary trichomegaly of upper eyelashes	http://purl.obolibrary.org/obo/HP_0007840		
MPATH:429	biolink:NamedThing	myxomatous tumor	Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix.		hp.json		http://purl.obolibrary.org/obo/MPATH_429		
OBO:MAXO_0000431	biolink:NamedThing	MRI of the breast	A medical examination performed using of magnetic resonance imaging to image the breast.		hp.json	breast MRI|breast magnetic resonance imaging|Nuclear magnetic resonance imaging of the breast	http://purl.obolibrary.org/obo/MAXO_0000431		
UBERON:0039355	biolink:AnatomicalEntity	urethral artery		FMA:20903	hp.json	arteria urethralis	http://purl.obolibrary.org/obo/UBERON_0039355		
HP:0007858	biolink:PhenotypicFeature	Chorioretinal lacunae	Punched out lesions in the pigmented layer of the retina.	UMLS:C1844751|UMLS:C4072866	hp.json	Lacunar retinal depigmentation	http://purl.obolibrary.org/obo/HP_0007858		hposlim_core
HP:0007859	biolink:PhenotypicFeature	Congenital horizontal nystagmus	Horizontal nystagmus dating from or present at birth.	UMLS:C1866180	hp.json	Nystagmus, congenital horizontal	http://purl.obolibrary.org/obo/HP_0007859		
HP:0007854	biolink:PhenotypicFeature	Glaucomatous visual field defect		UMLS:C1299694|SNOMEDCT_US:370961005	hp.json		http://purl.obolibrary.org/obo/HP_0007854		
HP:0007856	biolink:PhenotypicFeature	Punctate opacification of the cornea	Punctate opacification (reduced transparency) of the corneal stroma.	UMLS:C4021565	hp.json	Punctate corneal opacities	http://purl.obolibrary.org/obo/HP_0007856		
HP:0007850	biolink:PhenotypicFeature	Retinal vascular proliferation		MSH:D015861|UMLS:C0035320|SNOMEDCT_US:61267008	hp.json		http://purl.obolibrary.org/obo/HP_0007850		
HP:0007852	biolink:PhenotypicFeature	obsolete Pericentral pigmentary retinopathy			hp.json		http://purl.obolibrary.org/obo/HP_0007852		
HP:0007851	biolink:PhenotypicFeature	obsolete Temporal displacement of maculae			hp.json		http://purl.obolibrary.org/obo/HP_0007851		
UBERON:0003328	biolink:AnatomicalEntity	mesenchyme of footplate	Mesenchyme that is part of a footplate.	EHDAA:5149|VHOG_RETIRED:0001055|EMAPA:17252|EHDAA2:0000549|EHDAA:6172|EMAPA:17488	hp.json	foot plate mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003328		
UBERON:0003329	biolink:AnatomicalEntity	submucosa of anal canal	A submucosa that is part of an anal canal [Automatically generated definition].	FMA:85399|EMAPA:27217|EMAPA:27227|EMAPA:27535|SCTID:7892006	hp.json	submucosa of anal canal viewed anatomically|submucosa of anatomical anal canal|anal canal submucosa|anatomical anal canal submucosa|submucosa of anal region|anal canal viewed anatomically submucosa|anal region submucosa	http://purl.obolibrary.org/obo/UBERON_0003329		human_reference_atlas
UBERON:0005992	biolink:AnatomicalEntity	pulmonary valve cusp	The three fibrous triangular components and associated flap of the pulmonary valve.	FMA:7248	hp.json	pulmonary semilunar valvule|semilunar cusp of pulmonary valve|cusp of pulmonary valve|semilunar valvule of pulmonary valve|pulmonary valvular cusp	http://purl.obolibrary.org/obo/UBERON_0005992		pheno_slim
UBERON:0003330	biolink:AnatomicalEntity	submucosa of rectum	The submucous layer of the wall of the rectum.	EMAPA:27083|SCTID:71683001|BTO:0002114|FMA:15034	hp.json	rectal submucosa|tela submucosa recti|rectum submucosa	http://purl.obolibrary.org/obo/UBERON_0003330		
UBERON:0005991	biolink:AnatomicalEntity	aortic valve anulus	The fibrous ring of the aortic valve that attaches the cusps of aortic valve to the wall of left ventricle, and which consists of portions of the fibrous scallops of the posterior, right anterior and left anterior cusps.	FMA:9502|EMAPA:37418	hp.json	fibrous ring of aortic valve|aortic anulus|aortic valvar anulus|anulus of aortic valve	http://purl.obolibrary.org/obo/UBERON_0005991		pheno_slim
UBERON:0005990	biolink:AnatomicalEntity	aortic valve cusp	The three fibrous triangular components and associated flap of the aortic valve.	FMA:7251	hp.json	aortic semilunar valvule|semilunar valvule of aortic valve|cusp of aortic valve|aortic valvular cusp	http://purl.obolibrary.org/obo/UBERON_0005990		pheno_slim
UBERON:0003337	biolink:AnatomicalEntity	serosa of jejunum	A serous membrane that is part of a jejunum [Automatically generated definition].	FMA:14955|EMAPA:27115	hp.json	visceral peritoneum of jejunum|jejunum serous membrane|jejunal serosa|serous membrane of jejunum|jejunum serosa	http://purl.obolibrary.org/obo/UBERON_0003337		human_reference_atlas
UBERON:0003338	biolink:AnatomicalEntity	ganglion of peripheral nervous system	A spatially aggregated collection of nerve cell bodies in the PNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections. (CUMBO).	MA:0001161|BIRNLEX:2548|BTO:0001123|EMAPA:32814	hp.json	peripheral nervous system ganglion	http://purl.obolibrary.org/obo/UBERON_0003338		cumbo
UBERON:0005998	biolink:AnatomicalEntity	tricuspid valve cusp	The three fibrous triangular components and associated flaps of the tricuspid valve.	FMA:7240	hp.json	septal leaflet of right-sided tricuspid valve|septal cusp of tricuspid valve|septal leaflet of tricuspid valve|cuspis septalis valvae atrioventricularis dextrae|septal cusp of right atrioventricular valve|cuspis septalis (valva tricuspidalis)|septal tricuspid leaflet	http://purl.obolibrary.org/obo/UBERON_0005998		pheno_slim
UBERON:0003335	biolink:AnatomicalEntity	serosa of colon	A serous membrane that is part of a colon [Automatically generated definition].	MA:0003199|SCTID:90132000|EMAPA:27387|FMA:14990	hp.json	colonic serosa|serosa of large bowel|colon serous membrane|large bowel serous membrane|large bowel serosa|serous membrane of colon|visceral peritoneum of colon|colon serosa|serous membrane of large bowel	http://purl.obolibrary.org/obo/UBERON_0003335		human_reference_atlas
MPATH:404	biolink:NamedThing	soft tissue tumor	Neoplasms of the soft and connective tissues.		hp.json		http://purl.obolibrary.org/obo/MPATH_404		
UBERON:0003336	biolink:AnatomicalEntity	serosa of duodenum	A serous membrane that is part of a duodenum [Automatically generated definition].	EMAPA:27247|FMA:14948|MA:0003212	hp.json	duodenal serosa|duodenum serosa|doudenal serosa|serous membrane of duodenum|visceral peritoneum of duodenum|duodenum serous membrane	http://purl.obolibrary.org/obo/UBERON_0003336		
UBERON:0005997	biolink:AnatomicalEntity	tricuspid valve anulus	The fibrous ring of the tricuspid valve that attaches the cusps of tricuspid valve to the heart, and which consists of portions of the fibrous scallops of the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp).	EMAPA:37421|FMA:9500	hp.json	tricuspid valvar anulus|tricuspid anulus|anulus of tricuspid valve|fibrous ring of tricuspid valve	http://purl.obolibrary.org/obo/UBERON_0005997		pheno_slim
UBERON:0005996	biolink:AnatomicalEntity	mitral valve cusp	The two fibrous components and associated flaps of the mitral valve.		hp.json		http://purl.obolibrary.org/obo/UBERON_0005996		pheno_slim
UBERON:0003333	biolink:AnatomicalEntity	submucosa of jejunum	A submucosa that is part of a jejunum [Automatically generated definition].	FMA:14950|EMAPA:27111	hp.json	jejunal submucosa|jejunum submucosa	http://purl.obolibrary.org/obo/UBERON_0003333		human_reference_atlas
CHEBI:2571	biolink:ChemicalSubstance	aliphatic alcohol	An  alcohol derived from an aliphatic compound.	KEGG:C02525	hp.json	aliphatic alcohols|an aliphatic alcohol|Aliphatic alcohol	http://purl.obolibrary.org/obo/CHEBI_2571		3_STAR
UBERON:0005995	biolink:AnatomicalEntity	mitral valve anulus	The fibrous ring of the mitral valve that attaches the cusps of mitral valve to the heart, and which consists of portions of the fibrous scallops of the anterior and posterior cusps.	EMAPA:37419|FMA:9498	hp.json	anulus of mitral valve|mitral anulus|mitral annulus|fibrous ring of mitral valve|mitral valvar anulus	http://purl.obolibrary.org/obo/UBERON_0005995		pheno_slim
UBERON:0003334	biolink:AnatomicalEntity	serosa of rectum	A serous membrane that is part of a rectum [Automatically generated definition].	FMA:15039|EMAPA:27087	hp.json	rectum serous membrane|rectum serosa|visceral peritoneum of rectum|rectal serosa|serous membrane of rectum	http://purl.obolibrary.org/obo/UBERON_0003334		
UBERON:0005994	biolink:AnatomicalEntity	chorda tendineae	The tendinous strands that connect the papillary muscles on the wall of the ventricles to the leaflets of the atrioventricular valves; the chordae tendineae serve to prevent the AV valves from prolapsing back into the atria.	UMLS:C0008484|FMA:12225|NCIT:C32307|MESH:D002815|EMAPA:36322|GAID:564	hp.json	chordae tendinea|chordae tendineae cordis	http://purl.obolibrary.org/obo/UBERON_0005994		pheno_slim
UBERON:0003331	biolink:AnatomicalEntity	submucosa of colon	A submucosa that is part of a colon [Automatically generated definition].	SCTID:61647009|FMA:14985|EMAPA:27379|MA:0003200	hp.json	submucosa of large bowel|colon submucosa|large bowel submucosa|colonic submucosa	http://purl.obolibrary.org/obo/UBERON_0003331		human_reference_atlas
UBERON:0003332	biolink:AnatomicalEntity	submucosa of duodenum	A submucosa that is part of a duodenum [Automatically generated definition].	FMA:14943|EMAPA:27239|EMAPA:27027|MA:0003213|EMAPA:27097	hp.json	duodenal submucosa|doudenal submucosa|duodenum submucosa	http://purl.obolibrary.org/obo/UBERON_0003332		human_reference_atlas
UBERON:0005993	biolink:AnatomicalEntity	pulmonary valve anulus	The fibrous ring of the pulmonary valve that attaches the cusps of pulmonary valve to the wall of right ventricle, and which consists of portions of the fibrous scallops of the anterior, right posterior and left posterior cusps.	EMAPA:37420|FMA:9503	hp.json	fibrous ring of pulmonary valve|pulmonary valvar anulus|pulmonary anulus|anulus of pulmonary valve	http://purl.obolibrary.org/obo/UBERON_0005993		pheno_slim
UBERON:0003319	biolink:AnatomicalEntity	mesenchyme of carpal region	Mesenchyme of the carpal region that contributes to the carpal skeleton.	EMAPA:19122|EHDAA2:0000220|EHDAA:5200	hp.json	mesenchyme of wrist|carpus mesenchyme|carpal region mesenchyme|wrist mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003319		
UBERON:0003317	biolink:AnatomicalEntity	odontogenic papilla of incisor	An odontogenic papilla that is part of a incisor tooth [Automatically generated definition].	MA:0003231|EMAPA:32893	hp.json	incisor odontogenic papilla|odontogenic papilla of incisor tooth|incisor dental papilla|incisor tooth odontogenic papilla	http://purl.obolibrary.org/obo/UBERON_0003317		
UBERON:0005979	biolink:AnatomicalEntity	crista terminalis	The vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium.	Wikipedia:Crista_terminalis|FMA:9236|SCTID:277693004|EMAPA:37837	hp.json	crista terminalis cordis|crista terminalis of right atrium|crista terminalis atrii dextri	http://purl.obolibrary.org/obo/UBERON_0005979		pheno_slim
UBERON:0003318	biolink:AnatomicalEntity	mesenchyme of elbow	Mesenchyme that is part of a developing elbow [Automatically generated definition].	VHOG:0001075|EHDAA2:0000432|EHDAA:6216|EMAPA:17416|EHDAA:4170	hp.json	mesenchyme of cubital region|cubital region mesenchyme|elbow mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003318		
PATO:0070060	biolink:NamedThing	quality of interaction of a substance with electromagnetic radiation	A quality of a substance on which or through which electromagnetic radiation impinges or traverses with respect to radiation. This substance quality changes the quality of the incident radiation with respect to any of: intensity, direction, scatter and wavelength.		hp.json		http://purl.obolibrary.org/obo/PATO_0070060		attribute_slim
UBERON:0003326	biolink:AnatomicalEntity	mesenchyme of mammary gland	Mesenchyme that is part of a developing mammary gland.	EHDAA2:0001058|VHOG:0001087|EHDAA:6528|EMAPA:17761	hp.json	lobe of breast mesenchyme|lactiferous gland mesenchyme|mesenchyme of lobe of mammary gland|mammary mesenchyme|mammary gland mesenchyme|lobe of mammary gland mesenchyme|mesenchyme of lactiferous gland|mesenchyme of lobe of breast	http://purl.obolibrary.org/obo/UBERON_0003326		
UBERON:0005989	biolink:AnatomicalEntity	atrioventricular septum	The wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve.	SCTID:280151006|EMAPA:37431|Wikipedia:Atrioventricular_septum|FMA:7136	hp.json	membranous atrioventricular septum	http://purl.obolibrary.org/obo/UBERON_0005989		pheno_slim
UBERON:0003327	biolink:AnatomicalEntity	mesenchyme of forearm	Mesenchyme that is part of a developing lower arm [Automatically generated definition].	EHDAA2:0000555|VHOG:0000504|EMAPA:17419|EHDAA:6222|EHDAA:4176	hp.json		http://purl.obolibrary.org/obo/UBERON_0003327		
UBERON:0005988	biolink:AnatomicalEntity	atrium myocardial trabecula	The supporting bundles of muscular fibers lining the walls of the atrial myocardium.	EMAPA:37432|ZFA:0005810	hp.json	trabecula of atrium|trabecular layer of the atrium|atrial trabecula|atrium myocardial trabeculae|trabecular layer of atrium	http://purl.obolibrary.org/obo/UBERON_0005988		pheno_slim
UBERON:0003324	biolink:AnatomicalEntity	mesenchyme of lower jaw	Mesenchyme that is part of a developing lower jaw [Automatically generated definition].	EHDAA2:0001024|EMAPA:17916|EHDAA:8003|VHOG:0001069	hp.json	lower jaw mesenchyme|ventral mandibular arch mesenchyme|mesenchyme of ventral mandibular arch	http://purl.obolibrary.org/obo/UBERON_0003324		
CHEBI:2580	biolink:ChemicalSubstance	unsaturated fatty acid anion	Any fatty acid anion containing at least one C-C unsaturated bond; formed by deprotonation of the carboxylic acid moiety.		hp.json		http://purl.obolibrary.org/obo/CHEBI_2580		3_STAR
UBERON:0003325	biolink:AnatomicalEntity	mesenchyme of pinna	Mesenchyme that is part of a developing pinna [Automatically generated definition].	VHOG:0000747|EMAPA:17591|EHDAA:8981|EHDAA2:0001469	hp.json	mesenchyme of auricula (auris externa)|mesenchyme of auricle of external ear|auricle mesenchyme|mesenchyme of pinna of ear|auricula mesenchyme|pinna of ear mesenchyme|mesenchyme of auricula|pinna mesenchyme|mesenchyme of auricle|auricula (auris externa) mesenchyme|auricle of external ear mesenchyme|mesenchyme of auricle of ear|auricle of ear mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003325		
UBERON:0005985	biolink:AnatomicalEntity	coronary vessel	Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation.	MESH:D003331|Wikipedia:Coronary_circulation	hp.json		http://purl.obolibrary.org/obo/UBERON_0005985		pheno_slim
UBERON:0003322	biolink:AnatomicalEntity	mesenchyme of shoulder	Mesenchyme that is part of a developing shoulder [Automatically generated definition].	EHDAA:6232|EHDAA:4184|EHDAA2:0001837|VHOG:0001035|EMAPA:17423	hp.json	shoulder mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003322		
OIO:hasNarrowSynonym	biolink:NamedThing	has_narrow_synonym			hp.json		http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym		
UBERON:0003323	biolink:AnatomicalEntity	mesenchyme of upper jaw	Mesenchyme that is part of a developing upper jaw [Automatically generated definition].	EMAPA:17929|EHDAA2:0002124|VHOG:0001099|EHDAA:8031	hp.json	palatoquadrate arch mesenchyme|upper jaw mesenchyme|mesenchyme of palatoquadrate arch	http://purl.obolibrary.org/obo/UBERON_0003323		
UBERON:0003320	biolink:AnatomicalEntity	mesenchyme of hip	Mesenchyme that is part of a developing hip [Automatically generated definition].	EHDAA:5157|EMAPA:17492|VHOG:0001029|EHDAA:6182|EHDAA2:0000786	hp.json	mesenchyme of regio coxae|hip mesenchyme|mesenchyme of hip region|hip region mesenchyme|regio coxae mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003320		
UBERON:0005983	biolink:AnatomicalEntity	heart layer	The laminar structure of the heart.		hp.json		http://purl.obolibrary.org/obo/UBERON_0005983		pheno_slim|non_informative
UBERON:0003321	biolink:AnatomicalEntity	mesenchyme of knee	Mesenchyme that is part of a developing knee [Automatically generated definition].	VHOG:0001070|EHDAA:6188|EHDAA:5163|EHDAA2:0000898|EMAPA:17495	hp.json	knee mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003321		
UBERON:0005969	biolink:AnatomicalEntity	eye trabecular meshwork	A pore-like structure surrounding the entire circumference of the anterior chamber of the eye through which aqueous humor circulates[MP].	BTO:0001605|MESH:D014129|UMLS:C0040573|EV:0100352|MA:0003086|EFO:0003077|NCIT:C12803|GAID:897|CALOHA:TS-1058|FMA:77660	hp.json	cribiform ligament|reticulum trabeculare sclerae|ligamentum peactin-tum iridis|reticulum trabeculare|iridis|pectinate ligament|pectinate ligament of iris|trabecular meshwork|ligamentum pectinatum|Hueck's ligament|ligamentum pectinatum anguli iridocornealis|trabecular mesh|eye trabecular meshwork|trabecular meshwork of the eye|ligamentum pectinatum iridis|scleral trabecule|scleral trabeculae|scribiform ligament|scleral trabecular	http://purl.obolibrary.org/obo/UBERON_0005969		pheno_slim|efo_slim
CHEBI:22323	biolink:ChemicalSubstance	alkyl group	A univalent group -CnH2n+1 derived from an alkane by removal of a hydrogen atom from any carbon atom.		hp.json	groupe alkyle|grupos alquilo|grupo alquilo|alkyl group|alkyl groups	http://purl.obolibrary.org/obo/CHEBI_22323		3_STAR
NCBITaxon:9526	biolink:OrganismalEntity	Catarrhini			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_9526		
UBERON:1000006	biolink:AnatomicalEntity	collection of hair on forehead	A collection of hairs that grows on the forehead.		hp.json		http://purl.obolibrary.org/obo/UBERON_1000006		phenotype_rcn
CHEBI:36962	biolink:ChemicalSubstance	organochalcogen compound	An organochalcogen compound is a compound containing at least one carbon-chalcogen bond.		hp.json	organochalcogen compound|organochalcogen compounds	http://purl.obolibrary.org/obo/CHEBI_36962		3_STAR
UBERON:0005970	biolink:AnatomicalEntity	brain commissure	Any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain.	EMAPA:37446	hp.json		http://purl.obolibrary.org/obo/UBERON_0005970		pheno_slim
CHEBI:36963	biolink:ChemicalSubstance	organooxygen compound	An organochalcogen compound containing at least one carbon-oxygen bond.	PMID:17586126	hp.json	organooxygen compounds|organooxygen compound	http://purl.obolibrary.org/obo/CHEBI_36963		3_STAR
OBO:MAXO_0000408	biolink:NamedThing	biopsy of submandibular gland	Removal of tissue from the submandibular gland.		hp.json	submandibular gland biopsy	http://purl.obolibrary.org/obo/MAXO_0000408		
CHEBI:36961	biolink:ChemicalSubstance	chalcocarbonic acid			hp.json	chalcocarbonic acids|chalcocarbonic acids|chalcocarbonic acid	http://purl.obolibrary.org/obo/CHEBI_36961		3_STAR
OBO:MAXO_0000409	biolink:NamedThing	biopsy of testis	Removal of tissue from the testis.		hp.json	testis biopsy	http://purl.obolibrary.org/obo/MAXO_0000409		
UBERON:1000015	biolink:AnatomicalEntity	skin of snout	A zone of skin that is part of the snout.	EMAPA:37746|MA:0003079	hp.json	snout skin	http://purl.obolibrary.org/obo/UBERON_1000015		phenotype_rcn
UBERON:0003315	biolink:AnatomicalEntity	mesenchyme of ovary	Mesenchyme that is part of a developing ovary [Automatically generated definition].	EHDAA:8128|EHDAA2:0001362|VHOG:0001441	hp.json	mesenchyme of female reproductive system gonad|mesenchyme of female reproductive system gonada|gonada of female reproductive system mesenchyme|ovary mesenchyme|gonad of female reproductive system mesenchyme|mesenchyme of gonada of female reproductive system|mesenchyme of gonad of female reproductive system|female reproductive system gonad mesenchyme|female reproductive system gonada mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003315		
OBO:MAXO_0000402	biolink:NamedThing	biopsy of sebaceous gland	Removal of tissue from the sebaceous gland.		hp.json	sebaceous gland biopsy	http://purl.obolibrary.org/obo/MAXO_0000402		
UBERON:0003316	biolink:AnatomicalEntity	mesenchyme of yolk sac	The portion of the yolk sac that is derived from mesoderm and consists of mesenchyme.	VHOG:0000617|EHDAA2:0002216|EHDAA:168|EMAPA:16087|VHOG:0000503|EHDAA:205|EMAPA:16267	hp.json	yolk sac mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003316		
OBO:MAXO_0000403	biolink:NamedThing	biopsy of small intestine	Removal of tissue from the small intestine.		hp.json	small intestine biopsy	http://purl.obolibrary.org/obo/MAXO_0000403		
GO:0070455	biolink:BiologicalProcess	positive regulation of heme biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.		hp.json	activation of heme biosynthetic process|positive regulation of heme biosynthesis|stimulation of heme biosynthetic process|upregulation of heme biosynthetic process|positive regulation of heme anabolism|positive regulation of heme synthesis|up-regulation of heme biosynthetic process|positive regulation of haem biosynthetic process|positive regulation of heme formation|up regulation of heme biosynthetic process	http://purl.obolibrary.org/obo/GO_0070455		
OBO:MAXO_0000400	biolink:NamedThing	biopsy of saliva-secreting gland	Removal of tissue from the saliva-secreting gland.		hp.json	saliva-secreting gland biopsy	http://purl.obolibrary.org/obo/MAXO_0000400		
OBO:MAXO_0000401	biolink:NamedThing	biopsy of scrotum	Removal of tissue from the scrotum.		hp.json	scrotum biopsy	http://purl.obolibrary.org/obo/MAXO_0000401		
UBERON:0003314	biolink:AnatomicalEntity	eye mesenchyme	Mesenchyme that is part of a developing camera-type eye.	VHOG:0001084|EHDAA2:0000485|EHDAA:2910|EMAPA:16673	hp.json	mesenchyme of eye	http://purl.obolibrary.org/obo/UBERON_0003314		
OBO:MAXO_0000406	biolink:NamedThing	biopsy of stomach	Removal of tissue from the stomach.		hp.json	stomach biopsy	http://purl.obolibrary.org/obo/MAXO_0000406		
GO:0070453	biolink:BiologicalProcess	regulation of heme biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.		hp.json	regulation of heme synthesis|regulation of heme formation|regulation of haem biosynthetic process|regulation of haem biosynthesis|regulation of heme biosynthesis|regulation of heme anabolism	http://purl.obolibrary.org/obo/GO_0070453		
UBERON:0003312	biolink:AnatomicalEntity	mesenchyme of testis	Mesenchyme that is part of a developing testis [Automatically generated definition].	EMAPA:35858|EHDAA2:0002010|VHOG:0001442|EHDAA:8150	hp.json	testis mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003312		
GO:0070454	biolink:BiologicalProcess	negative regulation of heme biosynthetic process	Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.		hp.json	negative regulation of haem biosynthetic process|negative regulation of heme anabolism|negative regulation of heme biosynthesis|down-regulation of heme biosynthetic process|negative regulation of heme synthesis|down regulation of heme biosynthetic process|negative regulation of heme formation|inhibition of heme biosynthetic process|downregulation of heme biosynthetic process	http://purl.obolibrary.org/obo/GO_0070454		
OBO:MAXO_0000407	biolink:NamedThing	biopsy of subglottis	Removal of tissue from the subglottis.		hp.json	subglottis biopsy	http://purl.obolibrary.org/obo/MAXO_0000407		
OBO:MAXO_0000404	biolink:NamedThing	biopsy of spinal cord	Removal of tissue from the spinal cord.		hp.json	spinal cord biopsy	http://purl.obolibrary.org/obo/MAXO_0000404		
GO:0070451	biolink:NamedThing	cell hair			hp.json		http://purl.obolibrary.org/obo/GO_0070451		
UBERON:0005971	biolink:AnatomicalEntity	amniotic fold	A sheet of somatopleure that grows upward over the embryo and eventually meets in the midline enclosing the embryo, eventually giving rise to the amnion and chorion[Kardong].	EMAPA:16076	hp.json	amnionic fold|amnionic fold	http://purl.obolibrary.org/obo/UBERON_0005971		pheno_slim
OBO:MAXO_0000405	biolink:NamedThing	biopsy of spleen	Removal of tissue from the spleen.		hp.json	spleen biopsy	http://purl.obolibrary.org/obo/MAXO_0000405		
CHEBI:24995	biolink:ChemicalSubstance	lactam	Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.		hp.json	Laktam|lactam|lactams|lactams|Laktame	http://purl.obolibrary.org/obo/CHEBI_24995		3_STAR
CHEBI:22331	biolink:ChemicalSubstance	alkylamines	Any amine formally derived from ammonia by replacing one, two or three hydrogen atoms by alkyl groups.		hp.json		http://purl.obolibrary.org/obo/CHEBI_22331		3_STAR
CHEBI:48944	biolink:ChemicalSubstance	isobutyrate	A branched, short-chain, saturated fatty acid anion; the conjugate base of isobutyric acid, formed by deprotonation of the carboxylic acid group.	Beilstein:3903644|Reaxys:3903644|Gmelin:324364|UM-BBD_compID:c0383|CAS:5711-69-3|CAS:5711-69-3|MetaCyc:ISOBUTYRATE	hp.json	2-methylpropanoate|iPrCO2 anion|2-methylpropanoate|isobutanoate|i-butyrate|isobutyric acid anion|Isobutyrat|2-methylpropionate|methylpropanoate|2-methylpropanoic acid, ion(1-)	http://purl.obolibrary.org/obo/CHEBI_48944		3_STAR
CHEBI:24996	biolink:ChemicalSubstance	lactate	A hydroxy monocarboxylic acid anion that is the conjugate base of lactic acid, arising from deprotonation of the carboxy group.	KEGG:C01432|MetaCyc:Lactate|CAS:113-21-3|Gmelin:240074|Beilstein:3587719|CAS:113-21-3	hp.json	2-hydroxypropanoate|2-hydroxypropionate|MeCH(OH)CO2 anion|2-hydroxypropanoic acid, ion(1-)|b-lactate|lactate|beta-lactate	http://purl.obolibrary.org/obo/CHEBI_24996		3_STAR
PATO:0070044	biolink:NamedThing	anatomical structure quality	A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components.		hp.json		http://purl.obolibrary.org/obo/PATO_0070044		
PATO:0070045	biolink:NamedThing	anatomical histological quality	A quality inhering in an anotomical structure by virtue of its capacity to be stained by specific histological dyes.		hp.json		http://purl.obolibrary.org/obo/PATO_0070045		
PATO:0070046	biolink:NamedThing	neutrophillic	An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction that stains and colors, pale-pink, with Wright-Giemsa stain.		hp.json		http://purl.obolibrary.org/obo/PATO_0070046		
PATO:0070047	biolink:NamedThing	polychromatophilic	An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for both basic and acid stains under specific pH conditions.		hp.json		http://purl.obolibrary.org/obo/PATO_0070047		
UBERON:1000021	biolink:AnatomicalEntity	skin of face	A zone of skin that is part of the face.	SCTID:361703006|UMLS:C0222084|FMA:24758|NCIT:C33561|EMAPA:36657	hp.json	facial skin|face skin	http://purl.obolibrary.org/obo/UBERON_1000021		phenotype_rcn|pheno_slim
UBERON:1000020	biolink:AnatomicalEntity	collection of hair on snout	A collection of hairs that grows on the snout.		hp.json		http://purl.obolibrary.org/obo/UBERON_1000020		phenotype_rcn
UBERON:1000023	biolink:AnatomicalEntity	spleen pulp	The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages.	NCIT:C33603|MA:0002487|EMAPA:35805|FMA:15845|UMLS:C0229691	hp.json	pulp of spleen|splenic pulp|Malpighian corpuscles	http://purl.obolibrary.org/obo/UBERON_1000023		human_reference_atlas
UBERON:1000024	biolink:AnatomicalEntity	parenchyma of spleen	A parenchyma that is part of a spleen.	FMA:16029	hp.json	splenic parenchyma	http://purl.obolibrary.org/obo/UBERON_1000024		
GO:0070446	biolink:BiologicalProcess	negative regulation of oligodendrocyte progenitor proliferation	Any process that stops or decreases the rate or extent of oligodendrocyte progenitor proliferation.		hp.json	negative regulation of oligodendrocyte precursor proliferation	http://purl.obolibrary.org/obo/GO_0070446		
UBERON:0003304	biolink:AnatomicalEntity	mesoderm blood island	A blood island that is part of a mesoderm.	EHDAA2:0003241|EHDAA:170|EMAPA:16115	hp.json	mesenchyme blood island|mesoderm blood islands	http://purl.obolibrary.org/obo/UBERON_0003304		
UBERON:0005966	biolink:AnatomicalEntity	outflow part of left atrium	An outflow tract of atrium that is part of a left atrium.	FMA:9551	hp.json	outflow tract of left atrium|main part of left atrium	http://purl.obolibrary.org/obo/UBERON_0005966		
GO:0070447	biolink:BiologicalProcess	positive regulation of oligodendrocyte progenitor proliferation	Any process that activates or increases the rate or extent of oligodendrocyte progenitor proliferation.		hp.json	positive regulation of oligodendrocyte precursor proliferation	http://purl.obolibrary.org/obo/GO_0070447		
GO:0070444	biolink:BiologicalProcess	oligodendrocyte progenitor proliferation	The multiplication or reproduction of oligodendrocyte progenitor cells by cell division, resulting in the expansion of their population. Oligodendrocyte progenitors give rise to oligodendrocytes, which form the insulating myelin sheath of axons in the central nervous system.		hp.json	oligodendrocyte precursor proliferation	http://purl.obolibrary.org/obo/GO_0070444		
UBERON:0003302	biolink:AnatomicalEntity	roof plate of metencephalon	A roof plate that is part of a metencephalon [Automatically generated definition].	EHDAA:5524|EMAPA:16483|EHDAA2:0001160|VHOG:0000770|EMAPA:16487	hp.json	roofplate of metencephalon|epencephalon-2 roof plate|metencephalon roofplate|roofplate of epencephalon-2|roof plate metencephalon|metencephalon roof plate|roof plate of epencephalon-2|epencephalon-2 roofplate|roofplate medulla metencephalon	http://purl.obolibrary.org/obo/UBERON_0003302		
UBERON:0005965	biolink:AnatomicalEntity	outflow part of right atrium	Outflow part of atrium which consists of wall and cavity of the outflow part of right atrium and the tricuspid valve.[FMA].	FMA:9550	hp.json	outflow tract of right atrium|main part of right atrium	http://purl.obolibrary.org/obo/UBERON_0005965		
UBERON:0003303	biolink:AnatomicalEntity	roof plate of medulla oblongata	A roof plate that is part of a medulla oblongata [Automatically generated definition].	EHDAA:7614|VHOG:0000776|EHDAA2:0001099	hp.json	roofplate of medulla oblongata|roof plate of bulb|roof plate medulla oblongata|bulb roofplate|medulla oblongata roofplate|roofplate of metepencephalon|roof plate of medulla oblonmgata|metepencephalon roof plate|medulla oblonmgata roof plate|metepencephalon roofplate|medulla oblonmgata roofplate|roofplate of bulb|medulla oblongata roof plate|roof plate of metepencephalon|bulb roof plate|roofplate medulla oblongata|roofplate of medulla oblonmgata	http://purl.obolibrary.org/obo/UBERON_0003303		
GO:0070445	biolink:BiologicalProcess	regulation of oligodendrocyte progenitor proliferation	Any process that modulates the frequency, rate or extent of oligodendrocyte progenitor proliferation.		hp.json	regulation of oligodendrocyte precursor proliferation	http://purl.obolibrary.org/obo/GO_0070445		
UBERON:0003300	biolink:AnatomicalEntity	roof plate of telencephalon	A roof plate that is part of a telencephalon [Automatically generated definition].	EHDAA:3512|EHDAA2:0001994|VHOG:0000774|EMAPA:16657	hp.json	roofplate of telencephalon|telencephalon roofplate|roofplate medulla telencephalon|telencephalon roof plate|roof plate telencephalon	http://purl.obolibrary.org/obo/UBERON_0003300		
UBERON:0003301	biolink:AnatomicalEntity	roof plate of diencephalon	A roof plate that is part of a diencephalon [Automatically generated definition].	EHDAA2:0000402|EMAPA:16909|TAO:0001358|EHDAA:3494|EHDAA:1979|VHOG:0000771|ZFA:0001358|EHDAA:2657	hp.json	roof plate of interbrain|roofplate of diencephalon|mature diencephalon roofplate|interbrain roofplate|between brain roof plate|roof plate of between brain|diencephalon roof plate|roof plate diencephalon|roof plate of mature diencephalon|roofplate of interbrain|diencephalon roofplate|roofplate of between brain|roofplate medulla diencephalon|roof plate diencephalic region|interbrain roof plate|mature diencephalon roof plate|between brain roofplate|roofplate of mature diencephalon	http://purl.obolibrary.org/obo/UBERON_0003301		vertebrate_core
CHEBI:24961	biolink:ChemicalSubstance	ketoaldonate			hp.json	ketoaldonate|ketoaldonates	http://purl.obolibrary.org/obo/CHEBI_24961		3_STAR
CHEBI:22301	biolink:ChemicalSubstance	aldonic acid	Any carbohydrate acid formed by oxidising the aldehyde functional group of an aldose to a carboxylic acid functional group. Aldonic acids have the general formula HOCH2[CH(OH)]nC(=O)OH.		hp.json	aldonic acid|aldonic acids	http://purl.obolibrary.org/obo/CHEBI_22301		3_STAR
CHEBI:24963	biolink:ChemicalSubstance	ketoaldonic acid	Oxo carboxylic acids formally derived from aldonic acids by replacement of a secondary CHOH group by a carbonyl group.		hp.json	ketoaldonic acid|ketoaldonic acids	http://purl.obolibrary.org/obo/CHEBI_24963		3_STAR
UBERON:0003373	biolink:AnatomicalEntity	ectoderm of footplate	An ectoderm that is part of a footplate.	EMAPA:17250	hp.json		http://purl.obolibrary.org/obo/UBERON_0003373		
UBERON:0003374	biolink:AnatomicalEntity	chorionic ectoderm	An extraembryonic structure that develops_from a ectoderm and is part of a chorion.	BTO:0005145|EMAPA:16113	hp.json	chorionic epithelium|chorion ectoderm|chorion epithelium	http://purl.obolibrary.org/obo/UBERON_0003374		
UBERON:0003371	biolink:AnatomicalEntity	pelvic appendage bud ectoderm	An unilaminar epithelium that surrounds a pelvic appendage bud.	EMAPA:16780|EHDAA2:0001034|VHOG:0001048	hp.json	hindlimb bud ectoderm|hindlimb ectoderm|hindlimb ectoderm|lower limb bud ectoderm|pelvic fin bud ectoderm|hindlimb bud ectoderm|leg ectoderm	http://purl.obolibrary.org/obo/UBERON_0003371		
UBERON:0003372	biolink:AnatomicalEntity	pectoral appendage bud ectoderm	An unilaminar epithelium that surrounds a pectoral appendage bud.	EHDAA2:0002134|EMAPA:16407|VHOG:0001047	hp.json	wing ectoderm|forelimb bud ectoderm|forelimb bud ectoderm|pectoral fin bud ectoderm|upper limb bud ectoderm|forelimb ectoderm|arm ectoderm	http://purl.obolibrary.org/obo/UBERON_0003372		
CHEBI:48937	biolink:ChemicalSubstance	phytane		Beilstein:1744639|CAS:638-36-8	hp.json	2,6,10,14-tetramethylhexadecane|Phytan	http://purl.obolibrary.org/obo/CHEBI_48937		3_STAR
UBERON:0003379	biolink:AnatomicalEntity	cardiac muscle of right atrium	A portion of cardiac muscle tissue that is part of a right atrium [Automatically generated definition].	EMAPA:17326|SCTID:362018002|VHOG:0001227|FMA:7282|EHDAA2:0004155	hp.json	right atrium myocardium|right atrium heart muscle|cardiac muscle of heart right atrium|cardiac muscle tissue of right atrium of heart|cardiac muscle tissue of right atrium|myocardium of right atrium|textus muscularis of myocardium of right cardiac atrium|cardiac muscle of cardiac right atrium|textus muscularis of myocardium of right atrium of heart|cardiac muscle tissue of heart right atrium|textus muscularis of myocardium of right atrium	http://purl.obolibrary.org/obo/UBERON_0003379		
CHEBI:22314	biolink:ChemicalSubstance	alkali metal atom			hp.json	alkali metals|metal alcalino|metal alcalin|alkali metal|metaux alcalins|Alkalimetall|Alkalimetalle|metales alcalinos	http://purl.obolibrary.org/obo/CHEBI_22314		3_STAR
CHEBI:22315	biolink:ChemicalSubstance	alkaloid	Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is  exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.	Wikipedia:Alkaloid	hp.json	alcaloide|alkaloids|Alkaloide|alcaloides|Alkaloid	http://purl.obolibrary.org/obo/CHEBI_22315		3_STAR
CHEBI:22313	biolink:ChemicalSubstance	alkaline earth metal atom			hp.json	alkaline earth metals|metal alcalinoterreo|Erdalkalimetalle|alkaline-earth metals|Erdalkalimetall|metal alcalino-terreux|alkaline-earth metal|metaux alcalino-terreux|metales alcalinoterreos|alkaline earth metal	http://purl.obolibrary.org/obo/CHEBI_22313		3_STAR
UBERON:0003360	biolink:AnatomicalEntity	epithelium of parotid gland	An epithelium that is part of a parotid gland [Automatically generated definition].	VHOG:0001434|BTO:0004555|EMAPA:18538	hp.json	parotid gland duct epithelium|epithelium of parotid|epithelial tissue of parotid gland|parotid gland epithelial tissue|parotid epithelial tissue|parotid epithelium|parotid gland epithelium|epithelium of parotid gland	http://purl.obolibrary.org/obo/UBERON_0003360		
UBERON:0003361	biolink:AnatomicalEntity	epithelium of sublingual gland	An epithelium that is part of a sublingual gland [Automatically generated definition].	EMAPA:18810|VHOG:0001098|BTO:0004559	hp.json	epithelial tissue of ductus sublingualis|epithelial tissue of sublingual gland|ductus sublingualis epithelial tissue|sublingual gland epithelium|epithelium of Rivinus'gland|Rivinus'gland epithelium|epithelial tissue of Rivinus'gland|Rivinus'gland epithelial tissue|sublingual gland epithelial tissue|sublingual gland duct epithelium|ductus sublingualis epithelium|sublingual duct epithelium|epithelium of ductus sublingualis	http://purl.obolibrary.org/obo/UBERON_0003361		
GO:0070469	biolink:CellularComponent	respirasome	The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.		hp.json	membrane electron transport chain|respiratory chain	http://purl.obolibrary.org/obo/GO_0070469		
UBERON:0003368	biolink:AnatomicalEntity	epithelium of hard palate	An epithelium that is part of a hard palate [Automatically generated definition].	EMAPA:18953	hp.json	hard palate epithelium|epithelial tissue of hard palate|hard palate epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003368		
CHEBI:48927	biolink:ChemicalSubstance	N-acyl-L-alpha-amino acid	Any L-alpha-amino acid carrying an N-acyl substituent.	KEGG:C02850	hp.json	N-Acyl-L-amino acid	http://purl.obolibrary.org/obo/CHEBI_48927		3_STAR
UBERON:0003364	biolink:AnatomicalEntity	epithelium of right lung	An epithelium that is part of a right lung [Automatically generated definition].	EMAPA:17663|MA:0003132	hp.json	right lung epithelium|right lung epithelial tissue|epithelial tissue of right lung	http://purl.obolibrary.org/obo/UBERON_0003364		
UBERON:0003365	biolink:AnatomicalEntity	epithelium of left lung	An epithelium that is part of a left lung [Automatically generated definition].	EMAPA:17655|MA:0003131	hp.json	left lung epithelium|epithelial tissue of left lung|left lung epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003365		
UBERON:0003351	biolink:AnatomicalEntity	pharyngeal epithelium	An epithelium that is part of a pharynx [Automatically generated definition].	MA:0002725|XAO:0003202|BTO:0005240|RETIRED_EHDAA2:0001460|EMAPA:16708|BSA:0000112|ZFA:0001174|TAO:0001174	hp.json	pharynx epithelial tissue|pharynx epithelium|epithelium of pharynx|epithelial tissue of pharynx	http://purl.obolibrary.org/obo/UBERON_0003351		vertebrate_core
UBERON:0003352	biolink:AnatomicalEntity	epithelium of midgut	An epithelium that is part of a midgut.	EHDAA2:0001195|EMAPA:16569|MA:0003205|BTO:0005053	hp.json	epithelial tissue of midgut|midgut epithelium|midgut epithelium|midgut epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003352		
UBERON:0003350	biolink:AnatomicalEntity	epithelium of mucosa	A layer of epithelial cells on the surface of the mucosa.	BTO:0003752	hp.json	lamina epithelialis mucosae|lamina epithelialis mucosa	http://purl.obolibrary.org/obo/UBERON_0003350		
UBERON:0015329	biolink:AnatomicalEntity	respiratory system basement membrane	A basement membrane of epithelium that is part of a respiratory system.	MA:0001815|EMAPA:37570	hp.json		http://purl.obolibrary.org/obo/UBERON_0015329		
UBERON:0003359	biolink:AnatomicalEntity	epithelium of submandibular gland	An epithelium that is part of a submandibular gland [Automatically generated definition].	BTO:0004557|EMAPA:18813|VHOG:0000989	hp.json	submandibular duct epithelium|submandibular gland epithelial tissue|submaxillary gland epithelium|submandibular gland epithelium|epithelial tissue of submandibular gland|submandibular gland duct epithelium	http://purl.obolibrary.org/obo/UBERON_0003359		
UBERON:0003357	biolink:AnatomicalEntity	epithelium of tongue	An epithelium that is part of a tongue [Automatically generated definition].	BTO:0000992|NCIT:C49300|UMLS:C1710436|EMAPA:17881|FMA:284658|CALOHA:TS-1051|EHDAA2:0004598|MA:0001592	hp.json	lingual epithelium|tongue epithelium|tongue epithelial tissue|epithelial tissue of tongue	http://purl.obolibrary.org/obo/UBERON_0003357		pheno_slim
UBERON:0003358	biolink:AnatomicalEntity	epithelium of soft palate	An epithelium that is part of a soft palate [Automatically generated definition].	EMAPA:18950	hp.json	soft palate epithelial tissue|soft palate epithelium|epithelial tissue of soft palate	http://purl.obolibrary.org/obo/UBERON_0003358		
UBERON:0003355	biolink:AnatomicalEntity	epithelium of incisor	An epithelium that is part of a incisor tooth [Automatically generated definition].	EMAPA:32890|MA:0003223	hp.json	incisor epithelial tissue|incisor tooth epithelium|epithelium of incisor tooth|epithelial tissue of incisor tooth|incisor epithelium|incisor tooth epithelial tissue|epithelial tissue of incisor	http://purl.obolibrary.org/obo/UBERON_0003355		
UBERON:0003356	biolink:AnatomicalEntity	epithelium of nasal septum	An epithelium that is part of a nasal septum [Automatically generated definition].	EMAPA:18442	hp.json	epithelial tissue of nasal septum|nasal septum epithelium|nasal septum epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003356		
UBERON:0003353	biolink:AnatomicalEntity	epithelium of hindgut	An epithelium that is part of a hindgut [Automatically generated definition].	MA:0003206|EHDAA2:0000782|EMAPA:16717	hp.json	epithelial tissue of hindgut|hindgut epithelium|hindgut epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003353		
UBERON:0003354	biolink:AnatomicalEntity	epithelium of rectum	An epithelium that is part of a rectum [Automatically generated definition].	VHOG:0001037|EMAPA:17898|MA:0003219|FMA:17510|CALOHA:TS-2066|EHDAA2:0001594	hp.json	epithelial tissue of rectum|rectal epithelium|rectum epithelium|rectum epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0003354		
UBERON:0003339	biolink:AnatomicalEntity	ganglion of central nervous system	A ganglion that is part of a central nervous system [Automatically generated definition].	EMAPA:16658|EHDAA2:0000227|FMA:83843	hp.json	neuraxis ganglion|central nervous system ganglion|ganglion of neuraxis	http://purl.obolibrary.org/obo/UBERON_0003339		
UBERON:0003346	biolink:AnatomicalEntity	mucosa of rectum	A mucosa that is part of a rectum [Automatically generated definition].	SCTID:362167003|CALOHA:TS-2107|EMAPA:27081|MA:0003218|FMA:15033	hp.json	rectal mucosa|organ mucosa of rectum|mucous membrane of rectum|rectum mucosa|rectum organ mucosa|rectal mucous membrane|rectum mucosa of organ|rectum mucous membrane|mucosa of organ of rectum	http://purl.obolibrary.org/obo/UBERON_0003346		
UBERON:0003342	biolink:AnatomicalEntity	mucosa of anal canal	A mucosa that is part of an anal canal [Automatically generated definition].	UMLS:C0227414|NCIT:C60784|EMAPA:27531|SCTID:362170004|FMA:74654	hp.json	mucous membrane of anatomical anal canal|anal region mucosa|anatomical anal canal mucosa of organ|organ mucosa of anatomical anal canal|anal region organ mucosa|anal canal viewed anatomically mucosa of organ|mucosa of anatomical anal canal|anal canal mucous membrane|anal canal viewed anatomically mucosa|anal mucosa|anal canal viewed anatomically organ mucosa|anal mucous membrane|mucous membrane of anal region|mucosa of organ of anal canal|anatomical anal canal mucosa|anal region mucosa of organ|organ mucosa of anal region|mucosa of anal region|mucosa of organ of anatomical anal canal|anatomical anal canal organ mucosa|anatomical anal canal mucous membrane|anal canal viewed anatomically mucous membrane|anal canal mucosa|anal canal organ mucosa|mucosa of organ of anal canal viewed anatomically|mucosa of organ of anal region|organ mucosa of anal canal|mucous membrane of anal canal|anal region mucous membrane|mucosa of anal canal viewed anatomically|anal canal mucosa of organ|mucous membrane of anal canal viewed anatomically|organ mucosa of anal canal viewed anatomically	http://purl.obolibrary.org/obo/UBERON_0003342		human_reference_atlas
UBERON:0003343	biolink:AnatomicalEntity	mucosa of oral region	A mucosa that is part of a oral opening [Automatically generated definition].	SCTID:362083000|EMAPA:26937	hp.json	oral region mucous membrane|oral part of face mucosa|mucosa of organ of oral region|oral opening mucous membrane|subdivision of mouth mucosa of organ|oral part of face organ mucosa|mucosa of organ of oral opening|subdivision of mouth mucous membrane|subdivision of mouth mucosa|oral part of face mucosa of organ|mucosa of oral opening|organ mucosa of oral part of face|mucous membrane of oral part of face|mucous membrane of oral opening|subdivision of mouth organ mucosa|mucosa of organ of subdivision of mouth|organ mucosa of oral opening|mucosa of oral part of face|oral part of face mucous membrane|organ mucosa of oral region|mucosa of subdivision of mouth|mucosa of organ of oral part of face|oral region mucosa|oral opening mucosa|mucous membrane of oral region|oral opening mucosa of organ|oral region mucosa of organ|mucous membrane of subdivision of mouth|oral region organ mucosa|organ mucosa of subdivision of mouth|oral opening organ mucosa	http://purl.obolibrary.org/obo/UBERON_0003343		
RO:0015006	biolink:NamedThing	different in magnitude relative to	q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.		hp.json		http://purl.obolibrary.org/obo/RO_0015006		
RO:0015007	biolink:NamedThing	increased in magnitude relative to	q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.		hp.json		http://purl.obolibrary.org/obo/RO_0015007		
RO:0015008	biolink:NamedThing	decreased in magnitude relative to	q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale.		hp.json		http://purl.obolibrary.org/obo/RO_0015008		
GO:0045634	biolink:BiologicalProcess	regulation of melanocyte differentiation	Any process that modulates the frequency, rate or extent of melanocyte differentiation.		hp.json	regulation of melanophore differentiation	http://purl.obolibrary.org/obo/GO_0045634		
GO:0006023	biolink:BiologicalProcess	aminoglycan biosynthetic process	The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.		hp.json	aminoglycan anabolism|aminoglycan biosynthesis|aminoglycan synthesis|aminoglycan formation	http://purl.obolibrary.org/obo/GO_0006023		
GO:0006024	biolink:BiologicalProcess	glycosaminoglycan biosynthetic process	The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.		hp.json	glycosaminoglycan formation|glycosaminoglycan biosynthesis|glycosaminoglycan anabolism|glycosaminoglycan synthesis	http://purl.obolibrary.org/obo/GO_0006024		
GO:0006022	biolink:BiologicalProcess	aminoglycan metabolic process	The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages.		hp.json	aminoglycan metabolism	http://purl.obolibrary.org/obo/GO_0006022		
GO:0045639	biolink:BiologicalProcess	positive regulation of myeloid cell differentiation	Any process that activates or increases the frequency, rate or extent of myeloid cell differentiation.		hp.json	up-regulation of myeloid cell differentiation|activation of myeloid cell differentiation|upregulation of myeloid cell differentiation|up regulation of myeloid cell differentiation|stimulation of myeloid cell differentiation	http://purl.obolibrary.org/obo/GO_0045639		
GO:0045637	biolink:BiologicalProcess	regulation of myeloid cell differentiation	Any process that modulates the frequency, rate or extent of myeloid cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0045637		
GO:0045638	biolink:BiologicalProcess	negative regulation of myeloid cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.		hp.json	downregulation of myeloid cell differentiation|down regulation of myeloid cell differentiation|inhibition of myeloid cell differentiation|down-regulation of myeloid cell differentiation	http://purl.obolibrary.org/obo/GO_0045638		
GO:0045635	biolink:BiologicalProcess	negative regulation of melanocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of melanocyte differentiation.		hp.json	negative regulation of melanophore differentiation|downregulation of melanocyte differentiation|down regulation of melanocyte differentiation|inhibition of melanocyte differentiation|down-regulation of melanocyte differentiation	http://purl.obolibrary.org/obo/GO_0045635		
GO:0045636	biolink:BiologicalProcess	positive regulation of melanocyte differentiation	Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.		hp.json	stimulation of melanocyte differentiation|up regulation of melanocyte differentiation|up-regulation of melanocyte differentiation|activation of melanocyte differentiation|upregulation of melanocyte differentiation|positive regulation of melanophore differentiation	http://purl.obolibrary.org/obo/GO_0045636		
RO:0015011	biolink:NamedThing	has cross section	s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2.		hp.json		http://purl.obolibrary.org/obo/RO_0015011		
RO:0015012	biolink:NamedThing	reciprocal of	q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e.		hp.json		http://purl.obolibrary.org/obo/RO_0015012		
HP:3000001	biolink:PhenotypicFeature	obsolete Abnormal heart morphology			hp.json		http://purl.obolibrary.org/obo/HP_3000001		
HP:3000002	biolink:PhenotypicFeature	Abnormal inner ear epithelium morphology	Any structural anomaly of an inner ear epithelium.	UMLS:C4073211	hp.json		http://purl.obolibrary.org/obo/HP_3000002		
HP:3000003	biolink:PhenotypicFeature	Abnormal mandibular ramus morphology	An abnormality of a mandibular ramus.	UMLS:C4073212	hp.json	Abnormality of mandibular ramus	http://purl.obolibrary.org/obo/HP_3000003		
GO:0021654	biolink:BiologicalProcess	rhombomere boundary formation	The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.		hp.json		http://purl.obolibrary.org/obo/GO_0021654		
GO:0045648	biolink:BiologicalProcess	positive regulation of erythrocyte differentiation	Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.		hp.json	up regulation of erythrocyte differentiation|activation of erythrocyte differentiation|positive regulation of RBC differentiation|stimulation of erythrocyte differentiation|upregulation of erythrocyte differentiation|positive regulation of red blood cell differentiation|up-regulation of erythrocyte differentiation	http://purl.obolibrary.org/obo/GO_0045648		
GO:0045649	biolink:BiologicalProcess	regulation of macrophage differentiation	Any process that modulates the frequency, rate or extent of macrophage differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0045649		
GO:0045646	biolink:BiologicalProcess	regulation of erythrocyte differentiation	Any process that modulates the frequency, rate or extent of erythrocyte differentiation.		hp.json	regulation of red blood cell differentiation|regulation of RBC differentiation	http://purl.obolibrary.org/obo/GO_0045646		
GO:0045647	biolink:BiologicalProcess	negative regulation of erythrocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.		hp.json	negative regulation of red blood cell differentiation|negative regulation of RBC differentiation|down-regulation of erythrocyte differentiation|down regulation of erythrocyte differentiation|inhibition of erythrocyte differentiation|downregulation of erythrocyte differentiation	http://purl.obolibrary.org/obo/GO_0045647		
HP:3000008	biolink:PhenotypicFeature	Abnormality of mylohyoid muscle	An abnormality of a mylohyoid muscle.	UMLS:C4073217	hp.json		http://purl.obolibrary.org/obo/HP_3000008		
HP:3000009	biolink:PhenotypicFeature	Abnormality of nasalis muscle	An abnormality of a nasalis muscle.	UMLS:C4073218	hp.json		http://purl.obolibrary.org/obo/HP_3000009		
HP:3000004	biolink:PhenotypicFeature	Abnormality of frontalis muscle belly	An abnormality of a frontalis muscle belly.	UMLS:C4073213	hp.json		http://purl.obolibrary.org/obo/HP_3000004		
HP:3000005	biolink:PhenotypicFeature	Abnormality of masseter muscle	An abnormality of a masseter muscle.	UMLS:C4073214	hp.json		http://purl.obolibrary.org/obo/HP_3000005		
HP:3000006	biolink:PhenotypicFeature	Abnormality of medial pterygoid muscle	An abnormality of a medial pterygoid muscle.	UMLS:C4073215	hp.json		http://purl.obolibrary.org/obo/HP_3000006		
HP:3000007	biolink:PhenotypicFeature	Abnormality of mentalis muscle	An abnormality of a mentalis muscle.	UMLS:C4073216	hp.json		http://purl.obolibrary.org/obo/HP_3000007		
HP:3000011	biolink:PhenotypicFeature	Abnormality of palatoglossus muscle	An abnormality of a palatoglossus muscle.	UMLS:C4073220	hp.json		http://purl.obolibrary.org/obo/HP_3000011		
HP:3000012	biolink:PhenotypicFeature	Abnormality of palatopharyngeus muscle	An abnormality of a palatopharyngeus muscle.	UMLS:C4073221	hp.json		http://purl.obolibrary.org/obo/HP_3000012		
HP:3000013	biolink:PhenotypicFeature	Abnormal platysma muscle morphology	An abnormality of the platysma muscle.	UMLS:C4073222	hp.json	Abnormality of the platysma muscle|Abnormality of platysma	http://purl.obolibrary.org/obo/HP_3000013		
HP:3000014	biolink:PhenotypicFeature	Abnormality of procerus muscle	An abnormality of a procerus.	UMLS:C4073223	hp.json		http://purl.obolibrary.org/obo/HP_3000014		
HP:3000010	biolink:PhenotypicFeature	Abnormality of orbicularis oris muscle	An abnormality of an orbicularis oris muscle.	UMLS:C4073219	hp.json		http://purl.obolibrary.org/obo/HP_3000010		
GO:0006006	biolink:BiologicalProcess	glucose metabolic process	The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.		hp.json	cellular glucose metabolic process|glucose metabolism	http://purl.obolibrary.org/obo/GO_0006006		
GO:0021643	biolink:BiologicalProcess	vagus nerve maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.		hp.json	CN X maturation	http://purl.obolibrary.org/obo/GO_0021643		
GO:0045655	biolink:BiologicalProcess	regulation of monocyte differentiation	Any process that modulates the frequency, rate or extent of monocyte differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0045655		
GO:0045656	biolink:BiologicalProcess	negative regulation of monocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation.		hp.json	down regulation of monocyte differentiation|inhibition of monocyte differentiation|down-regulation of monocyte differentiation|downregulation of monocyte differentiation	http://purl.obolibrary.org/obo/GO_0045656		
RO:0003001	biolink:NamedThing	produced by	a produced_by b iff some process that occurs_in b has_output a.	RO:0003001	hp.json		http://purl.obolibrary.org/obo/RO_0003001		ro-eco
GO:0045653	biolink:BiologicalProcess	negative regulation of megakaryocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of megakaryocyte differentiation.		hp.json	down-regulation of megakaryocyte differentiation|down regulation of megakaryocyte differentiation|inhibition of megakaryocyte differentiation|downregulation of megakaryocyte differentiation	http://purl.obolibrary.org/obo/GO_0045653		
GO:0045654	biolink:BiologicalProcess	positive regulation of megakaryocyte differentiation	Any process that activates or increases the frequency, rate or extent of megakaryocyte differentiation.		hp.json	stimulation of megakaryocyte differentiation|upregulation of megakaryocyte differentiation|up-regulation of megakaryocyte differentiation|up regulation of megakaryocyte differentiation|activation of megakaryocyte differentiation	http://purl.obolibrary.org/obo/GO_0045654		
GO:0045651	biolink:BiologicalProcess	positive regulation of macrophage differentiation	Any process that activates or increases the frequency, rate or extent of macrophage differentiation.		hp.json	upregulation of macrophage differentiation|up regulation of macrophage differentiation|stimulation of macrophage differentiation|up-regulation of macrophage differentiation|activation of macrophage differentiation	http://purl.obolibrary.org/obo/GO_0045651		
GO:0045652	biolink:BiologicalProcess	regulation of megakaryocyte differentiation	Any process that modulates the frequency, rate or extent of megakaryocyte differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0045652		
GO:0006000	biolink:BiologicalProcess	fructose metabolic process	The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey.	Wikipedia:Fructose	hp.json	fructose metabolism	http://purl.obolibrary.org/obo/GO_0006000		
RO:0003000	biolink:NamedThing	produces	a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix.	RO:0003000	hp.json		http://purl.obolibrary.org/obo/RO_0003000		ro-eco
GO:0045650	biolink:BiologicalProcess	negative regulation of macrophage differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.		hp.json	downregulation of macrophage differentiation|down regulation of macrophage differentiation|inhibition of macrophage differentiation|down-regulation of macrophage differentiation	http://purl.obolibrary.org/obo/GO_0045650		
GO:0045659	biolink:BiologicalProcess	negative regulation of neutrophil differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of neutrophil differentiation.		hp.json	down-regulation of neutrophil differentiation|downregulation of neutrophil differentiation|down regulation of neutrophil differentiation|inhibition of neutrophil differentiation	http://purl.obolibrary.org/obo/GO_0045659		
GO:0045657	biolink:BiologicalProcess	positive regulation of monocyte differentiation	Any process that activates or increases the frequency, rate or extent of monocyte differentiation.		hp.json	upregulation of monocyte differentiation|up regulation of monocyte differentiation|stimulation of monocyte differentiation|up-regulation of monocyte differentiation|activation of monocyte differentiation	http://purl.obolibrary.org/obo/GO_0045657		
GO:0045658	biolink:BiologicalProcess	regulation of neutrophil differentiation	Any process that modulates the frequency, rate or extent of neutrophil differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0045658		
HP:3000019	biolink:PhenotypicFeature	Abnormal buccal mucosa morphology	An abnormality of a buccal mucosa.	UMLS:C4073228	hp.json	Abnormality of buccal mucosa|Abnormality of cheek mucosa|Abnormality of inside lining of cheek	http://purl.obolibrary.org/obo/HP_3000019		
GO:0021644	biolink:BiologicalProcess	vagus nerve morphogenesis	The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.		hp.json	CN X morphogenesis	http://purl.obolibrary.org/obo/GO_0021644		
GO:0021646	biolink:BiologicalProcess	vagus nerve formation	The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.		hp.json	CN X biosynthesis|CN X formation	http://purl.obolibrary.org/obo/GO_0021646		
HP:3000015	biolink:PhenotypicFeature	Abnormality of risorius muscle	An abnormality of a risorius muscle.	UMLS:C4073224	hp.json		http://purl.obolibrary.org/obo/HP_3000015		
HP:3000016	biolink:PhenotypicFeature	Abnormality of styloglossus muscle	An abnormality of the styloglossus muscle.	UMLS:C4073225	hp.json		http://purl.obolibrary.org/obo/HP_3000016		
HP:3000017	biolink:PhenotypicFeature	Abnormality of temporalis muscle	An abnormality of a temporalis muscle.	UMLS:C4073226	hp.json		http://purl.obolibrary.org/obo/HP_3000017		
HP:3000018	biolink:PhenotypicFeature	Abnormality of zygomaticus major muscle	An abnormality of a zygomaticus major muscle.	UMLS:C4073227	hp.json		http://purl.obolibrary.org/obo/HP_3000018		
HP:3000022	biolink:PhenotypicFeature	Abnormality of cartilage of external ear	An abnormality of a cartilage of external ear.	UMLS:C4073231	hp.json		http://purl.obolibrary.org/obo/HP_3000022		
CHEBI:22299	biolink:ChemicalSubstance	aldonate	A monocarboxylic acid anion resulting from the deprotonation of the carboxy group of an aldonic acid.		hp.json	aldonates|aldonate	http://purl.obolibrary.org/obo/CHEBI_22299		3_STAR
HP:3000023	biolink:PhenotypicFeature	Abnormality of angular artery	An abnormality of the angular artery, the terminal branch of the facial artery.	UMLS:C4073232	hp.json		http://purl.obolibrary.org/obo/HP_3000023		
HP:3000024	biolink:PhenotypicFeature	Abnormal facial artery morphology	Any structural abnormality of a facial artery, one of the branches of the external carotid artery.	UMLS:C4073233	hp.json	Abnormality of facial artery	http://purl.obolibrary.org/obo/HP_3000024		
HP:3000025	biolink:PhenotypicFeature	Abnormality of ciliary ganglion	An abnormality of a ciliary ganglion.	UMLS:C4073234	hp.json		http://purl.obolibrary.org/obo/HP_3000025		
HP:3000020	biolink:PhenotypicFeature	Abnormality of zygomaticus minor muscle	An abnormality of a zygomaticus minor muscle.	UMLS:C4073229	hp.json		http://purl.obolibrary.org/obo/HP_3000020		
HP:3000021	biolink:PhenotypicFeature	Abnormal buccal fat pad morphology	An abnormality of a buccal fat pad.	UMLS:C4073230	hp.json	Abnormality of buccal fat pad	http://purl.obolibrary.org/obo/HP_3000021		
GO:0045666	biolink:BiologicalProcess	positive regulation of neuron differentiation	Any process that activates or increases the frequency, rate or extent of neuron differentiation.		hp.json	up-regulation of neuron differentiation|activation of neuron differentiation|upregulation of neuron differentiation|up regulation of neuron differentiation|stimulation of neuron differentiation	http://purl.obolibrary.org/obo/GO_0045666		
GO:0043005	biolink:CellularComponent	neuron projection	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.	NIF_Subcellular:sao867568886	hp.json	neuron protrusion|neurite|neuronal cell projection|nerve fiber|neuron process	http://purl.obolibrary.org/obo/GO_0043005		goslim_pir
GO:0006012	biolink:BiologicalProcess	galactose metabolic process	The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose.	Wikipedia:Galactose	hp.json	galactose metabolism	http://purl.obolibrary.org/obo/GO_0006012		
GO:0045664	biolink:BiologicalProcess	regulation of neuron differentiation	Any process that modulates the frequency, rate or extent of neuron differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0045664		
GO:0045665	biolink:BiologicalProcess	negative regulation of neuron differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.		hp.json	downregulation of neuron differentiation|down regulation of neuron differentiation|inhibition of neuron differentiation|down-regulation of neuron differentiation	http://purl.obolibrary.org/obo/GO_0045665		
GO:0045662	biolink:BiologicalProcess	negative regulation of myoblast differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.		hp.json	down regulation of myoblast differentiation|inhibition of myoblast differentiation|down-regulation of myoblast differentiation|downregulation of myoblast differentiation	http://purl.obolibrary.org/obo/GO_0045662		
GO:0045663	biolink:BiologicalProcess	positive regulation of myoblast differentiation	Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.		hp.json	upregulation of myoblast differentiation|stimulation of myoblast differentiation|up regulation of myoblast differentiation|activation of myoblast differentiation|up-regulation of myoblast differentiation	http://purl.obolibrary.org/obo/GO_0045663		
GO:0045660	biolink:BiologicalProcess	positive regulation of neutrophil differentiation	Any process that activates or increases the frequency, rate or extent of neutrophil differentiation.		hp.json	up regulation of neutrophil differentiation|stimulation of neutrophil differentiation|up-regulation of neutrophil differentiation|activation of neutrophil differentiation|upregulation of neutrophil differentiation	http://purl.obolibrary.org/obo/GO_0045660		
GO:0043001	biolink:BiologicalProcess	Golgi to plasma membrane protein transport	The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0043001		
GO:0045661	biolink:BiologicalProcess	regulation of myoblast differentiation	Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.		hp.json		http://purl.obolibrary.org/obo/GO_0045661		
GO:0043009	biolink:BiologicalProcess	chordate embryonic development	The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.		hp.json		http://purl.obolibrary.org/obo/GO_0043009		
GO:0021635	biolink:BiologicalProcess	trigeminal nerve maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.		hp.json	CN V maturation	http://purl.obolibrary.org/obo/GO_0021635		
GO:0021636	biolink:BiologicalProcess	trigeminal nerve morphogenesis	The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.		hp.json	CN V morphogenesis	http://purl.obolibrary.org/obo/GO_0021636		
HP:3000026	biolink:PhenotypicFeature	obsolete Abnormality of common carotid artery plus branches			hp.json		http://purl.obolibrary.org/obo/HP_3000026		
HP:3000027	biolink:PhenotypicFeature	Abnormality of buccinator muscle	An abnormality of a buccinator muscle.	UMLS:C4073236	hp.json		http://purl.obolibrary.org/obo/HP_3000027		
GO:0021638	biolink:BiologicalProcess	trigeminal nerve formation	The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.		hp.json	CN V biosynthesis|CN V formation	http://purl.obolibrary.org/obo/GO_0021638		
HP:3000028	biolink:PhenotypicFeature	Abnormality of depressor anguli oris muscle	An abnormality of a depressor anguli oris muscle.	UMLS:C4073237	hp.json		http://purl.obolibrary.org/obo/HP_3000028		
HP:3000029	biolink:PhenotypicFeature	Abnormality of depressor labii inferioris	An abnormality of a depressor labii inferioris.	UMLS:C4073238	hp.json	Abnormality of depressor labii inferioris muscle	http://purl.obolibrary.org/obo/HP_3000029		
HP:3000033	biolink:PhenotypicFeature	Abnormal nasopharyngeal adenoid morphology	Any abnormality of nasopharyngeal adenoids.	UMLS:C4073241	hp.json	Abnormality of nasopharyngeal adenoids|Abnormality of adenoids|Abnormality of nasopharyngeal tonsil|Abnormality of pharyngeal tonsil	http://purl.obolibrary.org/obo/HP_3000033		
HP:3000034	biolink:PhenotypicFeature	Abnormality nasal septum cartilage morphology	An abnormality of a cartilage of nasal septum.	UMLS:C4073242	hp.json	Malformation of cartilage of nasal septum|Deformity of cartilage of nasal septum|Abnormality of cartilage of nasal septum|Abnormality of cartilage of septum of nose|Anomaly of cartilage of nasal septum	http://purl.obolibrary.org/obo/HP_3000034		
GO:0045670	biolink:BiologicalProcess	regulation of osteoclast differentiation	Any process that modulates the frequency, rate or extent of osteoclast differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0045670		
UBERON:0003409	biolink:AnatomicalEntity	gland of tongue	Any of the mucous, serous, or mixed glands that empty their secretions onto the surface of the tongue.	EMAPA:25097	hp.json	tongue gland|lingual gland	http://purl.obolibrary.org/obo/UBERON_0003409		
HP:3000035	biolink:PhenotypicFeature	Abnormality of cervical plexus	Abnormality of the plexus of the ventral rami of the first four cervical spinal nerves which are located from C1 to C4 cervical segment in the neck.	UMLS:C4073243	hp.json		http://purl.obolibrary.org/obo/HP_3000035		
HP:3000036	biolink:PhenotypicFeature	Abnormal head blood vessel morphology	An abnormality of a blood vessel of the head, including branches of the arterial and venous systems of the head.	UMLS:C4073244	hp.json	Abnormality of head blood vessel|Abnormality of vasculature of head|Abnormality of blood vessel of head	http://purl.obolibrary.org/obo/HP_3000036		
GO:0033605	biolink:BiologicalProcess	positive regulation of catecholamine secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of a catecholamine.		hp.json	up-regulation of catecholamine secretion|up regulation of catecholamine secretion|activation of catecholamine secretion|stimulation of catecholamine secretion|upregulation of catecholamine secretion	http://purl.obolibrary.org/obo/GO_0033605		
UBERON:0003407	biolink:AnatomicalEntity	cartilage of nasal septum	A cartilage that is part of a nasal septum [Automatically generated definition].	FMA:59503|MA:0003138|EMAPA:25091	hp.json	septal nasal cartilage|nasal septum cartilage|cartilago septal nasi	http://purl.obolibrary.org/obo/UBERON_0003407		pheno_slim
GO:0033604	biolink:BiologicalProcess	negative regulation of catecholamine secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a catecholamine.		hp.json	down regulation of catecholamine secretion|inhibition of catecholamine secretion|downregulation of catecholamine secretion|down-regulation of catecholamine secretion	http://purl.obolibrary.org/obo/GO_0033604		
UBERON:0003408	biolink:AnatomicalEntity	gland of digestive tract	A gland that is part of a digestive tract [Automatically generated definition].	EMAPA:18815|MA:0003202	hp.json	lower gastrointestinal tract gland|gut gland|gland of lower gastrointestinal tract|gland of digestive tract|digestive tract gland	http://purl.obolibrary.org/obo/UBERON_0003408		
HP:3000030	biolink:PhenotypicFeature	Abnormal morphology of bony orbit of skull	An abnormality of an orbit of skull.	UMLS:C4073239	hp.json	Abnormality of bones of the orbit of the skull|Abnormality of the orbital bones of skull|Abnormality of the bony eye socket|Abnormality of bony orbit of skull	http://purl.obolibrary.org/obo/HP_3000030		
GO:0033603	biolink:BiologicalProcess	positive regulation of dopamine secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of dopamine.		hp.json	upregulation of dopamine secretion|up regulation of dopamine secretion|stimulation of dopamine secretion|up-regulation of dopamine secretion|activation of dopamine secretion	http://purl.obolibrary.org/obo/GO_0033603		
GO:0033602	biolink:BiologicalProcess	negative regulation of dopamine secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine.		hp.json	down regulation of dopamine secretion|inhibition of dopamine secretion|down-regulation of dopamine secretion|downregulation of dopamine secretion	http://purl.obolibrary.org/obo/GO_0033602		
HP:3000031	biolink:PhenotypicFeature	Abnormality of anterior ethmoidal artery	An abnormality of an anterior ethmoidal artery.	UMLS:C4073287	hp.json		http://purl.obolibrary.org/obo/HP_3000031		
GO:0021620	biolink:BiologicalProcess	hypoglossal nerve formation	The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.		hp.json	CN XII biosynthesis|CN XII formation	http://purl.obolibrary.org/obo/GO_0021620		
GO:0008645	biolink:BiologicalProcess	hexose transmembrane transport	The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule.		hp.json	hexose transport|low-affinity hexose transport|high-affinity hexose transport|hexose membrane transport	http://purl.obolibrary.org/obo/GO_0008645		
HP:3000032	biolink:PhenotypicFeature	Abnormality of central retinal artery	An abnormality of a central retinal artery.	UMLS:C4073240	hp.json		http://purl.obolibrary.org/obo/HP_3000032		
UBERON:0003406	biolink:AnatomicalEntity	cartilage of respiratory system	A cartilage element that is part of a respiratory system [Automatically generated definition].	EMAPA:18694|MA:0001818	hp.json	respiratory system cartilage|apparatus respiratorius cartilage|cartilage of apparatus respiratorius	http://purl.obolibrary.org/obo/UBERON_0003406		
HP:0030374	biolink:PhenotypicFeature	Decreased proportion of memory B cells	A reduction in the normal proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).	UMLS:C4072913	hp.json		http://purl.obolibrary.org/obo/HP_0030374		
GO:0008643	biolink:BiologicalProcess	carbohydrate transport	The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.		hp.json	sugar transport	http://purl.obolibrary.org/obo/GO_0008643		goslim_yeast|goslim_pir
HP:0030375	biolink:PhenotypicFeature	Increased proportion of memory B cells	An elevation in the proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).	UMLS:C4072914	hp.json		http://purl.obolibrary.org/obo/HP_0030375		
HP:0030376	biolink:PhenotypicFeature	Abnormal proportion of immature B cells	A deviation from normal proportion of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+).	UMLS:C4072915	hp.json	Abnormal proportion of CD19+/CD21low B cells	http://purl.obolibrary.org/obo/HP_0030376		
HP:0030377	biolink:PhenotypicFeature	Increased proportion of immature B cells	An elevation in the proportion above normal of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+).	UMLS:C4072916	hp.json	Increased proportion of CD19+/CD21low B cells	http://purl.obolibrary.org/obo/HP_0030377		
GO:0043010	biolink:BiologicalProcess	camera-type eye development	The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.		hp.json		http://purl.obolibrary.org/obo/GO_0043010		
HP:0030370	biolink:PhenotypicFeature	Abnormal proportion of naive B cells	A deviation in the normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to the total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen.	UMLS:C4072909	hp.json		http://purl.obolibrary.org/obo/HP_0030370		
HP:0030371	biolink:PhenotypicFeature	Increased proportion of naive B cells	An elevation above the normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen.	UMLS:C4072910	hp.json		http://purl.obolibrary.org/obo/HP_0030371		
GO:0045671	biolink:BiologicalProcess	negative regulation of osteoclast differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of osteoclast differentiation.		hp.json	downregulation of osteoclast differentiation|down regulation of osteoclast differentiation|inhibition of osteoclast differentiation|down-regulation of osteoclast differentiation	http://purl.obolibrary.org/obo/GO_0045671		
HP:0030372	biolink:PhenotypicFeature	Decreased proportion of naive B cells	A reduction below normal proportion of naive B cells (CD19+/CD27-/IgD+/IgM+) relative to total number of B cells. Naive B cells represent one of the subtypes of B cells in the peripheral blood, and are B cells that have not been exposed to antigen.	UMLS:C4072911	hp.json		http://purl.obolibrary.org/obo/HP_0030372		
GO:0045672	biolink:BiologicalProcess	positive regulation of osteoclast differentiation	Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.		hp.json	up-regulation of osteoclast differentiation|activation of osteoclast differentiation|upregulation of osteoclast differentiation|up regulation of osteoclast differentiation|stimulation of osteoclast differentiation	http://purl.obolibrary.org/obo/GO_0045672		
HP:0030373	biolink:PhenotypicFeature	Abnormal proportion of memory B cells	A deviation of the normal proportion of memory B cells in circulation relative to total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).	UMLS:C4072912	hp.json		http://purl.obolibrary.org/obo/HP_0030373		
GO:0043011	biolink:BiologicalProcess	myeloid dendritic cell differentiation	The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.	Wikipedia:Dendritic_cell	hp.json		http://purl.obolibrary.org/obo/GO_0043011		
HP:0030378	biolink:PhenotypicFeature	Decreased proportion of immature B cells	A reduction in normal proportion of immature B cells (CD19+/ CD21low)in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+).	UMLS:C4072917	hp.json	Decreased proportion of CD19+/CD21low B cells	http://purl.obolibrary.org/obo/HP_0030378		
HP:0030379	biolink:PhenotypicFeature	Abnormal proportion of transitional B cells	A deviation in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells.	UMLS:C4072918	hp.json	Abnormal proportion of CD19+CD38+IgM+ cells	http://purl.obolibrary.org/obo/HP_0030379		
GO:0070633	biolink:BiologicalProcess	transepithelial transport	The directed movement of a substance from one side of an epithelium to the other.		hp.json		http://purl.obolibrary.org/obo/GO_0070633		
UBERON:0003414	biolink:AnatomicalEntity	mesenchyme of mandible	Mesenchyme that is part of a developing mandible [Automatically generated definition].	EMAPA:17912	hp.json	mesenchyme of ventral mandibular arch bone|mesenchyme of bone organ of lower jaw|bone of ventral mandibular arch mesenchyme|mesenchyme of mandibulla|mandible mesenchyme|mandibulla mesenchyme|ventral mandibular arch bone mesenchyme|ventral mandibular arch bone organ mesenchyme|mesenchyme of bone of ventral mandibular arch|mesenchyme of lower jaw bone organ|bone organ of lower jaw mesenchyme|lower jaw bone mesenchyme|lower jaw bone organ mesenchyme|mesenchyme of lower jaw bone|mesenchyme of bone organ of ventral mandibular arch|bone of lower jaw mesenchyme|mesenchyme of ventral mandibular arch bone organ|mesenchyme of bone of lower jaw|bone organ of ventral mandibular arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003414		
UBERON:0003415	biolink:AnatomicalEntity	mesenchyme of nasal septum	Mesenchyme that is part of a developing nasal septum [Automatically generated definition].	EMAPA:18443|FMA:312700	hp.json	nasal septum mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003415		
GO:0070634	biolink:BiologicalProcess	transepithelial ammonium transport	The directed movement of ammonium ions from one side of an epithelium to the other.		hp.json		http://purl.obolibrary.org/obo/GO_0070634		
UBERON:0003412	biolink:AnatomicalEntity	pelvic appendage bud mesenchyme	Mesenchyme that is part of a pelvic appendage bud.	ZFA:0001386|EMAPA:16781|TAO:0001386|EHDAA2:0001035	hp.json	lower limb bud mesenchyme|mesoderm pelvic fin bud|leg mesenchyme|pelvic fin bud mesenchyme|hindlimb bud mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003412		
UBERON:0003413	biolink:AnatomicalEntity	pectoral appendage bud mesenchyme	Mesenchyme that is part of a pectoral appendage bud.	TAO:0000789|EHDAA2:0002135|EMAPA:16408|ZFA:0000789|EHDAA:1703	hp.json	arm mesenchyme|mesoderm pectoral fin bud|forelimb bud mesenchyme|pectoral fin bud mesenchyme|upper limb bud mesenchyme|wing mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003413		
HP:3000037	biolink:PhenotypicFeature	Abnormal neck blood vessel morphology	An abnormality of a blood vessel of the neck, including branches of the arterial and venous systems of the neck.	UMLS:C4073245	hp.json	Abnormality of neck blood vessel|Abnormality of the cervical blood vessels|Abnormality of the cervical vasculature|Abnormality of the vasculature of the neck|Abnormality of blood vessel of neck	http://purl.obolibrary.org/obo/HP_3000037		
GO:0021626	biolink:BiologicalProcess	central nervous system maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.		hp.json		http://purl.obolibrary.org/obo/GO_0021626		
HP:3000038	biolink:PhenotypicFeature	Abnormal cricoid cartilage morphology	Any structural abnormality of a cricoid cartilage, that is, of the ring-shaped cartilage of the larynx.	UMLS:C4073246	hp.json	Abnormality of cricoid cartilage	http://purl.obolibrary.org/obo/HP_3000038		
HP:3000039	biolink:PhenotypicFeature	Abnormality of dorsal nasal artery	An abnormality of a dorsal nasal artery.	UMLS:C4073247	hp.json		http://purl.obolibrary.org/obo/HP_3000039		
HP:3000044	biolink:PhenotypicFeature	Abnormality of frontal process of maxilla	An abnormality of a frontal process of the maxilla bone.	UMLS:C4073252	hp.json		http://purl.obolibrary.org/obo/HP_3000044		
HP:3000045	biolink:PhenotypicFeature	Abnormality of genioglossus muscle	An abnormality of a genioglossus muscle.	UMLS:C4073253	hp.json		http://purl.obolibrary.org/obo/HP_3000045		
HP:3000046	biolink:PhenotypicFeature	Abnormal geniohyoid muscle morphology	An abnormality of a geniohyoid muscle.	UMLS:C4073254	hp.json		http://purl.obolibrary.org/obo/HP_3000046		
HP:0030380	biolink:PhenotypicFeature	Decreased proportion of transitional B cells	A reduction in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells.	UMLS:C4072919	hp.json	Decreased proportion of CD19+CD38+IgM+ cells	http://purl.obolibrary.org/obo/HP_0030380		
HP:3000047	biolink:PhenotypicFeature	Abnormal glossopharyngeal nerve morphology	Any structural anomaly of the glossopharyngeal nerve, the ninth paired cranial nerve (CN IX).	UMLS:C4073255	hp.json	Abnormality of glossopharyngeal nerve	http://purl.obolibrary.org/obo/HP_3000047		
HP:3000040	biolink:PhenotypicFeature	Abnormality of ethmoid sinus	An abnormality of an ethmoid sinus.	UMLS:C4073248	hp.json	Abnormality of ethmoidal air cells	http://purl.obolibrary.org/obo/HP_3000040		
GO:0055007	biolink:BiologicalProcess	cardiac muscle cell differentiation	The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.		hp.json	cardiomyocyte differentiation|heart muscle cell differentiation	http://purl.obolibrary.org/obo/GO_0055007		
HP:3000041	biolink:PhenotypicFeature	Abnormality of external carotid artery	An abnormality of an external carotid artery.	UMLS:C4073249	hp.json	Disorder of carotid artery|Abnormality of carotid artery	http://purl.obolibrary.org/obo/HP_3000041		
GO:0055008	biolink:BiologicalProcess	cardiac muscle tissue morphogenesis	The process in which the anatomical structures of cardiac muscle tissue are generated and organized.		hp.json	myocardium morphogenesis|heart muscle morphogenesis	http://purl.obolibrary.org/obo/GO_0055008		
HP:3000042	biolink:PhenotypicFeature	Abnormal jugular vein morphology	Any structural abnormality of a jugular vein.	UMLS:C4073250	hp.json	Abnormality of jugular vein	http://purl.obolibrary.org/obo/HP_3000042		
GO:0055009	biolink:BiologicalProcess	atrial cardiac muscle tissue morphogenesis	The process in which the anatomical structure of cardiac atrium muscle is generated and organized.		hp.json	cardiac atrium muscle morphogenesis|atrial heart muscle morphogenesis|atrial myocardium morphogenesis	http://purl.obolibrary.org/obo/GO_0055009		
HP:3000043	biolink:PhenotypicFeature	Abnormal facial vein morphology	An abnormality of a facial vein.	UMLS:C4073251	hp.json	Abnormality of facial vein|Abnormal vein of face	http://purl.obolibrary.org/obo/HP_3000043		
GO:0043025	biolink:CellularComponent	neuronal cell body	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.	NIF_Subcellular:sao1044911821|Wikipedia:Soma_(biology)	hp.json	neuronal cell soma|neuron cell body	http://purl.obolibrary.org/obo/GO_0043025		goslim_pir
HP:0030385	biolink:PhenotypicFeature	Increased proportion of marginal zone B cells	An elevation in the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells.	UMLS:C4072923	hp.json		http://purl.obolibrary.org/obo/HP_0030385		
HP:0030386	biolink:PhenotypicFeature	Abnormal proportion of class-switched memory B cells	A deviation of the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM-/IgD-) in circulation relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA.	UMLS:C4072924	hp.json	Abnormal proportion of CD19+CD27+IgD- cells	http://purl.obolibrary.org/obo/HP_0030386		
GO:0045686	biolink:BiologicalProcess	negative regulation of glial cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of glia cell differentiation.		hp.json	down regulation of glial cell differentiation|inhibition of glial cell differentiation|down-regulation of glial cell differentiation|negative regulation of neuroglia differentiation|downregulation of glial cell differentiation|negative regulation of glia cell differentiation	http://purl.obolibrary.org/obo/GO_0045686		
HP:0030387	biolink:PhenotypicFeature	Increased proportion of class-switched memory B cells	An increase in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA.	UMLS:C4073288	hp.json	Increased proportion of CD19+CD27+IgD- cells	http://purl.obolibrary.org/obo/HP_0030387		
HP:0030388	biolink:PhenotypicFeature	Decreased proportion of class-switched memory B cells	A reduction in the normal proportion of class-switched memory B cells (CD19+/CD27+/IgM+/IgD+) relative to the total number of B cells. Marginal zone B cells undergo limited somatic hypermutation and produce high-affinity IgM and some IgG, whereas class-switched memory B cells synthetize IgG, IgM, and IgA.	UMLS:C4072925	hp.json	Decreased proportion of CD19+CD27+IgD- cells	http://purl.obolibrary.org/obo/HP_0030388		
GO:0008652	biolink:BiologicalProcess	cellular amino acid biosynthetic process	The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.	Wikipedia:Amino_acid_synthesis	hp.json	cellular amino acid synthesis|cellular amino acid biosynthesis|cellular amino acid formation|cellular amino acid anabolism|amino acid biosynthetic process	http://purl.obolibrary.org/obo/GO_0008652		
GO:0045687	biolink:BiologicalProcess	positive regulation of glial cell differentiation	Any process that activates or increases the frequency, rate or extent of glia cell differentiation.		hp.json	upregulation of glial cell differentiation|positive regulation of neuroglia differentiation|up regulation of glial cell differentiation|stimulation of glial cell differentiation|positive regulation of glia cell differentiation|activation of glial cell differentiation|up-regulation of glial cell differentiation	http://purl.obolibrary.org/obo/GO_0045687		
GO:0043021	biolink:MolecularActivity	ribonucleoprotein complex binding	Binding to a complex of RNA and protein.		hp.json	protein-RNA complex binding|RNP binding|ribonucleoprotein binding	http://purl.obolibrary.org/obo/GO_0043021		goslim_pir
GO:0045684	biolink:BiologicalProcess	positive regulation of epidermis development	Any process that activates or increases the frequency, rate or extent of epidermis development.		hp.json	up regulation of epidermis development|positive regulation of epidermal development|activation of epidermis development|stimulation of epidermis development|upregulation of epidermis development|positive regulation of hypodermis development|up-regulation of epidermis development	http://purl.obolibrary.org/obo/GO_0045684		
HP:0030381	biolink:PhenotypicFeature	Increased proportion of transitional B cells	An elevation in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells.	UMLS:C4072920	hp.json	Increased proportion of CD19+CD38+IgM+ cells	http://purl.obolibrary.org/obo/HP_0030381		
GO:0045685	biolink:BiologicalProcess	regulation of glial cell differentiation	Any process that modulates the frequency, rate or extent of glia cell differentiation.		hp.json	regulation of neuroglia differentiation|regulation of glia cell differentiation	http://purl.obolibrary.org/obo/GO_0045685		
GO:0045682	biolink:BiologicalProcess	regulation of epidermis development	Any process that modulates the frequency, rate or extent of epidermis development.		hp.json	regulation of hypodermis development|regulation of epidermal development	http://purl.obolibrary.org/obo/GO_0045682		
HP:0030383	biolink:PhenotypicFeature	Abnormal proportion of marginal zone B cells	A deviation of the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells.	UMLS:C4072921	hp.json		http://purl.obolibrary.org/obo/HP_0030383		
GO:0043022	biolink:MolecularActivity	ribosome binding	Binding to a ribosome.		hp.json	ribosome receptor activity	http://purl.obolibrary.org/obo/GO_0043022		
GO:0045683	biolink:BiologicalProcess	negative regulation of epidermis development	Any process that stops, prevents, or reduces the frequency, rate or extent of epidermis development.		hp.json	negative regulation of epidermal development|negative regulation of hypodermis development|down-regulation of epidermis development|down regulation of epidermis development|inhibition of epidermis development|downregulation of epidermis development	http://purl.obolibrary.org/obo/GO_0045683		
HP:0030384	biolink:PhenotypicFeature	Decreased proportion of marginal zone B cells	A reduction in the normal proportion of marginal zone B cells (CD19+/CD27+/IgM+/IgD+) in circulation relative to the total number of B cells.	UMLS:C4072922	hp.json		http://purl.obolibrary.org/obo/HP_0030384		
GO:0021619	biolink:BiologicalProcess	hypoglossal nerve maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.		hp.json	CN XII maturation	http://purl.obolibrary.org/obo/GO_0021619		
HP:0030389	biolink:PhenotypicFeature	Abnormal circulating thromboxane concentration	Any deivation from the normal concentration in the blood circulation of a thromboxane. Thromboxanes are derived from prostaglandin precursors in platelets, and stimulate aggregation of platelets and constriction of blood vessels.	UMLS:C4072926	hp.json		http://purl.obolibrary.org/obo/HP_0030389		
GO:0043029	biolink:BiologicalProcess	T cell homeostasis	The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.		hp.json	T-cell homeostasis|T lymphocyte homeostasis|T-lymphocyte homeostasis	http://purl.obolibrary.org/obo/GO_0043029		
UBERON:0003403	biolink:AnatomicalEntity	skin of forearm	A zone of skin that is part of a lower arm [Automatically generated definition].	MA:0000602|FMA:38265|EMAPA:18056	hp.json	forearm skin|skin of antebrachial region|lower arm skin|lower segment of arm skin|skin of zeugopod of arm|skin of lower arm|skin of lower segment of arm	http://purl.obolibrary.org/obo/UBERON_0003403		
GO:0055003	biolink:BiologicalProcess	cardiac myofibril assembly	The process whose specific outcome is the progression of the cardiac myofibril over time, from its formation to the mature structure. A cardiac myofibril is a myofibril specific to cardiac muscle cells.		hp.json	cardiac myofibril morphogenesis|heart myofibril assembly|cardiac myofibril development	http://purl.obolibrary.org/obo/GO_0055003		
GO:0021614	biolink:BiologicalProcess	glossopharyngeal nerve maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.		hp.json	CN IX maturation	http://purl.obolibrary.org/obo/GO_0021614		
GO:0055006	biolink:BiologicalProcess	cardiac cell development	The process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual.		hp.json	cardiocyte development|heart cell development	http://purl.obolibrary.org/obo/GO_0055006		
HP:3000048	biolink:PhenotypicFeature	Abnormal great auricular nerve morphology	Any structural anomaly of a great auricular nerve.	UMLS:C4073256	hp.json		http://purl.obolibrary.org/obo/HP_3000048		
GO:0021615	biolink:BiologicalProcess	glossopharyngeal nerve morphogenesis	The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.		hp.json	CN IX morphogenesis	http://purl.obolibrary.org/obo/GO_0021615		
HP:3000049	biolink:PhenotypicFeature	Abnormal greater palatine artery morphology	An abnormality of a greater palatine artery.	UMLS:C4073257	hp.json	Abnormality of greater palatine artery	http://purl.obolibrary.org/obo/HP_3000049		
GO:0021616	biolink:BiologicalProcess	glossopharyngeal nerve formation	The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.		hp.json	CN IX biosynthesis|CN IX formation	http://purl.obolibrary.org/obo/GO_0021616		
GO:0055001	biolink:BiologicalProcess	muscle cell development	The process whose specific outcome is the progression of a muscle cell over time, from its formation to the mature structure. Muscle cell development does not include the steps involved in committing an unspecified cell to the muscle cell fate.		hp.json	myofibre development|muscle fiber development|myofiber development|muscle fibre development	http://purl.obolibrary.org/obo/GO_0055001		
GO:0021618	biolink:BiologicalProcess	hypoglossal nerve morphogenesis	The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.		hp.json	CN XII morphogenesis	http://purl.obolibrary.org/obo/GO_0021618		
GO:0055002	biolink:BiologicalProcess	striated muscle cell development	The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.		hp.json		http://purl.obolibrary.org/obo/GO_0055002		
HP:3000055	biolink:PhenotypicFeature	Abnormality of inferior alveolar nerve	An abnormality of an inferior alveolar nerve.	UMLS:C4073263	hp.json		http://purl.obolibrary.org/obo/HP_3000055		
CHEBI:48873	biolink:ChemicalSubstance	cholinergic antagonist	Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.		hp.json	anticholinergic agents|agentes anticolinergicos|acetylcholine antagonists|agente anticolinergico|Anticholinergika|agent anticholinergique|acetylcholine receptor antagonist|Anticholinergikum|anticholinergiques|cholinergic-blocking agents|anticholinergics|anticolinergicos	http://purl.obolibrary.org/obo/CHEBI_48873		3_STAR
HP:3000056	biolink:PhenotypicFeature	Abnormality of artery of lower lip	An abnormality of an artery of lower lip.	UMLS:C4073264	hp.json	Abnormality of the inferior labial artery	http://purl.obolibrary.org/obo/HP_3000056		
HP:0030390	biolink:PhenotypicFeature	Reduced circulating leukotriene C4 concentration	An abnormally decreased concentration of leukotriene C4 in the blood circulation.	UMLS:C4072927	hp.json		http://purl.obolibrary.org/obo/HP_0030390		
GO:0043030	biolink:BiologicalProcess	regulation of macrophage activation	Any process that modulates the frequency or rate of macrophage activation.		hp.json	regulation of macrophage polarization	http://purl.obolibrary.org/obo/GO_0043030		
HP:3000057	biolink:PhenotypicFeature	Abnormality of inferior oblique extraocular muscle	An abnormality of an inferior oblique extraocular muscle.	UMLS:C4073265	hp.json	Abnormality of the inferior oblique muscle	http://purl.obolibrary.org/obo/HP_3000057		
HP:3000058	biolink:PhenotypicFeature	Abnormality of inferior rectus extraocular muscle	An abnormality of an inferior rectus extraocular muscle.	UMLS:C4073266	hp.json		http://purl.obolibrary.org/obo/HP_3000058		
HP:0030391	biolink:PhenotypicFeature	Spoken word recognition deficit	Reduced ability of lexical discrimination, which refers to the process of distinguishing a stimulus word from other phonologically similar words. Lexical discrimination can be defined as the process of correctly identifying words in the mental lexicon to match the phonological input of a stimulus.	UMLS:C4072928	hp.json		http://purl.obolibrary.org/obo/HP_0030391		
HP:3000051	biolink:PhenotypicFeature	Abnormal hyoglossus muscle morphology	An abnormality of a hyoglossus muscle.	UMLS:C4073259	hp.json	Abnormality of hyoglossus muscle	http://purl.obolibrary.org/obo/HP_3000051		
GO:0055018	biolink:BiologicalProcess	regulation of cardiac muscle fiber development	Any process that modulates the frequency, rate or extent of cardiac muscle fiber development.		hp.json	regulation of cardiac muscle fibre development|regulation of heart muscle fiber development	http://purl.obolibrary.org/obo/GO_0055018		
GO:0055019	biolink:BiologicalProcess	negative regulation of cardiac muscle fiber development	Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle fiber development.		hp.json	inhibition of cardiac muscle fiber development|negative regulation of heart muscle fiber development|down-regulation of cardiac muscle fiber development|downregulation of cardiac muscle fiber development|negative regulation of cardiac muscle fibre development|down regulation of cardiac muscle fiber development	http://purl.obolibrary.org/obo/GO_0055019		
HP:3000052	biolink:PhenotypicFeature	Abnormal hyoid bone morphology	Any structural abnormality of the hyoid bone (hyoid), a small U-shaped (horseshoe-shaped) solitary bone, situated in the midline of the neck anteriorly at the base of the mandible and posteriorly at the fourth cervical vertebra.	UMLS:C4073260	hp.json	Abnormality of hyoid bone	http://purl.obolibrary.org/obo/HP_3000052		
HP:3000053	biolink:PhenotypicFeature	Abnormal hypopharynx morphology	A structural anomaly of the hypopharyx, which is the most inferior portion of the pharynx. The hypopharynx continues from the oropharynx at the pharyngoepiglottic fold superiorly and extends inferiorly to the level of the inferior aspect of the cricoid cartilage, which marks the beginning of the cervical esophagus.	UMLS:C4073261	hp.json	Abnormality of lower pharynx|Abnormality of hypopharynx	http://purl.obolibrary.org/obo/HP_3000053		
HP:3000054	biolink:PhenotypicFeature	Abnormal inferior alveolar artery morphology	An abnormality of an inferior alveolar artery.	UMLS:C4073262	hp.json		http://purl.obolibrary.org/obo/HP_3000054		
HP:0030396	biolink:PhenotypicFeature	Abnormal platelet granule secretion	Platelets are replete with secretory granules, which are critical to normal platelet function. Among the three types of platelet secretory granules - alpha-granules, dense granules, and lysosomes - the alpha-granule is the most abundant. Granule contents must be released from their intracellular repository in order to achieve their physiologic function, and this term refers to a functional defect in granule secretion.	UMLS:C4072929	hp.json		http://purl.obolibrary.org/obo/HP_0030396		
HP:0030397	biolink:PhenotypicFeature	Abnormal platelet dense granule secretion	Abnormal release of dense granules from platelets.	UMLS:C4072930	hp.json		http://purl.obolibrary.org/obo/HP_0030397		
HP:0030398	biolink:PhenotypicFeature	Abnormal platelet ATP dense granule secretion	Abnormal secretion of the platelet dense-granule content adenosine triphosphate (ATP).	UMLS:C4072931	hp.json		http://purl.obolibrary.org/obo/HP_0030398		
HP:3000050	biolink:PhenotypicFeature	Abnormal odontoid tissue morphology	An abnormality of an odontoid tissue.	UMLS:C4073258	hp.json	Abnormality of odontoid tissue|Abnormality of hard tissues of teeth|Abnormality of tooth hard tissue	http://purl.obolibrary.org/obo/HP_3000050		
HP:0030399	biolink:PhenotypicFeature	Abnormal platelet alpha granule secretion	Abnormal release of alpha granule contents from platelets.	UMLS:C4072932	hp.json		http://purl.obolibrary.org/obo/HP_0030399		
GO:0043032	biolink:BiologicalProcess	positive regulation of macrophage activation	Any process that stimulates, induces or increases the rate of macrophage activation.		hp.json	up-regulation of macrophage activation|up regulation of macrophage activation|activation of macrophage activation|positive regulation of macrophage polarization|stimulation of macrophage activation|upregulation of macrophage activation	http://purl.obolibrary.org/obo/GO_0043032		
HP:0030392	biolink:PhenotypicFeature	Choroid plexus carcinoma	Intraventricular papillary neoplasm derived from choroid plexus epithelium. Plexus tumors are most common in the lateral and fourth ventricles; while 80% of lateral ventricle tumors present in children, fourth ventricle tumors are evenly distributed in all age groups. Clinically, choroid plexus tumors tend to cause hydrocephalus and increased intracranial pressure. Histologically, choroid plexus papillomas correspond to WHO grade I, choroid plexus carcinomas to WHO grade III.	MSH:C562943|UMLS:C0431109|SNOMEDCT_US:88252006	hp.json		http://purl.obolibrary.org/obo/HP_0030392		
HP:0030393	biolink:PhenotypicFeature	Endolymphatic sac tumor	A low-grade papillary epithelial neoplasm (adenocarcinoma) with a slow growth pattern. The endolymphatic duct emerges from the posterior wall of the saccule (of the inner ear) and ends in a blind pouch, the endolymphatic sac. Endolymphatic sac tumors (ELSTs) are known under different names in the literature (Heffner tumor, aggressive papillary middle ear tumor, and low-grade adenocarcinoma of endolymphatic sac origin).	UMLS:C2348239|SNOMEDCT_US:699817008	hp.json	Heffner tumor|Endolymphatic sac tumour|Aggressive papillary middle ear tumor|Aggressive papillary middle ear tumour|Low-grade adenocarcinoma of endolymphatic sac origin|Heffner tumour	http://purl.obolibrary.org/obo/HP_0030393		
GO:0043031	biolink:BiologicalProcess	negative regulation of macrophage activation	Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.		hp.json	inhibition of macrophage activation|downregulation of macrophage activation|negative regulation of macrophage polarization|down-regulation of macrophage activation|down regulation of macrophage activation	http://purl.obolibrary.org/obo/GO_0043031		
HP:0030394	biolink:PhenotypicFeature	Fallopian tube carcinoma	Carcinoma that originates in the Fallopian tube. It may be located in the wall or within the lumen as a growth attached to the wall by a stalk.	SNOMEDCT_US:276870001|MSH:D005185|UMLS:C0238122	hp.json		http://purl.obolibrary.org/obo/HP_0030394		
CHEBI:36885	biolink:ChemicalSubstance	20-oxo steroid	An oxo steroid carrying an oxo group at position 20.		hp.json	20-oxo steroids	http://purl.obolibrary.org/obo/CHEBI_36885		3_STAR
GO:0021608	biolink:BiologicalProcess	accessory nerve formation	The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.		hp.json	CN XI formation|CN XI biosynthesis	http://purl.obolibrary.org/obo/GO_0021608		
CHEBI:36887	biolink:ChemicalSubstance	18-oxo steroid			hp.json	18-oxo steroids	http://purl.obolibrary.org/obo/CHEBI_36887		3_STAR
GO:0021602	biolink:BiologicalProcess	cranial nerve morphogenesis	The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.		hp.json		http://purl.obolibrary.org/obo/GO_0021602		
GO:0055017	biolink:BiologicalProcess	cardiac muscle tissue growth	The increase in size or mass of a cardiac muscle, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.		hp.json	heart muscle growth	http://purl.obolibrary.org/obo/GO_0055017		
GO:0021603	biolink:BiologicalProcess	cranial nerve formation	The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.		hp.json		http://purl.obolibrary.org/obo/GO_0021603		
GO:0055010	biolink:BiologicalProcess	ventricular cardiac muscle tissue morphogenesis	The process in which the anatomical structures of cardiac ventricle muscle is generated and organized.		hp.json	cardiac ventricle muscle morphogenesis|ventricular heart muscle morphogenesis	http://purl.obolibrary.org/obo/GO_0055010		
HP:3000059	biolink:PhenotypicFeature	Abnormal inferior thyroid vein morphology	An abnormality of an inferior thyroid vein.	UMLS:C4073267	hp.json	Abnormality of inferior thyroid vein	http://purl.obolibrary.org/obo/HP_3000059		
GO:0021605	biolink:BiologicalProcess	cranial nerve maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.		hp.json		http://purl.obolibrary.org/obo/GO_0021605		
GO:0021606	biolink:BiologicalProcess	accessory nerve maturation	A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.		hp.json	CN XI maturation|spinal accessory nerve maturation	http://purl.obolibrary.org/obo/GO_0021606		
GO:0021607	biolink:BiologicalProcess	accessory nerve morphogenesis	The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.		hp.json	CN XI morphogenesis	http://purl.obolibrary.org/obo/GO_0021607		
GO:0055013	biolink:BiologicalProcess	cardiac muscle cell development	The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.		hp.json	cardiac muscle fibre development|heart muscle cell development|cardiac muscle fiber development|heart muscle fiber development|cardiomyocyte cell development	http://purl.obolibrary.org/obo/GO_0055013		
HP:3000066	biolink:PhenotypicFeature	Abnormal lacrimal sac morphology	An abnormality of a lacrimal sac.	UMLS:C4073273	hp.json	Abnormality of lacrimal sac	http://purl.obolibrary.org/obo/HP_3000066		
HP:3000067	biolink:PhenotypicFeature	Abnormal lateral cricoarytenoid muscle morphology	Any structural abnormality of a lateral crico-arytenoid muscle, which extends from the lateral cricoid cartilage to the muscular process of the arytenoid cartilage, and can adduct the vocal cords, which closes the rima glottidis and thereby protects the airway.	UMLS:C4073274	hp.json	Abnormal anterior cricoarytenoid muscle morphology|Abnormality of lateral cricoarytenoid muscle|Abnormality of lateral crico-arytenoid	http://purl.obolibrary.org/obo/HP_3000067		
HP:3000068	biolink:PhenotypicFeature	Abnormality of lateral pterygoid muscle	An abnormality of a lateral pterygoid muscle.	UMLS:C4073275	hp.json		http://purl.obolibrary.org/obo/HP_3000068		
HP:3000069	biolink:PhenotypicFeature	Abnormality of lateral rectus extra-ocular muscle	An abnormality of a lateral rectus extra-ocular muscle.	UMLS:C4073276	hp.json		http://purl.obolibrary.org/obo/HP_3000069		
HP:3000062	biolink:PhenotypicFeature	Abnormal internal carotid artery morphology	An abnormality of an internal carotid artery.	UMLS:C1860488	hp.json	Abnormality of internal carotid artery	http://purl.obolibrary.org/obo/HP_3000062		
HP:3000063	biolink:PhenotypicFeature	Abnormality of internal jugular vein	An abnormality of an internal jugular vein.	UMLS:C4073270	hp.json		http://purl.obolibrary.org/obo/HP_3000063		
HP:3000064	biolink:PhenotypicFeature	Abnormality of intrinsic muscle of tongue	An abnormality of an intrinsic muscle of tongue.	UMLS:C4073271	hp.json	Abnormality of intrinsic lingual muscle	http://purl.obolibrary.org/obo/HP_3000064		
HP:3000065	biolink:PhenotypicFeature	Abnormal lacrimal artery morphology	An abnormality of a lacrimal artery.	UMLS:C4073272	hp.json	Abnormality of lacrimal artery	http://purl.obolibrary.org/obo/HP_3000065		
HP:3000060	biolink:PhenotypicFeature	Abnormal infraorbital artery morphology	An abnormality of an infraorbital artery.	UMLS:C4073268	hp.json	Abnormality of infraorbital artery	http://purl.obolibrary.org/obo/HP_3000060		
HP:3000061	biolink:PhenotypicFeature	Abnormality of infra-orbital nerve	A structural abnormality of an infra-orbital nerve. The infraorbital nerve arises from the maxillary branch of the trigeminal nerve and normally traverses the orbital floor in the infraorbital canal.	UMLS:C4073269	hp.json	Abnormality of the infraorbital nerve	http://purl.obolibrary.org/obo/HP_3000061		
GO:0043043	biolink:BiologicalProcess	peptide biosynthetic process	The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide.		hp.json	peptide synthesis|peptide formation|peptide biosynthesis|peptide anabolism	http://purl.obolibrary.org/obo/GO_0043043		
GO:0055020	biolink:BiologicalProcess	positive regulation of cardiac muscle fiber development	Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle fiber development.		hp.json	up regulation of cardiac muscle fiber development|stimulation of cardiac muscle fiber development|up-regulation of cardiac muscle fiber development|activation of cardiac muscle fiber development|positive regulation of cardiac muscle fibre development|positive regulation of heart muscle fiber development|upregulation of cardiac muscle fiber development	http://purl.obolibrary.org/obo/GO_0055020		
GO:0055025	biolink:BiologicalProcess	positive regulation of cardiac muscle tissue development	Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle tissue development.		hp.json	up regulation of cardiac muscle development|stimulation of cardiac muscle development|up-regulation of cardiac muscle development|activation of cardiac muscle development|positive regulation of heart muscle development|upregulation of cardiac muscle development	http://purl.obolibrary.org/obo/GO_0055025		
GO:0055026	biolink:BiologicalProcess	negative regulation of cardiac muscle tissue development	Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development.		hp.json	downregulation of cardiac muscle development|negative regulation of heart muscle development|down regulation of cardiac muscle development|inhibition of cardiac muscle development|down-regulation of cardiac muscle development	http://purl.obolibrary.org/obo/GO_0055026		
GO:0055021	biolink:BiologicalProcess	regulation of cardiac muscle tissue growth	Any process that modulates the frequency, rate or extent of cardiac muscle growth.		hp.json		http://purl.obolibrary.org/obo/GO_0055021		
GO:0055022	biolink:BiologicalProcess	negative regulation of cardiac muscle tissue growth	Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle growth.		hp.json	down-regulation of cardiac muscle growth|down regulation of cardiac muscle growth|inhibition of cardiac muscle growth|downregulation of cardiac muscle growth|negative regulation of heart muscle growth	http://purl.obolibrary.org/obo/GO_0055022		
GO:0055023	biolink:BiologicalProcess	positive regulation of cardiac muscle tissue growth	Any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth.		hp.json	activation of cardiac muscle growth|stimulation of cardiac muscle growth|upregulation of cardiac muscle growth|positive regulation of heart muscle growth|up-regulation of cardiac muscle growth|up regulation of cardiac muscle growth	http://purl.obolibrary.org/obo/GO_0055023		
GO:0055024	biolink:BiologicalProcess	regulation of cardiac muscle tissue development	Any process that modulates the frequency, rate or extent of cardiac muscle tissue development.		hp.json	regulation of heart muscle development	http://purl.obolibrary.org/obo/GO_0055024		
HP:3000077	biolink:PhenotypicFeature	Abnormal mandible condylar process morphology	An abnormality of a mandible condylar process.	UMLS:C4073284	hp.json	Abnormality of mandible condylar process	http://purl.obolibrary.org/obo/HP_3000077		
HP:3000078	biolink:PhenotypicFeature	Abnormal mandible coronoid process morphology	An abnormality of a mandible coronoid process.	UMLS:C4073285	hp.json	Abnormality of mandible coronoid process	http://purl.obolibrary.org/obo/HP_3000078		
HP:3000079	biolink:PhenotypicFeature	Abnormal mandibular symphysis morphology	A structural abnormality of a mandibular symphysis.	UMLS:C4073286	hp.json	Abnormality of mandible symphysis	http://purl.obolibrary.org/obo/HP_3000079		
HP:3000073	biolink:PhenotypicFeature	Abnormality of levator veli palatini muscle	An abnormality of a levator veli palatini.	UMLS:C4073280	hp.json		http://purl.obolibrary.org/obo/HP_3000073		
HP:3000074	biolink:PhenotypicFeature	Abnormal lingual artery morphology	Any structural abnormality of a lingual artery.	UMLS:C4073281	hp.json	Abnormality of lingual artery	http://purl.obolibrary.org/obo/HP_3000074		
HP:3000075	biolink:PhenotypicFeature	Abnormal lingual nerve morphology	Any structural anomaly of a lingual nerve.	UMLS:C4073282	hp.json	Abnormality of lingual nerve	http://purl.obolibrary.org/obo/HP_3000075		
HP:3000076	biolink:PhenotypicFeature	Abnormality of lingual tonsil	An abnormality of a lingual tonsil.	UMLS:C4073283	hp.json		http://purl.obolibrary.org/obo/HP_3000076		
HP:0030330	biolink:PhenotypicFeature	Multinucleated giant chondrocytes in epiphyseal cartilage	The presence of cartilage cells (chondrocytes) that are substantially increased in size and contain more than one nucleus and are located within the resting zone of the epiphyseal cartilage.	UMLS:C4022506	hp.json		http://purl.obolibrary.org/obo/HP_0030330		
HP:0032993	biolink:PhenotypicFeature	Abnormal pulmonary fissure count	A deviation from the normal number of pulmonary fissures.		hp.json		http://purl.obolibrary.org/obo/HP_0032993		
HP:0030331	biolink:PhenotypicFeature	Impaired stimulus-induced skin wrinkling	A reduced ability of the skin of the fingertips to wrinkle when exposed to stimuli such as soaking in water or application of EMLA cream (the fingertip remains smooth).	UMLS:C4022505	hp.json		http://purl.obolibrary.org/obo/HP_0030331		
HP:3000070	biolink:PhenotypicFeature	Abnormality of levator anguli oris	An abnormality of a levator anguli oris.	UMLS:C4073277	hp.json		http://purl.obolibrary.org/obo/HP_3000070		
HP:0032992	biolink:PhenotypicFeature	Abnormal pulmonary fissure architecture	An abnormal form or location of a pulmonary fissure.		hp.json		http://purl.obolibrary.org/obo/HP_0032992		
HP:3000071	biolink:PhenotypicFeature	Abnormality of levator labii superioris	An abnormality of a levator labii superioris.	UMLS:C4073278	hp.json		http://purl.obolibrary.org/obo/HP_3000071		
HP:0032995	biolink:PhenotypicFeature	Decreased pulmonary fissure count	Lack of one or more of the normal pulmonary fissures.		hp.json	Reduced pulmonary fissure count	http://purl.obolibrary.org/obo/HP_0032995		
HP:0030332	biolink:PhenotypicFeature	obsolete Abnormal T cell morphology			hp.json		http://purl.obolibrary.org/obo/HP_0030332		
HP:0032994	biolink:PhenotypicFeature	Supernumerary pulmonary fissure	Presence of a lung fissure that does not exist normally. Supernumerary fissures include the superior accessory fissure, the medial basal fissure, the left horizontal fissure, and the azygos fissure form supernumerary lobes.		hp.json	increased pulmonary fissure count	http://purl.obolibrary.org/obo/HP_0032994		
HP:3000072	biolink:PhenotypicFeature	Abnormal levator palpebrae superioris morphology	An abnormality of a levator palpebrae superioris.	UMLS:C4073279	hp.json		http://purl.obolibrary.org/obo/HP_3000072		
HP:0030333	biolink:PhenotypicFeature	Abnormal alpha-beta T cell morphology	A structuraly anomaly of T cells that express an alpha-beta T cell receptor.	UMLS:C4022503	hp.json		http://purl.obolibrary.org/obo/HP_0030333		
HP:0032991	biolink:PhenotypicFeature	Abnormal pulmonary fissure morphology	An abnormal form or number of the pulmonary fissures.		hp.json		http://purl.obolibrary.org/obo/HP_0032991		
HP:0032990	biolink:PhenotypicFeature	Localized pulmonary hemorrhage	Circumscribed pulmonary hemorrhage originating from a single bleeding site in the lungs. This can be due to infections, tumorigenesis, foreign bodies, or vascular abnormalities. Patient often feel the site of bleeding, contrast CT scan or angiography may localize the bleeder.		hp.json	Localised pulmonary haemorrhage	http://purl.obolibrary.org/obo/HP_0032990		
HP:0030338	biolink:PhenotypicFeature	Abnormal circulating gonadotropin concentration	An anomaly of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH).	UMLS:C4072886	hp.json	Abnormal circulating gonadotropin level	http://purl.obolibrary.org/obo/HP_0030338		
HP:0030339	biolink:PhenotypicFeature	Decreased circulating gonadotropin concentration	A reduction of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH).	UMLS:C4072887	hp.json	Decreased circulating gonadotropin level	http://purl.obolibrary.org/obo/HP_0030339		
HP:0030334	biolink:PhenotypicFeature	Abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology	A structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell. These cells are regulatory T cells.	UMLS:C4022502	hp.json		http://purl.obolibrary.org/obo/HP_0030334		
HP:0032997	biolink:PhenotypicFeature	Decreased cystatin C level	A decreased concentration of cystatin C in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032997		
HP:0030335	biolink:PhenotypicFeature	Abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell count	A deviation from the normal count of CD4-positive, CD25-positive, alpha-beta regulatory T cells.	UMLS:C4021859	hp.json		http://purl.obolibrary.org/obo/HP_0030335		
HP:0005368	biolink:PhenotypicFeature	Abnormality of humoral immunity	An abnormality of the humoral immune system, which comprises antibodies produced by B cells as well as the complement system.	UMLS:C3150510	hp.json	Defective humoral immunity	http://purl.obolibrary.org/obo/HP_0005368		
HP:0032996	biolink:PhenotypicFeature	Abnormal cystatin C level	Any deviation from the normal concentration of cystatin C in serum or plasma.		hp.json		http://purl.obolibrary.org/obo/HP_0032996		
HP:0005369	biolink:PhenotypicFeature	Decreased serum complement factor H	A reduced level of the complement component Factor H in circulation.	UMLS:C1969222	hp.json		http://purl.obolibrary.org/obo/HP_0005369		
HP:0032999	biolink:PhenotypicFeature	Increased fecal porphyrin	Abnormally high concentration of fecal porphyrins in feces.		hp.json	Increased faecal porphyrin	http://purl.obolibrary.org/obo/HP_0032999		
HP:0030336	biolink:PhenotypicFeature	Absence of CD4-positive, CD25-positive regulatory T cells	Lack of CD4+CD25+ T regulatory cells.	UMLS:C4021039	hp.json	Absence of CD4+CD25+ T regulatory cells|Absence of CD4+CD25+ Tregs	http://purl.obolibrary.org/obo/HP_0030336		
HP:0030337	biolink:PhenotypicFeature	Elevated CD4-positive, CD25-positive regulatory T cell count	An increased number of CD4-positive, CD25-positive regulatory T cells.	UMLS:C4022501	hp.json		http://purl.obolibrary.org/obo/HP_0030337		
HP:0032998	biolink:PhenotypicFeature	Increased cystatin C level	A elevated concentration of cystatin C in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032998		
HP:0005363	biolink:PhenotypicFeature	Humoral immunodeficiency	A general term referring to a defect in immunity resulting from impaired antibody production.	UMLS:C4025206	hp.json		http://purl.obolibrary.org/obo/HP_0005363		
HP:0005364	biolink:PhenotypicFeature	obsolete Severe viral infections			hp.json		http://purl.obolibrary.org/obo/HP_0005364		
HP:0005365	biolink:PhenotypicFeature	Severe B lymphocytopenia	A severe form of B lymphocytopenia in which the count of B cells is very low or absent.	UMLS:C4020824|UMLS:C1863715	hp.json	Absent B cells|Absence of B cells	http://purl.obolibrary.org/obo/HP_0005365		
HP:0005366	biolink:PhenotypicFeature	Recurrent streptococcus pneumoniae infections	Increased susceptibility to streptococcus pneumoniae infections as manifested by a history of recurrent infections by streptococcus pneumoniae.	UMLS:C2169794	hp.json		http://purl.obolibrary.org/obo/HP_0005366		
HP:0005360	biolink:PhenotypicFeature	Susceptibility to chickenpox	Increased susceptibility to chicken pox, as manifested by recurrent episodes of chicken pox.	UMLS:C1855205	hp.json		http://purl.obolibrary.org/obo/HP_0005360		
HP:0030341	biolink:PhenotypicFeature	Decreased circulating follicle stimulating hormone concentration	A reduction of the circulating level of follicle-stimulating hormone (FSH).	UMLS:C4072889	hp.json	Decreased circulating follicle stimulating hormone level	http://purl.obolibrary.org/obo/HP_0030341		
RO:0040036	biolink:NamedThing	results in changes to anatomical or cellular structure	p has anatomical participant c iff p has participant c, and c is an anatomical entity		hp.json		http://purl.obolibrary.org/obo/RO_0040036		
HP:0030344	biolink:PhenotypicFeature	Decreased circulating luteinizing hormone level	A reduction in the circulating level of luteinizing hormone (LH).	UMLS:C4072890	hp.json	Decreased circulating luteinising hormone level	http://purl.obolibrary.org/obo/HP_0030344		
HP:0030340	biolink:PhenotypicFeature	obsolete Increased circulating gonadotropin level			hp.json		http://purl.obolibrary.org/obo/HP_0030340		
HP:0030349	biolink:PhenotypicFeature	Decreased circulating androgen concentration	A reduction in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.	UMLS:C4072894	hp.json	Decreased circulating androgen level	http://purl.obolibrary.org/obo/HP_0030349		
HP:0030345	biolink:PhenotypicFeature	Abnormal circulating luteinizing hormone concentration	An anomaly of the circulating level of luteinizing hormone (LH).	UMLS:C0580438|SNOMEDCT_US:166374003	hp.json	Abnormal circulating luteinizing hormone level|Abnormal luteinizing hormone level|Increased circulating lutropin	http://purl.obolibrary.org/obo/HP_0030345		
HP:0030346	biolink:PhenotypicFeature	Abnormal circulating follicle-stimulating hormone concentration	An anomaly of the circulating level of follicle-stimulating hormone (FSH).	UMLS:C4072891	hp.json	Abnormal circulating follicle-stimulating hormone level	http://purl.obolibrary.org/obo/HP_0030346		
HP:0005379	biolink:PhenotypicFeature	obsolete Severe T lymphocytopenia			hp.json		http://purl.obolibrary.org/obo/HP_0005379		
HP:0030347	biolink:PhenotypicFeature	Abnormal circulating androgen level	An anomaly in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.	UMLS:C4072892	hp.json		http://purl.obolibrary.org/obo/HP_0030347		
HP:0030348	biolink:PhenotypicFeature	Increased circulating androgen concentration	An elevation of the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone.	UMLS:C4072893	hp.json	Increased circulating androgen level	http://purl.obolibrary.org/obo/HP_0030348		
HP:0005374	biolink:PhenotypicFeature	Cellular immunodeficiency	An immunodeficiency characterized by defective cell-mediated immunity or humoral immunity.	UMLS:C1855204	hp.json		http://purl.obolibrary.org/obo/HP_0005374		
HP:0005375	biolink:PhenotypicFeature	obsolete Partial cellular immunodeficiency			hp.json		http://purl.obolibrary.org/obo/HP_0005375		
HP:0005376	biolink:PhenotypicFeature	Recurrent Haemophilus influenzae infections	Increased susceptibility to Haemophilus influenzae infections as manifested by recurrent episodes of infection by Haemophilus influenzae.	UMLS:C4025204	hp.json	Recurrent H. influenzae infections	http://purl.obolibrary.org/obo/HP_0005376		
HP:0005372	biolink:PhenotypicFeature	Abnormality of B cell physiology	An abnormality of the physiological functioning of B cells.	UMLS:C1849242	hp.json	Abnormality of B cell physiology|Reduced B cell function	http://purl.obolibrary.org/obo/HP_0005372		
GO:0031052	biolink:BiologicalProcess	programmed DNA elimination by chromosome breakage	Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.		hp.json	chromosome breakage	http://purl.obolibrary.org/obo/GO_0031052		
GO:0031049	biolink:BiologicalProcess	programmed DNA elimination	A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing.		hp.json		http://purl.obolibrary.org/obo/GO_0031049		goslim_pir
HP:0030352	biolink:PhenotypicFeature	Abnormal serum insulin-like growth factor 1 level	An anomalous level of insulin-like growth factor 1 (IGF1) in the blood circulation.	UMLS:C4072896	hp.json		http://purl.obolibrary.org/obo/HP_0030352		
HP:0030353	biolink:PhenotypicFeature	Decreased serum insulin-like growth factor 1	A reduced level of insulin-like growth factor 1 (IGF1) in the blood circulation.	UMLS:C4072897	hp.json		http://purl.obolibrary.org/obo/HP_0030353		
GO:0006089	biolink:BiologicalProcess	lactate metabolic process	The chemical reactions and pathways involving lactate, the anion of lactic acid.		hp.json	2-hydroxypropanoate metabolism|lactate metabolism|2-hydroxypropanoate metabolic process|alpha-hydroxypropionate metabolism|alpha-hydroxypropionate metabolic process	http://purl.obolibrary.org/obo/GO_0006089		
HP:0030354	biolink:PhenotypicFeature	Abnormal serum interferon level	Abnormal levels of interferon in the blood.	UMLS:C4072898	hp.json		http://purl.obolibrary.org/obo/HP_0030354		
HP:0030355	biolink:PhenotypicFeature	Abnormal serum interferon-gamma level	Abnormal levels of interferon gamma measured in the blood circulation.	UMLS:C4072899	hp.json		http://purl.obolibrary.org/obo/HP_0030355		
HP:0030350	biolink:PhenotypicFeature	Erythematous papule	A circumscribed, solid elevation of skin with no visible fluid that is reddish (erythematous) in color.	UMLS:C0747241	hp.json	Red-blue papule	http://purl.obolibrary.org/obo/HP_0030350		
HP:0030351	biolink:PhenotypicFeature	Urticarial plaque	A well-circumscribed, intensely pruritic, raised wheal (edema of the superficial skin) typically 1 to 2 cm in diameter.	UMLS:C4072895	hp.json		http://purl.obolibrary.org/obo/HP_0030351		
GO:0006094	biolink:BiologicalProcess	gluconeogenesis	The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.	Wikipedia:Gluconeogenesis|MetaCyc:GLUCONEO-PWY	hp.json	glucose biosynthesis|glucose biosynthetic process	http://purl.obolibrary.org/obo/GO_0006094		
HP:0005349	biolink:PhenotypicFeature	Hypoplasia of the epiglottis	Hypoplasia of the epiglottis.	UMLS:C1396772	hp.json	Hypoplastic epiglottis	http://purl.obolibrary.org/obo/HP_0005349		
HP:0005345	biolink:PhenotypicFeature	Abnormal vena cava morphology	An abnormality of the structure of the veins that return deoxygenated blood from the body into the heart, i.e., the superior vena cava and the inferior vena cava.	UMLS:C4025210	hp.json	Abnormality of the vena cava	http://purl.obolibrary.org/obo/HP_0005345		
GO:0006090	biolink:BiologicalProcess	pyruvate metabolic process	The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.	MetaCyc:P41-PWY|Wikipedia:Pyruvic_acid	hp.json	pyruvate dehydrogenase bypass|pyruvate metabolism	http://purl.obolibrary.org/obo/GO_0006090		goslim_drosophila
HP:0030356	biolink:PhenotypicFeature	Increased serum interferon-gamma level	An elevation in the concentration of interferon gamma measured in the blood circulation.	UMLS:C4072900	hp.json		http://purl.obolibrary.org/obo/HP_0030356		
GO:0006091	biolink:BiologicalProcess	generation of precursor metabolites and energy	The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.		hp.json	energy pathways|intermediary metabolism|metabolic energy generation	http://purl.obolibrary.org/obo/GO_0006091		prokaryote_subset|goslim_plant|goslim_pir|goslim_pombe|goslim_drosophila|goslim_chembl|goslim_metagenomics|goslim_yeast|goslim_candida|goslim_generic
HP:0005346	biolink:PhenotypicFeature	Abnormal facial expression		UMLS:C4025209	hp.json	Abnormal facial expression	http://purl.obolibrary.org/obo/HP_0005346		
HP:0030357	biolink:PhenotypicFeature	Small cell lung carcinoma	Small cell lung cancer (SCLC) is a type of highly malignant lung cancer that is composed of small ovoid cells. In the past, SCLC was called oat cell carcinoma because the microscopic appearance of the cells was felt to resemble oats. SLCLC usually originates near the bronchi and in many cases may grow and metastasize quickly.	MSH:D055752|UMLS:C0149925|SNOMEDCT_US:254633006|SNOMEDCT_US:254632001	hp.json	Oat cell lung cancer|Oat cell carcinoma of lung|Small cell lung cancer	http://purl.obolibrary.org/obo/HP_0030357		
HP:0030358	biolink:PhenotypicFeature	Non-small cell lung carcinoma		UMLS:C0007131|MSH:D002289|SNOMEDCT_US:254637007	hp.json	Non-small cell lung cancer	http://purl.obolibrary.org/obo/HP_0030358		
HP:0005347	biolink:PhenotypicFeature	Tracheal cartilaginous sleeve	Tracheal cartilaginous sleeve (TCS) is a rare congenital airway malformation in which distinct tracheal rings are replaced by a continuous cartilaginous segment. Vertically fused C- or O-shaped cartilaginous rings can extend from the subglottis to the carina or bronchus with little to no pars membranacea posteriorly. Comment:Tracheal cartilaginous sleeve has been associated with various craniosynostosis syndromes.	UMLS:C1863363	hp.json		http://purl.obolibrary.org/obo/HP_0005347		
HP:0030359	biolink:PhenotypicFeature	Squamous cell lung carcinoma	A type of non-small cell lung carcinoma that is derived from stratified squamous epithelial cells.	SNOMEDCT_US:254634000|UMLS:C0149782	hp.json		http://purl.obolibrary.org/obo/HP_0030359		
HP:0005348	biolink:PhenotypicFeature	Inspiratory stridor	Inspiratory stridor is a high pitched sound upon inspiration that is generally related to laryngeal abnormalities.	SNOMEDCT_US:58596002|UMLS:C0677600	hp.json		http://purl.obolibrary.org/obo/HP_0005348		
HP:0005341	biolink:PhenotypicFeature	Autonomic bladder dysfunction	Abnormal bladder function (increased urge or frequency of urination or urge incontinence) resulting from abnormal functioning of the autonomic nervous system.	UMLS:C4025212	hp.json		http://purl.obolibrary.org/obo/HP_0005341		
HP:0005343	biolink:PhenotypicFeature	Hypoplasia of the bladder	Underdevelopment of the urinary bladder.	UMLS:C1855335	hp.json	Underdeveloped bladder|Hypoplastic bladder	http://purl.obolibrary.org/obo/HP_0005343		
HP:0005344	biolink:PhenotypicFeature	Abnormal carotid artery morphology	Any structural abnormality of the carotid arteries, including the common carotid artery and its' arterial branches.	UMLS:C4025211	hp.json	Abnormality of the carotid arteries	http://purl.obolibrary.org/obo/HP_0005344		
HP:0005340	biolink:PhenotypicFeature	Spastic/hyperactive bladder		UMLS:C1836904	hp.json		http://purl.obolibrary.org/obo/HP_0005340		
HP:0030363	biolink:PhenotypicFeature	Primary Caesarian section	Delivery by Caesarian section representing the first time the mother has delivered by Caesarian section.	UMLS:C4072903	hp.json		http://purl.obolibrary.org/obo/HP_0030363		
HP:0030364	biolink:PhenotypicFeature	Secondary Caesarian section	Delivery by Caesarian section representing where the mother has already had a previous Cesarean delivery, and this is a repeat Cesarean birth.	UMLS:C4072904	hp.json		http://purl.obolibrary.org/obo/HP_0030364		
HP:0030365	biolink:PhenotypicFeature	Vaginal birth after Caesarian	Vaginal birth after Caesarian (VBAC) refers to the situation where the mother has had a previous Cesarean delivery but has now delivered vaginally.	MSH:D016064|UMLS:C0080301	hp.json		http://purl.obolibrary.org/obo/HP_0030365		
HP:0030366	biolink:PhenotypicFeature	Delivery by Odon device	The Odon device is an instrument for assisted vaginal deliveries that is applied on the head of the baby and used to apply traction to assist the birth process.	UMLS:C4072905	hp.json		http://purl.obolibrary.org/obo/HP_0030366		
HP:0030360	biolink:PhenotypicFeature	Large cell lung carcinoma	A type of non-small cell lung carcinoma that is derived from undifferentiated malignant neoplasms originating from transformed epithelial cells in the lung, and which is differentiate from small-cell lung carcinoma by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of salt-and-pepper appearance of the chromatin.	UMLS:C0345958|SNOMEDCT_US:254629004	hp.json		http://purl.obolibrary.org/obo/HP_0030360		
GO:0006096	biolink:BiologicalProcess	glycolytic process	The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.	MetaCyc:GLYCOLYSIS-VARIANTS	hp.json	anaerobic glycolysis|Embden-Meyerhof-Parnas pathway|glycolysis|Embden-Meyerhof pathway|modifed Embden-Meyerhof pathway	http://purl.obolibrary.org/obo/GO_0006096		
HP:0030361	biolink:PhenotypicFeature	Abnormal circulating eicosanoid concentration	Any deviation from the normal concentration in the blood circulation of an icosanoid (also known as eicosanoids). These are signaling molecules derived from oxidation of 20-carbon fatty acids. Most are produced from arachidonic acid, a 20-carbon polyunsaturated fatty acid (5,8,11,14-eicosatetraenoic acid).	UMLS:C4072901	hp.json	Abnormality of icosanoid metabolism	http://purl.obolibrary.org/obo/HP_0030361		
HP:0030362	biolink:PhenotypicFeature	Reduced muscle carnitine level	A reduction in the level of carnitine in muscle tissue.	UMLS:C4072902	hp.json		http://purl.obolibrary.org/obo/HP_0030362		
HP:0030367	biolink:PhenotypicFeature	Finger hyperphalangy	Hyperphalangy is a digit morphology in which increased numbers of phalanges are arranged linearly within a digit. That is, there is an accessory phalanx that is arranged linearly with the other phalanges.	UMLS:C4072906	hp.json		http://purl.obolibrary.org/obo/HP_0030367		
HP:0005356	biolink:PhenotypicFeature	Decreased serum complement factor I	A reduced level of the complement component Factor I in circulation.	UMLS:C1970257	hp.json		http://purl.obolibrary.org/obo/HP_0005356		
HP:0005357	biolink:PhenotypicFeature	Defective B cell differentiation	Reduced functionality of the process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.	UMLS:C1859624	hp.json		http://purl.obolibrary.org/obo/HP_0005357		
HP:0030368	biolink:PhenotypicFeature	Hyperphalangy of the 2nd finger	An accessory phalanx of the index (second) finger that is arranged linearly with the other phalanges. Hyperphalangy of the index finger results from an accessory ossification center at the metacarpophalangeal joint, resulting in radial deviation of the index finger. Note that this term refers only to this type of hyperphalangy.	UMLS:C4072907	hp.json	Hyperphalangy of index finger	http://purl.obolibrary.org/obo/HP_0030368		
HP:0030369	biolink:PhenotypicFeature	Induced vaginal delivery	Vaginal delivery following induction of labor, a procedure used to stimulate uterine contractions during pregnancy before labor begins on its own.	UMLS:C4072908	hp.json		http://purl.obolibrary.org/obo/HP_0030369		
HP:0005359	biolink:PhenotypicFeature	Aplasia of the thymus	Absence of the thymus. This feature may be appreciated by the lack of a thymic shadow upon radiographic examination.	SNOMEDCT_US:702623002|UMLS:C0685894|MSH:C536288|SNOMEDCT_US:91918005	hp.json	Absent thymic shadow|Athymia|Absent thymus|Lack of thymic shadow	http://purl.obolibrary.org/obo/HP_0005359		
HP:0005352	biolink:PhenotypicFeature	Severe T-cell immunodeficiency	A primary immune deficiency that is characterized by defects or deficiencies of T-lymphocytes that causes specific susceptibility to intracellular micro-organisms.	UMLS:C4025208	hp.json	Severe T-cell immunodeficiency	http://purl.obolibrary.org/obo/HP_0005352		
HP:0005353	biolink:PhenotypicFeature	Recurrent herpes	Increased susceptibility to herpesvirus, as manifested by recurrent episodes of herpesvirus.	UMLS:C4025207	hp.json	Susceptibility to herpesvirus	http://purl.obolibrary.org/obo/HP_0005353		
HP:0005354	biolink:PhenotypicFeature	Lack of T cell function	Complete inability of T cells to perform their functions in cell-mediated immunity.	UMLS:C1849426	hp.json	Absent cellular immunity	http://purl.obolibrary.org/obo/HP_0005354		
GO:0033696	biolink:BiologicalProcess	heterochromatin boundary formation	A process that forms a boundary that limits the spreading of heterochromatin along a chromosome.		hp.json	negative regulation of extent of heterochromatin assembly|maintenance of heterochromatin boundaries|negative regulation of heterochromatin spreading|negative regulation of extent of heterochromatin formation|regulation of extent of heterochromatin formation|regulation of heterochromatin spreading|regulation of extent of heterochromatin assembly	http://purl.obolibrary.org/obo/GO_0033696		
GO:0031032	biolink:BiologicalProcess	actomyosin structure organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.		hp.json	actomyosin structure organisation|actomyosin structure organization and biogenesis|actomyosin organization	http://purl.obolibrary.org/obo/GO_0031032		
GO:0033692	biolink:NamedThing	cellular polysaccharide biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0033692		
HP:0032951	biolink:PhenotypicFeature	Renal tubular viral cytopathic changes	Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. Distal tubules are more commonly involved than proximal tubules. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbers of neutrophils, with interstitial edema and hemorrhage. Tubular destruction may be associated with necrotizing interstitial granulomas. Severe granulomatous tubulointerstitial nephritis appears to be characteristic of adenoviral infection and is quite rare in other viral infections. Focal wedge-shaped necrosis may occur in renal parenchyma. Immunostaining for adenovirus shows strong nuclear and cytoplasmic staining in infected cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032951		
HP:0032950	biolink:PhenotypicFeature	Abnormal renal tubular lumen morphology	Abnormal structure or form of the lumen (opening) of kidney tubules.		hp.json	Abnormal renal tubular luminal morphology	http://purl.obolibrary.org/obo/HP_0032950		
GO:0006066	biolink:BiologicalProcess	alcohol metabolic process	The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.		hp.json	alcohol metabolism	http://purl.obolibrary.org/obo/GO_0006066		goslim_pir|goslim_drosophila
HP:0032957	biolink:PhenotypicFeature	Dysmorphic hematuria	The presence of dysmorphic urinary erythrocytes. This feature can be observed by phase-contrastmicroscopy, differential interference microscopy, and bright-field microscopy. The acanthocyte or G1 cell, which is a doughnut-shaped cell with one or more blebs, is reported to constitute a special form of dysmorphic erythro-cyte (D cell) specific for glomerular hematuria.		hp.json	Acanthocyturia	http://purl.obolibrary.org/obo/HP_0032957		
HP:0032956	biolink:PhenotypicFeature	Renal tubular herpes simplex virus inclusions	Renal tubular nuclear inclusions that stain positive for herpes simplex virus (HSV). HSV is typically associated with multinucleated giant cells with nuclear inclusions and may cause hemorrhagic interstitial nephritis.		hp.json		http://purl.obolibrary.org/obo/HP_0032956		
GO:0006073	biolink:NamedThing	cellular glucan metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0006073		
HP:0032959	biolink:PhenotypicFeature	Intratubular calcium oxalate casts	Birefringent calcium- and oxalate-containing casts located within the tubuli of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032959		
HP:0032958	biolink:PhenotypicFeature	Urinary oval fat bodies	The presence in the urine of desquamated tubular epithelial cells or macrophages filled with lipid droplets.		hp.json		http://purl.obolibrary.org/obo/HP_0032958		
HP:0032953	biolink:PhenotypicFeature	Renal tubular cytomegalovirus inclusions	Characteristic intranuclear glassy-appearing basophilic inclusions with surrounding halo (owl's eye-type inclusion) and marked increase in the size of the cell (cytomegaly), particularly in tubular epithelial cells and in endothelial cells. Often accompanied by cytopathic changes including patchy interstitial pleomorphic infiltrate with lymphocytes, plasma cells, and macrophages.		hp.json		http://purl.obolibrary.org/obo/HP_0032953		
HP:0032952	biolink:PhenotypicFeature	Usual-type tubular atrophy	A type of renal tubular atrophy in which the tubules show thick tubular basement membranes lined by small cuboidal or flat cells. Generally accompanied by fibrosis.		hp.json	Common-type renal tubular atrophy	http://purl.obolibrary.org/obo/HP_0032952		
HP:0032955	biolink:PhenotypicFeature	Renal tubular polyoma virus inclusions	Renal ltubular nuclear inclusions have a ground-glass appearance with irregular central clearing, or a coarse, vesicular appearance. Distal tubules are involved more often than proximal tubules. There may be only medullary involvement in early stages, and parietal epithelial cells may be involved in later stages of the infection. Infected epithelial cell nuclei stain with antibody to the large T antigen of the SV40 virus, which serves as a surrogate marker of human polyomavirus infection.		hp.json		http://purl.obolibrary.org/obo/HP_0032955		
HP:0032954	biolink:PhenotypicFeature	Renal tubular adenovirus inclusions	Viral cytopathic changes consist of smudgy basophilic intranuclear inclusions with enlarged nuclei of infected cells. The inclusions stain positive for adenovirus (e.g., Figure 3 of PMID:29273157). Distal tubules are more commonly involved than proximal tubules. Occasionally glomerular visceral and parietal epithelial cells can be infected. There is associated acute tubular injury, often with frank tubular necrosis and destruction, with acute interstitial nephritis, often with a pleomorphic infiltrate composed of lymphocytes, histiocytes, plasma cells, and variable numbersof neutrophils, with interstitial edema and hemorrhage.		hp.json		http://purl.obolibrary.org/obo/HP_0032954		
OBO:MAXO_0000493	biolink:NamedThing	cardiovascular diagnostic procedure	Procedure to evaluate the structure and/or function of the cardiovascular system.	NCIT:C100084|CMO:0000001	hp.json	cardiovascular measurement	http://purl.obolibrary.org/obo/MAXO_0000493		
OBO:MAXO_0000494	biolink:NamedThing	blood pressure measurement	Measurement of the pressure on the walls of the vessels as blood moves around the body. Systolic blood pressure is the pressure when the heart beats – while the heart muscle is contracting (squeezing) and pumping oxygen-rich blood into the blood vessels. Diastolic blood pressure is the pressure on the blood vessels when the heart muscle relaxes. The diastolic pressure is always lower than the systolic pressure.	CMO:0000003|NCBIBook:NBK279251	hp.json	blood pressure assessment|blood pressure monitoring	http://purl.obolibrary.org/obo/MAXO_0000494		
OBO:MAXO_0000491	biolink:NamedThing	pulse assessment	Assessment and recording of arterial pulses in any of a number of locations. The observer should note its intensity, rate, rhythm, and if any blood vessel tenderness, tortuosity, or nodularity exists.	NCBIBook:NBK350	hp.json		http://purl.obolibrary.org/obo/MAXO_0000491		
OBO:MAXO_0000492	biolink:NamedThing	respiratory rate assessment	The rate of breathing (inhalation and exhalation) measured within in a unit time, usually expressed as breaths per minute.	NCIT:C49678|CMO:0000289	hp.json		http://purl.obolibrary.org/obo/MAXO_0000492		
OBO:MAXO_0000497	biolink:NamedThing	noninvasive blood pressure measurement	A method for monitoring blood pressure without requiring instruments introduced into the body.	VSO:0000024|PMID:20937442|NCIT:C69319	hp.json	non-invasive blood presure measurement	http://purl.obolibrary.org/obo/MAXO_0000497		
OBO:MAXO_0000498	biolink:NamedThing	invasive blood pressure measurement	An intra-arterial method of monitoring blood pressure.	VSO:0000023	hp.json		http://purl.obolibrary.org/obo/MAXO_0000498		
OBO:MAXO_0000495	biolink:NamedThing	auscultatory blood pressure measurement	Monitoring blood pressure with a sphygmomanometer and a stethoscope to hear blood flow.	VSO:0000001|MMO:0000055|PMID:20937442|NCIT:C69318	hp.json	auscultatory blood pressure measurement process|auscultatory blood pressure monitoring|ausculatory sphygmomanometer blood pressure measurement	http://purl.obolibrary.org/obo/MAXO_0000495		
OBO:MAXO_0000496	biolink:NamedThing	oscillometric blood pressure measurement	A blood pressure measurement using a sphygmomanometer and an electronic pressure sensor (transducer) that detects blood flow by the presence of oscillations in the cuff pressure.	VSO:0000026|PMID:20937442|NCIT:C69319	hp.json		http://purl.obolibrary.org/obo/MAXO_0000496		
GO:0045600	biolink:BiologicalProcess	positive regulation of fat cell differentiation	Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.		hp.json	positive regulation of adipocyte differentiation|stimulation of fat cell differentiation|up regulation of fat cell differentiation|positive regulation of adipocyte cell differentiation|up-regulation of fat cell differentiation|activation of fat cell differentiation|upregulation of fat cell differentiation	http://purl.obolibrary.org/obo/GO_0045600		
HP:0032960	biolink:PhenotypicFeature	Intratubular calcium phosphate casts	Purple and finely granular/laminated calcium- and phosphate-containing casts located within the tubuli of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0032960		
GO:0045601	biolink:BiologicalProcess	regulation of endothelial cell differentiation	Any process that modulates the frequency, rate or extent of endothelial cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0045601		
HP:0032962	biolink:PhenotypicFeature	Tubular microcystic change	Dilated renal tubules (over twice the diameter of a normal proximal tubule) containing eosinophilic amorphous material. This feature is generally accompanied by scalloping of the cast profile. The epithelium lining the microcyst is generally flattened and does not reveal brush border.		hp.json		http://purl.obolibrary.org/obo/HP_0032962		
HP:0030300	biolink:PhenotypicFeature	10 pairs of ribs	Presence of only 10 (instead of the usual 12) pairs of ribs.	UMLS:C4022526	hp.json	10 pairs of ribs	http://purl.obolibrary.org/obo/HP_0030300		
HP:0032961	biolink:PhenotypicFeature	Magnesium ammonium phosphate crystalluria	Magnesium ammonium phosphate crystals in the urine.		hp.json	Struvite urinary crystals	http://purl.obolibrary.org/obo/HP_0032961		
OBO:MAXO_0000490	biolink:NamedThing	heart rate measurement	An assessment of the number of heartbeats per unit time, usually expressed as beats per minute.	NCIT:C49677|CMO:0000002	hp.json	heart rate assessment|HR measurement	http://purl.obolibrary.org/obo/MAXO_0000490		
HP:0032968	biolink:PhenotypicFeature	Expiratory air trapping	Abnormal retention of gas within a lung or part of a lung, as a result of airway obstuction of abnormalities in lung compliance. In the classic presentation, the lung will appear normal at inspiration, but on exhalation, the diseased portions of the lung which have lost connective tissue recoil will remain lucent while the healthy portions of the lung will become more dense due to atelectasis. This helps distinguish it from mosaic attenuation due to patchy fibrosis, as occurs with nonspecific interstitial pneumonia, and in early usual interstitial pneumonitis (the hallmark imaging diagnosis of interstitial lung disease) in which there is no change with inspiration and expiration.		hp.json		http://purl.obolibrary.org/obo/HP_0032968		
HP:0030305	biolink:PhenotypicFeature	Decreased number of vertebrae		UMLS:C4022522	hp.json		http://purl.obolibrary.org/obo/HP_0030305		
HP:0032967	biolink:PhenotypicFeature	Panacinar emphysema	Panacinar emphysema involves all portions of the acinus and secondary pulmonary lobule more or less uniformly. It predominates in the lower lobes and is the form of emphysema associated with1-antitrypsin deficiency. CT scans show a generalized decrease of the lung parenchyma with a decrease in the caliber of blood vessels in the affected lung. Severe panacinar emphysema may coexist and merge with severe centrilobular emphysema. The appearance of feature less decreased attenuation may be indistinguishable from severe constrictive obliterative bronchiolitis.		hp.json		http://purl.obolibrary.org/obo/HP_0032967		
HP:0030306	biolink:PhenotypicFeature	11 thoracic vertebrae	The presence of 11 instead of the normal 12 thoracic vertebrae.	UMLS:C4022521	hp.json		http://purl.obolibrary.org/obo/HP_0030306		
GO:0045606	biolink:BiologicalProcess	positive regulation of epidermal cell differentiation	Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.		hp.json	positive regulation of hypodermal cell differentiation|stimulation of epidermal cell differentiation|up-regulation of epidermal cell differentiation|activation of epidermal cell differentiation|upregulation of epidermal cell differentiation|up regulation of epidermal cell differentiation	http://purl.obolibrary.org/obo/GO_0045606		
GO:0006081	biolink:BiologicalProcess	cellular aldehyde metabolic process	The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.		hp.json	alkanal metabolic process|aldehyde metabolism|alkanal metabolism	http://purl.obolibrary.org/obo/GO_0006081		goslim_pir
HP:0030307	biolink:PhenotypicFeature	Flared lower limb metaphysis	The presence of a splayed (i.e.,flared) metaphyseal segment of one or more long bones of the leg.	UMLS:C4022520	hp.json	Flared metaphysis of lower limb bone	http://purl.obolibrary.org/obo/HP_0030307		
HP:0030308	biolink:PhenotypicFeature	Flared distal tibial metaphysis	The presence of a splayed (i.e.,flared) metaphyseal segment of the distal tibia.	UMLS:C4022519	hp.json	Flared outermost metaphysis of shankbone|Flared outermost metaphysis of shinbone	http://purl.obolibrary.org/obo/HP_0030308		
HP:0032969	biolink:PhenotypicFeature	Traction bronchiectasis	Distortion of the bronchial airways due to mechanical traction on the bronchi resulting from fibrosis of the surrounding lung parenchyma. CT findings represent irregular bronchial dilatation caused by surrounding retractile pulmonary fibrosis. Dilated airways are usually identifiable as such but may be seen as cysts.		hp.json		http://purl.obolibrary.org/obo/HP_0032969		
GO:0006082	biolink:BiologicalProcess	organic acid metabolic process	The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.		hp.json	organic acid metabolism	http://purl.obolibrary.org/obo/GO_0006082		goslim_pir
GO:0045604	biolink:BiologicalProcess	regulation of epidermal cell differentiation	Any process that modulates the frequency, rate or extent of epidermal cell differentiation.		hp.json	regulation of hypodermal cell differentiation	http://purl.obolibrary.org/obo/GO_0045604		
HP:0030301	biolink:PhenotypicFeature	Abnormality of the anterior commissure	An anomaly of the anterior commissure, a bundle of nerve fibers that connect the two cerebral hemispheres across the midline. The anterior commissure plays a role in pain sensation and contains decussating fibers from the olfactory tracts.	UMLS:C4022525	hp.json		http://purl.obolibrary.org/obo/HP_0030301		
HP:0032964	biolink:PhenotypicFeature	Uric acid crystalluria	The presence of uric acid crystals in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032964		
HP:0032963	biolink:PhenotypicFeature	Complex renal cyst	A renal cyst characterized by epithelium lined space (squamous/columnar) with septations.		hp.json		http://purl.obolibrary.org/obo/HP_0032963		
GO:0045605	biolink:BiologicalProcess	negative regulation of epidermal cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal cell differentiation.		hp.json	downregulation of epidermal cell differentiation|negative regulation of hypodermal cell differentiation|down regulation of epidermal cell differentiation|inhibition of epidermal cell differentiation|down-regulation of epidermal cell differentiation	http://purl.obolibrary.org/obo/GO_0045605		
HP:0030302	biolink:PhenotypicFeature	Agenesis of the anterior commissure	Absence of the anterior commissure.	UMLS:C1851087	hp.json		http://purl.obolibrary.org/obo/HP_0030302		
HP:0032966	biolink:PhenotypicFeature	Centrilobular emphysema	A type of emphysema characterized by destroyed centrilobular alveolar walls and enlargement of respiratory bronchioles and associated alveoli. This is the commonest form of emphysema in cigarette smokers. CT findings are centrilobular areas of decreased attenuation, usually without visible walls, of nonuniform distribution and predominantly located in upper lung zones.		hp.json	Centriacinar emphysema	http://purl.obolibrary.org/obo/HP_0032966		
GO:0045602	biolink:BiologicalProcess	negative regulation of endothelial cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.		hp.json	downregulation of endothelial cell differentiation|down regulation of endothelial cell differentiation|inhibition of endothelial cell differentiation|down-regulation of endothelial cell differentiation	http://purl.obolibrary.org/obo/GO_0045602		
HP:0030303	biolink:PhenotypicFeature	Hypoplastic anterior commissure	Underdevelopment of the anterior commissure.	UMLS:C4022524	hp.json		http://purl.obolibrary.org/obo/HP_0030303		
GO:0045603	biolink:BiologicalProcess	positive regulation of endothelial cell differentiation	Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation.		hp.json	up-regulation of endothelial cell differentiation|activation of endothelial cell differentiation|upregulation of endothelial cell differentiation|up regulation of endothelial cell differentiation|stimulation of endothelial cell differentiation	http://purl.obolibrary.org/obo/GO_0045603		
HP:0032965	biolink:PhenotypicFeature	Interstitial emphysema	Interstitial emphysema is characterized by air dissecting within the interstitium of the lung, typically in the peribronchovascular sheaths, interlobular septa, and visceral pleura. It is most commonly seen in neonates receiving mechanical ventilation. It is rarely recognized radiographically in adults and is infrequently seen on CT scans. It appears as perivascular lucent or low attenuating halos and small cysts.		hp.json		http://purl.obolibrary.org/obo/HP_0032965		
HP:0030304	biolink:PhenotypicFeature	Abnormal number of vertebrae	A deviation from the normal number of vertebrae in the spinal column.	UMLS:C4022523	hp.json		http://purl.obolibrary.org/obo/HP_0030304		
GO:0031012	biolink:CellularComponent	extracellular matrix	A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.	Wikipedia:Extracellular_matrix|NIF_Subcellular:nlx_subcell_20090513	hp.json	proteinaceous extracellular matrix|matrisome	http://purl.obolibrary.org/obo/GO_0031012		goslim_generic|prokaryote_subset|goslim_pir|goslim_drosophila|goslim_chembl
GO:0033674	biolink:BiologicalProcess	positive regulation of kinase activity	Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.		hp.json	kinase activator|up-regulation of kinase activity|up regulation of kinase activity|stimulation of kinase activity|upregulation of kinase activity	http://purl.obolibrary.org/obo/GO_0033674		
GO:0033673	biolink:BiologicalProcess	negative regulation of kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.		hp.json	down regulation of kinase activity|downregulation of kinase activity|inhibition of kinase activity|kinase inhibitor|down-regulation of kinase activity	http://purl.obolibrary.org/obo/GO_0033673		
HP:0030309	biolink:PhenotypicFeature	Flared distal fibular metaphysis	The presence of a splayed (i.e.,flared) metaphyseal segment of the distal fibula.	UMLS:C4022518	hp.json	Flared outermost wide portion of of calf bone	http://purl.obolibrary.org/obo/HP_0030309		
GO:0021682	biolink:BiologicalProcess	nerve maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.		hp.json		http://purl.obolibrary.org/obo/GO_0021682		
HP:0005390	biolink:PhenotypicFeature	Recurrent opportunistic infections	Increased susceptibility to opportunistic infections, as manifested by recurrent episodes of infection by opportunistic agents, i.e., by microorganisms that do not usually cause disease in a healthy host, but are able to infect a host with a compromised immune system.	UMLS:C1832324	hp.json	Frequent opportunistic infections	http://purl.obolibrary.org/obo/HP_0005390		
HP:0032971	biolink:PhenotypicFeature	Computed tomographic halo sign	CT finding of ground-glass opacity surrounding a nodule or mass. It was first described as a sign of hemorrhage around foci of invasive aspergillosis. The halo sign is nonspecific and may also be caused by hemorrhage associated with other types of nodules or by local pulmonary infiltration by neoplasm.		hp.json	CT halo sign	http://purl.obolibrary.org/obo/HP_0032971		
HP:0032970	biolink:PhenotypicFeature	Traction bronchiolectasis			hp.json		http://purl.obolibrary.org/obo/HP_0032970		
HP:0030310	biolink:PhenotypicFeature	Upper extremity joint dislocation	Displacement or malalignment of one or more joints in the upper extremity (arm).	UMLS:C4022517	hp.json	Dislocated arm joints	http://purl.obolibrary.org/obo/HP_0030310		
HP:0032973	biolink:PhenotypicFeature	Abnormal bronchoalveolar lavage fluid morphology	Abnormal type or counts of nucleated immune cells and acellular components in bronchoalveolar lavage (BAL) fluid. BAL us performed with a fiberoptic bronchoscope in the wedged position within a selected bronchopulmonary segment. BAL is commonly used to inform the differential diagnosis of interstitial lung disease or to monitor therapeutic interventions.		hp.json		http://purl.obolibrary.org/obo/HP_0032973		
HP:0030311	biolink:PhenotypicFeature	Lower extremity joint dislocation	Displacement or malalignment of one or more joints in the lower extremity (leg).	UMLS:C4022516	hp.json	Dislocated leg joints	http://purl.obolibrary.org/obo/HP_0030311		
HP:0032972	biolink:PhenotypicFeature	Nodular-centrilobular without tree-in-bud pattern on pulmonary HRCT	A nodular pattern on pulmonary high-resolution computed tomography which are anatomically located centrally within secondary pulmonary lobules. Centrilobular nodules may be dense (i.e., solid) and of homogeneous opacity or ground-glass opacity, and may range from a few millimeters to about 1 cm in size. Because of the similar size of secondary lobules, centrilobular nodules often appear to be evenly spaced. Centrilobular nodules are usually separated from the pleural surfaces, fissures, and interlobular septa by a distance of at least several millimeters. They may appear patchy or diffuse in different diseases.		hp.json		http://purl.obolibrary.org/obo/HP_0032972		
GO:0045619	biolink:BiologicalProcess	regulation of lymphocyte differentiation	Any process that modulates the frequency, rate or extent of lymphocyte differentiation.		hp.json	regulation of lymphocyte development	http://purl.obolibrary.org/obo/GO_0045619		
HP:0032979	biolink:PhenotypicFeature	Hemosiderin-laden macrophages in bronchoalveolar fluid	Hemosiderin-laden macrophages (HLM) in bronchoalveolar lavage (BAL) fluid were originally known as adiagnostic biomarker of alveolar hemorrhage, but have also been observed in idiopathic pulmonary fibrosis (IPF) with histopathological pattern of usual interstitial pneumonia (UIP).		hp.json	Accumulation of hemosiderin laden alveolar macrophages|Siderophages in bronchoalveolar fluid	http://purl.obolibrary.org/obo/HP_0032979		
HP:0032978	biolink:PhenotypicFeature	Lipid-laden macrophages in bronchoalveolar fluid	Accumulation of lipids in alveolar macrophages with droplet-shaped fat inclusions.		hp.json		http://purl.obolibrary.org/obo/HP_0032978		
HP:0030318	biolink:PhenotypicFeature	Angular cheilitis	A type of inflammation of the lips involving one or both of the corners of the mouth.	UMLS:C0221237|SNOMEDCT_US:266429005	hp.json	Commissural cheilitis|Angular stomatitis|Inflammation of oral commisures|Angular cheilosis|Red and sore corners of the mouth|Inflammation of corners of the mouth	http://purl.obolibrary.org/obo/HP_0030318		
GO:0045617	biolink:BiologicalProcess	negative regulation of keratinocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.		hp.json	downregulation of keratinocyte differentiation|down regulation of keratinocyte differentiation|inhibition of keratinocyte differentiation|down-regulation of keratinocyte differentiation	http://purl.obolibrary.org/obo/GO_0045617		
HP:0030319	biolink:PhenotypicFeature	Weakness of facial musculature	Reduced strength of one or more muscles innervated by the facial nerve (the seventh cranial nerve).	UMLS:C4022514	hp.json	Facial weakness|Decreased facial muscle strength|Weakness of face|Decreased strength of facial muscles|Face weakness|Reduced facial muscle strength|Facial muscle weakness|Myasthenia of facial muscles|Weakness of facial musculature	http://purl.obolibrary.org/obo/HP_0030319		
GO:0045618	biolink:BiologicalProcess	positive regulation of keratinocyte differentiation	Any process that activates or increases the frequency, rate or extent of keratinocyte differentiation.		hp.json	up regulation of keratinocyte differentiation|stimulation of keratinocyte differentiation|up-regulation of keratinocyte differentiation|activation of keratinocyte differentiation|upregulation of keratinocyte differentiation	http://purl.obolibrary.org/obo/GO_0045618		
HP:0032975	biolink:PhenotypicFeature	Abnormal bronchoalveolar fluid protein level	Any deviation from the normal concentration of protein in the bronchoalveolar fluid.		hp.json	Abnormal biochemical composition of broncho-alveolar fluid|Abnormal level of proteins in the broncho-alveolar fluid	http://purl.obolibrary.org/obo/HP_0032975		
HP:0030312	biolink:PhenotypicFeature	Obliteration of the calvarial diploe	Absence of the spongy bone structure (or tissue) of the internal part of the skull cap (i.e., of the calvarial diploe).	UMLS:C1860855	hp.json	Obliteration of cranial cancellous bone	http://purl.obolibrary.org/obo/HP_0030312		
HP:0005389	biolink:PhenotypicFeature	Depletion of components of the alternative complement pathway	An abnormal reduction in the components of the alternative complement pathway, such as the C3 protein or its cleavage products.	UMLS:C1969220	hp.json		http://purl.obolibrary.org/obo/HP_0005389		
HP:0030313	biolink:PhenotypicFeature	Abnormal periosteum morphology	An anomalous structure of the periosteum, i.e., of the membrane that covers the outer surface of bones.	UMLS:C4022515	hp.json		http://purl.obolibrary.org/obo/HP_0030313		
HP:0032974	biolink:PhenotypicFeature	Abnormal cellular composition of bronchoalveolar fluid	Deviation from the commonly in healthy people observe cellular distribution. Normal ranghes are macrophages over 80%, lymphocytes less than 15%, neutrophils less than 3%, eosinophils less than 0.5%, mast cells less than 0.5%.		hp.json	Abnormal cell differential of broncho-alveolar fluid	http://purl.obolibrary.org/obo/HP_0032974		
GO:0045616	biolink:BiologicalProcess	regulation of keratinocyte differentiation	Any process that modulates the frequency, rate or extent of keratinocyte differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0045616		
HP:0032977	biolink:PhenotypicFeature	Elevated bronchoalveolar lavage fluid neutrophil proportion	Usually, Neutrophils make up less than 3% of all cells found in the broncho-alveloar lavage fluid. In children, standard value of neutrophils is higher depending on their age (children under the age of 5 show a maximum value of 10%). This elevated cell proportion is a sign for acute and chronic infections (HP:0012387, HP:0006538) and can be associated to specific diseases.		hp.json	Elevated level of neutrophils in broncho-alveolar lavage fluid	http://purl.obolibrary.org/obo/HP_0032977		
HP:0030314	biolink:PhenotypicFeature	Periostosis	Abnormal deposition of periosteal bone.	UMLS:C1409412	hp.json		http://purl.obolibrary.org/obo/HP_0030314		
HP:0032976	biolink:PhenotypicFeature	Elevated bronchoalveolar lavage fluid lymphocyte proportion	Usually, Lymphoycytes make up less than 15% of all cells found in the bronchoalveloar lavage fluid. This elevated cell proportion can be induced by virus or drugs, or is associated with specific diseases.		hp.json		http://purl.obolibrary.org/obo/HP_0032976		
HP:0005386	biolink:PhenotypicFeature	Recurrent protozoan infections	Increased susceptibility to protozoan infections, as manifested by recurrent episodes of protozoan infection.	UMLS:C4025202	hp.json		http://purl.obolibrary.org/obo/HP_0005386		
HP:0005387	biolink:PhenotypicFeature	Combined immunodeficiency	A group of phenotypically heterogeneous genetic disorders characterized by profound deficiencies of T- and B-cell function, which predispose the patients to both infectious and noninfectious complications.	UMLS:C0494261	hp.json		http://purl.obolibrary.org/obo/HP_0005387		
HP:0005381	biolink:PhenotypicFeature	Recurrent meningococcal disease	Recurrent infections by Neisseria meningitidis (one of the most common causes of bacterial meningitis), which is also known as meningococcus.	UMLS:C1970263	hp.json	Increased susceptibility to neisseria meningitidis infections	http://purl.obolibrary.org/obo/HP_0005381		
HP:0005384	biolink:PhenotypicFeature	Defective B cell activation	A reduced ability of a B cell to become activated, i.e., the change in morphology and behavior of	UMLS:C1846551	hp.json		http://purl.obolibrary.org/obo/HP_0005384		
GO:0021675	biolink:BiologicalProcess	nerve development	The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0021675		
HP:0032982	biolink:PhenotypicFeature	obsolete Intraalveolar phospholipid accumulation			hp.json		http://purl.obolibrary.org/obo/HP_0032982		
HP:0030320	biolink:PhenotypicFeature	Increased intervertebral space	An increase in the vertical distance between adjacent vertebral bodies, observed as an increase in the intervertebral disc space.	UMLS:C4022513	hp.json		http://purl.obolibrary.org/obo/HP_0030320		
HP:0032981	biolink:PhenotypicFeature	Absent bronchoalveolar dimeric surfactant-protein B	Significantly decreased level or failed detection of surfactant protein B in broncho-alveolar lavage fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0032981		
GO:0045620	biolink:BiologicalProcess	negative regulation of lymphocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte differentiation.		hp.json	inhibition of lymphocyte differentiation|negative regulation of lymphocyte development|down-regulation of lymphocyte differentiation|downregulation of lymphocyte differentiation|down regulation of lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_0045620		
HP:0030321	biolink:PhenotypicFeature	Abnormal vertebral artery morphology	An anomaly of the vertebral artery, the major artery of the neck that originates from the subclavian artery and merges to form the single midline basilar artery in a complex called the vertebrobasilar system.	UMLS:C4022512	hp.json	Abnormality of the vertebral artery	http://purl.obolibrary.org/obo/HP_0030321		
HP:0032984	biolink:PhenotypicFeature	Abnormal alveolar macrophage morphology	Alveolar macrophages usually make up the majority of cells in the bronchoalveolar space (over 80%). The may contain intracellular material depending on underlying diseases or due to exposition to inhaled particles.		hp.json		http://purl.obolibrary.org/obo/HP_0032984		
HP:0030322	biolink:PhenotypicFeature	Vertebral artery hypoplasia	Underdevelopment of the vertebral artery.	UMLS:C1868737	hp.json		http://purl.obolibrary.org/obo/HP_0030322		
GO:0045621	biolink:BiologicalProcess	positive regulation of lymphocyte differentiation	Any process that activates or increases the frequency, rate or extent of lymphocyte differentiation.		hp.json	upregulation of lymphocyte differentiation|positive regulation of lymphocyte development|up regulation of lymphocyte differentiation|stimulation of lymphocyte differentiation|up-regulation of lymphocyte differentiation|activation of lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_0045621		
HP:0032983	biolink:PhenotypicFeature	Atoll sign	CT finding of central ground-glass opacity surrounded by denser consolidation of crescentic shape (forming more than three-fourths of a circle) or complete ring of at least 2 mm in thicknes. A rare sign, it was initially reported to be specific for cryptogenic organizing pneumonia, but was subsequently described in patients with paracoccidioidomycosis.		hp.json	Reversed halo sign	http://purl.obolibrary.org/obo/HP_0032983		
HP:0032980	biolink:PhenotypicFeature	Absent bronchoalveolar surfactant-protein C	Significantly decreased level or failed detection of surfactant protein C in broncho-alveolar lavage fluid. Comment: Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions, whereas SP-B and SP-C are hydrophobic molecules, which play a direct role in the organization of the surfactant structure in the interphase and in the stabilization of the lipid layers during the respiratory cycle. Lack of SP-C may result of surfactant metabolism dysfunction and is also observed in patients with other diffuse parenchymal lung diseaes, pathogenetically related to the alveolar surfactant region.		hp.json		http://purl.obolibrary.org/obo/HP_0032980		
HP:0030327	biolink:PhenotypicFeature	Abnormal osteoclast count	An anomaly in the number of osteoclasts in bone tissue, bone-resorbing cells that develop from macrophages. This finding can be observed by histological examination of bone tissue.	UMLS:C4022508	hp.json		http://purl.obolibrary.org/obo/HP_0030327		
HP:0030328	biolink:PhenotypicFeature	Decreased osteoclast count	Decreased number of osteoclasts in bone tissue.	UMLS:C4022507	hp.json		http://purl.obolibrary.org/obo/HP_0030328		
PR:000009978	biolink:Protein	lactotransferrin	A protein that is a translation product of the human LTF gene or a 1:1 ortholog thereof.		hp.json	LF|LTF|lactoferrin|GIG12|talalactoferrin	http://purl.obolibrary.org/obo/PR_000009978		
HP:0032989	biolink:PhenotypicFeature	Delayed ability to roll over	Delayed ahcievement of the ability to roll front to back and back to front.		hp.json		http://purl.obolibrary.org/obo/HP_0032989		
HP:0030329	biolink:PhenotypicFeature	Retinal thinning	Reduced anteroposterior thickness of the retina. This phenotype can be appreciated by retinal optical coherence tomography (OCT).	UMLS:C3549703	hp.json	Retinal thinning	http://purl.obolibrary.org/obo/HP_0030329		
HP:0032986	biolink:PhenotypicFeature	Smoker-inclusions in alveolar macrophages	In otherwise healthy smokers, characteristic so called smoker-inclusion can be found within the macrophages in the bronchoalveolar fluid. These blue/ black/ round/ oval cytoplasmic inclusions consist of pigmented lipid deposits.		hp.json		http://purl.obolibrary.org/obo/HP_0032986		
HP:0030323	biolink:PhenotypicFeature	Unilateral vertebral artery hypoplasia	Underdevelopment of the vertebral artery on one side.	UMLS:C3279090	hp.json		http://purl.obolibrary.org/obo/HP_0030323		
HP:0032985	biolink:PhenotypicFeature	Dust particle inclusion in alveolar macrophages	Accumulation of inhaled, nondigestable particles in macrophages.		hp.json		http://purl.obolibrary.org/obo/HP_0032985		
HP:0030324	biolink:PhenotypicFeature	Bilateral vertebral artery hypoplasia	Underdevelopment of the vertebral artery on both sides.	UMLS:C4022511	hp.json		http://purl.obolibrary.org/obo/HP_0030324		
HP:0030325	biolink:PhenotypicFeature	Cervicomedullary schisis	Fissure within the spinal cord of the neck.	UMLS:C4022510	hp.json		http://purl.obolibrary.org/obo/HP_0030325		
HP:0032988	biolink:PhenotypicFeature	Persistent head lag	The Premie-Neuro and the Dubowitz Neurological Examination score head lag in the same manner. Scoring for both is as follows: 0 = head drops and stays back, 1 = tries to lift head but drops it back, 2 = able to lift head slightly, 3 = lifts head in line with body, and 4 = head in front of body. This term applies if head lag persists beyond an expected age at a level of 0 or 1. Persistent head lag beyond age 4 mo has been linked to poor outcomes.		hp.json	Headlag|Head lag	http://purl.obolibrary.org/obo/HP_0032988		
HP:0030326	biolink:PhenotypicFeature	Abnormal macrophage count	An anomaly in the number of macrophages.	UMLS:C4022509	hp.json		http://purl.obolibrary.org/obo/HP_0030326		
HP:0032987	biolink:PhenotypicFeature	Elevated bronchoalveolar lavage fluid eosinophil proportion	Usually, eosinophils make up less than 0.5% of all cells found in the broncho-alveloar lavage fluid. But in eosinophilic lung disease, the eosinophil cell proportion typically represents more than 25%. Comment: An elevated level of eosinophil cells are also a result of infections, or an allergic reaction or can be drug-induced.		hp.json		http://purl.obolibrary.org/obo/HP_0032987		
HP:0005396	biolink:PhenotypicFeature	Susceptibility to coronavirus 229e	Increased susceptibility to coronavirus 229e, as manifested by recurrent episodes of coronavirus 229e.	UMLS:C1852539	hp.json		http://purl.obolibrary.org/obo/HP_0005396		
HP:0005397	biolink:PhenotypicFeature	obsolete Exaggerated cellular immune processes			hp.json		http://purl.obolibrary.org/obo/HP_0005397		
OBO:MAXO_0000581	biolink:NamedThing	calcium assessment	A quantitative measurement of the amount of calcium present in a sample, usually serum or urine.	NCIT:C64488	hp.json	calcium measurement	http://purl.obolibrary.org/obo/MAXO_0000581		
OBO:MAXO_0000582	biolink:NamedThing	electrolyte assessment	A quantitative measurement of the amount of an electrolyte present in urine or serum.	NCIT:C74946	hp.json	electrolyte measurement	http://purl.obolibrary.org/obo/MAXO_0000582		
OBO:MAXO_0000580	biolink:NamedThing	anion gap assessment	The determination of the unmeasured anions (those other than the chloride and bicarbonate anions) present in a sample.	NCIT:C74685	hp.json	anion gap measurement testing	http://purl.obolibrary.org/obo/MAXO_0000580		
OBO:MAXO_0000585	biolink:NamedThing	microbial culture procedure	Any laboratory procedure for growing microorganisms.	NCIT:C25300	hp.json		http://purl.obolibrary.org/obo/MAXO_0000585		
OBO:MAXO_0000583	biolink:NamedThing	serum electrolyte assessment	A quantitative measurement of the amount of an electrolyte present in serum.		hp.json	serum electrolyte measurement|electrolytes- serum testing	http://purl.obolibrary.org/obo/MAXO_0000583		
OBO:MAXO_0000584	biolink:NamedThing	urine eletrolyte assessment	A quantitative measurement of the amount of an electrolyte present in urine.		hp.json	urine eletrolyte measurement|electrolytes- urine testing	http://purl.obolibrary.org/obo/MAXO_0000584		
HP:0007949	biolink:PhenotypicFeature	obsolete Progressive macular scarring			hp.json		http://purl.obolibrary.org/obo/HP_0007949		
HP:0032913	biolink:PhenotypicFeature	Focal aware pedal automatism seizure	A type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset and during which awareness is fully retained throughout. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs.		hp.json		http://purl.obolibrary.org/obo/HP_0032913		
HP:0007946	biolink:PhenotypicFeature	Unilateral narrow palpebral fissure	A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures on one side only.	UMLS:C4280419|UMLS:C1866805	hp.json	Narrow palpebral fissure, unilateral|Unequal size of opening between the eyelids	http://purl.obolibrary.org/obo/HP_0007946		
HP:0007945	biolink:PhenotypicFeature	obsolete Choroidal degeneration			hp.json		http://purl.obolibrary.org/obo/HP_0007945		
HP:0032912	biolink:PhenotypicFeature	Focal aware manual automatism seizure	A type of focal automatism seizure characterized by manual automatisms at onset and during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032912		
HP:0032915	biolink:PhenotypicFeature	Focal aware vocal automatism seizure	A type of focal automatism seizure characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset and during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032915		
HP:0007948	biolink:PhenotypicFeature	Dense posterior cortical cataract	A type of posterior cortical cataract characterized by dense lenticular opacities.	UMLS:C4024767	hp.json		http://purl.obolibrary.org/obo/HP_0007948		
HP:0007947	biolink:PhenotypicFeature	Pericentral retinitis pigmentosa	A subtype of retinitis pigmentosa in which, instead of the pathology starting in the mid-periphery like typical retinitis pigmentosa, the disease starts in the near periphery closer to the vascular arcades and tends to spare the far periphery.	MSH:C564838|UMLS:C1849398	hp.json		http://purl.obolibrary.org/obo/HP_0007947		
HP:0032914	biolink:PhenotypicFeature	Focal aware perseverative automatism seizure	A type of focal automatism seizure characterized by inappropriate continuation of pre-seizure movement or behavior at onset and during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032914		
HP:0007942	biolink:PhenotypicFeature	Internal ophthalmoplegia	Paralysis of the iris and ciliary apparatus.	MSH:D009886|UMLS:C0339693|SNOMEDCT_US:232146005	hp.json		http://purl.obolibrary.org/obo/HP_0007942		
HP:0007941	biolink:PhenotypicFeature	Limited extraocular movements	Limited mobility of the eye within its socket.	UMLS:C1858427	hp.json	Limited extraocular movement	http://purl.obolibrary.org/obo/HP_0007941		
HP:0007944	biolink:PhenotypicFeature	Intermittent microsaccadic pursuits		UMLS:C4024768	hp.json		http://purl.obolibrary.org/obo/HP_0007944		
HP:0032911	biolink:PhenotypicFeature	Focal aware orofacial automatism seizure	A type of focal automatism seizure characterized by orofacial automatisms at onset and during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032911		
HP:0007943	biolink:PhenotypicFeature	Congenital stapes ankylosis	A form of stapes ankylosis with congenital onset.	UMLS:C1866657	hp.json		http://purl.obolibrary.org/obo/HP_0007943		
HP:0032910	biolink:PhenotypicFeature	Focal aware automatism seizure	A type of focal automatism seizure during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032910		
OBO:MAXO_0000589	biolink:NamedThing	nucleic acid amplification testing	A  tecnique that uses an amplification of nucleic acids  to detect a pathogen.  Some amplification methods include polymerase chain reaction (PCR), strand displacement assay (SDA), or transcription mediated assay (TMA) to detect a virus, bacteria or other pathogen.	NCIT:C20055	hp.json	NAAT|nucleic acid amplification procedure	http://purl.obolibrary.org/obo/MAXO_0000589		
OBO:MAXO_0000588	biolink:NamedThing	clinical nucleic acid testing	A technique that detects a particular nucleic acid sequence in order to identify a pathogen (organism or virus) in blood, tissue, urine, or other bodily fluids.		hp.json	nucleic acid testing|NAT	http://purl.obolibrary.org/obo/MAXO_0000588		
HP:0032917	biolink:PhenotypicFeature	Focal aware sexual automatism seizure	A type of focal automatism seizure characterized by involuntary sexual behavior at onset and during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032917		
HP:0032916	biolink:PhenotypicFeature	Focal aware verbal automatism seizure	A type of focal automatism seizure characterized by the production of single or repetitive words, phrases, or brief sentences at onset and during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032916		
HP:0032919	biolink:PhenotypicFeature	Focal aware head nodding automatism seizure	A type of focal automatism seizure characterized by involuntary head nodding at onset and during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032919		
HP:0032918	biolink:PhenotypicFeature	Focal impaired awareness orofacial automatism seizure	A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by orofacial automatisms at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032918		
OBO:MAXO_0000570	biolink:NamedThing	induced sputum collection	A technique to collect sputum by inhaling hypertonic saline through an oxygen mask in order to induce sputum.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000570		
OBO:MAXO_0000571	biolink:NamedThing	computed tomography procedure	A method of examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis.	NCIT:C17204	hp.json	CT|computerized axial tomography|CT scan|CAT scan	http://purl.obolibrary.org/obo/MAXO_0000571		
OBO:MAXO_0000574	biolink:NamedThing	medical history taking	The process of gathering information regarding a person's medical history.	NCIT:C146918	hp.json	patient assessment|medical history collection	http://purl.obolibrary.org/obo/MAXO_0000574		
OBO:MAXO_0000575	biolink:NamedThing	patient demographic characteristics assessment	Determination if a patient's background or demographic characteristics makes the patient susceptible to disease.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000575		
HP:0032924	biolink:PhenotypicFeature	Focal impaired awareness verbal automatism seizure	A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive words, phrases, or brief sentences at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032924		
HP:0007957	biolink:PhenotypicFeature	Corneal opacity	A reduction of corneal clarity.	UMLS:C0521719|MSH:D003318|SNOMEDCT_US:413921009|SNOMEDCT_US:95735008|UMLS:C0010038|SNOMEDCT_US:64634000	hp.json	Corneal clouding|Scarring or clouding of the cornea of the eye|Corneal opacities|Reduction of corneal clarity	http://purl.obolibrary.org/obo/HP_0007957		hposlim_core
HP:0032923	biolink:PhenotypicFeature	Focal impaired awareness vocal automatism seizure	A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032923		
HP:0007956	biolink:PhenotypicFeature	obsolete Bilateral choroid coloboma			hp.json		http://purl.obolibrary.org/obo/HP_0007956		
HP:0032926	biolink:PhenotypicFeature	Focal impaired awareness head nodding automatism seizure	A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary head nodding at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032926		
HP:0032925	biolink:PhenotypicFeature	Focal impaired awareness sexual automatism seizure	A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by involuntary sexual behavior at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032925		
HP:0007958	biolink:PhenotypicFeature	Optic atrophy from cranial nerve compression		UMLS:C4024763	hp.json		http://purl.obolibrary.org/obo/HP_0007958		
MPATH:596	biolink:NamedThing	pathological process	The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion.		hp.json		http://purl.obolibrary.org/obo/MPATH_596		
HP:0032920	biolink:PhenotypicFeature	Focal impaired awareness manual automatism seizure	A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by manual automatisms at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032920		
HP:0032922	biolink:PhenotypicFeature	Focal impaired awareness perseverative automatism seizure	A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by inappropriate continuation of pre-seizure movement or behavior at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032922		
MPATH:597	biolink:NamedThing	cell and tissue damage process	Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology.		hp.json		http://purl.obolibrary.org/obo/MPATH_597		
HP:0032921	biolink:PhenotypicFeature	Focal impaired awareness pedal automatism seizure	A type of focal automatism seizure in which awareness is partially or fully impaired at some point during the seizure and is characterized by coordinated bilateral or unilateral movements of the feet or legs at onset. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs.		hp.json		http://purl.obolibrary.org/obo/HP_0032921		
OBO:MAXO_0000578	biolink:NamedThing	patient environmental exposure assessment	Determination if the patient may have been exposed to something which would impact the health of the patient.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000578		
OBO:MAXO_0000579	biolink:NamedThing	blood gas assessment	A test that measures the amount of oxygen and carbon dioxide in the blood. It may also be used to determine the pH of the blood.	NCIT:C71252	hp.json	blood gas measurement testing|blood gas test|arterial blood gas measurement	http://purl.obolibrary.org/obo/MAXO_0000579		
MPATH:599	biolink:NamedThing	developmental process abnormalities	developmental process abnormalities		hp.json		http://purl.obolibrary.org/obo/MPATH_599		
OBO:MAXO_0000576	biolink:NamedThing	patient travel risk assessment	Determination if patient's travel history may impact current health.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000576		
HP:0007950	biolink:PhenotypicFeature	Peripapillary chorioretinal atrophy	Chorioretinal atrophy concentrated around the optic papilla (i.e., the optic nerve head).	UMLS:C4024765	hp.json		http://purl.obolibrary.org/obo/HP_0007950		
OBO:MAXO_0000577	biolink:NamedThing	patient travel risk questionnaire	A questionnaire designed to determine if patient's travel history may impact current health.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000577		
HP:0032928	biolink:PhenotypicFeature	Elevated CSF neurofilamant light chain	Definition: Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. Its levels increase in cerebrospinal fluid (CSF) and blood proportionally to the degree of axonal damage in a variety of neurological disorders, including inflammatory, neurodegenerative, traumatic and cerebrovascular diseases.		hp.json		http://purl.obolibrary.org/obo/HP_0032928		
HP:0032927	biolink:PhenotypicFeature	Focal impaired awareness undressing automatism seizure	A type of focal automatism in which awareness is partially or fully impaired at some point during the seizure and is seizure characterized by involuntary undressing at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032927		
HP:0032929	biolink:PhenotypicFeature	Abnormal chondrocyte morphology	Any abnormal structure of a chondrocyte, which is a polymorphic cell that forms cartilage.		hp.json		http://purl.obolibrary.org/obo/HP_0032929		
HP:0007928	biolink:PhenotypicFeature	Abnormal flash visual evoked potentials	Anomaly of the visual evoked potentials elicited by a flash stimulus, generally a flash of light subtending an angle of at least 20 degrees of the visual field and presented in a dimly lit room.	UMLS:C4024772	hp.json		http://purl.obolibrary.org/obo/HP_0007928		
HP:0007929	biolink:PhenotypicFeature	Peripheral retinal detachment	Separation of the inner layers of the retina (neural retina) from the pigment epithelium occuring near the outer limit (periphery) of the retina.	UMLS:C4024771	hp.json		http://purl.obolibrary.org/obo/HP_0007929		
HP:0007924	biolink:PhenotypicFeature	Slow decrease in visual acuity		UMLS:C3278981|UMLS:C1853141	hp.json	Decreased visual acuity, slowly progressive|Subacute deterioration of visual acuity|Slow decrease in sharpness of vision	http://purl.obolibrary.org/obo/HP_0007924		
HP:0032935	biolink:PhenotypicFeature	Posterior crocodile shagreen of the cornea	Grayish, polygonal pattern of opacities with intervening clear zones across the central cornea that resembles crocodile skin.		hp.json		http://purl.obolibrary.org/obo/HP_0032935		
HP:0007923	biolink:PhenotypicFeature	obsolete Foveal hyperplasia			hp.json		http://purl.obolibrary.org/obo/HP_0007923		
HP:0032934	biolink:PhenotypicFeature	Spontaneous cerebrospinal fluid leak	A spontaneous cerebrospinal fluid leak (SCSFL) is a spontaneous and unexplained leak of the cerebrospinal fluid from the dura surrounding either the brain (cranial leak) or spine (spinal leak).		hp.json		http://purl.obolibrary.org/obo/HP_0032934		
HP:0032937	biolink:PhenotypicFeature	Recurrent, involuntary and intrusive distressing memories	After suffering psychological trauma, people can repeatedly experience sensory-perceptual impressions of the event, which intrude involuntarily into consciousness. These intrusive memories typically take the form of visual images (e.g., pictures in the mind's eye), but can also include sounds, smells, tastes and bodily sensations, and come with a range of negative emotions associated with the hotspots in the trauma memory.		hp.json		http://purl.obolibrary.org/obo/HP_0032937		
HP:0007925	biolink:PhenotypicFeature	Lacrimal duct aplasia	A congenital defect resulting in absence of the lacrimal duct.	UMLS:C4024773	hp.json	Absent tear duct	http://purl.obolibrary.org/obo/HP_0007925		
HP:0032936	biolink:PhenotypicFeature	Intrusion symptom	Unintentional reexperiencing a traumatic event comprising symptoms are usually sensory impressions and emotional responses from the trauma that appear to lack a time perspective and a context.		hp.json	Re-experiencing symptom	http://purl.obolibrary.org/obo/HP_0032936		
HP:0032931	biolink:PhenotypicFeature	obsolete Focal impaired awareness cognitive seizure with impaired attention			hp.json		http://purl.obolibrary.org/obo/HP_0032931		
HP:0007920	biolink:PhenotypicFeature	obsolete Congenital chorioretinal dystrophy			hp.json		http://purl.obolibrary.org/obo/HP_0007920		
HP:0032930	biolink:PhenotypicFeature	Lacunar halos around chondrocytes	Concentric rings around the chondrocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0032930		
HP:0007922	biolink:PhenotypicFeature	Hypermyelinated retinal nerve fibers		UMLS:C1849151	hp.json	Retinal striation|Hypermyelinated retinal nerve fibres	http://purl.obolibrary.org/obo/HP_0007922		
HP:0032933	biolink:PhenotypicFeature	Airway hyperresponsiveness	An increased sensitivity of the airways to an inhaled constrictor agonist, a steeper slope of the dose-response curve, and a greater maximal response to the agonist.		hp.json		http://purl.obolibrary.org/obo/HP_0032933		
HP:0032932	biolink:PhenotypicFeature	Increased circulating pancreatic triacylglycerol lipase level	An increased level of triacylglycerol lipase in the blood circulation (can be measured in serum or plasma).		hp.json	Elevated circulating pancreatic triacylglycerol lipase activity	http://purl.obolibrary.org/obo/HP_0032932		
NCBITaxon:33630	biolink:OrganismalEntity	Alveolata		GC_ID:1	hp.json	alveolates	http://purl.obolibrary.org/obo/NCBITaxon_33630		
HP:0032939	biolink:PhenotypicFeature	Physiological reactivity to cues	Marked physiological reactions to internal or external cues that symbolize or resemble an aspect of the traumatic event(s).		hp.json		http://purl.obolibrary.org/obo/HP_0032939		
HP:0032938	biolink:PhenotypicFeature	Recurrent trauma-related distressing dreams	Recurrent distressing dreams in which the content and/or affect of the dream are related to the traumatic event or events.		hp.json		http://purl.obolibrary.org/obo/HP_0032938		
OBO:MAXO_0000592	biolink:NamedThing	clinical RNA detection testing	A technique that detects a particular RNA sequence in order to identify a pathogen (organism or virus) in blood, tissue, urine, or other bodily fluids.		hp.json	RNA detection procedure|RNA detection examination|RNA detection testing|RNA detection kit testing	http://purl.obolibrary.org/obo/MAXO_0000592		
OBO:MAXO_0000593	biolink:NamedThing	clinical real-time PCR testing	A clinical assay that amplifies and quantifies a specific DNA molecule based on in tissue, blood, sputum, urine, or any other bodily fluid to detect the presence of a pathogen.  It enables both detection and quantification of one or more specific sequences in a DNA sample.	OBI:0000893|NCIT:C51962	hp.json	clinical qPCR testing|clinical real-time RT-PCR procedure|real-time PCR procedure for clinical use	http://purl.obolibrary.org/obo/MAXO_0000593		
UBERON:0015482	biolink:AnatomicalEntity	right hepatic artery	A hepatic artery that is part of a right lobe of liver.	FMA:14778|MA:0003097|EMAPA:37376	hp.json	ramus dexter (arteria hepatica propria)|right branch of hepatic artery proper|right part of hepatic artery proper	http://purl.obolibrary.org/obo/UBERON_0015482		human_reference_atlas
OBO:MAXO_0000590	biolink:NamedThing	loop-mediated isothermal amplification testing	A type of nucleic acid amplification test in which sample DNA is exposed to a single temperature in the presence of multiple sets of primers and a polymerase with replication and high strand displacement activity. This test negates the need for thermal cyclers and may be a low cost alternative to PCR.	NCIT:C102661	hp.json	loop-mediated isothermal amplification procedure	http://purl.obolibrary.org/obo/MAXO_0000590		
UBERON:0015485	biolink:AnatomicalEntity	choledocho-duodenal junction	Hat part of the duodenal wall traversed by the ductus choledochus, ductus pancreaticus, and ampulla.	MA:0003108|EMAPA:37478	hp.json	choledochoduodenal junction	http://purl.obolibrary.org/obo/UBERON_0015485		
OBO:MAXO_0000591	biolink:NamedThing	clinical DNA detection testing	A technique that detects a particular DNA sequence in order to identify a pathogen (organism or virus) in blood, tissue, urine, or other bodily fluids.		hp.json	DNA detection procedure|DNA detection examination|DNA detection testing|DNA detection kit testing	http://purl.obolibrary.org/obo/MAXO_0000591		
OBO:MAXO_0000596	biolink:NamedThing	infectious disease screening	The process of taking a thorough history and physical exam to determine if a patient has been exposed to an infectious disease.  Close attention is paid to travel history, environmental exposures, and vaccination history.		hp.json	infectious disease testing	http://purl.obolibrary.org/obo/MAXO_0000596		
UBERON:0015481	biolink:AnatomicalEntity	left hepatic artery	A hepatic artery that is part of a left lobe of liver.	EMAPA:37096|FMA:14779|MA:0003096	hp.json	ramus sinister (arteria hepatica propria)|left part of hepatic artery proper|left branch of hepatic artery	http://purl.obolibrary.org/obo/UBERON_0015481		human_reference_atlas
OBO:MAXO_0000594	biolink:NamedThing	clinical quantitative reverse transcription PCR testing	A method to measure very small amounts of RNA transcripts as cDNA targets from tissue, blood, sputum or other body fluids.	NCIT:C28408|OBI:0000911	hp.json	clinical quantitative RT-PCR testing|clinical quantitative reverse transcription PCR procedure|clinical quantitative RT-PCR procedure	http://purl.obolibrary.org/obo/MAXO_0000594		
UBERON:0015480	biolink:AnatomicalEntity	proper hepatic artery	The hepatic artery proper (also proper hepatic artery), arises from the common hepatic artery and runs alongside the portal vein and the common bile duct to form the portal triad. The hepatic artery proper gives off a small supraduodenal artery to the duodenal bulb. Then the right gastric artery comes off and runs to the left along the lesser curvature of the stomach to meet the left gastric artery, which is a branch of the celiac trunk. It subsequently gives off the cystic artery, which feeds the gallbladder, before bifurcating into the right and left hepatic arteries. Of note, the right and left hepatic arteries may demonstrate variant anatomy. A replaced right hepatic artery may arise from the superior mesenteric artery (SMA) and a replaced left hepatic artery may arise from the left gastric artery.	FMA:14772|EMAPA:37217|MA:0003095	hp.json	proper hepatic|hepatic artery proper	http://purl.obolibrary.org/obo/UBERON_0015480		human_reference_atlas
OBO:MAXO_0000595	biolink:NamedThing	radiograph imaging procedure	A procedure producing an image on a radiosensitive surface by x-ray radiation that has penetrated and passed through a structure in order to diagnose or treat a patient.	NCIT:C60727|NCIT:C38101	hp.json	radiography imaging procedure|X-ray imaging procedure|radiographic procedure|radiogram imaging procedure|radiographic imaging procedure|radiography	http://purl.obolibrary.org/obo/MAXO_0000595		
HP:0032940	biolink:PhenotypicFeature	Dissociative reaction	A disruption and/or discontinuity in the normal integration of consciousness, memory, identity, emotion, perception, body representation, motor control, and behavior. Clinical presentations of dissociation may include a wide variety of symptoms, including experiences of depersonalization, derealisation, emotional numbing, flashbacks of traumatic events, absorption, amnesia, voice hearing, interruptions in awareness, and identity alteration.		hp.json		http://purl.obolibrary.org/obo/HP_0032940		
HP:0007939	biolink:PhenotypicFeature	Blue cone monochromacy	A form of monochromacy in which vision is derived from the remaining preserved blue (S) cones and rod photoreceptors.	MSH:C536238|UMLS:C0339537|SNOMEDCT_US:24704003	hp.json	Blue cone monochromatism|Incomplete achromatopsia|S-cone monochromacy	http://purl.obolibrary.org/obo/HP_0007939		
HP:0032946	biolink:PhenotypicFeature	Renal cortical interstitial inflammation	Histopathological findings of inflammation of the renal interstitium involving fibrotic as well as non-fibrotic renal cortex, composed of lymphocytes, monocytes, plasma cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032946		
HP:0007935	biolink:PhenotypicFeature	Juvenile posterior subcapsular lenticular opacities		UMLS:C1863408	hp.json		http://purl.obolibrary.org/obo/HP_0007935		
HP:0032945	biolink:PhenotypicFeature	Renal interstitial inflammation	Histopathological findings of inflammation of the renal interstitium potentially involving fibrotic as well as non-fibrotic areas, composed of lymphocytes, monocytes, plasma cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032945		
HP:0007937	biolink:PhenotypicFeature	Reticular pigmentary degeneration	A type of retinal reticular pigmentation that forms a polygonal, netlike arrangement of hyperpigmented lines forming geometric patterns in the fundus.	UMLS:C4024769	hp.json	Honeycomb retinal degeneration|Fishnet retinal pigmentation	http://purl.obolibrary.org/obo/HP_0007937		
HP:0032948	biolink:PhenotypicFeature	Renal interstitial fibrosis	The accumulation of collagen and related extracellular matrix (ECM) molecules in the interstitium of the kidney. The interstitium is expanded by the presence of collagen that stain blue on trichrome. Tubules are not back to back, but rather separated by fibrosis and can be atrophic.		hp.json		http://purl.obolibrary.org/obo/HP_0032948		
HP:0007936	biolink:PhenotypicFeature	Restrictive external ophthalmoplegia	Fibrosis of the external ocular muscles such that the eyes of affected individuals are partially or completely fixed in a strabismic position. Residual eye movements are significantly limited.	UMLS:C4020806|UMLS:C1865918	hp.json	Restrictive external ophthalmoplegia, bilateral|Restrictive ophthalmoplegia	http://purl.obolibrary.org/obo/HP_0007936		
HP:0032947	biolink:PhenotypicFeature	Renal medullary interstitial inflammation	Histopathological findings of inflammation of the interstitium of the renal medulla, composed of lymphocytes, monocytes, plasma cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032947		
HP:0032942	biolink:PhenotypicFeature	Avoidance of stimuli associated with traumatic event	Avoidance of or efforts to avoid distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s). Avoidance of or efforts to avoid external reminders (people, places, conversations, activities, objects, situations) that arouse distressing memories, thoughts, or feelings about or closely associated with the traumatic event(s).		hp.json		http://purl.obolibrary.org/obo/HP_0032942		
MPATH:574	biolink:NamedThing	nephroblastomatosis	Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests.		hp.json		http://purl.obolibrary.org/obo/MPATH_574		
HP:0032941	biolink:PhenotypicFeature	Intense psychological distress to cues	Intense or prolonged psychological distress at exposure to internal or external cues that symbolize or resemble an aspect of the traumatic event or events.		hp.json		http://purl.obolibrary.org/obo/HP_0032941		
HP:0007930	biolink:PhenotypicFeature	obsolete Prominent epicanthal folds			hp.json		http://purl.obolibrary.org/obo/HP_0007930		
HP:0007933	biolink:PhenotypicFeature	Broad lateral eyebrow	Regional increase in the width (height) of the lateral eyebrow.	UMLS:C1837733	hp.json	Wide lateral eyebrow	http://purl.obolibrary.org/obo/HP_0007933		
HP:0032944	biolink:PhenotypicFeature	Alkaline urine	Urine pH of 8 or higher.		hp.json		http://purl.obolibrary.org/obo/HP_0032944		
HP:0007932	biolink:PhenotypicFeature	Bilateral congenital mydriasis	Congenital abnormal dilation of the pupil on both sides.	UMLS:C4024770	hp.json		http://purl.obolibrary.org/obo/HP_0007932		
HP:0032943	biolink:PhenotypicFeature	Abnormal urine pH	A deviation of urine pH from the normal range of 4.5 to 7.8.		hp.json		http://purl.obolibrary.org/obo/HP_0032943		
MPATH:579	biolink:NamedThing	ulcer	Loss of epithelium and the basement membrane (full thickness). Cf Erosion.		hp.json		http://purl.obolibrary.org/obo/MPATH_579		
HP:0032949	biolink:PhenotypicFeature	Renal interstitial calcium phosphate deposits	The presence of interstitial aggregates of purple finely granular/laminated calcium- and phosphate deposits.		hp.json		http://purl.obolibrary.org/obo/HP_0032949		
OBO:MAXO_0000541	biolink:NamedThing	quad test assessment	A screening measurement in which the maternal blood levels of alpha-fetoprotein, unconjugated estriol, human chorionic gonadotrophin and Inhibin A are calculated. These are then evaluated in relation to the mother's age, weight and fetal gestational age.	NCIT:C92865	hp.json	quad screen|quadruple marker testing	http://purl.obolibrary.org/obo/MAXO_0000541		
OBO:MAXO_0000540	biolink:NamedThing	nuchal translucency screening	An ultrasonic examination of the fetus in the late first trimester to measure the clear space at the back of the fetal neck to assess risk of genetic or cardiac abnormalities.	NCIT:C92837	hp.json	ultrasonographic nuchal translucency exam|NT testing|nuchal translucency ultrasound screening	http://purl.obolibrary.org/obo/MAXO_0000540		
HP:0005327	biolink:PhenotypicFeature	Loss of facial expression		UMLS:C1852476	hp.json	Loss of facial expression	http://purl.obolibrary.org/obo/HP_0005327		
HP:0005328	biolink:PhenotypicFeature	Progeroid facial appearance	A degree of wrinkling of the facial skin that is more than expected for the age of the individual, leading to a prematurely aged appearance.	UMLS:C1857710	hp.json	Prematurely aged facial appearance|Premature aged appearance|Prematurely aged face|Wizened face|Aged facial appearance	http://purl.obolibrary.org/obo/HP_0005328		
HP:0007989	biolink:PhenotypicFeature	Intraretinal exudate	Retinal exudate within the retinal tissue itself.	UMLS:C4024758	hp.json		http://purl.obolibrary.org/obo/HP_0007989		
HP:0005329	biolink:PhenotypicFeature	Fixed facial expression		UMLS:C1855353	hp.json	Fixed facial expression|Unchanging facial expression	http://purl.obolibrary.org/obo/HP_0005329		
HP:0005323	biolink:PhenotypicFeature	Hemifacial hypertrophy	Unilateral overgrowth of facial tissues, including muscles, bones and skin.	UMLS:C0016719|SNOMEDCT_US:697962004|MSH:C563014|MSH:D005621|SNOMEDCT_US:10394003|UMLS:C1399354	hp.json	Hypertrophy of half of face|Overgrowth of half of face|Facial hemihypertophy|Hemifacial enlargement|Friedreich's disease|Facial hemihyperplasia|Enlargement of half of face|Increase in size of half of face	http://purl.obolibrary.org/obo/HP_0005323		hposlim_core
HP:0007986	biolink:PhenotypicFeature	Increased retinal vascularity		UMLS:C1847882	hp.json		http://purl.obolibrary.org/obo/HP_0007986		
HP:0007985	biolink:PhenotypicFeature	Retinal arteriolar occlusion	Blockage of retinal arteriole, generally associated with interruption of blood flow and oxygen delivery to affected regions of the retina.	UMLS:C4024761	hp.json	Blocked retinal artery	http://purl.obolibrary.org/obo/HP_0007985		
HP:0005324	biolink:PhenotypicFeature	Disturbance of facial expression	An abnormality of the gestures or movements executed with the facial muscles with which emotions such as fear, joy, sadness, surprise, and disgust can be expressed.	UMLS:C4025215	hp.json	Disturbance of facial expression	http://purl.obolibrary.org/obo/HP_0005324		
HP:0007988	biolink:PhenotypicFeature	Macular hypopigmentation	Decreased amount of pigmentation in the macula lutea.	UMLS:C4024759	hp.json		http://purl.obolibrary.org/obo/HP_0007988		
HP:0005325	biolink:PhenotypicFeature	Extension of hair growth on temples to lateral eyebrow	A pattern of hair growth in which there is hair extending from the temples to the lateral eyebrows.	UMLS:C1857455	hp.json	Unusual hairline with hair growth on temples extending to lateral eyebrow	http://purl.obolibrary.org/obo/HP_0005325		
HP:0005326	biolink:PhenotypicFeature	Hypoplastic philtrum	Underdevelopment of the philtrum.	UMLS:C1856886	hp.json	Small philtrum	http://purl.obolibrary.org/obo/HP_0005326		
HP:0007987	biolink:PhenotypicFeature	Progressive visual field defects		UMLS:C4024760	hp.json		http://purl.obolibrary.org/obo/HP_0007987		
OBO:MAXO_0000545	biolink:NamedThing	basophil count	The determination of the absolute number of basophils in a blood sample.	NCIT:C64470	hp.json	basophil cell count|total basophil count	http://purl.obolibrary.org/obo/MAXO_0000545		
HP:0007982	biolink:PhenotypicFeature	obsolete Central tapetoretinal dystrophy			hp.json		http://purl.obolibrary.org/obo/HP_0007982		
OBO:MAXO_0000546	biolink:NamedThing	lymphocyte count	The determination of the number of lymphocytes in a blood sample.	NCIT:C51949	hp.json		http://purl.obolibrary.org/obo/MAXO_0000546		
HP:0005320	biolink:PhenotypicFeature	Lack of facial subcutaneous fat		UMLS:C3277426	hp.json	Lack of facial fat below the skin	http://purl.obolibrary.org/obo/HP_0005320		
HP:0007981	biolink:PhenotypicFeature	obsolete Concentric narrowing of visual field			hp.json		http://purl.obolibrary.org/obo/HP_0007981		
OBO:MAXO_0000543	biolink:NamedThing	eosinophil count	The determination of the number of eosinophils in a blood sample.	NCIT:C64550	hp.json	EOS cell count	http://purl.obolibrary.org/obo/MAXO_0000543		
HP:0007984	biolink:PhenotypicFeature	Electronegative electroretinogram	A dark-adapted bright flash electroretinogram in which the b-wave that is of markedly lower amplitude than the associated a-wave (source: Holder GE., Inherited Chorioretinal Dystrophies: A Textbook and Atlas; 2014; p.17; ISBN 978-3-540-69466-3).	UMLS:C4021561	hp.json	Reduced electroretinogram rod b-wave|Reduced amplitude of dark-adapted bright flash electroretinogram b-wave|Electroretinogram: reduced b-wave amplitude|Reduced ERG amplitude of b-wave|Electronegative ERG	http://purl.obolibrary.org/obo/HP_0007984		
HP:0005321	biolink:PhenotypicFeature	Mandibulofacial dysostosis	A type of craniofacial dysostosis associated with abnormalities of the external ears, mirognathia, macrostomia, coloboma of the lower eyelid, and cleft palate. This is a bundled term that is left in the HPO now for convenience with legacy annotations but should not be used for new annotations.	SNOMEDCT_US:82203000|UMLS:C0242387|MSH:D008342	hp.json	Treacher Collins syndrome	http://purl.obolibrary.org/obo/HP_0005321		
HP:0005322	biolink:PhenotypicFeature	Prominent nasal septum		UMLS:C4025216|UMLS:C4280490|UMLS:C4280489	hp.json	Visible septum of nose|Low hanging septum of nose|Prominent nasal septum|Visible nasal septum|Low hanging nasal septum|Prominent septum of nose	http://purl.obolibrary.org/obo/HP_0005322		
OBO:MAXO_0000544	biolink:NamedThing	granulocyte count	The determination of the amount of granulocytes present in a sample.	NCIT:C96654	hp.json	polymorphonuclear leukocyte count	http://purl.obolibrary.org/obo/MAXO_0000544		
OBO:MAXO_0000549	biolink:NamedThing	self body temperature measurement	Measuring a person's own body temperature usually at home using any of a number of types of thermometers.		hp.json	self-reported fever measurement|self-reported temperature measurement|at home temperature measurement	http://purl.obolibrary.org/obo/MAXO_0000549		
OBO:MAXO_0000547	biolink:NamedThing	clinical biospecimen collection	A procedure by which biological material is obtained from a subject for testing, diagnostic, treatment, or research purposes.	NCIT:C70700	hp.json	clinical specimen collection	http://purl.obolibrary.org/obo/MAXO_0000547		
HP:0007980	biolink:PhenotypicFeature	Absent retinal pigment epithelium		UMLS:C1852548	hp.json		http://purl.obolibrary.org/obo/HP_0007980		
NCBITaxon:33682	biolink:OrganismalEntity	Euglenozoa		GC_ID:1	hp.json	Euglenozoans	http://purl.obolibrary.org/obo/NCBITaxon_33682		
OBO:MAXO_0000530	biolink:NamedThing	genetic carrier screening	A genetic test to whether a healthy person harbors a recessive mutation in one of their copies of a gene or genes.		hp.json	carrier screening	http://purl.obolibrary.org/obo/MAXO_0000530		
OBO:MAXO_0000531	biolink:NamedThing	noninvasive prenatal testing	A test that analyzes small fragments of DNA that are circulating in a pregnant woman’s blood to determine the risk that the fetus will be born with genetic abnormalities.		hp.json	NIPT|cell free fetal DNA testing|noninvasive prenatal screening	http://purl.obolibrary.org/obo/MAXO_0000531		
HP:0005338	biolink:PhenotypicFeature	Sparse lateral eyebrow	Decreased density/number and/or decreased diameter of lateral eyebrow hairs.	UMLS:C1857206	hp.json	Laterally sparse eyebrow|Lateral hypoplasia of eyebrows|Sparse lateral eyebrows|Laterally sparse eyebrows|Lateral thinning of eyebrows|Limited hair on end of eyebrow	http://purl.obolibrary.org/obo/HP_0005338		hposlim_core
HP:0005339	biolink:PhenotypicFeature	Abnormality of complement system	An abnormality of the complement system.	UMLS:C4025213	hp.json		http://purl.obolibrary.org/obo/HP_0005339		
HP:0005335	biolink:PhenotypicFeature	Sleepy facial expression		UMLS:C4025214	hp.json	Sleepy facial expression|Somnolent facial expression	http://purl.obolibrary.org/obo/HP_0005335		
HP:0005336	biolink:PhenotypicFeature	Forehead hyperpigmentation		UMLS:C1969673	hp.json	Darkening of the forehead	http://purl.obolibrary.org/obo/HP_0005336		
HP:0007993	biolink:PhenotypicFeature	Malformed lacrimal duct	Congenital malformation of the lacrimal duct associated with incomplete development of the bony nasolacrimal canal or craniofacial anomalies.	UMLS:C4024757	hp.json	Malformed tear ducts	http://purl.obolibrary.org/obo/HP_0007993		
MPATH:556	biolink:NamedThing	potentially cancerous lesions	Lesions which in some cases have the potential to become progressively growing malignant tumors.		hp.json		http://purl.obolibrary.org/obo/MPATH_556		
OBO:MAXO_0000534	biolink:NamedThing	amniocentisis	A prenatal diagnostic procedure in which a small sample of amniotic fluid is removed from the uterus by a needle inserted into the abdomen. This procedure is used to detect various genetic abnormalities in the fetus and/or the sex of the fetus.	NCIT:C52009	hp.json		http://purl.obolibrary.org/obo/MAXO_0000534		
MPATH:555	biolink:NamedThing	mineralisation	Deposition of any homogeneous inorganic material.		hp.json		http://purl.obolibrary.org/obo/MPATH_555		
HP:0007992	biolink:PhenotypicFeature	Lattice retinal degeneration		SNOMEDCT_US:3577000|UMLS:C0154856	hp.json		http://purl.obolibrary.org/obo/HP_0007992		
HP:0005332	biolink:PhenotypicFeature	Recurrent mandibular subluxations	Recurrent partial dislocations of the mandible.	UMLS:C1857011	hp.json		http://purl.obolibrary.org/obo/HP_0005332		
HP:0007994	biolink:PhenotypicFeature	Peripheral visual field loss	Loss of peripheral vision with retention of central vision, resulting in a constricted circular tunnel-like field of vision.	UMLS:C0241688|SNOMEDCT_US:420990001|UMLS:C2937228	hp.json	Tunnel vision|Loss of peripheral vision|Kalnienk vision	http://purl.obolibrary.org/obo/HP_0007994		
OBO:MAXO_0000533	biolink:NamedThing	molecular genetic testing	A diverse set of techniques used to identify the molecular basis of genetic disease. Examples of molecular genetic tests include: genotyping to detect specific pathogenic variants; sequencing of a gene to detect pathogenic variants; amplification or hybridization methods (e.g., qPCR, array CGH, MLPA) to detect copy number variants involving one or more genes; methylation-specific techniques to detect epigenetic changes that influence gene expression; and exome and genome sequencing.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000533		
OBO:MAXO_0000538	biolink:NamedThing	fetal fibronectin testing	A test for the presence of fetal fibronectin in the cervico-vaginal area that is used to predict preterm birth.	NCIT:C92786	hp.json	FBNCTFT|fFN testing|fetal fibronectin assessment	http://purl.obolibrary.org/obo/MAXO_0000538		
OBO:MAXO_0000539	biolink:NamedThing	prenatal group B streptococcus screening	Screening with a swab from the vaginal and rectal areas in late pregnancy to test for the presence of Group B streptococcal infection.	NCIT:C92805	hp.json	beta-hemolytic strep culture screening|GBS|group B strep screening|broup B Beta-hemolytic streptococcus screening	http://purl.obolibrary.org/obo/MAXO_0000539		
OBO:MAXO_0000536	biolink:NamedThing	chorionic villus sampling	A prenatal test in which a sample of chorionic villi is removed from the placenta for testing. The sample can be taken through the cervix (transcervical) or the abdominal wall (transabdominal). Mayo Clinic	NCIT:C92755	hp.json	CVS|chorionic villus biopsy	http://purl.obolibrary.org/obo/MAXO_0000536		
OBO:MAXO_0000537	biolink:NamedThing	bacterial vaginosis screening	A procedure conducted during pregnancy for the presence of Gardnerella vaginalis, Ureaplasma urealyticum, Mycoplasma hominis, Mobiluncus, Prevotella and anaerobic bacteria.	NCIT:C92740	hp.json	BV testing	http://purl.obolibrary.org/obo/MAXO_0000537		
HP:0007990	biolink:PhenotypicFeature	Hypoplastic iris stroma	Underdevelopment of the stroma of iris.	UMLS:C1860344	hp.json	Underdeveloped iris stroma|Iris stromal hypoplasia|Hypoplastic iris stoma	http://purl.obolibrary.org/obo/HP_0007990		
OBO:MAXO_0000560	biolink:NamedThing	interferon-gamma biomarker measurement	Detection of interferon-gamma, a cytokine that indicates an inflammatory response.		hp.json	INF-gamma levels testing|INF-gamma assessment	http://purl.obolibrary.org/obo/MAXO_0000560		
OBO:MAXO_0000563	biolink:NamedThing	Interleukin-10 biomarker measurement	Detection of interleukin-10, a cytokine identified as an inflammation suppressant.		hp.json	IL-10 measurement|IL10 assessment|IL-10 testing	http://purl.obolibrary.org/obo/MAXO_0000563		
OBO:MAXO_0000564	biolink:NamedThing	tumor necrosis factor-beta biomarker measurement	Detection of tumor necrosis factor-beta (TNF-beta), a cytokine identified as an inflammation suppressant.		hp.json	TNFbeta assessment|TNF-beta testing|TNF-beta measurement	http://purl.obolibrary.org/obo/MAXO_0000564		
OBO:MAXO_0000561	biolink:NamedThing	interleukin-4 biomarker measurement	Detection of interleukin-4, a cytokine identified as an inflammation suppressant.		hp.json	IL-4 measurement|IL4 assessment|IL-4 testing	http://purl.obolibrary.org/obo/MAXO_0000561		
OBO:MAXO_0000562	biolink:NamedThing	interleukin-5 biomarker measurement	Detection of interleukin-5, a cytokine identified as an inflammation suppressant.		hp.json	IL5 assessment|IL-5 testing|IL-5 measurement	http://purl.obolibrary.org/obo/MAXO_0000562		
HP:0005309	biolink:PhenotypicFeature	obsolete Peripheral vascular insufficiency			hp.json		http://purl.obolibrary.org/obo/HP_0005309		
HP:0007968	biolink:PhenotypicFeature	Remnants of the hyaloid vascular system	Persistence of the hyaloid artery, which is the embryonic artery that runs from the optic disk to the posterior lens capsule may persist; the site of attachment may form an opacity. The hyaloid artery is a branch of the ophthalmic artery, and usually regresses completely before birth. This features results from a failure of regression of the hyaloid vessel, which supplies the primary vitreous during embryogenesis and normally regresses in the third trimester of pregnancy, leading to a particular form of posterior cataract.	MSH:D054514|SNOMEDCT_US:44647001|UMLS:C0266568|SNOMEDCT_US:69927002|SNOMEDCT_US:314270008	hp.json	Persistent hyperplastic primary vitreous|Persistent hyperplasia of primary vitreous|Congenital retinal septum|Persistent hypertrophic primary vitreous|Persistent posterior fetal fibrovascular sheath of the lens|Persistent fetal vasculature|Persistent posterior foetal fibrovascular sheath of the lens|Persistent foetal vasculature|Persistent tunica vasculosa lentis	http://purl.obolibrary.org/obo/HP_0007968		hposlim_core
HP:0005305	biolink:PhenotypicFeature	Cerebral venous thrombosis	Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow.	SNOMEDCT_US:95455008|UMLS:C0151945	hp.json	Cerebral thrombosis|Cerebral vein thrombosis|Blood clot in cerebral vein	http://purl.obolibrary.org/obo/HP_0005305		
HP:0005306	biolink:PhenotypicFeature	Capillary hemangioma	The presence of a capillary hemangioma, which are hemangiomas with small endothelial spaces.	UMLS:C0206733|SNOMEDCT_US:254206003|SNOMEDCT_US:56975005|SNOMEDCT_US:83343001|SNOMEDCT_US:195382003|SNOMEDCT_US:402867006|MSH:D018324	hp.json	Strawberry birthmark|Capillary hemangiomata	http://purl.obolibrary.org/obo/HP_0005306		hposlim_core
HP:0005307	biolink:PhenotypicFeature	Postural hypotension with compensatory tachycardia		UMLS:C1850438	hp.json		http://purl.obolibrary.org/obo/HP_0005307		
HP:0005308	biolink:PhenotypicFeature	Pulmonary artery vasoconstriction		UMLS:C1867424	hp.json		http://purl.obolibrary.org/obo/HP_0005308		
HP:0007964	biolink:PhenotypicFeature	Degenerative vitreoretinopathy		UMLS:C1843486	hp.json		http://purl.obolibrary.org/obo/HP_0007964		
HP:0005301	biolink:PhenotypicFeature	Persistent left superior vena cava	A rare congenital vascular anomaly that results when the left superior cardinal vein caudal to the innominate vein fails to regress.	SNOMEDCT_US:77978002|UMLS:C0265931	hp.json	PLSVC	http://purl.obolibrary.org/obo/HP_0005301		
HP:0005302	biolink:PhenotypicFeature	Carotid artery tortuosity	Abnormal tortuous (i.e., twisted) form of the carotid arteries.	SNOMEDCT_US:401051003|UMLS:C1303076	hp.json	Tortuous carotid arteries	http://purl.obolibrary.org/obo/HP_0005302		
HP:0007963	biolink:PhenotypicFeature	Pattern dystrophy of the retina	A spectrum of fundoscopic appearances characterized by the development of a variety of patterns of deposits predominantly in the macular area. The deposits are typically bilateral, relatively symmetrical, yellow/white and associated with changes at the level of the retinal pigment epithelium. With time, retinal atrophy may occur. A number of pattern dystrophy subtypes have been described including butterfly-shaped dystrophy, reticular dystrophy (net-like pattern) and fundus pulverulentus (granular, mottled pigmentation).	UMLS:C4024762	hp.json		http://purl.obolibrary.org/obo/HP_0007963		
HP:0005303	biolink:PhenotypicFeature	Aortic arch calcification	Calcification, that is, pathological deposition of calcium salts in the arch of aorta.	UMLS:C1969291	hp.json		http://purl.obolibrary.org/obo/HP_0005303		
HP:0007965	biolink:PhenotypicFeature	Undetectable visual evoked potentials		UMLS:C1850069	hp.json	Undetectable VEP|Absence of visual evoked potentials|Non-detectable VEP	http://purl.obolibrary.org/obo/HP_0007965		
HP:0005304	biolink:PhenotypicFeature	Hypoplastic pulmonary veins		UMLS:C1970501	hp.json	Underdeveloped lung veins	http://purl.obolibrary.org/obo/HP_0005304		
OBO:MAXO_0000567	biolink:NamedThing	blood glucose assessment	A quantitative measurement for assessing the amount of glucose present in a blood sample.	NCIT:C92744	hp.json	blood glucose testing|blood glucose measurement|blood surgar testing	http://purl.obolibrary.org/obo/MAXO_0000567		
OBO:MAXO_0000568	biolink:NamedThing	plasma glucose assessment	Glucose Plasma Concentration (GPC) measurement is an essential diagnostic modality for different types of carbohydrate metabolism derangements including diabetes mellitus.	NCIT:C41376	hp.json	plasma glucose measurement	http://purl.obolibrary.org/obo/MAXO_0000568		
OBO:MAXO_0000565	biolink:NamedThing	serum amyloid A biomarker assessment	Detection of serum levels of amyloid A (SAA) in response to inflammation.		hp.json	SAA biomarker measurement	http://purl.obolibrary.org/obo/MAXO_0000565		
HP:0007962	biolink:PhenotypicFeature	Speckled corneal dystrophy		UMLS:C4021857	hp.json		http://purl.obolibrary.org/obo/HP_0007962		
OBO:MAXO_0000566	biolink:NamedThing	clinical chemistry assessment	A clinical laboratory procedure designed for the quantification of an organic or inorganic chemical within a biological specimen required for diagnostics or monitoring of treatments.	NCIT:C49237	hp.json	clinical chemistry testing|clinical chemistry measurement testing|clincal chemistry test	http://purl.obolibrary.org/obo/MAXO_0000566		
HP:0005300	biolink:PhenotypicFeature	Nodular inflammatory vasculitis		UMLS:C4025219	hp.json		http://purl.obolibrary.org/obo/HP_0005300		
HP:0007961	biolink:PhenotypicFeature	obsolete Rarefaction of retinal pigmentation			hp.json		http://purl.obolibrary.org/obo/HP_0007961		
OBO:MAXO_0000569	biolink:NamedThing	fasting blood glucose assessment	A quantitative measurement of the amount of glucose present in a sample of blood, obtained from a source that has abstained from nutrition, typically at least 8 hours prior to the sample collection time.	NCIT:C80400	hp.json	FBS measurement|fasting blood sugar measurement testing|fasting blood glucose measurement	http://purl.obolibrary.org/obo/MAXO_0000569		
OBO:MAXO_0000552	biolink:NamedThing	interleukin-6 biomarker measurement	Detection of circultating interleukin-6, which stimulates the inflammatory and auto-immune processes in many diseases.		hp.json	IL-6 measurement|IL-6 level assessment	http://purl.obolibrary.org/obo/MAXO_0000552		
OBO:MAXO_0000553	biolink:NamedThing	cytokine biomarker assessment	A chemokine that can be objectively measured and serves as an indicator for the inflammatory response.		hp.json	cytokine biomarker measurement	http://purl.obolibrary.org/obo/MAXO_0000553		
OBO:MAXO_0000550	biolink:NamedThing	inflammatory biomarker assessment	A characteristic that can be objectively measured and serves as an indicator for the inflammatory response.  It could be used to indicate the normal inflammatory processes, pathogenic processes, state of health or disease, the risk for disease development and/or prognosis, or responsiveness to a particular therapeutic intervention.		hp.json	inflammatory biomarker measurement	http://purl.obolibrary.org/obo/MAXO_0000550		
OBO:MAXO_0000551	biolink:NamedThing	C-reactive protein biomarker assessment	Assay based assessment of a serum sample for detection and concentration (mg/L) C-reactive protein.		hp.json	CRP measurement	http://purl.obolibrary.org/obo/MAXO_0000551		
HP:0007979	biolink:PhenotypicFeature	Gaze-evoked horizontal nystagmus	Horizontal nystagmus made apparent by looking to the right or to the left.	UMLS:C1853394	hp.json	Nystagmus, horizontal gaze-evoked|Nystagmus, horizontal, gaze-evoked	http://purl.obolibrary.org/obo/HP_0007979		
HP:0032902	biolink:PhenotypicFeature	Focal perseverative automatism seizure	A type of focal automatism seizure characterized by inappropriate continuation of pre-seizure movement or behavior at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032902		
HP:0005316	biolink:PhenotypicFeature	Peripheral pulmonary vessel aplasia		UMLS:C1848877	hp.json		http://purl.obolibrary.org/obo/HP_0005316		
HP:0005317	biolink:PhenotypicFeature	Increased pulmonary vascular resistance	Pulmonary vascular resistance (PVR) more than 3 wood units, as defined by the current definition of pulmonary hypertension. 95% of individuals have a PVR of less than 2.4 wood units.	UMLS:C1867423	hp.json		http://purl.obolibrary.org/obo/HP_0005317		
HP:0032901	biolink:PhenotypicFeature	Focal pedal automatism seizure	A type of focal automatism seizure characterized by coordinated bilateral or unilateral movements of the feet or legs at onset. The movement is more reminiscent of normal movements in amplitude, and is less frenetic or rapid in comparison to the movements seen in focal hyperkinetic seizures involving the legs.		hp.json		http://purl.obolibrary.org/obo/HP_0032901		
HP:0005318	biolink:PhenotypicFeature	Cerebral vasculitis	Inflammation of the blood vessels within the brain.	UMLS:C0238051|SNOMEDCT_US:427020007|MSH:D020293	hp.json		http://purl.obolibrary.org/obo/HP_0005318		
HP:0032904	biolink:PhenotypicFeature	Focal verbal automatism seizure	A type of focal automatism seizure characterized by the production of single or repetitive words, phrases, or brief sentences at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032904		
HP:0032903	biolink:PhenotypicFeature	Focal vocal automatism seizure	A type of focal automatism seizure characterized by the production of single or repetitive meaningless vocal sounds such as shrieks or grunts at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032903		
HP:0007975	biolink:PhenotypicFeature	Hypometric horizontal saccades	Saccadic undershoot of horizontal saccadic eye movements, i.e., a horizontal saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object.	UMLS:C1856478	hp.json		http://purl.obolibrary.org/obo/HP_0007975		
HP:0005312	biolink:PhenotypicFeature	Pulmonary aterial intimal fibrosis	Formation of excess fibrous connective tissue in the tunica intima (innermost layer) of arteries in the pulmonary circulation.	UMLS:C4025217	hp.json		http://purl.obolibrary.org/obo/HP_0005312		
HP:0005313	biolink:PhenotypicFeature	Arterial fibromuscular dysplasia	An arterial lesion that is characterized by either intimal fibroplasia, with neointimal lesions of cells and matrix deposition, or medial fibroplasia, in which there is loss of smooth muscle cells and increased deposition of collagen and proteoglycans in the medial layer.	SNOMEDCT_US:31653004|SNOMEDCT_US:359553002|UMLS:C0016052|MSH:D005352	hp.json		http://purl.obolibrary.org/obo/HP_0005313		
HP:0032900	biolink:PhenotypicFeature	Focal manual automatism seizure	A type of focal automatism seizure characterized by manual automatisms at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032900		
HP:0005314	biolink:PhenotypicFeature	Anomalous branches of internal carotid artery		UMLS:C1847886	hp.json		http://purl.obolibrary.org/obo/HP_0005314		
HP:0005315	biolink:PhenotypicFeature	obsolete Peripheral artery occlusive disease			hp.json		http://purl.obolibrary.org/obo/HP_0005315		
HP:0007976	biolink:PhenotypicFeature	Cerulean cataract	Cerulean cataracts are a kind of congenital cataract having peripheral bluish and white opacifications in concentric layers with occasional central lesions arranged radially. Although the opacities may be observed during fetal development and childhood, usually visual acuity is only mildly reduced until adulthood, when lens extraction is generally necessary.	SNOMEDCT_US:204138006|MSH:C537955|UMLS:C0344523	hp.json	Cataracts, congenital, cerulean	http://purl.obolibrary.org/obo/HP_0007976		
HP:0007971	biolink:PhenotypicFeature	Lamellar cataract	A congenital cataract in which opacity is limited to layers of the lens external to the nucleus (i.e., the perinuclear region), i.e., between the nuclear and cortical layers of the lens.	UMLS:C0266537|SNOMEDCT_US:21590003|SNOMEDCT_US:204128001	hp.json		http://purl.obolibrary.org/obo/HP_0007971		
OBO:MAXO_0000556	biolink:NamedThing	interleukin-2 biomarker measurement	Detection of interleukin-2, a mediator of inflammatory response.		hp.json	IL-2 testing|IL-2 level assessment	http://purl.obolibrary.org/obo/MAXO_0000556		
HP:0032909	biolink:PhenotypicFeature	Focal impaired awareness automatism seizure	A focal seizure with automatism in which awareness is partially or fully impaired at some point during the seizure.		hp.json		http://purl.obolibrary.org/obo/HP_0032909		
OBO:MAXO_0000557	biolink:NamedThing	interleukin-8 biomarker measurement	Detection of interleukin-8 levels, a mediator of inflammatory response.		hp.json	IL-8 level assessment|IL-8 testing	http://purl.obolibrary.org/obo/MAXO_0000557		
HP:0007970	biolink:PhenotypicFeature	Congenital ptosis		SNOMEDCT_US:61989004|SNOMEDCT_US:268163008|UMLS:C0266573	hp.json	Congenital drooping upper eyelid	http://purl.obolibrary.org/obo/HP_0007970		
OBO:MAXO_0000554	biolink:NamedThing	interleukin-1 beta biomarker measurement	Detection of interleukin-1 beta levels, an IL-1 cytokine family protein, secreted by macrophages and a mediator of inflammatory response.		hp.json	IL-1 beta assessment	http://purl.obolibrary.org/obo/MAXO_0000554		
HP:0007973	biolink:PhenotypicFeature	Retinal dysplasia	The presence of developmental dysplasia of the retina.	SNOMEDCT_US:95494009|UMLS:C0035313|MSH:D015792	hp.json	Retinal dysgenesis	http://purl.obolibrary.org/obo/HP_0007973		hposlim_core
HP:0005310	biolink:PhenotypicFeature	Large vessel vasculitis	A type of vasculitis (inflammation of blood vessel walls) affecting large arteries such as the aorta and branches of the aorta.	UMLS:C4025218	hp.json		http://purl.obolibrary.org/obo/HP_0005310		
HP:0005311	biolink:PhenotypicFeature	Agenesis of pulmonary vessels	A developmental defect characterized by the lack of formation of the pulmonary blood vessels.	UMLS:C1970630	hp.json	Absent lung vessels	http://purl.obolibrary.org/obo/HP_0005311		
OBO:MAXO_0000555	biolink:NamedThing	interleukin-1 alpha biomarker measurement	Detection of interleukin-1 alpha, a mediator of the inflammatory response.		hp.json	IL-1 alpha testing|IL-1 alpha assessment	http://purl.obolibrary.org/obo/MAXO_0000555		
HP:0032906	biolink:PhenotypicFeature	Focal head nodding automatism seizure	A type of focal automatism seizure characterized by involuntary head nodding at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032906		
HP:0032905	biolink:PhenotypicFeature	Focal sexual automatism seizure	A type of focal automatism seizure characterized by involuntary sexual behavior at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032905		
OBO:MAXO_0000558	biolink:NamedThing	interleukin-12 biomarker measurement	Detection of interleukin-12 levels, an inflammatory cytokine.		hp.json	IL-12 assessment|IL-12 level testing	http://purl.obolibrary.org/obo/MAXO_0000558		
HP:0032908	biolink:PhenotypicFeature	Focal aware undressing automatism seizure	A type of focal automatism seizure characterized by involuntary undressing at onset and during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0032908		
OBO:MAXO_0000559	biolink:NamedThing	tumor necrosis factor-alpha biomarker measurement	Detection of TNF-alpha levels, a cytokine involved in systemic inflammation.		hp.json	TNF-alpha assessment|TNF-alpha level testing	http://purl.obolibrary.org/obo/MAXO_0000559		
HP:0032907	biolink:PhenotypicFeature	Focal undressing automatism seizure	A type of focal automatism seizure characterized by involuntary undressing at onset.		hp.json		http://purl.obolibrary.org/obo/HP_0032907		
CHEBI:48854	biolink:ChemicalSubstance	sulfurous acid		Gmelin:1458|UM-BBD_compID:c0348|KNApSAcK:C00019662|KEGG:C00094|CAS:7782-99-2|PDBeChem:SO3	hp.json	acide sulfureux|Sulfite|Sulfurous acid|acido sulfuroso|sulphurous acid|dihydrogen trioxosulfate|trioxosulfuric acid|dihydroxidooxidosulfur|H2SO3|S(O)(OH)2|[SO(OH)2]|schweflige Saeure|sulfurous acid	http://purl.obolibrary.org/obo/CHEBI_48854		3_STAR
CHEBI:22221	biolink:ChemicalSubstance	acyl group	An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids.		hp.json	groupe acyle|alkanoyl|alkanoyl group|acyl groups|acyl group	http://purl.obolibrary.org/obo/CHEBI_22221		3_STAR
UBERON:0003449	biolink:AnatomicalEntity	tail intervertebral disc	An intervertebral disk that is part of a tail [Automatically generated definition].	EMAPA:19592|MA:0000698	hp.json	intervertebral disc of tail|tail intervertebral disk|intervertebral disc of post-ventral region|tail spinal disc|intervertebral disk of post-ventral region|intervertebral disk of tail	http://purl.obolibrary.org/obo/UBERON_0003449		
GO:0045598	biolink:BiologicalProcess	regulation of fat cell differentiation	Any process that modulates the frequency, rate or extent of adipocyte differentiation.		hp.json	regulation of adipocyte differentiation|regulation of adipocyte cell differentiation	http://purl.obolibrary.org/obo/GO_0045598		
GO:0045599	biolink:BiologicalProcess	negative regulation of fat cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.		hp.json	negative regulation of adipocyte differentiation|downregulation of fat cell differentiation|down regulation of fat cell differentiation|inhibition of fat cell differentiation|down-regulation of fat cell differentiation|negative regulation of adipocyte cell differentiation	http://purl.obolibrary.org/obo/GO_0045599		
GO:0045596	biolink:BiologicalProcess	negative regulation of cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of cell differentiation.		hp.json	downregulation of cell differentiation|down regulation of cell differentiation|inhibition of cell differentiation|down-regulation of cell differentiation	http://purl.obolibrary.org/obo/GO_0045596		
GO:0045597	biolink:BiologicalProcess	positive regulation of cell differentiation	Any process that activates or increases the frequency, rate or extent of cell differentiation.		hp.json	stimulation of cell differentiation|up regulation of cell differentiation|up-regulation of cell differentiation|activation of cell differentiation|upregulation of cell differentiation	http://purl.obolibrary.org/obo/GO_0045597		
GO:0045595	biolink:BiologicalProcess	regulation of cell differentiation	Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.		hp.json		http://purl.obolibrary.org/obo/GO_0045595		
UBERON:0003450	biolink:AnatomicalEntity	upper jaw incisor	An incisor tooth that is part of a upper jaw [Automatically generated definition].	EHDAA2:0002121|NCIT:C49794|FMA:321754|MA:0001601|UMLS:C1710579|EMAPA:17939	hp.json	upper incisor|incisor tooth of upper jaw|upper jaw incisor tooth|incisor tooth of palatoquadrate arch|palatoquadrate arch incisor tooth|incisor of upper jaw|premaxillary tooth|maxillary incisor tooth|incisor of palatoquadrate arch|palatoquadrate arch incisor	http://purl.obolibrary.org/obo/UBERON_0003450		pheno_slim
UBERON:0003451	biolink:AnatomicalEntity	lower jaw incisor	An incisor tooth that is part of a lower jaw [Automatically generated definition].	UMLS:C1708755|EHDAA2:0001021|NCIT:C49583|MA:0001600|EMAPA:17918|BTO:0001942	hp.json	lower incisor|incisor tooth of ventral mandibular arch|ventral mandibular arch incisor tooth|incisor tooth of lower jaw|lower jaw incisor tooth|incisor of ventral mandibular arch|mandibular incisor|ventral mandibular arch incisor|incisor of lower jaw	http://purl.obolibrary.org/obo/UBERON_0003451		pheno_slim
UBERON:0003458	biolink:AnatomicalEntity	neck bone	A bone that is part of a neck [Automatically generated definition].	MA:0000584|OpenCyc:Mx4rvnpJSJwpEbGdrcN5Y29ycA|EMAPA:37246	hp.json	bone of neck|neck (volume) bone|bone of neck (volume)|bone organ of neck (volume)|neck bone organ|neck (volume) bone organ|bone organ of neck	http://purl.obolibrary.org/obo/UBERON_0003458		
UBERON:0003459	biolink:AnatomicalEntity	chest bone	A bone that is part of a chest [Automatically generated definition].	EMAPA:18025|MA:0000547	hp.json	bone organ of anterolateral part of thorax|anterior thoracic region bone organ|bone of anterolateral part of thorax|anterior thoracic region bone|bone organ of anterior thoracic region|anterolateral part of thorax bone organ|anterolateral part of thorax bone|bone of anterior thoracic region|front of thorax bone organ|bone of chest|chest bone organ|front of thorax bone|bone organ of chest|bone of front of thorax|bone organ of front of thorax	http://purl.obolibrary.org/obo/UBERON_0003459		
UBERON:0003456	biolink:AnatomicalEntity	respiratory system lymphatic vessel	A lymphatic vessel that is part of a respiratory system [Automatically generated definition].	MA:0001824|EMAPA:37580	hp.json	respiratory system lymph vessel|apparatus respiratorius lymphatic vessel|lymph vessel of apparatus respiratorius|apparatus respiratorius lymph vessel|lymphatic vessel of apparatus respiratorius|lymphatic vessel of respiratory system|lymph vessel of respiratory system	http://purl.obolibrary.org/obo/UBERON_0003456		
UBERON:0003457	biolink:AnatomicalEntity	head bone	A bone that is part of a head [Automatically generated definition].	EMAPA:35996|MA:0000576|SCTID:118646007	hp.json	craniofacial bone|craniofacial bone|head bone organ|bone organ of adult head|bone of adult head|adult head bone organ|adult head bone|bone organ of head|bone of head	http://purl.obolibrary.org/obo/UBERON_0003457		pheno_slim
UBERON:0003438	biolink:AnatomicalEntity	iris nerve	Any nerve that innervates the iris.	EMAPA:35449|MA:0001291	hp.json	nerve of iris|ciliary nerve	http://purl.obolibrary.org/obo/UBERON_0003438		
CHEBI:24898	biolink:ChemicalSubstance	isoleucine	A 2-amino-3-methylpentanoic acid having either (2R,3R)- or (2S,3S)-configuration.	CAS:443-79-8|CAS:443-79-8|Reaxys:1721790|Beilstein:1721790|PMID:17190852	hp.json	isoleucine|rel-(2R,3R)-2-amino-3-methylpentanoic acid|Hile	http://purl.obolibrary.org/obo/CHEBI_24898		3_STAR
PR:P08508	biolink:Protein	low affinity immunoglobulin gamma Fc region receptor III (mouse)	A low affinity immunoglobulin gamma Fc region receptor III that is encoded in the genome of mouse.	UniProtKB:P08508	hp.json	Fcgr3|CD16 (mouse)|FcRIII (mouse)|mFcgr3|IgG Fc receptor III (mouse)|Fc-gamma RIII (mouse)	http://purl.obolibrary.org/obo/PR_P08508		
UBERON:0003439	biolink:AnatomicalEntity	nerve of trunk region	A nerve that is part of the trunk region of the body (not to be confused with a nerve trunk).	MA:0000515|EMAPA:37264	hp.json	nerve of torso|torso nerve|trunk nerve|nerve of trunk	http://purl.obolibrary.org/obo/UBERON_0003439		non_informative|grouping_class
GO:0008610	biolink:BiologicalProcess	lipid biosynthetic process	The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.		hp.json	lipid synthesis|lipid formation|lipid biosynthesis|lipid anabolism|lipogenesis	http://purl.obolibrary.org/obo/GO_0008610		
UBERON:0015420	biolink:AnatomicalEntity	ureteral valve	A valve that is part of a ureter.	EMAPA:37781|MA:0002658	hp.json	valve or ureter|ureteral valve	http://purl.obolibrary.org/obo/UBERON_0015420		
UBERON:0003440	biolink:AnatomicalEntity	limb nerve	A nerve that is part of a limb [Automatically generated definition].	EMAPA:37291|MA:0000693	hp.json	nerve of limb	http://purl.obolibrary.org/obo/UBERON_0003440		
NCBITaxon:9443	biolink:OrganismalEntity	Primates			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_9443		
UBERON:0015418	biolink:AnatomicalEntity	urethra mesenchymal layer	A mesenchyme that is part of a urethra.	EMAPA:37786|MA:0002648	hp.json		http://purl.obolibrary.org/obo/UBERON_0015418		
UBERON:0003447	biolink:AnatomicalEntity	digit nerve of manus	A nerve that is part of a finger [Automatically generated definition].	MA:0000625|EMAPA:37341	hp.json	digitus manus nerve|nerve of finger|nerve of digit of terminal segment of free upper limb|nerve of terminal segment of free upper limb digit|hand digit nerve|finger nerve|terminal segment of free upper limb digit nerve|nerve of digit of hand|nerve of digitus manus|digit of terminal segment of free upper limb nerve|nerve of hand digit|digit of hand nerve	http://purl.obolibrary.org/obo/UBERON_0003447		
UBERON:0003448	biolink:AnatomicalEntity	manus nerve	A nerve that is part of a manus [Automatically generated definition].	MA:0000629|EMAPA:37340	hp.json	nerve of hand|nerve of manus|hand nerve	http://purl.obolibrary.org/obo/UBERON_0003448		
UBERON:0003445	biolink:AnatomicalEntity	pes nerve	A nerve that is part of a foot [Automatically generated definition].	EMAPA:37347|MA:0000653	hp.json	foot nerve|nerve of foot	http://purl.obolibrary.org/obo/UBERON_0003445		
UBERON:0003446	biolink:AnatomicalEntity	ankle nerve	A nerve that is part of an ankle [Automatically generated definition].	MA:0000640|EMAPA:37346	hp.json	tarsal region nerve|nerve of ankle|neural network of ankle	http://purl.obolibrary.org/obo/UBERON_0003446		
UBERON:0003443	biolink:AnatomicalEntity	thoracic cavity nerve	A nerve that is located in a thoracic cavity [Automatically generated definition].	EMAPA:37267|MA:0000556	hp.json	nerve of chest cavity|cavity of thorax nerve|nerve of cavity of thorax|nerve of thoracic cavity|nerve of pectoral cavity|nerve of cavity of chest|chest cavity nerve|cavity of chest nerve|pectoral cavity nerve	http://purl.obolibrary.org/obo/UBERON_0003443		
UBERON:0003444	biolink:AnatomicalEntity	pelvis nerve	A nerve that is part of a pelvis [Automatically generated definition].	EMAPA:37269|MA:0000542	hp.json	nerve of pelvis	http://purl.obolibrary.org/obo/UBERON_0003444		
MPATH:515	biolink:NamedThing	non-Lymphoid neoplasias	Hematological neoplasias of non-lymphoid origin.	URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2	hp.json		http://purl.obolibrary.org/obo/MPATH_515		
UBERON:0003441	biolink:AnatomicalEntity	forelimb nerve	A nerve that is part of a forelimb [Automatically generated definition].	EMAPA:37334|MA:0000616	hp.json	nerve of superior member|nerve of upper extremity|nerve of fore limb|nerve of forelimb|fore limb nerve|wing nerve	http://purl.obolibrary.org/obo/UBERON_0003441		
UBERON:0003442	biolink:AnatomicalEntity	hindlimb nerve	A nerve that is part of a hindlimb [Automatically generated definition].	EMAPA:37342|MA:0000664	hp.json	nerve of inferior member|nerve of hind limb|hind limb nerve|nerve of lower extremity|nerve of hindlimb	http://purl.obolibrary.org/obo/UBERON_0003442		
CHEBI:24863	biolink:ChemicalSubstance	iodophenol			hp.json	iodophenol	http://purl.obolibrary.org/obo/CHEBI_24863		3_STAR
CHEBI:24862	biolink:ChemicalSubstance	iodoamino acid	An amino acid containing at least one iodo substituent.		hp.json		http://purl.obolibrary.org/obo/CHEBI_24862		3_STAR
CL:0017502	biolink:Cell	acidophilic cytoplasm	Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain.		hp.json	eosinophilic	http://purl.obolibrary.org/obo/CL_0017502		
CHEBI:24860	biolink:ChemicalSubstance	iodine molecular entity			hp.json	iodine molecular entity|iodine molecular entities|iodine compounds	http://purl.obolibrary.org/obo/CHEBI_24860		3_STAR
CL:0017500	biolink:Cell	neutrophillic cytoplasm	Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain.		hp.json		http://purl.obolibrary.org/obo/CL_0017500		
UBERON:0003429	biolink:AnatomicalEntity	abdomen nerve	A nerve that is part of an abdomen [Automatically generated definition].	MA:0000521	hp.json	nerve of abdomen	http://purl.obolibrary.org/obo/UBERON_0003429		
CL:0017505	biolink:Cell	increased nucleus size	A nucleus size quality which is relatively high compared to the amount of cytoplasm present in the same cell.		hp.json		http://purl.obolibrary.org/obo/CL_0017505		
CHEBI:24867	biolink:ChemicalSubstance	monoatomic ion			hp.json	monoatomic ions	http://purl.obolibrary.org/obo/CHEBI_24867		3_STAR
CHEBI:24866	biolink:ChemicalSubstance	salt	A salt is an assembly of cations and anions.		hp.json	Salz|sales|ionic compounds|sel|Salze|sels|ionic compound|salt|sal|salts	http://purl.obolibrary.org/obo/CHEBI_24866		3_STAR
OBO:MAXO_0000520	biolink:NamedThing	obstetric ultrasonography	Use of medical ultrasonography in pregnancy where sound waves are used to create a real-time visual image of the developing fetus in the uterus. Imaging can include the mother's ovaries and uterus as well.		hp.json	prenatal ultrasound procedure|obstetric sonography	http://purl.obolibrary.org/obo/MAXO_0000520		
CL:0017503	biolink:Cell	basophilic cytoplasm	Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions.		hp.json		http://purl.obolibrary.org/obo/CL_0017503		
UBERON:0003427	biolink:AnatomicalEntity	abdominal fat pad	The encapsulated adipose tissue in the abdomen.	MA:0000472|EMAPA:36499	hp.json	abdominal fat depot|abdomen fat pad|fat pad of abdomen	http://purl.obolibrary.org/obo/UBERON_0003427		pheno_slim
CHEBI:24864	biolink:ChemicalSubstance	iodothyronine	An  iodoamino acid in which the amino acid specified is  thyronine.		hp.json	iodothyronines	http://purl.obolibrary.org/obo/CHEBI_24864		3_STAR
UBERON:0003428	biolink:AnatomicalEntity	gonadal fat pad	The encapsulated adipose tissue associated with the ovaries or testes.	MA:0002547|EFO:0000811|AAO:0000157|XAO:0003050	hp.json	gonadal fat pad|gonadal fat depot|fat pad of gonads|gonad-associated fat pad|gonad fat pad|fat pad of gonad	http://purl.obolibrary.org/obo/UBERON_0003428		pheno_slim|efo_slim
CL:0017504	biolink:Cell	polychromatophilic cytoplasm	Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions.		hp.json		http://purl.obolibrary.org/obo/CL_0017504		
UBERON:0015410	biolink:AnatomicalEntity	heart plus pericardium		EMAPA:37597|MA:0002449	hp.json	heart/pericardium	http://purl.obolibrary.org/obo/UBERON_0015410		
CHEBI:36841	biolink:ChemicalSubstance	11-hydroxy steroid			hp.json	11-hydroxy steroids	http://purl.obolibrary.org/obo/CHEBI_36841		3_STAR
OBO:MAXO_0000529	biolink:NamedThing	prenatal genetic testing	Testing of fetal DNA during pregnancy to determine if the fetus has chromosomal aberrations, fetal aneuploidy, or other detectable genetic disorders.		hp.json	fetal genetic testing|prenatal genetic screening|foetal genetic screening	http://purl.obolibrary.org/obo/MAXO_0000529		
UBERON:0003436	biolink:AnatomicalEntity	shoulder nerve	A nerve that is part of a shoulder [Automatically generated definition].	EMAPA:37335|MA:0000634	hp.json	nerve of shoulder	http://purl.obolibrary.org/obo/UBERON_0003436		
UBERON:0003437	biolink:AnatomicalEntity	eyelid nerve	A nerve that innervates an eyelid.	MA:0001255|EMAPA:37535	hp.json	blepharon nerve|nerve of eyelid|palpebral nerve|nerve of blepharon	http://purl.obolibrary.org/obo/UBERON_0003437		
UBERON:0003434	biolink:AnatomicalEntity	wrist nerve	A nerve that is part of a wrist [Automatically generated definition].	EMAPA:37339|MA:0000637	hp.json	nerve of wrist|nerve of carpal region|carpal region nerve	http://purl.obolibrary.org/obo/UBERON_0003434		
UBERON:0003435	biolink:AnatomicalEntity	pedal digit nerve	A nerve that is part of a toe [Automatically generated definition].	EMAPA:37348|MA:0000649	hp.json	nerve of foot digit|digitus pedis nerve|digit of foot nerve|nerve of digit of terminal segment of free lower limb|nerve of toe|nerve of terminal segment of free lower limb digit|toe nerve|terminal segment of free lower limb digit nerve|foot digit nerve|hind limb digit nerve|nerve of digit of foot|nerve of digitus pedis|foot digit nerve|digit of terminal segment of free lower limb nerve	http://purl.obolibrary.org/obo/UBERON_0003435		
CHEBI:24868	biolink:ChemicalSubstance	organic salt			hp.json	organic salts|organisches Salz	http://purl.obolibrary.org/obo/CHEBI_24868		3_STAR
MPATH:502	biolink:NamedThing	monocytic leukaemia	Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts.	URL:http://www.bloodjournal.org/cgi/content/full/100/1/238/DC1/2	hp.json		http://purl.obolibrary.org/obo/MPATH_502		
UBERON:0003432	biolink:AnatomicalEntity	chest nerve	A nerve that is part of a chest [Automatically generated definition].	MA:0000551|EMAPA:37266	hp.json	nerve of front of thorax|nerve of anterior thoracic region|front of thorax nerve|anterolateral part of thorax nerve|anterior thoracic region nerve|nerve of anterolateral part of thorax|nerve of chest	http://purl.obolibrary.org/obo/UBERON_0003432		
OBO:MAXO_0000527	biolink:NamedThing	physical examination	A systemic evaluation of the body and its functions using visual inspection, palpation, percussion and auscultation. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.		hp.json		http://purl.obolibrary.org/obo/MAXO_0000527		
OBO:MAXO_0000528	biolink:NamedThing	prenatal examination	A test or diagnostic examination to assess the health status of the mother and well being of the fetus.	NCIT:C92714	hp.json	antenatal examination	http://purl.obolibrary.org/obo/MAXO_0000528		
UBERON:0003433	biolink:AnatomicalEntity	arm nerve	A nerve that is part of an arm [Automatically generated definition].	MA:0000595|EMAPA:37336	hp.json	nerve of arm|nerve of brachial region|brachial region nerve	http://purl.obolibrary.org/obo/UBERON_0003433		
UBERON:0003430	biolink:AnatomicalEntity	neck nerve	A nerve that is part of a neck [Automatically generated definition].	EMAPA:37263|MA:0000588	hp.json	nerve of neck (volume)|neck (volume) nerve|nerve of neck	http://purl.obolibrary.org/obo/UBERON_0003430		
UBERON:0003431	biolink:AnatomicalEntity	leg nerve	A nerve that is part of a leg [Automatically generated definition].	MA:0000673|EMAPA:37343	hp.json	nerve of leg	http://purl.obolibrary.org/obo/UBERON_0003431		
OBO:MAXO_0000526	biolink:NamedThing	clinical examination	A direct assessment of a patient's condition by a clinical health professional that is based on a physical exam, medical history, and the patient's account of symptoms.	NCIT:C25305	hp.json	examination by physician|medical examination	http://purl.obolibrary.org/obo/MAXO_0000526		
CHEBI:24873	biolink:ChemicalSubstance	iron molecular entity			hp.json	iron compounds|iron molecular entity|iron molecular entities	http://purl.obolibrary.org/obo/CHEBI_24873		3_STAR
UBERON:0003418	biolink:AnatomicalEntity	mesenchyme of submandibular gland	Mesenchyme that is part of a developing submandibular gland [Automatically generated definition].	VHOG:0001110|EMAPA:18814	hp.json	submaxillary gland mesenchyme|submandibular gland mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003418		
UBERON:0003419	biolink:AnatomicalEntity	mesenchyme of parotid	Mesenchyme that is part of a developing parotid gland [Automatically generated definition].	VHOG:0001435|EMAPA:18539	hp.json	mesenchyme of parotid gland|parotid mesenchyme|parotid gland mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003419		
UBERON:0003416	biolink:AnatomicalEntity	mesenchyme of tongue	Mesenchyme that is part of a developing tongue [Automatically generated definition].	EHDAA2:0004614|EMAPA:17882	hp.json	tongue mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003416		
CHEBI:24875	biolink:ChemicalSubstance	iron cation			hp.json	iron cations|Fe cation|iron cation	http://purl.obolibrary.org/obo/CHEBI_24875		3_STAR
UBERON:0003417	biolink:AnatomicalEntity	mesenchyme of soft palate	Mesenchyme that is part of a developing soft palate [Automatically generated definition].	EMAPA:18951	hp.json	soft palate mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003417		
CHEBI:24870	biolink:ChemicalSubstance	ion	A molecular entity having a net electric charge.		hp.json	iones|Ionen|ion|Ion|ions|ion	http://purl.obolibrary.org/obo/CHEBI_24870		3_STAR
NCBITaxon:2653789	biolink:OrganismalEntity	Whippomorpha			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_2653789		
CHEBI:36853	biolink:ChemicalSubstance	hydroxy seco-steroid			hp.json	hydroxy seco-steroids	http://purl.obolibrary.org/obo/CHEBI_36853		3_STAR
UBERON:0003425	biolink:AnatomicalEntity	renal lymph node	A lymph node that is located in a kidney [Automatically generated definition].	NCIT:C77646|UMLS:C2699031|MA:0002882|FMA:276799	hp.json	lymph node of kidney|kidney lymph node	http://purl.obolibrary.org/obo/UBERON_0003425		
UBERON:0003426	biolink:AnatomicalEntity	dermis adipose tissue	An adipose tissue that is part of a dermis [Automatically generated definition].	MA:0000798	hp.json	dermis fatty tissue|adipose tissue of dermis|fat tissue of dermis|dermis fat tissue|fatty tissue of dermis	http://purl.obolibrary.org/obo/UBERON_0003426		pheno_slim
UBERON:0003424	biolink:AnatomicalEntity	mesenchyme of hard palate	Mesenchyme that is part of a developing hard palate [Automatically generated definition].	EMAPA:18954	hp.json	hard palate mesenchyme	http://purl.obolibrary.org/obo/UBERON_0003424		
UBERON:0003422	biolink:AnatomicalEntity	mesenchyme of umbilical cord	A gelatinous substance within the umbilical cord, largely made up of mucopolysaccharides (hyaluronic acid and chondroitin sulfate). It also contains some fibroblasts and macrophages. It is derived from Extra Embryonic Mesoderm[WP].	EMAPA:35925|EMAPA:26127	hp.json	umbilical cord mesenchyme|Wharton's jelly	http://purl.obolibrary.org/obo/UBERON_0003422		
UBERON:0003420	biolink:AnatomicalEntity	mesenchyme of sublingual gland	Mesenchyme that is part of a developing sublingual gland [Automatically generated definition].	VHOG:0001106|EMAPA:18811	hp.json	sublingual gland mesenchyme|mesenchyme of Rivinus'gland|Rivinus'gland mesenchyme|ductus sublingualis mesenchyme|mesenchyme of ductus sublingualis	http://purl.obolibrary.org/obo/UBERON_0003420		
UBERON:0015474	biolink:AnatomicalEntity	axilla skin	A zone of skin that is part of a axilla.	NCIT:C116164|FMA:37322|EMAPA:37349|MA:0003087	hp.json	axillary skin|skin of axilla	http://purl.obolibrary.org/obo/UBERON_0015474		
UBERON:0015479	biolink:AnatomicalEntity	scrotum skin	A zone of skin that is part of a scrotum.	FMA:20432|MA:0003093|EMAPA:36411	hp.json	skin of scrotum|scrotal skin	http://purl.obolibrary.org/obo/UBERON_0015479		pheno_slim
UBERON:0015476	biolink:AnatomicalEntity	nose skin	A zone of skin that is part of a external nose.	EMAPA:37684|FMA:24763|MA:0003090	hp.json	skin of external nose|skin of nose|external nasal skin	http://purl.obolibrary.org/obo/UBERON_0015476		
HP:0007906	biolink:PhenotypicFeature	Ocular hypertension	Intraocular pressure that is 2 standard deviations above the population mean.	SNOMEDCT_US:112222000|UMLS:C0234708	hp.json	Raised intraocular pressure|Elevated intraocular pressure|Elevated IOP|Raised IOP|Increased intraocular pressure|High eye pressure|Increased IOP	http://purl.obolibrary.org/obo/HP_0007906		
HP:0007905	biolink:PhenotypicFeature	Abnormal iris vasculature		UMLS:C3275963	hp.json	Abnormality of iris blood vessels	http://purl.obolibrary.org/obo/HP_0007905		
UBERON:0015477	biolink:AnatomicalEntity	axillary fat pad	A fat pad that is part of a axilla.	MA:0003091	hp.json		http://purl.obolibrary.org/obo/UBERON_0015477		
HP:0007902	biolink:PhenotypicFeature	Vitreous hemorrhage	Bleeding within the vitreous compartment of the eye.	UMLS:C0042909|SNOMEDCT_US:31341008|MSH:D014823	hp.json	Vitreous haemorrhage	http://purl.obolibrary.org/obo/HP_0007902		hposlim_core
UBERON:0003494	biolink:AnatomicalEntity	respiratory system venule	A venule that is part of a respiratory system [Automatically generated definition].	EMAPA:37587|MA:0001813	hp.json	venule of respiratory system|apparatus respiratorius venule|venule of apparatus respiratorius	http://purl.obolibrary.org/obo/UBERON_0003494		
UBERON:0003495	biolink:AnatomicalEntity	respiratory system arteriole	An arteriole that is part of a respiratory system [Automatically generated definition].	EMAPA:37568|MA:0001803	hp.json		http://purl.obolibrary.org/obo/UBERON_0003495		
HP:0007901	biolink:PhenotypicFeature	obsolete Retinal malformation			hp.json		http://purl.obolibrary.org/obo/HP_0007901		
HP:0007903	biolink:PhenotypicFeature	Paravenous chorioretinal atrophy	Chorioretinal atrophy along the retinal veins.	UMLS:C4072868	hp.json		http://purl.obolibrary.org/obo/HP_0007903		
HP:0007900	biolink:PhenotypicFeature	Hypoplastic lacrimal duct		UMLS:C1968574	hp.json	Underdeveloped tear duct	http://purl.obolibrary.org/obo/HP_0007900		
UBERON:0003498	biolink:AnatomicalEntity	heart blood vessel	A blood vessel that is part of a heart [Automatically generated definition].	EMAPA:35397|MA:0002483	hp.json	blood vessel of heart|cardiac blood vessel	http://purl.obolibrary.org/obo/UBERON_0003498		pheno_slim
UBERON:0003499	biolink:AnatomicalEntity	brain blood vessel	A blood vessel that is part of a brain [Automatically generated definition].	MA:0002769|EMAPA:35182	hp.json	blood vessel of brain	http://purl.obolibrary.org/obo/UBERON_0003499		pheno_slim
UBERON:0003496	biolink:AnatomicalEntity	head blood vessel	A blood vessel that is part of a head [Automatically generated definition].	EMAPA:36610|MA:0000575|SCTID:127865000	hp.json	blood vessel of adult head|adult head blood vessel|blood vessel of head	http://purl.obolibrary.org/obo/UBERON_0003496		
UBERON:0003497	biolink:AnatomicalEntity	abdomen blood vessel	A blood vessel that is part of an abdomen [Automatically generated definition].	MA:0000518	hp.json	blood vessel of abdomen	http://purl.obolibrary.org/obo/UBERON_0003497		
CHEBI:36838	biolink:ChemicalSubstance	17-hydroxy steroid	A hydroxy steroid carrying a hydroxy group at position 17.		hp.json	17-hydroxy steroids	http://purl.obolibrary.org/obo/CHEBI_36838		3_STAR
CHEBI:36836	biolink:ChemicalSubstance	3beta-hydroxy steroid	A 3-hydroxy steroid in which the 3-hydroxy substituent is in the  beta-position.	PMID:10535978|MetaCyc:3-Beta-Hydroxysterols|PMID:12829805|KEGG:C02945	hp.json	a 3beta-hydroxysteroid|3beta-hydroxy steroids	http://purl.obolibrary.org/obo/CHEBI_36836		3_STAR
HP:0007917	biolink:PhenotypicFeature	Tractional retinal detachment	A type of retinal detachment arising due to a combination of contracting retinal membranes, abnormal vitreoretinal adhesions, and vitreous changes. It is usually seen in the context of diseases that induce a fibrovascular response, e.g. diabetes.	UMLS:C1866178	hp.json		http://purl.obolibrary.org/obo/HP_0007917		
HP:0007916	biolink:PhenotypicFeature	obsolete Small anterior lens surface opacities			hp.json		http://purl.obolibrary.org/obo/HP_0007916		
HP:0007913	biolink:PhenotypicFeature	Reticular retinal dystrophy	A type of of patterned retinal dystrophy that shows a reticular pattern of pigmentation.	UMLS:C4024776	hp.json		http://purl.obolibrary.org/obo/HP_0007913		
CHEBI:36830	biolink:ChemicalSubstance	monoanion			hp.json	monoanions	http://purl.obolibrary.org/obo/CHEBI_36830		3_STAR
UBERON:0003483	biolink:AnatomicalEntity	thymus lymphoid tissue	A portion of lymphoid tissue that is part of a thymus [Automatically generated definition].	UMLS:C1515429|NCIT:C38515|MA:0002673|MESH:D013950|EMAPA:37766	hp.json	lymphoid tissue of thymus gland|lymphoid tissue of thymus|thymus gland lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0003483		
UBERON:0003484	biolink:AnatomicalEntity	eye sebaceous gland	A sebaceous gland that is part of a camera-type eye. Example: a tarsal gland.	MA:0002452|EMAPA:37531	hp.json	sebaceous gland of vertebrate eye|camera-type eye sebaceous gland|sebaceous gland of camera-type eye|vertebrate eye sebaceous gland	http://purl.obolibrary.org/obo/UBERON_0003484		organ_slim
UBERON:0003481	biolink:AnatomicalEntity	tail vein	A vein that is part of a tail [Automatically generated definition].	AAO:0011105|MA:0002233|XAO:0000393|EMAPA:37761	hp.json	post-vent region vein|vein of post-vent region|vein of tail|caudal vein	http://purl.obolibrary.org/obo/UBERON_0003481		
HP:0007915	biolink:PhenotypicFeature	Polymorphous posterior corneal dystrophy	This corneal dystrophy affects the posterior limiting membrane of the cornea and is characterized by polymorphous plaques of calcium deposits in the deep stromal layers of the cornea, and occasionally by vesicular lesions of the endothelium and edema of the deep corneal stroma.	UMLS:C0339284|SNOMEDCT_US:29504002|MSH:C562745	hp.json		http://purl.obolibrary.org/obo/HP_0007915		
UBERON:0003482	biolink:AnatomicalEntity	vein of trabecular bone	A portion of vein that is part of a trabecular bone tissue [Automatically generated definition].	MA:0002254|EMAPA:37203	hp.json	vein of trabecular bone tissue|spongy bone vein|trabecular bone tissue vein|vein of spongy bone|trabecular bone vein	http://purl.obolibrary.org/obo/UBERON_0003482		
CHEBI:36834	biolink:ChemicalSubstance	3-hydroxy steroid	Any hydroxy steroid carrying a hydroxy group at position 3.		hp.json	3-hydroxy steroids	http://purl.obolibrary.org/obo/CHEBI_36834		3_STAR
UBERON:0003480	biolink:AnatomicalEntity	vein of clitoris	A vein that is part of a clitoris [Automatically generated definition].	MA:0002252|EMAPA:37201	hp.json	clitoris vein	http://purl.obolibrary.org/obo/UBERON_0003480		
HP:0007911	biolink:PhenotypicFeature	Congenital bilateral ptosis		UMLS:C1836264	hp.json	Congenital drooping of both upper eyelids|Ptosis, congenital bilateral|Ptosis, bilateral congenital	http://purl.obolibrary.org/obo/HP_0007911		
HP:0007910	biolink:PhenotypicFeature	obsolete Nonprogressive congenital retinal dystrophy			hp.json		http://purl.obolibrary.org/obo/HP_0007910		
CHEBI:24859	biolink:ChemicalSubstance	iodine atom	Chemical element with atomic number 53.	WebElements:I	hp.json	Jod|Iod|53I|J|I|iode|iodine|iodium|iodine|yodo	http://purl.obolibrary.org/obo/CHEBI_24859		3_STAR
UBERON:0003489	biolink:AnatomicalEntity	respiratory system capillary endothelium	An endothelium of capillary that is part of a respiratory system [Automatically generated definition].	EMAPA:37575|MA:0001808	hp.json	respiratory system endothelium of capillary vessel|apparatus respiratorius endothelium of blood capillary|blood capillary endothelium of apparatus respiratorius|capillary vessel endothelium of respiratory system|endothelium of capillary of respiratory system|respiratory system blood capillary endothelium|endothelium of blood capillary of apparatus respiratorius|endothelium of capillary vessel of apparatus respiratorius|respiratory system capillary vessel endothelium|capillary endothelium of respiratory system|respiratory system endothelium of capillary|capillary endothelium of apparatus respiratorius|apparatus respiratorius capillary endothelium|endothelium of blood capillary of respiratory system|endothelium of capillary vessel of respiratory system|endothelium of capillary of apparatus respiratorius|apparatus respiratorius capillary vessel endothelium|capillary vessel endothelium of apparatus respiratorius|blood capillary endothelium of respiratory system|apparatus respiratorius endothelium of capillary|respiratory system endothelium of blood capillary|apparatus respiratorius endothelium of capillary vessel|apparatus respiratorius blood capillary endothelium	http://purl.obolibrary.org/obo/UBERON_0003489		
UBERON:0003487	biolink:AnatomicalEntity	skin sebaceous gland	A holocrine gland of the dermis that secretes sebum into hair follicles.	MA:0000149	hp.json	cutaneous sebaceous gland|sebaceous gland of skin	http://purl.obolibrary.org/obo/UBERON_0003487		pheno_slim
UBERON:0003488	biolink:AnatomicalEntity	abdominal mammary gland	A lactiferous gland that is part of the abdominal region [Automatically generated definition].	MA:0000787|EMAPA:36507	hp.json	lobe of breast of abdomen|lactiferous gland of abdomen|abdomen lobe of breast|abdomen lobe of mammary gland|abdomen mammary gland|mammary gland of abdomen|lobe of mammary gland of abdomen|abdomen lactiferous gland	http://purl.obolibrary.org/obo/UBERON_0003488		
UBERON:0003485	biolink:AnatomicalEntity	vagina sebaceous gland	A sebaceous gland that is part of a vagina [Automatically generated definition].	EMAPA:37793|MA:0001732	hp.json	sebaceous gland of vagina	http://purl.obolibrary.org/obo/UBERON_0003485		organ_slim
UBERON:0015458	biolink:AnatomicalEntity	mediastinal fat pad	A fat pad that is part of a mediastinum.	MA:0003063	hp.json		http://purl.obolibrary.org/obo/UBERON_0015458		
UBERON:0015454	biolink:AnatomicalEntity	pancreatic fat pad	A fat pad that is part of a pancreas.	MA:0003029	hp.json		http://purl.obolibrary.org/obo/UBERON_0015454		human_reference_atlas
UBERON:0015453	biolink:AnatomicalEntity	subcutaneous lymph node	A lymph node that is part of a hypodermis.	MA:0003028	hp.json		http://purl.obolibrary.org/obo/UBERON_0015453		
UBERON:0003472	biolink:AnatomicalEntity	cerebellar artery	An artery that supplies blood to the cerebellum.	NCIT:C52845|MA:0001933|EMAPA:37074|EHDAA2:0000228|EHDAA:5290|UMLS:C0226246	hp.json		http://purl.obolibrary.org/obo/UBERON_0003472		
UBERON:0003473	biolink:AnatomicalEntity	thoracic cavity artery	An artery that is part of a thoracic cavity[cjm].	MA:0001902|EMAPA:37241|MESH:D013895	hp.json	thoracic artery	http://purl.obolibrary.org/obo/UBERON_0003473		
UBERON:0003470	biolink:AnatomicalEntity	artery of upper lip	The superior labial artery (superior labial branch of facial artery) is larger and more tortuous than the inferior labial artery. It follows a similar course along the edge of the upper lip, lying between the mucous membrane and the Orbicularis oris, and anastomoses with the artery of the opposite side. It supplies the upper lip, and gives off in its course two or three vessels which ascend to the nose; a septal branch ramifies on the nasal septum as far as the point of the nose, and an alar branch supplies the ala of the nose.	EMAPA:37430|FMA:49570|MA:0001917	hp.json	superior labial branch of facial artery|superior labial artery|arteria labialis superior|ramus labialis superior arteriae facialis	http://purl.obolibrary.org/obo/UBERON_0003470		human_reference_atlas
UBERON:0003471	biolink:AnatomicalEntity	artery of lower lip	The inferior labial artery (inferior labial branch of facial artery) arises near the angle of the mouth; it passes upward and forward beneath the Triangularis and, penetrating the Orbicularis oris, runs in a tortuous course along the edge of the lower lip between this muscle and the mucous membrane. It supplies the labial glands, the mucous membrane, and the muscles of the lower lip; and anastomoses with the artery of the opposite side, and with the mental branch of the inferior alveolar artery.	Wikipedia:Inferior_labial_artery|FMA:49567|EMAPA:37429|MA:0001916|SCTID:145036002	hp.json	arteria labialis inferior|ramus labialis inferior arteriae facialis|inferior labial artery|ramus labialis inferior (arteria facialis)|inferior labial branch of facial artery|arteria labialis inferior|ramus labialis inferior arteriae facialis	http://purl.obolibrary.org/obo/UBERON_0003471		human_reference_atlas
UBERON:0003478	biolink:AnatomicalEntity	vein of lower lip	The inferior labial vein is the vein receiving blood from the lower lip.	EMAPA:37202|FMA:52541|SCTID:422955002|Wikipedia:Inferior_labial_vein|MA:0002253	hp.json	inferior labial vein|vena labialis inferior|lower lip vein|venae labiales inferiores|venae labiales inferiores	http://purl.obolibrary.org/obo/UBERON_0003478		human_reference_atlas
UBERON:0003479	biolink:AnatomicalEntity	thoracic cavity vein	A vein that is part of a thoracic cavity [Automatically generated definition].	MA:0001903|EMAPA:37242	hp.json	cavity of thorax vein|vein of thoracic cavity|vein of pectoral cavity|vein of cavity of chest|vein of chest cavity|cavity of chest vein|pectoral cavity vein|chest cavity vein|vein of cavity of thorax	http://purl.obolibrary.org/obo/UBERON_0003479		
UBERON:0003476	biolink:AnatomicalEntity	respiratory system venous blood vessel	A vein that is part of a respiratory system [Automatically generated definition].	EMAPA:37584|MA:0001810|MA:0001809	hp.json	vein of respiratory system|respiratory system vein|vein of apparatus respiratorius|apparatus respiratorius vein	http://purl.obolibrary.org/obo/UBERON_0003476		
UBERON:0003477	biolink:AnatomicalEntity	vein of upper lip	The inferior labial vein is the vein receiving blood from the upper lip.	FMA:52538|MA:0002255|EMAPA:37204	hp.json	vena labialis superior|superior labial vein|upper lip vein	http://purl.obolibrary.org/obo/UBERON_0003477		human_reference_atlas
UBERON:0003474	biolink:AnatomicalEntity	meningeal artery	One of the arteries supplying a meninix[Automatically generated definition].	Wikipedia:Meningeal_arteries|MESH:D008576|GAID:499|MA:0002001|EMAPA:37104	hp.json		http://purl.obolibrary.org/obo/UBERON_0003474		
UBERON:0003475	biolink:AnatomicalEntity	ureteric vein	A vein that is part of a ureter [Automatically generated definition].	MA:0002250|EMAPA:37679	hp.json	vein of ureter|ureter vein	http://purl.obolibrary.org/obo/UBERON_0003475		
CHEBI:24828	biolink:ChemicalSubstance	indoles	Any compound containing an indole skeleton.		hp.json		http://purl.obolibrary.org/obo/CHEBI_24828		3_STAR
CHEBI:24834	biolink:ChemicalSubstance	inorganic anion			hp.json	inorganic anions	http://purl.obolibrary.org/obo/CHEBI_24834		3_STAR
CHEBI:24833	biolink:ChemicalSubstance	oxoacid	A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).		hp.json	oxacids|oxy-acids|oxo acid|oxiacids|oxyacids|oxoacid|oxoacids	http://purl.obolibrary.org/obo/CHEBI_24833		3_STAR
CHEBI:36818	biolink:ChemicalSubstance	seco-cholestane			hp.json	seco-cholestanes	http://purl.obolibrary.org/obo/CHEBI_36818		3_STAR
UBERON:0003461	biolink:AnatomicalEntity	shoulder bone	A bone that is connected via a shoulder joint (i.e. glenohumeral or acromioclavicular joints). The shoulder bones are the clavicle, scapula and humerus - but note that these are only considered to be shoulder bones when a true shoulder is present, as in most tetrapods.	MA:0000631	hp.json	bone of shoulder|shoulder-articulating bone	http://purl.obolibrary.org/obo/UBERON_0003461		pheno_slim
UBERON:0003462	biolink:AnatomicalEntity	facial bone	A bone that is part of a facial skeleton [Automatically generated definition].	NCIT:C63706|MA:0001482|UMLS:C0015455|MESH:D005147|EMAPA:19019|SCTID:181799005|MA:0003159|EMAPA:35924	hp.json	bone of facial skeleton|facial skeleton bone|bone of viscerocranium|viscerocranium bone|facial bone	http://purl.obolibrary.org/obo/UBERON_0003462		pheno_slim
UBERON:0003460	biolink:AnatomicalEntity	arm bone	A bone that is part of the region of the forelimb that includes the zeugopod and stylopod. Examples: patella, femur, tibia.	MESH:D050280|OpenCyc:Mx4rwKTXoJwpEbGdrcN5Y29ycA|EMAPA:37303|MA:0000592	hp.json	bone of arm|bone organ of arm|arm bone organ|bone of upper extremity	http://purl.obolibrary.org/obo/UBERON_0003460		
UBERON:0003469	biolink:AnatomicalEntity	respiratory system artery	An artery that is part of a respiratory system [Automatically generated definition].	MA:0001804|EMAPA:37569	hp.json		http://purl.obolibrary.org/obo/UBERON_0003469		
CHEBI:24836	biolink:ChemicalSubstance	inorganic oxide			hp.json	inorganic oxides	http://purl.obolibrary.org/obo/CHEBI_24836		3_STAR
CHEBI:24835	biolink:ChemicalSubstance	inorganic molecular entity	A molecular entity that contains no carbon.		hp.json	inorganic compounds|inorganics|inorganic entity|inorganic molecular entities|anorganische Verbindungen	http://purl.obolibrary.org/obo/CHEBI_24835		3_STAR
UBERON:0003468	biolink:AnatomicalEntity	ureteric segment of renal artery	The ureteral branches of renal artery are small branches which supply the ureter.	EMAPA:37676|MA:0002074|FMA:70491	hp.json	ureteric artery	http://purl.obolibrary.org/obo/UBERON_0003468		human_reference_atlas
UBERON:0003466	biolink:AnatomicalEntity	forelimb zeugopod bone	A bone that is part of a lower arm [Automatically generated definition].	EMAPA:35347|MA:0000598	hp.json	zeugopod bone, forelimb|wing zeugopod bone|arm zeugopod bone organ|arm zeugopod bone|antebrachial region bone organ|zeugopod bone, upper|antebrachial region bone|lower arm bone	http://purl.obolibrary.org/obo/UBERON_0003466		pheno_slim
UBERON:0003463	biolink:AnatomicalEntity	trunk bone	A bone that is part of a trunk [Automatically generated definition].	MA:0000512|EMAPA:36583|SCTID:427358002	hp.json	bone of trunk|bone organ of trunk|bone of torso|bone organ of torso|torso bone organ|torso bone|trunk bone organ	http://purl.obolibrary.org/obo/UBERON_0003463		
UBERON:0003464	biolink:AnatomicalEntity	hindlimb bone	A bone that is part of a hindlimb region. Examples: any pes phalanx, femur. Counter-examples: ischium, pubis (they are part of the pelvic girdle).	EFO:0003842|GAID:198|NCIT:C12982|UMLS:C0448188	hp.json	bone organ of lower extremity|bone organ of hindlimb|bone of hindlimb|bone of inferior member|bone of hind limb|bone organ of hind limb|hindlimb bone organ|hind limb bone organ|bone of lower extremity|hind limb bone	http://purl.obolibrary.org/obo/UBERON_0003464		efo_slim
UBERON:0022248	biolink:AnatomicalEntity	cerebral nerve fasciculus		FMA:260712	hp.json	telencephalic nerve fascicle|cerebral fasciculus|nerve fascicle of telencephalon|telencephalic fascicle|cerebral fascicle	http://purl.obolibrary.org/obo/UBERON_0022248		
HP:0009450	biolink:PhenotypicFeature	Broad proximal phalanx of the 3rd finger	Increased width of the proximal phalanx of the 3rd finger.	UMLS:C4024355	hp.json	Broad innermost bone of middle finger	http://purl.obolibrary.org/obo/HP_0009450		
CHEBI:25213	biolink:ChemicalSubstance	metal cation			hp.json	a metal cation|metal cations	http://purl.obolibrary.org/obo/CHEBI_25213		3_STAR
CHEBI:25212	biolink:ChemicalSubstance	metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.		hp.json	secondary metabolites|primary metabolites|metabolites|metabolite	http://purl.obolibrary.org/obo/CHEBI_25212		3_STAR
UBERON:0010260	biolink:AnatomicalEntity	umbilical blood vessel	One of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta.	EMAPA:36493	hp.json	allantoic vessel|umbilical cord blood vessels|umbilical vessel|umbilical cord blood vessel|umbilical vasculature	http://purl.obolibrary.org/obo/UBERON_0010260		pheno_slim
CHEBI:25216	biolink:ChemicalSubstance	metalloporphyrin			hp.json	metalloporphyrins|metaloporphyrins	http://purl.obolibrary.org/obo/CHEBI_25216		3_STAR
HP:0010445	biolink:PhenotypicFeature	Primum atrial septal defect	An ostium primum atrial septal defect is located in the most anterior and inferior aspect of the atrial septum. The ostium primum refers to an anterior and inferior opening (ostium) within the septum primum, which divides the rudimentary atrium during fetal development. The ostium primum is normally sealed by fusion of the superior and inferior endocardial cushions around 5 weeks' gestation. Ostium primum defects result from a failure of the fusion of the embryologic endocardial cushion and septum primum.	MSH:C548006|MSH:C536112|Fyler:1110|UMLS:C0741296|UMLS:C0344735|SNOMEDCT_US:253373002	hp.json	Primum atrioventricular canal defect|Ostium primum atrial septal defect|Atrial septal defect, primum type|Septum primum defect	http://purl.obolibrary.org/obo/HP_0010445		
HP:0010444	biolink:PhenotypicFeature	Pulmonary insufficiency	The retrograde (backwards) flow of blood through the pulmonary valve into the right ventricle during diastole.	UMLS:C0034088|MSH:D011665|SNOMEDCT_US:91434003	hp.json	Pulmonary valve regurgitation|Puolmonary valve insufficiency|Pulmonic regurgitation|Pulmonary incompetence	http://purl.obolibrary.org/obo/HP_0010444		
HP:0010443	biolink:PhenotypicFeature	Bifid femur	A bifid or bifurcated appearance of the femur as seen on x-rays, possible appearing as a more or less severe bowing of the upper leg. Might be associated with hip dysplasia on the affected side.	UMLS:C4023824	hp.json	Split thighbone|Notched thighbone	http://purl.obolibrary.org/obo/HP_0010443		hposlim_core
CHEBI:76807	biolink:ChemicalSubstance	EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor	An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*).		hp.json	non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor|EC 3.5.1.* inhibitors|EC 3.5.1.* inhibitor|non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitors|EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitors	http://purl.obolibrary.org/obo/CHEBI_76807		3_STAR
HP:0010442	biolink:PhenotypicFeature	Polydactyly	A congenital anomaly characterized by the presence of supernumerary fingers or toes.	Fyler:4103|UMLS:C0152427|MSH:D017689|SNOMEDCT_US:367506006	hp.json	More than five fingers or toes on hands or feet	http://purl.obolibrary.org/obo/HP_0010442		
UBERON:0010262	biolink:AnatomicalEntity	operculum of brain	The most posterior portion of the inferior frontal gyrus of the frontal lobe in the brain. In an axial plane, the Sylvian fissure extends from the operculum posteriorly to divide the frontal from the temporal lobe. Broca's area is a notable part of the operculum, which plays a key role in conversation or speech production, reading and writing. Its vascular supply comes from the M3 branches of the middle cerebral artery[WP].		hp.json	operculum	http://purl.obolibrary.org/obo/UBERON_0010262		pheno_slim
HP:0010441	biolink:PhenotypicFeature	Ectopic accessory finger-like appendage	In contrast to forms of polydactyly where the supernumerary digit (this can either be a rudimentary or a completely 'normal' digit) is either located postaxial (on the ulnar side of the hand, next to the little finger), preaxial (on the radial side of the hand, next to the thumb) or mesoaxial (somewhere central, between thumb and little finger), a supernumerary digit may also be placed ectopically, meaning anywhere else except post-,meso- or preaxial. In the literature this is sometimes referred to as Disorganisation-like Syndrome (OMIM223200).	UMLS:C4023825	hp.json		http://purl.obolibrary.org/obo/HP_0010441		
HP:0010440	biolink:PhenotypicFeature	Ectopic accesory toe-like appendage	In contrast to forms of polydactyly where the supernumerary digit (this can either be a rudimentary or a completely 'normal' digit) is either located postaxial (on the fibular side of the foot, next top the little toe), preaxial (on the tibial side of the foot, next to the big toe) or mesoaxial (somewhere central, between big and little toe), a supernumerary digit may also be placed ectopically, meaning anywhere else except post-,meso- or preaxial. In the literature this is sometimes referred to as Disorganisation-like Syndrome (OMIM223200).	UMLS:C4023826	hp.json		http://purl.obolibrary.org/obo/HP_0010440		
CHEBI:15889	biolink:ChemicalSubstance	sterol	Any 3-hydroxy steroid whose skeleton is closely related to cholestan-3-ol (additional carbon atoms may be present in the side chain).	Wikipedia:Sterol|KEGG:C00370|MetaCyc:Sterols|LIPID_MAPS_class:LMST01	hp.json	3-hydroxysteroids|a sterol|sterols|Sterol	http://purl.obolibrary.org/obo/CHEBI_15889		3_STAR
UBERON:0010258	biolink:AnatomicalEntity	mesenchyme from rhombencephalic neural crest	Mesenchyme that develops_from a rhombencephalon neural crest.	EHDAA2:0004423	hp.json		http://purl.obolibrary.org/obo/UBERON_0010258		
UBERON:0010259	biolink:AnatomicalEntity	1st arch mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a 1st arch mesenchyme.	EMAPA:16129	hp.json	mesenchyme derived from neural crest of mesenchyme of 1st arch|branchial arch 1 mesenchyme from neural crest|pharyngeal arch 1 mesenchyme from neural crest|neural crest derived arch 1 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010259		
HP:0009449	biolink:PhenotypicFeature	obsolete Hypoplastic/small phalanges of the 3rd finger			hp.json		http://purl.obolibrary.org/obo/HP_0009449		
HP:0010448	biolink:PhenotypicFeature	Colonic atresia	A developmental defect resulting in complete obliteration of the lumen of the colon. That is, there is an abnormal closure, or atresia of the tubular structure of the colon.	UMLS:C0266190|SNOMEDCT_US:37054000|MSH:C562562	hp.json	Atresia of the large intestine|Large intestinal atresia	http://purl.obolibrary.org/obo/HP_0010448		
HP:0009448	biolink:PhenotypicFeature	obsolete Aplasia of the phalanges of the 3rd finger			hp.json		http://purl.obolibrary.org/obo/HP_0009448		
HP:0010447	biolink:PhenotypicFeature	Anal fistula	An abnormal connection between the epithelialised surface of the anal canal and the perianal skin.	UMLS:C0205929|MEDDRA:10002156|MSH:D012003|SNOMEDCT_US:72779005	hp.json	Fistula in ano	http://purl.obolibrary.org/obo/HP_0010447		hposlim_core
HP:0010446	biolink:PhenotypicFeature	Tricuspid stenosis	A narrowing of the orifice of the tricuspid valve of the heart.	MSH:D014264|SNOMEDCT_US:49915006|UMLS:C0040963|ICD-10:Q22.4|EPCC:06.01.92	hp.json		http://purl.obolibrary.org/obo/HP_0010446		
HP:0009445	biolink:PhenotypicFeature	Symphalangism of the 3rd finger	Fusion of two or more bones of the 3rd finger.	UMLS:C4024358	hp.json	Fused middle finger	http://purl.obolibrary.org/obo/HP_0009445		
HP:0009444	biolink:PhenotypicFeature	Patchy sclerosis of 3rd finger phalanx	Uneven (irregular) increase in bone density of one or more of the phalanges of the third finger.	UMLS:C4021471	hp.json	Uneven increase in bone density in middle finger bone|Patchy sclerosis of middle finger phalanges|Patchy sclerosis of the phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009444		
HP:0009447	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the 3rd finger		UMLS:C4024356	hp.json	Small middle finger phalanges|Absent/underdeveloped middle finger bone|Hypoplastic middle finger phalanges|Absent/small middle finger bone|Short middle finger phalanges	http://purl.obolibrary.org/obo/HP_0009447		
HP:0009446	biolink:PhenotypicFeature	Triangular shaped phalanges of the 3rd finger	Triangular shaped phalanges of the 3rd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024357	hp.json	Triangular shaped bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009446		
HP:0009441	biolink:PhenotypicFeature	Bullet-shaped phalanges of the 3rd finger	A third finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4024360	hp.json	Bullet-shaped bones of middle finger	http://purl.obolibrary.org/obo/HP_0009441		
HP:0009440	biolink:PhenotypicFeature	Broad phalanges of the 3rd finger	Increased width of the phalanges of the 3rd finger.	UMLS:C4021473	hp.json	Wide bones of middle finger|Wide/broad middle finger phalanges	http://purl.obolibrary.org/obo/HP_0009440		
HP:0009443	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the 3rd finger	Dissolution or degeneration of bone tissue of the phalanges of the 3rd finger.	UMLS:C4021472	hp.json	Lytic defects of middle finger phalanges	http://purl.obolibrary.org/obo/HP_0009443		
HP:0009442	biolink:PhenotypicFeature	Curved phalanges of the 3rd finger	Curved appearance of the phalanges of the 3rd finger.	UMLS:C4024359	hp.json	Curved bones of middle finger	http://purl.obolibrary.org/obo/HP_0009442		
HP:0009461	biolink:PhenotypicFeature	Short 3rd finger	Hypoplastic/small 3rd (middle) finger.	UMLS:C4021469	hp.json	Short middle finger|Short 3rd finger|Hypoplastic/small 3rd finger	http://purl.obolibrary.org/obo/HP_0009461		
HP:0009460	biolink:PhenotypicFeature	Aplasia of the 3rd finger	Absent 3rd finger.	UMLS:C4024346	hp.json	Absent middle finger	http://purl.obolibrary.org/obo/HP_0009460		
HP:0010434	biolink:PhenotypicFeature	Aplasia of the middle phalanx of the 2nd toe		UMLS:C4023828	hp.json	Absent middle bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010434		
UBERON:0010252	biolink:AnatomicalEntity	1st arch mandibular mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a 1st arch mandibular mesenchyme.	EHDAA2:0000037	hp.json		http://purl.obolibrary.org/obo/UBERON_0010252		
HP:0010433	biolink:PhenotypicFeature	Short distal phalanx of the 2nd toe	Reduced length of the distal phalanx of the second toe as a result of developmental hypoplasia.	UMLS:C4021267	hp.json	Short outermost bone of the 2nd toe|Hypoplastic/small distal phalanx of the 2nd toe|Short distal phalanx of the second toe	http://purl.obolibrary.org/obo/HP_0010433		
UBERON:0010253	biolink:AnatomicalEntity	1st arch maxillary mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a 1st arch maxillary mesenchyme.	EHDAA2:0000044	hp.json		http://purl.obolibrary.org/obo/UBERON_0010253		
HP:0010432	biolink:PhenotypicFeature	Absent distal phalanx of the 2nd toe	Absence of distal phalanx of the second toe as a result of developmental aplasia.	UMLS:C4021268	hp.json	Absent outermost bone of the 2nd toe|Absent distal phalanx of the second toe|Aplasia of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010432		
HP:0010431	biolink:PhenotypicFeature	Short phalanx of the 2nd toe	Reduced length of one or more phalanx of second toe as a result of developmental hypoplasia.	UMLS:C4021269	hp.json	Short phalanx of the second toe|Short 2nd toe bone|Hypoplastic/small phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010431		
UBERON:0010256	biolink:AnatomicalEntity	4th arch mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a 4th arch mesenchyme.	EMAPA:16772|VHOG:0000580|EHDAA2:0000098	hp.json	4th pharyngeal arch mesenchyme derived from neural crest|mesenchyme derived from neural crest of mesenchyme of 4th arch|branchial arch 4 mesenchyme from neural crest|pharyngeal arch 4 mesenchyme from neural crest|neural crest derived arch 4 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010256		
HP:0010430	biolink:PhenotypicFeature	Aplasia of the phalanges of the 2nd toe		UMLS:C4023829	hp.json	Absent 2nd toe bones	http://purl.obolibrary.org/obo/HP_0010430		
UBERON:0010257	biolink:AnatomicalEntity	6th arch mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a 6th arch mesenchyme.	EHDAA2:0004077	hp.json	neural crest derived arch 6 mesenchyme|pharyngeal arch 6 mesenchyme from neural crest|branchial arch 6 mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010257		
UBERON:0010254	biolink:AnatomicalEntity	2nd arch mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a 2nd arch mesenchyme.	EHDAA2:0000068|EMAPA:16281	hp.json	branchial arch 2 mesenchyme from neural crest|pharyngeal arch 2 mesenchyme from neural crest|neural crest derived arch 2 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010254		
UBERON:0010255	biolink:AnatomicalEntity	3rd arch mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a 3rd arch mesenchyme.	VHOG:0000571|EMAPA:16404|EHDAA2:0000083	hp.json	3rd pharyngeal arch mesenchyme derived from neural crest|mesenchyme derived from neural crest of mesenchyme of 3rd arch|branchial arch 3 mesenchyme from neural crest|pharyngeal arch 3 mesenchyme from neural crest|neural crest derived arch 3 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010255		
HP:0010438	biolink:PhenotypicFeature	Abnormal ventricular septum morphology	A structural abnormality of the interventricular septum.	Fyler:1815|UMLS:C4021264	hp.json	Abnormality of the ventricular septum|Ventricular septum abnormality|Abnormal interventricular septum morphology	http://purl.obolibrary.org/obo/HP_0010438		
HP:0009459	biolink:PhenotypicFeature	Short proximal phalanx of the 3rd finger	Hypoplasia (congenital reduction in size) of the proximal phalanx of the third finger.	UMLS:C4021470	hp.json	Short proximal phalanx of the third finger|Small proximal middle-finger phalanx|Short proximal middle-finger phalanx|Hypoplastic/small proximal phalanx of the 3rd finger|Short innermost bone of middle finger	http://purl.obolibrary.org/obo/HP_0009459		
HP:0010437	biolink:PhenotypicFeature	Short proximal phalanx of the 2nd toe	Reduced length of the proximal phalanx of second toe as a result of developmental hypoplasia.	UMLS:C4021265	hp.json	Short proximal phalanx of the second toe|Short innermost 2nd toe bone|Hypoplastic/small proximal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010437		
HP:0010436	biolink:PhenotypicFeature	Aplasia of the proximal phalanx of the 2nd toe		UMLS:C4023827	hp.json	Absent innermost 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010436		
HP:0010435	biolink:PhenotypicFeature	Short middle phalanx of the 2nd toe	Reduced length of the middle phalanx of second toe as a result of developmental hypoplasia.	UMLS:C4021266	hp.json	Short middle phalanx of the second toe|Hypoplastic/small middle phalanx of the 2nd toe|Short middle 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010435		
HP:0009456	biolink:PhenotypicFeature	Triangular shaped proximal phalanx of the 3rd finger	Triangular shaped proximal phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024349	hp.json	Triangular shaped innermost bone of middle finger	http://purl.obolibrary.org/obo/HP_0009456		
HP:0009455	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanx of the 3rd finger	Fusion of the proximal phalanx of the 3rd finger with another bone.	UMLS:C4024350	hp.json	Fused innermost bone of middle finger	http://purl.obolibrary.org/obo/HP_0009455		
HP:0009458	biolink:PhenotypicFeature	Aplasia of the proximal phalanx of the 3rd finger	Absence of the proximal phalanx of the 3rd finger.	UMLS:C4024347	hp.json	Absent innermost bone of middle finger	http://purl.obolibrary.org/obo/HP_0009458		
HP:0009457	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the proximal phalanx of the 3rd finger		UMLS:C4024348	hp.json	Absent/small innermost bone of middle finger|Absent/underdeveloped innermost bone of middle finger	http://purl.obolibrary.org/obo/HP_0009457		
HP:0009452	biolink:PhenotypicFeature	Curved proximal phalanx of the 3rd finger	Curved appearance of the proximal phalanx of the 3rd finger.	UMLS:C4024353	hp.json	Curved innermost bone of middle finger	http://purl.obolibrary.org/obo/HP_0009452		
HP:0009451	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the 3rd finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 3rd finger is affected.	UMLS:C4024354	hp.json	Bullet-shaped innermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009451		
HP:0009454	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the 3rd finger	Uneven (irregular) increase in bone density of the proximal phalanx of the third finger.	UMLS:C4024351	hp.json	Uneven increase in bone density in the innermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009454		
HP:0009453	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanx of the 3rd finger	Dissolution or degeneration of bone tissue of the proximal phalanx of the 3rd finger.	UMLS:C4024352	hp.json		http://purl.obolibrary.org/obo/HP_0009453		
CHEBI:76823	biolink:ChemicalSubstance	EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor	An EC 6.3.* (C-N bond-forming ligase) inhibitor that interferes with the action of any acid-ammonia (or amine) ligase (EC 6.3.1.*).		hp.json	EC 6.3.1.* inhibitor|acid-ammonia (or amine) ligase inhibitors|acid-ammonia (or amine) ligase inhibitor|EC 6.3.1.* inhibitors|EC 6.3.1.* (acid-ammonia/amine ligase) inhibitors	http://purl.obolibrary.org/obo/CHEBI_76823		3_STAR
CHEBI:76824	biolink:ChemicalSubstance	EC 6.4.1.* (carboxylase) inhibitor	An EC 6.4.* (C-C bond-forming ligase) inhibitor that interferes with the action of a carboxylating enzyme (EC 6.4.1.*).		hp.json	EC 6.4.1.* inhibitor|EC 6.4.1.* (C-C bond forming ligase) inhibitor|EC 6.4.1.* inhibitors|EC 6.4.1.* (C-C bond forming ligase) inhibitors|inhibitors of ligases forming C-C bonds|inhibitor of ligases forming C-C bonds|EC 6.4.1.* (C-C bond-forming ligase) inhibitors|inhibitor of ligases forming C-C bonds (EC 6.4.1.*)|inhibitors of ligases forming C-C bonds (EC 6.4.1.*)|EC 6.4.1.* (carboxylase) inhibitors	http://purl.obolibrary.org/obo/CHEBI_76824		3_STAR
HP:0010423	biolink:PhenotypicFeature	Partial duplication of the proximal phalanx of the 2nd toe	Partial duplication of proximal phalanx of second toe.	UMLS:C4021270	hp.json	Partial duplication of the innermost 2nd toe bone|Partial duplication of the proximal phalanx of the second toe	http://purl.obolibrary.org/obo/HP_0010423		
HP:0010422	biolink:PhenotypicFeature	Complete duplication of the proximal phalanx of the 2nd toe	Complete duplication of proximal phalanx of second toe.	UMLS:C4021271	hp.json	Complete duplication of the proximal phalanx of the second toe|Complete duplication of the innermost 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010422		
HP:0010421	biolink:PhenotypicFeature	Duplication of the distal phalanx of the 2nd toe	Partial or complete duplication of the distal phalanx of second toe.	UMLS:C4021272	hp.json	Duplication of the outermost bone of the 2nd toe|Partial/complete duplication of the distal phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010421		
HP:0010420	biolink:PhenotypicFeature	Triangular shaped distal phalanx of the 2nd toe		UMLS:C4023836	hp.json	Triangular shaped outermost 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010420		
UBERON:0010243	biolink:AnatomicalEntity	merocrine gland	An exocrine gland whose secretions are excreted via exocytosis from secretory cells into an epithelial-walled duct or ducts and thence onto a bodily surface or into the lumen; the gland releases its product and no part of the gland is lost or damaged.	Wikipedia:Merocrine|BTO:0002324|MA:0003041	hp.json		http://purl.obolibrary.org/obo/UBERON_0010243		pheno_slim
HP:0010429	biolink:PhenotypicFeature	Complete duplication of the phalanges of the 2nd toe	Complete duplication of a phalanx of second toe.	UMLS:C4023830	hp.json	Complete duplication of the 2nd toe bones	http://purl.obolibrary.org/obo/HP_0010429		
HP:0010428	biolink:PhenotypicFeature	Partial duplication of phalanx of the 2nd toe	Partial duplication of a phalanx of second toe.	UMLS:C4023831	hp.json	Partial duplication of 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010428		
HP:0010427	biolink:PhenotypicFeature	Partial duplication of the middle phalanx of the 2nd toe	Partial duplication of middle phalanx of second toe.	UMLS:C4023832	hp.json	Partial duplication of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010427		
HP:0009427	biolink:PhenotypicFeature	Triangular shaped distal phalanx of the 3rd finger	Triangular shaped distal phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024370	hp.json	Triangular shaped outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009427		
HP:0009426	biolink:PhenotypicFeature	Distal/middle symphalangism of 3rd finger	Fusion of the terminal/distal and middle phalanges of the 3rd finger.	UMLS:C4021477	hp.json	Symphalangism of the distal and middle phalanges of the 3rd finger|Fused outermost and middle bones of middle finger	http://purl.obolibrary.org/obo/HP_0009426		
HP:0010426	biolink:PhenotypicFeature	Complete duplication of the middle phalanx of the 2nd toe	Complete duplication of middle phalanx of second toe.	UMLS:C4023833	hp.json	Complete duplication of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010426		
HP:0009429	biolink:PhenotypicFeature	Aplasia of the distal phalanx of the 3rd finger	Absence of the distal phalanx of the middle (3rd) finger.	UMLS:C4024368	hp.json	Absent of the outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009429		
HP:0010425	biolink:PhenotypicFeature	Partial duplication of the distal phalanx of the 2nd toe	Partial duplication of the distal phalanx of second toe.	UMLS:C4023834	hp.json	Partial duplication of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010425		
HP:0009428	biolink:PhenotypicFeature	Curved distal phalanx of the 3rd finger	Curved appearance of the distal phalanx of the 3rd finger.	UMLS:C4024369	hp.json	Curved outermost bone of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009428		
HP:0010424	biolink:PhenotypicFeature	Complete duplication of the distal phalanx of the 2nd toe	Complete duplication of the distal phalanx of second toe.	UMLS:C4023835	hp.json	Complete duplication of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010424		
HP:0009423	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the 3rd finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 3rd finger is affected.	UMLS:C4024372	hp.json	Bullet-shaped outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009423		
HP:0009422	biolink:PhenotypicFeature	Broad distal phalanx of the 3rd finger	Increased width of the distal phalanx of the 3rd finger.	UMLS:C4024373	hp.json	Broad outermost bone of middle finger	http://purl.obolibrary.org/obo/HP_0009422		
HP:0009425	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the 3rd finger	Uneven (irregular) increase in bone density of the distal phalanx of the third finger.	UMLS:C4024371	hp.json	Uneven increase in bone density in the outermost bone of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009425		
HP:0009424	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanx of the 3rd finger	Dissolution or degeneration of bone tissue of the distal phalanx of the 3rd finger.	UMLS:C4021478	hp.json	Lytic defect of terminal phalanx of middle finger	http://purl.obolibrary.org/obo/HP_0009424		
UBERON:0022278	biolink:AnatomicalEntity	nucleus of pudendal nerve	A nucleus in the ventral part of the anterior horn of the sacral region of the spinal cord that is the origin of the pudendal nerve.	FMA:257031|FMA:77024	hp.json	pudendal neural nucleus|nucleus of Onuf|Onuf's nucleus	http://purl.obolibrary.org/obo/UBERON_0022278		
HP:0009421	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the 3rd finger		UMLS:C4024374	hp.json	Absent/underdeveloped outermost middle finger bone|Absent/small outermost middle finger bone	http://purl.obolibrary.org/obo/HP_0009421		
HP:0009420	biolink:PhenotypicFeature	Triangular epiphyses of the 3rd finger	A triangular appearance of the epiphyses of the 3rd finger of the hand.	UMLS:C4021479	hp.json	Delta-shaped epiphyses of the 3rd finger|Triangular end part of middle finger bone	http://purl.obolibrary.org/obo/HP_0009420		
UBERON:0022279	biolink:AnatomicalEntity	strand of hair on external ear		FMA:53671	hp.json	hair of external ear|tragus hair|hair of tragus	http://purl.obolibrary.org/obo/UBERON_0022279		
CHEBI:76835	biolink:ChemicalSubstance	EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor	An EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor that uses NAD(+) or NADP(+) as acceptor (EC 1.1.1.*).		hp.json	EC 1.1.1.* inhibitor|EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+)acceptor) inhibitors|oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitors|EC 1.1.1.* inhibitors|oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitor	http://purl.obolibrary.org/obo/CHEBI_76835		3_STAR
UBERON:0010230	biolink:AnatomicalEntity	eyeball of camera-type eye	The core globe-shaped component of the camera-type eye.	MIAA:0000283|Wikipedia:Globe_(human_eye)|VHOG:0001616|SCTID:244486005|FMA:12513	hp.json	eyeball|globe|eye globe|bulbus oculi|eye	http://purl.obolibrary.org/obo/UBERON_0010230		pheno_slim
HP:0010412	biolink:PhenotypicFeature	Duplication of the middle phalanx of the 2nd toe	Partial or complete duplication of middle phalanx of second toe.	UMLS:C4021273	hp.json	Duplication of middle bone of 2nd toe|Partial/complete duplication of the middle phalanx of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010412		
HP:0010411	biolink:PhenotypicFeature	Triangular shaped middle phalanx of the 2nd toe		UMLS:C4023844	hp.json	Triangular shaped middle bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010411		
UBERON:0010231	biolink:AnatomicalEntity	anatomical line between outer ears			hp.json	otic line|inter-otic line|inter-pinna line	http://purl.obolibrary.org/obo/UBERON_0010231		
HP:0010410	biolink:PhenotypicFeature	Symphalangism affecting the middle phalanx of the 2nd toe		UMLS:C4023845	hp.json	Fused middle bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010410		
UBERON:0010234	biolink:AnatomicalEntity	palatopharyngeus muscle	The palatopharyngeus or palatopharyngeal or pharyngopalatinus muscle is a long, fleshy fasciculus, narrower in the middle than at either end, forming, with the mucous membrane covering its surface, the palatopharyngeal arch.	FMA:46666	hp.json	pharyngopalatinus muscle|pharyngopalatinus|musculus palatopharyngeus|palatopharyngeal muscle|palatopharyngeus	http://purl.obolibrary.org/obo/UBERON_0010234		
OBO:cl#has_high_plasma_membrane_amount	biolink:NamedThing	has_high_plasma_membrane_amount	A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617).		hp.json		http://purl.obolibrary.org/obo/cl#has_high_plasma_membrane_amount		
UBERON:0010235	biolink:AnatomicalEntity	uvular muscle	The musculus uvulae (azygos uvulae) is a muscle of the soft palate. It arises from the posterior nasal spine of the palatine bones and from the palatine aponeurosis. It descends to be inserted into the uvula and functions to move and shape it. It is innervated by the pharyngeal branch of the vagus nerve via the pharyngeal plexus[WP].	FMA:46733	hp.json	uvulae muscle|musculus uvulae muscle|azygos uvulae|musculus uvulae|m. uvulae|uvular muscle	http://purl.obolibrary.org/obo/UBERON_0010235		
UBERON:0010233	biolink:AnatomicalEntity	stroma of thyroid gland	The connective tissue that supports the lobules and follicles of the thyroid gland.	FMA:86304	hp.json	thyroid gland stroma|thyroid stroma	http://purl.obolibrary.org/obo/UBERON_0010233		
UBERON:0010227	biolink:AnatomicalEntity	future cardiac atrium	Multi-tissue structure that is part of the heart tube and will become the cardiac atrium.	TAO:0002228|FMA:71005|ZFA:0001718	hp.json	primordial cardiac atrium|presumptive atrium heart tube|primordial atrium	http://purl.obolibrary.org/obo/UBERON_0010227		
HP:0010419	biolink:PhenotypicFeature	Symphalangism affecting the distal phalanx of the 2nd toe		UMLS:C4023837	hp.json	Fused outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010419		
UBERON:0010225	biolink:AnatomicalEntity	thalamic complex	A nuclear complex which in mammals consists of four parts, the hypothalamus, epithalamus, ventral thalamus, and dorsal thalamus[WP,modified].	FMA:258745|EHDAA2:0004469	hp.json		http://purl.obolibrary.org/obo/UBERON_0010225		
HP:0010418	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the 2nd toe		UMLS:C4023838	hp.json	Uneven increase in bone density in the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010418		
HP:0010417	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanx of the 2nd toe		UMLS:C4023839	hp.json		http://purl.obolibrary.org/obo/HP_0010417		
HP:0009438	biolink:PhenotypicFeature	Absent middle phalanx of 3rd finger	Absence of the middle phalanx of the middle (3rd) finger.	UMLS:C4021475	hp.json	Absent middle bone of middle finger|Aplasia of the middle phalanx of the 3rd finger|Absent middle phalanx of middle finger	http://purl.obolibrary.org/obo/HP_0009438		
HP:0010416	biolink:PhenotypicFeature	Curved distal phalanx of the 2nd toe	A deviation from the normal straight form of the distal phalanx of the 2nd toe.	UMLS:C4023840	hp.json	Curved outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010416		
HP:0009437	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanx of the 3rd finger		UMLS:C4024361	hp.json	Absent/underdeveloped middle bone of the middle finger|Absent/small middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009437		
HP:0010415	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the 2nd toe	An abnormal morphology of the distal phalanx of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4023841	hp.json	Bullet-shaped outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010415		
HP:0010414	biolink:PhenotypicFeature	Broad distal phalanx of the 2nd toe		UMLS:C4023842	hp.json	Wide outermost bone of the 2nd toe|Broad outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010414		
HP:0010413	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the 2nd toe		UMLS:C4023843	hp.json	Absent/small outermost 2nd toe bone|Absent/underdeveloped outermost 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010413		
HP:0009439	biolink:PhenotypicFeature	Short middle phalanx of the 3rd finger	Hypoplasia (congenital reduction in size) of the middle phalanx of the third finger.	UMLS:C4021474	hp.json	Hypoplastic/small middle phalanx of the 3rd finger|Short middle bone of middle finger|Brachymesophalangy III (finger)	http://purl.obolibrary.org/obo/HP_0009439		
HP:0009434	biolink:PhenotypicFeature	Patchy sclerosis of the middle phalanx of the 3rd finger	Uneven (irregular) increase in bone density of the middle phalanx of the third finger.	UMLS:C4024364	hp.json	Uneven increase in bone density in the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009434		
CHEBI:15891	biolink:ChemicalSubstance	taurine	An amino sulfonic acid that is the 2-amino derivative of ethanesulfonic acid. It is a naturally occurring amino acid derived from  methionine and cysteine metabolism. An abundant component of fish- and meat-based foods, it has been used as an oral supplement in the treatment of disorders such as cystic fibrosis and hypertension.	Drug_Central:4486|PMID:21761941|PMID:3106924|PMID:15911239|PMID:2122710|DrugBank:DB01956|PMID:19309105|PMID:6198473|Gmelin:82121|PMID:17053427|PMID:27291853|PMID:8692051|PMID:11842876|PMID:11162030|PMID:7588651|PMID:2370482|Reaxys:1751215|Beilstein:1751215|PMID:15780050|PMID:10325611|PMID:2494044|CAS:107-35-7|PMID:3393260|PMID:16444816|PMID:27535560|PMID:24027187|PMID:14992292|PMID:10098958|PMID:16923232|CAS:107-35-7|PMID:18171928|PMID:19940987|PMID:9635063|PMID:16169526|PMID:10349454|CAS:107-35-7|MetaCyc:TAURINE|HMDB:HMDB0000251|PMID:19212411|Wikipedia:Taurine|PDBeChem:TAU|PMID:27334436|PMID:12297216|PMID:8818047|PMID:27412799|PMID:27380030|PMID:12834252|PMID:27345710|PMID:11918831|PMID:18060526|KEGG:C00245|PMID:17997039|PMID:11931837|PMID:17081118|KEGG:D00047|PMID:12499349|PMID:22770225|PMID:15503229|KNApSAcK:C00048188|PMID:10827156|PMID:27471162|PMID:19074966|PMID:17875433	hp.json	2-aminoethanesulfonic acid|beta-aminoethylsulfonic acid|Taurine|Aminoethylsulfonic acid|2-Aminoethanesulfonic acid|2-aminoethyl sulfonate	http://purl.obolibrary.org/obo/CHEBI_15891		3_STAR
UBERON:0022284	biolink:AnatomicalEntity	lacrimal gland bud	The single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation (Int Rev Cytol. 1996;168:1-80. Cell biology of the harderian gland).	EMAPA:35464	hp.json		http://purl.obolibrary.org/obo/UBERON_0022284		
HP:0009433	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanx of the 3rd finger	Dissolution or degeneration of bone tissue of the middle phalanx of the 3rd finger.	UMLS:C4024365	hp.json		http://purl.obolibrary.org/obo/HP_0009433		
HP:0009436	biolink:PhenotypicFeature	Triangular shaped middle phalanx of the 3rd finger	Triangular shaped middle phalanx of the 3rd (middle) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024362	hp.json	Triangular shaped middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009436		
UBERON:0022287	biolink:AnatomicalEntity	tear film	An aqueous substance that covers the anterior surface of the eyeball, keeping the cornea wet.		hp.json	precorneal film	http://purl.obolibrary.org/obo/UBERON_0022287		
HP:0009435	biolink:PhenotypicFeature	Symphalangism of middle phalanx of 3rd finger	Fusion of the middle phalanx of the 3rd finger with another bone.	UMLS:C4024363	hp.json	Fused middle bone of middle finger	http://purl.obolibrary.org/obo/HP_0009435		
HP:0009430	biolink:PhenotypicFeature	Broad middle phalanx of the 3rd finger	Increased width of the middle phalanx of the 3rd finger.	UMLS:C4021476	hp.json	Broad middle bone of middle finger|Wide/broad middle phalanx of middle-finger	http://purl.obolibrary.org/obo/HP_0009430		
UBERON:0022288	biolink:AnatomicalEntity	surface of eyeball		FMA:58315	hp.json	surface of region of wall of eyeball	http://purl.obolibrary.org/obo/UBERON_0022288		
HP:0009432	biolink:PhenotypicFeature	Curved middle phalanx of the 3rd finger	Curved appearance of the middle phalanx of the 3rd (middle) finger.	UMLS:C4024366	hp.json	Curved middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009432		
HP:0009431	biolink:PhenotypicFeature	Bullet-shaped middle phalanx of the 3rd finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 3rd finger is affected.	UMLS:C4024367	hp.json	Bullet-shaped middle bone of middle finger	http://purl.obolibrary.org/obo/HP_0009431		
HP:0010481	biolink:PhenotypicFeature	Urethral valve	The presence of an abnormal membrane obstructing the urethra.	SNOMEDCT_US:297163001|UMLS:C0266345	hp.json		http://purl.obolibrary.org/obo/HP_0010481		
HP:0009492	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the 2nd finger	Fragmented appearance of the epiphyses of the 2nd finger.	UMLS:C4024333	hp.json	Fragmentation of end part of the index finger	http://purl.obolibrary.org/obo/HP_0009492		
HP:0010480	biolink:PhenotypicFeature	Urethral fistula	The presence of an abnormal connection between the urethra and another organ or the skin.	UMLS:C0041970|SNOMEDCT_US:14981000	hp.json		http://purl.obolibrary.org/obo/HP_0010480		
HP:0009491	biolink:PhenotypicFeature	Enlarged epiphyses of the 2nd finger	Abnormally large size of the epiphyses of the 2nd finger with respect to age-dependent norms.	UMLS:C4024334	hp.json	Enlarged end part of the index finger	http://purl.obolibrary.org/obo/HP_0009491		
HP:0009494	biolink:PhenotypicFeature	Ivory epiphyses of the 2nd finger	Sclerosis of the epiphyses of the 2nd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024331	hp.json	Increased bone density of end part of the index finger bone	http://purl.obolibrary.org/obo/HP_0009494		
HP:0009493	biolink:PhenotypicFeature	Irregular epiphyses of the 2nd finger	Irregular radiographic opacity of the epiphyses of the 2nd finger.	UMLS:C4024332	hp.json	Irregular end part of the index finger	http://purl.obolibrary.org/obo/HP_0009493		
HP:0009490	biolink:PhenotypicFeature	Cone-shaped epiphyses of the 2nd finger	A cone-shaped appearance of the epiphyses of the 2nd finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.	UMLS:C4024335	hp.json	Cone-shaped end part of the index finger	http://purl.obolibrary.org/obo/HP_0009490		
HP:0010489	biolink:PhenotypicFeature	Absent palmar crease	The absence of the major creases of the palm (distal transverse crease, proximal transverse crease, or thenar crease).	UMLS:C4021262	hp.json	Absent palm lines|Absence of the palmar creases|Aplasia of the palmar creases	http://purl.obolibrary.org/obo/HP_0010489		hposlim_core
HP:0010488	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the palmar creases	Absence or underdevelopment of the palmar creases.	UMLS:C4023806	hp.json	Absent/underdeveloped palm crease|Absent/small palm crease	http://purl.obolibrary.org/obo/HP_0010488		
HP:0010487	biolink:PhenotypicFeature	Small hypothenar eminence	Reduced muscle mass on the ulnar side of the palm, that is, reduction in size of the hypothenar eminence.	UMLS:C1861395	hp.json	Hypoplasia of the hypothenar eminence|Hypothenar hypoplasia	http://purl.obolibrary.org/obo/HP_0010487		hposlim_core
HP:0010486	biolink:PhenotypicFeature	Abnormality of the hypothenar eminence	An abnormality of the hypothenar eminence, i.e., of the muscles on the ulnar side of the palm of the hand (i.e., on the side of the little finger).	UMLS:C4023807	hp.json		http://purl.obolibrary.org/obo/HP_0010486		
HP:0010485	biolink:PhenotypicFeature	Hyperextensibility at elbow	The ability of the elbow joint to move beyond its normal range of motion.	UMLS:C4023808	hp.json		http://purl.obolibrary.org/obo/HP_0010485		
HP:0010484	biolink:PhenotypicFeature	Hypertrophy of the upper limb	Abnormal increase in size of the upper limbs (due to an increase of the size of cells).	SNOMEDCT_US:298745009|UMLS:C0575518	hp.json	Increased size of upper limb	http://purl.obolibrary.org/obo/HP_0010484		
HP:0010483	biolink:PhenotypicFeature	Amniotic constriction rings of arms	Amniotic constriction rings affecting the arms.	UMLS:C4023809	hp.json		http://purl.obolibrary.org/obo/HP_0010483		
HP:0010482	biolink:PhenotypicFeature	Acromelia of the upper limbs	Shortening of the arms predominantly affecting terminal parts of the arm in relation to the upper and middle limb segments.	UMLS:C4023810	hp.json		http://purl.obolibrary.org/obo/HP_0010482		
CHEBI:15841	biolink:ChemicalSubstance	polypeptide	A peptide containing ten or more amino acid residues.	KEGG:C00403	hp.json	Polypeptide|Polypeptid|polipeptido|polypeptides	http://purl.obolibrary.org/obo/CHEBI_15841		3_STAR
HP:0009489	biolink:PhenotypicFeature	Bracket epiphyses of the 2nd finger	An abnormality of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4021466	hp.json	Bracket-epiphyses of index finger|Bracket shaped end part of index finger	http://purl.obolibrary.org/obo/HP_0009489		
HP:0009488	biolink:PhenotypicFeature	Absent epiphyses of the 2nd finger	Absence of the epiphyses of the 2nd finger.	UMLS:C4024336	hp.json	Absent end part of index finger	http://purl.obolibrary.org/obo/HP_0009488		
HP:0009485	biolink:PhenotypicFeature	Radial deviation of the hand or of fingers of the hand		UMLS:C4024337	hp.json		http://purl.obolibrary.org/obo/HP_0009485		
HP:0009484	biolink:PhenotypicFeature	Deviation of the hand or of fingers of the hand	Displacement of the hand or of fingers of the hand from their normal position.	UMLS:C4024338	hp.json	Displaced hand or fingers of the hand	http://purl.obolibrary.org/obo/HP_0009484		
HP:0009487	biolink:PhenotypicFeature	Ulnar deviation of the hand	Divergence of the longitudinal axis of the hand at the wrist in a posterior (ulnar) direction (i.e., towards the little finger).	SNOMEDCT_US:249757009|UMLS:C0241521	hp.json	Ulnar deviation of the hands|Ulnar deviation of hands	http://purl.obolibrary.org/obo/HP_0009487		hposlim_core
HP:0009486	biolink:PhenotypicFeature	Radial deviation of the hand	An abnormal position of the hand in which the wrist is bent toward the radius (i.e., toward the thumb).	SNOMEDCT_US:299035006|UMLS:C0575803	hp.json	Radial deviation of hands	http://purl.obolibrary.org/obo/HP_0009486		hposlim_core
HP:0010470	biolink:PhenotypicFeature	Supernumerary testes	The presence of more than two testes.	SNOMEDCT_US:17471001|UMLS:C0266430	hp.json	Extra testes|Polyorchidism	http://purl.obolibrary.org/obo/HP_0010470		
UBERON:0010291	biolink:AnatomicalEntity	layer of sclera	.	Wikipedia:Sclera#Histology	hp.json		http://purl.obolibrary.org/obo/UBERON_0010291		
HP:0010478	biolink:PhenotypicFeature	Abnormality of the urachus	Abnormality of the urachus.	UMLS:C4023811	hp.json		http://purl.obolibrary.org/obo/HP_0010478		
HP:0010477	biolink:PhenotypicFeature	Aplasia of the bladder	Aplasia (absence) of the urinary bladder.	UMLS:C4023812	hp.json	Absent bladder	http://purl.obolibrary.org/obo/HP_0010477		
UBERON:0010294	biolink:AnatomicalEntity	scleral endothelium	An endothelium that is part of a sclera.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010294		
HP:0010476	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the bladder	Absence or underdevelopment of the urinary bladder.	UMLS:C4023813	hp.json	Absent/small bladder|Absent/underdeveloped bladder	http://purl.obolibrary.org/obo/HP_0010476		
UBERON:0010295	biolink:AnatomicalEntity	substantia propria of sclera	A stroma that is part of a sclera.	UMLS:C1704397|FMA:58365|SCTID:368851004|NCIT:C33652	hp.json	subsantia propria|stroma of sclera|subsantia propria sclerae|scleral stroma|substantia propria sclerae	http://purl.obolibrary.org/obo/UBERON_0010295		
HP:0010475	biolink:PhenotypicFeature	Cloacal exstrophy	Cloacal exstrophy is a severe anterior abdominal wall defect in which the two hemibladders are visible and are separated by a midline intestinal plate, an omphalocele, and an imperforate anus.	SNOMEDCT_US:20815007|UMLS:C0345217	hp.json		http://purl.obolibrary.org/obo/HP_0010475		
HP:0010474	biolink:PhenotypicFeature	Bladder stones	Buildups of minerals that form in the urinary bladder.	MSH:D001744|SNOMEDCT_US:70650003|UMLS:C0005683	hp.json		http://purl.obolibrary.org/obo/HP_0010474		
MPATH:1000	biolink:NamedThing	pathological phenotype observation	Phenotypic observation of the presence or absence of a pathological entity.		hp.json		http://purl.obolibrary.org/obo/MPATH_1000		
HP:0010473	biolink:PhenotypicFeature	Porphyrinuria	Abnormally increased excretion of porphyrins in the urine.	UMLS:C0151861|SNOMEDCT_US:44574006	hp.json		http://purl.obolibrary.org/obo/HP_0010473		
HP:0010472	biolink:PhenotypicFeature	Abnormal circulating porphyrin concentration	An abnormality in the synthesis or catabolism of heme. Heme is composed of ferrous iron and protoporphyrin IX and is an essential molecule as the prosthetic group of hemeproteins such as hemoglobin, myoglobin, mitochondrial and microsomal cytochromes.	UMLS:C4023814	hp.json		http://purl.obolibrary.org/obo/HP_0010472		
HP:0010471	biolink:PhenotypicFeature	Oligosacchariduria	Increased urinary excretion of oligosaccharides (low molecular weight carbohydrate chains composed of at least three monosaccharide subunits), derived from a partial degradation of glycoproteins.	UMLS:C4023815	hp.json		http://purl.obolibrary.org/obo/HP_0010471		
UBERON:0010299	biolink:AnatomicalEntity	scleral mesenchyme	Mesenchyme surrounding the developing optic cup which develops into the sclera.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010299		
HP:0010479	biolink:PhenotypicFeature	Patent urachus	Persistence of the urachal canal resulting in a canal between the bladder and the umbilicus.	SNOMEDCT_US:398316009|UMLS:C0266357	hp.json	Persistent urachus	http://purl.obolibrary.org/obo/HP_0010479		
HP:0009499	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the 2nd finger		UMLS:C4021464	hp.json	Epiphyseal abnormality of terminal index finger phalanx|Abnormality of the end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009499		
HP:0009496	biolink:PhenotypicFeature	Small epiphyses of the 2nd finger	Abnormally small size of the epiphyses of the 2nd finger with respect to age-dependent norms.	UMLS:C4024330	hp.json	Small end part of the index finger	http://purl.obolibrary.org/obo/HP_0009496		
HP:0009495	biolink:PhenotypicFeature	Pseudoepiphysis of the 2nd finger	A secondary ossification center in the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4021465	hp.json	Accessory index finger epiphysis	http://purl.obolibrary.org/obo/HP_0009495		
HP:0009498	biolink:PhenotypicFeature	Triangular epiphyses of the 2nd finger	A triangular appearance of the epiphyses of the 2nd finger of the hand.	UMLS:C4024328	hp.json	Triangular end part of the index finger	http://purl.obolibrary.org/obo/HP_0009498		
HP:0009497	biolink:PhenotypicFeature	Stippling of the epiphyses of the 2nd finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 2nd finger.	UMLS:C4024329	hp.json	Speckled calcifications in end part of the index finger	http://purl.obolibrary.org/obo/HP_0009497		
HP:0009470	biolink:PhenotypicFeature	Contracture of the metacarpophalangeal joint of the 3rd finger	Chronic loss of joint motion of the metacarpophalangeal joint of the 3rd finger due to structural changes in non-bony tissue.	UMLS:C4024343	hp.json		http://purl.obolibrary.org/obo/HP_0009470		
UBERON:0009291	biolink:AnatomicalEntity	cartilaginous vertebral centrum	Cartilaginous form of a vertebral centrum, a skeletal element that functionally replaces the notochord[VSAP,modified].		hp.json	cartilaginous centrum of vertebra|postcaudal cartilaginous centrum	http://purl.obolibrary.org/obo/UBERON_0009291		
HP:0009471	biolink:PhenotypicFeature	Contracture of the proximal interphalangeal joint of the 3rd finger	Chronic loss of joint motion of the proximal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue.	UMLS:C4021467	hp.json	Camptodactyly of the 3rd finger|Camptodactyly of the third finger	http://purl.obolibrary.org/obo/HP_0009471		
UBERON:0009292	biolink:AnatomicalEntity	embryonic nasal process		EHDAA:4776|EMAPA:16680|FMA:293971|EHDAA2:0000581	hp.json	nasal placode	http://purl.obolibrary.org/obo/UBERON_0009292		
UBERON:0010285	biolink:AnatomicalEntity	midbrain basal plate	Portion of tissue that is dorsolateral to the floor plate and part of the midbrain.	EFO:0003567|EHDAA2:0004375|ZFA:0000761|DHBA:12322|TAO:0000761	hp.json	basal plate midbrain|basal plate midbrain region	http://purl.obolibrary.org/obo/UBERON_0010285		efo_slim
UBERON:0010286	biolink:AnatomicalEntity	midbrain neural tube	Portion of neural tube that gives rise to the midbrain.	TAO:0007039|ZFA:0007039	hp.json		http://purl.obolibrary.org/obo/UBERON_0010286		
HP:0010465	biolink:PhenotypicFeature	Precocious puberty in females	The onset of puberty before the age of 8 years in girls.	SNOMEDCT_US:19911007|UMLS:C0271616	hp.json		http://purl.obolibrary.org/obo/HP_0010465		
HP:0010464	biolink:PhenotypicFeature	Streak ovary	A developmental disorder characterized by the progressive loss of primordial germ cells in the developing ovaries of an embryo, leading to hypoplastic ovaries composed of wavy connective tissue with occasional clumps of granulosa cells, and frequently mesonephric or hilar cells.	UMLS:C0266371|SNOMEDCT_US:70550008	hp.json		http://purl.obolibrary.org/obo/HP_0010464		
UBERON:0010284	biolink:AnatomicalEntity	lacrimal punctum	A minute orifice on the summit of the papillae lacrimales, which is the commencement point of the lacrimal canaliculi.	FMA:59365	hp.json	lacrimal point|lacrimal puncta|puncta lacrimalia	http://purl.obolibrary.org/obo/UBERON_0010284		pheno_slim
HP:0010463	biolink:PhenotypicFeature	Aplasia of the ovary	Aplasia, that is failure to develop, of the ovary.	UMLS:C0266368|SNOMEDCT_US:12017008	hp.json	Absent ovary|Aplasia of the ovaries|Bilateral absent ovaries	http://purl.obolibrary.org/obo/HP_0010463		
HP:0010462	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the ovary	Aplasia or developmental hypoplasia of the ovary.	UMLS:C4023818	hp.json	Absent/underdeveloped ovary|Absent/small ovary	http://purl.obolibrary.org/obo/HP_0010462		
HP:0010461	biolink:PhenotypicFeature	Abnormality of the male genitalia	Abnormality of the male genital system.	UMLS:C4023819	hp.json	Abnormality of the male genitalia|Abnormal male genitals	http://purl.obolibrary.org/obo/HP_0010461		
HP:0010460	biolink:PhenotypicFeature	Abnormality of the female genitalia	Abnormality of the female genital system.	UMLS:C4023820	hp.json		http://purl.obolibrary.org/obo/HP_0010460		
HP:0010469	biolink:PhenotypicFeature	Absent testis	Testis not palpable in the scrotum or inguinal canal.	UMLS:C4023816	hp.json	Absent testes|Aplasia of the testes|Absence of palpable testicules	http://purl.obolibrary.org/obo/HP_0010469		
HP:0010468	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the testes	Absence or underdevelopment of the testes.	UMLS:C4023817	hp.json	Absent/underdeveloped testes|Absent/small testes	http://purl.obolibrary.org/obo/HP_0010468		
HP:0009467	biolink:PhenotypicFeature	Radial deviation of the 2nd finger	Displacement of the 2nd finger towards the radial side.	UMLS:C1844709	hp.json	Radially deviated index finger	http://purl.obolibrary.org/obo/HP_0009467		
HP:0009466	biolink:PhenotypicFeature	Radial deviation of finger	Bending or curvature of a finger toward the radial side (i.e., towards the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly.	UMLS:C1836189	hp.json	Radially deviated fingers|Radially deviated phalanges	http://purl.obolibrary.org/obo/HP_0009466		hposlim_core
HP:0009469	biolink:PhenotypicFeature	Contracture of the distal interphalangeal joint of the 3rd finger	Chronic loss of joint motion of the distal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue.	UMLS:C4024344	hp.json	Contracture of the outermost hinge joint of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009469		
HP:0009468	biolink:PhenotypicFeature	Deviation of the 2nd finger	Displacement of the 2nd finger from its normal position.	UMLS:C4021468	hp.json	Displaced index finger|Deviated index finger	http://purl.obolibrary.org/obo/HP_0009468		
HP:0009463	biolink:PhenotypicFeature	Ulnar deviation of the 3rd finger	Displacement of the 3rd finger towards the ulnar side (i.e., towards the ring finger).	UMLS:C3554614	hp.json	Ulnar deviation of middle fingers	http://purl.obolibrary.org/obo/HP_0009463		
HP:0009462	biolink:PhenotypicFeature	Radial deviation of the 3rd finger	Displacement of the 3rd finger towards the radial side (i.e., towards the thumb).	UMLS:C4024345	hp.json	Inward turned middle finger	http://purl.obolibrary.org/obo/HP_0009462		
HP:0009465	biolink:PhenotypicFeature	Ulnar deviation of finger	Bending or curvature of a finger toward the ulnar side (i.e., away from the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly.	SNOMEDCT_US:367510009|SNOMEDCT_US:276662009|UMLS:C0231679	hp.json	Finger bends toward pinky|Ulnar Drift	http://purl.obolibrary.org/obo/HP_0009465		hposlim_core
UBERON:0022236	biolink:AnatomicalEntity	peduncle of thalamus		MBA:365	hp.json	thalamic peduncle	http://purl.obolibrary.org/obo/UBERON_0022236		
HP:0009464	biolink:PhenotypicFeature	Ulnar deviation of the 2nd finger	Displacement of the 2nd (index) finger towards the ulnar side.	UMLS:C1844891	hp.json	Ulnar angulation of the index finger|Ulnar deviation of index fingers|Medially deviated index finger|Second finger ulnar deviation	http://purl.obolibrary.org/obo/HP_0009464		
UBERON:0022235	biolink:AnatomicalEntity	peduncle of diencephalon		FMA:62444	hp.json	diencephalon peduncle	http://purl.obolibrary.org/obo/UBERON_0022235		
HP:0009483	biolink:PhenotypicFeature	Symphalangism of the proximal phalanx of the 3rd finger with the 3rd metacarpal	Fusion of the proximal phalanx of the 3rd finger with the 3rd metacarpal.	UMLS:C4024339	hp.json	Fused innermost bones of middle finger with middle long bone of hand	http://purl.obolibrary.org/obo/HP_0009483		
NCBITaxon:2698737	biolink:OrganismalEntity	Sar		GC_ID:1	hp.json	SAR supergroup	http://purl.obolibrary.org/obo/NCBITaxon_2698737		
HP:0009482	biolink:PhenotypicFeature	Proximal/middle symphalangism of 3rd finger	Fusion of the proximal and middle phalanges of the 3rd finger.	UMLS:C4024340	hp.json	Fused of innermost and middle bones of middle finger	http://purl.obolibrary.org/obo/HP_0009482		
HP:0010456	biolink:PhenotypicFeature	Abnormal greater sciatic notch morphology	An abnormality of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium.	UMLS:C4023822	hp.json	Abnormality of the greater sacrosciatic notch|Abnormality of the sacroiliac notch|Abnormality of greater sciatic notch	http://purl.obolibrary.org/obo/HP_0010456		
HP:0010455	biolink:PhenotypicFeature	Steep acetabular roof	An exaggeration of the normal arched form of the acetabular roof such that it takes on a steep appearance.	UMLS:C3150931	hp.json		http://purl.obolibrary.org/obo/HP_0010455		
HP:0010454	biolink:PhenotypicFeature	Acetabular spurs	The presence of osteophytes (bone spurs), i.e., of bony projections originating from the acetabulum.	UMLS:C3808270	hp.json		http://purl.obolibrary.org/obo/HP_0010454		hposlim_core
UBERON:0010272	biolink:AnatomicalEntity	hyoid apparatus	A group of bones comprised of hyoid body and two pairs of cornua (i.e. greater cornua and lesser cornua), and lies just below the tongue, above the thyroid cartilage.	EMAPA:37600|http://palaeos.com/vertebrates/bones/gill_arches/images/ReptileHyoids.gif|AAO:0000682|SCTID:410035009|MA:0003037|AAO:0000225	hp.json	apparatus hyobranchialis|hyobranchial apparatus|hyolingual system|apparatus hyoideus|apparatus hyoideus	http://purl.obolibrary.org/obo/UBERON_0010272		
HP:0010453	biolink:PhenotypicFeature	Pelvic bone asymmetry	Pelvic asymmetry refers to asymmetric positioning of landmarks on the two sides of the pelvis and may have a structural or functional etiology.	UMLS:C4021263	hp.json	Asymmetric pelvis|Pelvic asymmetry	http://purl.obolibrary.org/obo/HP_0010453		hposlim_core
UBERON:0010273	biolink:AnatomicalEntity	zone of hyoid bone	A zone of bone organ that is part of a hyoid bone.	SCTID:119534005|FMA:59494	hp.json	hyoid bone zone	http://purl.obolibrary.org/obo/UBERON_0010273		
HP:0010452	biolink:PhenotypicFeature	Ectopia of the spleen	An abnormal (non-anatomic) location of the spleen.	UMLS:C0266632|SNOMEDCT_US:65146007	hp.json	Ectopic spleen|Abnormal spleen location	http://purl.obolibrary.org/obo/HP_0010452		
HP:0010451	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the spleen	Absence or underdevelopment of the spleen.	UMLS:C4023823	hp.json	Absent/underdeveloped spleen|Absent/small spleen	http://purl.obolibrary.org/obo/HP_0010451		
UBERON:0010276	biolink:AnatomicalEntity	space in vertebral column	Any anatomical space that is part of a vertebral column.	AAO:0000700	hp.json	vertebral conduit|vertebral column opening	http://purl.obolibrary.org/obo/UBERON_0010276		
HP:0010450	biolink:PhenotypicFeature	Esophageal stenosis	An abnormal narrowing of the lumen of the esophagus.	SNOMEDCT_US:63305008|MSH:D004940|UMLS:C0014866	hp.json	Narrowing of the oesophagus|Narrowing of the esophagus	http://purl.obolibrary.org/obo/HP_0010450		
HP:0010459	biolink:PhenotypicFeature	True hermaphroditism	The presence of both ovarian and testicular tissues either in the same or in opposite gonads. Affected persons have ambiguous genitalia and may have 46,XX or 46,XY karyotypes or 46,XX/XY mosaicism.	MSH:D050090|SNOMEDCT_US:18978002|UMLS:C0266361	hp.json	Testicular and ovarian tissue present	http://purl.obolibrary.org/obo/HP_0010459		
HP:0010458	biolink:PhenotypicFeature	Female pseudohermaphroditism	Hermaphroditism refers to a discrepancy between the morphology of the gonads and that of the external genitalia. In female pseudohermaphroditism, the genotype is female (XX) and the gonads are ovaries, but the external genitalia are virilized.	SNOMEDCT_US:8800006|UMLS:C0238394|MSH:D058489	hp.json		http://purl.obolibrary.org/obo/HP_0010458		
HP:0010457	biolink:PhenotypicFeature	obsolete Widening of the sacrosciatic notch			hp.json		http://purl.obolibrary.org/obo/HP_0010457		
HP:0009478	biolink:PhenotypicFeature	Symphalangism of the proximal phalanx of the 4th finger with the 4th metacarpal	Fusion of the proximal phalanx of the 4th finger with the 4th metacarpal.	UMLS:C4024341	hp.json	Fused innermost bone of ring finger with 4th long bone of hand	http://purl.obolibrary.org/obo/HP_0009478		
HP:0009477	biolink:PhenotypicFeature	Proximal/middle symphalangism of 4th finger	Fusion of the proximal and middle phalanges of the 4th finger.	UMLS:C4024342	hp.json	Fused innermost and middle bone of fourth finger	http://purl.obolibrary.org/obo/HP_0009477		
CHEBI:76874	biolink:ChemicalSubstance	EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor	An EC 2.1.* (C1-transferase) inhibitor that interferes with the action of any hydroxymethyl-, formyl- and related transferase (EC 2.1.2.*).		hp.json	EC 2.1.2.* inhibitors|hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitor|EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitors|hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitors|EC 2.1.2.* inhibitor	http://purl.obolibrary.org/obo/CHEBI_76874		3_STAR
HP:0009473	biolink:PhenotypicFeature	Joint contracture of the hand	Contractures of one ore more joints of the hands meaning chronic loss of joint motion due to structural changes in non-bony tissue.	UMLS:C0158113|SNOMEDCT_US:86414002|MEDDRA:10010821	hp.json	Contractures of the hands|Contractures involving the hands	http://purl.obolibrary.org/obo/HP_0009473		hposlim_core
GO:1902018	biolink:BiologicalProcess	negative regulation of cilium assembly	Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.		hp.json	down-regulation of cilium biogenesis|negative regulation of cilium biogenesis|downregulation of ciliogenesis|down regulation of cilium biogenesis|down-regulation of cilium assembly|down regulation of ciliogenesis|downregulation of cilium biogenesis|down-regulation of ciliogenesis|down regulation of cilium assembly|negative regulation of ciliogenesis|downregulation of cilium assembly|inhibition of ciliogenesis|inhibition of cilium biogenesis|inhibition of cilium assembly	http://purl.obolibrary.org/obo/GO_1902018		
GO:1902019	biolink:BiologicalProcess	regulation of cilium-dependent cell motility	Any process that modulates the frequency, rate or extent of cilium-dependent cell motility.		hp.json	regulation of cilium cell motility|regulation of ciliary cell motility	http://purl.obolibrary.org/obo/GO_1902019		
GO:1902017	biolink:BiologicalProcess	regulation of cilium assembly	Any process that modulates the frequency, rate or extent of cilium assembly.		hp.json	regulation of ciliogenesis|regulation of cilium biogenesis	http://purl.obolibrary.org/obo/GO_1902017		
GO:1904677	biolink:BiologicalProcess	positive regulation of somatic stem cell division	Any process that activates or increases the frequency, rate or extent of somatic stem cell division.		hp.json	upregulation of somatic stem cell renewal|up regulation of somatic stem cell division|up-regulation of somatic stem cell division|activation of somatic stem cell division|up-regulation of somatic stem cell renewal|up regulation of somatic stem cell renewal|positive regulation of somatic stem cell renewal|activation of somatic stem cell renewal|upregulation of somatic stem cell division	http://purl.obolibrary.org/obo/GO_1904677		
GO:1904676	biolink:BiologicalProcess	negative regulation of somatic stem cell division	Any process that stops, prevents or reduces the frequency, rate or extent of somatic stem cell division.		hp.json	down-regulation of somatic stem cell renewal|negative regulation of somatic stem cell renewal|down regulation of somatic stem cell renewal|downregulation of somatic stem cell division|inhibition of somatic stem cell renewal|downregulation of somatic stem cell renewal|down regulation of somatic stem cell division|inhibition of somatic stem cell division|down-regulation of somatic stem cell division	http://purl.obolibrary.org/obo/GO_1904676		
GO:1904675	biolink:BiologicalProcess	regulation of somatic stem cell division	Any process that modulates the frequency, rate or extent of somatic stem cell division.		hp.json	regulation of somatic stem cell renewal	http://purl.obolibrary.org/obo/GO_1904675		
GO:0015931	biolink:BiologicalProcess	nucleobase-containing compound transport	The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	nucleobase, nucleoside, nucleotide and nucleic acid transport	http://purl.obolibrary.org/obo/GO_0015931		goslim_pir|goslim_yeast
GO:1902020	biolink:BiologicalProcess	negative regulation of cilium-dependent cell motility	Any process that stops, prevents or reduces the frequency, rate or extent of cilium-dependent cell motility.		hp.json	negative regulation of cilium cell motility|down-regulation of ciliary cell motility|down regulation of ciliary cell motility|negative regulation of ciliary cell motility|inhibition of ciliary cell motility|downregulation of ciliary cell motility	http://purl.obolibrary.org/obo/GO_1902020		
CHEBI:50248	biolink:ChemicalSubstance	hematologic agent	Drug that acts on blood and blood-forming organs and those that affect the hemostatic system.		hp.json	hematologic agents	http://purl.obolibrary.org/obo/CHEBI_50248		3_STAR
CHEBI:50249	biolink:ChemicalSubstance	anticoagulant	An agent that prevents blood clotting.		hp.json	anticoagulante|anticoagulants	http://purl.obolibrary.org/obo/CHEBI_50249		3_STAR
GO:1902033	biolink:BiologicalProcess	regulation of hematopoietic stem cell proliferation	Any process that modulates the frequency, rate or extent of hematopoietic stem cell proliferation.		hp.json	regulation of hemopoietic stem cell proliferation	http://purl.obolibrary.org/obo/GO_1902033		
GO:1904693	biolink:BiologicalProcess	midbrain morphogenesis	The developmental process by which a midbrain is generated and organized.		hp.json	MB morphogenesis|mesencephalon morphogenesis	http://purl.obolibrary.org/obo/GO_1904693		
GO:1902038	biolink:BiologicalProcess	positive regulation of hematopoietic stem cell differentiation	Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell differentiation.		hp.json	upregulation of haemopoietic stem cell differentiation|positive regulation of haematopoietic stem cell differentiation|up-regulation of hematopoietic stem cell differentiation|up regulation of haematopoietic stem cell differentiation|positive regulation of haemopoietic stem cell differentiation|up regulation of hematopoietic stem cell differentiation|up-regulation of hemopoietic stem cell differentiation|activation of hematopoietic stem cell differentiation|activation of haematopoietic stem cell differentiation|up-regulation of haematopoietic stem cell differentiation|up regulation of haemopoietic stem cell differentiation|up regulation of hemopoietic stem cell differentiation|activation of hemopoietic stem cell differentiation|up-regulation of haemopoietic stem cell differentiation|positive regulation of hemopoietic stem cell differentiation|activation of haemopoietic stem cell differentiation|upregulation of hematopoietic stem cell differentiation|upregulation of hemopoietic stem cell differentiation|upregulation of haematopoietic stem cell differentiation	http://purl.obolibrary.org/obo/GO_1902038		
GO:1902036	biolink:BiologicalProcess	regulation of hematopoietic stem cell differentiation	Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.		hp.json	regulation of hemopoietic stem cell differentiation|regulation of haematopoietic stem cell differentiation|regulation of haemopoietic stem cell differentiation	http://purl.obolibrary.org/obo/GO_1902036		
GO:1902037	biolink:BiologicalProcess	negative regulation of hematopoietic stem cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.		hp.json	inhibition of hematopoietic stem cell differentiation|downregulation of hematopoietic stem cell differentiation|downregulation of hemopoietic stem cell differentiation|inhibition of hemopoietic stem cell differentiation|downregulation of haematopoietic stem cell differentiation|downregulation of haemopoietic stem cell differentiation|down regulation of haematopoietic stem cell differentiation|down-regulation of hematopoietic stem cell differentiation|inhibition of haematopoietic stem cell differentiation|down regulation of hematopoietic stem cell differentiation|down-regulation of hemopoietic stem cell differentiation|down regulation of haemopoietic stem cell differentiation|negative regulation of hemopoietic stem cell differentiation|down-regulation of haematopoietic stem cell differentiation|negative regulation of haematopoietic stem cell differentiation|inhibition of haemopoietic stem cell differentiation|down regulation of hemopoietic stem cell differentiation|down-regulation of haemopoietic stem cell differentiation|negative regulation of haemopoietic stem cell differentiation	http://purl.obolibrary.org/obo/GO_1902037		
GO:1902034	biolink:BiologicalProcess	negative regulation of hematopoietic stem cell proliferation	Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell proliferation.		hp.json	down-regulation of hematopoietic stem cell proliferation|down-regulation of hemopoietic stem cell proliferation|down regulation of hematopoietic stem cell proliferation|negative regulation of hemopoietic stem cell proliferation|down regulation of hemopoietic stem cell proliferation|inhibition of hematopoietic stem cell proliferation|downregulation of hematopoietic stem cell proliferation|inhibition of hemopoietic stem cell proliferation|downregulation of hemopoietic stem cell proliferation	http://purl.obolibrary.org/obo/GO_1902034		
GO:1902035	biolink:BiologicalProcess	positive regulation of hematopoietic stem cell proliferation	Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell proliferation.		hp.json	activation of hemopoietic stem cell proliferation|positive regulation of hemopoietic stem cell proliferation|upregulation of hematopoietic stem cell proliferation|upregulation of hemopoietic stem cell proliferation|up-regulation of hematopoietic stem cell proliferation|up regulation of hematopoietic stem cell proliferation|up-regulation of hemopoietic stem cell proliferation|activation of hematopoietic stem cell proliferation|up regulation of hemopoietic stem cell proliferation	http://purl.obolibrary.org/obo/GO_1902035		
CHEBI:25274	biolink:ChemicalSubstance	methylamines			hp.json	methylated amines	http://purl.obolibrary.org/obo/CHEBI_25274		3_STAR
CHEBI:37257	biolink:ChemicalSubstance	phytanate	A branched-chain saturated fatty acid anion that is the conjugate base of phytanic acid, arising from deprotonation of the carboxylic acid group.	KEGG:C01607|PMID:5130448|Reaxys:3669982|Beilstein:3669982	hp.json	3,7,11,15-tetramethylpalmitate|phytanate anion|3,7,11,15-tetramethylhexadecanoate|3,7,11,15-tetramethylhexadecanoate	http://purl.obolibrary.org/obo/CHEBI_37257		3_STAR
GO:0015925	biolink:MolecularActivity	galactosidase activity	Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative.		hp.json		http://purl.obolibrary.org/obo/GO_0015925		
HP:0010401	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanx of the 2nd toe		UMLS:C4023853	hp.json	Fused innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010401		
UBERON:0010220	biolink:AnatomicalEntity	arytenoid pre-cartilage condensation		EMAPA:17387|EHDAA2:0000144|VHOG:0000998	hp.json	arytenoid swelling pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010220		
HP:0010400	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the 2nd toe		UMLS:C4023854	hp.json	Uneven increase in bone density in the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010400		
UBERON:0010223	biolink:AnatomicalEntity	left pupil	A pupil that is part of a left eye.	FMA:58254	hp.json	pupil of left eye	http://purl.obolibrary.org/obo/UBERON_0010223		
UBERON:0010224	biolink:AnatomicalEntity	right pupil	A pupil that is part of a right eye.	FMA:58253	hp.json	pupil of right eye	http://purl.obolibrary.org/obo/UBERON_0010224		
UBERON:0010221	biolink:AnatomicalEntity	laryngeal associated mesenchyme		EHDAA2:0004085	hp.json		http://purl.obolibrary.org/obo/UBERON_0010221		
UBERON:0010222	biolink:AnatomicalEntity	anatomical line between pupils			hp.json	inter-pupillary line|interpupillary line	http://purl.obolibrary.org/obo/UBERON_0010222		pheno_slim
HP:0010409	biolink:PhenotypicFeature	Patchy sclerosis of the middle phalanx of the 2nd toe		UMLS:C4023846	hp.json	Uneven increase in bone density in the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010409		
HP:0010408	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanx of the 2nd toe		UMLS:C4023847	hp.json		http://purl.obolibrary.org/obo/HP_0010408		
HP:0009408	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the 4th finger		UMLS:C4024384	hp.json	Absent/small ring finger bones|Absent/underdeveloped ring finger bones	http://purl.obolibrary.org/obo/HP_0009408		
UBERON:0010214	biolink:AnatomicalEntity	cricoid pre-cartilage condensation		EHDAA2:0000327	hp.json		http://purl.obolibrary.org/obo/UBERON_0010214		
HP:0010407	biolink:PhenotypicFeature	Curved middle phalanx of the 2nd toe	A deviation from the normal straight form of the middle phalanx of the 2nd toe.	UMLS:C4023848	hp.json	Curved middle bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010407		
HP:0010406	biolink:PhenotypicFeature	Bullet-shaped middle phalanx of the 2nd toe	An abnormal morphology of the middle phalanx of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4023849	hp.json	Bullet-shaped middle bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010406		
UBERON:0010215	biolink:AnatomicalEntity	arytenoid swellings	Paired primordial elevations, on either side of the embryonic larynx, within which the arytenoid cartilages are formed.	EHDAA2:0000146	hp.json		http://purl.obolibrary.org/obo/UBERON_0010215		
HP:0010405	biolink:PhenotypicFeature	Broad middle phalanx of the 2nd toe		UMLS:C4023850	hp.json	Broad middle bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010405		
HP:0009405	biolink:PhenotypicFeature	Bullet-shaped phalanges of the 4th finger	A fourth finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4024386	hp.json	Bullet-shaped of bone of ring finger	http://purl.obolibrary.org/obo/HP_0009405		
HP:0010404	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanx of the 2nd toe		UMLS:C4023851	hp.json	Absent/underdeveloped middle bone of 2nd toe|Absent/small middle bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010404		
HP:0009404	biolink:PhenotypicFeature	Broad phalanges of the 4th finger	Increased width of the phalanges of the 4th finger.	UMLS:C4024387	hp.json	Broad bones of ring finger	http://purl.obolibrary.org/obo/HP_0009404		
HP:0009407	biolink:PhenotypicFeature	Triangular shaped phalanges of the 4th finger	Triangular shaped phalanges of the 4th finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024385	hp.json	Triangular shaped bone of ring finger	http://purl.obolibrary.org/obo/HP_0009407		
HP:0010403	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the 2nd toe	Partial or complete duplication of proximal phalanx of second toe.	UMLS:C4021274	hp.json	Duplication of the proximal phalanx of the second toe|Partial/complete duplication of the proximal phalanx of the 2nd toe|Duplication of innermost 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010403		
HP:0009406	biolink:PhenotypicFeature	Patchy sclerosis of 4th finger phalanx	Uneven increase in bone density of one or more of the phalanges of the fourth (ring) finger.	UMLS:C4021481	hp.json	Uneven increase in bone density in ring finger bone|Patchy sclerosis of the phalanges of the 4th finger	http://purl.obolibrary.org/obo/HP_0009406		
UBERON:0010219	biolink:AnatomicalEntity	thyroid pre-cartilage condensation		EHDAA2:0004088	hp.json		http://purl.obolibrary.org/obo/UBERON_0010219		
HP:0010402	biolink:PhenotypicFeature	Triangular shaped proximal phalanx of the 2nd toe		UMLS:C4023852	hp.json	Triangular shaped innermost 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010402		
HP:0009401	biolink:PhenotypicFeature	Small epiphyses of the 4th finger	Abnormally small size of the epiphyses of the 4th finger with respect to age-dependent norms.	UMLS:C4024389	hp.json	Small end part of ring finger bone	http://purl.obolibrary.org/obo/HP_0009401		
HP:0009400	biolink:PhenotypicFeature	Pseudoepiphyses of the 4th finger	A secondary ossification center in the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024390	hp.json		http://purl.obolibrary.org/obo/HP_0009400		
HP:0009403	biolink:PhenotypicFeature	Triangular epiphyses of the 4th finger	A triangular appearance of the epiphyses of the 4th finger of the hand.	UMLS:C4021482	hp.json	Delta-shaped epiphyses of the 4th finger|Triangular end part of ring finger bone	http://purl.obolibrary.org/obo/HP_0009403		
HP:0009402	biolink:PhenotypicFeature	Stippling of the epiphyses of the 4th finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 4th finger.	UMLS:C4024388	hp.json	Speckled calcifications in end part of ring finger bone	http://purl.obolibrary.org/obo/HP_0009402		
UBERON:0010212	biolink:AnatomicalEntity	laryngeal apparatus	Apparatus located between the lungs and the buccal cavity. This apparatus is composed of a pair of arytenoid cartilages that are supported by the cricoid ring.	EHDAA2:0000904|AAO:0000267	hp.json	laryngeal cartilage system	http://purl.obolibrary.org/obo/UBERON_0010212		
UBERON:0010213	biolink:AnatomicalEntity	laryngeal pre-cartilage condensation			hp.json		http://purl.obolibrary.org/obo/UBERON_0010213		
HP:0009419	biolink:PhenotypicFeature	Stippling of the epiphyses of the 3rd finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 3rd finger.	UMLS:C4024375	hp.json	Speckled calcifications in end part of middle finger bone	http://purl.obolibrary.org/obo/HP_0009419		
CHEBI:37246	biolink:ChemicalSubstance	elemental sodium			hp.json		http://purl.obolibrary.org/obo/CHEBI_37246		3_STAR
UBERON:0010204	biolink:AnatomicalEntity	tail vasculature	A vasculature that is part of a post-anal tail.	TAO:0005037|XAO:0004151|ZFA:0005037	hp.json	tail vasculature|post-vent vasculature	http://purl.obolibrary.org/obo/UBERON_0010204		
CHEBI:37247	biolink:ChemicalSubstance	elemental potassium			hp.json		http://purl.obolibrary.org/obo/CHEBI_37247		3_STAR
HP:0009416	biolink:PhenotypicFeature	Ivory epiphyses of the 3rd finger	Sclerosis of the epiphyses of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024377	hp.json	Increased bone density of end part of the middle finger bone	http://purl.obolibrary.org/obo/HP_0009416		
HP:0009415	biolink:PhenotypicFeature	Irregular epiphyses of the 3rd finger	Irregular radiographic opacity of the epiphyses of the 3rd finger.	UMLS:C4024378	hp.json	Irregular end part of middle finger bone	http://purl.obolibrary.org/obo/HP_0009415		
HP:0009418	biolink:PhenotypicFeature	Small epiphyses of the 3rd finger	Abnormally small size of the epiphyses of the 3rd finger with respect to age-dependent norms.	UMLS:C4024376	hp.json	Small end part of middle finger bone	http://purl.obolibrary.org/obo/HP_0009418		
HP:0009417	biolink:PhenotypicFeature	Pseudoepiphyses of the 3rd finger	A secondary ossification center in the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4021480	hp.json	Pseudoepiphyses of middle finger phalanges	http://purl.obolibrary.org/obo/HP_0009417		
HP:0009412	biolink:PhenotypicFeature	Cone-shaped epiphyses of the 3rd finger	A cone-shaped appearance of the epiphyses of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.	UMLS:C4024381	hp.json	Cone-shaped end part of middle finger bone	http://purl.obolibrary.org/obo/HP_0009412		
HP:0009411	biolink:PhenotypicFeature	Bracket epiphyses of the 3rd finger	An abnormality of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024382	hp.json	Bracket shaped end part of middle finger bone	http://purl.obolibrary.org/obo/HP_0009411		
HP:0009414	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the 3rd finger	Fragmented appearance of the epiphyses of the 3rd finger.	UMLS:C4024379	hp.json	Fragmentation of end part of middle finger bone	http://purl.obolibrary.org/obo/HP_0009414		
HP:0009413	biolink:PhenotypicFeature	Enlarged epiphyses of the 3rd finger	Abnormally large size of the epiphyses of the 3rd finger with respect to age-dependent norms.	UMLS:C4024380	hp.json	Enlarged end part of middle finger bone	http://purl.obolibrary.org/obo/HP_0009413		
HP:0009410	biolink:PhenotypicFeature	Absent epiphyses of the 3rd finger	Absence of the epiphyses of the 3rd finger.	UMLS:C4024383	hp.json	Absent end part of middle finger bone	http://purl.obolibrary.org/obo/HP_0009410		
CHEBI:25235	biolink:ChemicalSubstance	monomethoxybenzene	Compounds containing a benzene skeleton substituted with one methoxy group.		hp.json	monomethoxybenzenes	http://purl.obolibrary.org/obo/CHEBI_25235		3_STAR
CHEBI:27897	biolink:ChemicalSubstance	tryptophan	An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	PMID:17439666|KEGG:C00806|LINCS:LSM-36836|Wikipedia:Tryptophan|Gmelin:4532|Beilstein:86196|CAS:54-12-6|Reaxys:86196|CAS:54-12-6|CAS:54-12-6|PMID:22264337|KNApSAcK:C00001396	hp.json	W|tryptophan|alpha-Amino-beta-(3-indolyl)-propionic acid|Trp|Tryptophan|tryptophane|alpha-amino-beta-3-indolepropionic acid|beta-3-indolylalanine|2-amino-3-(1H-indol-3-yl)propanoic acid|triptofano|Htrp	http://purl.obolibrary.org/obo/CHEBI_27897		3_STAR
UBERON:0009210	biolink:AnatomicalEntity	pharyngeal membrane	A thin fold of ectoderm and endoderm that separates the pharyngeal pouches from the pharyngeal clefts in a developing embryo.	NCIT:C34251|UMLS:C1519040|EMAPA:32749|FMA:295758	hp.json	pharyngeal membrane|branchial arch membrane|branchial membrane	http://purl.obolibrary.org/obo/UBERON_0009210		pheno_slim
UBERON:0009213	biolink:AnatomicalEntity	pharyngeal membrane of 1st arch	A pharyngeal membrane that separates the first pharyngeal cleft from the first pharyngeal pouch.	EMAPA:16121|VHOG:0001427|EMAPA:17281|EMAPA:16992|EHDAA:3788	hp.json	tympanic membrane primordium|1st pharyngeal membrane|1st branchial membrane|future tympanic membrane	http://purl.obolibrary.org/obo/UBERON_0009213		
CHEBI:52845	biolink:ChemicalSubstance	cyclic organic group	An organic group that consists of a closed ring. It may be a substituent or a skeleton.		hp.json	cyclic organic groups	http://purl.obolibrary.org/obo/CHEBI_52845		3_STAR
UBERON:0009205	biolink:AnatomicalEntity	lateral nasal process mesenchyme	Mesenchyme that is part of a lateral nasal prominence.	EMAPA:16807|EHDAA2:0000917|FMA:312665	hp.json	mesenchyme of latero-nasal process	http://purl.obolibrary.org/obo/UBERON_0009205		
UBERON:0009206	biolink:AnatomicalEntity	lateral nasal process surface ectoderm	An ectoderm that is part of a lateral nasal prominence.	EMAPA:16806|EHDAA2:0000918	hp.json	ectoderm of latero-nasal process	http://purl.obolibrary.org/obo/UBERON_0009206		
GO:1902093	biolink:NamedThing	positive regulation of flagellated sperm motility			hp.json		http://purl.obolibrary.org/obo/GO_1902093		
UBERON:0009200	biolink:AnatomicalEntity	limb epidermis	The limb epidermis is the outer epithelial layer of the limb, it is a complex stratified squamous epithelium.	EMAPA:32728	hp.json		http://purl.obolibrary.org/obo/UBERON_0009200		
UBERON:0009201	biolink:AnatomicalEntity	nephric duct	A nephric duct is a tube that drains a primitive kidney[GO].	EMAPA:16577	hp.json		http://purl.obolibrary.org/obo/UBERON_0009201		
UBERON:0009203	biolink:AnatomicalEntity	internasal suture	A suture joining the nasal bones.	FMA:52959	hp.json	internasal suture of skull|sutura internasalis|sutura internasalis|inter-nasal suture|nasal suture	http://purl.obolibrary.org/obo/UBERON_0009203		
UBERON:0009204	biolink:AnatomicalEntity	medial nasal process mesenchyme	Mesenchyme that is part of a medial nasal prominence.	FMA:312659|EHDAA2:0001077|EMAPA:16810	hp.json		http://purl.obolibrary.org/obo/UBERON_0009204		
CL:0000127	biolink:Cell	astrocyte	A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury.	BTO:0000099|FMA:54537|CALOHA:TS-0060	hp.json	astrocytic glia	http://purl.obolibrary.org/obo/CL_0000127		
CL:0000128	biolink:Cell	oligodendrocyte	A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.	BTO:0000962|FMA:54540|CALOHA:TS-0709	hp.json	OLs|oligodendroglia	http://purl.obolibrary.org/obo/CL_0000128		
CL:0000129	biolink:Cell	microglial cell	A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.	BTO:0000962|BTO:0000078|FMA:54540|FMA:54539	hp.json	brain macrophage|brain-resident macrophage|MF.microglia.CNS|microglia|hortega cells|microgliocyte	http://purl.obolibrary.org/obo/CL_0000129		
CL:0000120	biolink:Cell	granule cell		BTO:0003393	hp.json		http://purl.obolibrary.org/obo/CL_0000120		
CL:0000121	biolink:Cell	Purkinje cell	The output neuron of the cerebellar cortex.	BTO:0001011|FMA:67969|CALOHA:TS-0845	hp.json	Purkinje neuron|cerebellum Purkinje cell|cerebellar Purkinje cell|Purkinje's cell	http://purl.obolibrary.org/obo/CL_0000121		
CL:0000123	biolink:Cell	neuron associated cell (sensu Vertebrata)			hp.json		http://purl.obolibrary.org/obo/CL_0000123		
CL:0000125	biolink:Cell	glial cell	A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.	CALOHA:TS-0415|BTO:0002606|FMA:54536	hp.json	neuroglia|neuroglial cell	http://purl.obolibrary.org/obo/CL_0000125		
CL:0000126	biolink:Cell	macroglial cell	A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together.	BTO:0000771|CALOHA:TS-2027|FMA:54538	hp.json	macrogliocyte	http://purl.obolibrary.org/obo/CL_0000126		
CHEBI:132362	biolink:ChemicalSubstance	citrate(4-)	A citrate anion obtained by deprotonation of the three carboxy groups as well as the hydroxy group of citric acid.	Chemspider:34552020	hp.json	citric acid tetraanion|2-oxido-1,2,3-propanetricarboxylate|2-oxidopropane-1,2,3-tricarboxylate	http://purl.obolibrary.org/obo/CHEBI_132362		3_STAR
GO:1904606	biolink:BiologicalProcess	fat cell apoptotic process	Any apoptotic process in a fat cell.		hp.json	adipocyte apoptotic process|adipose cell apoptotic process|adipocyte apoptosis|adipose cell apoptosis|fat cell apoptosis	http://purl.obolibrary.org/obo/GO_1904606		
CL:0000138	biolink:Cell	chondrocyte	Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell.	CALOHA:TS-0138|FMA:66782|BTO:0000249	hp.json	cartilage cell	http://purl.obolibrary.org/obo/CL_0000138		
CL:0000133	biolink:Cell	neurectodermal cell	Ectoderm destined to be nervous tissue.		hp.json	neurectoderm cell	http://purl.obolibrary.org/obo/CL_0000133		
CL:0000134	biolink:Cell	mesenchymal stem cell	A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.	BTO:0003298|FMA:70546|BTO:0002625	hp.json	colony-forming unit-fibroblast|MSC|BMSC|mesenchymal stromal cells|mesenchymal precursor cell|mesenchymal stem cell|mesenchymal stromal cell|mesenchymal progenitor cells|stem cells, mesenchymal|bone marrow stromal cells|marrow stromal cells|CFU-F	http://purl.obolibrary.org/obo/CL_0000134		
CL:0000136	biolink:Cell	fat cell	A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.	FMA:63880|CALOHA:TS-0012|BTO:0000443	hp.json	adipocyte|adipose cell	http://purl.obolibrary.org/obo/CL_0000136		
CL:0000107	biolink:Cell	autonomic neuron	A neuron whose cell body is within an autonomic ganglion.	FMA:80121	hp.json		http://purl.obolibrary.org/obo/CL_0000107		
CL:0000100	biolink:Cell	motor neuron	An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.	BTO:0000312|FMA:83617|WBbt:0005409	hp.json	motoneuron	http://purl.obolibrary.org/obo/CL_0000100		
CL:0000101	biolink:Cell	sensory neuron	Any neuron having a sensory function; an afferent neuron conveying sensory impulses.	WBbt:0005759|BTO:0001037|FMA:84649|FBbt:00005124	hp.json		http://purl.obolibrary.org/obo/CL_0000101		
GO:0015872	biolink:BiologicalProcess	dopamine transport	The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.		hp.json		http://purl.obolibrary.org/obo/GO_0015872		
GO:0015874	biolink:BiologicalProcess	norepinephrine transport	The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.		hp.json	noradrenaline transport|levarterenol transport	http://purl.obolibrary.org/obo/GO_0015874		
CL:0000103	biolink:Cell	bipolar neuron	A type of interneuron that has two neurites, usually an axon and a dendrite, extending from opposite poles of an ovoid cell body.	FMA:67282	hp.json		http://purl.obolibrary.org/obo/CL_0000103		BDS_subset
CL:0000104	biolink:Cell	multipolar neuron	A neuron with three or more neurites, usually an axon and multiple dendrites.	FMA:67287	hp.json		http://purl.obolibrary.org/obo/CL_0000104		BDS_subset
CL:0000117	biolink:Cell	CNS neuron (sensu Vertebrata)			hp.json		http://purl.obolibrary.org/obo/CL_0000117		
CL:0000118	biolink:Cell	basket cell	Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells.		hp.json		http://purl.obolibrary.org/obo/CL_0000118		BDS_subset
CL:0000119	biolink:Cell	cerebellar Golgi cell	Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004.		hp.json	Golgi cell|cerebellum Golgi cell|cerebellar Golgi neuron|Golgi neuron	http://purl.obolibrary.org/obo/CL_0000119		
CL:0000111	biolink:Cell	peripheral neuron	A neuron that is part of nerve found outside the central nervous system.	FMA:84664	hp.json		http://purl.obolibrary.org/obo/CL_0000111		
CL:0000114	biolink:Cell	surface ectodermal cell		FMA:72552	hp.json	cell of surface ectoderm|surface ectoderm cell	http://purl.obolibrary.org/obo/CL_0000114		
CL:0000115	biolink:Cell	endothelial cell	An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.	FMA:66772|BTO:0001176|CALOHA:TS-0278	hp.json	endotheliocyte	http://purl.obolibrary.org/obo/CL_0000115		
UBERON:0000935	biolink:AnatomicalEntity	anterior commissure	A bundle of myelinated nerve fibers passing transversely through the lamina terminalis and connecting symmetrical parts of the two cerebral hemispheres; it consists of a smaller anterior part (pars anterior commissurae anterioris) and a larger posterior part (pars posterior commissurae anterioris).	ZFA:0001108|BM:Tel-AC|DHBA:10559|UMLS:C0152335|TAO:0001108|NLX:144088|MA:0002722|EMAPA:19038|BAMS:AG|HBA:9221|UMLS:C0152335|DMBA:17751|FMA:61961|BAMS:Ac|BAMS:AC|VHOG:0001558|BAMS:ac|NCIT:C32086|BTO:0002169|BIRNLEX:1557	hp.json	commissura rostral|precommisure|commissura anterior|commissura rostralis|rostral commissure|commissura anterior cerebri|anterior cerebral commissure|anterior commissural nucleus|AC|paleocortical commissure	http://purl.obolibrary.org/obo/UBERON_0000935		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas
UBERON:0000930	biolink:AnatomicalEntity	stomodeum	Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity.	XAO:0000269|TGMA:0000135|TAO:0001290|NCIT:C34306|FMA:295846|EMAPA:16263|FBbt:00000439|UMLS:C1514977|EHDAA2:0001929|Wikipedia:Stomodeum|ZFA:0001290|BTO:0004224	hp.json	primitive oral cavity|stomatodeum|stomodaeum|mouth primordium|stomodeal-hypophyseal primordium|oral pit|oral ectoderm|primitive oral cavity|mouth pit|stomatodeum	http://purl.obolibrary.org/obo/UBERON_0000930		uberon_slim|vertebrate_core|grouping_class|pheno_slim
UBERON:0000931	biolink:AnatomicalEntity	proctodeum	Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract.	FBbt:00000123|Wikipedia:Proctodeum|ZFA:0000066|NCIT:C34278|UMLS:C0231054|TAO:0000066|VHOG:0000139|EHDAA2:0000121|AAO:0011087|XAO:0001019|EMAPA:25038	hp.json	proctodaeum|amnioproctodeal invagination|embryonic proctodaeum|anal pit|anus porus	http://purl.obolibrary.org/obo/UBERON_0000931		uberon_slim
UBERON:0000933	biolink:AnatomicalEntity	pharyngeal muscle	A muscle that acts on the pharynx[WP, vetted].	EMAPA:18963|MA:0001797|FMA:46619|GAID:154|UMLS:C0031346|EFO:0003504|MESH:D010609|ZFA:0000172|BTO:0001048|TAO:0000172|NCIT:C13075	hp.json	branchial muscles|muscle of pharynx|muscle organ of pharynx|tunica muscularis pharyngis|branchial muscle|pharynx muscle organ|musculus pharyngis|pharynx muscle|musculi pharyngis	http://purl.obolibrary.org/obo/UBERON_0000933		pheno_slim|efo_slim
GO:0015850	biolink:BiologicalProcess	organic hydroxy compound transport	The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.		hp.json	organic alcohol transport	http://purl.obolibrary.org/obo/GO_0015850		
GO:0015851	biolink:BiologicalProcess	nucleobase transport	The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	nucleobase transmembrane transport	http://purl.obolibrary.org/obo/GO_0015851		
CHEBI:50177	biolink:ChemicalSubstance	dermatologic drug	A drug used to treat or prevent skin disorders or for the routine care of skin.		hp.json	dermatologic agent|dermatologic drugs|dermatological agent	http://purl.obolibrary.org/obo/CHEBI_50177		3_STAR
UBERON:0000923	biolink:AnatomicalEntity	germ layer	A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm.	BILA:0000035|UMLS:C1708239|VHOG:0001223|AAO:0000480|FMA:69069|NCIT:C54105|Wikipedia:Germ_layer|EMAPA:36033|FBbt:00000110|ZFA:0001122|GAID:1303|MESH:D005855|UMLS:C0920502|NCIT:C12950|XAO:0003011|BTO:0000556|TAO:0001122	hp.json	primary germ layer|embryonic tissue|embryonic germ layers|germinal layer|embryonic germ layer	http://purl.obolibrary.org/obo/UBERON_0000923		uberon_slim|vertebrate_core
UBERON:0000924	biolink:AnatomicalEntity	ectoderm	Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.	MESH:D004475|CALOHA:TS-0216|BILA:0000036|MAT:0000173|EHDAA2:0000428|NCIT:C12703|ZFA:0000016|UMLS:C0013574|MIAA:0000173|VHOG:0000153|EMAPA:16069|FBbt:00000111|XAO:0000001|TAO:0000016|EFO:0000414|GAID:1304|AAO:0000137|BTO:0000315|EV:0100003|Wikipedia:Ectoderm|SCTID:362851007|MAT:0000155|FMA:69070	hp.json	embryonic ectoderm	http://purl.obolibrary.org/obo/UBERON_0000924		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0000925	biolink:AnatomicalEntity	endoderm	Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.	MAT:0000175|Wikipedia:Endoderm|NCIT:C12706|XAO:0000090|UMLS:C0014144|MESH:D004707|ZFA:0000017|MIAA:0000175|VHOG:0000154|FBbt:00000125|SCTID:362855003|EHDAA2:0000436|TAO:0000017|GAID:1305|AAO:0000139|CALOHA:TS-0273|EV:0100005|BTO:0000800|EFO:0002545|EMAPA:16062|FMA:69071|BILA:0000038	hp.json	entoderm|entoderm	http://purl.obolibrary.org/obo/UBERON_0000925		efo_slim|uberon_slim|vertebrate_core|pheno_slim
UBERON:0000926	biolink:AnatomicalEntity	mesoderm	The middle germ layer of the embryo, between the endoderm and ectoderm.	EMAPA:16083|BILA:0000037|CALOHA:TS-0623|TAO:0000041|EFO:0001981|MAT:0000174|EHDAA:183|UMLS:C0025485|Wikipedia:Mesoderm|EHDAA:160|SCTID:362854004|BTO:0000839|FBbt:00000126|MIAA:0000174|GAID:522|VHOG:0000152|EHDAA2:0001128|EV:0100006|AAO:0000304|EHDAA:124|MESH:D008648|ZFA:0000041|NCIT:C12750|FMA:69072|XAO:0000050	hp.json	entire mesoderm|embryonic mesoderm|mesodermal mantle|entire mesoderm	http://purl.obolibrary.org/obo/UBERON_0000926		efo_slim|uberon_slim|vertebrate_core|pheno_slim
UBERON:0000922	biolink:AnatomicalEntity	embryo	Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.	EHDAA2_RETIRED:0003236|BILA:0000056|OpenCyc:Mx4rwP1ceZwpEbGdrcN5Y29ycA|GAID:963|EMAPA:16039|Wikipedia:Embryo|UMLS:C0013935|ZFA:0000103|FMA:69068|XAO:0000113|EHDAA:38|SCTID:57991002|MAT:0000226|BSA:0000039|OGEM:000001|MIAA:0000019|MESH:D004622|FBbt:00000052|EHDAA2:0000002|BTO:0000379|EFO:0001367|http://neurolex.org/wiki/Category:Embryonic_organism|CALOHA:TS-0229|AAO:0011035|VHOG:0001766|NCIT:C28147|AEO:0000169	hp.json	developmental tissue|developing organism|embryonic organism	http://purl.obolibrary.org/obo/UBERON_0000922		uberon_slim|vertebrate_core|pheno_slim|efo_slim
GO:1904649	biolink:BiologicalProcess	regulation of fat cell apoptotic process	Any process that modulates the frequency, rate or extent of fat cell apoptotic process.		hp.json	regulation of adipose cell apoptosis|regulation of fat cell apoptosis|regulation of adipocyte apoptosis|regulation of adipose cell apoptotic process|regulation of adipocyte apoptotic process	http://purl.obolibrary.org/obo/GO_1904649		
UBERON:0000929	biolink:AnatomicalEntity	pharyngeal branch of vagus nerve	Motor nerve of the pharynx, arises from the upper part of the ganglion nodosum, and consists principally of filaments from the cranial portion of the accessory nerve.	FMA:6234	hp.json	ramus pharyngeus|vagal pharyngeal branch|vagus nerve pharyngeal branch|ramus pharyngeus|tenth cranial nerve pharyngeal branch|pharyngeal branch|ramus pharyngeus nervi vagi|pharyngeal branch of vagus|pharyngeal branch of inferior vagal ganglion|ramus pharyngealis nervi vagalis	http://purl.obolibrary.org/obo/UBERON_0000929		uberon_slim
GO:1904651	biolink:BiologicalProcess	positive regulation of fat cell apoptotic process	Any process that activates or increases the frequency, rate or extent of fat cell apoptotic process.		hp.json	up regulation of fat cell apoptotic process|up-regulation of adipose cell apoptotic process|activation of adipose cell apoptotic process|activation of adipose cell apoptosis|up-regulation of fat cell apoptotic process|upregulation of adipose cell apoptosis|upregulation of adipocyte apoptotic process|activation of fat cell apoptosis|activation of fat cell apoptotic process|upregulation of fat cell apoptosis|up-regulation of adipocyte apoptosis|positive regulation of adipose cell apoptosis|up regulation of adipocyte apoptosis|upregulation of adipose cell apoptotic process|positive regulation of fat cell apoptosis|up regulation of adipose cell apoptosis|upregulation of fat cell apoptotic process|up-regulation of adipocyte apoptotic process|positive regulation of adipocyte apoptosis|up regulation of fat cell apoptosis|positive regulation of adipose cell apoptotic process|up-regulation of adipose cell apoptosis|up regulation of adipocyte apoptotic process|up-regulation of fat cell apoptosis|up regulation of adipose cell apoptotic process|upregulation of adipocyte apoptosis|positive regulation of adipocyte apoptotic process|activation of adipocyte apoptotic process|activation of adipocyte apoptosis	http://purl.obolibrary.org/obo/GO_1904651		
GO:1904650	biolink:BiologicalProcess	negative regulation of fat cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of fat cell apoptotic process.		hp.json	down regulation of adipocyte apoptosis|down regulation of fat cell apoptosis|downregulation of adipose cell apoptotic process|down-regulation of adipose cell apoptosis|negative regulation of adipose cell apoptosis|downregulation of fat cell apoptotic process|down-regulation of adipocyte apoptotic process|negative regulation of adipocyte apoptotic process|down-regulation of fat cell apoptosis|downregulation of adipocyte apoptosis|negative regulation of fat cell apoptosis|down regulation of adipose cell apoptotic process|down regulation of adipocyte apoptotic process|inhibition of adipose cell apoptotic process|inhibition of adipose cell apoptosis|down regulation of fat cell apoptotic process|down-regulation of adipose cell apoptotic process|inhibition of fat cell apoptosis|negative regulation of adipose cell apoptotic process|inhibition of fat cell apoptotic process|inhibition of adipocyte apoptotic process|inhibition of adipocyte apoptosis|down-regulation of fat cell apoptotic process|downregulation of adipocyte apoptotic process|downregulation of adipose cell apoptosis|down-regulation of adipocyte apoptosis|downregulation of fat cell apoptosis|negative regulation of adipocyte apoptosis|down regulation of adipose cell apoptosis	http://purl.obolibrary.org/obo/GO_1904650		
CHEBI:50160	biolink:ChemicalSubstance	steroid acid anion	Any anion formed by loss of a proton from a steroid acid.		hp.json	steroid acid anions	http://purl.obolibrary.org/obo/CHEBI_50160		3_STAR
UBERON:0000912	biolink:AnatomicalEntity	mucus	Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water.	Wikipedia:Mucus|ENVO:02000040|OpenCyc:Mx4rvVjHq5wpEbGdrcN5Y29ycA|GAID:1164|FMA:66938|CALOHA:TS-2144|UMLS:C0026727|NCIT:C13259|galen:Mucus|MESH:D009093	hp.json		http://purl.obolibrary.org/obo/UBERON_0000912		
UBERON:0000913	biolink:AnatomicalEntity	interstitial fluid	Interstitial fluid is a bodily fluid consisting of a solution which bathes and surrounds the cells of multicellular animals. It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid.	FMA:9673|NCIT:C120839|ENVO:02000042	hp.json	intercellular fluid|tissue fluid	http://purl.obolibrary.org/obo/UBERON_0000913		pheno_slim
UBERON:0000915	biolink:AnatomicalEntity	thoracic segment of trunk	Subdivision of trunk that lies between the head and the abdomen.	FMA:259209|EMAPA:35862|Wikipedia:Thorax|SCTID:302551006|MA:0000022	hp.json	thorax|anterior subdivision of trunk|upper trunk|upper body	http://purl.obolibrary.org/obo/UBERON_0000915		uberon_slim
GO:1904659	biolink:BiologicalProcess	glucose transmembrane transport	The process in which glucose is transported across a membrane.		hp.json	glucose transport	http://purl.obolibrary.org/obo/GO_1904659		
UBERON:0000916	biolink:AnatomicalEntity	abdomen	The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column.	Wikipedia:Abdomen|MAT:0000298|EV:0100011|MIAA:0000298|MA:0000029|EMAPA:35102|BTO:0000020|OpenCyc:Mx4rvVjgyZwpEbGdrcN5Y29ycA|SCTID:302553009|EFO:0000968|CALOHA:TS-0001|MESH:D000005|FMA:9577|galen:Abdomen|GAID:16	hp.json	abdominopelvis|abdominopelvic region|belly|adult abdomen|celiac region	http://purl.obolibrary.org/obo/UBERON_0000916		pheno_slim|efo_slim|uberon_slim
CHEBI:49167	biolink:ChemicalSubstance	anti-asthmatic drug	A drug used to treat asthma.		hp.json	anti-asthmatic drugs|anti-asthmatic agents|anti-asthmatic agent	http://purl.obolibrary.org/obo/CHEBI_49167		3_STAR
GO:0015837	biolink:BiologicalProcess	amine transport	The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	amine/polyamine transport	http://purl.obolibrary.org/obo/GO_0015837		goslim_pir
GO:0015833	biolink:BiologicalProcess	peptide transport	The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0015833		goslim_pir
GO:0062237	biolink:BiologicalProcess	protein localization to postsynapse	Any process in which a protein is transported to, and/or maintained at the postsynapse, the part of a synapse that is part of the post-synaptic cell.		hp.json		http://purl.obolibrary.org/obo/GO_0062237		
CHEBI:37175	biolink:ChemicalSubstance	organic hydride			hp.json	organic hydrides	http://purl.obolibrary.org/obo/CHEBI_37175		3_STAR
GO:0003857	biolink:MolecularActivity	3-hydroxyacyl-CoA dehydrogenase activity	Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+).	Reactome:R-HSA-508369|Reactome:R-HSA-77342|EC:1.1.1.35|Reactome:R-HSA-77254|Reactome:R-HSA-193455|Reactome:R-HSA-390251|Reactome:R-HSA-389995|Reactome:R-HSA-193508|Reactome:R-HSA-77312|Reactome:R-HSA-77303|RHEA:22432|Reactome:R-HSA-77331|UM-BBD_enzymeID:e0664|Reactome:R-HSA-70837|Reactome:R-HSA-77283|MetaCyc:OHACYL-COA-DEHYDROG-RXN|Reactome:R-HSA-6809264|Reactome:R-HSA-77323	hp.json	beta-hydroxybutyrylcoenzyme A dehydrogenase activity|3-oxoacyl-thioester reductase activity|L-3-hydroxyacyl CoA dehydrogenase activity|beta-keto-reductase activity|L-3-hydroxyacyl coenzyme A dehydrogenase activity|beta-hydroxyacyl-coenzyme A synthetase activity|beta-ketoacyl-CoA reductase|beta-hydroxyacylcoenzyme A dehydrogenase activity|beta-hydroxyacyl dehydrogenase activity	http://purl.obolibrary.org/obo/GO_0003857		
CHEBI:37176	biolink:ChemicalSubstance	mononuclear parent hydride			hp.json	mononuclear hydrides|mononuclear parent hydrides|mononuclear hydride	http://purl.obolibrary.org/obo/CHEBI_37176		3_STAR
GO:0015849	biolink:BiologicalProcess	organic acid transport	The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0015849		goslim_pir
GO:0015844	biolink:BiologicalProcess	monoamine transport	The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0015844		
HP:0034371	biolink:PhenotypicFeature	Reduced circulating prekallikrein concentration	Reduced concentration of prekallikrein (PK; also known as Fletcher factor) in the blood circulation. PK is the precursor of plasma kallikrein, a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII.		hp.json		http://purl.obolibrary.org/obo/HP_0034371		
HP:0034370	biolink:PhenotypicFeature	Abnormal muscle tissue metabolite concentration			hp.json		http://purl.obolibrary.org/obo/HP_0034370		
HP:0034373	biolink:PhenotypicFeature	External tibial torsion	External twisting of the tibia resulting in the toes of each foot pointing outward (outtoeing) .		hp.json	External tibial rotation	http://purl.obolibrary.org/obo/HP_0034373		
HP:0034372	biolink:PhenotypicFeature	Internal tibial torsion			hp.json	Internal tibial rotation	http://purl.obolibrary.org/obo/HP_0034372		
HP:0034379	biolink:PhenotypicFeature	Vascular granular osmiophilic material deposition	Accumulation of granular osmiophilic material in blood vessel walls. Osmiophilic material becomes black upon staining with osmium tetroxide.		hp.json		http://purl.obolibrary.org/obo/HP_0034379		
HP:0034378	biolink:PhenotypicFeature	Urethrovesical occlusion	Blockage of the flow of urine from the bladder into the urethra.		hp.json		http://purl.obolibrary.org/obo/HP_0034378		
HP:0034375	biolink:PhenotypicFeature	Spherophakia	Spherophakia is a rare congenital condition that presents with weak zonules around a smaller and more spherical crystalline lens with an increased anteroposterior thickness of the lens, and highly myopic eye. The lens zonules are developmentally hypoplastic and abnormally weak and due to non-attachment of the posterior zonules to the equatorial zone of the lens, the lens changes its normal shape to spherical.		hp.json		http://purl.obolibrary.org/obo/HP_0034375		
HP:0034374	biolink:PhenotypicFeature	Trident acetabulum	Abnormal appearance of the acetabulum characterized by spurs at the medial and lateral acetabular margin and in the center of the acetabulum, giving rise to shape resembling a three-pronged spear sadi to resemble a trident.		hp.json	Trident acetabula	http://purl.obolibrary.org/obo/HP_0034374		
HP:0034377	biolink:PhenotypicFeature	Single atrioventricular valve regurgitation	Regurgitation of the single atrioventricular valve regurgitation (AVVR) in the context of a congenital heart defect with a single ventricle. Roughly three quarters of patients following Fontan procedure display AVVR.		hp.json		http://purl.obolibrary.org/obo/HP_0034377		
HP:0034376	biolink:PhenotypicFeature	Atrioventricular valve regurgitation	Regurgitation of a heart valve that controls blood flow from a an atrium to a ventricle, including mitral, tricuspid, or, rarely, single atrioventicular valve.		hp.json		http://purl.obolibrary.org/obo/HP_0034376		
CHEBI:15801	biolink:ChemicalSubstance	(R)-2-hydroxyglutarate(2-)	A 2-hydroxyglutarate(2-) that has (2R)-configuration.	KEGG:C01087|MetaCyc:R-2-HYDROXYGLUTARATE	hp.json	(R)-2-hydroxyglutarate|(R)-2-hydroxyglutarate|(2R)-2-hydroxypentanedioate	http://purl.obolibrary.org/obo/CHEBI_15801		3_STAR
GO:2001035	biolink:BiologicalProcess	regulation of tongue muscle cell differentiation	Any process that modulates the frequency, rate or extent of tongue muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2001035		
GO:2001036	biolink:BiologicalProcess	negative regulation of tongue muscle cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of tongue muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2001036		
GO:2001037	biolink:BiologicalProcess	positive regulation of tongue muscle cell differentiation	Any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2001037		
CHEBI:76760	biolink:ChemicalSubstance	EC 3.1.* (ester hydrolase) inhibitor	A hydrolase inhibitor that interferes with the action of any ester hydrolase (EC 3.1.*.*).		hp.json	ester hydrolase inhibitor|EC 3.1.* (ester hydrolase) inhibitors|ester hydrolase (EC 3.1.*) inhibitors|ester hydrolase (EC 3.1.*) inhibitor|ester hydrolase inhibitors|EC 3.1.* inhibitor|EC 3.1.* inhibitors	http://purl.obolibrary.org/obo/CHEBI_76760		3_STAR
CHEBI:76761	biolink:ChemicalSubstance	EC 3.2.* (glycosylase) inhibitor	A hydrolase inhibitor that interferes with the action of any glycosylase (EC 3.2.*.*).		hp.json	glycosylase inhibitor|glycosylase (EC 3.2.*) inhibitors|EC 3.2.* (glycosylase) inhibitors|glycosylase (EC 3.2.*) inhibitor|glycosylase inhibitors|EC 3.2.* inhibitor|EC 3.2.* inhibitors	http://purl.obolibrary.org/obo/CHEBI_76761		3_STAR
PR:P04275	biolink:Protein	von Willebrand factor (human)	A von Willebrand factor that is encoded in the genome of human.	UniProtKB:P04275	hp.json	vWF (human)|hVWF|VWF|F8VWF	http://purl.obolibrary.org/obo/PR_P04275		
CHEBI:76764	biolink:ChemicalSubstance	EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor	Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*).		hp.json	EC 3.5.* inhibitors|EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitors|EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitor|EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors|EC 3.5.* (hydrolase acting on non-peptide C-N bond) inhibitor|EC 3.5.* inhibitor|EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitors	http://purl.obolibrary.org/obo/CHEBI_76764		3_STAR
HP:0034382	biolink:PhenotypicFeature	Disease remission	A decrease in or disappearance of signs and symptoms typically associated with a disease course.		hp.json		http://purl.obolibrary.org/obo/HP_0034382		
HP:0010393	biolink:PhenotypicFeature	Abnormality of the middle phalanx of the 5th toe		UMLS:C4023861	hp.json	Abnormality of the middle bone of the little toe|Abnormality of the middle bone of the pinkie toe|Abnormality of the middle bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0010393		
HP:0034381	biolink:PhenotypicFeature	Central nervous system axonal spheroid	Axonal spheroids are bubble-like biological features that form on most degenerating axons. During neurodegeneration, bubble-like swellings form along the length of the axon, a primary and early effect of dynamic axonal deformation. These varicosities, spheroids, or swellings have been described as beads on a string and branches bearing fruit, and they frequently appear on degenerating axons. The focal swellings on degenerating axons, axonal spheroids, are often filled with cellular debris such as organelles, pathological proteins, and disorganized cytoskeletal elements.		hp.json	CNS axonal spheroid	http://purl.obolibrary.org/obo/HP_0034381		
HP:0010392	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the 5th toe		UMLS:C4023862	hp.json	Abnormality of the outermost bone of the little toe|Abnormality of the outermost bone of the pinkie toe|Abnormality of the outermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0010392		
HP:0010391	biolink:PhenotypicFeature	Duplication of the phalanges of the 5th toe	Partial or complete duplication of one or more phalanx of little toe.	UMLS:C4020903	hp.json	Duplication of the bones of the pinkie toe|Duplication of the bones of the pinky toe|Partial/complete duplication of the phalanges of the 5th toe|Duplication of the bones of the little toe|Duplication of the phalanges of the fifth toe	http://purl.obolibrary.org/obo/HP_0010391		
HP:0034384	biolink:PhenotypicFeature	Elevated circulating insulin:C-peptide ratio	Increased ratio of insulin to C-peptide in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034384		
HP:0010390	biolink:PhenotypicFeature	Triangular shaped phalanges of the 5th toe		UMLS:C4023863	hp.json	Triangular shaped little toe bone|Triangular shaped pinky toe bone|Triangular shaped pinkie toe bone	http://purl.obolibrary.org/obo/HP_0010390		
HP:0034383	biolink:PhenotypicFeature	Elevated circulating biliverdin concentration	Increased concentration of biliverdin, a green tetrapyrrolic bile pigment, in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034383		
HP:0034380	biolink:PhenotypicFeature	Juvenile type testicular granulosa cell tumor	Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia.		hp.json		http://purl.obolibrary.org/obo/HP_0034380		
HP:0034389	biolink:PhenotypicFeature	Pulmonary vein varix	Pulmonary vein varix (PVV), refers to a localised dilatation of a pulmonary vein. PVV is a rare condition and can be congenital or acquired. PVV typically occur at the confluence of the veins adjacent to the left atrium. PVVs are sometimes classified into three morphological types: saccular, tortuous and confluent.		hp.json	Pulmonary vein dilatation	http://purl.obolibrary.org/obo/HP_0034389		
HP:0010399	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanx of the 2nd toe		UMLS:C4023855	hp.json		http://purl.obolibrary.org/obo/HP_0010399		
HP:0010398	biolink:PhenotypicFeature	Curved proximal phalanx of the 2nd toe	A deviation from the normal straight form of the proximal phalanx of the 2nd toe.	UMLS:C4023856	hp.json	Curved innermost bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010398		
HP:0010397	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the 2nd toe	An abnormal morphology of the proximal phalanx of the 2nd toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4023857	hp.json	Bullet-shaped innermost bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010397		
HP:0034386	biolink:PhenotypicFeature	Reduced left ventricular endsystolic diameter	A lower than normal left ventricular endsystolic diameter.		hp.json		http://purl.obolibrary.org/obo/HP_0034386		
HP:0010396	biolink:PhenotypicFeature	Broad proximal phalanx of the 2nd toe		UMLS:C4023858	hp.json	Broad innermost bone of 2nd toe	http://purl.obolibrary.org/obo/HP_0010396		
HP:0034385	biolink:PhenotypicFeature	Abnormal left ventricular endsystolic diameter	A deviation from the normal range of the left ventricular endsystolic diameter.		hp.json		http://purl.obolibrary.org/obo/HP_0034385		
HP:0010395	biolink:PhenotypicFeature	Aplasia/hypoplasia of the proximal phalanx of the 2nd toe	Absence (agenesis) or underdevelopment of the proximal phalanx of the 2nd toe.	UMLS:C4023859	hp.json	Absent/underdeveloped innermost 2nd toe bone|Absent/small innermost 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010395		
HP:0034388	biolink:PhenotypicFeature	Hilar lymph node enlargement	Hilar lymphadenopathy is swelling or enlargement of lymph nodes localised in hila, wedge-shaped anatomical structures containing pulmonary vessels, major bronchi, nerves and lymph nodes. Hilar lymph nodes are not visible on chest X-ray if they are not enlarged. Hilar lymph node enlargement can be caused by benign and malignant conditions and can be symmetrical (bilateral) or asymmetrical (unilateral).		hp.json	Hilar lymphadenopathy	http://purl.obolibrary.org/obo/HP_0034388		
HP:0034387	biolink:PhenotypicFeature	Bacterial encephalitis	Encephalitis caused by bacterial infection.		hp.json		http://purl.obolibrary.org/obo/HP_0034387		
HP:0010394	biolink:PhenotypicFeature	Abnormal morphology of the proximal phalanx of the 5th toe		UMLS:C4023860	hp.json	Abnormality of the innermost bone of the little toe|Abnormality of the innermost bone of the pinkie toe|Abnormality of the innermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0010394		
CHEBI:76773	biolink:ChemicalSubstance	EC 3.1.1.* (carboxylic ester hydrolase) inhibitor	An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a carboxylic ester hydrolase (EC 3.1.1.*).		hp.json	EC 3.1.1.* inhibitors|EC 3.1.1.* inhibitor|carboxylic ester hydrolase (EC 3.1.1.*) inhibitor|EC 3.1.1.* (carboxylic ester hydrolase) inhibitors|carboxylic ester hydrolase (EC 3.1.1.*) inhibitors	http://purl.obolibrary.org/obo/CHEBI_76773		3_STAR
HP:0034393	biolink:PhenotypicFeature	Elbow extension contracture	An elbow contracture that limits the ability of the elbow joint to flex (flexion of the the elbow joint refers to bending the elbow joint to bring the hand closer to the shoulder), meaning that the elbow is fixed in an extended (straight) position.		hp.json		http://purl.obolibrary.org/obo/HP_0034393		
HP:0009393	biolink:PhenotypicFeature	Absent epiphyses of the 4th finger	Absence of one or more epiphyses of the 4th finger.	UMLS:C4024397	hp.json	Absent end part of the ring finger bone	http://purl.obolibrary.org/obo/HP_0009393		
HP:0010382	biolink:PhenotypicFeature	Abnormal morphology of the proximal phalanx of the 4th toe		UMLS:C4023868	hp.json	Abnormal innermost 4th toe bone	http://purl.obolibrary.org/obo/HP_0010382		
HP:0009392	biolink:PhenotypicFeature	Triangular epiphyses of the 5th finger	A triangular appearance of the epiphyses of the 5th finger of the hand.	UMLS:C4021483	hp.json	Delta-shaped epiphyses of the 5th finger|Triangular end part of the pinky finger|Triangular end part of the pinkie finger|Triangular end part of the little finger	http://purl.obolibrary.org/obo/HP_0009392		
HP:0034392	biolink:PhenotypicFeature	Joint contracture	A limitation in the passive range of motion of the elbow resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin. A contracture prevents movement of the associated body part.		hp.json	Contracture	http://purl.obolibrary.org/obo/HP_0034392		
HP:0010381	biolink:PhenotypicFeature	Abnormality of the middle phalanx of the 4th toe		UMLS:C4023869	hp.json	Abnormality of middle 4th toe bone	http://purl.obolibrary.org/obo/HP_0010381		
HP:0009395	biolink:PhenotypicFeature	Cone-shaped epiphyses of the 4th finger	A cone-shaped appearance of the epiphyses of the 4th finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.	UMLS:C4024395	hp.json	Cone-shaped end part of the ring finger bones	http://purl.obolibrary.org/obo/HP_0009395		
HP:0034395	biolink:PhenotypicFeature	Forearm pronation contracture	A contracture that limits the ability of the forearm to stabilize the hand in supiation (supination refers to a rotation of the forearm that causes the palm and forearm to face upwards), meaning that the palm is fixed in a downward orientation. Restriction of supination/pronation can occur at the elbow (radial-humeral joint), at the wrist (radial-ulnar joint), and anywhere in between.		hp.json	Pronation contracture of the forearm	http://purl.obolibrary.org/obo/HP_0034395		
HP:0010380	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the 4th toe		UMLS:C4023870	hp.json	Abnormality of the outermost 4th toe bone	http://purl.obolibrary.org/obo/HP_0010380		
HP:0034394	biolink:PhenotypicFeature	Forearm supination contracture	A contracture that limits the ability of the forearm to stabilize the hand in pronation (pronation refers to a rotation of the forearm that causes the palm and forearm to face downwards), meaning that the palm is fixed in a upward orientation. Restriction of supination/pronation can occur at the elbow (radial-humeral joint), at the wrist (radial-ulnar joint), and anywhere in between.		hp.json	Supination contracture of the forearm	http://purl.obolibrary.org/obo/HP_0034394		
HP:0009394	biolink:PhenotypicFeature	Bracket epiphyses of the 4th finger	An abnormality of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024396	hp.json	Bracket shaped end part of ring finger bones	http://purl.obolibrary.org/obo/HP_0009394		
HP:0009391	biolink:PhenotypicFeature	Stippling of the epiphyses of the 5th finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 5th finger.	UMLS:C4024398	hp.json	Speckled calcifications in end part of pinky finger bone|Speckled calcifications in end part of little finger bone|Speckled calcifications in end part of pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009391		
HP:0034391	biolink:PhenotypicFeature	Elbow contracture	A limitation in the passive range of motion of the elbow resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin.		hp.json		http://purl.obolibrary.org/obo/HP_0034391		
HP:0034390	biolink:PhenotypicFeature	Decreased CSF glycine concentration	Abnormally decreased levels of glycine in cerebrospinal fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0034390		
HP:0009390	biolink:PhenotypicFeature	Small epiphyses of the 5th finger	Abnormally small size of the epiphyses of the 5th finger with respect to age-dependent norms.	UMLS:C4024399	hp.json	Small end part of pinky finger bone|Small end part of little finger bone|Small end part of pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009390		
HP:0010389	biolink:PhenotypicFeature	Symphalangism affecting the phalanges of the 5th toe		UMLS:C4023864	hp.json	Fused bones in the pinky toe|Fused bones in the little toe|Fused bones in the pinkie toe	http://purl.obolibrary.org/obo/HP_0010389		
HP:0010388	biolink:PhenotypicFeature	Patchy sclerosis of 5th toe phalanx	Patchy (irregular) increase in bone density of one or more of the phalanges of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4021275	hp.json	Uneven increase in bone density in little toe bone|Patchy sclerosis of the phalanges of the 5th toe|Uneven increase in bone density in pinky toe bone|Uneven increase in bone density in pinkie toe bone	http://purl.obolibrary.org/obo/HP_0010388		
HP:0010387	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the 5th toe		UMLS:C4023865	hp.json		http://purl.obolibrary.org/obo/HP_0010387		
HP:0010386	biolink:PhenotypicFeature	Curved 5th toe phalanx	A deviation from the normal straight form of one or more phalanges of the fifth toe.	UMLS:C4021276	hp.json	Curved pinkie toe bones|Curved pinky toe bones|Curved little toe bones|Curved phalanges of the 5th toe	http://purl.obolibrary.org/obo/HP_0010386		
HP:0010385	biolink:PhenotypicFeature	Bullet-shaped 5th toe phalanx	An abnormal morphology of one or more phalanges of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021277	hp.json	Bullet-shaped bones of the pinkie toe|Bullet-shaped phalanges of the 5th toe|Bullet-shaped bones of the pinky toe|Bullet-shaped bones of the little toe	http://purl.obolibrary.org/obo/HP_0010385		
HP:0010384	biolink:PhenotypicFeature	Broad phalanges of the 5th toe		UMLS:C4023866	hp.json	Broad bones of the little toe|Broad bones of the pinkie toe|Broad bones of the pinky toe	http://purl.obolibrary.org/obo/HP_0010384		
HP:0010383	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the 5th toe		UMLS:C4023867	hp.json	Absent/small little toe bones|Absent/small pinky toe bones|Absent/small pinkie toe bones|Absent/underdeveloped pinky toe bones	http://purl.obolibrary.org/obo/HP_0010383		
GO:2001053	biolink:BiologicalProcess	regulation of mesenchymal cell apoptotic process	Any process that modulates the frequency, rate or extent of mesenchymal cell apoptotic process.		hp.json	regulation of mesenchymal cell apoptosis	http://purl.obolibrary.org/obo/GO_2001053		
GO:2001054	biolink:BiologicalProcess	negative regulation of mesenchymal cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of mesenchymal cell apoptotic process.		hp.json	negative regulation of mesenchymal cell apoptosis	http://purl.obolibrary.org/obo/GO_2001054		
CL:0000187	biolink:Cell	muscle cell	A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.	BTO:0000888|CALOHA:TS-2032|FMA:67328|WBbt:0003675|FBbt:00005074|BTO:0000902	hp.json	muscle fiber|myocyte	http://purl.obolibrary.org/obo/CL_0000187		
GO:2001055	biolink:BiologicalProcess	positive regulation of mesenchymal cell apoptotic process	Any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process.		hp.json	positive regulation of mesenchymal cell apoptosis	http://purl.obolibrary.org/obo/GO_2001055		
CL:0000188	biolink:Cell	cell of skeletal muscle	A somatic cell located in skeletal muscle.	BTO:0004392|FMA:9727|CALOHA:TS-2158	hp.json	skeletal muscle cell	http://purl.obolibrary.org/obo/CL_0000188		
HP:0009389	biolink:PhenotypicFeature	Pseudoepiphyses of the 5th finger	A secondary ossification center in the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024400	hp.json		http://purl.obolibrary.org/obo/HP_0009389		
HP:0009386	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the 5th finger	Fragmented appearance of the epiphyses of the 5th finger.	UMLS:C4024403	hp.json	Fragmentation of the end part of the pinkie finger bones|Fragmentation of the end part of the little finger bones|Fragmentation of the end part of the pinky finger bones	http://purl.obolibrary.org/obo/HP_0009386		
HP:0009385	biolink:PhenotypicFeature	Enlarged epiphyses of the 5th finger	Abnormally large size of the epiphyses of the 5th finger with respect to age-dependent norms.	UMLS:C4024404	hp.json	Enlarged end part of the pinkie finger bones|Enlarged end part of the little finger bones|Enlarged end part of the pinky finger bones	http://purl.obolibrary.org/obo/HP_0009385		
CL:0000182	biolink:Cell	hepatocyte	The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.	BTO:0000575|FMA:14515|CALOHA:TS-0454	hp.json		http://purl.obolibrary.org/obo/CL_0000182		
CL:0000183	biolink:Cell	contractile cell	A cell whose primary function is to shorten.		hp.json		http://purl.obolibrary.org/obo/CL_0000183		
HP:0009388	biolink:PhenotypicFeature	Ivory epiphyses of the 5th finger	Sclerosis of the epiphyses of the 5th finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024401	hp.json	Increased bone density of end part of the pinky finger|Increased bone density of end part of the pinkie finger|Increased bone density of end part of the little finger	http://purl.obolibrary.org/obo/HP_0009388		
HP:0009387	biolink:PhenotypicFeature	Irregular epiphyses of the 5th finger	Irregular radiographic opacity of the epiphyses of the 5th finger.	UMLS:C4024402	hp.json	Irregular end part of the pinkie finger bones|Irregular end part of the little finger bones|Irregular end part of the pinky finger bones	http://purl.obolibrary.org/obo/HP_0009387		
HP:0010371	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the 4th toe		UMLS:C4023875	hp.json	Absent/underdeveloped bones of 4th toe|Absent/small bones of 4th toe	http://purl.obolibrary.org/obo/HP_0010371		
HP:0010370	biolink:PhenotypicFeature	Abnormal morphology of the proximal phalanx of the 3rd toe	An anomaly of the proximal phalanx of third toe.	UMLS:C4023876	hp.json	Abnormality of the innermost bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0010370		
HP:0010379	biolink:PhenotypicFeature	Duplication of phalanx of the 4th toe	Partial or complete duplication of phalanx of fourth toe.	UMLS:C4021278	hp.json	Duplication of phalanx of the fourth toe|Duplication of 4th toe bone|Partial/complete duplication of the phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0010379		
HP:0010378	biolink:PhenotypicFeature	Triangular shaped phalanges of the 4th toe		UMLS:C4023871	hp.json	Triangular shaped bones of 4th toe	http://purl.obolibrary.org/obo/HP_0010378		
HP:0010377	biolink:PhenotypicFeature	Symphalangism affecting the phalanges of the 4th toe		UMLS:C4023872	hp.json	Fused bones of 4th toe	http://purl.obolibrary.org/obo/HP_0010377		
HP:0010376	biolink:PhenotypicFeature	Patchy sclerosis of 4th toe phalanx	Patchy (irregular) increase in bone density of one or more of the phalanges of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4021279	hp.json	Uneven increase in bone density in 4th toe bone|Patchy sclerosis of the phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0010376		
HP:0010375	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the 4th toe		UMLS:C4023873	hp.json		http://purl.obolibrary.org/obo/HP_0010375		
HP:0010374	biolink:PhenotypicFeature	Curved 4th toe phalanx	A deviation from the normal straight form of one or more phalanges of the fourth toe.	UMLS:C4021280	hp.json	Curved bones of 4th toe|Curved phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0010374		
HP:0010373	biolink:PhenotypicFeature	Bullet-shaped 4th toe phalanx	An abnormal morphology of one or more phalanges of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021281	hp.json	Bullet-shaped phalanges of the 4th toe|Bullet-shaped bones of the 4th toe	http://purl.obolibrary.org/obo/HP_0010373		
HP:0010372	biolink:PhenotypicFeature	Broad phalanges of the 4th toe		UMLS:C4023874	hp.json	Broad bones of the 4th toe	http://purl.obolibrary.org/obo/HP_0010372		
CL:0000197	biolink:Cell	sensory receptor cell	A cell that is capable of detection of a stimulus involved in sensory perception.		hp.json	receptor cell	http://purl.obolibrary.org/obo/CL_0000197		
CL:0000192	biolink:Cell	smooth muscle cell	A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).	FMA:14072|BTO:0004576|CALOHA:TS-2159	hp.json	non-striated muscle cell|smooth muscle fiber|SMCs|myocytes, smooth muscle	http://purl.obolibrary.org/obo/CL_0000192		
HP:0009397	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the 4th finger	Fragmented appearance of the epiphyses of the 4th finger.	UMLS:C4024393	hp.json	Fragmentation of the end part of the ring finger bones	http://purl.obolibrary.org/obo/HP_0009397		
HP:0009396	biolink:PhenotypicFeature	Enlarged epiphyses of the 4th finger	Abnormally large size of the epiphyses of the 4th finger with respect to age-dependent norms.	UMLS:C4024394	hp.json	Enlarged end part of the ring finger bones	http://purl.obolibrary.org/obo/HP_0009396		
HP:0009399	biolink:PhenotypicFeature	Ivory epiphyses of the 4th finger	Sclerosis of the epiphyses of the 4th finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024391	hp.json	Increased bone density of end part of the ring finger bone	http://purl.obolibrary.org/obo/HP_0009399		
HP:0009398	biolink:PhenotypicFeature	Irregular epiphyses of the 4th finger	Irregular radiographic opacity of the epiphyses of the 4th finger.	UMLS:C4024392	hp.json	Irregular end part of the ring finger bones	http://purl.obolibrary.org/obo/HP_0009398		
HP:0034335	biolink:PhenotypicFeature	Inheritance modifier	The terms in this hierarchy can be used to specificy the context in which inheritance of a disease is typically observed.		hp.json		http://purl.obolibrary.org/obo/HP_0034335		
HP:0034334	biolink:PhenotypicFeature	allelic_requirement			hp.json		http://purl.obolibrary.org/obo/HP_0034334		
HP:0034337	biolink:PhenotypicFeature	Claw hand deformity	An abormality of the hand characterized by metacarpophalangeal (MCP) hyperextension and proximal interphalangeal (PIP) and distal interphalangeal (DIP) flexion. The position of the affected hand is said to resemble a claw.		hp.json		http://purl.obolibrary.org/obo/HP_0034337		
HP:0034336	biolink:PhenotypicFeature	Splenic infarction	Ischemia and necrosis of part or all of the spleen resulting from compromise of blood supply resulting from arterial or venous occlusion.		hp.json	Spleen infarct|Spleen infarction|Splenic infarct	http://purl.obolibrary.org/obo/HP_0034336		
HP:0034331	biolink:PhenotypicFeature	McConnell sign	Severe hypokinesia of the mid-free wall of the right ventricle of the heart with a normal contraction of the apical segment of the right ventricle.		hp.json		http://purl.obolibrary.org/obo/HP_0034331		
HP:0034330	biolink:PhenotypicFeature	Regional right ventricular hypokinesis	Decreased range of right ventricular motion in a portion of the right ventricle of the heart.		hp.json		http://purl.obolibrary.org/obo/HP_0034330		
HP:0034333	biolink:PhenotypicFeature	Increased circulating hypoxanthine concentration	Elevated concentration of hypoxanthine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034333		
HP:0034332	biolink:PhenotypicFeature	Cognitive regression	Loss of cognitive developmental skills, as manifested by loss of developmental cognitive milestones.		hp.json		http://purl.obolibrary.org/obo/HP_0034332		
CL:0000163	biolink:Cell	endocrine cell	A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.	FMA:83809	hp.json	endocrinocyte	http://purl.obolibrary.org/obo/CL_0000163		
CL:0000164	biolink:Cell	enteroendocrine cell	An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.	FMA:62930|BTO:0003865	hp.json		http://purl.obolibrary.org/obo/CL_0000164		
CL:0000165	biolink:Cell	neuroendocrine cell	An endocrine cell that has the specialized function to produce and secrete hormones in response to neuronal signals.	BTO:0002691|FMA:83810	hp.json	neurosecretory cell	http://purl.obolibrary.org/obo/CL_0000165		
CL:0000166	biolink:Cell	chromaffin cell	A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system.	FMA:69263|BTO:0000259	hp.json	phaeochromocyte	http://purl.obolibrary.org/obo/CL_0000166		
CL:0000167	biolink:Cell	peptide hormone secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000167		
HP:0034339	biolink:PhenotypicFeature	Pseudoautosomal inheritance	A pattern of inheritance observed for alleles in the X-Y identical regions is referred to as pseudoautosomal inheritance, because it resembles the pattern seen for alleles located on autosomes.		hp.json	Pseudoautosomal region inheritance	http://purl.obolibrary.org/obo/HP_0034339		
UBERON:0022292	biolink:AnatomicalEntity	splenic arteriole		NCIT:C33596	hp.json		http://purl.obolibrary.org/obo/UBERON_0022292		
CL:0000168	biolink:Cell	insulin secreting cell		BTO:0000783	hp.json		http://purl.obolibrary.org/obo/CL_0000168		
HP:0034338	biolink:PhenotypicFeature	Imprinted			hp.json		http://purl.obolibrary.org/obo/HP_0034338		
CL:0000169	biolink:Cell	type B pancreatic cell	A cell that secretes insulin and is located towards the center of the islets of Langerhans.	EV:0200009|ncithesaurus:Beta_Cell|FMA:70586|BTO:0000783|MA:0002419	hp.json	pancreatic beta cell|pancreatic B-cell|beta cell islet|insulin-secreting cell|pancreatic B cell|beta cell of pancreatic islet|type B enteroendocrine cell|pancreatic islet core|B-cell of pancreatic islet|beta cell	http://purl.obolibrary.org/obo/CL_0000169		
UBERON:0022293	biolink:AnatomicalEntity	reproductive gland secretion	A portion of organism substance that is secreted by a reproductive gland.		hp.json	reproductive system fluid/secretion|genital fluid|genital secretion|reproductive system fluid|reproductive system secretion	http://purl.obolibrary.org/obo/UBERON_0022293		
UBERON:0022296	biolink:AnatomicalEntity	inferior palpebral branch of infra-orbital nerve	A nerve that innervates a lower eyelid and is a branch of the infra-orbital branch of the maxillary nerve.	FMA:52983	hp.json	rami palpebrales inferiores nervi infraorbitalis	http://purl.obolibrary.org/obo/UBERON_0022296		
UBERON:0022298	biolink:AnatomicalEntity	lower eyelid nerve	A nerve that innervates a lower eyelid.		hp.json		http://purl.obolibrary.org/obo/UBERON_0022298		
UBERON:0022297	biolink:AnatomicalEntity	palpebral branch of infra-orbital nerve	A nerve that innervates an eyelid and is a branch of the infra-orbital branch of the maxillary nerve.		hp.json	palpebral branch of maxillary nerve	http://purl.obolibrary.org/obo/UBERON_0022297		
UBERON:0022299	biolink:AnatomicalEntity	upper eyelid nerve	A nerve that innervates an upper eyelid.		hp.json		http://purl.obolibrary.org/obo/UBERON_0022299		
CL:0000160	biolink:Cell	goblet cell	A cell of the epithelial lining that produce and secrete mucins.	BTO:0001540|FMA:13148	hp.json	chalice cell	http://purl.obolibrary.org/obo/CL_0000160		
CL:0000161	biolink:Cell	acid secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000161		
HP:0034340	biolink:PhenotypicFeature	Pseudoautosomal dominant inheritance	A type of pseudoautosomal inheritance that is dominant and in which heterozygous males and females both manifest a disease phenotype.		hp.json	monoallelic_PAR	http://purl.obolibrary.org/obo/HP_0034340		
HP:0034346	biolink:PhenotypicFeature	Nesidioblastosis	An abnormality of pancreatic beta cells characterized by a proliferation of abnormal beta cells throughout the entire pancreas, with enlarged islet size and number (hypertrophic islets), increased periductular islets, enlarged beta-cell nuclei and abundant clear cytoplasm. Occasionally beta cells with pleomorphic nuclei, ductuloinsular complexes, and neoformation of islets from ducts are observed.		hp.json		http://purl.obolibrary.org/obo/HP_0034346		
HP:0034345	biolink:PhenotypicFeature	Mendelian inheritance	A mode of inheritance of diseases whose pathophysiology can be traced back to deleterious variants in a single gene. The inheritance patterns of these single-gene (monogenic) diseases are often referred to as Mendelian in honor of Gregor Mendel.		hp.json		http://purl.obolibrary.org/obo/HP_0034345		
HP:0034348	biolink:PhenotypicFeature	Subpulmonary stenosis	A cardiovascular malformation associated with narrowing of the outflow tract of the right ventricle immediately below the pulmonary valve.		hp.json	Subvalvar pulmonary stenosis|Subvalvar pulmonic stenosis|Infundibular pulmonary stenosis|Subvalvular pulmonary stenosis|Subvalvular pulmonic stenosis|Infundibular pulmonic stenosis	http://purl.obolibrary.org/obo/HP_0034348		
HP:0034347	biolink:PhenotypicFeature	Greater auricular nerve thickening	Increase in thickness of the great auricular nerve, a cutaneous nerve of the head. It originates from the cervical plexus, with branches of spinal nerves C2 and C3. Thickening may lead to the nerve being palpable or even visible in this region.		hp.json	Palpable great auricular nerve	http://purl.obolibrary.org/obo/HP_0034347		
HP:0034342	biolink:PhenotypicFeature	Trapezius muscle aplasia	A developmental defect characterized by lack of formation of the trapezius muscle, which is broad superficial muscle that extends from the posterior neck to the posterior part of the trunk (thorax).		hp.json		http://purl.obolibrary.org/obo/HP_0034342		
HP:0034341	biolink:PhenotypicFeature	Pseudoautosomal recessive inheritance	A type of pseudoautosomal inheritance that is recessive and in which biallelic males and females both manifest a disease phenotype.		hp.json	biallelic_PAR	http://purl.obolibrary.org/obo/HP_0034341		
HP:0034344	biolink:PhenotypicFeature	Female-limited expression	Used to refer to a monogenic trait linked to an autosomal locus in which the phenotypic effects of allelic differences are expressed only in the female sex.		hp.json		http://purl.obolibrary.org/obo/HP_0034344		
HP:0034343	biolink:PhenotypicFeature	Requires heterozygosity	A rarely encountered phenomenon in which condition is most severe in the heterozygous state. Such disorders are rare and currently all are X-linked. Most X-linked recessive conditions manifest if hemizygous in males, or biallelic in females, though may have a mild phenotype in the heterozygous state in females.		hp.json		http://purl.obolibrary.org/obo/HP_0034343		
CL:0000174	biolink:Cell	steroid hormone secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000174		
CL:0000177	biolink:Cell	testosterone secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000177		
CL:0000178	biolink:Cell	Leydig cell	A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.	BTO:0000755|CALOHA:TS-1150|FMA:72297|EMAPA:29655	hp.json	interstitial cell|interstitial cell of Leydig	http://purl.obolibrary.org/obo/CL_0000178		
HP:0034349	biolink:PhenotypicFeature	Supravalvar pulmonary stenosis	A cardiovascular malformation associated with narrowing at the level of the pulmonary sinotubular junction above the pulmonic valve.		hp.json	Supravalvar pulmonnic stenosis|Supravalvular pulmonary stenosis|Supravalvular pulmonic stenosis	http://purl.obolibrary.org/obo/HP_0034349		
CL:0000170	biolink:Cell	glucagon secreting cell	A cell that secretes glucagon.	FMA:84045	hp.json	glucagon-secreting cell	http://purl.obolibrary.org/obo/CL_0000170		
CL:0000172	biolink:Cell	somatostatin secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000172		
HP:0034351	biolink:PhenotypicFeature	Neuromyotonia	Peripheral nerve hyperexcitability manifesting as spontaneous discharges originating from motor axons or their terminals, lead to overactivity of muscles, typically manifesting as twitches, cramps and stiffness.		hp.json	Peripheral nerve hyperexcitability	http://purl.obolibrary.org/obo/HP_0034351		
HP:0034350	biolink:PhenotypicFeature	Valvular pulmonary stenosis	A cardiovascular malformation associated with narrowing of the outflow tract of the right ventricle immediately at the level of the pulmonary valve.		hp.json		http://purl.obolibrary.org/obo/HP_0034350		
GO:2001017	biolink:BiologicalProcess	regulation of retrograde axon cargo transport	Any process that modulates the frequency, rate or extent of retrograde axon cargo transport.		hp.json	regulation of retrograde axonal transport	http://purl.obolibrary.org/obo/GO_2001017		
HP:0034357	biolink:PhenotypicFeature	Impaired renal tubular reabsorption of glucose	Increased fractional excretion (FE) of glucose in the urine. The FE of glucose is the percentage of the glucose filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine glucose, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption.		hp.json		http://purl.obolibrary.org/obo/HP_0034357		
CL:0000149	biolink:Cell	visual pigment cell			hp.json	pigment cell	http://purl.obolibrary.org/obo/CL_0000149		
HP:0034356	biolink:PhenotypicFeature	Impaired renal tubular reabsorption of low molecular weight protein	Increased loss of low-molecular weight proteins by the kidneys, measured in terms of the fractional excretion (FE). The FE of low-molecular-weight proteins such as beta2-microglobulin can be measured in terms of plasma and urine concentrations, since urinary low-molecular-weight protein concentrations can vary with water reabsorption.		hp.json	Increased low molecular weight protein excretion	http://purl.obolibrary.org/obo/HP_0034356		
GO:2001018	biolink:BiologicalProcess	negative regulation of retrograde axon cargo transport	Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport.		hp.json	negative regulation of retrograde axonal transport	http://purl.obolibrary.org/obo/GO_2001018		
GO:2001019	biolink:BiologicalProcess	positive regulation of retrograde axon cargo transport	Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport.		hp.json	positive regulation of retrograde axonal transport	http://purl.obolibrary.org/obo/GO_2001019		
HP:0034359	biolink:PhenotypicFeature	Impaired renal tubular reabsorption of phosphate	Increased fractional excretion (FE) of glucose in the phosphate. The FE of glucose is the percentage of the phosphate filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine phosphate, rather than by the interpretation of urinary phosphate concentration alone, as urinary glucose concentrations can vary with water reabsorption.		hp.json		http://purl.obolibrary.org/obo/HP_0034359		
HP:0034358	biolink:PhenotypicFeature	Impaired renal tubular reabsorption of sodium	Increased fractional excretion (FE) of sodium in the urine. The FE of sodium is the percentage of the sodium filtered by the kidney which is excreted in the urine. It is measured in terms of plasma and urine sodium, rather than by the interpretation of urinary glucose concentration alone, as urinary glucose concentrations can vary with water reabsorption.		hp.json		http://purl.obolibrary.org/obo/HP_0034358		
HP:0034353	biolink:PhenotypicFeature	Appendicular spasticity	A type of spasticity that affects one or more limbs (arms or legs).		hp.json		http://purl.obolibrary.org/obo/HP_0034353		
HP:0034352	biolink:PhenotypicFeature	Bile duct polyp	An elevated growth from the the mucosa of the bile duct.		hp.json		http://purl.obolibrary.org/obo/HP_0034352		
HP:0034355	biolink:PhenotypicFeature	White cerebellum sign	On computed tomography of the brain,the white (or dense) cerebellum sign is seen when the cerebellum appears dense with respect to the cerebral parenchyma. The increase in attenuation of cerebellum is in fact a relative hyperdensity caused by decreased attenutation of the brain. It represents anoxic-ischemic cerebral injury, and has a very poor prognosis.		hp.json		http://purl.obolibrary.org/obo/HP_0034355		
HP:0034354	biolink:PhenotypicFeature	Trichoschisis	Transverse fractures through the hair shafts (trichoschisis). Trichoschisis is characterized by a sharp transverse fracture of the hair shaft.		hp.json		http://purl.obolibrary.org/obo/HP_0034354		
GO:2001012	biolink:BiologicalProcess	mesenchymal cell differentiation involved in renal system development	The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state.		hp.json	mesenchymal cell differentiation involved in urinary system development|mesenchymal cell differentiation involved in urinary tract development	http://purl.obolibrary.org/obo/GO_2001012		
CL:0000145	biolink:Cell	professional antigen presenting cell	A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.		hp.json	APC	http://purl.obolibrary.org/obo/CL_0000145		
GO:2001014	biolink:BiologicalProcess	regulation of skeletal muscle cell differentiation	Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2001014		
CL:0000146	biolink:Cell	simple columnar epithelial cell			hp.json		http://purl.obolibrary.org/obo/CL_0000146		
GO:2001015	biolink:BiologicalProcess	negative regulation of skeletal muscle cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2001015		
CL:0000147	biolink:Cell	pigment cell	A pigment cell is a cell that contains pigment granules.	VHOG:0001678	hp.json	chromatophore|chromatocyte	http://purl.obolibrary.org/obo/CL_0000147		
GO:2001016	biolink:BiologicalProcess	positive regulation of skeletal muscle cell differentiation	Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2001016		
CL:0000148	biolink:Cell	melanocyte	A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance.	BTO:0000847|FMA:70545|VHOG:0001679|CALOHA:TS-0613	hp.json	melanophore	http://purl.obolibrary.org/obo/CL_0000148		
HP:0034360	biolink:PhenotypicFeature	Action myoclonus	A type of myoclonus (arrhythmic muscular jerking) that is induced by voluntary movement. It is made worse by attempts at precise or coordinated movement (intention myoclonus) and may also be provoked by certain sensory stimuli.		hp.json		http://purl.obolibrary.org/obo/HP_0034360		
HP:0034362	biolink:PhenotypicFeature	Dull foveal reflex	Reduced brigthness of the foveal reflex, which normally is a bright pinpoint of light that is observed to move sideways or up and down in response to movement of the opthalmoscope.		hp.json	Decreased foveal light reflex|Poor foveal light reflex|Muted foveal light reflex	http://purl.obolibrary.org/obo/HP_0034362		
HP:0034361	biolink:PhenotypicFeature	Redundant umbilical skin	Greater than normal amount of skin surrounding the umbilicus (belly button) with protrusion of the umbilicus above the plane of the abdomen.		hp.json		http://purl.obolibrary.org/obo/HP_0034361		
HP:0034368	biolink:PhenotypicFeature	Urolithiasis	Renal stones are formed within the kidneys, and this is called nephrolithiasis. Urolithiasis is a condition that occurs when these stones exit the renal pelvis and move into the remainder of the urinary collecting system, which includes the ureters, bladder, and urethra.		hp.json		http://purl.obolibrary.org/obo/HP_0034368		
GO:2001028	biolink:BiologicalProcess	positive regulation of endothelial cell chemotaxis	Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_2001028		
HP:0034367	biolink:PhenotypicFeature	Decreased beta-mannosidase activity	Abnormally reduced activity of the enzyme beta-mannosidase, which is a lysosomal enzyme that catabolized oligosaccharides.		hp.json		http://purl.obolibrary.org/obo/HP_0034367		
HP:0034369	biolink:PhenotypicFeature	Decreased level of coenzyme Q10 in skeletal muscle	Reduced amount of coenzyme Q10,a naturally occurring quinone, in skeletal muscle tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0034369		
HP:0034364	biolink:PhenotypicFeature	Fibrofatty replacement of right ventricular myocardium	Replacement of the myocardium of the right ventricular free wall by fat and fibrous tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0034364		
HP:0034363	biolink:PhenotypicFeature	Corneal pterygium	Corneal pterygium is an ocular surface disease characterized mainly by a wing-shaped growth of limbal and conjunctival tissue over the adjacent cornea.		hp.json	Wing-shaped conjunctiva|Surfer's eye	http://purl.obolibrary.org/obo/HP_0034363		
HP:0034366	biolink:PhenotypicFeature	Fracture blister	Fracture blister is a type of blister that forms following acute bone fractures, typically near the ankle, wrist elbow or foot, where skin adheres tightly to bone with little subcutaneous fat cushioning. The blister that results resembles that of a second degree burn.		hp.json		http://purl.obolibrary.org/obo/HP_0034366		
HP:0034365	biolink:PhenotypicFeature	Elevated circulating alpha-aminoadipic semialdehyde concentration	Increased concentration of alpha-aminoadipic semialdehyde in the blood circulation.		hp.json	Elevated circulating piperideine-6-carboxylic acid concentration	http://purl.obolibrary.org/obo/HP_0034365		
CL:0000152	biolink:Cell	exocrine cell	A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct.	FMA:16014	hp.json		http://purl.obolibrary.org/obo/CL_0000152		
GO:2001020	biolink:BiologicalProcess	regulation of response to DNA damage stimulus	Any process that modulates the frequency, rate or extent of response to DNA damage stimulus.		hp.json	regulation of cellular DNA damage response|regulation of DNA damage response|regulation of response to genotoxic stress|regulation of cellular response to DNA damage stimulus	http://purl.obolibrary.org/obo/GO_2001020		
GO:2001021	biolink:BiologicalProcess	negative regulation of response to DNA damage stimulus	Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus.		hp.json	negative regulation of cellular response to DNA damage stimulus|negative regulation of cellular DNA damage response|negative regulation of response to genotoxic stress|negative regulation of DNA damage response	http://purl.obolibrary.org/obo/GO_2001021		
CL:0000153	biolink:Cell	glycosaminoglycan secreting cell	A cell that secretes glycosaminoglycans.		hp.json	hyaluronic acid secreting cell|GAG secreting cell	http://purl.obolibrary.org/obo/CL_0000153		
CL:0000154	biolink:Cell	protein secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000154		
GO:2001022	biolink:BiologicalProcess	positive regulation of response to DNA damage stimulus	Any process that activates or increases the frequency, rate or extent of response to DNA damage stimulus.		hp.json	positive regulation of cellular response to DNA damage stimulus|positive regulation of DNA damage response|positive regulation of cellular DNA damage response|positive regulation of response to genotoxic stress	http://purl.obolibrary.org/obo/GO_2001022		
CL:0000157	biolink:Cell	surfactant secreting cell	A cell that specializes in secretion of surfactant in the alveoli of the lung.		hp.json		http://purl.obolibrary.org/obo/CL_0000157		
GO:2001026	biolink:BiologicalProcess	regulation of endothelial cell chemotaxis	Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_2001026		
CL:0000158	biolink:Cell	club cell	Epithelial progenitor cell of the lung. Club cells are dome-shaped with short microvilli but no cilia. They function to protect the bronchiolar epithelium. Club cells also multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium.	BTO:0004811|FMA:14119	hp.json	bronchiolar non-ciliated cell|Clara cell|club cell of bronchiole	http://purl.obolibrary.org/obo/CL_0000158		
CL:0000159	biolink:Cell	seromucus secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000159		
GO:2001027	biolink:BiologicalProcess	negative regulation of endothelial cell chemotaxis	Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_2001027		
CL:0000150	biolink:Cell	glandular epithelial cell	A specialized epithelial cell that is capable of synthesizing and secreting certain biomolecules.	CALOHA:TS-2085|FMA:86494	hp.json		http://purl.obolibrary.org/obo/CL_0000150		
CL:0000151	biolink:Cell	secretory cell	A cell that specializes in controlled release of one or more substances.	BTO:0003659|FMA:86916	hp.json		http://purl.obolibrary.org/obo/CL_0000151		
HP:0009571	biolink:PhenotypicFeature	Curved middle phalanx of the 2nd finger	Curved appearance of the middle phalanx of the 2nd finger.	UMLS:C4024286	hp.json	Curved middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0009571		
HP:0009570	biolink:PhenotypicFeature	Bullet-shaped middle phalanx of the 2nd finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 2nd finger is affected.	UMLS:C4024287	hp.json	Bullet-shaped middle bone of index finger	http://purl.obolibrary.org/obo/HP_0009570		
UBERON:0010380	biolink:AnatomicalEntity	enteric nerve	The neurons that innervate the esophagus, stomach, small and large bowel.	MA:0001145|EMAPA:37479	hp.json		http://purl.obolibrary.org/obo/UBERON_0010380		pheno_slim
UBERON:0010384	biolink:AnatomicalEntity	lumen of laryngopharynx	An anatomical space that is enclosed by a hypopharynx.	FMA:55096	hp.json	laryngopharynx lumen	http://purl.obolibrary.org/obo/UBERON_0010384		
HP:0010566	biolink:PhenotypicFeature	Hamartoma	A disordered proliferation of mature tissues that is native to the site of origin, e.g., exostoses, nevi and soft tissue hamartomas. Although most hamartomas are benign, some histologic subtypes, e.g., neuromuscular hamartoma, may proliferate aggressively such as mesenchymal cystic hamartoma, Sclerosing epithelial hamartoma, Sclerosing metanephric hamartoma.	SNOMEDCT_US:51398009|MSH:D006222|UMLS:C0018552|SNOMEDCT_US:400006008	hp.json		http://purl.obolibrary.org/obo/HP_0010566		
HP:0010565	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the Epiglottis	This term applies if the Epiglottis is absent or hypoplastic.	UMLS:C4023790	hp.json		http://purl.obolibrary.org/obo/HP_0010565		
HP:0010564	biolink:PhenotypicFeature	Bifid epiglottis	A midline anterior-posterior cleft of the epiglottis that involves at least two-thirds of the epiglottic leaf. It is a useful feature for clinical diagnosis because it appears to be very rare in syndromes other than Pallister-Hall-Syndrome and is also rare as an isolated malformation.	UMLS:C0339864|SNOMEDCT_US:232412004	hp.json		http://purl.obolibrary.org/obo/HP_0010564		
HP:0010562	biolink:PhenotypicFeature	Keloids		SNOMEDCT_US:58405006|MEDDRA:10023330|SNOMEDCT_US:33659008|UMLS:C0022548|MSH:D007627	hp.json		http://purl.obolibrary.org/obo/HP_0010562		hposlim_core
UBERON:0010388	biolink:AnatomicalEntity	proximal segment of rib	The segment of the rib that connects to a vertebra[MP]. a small part of the rib composed of the head, neck, tuberculum and a short proximal part of the body[PMID].	MA:0001400|EMAPA:37495|MA:0001414	hp.json	vertebral part of rib|proximal rib|proximal rib segment|proximal part of rib|costal part of rib	http://purl.obolibrary.org/obo/UBERON_0010388		pheno_slim
HP:0010561	biolink:PhenotypicFeature	Undulate ribs	An abnormally wavy surface or edge of the ribs.	UMLS:C1969185	hp.json	Wavy ribs	http://purl.obolibrary.org/obo/HP_0010561		
HP:0010560	biolink:PhenotypicFeature	Undulate clavicles	An abnormally wavy surface or edge of the clavicles.	UMLS:C4021253	hp.json	Wavy clavicles|Wavy collarbone	http://purl.obolibrary.org/obo/HP_0010560		
UBERON:0010379	biolink:AnatomicalEntity	superior tarsal muscle	The superior tarsal muscle is a smooth muscle adjoining the levator palpebrae superioris muscle that helps to raise the upper eyelid.	FMA:49058	hp.json	the superior tarsal muscle|mueller muscle|Mueller's muscle|Muller's muscle|musculus tarsalis superior|Müller's muscle	http://purl.obolibrary.org/obo/UBERON_0010379		
HP:0010569	biolink:PhenotypicFeature	Elevated 7-dehydrocholesterol	Elevated 7-dehydrocholesterol levels.	UMLS:C1849185	hp.json	Elevated levels of cholesta-5,7-dien-3beta-ol	http://purl.obolibrary.org/obo/HP_0010569		
HP:0009569	biolink:PhenotypicFeature	Broad middle phalanx of the 2nd finger	Increased width of the middle phalanx of the second finger.	UMLS:C4024288	hp.json	Broad middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0009569		
HP:0010568	biolink:PhenotypicFeature	Hamartoma of the eye	A hamartoma (disordered proliferation of mature tissues) which can originate from any tissue of the eye.	UMLS:C4023788	hp.json		http://purl.obolibrary.org/obo/HP_0010568		
HP:0010567	biolink:PhenotypicFeature	Y-shaped metatarsals	Y-shaped metatarsals are the result of a partial fusion of two metatarsal bones, with the two arms of the Y pointing in the distal direction. Y-shaped metatarsals may be seen in combination with polydactyly.	UMLS:C4023789	hp.json	Y-shaped long bone of foot	http://purl.obolibrary.org/obo/HP_0010567		
HP:0009566	biolink:PhenotypicFeature	Short distal phalanx of the 2nd finger	Hypoplasia (congenital reduction in size) of the distal phalanx of the second finger.	UMLS:C4021438	hp.json	Short distal phalanx of the second finger|Short terminal index finger phalanx|Hypoplastic/small distal phalanx of the 2nd finger|Hypoplastic terminal index finger phalanx|Short outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009566		
HP:0009565	biolink:PhenotypicFeature	Aplasia of the distal phalanx of the 2nd finger		UMLS:C4021439	hp.json	Absent outermost index finger bone|Absent terminal index finger phalanx	http://purl.obolibrary.org/obo/HP_0009565		
CHEBI:64709	biolink:ChemicalSubstance	organic acid	Any organic molecular entity that is acidic and contains carbon in covalent linkage.		hp.json	organic acids	http://purl.obolibrary.org/obo/CHEBI_64709		3_STAR
HP:0009568	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanx of the 2nd finger		UMLS:C1862144	hp.json	Absent/underdeveloped middle index finger bone|Hypoplastic/aplastic middle phalanx of index finger|Absent/hypoplastic middle phalanx of 2nd finger|Absent/small middle index finger bone	http://purl.obolibrary.org/obo/HP_0009568		
CHEBI:64708	biolink:ChemicalSubstance	one-carbon compound	An organic molecular entity containing a single carbon atom (C1).		hp.json	one-carbon compounds	http://purl.obolibrary.org/obo/CHEBI_64708		3_STAR
HP:0009562	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the 2nd finger	Uneven (irregular) increase in bone density of the distal phalanx of the second finger.	UMLS:C4024290	hp.json	Uneven increase in bone density in the outermost bone of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009562		
HP:0009561	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanx of the 2nd finger	Dissolution or degeneration of bone tissue of the distal phalanx of the 2nd finger.	UMLS:C4021441	hp.json	Osteolytic defects of the outermost bone of the 2nd finger|Acro-osteolysis of terminal index finger phalanx|Acro-osteolysis of index finger	http://purl.obolibrary.org/obo/HP_0009561		
HP:0009564	biolink:PhenotypicFeature	Triangular shaped distal phalanx of the 2nd finger	Triangular shaped distal phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024289	hp.json	Triangular shaped outermost bone of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009564		
HP:0009563	biolink:PhenotypicFeature	Distal/middle symphalangism of 2nd finger	Fusion of the terminal/distal and middle phalanges of the 2nd finger.	UMLS:C4021440	hp.json	Symphalangism of the distal and middle phalanges of the 2nd finger|Fused outermost and middle index finger bones	http://purl.obolibrary.org/obo/HP_0009563		
HP:0009580	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the proximal phalanx of the 2nd finger		UMLS:C4024281	hp.json	Absent/underdeveloped innermost index finger bone|Absent/small innermost index finger bone	http://purl.obolibrary.org/obo/HP_0009580		
HP:0009582	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the 2nd finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 2nd finger is affected.	UMLS:C4024280	hp.json	Bullet-shaped innermost bone of index finger	http://purl.obolibrary.org/obo/HP_0009582		
HP:0009581	biolink:PhenotypicFeature	Broad proximal phalanx of the 2nd finger	Increased width of the proximal phalanx of the 2nd finger.	UMLS:C4021434	hp.json	Wide/broad proximal index finger phalanx|Wide innermost bone of index finger	http://purl.obolibrary.org/obo/HP_0009581		
UBERON:0010370	biolink:AnatomicalEntity	tibial vein	One of the veins of the lower leg; empty into the popliteal vein.	NCIT:C33787|MA:0002243|EMAPA:37199|UMLS:C0447138	hp.json	vena tibialis	http://purl.obolibrary.org/obo/UBERON_0010370		
CHEBI:25107	biolink:ChemicalSubstance	magnesium atom		Gmelin:16207|WebElements:Mg|DrugBank:DB01378|CAS:7439-95-4|KEGG:C00305	hp.json	12Mg|Mg|Mg|magnesium|Magnesium|magnesium|magnesio	http://purl.obolibrary.org/obo/CHEBI_25107		3_STAR
HP:0010554	biolink:PhenotypicFeature	Cutaneous finger syndactyly	A soft tissue continuity in the A/P axis between two fingers that extends distally to at least the level of the proximal interphalangeal joints, or a soft tissue continuity in the A/P axis between two fingers that lies significantly distal to the flexion crease that overlies the metacarpophalangeal joint of the adjacent fingers.	UMLS:C4021254	hp.json	Webbed skin of fingers|Cutaneous syndactyly of fingers|Cutaneous syndactyly of hands|Webbed fingers	http://purl.obolibrary.org/obo/HP_0010554		hposlim_core
UBERON:0010371	biolink:AnatomicalEntity	ecto-epithelium	Epithelium composed of cells that develops from the ectoderm[FMA,modified].	FMA:69064	hp.json	ectoderm-derived epithelium	http://purl.obolibrary.org/obo/UBERON_0010371		
HP:0010553	biolink:PhenotypicFeature	Oculogyric crisis	An acute dystonic reaction with blepharospasm, periorbital twitches, and protracted fixed staring episodes. There may be a maximal upward deviation of the eyes in the sustained fashion. Oculogyric crisis can be triggered by a number of factors including neuroleptic medications.	UMLS:C0085637|SNOMEDCT_US:5332004	hp.json		http://purl.obolibrary.org/obo/HP_0010553		
HP:0010551	biolink:PhenotypicFeature	Paraplegia/paraparesis	Weakness of both lower extremities with sparing of the upper extremities. Paraplegia refers to a severe or complete loss of strength, whereas paraparesis refers to a relatively mild loss of strength.	UMLS:C4023792	hp.json		http://purl.obolibrary.org/obo/HP_0010551		
UBERON:0010377	biolink:AnatomicalEntity	mesenchyme from somatopleure	Mesenchyme that develops_from a somatopleure.	EHDAA2:0001120	hp.json		http://purl.obolibrary.org/obo/UBERON_0010377		
UBERON:0010378	biolink:AnatomicalEntity	mesenchyme from splanchnopleure	Mesenchyme that develops_from a splanchnopleure.	EHDAA2:0001122	hp.json		http://purl.obolibrary.org/obo/UBERON_0010378		
HP:0010550	biolink:PhenotypicFeature	Paraplegia	Severe or complete weakness of both lower extremities with sparing of the upper extremities.	MSH:D010264|UMLS:C0030486|SNOMEDCT_US:60389000	hp.json	Leg paralysis	http://purl.obolibrary.org/obo/HP_0010550		
UBERON:0010375	biolink:AnatomicalEntity	pancreas dorsal primordium		FMA:79793|EHDAA2:0001384	hp.json	dorsal pancreas	http://purl.obolibrary.org/obo/UBERON_0010375		
UBERON:0010376	biolink:AnatomicalEntity	pancreas ventral primordium		FMA:79794|EHDAA2:0001387	hp.json	ventral pancreas	http://purl.obolibrary.org/obo/UBERON_0010376		
CHEBI:39745	biolink:ChemicalSubstance	dihydrogenphosphate	A monovalent inorganic anion that consists of phosphoric acid in which one of the three OH groups has been deprotonated.	Gmelin:1999|DrugBank:DB02831|PDBeChem:2HP	hp.json	dihydrogenphosphate|[PO2(OH)2](-)|H2PO4(-)|dihydrogentetraoxophosphate(V)|dihydroxidodioxidophosphate(1-)|DIHYDROGENPHOSPHATE ION|dihydrogen(tetraoxidophosphate)(1-)|dihydrogentetraoxophosphate(1-)	http://purl.obolibrary.org/obo/CHEBI_39745		3_STAR
CHEBI:15756	biolink:ChemicalSubstance	hexadecanoic acid	A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	Wikipedia:Palmitic_acid|KNApSAcK:C00001233|PMID:1589452|PMID:16884313|PPDB:1336|PMID:20001317|PMID:28600633|Gmelin:190200|CAS:57-10-3|PMID:16509590|PMID:17502136|PMID:25584012|PMID:17439666|Beilstein:607489|PDBeChem:PLM|Reaxys:607489|KNApSAcK:C00030479|CAS:57-10-3|CAS:57-10-3|PMID:12492626|KEGG:D05341|PMID:15357969|HMDB:HMDB0000220|DrugBank:DB03796|PMID:22735334|KEGG:C00249|LIPID_MAPS_instance:LMFA01010001|MetaCyc:PALMITATE	hp.json	1-Pentadecanecarboxylic acid|C16:0|Palmitic acid|Palmitate|C16 fatty acid|Hexadecylic acid|PALMITIC ACID|n-hexadecoic acid|C16|Hexadecylic acid|n-hexadecanoic acid|palmitic acid|Palmitinic acid|1-hexyldecanoic acid|16:00|cetylic acid|Hexaectylic acid|CH3-[CH2]14-COOH|Hexadecanoate|Palmitinsaeure|Pentadecanecarboxylic acid|FA 16:0|hexadecoic acid|hexadecanoic acid	http://purl.obolibrary.org/obo/CHEBI_15756		3_STAR
UBERON:0010368	biolink:AnatomicalEntity	pulmonary lobule	The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa.	NCIT:C33428|FMA:75739	hp.json	lobulus pulmonis	http://purl.obolibrary.org/obo/UBERON_0010368		human_reference_atlas
HP:0010559	biolink:PhenotypicFeature	Vertical clivus	An abnormal vertical orientation of the clivus (which normally forms a kind of slope from the sella turcica down to the region of the foramen magnum).	UMLS:C1844702	hp.json		http://purl.obolibrary.org/obo/HP_0010559		
HP:0010558	biolink:PhenotypicFeature	Abnormality of the clivus	An abnormality of the clivus, which is the inclined bony region of the posterior cranial fossa located between the sella turcica and the foramen magnum.	UMLS:C4023791	hp.json		http://purl.obolibrary.org/obo/HP_0010558		
HP:0010557	biolink:PhenotypicFeature	Overlapping fingers	A finger resting on the dorsal surface of an adjacent digit when the hand is at rest.	UMLS:C1446712	hp.json		http://purl.obolibrary.org/obo/HP_0010557		hposlim_core
HP:0009577	biolink:PhenotypicFeature	Short middle phalanx of the 2nd finger	Hypoplasia (congenital reduction in size) of the middle phalanx of the second finger, also known as the index finger.	UMLS:C4021435	hp.json	Brachymesophalangy II (finger)|Hypoplastic/small middle phalanx of the 2nd finger|Hypoplastic middle index finger phalanx|Short middle bone of index finger	http://purl.obolibrary.org/obo/HP_0009577		
HP:0009576	biolink:PhenotypicFeature	Absent middle phalanx of 2nd finger	Absence of the middle phalanx of the index (2nd) finger.	UMLS:C4021436	hp.json	Aplasia of the middle phalanx of the 2nd finger|Absent middle phalanx of index finger|Absent middle bone of index finger	http://purl.obolibrary.org/obo/HP_0009576		
HP:0009579	biolink:PhenotypicFeature	Proximal/middle symphalangism of the 2nd finger	Fusion of the proximal and middle phalanges of the 2nd finger.	UMLS:C4024282	hp.json	Fused innermost and middle index finger bones	http://purl.obolibrary.org/obo/HP_0009579		
HP:0009573	biolink:PhenotypicFeature	Patchy sclerosis of the middle phalanx of the 2nd finger	Uneven (irregular) increase in bone density of the middle phalanx of the second finger.	UMLS:C4024285	hp.json	Uneven increase in bone density in the middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0009573		
HP:0009572	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanx of the 2nd finger	Dissolution or degeneration of bone tissue of the middle phalanx of the 2nd finger.	UMLS:C4021437	hp.json	Lytic defects of middle index finger phalanx	http://purl.obolibrary.org/obo/HP_0009572		
HP:0009575	biolink:PhenotypicFeature	Triangular shaped middle phalanx of the 2nd finger	Triangular shaped middle phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024283	hp.json	Triangular shaped middle bone of index finger	http://purl.obolibrary.org/obo/HP_0009575		
HP:0009574	biolink:PhenotypicFeature	Symphalangism of middle phalanx of 2nd finger	Fusion of the middle phalanx of the 2nd finger with another bone.	UMLS:C4024284	hp.json	Fused middle bone of index finger	http://purl.obolibrary.org/obo/HP_0009574		
HP:0010544	biolink:PhenotypicFeature	Vertical nystagmus	Vertical nystagmus may present with either up-beating or down-beating eye movements or both. When present in the straight-ahead position of gaze it is referred to as upbeat nystagmus or downbeat nystagmus.	UMLS:C0271386|SNOMEDCT_US:111533001|MSH:D009759	hp.json		http://purl.obolibrary.org/obo/HP_0010544		hposlim_core
UBERON:0010362	biolink:AnatomicalEntity	endoskeleton	Skeletal subdivision that undergoes indirect development and includes elements that develop as a replacement or substitution of other elements or tissues.	XAO:0004026|VSAO:0000037|Wikipedia:Endoskeleton	hp.json	replacement skeleton	http://purl.obolibrary.org/obo/UBERON_0010362		
UBERON:0010363	biolink:AnatomicalEntity	endochondral element	A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification.	XAO:0004017|ZFA:0005620|VSAO:0000139	hp.json	endochondral replacement element	http://purl.obolibrary.org/obo/UBERON_0010363		
HP:0010543	biolink:PhenotypicFeature	Opsoclonus	Bursts of large-amplitude multidirectional saccades without intersaccadic interval	SNOMEDCT_US:194177006|MSH:D015835|UMLS:C0242567	hp.json		http://purl.obolibrary.org/obo/HP_0010543		
HP:0010542	biolink:PhenotypicFeature	Vestibular nystagmus	Nystagmus due to disturbance of the vestibular system; eye movements are rhythmic, with slow and fast components.	UMLS:C0155379|SNOMEDCT_US:46888001	hp.json		http://purl.obolibrary.org/obo/HP_0010542		
UBERON:0010360	biolink:AnatomicalEntity	pharyngeal arch mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a entire pharyngeal arch associated mesenchyme.		hp.json	arch mesenchyme from head mesenchyme|branchial arch mesenchyme from head mesenchyme|head mesenchyme derived arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010360		
HP:0010541	biolink:PhenotypicFeature	Cutis gyrata of scalp	The presence of convoluted folds and furrows formed from thickened skin of the scalp, resembling cerebriform pattern. The scalp has convoluted and elevated folds, 1 to 2 cm in thickness. The convolutions generally cannot be flattened by traction.	UMLS:C4072877|SNOMEDCT_US:51603000|UMLS:C4280378|UMLS:C0263417	hp.json	Scalp rugae|Thickened folds on top of scalp|Cutis verticis gyrata|Scalp folds|Thickening of the scalp|Furrows in thickened skin on top of scalp|Scalp furrows	http://purl.obolibrary.org/obo/HP_0010541		
HP:0010540	biolink:PhenotypicFeature	Advanced pneumatization of cranial sinuses	A degree of pneumatization that is increased compared to age-related norms.	UMLS:C4023793	hp.json		http://purl.obolibrary.org/obo/HP_0010540		
UBERON:0010366	biolink:AnatomicalEntity	conjunctival vasculature	A vasculature that is part of a conjunctiva.	FMA:70887	hp.json	venae conjunctivales|conjunctival veins set|conjunctival veins|set of conjunctival veins	http://purl.obolibrary.org/obo/UBERON_0010366		
UBERON:0010367	biolink:AnatomicalEntity	conjunctival vein	A vein that is part of a conjunctiva.	FMA:70887	hp.json	conjunctival blood vessel	http://purl.obolibrary.org/obo/UBERON_0010367		
UBERON:0010364	biolink:AnatomicalEntity	dermal skeleton	Skeletal subdivision that undergoes direct development and includes elements that either develop in association with the basement membrane of the ectoderm or are homologous with such elements; includes dermatocranium, components of the appendicular skeleton, teeth and tooth-like elements of the oropharynx, and integumentary elements.	XAO:0004025|VSAO:0000035	hp.json	dermal skeletal system|desmoskeleton|exoskeleton|dermoskeleton	http://purl.obolibrary.org/obo/UBERON_0010364		
UBERON:0010365	biolink:AnatomicalEntity	odontoid tissue	Skeletal tissue that is part of the exoskeleton and derived from an odontogenic papilla.	EMAPA:35872|UMLS:C1519551|VSAO:0000063|ZFA:0005623|XAO:0004046|MA:0002540|NCIT:C33794|FMA:63001	hp.json	substance of tooth|portion of substance of tooth|dental tissue|tooth hard tissue|tooth tissue|tooth substance|odontogenic tissue	http://purl.obolibrary.org/obo/UBERON_0010365		uberon_slim
UBERON:0010359	biolink:AnatomicalEntity	pharyngeal arch mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a entire pharyngeal arch associated mesenchyme.		hp.json	neural crest derived arch mesenchyme|branchial arch mesenchyme from neural crest|arch mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0010359		
UBERON:0010358	biolink:AnatomicalEntity	arch of centrum of vertebra	An arch-shaped structure of the vertebra that extends dorsally (neural arch) or ventrally (hemal arch) from the vertebral centrum.	FMA:11946|EMAPA:36614	hp.json	vertebra arch|vertebral arch|arcus vertebrae (vertebralis)|arch of vertebra	http://purl.obolibrary.org/obo/UBERON_0010358		pheno_slim
HP:0010549	biolink:PhenotypicFeature	Weakness due to upper motor neuron dysfunction	Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Paralysis due to lesions of the principle motor tracts is related to a lesion in the corticospinal, corticobulbar or brainstem descending (subcorticospinal) neurons.	UMLS:C4021255	hp.json	Paralysis due to lesions of the principle motor tracts	http://purl.obolibrary.org/obo/HP_0010549		
HP:0010548	biolink:PhenotypicFeature	Percussion myotonia	A localized myotonic contraction in a muscle in reaction to percussion (tapping with the examiner's finger, a rubber percussion hammer, or a similar object).	UMLS:C0751359|MSH:D009222	hp.json	Transient swelling of muscle induced by percussion	http://purl.obolibrary.org/obo/HP_0010548		
HP:0009548	biolink:PhenotypicFeature	Bullet-shaped phalanges of the 2nd finger	A second finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4024300	hp.json	Bullet-shaped index finger bones	http://purl.obolibrary.org/obo/HP_0009548		
HP:0009547	biolink:PhenotypicFeature	Broad phalanges of the 2nd finger		UMLS:C4021444	hp.json	Wide/broad index finger phalanges|Wide index finger bones	http://purl.obolibrary.org/obo/HP_0009547		
HP:0010547	biolink:PhenotypicFeature	Muscle flaccidity	A type of paralysis in which a muscle becomes soft and yields to passive stretching, which results from loss of all or practically all peripheral motor nerves that innervated the muscle. Muscle tone is reduced and the affected muscles undergo extreme atrophy within months of the loss of innervation.	SNOMEDCT_US:397488002|SNOMEDCT_US:186611004|MSH:D009123|UMLS:C0026825	hp.json		http://purl.obolibrary.org/obo/HP_0010547		
HP:0010546	biolink:PhenotypicFeature	Muscle fibrillation	Fine, rapid twitching of individual muscle fibers with little or no movement of the muscle as a whole. If a motor neuron or its axon is destroyed, the muscle fibers it innervates undergo denervation atrophy. This leads to hypersensitivity of individual muscle fibers to acetyl choline so that they may contract spontaneously. Isolated activity of individual muscle fibers is generally so fine it cannot be seen through the intact skin, although it can be recorded as a short-duration spike in the EMG.	UMLS:C0231531|SNOMEDCT_US:41405005	hp.json	Twitching	http://purl.obolibrary.org/obo/HP_0010546		
HP:0010545	biolink:PhenotypicFeature	Downbeat nystagmus	Downbeat nystagmus is a type of fixation nystagmus with the fast phase beating in a downward direction. It generally increases when looking to the side and down and when lying prone.	UMLS:C0585544|SNOMEDCT_US:307676006	hp.json		http://purl.obolibrary.org/obo/HP_0010545		
HP:0009549	biolink:PhenotypicFeature	Curved phalanges of the 2nd finger		UMLS:C4024299	hp.json	Curved index finger bones	http://purl.obolibrary.org/obo/HP_0009549		
HP:0009544	biolink:PhenotypicFeature	Abnormality of the proximal phalanx of the 2nd finger		UMLS:C4021447	hp.json	Abnormality of the proximal 2nd finger phalanx|Abnormal innermost index finger bone	http://purl.obolibrary.org/obo/HP_0009544		
HP:0009543	biolink:PhenotypicFeature	Abnormality of the middle phalanx of the 2nd finger		UMLS:C4021448	hp.json	Abnormal middle index finger bone|Abnormality of middle 2nd finger phalanx	http://purl.obolibrary.org/obo/HP_0009543		
HP:0009546	biolink:PhenotypicFeature	Triangular shaped phalanges of the 2nd finger	Triangular shaped phalanges of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4021445	hp.json	Triangular index finger phalanges|Triangular bones of index finger	http://purl.obolibrary.org/obo/HP_0009546		
HP:0009545	biolink:PhenotypicFeature	Symphalangism of the 2nd finger		UMLS:C4021446	hp.json	Fused index finger bones|Symphalangism of index finger phalanges	http://purl.obolibrary.org/obo/HP_0009545		
HP:0009540	biolink:PhenotypicFeature	Contracture of the proximal interphalangeal joint of the 2nd finger	Chronic loss of joint motion of the proximal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue.	UMLS:C4021451	hp.json	Camptodactyly of second finger|Camptodactyly of index finger|Camptodactyly of 2nd finger	http://purl.obolibrary.org/obo/HP_0009540		
HP:0009542	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the 2nd finger		UMLS:C4021449	hp.json	Abnormality of terminal index finger phalanx|Abnormality of the outermost bone of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009542		
HP:0009541	biolink:PhenotypicFeature	Abnormality of the phalanges of the 2nd finger	Abnormality of the phalanges of the 2nd (index) finger.	UMLS:C4021450	hp.json	Abnormal index finger bones|Abnormality of 2nd finger phalanges	http://purl.obolibrary.org/obo/HP_0009541		
HP:0009560	biolink:PhenotypicFeature	Curved distal phalanx of the 2nd finger	Curved appearance of the distal phalanx of the 2nd finger.	UMLS:C4024291	hp.json	Curved outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009560		
HP:0010533	biolink:PhenotypicFeature	Spasmus nutans	The combination of pendular nystagmus, head nodding, and torticollis.	MSH:D013036|UMLS:C0546878|SNOMEDCT_US:18191000	hp.json		http://purl.obolibrary.org/obo/HP_0010533		
HP:0010532	biolink:PhenotypicFeature	Paroxysmal vertigo	Paroxysmal episodes of vertigo.	SNOMEDCT_US:103290003|UMLS:C0522357|MSH:D014717	hp.json		http://purl.obolibrary.org/obo/HP_0010532		
HP:0010531	biolink:PhenotypicFeature	Spinal myoclonus	Spinal myoclonus is generally due to a tumor, infection, injury, or degenerative process of the spinal cord, and is characterized by involuntary rhythmic muscle contractions, usually at a rate of more than one per second. Myoclonus occurs synchronously in several muscles and can be increased in severity and frequency by fatigue or stress, but is usually unaffected by sensory stimuli. Spinal myoclonus ceases during sleep or anesthesia.	SNOMEDCT_US:698836007|UMLS:C3697670	hp.json		http://purl.obolibrary.org/obo/HP_0010531		
HP:0010530	biolink:PhenotypicFeature	Palatal tremor	Palatal tremor (PT) is an involuntary, rhythmic and oscillatory movement of the soft palate. PT is a rare type of tremor involving the soft palate. It can be unilateral or bilateral.	MSH:D009207|SNOMEDCT_US:9366002|UMLS:C0030214	hp.json	Palatal myoclonus	http://purl.obolibrary.org/obo/HP_0010530		
UBERON:0010355	biolink:AnatomicalEntity	ossification center	The first step in ossification of the cartilage is that the cartilage cells, at the point where ossification is commencing and which is termed a ossification center, enlarge and arrange themselves in rows. The matrix in which they are imbedded increases in quantity, so that the cells become further separated from each other. A deposit of calcareous material now takes place in this matrix, between the rows of cells, so that they become separated from each other by longitudinal columns of calcified matrix, presenting a granular and opaque appearance. Here and there the matrix between two cells of the same row also becomes calcified, and transverse bars of calcified substance stretch across from one calcareous column to another. Thus there are longitudinal groups of the cartilage cells enclosed in oblong cavities, the walls of which are formed of calcified matrix which cuts off all nutrition from the cells; the cells, in consequence, atrophy, leaving spaces called the primary areolC&.	FMA:75436	hp.json	ossification centre|centrum ossificationis|center of ossification|centrum ossificationis	http://purl.obolibrary.org/obo/UBERON_0010355		pheno_slim
UBERON:0010354	biolink:AnatomicalEntity	Reichert's cartilage pre-cartilage condensation		EMAPA:17351	hp.json	future Reichert's cartilage|hyoid cartilage pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010354		
UBERON:0010348	biolink:AnatomicalEntity	hyoid pre-muscle mass		EHDAA2:0000795	hp.json	hyoid muscle plate	http://purl.obolibrary.org/obo/UBERON_0010348		
CHEBI:15778	biolink:ChemicalSubstance	N-acyl-D-amino acid	Any N-acyl-amino acid in which the amino acid moiety has D configuration.		hp.json		http://purl.obolibrary.org/obo/CHEBI_15778		3_STAR
UBERON:0010349	biolink:AnatomicalEntity	otic capsule pre-cartilage condensation	An otic capsule endochondral element that is composed primarily of a pre-cartilage condensation.	EHDAA2:0000833	hp.json	otic capsule anlage	http://purl.obolibrary.org/obo/UBERON_0010349		
HP:0010539	biolink:PhenotypicFeature	Thin calvarium	The presence of an abnormally thin calvarium.	UMLS:C1856231|UMLS:C4280379	hp.json	Thin skull bone|Thin cranial bone	http://purl.obolibrary.org/obo/HP_0010539		hposlim_core
UBERON:0010347	biolink:AnatomicalEntity	6th arch mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 6th arch mesenchyme.	EHDAA2:0004078	hp.json	head mesenchyme derived arch 6 mesenchyme|branchial arch 6 mesenchyme from head mesenchyme|pharyngeal arch 6 mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010347		
HP:0010538	biolink:PhenotypicFeature	Small sella turcica	An abnormally small sella turcica.	UMLS:C4023794|UMLS:C4072876|UMLS:C4072875	hp.json	Small pituitary fossa|Hypoplasia of sella turcica|Hypoplasia of pituitary fossa|Hypoplasia of hypophseal fossa|Small hypophyseal fossa	http://purl.obolibrary.org/obo/HP_0010538		hposlim_core
HP:0010537	biolink:PhenotypicFeature	Wide cranial sutures	An abnormally increased width of the cranial sutures for age-related norms (generally resulting from delayed closure).	UMLS:C0410935|SNOMEDCT_US:268855009	hp.json	Broad cranial sutures|Widened cranial sutures|open cranial sutures|Persistent open cranial sutures|Large cranial suture	http://purl.obolibrary.org/obo/HP_0010537		hposlim_core
HP:0009559	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the 2nd finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 2nd finger is affected.	UMLS:C4024292	hp.json	Bullet-shaped outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009559		
HP:0010536	biolink:PhenotypicFeature	Central sleep apnea	Sleep apnea resulting from a transient abolition of the central drive to the ventilatory muscles.	MSH:D020182|UMLS:C0520680	hp.json	Central sleep apnoea	http://purl.obolibrary.org/obo/HP_0010536		
HP:0009558	biolink:PhenotypicFeature	Broad distal phalanx of the 2nd finger	Increased width of the distal phalanx of the 2nd finger.	UMLS:C4024293	hp.json	Wide outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009558		
HP:0010535	biolink:PhenotypicFeature	Sleep apnea	An intermittent cessation of airflow at the mouth and nose during sleep. Apneas of at least 10 seconds are considered important, but persons with sleep apnea may have apneas of 20 seconds to up to 2 or 3 minutes. Patients may have up to 15 events per hour of sleep.	MSH:D012891|UMLS:C0037315|SNOMEDCT_US:73430006	hp.json	Pauses in breathing while sleeping|Sleep apnoea	http://purl.obolibrary.org/obo/HP_0010535		
HP:0010534	biolink:PhenotypicFeature	Transient global amnesia	A paroxysmal, transient loss of memory function with preservation of immediate recall and remote memory but with a severe impairment of memory for recent events and ability to retain new information.	UMLS:C0338591|SNOMEDCT_US:230736007|MSH:D020236	hp.json		http://purl.obolibrary.org/obo/HP_0010534		
HP:0009555	biolink:PhenotypicFeature	Hypoplasia of the pharynx	Underdevelopment of the pharynx.	UMLS:C4280396|UMLS:C4024295|UMLS:C4280400|UMLS:C4280399|UMLS:C4280398|UMLS:C4280397	hp.json	Hypotrophic pharynx|Decreased length of pharynx|Small pharynx|Decreased size of pharynx|Decreased volume of pharynx|Decreased diameter of pharynx|Underdevelopment of pharynx|Decreased width of pharynx	http://purl.obolibrary.org/obo/HP_0009555		
HP:0009554	biolink:PhenotypicFeature	Preauricular hair displacement	An tongue-like extension of hair towards the cheeks, in which hair growth extends in front of the ear to the lateral cheekbones.	UMLS:C4024296	hp.json	Hair displacement, preauricular, towards lateral cheekbone|Projection of scalp hair onto lateral cheek|Hair growing down to cheek	http://purl.obolibrary.org/obo/HP_0009554		
HP:0009557	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the 2nd finger		UMLS:C4024294	hp.json	Absent/underdeveloped outermost index finger bone|Absent/small outermost index finger bone	http://purl.obolibrary.org/obo/HP_0009557		
HP:0009556	biolink:PhenotypicFeature	Absent tibia	Absence of the tibia.	UMLS:C3276744	hp.json	Absent shankbone|Absent shinbone|Aplasia of the tibia	http://purl.obolibrary.org/obo/HP_0009556		hposlim_core
HP:0009551	biolink:PhenotypicFeature	Patchy sclerosis of 2nd finger phalanx	Uneven (irregular) increase in bone density of one or more of the phalanges of the 2nd finger.	UMLS:C4021442	hp.json	Patchy sclerosis of the phalanges of the 2nd finger|Uneven increase in bone density in index finger bone	http://purl.obolibrary.org/obo/HP_0009551		
HP:0009550	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the 2nd finger		UMLS:C4021443	hp.json	Lytic defect in index finger phalanges	http://purl.obolibrary.org/obo/HP_0009550		
OIO:hasAlternativeId	biolink:NamedThing	has_alternative_id			hp.json		http://www.geneontology.org/formats/oboInOwl#hasAlternativeId		
HP:0009553	biolink:PhenotypicFeature	Abnormality of the hairline	The hairline refers to the outline of hair of the head. An abnormality of the hairline can refer to an unusually low or high border between areas of the scalp with and without hair or to abnormal projections of scalp hair.	UMLS:C4024297	hp.json	Abnormality of the hairline	http://purl.obolibrary.org/obo/HP_0009553		
HP:0009552	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the 2nd finger		UMLS:C4024298	hp.json	Absent/underdeveloped index finger bone|Absent/small index finger bone	http://purl.obolibrary.org/obo/HP_0009552		
CHEBI:76725	biolink:ChemicalSubstance	EC 1.* (oxidoreductase) inhibitor	An enzyme inhibitor which interferes with the action of an oxidoreductase (EC 1.*.*.*).	Wikipedia:Oxidoreductase	hp.json	EC 1.* inhibitors|oxidoreductase (EC 1.*) inhibitor|oxidoreductase inhibitor|oxidoreductase inhibitors|oxidoreductase (EC 1.*) inhibitors|EC 1.* (oxidoreductase) inhibitors|EC 1.* inhibitor	http://purl.obolibrary.org/obo/CHEBI_76725		3_STAR
CHEBI:76726	biolink:ChemicalSubstance	EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor	An oxidoreductase inhibitor which interferes with the action of an oxidoreductase acting on the CH-OH group of donors (EC 1.1.*.*).		hp.json	oxidoreductase acting on donor CH-OH group inhibitors|oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitors|EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitors|EC 1.1.* inhibitors|inhibitor of oxidoreductase acting on CH-OH group of donors|inhibitors of oxidoreductase acting on CH-OH group of donors|inhibitors of oxidoreductase acting on CH-OH group of donor|EC 1.1.* inhibitor|inhibitor of oxidoreductase acting on CH-OH group of donor|oxidoreductase acting on donor CH-OH group (EC 1.1.*) inhibitor|oxidoreductase acting on donor CH-OH group inhibitor	http://purl.obolibrary.org/obo/CHEBI_76726		3_STAR
CHEBI:15727	biolink:ChemicalSubstance	carnosine	A dipeptide that is the N-(beta-alanyl) derivative of L-histidine.	PMID:17031479|PMID:20017611|CAS:305-84-0|PMID:17443912|PMID:16181134|PMID:11976203|CAS:305-84-0|Reaxys:87671|PMID:33586561|PMID:16162015|KNApSAcK:C00052222|HMDB:HMDB0000033|PMID:15853927|DrugBank:DB11695|PMID:29463897|PMID:16804013|Chemspider:388363|PMID:20681748|PMID:15941308|PMID:8689392|PMID:10841274|PMID:11707898|PMID:24398899|PMID:33704575|PMID:1735411|PMID:18076890|Wikipedia:Carnosine|PMID:16287364|PMID:18773880|KEGG:C00386|PMID:18019400|PMID:10951108|PMID:11470131|PMID:19309105|PMID:12139778|PDBeChem:8V0|PMID:31951767|PMID:16406688|PMID:9928418|PMID:34067694|PMID:10951105|PMID:15878720|PMID:2674258|PMID:9029640|PMID:11911459	hp.json	N-beta-alanyl-L-histidine|ignotine|beta-alanyl-L-histidine|Carnosine|beta-alanyl-L-histidine|(2S)-2-(3-aminopropanamido)-3-(1H-imidazol-4-yl)propanoic acid|N(alpha)-(beta-alanyl)-L-histidine|N-2-M|Nalpha-(beta-alanyl)-L-histidine|N-(3-aminopropanoyl)-L-histidine|L-carnosine|Karnozin|Karnozzn	http://purl.obolibrary.org/obo/CHEBI_15727		3_STAR
HP:0010591	biolink:PhenotypicFeature	Abnormality of the proximal tibial epiphysis	Any abnormality of the proximal epiphysis of the tibia.	UMLS:C4023782	hp.json	Abnormality of the end part of innermost shankbone|Abnormality of the end part of innermost shinbone	http://purl.obolibrary.org/obo/HP_0010591		
HP:0010590	biolink:PhenotypicFeature	Abnormality of the distal femoral epiphysis	Any abnormality of the distal epiphysis of the femur.	UMLS:C4023783	hp.json	Abnormality of the end part of the outermost thighbone	http://purl.obolibrary.org/obo/HP_0010590		
HP:0010599	biolink:PhenotypicFeature	Abnormality of the distal humeral epiphysis	Any abnormality of the distal epiphysis of the humerus.	UMLS:C4023774	hp.json	Abnormality of the end part of the outermost long bone in upper arm	http://purl.obolibrary.org/obo/HP_0010599		
HP:0010598	biolink:PhenotypicFeature	Abnormality of the proximal humeral epiphysis	Any abnormality of the proximal epiphysis of the humerus.	UMLS:C4023775	hp.json	Abnormality of the end part of the innermost long bone in upper arm	http://purl.obolibrary.org/obo/HP_0010598		
HP:0010597	biolink:PhenotypicFeature	Abnormality of the distal radial epiphysis	Any abnormality of the distal epiphysis of the radius.	UMLS:C4023776	hp.json		http://purl.obolibrary.org/obo/HP_0010597		
HP:0010596	biolink:PhenotypicFeature	Abnormality of the proximal radial epiphysis	Any abnormality of the proximal epiphysis of the radius.	UMLS:C4023777	hp.json		http://purl.obolibrary.org/obo/HP_0010596		
HP:0010595	biolink:PhenotypicFeature	Abnormality of the distal fibular epiphysis	Any abnormality of the distal epiphysis of the fibula.	UMLS:C4023778	hp.json	Abnormality of the outermost end part of calf bone	http://purl.obolibrary.org/obo/HP_0010595		
HP:0010594	biolink:PhenotypicFeature	Abnormality of the proximal fibular epiphysis	Any abnormality of the proximal epiphysis of the fibula.	UMLS:C4023779	hp.json	Abnormality of the innermost end part of calf bone	http://purl.obolibrary.org/obo/HP_0010594		
HP:0010593	biolink:PhenotypicFeature	Abnormality of fibular epiphyses		UMLS:C4023780	hp.json	Abnormality of the end part of the calf bone	http://purl.obolibrary.org/obo/HP_0010593		
HP:0010592	biolink:PhenotypicFeature	Abnormality of the distal tibial epiphysis		UMLS:C4023781	hp.json	Abnormality of the end part of outermost shinbone|Abnormality of the end part of outermost shankbone	http://purl.obolibrary.org/obo/HP_0010592		
HP:0010580	biolink:PhenotypicFeature	Enlarged epiphyses	Increased size of epiphyses.	UMLS:C1833328	hp.json	Large end part of bone|Widened, distorted epiphyses|Large epiphyses	http://purl.obolibrary.org/obo/HP_0010580		
HP:0009591	biolink:PhenotypicFeature	Abnormality of the vestibulocochlear nerve	Abnormality of the vestibulocochlear nerve, the eighth cranial nerve, which is involved in transmitting sound and equilibrium information from the inner ear to the brain.	UMLS:C4021431	hp.json	Abnormality of the eighth cranial nerve|Abnormality of the VIIIth cranial nerve	http://purl.obolibrary.org/obo/HP_0009591		
HP:0009590	biolink:PhenotypicFeature	Unilateral vestibular schwannoma	A unilateral vestibular Schwannoma (acoustic neurinoma).	UMLS:C1863653	hp.json		http://purl.obolibrary.org/obo/HP_0009590		
HP:0009593	biolink:PhenotypicFeature	Peripheral Schwannoma	The presence of a peripheral schwannoma.	UMLS:C4024276	hp.json		http://purl.obolibrary.org/obo/HP_0009593		
HP:0009592	biolink:PhenotypicFeature	Astrocytoma	Astrocytoma is a neoplasm of the central nervous system derived from astrocytes. Astrocytes are a type of glial cell, and thus astrocytoma is a subtype of glioma.	UMLS:C0004114|SNOMEDCT_US:38713004|MSH:D001254	hp.json		http://purl.obolibrary.org/obo/HP_0009592		
UBERON:0036990	biolink:AnatomicalEntity	wall of pharyngotympanic tube		FMA:60069	hp.json	pharyngotympanic tube wall	http://purl.obolibrary.org/obo/UBERON_0036990		
HP:0010588	biolink:PhenotypicFeature	Premature epimetaphyseal fusion	Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at each end of a long bone, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.	UMLS:C0151628|SNOMEDCT_US:89493005	hp.json	Premature closure of epiphyses	http://purl.obolibrary.org/obo/HP_0010588		
HP:0010587	biolink:PhenotypicFeature	Triangular epiphyses		UMLS:C4023784	hp.json	Triangular end part of bone	http://purl.obolibrary.org/obo/HP_0010587		
HP:0010585	biolink:PhenotypicFeature	Small epiphyses	Reduction in the size or volume of epiphyses.	UMLS:C1846803	hp.json	Small end part of bone	http://purl.obolibrary.org/obo/HP_0010585		
HP:0010584	biolink:PhenotypicFeature	Pseudoepiphyses		UMLS:C1841685	hp.json		http://purl.obolibrary.org/obo/HP_0010584		
HP:0010583	biolink:PhenotypicFeature	Ivory epiphyses	Sclerosis of the epiphyses, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C1856911	hp.json	Increased bone density in end part of bone|Epiphyseal sclerosis	http://purl.obolibrary.org/obo/HP_0010583		
HP:0010582	biolink:PhenotypicFeature	Irregular epiphyses	An alteration of the normally smooth contour of the epiphysis leading to an irregular appearance.	UMLS:C1846449	hp.json	Irregular end part of long bone	http://purl.obolibrary.org/obo/HP_0010582		
CHEBI:64767	biolink:ChemicalSubstance	anionic group	A group that carries an overall negative charge.		hp.json	anionic groups	http://purl.obolibrary.org/obo/CHEBI_64767		3_STAR
HP:0009588	biolink:PhenotypicFeature	Vestibular schwannoma	A vestibular schwannoma (also known as acoustic neuroma, acoustic neurinoma, or acoustic neurilemoma) is a benign, usually slow-growing tumor that develops from the VIIIth cranial nerve supplying the inner ear.	NCIT:C3269|SNOMEDCT_US:126949007|MSH:D009464|SNOMEDCT_US:985004|UMLS:C0027859	hp.json	Vestibular Schwann cell tumor|Vestibular neurolemmoma|Vestibular neurinoma|Vestibular neurilemmoma|Acoustic Neuroma|Vestibular Schwann cell tumour	http://purl.obolibrary.org/obo/HP_0009588		hposlim_core
UBERON:0022351	biolink:AnatomicalEntity	parietal serous membrane	Serous membrane layer that lines to a body cavity.	FMA:15859|MA:0002448	hp.json	parietal wall of serous membrane|cavity lining	http://purl.obolibrary.org/obo/UBERON_0022351		
UBERON:0022350	biolink:AnatomicalEntity	visceral serous membrane	Serous membrane layer that is adjacent to and lines an organ.	FMA:15860	hp.json	visceral wall of serous membrane	http://purl.obolibrary.org/obo/UBERON_0022350		
HP:0009587	biolink:PhenotypicFeature	Triangular shaped proximal phalanx of the 2nd finger	Triangular shaped proximal phalanx of the 2nd finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4021432	hp.json	Triangular proximal index finger phalanx|Triangular shaped innermost bone of index finger	http://purl.obolibrary.org/obo/HP_0009587		
CHEBI:15740	biolink:ChemicalSubstance	formate	A monocarboxylic acid anion that is the conjugate base of formic acid. Induces severe metabolic acidosis and ocular injury in human subjects.	KEGG:C00058|PMID:17190852|CAS:71-47-6|MetaCyc:FORMATE|Gmelin:1006|Wikipedia:Formate|UM-BBD_compID:c0106|CAS:71-47-6|PMID:3946945|HMDB:HMDB0000142|Reaxys:1901205|Beilstein:1901205	hp.json	formiate|methanoate|formylate|hydrogen carboxylate|formate|HCO2 anion|aminate|formate|formic acid, ion(1-)	http://purl.obolibrary.org/obo/CHEBI_15740		3_STAR
OBO:chebi#is_conjugate_base_of	biolink:NamedThing	is conjugate base of			hp.json		http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of		
HP:0009589	biolink:PhenotypicFeature	Bilateral vestibular schwannoma	A bilateral vestibular Schwannoma (acoustic neurinoma).	MSH:D016518|UMLS:C1136042	hp.json	Bilateral acoustic neuromas	http://purl.obolibrary.org/obo/HP_0009589		
UBERON:0022355	biolink:AnatomicalEntity	basal layer of endometrium	The layer of endometrial epithelium adjacent to the uterine cavity.	FMA:86492|NCIT:C32189	hp.json	stratum basalis of endometrium|pars basalis of endometrium	http://purl.obolibrary.org/obo/UBERON_0022355		human_reference_atlas
HP:0009584	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanx of the 2nd finger	Dissolution or degeneration of bone tissue of the proximal phalanx of the 2nd finger.	UMLS:C4021433	hp.json	Lytic defects of proximal index finger phalanx	http://purl.obolibrary.org/obo/HP_0009584		
HP:0009583	biolink:PhenotypicFeature	Curved proximal phalanx of the 2nd finger	Curved appearance of the proximal phalanx of the 2nd finger.	UMLS:C4024279	hp.json	Curved innermost bone of index finger	http://purl.obolibrary.org/obo/HP_0009583		
HP:0009586	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanx of the 2nd finger	Fusion of the proximal phalanx of the 2nd finger with another bone.	UMLS:C4024277	hp.json	Fused innermost bone of index finger	http://purl.obolibrary.org/obo/HP_0009586		
UBERON:0022357	biolink:AnatomicalEntity	mesentery of ileum		FMA:14652	hp.json	ileal mesentery|ileum mesentery|mesoileum	http://purl.obolibrary.org/obo/UBERON_0022357		
HP:0009585	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the 2nd finger	Uneven (irregular) increase in bone density of the proximal phalanx of the second finger.	UMLS:C4024278	hp.json	Uneven increase in bone density in innermost index finger bone	http://purl.obolibrary.org/obo/HP_0009585		
HP:0046508	biolink:PhenotypicFeature	Abnormal cervical spine morphology	Any morphological abnormality of the cervical vertebral column.	SNOMED_CT:298391004	hp.json		http://purl.obolibrary.org/obo/HP_0046508		
UBERON:0022358	biolink:AnatomicalEntity	placenta blood vessel	A blood vessel of the placenta.	SCTID:280716005	hp.json	placental vessel	http://purl.obolibrary.org/obo/UBERON_0022358		
HP:0046504	biolink:PhenotypicFeature	Decreased libido	Decreased sexual desire.		hp.json		http://purl.obolibrary.org/obo/HP_0046504		
HP:0046505	biolink:PhenotypicFeature	Hand pain	An unpleasant sensation characterized by physical discomfort localized to the hand.		hp.json		http://purl.obolibrary.org/obo/HP_0046505		
UBERON:0010392	biolink:AnatomicalEntity	B cell domain			hp.json		http://purl.obolibrary.org/obo/UBERON_0010392		
HP:0046506	biolink:PhenotypicFeature	Pain in head and neck region			hp.json		http://purl.obolibrary.org/obo/HP_0046506		
CHEBI:76759	biolink:ChemicalSubstance	EC 3.* (hydrolase) inhibitor	Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*).	Wikipedia:Hydrolase	hp.json	hydrolase (EC 3.*) inhibitors|EC 3.* inhibitors|hydrolase (EC 3.*) inhibitor|EC 3.* inhibitor|EC 3.*.*.* inhibitors|EC 3.* (hydrolase) inhibitors|hydrolase inhibitors|hydrolase inhibitor|EC 3.*.*.* inhibitor	http://purl.obolibrary.org/obo/CHEBI_76759		3_STAR
HP:0046507	biolink:PhenotypicFeature	Bradypnea	Bradypnea is referring to breathing that is abnormally slow.	SNOMED_CT:86684002	hp.json		http://purl.obolibrary.org/obo/HP_0046507		
UBERON:0010390	biolink:AnatomicalEntity	lumen of urethra	An organ cavity that is part of a urethra.	FMA:19709	hp.json	urethral lumen	http://purl.obolibrary.org/obo/UBERON_0010390		
UBERON:0010395	biolink:AnatomicalEntity	lymph node primary follicle	An unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex.	FMA:312350|MA:0000743|EMAPA:35530	hp.json	primary follicle of lymph node	http://purl.obolibrary.org/obo/UBERON_0010395		pheno_slim|human_reference_atlas
HP:0010577	biolink:PhenotypicFeature	Absent epiphyses		UMLS:C4021862	hp.json	Absent end part of bone	http://purl.obolibrary.org/obo/HP_0010577		
HP:0010576	biolink:PhenotypicFeature	Intracranial cystic lesion	A cystic lesion originating within the brain.	UMLS:C4021250	hp.json	Cerebral cystic malformation	http://purl.obolibrary.org/obo/HP_0010576		
HP:0010575	biolink:PhenotypicFeature	Dysplasia of the femoral head	The presence of developmental dysplasia of the femoral head.	UMLS:C4280377|UMLS:C4021251	hp.json	Dysplastic femoral head|Abnormality of femoral head development	http://purl.obolibrary.org/obo/HP_0010575		
UBERON:0010393	biolink:AnatomicalEntity	T cell domain			hp.json		http://purl.obolibrary.org/obo/UBERON_0010393		
HP:0010574	biolink:PhenotypicFeature	Abnormality of the epiphysis of the femoral head	Any abnormality of the proximal epiphysis of the femur.	UMLS:C4021252	hp.json	Abnormality of the end part of the innermost thighbone|Abnormality of the proximal femoral epiphysis	http://purl.obolibrary.org/obo/HP_0010574		
UBERON:0010394	biolink:AnatomicalEntity	lymphocyte domain			hp.json		http://purl.obolibrary.org/obo/UBERON_0010394		
UBERON:0010399	biolink:AnatomicalEntity	spleen trabecular artery	One of the branches of the splenic artery[MP].	UMLS:C1710159|NCIT:C49775|MA:0000759	hp.json	trabecular artery	http://purl.obolibrary.org/obo/UBERON_0010399		pheno_slim|human_reference_atlas
CHEBI:64775	biolink:ChemicalSubstance	organic anionic group	An anionic group that contains carbon.		hp.json	organic anionic groups	http://purl.obolibrary.org/obo/CHEBI_64775		3_STAR
HP:0010571	biolink:PhenotypicFeature	Elevated levels of phytanic acid	An abnormal elevation of phytanic acid.	UMLS:C4023786	hp.json	Elevated levels of phytanic acid	http://purl.obolibrary.org/obo/HP_0010571		
HP:0010570	biolink:PhenotypicFeature	Low maternal circulating alpha-fetoprotein concentration	An abnormally low concentration of serum alpha-fetoprotein as compared to normal values for gestational-age.	UMLS:C4023787	hp.json	Low maternal serum alpha-fetoprotein	http://purl.obolibrary.org/obo/HP_0010570		
CHEBI:15734	biolink:ChemicalSubstance	primary alcohol	A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.	KEGG:C00226	hp.json	a primary alcohol|Primary alcohol|1-Alcohol|primary alcohols	http://purl.obolibrary.org/obo/CHEBI_15734		3_STAR
HP:0010579	biolink:PhenotypicFeature	Cone-shaped epiphysis	Cone-shaped epiphyses (also known as coned epiphyses) are epiphyses that invaginate into cupped metaphyses. That is, the epiphysis has a cone-shaped distal extension resulting from increased growth of the central portion of the epiphysis relative to its periphery.	UMLS:C1865037	hp.json	Cone-shaped epiphyses|Cone-shaped end part of bone|Coned epiphyses	http://purl.obolibrary.org/obo/HP_0010579		
UBERON:0022360	biolink:AnatomicalEntity	male mammary gland duct	A mammary gland duct that is part of a male organism. This structure typically regresses.		hp.json		http://purl.obolibrary.org/obo/UBERON_0022360		
HP:0010578	biolink:PhenotypicFeature	Bracket epiphyses		UMLS:C4023785	hp.json	Bracket shaped end part of long bone	http://purl.obolibrary.org/obo/HP_0010578		
HP:0009599	biolink:PhenotypicFeature	Abnormality of thumb epiphysis	Abnormality of one or all of the epiphyses of the proximal, and distal phalanges of the thumb and/or the 1st metacarpal.	UMLS:C4021429	hp.json	Abnormality of the epiphyses of the thumb|Abnormality of end part of thumb long bone|Abnormality of thumb epiphyses	http://purl.obolibrary.org/obo/HP_0009599		
HP:0009598	biolink:PhenotypicFeature	Symphalangism of the proximal phalanx of the 2nd finger with the 2nd metacarpal	Fusion of the proximal phalanx of the 2nd finger with the 2nd metacarpal.	UMLS:C4024274	hp.json	Fused innermost bone of index finger with 2nd long bone of hand	http://purl.obolibrary.org/obo/HP_0009598		
UBERON:0022361	biolink:AnatomicalEntity	lung field	A specific region of the foregut into the area in which the lung will develop.	SCTID:34922002	hp.json	lung field	http://purl.obolibrary.org/obo/UBERON_0022361		
HP:0046502	biolink:PhenotypicFeature	Anorgasmia	Inability of individual to reach orgasm.		hp.json		http://purl.obolibrary.org/obo/HP_0046502		
HP:0046503	biolink:PhenotypicFeature	Increased libido	Elevated sexual desire.		hp.json		http://purl.obolibrary.org/obo/HP_0046503		
HP:0009595	biolink:PhenotypicFeature	Occasional neurofibromas	Neurofibromas present in a smaller number than usually seen in neurofibromatosis type 1.	UMLS:C3810474	hp.json		http://purl.obolibrary.org/obo/HP_0009595		
HP:0009594	biolink:PhenotypicFeature	Retinal hamartoma	A hamartoma (a benign, focal malformation consisting of a disorganized mixture of cells and tissues) of the retina.	UMLS:C1863411	hp.json		http://purl.obolibrary.org/obo/HP_0009594		
HP:0009597	biolink:PhenotypicFeature	Short proximal phalanx of the 2nd finger	Hypoplasia (congenital reduction in size) of the proximal phalanx of the second finger.	UMLS:C4021430	hp.json	Short proximal phalanx of the second finger|Hypoplastic/small proximal phalanx of the 2nd finger|Short proximal index finger phalanx	http://purl.obolibrary.org/obo/HP_0009597		
HP:0009596	biolink:PhenotypicFeature	Aplasia of the proximal phalanx of the 2nd finger	Absence of the proximal phalanx of the 2nd finger.	UMLS:C4024275	hp.json	Absent innermost bone of index finger	http://purl.obolibrary.org/obo/HP_0009596		
UBERON:0000978	biolink:AnatomicalEntity	leg	The portion of the hindlimb that contains both the stylopod and zeugopod.	MA:0000047|EHDAA2:0000972|GAID:49|BTO:0000721|MESH:D035002|EFO:0001411|CALOHA:TS-2206|VHOG:0000345|EHDAA:8289|EHDAA:6176|OpenCyc:Mx4rvViYzZwpEbGdrcN5Y29ycA|EHDAA:5151|EMAPA:17489	hp.json	lower extremity|tetrapod leg	http://purl.obolibrary.org/obo/UBERON_0000978		pheno_slim|efo_slim|uberon_slim
UBERON:0000979	biolink:AnatomicalEntity	tibia	The major preaxial endochondral bone in the posterior zeugopod[Phenoscape].	UMLS:C0040184|MA:0001361|EMAPA:19142|galen:Tibia|AAO:0000890|FMA:24476|BTO:0001252|GAID:204|CALOHA:TS-1048|EFO:0003054|OpenCyc:Mx4rvtq3-ZwpEbGdrcN5Y29ycA|NCIT:C12800|MESH:D013977	hp.json	shinbone|shankbone	http://purl.obolibrary.org/obo/UBERON_0000979		pheno_slim|efo_slim|uberon_slim
UBERON:0000974	biolink:AnatomicalEntity	neck	An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column.	AEO:0000108|FMA:7155|MAT:0000297|BTO:0000420|GAID:86|OpenCyc:Mx4rvVjLF5wpEbGdrcN5Y29ycA|EMAPA:35587|Wikipedia:Neck|UMLS:C0027530|NCIT:C13063|MIAA:0000297|SCTID:302550007|MESH:D009333|EFO:0000967|galen:Neck|EHDAA2:0003108|CALOHA:TS-2045|MA:0000024	hp.json	collum|neck (volume)|collum	http://purl.obolibrary.org/obo/UBERON_0000974		pheno_slim|efo_slim|uberon_slim
HGNC:1516	biolink:Gene	CAT (human)	A protein coding gene CAT in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=1516		
UBERON:0000975	biolink:AnatomicalEntity	sternum	A midventral endochondral skeletal element which represents the origin site of the pectoral muscles[PHENOSCAPE:ad].	MESH:D013249|EMAPA:18344|UMLS:C0038293|OpenCyc:Mx4rvVjO6JwpEbGdrcN5Y29ycA|AAO:0000765|MA:0001331|FMA:7485|VHOG:0000856|galen:Sternum|NCIT:C12793|BTO:0001302|CALOHA:TS-0972|EHDAA2:0001914|EHDAA:9561|GAID:246	hp.json	breastbone|vertebrate sternum	http://purl.obolibrary.org/obo/UBERON_0000975		pheno_slim|uberon_slim
UBERON:0000976	biolink:AnatomicalEntity	humerus	Paired endochondral long bone that extends between the pectoral girdle and the skeletal parts of the forelimb. [PHENOSCAPE:mah].	galen:Humerus|NCIT:C12731|XAO:0003210|MESH:D006811|GAID:183|EFO:0001398|FMA:13303|VHOG:0001158|UMLS:C0020164|CALOHA:TS-2202|EMAPA:19106|AAO:0000679|MA:0001356	hp.json	proximal metapterygial mesomere of pectoral appendage|humerus bone|mesomere 1 of pectoral appendage|proximal metapterygial mesomere of pectoral fin|humeri	http://purl.obolibrary.org/obo/UBERON_0000976		pheno_slim|efo_slim|uberon_slim
UBERON:0000977	biolink:AnatomicalEntity	pleura	The invaginated serous membrane that surrounds the lungs (the visceral portion) and lines the walls of the pleural cavity (parietal portion).	MESH:D010994|OpenCyc:Mx4rv3zwLZwpEbGdrcN5Y29ycA|GAID:360|SCTID:181609007|FMA:9583|UMLS:C0032225|EV:0100044|CALOHA:TS-2081|EFO:0001980|BTO:0001791|EMAPA:16775|VHOG:0000394|MA:0000433|Wikipedia:Pleura|NCIT:C12469	hp.json	pleural tissue|pleura|wall of pleural sac	http://purl.obolibrary.org/obo/UBERON_0000977		pheno_slim|efo_slim|uberon_slim
UBERON:0036925	biolink:AnatomicalEntity	wall of eyeball		FMA:58098	hp.json	eyeball wall	http://purl.obolibrary.org/obo/UBERON_0036925		
UBERON:0000981	biolink:AnatomicalEntity	femur	Endochondral longbone connecting the pelvic girdle with posterior zeugopodium skeleton.[VSAO, modified].	EMAPA:19143|MESH:D005269|OpenCyc:Mx4rvVjOJJwpEbGdrcN5Y29ycA|UMLS:C0015811|VHOG:0001159|NCIT:C12717|EFO:0001396|CALOHA:TS-0322|MA:0001359|VSAO:0000186|BTO:0001284|AAO:0000889|XAO:0003214|FMA:9611|galen:Femur|AAO:0000887|GAID:199	hp.json	mesomere 1 of pevlic appendage|os femoris|proximal metapterygial mesomere of pelvic fin|femoral bone|proximal metapterygial mesomere of pelvic appendage|thigh bone|os femorale|os longissimum	http://purl.obolibrary.org/obo/UBERON_0000981		pheno_slim|efo_slim|uberon_slim
UBERON:0000982	biolink:AnatomicalEntity	skeletal joint	Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO].	XAO:0000171|Wikipedia:Joint|MAT:0000188|BTO:0001686|MA:0000319|NCIT:C13044|RETIRED_EHDAA2:0003182|FMA:7490|SCTID:302536002|VSAO:0000101|MIAA:0000188|EMAPA:35456|MESH:D007596|EFO:0000948|VHOG:0001276|GAID:102|OpenCyc:Mx4rvVjjdpwpEbGdrcN5Y29ycA|CALOHA:TS-2023|UMLS:C0022417|AEO:0000182|TAO:0000367|ZFA:0001596|galen:Joint	hp.json	articular joint|articulation|joints|joint	http://purl.obolibrary.org/obo/UBERON_0000982		pheno_slim|efo_slim|uberon_slim|vertebrate_core|organ_slim
UBERON:0000983	biolink:AnatomicalEntity	metatarsus region	A metapodium region that is part of a pes.	FMA:24997|MA:0000049|CALOHA:TS-2221	hp.json	metatarsal part of foot|hindlimb equine cannon region|metatarsal region|hindlimb cannon region|hind metapodium|regio metatarsalis|metatarsus	http://purl.obolibrary.org/obo/UBERON_0000983		uberon_slim
UBERON:0000980	biolink:AnatomicalEntity	trochanter	A bony prominence near the extremity of the femur that normally serves as attachment points for hip and thigh muscles[MP,modified].	UMLS:C0162370|NCIT:C33814|MA:0002821|FMA:82513|AAO:0000897	hp.json	femoral trochanter|trochanter of femur	http://purl.obolibrary.org/obo/UBERON_0000980		pheno_slim|uberon_slim
UBERON:0000963	biolink:AnatomicalEntity	head sensillum		MAT:0000204|FBbt:00004114|MIAA:0000204	hp.json		http://purl.obolibrary.org/obo/UBERON_0000963		
UBERON:0000964	biolink:AnatomicalEntity	cornea	The transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure.	ZFA:0000640|GAID:892|MA:0000266|MESH:D003315|TAO:0000640|EHDAA:10199|AAO:0010344|CALOHA:TS-0171|EFO:0000377|Wikipedia:Cornea|NCIT:C12342|EMAPA:17161|EV:0100341|XAO:0000180|FMA:58238|BTO:0000286|SCTID:181162001|UMLS:C0010031|OpenCyc:Mx4rvViBa5wpEbGdrcN5Y29ycA|EHDAA2:0000316|VHOG:0000164	hp.json	cornea of camera-type eye|corneas|tunica cornea	http://purl.obolibrary.org/obo/UBERON_0000964		pheno_slim|human_reference_atlas|efo_slim|uberon_slim|vertebrate_core
UBERON:0000965	biolink:AnatomicalEntity	lens of camera-type eye	Transparent part of camera-type eye that helps to refract light to be focused on the retina.	AAO:0010348|ZFA:0000035|OpenCyc:Mx4rvVj0fZwpEbGdrcN5Y29ycA|FMA:58241|NCIT:C12743|MESH:A09.371.509|BTO:0000723|TAO:0000035|MA:0000275|UMLS:C0023317|Wikipedia:Lens_(anatomy)|EV:0100343|EMAPA:17838|MAT:0000141|RETIRED_EHDAA2:0000975|CALOHA:TS-0545|XAO:0000008|VHOG:0000169|EHDAA:9057|MESH:D007908|MIAA:0000141|SCTID:181169005	hp.json	lens|lens crystallina|lens crystallina|eye lens|crystalline lens|lenses|ocular lens|camera-type eye lens	http://purl.obolibrary.org/obo/UBERON_0000965		vertebrate_core|pheno_slim|human_reference_atlas|uberon_slim
UBERON:0000966	biolink:AnatomicalEntity	retina	The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.	UMLS:C1278894|Wikipedia:Retina|EHDAA:4757|EMAPA:17168|EV:0100348|BAMS:R|NIFSTD_RETIRED:birnlex_1156|UMLS:C0035298|BIRNLEX:1153|EFO:0000832|MA:0000276|MBA:304325711|VHOG:0000229|ZFA:0000152|UMLS:C0035298|SCTID:181171005|NCIT:C12343|OpenCyc:Mx4rvViTfpwpEbGdrcN5Y29ycA|TAO:0000152|AAO:0010352|XAO:0000009|MAT:0000142|CALOHA:TS-0865|GAID:755|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1862|FMA:58301|BTO:0001175|MIAA:0000142|MESH:D012160|EHDAA2:0001627	hp.json	tunica interna of eyeball|retinas|Netzhaut|retina of camera-type eye|inner layer of eyeball	http://purl.obolibrary.org/obo/UBERON_0000966		vertebrate_core|pheno_slim|human_reference_atlas|efo_slim|uberon_slim
CHEBI:37163	biolink:ChemicalSubstance	glucan	A polysaccharide composed of glucose residues.	KEGG:C01379|CAS:9037-91-6	hp.json	Glucan|glucans|glucan	http://purl.obolibrary.org/obo/CHEBI_37163		3_STAR
UBERON:0000970	biolink:AnatomicalEntity	eye	An organ that detects light.	GAID:69|BILA:0000017|OpenCyc:Mx4rvViTvpwpEbGdrcN5Y29ycA|FBbt:00005162|MESH:D005123|MAT:0000140|EFO:0000827|MIAA:0000140|Wikipedia:Eye|BTO:0000439|EV:0100336|CALOHA:TS-0309	hp.json	light-detecting organ|visual apparatus	http://purl.obolibrary.org/obo/UBERON_0000970		efo_slim|human_reference_atlas|uberon_slim|major_organ|functional_classification|organ_slim
CHEBI:37164	biolink:ChemicalSubstance	homopolysaccharide	Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'.		hp.json	homoglycan|homopolysaccharide|homopolysaccharides	http://purl.obolibrary.org/obo/CHEBI_37164		3_STAR
UBERON:0000971	biolink:AnatomicalEntity	ommatidium	The smallest morphological and functional unit of the compound eye that consists of a usually limited and often constant number of rhabdomeric photoreceptor cells, cornea-secreting epithelial cells, and interommatidial pigment cells, and may additionally contain crystalline cone cells.	Wikipedia:Ommatidium|MAT:0000143|MIAA:0000143|HAO:0000666|FBbt:00004510|BTO:0001922	hp.json	omatidia|omatidium	http://purl.obolibrary.org/obo/UBERON_0000971		uberon_slim
UBERON:0022302	biolink:AnatomicalEntity	short ciliary nerve	A branch of the ciliary ganglion that innervates the ciliary muscles, the iris, and the tunics of the eyeball.	FMA:7041	hp.json	short ciliary nerve|nervi ciliares breves|nervi ciliares brevis|lower branch of ciliary ganglion	http://purl.obolibrary.org/obo/UBERON_0022302		
UBERON:0000956	biolink:AnatomicalEntity	cerebral cortex	The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex.	MAT:0000108|EMAPA:17544|DHBA:10159|PBA:128011354|BAMS:C|Wikipedia:Cerebral_cortex|EFO:0000328|BIRNLEX:1494|UMLS:C0007776|BAMS:Cerebral_cortex|MIAA:0000108|BAMS:Cx|FMA:61830|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=39|EHDAA2:0000234|NCIT:C12443|MA:0000185|MBA:688|GAID:629|EV:0100166|SCTID:362880003|HBA:4008|VHOG:0000722|EHDAA:5464|BM:Tel-Cx|CALOHA:TS-0091|MESH:D002540|BTO:0000233|UMLS:C0007776|BAMS:CTX	hp.json	cortical plate (CTXpl)|cortical plate (areas)|cortex cerebri|cortex cerebri|pallium of the brain|cortex cerebralis|brain cortex|cortex of cerebral hemisphere	http://purl.obolibrary.org/obo/UBERON_0000956		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0022303	biolink:AnatomicalEntity	nervous system cell part layer	Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO].	NLX:149357	hp.json	lamina|layer	http://purl.obolibrary.org/obo/UBERON_0022303		cumbo
UBERON:0000957	biolink:AnatomicalEntity	lamina	Any thin layer or plate.	Wikipedia:Lamina_of_the_vertebral_arch	hp.json	laminar tissue	http://purl.obolibrary.org/obo/UBERON_0000957		uberon_slim|non_informative|upper_level
CHEBI:50114	biolink:ChemicalSubstance	estrogen	A hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals by binding to oestrogen receptors. The oestrogens are named for their importance in the oestrous cycle. The oestrogens that occur naturally in the body, notably estrone, estradiol, estriol, and estetrol are steroids. Other compounds with oestrogenic activity are produced by plants (phytoestrogens) and fungi (mycoestrogens); synthetic compounds with oestrogenic activity are known as xenoestrogens.	Wikipedia:Estrogen	hp.json	oestrogen|Oestrogen|estrogenes|oestrogenes|oestrogene|Oestrogene|Estrogene|estrogene|oestrogens|estrogens|estrogenes Hormon|estrogeno|estrogenos	http://purl.obolibrary.org/obo/CHEBI_50114		3_STAR
UBERON:0000958	biolink:AnatomicalEntity	medulla of organ	Middle part of an organ, surrounded by the cortex.	FMA:61108|galen:Medulla	hp.json	medulla	http://purl.obolibrary.org/obo/UBERON_0000958		upper_level
CHEBI:50113	biolink:ChemicalSubstance	androgen	A sex hormone that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors.		hp.json	androgenes|androgene|Androgene|androgens|androgeno|androgenos|Androgen	http://purl.obolibrary.org/obo/CHEBI_50113		3_STAR
UBERON:0000959	biolink:AnatomicalEntity	optic chiasma	A decussation of the diencephalon where the fibers of the optic nerve cross.	ZFA:0000556|DHBA:10644|UMLS:C0029126|EHDAA:10227|NCIT:C90609|BAMS:och|TAO:0000556|BAMS:ox|HBA:9310|AAO:0010622|EHDAA2:0001302|DMBA:17783|BAMS:OC|MBA:117|UMLS:C0029126|MA:0001098|VHOG:0000190|BIRNLEX:1416|FMA:62045|MESH:D009897|BAMS:DC|BM:Tel-OCX|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=459|EMAPA:17603|XAO:0004071|GAID:832	hp.json	chiasma opticum|chiasma|optic chiasm (Rufus of Ephesus)|optic chiasm|decussation of optic nerve fibers|chiasma nervorum opticorum	http://purl.obolibrary.org/obo/UBERON_0000959		uberon_slim|vertebrate_core|pheno_slim
UBERON:0000955	biolink:AnatomicalEntity	brain	The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].	FMA:50801|EMAPA:16894|MESH:D001921|MA:0000168|ABA:Brain|OpenCyc:Mx4rvVjT65wpEbGdrcN5Y29ycA|DHBA:10155|AAO:0010478|XAO:0000010|GAID:571|EHDAA:2641|MBA:8|CALOHA:TS-0095|MBA:997|EFO:0000302|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=21|SCTID:258335003|UMLS:C1269537|galen:Brain|BIRNLEX:796|BAMS:Br|MAT:0000098|UMLS:C0006104|BILA:0000135|EV:0100164|EHDAA:6485|HBA:4005|ZFA:0000008|VHOG:0000157|Wikipedia:Brain|EHDAA2:0000183|FBbt:00005095|BTO:0000142|PBA:3999|UMLS:C0006104|MIAA:0000098|BAMS:Brain|TAO:0000008|NCIT:C12439	hp.json	suprasegmental structures|encephalon|the brain|suprasegmental levels of nervous system|synganglion	http://purl.obolibrary.org/obo/UBERON_0000955		major_organ|vertebrate_core|pheno_slim|efo_slim|human_reference_atlas|cumbo|uberon_slim
UBERON:0000962	biolink:AnatomicalEntity	nerve of cervical vertebra	The cervical nerves are the spinal nerves from the cervical vertebrae. Although there are seven cervical vertebrae (C1-C7), there are eight cervical nerves (C1-C8). All nerves except C8 emerge above their corresponding vertebrae, while the C8 nerve emerges below the C7 vertebra. (In the other portions of the spine, the nerve emerges below the vertebra with the same name. Dorsal (posterior) distribution includes the greater occipital (C2) and third occipital (C3). Ventral (anterior) distribution includes the cervical plexus (C1-C4) and brachial plexus (C5-C8) [WP,unvetted].	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2351|NCIT:C32299|Wikipedia:Cervical_nerves|SCTID:360497008|FMA:5859|BAMS:cern|UMLS:C0228815|NLXANAT:20090207	hp.json	cervical spinal nerve|nervus cervicalis|cervical nerve tree|cervical nerve	http://purl.obolibrary.org/obo/UBERON_0000962		uberon_slim
CHEBI:50112	biolink:ChemicalSubstance	sex hormone	Any hormone that is responsible for controlling sexual characteristics and reproductive function.		hp.json	Sexualhormon|hormone sexuelle|Sexualhormone|sex hormones|Geschlechtshormon|hormones sexuelles|Geschlechtshormone	http://purl.obolibrary.org/obo/CHEBI_50112		3_STAR
UBERON:0000945	biolink:AnatomicalEntity	stomach	An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium.	NCIT:C12391|MESH:D013270|ANISEED:1235297|EFO:0000837|EV:0100070|UMLS:C0038351|CALOHA:TS-0980|MIAA:0000051|SCTID:181246003|FMA:7148|AAO:0000579|BTO:0001307|VHOG:0000408|MA:0000353|EHDAA:2993|EMAPA:17021|galen:Stomach|GAID:293|TAO:0002121|Wikipedia:Stomach|EHDAA2:0001915|XAO:0000128|OpenCyc:Mx4rvVjlqpwpEbGdrcN5Y29ycA|MAT:0000051	hp.json	ventriculus|anterior intestine|stomach chamber|gaster|ventriculus|mesenteron	http://purl.obolibrary.org/obo/UBERON_0000945		uberon_slim|major_organ|vertebrate_core|organ_slim|pheno_slim|efo_slim
UBERON:0000946	biolink:AnatomicalEntity	cardial valve	A membranous fold of the heart that prevents reflux of fluid.	TAO:0005065|MESH:D006351|VHOG:0000818|XAO:0004126|GAID:176|FMA:7110|galen:HeartValve|EV:0100024|MA:0000086|UMLS:C0018826|BTO:0000564|EMAPA:17869|ZFA:0005065|NCIT:C12729|OpenCyc:Mx4rv8oyuJwpEbGdrcN5Y29ycA	hp.json	cardiac valve|stomodaeal valve|valve of heart|heart valves|heart valve|heart valve|valvule	http://purl.obolibrary.org/obo/UBERON_0000946		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas
UBERON:0000947	biolink:AnatomicalEntity	aorta	The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation.	galen:Aorta|GAID:469|CALOHA:TS-0046|EMAPA:18601|NCIT:C12669|SCTID:181298001|Wikipedia:Aorta|EV:0100027|OpenCyc:Mx4rvVjvTpwpEbGdrcN5Y29ycA|AAO:0010213|XAO:0003010|MAT:0000035|UMLS:C0003483|BTO:0000135|MA:0000062|MESH:D001011|EFO:0000265|VHOG:0001523|FMA:3734|MIAA:0000035	hp.json	trunk of systemic arterial tree|dorsal aorta|dorsal aorta|arteria maxima|trunk of aortic tree|arteria maxima	http://purl.obolibrary.org/obo/UBERON_0000947		uberon_slim|grouping_class|pheno_slim|efo_slim|human_reference_atlas
CHEBI:50103	biolink:ChemicalSubstance	excitatory amino acid agonist	An agent that binds to and activates excitatory amino acid receptors.		hp.json	excitatory amino acid receptor agonist|excitatory amino acid receptor agonists|excitatory amino acid agonists	http://purl.obolibrary.org/obo/CHEBI_50103		3_STAR
UBERON:0000948	biolink:AnatomicalEntity	heart	A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ.	MESH:D006321|EHDAA2:0000738|Wikipedia:Heart|CALOHA:TS-0445|NCIT:C12727|VHOG:0000276|EMAPA:16105|EFO:0000815|SCTID:302509004|BILA:0000020|ZFA:0000114|EV:0100018|TAO:0000114|XAO:0000064|OpenCyc:Mx4rvVjvDpwpEbGdrcN5Y29ycA|GAID:174|EHDAA:420|MAT:0000036|FMA:7088|AAO:0010210|galen:Heart|UMLS:C0018787|MIAA:0000036|MA:0000072|BTO:0000562	hp.json	vertebrate heart|cardium|branchial heart|chambered heart|chambered heart	http://purl.obolibrary.org/obo/UBERON_0000948		uberon_slim|vertebrate_core|major_organ|organ_slim|pheno_slim|efo_slim|human_reference_atlas
UBERON:0000941	biolink:AnatomicalEntity	cranial nerve II	Cranial nerve fiber tract which is comprised of retinal ganglion cell axons running posterior medially towards the optic chiasm, at which some of the axons cross the midline and after which the structure is termed the optic tract. Transmits visual information from the retina to the brain[ZFA].	BIRNLEX:1640|TAO:0000435|MBA:848|EMAPA:17575|XAO:0000188|OpenCyc:Mx4rvVjLm5wpEbGdrcN5Y29ycA|UMLS:C0029130|EHDAA2:0001313|DHBA:15544|EHDAA:6788|AAO:0010345|FMA:50863|BAMS:IIn|BAMS:nII|NCIT:C12761|MA:0001097|MESH:D009900|CALOHA:TS-0713|EFO:0004258|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=289|VHOG:0000543|HBA:9307|ZFA:0000435|BAMS:2n|GAID:831|UMLS:C0029130	hp.json	02 optic nerve|CN-II|nerve II|nervus opticus [II]|optic|optic nerve [II]|optic II|optic nerve|nervus opticus|cranial II|second cranial nerve|2n|optic II nerve	http://purl.obolibrary.org/obo/UBERON_0000941		vertebrate_core|pheno_slim|efo_slim|uberon_slim
UBERON:0000949	biolink:AnatomicalEntity	endocrine system	Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity.	NCIT:C12705|CALOHA:TS-1301|SCTID:278876000|XAO:0000158|VHOG:0000098|FMA:9668|ZFA:0001158|EFO:0002969|MESH:D004703|EV:0100128|MA:0000012|TAO:0001158|AAO:0010279|EHDAA2:0002224|FBbt:00005068|EMAPA:35306|GAID:439|Wikipedia:Endocrine_system|UMLS:C0014136	hp.json	endocrine system|endocrine glandular system|systema endocrinum	http://purl.obolibrary.org/obo/UBERON_0000949		uberon_slim|vertebrate_core|pheno_slim|efo_slim
GO:1904588	biolink:BiologicalProcess	cellular response to glycoprotein	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.		hp.json	cellular response to glycoproteins	http://purl.obolibrary.org/obo/GO_1904588		
GO:1904587	biolink:BiologicalProcess	response to glycoprotein	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycoprotein stimulus.		hp.json	response to glycoproteins	http://purl.obolibrary.org/obo/GO_1904587		
CHEBI:37142	biolink:ChemicalSubstance	organoiodine compound	An organoiodine compound is a compound containing at least one carbon-iodine bond.	MetaCyc:Organoiodine-Compounds|Wikipedia:Organoiodine_compound	hp.json	organoiodine compound|organoiodine compounds	http://purl.obolibrary.org/obo/CHEBI_37142		3_STAR
UBERON:0000951	biolink:AnatomicalEntity	rotator muscle of the vertebral column	Any of a number of short transversospinal muscles chiefly developed in cervical, lumbar, and thoracic regions, arising from the transverse process of one vertebra and inserted into the root of the spinous process of the next two or three vertebrae above, with nerve supply from the dorsal branches of the spinal nerve, and whose actions rotate the vertebral column.	FMA:23081	hp.json	rotator muscle	http://purl.obolibrary.org/obo/UBERON_0000951		
HP:0010522	biolink:PhenotypicFeature	Dyslexia	A learning disorder characterized primarily by difficulties in learning to read and spell. Dyslectic children also exhibit a tendency to read words from right to left and to confuse letters such as b and d whose orientation is important for their identification. Children with dyslexia appear to be impaired in phonemic skills (the ability to associate visual symbols with the sounds they represent).	MSH:D004410|UMLS:C0476254|SNOMEDCT_US:9236007|SNOMEDCT_US:52824009|SNOMEDCT_US:59770006	hp.json	Reading disability	http://purl.obolibrary.org/obo/HP_0010522		
HP:0010521	biolink:PhenotypicFeature	Gait apraxia	Gait apraxia affecting the ability to make walking movements with the legs.	UMLS:C1510417|MSH:D020235|SNOMEDCT_US:30767006	hp.json		http://purl.obolibrary.org/obo/HP_0010521		
UBERON:0010341	biolink:AnatomicalEntity	1st arch mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mesenchyme.	EMAPA:16130	hp.json	mesenchyme derived from head mesoderm of mesenchyme of 1st arch	http://purl.obolibrary.org/obo/UBERON_0010341		
NCBITaxon:337687	biolink:OrganismalEntity	Muroidea		PMID:15371245|PMID:15019624|GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_337687		
UBERON:0010344	biolink:AnatomicalEntity	3rd arch mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 3rd arch mesenchyme.	EMAPA:16403|EHDAA2:0000082	hp.json	head mesenchyme derived arch 3 mesenchyme|mesenchyme derived from head mesoderm of mesenchyme of 3rd arch|pharyngeal arch 3 mesenchyme from head mesenchyme|branchial arch 3 mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010344		
UBERON:0010345	biolink:AnatomicalEntity	4th arch mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 4th arch mesenchyme.	EHDAA2:0000097|EMAPA:16771	hp.json	head mesenchyme derived arch 4 mesenchyme|mesenchyme derived from head mesoderm of mesenchyme of 4th arch|pharyngeal arch 4 mesenchyme from head mesenchyme|branchial arch 4 mesenchyme from head mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010345		
UBERON:0010343	biolink:AnatomicalEntity	2nd arch mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 2nd arch mesenchyme.	EHDAA2:0000067|EMAPA:16280	hp.json	head mesenchyme derived arch 2 mesenchyme|branchial arch 2 mesenchyme from head mesenchyme|pharyngeal arch 2 mesenchyme from head mesenchyme|mesenchyme derived from head mesoderm of mesenchyme of 2nd arch	http://purl.obolibrary.org/obo/UBERON_0010343		
UBERON:0010337	biolink:AnatomicalEntity	mandibular process mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a mandibular process mesenchyme.	EHDAA2:0004604	hp.json		http://purl.obolibrary.org/obo/UBERON_0010337		
HP:0010529	biolink:PhenotypicFeature	Echolalia	The tendency to repeat vocalizations made by another person.	SNOMEDCT_US:64712007|UMLS:C0013528|UMLS:C4280380|MSH:D004454	hp.json	Repeated speech|Echologia|Echoing another person's speech|Echophrasia	http://purl.obolibrary.org/obo/HP_0010529		
UBERON:0010338	biolink:AnatomicalEntity	1st arch maxillary mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch maxillary mesenchyme.	EHDAA2:0000043	hp.json		http://purl.obolibrary.org/obo/UBERON_0010338		
HP:0009529	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4024307	hp.json	Irregular end part of innermost long bone of index finger	http://purl.obolibrary.org/obo/HP_0009529		
UBERON:0010335	biolink:AnatomicalEntity	maxillary process mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a maxillary process mesenchyme.	EHDAA2:0004602	hp.json		http://purl.obolibrary.org/obo/UBERON_0010335		
HP:0010528	biolink:PhenotypicFeature	Prosopagnosia	Inability to recognize faces of familiar persons.	UMLS:C0234512|SNOMEDCT_US:18358003|MSH:D020238	hp.json	Face blindness|Facial agnosia	http://purl.obolibrary.org/obo/HP_0010528		
UBERON:0010336	biolink:AnatomicalEntity	mandibular process mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a mandibular process mesenchyme.	EHDAA2:0004603	hp.json		http://purl.obolibrary.org/obo/UBERON_0010336		
HP:0010527	biolink:PhenotypicFeature	Astereognosia	Inability to recognize the form of objects by touch without visual input. That is, an impairment in the recognition of objects based only on the texture, size, weight and three-dimensional form of the object in the absence of any major somatosensory deficit.	MSH:D000377|UMLS:C0234505|SNOMEDCT_US:25094008	hp.json	Astereognosis|Somatosensory agnosia	http://purl.obolibrary.org/obo/HP_0010527		
HP:0009526	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4021456	hp.json	Cone-shaped end part of innermost long bone of index finger|Cone-shaped epiphysis of proximal index finger phalanx	http://purl.obolibrary.org/obo/HP_0009526		
HP:0010526	biolink:PhenotypicFeature	Dysgraphia	A writing disability in the absence of motor or sensory deficits of the upper extremities, resulting in an impairment in the ability to write regardless of the ability to read and not due to intellectual impairment.	MSH:D000381|UMLS:C0234144|SNOMEDCT_US:88278002	hp.json		http://purl.obolibrary.org/obo/HP_0010526		
HP:0010525	biolink:PhenotypicFeature	Finger agnosia	An inability or difficulty differentiating among the fingers of either hand as well as the hands of others.	MSH:D000377|SNOMEDCT_US:3449007|UMLS:C0234509	hp.json		http://purl.obolibrary.org/obo/HP_0010525		
HP:0009525	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the 2nd finger	An abnormality of the proximal phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4021457	hp.json	Bracket epiphyses of proximal index finger phalanx|Bracket shaped end part of innermost long bone of index finger	http://purl.obolibrary.org/obo/HP_0009525		
HP:0010524	biolink:PhenotypicFeature	Agnosia	Inability to recognize objects not because of sensory deficit but because of the inability to combine components of sensory impressions into a complete pattern. Thus, agnosia is a neurological condition which results in an inability to know, to name, to identify, and to extract meaning from visual, auditory, or tactile impressions.	MSH:D000377|SNOMEDCT_US:42341009|UMLS:C0001816	hp.json		http://purl.obolibrary.org/obo/HP_0010524		
UBERON:0010339	biolink:AnatomicalEntity	1st arch mandibular mesenchyme from head mesenchyme	Mesenchyme that develops_from a head mesenchyme from mesoderm and is part of a 1st arch mandibular mesenchyme.	EHDAA2:0000036	hp.json		http://purl.obolibrary.org/obo/UBERON_0010339		
HP:0009528	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4024308	hp.json	Fragmentation of end part of innermost long bone of index finger	http://purl.obolibrary.org/obo/HP_0009528		
HP:0010523	biolink:PhenotypicFeature	Alexia	An acquired type of sensory aphasia where damage to the brain leads to the loss of the ability to read.	UMLS:C0002018|MSH:D004410|SNOMEDCT_US:9236007	hp.json	Text blindness|Word blindness	http://purl.obolibrary.org/obo/HP_0010523		
HP:0009527	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4021455	hp.json	Large epiphysis of proximal index finger phalanx|Enlarged end part of innermost long bone of index finger	http://purl.obolibrary.org/obo/HP_0009527		
HP:0009522	biolink:PhenotypicFeature	Stippling of the epiphysis of the middle phalanx of the 2nd finger		UMLS:C4024311	hp.json	Speckled calcifications in end part of the middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0009522		
HP:0009521	biolink:PhenotypicFeature	Small epiphysis of the middle phalanx of the 2nd finger		UMLS:C4024312	hp.json	Small end part of the innermost long bone of index finger	http://purl.obolibrary.org/obo/HP_0009521		
HP:0009524	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4024309	hp.json	Absent end part of innermost long bone of index finger	http://purl.obolibrary.org/obo/HP_0009524		
HP:0009523	biolink:PhenotypicFeature	Triangular epiphysis of the middle phalanx of the 2nd finger		UMLS:C4024310	hp.json	Triangular end part of the middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0009523		
HP:0009520	biolink:PhenotypicFeature	Pseudoepiphysis of the middle phalanx of the 2nd finger	A secondary ossification center in the middle phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024313	hp.json		http://purl.obolibrary.org/obo/HP_0009520		
CHEBI:25147	biolink:ChemicalSubstance	mandelate		Beilstein:3905858|Gmelin:328159|CAS:769-61-9|Beilstein:4135334	hp.json	mandelate ion|2-hydroxy-2-(4-hydroxyphenyl)acetate|alpha-hydroxybenzeneacetic acid, ion(1-)|alpha-hydroxybenzeneacetate|mandelate|hydroxy(phenyl)acetate	http://purl.obolibrary.org/obo/CHEBI_25147		3_STAR
HP:0010511	biolink:PhenotypicFeature	Long toe	Toes that appear disproportionately long compared to the foot.	UMLS:C3150613	hp.json	Increased length of toes|Long toe|Long toes	http://purl.obolibrary.org/obo/HP_0010511		hposlim_core
UBERON:0010330	biolink:AnatomicalEntity	eyelid mesenchyme	Mesenchyme that is part of a developing eyelid.	EMAPA:32759	hp.json		http://purl.obolibrary.org/obo/UBERON_0010330		
HP:0010510	biolink:PhenotypicFeature	Hypermobility of toe joints	An ability of the toe joints to move beyond their normal range of motion.	UMLS:C4023798	hp.json		http://purl.obolibrary.org/obo/HP_0010510		
UBERON:0010333	biolink:AnatomicalEntity	extraembryonic membrane mesenchyme	Mesenchyme that is part of a extraembryonic membrane.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010333		
UBERON:0010334	biolink:AnatomicalEntity	maxillary process mesenchyme from neural crest	Mesenchyme that develops_from a neural crest and is part of a maxillary process mesenchyme.	EHDAA2:0004601	hp.json		http://purl.obolibrary.org/obo/UBERON_0010334		
UBERON:0010332	biolink:AnatomicalEntity	epithelium of handplate	An epithelium that is part of a handplate.	EMAPA:32630|EHDAA2:0000730	hp.json	handplate epithelium	http://purl.obolibrary.org/obo/UBERON_0010332		
HP:0010519	biolink:PhenotypicFeature	Increased fetal movement	An abnormal increase in quantity or strength of fetal movements.	UMLS:C4021256	hp.json	Increased foetal movement|Fetal hyperkinesia|Foetal hyperkinesia	http://purl.obolibrary.org/obo/HP_0010519		
HP:0010518	biolink:PhenotypicFeature	Thyroglossal cyst	An abnormality of the thyroid gland owing to the presence of a fibrous cyst resulting from the persistence of the thyroglossal duct.	MSH:D013955|SNOMEDCT_US:39462005|UMLS:C0040124	hp.json	Thyroglossal duct cyst	http://purl.obolibrary.org/obo/HP_0010518		hposlim_core
HP:0010517	biolink:PhenotypicFeature	Ectopic thymus tissue	The presence of ectopic thymus tissue. Normally, cells of the ventral bud of the third pharyngeal pouch detach and migrate in the eighth gestational week caudally and medially towards the location of the mature thyroid. They migrate further retrosternally into the superior mediastinum. There are two main ways ectopic thymus tissue can develop. Either cells detach along the descensus path and proliferate, thereby forming accessory thymus tissue, or the entire gland fails to descend.	UMLS:C4023795	hp.json	Abnormal thymus position	http://purl.obolibrary.org/obo/HP_0010517		
HP:0010516	biolink:PhenotypicFeature	Thymus hyperplasia	Enlargement of the thymus.	UMLS:C0040115|MSH:D013952	hp.json	Thymic hyperplasia|Enlarged thymus	http://purl.obolibrary.org/obo/HP_0010516		
HP:0009537	biolink:PhenotypicFeature	Flexion contracture of the 2nd finger	Chronic loss of joint motion in the 2nd finger due to structural changes in non-bony tissue. The term camptodactyly of the 2nd finger is used if the distal and/or proximal interphalangeal joints are affected.	UMLS:C4021452	hp.json	Joint contractures of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009537		
HP:0010515	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the thymus	Absence or underdevelopment of the thymus.	UMLS:C4023796|UMLS:C3278004	hp.json	Thymic hypoplasia or aplasia|Absent/small thymus|Absent/underdeveloped thymus	http://purl.obolibrary.org/obo/HP_0010515		
HP:0009536	biolink:PhenotypicFeature	Short 2nd finger	Hypoplasia of the second finger, also known as the index finger.	UMLS:C1862142	hp.json	Short index finger|Short index finger phalanges|Hypoplastic/small index finger|Short index fingers|Hypoplastic index finger phalanges	http://purl.obolibrary.org/obo/HP_0009536		
HP:0010514	biolink:PhenotypicFeature	Hyperpituitarism	Hypersecretion of one or more pituitary hormones. This can occur in conditions in which deficiency in the target organ leads to decreased hormonal feedback, or as a primary condition most usually in connection with a pituitary adenoma.	MSH:D006964|SNOMEDCT_US:10649000|UMLS:C0020506	hp.json		http://purl.obolibrary.org/obo/HP_0010514		
HP:0010513	biolink:PhenotypicFeature	Pituitary calcification	Deposition of calcium salts in the pituitary gland.	UMLS:C4023797	hp.json		http://purl.obolibrary.org/obo/HP_0010513		
HP:0009539	biolink:PhenotypicFeature	Contracture of the metacarpophalangeal joint of the 2nd finger	Chronic loss of joint motion of the metacarpophalangeal joint of the 2nd finger due to structural changes in non-bony tissue.	UMLS:C4024301	hp.json		http://purl.obolibrary.org/obo/HP_0009539		
UBERON:0010328	biolink:AnatomicalEntity	limb bud mesenchyme	Mesenchyme that is part of a limb bud.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010328		
HP:0009538	biolink:PhenotypicFeature	Contracture of the distal interphalangeal joint of the 2nd finger	Chronic loss of joint motion of the distal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue.	UMLS:C4024302	hp.json		http://purl.obolibrary.org/obo/HP_0009538		
HP:0010512	biolink:PhenotypicFeature	Adrenal calcification	Calcification within the adrenal glands.	UMLS:C0271750|SNOMEDCT_US:12286000	hp.json		http://purl.obolibrary.org/obo/HP_0010512		
UBERON:0010329	biolink:AnatomicalEntity	paired limb/fin bud mesenchyme	Mesenchyme that is part of a limb/fin bud.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010329		
HP:0009533	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4024303	hp.json	Speckled calcifications in end part of the innermost long bone of index finger	http://purl.obolibrary.org/obo/HP_0009533		
CHEBI:15792	biolink:ChemicalSubstance	malonate(2-)	A dicarboxylic acid dianion obtained by the deprotonation of the carboxy groups of malonic acid.	DrugBank:DB02201|PDBeChem:MLI|CAS:156-80-9|Gmelin:141932|Reaxys:3904386|Beilstein:3904386|KEGG:C00383	hp.json	malonic acid, ion(2-)|propanedioic acid, ion(2-)|(-)OOC-CH2-COO(-)|propanedioate|malonate|malo|MALONATE ION	http://purl.obolibrary.org/obo/CHEBI_15792		3_STAR
HP:0009532	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4024304	hp.json	Small end part of proximal long bond of index finger	http://purl.obolibrary.org/obo/HP_0009532		
HP:0009535	biolink:PhenotypicFeature	Aplasia of the 2nd finger	Absent 2nd (index) finger.	UMLS:C4021453	hp.json	Absent index finger|Aplasia of the index finger|Absent index finger phalanges	http://purl.obolibrary.org/obo/HP_0009535		
HP:0009534	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4021454	hp.json	Triangular end part of innermost long bone of index finger|Triangular epiphysis of proximal index finger phalanx	http://purl.obolibrary.org/obo/HP_0009534		
HP:0009531	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the 2nd finger	A secondary ossification center in the proximal phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024305	hp.json		http://purl.obolibrary.org/obo/HP_0009531		
HP:0009530	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4024306	hp.json	Increased bone density of end part of the innermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009530		
UBERON:0000996	biolink:AnatomicalEntity	vagina	A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP].	MA:0000394|GAID:381|UMLS:C0042232|FMA:19949|VHOG:0001138|BTO:0000243|CALOHA:TS-1103|NCIT:C12407|EMAPA:18986|galen:Vagina|MAT:0000128|EV:0100117|EFO:0000976|OpenCyc:Mx4rvVj1B5wpEbGdrcN5Y29ycA|MIAA:0000128|MESH:D014621	hp.json	vaginae|distal oviductal region|distal portion of oviduct	http://purl.obolibrary.org/obo/UBERON_0000996		pheno_slim|efo_slim|uberon_slim
UBERON:0000997	biolink:AnatomicalEntity	mammalian vulva	External genital organs of the female mammal[WP].	MA:0000395|galen:Vulva|GAID:383|VHOG:0001458|MIAA:0000169|BTO:0003101|FMA:20462|NCIT:C12408|EMAPA:36631|CALOHA:TS-1168|EV:0100118|OpenCyc:Mx4rvgAWeJwpEbGdrcN5Y29ycA|EFO:0000978|MESH:D014844|MAT:0000169|UMLS:C0042993	hp.json	pudendum muliebre|pudendum femininum|pudendum femininum|puboperineal region|vulva|mammalian vulva|pudendum|female pudendum	http://purl.obolibrary.org/obo/UBERON_0000997		pheno_slim|efo_slim|uberon_slim
UBERON:0000998	biolink:AnatomicalEntity	seminal vesicle	Either of a pair of glandular pouches that lie one on either side of the male reproductive tract posterolateral to the urinary bladder and in the human male secrete a sugar- and protein-containing fluid into the ejaculatory duct.	FMA:19386|GAID:394|OpenCyc:Mx4rwTtRpJwpEbGdrcN5Y29ycA|BTO:0001234|VHOG:0001379|UMLS:C0036628|MAT:0000171|EMAPA:19180|MESH:D012669|CALOHA:TS-0919|MA:0000410|AAO:0010788|EV:0100106|MIAA:0000171|NCIT:C12787|EFO:0000986	hp.json	vesiculae seminales|vesicular gland|vesicula seminalis|glandula vesiculosa|glandula seminalis|vesiculae seminales|vesicula seminalis|gonecyst|seminal gland|vesicular glands|vesicular seminalis|vas efferens|vesiculæ seminales	http://purl.obolibrary.org/obo/UBERON_0000998		pheno_slim|efo_slim|uberon_slim|organ_slim
UBERON:0000999	biolink:AnatomicalEntity	ejaculatory duct	The Ejaculatory ducts (ductus ejaculatorii) are paired structures in male anatomy, about 2 cm in length. Each ejaculatory duct is formed by the union of the vas deferens with the duct of the seminal vesicle. They pass through the prostate, and empty into the urethra at the Colliculus seminalis. During ejaculation, semen passes through the ducts and exits the body via the penis[WP,unvetted].	EFO:0000985|OpenCyc:Mx4rwOt7MJwpEbGdrcN5Y29ycA|EMAPA:19088|MESH:D004543|NCIT:C32493|UMLS:C0013747|MAT:0000170|CALOHA:TS-0211|BTO:0001580|FMA:19325|GAID:388|MIAA:0000170|MA:0003247	hp.json	ductus ejaculatorius|ductus ejaculatorii|ductus ejaculatorii	http://purl.obolibrary.org/obo/UBERON_0000999		efo_slim|uberon_slim
HP:0010500	biolink:PhenotypicFeature	Hyperextensibility of the knee	The ability of the knee joint to extend beyond its normal range of motion (the lower leg is moved beyond a straight position with respect to the thigh).	UMLS:C4023802	hp.json		http://purl.obolibrary.org/obo/HP_0010500		
UBERON:0010323	biolink:AnatomicalEntity	cranial skeletal system	Skeletal subdivision of the head including skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.	AAO:0000971|XAO:0003075|ZFA:0000737|VSAO:0000049|AAO:0010185|TAO:0000737|AAO:0000109	hp.json	cranium|osteocranium|cranial skeleton	http://purl.obolibrary.org/obo/UBERON_0010323		
UBERON:0010321	biolink:AnatomicalEntity	skeletal element of eye region	A skeletal element that is part of a orbital region.		hp.json	skeletal element of orbital region|eye skeleton|ocular skeleton	http://purl.obolibrary.org/obo/UBERON_0010321		
CHEBI:350546	biolink:ChemicalSubstance	serotonin(1+)	An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3.		hp.json	serotonin cation|serotonin|2-(5-hydroxy-1H-indol-3-yl)ethanaminium	http://purl.obolibrary.org/obo/CHEBI_350546		3_STAR
HP:0009508	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the 2nd finger	Sclerosis of the epiphysis of the distal phalanx of the 2nd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4021460	hp.json	Ivory epiphysis of terminal index finger phalanx|Increased bone density of end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009508		
HP:0010508	biolink:PhenotypicFeature	Metatarsus valgus	A condition in which the anterior part of the foot rotates outward away from the midline of the body and the heel remains straight.	UMLS:C4082144|MSH:D000070591	hp.json		http://purl.obolibrary.org/obo/HP_0010508		
HP:0009507	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the 2nd finger	Irregular radiographic opacity of the epiphysis of the distal phalanx of the 2nd finger.	UMLS:C4024323	hp.json	Irregular end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009507		
UBERON:0010316	biolink:AnatomicalEntity	germ layer / neural crest			hp.json		http://purl.obolibrary.org/obo/UBERON_0010316		
HP:0010507	biolink:PhenotypicFeature	Foot asymmetry	A difference in size or shape between the left and right foot.	UMLS:C4023799	hp.json		http://purl.obolibrary.org/obo/HP_0010507		
UBERON:0010313	biolink:AnatomicalEntity	neural crest-derived structure	An anatomical structure that develops from the neural crest.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010313		grouping_class
HP:0010506	biolink:PhenotypicFeature	Abnormal plantar dermatoglyphics	An abnormality of dermatoglyphs on the toes and soles, i.e., an abnormality of the patterns of ridges of the skin of sole of foot.	UMLS:C4021258	hp.json	Abnormal prints on feet|Abnormal dermatoglyphics on feet	http://purl.obolibrary.org/obo/HP_0010506		
HP:0009509	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the 2nd finger	A secondary ossification center in the distal phalanx of the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024322	hp.json		http://purl.obolibrary.org/obo/HP_0009509		
UBERON:0010314	biolink:AnatomicalEntity	structure with developmental contribution from neural crest	An anatomical structure that has some part that develops from the neural crest.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010314		grouping_class
HP:0010505	biolink:PhenotypicFeature	Limitation of movement at ankles	An abnormal limitation of the mobility of the ankle joint.	UMLS:C4023800	hp.json		http://purl.obolibrary.org/obo/HP_0010505		
HP:0009504	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the 2nd finger	A cone-shaped appearance of the epiphysis of the distal phalanx of the 2nd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4024326	hp.json	Cone-shaped end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009504		
HP:0010504	biolink:PhenotypicFeature	Increased length of the tibia	An abnormal increase in the length of the tibia.	UMLS:C4021864	hp.json	Increased length of shinbone|Increased length of shankbone	http://purl.obolibrary.org/obo/HP_0010504		
HP:0009503	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the 2nd finger	An abnormality of the distal phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024327	hp.json	Bracket shaped end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009503		
HP:0010503	biolink:PhenotypicFeature	Fibular duplication	Duplication of the fibula. This may occur as a part of diplopodia (accessory tarsal or metatarsal bone). Diplopodia with double fibula is an extremely rare condition.	UMLS:C3276742	hp.json	Duplicated calf bone	http://purl.obolibrary.org/obo/HP_0010503		hposlim_core
HP:0009506	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the 2nd finger	Fragmented appearance of the epiphysis of the distal phalanx of the 2nd finger.	UMLS:C4024324	hp.json	Fragmentation of end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009506		
HP:0010502	biolink:PhenotypicFeature	Fibular bowing	A bending or abnormal curvature of the fibula.	UMLS:C4023801	hp.json	Bowed calf bone	http://purl.obolibrary.org/obo/HP_0010502		
HP:0009505	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the 2nd finger	Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger with respect to age-dependent norms.	UMLS:C4024325	hp.json	Enlarged end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009505		
HP:0010501	biolink:PhenotypicFeature	Limitation of knee mobility	An abnormal limitation of knee joint mobility.	UMLS:C4021259	hp.json	Limited knee movement|Limitation of knee mobility	http://purl.obolibrary.org/obo/HP_0010501		
HP:0009500	biolink:PhenotypicFeature	Abnormality of the epiphysis of the middle phalanx of the 2nd finger		UMLS:C4021463	hp.json	Abnormality of end part of the middle bone of the index finger|Epiphyseal abnormality of middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009500		
HP:0009502	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the 2nd finger	Absence of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger.	UMLS:C4021461	hp.json	Absent end part of the outermost bone of the index finger|Absent ossification/absent epiphysis of terminal index finger phalanx	http://purl.obolibrary.org/obo/HP_0009502		
HP:0009501	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the 2nd finger		UMLS:C4021462	hp.json	Epiphyseal abnormality of the proximal phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009501		
HP:0010509	biolink:PhenotypicFeature	Aplasia of the tarsal bones	Absence of the tarsal bones.	UMLS:C4021257	hp.json	Absent tarsals|Absent ankle bone	http://purl.obolibrary.org/obo/HP_0010509		
UBERON:0000989	biolink:AnatomicalEntity	penis	An intromittent organ in certain biologically male organisms. In placental mammals, this also serves as the organ of urination.	EHDAA:9380|OpenCyc:Mx4rvVjkCZwpEbGdrcN5Y29ycA|EHDAA2:0001433|EMAPA:18682|EMAPA_RETIRED:18996|CALOHA:TS-0758|MA:0000408|FMA:9707|MAT:0000186|galen:Penis|NCIT:C12409|MIAA:0000186|UMLS:C0030851|GAID:389|MESH:D010413|EV:0100107|EFO:0000987|VHOG:0000727|BTO:0000405	hp.json	penes|phallus	http://purl.obolibrary.org/obo/UBERON_0000989		organ_slim|pheno_slim|efo_slim|uberon_slim
UBERON:0000985	biolink:AnatomicalEntity	axillary vein	Vein that drains the axilla.	MESH:D001367|galen:AxillaryVein|FMA:13329|OpenCyc:Mx4rwLSHK5wpEbGdrcN5Y29ycA|GAID:527|MA:0002084|NCIT:C32171|EMAPA:18758|UMLS:C0004456	hp.json	subcostal vein|vena axillaris	http://purl.obolibrary.org/obo/UBERON_0000985		human_reference_atlas|uberon_slim
UBERON:0000988	biolink:AnatomicalEntity	pons	The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum.	NCIT:C12511|MAT:0000115|DHBA:10661|BIRNLEX:733|SCTID:279103004|HBA:9131|UMLS:C0032639|BAMS:Pons|BAMS:PONS|CALOHA:TS-0813|MIAA:0000115|Wikipedia:Pons|FMA:67943|EV:0100253|BTO:0001101|MBA:771|BM:Pons|EFO:0001394|GAID:578|EHDAA2:0004394|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=547|UMLS:C1280999|MA:0000204|VHOG:0001176|MESH:D011149|UMLS:C0032639|EMAPA:17563	hp.json	pons Varolii|pons cerebri|pons of Varolius	http://purl.obolibrary.org/obo/UBERON_0000988		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0010312	biolink:AnatomicalEntity	immature eye	Developing anatomical structure that develops into the eyeball and associated structures.	TAO:0002201|ZFA:0001678	hp.json	future eye	http://purl.obolibrary.org/obo/UBERON_0010312		
CHEBI:27780	biolink:ChemicalSubstance	detergent	A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions.	KEGG:C01689	hp.json	Detergents|detergent	http://purl.obolibrary.org/obo/CHEBI_27780		3_STAR
UBERON:0010304	biolink:AnatomicalEntity	non-keratinized stratified squamous epithelium	Stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesizes but does not accumulate keratin. Examples: epithelium of vagina, epithelium of wall of esophagus.	FMA:45569	hp.json	stratified squamous nonkeratinizing epithelium|stratified squamous non-keratinized epithelium|nonkeratinizing stratified squamous epithelium|epithelium stratificatum squamosum noncornificatum	http://purl.obolibrary.org/obo/UBERON_0010304		
HP:0009519	biolink:PhenotypicFeature	Ivory epiphysis of the middle phalanx of the 2nd finger		UMLS:C4024314	hp.json	Increased bone density of end part of the middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0009519		
UBERON:0010305	biolink:AnatomicalEntity	subdivision of conjunctiva	One of the three major regions of the conjunctiva.	FMA:59023	hp.json	region of conjunctiva|conjunctiva region	http://purl.obolibrary.org/obo/UBERON_0010305		grouping_class
HP:0009518	biolink:PhenotypicFeature	Irregular epiphysis of the middle phalanx of the 2nd finger		UMLS:C4024315	hp.json	Irregular end part of the middle long bone of the index finger	http://purl.obolibrary.org/obo/HP_0009518		
UBERON:0010303	biolink:AnatomicalEntity	extraembryonic epithelium	An epithelium that is part of a extraembryonic structure.		hp.json	extra-embryonic epithelium	http://purl.obolibrary.org/obo/UBERON_0010303		
HP:0009515	biolink:PhenotypicFeature	Cone-shaped epiphysis of the middle phalanx of the 2nd finger		UMLS:C4021458	hp.json	Cone-shaped end part of the middle long bone of the index finger|Cone-shaped epiphyses of middle phalanx of index finger	http://purl.obolibrary.org/obo/HP_0009515		
UBERON:0010309	biolink:AnatomicalEntity	palpebral bone	An ossified element investing the upper eyelid.		hp.json	palpebral	http://purl.obolibrary.org/obo/UBERON_0010309		
HP:0009514	biolink:PhenotypicFeature	Bracket epiphysis of the middle phalanx of the 2nd finger	An abnormality of the middle phalanx of the second finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024318	hp.json	Bracket shaped end part of the middle long bone of the index finger	http://purl.obolibrary.org/obo/HP_0009514		
HP:0009517	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the middle phalanx of the 2nd finger		UMLS:C4024316	hp.json	Fragmentation of end part of the middle long bone of the index finger	http://purl.obolibrary.org/obo/HP_0009517		
UBERON:0010306	biolink:AnatomicalEntity	bulbar conjunctiva	The conjunctiva covering the anterior surface of the sclera and the surface epithelium of the cornea.	NCIT:C12902|UMLS:C0229275|FMA:59024	hp.json	ocular conjunctiva	http://purl.obolibrary.org/obo/UBERON_0010306		pheno_slim
HP:0009516	biolink:PhenotypicFeature	Enlarged epiphysis of the middle phalanx of the 2nd finger		UMLS:C4024317	hp.json	Enlarged end part of the middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0009516		
UBERON:0000992	biolink:AnatomicalEntity	ovary	The gonad of a female organism which contains germ cells.	MESH:D010053|MIAA:0000125|BILA:0000125|SCTID:181464007|FMA:7209|EHDAA:8124|EHDAA2:0001360|UMLS:C0029939|ZFA:0000403|AAO:0000371|CALOHA:TS-0730|XAO:0000258|EMAPA:17962|GAID:367|TAO:0000403|FBbt:00004865|NCIT:C12404|BSA:0000080|VHOG:0000251|Wikipedia:Ovary|OpenCyc:Mx4rvVi9QJwpEbGdrcN5Y29ycA|BTO:0000975|EFO:0000973|MA:0000384|EV:0100111	hp.json	gonad of female organism reproductive system|animal ovary|female organism genitalia gonada|female gonad|reproductive system of female organism gonad|gonada of female organism genitalia|female organism reproductive system gonad|gonad of female organism genitalia|gonad of female reproductive system|ovaries|ovum-producing ovary|gonad of genitalia of female organism|gonada of female reproductive system|gonada of genitalia of female organism|ovarium|female organism reproductive system gonada|ovarium|reproductive system of female organism gonada|female organism genitalia gonad|gonad of reproductive system of female organism|gonada of reproductive system of female organism|genitalia of female organism gonada|female reproductive system gonada|female reproductive system gonad|gonada of female organism reproductive system|genitalia of female organism gonad	http://purl.obolibrary.org/obo/UBERON_0000992		efo_slim|human_reference_atlas|uberon_slim|vertebrate_core|organ_slim|pheno_slim
HP:0009511	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the 2nd finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 2nd finger.	UMLS:C4024320	hp.json	Speckled calcifications in end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009511		
UBERON:0000993	biolink:AnatomicalEntity	oviduct	A tube or collection of tubes in an animal from the ovaries to the outside of the body.	TAO:0000560|MIAA:0000126|XAO:0003052|BTO:0000980|VHOG:0001136|NCIT:C77957|Wikipedia:Oviduct|BSA:0000083|EMAPA:18984|GAID:366|MAT:0000126|AAO:0010533|ZFA:0000560|EFO:0000974|MESH:D010057|UMLS:C0029954	hp.json	oviducts|tubular parts of female reproductive system|tubular parts of female reproductive system|female reproductive tracts|uterine tube|female reproductive tracts|tuba uterinae|ovarian tube|ovarian tube|ovarian duct|tuba uterina|ovarian duct	http://purl.obolibrary.org/obo/UBERON_0000993		efo_slim|uberon_slim|vertebrate_core
HP:0009510	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the 2nd finger	Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 2nd finger with respect to age-dependent norms.	UMLS:C4024321	hp.json	Small end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009510		
HP:0009513	biolink:PhenotypicFeature	Absent epiphysis of the middle phalanx of the 2nd finger		UMLS:C4021459	hp.json	Missing end part of the middle long bone of the index finger|Absent epiphyses of middle phalanx of index finger	http://purl.obolibrary.org/obo/HP_0009513		
UBERON:0000995	biolink:AnatomicalEntity	uterus	The female muscular organ of gestation in which the developing embryo or fetus is nourished until birth.	BTO:0001424|MIAA:0000127|OpenCyc:Mx4rvViojJwpEbGdrcN5Y29ycA|GAID:172|EMAPA:29915|VHOG:0001137|UMLS:C0042149|SCTID:181452004|FMA:17558|CALOHA:TS-1102|NCIT:C12405|MA:0000389|Wikipedia:Uterus|MAT:0000127|EFO:0000975|EV:0100113|MESH:D014599|galen:Uterus	hp.json		http://purl.obolibrary.org/obo/UBERON_0000995		pheno_slim|human_reference_atlas|efo_slim|uberon_slim|organ_slim
HP:0009512	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the 2nd finger	A triangular appearance of the epiphysis of the distal phalanx of the 2nd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4024319	hp.json	Triangular end part of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009512		
UBERON:0000990	biolink:AnatomicalEntity	reproductive system	Anatomical system that has as its parts the organs concerned with reproduction.	EFO:0000809|FMA:7160|SCTID:278875001|FBbt:00004857|MA:0000326|HAO:0000895|ZFA:0000632|Wikipedia:Reproductive_system|OpenCyc:Mx4rvVja4ZwpEbGdrcN5Y29ycA|EHDAA2:0001603|UMLS:C1261210|EHDAA:5923|TAO:0000632|BTO:0000081|HAO:0000374|GAID:363|XAO:0000142|NCIT:C12841|AAO:0010258|VHOG:0000182|MIAA:0000305|WBbt:0005747|CALOHA:TS-1318|EV:0100100|BILA:0000103|EMAPA:17381	hp.json	genital tract|systemata genitalia|systemata genitalia|genital system|genitalia|animal reproductive system|organa genitalia|reproductive tract|Geschlechtsorgan|reproductive tissue	http://purl.obolibrary.org/obo/UBERON_0000990		efo_slim|uberon_slim|vertebrate_core|functional_classification|pheno_slim
UBERON:0000991	biolink:AnatomicalEntity	gonad	Reproductive organ that produces and releases eggs (ovary) or sperm (testis).	FMA:18250|Wikipedia:Gonad|BILA:0000123|FBbt:00004858|VHOG:0000397|ZFA:0000413|MESH:D006066|HAO:0000379|NCIT:C12725|GAID:368|UMLS:C0018067|TAO:0000413|WBbt:0005175|SCTID:304623008|XAO:0003146|OpenCyc:Mx4rwQvdiZwpEbGdrcN5Y29ycA|MA:0002420|AAO:0000213|BTO:0000534|EMAPA:17383|BSA:0000079	hp.json	gonads|gonada	http://purl.obolibrary.org/obo/UBERON_0000991		uberon_slim|vertebrate_core|major_organ|organ_slim|pheno_slim
CHEBI:62081	biolink:ChemicalSubstance	1,1-diunsubstituted alkanesulfonate	An alkanesulfonate in which the carbon at position 1 is attached to at least two hydrogens.	MetaCyc:Alkanesulfonates|KEGG:C15521	hp.json	1,1-di-unsubstituted alkanesulfonates|1,1-diunsubstituted alkanesulfonates|1,1-di-unsubstituted alkanesulfonate	http://purl.obolibrary.org/obo/CHEBI_62081		3_STAR
CL:0000006	biolink:Cell	neuronal receptor cell			hp.json	neuronal receptor cell (sensu Animalia)	http://purl.obolibrary.org/obo/CL_0000006		
CL:0000007	biolink:Cell	early embryonic cell (metazoa)	A cell found in the embryo before the formation of all the gem layers is complete.		hp.json		http://purl.obolibrary.org/obo/CL_0000007		
CL:0000008	biolink:Cell	migratory cranial neural crest cell	Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination.		hp.json		http://purl.obolibrary.org/obo/CL_0000008		
CL:0000000	biolink:Cell	cell	A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.	KUPO:0000002|GO:0005623|CALOHA:TS-2035|XAO:0003012|FMA:68646|WBbt:0004017|VHOG:0001533	hp.json		http://purl.obolibrary.org/obo/CL_0000000		_upper_level
CL:0002663	biolink:Cell	myocardial endocrine cell of atrium	A myocardial endocrine cell that is part of the atrium.	FMA:83389	hp.json		http://purl.obolibrary.org/obo/CL_0002663		
CL:0002664	biolink:Cell	cardioblast	A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart.		hp.json	cardiovascular progenitor cell|CPC	http://purl.obolibrary.org/obo/CL_0002664		
CL:0000003	biolink:Cell	native cell	A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment).	CARO:0000013	hp.json	cell in vivo	http://purl.obolibrary.org/obo/CL_0000003		_upper_level
CL:0000005	biolink:Cell	fibroblast neural crest derived	Any fibroblast that is deriived from the neural crest.		hp.json		http://purl.obolibrary.org/obo/CL_0000005		
CL:0000017	biolink:Cell	spermatocyte	A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids.	FBbt:00004936|WBbt:0006799|CALOHA:TS-0951|BTO:0001275|EMAPA:31484|FMA:84049	hp.json		http://purl.obolibrary.org/obo/CL_0000017		
CHEBI:49096	biolink:ChemicalSubstance	3-aminoisobutyrate	A beta-amino acid anion that is the conjugate base of 3-aminoisobutyric acid, arising from deprotonation of the carboxy group.	PMID:17190852	hp.json	beta-aminoisobutyrate|3-amino-2-methylpropanoate	http://purl.obolibrary.org/obo/CHEBI_49096		3_STAR
CL:0000018	biolink:Cell	spermatid	A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa.	WBbt:0006800|EMAPA:31486|CALOHA:TS-0950|FMA:72294|BTO:0001274|FBbt:00004942	hp.json	nematoblast	http://purl.obolibrary.org/obo/CL_0000018		
CL:0000019	biolink:Cell	sperm	A mature male germ cell that develops from a spermatid.	BTO:0001277|WBbt:0006798|BTO:0002046|FBbt:00004954|CALOHA:TS-0949|FMA:67338	hp.json	sperm cell|spermatozoon|spermatozoid	http://purl.obolibrary.org/obo/CL_0000019		
CL:0002672	biolink:Cell	retinal progenitor cell	A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells.		hp.json		http://purl.obolibrary.org/obo/CL_0002672		
CL:0000011	biolink:Cell	migratory trunk neural crest cell	Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination.		hp.json		http://purl.obolibrary.org/obo/CL_0000011		
CL:0002673	biolink:Cell	tongue muscle cell	A skeletal muscle cell that is part of the tongue.		hp.json		http://purl.obolibrary.org/obo/CL_0002673		
CL:0002676	biolink:Cell	neural crest derived neuroblast	A neuroblast derived from a neural crest cell.		hp.json		http://purl.obolibrary.org/obo/CL_0002676		
CL:0000014	biolink:Cell	germ line stem cell			hp.json	germline stem cell	http://purl.obolibrary.org/obo/CL_0000014		
CL:0000015	biolink:Cell	male germ cell	Male germ cell is a germ cell that supports male gamete production.	ncithesaurus:Spermatogenic_Cell|VHOG:0001531|FMA:72290|MA:0002765	hp.json		http://purl.obolibrary.org/obo/CL_0000015		
CHEBI:49095	biolink:ChemicalSubstance	beta-amino-acid anion			hp.json		http://purl.obolibrary.org/obo/CHEBI_49095		1_STAR
UBERON:4000115	biolink:AnatomicalEntity	mineralized bone tissue	Bone tissue mineralized with hydroxyapatite.		hp.json		http://purl.obolibrary.org/obo/UBERON_4000115		
CL:0002658	biolink:Cell	glandular cell of the large intestine	A glandular epithelial cell of the large intestine.	FMA:87194	hp.json		http://purl.obolibrary.org/obo/CL_0002658		
CL:0002657	biolink:Cell	glandular cell of esophagus	A glandular epithelial cell of the esophagus.	FMA:86548	hp.json		http://purl.obolibrary.org/obo/CL_0002657		
CL:0002659	biolink:Cell	glandular cell of stomach	A glandular epithelial cell that is part of the stomach.	FMA:86554|CALOHA:TS-1284	hp.json		http://purl.obolibrary.org/obo/CL_0002659		
CL:0002656	biolink:Cell	glandular cell of endometrium	A glandular epithelial cell of the endometrium.	FMA:86489	hp.json		http://purl.obolibrary.org/obo/CL_0002656		
CHEBI:8386	biolink:ChemicalSubstance	pregnane		Wikipedia:Pregnane|LIPID_MAPS_instance:LMST02030000	hp.json	pregnane	http://purl.obolibrary.org/obo/CHEBI_8386		3_STAR
CL:0002625	biolink:Cell	seminiferous tubule epithelial cell	A cell of the seminiferous tubule epithelium.		hp.json		http://purl.obolibrary.org/obo/CL_0002625		
CHEBI:25094	biolink:ChemicalSubstance	lysine	A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.	KEGG:C16440|CAS:70-54-2|PMID:22264337|CAS:70-54-2|Gmelin:279284|Reaxys:1616991|Beilstein:1616991|Wikipedia:Lysine|PMID:17439666	hp.json	alpha,epsilon-diaminocaproic acid|Lysin|K|lysine|LYS|2,6-diaminohexanoic acid	http://purl.obolibrary.org/obo/CHEBI_25094		3_STAR
CL:0002620	biolink:Cell	skin fibroblast	A fibroblast of skin.	CALOHA:TS-0935|BTO:0001255	hp.json		http://purl.obolibrary.org/obo/CL_0002620		
CHEBI:50047	biolink:ChemicalSubstance	organic amino compound	A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups.		hp.json	organic amino compounds	http://purl.obolibrary.org/obo/CHEBI_50047		3_STAR
GO:1904528	biolink:BiologicalProcess	positive regulation of microtubule binding	Any process that activates or increases the frequency, rate or extent of microtubule binding.		hp.json	up-regulation of microtubule severing activity|upregulation of microtubule/chromatin interaction|activation of microtubule/chromatin interaction|up regulation of microtubule severing activity|up-regulation of microtubule binding|positive regulation of microtubule severing activity|up regulation of microtubule binding|up-regulation of microtubule/chromatin interaction|upregulation of microtubule severing activity|activation of microtubule binding|activation of microtubule severing activity|up regulation of microtubule/chromatin interaction|upregulation of microtubule binding|positive regulation of microtubule/chromatin interaction	http://purl.obolibrary.org/obo/GO_1904528		
GO:1904527	biolink:BiologicalProcess	negative regulation of microtubule binding	Any process that stops, prevents or reduces the frequency, rate or extent of microtubule binding.		hp.json	downregulation of microtubule severing activity|down regulation of microtubule binding|down-regulation of microtubule/chromatin interaction|negative regulation of microtubule/chromatin interaction|inhibition of microtubule binding|down regulation of microtubule/chromatin interaction|downregulation of microtubule binding|inhibition of microtubule severing activity|downregulation of microtubule/chromatin interaction|negative regulation of microtubule severing activity|down-regulation of microtubule severing activity|down regulation of microtubule severing activity|down-regulation of microtubule binding|inhibition of microtubule/chromatin interaction	http://purl.obolibrary.org/obo/GO_1904527		
GO:1904526	biolink:BiologicalProcess	regulation of microtubule binding	Any process that modulates the frequency, rate or extent of microtubule binding.		hp.json	regulation of microtubule/chromatin interaction|regulation of microtubule severing activity	http://purl.obolibrary.org/obo/GO_1904526		
NCBITaxon:2611352	biolink:OrganismalEntity	Discoba		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_2611352		
CL:0002637	biolink:Cell	keratinized epithelial cell of the anal canal	An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal.		hp.json		http://purl.obolibrary.org/obo/CL_0002637		
CL:0002632	biolink:Cell	epithelial cell of lower respiratory tract			hp.json		http://purl.obolibrary.org/obo/CL_0002632		
CL:0002634	biolink:Cell	epithelial cell of anal column	An epithelial cell of the anal column.		hp.json		http://purl.obolibrary.org/obo/CL_0002634		
GO:0015980	biolink:NamedThing	energy derivation by oxidation of organic compounds			hp.json		http://purl.obolibrary.org/obo/GO_0015980		
CL:0002607	biolink:Cell	migratory enteric neural crest cell	A neural crest cell that gives rise to cells of the enteric nervous system.		hp.json		http://purl.obolibrary.org/obo/CL_0002607		
CL:0002601	biolink:Cell	uterine smooth muscle cell	A smooth muscle cell of the uterus.		hp.json		http://purl.obolibrary.org/obo/CL_0002601		
CHEBI:37054	biolink:ChemicalSubstance	3-hydroxybutyrate	A hydroxy fatty acid anion that is the conjugate base of 3-hydroxybutyric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.	Reaxys:4127635|Beilstein:4127635	hp.json	3-hydroxybutanoate|DL-3-hydroxybutyrate|3-OH butyrate|3-OH-butyrate|beta-hydroxy-n-butyrate|beta-hydroxybutanoate|3-hydroxybutanoate	http://purl.obolibrary.org/obo/CHEBI_37054		3_STAR
CL:0002610	biolink:Cell	raphe nuclei neuron	A neuron of the raphe nuclei.		hp.json		http://purl.obolibrary.org/obo/CL_0002610		
CL:0002612	biolink:Cell	neuron of the ventral spinal cord	A neuron of the ventral spinal cord.		hp.json		http://purl.obolibrary.org/obo/CL_0002612		
CL:0000080	biolink:Cell	circulating cell	A cell which moves among different tissues of the body, via blood, lymph, or other medium.		hp.json		http://purl.obolibrary.org/obo/CL_0000080		
CL:0000081	biolink:Cell	blood cell	A cell found predominately in the blood.	FMA:62844	hp.json		http://purl.obolibrary.org/obo/CL_0000081		
CL:0000082	biolink:Cell	epithelial cell of lung	An epithelial cell of the lung.	BTO:0004299	hp.json	lung epithelial cell	http://purl.obolibrary.org/obo/CL_0000082		
CL:0000083	biolink:Cell	epithelial cell of pancreas	An epithelial cell of the pancreas.	BTO:0000028	hp.json	pancreas epithelial cell|pancreatic epithelial cell	http://purl.obolibrary.org/obo/CL_0000083		
CL:0000084	biolink:Cell	T cell	A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.	FMA:62870|VHOG:0001479|BTO:0000782|CALOHA:TS-1001	hp.json	T-lymphocyte|mature T cell|immature T cell|T-cell|T lymphocyte	http://purl.obolibrary.org/obo/CL_0000084		
CL:0000097	biolink:Cell	mast cell	A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.	FMA:66784|BTO:0000830|CALOHA:TS-0603	hp.json	histaminocyte|mastocyte|labrocyte|tissue basophil	http://purl.obolibrary.org/obo/CL_0000097		
CL:0000098	biolink:Cell	sensory epithelial cell	A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells.	BTO:0004301	hp.json	neuroepithelial cell	http://purl.obolibrary.org/obo/CL_0000098		
CL:0000099	biolink:Cell	interneuron	Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.	FMA:67313|WBbt:0005113|FBbt:00005125|BTO:0003811	hp.json		http://purl.obolibrary.org/obo/CL_0000099		
CL:1000042	biolink:Cell	forebrain neuroblast			hp.json		http://purl.obolibrary.org/obo/CL_1000042		
CL:0000092	biolink:Cell	osteoclast	A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.	FMA:66781|BTO:0000968|CALOHA:TS-0721	hp.json	chondroclast	http://purl.obolibrary.org/obo/CL_0000092		
CHEBI:76655	biolink:ChemicalSubstance	EC 2.1.* (C1-transferase) inhibitor	A transferase inhibitor inhibiting the action of transferase of a one-carbon-containing group (EC 2.1.*.*).		hp.json	C1-transferase inhibitor|C1-transferase (EC 2.1.*) inhibitor|C1-transferase (EC 2.1.*) inhibitors|C1-transferase inhibitors|EC 2.1.* (C1-transferase) inhibitors|one-carbon-containing group transferase inhibitors|EC 2.1.* inhibitors|EC 2.1.* inhibitor|one-carbon-containing group transferase inhibitor	http://purl.obolibrary.org/obo/CHEBI_76655		3_STAR
CL:0000094	biolink:Cell	granulocyte	A leukocyte with abundant granules in the cytoplasm.	CALOHA:TS-0422|BTO:0000539|FMA:62854|BTO:0001026	hp.json	granular leucocyte|polymorphonuclear leukocyte|granular leukocyte	http://purl.obolibrary.org/obo/CL_0000094		
CL:0000095	biolink:Cell	neuron associated cell			hp.json		http://purl.obolibrary.org/obo/CL_0000095		
CHEBI:15705	biolink:ChemicalSubstance	L-alpha-amino acid	Any alpha-amino acid having L-configuration at the alpha-carbon.	KEGG:C00151	hp.json	L-Amino acid|L-alpha-amino acids|L-alpha-amino acid|L-alpha-amino acids|L-2-Amino acid	http://purl.obolibrary.org/obo/CHEBI_15705		3_STAR
CL:0000064	biolink:Cell	ciliated cell	A cell that has a filiform extrusion of the cell surface.	XAO:0000031|VHOG:0001532	hp.json		http://purl.obolibrary.org/obo/CL_0000064		
CL:0000066	biolink:Cell	epithelial cell	A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.	BTO:0000414|FMA:66768|WBbt:0003672|CARO:0000077|CALOHA:TS-2026|FBbt:00000124	hp.json	epitheliocyte	http://purl.obolibrary.org/obo/CL_0000066		
CL:0000067	biolink:Cell	ciliated epithelial cell	An epithelial cell that has a cilia.	FMA:70605	hp.json		http://purl.obolibrary.org/obo/CL_0000067		
CL:0000068	biolink:Cell	duct epithelial cell	An epithelial cell that is part of a duct.		hp.json		http://purl.obolibrary.org/obo/CL_0000068		
CL:0000069	biolink:Cell	branched duct epithelial cell			hp.json		http://purl.obolibrary.org/obo/CL_0000069		
CL:0000060	biolink:Cell	odontoblast	Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell.	CALOHA:TS-0696|FMA:62999|BTO:0001769	hp.json		http://purl.obolibrary.org/obo/CL_0000060		
HP:0010492	biolink:PhenotypicFeature	Osseous finger syndactyly	Webbing or fusion of the fingers, involving soft parts and including fusion of individual finger bones. Bony fusions are referred to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers in a proximo-distal axis are referred to as "Symphalangism".	SNOMEDCT_US:2560006|UMLS:C0158736	hp.json	Osseous syndactyly of the fingers	http://purl.obolibrary.org/obo/HP_0010492		hposlim_core
HP:0010491	biolink:PhenotypicFeature	Digital constriction ring	A narrow segment of significantly reduced circumference of a digit.	UMLS:C4021261	hp.json	Amniotic constriction rings of digits	http://purl.obolibrary.org/obo/HP_0010491		hposlim_core
HP:0010490	biolink:PhenotypicFeature	Abnormality of the palmar creases	An abnormality of the creases of the skin of palm of hand.	SNOMEDCT_US:205557000|UMLS:C0221199	hp.json	Abnormality of the palm lines	http://purl.obolibrary.org/obo/HP_0010490		hposlim_core
CHEBI:62031	biolink:ChemicalSubstance	polar amino acid zwitterion	Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group.	MetaCyc:Polar-amino-acids	hp.json	a polar amino acid	http://purl.obolibrary.org/obo/CHEBI_62031		2_STAR
HP:0010499	biolink:PhenotypicFeature	Patellar subluxation	The kneecap normally is located within the groove termed trochlea on the distal femur and can slide up and down in it. Patellar subluxation refers to an unstable kneecap that does not slide centrally within its groove, i.e., a partial dislocation of the patella.	UMLS:C0857276	hp.json	Partial knee cap dislocation|Subluxation of patella	http://purl.obolibrary.org/obo/HP_0010499		
HP:0010498	biolink:PhenotypicFeature	Bipartite patella	A developmental defect that occurs if the two halves of the patella fail to fuse in early childhood.	UMLS:C0265666|SNOMEDCT_US:79214007	hp.json		http://purl.obolibrary.org/obo/HP_0010498		hposlim_core
HP:0010497	biolink:PhenotypicFeature	Sirenomelia	A developmental defect in which the legs are fused together.	UMLS:C0037205|MEDDRA:10049216|SNOMEDCT_US:67254002|SNOMEDCT_US:91089008|MSH:D004480|SNOMEDCT_US:253191000	hp.json	Sympodia	http://purl.obolibrary.org/obo/HP_0010497		hposlim_core
HP:0010496	biolink:PhenotypicFeature	Hypertrophy of the lower limb	Abnormal increase in size of the lower limbs (due to an increase of the size of cells).	UMLS:C4023803	hp.json		http://purl.obolibrary.org/obo/HP_0010496		
HP:0010495	biolink:PhenotypicFeature	Amniotic constriction rings of legs	Amniotic constriction rings affecting the legs.	UMLS:C4023804	hp.json		http://purl.obolibrary.org/obo/HP_0010495		
HP:0010494	biolink:PhenotypicFeature	Acromelia of the lower limbs	Shortening of the legs predominantly affecting terminal parts of the leg in relation to the upper and middle arm segments.	UMLS:C4023805	hp.json		http://purl.obolibrary.org/obo/HP_0010494		
HP:0010493	biolink:PhenotypicFeature	Long metacarpals	An abnormally increased length of the metacarpal bones.	UMLS:C4021260	hp.json	Elongated long bone of hand|Increased length of metacarpals	http://purl.obolibrary.org/obo/HP_0010493		hposlim_core
CL:0000075	biolink:Cell	columnar/cuboidal epithelial cell	A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.		hp.json		http://purl.obolibrary.org/obo/CL_0000075		
CL:0000076	biolink:Cell	squamous epithelial cell		CALOHA:TS-1249	hp.json		http://purl.obolibrary.org/obo/CL_0000076		
CL:0000077	biolink:Cell	mesothelial cell	A flattened epithelial cell of mesenchymal origin that lines the serous cavity.	FMA:66773	hp.json	mesotheliocyte	http://purl.obolibrary.org/obo/CL_0000077		
CL:0000079	biolink:Cell	stratified epithelial cell			hp.json		http://purl.obolibrary.org/obo/CL_0000079		
CL:0000071	biolink:Cell	blood vessel endothelial cell	An endothelial cell that lines the vasculature.		hp.json	cuboidal endothelial cell of vascular tree	http://purl.obolibrary.org/obo/CL_0000071		
CL:0000047	biolink:Cell	neuronal stem cell	Neural stem cell is characterized as an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors.	CALOHA:TS-2360|FMA:86684|BTO:0002881	hp.json	NSC|neural stem cell	http://purl.obolibrary.org/obo/CL_0000047		
CL:0000048	biolink:Cell	multi fate stem cell	A stem cell that can give rise to multiple lineages of cells.	FMA:84789	hp.json	multifate stem cell|multi-fate stem cell|multipotent stem cell|multipotent cell	http://purl.obolibrary.org/obo/CL_0000048		
CL:0000049	biolink:Cell	common myeloid progenitor	A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.	BTO:0004730	hp.json	myeloid stem cell|colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte|common myeloid precursor|CMP|CFU-GEMM|pluripotent stem cell (bone marrow)|CFU-S|multipotential myeloid stem cell	http://purl.obolibrary.org/obo/CL_0000049		
CL:0000040	biolink:Cell	monoblast	A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus.	CALOHA:TS-1195|FMA:83553	hp.json	CFU-M|colony forming unit macrophage|colony forming unit monocyte|monocyte stem cell	http://purl.obolibrary.org/obo/CL_0000040		
CL:0000055	biolink:Cell	non-terminally differentiated cell	A precursor cell with a limited number of potential fates.	BTO:0000125|FMA:84782	hp.json	blast cell	http://purl.obolibrary.org/obo/CL_0000055		
CL:0000056	biolink:Cell	myoblast	A cell that is commited to differentiating into a muscle cell.  Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes.  Myoblasts also occur as transient populations of cells in muscles undergoing repair.	FMA:70335|VHOG:0001529|BTO:0000222|FBbt:00005083|CALOHA:TS-0650	hp.json		http://purl.obolibrary.org/obo/CL_0000056		
CL:0000057	biolink:Cell	fibroblast	A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.	VHOG:0001482|CALOHA:TS-0362|FMA:63877|BTO:0000452	hp.json		http://purl.obolibrary.org/obo/CL_0000057		
CL:0000058	biolink:Cell	chondroblast	Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell.	BTO:0003607|FMA:66783	hp.json	chrondoplast	http://purl.obolibrary.org/obo/CL_0000058		
CL:0000059	biolink:Cell	ameloblast	Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell.	FMA:70576|BTO:0001663	hp.json	enamel secreting cell|amelocyte	http://purl.obolibrary.org/obo/CL_0000059		
CL:0000050	biolink:Cell	megakaryocyte-erythroid progenitor cell	A progenitor cell committed to the megakaryocyte and erythroid lineages.		hp.json	colony forming unit erythroid megakaryocyte|MEP|megakaryocyte/erythrocyte progenitor|CFU-EM|megakaryocyte/erythroid progenitor cell|CFU-MegE|Meg/E progenitor	http://purl.obolibrary.org/obo/CL_0000050		
CL:0000051	biolink:Cell	common lymphoid progenitor	A oligopotent progenitor cell committed to the lymphoid lineage.		hp.json	common lymphocyte precursor|lymphoid stem cell|CLP|ELP|early lymphocyte progenitor|lymphopoietic stem cell|common lymphoid precursor|common lymphocyte progenitor|committed lymphopoietic stem cell	http://purl.obolibrary.org/obo/CL_0000051		
CL:0000052	biolink:Cell	totipotent stem cell	A stem cell from which all cells of the body can form.	FMA:84790	hp.json	totipotential stem cell	http://purl.obolibrary.org/obo/CL_0000052		
CL:0000029	biolink:Cell	neural crest derived neuron			hp.json	neuron neural crest derived	http://purl.obolibrary.org/obo/CL_0000029		
CL:0000020	biolink:Cell	spermatogonium	An euploid male germ cell of an early stage of spermatogenesis.	BTO:0000958|FMA:72291|CALOHA:TS-2193|FBbt:00004935|EMAPA:31482	hp.json	spermatogonial cell	http://purl.obolibrary.org/obo/CL_0000020		
CL:0000021	biolink:Cell	female germ cell	Female germ cell is a germ cell that supports female gamete production.	MA:0000388|VHOG:0001530|ncithesaurus:Egg	hp.json		http://purl.obolibrary.org/obo/CL_0000021		
CL:0000022	biolink:Cell	female germ line stem cell			hp.json		http://purl.obolibrary.org/obo/CL_0000022		
CL:0000023	biolink:Cell	oocyte	A female germ cell that has entered meiosis.	FMA:18644|FBbt:00004886|BTO:0000964|CALOHA:TS-0711|WBbt:0006797	hp.json	oogonium	http://purl.obolibrary.org/obo/CL_0000023		
CL:0000024	biolink:Cell	oogonial cell	An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes.	FMA:83673	hp.json		http://purl.obolibrary.org/obo/CL_0000024		
CL:0000025	biolink:Cell	egg cell	A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization.	FMA:67343|MA:0000388|FBbt:00057012|BTO:0000369|BTO:0003801|CALOHA:TS-2191	hp.json	ovum|mature oocyte	http://purl.obolibrary.org/obo/CL_0000025		
CL:0000027	biolink:Cell	smooth muscle cell neural crest derived	A smooth muscle cell derived from the neural crest.		hp.json		http://purl.obolibrary.org/obo/CL_0000027		
CL:0002680	biolink:Cell	PP cell of intestine	A PP cell found in intestine.		hp.json		http://purl.obolibrary.org/obo/CL_0002680		
CL:0000039	biolink:Cell	germ line cell	A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.		hp.json		http://purl.obolibrary.org/obo/CL_0000039		_upper_level
CL:0012001	biolink:Cell	neuron of the forebrain	A CNS neuron of the forebrain.		hp.json	forebrain neuron	http://purl.obolibrary.org/obo/CL_0012001		
CL:0000031	biolink:Cell	neuroblast (sensu Vertebrata)	A cell that will develop into a neuron often after a migration phase.	FMA:70563|BTO:0000930	hp.json	neuroblast	http://purl.obolibrary.org/obo/CL_0000031		
CL:0000034	biolink:Cell	stem cell	A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.	CALOHA:TS-2086|FMA:63368	hp.json	animal stem cell	http://purl.obolibrary.org/obo/CL_0000034		
PR:000000001	biolink:Protein	protein	An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.		hp.json	natural protein|native protein	http://purl.obolibrary.org/obo/PR_000000001		
CL:0000035	biolink:Cell	single fate stem cell	A stem cell that self-renews as well as give rise to a single mature cell type.	FMA:70569	hp.json	unipotent stem cell|unipotential stem cell	http://purl.obolibrary.org/obo/CL_0000035		
CL:0000036	biolink:Cell	epithelial fate stem cell			hp.json	epithelial stem cell	http://purl.obolibrary.org/obo/CL_0000036		
CL:0000037	biolink:Cell	hematopoietic stem cell	A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.	VHOG:0001485|FMA:70337|BTO:0000725|CALOHA:TS-0448|FMA:86475	hp.json	blood forming stem cell|colony forming unit hematopoietic|hemopoietic stem cell|HSC	http://purl.obolibrary.org/obo/CL_0000037		
CL:0000038	biolink:Cell	erythroid progenitor cell	A progenitor cell committed to the erythroid lineage.	BTO:0004911	hp.json	blast forming unit erythroid|colony forming unit erythroid|erythroid stem cell|burst forming unit erythroid|CFU-E|BFU-E	http://purl.obolibrary.org/obo/CL_0000038		
CL:0000030	biolink:Cell	glioblast		FBbt:00005145	hp.json		http://purl.obolibrary.org/obo/CL_0000030		
HP:0012860	biolink:PhenotypicFeature	Testicular fibrosis	Formation of excess connective tissue in the testicle.	UMLS:C4021061	hp.json	Fibrotic testicle|Fibrotic testes	http://purl.obolibrary.org/obo/HP_0012860		
CHEBI:27638	biolink:ChemicalSubstance	cobalt atom	A cobalt group element atom that has atomic number 27.	KEGG:C19171|CAS:7440-48-4|KEGG:C00175|WebElements:Co|CAS:7440-48-4|PDBeChem:3CO|CAS:7440-48-4	hp.json	cobaltum|Cobalt|cobalt|cobalt|Kobalt|27Co|Co|Co|cobalto	http://purl.obolibrary.org/obo/CHEBI_27638		3_STAR
HP:0012861	biolink:PhenotypicFeature	Ovotestis	A gonad that contains both ovarian follicles and testicular tubular elements.	MSH:D050090|SNOMEDCT_US:18978002|UMLS:C0266361	hp.json		http://purl.obolibrary.org/obo/HP_0012861		
GO:1990874	biolink:BiologicalProcess	vascular associated smooth muscle cell proliferation	The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.		hp.json	vascular smooth muscle cell proliferation|VSMC proliferation	http://purl.obolibrary.org/obo/GO_1990874		
HP:0012862	biolink:PhenotypicFeature	Abnormal germ cell morphology	Any structural anomaly of a reproductive cell.	UMLS:C4022704	hp.json	Abnormally shaped reproductive cell|Abnormally shaped germ cell|Abnormal shape of a reproductive cell	http://purl.obolibrary.org/obo/HP_0012862		
HP:0012863	biolink:PhenotypicFeature	Abnormal male germ cell morphology	A structural anomaly of a male reproductive cell.	UMLS:C4022703	hp.json		http://purl.obolibrary.org/obo/HP_0012863		
HP:0012864	biolink:PhenotypicFeature	Abnormal sperm morphology	A structural anomaly of sperm.	SNOMEDCT_US:236817003|UMLS:C0403824|MSH:D000072660	hp.json	Teratospermia|Teratozoospermia|Abnormal shape of sperm	http://purl.obolibrary.org/obo/HP_0012864		
UBERON:0009030	biolink:AnatomicalEntity	left pulmonary vein	Vein that drains left lung and returns blood to the heart.	UMLS:C0226670|EMAPA:37165|MA:0002207|SCTID:304057004|NCIT:C48946	hp.json		http://purl.obolibrary.org/obo/UBERON_0009030		
HP:0012865	biolink:PhenotypicFeature	Abnormal sperm head morphology	A structural abnormality of the sperm head.	UMLS:C4022702	hp.json	Sperm head anomaly	http://purl.obolibrary.org/obo/HP_0012865		
HP:0010203	biolink:PhenotypicFeature	Aplasia/hypoplasia of proximal toe phalanx	Absence (agenesis) or underdevelopment of the proximal phalanx of the toe.	UMLS:C4021317	hp.json	Absent/underdeveloped innermost toe bones|Aplasia/Hypoplasia of the proximal phalanges of the toes|Absent/small innermost toe bones	http://purl.obolibrary.org/obo/HP_0010203		
HP:0000877	biolink:PhenotypicFeature	Insulin-resistant diabetes mellitus at puberty		UMLS:C1837792	hp.json	Insulin-resistant diabetes mellitus at puberty	http://purl.obolibrary.org/obo/HP_0000877		
HP:0000876	biolink:PhenotypicFeature	Oligomenorrhea	Infrequent menses (less than 6 per year or more than 35 days between cycles).	MSH:D009839|UMLS:C0028949|SNOMEDCT_US:52073004	hp.json	Light or infrequent menstrual periods	http://purl.obolibrary.org/obo/HP_0000876		
HP:0010202	biolink:PhenotypicFeature	Duplication of middle phalanx of toe	Partial or complete duplication of a middle phalanx of toe.	UMLS:C4021318	hp.json	Partial/complete duplication of the middle bones of the toes|Partial/complete duplication of the middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010202		
HP:0000879	biolink:PhenotypicFeature	Short sternum	Decreased inferosuperior length of the sternum.	SNOMEDCT_US:298724002|UMLS:C4020883|UMLS:C0575497	hp.json	Hypoplastic sternum|Short sternum	http://purl.obolibrary.org/obo/HP_0000879		hposlim_core
HP:0010201	biolink:PhenotypicFeature	Triangular shaped middle phalanges of the toes		UMLS:C4023972	hp.json	Triangular shaped middle bones of toes	http://purl.obolibrary.org/obo/HP_0010201		
UBERON:0010020	biolink:AnatomicalEntity	tubotympanic recess epithelium	The dorsal portion of the embryonic first endodermal pharyngeal pouch; it develops into the middle ear cavity.	EHDAA2:0004115|EHDAA:6772|MA:0001218|NCIT:C34318|VHOG:0001297|EMAPA:17002|UMLS:C1284046|FMA:312393	hp.json	tubotympanic recess	http://purl.obolibrary.org/obo/UBERON_0010020		
HP:0000878	biolink:PhenotypicFeature	11 pairs of ribs	Presence of only 11 pairs of ribs.	UMLS:C1839731	hp.json	11 pairs of ribs	http://purl.obolibrary.org/obo/HP_0000878		hposlim_core
HP:0010200	biolink:PhenotypicFeature	Symphalangism affecting the middle phalanges of the toes		UMLS:C4023973	hp.json	Fused middle bones of toes	http://purl.obolibrary.org/obo/HP_0010200		
UBERON:0010025	biolink:AnatomicalEntity	dorsal part of pharyngeal pouch 3		EMAPA:16758|EHDAA2:0000409	hp.json	cranial dorsal aspect of third dorsal pharyngeal pouch|dorsal 3rd branchial pouch|dorsal wing of pharyngeal pouch 3|dorsal 3rd arch pharyngeal pouch endoderm|dorsal branchial pouch 3 endoderm|dorsal pharyngeal pouch 3|dorsal pharyngeal pouch 3 endoderm	http://purl.obolibrary.org/obo/UBERON_0010025		
UBERON:0036655	biolink:AnatomicalEntity	wall of cerebral aqueduct		FMA:242774	hp.json		http://purl.obolibrary.org/obo/UBERON_0036655		
UBERON:0010026	biolink:AnatomicalEntity	ventral part of pharyngeal pouch 3		EMAPA:16759|EHDAA2:0002173	hp.json	caudal ventral aspect of third dorsal pharyngeal pouch|ventral pharyngeal pouch 3|ventral 3rd branchial pouch|ventral 3rd arch pharyngeal pouch endoderm|ventral wing of pharyngeal pouch 3|ventral branchial pouch 3 endoderm|ventral pharyngeal pouch 3 endoderm	http://purl.obolibrary.org/obo/UBERON_0010026		
UBERON:0036654	biolink:AnatomicalEntity	wall of lateral ventricle		FMA:242772	hp.json		http://purl.obolibrary.org/obo/UBERON_0036654		
UBERON:0036657	biolink:AnatomicalEntity	wall of fourth ventricle		FMA:242778	hp.json		http://purl.obolibrary.org/obo/UBERON_0036657		
UBERON:0036656	biolink:AnatomicalEntity	wall of third ventricle		FMA:242776	hp.json		http://purl.obolibrary.org/obo/UBERON_0036656		
HP:0000871	biolink:PhenotypicFeature	Panhypopituitarism	A pituitary functional deficit affecting all the anterior pituitary hormones (growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone, and prolactin).	MSH:C580003|SNOMEDCT_US:32390006|UMLS:C0242343	hp.json		http://purl.obolibrary.org/obo/HP_0000871		
HP:0010209	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanges of the toes		UMLS:C4023970	hp.json	Fused innermost bones of toes	http://purl.obolibrary.org/obo/HP_0010209		
HP:0000870	biolink:PhenotypicFeature	Increased circulating prolactin concentration	The presence of abnormally increased levels of prolactin in the blood. Prolactin is a peptide hormone produced by the anterior pituitary gland that plays a role in breast development and lactation during pregnancy.	UMLS:C0020514|MSH:D006966|SNOMEDCT_US:237662005	hp.json	Prolactin excess|Hyperprolactinemia|Hyperprolactinaemia	http://purl.obolibrary.org/obo/HP_0000870		
HP:0010208	biolink:PhenotypicFeature	Patchy sclerosis of proximal toe phalanx	Patchy (irregular) increase in bone density of one or more of the proximal phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4021313	hp.json	Patchy sclerosis of the proximal phalanges of the toes|Uneven increase in bone density in innermost toe bone	http://purl.obolibrary.org/obo/HP_0010208		
HP:0000873	biolink:PhenotypicFeature	Diabetes insipidus	A state of excessive water intake and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus).	UMLS:C0011848|SNOMEDCT_US:15771004|MSH:D003919	hp.json		http://purl.obolibrary.org/obo/HP_0000873		
HP:0010207	biolink:PhenotypicFeature	Osteolytic defect of the proximal toe phalanx	Dissolution or degeneration of bone tissue of the proximal toe phalanx.	UMLS:C4021314	hp.json	Osteolytic defects of the proximal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010207		
HP:0009207	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the middle phalanx of the 5th finger	Fragmented appearance of the epiphysis of the middle phalanx of the 5th finger.	UMLS:C4024533	hp.json	Fragmentation of end part of the middle bone of the pinky finger|Fragmentation of end part of the middle bone of the pinkie finger|Fragmentation of end part of the middle bone of the little finger	http://purl.obolibrary.org/obo/HP_0009207		
HP:0000872	biolink:PhenotypicFeature	Hashimoto thyroiditis	A chronic, autoimmune type of thyroiditis associated with hypothyroidism.	SNOMEDCT_US:21983002|MSH:D050031|UMLS:C0677607	hp.json	Chronic lymphocytic thyroiditis|Hashimoto's thyroiditis	http://purl.obolibrary.org/obo/HP_0000872		
HP:0010206	biolink:PhenotypicFeature	Curved proximal toe phalanx	A deviation from the normal straight shape of a proximal phalanx of one or more toes.	UMLS:C4021315	hp.json	Curved innermost toe bones|Curved proximal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010206		
HP:0009206	biolink:PhenotypicFeature	Enlarged epiphysis of the middle phalanx of the 5th finger	Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 5th finger with respect to age-dependent norms.	UMLS:C4024534	hp.json	Enlarged end part of the middle bone of the pinky finger|Enlarged end part of the middle bone of the pinkie finger|Enlarged end part of the middle bone of the little finger	http://purl.obolibrary.org/obo/HP_0009206		
HP:0010205	biolink:PhenotypicFeature	Bullet-shaped proximal toe phalanx	An abnormal morphology of one or more of the proximal phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021316	hp.json	Bullet-shaped proximal phalanges of the toes|Bullet-shaped proximal phalanges of toe|Bullet-shaped innermost toe bone	http://purl.obolibrary.org/obo/HP_0010205		
HP:0000875	biolink:PhenotypicFeature	Episodic hypertension		UMLS:C1857175	hp.json	Intermittent high blood pressure	http://purl.obolibrary.org/obo/HP_0000875		
HP:0009209	biolink:PhenotypicFeature	Ivory epiphysis of the middle phalanx of the 5th finger	Sclerosis of the epiphysis of the middle phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024531	hp.json	Increased bone density of end part of the middle bone of pinkie finger|Increased bone density of end part of the middle bone of little finger|Increased bone density of end part of the middle bone of pinky finger	http://purl.obolibrary.org/obo/HP_0009209		
HP:0009208	biolink:PhenotypicFeature	Irregular epiphysis of the middle phalanx of the 5th finger	Irregular radiographic opacity of the epiphysis of the middle phalanx of the 5th finger.	UMLS:C4024532	hp.json	Irregular end part of the middle bone of the pinky finger|Irregular end part of the middle bone of the pinkie finger|Irregular end part of the middle bone of the little finger	http://purl.obolibrary.org/obo/HP_0009208		
HP:0010204	biolink:PhenotypicFeature	Broad proximal phalanx of toe	An increase in width of one ore more proximal toe phalanges.	UMLS:C4023971	hp.json	Broad innermost toe bone	http://purl.obolibrary.org/obo/HP_0010204		
HP:0009203	biolink:PhenotypicFeature	Absent epiphysis of the middle phalanx of the 5th finger	Absence of the epiphysis located at the proximal end of the middle phalanx of the 5th finger.	UMLS:C4024537	hp.json	Absent end part of the middle bone of the little finger|Absent end part of the middle bone of the pinkie finger|Absent end part of the middle bone of the pinky finger	http://purl.obolibrary.org/obo/HP_0009203		
HP:0012866	biolink:PhenotypicFeature	Abnormal sperm neck morphology	A structural abnormality of the sperm neck.	UMLS:C4022701	hp.json	Sperm neck anomaly	http://purl.obolibrary.org/obo/HP_0012866		
UBERON:0009032	biolink:AnatomicalEntity	right pulmonary vein	Vein that drains right lung and returns blood to the heart.	EMAPA:37379|UMLS:C0226669|SCTID:304056008|MA:0002208|NCIT:C48947	hp.json		http://purl.obolibrary.org/obo/UBERON_0009032		
HP:0009202	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the 5th finger	Fragmented appearance of the epiphysis of the proximal phalanx of the 5th finger.	UMLS:C4024538	hp.json	Fragmentation of end part of the innermost bone of the little finger|Fragmentation of end part of the innermost bone of the pinky finger|Fragmentation of end part of the innermost bone of the pinkie finger	http://purl.obolibrary.org/obo/HP_0009202		
HP:0012867	biolink:PhenotypicFeature	Abnormal sperm mid-piece morphology	A structural abnormality of the sperm mid-piece.	UMLS:C4022700	hp.json	Sperm mid-piece anomaly	http://purl.obolibrary.org/obo/HP_0012867		
HP:0009205	biolink:PhenotypicFeature	Cone-shaped epiphysis of the middle phalanx of the 5th finger	A cone-shaped appearance of the epiphysis of the middle phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4024535	hp.json	Cone-shaped end part of the middle bone of the pinkie finger|Cone-shaped end part of the middle bone of the little finger|Cone-shaped end part of the middle bone of the pinky finger	http://purl.obolibrary.org/obo/HP_0009205		
HP:0012868	biolink:PhenotypicFeature	Abnormal sperm tail morphology	A structural abnormality of the sperm tail.	UMLS:C4022699	hp.json	Sperm tail anomaly	http://purl.obolibrary.org/obo/HP_0012868		
HP:0009204	biolink:PhenotypicFeature	Bracket epiphysis of the middle phalanx of the 5th finger	An abnormality of the middle phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024536	hp.json	Bracket shaped end part of the middle bone of the little finger|Bracket shaped end part of the middle bone of the pinky finger|Bracket shaped end part of the middle bone of the pinkie finger	http://purl.obolibrary.org/obo/HP_0009204		
HP:0012869	biolink:PhenotypicFeature	Acephalic spermatozoa	Spermatozoa with very small cranial ends devoid of any nuclear material, that is, lacking a typical sperm head.	UMLS:C4022698	hp.json		http://purl.obolibrary.org/obo/HP_0012869		
HP:0009201	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the 5th finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 5th finger.	UMLS:C4024539	hp.json	Speckled calcifications in end part of the innnermost bone of the pinky finger|Speckled calcifications in end part of the innnermost bone of the pinkie finger|Speckled calcifications in end part of the innnermost bone of the little finger	http://purl.obolibrary.org/obo/HP_0009201		
UBERON:0009039	biolink:AnatomicalEntity	lymph node germinal center	A germinal center that is located in a lymph node.	BTO:0003671|NCIT:C49757|EMAPA:35528|CALOHA:TS-1269|MA:0002989	hp.json	germinal center|lymph node light zone|lymph node nodule|lymph node activated zone|lymph node central zone	http://purl.obolibrary.org/obo/UBERON_0009039		pheno_slim|human_reference_atlas
HP:0009200	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the 5th finger	A secondary ossification center in the proximal phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024540	hp.json		http://purl.obolibrary.org/obo/HP_0009200		
HP:0012850	biolink:PhenotypicFeature	Small intestinal dysmotility	Abnormal small intestinal contractions, such as spasms and intestinal paralysis related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes.	SNOMEDCT_US:253768006|UMLS:C0345200	hp.json		http://purl.obolibrary.org/obo/HP_0012850		
HP:0012851	biolink:PhenotypicFeature	Colonic stenosis	A narrowing of a segment of colon whereby bowel continuity is maintained.	SNOMEDCT_US:19132000|UMLS:C0267466|SNOMEDCT_US:8543007	hp.json	Stenosis of the colon|Narrowing of the colon	http://purl.obolibrary.org/obo/HP_0012851		
HP:0012852	biolink:PhenotypicFeature	Hepatic bridging fibrosis	Hepatic fibrosis that reaches from a portal area to another portal area.	UMLS:C4022709	hp.json		http://purl.obolibrary.org/obo/HP_0012852		
HP:0012853	biolink:PhenotypicFeature	Scrotal hypospadias	Hypospadias with location of the urethral meatus in the scrotum.	SNOMEDCT_US:702462000|UMLS:C2197691	hp.json		http://purl.obolibrary.org/obo/HP_0012853		
HP:0012854	biolink:PhenotypicFeature	Midshaft hypospadias	Hypospadias with location of the urethral meatus in the middle of the inferior shaft of the penis.	UMLS:C4022708	hp.json		http://purl.obolibrary.org/obo/HP_0012854		
HP:0000888	biolink:PhenotypicFeature	Horizontal ribs	A horizontal (flat) conformation of the ribs, the long curved bones that form the rib cage and normally progressively oblique (slanted) from ribs 1 through 9, then less slanted through rib 12.	UMLS:C3806510	hp.json	Horizontal ribs	http://purl.obolibrary.org/obo/HP_0000888		
UBERON:0010011	biolink:AnatomicalEntity	collection of basal ganglia	Subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum.	DHBA:10331|BAMS:BG|MBA:623|PBA:4001|UMLS:C0004781|MA:0000184|GAID:617|FMA:84013|BM:Tel-BG|EMAPA:32673|VHOG:0001696|HBA:4276|HBA:4275|BIRNLEX:826|NCIT:C12447|PBA:128012596|MESH:D001479	hp.json	basal ganglia|set of basal nuclei|set of basal ganglia|basal nuclei (basal ganglia)|cerebral nuclei|basal nuclei|basal ganglia set|subcortical nuclei	http://purl.obolibrary.org/obo/UBERON_0010011		pheno_slim|human_reference_atlas
HP:0000887	biolink:PhenotypicFeature	Cupped ribs	Wide, concave rib end.	SNOMEDCT_US:249704008|UMLS:C0426826|UMLS:C1865039	hp.json	Rib cupping|Cupped ribs|Rib flaring	http://purl.obolibrary.org/obo/HP_0000887		hposlim_core
UBERON:0036661	biolink:AnatomicalEntity	wall of ventricular system of brain		FMA:242841	hp.json		http://purl.obolibrary.org/obo/UBERON_0036661		
HP:0000889	biolink:PhenotypicFeature	Abnormal clavicle morphology	Any abnormality of the clavicles (collar bones).	UMLS:C4021792	hp.json	Abnormal collarbone|Abnormality of the clavicle|Abnormal clavicles	http://purl.obolibrary.org/obo/HP_0000889		hposlim_core
UBERON:0009029	biolink:AnatomicalEntity	pudendal vein	Either the internal or external pudendal vein, running from the genital-vulvar area and abdomen and down the leg.	EMAPA:37184|MA:0002202	hp.json	vena pudendae|vena pudendae|vena pudendales|pudic vein	http://purl.obolibrary.org/obo/UBERON_0009029		
UBERON:0036658	biolink:AnatomicalEntity	wall of central canal of spinal cord		FMA:242780	hp.json	wall of central canal	http://purl.obolibrary.org/obo/UBERON_0036658		
HP:0000882	biolink:PhenotypicFeature	Hypoplastic scapulae	Underdeveloped scapula.	UMLS:C1846434	hp.json	Small scapulae|Small scapula|Scapular hypoplasia|Short scapulae|Small shoulder blade|Hypoplastic scapula	http://purl.obolibrary.org/obo/HP_0000882		hposlim_core
UBERON:0010005	biolink:AnatomicalEntity	placental labyrinth villous	The vascularized and branched structures arising from the rodent trophoblast-derived epithelium that allow an increase its surface area for the efficient exchange of nutrients and wastes between the maternal and fetal circulation.		hp.json	placental labyrinth villi|villous of placental labyrinth	http://purl.obolibrary.org/obo/UBERON_0010005		pheno_slim
HP:0000884	biolink:PhenotypicFeature	Prominent sternum		UMLS:C1846433	hp.json	Sternal protrusion|Prominent sternum	http://purl.obolibrary.org/obo/HP_0000884		
HP:0009218	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the middle phalanx of the 4th finger	Fragmented appearance of the epiphysis of the middle phalanx of the 4th finger.	UMLS:C4024523	hp.json	Fragmentation of end part of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009218		
HP:0000883	biolink:PhenotypicFeature	Thin ribs	Ribs with a reduced diameter.	SNOMEDCT_US:249697003|UMLS:C0426818	hp.json	Slender ribs|Thin ribs	http://purl.obolibrary.org/obo/HP_0000883		hposlim_core
HP:0009217	biolink:PhenotypicFeature	Enlarged epiphysis of the middle phalanx of the 4th finger	Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 4th finger with respect to age-dependent norms.	UMLS:C4024524	hp.json	Enlarged end part of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009217		
UBERON:0010009	biolink:AnatomicalEntity	aggregate regional part of brain	A regional part of brain consisting of multiple brain regions that are not related through a simple volummetric part of hierarchy, e.g., basal ganglia[NIF].	FMA:256381|NLXANAT:20090509	hp.json	set of nuclei of neuraxis	http://purl.obolibrary.org/obo/UBERON_0010009		non_informative
HP:0000886	biolink:PhenotypicFeature	Deformed rib cage	Malformation of the rib cage.	UMLS:C1838659	hp.json	Deformed rib cage	http://purl.obolibrary.org/obo/HP_0000886		
HP:0000885	biolink:PhenotypicFeature	Broad ribs	Increased width of ribs	UMLS:C1848654	hp.json	Broad ribs|Wide ribs	http://purl.obolibrary.org/obo/HP_0000885		hposlim_core
HP:0009219	biolink:PhenotypicFeature	Irregular epiphysis of the middle phalanx of the 4th finger	Irregular radiographic opacity of the epiphysis of the middle phalanx of the 4th finger.	UMLS:C4024522	hp.json	Irregular end part of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009219		
HP:0012855	biolink:PhenotypicFeature	Scrotal hyperpigmentation	Increased pigmentation (skin color) of the scrotum.	UMLS:C4021062	hp.json	Increased pigmentation in scrotum|Hyperpigmentation of the scrotum|Hyperpigmented scrotum	http://purl.obolibrary.org/obo/HP_0012855		
HP:0009214	biolink:PhenotypicFeature	Absent epiphysis of the middle phalanx of the 4th finger	Absence of the epiphysis located at the proximal end of the middle phalanx of the 4th finger.	UMLS:C4024527	hp.json	Absent end part of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009214		
HP:0012856	biolink:PhenotypicFeature	Abnormal scrotal rugation	Anomaly of the folded ridges (wrinkles) of skin of the scrotum.	UMLS:C4022707	hp.json		http://purl.obolibrary.org/obo/HP_0012856		
HP:0009213	biolink:PhenotypicFeature	Triangular epiphysis of the middle phalanx of the 5th finger	A triangular appearance of the epiphysis of the middle phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4021511	hp.json	Triangular end part of the middle bone of the pinkie finger|Triangular end part of the middle bone of the little finger|Delta-shaped epiphysis of the middle phalanx of the 5th finger|Triangular end part of the middle bone of the pinky finger	http://purl.obolibrary.org/obo/HP_0009213		
HP:0012857	biolink:PhenotypicFeature	Increased scrotal rugation	Increased number or density of the folded ridges (wrinkles) of skin of the scrotum.	UMLS:C4022706	hp.json		http://purl.obolibrary.org/obo/HP_0012857		
HP:0009216	biolink:PhenotypicFeature	Cone-shaped epiphysis of the middle phalanx of the 4th finger	A cone-shaped appearance of the epiphysis of the middle phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4024525	hp.json	Cone-shaped end part of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009216		
HP:0012858	biolink:PhenotypicFeature	Decreased scrotal rugation	Decreased number or density of the folded ridges (wrinkles) of skin of the scrotum.	UMLS:C4022705	hp.json		http://purl.obolibrary.org/obo/HP_0012858		
HP:0009215	biolink:PhenotypicFeature	Bracket epiphysis of the middle phalanx of the 4th finger	An abnormality of the middle phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024526	hp.json	Bracket shaped end part of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009215		
HP:0012859	biolink:PhenotypicFeature	Esophageal leukoplakia	A white patch or plaque occurring on the surface of the esophageal mucous membranes that cannot be rubbed off and cannot be characterized clinically as any other disease.	SNOMEDCT_US:89057003|UMLS:C0267095	hp.json	Esophageal epidermoid metaplasia	http://purl.obolibrary.org/obo/HP_0012859		
HP:0009210	biolink:PhenotypicFeature	Pseudoepiphysis of the middle phalanx of the 5th finger	A secondary ossification center in the middle phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024530	hp.json		http://purl.obolibrary.org/obo/HP_0009210		
HP:0009212	biolink:PhenotypicFeature	Stippling of the epiphysis of the middle phalanx of the 5th finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 5th finger.	UMLS:C4024528	hp.json	Speckled calcifications in end part of the middle bone of the pinkie finger|Speckled calcifications in end part of the middle bone of the little finger|Speckled calcifications in end part of the middle bone of the pinky finger	http://purl.obolibrary.org/obo/HP_0009212		
UBERON:0009027	biolink:AnatomicalEntity	vesical artery	An artery that supplies blood to the urinary bladder.	EMAPA:37131|MA:0002078	hp.json	arteria vesicali|vesical arteries	http://purl.obolibrary.org/obo/UBERON_0009027		
HP:0009211	biolink:PhenotypicFeature	Small epiphysis of the middle phalanx of the 5th finger	Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 5th finger with respect to age-dependent norms.	UMLS:C4024529	hp.json	Small end part of the middle bone of the pinkie finger|Small end part of the middle bone of the little finger|Small end part of the middle bone of the pinky finger	http://purl.obolibrary.org/obo/HP_0009211		
HP:0012840	biolink:PhenotypicFeature	Proximal	Localized close to the central point of the body.	SNOMEDCT_US:40415009|UMLS:C0205107	hp.json		http://purl.obolibrary.org/obo/HP_0012840		
HP:0012841	biolink:PhenotypicFeature	Retinal vascular tortuosity	The presence of an increased number of twists and turns of the retinal blood vessels.	UMLS:C1860475	hp.json	Tortuous retinal vessels	http://purl.obolibrary.org/obo/HP_0012841		
CHEBI:27612	biolink:ChemicalSubstance	hydantoin		KEGG:C05146|Beilstein:110598|CAS:461-72-3|PDBeChem:HYN|Gmelin:101266|CAS:461-72-3|CAS:461-72-3	hp.json	2,4-imidazolidinedione|Hydantoin|2,4(3H,5H)-imidazoledione|imidazole-2,4(3H,5H)-dione|imidazolidine-2,4-dione|Glycolylurea	http://purl.obolibrary.org/obo/CHEBI_27612		3_STAR
HP:0012842	biolink:PhenotypicFeature	Skin appendage neoplasm	A benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands.	NCIT:C3262|SNOMEDCT_US:126489007|UMLS:C0345988|SNOMEDCT_US:55681005	hp.json	Skin adnexal tumor|Skin adnexal neoplasm|Skin adnexal tumour	http://purl.obolibrary.org/obo/HP_0012842		
HP:0012843	biolink:PhenotypicFeature	Hair follicle neoplasm	An uncontrolled autonomous cell-proliferation originating in a hair follicle, which is an epidermal adnexal structures responsible for hair growth.	NCIT:C3262|UMLS:C0859920|SNOMEDCT_US:44155009	hp.json		http://purl.obolibrary.org/obo/HP_0012843		
HP:0000855	biolink:PhenotypicFeature	Insulin resistance	Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels.	MSH:D007333|SNOMEDCT_US:48606007|UMLS:C0021655	hp.json	Body fails to respond to insulin	http://purl.obolibrary.org/obo/HP_0000855		
UBERON:0010000	biolink:AnatomicalEntity	multicellular anatomical structure	An anatomical structure that has more than one cell as a part.	CARO:0010000|FBbt:00100313	hp.json	multicellular structure	http://purl.obolibrary.org/obo/UBERON_0010000		upper_level
HP:0000854	biolink:PhenotypicFeature	Thyroid adenoma	The presence of a adenoma of the thyroid gland.	MSH:D013964|SNOMEDCT_US:255034006|UMLS:C0151468|NCIT:C2855|SNOMEDCT_US:255033000	hp.json		http://purl.obolibrary.org/obo/HP_0000854		
HP:0000857	biolink:PhenotypicFeature	Neonatal insulin-dependent diabetes mellitus		UMLS:C3278636	hp.json		http://purl.obolibrary.org/obo/HP_0000857		
HP:0000859	biolink:PhenotypicFeature	Hyperaldosteronism	Overproduction of the mineralocorticoid aldosterone by the adrenal cortex.	MSH:D006929|SNOMEDCT_US:88213004|UMLS:C0020428	hp.json	Increased aldosterone production|Increased aldosterone|Mineralocorticoid excess|Elevated plasma aldosterone	http://purl.obolibrary.org/obo/HP_0000859		
HP:0000858	biolink:PhenotypicFeature	Irregular menstruation	Abnormally high variation in the amount of time between periods.	SNOMEDCT_US:80182007|UMLS:C0156404	hp.json	Irregular menses|Irregular periods|Menstrual irregularities|Menstrual irregularity	http://purl.obolibrary.org/obo/HP_0000858		
UBERON:0010001	biolink:AnatomicalEntity	cell cluster organ	A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function.	CARO:0010001|FBbt:00007229	hp.json		http://purl.obolibrary.org/obo/UBERON_0010001		upper_level
CHEBI:64600	biolink:ChemicalSubstance	C21-steroid hormone	A steroid compound with a structure based on a 21-carbon (pregnane) skeleton that acts as a hormone.		hp.json	C21-steroid hormones	http://purl.obolibrary.org/obo/CHEBI_64600		3_STAR
HP:0000851	biolink:PhenotypicFeature	Congenital hypothyroidism	A type of hypothyroidism with congenital onset.	MSH:D003409|UMLS:C0010308|SNOMEDCT_US:190268003|SNOMEDCT_US:217710005	hp.json	Underactive thyroid gland from birth|Hypothyroidism, congenital	http://purl.obolibrary.org/obo/HP_0000851		
HP:0000853	biolink:PhenotypicFeature	Goiter	An enlargement of the thyroid gland.	MSH:D006042|SNOMEDCT_US:3716002|UMLS:C0018021	hp.json	Goitre|Enlarged thyroid gland in neck|Thyroid goiter|Thyroid goitre	http://purl.obolibrary.org/obo/HP_0000853		
HP:0000852	biolink:PhenotypicFeature	Pseudohypoparathyroidism	A condition characterized by resistance to the action of parathyroid hormone, in which there is hypocalcemia, hyperphosphatemia, and (appropriately) high levels of parathyroid hormone.	UMLS:C0033806|MSH:D011547|SNOMEDCT_US:58976002	hp.json		http://purl.obolibrary.org/obo/HP_0000852		
HP:0012844	biolink:PhenotypicFeature	Trichilemmoma	A benign tumour originating from the outer root sheath of the hair follicle.	UMLS:C0334263|SNOMEDCT_US:274900003|SNOMEDCT_US:46199002	hp.json	Tricholemmoma	http://purl.obolibrary.org/obo/HP_0012844		
UBERON:0009010	biolink:AnatomicalEntity	periurethral tissue	Any portion of tissue that surrounds a urethra.	BTO:0005081	hp.json		http://purl.obolibrary.org/obo/UBERON_0009010		
HP:0012845	biolink:PhenotypicFeature	Single trichilemmoma	Presence of a unitary trichilemmoma, a benign tumour originating from the outer root sheath of the hair follicle.	UMLS:C4022710	hp.json		http://purl.obolibrary.org/obo/HP_0012845		
HP:0012846	biolink:PhenotypicFeature	Multiple trichilemmomata	Presence of multiple trichilemmomata, a benign tumour originating from the outer root sheath of the hair follicle.	UMLS:C4021063	hp.json	Multiple trichilemmomas	http://purl.obolibrary.org/obo/HP_0012846		
HP:0012847	biolink:PhenotypicFeature	Epilepsia partialis continua	Epilepsia partialis continua (also called Kojevnikov's or Kozhevnikov's epilepsia) is a type of focal motor status epilepticus characterized by repeated stereotyped simple motor manifestations such as jerks, typically of a limb or the face, recurring every few seconds or minutes for extended periods (days or years).	MSH:D017036|UMLS:C0085543|SNOMEDCT_US:241006	hp.json	Kozhevnikov's epilepsia|Epilepsia partialis continua of Kojevnikov|Kojevnikov's epilepsia	http://purl.obolibrary.org/obo/HP_0012847		
UBERON:0009014	biolink:AnatomicalEntity	lower back skin	A zone of skin that is part of a lower back.	MA:0000504|EMAPA:37281	hp.json		http://purl.obolibrary.org/obo/UBERON_0009014		organ_slim
HP:0012848	biolink:PhenotypicFeature	Small intestinal stenosis	The narrowing or partial blockage of a portion of the small intestine.	UMLS:C0151924	hp.json	Narrowing of small intestine	http://purl.obolibrary.org/obo/HP_0012848		
UBERON:0009015	biolink:AnatomicalEntity	upper back skin	A zone of skin that is part of a dorsal thoracic segment of trunk.	SCTID:304890003|MA:0000510|EMAPA:37280	hp.json		http://purl.obolibrary.org/obo/UBERON_0009015		
HP:0012849	biolink:PhenotypicFeature	Small intestinal bleeding	Bleeding from the small intestine.	UMLS:C0520561|SNOMEDCT_US:70375006	hp.json	Small intestinal hemorrhage|Small intestinal haemorrhage|Small intestinal bleeding	http://purl.obolibrary.org/obo/HP_0012849		
CHEBI:27622	biolink:ChemicalSubstance	vanillylmandelate	A hydroxy monocarboxylic acid anion that is the conjugate base of vanillylmandelic acid.	KEGG:C05584	hp.json	3-Methoxy-4-hydroxymandelate|2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetate|vanilmandelate	http://purl.obolibrary.org/obo/CHEBI_27622		3_STAR
HP:0012830	biolink:PhenotypicFeature	Position	The anatomical localization of the specified phenotypic abnormality.	UMLS:C4019252	hp.json		http://purl.obolibrary.org/obo/HP_0012830		
HP:0012831	biolink:PhenotypicFeature	Laterality	The localization with respect to the side of the body of the specified phenotypic abnormality.	SNOMEDCT_US:272741003|UMLS:C0332304	hp.json		http://purl.obolibrary.org/obo/HP_0012831		
HP:0012832	biolink:PhenotypicFeature	Bilateral	Being present on both sides of the body.	UMLS:C0238767|SNOMEDCT_US:51440002	hp.json		http://purl.obolibrary.org/obo/HP_0012832		
HP:0000866	biolink:PhenotypicFeature	Euthyroid multinodular goiter		UMLS:C1846034	hp.json	Euthyroid multinodular goitre	http://purl.obolibrary.org/obo/HP_0000866		
UBERON:0012651	biolink:AnatomicalEntity	mucosa of gastroduodenal junction	A mucosa that is part of a gastroduodenal junction.	BTO:0005415	hp.json	gastroduodenal mucosa	http://purl.obolibrary.org/obo/UBERON_0012651		
HP:0034203	biolink:PhenotypicFeature	Decreased iduronate sulfatase level	An decreased level of iduronate-2-sulfatase activity in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034203		
HP:0034202	biolink:PhenotypicFeature	Abnormal iduronate sulfatase concentration			hp.json		http://purl.obolibrary.org/obo/HP_0034202		
UBERON:0012650	biolink:AnatomicalEntity	gastroduodenal junction	An anatomical junction that connects a stomach and connects a duodenum.	FMA:17046	hp.json		http://purl.obolibrary.org/obo/UBERON_0012650		
HP:0000868	biolink:PhenotypicFeature	Decreased fertility in females		UMLS:C0151639	hp.json	Decreased fertility in females|Reduced fertility in females	http://purl.obolibrary.org/obo/HP_0000868		
HP:0034205	biolink:PhenotypicFeature	Iniencephaly	Iniencephaly is a rare neural tube defect involving dysmorphic spine and abnormal fusion of the portion of the occipital skull with the back. It results in extreme fixed head retroflexion.		hp.json		http://purl.obolibrary.org/obo/HP_0034205		
HP:0034204	biolink:PhenotypicFeature	Decreased circulating C1-esterase inhibitor concentration	Decreased concentration of C1-esterase inhibitor (C1INH) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034204		
HP:0000867	biolink:PhenotypicFeature	Secondary hyperparathyroidism	Secondary hyperparathyroidism refers to the production of higher than normal levels of parathyroid hormone in the presence of hypocalcemia.	UMLS:C0020503|SNOMEDCT_US:91478007|MSH:D006962	hp.json		http://purl.obolibrary.org/obo/HP_0000867		
HP:0000869	biolink:PhenotypicFeature	Secondary amenorrhea		UMLS:C0232940|SNOMEDCT_US:86030004	hp.json	Previous menstrual periods stop	http://purl.obolibrary.org/obo/HP_0000869		
HP:0034201	biolink:PhenotypicFeature	Increased CSF homovanillic acid concentration	Elevated concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine.		hp.json		http://purl.obolibrary.org/obo/HP_0034201		
HP:0034200	biolink:PhenotypicFeature	Abnormal CSF homovanillic acid concentration	Any deviation from the normal concentration of homovanillic acid (HVA) in the cerebrospinal fluid. HVA is a metabolite of dopamine.		hp.json		http://purl.obolibrary.org/obo/HP_0034200		
HP:0000860	biolink:PhenotypicFeature	Parathyroid hypoplasia	Developmental hypoplasia of the parathyroid gland.	UMLS:C1389851	hp.json	Underdeveloped parathyroid glands|Small parathyroid glands	http://purl.obolibrary.org/obo/HP_0000860		
HP:0034207	biolink:PhenotypicFeature	Abnormal fetal gastrointestinal system morphology	An anomlous structural finding of the fetal gastrointestinal system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.		hp.json		http://purl.obolibrary.org/obo/HP_0034207		
HP:0034206	biolink:PhenotypicFeature	Abnormal fetal central nervous system morphology	An anomlous structural finding of the fetal central nervous system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.		hp.json	Abnormal fetal CNS morphology	http://purl.obolibrary.org/obo/HP_0034206		
HP:0034209	biolink:PhenotypicFeature	Fetal subependymal hemorrhage	A type of fetal intracranial hemorrhage located in the subependymal germinal matrix below the frontal horns of the lateral ventricles in the caudothalamic notch.		hp.json	Grade I fetal intracranial hemorrhage	http://purl.obolibrary.org/obo/HP_0034209		
HP:0000864	biolink:PhenotypicFeature	Abnormality of the hypothalamus-pituitary axis	Abnormality of the pituitary gland (also known as hypophysis), which is an endocrine gland that protrudes from the bottom of the hypothalamus at the base of the brain. The pituitary gland secretes the hormones ACTH, TSH, PRL, GH, endorphins, FSH, LH, oxytocin, and antidiuretic hormone. The secretion of hormones from the anterior pituitary is under the strict control of hypothalamic hormones, and the posterior pituitary is essentially an extension of the hypothalamus, so that hypothalamus and pituitary gland may be regarded as a functional unit.	UMLS:C4025819	hp.json		http://purl.obolibrary.org/obo/HP_0000864		
HP:0034208	biolink:PhenotypicFeature	Fetal intracranial hemorrhage	Abnormal bleeding inside the skull (cranium) of a fetus.		hp.json		http://purl.obolibrary.org/obo/HP_0034208		
HP:0000863	biolink:PhenotypicFeature	Central diabetes insipidus	A form of diabetes insipidus related to a failure of vasopressin (AVP) release from the hypothalamus.	MSH:D020790|SNOMEDCT_US:45369008|UMLS:C0687720	hp.json	Neurohypophyseal diabetes insipidus	http://purl.obolibrary.org/obo/HP_0000863		
HP:0012833	biolink:PhenotypicFeature	Unilateral	Being present on only the left or only the right side of the body.	SNOMEDCT_US:66459002|UMLS:C0205092	hp.json		http://purl.obolibrary.org/obo/HP_0012833		
HP:0012834	biolink:PhenotypicFeature	Right	Being located on the right side of the body.	UMLS:C0444532|SNOMEDCT_US:264180000	hp.json	Right-sided	http://purl.obolibrary.org/obo/HP_0012834		
HP:0012835	biolink:PhenotypicFeature	Left	Being located on the left side of the body.	SNOMEDCT_US:263795004|UMLS:C0443246	hp.json	Left-sided	http://purl.obolibrary.org/obo/HP_0012835		
UBERON:0009002	biolink:AnatomicalEntity	placental membrane	The membrane separating the fetal from the maternal blood in the placenta.	UMLS:C0230984|BTO:0004196|NCIT:C34253	hp.json	placental barrier	http://purl.obolibrary.org/obo/UBERON_0009002		pheno_slim
HP:0012836	biolink:PhenotypicFeature	Spatial pattern	The pattern by which a phenotype affects one or more regions of the body.	UMLS:C4022711	hp.json		http://purl.obolibrary.org/obo/HP_0012836		
HP:0012837	biolink:PhenotypicFeature	Generalized	Affecting all regions without specificity of distribution.	UMLS:C0205246|SNOMEDCT_US:60132005	hp.json	Generalised	http://purl.obolibrary.org/obo/HP_0012837		
HP:0012838	biolink:PhenotypicFeature	Localized	Being confined or restricted to a particular location.	SNOMEDCT_US:255471002|UMLS:C0392752	hp.json	Localised|Localized	http://purl.obolibrary.org/obo/HP_0012838		
HP:0012839	biolink:PhenotypicFeature	Distal	Localized away from the central point of the body.	SNOMEDCT_US:46053002|UMLS:C0205108	hp.json	Outermost	http://purl.obolibrary.org/obo/HP_0012839		
HP:0009250	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the 4th finger	Absence of the epiphysis located at the proximal end of the distal phalanx of the 4th finger.	UMLS:C4024497	hp.json	Absent end part of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009250		
HP:0009252	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the 4th finger	A cone-shaped appearance of the epiphysis of the distal phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4024495	hp.json	Cone-shaped end part of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009252		
HP:0009251	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the 4th finger	An abnormality of the distal phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024496	hp.json	Bracket shaped end part of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009251		
UBERON:0010061	biolink:AnatomicalEntity	lumen of nasopharynx		FMA:55094	hp.json	nasopharynx lumen|nasopharynx cavity|nasopharyngeal luman	http://purl.obolibrary.org/obo/UBERON_0010061		
UBERON:0010062	biolink:AnatomicalEntity	pharyngotympanic tube epithelium		EMAPA:32801|EHDAA2:0004117|FMA:285217|MA:0003142	hp.json	eustachian tube epithelium|auditory tube epithelium	http://purl.obolibrary.org/obo/UBERON_0010062		
UBERON:0010060	biolink:AnatomicalEntity	pharyngeal opening of pharyngotympanic tube	On the lateral wall of the nasal part of the pharynx is the pharyngeal opening of auditory tube (pharyngeal ostium), somewhat triangular in shape, and bounded behind by a firm prominence, the torus or cushion, caused by the medial end of the cartilage of the tube which elevates the mucous membrane.	FMA:54979	hp.json	pharyngeal ostium of pharyngotympanic tube|ostium pharyngeum tubae auditoriae|pharyngeal opening of eustachian tube|pharyngeal orifice of eustachian tube|ostium pharyngeum tubae auditivae|ostium pharyngeum tubae auditivae|pharyngeal ostium|pharyngeal ostium of auditory tube|pharyngeal orifice of pharyngotympanic tube|pharyngeal opening of auditory tube|pharyngeal ostium of eustachian tube|pharyngeal tubal ostium|pharyngeal orifice of auditory tube	http://purl.obolibrary.org/obo/UBERON_0010060		
HP:0010247	biolink:PhenotypicFeature	Bracket epiphyses of the distal phalanges of the hand	An abnormality of the distal phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4023952	hp.json	Bracket shaped end part of the outermost hand bones	http://purl.obolibrary.org/obo/HP_0010247		
UBERON:0010065	biolink:AnatomicalEntity	auditory meatus epithelium		EHDAA2:0004114	hp.json		http://purl.obolibrary.org/obo/UBERON_0010065		
HP:0010246	biolink:PhenotypicFeature	Absent epiphyses of the distal phalanges of the hand		UMLS:C4023953	hp.json	Absent end part of the outermost hand bones	http://purl.obolibrary.org/obo/HP_0010246		
HP:0010245	biolink:PhenotypicFeature	Abnormality of the epiphyses of the proximal phalanges of the hand		UMLS:C4023954	hp.json	Abnormality of the end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010245		
UBERON:0010063	biolink:AnatomicalEntity	tympanic cavity epithelium		EHDAA2:0004116	hp.json		http://purl.obolibrary.org/obo/UBERON_0010063		
UBERON:0010064	biolink:AnatomicalEntity	open anatomical space	An anatomical space with at least one opening to another space or the exterior.	AEO:0000221|EHDAA2:0004616	hp.json		http://purl.obolibrary.org/obo/UBERON_0010064		
HP:0010244	biolink:PhenotypicFeature	Abnormality of the epiphyses of the middle phalanges of the hand		UMLS:C4023955	hp.json	Abnormality of the end part of the middle hand bones	http://purl.obolibrary.org/obo/HP_0010244		
UBERON:0010069	biolink:AnatomicalEntity	outer epithelial layer of tympanic membrane	A portion of the external acoustic meatus epithelium which makes up the outer (cuticular) layer of the tympanic membrane.	FMA:56819	hp.json	tympanic membrane external acoustic meatus epithelial component|outer layer of tympanic membrane|cuticular stratum of tympanic membrane|outer cuticular layer of tympanic membrane|cuticular layer of tympanic membrane	http://purl.obolibrary.org/obo/UBERON_0010069		
HP:0010243	biolink:PhenotypicFeature	Abnormality of the epiphyses of the distal phalanx of finger	Any anomaly of distal epiphysis of phalanx of finger.	UMLS:C4023956	hp.json	Abnormality of the end part of the outermost bone of finger	http://purl.obolibrary.org/obo/HP_0010243		
HP:0010242	biolink:PhenotypicFeature	Aplasia of the proximal phalanges of the hand		UMLS:C4021302	hp.json	Absent innermost bones|Absent proximal phalanges	http://purl.obolibrary.org/obo/HP_0010242		
HP:0010241	biolink:PhenotypicFeature	Short proximal phalanx of finger	Congenital hypoplasia of one or more proximal phalanx of finger.	UMLS:C1860606	hp.json	Short proximal phalanx of finger|Short innermost finger bones|Shortening in proximal phalanges|Hypoplasia of the proximal phalanges of the hand|Short proximal phalanges	http://purl.obolibrary.org/obo/HP_0010241		
CHEBI:64628	biolink:ChemicalSubstance	somatostatin	A fourteen-membered heterodetic cyclic peptide comprising the sequence Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys cyclised by a disulfide bridge between the two Cys residues at positions 3 and 14.	PMID:22251942|LINCS:LSM-5326|CAS:38916-34-6|PMID:22483686|HMDB:HMDB0013072|CAS:38916-34-6|PMID:21922516|PMID:22509294|KEGG:C16022|KEGG:D07431|Reaxys:10148626|Wikipedia:Somatostatin|PMID:22147011|PMID:22129035|Drug_Central:2997	hp.json	Somatostatin-1|somatostatine|L-alanylglycyl-L-cysteinyl-L-lysyl-L-asparaginyl-L-phenylalanyl-L-phenylalanyl-L-tryptophyl-L-lysyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-cysteine cyclic (3-14) disulfide|somatostatina|somatostatinum|L-alanyl-N-[(4R,7S,10S,13S,16S,19S,22S,25S,28S,31S,34S,37R)-19,34-bis(4-aminobutyl)-31-(2-amino-2-oxoethyl)-13,25,28-tribenzyl-4-carboxy-10,16-bis[(1R)-1-hydroxyethyl]-7-(hydroxymethyl)-22-(1H-indol-3-ylmethyl)-6,9,12,15,18,21,24,27,30,33,36-undecaoxo-1,2-dithia-5,8,11,14,17,20,23,26,29,32,35-undecaazacyclooctatriacontan-37-yl]glycinamide|Synthetic growth hormone release-inhibiting hormone|Ala-Gly-cyclo-[Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys]|Somatostatin-14|somatostatin	http://purl.obolibrary.org/obo/CHEBI_64628		3_STAR
HP:0010249	biolink:PhenotypicFeature	Enlarged epiphyses of the distal phalanges of the hand		UMLS:C4023950	hp.json	Enlarged end part of the outermost hand bones	http://purl.obolibrary.org/obo/HP_0010249		
HP:0010248	biolink:PhenotypicFeature	Cone-shaped epiphyses of the distal phalanges of the hand		UMLS:C4023951	hp.json	Cone-shaped end part of the outermost hand bones	http://purl.obolibrary.org/obo/HP_0010248		
HP:0009247	biolink:PhenotypicFeature	Abnormality of the epiphysis of the middle phalanx of the 4th finger		UMLS:C4024500	hp.json	Abnormality of the end part of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009247		
HP:0009246	biolink:PhenotypicFeature	Aplasia of the distal phalanx of the 5th finger	Absence of the distal phalanx of the little (5th) finger.	UMLS:C4024501	hp.json	Absent outermost little finger bone|Absent outermost pinkie finger bone|Absent outermost pinky finger bone	http://purl.obolibrary.org/obo/HP_0009246		
HP:0009249	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the 4th finger		UMLS:C4024498	hp.json	Abnormality of the end part of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009249		
HP:0009248	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the 4th finger		UMLS:C4024499	hp.json	Abnormality of the end part of the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009248		
HP:0009243	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the 5th finger	Patchy increase in bone density of the distal phalanx of the 5th finger.	UMLS:C4024503	hp.json	Uneven increase in bone density in the outermost bone of pinkie finger|Uneven increase in bone density in the outermost bone of pinky finger|Uneven increase in bone density in the outermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009243		
HP:0009242	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanx of the 5th finger	Dissolution or degeneration of bone tissue of the distal phalanx of the 5th finger.	UMLS:C4024504	hp.json		http://purl.obolibrary.org/obo/HP_0009242		
HP:0009245	biolink:PhenotypicFeature	Triangular shaped distal phalanx of the 5th finger	Triangular shaped distal phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024502	hp.json	Triangular shaped outermost pinky finger bone|Triangular shaped outermost little finger bone|Triangular shaped outermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009245		
HP:0009244	biolink:PhenotypicFeature	Distal/middle symphalangism of 5th finger	Fusion of the terminal/distal and middle phalanges of the 5th finger.	UMLS:C1868573|UMLS:C4020781	hp.json	Fused end and middle bones of little finger|Symphalangism of the terminal and middle phalanges of the 5th finger|Fusion of the terminal and middle phalanges of the 5th finger|Fifth finger distal interphalangeal joint symphalangism|Symphalangism of the distal and middle phalanges of the 5th finger|Fused end and middle bones of pinkie finger|Fused end and middle bones of pinky finger	http://purl.obolibrary.org/obo/HP_0009244		
HP:0012891	biolink:PhenotypicFeature	High posterior hairline	Hair on the neck extends less inferiorly than usual.	UMLS:C4022692	hp.json	High hairline at back of head	http://purl.obolibrary.org/obo/HP_0012891		
HP:0009261	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the 4th finger	Absence of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger.	UMLS:C4024487	hp.json	Absent end part of the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009261		
HP:0012892	biolink:PhenotypicFeature	Facial muscle hypertrophy	Hypertrophy of one or more muscles innervated by the facial nerve (the seventh cranial nerve).	UMLS:C4280307|UMLS:C4022691	hp.json	Increased size of facial muscles|Hyperplasia of facial muscles|Large facial muscles	http://purl.obolibrary.org/obo/HP_0012892		
HP:0009260	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the 4th finger	A triangular appearance of the epiphysis of the distal phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4021507	hp.json	Delta-shaped epiphysis of the distal phalanx of the 4th finger|Triangular end part of the outermost bone of ring finger	http://purl.obolibrary.org/obo/HP_0009260		
HP:0009263	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the 4th finger	A cone-shaped appearance of the epiphysis of the proximal phalanx of the ring finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4024486	hp.json	Cone-shaped end part of the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009263		
HP:0012893	biolink:PhenotypicFeature	Neck muscle hypertrophy	Muscle hypertrophy affecting the muscles of the neck.	UMLS:C4280306|UMLS:C4022690	hp.json	Large neck muscles|Overgrowth of neck muscles|Hypertrophy of cervical muscles|Increased size of neck muscles|Hyperplasia of neck muscles	http://purl.obolibrary.org/obo/HP_0012893		
HP:0009262	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the 4th finger	An abnormality of the proximal phalanx of the fourth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4021506	hp.json	Bracket shaped end part of the innermost bone of the ring finger|Bracket proximal epiphysis of the ring finger	http://purl.obolibrary.org/obo/HP_0009262		
HP:0012894	biolink:PhenotypicFeature	Paraspinal muscle hypertrophy	Muscle hypertrophy affecting the paraspinal muscles.	UMLS:C4022689	hp.json		http://purl.obolibrary.org/obo/HP_0012894		
HP:0012895	biolink:PhenotypicFeature	Scapular muscle hypertrophy	Muscle hypertrophy affecting the scapular muscles.	UMLS:C4022688	hp.json		http://purl.obolibrary.org/obo/HP_0012895		
CHEBI:76619	biolink:ChemicalSubstance	omega-methyl fatty acid anion	A fatty acid anion obtained by deprotonation of the carboxy group of any omega-methyl fatty acid; major species at pH 7.3.		hp.json	an omega-methyl fatty acid	http://purl.obolibrary.org/obo/CHEBI_76619		3_STAR
HP:0012896	biolink:PhenotypicFeature	Abnormal motor evoked potentials	An anomaly identified by motor evoked potentials (MEPs). MEPs are measured following single-pulse or repetitive transcranial magnetic stimulation and can be used for the assessment of the excitability of the motor cortex and the integrity of conduction along the central and peripheral motor pathways.	UMLS:C4022687	hp.json		http://purl.obolibrary.org/obo/HP_0012896		
HP:0012897	biolink:PhenotypicFeature	Abnormal upper-limb motor evoked potentials	An anomaly identified by motor evoked potentials (MEPs) in the arm.	UMLS:C4021059	hp.json	Abnormal motor evoked potentials in the upper limb	http://purl.obolibrary.org/obo/HP_0012897		
HP:0012898	biolink:PhenotypicFeature	Abnormal lower-limb motor evoked potentials	An anomaly identified by motor evoked potentials (MEPs) in the leg.	UMLS:C4021058	hp.json	Abnormal motor evoked potentials in the lower limb	http://purl.obolibrary.org/obo/HP_0012898		
HP:0010236	biolink:PhenotypicFeature	Small epiphyses of the phalanges of the hand	Abnormally small size of the epiphyses of the phalanges of the fingers with respect to age-dependent norms.	UMLS:C4021305	hp.json	Small epiphyses of the fingers|Small end part of finger bones	http://purl.obolibrary.org/obo/HP_0010236		
UBERON:0010054	biolink:AnatomicalEntity	malleus cartilage element	A malleus endochondral element that is composed primarily of cartilage tissue.	EMAPA:18229	hp.json		http://purl.obolibrary.org/obo/UBERON_0010054		
HP:0010235	biolink:PhenotypicFeature	Pseudoepiphyses of the phalanges of the hand	A secondary ossification center in the phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4021306	hp.json	Pseudoepiphysis of the fingers	http://purl.obolibrary.org/obo/HP_0010235		
UBERON:0010055	biolink:AnatomicalEntity	stapes cartilage element	A stapes endochondral element that is composed primarily of cartilage tissue.	EMAPA:18230	hp.json		http://purl.obolibrary.org/obo/UBERON_0010055		
HP:0010234	biolink:PhenotypicFeature	Ivory epiphyses of the phalanges of the hand	Sclerosis of the epiphyses of the phalanges of the fingers, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C1857651	hp.json	Ivory epiphyses of the fingers|Increased bone density of end part of the hand bones|Sclerotic ivory phalangeal epiphyses	http://purl.obolibrary.org/obo/HP_0010234		
UBERON:0010052	biolink:AnatomicalEntity	mucosa of dorsum of tongue	A mucosa that is part of a dorsum of tongue.	SCTID:245835003|FMA:74871	hp.json	mucosa of dorsal surface of tongue	http://purl.obolibrary.org/obo/UBERON_0010052		
HP:0010233	biolink:PhenotypicFeature	Irregular epiphyses of the phalanges of the hand	Irregular radiographic opacity of the epiphyses of the phalanges of the fingers.	UMLS:C4021307	hp.json	Irregular epiphyses of the fingers|Irregular end part of finger bones	http://purl.obolibrary.org/obo/HP_0010233		
HP:0010232	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the phalanges of the hand	Fragmented appearance of the epiphyses of the phalanges of the fingers.	UMLS:C4021308	hp.json	Fragmentation of end part of finger bones|Fragmentation of the epiphyses of the fingers	http://purl.obolibrary.org/obo/HP_0010232		
UBERON:0010059	biolink:AnatomicalEntity	hypoglossal cord		EHDAA2:0004610	hp.json		http://purl.obolibrary.org/obo/UBERON_0010059		
HP:0010231	biolink:PhenotypicFeature	Enlarged epiphyses of the phalanges of the hand	Abnormally large size of the epiphyses of the phalanges of the fingers with respect to age-dependent norms.	UMLS:C1865036	hp.json	Enlarged phalangeal epiphyses|Enlarged epiphyses of the fingers|Enlarged end part of finger bones	http://purl.obolibrary.org/obo/HP_0010231		
HP:0010230	biolink:PhenotypicFeature	Cone-shaped epiphyses of the phalanges of the hand	A cone-shaped appearance of the epiphyses of the fingers of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.	UMLS:C1859480	hp.json	Conical phalangeal epiphyses|Coned epiphyses of hands|Cone-shaped epiphyses of the fingers|Cone-shaped end part of finger bones|Cone-shaped epiphyses of hand	http://purl.obolibrary.org/obo/HP_0010230		
UBERON:0010056	biolink:AnatomicalEntity	future tongue	A compound organ that has the potential to develop into a tongue.	EHDAA:2951|EHDAA2:0000696	hp.json		http://purl.obolibrary.org/obo/UBERON_0010056		
HP:0012890	biolink:PhenotypicFeature	Posteriorly placed anus	Posterior malposition of the anus.	UMLS:C4022693	hp.json		http://purl.obolibrary.org/obo/HP_0012890		
HP:0010239	biolink:PhenotypicFeature	Aplasia of the middle phalanx of the hand	Absence of one or more middle phalanx of a finger.	UMLS:C1862096	hp.json	Missing middle phalanges|Absent middle phalanges|Absent middle bones of hand	http://purl.obolibrary.org/obo/HP_0010239		
HP:0010238	biolink:PhenotypicFeature	Triangular epiphyses of the phalanges of the hand	A triangular appearance of the epiphyses of the phalanges of the fingers of the hand.	UMLS:C4021303	hp.json	Triangular epiphyses of the fingers|Delta-shaped epiphyses of the fingers|Triangular end part of finger bones	http://purl.obolibrary.org/obo/HP_0010238		
HP:0010237	biolink:PhenotypicFeature	Epiphyseal stippling of finger phalanges	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of phalanges of the fingers.	UMLS:C4021304	hp.json	Speckled calcifications in end part of finger bones|Stippling of the epiphyses of the phalanges of the hand|Stippling of the epiphyses of the fingers	http://purl.obolibrary.org/obo/HP_0010237		
HP:0009258	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the 4th finger	Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 4th finger with respect to age-dependent norms.	UMLS:C4024489	hp.json	Small end part of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009258		
HP:0012899	biolink:PhenotypicFeature	Handgrip myotonia	Difficulty releasing one's grip associated with prolonged first handgrip relaxation times.	UMLS:C1868623	hp.json	Grip myotonia	http://purl.obolibrary.org/obo/HP_0012899		
HP:0009257	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the 4th finger	A secondary ossification center in the distal phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024490	hp.json		http://purl.obolibrary.org/obo/HP_0009257		
GO:1990849	biolink:BiologicalProcess	vacuolar localization	Any process in which the vacuole is transported to, and/or maintained in, a specific location within the cell.		hp.json	maintenance of vacuolar location|maintenance of vacuolar localization|maintenance of vacuole localization|maintenance of vacuole location	http://purl.obolibrary.org/obo/GO_1990849		
HP:0009259	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the 4th finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 4th finger.	UMLS:C4024488	hp.json	Speckled calcifications in the end part of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009259		
HP:0009254	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the 4th finger	Fragmented appearance of the epiphysis of the distal phalanx of the 4th finger.	UMLS:C4024493	hp.json	Fragmentation of end part of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009254		
HP:0009253	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the 4th finger	Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 4th finger with respect to age-dependent norms.	UMLS:C4024494	hp.json	Enlarged end part of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009253		
HP:0009256	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the 4th finger	Sclerosis of the epiphysis of the distal phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024491	hp.json	Increased bone density of end part of the outermost ring finger bone	http://purl.obolibrary.org/obo/HP_0009256		
HP:0009255	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the 4th finger	Irregular radiographic opacity of the epiphysis of the distal phalanx of the 4th finger.	UMLS:C4024492	hp.json	Irregular end part of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009255		
HP:0012880	biolink:PhenotypicFeature	Abnormal labia minora morphology	An anomaly of the labia minora, the folds of skin between the outer labia.	UMLS:C4022696	hp.json	Abnormality of the labia minora|Abnormality of the inner vaginal lips	http://purl.obolibrary.org/obo/HP_0012880		
HP:0012881	biolink:PhenotypicFeature	Abnormal labia majora morphology	An anomaly of the outer labia.	UMLS:C4022695	hp.json	Abnormality of vaginal lips|Abnormality of the labia majora	http://purl.obolibrary.org/obo/HP_0012881		
HP:0012882	biolink:PhenotypicFeature	Hyperplastic labia majora	Overgrowth of the outer labia.	UMLS:C4021060	hp.json	Hyperplasia of labia majora|Enlarged labia majora	http://purl.obolibrary.org/obo/HP_0012882		
HP:0009230	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanx of the 5th finger	Dissolution or degeneration of bone tissue of the proximal phalanx of the 5th finger.	UMLS:C4024514	hp.json		http://purl.obolibrary.org/obo/HP_0009230		
HP:0012883	biolink:PhenotypicFeature	Fallopian tube cyst	A fluid filled sac located in the Fallopian tube.	SNOMEDCT_US:59401005|UMLS:C0269173	hp.json		http://purl.obolibrary.org/obo/HP_0012883		
HP:0012884	biolink:PhenotypicFeature	Fallopian tube torsion	A twisting of the Fallopian tube. Sudden onset with sharp, colicky pelvic pain associated with nausea, vomiting, bowel, and bladder symptoms is the usual presentation.	UMLS:C0269169|SNOMEDCT_US:46946009	hp.json	Twisted fallopian tube	http://purl.obolibrary.org/obo/HP_0012884		
HP:0012885	biolink:PhenotypicFeature	Fallopian tube duplication	The presence of a supernumerary Fallopian tube.	SNOMEDCT_US:48672005|UMLS:C0266375	hp.json	Accessory fallopian tube	http://purl.obolibrary.org/obo/HP_0012885		
HP:0012886	biolink:PhenotypicFeature	Hemorrhagic ovarian cyst	An abdominal mass formed by bleeding into a follicular ovarian cyst or corpus luteum cyst.	UMLS:C0473311|SNOMEDCT_US:119420007	hp.json		http://purl.obolibrary.org/obo/HP_0012886		
HP:0012887	biolink:PhenotypicFeature	Ovarian serous cystadenoma	A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue.	UMLS:C0346170|UMLS:C4020715|SNOMEDCT_US:119421006	hp.json	Serous ovarian cyst	http://purl.obolibrary.org/obo/HP_0012887		
HP:0010225	biolink:PhenotypicFeature	Pseudoepiphysis of the 4th metacarpal	The normal epiphysis of the fourth metacarpal is localised at the distal end of the metacarpal bone. This term aplies if an accesory epiphysis, located at the proximal end of the metacarpal bone, is present.	UMLS:C4023959	hp.json		http://purl.obolibrary.org/obo/HP_0010225		
HP:0010224	biolink:PhenotypicFeature	Abnormality of the epiphysis of the 4th metacarpal	Any abnormality of the epiphysis of the 4th metacarpal bone.	UMLS:C4023960	hp.json	Abnormality of the end part of the 4th long bone of hand	http://purl.obolibrary.org/obo/HP_0010224		
HP:0010223	biolink:PhenotypicFeature	Pseudoepiphysis of the 3rd metacarpal	The normal epiphysis of the third metacarpal is localised at the distal end of the metacarpal bone. This term aplies if an accesory epiphysis, located at the proximal end of the metacarpal bone, is present.	UMLS:C4023961	hp.json		http://purl.obolibrary.org/obo/HP_0010223		
HP:0010222	biolink:PhenotypicFeature	Abnormality of the epiphysis of the 3rd metacarpal	Any abnormality of the epiphysis of the third metacarpal bone.	UMLS:C4023962	hp.json	Abnormality of the end part of the 3rd long bone of hand	http://purl.obolibrary.org/obo/HP_0010222		
UBERON:0010042	biolink:AnatomicalEntity	1st arch mesenchyme	Mesenchyme that is part of a pharyngeal arch 1.	EMAPA:16128	hp.json	mesenchyme of 1st arch	http://purl.obolibrary.org/obo/UBERON_0010042		
UBERON:0010047	biolink:AnatomicalEntity	oral gland	Gland of the epithelium lining the oral cavity. The most common are the salivary glands.	EMAPA:16723|VHOG:0000652|EHDAA:2181|EHDAA2:0001327|EMAPA:16572	hp.json	gland of oral region|oral cavity gland|buccal gland|mouth gland|oral region gland|gland of oral opening	http://purl.obolibrary.org/obo/UBERON_0010047		
HP:0010221	biolink:PhenotypicFeature	obsolete Pseudoepiphysis of the 2nd metacarpal			hp.json		http://purl.obolibrary.org/obo/HP_0010221		
HP:0010220	biolink:PhenotypicFeature	Abnormality of the epiphysis of the 2nd metacarpal	Any abnormality of the epiphysis of the second metacarpal bone.	UMLS:C4023964	hp.json	Abnormality of the end part of the 2nd long bone of hand	http://purl.obolibrary.org/obo/HP_0010220		
UBERON:0010045	biolink:AnatomicalEntity	1st arch maxillary mesenchyme	Mesenchyme that is part of a 1st arch maxillary component.	EMAPA:16391|EHDAA2:0000041	hp.json	maxillary component mesenchyme|maxillary mesenchyme|mesenchyme of maxillary component	http://purl.obolibrary.org/obo/UBERON_0010045		
UBERON:0010046	biolink:AnatomicalEntity	entire pharyngeal arch associated mesenchyme	The sum total of mesenchymal tissue in the pharyngeal arch region. Pharyngeal mesenchyme is undifferentiated, loose connective tissue derived mostly from mesoderm, and also contains ectodermally derived neural crest cells.	XAO:0004524|EHDAA2:0001459|EMAPA:16550	hp.json	associated mesenchyme of pharyngeal region|entire branchial arch associated mesenchyme|pharyngeal arch associated mesenchyme|entire branchial arch associated mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010046		
HP:0000891	biolink:PhenotypicFeature	Cervical ribs		UMLS:C0158779|SNOMEDCT_US:72535009|MSH:D057070	hp.json		http://purl.obolibrary.org/obo/HP_0000891		hposlim_core
HP:0000890	biolink:PhenotypicFeature	Long clavicles	Increased length of the clavicles.	SNOMEDCT_US:249687007|UMLS:C0426808	hp.json	Long collarbone|Elongated clavicles	http://purl.obolibrary.org/obo/HP_0000890		
HP:0000893	biolink:PhenotypicFeature	Bulging of the costochondral junction	Abnormal outward curving (protuberance) of the junction of ribs and costal cartilage.	UMLS:C1848538	hp.json		http://purl.obolibrary.org/obo/HP_0000893		
UBERON:0010039	biolink:AnatomicalEntity	food storage organ	An organ of the digestive tract that is capable of retaining and storing food.	TGMA:0001041|BSA:0000123|TADS:0000172	hp.json		http://purl.obolibrary.org/obo/UBERON_0010039		functional_classification|grouping_class
HP:0000892	biolink:PhenotypicFeature	Bifid ribs	A bifid rib refers to cleavage of the sternal end of a rib, usually unilateral. Bifid ribs are usually asymptomatic, and are often discovered incidentally by chest x-ray.	UMLS:C4721788	hp.json	Split ribs|Cleft ribs	http://purl.obolibrary.org/obo/HP_0000892		
HP:0010229	biolink:PhenotypicFeature	Bracket epiphyses of the phalanges of the hand	Bracket epiphysis refers to an abnormality in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4021309	hp.json	Bracket epiphyses of the fingers|Bracket shaped end part of finger bones	http://purl.obolibrary.org/obo/HP_0010229		
HP:0009229	biolink:PhenotypicFeature	Curved proximal phalanx of the 5th finger	Curved appearance of the proximal phalanx of the 5th finger.	UMLS:C4024515	hp.json	Curved innermost bone of pinkie finger|Curved innermost bone of pinky finger|Curved innermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009229		
HP:0000895	biolink:PhenotypicFeature	Lateral clavicle hook	An excessive upward convexity of the lateral clavicle.	SNOMEDCT_US:249684000|UMLS:C0426805	hp.json	Hooked clavicle|Hook-shaped collarbone|Handlebar clavicle|Hook-shaped clavicle	http://purl.obolibrary.org/obo/HP_0000895		
HP:0000894	biolink:PhenotypicFeature	Short clavicles	Reduced length of the clavicles.	UMLS:C0426799|SNOMEDCT_US:93250003	hp.json	Hypoplastic clavicles|Short collarbone|Underdeveloped clavicles|Clavicular hypoplasia	http://purl.obolibrary.org/obo/HP_0000894		hposlim_core
HP:0009228	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the 5th finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 5th finger is affected.	UMLS:C4024516	hp.json	Bullet-shaped innermost little finger bone|Bullet-shaped innermost pinkie finger bone|Bullet-shaped innermost pinky finger bone	http://purl.obolibrary.org/obo/HP_0009228		
HP:0010228	biolink:PhenotypicFeature	Absent epiphyses of the phalanges of the hand	Absence of one or more epiphyses of the phalanges of the fingers.	UMLS:C4021310	hp.json	Absent end part of fingers|Absent epiphyses of the fingers	http://purl.obolibrary.org/obo/HP_0010228		
HP:0010227	biolink:PhenotypicFeature	Pseudoepiphysis of the 5th metacarpal	The normal epiphysis of the fifth metacarpal is localised at the distal end of the metacarpal bone. This term aplies if an accesory epiphysis, located at the proximal end of the metacarpal bone, is present.	UMLS:C4023957	hp.json		http://purl.obolibrary.org/obo/HP_0010227		
HP:0000897	biolink:PhenotypicFeature	Rachitic rosary	A row of beadlike prominences at the junction of a rib and its cartilage (i.e., enlarged costochondral joints), resembling a rosary.	SNOMEDCT_US:249702007|SNOMEDCT_US:15214001	hp.json		http://purl.obolibrary.org/obo/HP_0000897		
HP:0010226	biolink:PhenotypicFeature	Abnormality of the epiphysis of the 5th metacarpal	Any abnormality of the epiphysis of the fifth metacarpal bone.	UMLS:C4023958	hp.json	Abnormality of the end part of the long bone of pinky finger|Abnormality of the end part of the long bone of pinkie finger|Abnormality of the end part of the long bone of little finger	http://purl.obolibrary.org/obo/HP_0010226		
HP:0000896	biolink:PhenotypicFeature	Rib exostoses	Multiple circumscribed bony excrescences located in the ribs.	UMLS:C1835579	hp.json		http://purl.obolibrary.org/obo/HP_0000896		
HP:0009225	biolink:PhenotypicFeature	Aplasia of the proximal phalanx of the 5th finger	Absence of the proximal phalanx of the little (5th) finger.	UMLS:C4024517	hp.json	Absent innermost bone of pinky finger|Absent innermost bone of pinkie finger|Absent innermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009225		
HP:0012888	biolink:PhenotypicFeature	Abnormal uterine cervix morphology	An anomaly of the neck of the uterus (lower part of the uterus), called the uterine cervix.	UMLS:C4022694	hp.json	Abnormality of the uterine cervix	http://purl.obolibrary.org/obo/HP_0012888		
HP:0012889	biolink:PhenotypicFeature	Cervical endometriosis	Abnormal growth of endometrial cells (which are normally limited to the uterus) within the cervix.	UMLS:C0269107|SNOMEDCT_US:61640006	hp.json		http://purl.obolibrary.org/obo/HP_0012889		
HP:0009224	biolink:PhenotypicFeature	Triangular epiphysis of the middle phalanx of the 4th finger	A triangular appearance of the epiphysis of the middle phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4021510	hp.json	Triangular end part of the middle bone of the ring finger|Delta-shaped epiphysis of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009224		
HP:0009227	biolink:PhenotypicFeature	Broad proximal phalanx of the 5th finger	Increased width of the proximal phalanx of the 5th finger.	UMLS:C4021508	hp.json	Broad innermost pinkie finger bone|Wide proximal phalanx of the 5th finger|Broad innermost pinky finger bone|Broad innermost little finger bone	http://purl.obolibrary.org/obo/HP_0009227		
HP:0009226	biolink:PhenotypicFeature	Short proximal phalanx of the 5th finger	Hypoplastic/small proximal phalanx of the fifth finger.	UMLS:C4021509	hp.json	Short proximal phalanx of the fifth finger|Short innermost little finger bone|Hypoplastic/small proximal phalanx of the 5th finger|Short innermost pinkie finger bone|Short innermost pinky finger bone	http://purl.obolibrary.org/obo/HP_0009226		
HP:0009221	biolink:PhenotypicFeature	Pseudoepiphysis of the middle phalanx of the 4th finger	A secondary ossification center in the middle phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024520	hp.json		http://purl.obolibrary.org/obo/HP_0009221		
HP:0009220	biolink:PhenotypicFeature	Ivory epiphysis of the middle phalanx of the 4th finger	Sclerosis of the epiphysis of the middle phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024521	hp.json	Increased bone density of end part of the middle ring finger bone	http://purl.obolibrary.org/obo/HP_0009220		
HP:0009223	biolink:PhenotypicFeature	Stippling of the epiphysis of the middle phalanx of the 4th finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 4th finger.	UMLS:C4024518	hp.json	Speckled calcifications in end part of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009223		
HP:0009222	biolink:PhenotypicFeature	Small epiphysis of the middle phalanx of the 4th finger	Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 4th finger with respect to age-dependent norms.	UMLS:C4024519	hp.json	Small end part of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009222		
HP:0012870	biolink:PhenotypicFeature	Vanishing testis	A condition which is considered to be due to the subsequent atrophy and disappearance in fetal life of an initially normal testis. In the presence of spermatic cord structures is evidence of the presence of the testis in early intrauterine life. When associated with a blind-ending spermatic cord, this entity is named as his absence of a testis in an otherwise normal 46XY male is usually unilateral and is assumed to be a consequence of intrauterine or perinatal torsion or infarction.	UMLS:C0266427|SNOMEDCT_US:53599007|MSH:C537770	hp.json	Testicular regression syndrome|Vanishing testis	http://purl.obolibrary.org/obo/HP_0012870		
HP:0009241	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the 5th finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 5th finger is affected.	UMLS:C4024505	hp.json	Bullet-shaped outermost pinky finger bone|Bullet-shaped outermost little finger bone|Bullet-shaped outermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009241		
HP:0012871	biolink:PhenotypicFeature	Varicocele	A varicocele is a widening of the veins along the spermatic cord, leading to enlarged, twisted veins in the scrotum, and manifested clinically by a painless testicle lump, scrotal swelling, or bulge in the scrotum.	SNOMEDCT_US:46871008|SNOMEDCT_US:51070004|UMLS:C0042341|MSH:D014646	hp.json	Vaginal varicocele	http://purl.obolibrary.org/obo/HP_0012871		
HP:0012872	biolink:PhenotypicFeature	Abnormal vas deferens morphology	A structural anomaly of the secretory duct of the testicle that carries spermatozoa from the epididymis to the prostatic urethra where it terminates to form ejaculatory duct.	UMLS:C4022697	hp.json		http://purl.obolibrary.org/obo/HP_0012872		
HP:0009240	biolink:PhenotypicFeature	Broad distal phalanx of the 5th finger	Increased width of the distal phalanx of the 5th finger.	UMLS:C4024506	hp.json	Broad outermost little finger bone|Wide outermost pinky finger bone|Broad outermost pinky finger bone|Broad outermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009240		
HP:0012873	biolink:PhenotypicFeature	Absent vas deferens	Aplasia (congenital absence) of the vas deferens.	UMLS:C0266444|SNOMEDCT_US:5286009|SNOMEDCT_US:702610009|SNOMEDCT_US:300506000	hp.json	Absent deferent duct|Absent ductus deferens|Congenital absence of the vas deferens	http://purl.obolibrary.org/obo/HP_0012873		
HP:0012874	biolink:PhenotypicFeature	Abnormal male reproductive system physiology	An abnormal functionality of the male genital system.	UMLS:C4020716	hp.json	Abnormal male genital system physiology	http://purl.obolibrary.org/obo/HP_0012874		
HP:0012875	biolink:PhenotypicFeature	Abnormal ejaculation	Abnormality in the process of ejection of semen (usually carrying sperm) from the male reproductive tract.	UMLS:C2937350|SNOMEDCT_US:386674000	hp.json		http://purl.obolibrary.org/obo/HP_0012875		
HP:0012876	biolink:PhenotypicFeature	Premature ejaculation	The emission of semen and seminal fluid during the act of preparation for sexual intercourse, i.e. before there is penetration, or shortly after penetration.	SNOMEDCT_US:44001008|UMLS:C0033038|MSH:D061686	hp.json	Premature ejaculation	http://purl.obolibrary.org/obo/HP_0012876		
UBERON:0009042	biolink:AnatomicalEntity	prostatic venous plexus	The prostatic veins form a well-marked prostatic plexus which lies partly in the fascial sheath of the prostate and partly between the sheath and the prostatic capsule. It communicates with the pudendal and vesical plexuses.	FMA:29711	hp.json	pudendal venous plexus|plexus venosus prostaticus	http://purl.obolibrary.org/obo/UBERON_0009042		
UBERON:0010032	biolink:AnatomicalEntity	anterior part of tongue	The portion of the tongue in front of the terminal sulcus. At the apex, thin and narrow, it is directed forward against the lingual surfaces of the lower incisor teeth. It is derived primarily from the first pharyngeal arch.	NCIT:C32130|FMA:229084|UMLS:C0226946|EMAPA:37437|Wikipedia:Anterior_tongue	hp.json	anterior two thirds of the tongue|anterior 2/3 of the tongue|pars anterior dorsi linguae|buccal part of the tongue|oral part of the tongue|front of the tongue|apex linguae|apex of the tongue|anterior two thirds of the tongue|pars anterior dorsi linguae|oral part of the tongue|buccal part of the tongue|anterior 2/3 of tongue|anterior 2/3 of the tongue|apex of the tongue|apex linguae|anterior 2/3 of tongue|front of the tongue	http://purl.obolibrary.org/obo/UBERON_0010032		
HP:0010214	biolink:PhenotypicFeature	Contracture of the interphalangeal joint of the hallux	The interphalangeal joint of the big toe cannot be straightened actively or passively.	UMLS:C4023967	hp.json		http://purl.obolibrary.org/obo/HP_0010214		
UBERON:0010033	biolink:AnatomicalEntity	posterior part of tongue	The Posterior tongue, or pharyngeal part, is the part of the tongue behind the terminal sulcus. At its root, it is directed backward, and connected with the hyoid bone by the Hyoglossi and Genioglossi muscles and the hyoglossal membrane; with the epiglottis by three folds (glossoepiglottic) of mucous membrane; with the soft palate by the glossopalatine arches; and with the pharynx by the Constrictores pharyngis superiores and the mucous membrane. It is derived primarily from the third pharyngeal arch. (The second arch has a substantial contribution during fetal development, but this later atrophies. The fourth arch may also contribute, depending upon how the boundaries of the tongue are defined.).	FMA:54645|MA:0003031|UMLS:C0226958|NCIT:C12228|EMAPA:37438	hp.json	posterior part of dorsum of tongue|posterior 1/3 of the tongue|pars postsulcalis (dorsum linguae)|base of the tongue|pharyngeal part of tongue|pars posterior (dorsum linguae)|postsulcal part of dorsum of tongue|pharyngeal portion of dorsum of tongue|pharyngeal part of the tongue|radix linguae|pars posterior linguae|pars posterior dorsi linguae|posterior third of tongue|base of tongue	http://purl.obolibrary.org/obo/UBERON_0010033		
HP:0010213	biolink:PhenotypicFeature	Contracture of the tarsometatarsal joint of the hallux	Chronic loss of joint motion in the tarsometatarsal joint of the hallux due to structural changes in non-bony tissue. The tarsometatarsal joints of the feet are also called Lisfranc's joints.	UMLS:C4023968	hp.json		http://purl.obolibrary.org/obo/HP_0010213		
HP:0010212	biolink:PhenotypicFeature	Flexion contracture of the hallux	One or more bent (flexed) joints of the first (big) toe that cannot be straightened actively or passively.	UMLS:C4021311	hp.json	Joint contracture of the hallux|Joint contracture of the big toe	http://purl.obolibrary.org/obo/HP_0010212		
UBERON:0010031	biolink:AnatomicalEntity	6th arch mesenchyme	Mesenchyme that is part of a pharyngeal arch 6.	EMAPA:32765|EHDAA2:0004076|FMA:318209	hp.json	6th pharyngeal arch mesenchyme|pharyngeal arch 6 mesenchyme|6th branchial arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010031		
HP:0010211	biolink:PhenotypicFeature	Duplication of proximal phalanx of toe	Partial/complete duplication of a proximal phalanx of toe.	UMLS:C4021312	hp.json	Partial/complete duplication of the proximal phalanges of the toes|Duplication of innermost toe bones	http://purl.obolibrary.org/obo/HP_0010211		
HP:0010210	biolink:PhenotypicFeature	Triangular shaped proximal phalanges of the toes		UMLS:C4023969	hp.json	Triangular shaped innermost toe bones	http://purl.obolibrary.org/obo/HP_0010210		
UBERON:0010027	biolink:AnatomicalEntity	dorsal part of pharyngeal pouch 4			hp.json	dorsal pharyngeal pouch 4 endoderm|dorsal 4th branchial pouch|dorsal branchial pouch 4 endoderm|dorsal pharyngeal pouch 4	http://purl.obolibrary.org/obo/UBERON_0010027		
UBERON:0010028	biolink:AnatomicalEntity	ventral part of pharyngeal pouch 4			hp.json	ventral 4th branchial pouch|ventral pharyngeal pouch 4 endoderm|ventral branchial pouch 4 endoderm|ventral pharyngeal pouch 4	http://purl.obolibrary.org/obo/UBERON_0010028		
HP:0010219	biolink:PhenotypicFeature	Structural foot deformity	A foot deformity resulting due to an abnormality affecting the bones of the foot (as well as muscle and soft tissue). In contrast if only the muscle and soft tissue are affected the term positional foot deformity applies.	UMLS:C4023965	hp.json		http://purl.obolibrary.org/obo/HP_0010219		
HP:0009239	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the 5th finger		UMLS:C4024507	hp.json	Absent/underdeveloped outermost bone of pinky finger|Absent/small outermost bone of pinkie finger|Absent/small outermost bone of little finger|Absent/small outermost bone of pinky finger	http://purl.obolibrary.org/obo/HP_0009239		
HP:0010215	biolink:PhenotypicFeature	Contractures of the metatarsophalangeal joint of the hallux	The joint between the first metatarsal and the proximal phalanx of the first (big) toe cannot be straightened actively or passively.	UMLS:C4023966	hp.json		http://purl.obolibrary.org/obo/HP_0010215		
CHEBI:15611	biolink:ChemicalSubstance	sarcosine	A N-alkylglycine that is the N-methyl derivative of glycine. It is an intermediate in the metabolic pathway of glycine.	PMID:19944746|HMDB:HMDB0000271|PMID:19577367|PMID:11272730|KEGG:C00213|CAS:107-97-1|PMID:17095900|PDBeChem:SAR|PMID:17190852|PMID:11850512|PMID:17901997|PMID:15023571|CAS:107-97-1|Gmelin:2018|CAS:107-97-1|MetaCyc:SARCOSINE|Wikipedia:Sarcosine|PMID:19619564|UM-BBD_compID:c0135|Beilstein:1699442|PMID:16154544|Reaxys:1699442|PMID:15331688|PMID:19433577	hp.json	sarcosine|MeGly|L-sarcosine|methylaminoacetic acid|N-Methylglycine|N-methylaminoacetic acid|Sarcosine|(methylamino)acetic acid|Sar|SARCOSINE|(methylamino)ethanoic acid|sarcosinic acid	http://purl.obolibrary.org/obo/CHEBI_15611		3_STAR
HP:0012877	biolink:PhenotypicFeature	Retrograde ejaculation	The emission of semen and seminal fluid into the bladder instead of through the penis during orgasm.	UMLS:C0403673|SNOMEDCT_US:50112006	hp.json		http://purl.obolibrary.org/obo/HP_0012877		
HP:0009236	biolink:PhenotypicFeature	Rhomboid or triangular shaped 5th finger proximal phalanx	Rhomboid or triangular shaped 5th (little) finger proximal phalanx.	UMLS:C4024509	hp.json	Rhomboid or triangular shaped innermost bone of pinky finger|Rhomboid or triangular shaped innermost bone of pinkie finger|Rhomboid or triangular shaped innermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009236		
HP:0012878	biolink:PhenotypicFeature	Retarded ejaculation	Difficulty of a male in achieving orgasm.	SNOMEDCT_US:15405008|UMLS:C0234047	hp.json	Delayed ejaculation	http://purl.obolibrary.org/obo/HP_0012878		
HP:0009238	biolink:PhenotypicFeature	Aplasia of the 5th finger	Absent 5th (little) finger.	UMLS:C4024508	hp.json	Absent pinkie finger|Absent pinky finger|Absent little finger	http://purl.obolibrary.org/obo/HP_0009238		
HP:0012879	biolink:PhenotypicFeature	Anejaculation	Inability to ejaculate.	SNOMEDCT_US:248782001|UMLS:C0278106|SNOMEDCT_US:42288005	hp.json	Ejaculatory incompetence	http://purl.obolibrary.org/obo/HP_0012879		
HP:0009237	biolink:PhenotypicFeature	Short 5th finger	Hypoplasia (congenital reduction in size) of the fifth finger, also known as the little finger.	UMLS:C1842878	hp.json	Short phalanges of the little finger|Hypoplastic/small 5th finger|Fifth finger brachydactyly|Hypoplastic phalanges of the little finger|Short little finger|Short fifth fingers|Short pinky finger|Short pinkie finger|Short fifth finger|Hypoplastic/small little finger|Short 5th finger	http://purl.obolibrary.org/obo/HP_0009237		
HP:0009232	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanx of the 5th finger	Fusion of the proximal phalanx of the 5th finger with another bone.	UMLS:C4024512	hp.json	Fused innermost bone of pinky finger|Fused innermost bone of pinkie finger|Fused innermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009232		
HP:0009231	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the 5th finger	Patchy increase in bone density of the proximal phalanx of the 5th finger.	UMLS:C4024513	hp.json	Uneven increase in bone density in the innermost bone of pinky finger|Uneven increase in bone density in the innermost bone of pinkie finger|Uneven increase in bone density in the innermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009231		
HP:0009234	biolink:PhenotypicFeature	Symphalangism of the proximal phalanx of the 5th finger with the 5th metacarpal	Fusion of the proximal phalanx of the 5th finger with the 5th metacarpal.	UMLS:C4024510	hp.json	Fused innermost bone of little finger with 5th long bone of hand|Fused innermost bone of pinkie finger with 5th long bone of hand|Fused innermost bone of pinky finger with 5th long bone of hand	http://purl.obolibrary.org/obo/HP_0009234		
HP:0009233	biolink:PhenotypicFeature	Triangular shaped proximal phalanx of the 5th finger	Triangular shaped proximal phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024511	hp.json	Triangular shaped innermost little finger bone|Triangular shaped innermost pinkie finger bone|Triangular shaped innermost pinky finger bone	http://purl.obolibrary.org/obo/HP_0009233		
GO:1902258	biolink:BiologicalProcess	positive regulation of apoptotic process involved in outflow tract morphogenesis	Any process that activates or increases the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.		hp.json	upregulation of apoptotic process involved in outflow tract morphogenesis|up-regulation of apoptosis involved in outflow tract morphogenesis|up regulation of apoptosis involved in outflow tract morphogenesis|positive regulation of apoptosis involved in outflow tract morphogenesis|up-regulation of apoptotic process involved in outflow tract morphogenesis|up regulation of apoptotic process involved in outflow tract morphogenesis|upregulation of apoptosis involved in outflow tract morphogenesis|activation of apoptosis involved in outflow tract morphogenesis|activation of apoptotic process involved in outflow tract morphogenesis	http://purl.obolibrary.org/obo/GO_1902258		
GO:1902256	biolink:BiologicalProcess	regulation of apoptotic process involved in outflow tract morphogenesis	Any process that modulates the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.		hp.json	regulation of apoptosis involved in outflow tract morphogenesis	http://purl.obolibrary.org/obo/GO_1902256		
GO:1902257	biolink:BiologicalProcess	negative regulation of apoptotic process involved in outflow tract morphogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.		hp.json	down regulation of apoptosis involved in outflow tract morphogenesis|down-regulation of apoptotic process involved in outflow tract morphogenesis|downregulation of apoptosis involved in outflow tract morphogenesis|down regulation of apoptotic process involved in outflow tract morphogenesis|downregulation of apoptotic process involved in outflow tract morphogenesis|inhibition of apoptosis involved in outflow tract morphogenesis|inhibition of apoptotic process involved in outflow tract morphogenesis|down-regulation of apoptosis involved in outflow tract morphogenesis|negative regulation of apoptosis involved in outflow tract morphogenesis	http://purl.obolibrary.org/obo/GO_1902257		
GO:1902262	biolink:BiologicalProcess	apoptotic process involved in blood vessel morphogenesis	Any apoptotic process that is involved in blood vessel morphogenesis.		hp.json	apoptosis involved in patterning of blood vessels|type I programmed cell death involved in patterning of blood vessels|signaling (initiator) caspase activity involved in patterning of blood vessels|apoptotic cell death involved in patterning of blood vessels|apoptotic programmed cell death involved in patterning of blood vessels|apoptotic program involved in patterning of blood vessels|programmed cell death by apoptosis involved in patterning of blood vessels	http://purl.obolibrary.org/obo/GO_1902262		
GO:0001539	biolink:BiologicalProcess	cilium or flagellum-dependent cell motility	Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.		hp.json	ciliary/flagellar motility|ciliary or bacterial-type flagellar motility	http://purl.obolibrary.org/obo/GO_0001539		gocheck_do_not_manually_annotate
HP:0000808	biolink:PhenotypicFeature	Penoscrotal hypospadias	A severe form of hypospadias in which the urethral opening is located at the junction of the penis and scrotum.	SNOMEDCT_US:204889008|UMLS:C0452147	hp.json		http://purl.obolibrary.org/obo/HP_0000808		
HP:0000807	biolink:PhenotypicFeature	Glandular hypospadias		SNOMEDCT_US:429631000124104|SNOMEDCT_US:204891000|UMLS:C0452168	hp.json		http://purl.obolibrary.org/obo/HP_0000807		
HP:0000809	biolink:PhenotypicFeature	Urinary tract atresia	Congenital absence of the normal opening of a structure of the urinary tract.	UMLS:C1389003	hp.json		http://purl.obolibrary.org/obo/HP_0000809		
HP:0000800	biolink:PhenotypicFeature	Cystic renal dysplasia		UMLS:C1834931	hp.json	Renal cystic dysplasia|Renal dysplasia, cystic|Bilateral cystic dysplasia	http://purl.obolibrary.org/obo/HP_0000800		
HP:0000802	biolink:PhenotypicFeature	Impotence	Inability to develop or maintain an erection of the penis.	MSH:D007172|SNOMEDCT_US:397803000|UMLS:C0242350	hp.json	Difficulty getting an erection|Difficulty getting a full erection	http://purl.obolibrary.org/obo/HP_0000802		
HP:0000804	biolink:PhenotypicFeature	Xanthine nephrolithiasis	The presence of xanthine-containing calculi (stones) in the kidneys.	UMLS:C1848431	hp.json	Urinary xanthine stones|Xanthine stones	http://purl.obolibrary.org/obo/HP_0000804		
HP:0000803	biolink:PhenotypicFeature	Renal cortical cysts	Cysts of the cortex of the kidney.	UMLS:C1969144	hp.json	Cortical cysts	http://purl.obolibrary.org/obo/HP_0000803		
HP:0000805	biolink:PhenotypicFeature	Enuresis	Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible.	SNOMEDCT_US:8009008|MSH:D004775|UMLS:C0014394	hp.json		http://purl.obolibrary.org/obo/HP_0000805		
GO:1902275	biolink:BiologicalProcess	regulation of chromatin organization	Any process that modulates the frequency, rate or extent of chromatin organization.		hp.json	regulation of chromatin assembly or disassembly|regulation of establishment or maintenance of chromatin architecture|regulation of chromatin organisation|regulation of chromatin modification|regulation of chromatin assembly/disassembly	http://purl.obolibrary.org/obo/GO_1902275		
PR:000036194	biolink:Protein	eukaryotic protein	A protein that is encoded in the genome of some Eukaryota.		hp.json	Eukaryota protein	http://purl.obolibrary.org/obo/PR_000036194		
GO:0001523	biolink:BiologicalProcess	retinoid metabolic process	The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.		hp.json	retinoid metabolism	http://purl.obolibrary.org/obo/GO_0001523		
NCBITaxon:376913	biolink:OrganismalEntity	Haplorrhini			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_376913		
CHEBI:25046	biolink:ChemicalSubstance	linear tetrapyrrole			hp.json		http://purl.obolibrary.org/obo/CHEBI_25046		1_STAR
CHEBI:37024	biolink:ChemicalSubstance	2-aminoadipic acid	An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.	PMID:22264337|PMID:6462455|PMID:31148|Wikipedia:Alpha-Aminoadipic_acid|HMDB:HMDB0000510|Reaxys:1724349|Beilstein:1724349|Beilstein:1773077|CAS:542-32-5	hp.json	alpha-aminoadipic acid|DL-2-Aminoadipic acid|(+/-)-2-Aminoadipic acid|2-aminoadipic acid|alpha-Aminoadipic acid|aminoadipic acid|2-aminohexanedioic acid|DL-2-Aminohexanedioic acid|Aad|DL-alpha-Aminoadipic acid	http://purl.obolibrary.org/obo/CHEBI_37024		3_STAR
GO:0001525	biolink:BiologicalProcess	angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.	Wikipedia:Angiogenesis	hp.json	blood vessel formation from pre-existing blood vessels	http://purl.obolibrary.org/obo/GO_0001525		
CHEBI:37022	biolink:ChemicalSubstance	amino-acid anion			hp.json	amino-acid anions|amino-acid anion|amino acid anions	http://purl.obolibrary.org/obo/CHEBI_37022		3_STAR
CHEBI:25017	biolink:ChemicalSubstance	leucine	A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	CAS:328-39-2|LIPID_MAPS_instance:LMFA01100048|Wikipedia:Leucine|CAS:328-39-2|KEGG:C16439|Gmelin:50203|Beilstein:636005|Reaxys:636005|PMID:17439666	hp.json	Hleu|Leuzin|(RS)-Leucine|(+-)-Leucine|2-amino-4-methylpentanoic acid|Leucin|L|Leu|leucine|DL-Leucine	http://purl.obolibrary.org/obo/CHEBI_25017		3_STAR
HP:0012820	biolink:PhenotypicFeature	Bilateral vocal cord paralysis	A loss of the ability to move the vocal fold on both sides.	UMLS:C2146481	hp.json		http://purl.obolibrary.org/obo/HP_0012820		
HP:0012821	biolink:PhenotypicFeature	Unilateral vocal cord paresis	Decreased strength of the vocal fold on one side.	UMLS:C0751577|MSH:D014826	hp.json		http://purl.obolibrary.org/obo/HP_0012821		
HP:0000833	biolink:PhenotypicFeature	obsolete Glucose intolerance			hp.json		http://purl.obolibrary.org/obo/HP_0000833		
HP:0000832	biolink:PhenotypicFeature	Primary hypothyroidism	A type of hypothyroidism that results from a defect in the thyroid gland.	SNOMEDCT_US:111566002|UMLS:C0700502	hp.json		http://purl.obolibrary.org/obo/HP_0000832		
HP:0000835	biolink:PhenotypicFeature	Adrenal hypoplasia	Developmental hypoplasia of the adrenal glands.	MSH:C538429|UMLS:C0342491|UMLS:C1846223|SNOMEDCT_US:237774001	hp.json	Hypoplastic adrenal glands|Small adrenal glands|Underdeveloped adrenal glands|Adrenal gland hypoplasia	http://purl.obolibrary.org/obo/HP_0000835		
HP:0000834	biolink:PhenotypicFeature	Abnormality of the adrenal glands	Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kindneys.	UMLS:C0001621|SNOMEDCT_US:30171000|MSH:D000307|UMLS:C4021794	hp.json	Adrenal abnormalities|Adrenal gland disease	http://purl.obolibrary.org/obo/HP_0000834		
HP:0000837	biolink:PhenotypicFeature	Increased circulating gonadotropin level	Overproduction of gonadotropins (FSH, LH) by the anterior pituitary gland.	UMLS:C1862265	hp.json	Elevated gonadotropins|Elevated serum gonadotropins|Increased circulating gonadotropin level|Gonadotropin excess	http://purl.obolibrary.org/obo/HP_0000837		
HP:0000836	biolink:PhenotypicFeature	Hyperthyroidism	An abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3).	UMLS:C0020550|MSH:D006980|SNOMEDCT_US:34486009	hp.json	Overactive thyroid	http://purl.obolibrary.org/obo/HP_0000836		
HP:0000839	biolink:PhenotypicFeature	Pituitary dwarfism	A type of reduced stature with normal proportions related to dysfunction of the pituitary gland related to either an isolated defect in the secretion of growth hormone or to panhypopituitarism, i.e., a deficit of all the anterior pituitary hormones.	UMLS:C0013338|SNOMEDCT_US:7530009|MSH:D004393|SNOMEDCT_US:367460001	hp.json		http://purl.obolibrary.org/obo/HP_0000839		
HP:0000831	biolink:PhenotypicFeature	Insulin-resistant diabetes mellitus	A type of diabetes mellitus related not to lack of insulin but rather to lack of response to insulin on the part of the target tissues of insulin such as muscle, fat, and liver cells. This type of diabetes is typically associated with increases both in blood glucose concentrations as well as in fasting and postprandial serum insulin levels.	UMLS:C0854110	hp.json	Insulin resistant diabetes mellitus|Insulin resistant diabetes|Insulin-resistant diabetes	http://purl.obolibrary.org/obo/HP_0000831		
PR:Q61391	biolink:Protein	neprilysin (mouse)	A neprilysin that is encoded in the genome of mouse.	UniProtKB:Q61391	hp.json	atriopeptidase (mouse)|skin fibroblast elastase (mouse)|NEP (mouse)|enkephalinase (mouse)|mMME|neutral endopeptidase (mouse)|SFE (mouse)|CD10 (mouse)|neutral endopeptidase 24.11 (mouse)|Mme	http://purl.obolibrary.org/obo/PR_Q61391		
HP:0000830	biolink:PhenotypicFeature	Anterior hypopituitarism	A condition of reduced function of the anterior pituitary gland characterized by decreased secretion of one or more of the pituitary hormones growth hormone, thyroid-stimulating hormone, adrenocorticotropic hormone, prolactin, luteinizing hormone, and follicle-stimulating hormone.	UMLS:C4025821	hp.json		http://purl.obolibrary.org/obo/HP_0000830		
HP:0012822	biolink:PhenotypicFeature	Bilateral vocal cord paresis	Decreased strength of the vocal fold on both sides.	UMLS:C0751574|MSH:D014826	hp.json		http://purl.obolibrary.org/obo/HP_0012822		
HP:0012823	biolink:PhenotypicFeature	Clinical modifier	This subontology is designed to provide terms to characterize and specify the phenotypic abnormalities defined in the Phenotypic abnormality subontology, with respect to severity, laterality, age of onset, and other aspects.	UMLS:C4021064	hp.json	Phenotypic modifier	http://purl.obolibrary.org/obo/HP_0012823		
HP:0012824	biolink:PhenotypicFeature	Severity	The intensity or degree of a manifestation.	SNOMEDCT_US:103370009|UMLS:C0522510	hp.json	Intensity	http://purl.obolibrary.org/obo/HP_0012824		
HP:0012825	biolink:PhenotypicFeature	Mild	Having a relatively minor degree of severity. For quantitative traits, a deviation of between two and three standard deviations from the appropriate population mean.	SNOMEDCT_US:446411000124101|UMLS:C1513302	hp.json	Mild	http://purl.obolibrary.org/obo/HP_0012825		
HP:0012826	biolink:PhenotypicFeature	Moderate	Having a medium degree of severity. For quantitative traits, a deviation of between three and four standard deviations from the appropriate population mean.	UMLS:C0205081|SNOMEDCT_US:446421000124109|SNOMEDCT_US:6736007	hp.json		http://purl.obolibrary.org/obo/HP_0012826		
HP:0012827	biolink:PhenotypicFeature	Borderline	Having a minor degree of severity that is considered to be on the boundary between the normal and the abnormal ranges. For quantitative traits, a deviation of that is less than two standard deviations from the appropriate population mean.	UMLS:C0205189	hp.json	Borderline	http://purl.obolibrary.org/obo/HP_0012827		
CHEBI:15681	biolink:ChemicalSubstance	alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide	A sialodiosylceramide consisting of the trisaccharide alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc attached to the primary hydroxy function of ceramide.	PMID:8448384|PMID:3864442|PMID:2449247|PMID:21149694|PMID:11164910|PMID:16212238|PMID:1379980|PMID:1371229|LIPID_MAPS_instance:LMSP0601AJ00|KEGG:G00108|PMID:7693874|PMID:1724444|PMID:15385432|PMID:1567198|PMID:7534889|PMID:2775195|PMID:2448252|PMID:15102521|PMID:12950986|PMID:16341241|KEGG:C04730|PMID:2303428|PMID:15546874|PMID:3392043|PMID:11093705|PMID:19364317|PMID:9375803|PMID:15939439|PMID:167132|PMID:2714813|PMID:16574813|PMID:8496625|PMID:11534772	hp.json	(Gal)1 (Glc)1 (Neu5Ac)1 (Cer)1|NeuAc-GM3|NeuAcalpha2-3Galbeta1-4Glcbeta1-1'Cer|(N-Acetylneuraminyl)-D-galactosyl-D-glucosylceramide|GM3 (NeuAc)|alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide|NeuAcalpha2->3Galbeta1->4Glc-Cer|(2S,3R,4E)-2-(acylamino)-3-hydroxyoctadec-4-en-1-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside|alpha-N-Acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide|N-Acetylneuraminyl-2,3-alpha-D-galactosyl-1,4-beta-D-glucosylceramide|Hematoside|monosialoganglioside GM3|alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramides|(Neu5Ac)GM3|alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer|Neu5Ac-alpha2->3Gal-beta1->4Glc-beta1->1'Cer|GM3|alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer|ganglioside GM3|Neu5Acalpha2->3Galbeta1->4Glcbeta-Cer	http://purl.obolibrary.org/obo/CHEBI_15681		3_STAR
HP:0012828	biolink:PhenotypicFeature	Severe	Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean.	UMLS:C0205082|SNOMEDCT_US:24484000	hp.json	Severe	http://purl.obolibrary.org/obo/HP_0012828		
HP:0012829	biolink:PhenotypicFeature	Profound	Having an extremely high degree of severity. For quantitative traits, a deviation of more than five standard deviations from the appropriate population mean.	UMLS:C0439808|SNOMEDCT_US:795002	hp.json	Profound	http://purl.obolibrary.org/obo/HP_0012829		
GO:0001501	biolink:BiologicalProcess	skeletal system development	The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).		hp.json	skeletal development	http://purl.obolibrary.org/obo/GO_0001501		
HP:0012810	biolink:PhenotypicFeature	Wide nasal base	Increased distance between the attachments of the alae nasi to the face.	UMLS:C1849667	hp.json	Broad nasal base|Wide nasal base|Increased width of base of nose|Broad base of nose|Wide base of nose|Increased width of nasal base	http://purl.obolibrary.org/obo/HP_0012810		
HP:0000843	biolink:PhenotypicFeature	Hyperparathyroidism	Excessive production of parathyroid hormone (PTH) by the parathyroid glands.	SNOMEDCT_US:66999008|UMLS:C0020502|MSH:D006961	hp.json	Elevated blood parathyroid hormone level	http://purl.obolibrary.org/obo/HP_0000843		
HP:0000846	biolink:PhenotypicFeature	Adrenal insufficiency	Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands.	MSH:D000309|SNOMEDCT_US:386584007|SNOMEDCT_US:237785004|SNOMEDCT_US:111563005|UMLS:C0001623	hp.json	Hypoadrenalism	http://purl.obolibrary.org/obo/HP_0000846		
HP:0000845	biolink:PhenotypicFeature	Elevated circulating growth hormone concentration	Acromegaly is a condition resulting from overproduction of growth hormone by the pituitary gland in persons with closed epiphyses, and consists chiefly in the enlargement of the distal parts of the body. The circumference of the skull increases, the nose becomes broad, the tongue becomes enlarged, the facial features become coarsened, the mandible grows excessively, and the teeth become separated. The fingers and toes grow chiefly in thickness.	MSH:D000172|UMLS:C0001206|MSH:C531600|SNOMEDCT_US:74107003|UMLS:C0235986	hp.json	Somatotropin excess|Growth hormone excess|Elevated circulating somatotropin concentration	http://purl.obolibrary.org/obo/HP_0000845		
HP:0000848	biolink:PhenotypicFeature	Increased circulating renin level	An increased level of renin in the blood.	UMLS:C0240783	hp.json	Increased serum renin|Elevated plasma renin|Hyperreninemia|Elevated blood renin level|Increased plasma renin	http://purl.obolibrary.org/obo/HP_0000848		
HP:0000847	biolink:PhenotypicFeature	Abnormality of renin-angiotensin system	An abnormality of the renin-angiotensin system.	UMLS:C4021793	hp.json	Abnormality of the renin-aldosterone axis	http://purl.obolibrary.org/obo/HP_0000847		
HP:0000849	biolink:PhenotypicFeature	Adrenocortical abnormality		UMLS:C4025820	hp.json		http://purl.obolibrary.org/obo/HP_0000849		
HP:0012819	biolink:PhenotypicFeature	Myocarditis	Inflammation of the myocardium.	MSH:D009205|UMLS:C0027059|SNOMEDCT_US:50920009	hp.json	Inflammation of heart muscle	http://purl.obolibrary.org/obo/HP_0012819		
CHEBI:15676	biolink:ChemicalSubstance	allantoin	An imidazolidine-2,4-dione that is 5-aminohydantoin in which a carbamoyl group is attached to the exocyclic nitrogen.	CAS:97-59-6|HMDB:HMDB0000462|PMID:11157020|CAS:97-59-6|Reaxys:83514|LINCS:LSM-5190|PMID:14619112|KNApSAcK:C00007468|Drug_Central:4268|PMID:17190852|Patent:US2158098|KEGG:C01551|KEGG:D00121|MetaCyc:ALLANTOIN|Wikipedia:Allantoin|CAS:97-59-6	hp.json	5-Ureido-2,4-imidazolidindione|allantoin|5-Ureidohydantoin|(2,5-Dioxo-4-imidazolidinyl)urea|4-ureido-2,5-imidazolidinedione|2,5-Dioxo-4-imidazolidinyl-urea|N-(2,5-Dioxo-4-imidazolidinyl)urea|Glyoxyldiureide|Allantoin|N-(2,5-dioxoimidazolidin-4-yl)urea	http://purl.obolibrary.org/obo/CHEBI_15676		3_STAR
HP:0000840	biolink:PhenotypicFeature	Adrenogenital syndrome	Adrenogenital syndrome is also known as congenital adrenal hyperplasia, which results from disorders of steroid hormone production in the adrenal glands leading to a deficiency of cortisol. The pituitary gland reacts by increased secretion of corticotropin, which in turn causes the adrenal glands to overproduce certain intermediary hormones which have testosterone-like effects.	SNOMEDCT_US:267395000|UMLS:C0302280|SNOMEDCT_US:237751000|SNOMEDCT_US:271077003|MSH:D047808	hp.json		http://purl.obolibrary.org/obo/HP_0000840		
HP:0000842	biolink:PhenotypicFeature	Hyperinsulinemia	An increased concentration of insulin in the blood.	UMLS:C0020459|SNOMEDCT_US:83469008|MSH:D006946	hp.json	Elevated insulin level	http://purl.obolibrary.org/obo/HP_0000842		
HP:0000841	biolink:PhenotypicFeature	Hyperactive renin-angiotensin system	An abnormally increased activity of the renin-angiotensin system, causing hypertension by a combination of volume excess and vasoconstrictor mechanisms.	UMLS:C1846345|UMLS:C3150267	hp.json	Increased plasma renin activity	http://purl.obolibrary.org/obo/HP_0000841		
HP:0012811	biolink:PhenotypicFeature	Wide nasal ridge	Increased width of the nasal ridge.	UMLS:C4020718	hp.json	Nasal ridge, wide|Increased width of nasal ridge|Increased width of dorsum of nose|Broad nasal ridge|Broad dorsum of nose|Wide dorsum of nose|Increased width of nasal dorsum|Broad nasal dorsum|Wide nasal dorsum|Wide nasal ridge	http://purl.obolibrary.org/obo/HP_0012811		
HP:0012812	biolink:PhenotypicFeature	Fullness of paranasal tissue	Increased bulk of tissue alongside the nose. The fullness can be caused by both bony and soft tissues.	UMLS:C4021065|UMLS:C4280309|UMLS:C4280308	hp.json	Hypertrophy of paranasal tissue|Paranasal fullness|Laterally built up nose|Thick paranasal tissue|Thick tissue around the nose|Hyperplasia of paranasal tissue|Fullness of tissue around the nose	http://purl.obolibrary.org/obo/HP_0012812		
GO:0001508	biolink:BiologicalProcess	action potential	A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.		hp.json		http://purl.obolibrary.org/obo/GO_0001508		
HP:0012813	biolink:PhenotypicFeature	Unilateral breast hypoplasia	Underdevelopment of the breast on one side only.	UMLS:C1844722	hp.json	One underdeveloped breast	http://purl.obolibrary.org/obo/HP_0012813		
HP:0012814	biolink:PhenotypicFeature	Bilateral breast hypoplasia	Underdevelopment of the breast on both sides.	UMLS:C4022716	hp.json	Two underdeveloped breasts	http://purl.obolibrary.org/obo/HP_0012814		
HP:0012815	biolink:PhenotypicFeature	Hypoplastic female external genitalia	Underdevelopment of part or all of the female external reproductive organs (which include the mons pubis, labia majora, labia minora, Bartholin glands, and clitoris).	UMLS:C4022715	hp.json	Underdeveloped female external genitalia	http://purl.obolibrary.org/obo/HP_0012815		
GO:0001503	biolink:BiologicalProcess	ossification	The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.	Wikipedia:Ossification	hp.json	bone formation|osteogenesis|bone biosynthesis	http://purl.obolibrary.org/obo/GO_0001503		
HP:0012816	biolink:PhenotypicFeature	Right ventricular noncompaction cardiomyopathy	A predominantly right ventricular variant of isolated noncompaction cardiomyopathy.	UMLS:C4022714	hp.json		http://purl.obolibrary.org/obo/HP_0012816		
HP:0012817	biolink:PhenotypicFeature	Noncompaction cardiomyopathy	A type of cardiomyopathy characterized anatomically by deep trabeculations in the ventricular wall, which define recesses communicating with the main ventricular chamber.	UMLS:C1839832	hp.json	Noncompaction of the ventricular myocardium|Spongiform cardiomyopathy	http://purl.obolibrary.org/obo/HP_0012817		
HP:0012818	biolink:PhenotypicFeature	Biventricular noncompaction cardiomyopathy	Noncompaction cardiomyopathy that affects both ventricles.	UMLS:C4022713	hp.json		http://purl.obolibrary.org/obo/HP_0012818		
HP:0000819	biolink:PhenotypicFeature	Diabetes mellitus	A group of abnormalities characterized by hyperglycemia and glucose intolerance.	MSH:D003920|SNOMEDCT_US:73211009|UMLS:C0011849	hp.json		http://purl.obolibrary.org/obo/HP_0000819		
HP:0000818	biolink:PhenotypicFeature	Abnormality of the endocrine system	An abnormality of the endocrine system.	SNOMEDCT_US:362969004|MSH:D004700|UMLS:C0014130|UMLS:C4025823	hp.json	Endocrine system disease	http://purl.obolibrary.org/obo/HP_0000818		
HP:0000811	biolink:PhenotypicFeature	Abnormal external genitalia		UMLS:C4025825	hp.json	Abnormal external genitalia	http://purl.obolibrary.org/obo/HP_0000811		
HP:0000813	biolink:PhenotypicFeature	Bicornuate uterus	The presence of a bicornuate uterus.	UMLS:C0266387|SNOMEDCT_US:31401003	hp.json	Uterus bicornis|Heart-shaped uterus|Heart shaped uterus	http://purl.obolibrary.org/obo/HP_0000813		
HP:0000812	biolink:PhenotypicFeature	Abnormal internal genitalia	An anomaly of the adnexa, uterus, and vagina (in female) or seminal tract and prostate (in male).	UMLS:C4025824	hp.json	Abnormal internal genitalia	http://purl.obolibrary.org/obo/HP_0000812		
HP:0000815	biolink:PhenotypicFeature	Hypergonadotropic hypogonadism	Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay.	UMLS:C0948896|SNOMEDCT_US:370999003|MSH:D007006	hp.json	Hypergonadotrophic hypogonadism|Primary hypogonadism	http://purl.obolibrary.org/obo/HP_0000815		
HP:0000817	biolink:PhenotypicFeature	Poor eye contact	Difficulty in looking at another person in the eye.	UMLS:C1445953|SNOMEDCT_US:412786000	hp.json	Poor eye contact	http://purl.obolibrary.org/obo/HP_0000817		
HP:0000816	biolink:PhenotypicFeature	Abnormality of Krebs cycle metabolism	An abnormality of the tricarboxylic acid cycle.	UMLS:C4021795	hp.json	Abnormality of citric acid cycle|Abnormality of the tricarboxylic cycle	http://purl.obolibrary.org/obo/HP_0000816		
UBERON:0012615	biolink:AnatomicalEntity	umbilical smooth muscle	A smooth muscle tissue that is part of a umbilical cord.	BTO:0001847	hp.json		http://purl.obolibrary.org/obo/UBERON_0012615		
HP:0012808	biolink:PhenotypicFeature	Abnormal nasal base	An anomaly of the nasal base, which can be conceived of as an imaginary line between the most lateral points of the external inferior attachments of the alae nasi to the face.	UMLS:C4022718	hp.json	Anomaly of base of nose|Deformity of base of nose|Malformation of base of nose|Anomaly of nasal base|Deformity of nasal base|Malformation of nasal base|Abnormal nasal base|Abnormality of base of nose	http://purl.obolibrary.org/obo/HP_0012808		
HP:0012809	biolink:PhenotypicFeature	Narrow nasal base	Decreased distance between the attachments of the alae nasi to the face.	UMLS:C4022717	hp.json	Decreased width of nasal base|Narrow nasal base|Thin base of nose|Narrow base of nose|Decreased width of base of nose|Thin nasal base	http://purl.obolibrary.org/obo/HP_0012809		
HP:0012800	biolink:PhenotypicFeature	Accessory cranial suture	A cranial suture that is in addition to canonical membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant.	UMLS:C4022927|UMLS:C4021067	hp.json	Supernumary fontanelle|Extra fontanelle|Supernumary cranial suture|Accessory fontanelle|Extra cranial suture	http://purl.obolibrary.org/obo/HP_0012800		
HP:0012801	biolink:PhenotypicFeature	Narrow jaw	Bigonial distance (lower facial width) more than 2 standard deviations below the mean (objective); or an apparently decreased width of the lower jaw (mandible) when viewed from the front (subjective).	UMLS:C4021066|UMLS:C4280310	hp.json	Thin lower jaw|Narrow lower face|Thin lower face|Narrow lower jaw|Narrow jaw|Narrow mandible	http://purl.obolibrary.org/obo/HP_0012801		
HP:0012802	biolink:PhenotypicFeature	Broad jaw	Bigonial distance (lower facial width) more than 2 SD above the mean (objective); or an apparently increased width of the lower jaw (mandible) when viewed from the front (subjective).	UMLS:C3281059	hp.json	Wide jaw|Broad mandible|Wide mandible|Broad jaw|Broad lower face	http://purl.obolibrary.org/obo/HP_0012802		
UBERON:0000642	biolink:AnatomicalEntity	suspensory ligament of duodenum	A thin muscle connecting the junction between the duodenum, jejunum, and duodenojejunal flexure to connective tissue surrounding the superior mesenteric artery and coeliac artery.	FMA:20509	hp.json	musculus suspensorius duodeni|ligament of Treitz|musculus suspensorius duodeni|suspensory muscle of duodenum|muscle of Treitz	http://purl.obolibrary.org/obo/UBERON_0000642		
HP:0012803	biolink:PhenotypicFeature	Anisometropia	Inequality of refractive power of the two eyes.	UMLS:C0003081|SNOMEDCT_US:3289004|MSH:D015858	hp.json		http://purl.obolibrary.org/obo/HP_0012803		
HP:0012804	biolink:PhenotypicFeature	Corneal ulceration	Disruption of the epithelial layer of the cornea with involvement of the underlying stroma.	MSH:D003320|UMLS:C0010043|SNOMEDCT_US:91514001	hp.json	Corneal ulcer|Corneal ulcerations	http://purl.obolibrary.org/obo/HP_0012804		
HP:0012805	biolink:PhenotypicFeature	Iris transillumination defect	Transmission of light through the iris as visualized upon slit lamp examination or infrared iris transillumination videography. The light passes through defects in the pigmentation of the iris.	UMLS:C1096099	hp.json		http://purl.obolibrary.org/obo/HP_0012805		
HP:0012806	biolink:PhenotypicFeature	Proboscis	A fleshy, tube-like structure usually located in the midline of the face or just to one side of the midline.	UMLS:C0687082	hp.json		http://purl.obolibrary.org/obo/HP_0012806		
HP:0012807	biolink:PhenotypicFeature	High insertion of columella	Insertion of the posterior columella superior to the nasal base.	UMLS:C4020909	hp.json	Ala lower than columella|Columella, high insertion	http://purl.obolibrary.org/obo/HP_0012807		hposlim_core
HP:0000829	biolink:PhenotypicFeature	Hypoparathyroidism	A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia.	SNOMEDCT_US:36976004|MSH:D007011|UMLS:C0020626	hp.json	Decreased parathyroid hormone secretion|Low parathyroid hormone	http://purl.obolibrary.org/obo/HP_0000829		
HP:0000822	biolink:PhenotypicFeature	Hypertension	The presence of chronic increased pressure in the systemic arterial system.	MSH:D006973|UMLS:C0497247|UMLS:C0020538|SNOMEDCT_US:24184005|SNOMEDCT_US:38341003	hp.json	High blood pressure|Systemic hypertension|Arterial hypertension	http://purl.obolibrary.org/obo/HP_0000822		
HP:0000821	biolink:PhenotypicFeature	Hypothyroidism	Deficiency of thyroid hormone.	MSH:D007037|SNOMEDCT_US:40930008|UMLS:C0020676	hp.json	Low T4|Underactive thyroid	http://purl.obolibrary.org/obo/HP_0000821		
HP:0000824	biolink:PhenotypicFeature	Decreased response to growth hormone stimulation test	Insufficient responses to growth hormone (GH) provocation tests. GH deficiency is defined as a serum peak GH concentration less than 10 ng/mL on provocation with a combination of at least two separate stimulation tests.	UMLS:C3714796|SNOMEDCT_US:2109003	hp.json	Somatotropin deficiency|Growth hormone deficiency	http://purl.obolibrary.org/obo/HP_0000824		
HP:0000823	biolink:PhenotypicFeature	Delayed puberty	Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.	SNOMEDCT_US:400003000|SNOMEDCT_US:123526007|MSH:D011628|UMLS:C0034012	hp.json	Delayed pubertal growth|Pubertal delay|Delayed puberty|Delayed pubertal development	http://purl.obolibrary.org/obo/HP_0000823		
HP:0000826	biolink:PhenotypicFeature	Precocious puberty	The onset of secondary sexual characteristics before a normal age. Although it is difficult to define normal age ranges because of the marked variation with which puberty begins in normal children, precocious puberty can be defined as the onset of puberty before the age of 8 years in girls or 9 years in boys.	SNOMEDCT_US:400179000|UMLS:C0034013|MSH:D011629|SNOMEDCT_US:123527003	hp.json	Early onset of puberty|Early puberty	http://purl.obolibrary.org/obo/HP_0000826		
HP:0000825	biolink:PhenotypicFeature	Hyperinsulinemic hypoglycemia	An increased concentration of insulin combined with a decreased concentration of glucose in the blood.	UMLS:C1864903	hp.json	Hyperinsulinaemic hypoglycaemia|Hyperinsulinemia hypoglycemia	http://purl.obolibrary.org/obo/HP_0000825		
HP:0000828	biolink:PhenotypicFeature	Abnormality of the parathyroid gland	An abnormality of the parathyroid gland.	SNOMEDCT_US:73132005|UMLS:C0030517|MSH:D010279|UMLS:C4025822	hp.json	Parathyroid disease	http://purl.obolibrary.org/obo/HP_0000828		
HP:0000820	biolink:PhenotypicFeature	Abnormality of the thyroid gland	An abnormality of the thyroid gland.	MSH:D013959|UMLS:C0040128|SNOMEDCT_US:14304000	hp.json	Thyroid disease|Thyroid abnormality|Abnormality of the thyroid gland	http://purl.obolibrary.org/obo/HP_0000820		
CHEBI:15693	biolink:ChemicalSubstance	aldose	Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals.	Wikipedia:Aldose|KEGG:C01370	hp.json	aldoses|an aldose|Aldose	http://purl.obolibrary.org/obo/CHEBI_15693		3_STAR
UBERON:4000020	biolink:AnatomicalEntity	mineralized extracellular matrix	Extracellular matrix that is mineralized.		hp.json		http://purl.obolibrary.org/obo/UBERON_4000020		
GO:1904831	biolink:BiologicalProcess	positive regulation of aortic smooth muscle cell differentiation	Any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation.		hp.json	activation of aortic smooth muscle cell differentiation|upregulation of aortic smooth muscle cell differentiation|up-regulation of aortic smooth muscle cell differentiation|up regulation of aortic smooth muscle cell differentiation	http://purl.obolibrary.org/obo/GO_1904831		
GO:1904830	biolink:BiologicalProcess	negative regulation of aortic smooth muscle cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of aortic smooth muscle cell differentiation.		hp.json	down-regulation of aortic smooth muscle cell differentiation|down regulation of aortic smooth muscle cell differentiation|inhibition of aortic smooth muscle cell differentiation|downregulation of aortic smooth muscle cell differentiation	http://purl.obolibrary.org/obo/GO_1904830		
CL:0000362	biolink:Cell	epidermal cell	An epithelial cell of the integument (the outer layer of an organism).	BTO:0001470|CALOHA:TS-0283|FMA:62411	hp.json	cell of epidermis|epithelial cell of skin	http://purl.obolibrary.org/obo/CL_0000362		
CL:0000365	biolink:Cell	animal zygote	Diploid cell produced by the fusion of sperm cell nucleus and egg cell.	FMA:72395|BTO:0000854|EHDAA2:0004546	hp.json	zygote	http://purl.obolibrary.org/obo/CL_0000365		
UBERON:4000013	biolink:AnatomicalEntity	mineralized skeletal tissue	Skeletal tissue that is mineralized.	XAO:0004039|VSAO:0000013	hp.json	mineralized tissue	http://purl.obolibrary.org/obo/UBERON_4000013		
GO:0050433	biolink:BiologicalProcess	regulation of catecholamine secretion	Any process that modulates the frequency, rate or extent of the regulated release of catecholamines.		hp.json		http://purl.obolibrary.org/obo/GO_0050433		
GO:0050432	biolink:BiologicalProcess	catecholamine secretion	The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.		hp.json		http://purl.obolibrary.org/obo/GO_0050432		
CL:0000347	biolink:Cell	scleral cell	A cell of the sclera of the eye.		hp.json		http://purl.obolibrary.org/obo/CL_0000347		
CL:0000348	biolink:Cell	choroidal cell of the eye	A cell of the choroid of the eye.		hp.json		http://purl.obolibrary.org/obo/CL_0000348		
CL:0000349	biolink:Cell	extraembryonic cell			hp.json		http://purl.obolibrary.org/obo/CL_0000349		
CL:0000359	biolink:Cell	vascular associated smooth muscle cell	A smooth muscle cell associated with the vasculature.		hp.json	vascular smooth muscle cell|VSMC	http://purl.obolibrary.org/obo/CL_0000359		
CL:0000351	biolink:Cell	trophoblast cell	A cell lining the outside of the blastocyst. After binding to the endometrium, trophoblast cells develop into two distinct layers, an inner layer of mononuclear cytotrophoblast cells and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblast cells, which form the early fetal-maternal interface.	FMA:83028	hp.json	trophoblastic cell	http://purl.obolibrary.org/obo/CL_0000351		
CL:0000352	biolink:Cell	epiblast cell	A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.		hp.json		http://purl.obolibrary.org/obo/CL_0000352		
CL:0000353	biolink:Cell	blastoderm cell	An undifferentiated cell produced by early cleavages of the fertilized egg (zygote).	FMA:72551|BTO:0001473	hp.json	blastomere	http://purl.obolibrary.org/obo/CL_0000353		
CL:0000354	biolink:Cell	blastemal cell		ncithesaurus:Blastemal_Cell	hp.json	blastema cell	http://purl.obolibrary.org/obo/CL_0000354		
CL:0000355	biolink:Cell	multi-potent skeletal muscle stem cell	A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell.	FMA:86767	hp.json		http://purl.obolibrary.org/obo/CL_0000355		
CL:0000357	biolink:Cell	stratified epithelial stem cell			hp.json		http://purl.obolibrary.org/obo/CL_0000357		
HP:0034173	biolink:PhenotypicFeature	Abnormal circulating interleukin 27 concentration	Any deviation from the normal range of the concentration of interleukin 27 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034173		
HP:0034172	biolink:PhenotypicFeature	Increased circulating interleukin 23 concentration	An abnormally increased concentration of interleukin 23 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034172		
HP:0034175	biolink:PhenotypicFeature	Increased circulating interleukin 27 concentration	An abnormally increased concentration of interleukin 27 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034175		
HP:0034174	biolink:PhenotypicFeature	Reduced circulating interleukin 27 concentration	An abnormally decreased concentration of interleukin 27 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034174		
HP:0034171	biolink:PhenotypicFeature	Reduced circulating interleukin 23 concentration	An abnormally decreased concentration of interleukin 23 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034171		
HP:0034170	biolink:PhenotypicFeature	Abnormal circulating interleukin 23 concentration	Any deviation from the normal range of the concentration of interleukin 23 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034170		
CL:0000325	biolink:Cell	stuff accumulating cell	A cell that is specialised to accumulate a particular substance(s).		hp.json		http://purl.obolibrary.org/obo/CL_0000325		_upper_level
GO:1902217	biolink:BiologicalProcess	erythrocyte apoptotic process	Any apoptotic process in an erythrocyte.		hp.json	erythrocyte apoptosis|RBC apoptosis|red blood cell apoptotic process|RBC apoptotic process|red blood cell apoptosis	http://purl.obolibrary.org/obo/GO_1902217		
CL:0000327	biolink:Cell	extracellular matrix secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000327		
CL:0000328	biolink:Cell	myelin accumulating cell			hp.json		http://purl.obolibrary.org/obo/CL_0000328		
CL:0000329	biolink:Cell	oxygen accumulating cell			hp.json		http://purl.obolibrary.org/obo/CL_0000329		
HP:0034177	biolink:PhenotypicFeature	Reduced circulating interleukin 17A concentration	An abnormally decreased concentration of interleukin 17A in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034177		
HP:0034176	biolink:PhenotypicFeature	Abnormal circulating interleukin 17A concentration	Any deviation from the normal range of the concentration of interleukin 17A in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034176		
HP:0034179	biolink:PhenotypicFeature	Vertebral artery aneurysm	Abnormal outpouching or sac-like dilatation in the wall of the vertebral artery .		hp.json		http://purl.obolibrary.org/obo/HP_0034179		
HP:0034178	biolink:PhenotypicFeature	Increased circulating interleukin 17A concentration	An abnormally increased concentration of interleukin 17A in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034178		
CL:0000322	biolink:Cell	pneumocyte	An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates.	CALOHA:TS-2168|FMA:62499|BTO:0000395	hp.json	alveolar epithelial cell|pneumonocyte	http://purl.obolibrary.org/obo/CL_0000322		
HP:0034184	biolink:PhenotypicFeature	Increased insulin like growth factor binding protein acid labile subunit concentration	An abnormally elevated concentration of insulin like growth factor binding protein acid labile subunit level in the blood circulation.		hp.json	Increased circulating IGFALS contration	http://purl.obolibrary.org/obo/HP_0034184		
HP:0034183	biolink:PhenotypicFeature	Spastic triplegia	Spastic weakness found in both lower extremities and one upper extremity.		hp.json		http://purl.obolibrary.org/obo/HP_0034183		
HP:0034186	biolink:PhenotypicFeature	Patella alta	Patella alta is a patella that rides abnormally high in relation to the femur, the femoral trochlea, or the tibia, with decreased bony stability requiring increased knee flexion angles to engage the trochlea.		hp.json		http://purl.obolibrary.org/obo/HP_0034186		
HP:0034185	biolink:PhenotypicFeature	Median pseudocleft lip	A type of mild median cleft lip in which the central tubercle of the upper lip is replaced by a mucosal cleft in the midline.		hp.json		http://purl.obolibrary.org/obo/HP_0034185		
HP:0034180	biolink:PhenotypicFeature	Fusion of the caudate and putamen	Abnormal joined appearance of the caudate and putamen with an absence of the anterior limb of the internal capsule.		hp.json		http://purl.obolibrary.org/obo/HP_0034180		
HP:0034182	biolink:PhenotypicFeature	Segmental hypoplasia of liver	Anatomically the liver is divided into right and left lobes based on the attachment of its peritoneal ligaments. This term refers to a developmental anomaly characterzied by the underdevelopment of one of the lobes of the liver. This is a rare and usually asymptomatic anomaly that can be detected incidentally on cross sectional imaging with computed tomography or magnetic resonance imaging.		hp.json		http://purl.obolibrary.org/obo/HP_0034182		
HP:0034181	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the liver	Absence or underdevelopment of the liver.		hp.json		http://purl.obolibrary.org/obo/HP_0034181		
CL:0000336	biolink:Cell	adrenal medulla chromaffin cell	A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation.	FMA:69262	hp.json	medullary chromaffin cell of adrenal gland	http://purl.obolibrary.org/obo/CL_0000336		
GO:1904888	biolink:BiologicalProcess	cranial skeletal system development	The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.		hp.json	cranial skeleton development|craniofacial development|osteocranium development|cranium development	http://purl.obolibrary.org/obo/GO_1904888		
CL:0000339	biolink:Cell	glioblast (sensu Vertebrata)	An early neural cell developing from the early ependymal cell of the neural tube.	FMA:70564	hp.json	spongioblast	http://purl.obolibrary.org/obo/CL_0000339		
HP:0034188	biolink:PhenotypicFeature	Midline liver	Position of the liver across the middle of the body instead of being in its normal position to the right of the stomach.		hp.json		http://purl.obolibrary.org/obo/HP_0034188		
GO:1902224	biolink:BiologicalProcess	ketone body metabolic process	The chemical reactions and pathways involving ketone body.		hp.json	ketone body metabolism	http://purl.obolibrary.org/obo/GO_1902224		
HP:0034187	biolink:PhenotypicFeature	Clavicular pseudarthrosis	A developmental defect in a the clavicule leading to bending and pathologic fracture, with inability to form a normal bony callus with subsequent fibrous nonunion, leading to the pseudarthrosis (or false joint).		hp.json		http://purl.obolibrary.org/obo/HP_0034187		
GO:1902221	biolink:BiologicalProcess	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process	The chemical reactions and pathways involving erythrose 4-phosphate/phosphoenolpyruvate family amino acid.		hp.json	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolism	http://purl.obolibrary.org/obo/GO_1902221		
HP:0034189	biolink:PhenotypicFeature	Anti-thyroid-stimulating hormone receptor antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against thyroid-stimulating hormone.		hp.json	TRAbs|Anti-TSH receptor antibody positivity	http://purl.obolibrary.org/obo/HP_0034189		
CL:0000333	biolink:Cell	migratory neural crest cell	A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.	FMA:86667	hp.json		http://purl.obolibrary.org/obo/CL_0000333		
CL:0000335	biolink:Cell	mesenchyme condensation cell	A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.		hp.json		http://purl.obolibrary.org/obo/CL_0000335		
HP:0034195	biolink:PhenotypicFeature	Triggered by muscle relaxant	Applies to a sign or symptom that is provoked or brought about by exposure to a muscle relaxant such as suxamethonium and mivacurium.		hp.json		http://purl.obolibrary.org/obo/HP_0034195		
HP:0034194	biolink:PhenotypicFeature	Suprabasal cleavage	Cleavage within the suprabasal cell layer of the epidermis, which lies directly above the basal layer and is composed of five to ten layers of cells.		hp.json	Blistering with suprabasal clefting	http://purl.obolibrary.org/obo/HP_0034194		
HP:0034197	biolink:PhenotypicFeature	Third trimester onset	This term refers to a phenotypic feature that was first observed prior to birth during the third trimester, which is defined as 28 weeks and zero days (28+0) of gestation and beyond.		hp.json		http://purl.obolibrary.org/obo/HP_0034197		
HP:0034196	biolink:PhenotypicFeature	Ductus venosus agenesis	A developmental defect characterized by lack of formation of the ductus venosus (a shunt that allows oxygenated blood in the umbilical vein to bypass the liver in the fetal circulation).		hp.json	Agenesis of the ductus venosus	http://purl.obolibrary.org/obo/HP_0034196		
HP:0034191	biolink:PhenotypicFeature	Elevated fetal middle cerebral artery peak systolic velocity	Increased peak systolic velocity of the fetal middle cerebral artery (MCA) as evaluated by Doppler ultrasound.		hp.json		http://purl.obolibrary.org/obo/HP_0034191		
HP:0034190	biolink:PhenotypicFeature	Abnormal fetal cardiovascular physiology	Abnormal functionality of the fetal cardiovascular system.		hp.json		http://purl.obolibrary.org/obo/HP_0034190		
HP:0034193	biolink:PhenotypicFeature	Stratum basale cleavage	Cleavage within the epidermal keratinocytes, which is the innermost layer of the epidermis and consists of proliferating cells that give rise to the outer layers of the epidermis.		hp.json	Blistering with cleavage within basal keratinocytes|Cleavage within the basal keratinocyte layer	http://purl.obolibrary.org/obo/HP_0034193		
HP:0034192	biolink:PhenotypicFeature	Pulmonary thromboembolism	Pulmonary embolism is caused by emboli, which have originated from venous thrombi, travelling to and occluding the arteries of the lung.		hp.json		http://purl.obolibrary.org/obo/HP_0034192		
CL:0000306	biolink:Cell	crystallin accumulating cell		FBbt:00004193	hp.json	lens cell	http://purl.obolibrary.org/obo/CL_0000306		
HP:0034199	biolink:PhenotypicFeature	Late first trimester onset	This term refers to a phenotypic feature that was first observed prior to birth in the first trimester during the early fetal period, which is defined as 11 0/7 to 13 6/7 weeks of gestation (inclusive).		hp.json	Early fetal onset	http://purl.obolibrary.org/obo/HP_0034199		
HP:0034198	biolink:PhenotypicFeature	Second trimester onset	This term refers to a phenotypic feature that was first observed prior to birth during the second trimester, which comprises the range of gestational ages from 14 0/7 weeks to 27 6/7 (inclusive).		hp.json		http://purl.obolibrary.org/obo/HP_0034198		
CL:0000300	biolink:Cell	gamete	A mature sexual reproductive cell having a single set of unpaired chromosomes.	CALOHA:TS-0395|FBbt:00005412|FMA:18649	hp.json	haploid germ cell|haploid nucleated cell	http://purl.obolibrary.org/obo/CL_0000300		
CL:0000319	biolink:Cell	mucus secreting cell		BTO:0003689	hp.json	mucous cell	http://purl.obolibrary.org/obo/CL_0000319		
GO:1902252	biolink:BiologicalProcess	positive regulation of erythrocyte apoptotic process	Any process that activates or increases the frequency, rate or extent of erythrocyte apoptotic process.		hp.json	up-regulation of red blood cell apoptosis|up regulation of erythrocyte apoptosis|positive regulation of red blood cell apoptotic process|up regulation of RBC apoptosis|positive regulation of erythrocyte apoptosis|positive regulation of RBC apoptosis|up-regulation of erythrocyte apoptotic process|up regulation of red blood cell apoptotic process|up-regulation of RBC apoptotic process|up-regulation of red blood cell apoptotic process|activation of red blood cell apoptotic process|upregulation of erythrocyte apoptosis|up regulation of erythrocyte apoptotic process|activation of red blood cell apoptosis|activation of erythrocyte apoptosis|activation of erythrocyte apoptotic process|up regulation of RBC apoptotic process|upregulation of RBC apoptosis|upregulation of red blood cell apoptosis|activation of RBC apoptotic process|activation of RBC apoptosis|positive regulation of RBC apoptotic process|positive regulation of red blood cell apoptosis|upregulation of erythrocyte apoptotic process|upregulation of RBC apoptotic process|upregulation of red blood cell apoptotic process|up regulation of red blood cell apoptosis|up-regulation of erythrocyte apoptosis|up-regulation of RBC apoptosis	http://purl.obolibrary.org/obo/GO_1902252		
GO:1902250	biolink:BiologicalProcess	regulation of erythrocyte apoptotic process	Any process that modulates the frequency, rate or extent of erythrocyte apoptotic process.		hp.json	regulation of red blood cell apoptosis|regulation of RBC apoptotic process|regulation of red blood cell apoptotic process|regulation of erythrocyte apoptosis|regulation of RBC apoptosis	http://purl.obolibrary.org/obo/GO_1902250		
GO:1902251	biolink:BiologicalProcess	negative regulation of erythrocyte apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of erythrocyte apoptotic process.		hp.json	downregulation of red blood cell apoptosis|downregulation of erythrocyte apoptotic process|inhibition of erythrocyte apoptotic process|inhibition of erythrocyte apoptosis|inhibition of RBC apoptosis|downregulation of RBC apoptotic process|inhibition of RBC apoptotic process|down regulation of red blood cell apoptosis|downregulation of red blood cell apoptotic process|down-regulation of erythrocyte apoptosis|negative regulation of erythrocyte apoptosis|negative regulation of red blood cell apoptosis|down-regulation of RBC apoptosis|down-regulation of red blood cell apoptosis|negative regulation of RBC apoptosis|down regulation of erythrocyte apoptosis|down regulation of red blood cell apoptotic process|down regulation of RBC apoptosis|inhibition of red blood cell apoptotic process|down-regulation of erythrocyte apoptotic process|inhibition of red blood cell apoptosis|negative regulation of RBC apoptotic process|negative regulation of red blood cell apoptotic process|down-regulation of red blood cell apoptotic process|down-regulation of RBC apoptotic process|downregulation of erythrocyte apoptosis|down regulation of erythrocyte apoptotic process|downregulation of RBC apoptosis|down regulation of RBC apoptotic process	http://purl.obolibrary.org/obo/GO_1902251		
CL:0000311	biolink:Cell	keratin accumulating cell			hp.json		http://purl.obolibrary.org/obo/CL_0000311		
CL:0000312	biolink:Cell	keratinocyte	An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.	FMA:62879|BTO:0000667|CALOHA:TS-0500	hp.json	malpighian cell|keratinized cell of epidermis	http://purl.obolibrary.org/obo/CL_0000312		
CL:0000313	biolink:Cell	serous secreting cell	Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid.	FMA:62511|BTO:0003687	hp.json	serous cell	http://purl.obolibrary.org/obo/CL_0000313		
HP:0010162	biolink:PhenotypicFeature	Absent epiphyses of the toes	Absence of the epiphyses of the phalanges of the toes.	UMLS:C4023997	hp.json	Absent end part of the toe bones	http://purl.obolibrary.org/obo/HP_0010162		
HP:0009173	biolink:PhenotypicFeature	Curved middle phalanx of the 5th finger	Curved appearance of the middle phalanx of the 5th finger.	UMLS:C4024557	hp.json	Curved middle bone of pinky finger|Curved middle bone of pinkie finger|Curved middle bone of little finger	http://purl.obolibrary.org/obo/HP_0009173		
HP:0010161	biolink:PhenotypicFeature	Abnormality of the phalanges of the toes		UMLS:C4023998	hp.json	Abnormality of the long bones of the toes	http://purl.obolibrary.org/obo/HP_0010161		
HP:0009172	biolink:PhenotypicFeature	Abnormal 4th finger phalanx morphology	Abnormality of the phalanges of the 4th (ring) finger.	UMLS:C4021516	hp.json	Abnormality of the phalanges of the ring finger|Abnormal bones of 4th finger	http://purl.obolibrary.org/obo/HP_0009172		
HP:0010160	biolink:PhenotypicFeature	Abnormality of the epiphyses of the toes		UMLS:C4023999	hp.json	Abnormality of the end part of the toe bones	http://purl.obolibrary.org/obo/HP_0010160		
HP:0034131	biolink:PhenotypicFeature	Anti-GT1b antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against T1b ganglioside.		hp.json		http://purl.obolibrary.org/obo/HP_0034131		
HP:0009175	biolink:PhenotypicFeature	Patchy sclerosis of the middle phalanx of the 5th finger	Patchy increase in bone density of the middle phalanx of the 5th finger.	UMLS:C4024555	hp.json	Uneven increase in bone density in the middle bone of the pinkie finger|Uneven increase in bone density in the middle bone of the pinky finger|Uneven increase in bone density in the middle bone of the little finger	http://purl.obolibrary.org/obo/HP_0009175		
HP:0034130	biolink:PhenotypicFeature	Anti-GT1a IgG antibody positivity	The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside.		hp.json		http://purl.obolibrary.org/obo/HP_0034130		
HP:0009174	biolink:PhenotypicFeature	Abnormality of the epiphyses of the 4th finger	Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 4th finger.	UMLS:C4024556	hp.json	Abnormality of the end part of the ring finger	http://purl.obolibrary.org/obo/HP_0009174		
HP:0009171	biolink:PhenotypicFeature	Triangular epiphyses of the metacarpals	A triangular appearance of the epiphyses of the metacarpals. Thess epiphyses are located at the distal end of the metacarpals.	UMLS:C4024558	hp.json	Triangular end part of the long bone of hand	http://purl.obolibrary.org/obo/HP_0009171		
HP:0009170	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanx of the 5th finger	Dissolution or degeneration of bone tissue of the middle phalanx of the 5th finger.	UMLS:C4024559	hp.json		http://purl.obolibrary.org/obo/HP_0009170		
HP:0034137	biolink:PhenotypicFeature	Anti-contactin-1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CNTN1.		hp.json	Anti-CNTN1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034137		
HP:0010169	biolink:PhenotypicFeature	Pseudoepiphyses of the toes		UMLS:C4023990	hp.json		http://purl.obolibrary.org/obo/HP_0010169		
HP:0034136	biolink:PhenotypicFeature	Anti-neurofascin 186 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NF186.		hp.json	Anti-NF186 antibody positivity	http://purl.obolibrary.org/obo/HP_0034136		
HP:0010168	biolink:PhenotypicFeature	Ivory epiphyses of the toes		UMLS:C4023991	hp.json	Increased bone density of end part of the toes	http://purl.obolibrary.org/obo/HP_0010168		
HP:0034139	biolink:PhenotypicFeature	Anti-SUMO-activating enzyme antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE.		hp.json	Anti-SAE antibody positivity|Anti-small ubiquitin-like modifier-1 activating enzyme antibody positivity	http://purl.obolibrary.org/obo/HP_0034139		
HP:0034138	biolink:PhenotypicFeature	Anti-contactin-associated protein 1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-contactin-associated protein 1.		hp.json	Anti-CASPR1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034138		
HP:0010167	biolink:PhenotypicFeature	Irregular epiphyses of the toes		UMLS:C4023992	hp.json	Irregular end part of the toe bones	http://purl.obolibrary.org/obo/HP_0010167		
HP:0010166	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the toes		UMLS:C4023993	hp.json	Fragmentation of the end part of the toe bones	http://purl.obolibrary.org/obo/HP_0010166		
HP:0034133	biolink:PhenotypicFeature	Anti-GM3 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM3.		hp.json		http://purl.obolibrary.org/obo/HP_0034133		
HP:0010165	biolink:PhenotypicFeature	Enlarged epiphyses of the toes		UMLS:C4023994	hp.json	Enlarged end part of the toe bones	http://purl.obolibrary.org/obo/HP_0010165		
HP:0034132	biolink:PhenotypicFeature	Anti-GM2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM2.		hp.json		http://purl.obolibrary.org/obo/HP_0034132		
HP:0034135	biolink:PhenotypicFeature	Anti-neurofascin-155 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NF155.		hp.json	Anti-NF155 antibody positivity	http://purl.obolibrary.org/obo/HP_0034135		
HP:0010164	biolink:PhenotypicFeature	Cone-shaped epiphyses of the toes		UMLS:C4023995	hp.json	Cone-shaped end part of the toe bones	http://purl.obolibrary.org/obo/HP_0010164		
HP:0010163	biolink:PhenotypicFeature	Bracket epiphyses of the toes		UMLS:C4023996	hp.json	Bracket shaped end part of the toe bones	http://purl.obolibrary.org/obo/HP_0010163		
HP:0034134	biolink:PhenotypicFeature	Anti-GM4 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside GM4.		hp.json		http://purl.obolibrary.org/obo/HP_0034134		
HP:0009169	biolink:PhenotypicFeature	Broad middle phalanx of the 5th finger	Increased width of the middle phalanx of the 5th finger.	UMLS:C4021517	hp.json	Broad middle bone of pinky finger|Broad middle bone of pinkie finger|Broad middle bone of little finger|Wide middle phalanx of the 5th finger	http://purl.obolibrary.org/obo/HP_0009169		
HP:0009166	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the 5th finger	Fragmented appearance of the epiphysis of the distal phalanx of the 5th finger.	UMLS:C4024562	hp.json	Fragmentation of end part of the outermost bone of pinky finger|Fragmentation of end part of the outermost bone of pinkie finger|Fragmentation of end part of the outermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009166		
HP:0009165	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the 5th finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 5th finger.	UMLS:C4024563	hp.json	Speckled calcifications in end part of the outermost bone of pinky finger|Speckled calcifications in end part of the outermost bone of pinkie finger|Speckled calcifications in end part of the outermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009165		
HP:0009168	biolink:PhenotypicFeature	Bullet-shaped middle phalanx of the 5th finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 5th finger is affected.	UMLS:C4024560	hp.json	Bullet-shaped middle pinkie finger bone|Bullet-shaped middle pinky finger bone|Bullet-shaped middle little finger bone	http://purl.obolibrary.org/obo/HP_0009168		
HP:0009167	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the 5th finger	Irregular radiographic opacity of the epiphysis of the distal phalanx of the 5th finger.	UMLS:C4024561	hp.json	Irregular end part of the outermost bone of pinky finger|Irregular end part of the outermost bone of pinkie finger|Irregular end part of the outermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009167		
HP:0010151	biolink:PhenotypicFeature	Cone-shaped epiphysis of the 1st metatarsal	A conical (cone-shaped) appearance of the epiphysis of the first metatarsal of the foot.	UMLS:C4024008	hp.json	Cone-shaped end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010151		
HP:0034140	biolink:PhenotypicFeature	Anti-SUMO-activating enzyme subunit 1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE 1.		hp.json		http://purl.obolibrary.org/obo/HP_0034140		
UBERON:0010090	biolink:AnatomicalEntity	future falx cerebri	A developing anatomical structure that has the potential to develop into a falx cerebri.	EHDAA2:0000608	hp.json		http://purl.obolibrary.org/obo/UBERON_0010090		
HP:0009184	biolink:PhenotypicFeature	Contracture of the distal interphalangeal joint of the 5th finger	Chronic loss of joint motion of the distal interphalangeal joint of the 5th finger due to structural changes in non-bony tissue.	UMLS:C4024551	hp.json		http://purl.obolibrary.org/obo/HP_0009184		
HP:0009183	biolink:PhenotypicFeature	Joint contracture of the 5th finger	Chronic loss of joint motion in the 5th finger due to structural changes in non-bony tissue. The term camptodactyly of the 5th finger is used if the distal and/or proximal interphalangeal joints are affected.	UMLS:C1865702	hp.json	Fifth finger camptodactyly|5th finger camptodactyly	http://purl.obolibrary.org/obo/HP_0009183		
HP:0010150	biolink:PhenotypicFeature	Bracket epiphysis of the 1st metatarsal	The epiphysis of the 1st metatarsal surrounds the diaphysis, having a bracket-like form.	UMLS:C4024009	hp.json	Bracket shaped end part of 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010150		
UBERON:0010091	biolink:AnatomicalEntity	future hindbrain meninx	A multi-tissue structure that has the potential to develop into a meninx of hindbrain.	EHDAA2:0000610	hp.json	future hindbrain meninges	http://purl.obolibrary.org/obo/UBERON_0010091		
HP:0034142	biolink:PhenotypicFeature	Anti-nuclear matrix protein-2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against NXP-2.		hp.json	Anti-MJ/NXP-2 antibody positivity|Anti-NXP-2 antibody positivity	http://purl.obolibrary.org/obo/HP_0034142		
HP:0009186	biolink:PhenotypicFeature	Contracture of the metacarpophalangeal joint of the 5th finger	Chronic loss of joint motion of the metacarpophalangeal joint of the 5th finger due to structural changes in non-bony tissue.	UMLS:C4024550	hp.json		http://purl.obolibrary.org/obo/HP_0009186		
HP:0009185	biolink:PhenotypicFeature	Contracture of the proximal interphalangeal joint of the 5th finger	Proximal interphalangeal (PIP) flexion deformity of the little finger. That is, the PIP joint of a little finger is bent (flexed) and cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement.	UMLS:C3554612	hp.json		http://purl.obolibrary.org/obo/HP_0009185		
HP:0034141	biolink:PhenotypicFeature	Anti-SUMO-activating enzyme subunit 2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SAE 2.		hp.json	Anti-SAE 2 antibody positivity	http://purl.obolibrary.org/obo/HP_0034141		
HP:0009180	biolink:PhenotypicFeature	Ulnar deviation of the 5th finger	Displacement of the 5th finger towards the ulnar side.	UMLS:C4024553	hp.json		http://purl.obolibrary.org/obo/HP_0009180		
HP:0009182	biolink:PhenotypicFeature	Triangular shaped middle phalanx of the 5th finger	Triangular shaped middle phalanx of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024552	hp.json	Triangular shaped middle little finger bone|Triangular shaped middle pinky finger bone|Triangular shaped middle pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009182		
UBERON:0010092	biolink:AnatomicalEntity	future metencephalon	A developing anatomical structure that has the potential to develop into a metencephalon.	EHDAA2:0000623	hp.json		http://purl.obolibrary.org/obo/UBERON_0010092		
HP:0010159	biolink:PhenotypicFeature	Triangular epiphysis of the 1st metatarsal		UMLS:C4024000	hp.json	Triangular end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010159		
HP:0034148	biolink:PhenotypicFeature	Anti-isoleucyl tRNA-synthetase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against isoleucyl tRNA-synthetase.		hp.json	Anti-OJ antibody positivity	http://purl.obolibrary.org/obo/HP_0034148		
HP:0010158	biolink:PhenotypicFeature	Stippling of the epiphysis of the 1st metatarsal		UMLS:C4024001	hp.json	Speckled calcifications in the end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010158		
HP:0034147	biolink:PhenotypicFeature	Anti-aminoacyl-tRNA synthetase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a tRNA synthetase enzyme.		hp.json		http://purl.obolibrary.org/obo/HP_0034147		
HP:0010157	biolink:PhenotypicFeature	Small epiphysis of the 1st metatarsal		UMLS:C4024002	hp.json	Small end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010157		
UBERON:0010096	biolink:AnatomicalEntity	future myelencephalon	A developing anatomical structure that has the potential to develop into a myelencephalon.	EHDAA2:0000640	hp.json		http://purl.obolibrary.org/obo/UBERON_0010096		
HP:0010156	biolink:PhenotypicFeature	Pseudoepiphysis of the 1st metatarsal		UMLS:C4024003	hp.json		http://purl.obolibrary.org/obo/HP_0010156		
HP:0034149	biolink:PhenotypicFeature	Anti-phenylalanyl tRNA synthetase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phenylalanyl tRNA synthetase.		hp.json	Phenylanyl-t-RNA synthetase alpha antibody positivity|Anti-Zo antibody positivity|Anti-Zo alpha antibody positivity	http://purl.obolibrary.org/obo/HP_0034149		
HP:0010155	biolink:PhenotypicFeature	Ivory epiphysis of the 1st metatarsal	The epiphysis of the 1st metatarsal appears hard and dense like ivory. An ivory epiphysis has a uniformly dense appearance on radiographs.	UMLS:C4024004	hp.json	Increased bone density of end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010155		
HP:0034144	biolink:PhenotypicFeature	Anti-hY-RNA complex antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ro60.		hp.json	Anti-Ro60 antibody positivity	http://purl.obolibrary.org/obo/HP_0034144		
CHEBI:64554	biolink:ChemicalSubstance	tryptophan zwitterion	An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of tryptophan; major species at pH 7.3.		hp.json	2-azaniumyl-3-(1H-indol-3-yl)propanoate|2-ammonio-3-(1H-indol-3-yl)propanoate	http://purl.obolibrary.org/obo/CHEBI_64554		3_STAR
HP:0034143	biolink:PhenotypicFeature	Anti-threonyl-tRNA synthetase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against threonyl-tRNA synthetase.		hp.json	Anti-PL-7 antibody positivity	http://purl.obolibrary.org/obo/HP_0034143		
HP:0010154	biolink:PhenotypicFeature	Irregular epiphysis of the 1st metatarsal		UMLS:C4024005	hp.json	Irregular end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010154		
HP:0010153	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the 1st metatarsal		UMLS:C4024006	hp.json	Fragmentation of the end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010153		
HP:0034146	biolink:PhenotypicFeature	Anti-glycyl tRNA-synthetase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glycyl tRNA-synthetase.		hp.json	Anti-EJ antibody positivity	http://purl.obolibrary.org/obo/HP_0034146		
HP:0034145	biolink:PhenotypicFeature	Anti-alanyl-tRNA synthetase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against alanyl-tRNA synthetase.		hp.json	Anti-PL-12 antibody positivity	http://purl.obolibrary.org/obo/HP_0034145		
HP:0010152	biolink:PhenotypicFeature	Enlarged epiphysis of the 1st metatarsal		UMLS:C4024007	hp.json	Enlarged end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010152		
CHEBI:64558	biolink:ChemicalSubstance	methionine zwitterion	An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of methionine; major species at pH 7.3.		hp.json	methionine|2-ammonio-4-(methylsulfanyl)butanoate|2-azaniumyl-4-(methylsulfanyl)butanoate	http://purl.obolibrary.org/obo/CHEBI_64558		3_STAR
HP:0009177	biolink:PhenotypicFeature	Proximal/middle symphalangism of 5th finger	Fusion of the proximal and middle phalanges of the 5th finger.	UMLS:C1836212	hp.json	Proximal fifth finger symphalangism|Proximal 5th finger symphalangism|Fused innermost and middle bones of pinky finger|Symphalangism of the proximal and middle phalanges of the 5th finger|Fused innermost and middle bones of pinkie finger|Fused innermost and middle bones of little finger	http://purl.obolibrary.org/obo/HP_0009177		
HP:0009179	biolink:PhenotypicFeature	Deviation of the 5th finger	Displacement of the 5th finger from its normal position.	UMLS:C4021515	hp.json	Displaced pinkie finger|Displaced little finger|Displaced pinky finger|Laterally displaced fifth finger	http://purl.obolibrary.org/obo/HP_0009179		
HP:0009178	biolink:PhenotypicFeature	Symphalangism of middle phalanx of 5th finger	Fusion of the middle phalanx of the 5th finger with another bone.	UMLS:C4024554	hp.json	Fused middle bones of pinky finger|Fused middle bones of pinkie finger|Fused middle bones of little finger	http://purl.obolibrary.org/obo/HP_0009178		
HP:0034151	biolink:PhenotypicFeature	Anti-asparaginyl-tRNA synthetase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against asparaginyl-tRNA synthetase.		hp.json	Anti-KS antibody positivity	http://purl.obolibrary.org/obo/HP_0034151		
HP:0010140	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the hallux		UMLS:C4024019	hp.json	Cone-shaped end part of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010140		
HP:0034150	biolink:PhenotypicFeature	Anti-tyrosyl-tRNA synthetase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against tyrosyl-tRNA synthetase.		hp.json	Anti-Ha antibody positivity	http://purl.obolibrary.org/obo/HP_0034150		
HP:0009150	biolink:PhenotypicFeature	Abnormality of the proximal phalanx of the 5th finger	Abnormality of the proximal phalanx of the little (5th) finger.	UMLS:C4024570	hp.json	Abnormality of the innermost bone pinkie finger|Abnormality of the innermost bone pinky finger|Abnormality of the innermost bone little finger	http://purl.obolibrary.org/obo/HP_0009150		
HP:0034153	biolink:PhenotypicFeature	Anti-cytosolic-5-nucleotidase-1A antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against cytosolic-5-nucleotidase-1A (cN1A).		hp.json	Anti-cN1A antibody positivity	http://purl.obolibrary.org/obo/HP_0034153		
HP:0009153	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the 5th finger	Abnormality of the epiphysis of the proximal phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx.	UMLS:C4024568	hp.json	Abnormality of end part of the innermost bone of pinkie finger|Abnormality of end part of the innermost bone of little finger|Abnormality of end part of the innermost bone of pinky finger	http://purl.obolibrary.org/obo/HP_0009153		
HP:0034152	biolink:PhenotypicFeature	Anti-histidyl tRNA synthetase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against histidyl tRNA synthetase.		hp.json	Anti-Jo-1 antibody positivity|Anti-JO1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034152		
HP:0009152	biolink:PhenotypicFeature	Abnormality of the epiphyses of the 5th finger	Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 5th finger.	UMLS:C4024569	hp.json	Abnormality of end part of little finger bone|Abnormality of end part of pinky finger bone|Abnormality of end part of pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009152		
UBERON:0010083	biolink:AnatomicalEntity	future dermis	Mesenchyme that has the potential to develop into a dermis.	EHDAA2:0000598	hp.json		http://purl.obolibrary.org/obo/UBERON_0010083		
UBERON:0010084	biolink:AnatomicalEntity	future diaphragm	A structure that will develop into a diaphragm.	EHDAA2:0000599	hp.json		http://purl.obolibrary.org/obo/UBERON_0010084		
UBERON:0010081	biolink:AnatomicalEntity	future common hepatic duct	An extrahepatic bile duct that has the potential to develop into a common hepatic duct.	EHDAA2:0000595	hp.json		http://purl.obolibrary.org/obo/UBERON_0010081		
UBERON:0009097	biolink:AnatomicalEntity	gravid organism	An organism containing a developing embryo, fetus, or unborn offspring within the body.	BTO:0004733	hp.json	pregnant stage|gravid|pregnant organism|pregnant adult|pregnant adult stage	http://purl.obolibrary.org/obo/UBERON_0009097		
HP:0010148	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the hallux		UMLS:C4024011	hp.json	Triangular end part of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010148		
HP:0034159	biolink:PhenotypicFeature	Paget disease of bone	A localized disorder of bone remodeling. Increased numbers of larger than normal osteoclasts initiate the process at affected skeletal sites, and the increase in bone resorption is followed by an increase in new bone formation, altering bone architecture.		hp.json		http://purl.obolibrary.org/obo/HP_0034159		
HP:0010147	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the hallux	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the hallux.	UMLS:C4024012	hp.json	Speckled calcifications in the end part of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010147		
HP:0034158	biolink:PhenotypicFeature	Anti-tyrosine phosphatase region of islet antigen-2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against the tyrosine phossphatase region of islet antigen 2A (this region is a specific part of IA-2). Usually IA-2A are measured using the intracellular portion of IA-2 (IA-2ic) made up of the protein tyrosine phosphatase (PTP) and juxtamembrane (JM) regions.		hp.json	Anti-PTPA antibody positivity	http://purl.obolibrary.org/obo/HP_0034158		
HP:0010146	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the hallux		UMLS:C4024013	hp.json	Small end part of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010146		
HP:0010145	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the hallux		UMLS:C4024014	hp.json		http://purl.obolibrary.org/obo/HP_0010145		
HP:0034155	biolink:PhenotypicFeature	Anti-sp100 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against sp100. Autoantibodies causing the MND pattern are directed against sp100, sp140, promyelocytic leukemia nuclear body proteins (PML) or ubiquitin-like modifier (SUMO) proteins, while in the punctate nuclear envelope pattern, the target antigens are gp210, nucleoporin-62 or laminin B receptor proteins.		hp.json		http://purl.obolibrary.org/obo/HP_0034155		
HP:0010144	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the hallux		UMLS:C4024015	hp.json	Increased bone density of end part of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010144		
HP:0010143	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the hallux		UMLS:C4024016	hp.json	Irregular end part of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010143		
HP:0034154	biolink:PhenotypicFeature	Anti-Ki antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ki.		hp.json		http://purl.obolibrary.org/obo/HP_0034154		
HP:0010142	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the hallux		UMLS:C4024017	hp.json	Fragmentation of the end part of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010142		
HP:0034157	biolink:PhenotypicFeature	Anti-beta-2-Glycoprotein I IgM antibody positivity	Presence of IgM antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome.		hp.json	Anti-beta2GPI IgM antibody positivity	http://purl.obolibrary.org/obo/HP_0034157		
HP:0010141	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the hallux		UMLS:C4024018	hp.json	Enlarged end part of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010141		
HP:0034156	biolink:PhenotypicFeature	Anti-beta-2-Glycoprotein I IgG antibody positivity	Presence of IgG antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome.		hp.json	Anti-beta2GPI IgG antibody positivity	http://purl.obolibrary.org/obo/HP_0034156		
HP:0010149	biolink:PhenotypicFeature	Absent epiphysis of the 1st metatarsal	Failure to form (agenesis) of the epiphysis of the 1st metatarsal.	UMLS:C4024010	hp.json	Absent end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010149		
HP:0009148	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the 5th finger	Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 5th finger with respect to age-dependent norms.	UMLS:C4024571	hp.json	Small end part of the outermost bone of pinkie finger|Small end part of the outermost bone of pinky finger|Small end part of the outermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009148		
UBERON:0009098	biolink:AnatomicalEntity	gravid uterus	The uterus in pregnancy.	NCIT:C12406|UMLS:C1514389|ncithesaurus:Gravid_Uterus|SCTID:362253003	hp.json	womb	http://purl.obolibrary.org/obo/UBERON_0009098		
HP:0009147	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the 5th finger	Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 5th finger with respect to age-dependent norms.	UMLS:C4024572	hp.json	Enlarged end part of the outermost bone of little finger|Enlarged end part of the outermost bone of pinky finger|Enlarged end part of the outermost bone of pinkie finger	http://purl.obolibrary.org/obo/HP_0009147		
HP:0009149	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the 5th finger	A triangular appearance of the epiphysis of the distal phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4021519	hp.json	Delta-shaped epiphysis of the distal phalanx of the 5th finger|Triangular end part of the outermost bone of pinkie finger|Triangular end part of the outermost bone of pinky finger|Triangular end part of the outermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009149		
HP:0009144	biolink:PhenotypicFeature	Supernumerary bones of the axial skeleton		UMLS:C4024573	hp.json		http://purl.obolibrary.org/obo/HP_0009144		
HP:0009145	biolink:PhenotypicFeature	Abnormal cerebral artery morphology	Any structural anomaly of a cerebral artery. The cerebral arteries comprise three main pairs of arteries and their branches, which supply the cerebrum of the brain. These are the anterior cerebral artery, the middle cerebral artery, and the posterior cerebral artery.	UMLS:C4021520	hp.json	Abnormality of cerebral artery|Abnormality of the cerebral arteries	http://purl.obolibrary.org/obo/HP_0009145		
HP:0009162	biolink:PhenotypicFeature	Absent middle phalanx of 5th finger	Absence of the middle phalanx of the little (5th) finger.	UMLS:C3277750	hp.json	Absent middle bone of little finger|Aplasia of the middle phalanx of the 5th finger|Absent middle bone of pinky finger|Absent middle bone of pinkie finger	http://purl.obolibrary.org/obo/HP_0009162		
HP:0034162	biolink:PhenotypicFeature	Abnormal circulating interleukin 10 concentration	Any deviation from the normal range of the concentration of interleukin 10 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034162		
HP:0012792	biolink:PhenotypicFeature	Absent ossification of thoracic vertebral bodies	A lack of bone mineralization of one or more body of thoracic vertebra.	UMLS:C4022721	hp.json		http://purl.obolibrary.org/obo/HP_0012792		
HP:0009161	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanx of the 5th finger	Absence or underdevelopment (hypoplasia) of the middle phalanx of the little (5th) finger.	UMLS:C1834034	hp.json	Absent/hypoplastic middle phalanx of 5th finger|Absent/underdeveloped middle bone of little finger|Absent/small middle bone of pinky finger|Absent/underdeveloped middle bone of pinky finger|Absent/underdeveloped middle bone of pinkie finger	http://purl.obolibrary.org/obo/HP_0009161		
HP:0012793	biolink:PhenotypicFeature	Kinked brainstem	A kinked appearance of the brainstem, i.e., an exaggerated flexure.	UMLS:C4021068	hp.json	Kinked brain stem	http://purl.obolibrary.org/obo/HP_0012793		
HP:0034161	biolink:PhenotypicFeature	Reduced circulating interleukin 9 concentration	An abnormally decreased concentration of interleukin 9 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034161		
HP:0009164	biolink:PhenotypicFeature	Abnormal calcification of the carpal bones		UMLS:C1968592	hp.json	Carpal calcifications|Abnormal calcification of the wrist bones	http://purl.obolibrary.org/obo/HP_0009164		
HP:0034164	biolink:PhenotypicFeature	Abnormal circulating interleukin 21 concentration	Any deviation from the normal range of the concentration of interleukin 21 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034164		
HP:0012794	biolink:PhenotypicFeature	Periventricular white matter hypodensities	Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the cerebral white matter that surrounds the cerebral ventricles.	UMLS:C4022720	hp.json	Periventricular cerebral white matter hypodensities	http://purl.obolibrary.org/obo/HP_0012794		
HP:0034163	biolink:PhenotypicFeature	Reduced circulating interleukin 10 concentration	An abnormally decreased concentration of interleukin 10 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034163		
HP:0012795	biolink:PhenotypicFeature	Abnormal optic disc morphology	A morphological abnormality of the optic disc, i.e., of the portion of the optic nerve clinically visible on fundoscopic examination.	UMLS:C3808249	hp.json		http://purl.obolibrary.org/obo/HP_0012795		
HP:0009163	biolink:PhenotypicFeature	obsolete Abnormal form of the 5th finger			hp.json		http://purl.obolibrary.org/obo/HP_0009163		
HP:0012796	biolink:PhenotypicFeature	Increased cup-to-disc ratio	An elevation in the ratio of the diameter of the cup of the optic disc to the total diameter of the disc. The optic disc has an orange-pink rim with a pale centre (the cup) that does not contain neuroretinal tissue. An increase in this ratio therefore may indicate a decrease in the quantity of healthy neuroretinal cells.	UMLS:C3805911	hp.json	Increased cup disc ratio|Elevated cup to disc ratio	http://purl.obolibrary.org/obo/HP_0012796		
HP:0012797	biolink:PhenotypicFeature	Lymphatic vessel neoplasm	A benign or malignant neoplasm arising from the lymphatic vessels.	NCIT:C3262|UMLS:C0206619|MSH:D018190|SNOMEDCT_US:115236002	hp.json	Lymphatic vessel tumor|Lymphatic vessel tumour	http://purl.obolibrary.org/obo/HP_0012797		
HP:0034160	biolink:PhenotypicFeature	Abnormal circulating interleukin 9 concentration	Any deviation from the normal range of the concentration of interleukin 9 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034160		
UBERON:0010070	biolink:AnatomicalEntity	intermediate layer of tympanic membrane	The intermediate fibrous layer of the tympanic membrane.	MA:0001223|EMAPA:19063|FMA:56830	hp.json	fibrous layer of tympanic membrane|tympanic endothelium|intermediate fibrous layer of tympanic membrane|fibrous stratum of tympanic membrane|connective tissue layer of tympanic membrane	http://purl.obolibrary.org/obo/UBERON_0010070		
HP:0009160	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the 5th finger	Absence of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger.	UMLS:C4024564	hp.json	Absent end part of the innermost bone of pinky finger|Absent end part of the innermost bone of pinkie finger|Absent end part of the innermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009160		
HP:0012798	biolink:PhenotypicFeature	Pulmonary lymphangiomyomatosis	Infiltration of smooth muscle-like cells in lymph vessels as well as the lung (pleura, alveolar septa, bronchi, pulmonary vessels and lymphatics as well as lymph nodes, especially in posterior mediastinum and retroperitoneum). Focal emphysema can develop because of airway narrowing, and the thoracic duct may be obliterated. Pulmonary lymphangiomyomatosis may lead to multiple small cysts with a hamartomatous proliferation of smooth muscle in their walls.	UMLS:C0751674|UMLS:C0238399|MSH:D018192|SNOMEDCT_US:73017001	hp.json	Pulmonary myomatosis|Lymphangioleiomyomatosis	http://purl.obolibrary.org/obo/HP_0012798		
HP:0012799	biolink:PhenotypicFeature	Unilateral facial palsy	One-sided weakness of the muscles of facial expression and eye closure.	UMLS:C4022719|UMLS:C0239516	hp.json	Unilateral facial muscle weakness|Paralysis of one side of the face|Unilateral facial muscle paralysis|Weakness of one side of the face|Facial droop|Unilateral facial weakness|Unilateral facial paralysis	http://purl.obolibrary.org/obo/HP_0012799		
UBERON:0010071	biolink:AnatomicalEntity	layer of tympanic membrane		FMA:56732	hp.json	tympanic membrane layer	http://purl.obolibrary.org/obo/UBERON_0010071		grouping_class
UBERON:0010076	biolink:AnatomicalEntity	network of trabecular spaces in bone tissue	Tissue cavity consisting of intercommunicating trabecular spaces in the cancellous bone.	FMA:259332	hp.json	trabecular network of bone tissue|trabecular space network	http://purl.obolibrary.org/obo/UBERON_0010076		
HP:0010137	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the hallux		UMLS:C4024022	hp.json	Triangular end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010137		
HP:0010136	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the hallux	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the hallux.	UMLS:C4024023	hp.json	Speckled calcifications in the end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010136		
HP:0034169	biolink:PhenotypicFeature	Increased circulating interleukin 22 concentration	An abnormally increased concentration of interleukin 22 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034169		
UBERON:0010077	biolink:AnatomicalEntity	cuboidal epithelium	An epithelium consisting of cuboidal epithelial cells.	UMLS:C0682577|NCIT:C32415|Wikipedia:Cuboidal_epithelium	hp.json		http://purl.obolibrary.org/obo/UBERON_0010077		
HP:0010135	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the hallux		UMLS:C4024024	hp.json	Small end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010135		
UBERON:0010074	biolink:AnatomicalEntity	chromaffin system	Organ system subdivision that consists primarily of chromaffin cells and their supporting structures.	FMA:79645|MESH:D002838	hp.json	argentaffin system|chromaffin tissue	http://purl.obolibrary.org/obo/UBERON_0010074		
CHEBI:64571	biolink:ChemicalSubstance	NMDA receptor agonist	An excitatory amino acid agonist which binds to NMDA receptors and triggers a response.		hp.json	NMDA receptor agonists|N-methyl-D-aspartate receptor agonist|NMDAR agonist|NMDAR agonists|N-methyl-D-aspartate receptor agonists	http://purl.obolibrary.org/obo/CHEBI_64571		3_STAR
CHEBI:64570	biolink:ChemicalSubstance	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor	An EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor that interferes with the action of glycine hydroxymethyltransferase (EC 2.1.2.1).	Wikipedia:Glycine_hydroxymethyltransferase	hp.json	threonine aldolase inhibitor|serine hydroxymethylase inhibitor|serine aldolase inhibitors|allothreonine aldolase inhibitor|5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitors|glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitor|glycine hydroxymethyltransferase (EC 2.1.2.1) inhibitors|EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitors|5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase inhibitor|allothreonine aldolase inhibitors|serine aldolase inhibitor|threonine aldolase inhibitors|serine hydroxymethylase inhibitors|L-threonine aldolase inhibitors|serine transhydroxymethylase inhibitor|EC 2.1.2.1 inhibitor|L-serine hydroxymethyltransferase inhibitors|serine hydroxymethyltransferase inhibitor|glycine hydroxymethyltransferase inhibitors|L-serine hydroxymethyltransferase inhibitor|glycine hydroxymethyltransferase inhibitor|serine hydroxymethyltransferase inhibitors|EC 2.1.2.1 inhibitors|serine transhydroxymethylase inhibitors|L-threonine aldolase inhibitor	http://purl.obolibrary.org/obo/CHEBI_64570		3_STAR
UBERON:0010075	biolink:AnatomicalEntity	sacral neural crest	One of the 5 distinct and partially overlapping functional domains of the premigratory neural crest. The vagal and sacral neural crest cells develop into the ganglia of the enteric nervous system, also known as the parasympathetic ganglia.	XAO:0004192	hp.json		http://purl.obolibrary.org/obo/UBERON_0010075		
HP:0010134	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the hallux	A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the big toe.	UMLS:C4024025	hp.json		http://purl.obolibrary.org/obo/HP_0010134		
CHEBI:64577	biolink:ChemicalSubstance	flour treatment agent	A food additive which is added to flour or dough to improve baking quality and/or colour.	Wikipedia:Flour_treatment_agent	hp.json	dough improver|improving agent|improving agents|flour treatment agent|dough improvers	http://purl.obolibrary.org/obo/CHEBI_64577		3_STAR
HP:0034166	biolink:PhenotypicFeature	Increased circulating interleukin 21 concentration	An abnormally increased concentration of interleukin 21 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034166		
HP:0010133	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the hallux		UMLS:C4024026	hp.json	Increased bone density of end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010133		
HP:0034165	biolink:PhenotypicFeature	Reduced circulating interleukin 21 concentration	An abnormally decreased concentration of interleukin 21 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034165		
HP:0010132	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the hallux		UMLS:C4024027	hp.json	Irregular end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010132		
HP:0034168	biolink:PhenotypicFeature	Reduced circulating interleukin 22 concentration	An abnormally decreased concentration of interleukin 22 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034168		
HP:0010131	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the hallux		UMLS:C4024028	hp.json	Fragmentation of the end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010131		
HP:0012790	biolink:PhenotypicFeature	Abnormal intramembranous ossification	An anomaly in the process of intramembranous ossification by which flat bones (cranial bones of the skull, i.e., the frontal, parietal, occipital, and temporal bones, and the clavicles) are formed.	UMLS:C4021069	hp.json	Abnormal intramembranous bone ossification	http://purl.obolibrary.org/obo/HP_0012790		
HP:0012791	biolink:PhenotypicFeature	Abnormal humeral ossification	An anomaly of the process of formation of bone in the humerus.	UMLS:C4022722	hp.json	Abnormal maturation of long bone in upper arm	http://purl.obolibrary.org/obo/HP_0012791		
HP:0034167	biolink:PhenotypicFeature	Abnormal circulating interleukin 22 concentration	Any deviation from the normal range of the concentration of interleukin 22 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034167		
HP:0010130	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the hallux		UMLS:C4024029	hp.json	Enlarged end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010130		
HP:0010139	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the hallux	The epiphysis of the distal phalanx of the hallux surrounds the diaphysis, having a bracket-like form.	UMLS:C4024020	hp.json	Bracket shaped end part of the outermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010139		
HP:0010138	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the hallux	Failure to form (agenesis) of the epiphysis of the distal phalanx of the hallux.	UMLS:C4024021	hp.json	Absent end part of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010138		
HP:0009159	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the 5th finger	Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger with respect to age-dependent norms.	UMLS:C4024565	hp.json	Small end part of the innermost bone of little finger|Small end part of the innermost bone of pinky finger|Small end part of the innermost bone of pinkie finger	http://purl.obolibrary.org/obo/HP_0009159		
HP:0009158	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the 5th finger	Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 5th finger with respect to age-dependent norms.	UMLS:C4024566	hp.json	Enlarged end part of the innermost bone of pinky finger|Enlarged end part of the innermost bone of pinkie finger|Enlarged end part of the innermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009158		
HP:0009155	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the 5th finger	A cone-shaped appearance of the epiphysis of the proximal phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4020784|UMLS:C4020783	hp.json	Cone-shaped end part of the innermost bone of pinkie finger|Cone-shaped end part of the innermost bone of pinky finger|Angel-shaped epiphysis of the proximal phalanx of the 5th finger|Cone-shaped end part of the innermost bone of little finger|Cone-shaped epiphysis of the proximal phalanx of the little finger	http://purl.obolibrary.org/obo/HP_0009155		
HP:0009154	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the 5th finger	A triangular appearance of the epiphysis of the proximal phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4021518	hp.json	Triangular end part of the innermost bone of little finger|Triangular end part of the innermost bone of pinky finger|Delta-shaped epiphysis of the proximal phalanx of the 5th finger|Triangular end part of the innermost bone of pinkie finger	http://purl.obolibrary.org/obo/HP_0009154		
HP:0009157	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the 5th finger	Sclerosis of the epiphysis of the proximal phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024567|UMLS:C4020782	hp.json	Ivory epiphysis of the proximal phalanx of the little finger|Increased bone density of end part of the innermost bone of pinkie finger|Increased bone density of end part of the innermost bone of pinky finger|Increased bone density of end part of the innermost bone of little finger	http://purl.obolibrary.org/obo/HP_0009157		
UBERON:6000002	biolink:AnatomicalEntity	arthropod tagma	One of the main divisions of the whole organism of arthropods formed from groups of segments.	FBbt:00000002	hp.json		http://purl.obolibrary.org/obo/UBERON_6000002		
CHEBI:64584	biolink:ChemicalSubstance	uremic toxin	A toxin that accumulates in patients with chronic kidney disease.	Wikipedia:Uremic_toxin	hp.json	uremic toxins	http://purl.obolibrary.org/obo/CHEBI_64584		3_STAR
CHEBI:64583	biolink:ChemicalSubstance	sphingomyelin			hp.json		http://purl.obolibrary.org/obo/CHEBI_64583		
CHEBI:64588	biolink:ChemicalSubstance	glycine transporter 1 inhibitor	Any glycine transporter inhibitor that interferes with the action of glycine 1 transporters.	PMID:21141920|PMID:18758757|PMID:17504107|PMID:20678516|PMID:21531289|Wikipedia:Glycine_transporter_1|PMID:22177408	hp.json	GlyT1 inhibitor|GlyT1 inhibitors|glycine transporter 1 inhibitors	http://purl.obolibrary.org/obo/CHEBI_64588		3_STAR
UBERON:6000004	biolink:AnatomicalEntity	panarthropod head		FBbt:00000004	hp.json		http://purl.obolibrary.org/obo/UBERON_6000004		
CHEBI:64589	biolink:ChemicalSubstance	glycine receptor agonist	An agonist that binds to and activates glycine receptors		hp.json	glycine receptor agonists	http://purl.obolibrary.org/obo/CHEBI_64589		3_STAR
HP:0010195	biolink:PhenotypicFeature	Broad middle phalanges of the toes		UMLS:C4023975	hp.json	Broad middle bones of the toes	http://purl.obolibrary.org/obo/HP_0010195		
HP:0010194	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanges of the toes		UMLS:C4023976	hp.json	Absent/underdeveloped middle bones of toe|Absent/small middle bones of toe	http://purl.obolibrary.org/obo/HP_0010194		
CHEBI:76579	biolink:ChemicalSubstance	triradylglycerol	A glycerol compound having one of three possible substituent groups - either acyl, alkyl, or alk-1-enyl - at each of the three possible positions sn-1, sn-2 or sn-3. has functional parent glycerol (CHEBI:17754), children: triglyceride (CHEBI:17855). Parent: is_a glycerolipid (CHEBI:35741)	LIPID_MAPS_class:LMGL0301	hp.json	triradylglycerols	http://purl.obolibrary.org/obo/CHEBI_76579		2_STAR
HP:0010193	biolink:PhenotypicFeature	Duplication of distal phalanx of toe	A partial or complete duplication of one or more distal phalanx of toe.	UMLS:C4021322	hp.json	Duplication of outermost bone of toe|Partial/complete duplication of the distal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010193		
HP:0010192	biolink:PhenotypicFeature	Triangular shaped distal phalanges of the toes		UMLS:C4023977	hp.json	Triangular shaped outermost bone of the toes	http://purl.obolibrary.org/obo/HP_0010192		
HP:0010191	biolink:PhenotypicFeature	Symphalangism affecting the distal phalanges of the toes		UMLS:C4023978	hp.json	Fused outermost bones of toes	http://purl.obolibrary.org/obo/HP_0010191		
HP:0010190	biolink:PhenotypicFeature	Patchy sclerosis of distal toe phalanx	Patchy (irregular) increase in bone density of one or more of the distal phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4021323	hp.json	Patchy sclerosis of the distal phalanges of the toes|Uneven increase in bone density in outermost toe bone	http://purl.obolibrary.org/obo/HP_0010190		
HP:0034104	biolink:PhenotypicFeature	Anti-neutrophil elastase antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neutrophil elastase.		hp.json		http://purl.obolibrary.org/obo/HP_0034104		
HP:0034103	biolink:PhenotypicFeature	Anti-GM1 antibody positivity	Ganglioside-monosialic acid (GM1) is a type of glycosphingolipid with one sialic acid. GM1 is located on the outer layer of the plasma membrane, and plays a vital role in neurogenesis, nerve development, differentiation and repair after injury		hp.json	Anti-ganglioside-monosialic acid antibody positivity	http://purl.obolibrary.org/obo/HP_0034103		
HP:0034106	biolink:PhenotypicFeature	Anti-Su antigen/argonaute 2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Su antigen/argonaute 2.		hp.json	Anti-Su antibody positivity|Anti-Ago2 antibody positivity	http://purl.obolibrary.org/obo/HP_0034106		
HP:0034105	biolink:PhenotypicFeature	Anti-transcription intermediary factor-1gamma antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against transcription intermediary factor-1gamma.		hp.json	Anti-TIF1-gamma antibody positivity|Anti-TIF-1gamma antibody positivity	http://purl.obolibrary.org/obo/HP_0034105		
HP:0034100	biolink:PhenotypicFeature	Anti-phosphatidyl serine antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl serine.		hp.json		http://purl.obolibrary.org/obo/HP_0034100		
HP:0010199	biolink:PhenotypicFeature	Patchy sclerosis of middle toe phalanx	Patchy (irregular) increase in bone density of one or more of the middle phalanges of the toes. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4021319	hp.json	Uneven increase in bone density in middle toe bone|Patchy sclerosis of the middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010199		
HP:0010198	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanges of the toes		UMLS:C4023974	hp.json		http://purl.obolibrary.org/obo/HP_0010198		
HP:0010197	biolink:PhenotypicFeature	Curved middle toe phalanx	A deviation from the normal straight form of one or more middle toe phalanges.	UMLS:C4021320	hp.json	Curved middle bones of the toes|Curved middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010197		
HP:0034102	biolink:PhenotypicFeature	Anti-sphingolipid antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against sphingolipids.		hp.json		http://purl.obolibrary.org/obo/HP_0034102		
HP:0034101	biolink:PhenotypicFeature	Anti-annexin-V antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against annexin-V.		hp.json		http://purl.obolibrary.org/obo/HP_0034101		
HP:0010196	biolink:PhenotypicFeature	Bullet-shaped middle toe phalanx	An abnormal morphology of one or more middle phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021321	hp.json	Bullet-shaped middle bones of the toes|Bullet-shaped middle phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010196		
HP:0034108	biolink:PhenotypicFeature	Anti-Y-box protein-1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Y-box protein-1.		hp.json	Anti-YB 1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034108		
HP:0034107	biolink:PhenotypicFeature	Anti-p53 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against p53.		hp.json		http://purl.obolibrary.org/obo/HP_0034107		
HP:0034109	biolink:PhenotypicFeature	Anti-GW182 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against GW182.		hp.json		http://purl.obolibrary.org/obo/HP_0034109		
HP:0010184	biolink:PhenotypicFeature	Abnormality of toe proximal phalanx	A morphological anomaly of one or more proximal phalanges of one or more toes.	UMLS:C4021327	hp.json	Abnormal innermost toe bone|Abnormality of the proximal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010184		
HP:0009195	biolink:PhenotypicFeature	Epiphyseal stippling of the metacarpals	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the metacarpals.	UMLS:C4021514	hp.json	Stippling of the epiphyses of the metacarpals|Speckled calcifications in end part of the long bone of hand	http://purl.obolibrary.org/obo/HP_0009195		
HP:0009194	biolink:PhenotypicFeature	Small epiphyses of the metacarpals	Abnormally small size of the epiphyses located at the distal end of the metacarpals in respect to age-dependent norms.	UMLS:C4024543	hp.json	Small end part of the long bone of hand	http://purl.obolibrary.org/obo/HP_0009194		
HP:0010183	biolink:PhenotypicFeature	Abnormality of the middle phalanges of the toes		UMLS:C4023981	hp.json	Abnormal middle bones of toe	http://purl.obolibrary.org/obo/HP_0010183		
HP:0010182	biolink:PhenotypicFeature	Abnormality of the distal phalanges of the toes		UMLS:C4023982	hp.json	Abnormality of the outermost bone of the toes	http://purl.obolibrary.org/obo/HP_0010182		
HP:0009197	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the 5th finger	An abnormality of the proximal phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024542	hp.json	Bracket shaped end part of the innermost bone of the pinkie finger|Bracket shaped end part of the innermost bone of the pinky finger|Bracket shaped end part of the innermost bone of the little finger	http://purl.obolibrary.org/obo/HP_0009197		
GO:1904819	biolink:BiologicalProcess	parietal peritoneum development	The process whose specific outcome is the progression of a parietal peritoneum over time, from its formation to the mature structure.		hp.json	peritoneal cavity lining development	http://purl.obolibrary.org/obo/GO_1904819		
HP:0009196	biolink:PhenotypicFeature	Absent metacarpal epiphyses	Absence of the epiphyses of the metacarpal bones, which are normally located at the distal ends of the metacarpals.	UMLS:C4021513	hp.json	Absent metacarpal ossification center|Absent end part of the long bone of hand|Absent metacarpal ossification centre	http://purl.obolibrary.org/obo/HP_0009196		
HP:0010181	biolink:PhenotypicFeature	Duplication of phalanx of toe	Partial/complete duplication of one or more phalanx of toe.	UMLS:C4021328	hp.json	Duplicated toe bone|Partial/complete duplication of the phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010181		
GO:1904818	biolink:BiologicalProcess	visceral peritoneum development	The process whose specific outcome is the progression of a visceral peritoneum over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_1904818		
HP:0009191	biolink:PhenotypicFeature	Ivory epiphyses of the metacarpals	Sclerosis of the epiphyses of the metacarpals, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024545	hp.json	Increased bone density of end part of the long bone of hands	http://purl.obolibrary.org/obo/HP_0009191		
HP:0010180	biolink:PhenotypicFeature	Triangular shaped phalanges of the toes		UMLS:C4023983	hp.json	Triangular shaped toe bones	http://purl.obolibrary.org/obo/HP_0010180		
GO:1904817	biolink:BiologicalProcess	serous membrane development	The process whose specific outcome is the progression of a serous membrane over time, from its formation to the mature structure.		hp.json	serosa development|wall of serous sac development|tunica serosa development	http://purl.obolibrary.org/obo/GO_1904817		
HP:0009190	biolink:PhenotypicFeature	Irregular epiphyses of the metacarpals	Irregular radiographic opacity of the epiphyses of the metacarpals.	UMLS:C4024546	hp.json	Irregular end part of the long bone of hand	http://purl.obolibrary.org/obo/HP_0009190		
HP:0009193	biolink:PhenotypicFeature	Pseudoepiphyses of the metacarpals	A pseudoepiphysis is a secondary ossification center distinct from the normal epiphysis. The normal metacarpal epiphyses are located at the distal ends of the metacarpal bones. Accessory epiphyses (which are also known as pseudoepiphyses) can also occasionally be observed at the proximal ends of the metacarpals, usually involving the 2nd metacarpal bone.	UMLS:C1860253	hp.json	Accessory proximal metacarpal ossification centres|Metacarpal pseudoepiphyses|Accessory proximal metacarpal ossification centers	http://purl.obolibrary.org/obo/HP_0009193		
HP:0009192	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the proximal phalanx of the 5th finger	Absence or underdevelopment (hypoplasia) of the proximal phalanx of the little (5th) finger.	UMLS:C4024544	hp.json	Absent/small innermost pinky finger bone|Absent/small innermost little finger bone|Absent/small innermost pinkie finger bone|Absent/underdeveloped innermost pinky finger bone	http://purl.obolibrary.org/obo/HP_0009192		
HP:0034115	biolink:PhenotypicFeature	Anti-Kelch like protein 12 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Kelch like protein 12.		hp.json	Anti-KLHL-12 antibody positivity	http://purl.obolibrary.org/obo/HP_0034115		
HP:0034114	biolink:PhenotypicFeature	Anti-hexokinase-1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against hexokinase-1.		hp.json	Anti-HK-1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034114		
HP:0034117	biolink:PhenotypicFeature	Anti-angiotensin-converting enzyme 2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against angiotensin-converting enzyme 2.		hp.json	Anti-ACE2 antibody positivity	http://purl.obolibrary.org/obo/HP_0034117		
HP:0010189	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanges of the toes		UMLS:C4023979	hp.json		http://purl.obolibrary.org/obo/HP_0010189		
HP:0034116	biolink:PhenotypicFeature	Anti-thyrotropin receptor antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against thyrotropin receptor antibody.		hp.json		http://purl.obolibrary.org/obo/HP_0034116		
HP:0010188	biolink:PhenotypicFeature	Curved distal toe phalanx	A deviation from the normal straight form of one or more distal toe phalanges.	UMLS:C4021324	hp.json	Curved distal phalanges of the toes|Curved outermost bone of the toe	http://purl.obolibrary.org/obo/HP_0010188		
HP:0034111	biolink:PhenotypicFeature	Anti-MIT3 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against MIT3.		hp.json		http://purl.obolibrary.org/obo/HP_0034111		
HP:0010187	biolink:PhenotypicFeature	Bullet-shaped distal toe phalanx	An abnormal morphology of one or more distal phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021325	hp.json	Bullet-shaped outermost bone of the toe|Bullet-shaped distal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010187		
HP:0034110	biolink:PhenotypicFeature	Anti-Gerbich phenotype 1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ge-1.		hp.json	Anti-Ge-1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034110		
HP:0010186	biolink:PhenotypicFeature	Broad distal phalanx of the toes	Increased width of the distal phalanx of toe of one or more toes.	UMLS:C4023980	hp.json	Wide outermost bone of the toe|Broad outermost bone of the toe	http://purl.obolibrary.org/obo/HP_0010186		
HP:0034113	biolink:PhenotypicFeature	obsolete Anti-type I liver-kidney microsomal antibody positivity	The presence of type I liver-kidney microsomal autoantibodies (immunoglobulins) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034113		
HP:0010185	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanges of the toes	Absence or underdevelopment of the distal phalanges of the toes.	UMLS:C4020773|UMLS:C4021326	hp.json	Absent/underdeveloped outermost bones of toe|Hypoplasia/agenesis of distal phalanges of toes|Absent/small outermost bones of toe|Absent/hypoplastic terminal phalanges of toes	http://purl.obolibrary.org/obo/HP_0010185		
HP:0034112	biolink:PhenotypicFeature	Anti-GM1 IgG antibody positivity	The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against GM1.		hp.json		http://purl.obolibrary.org/obo/HP_0034112		
HP:0034119	biolink:PhenotypicFeature	Anti-GD1a IgG antibody positivity	The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a.		hp.json		http://purl.obolibrary.org/obo/HP_0034119		
HP:0034118	biolink:PhenotypicFeature	Anti-GM1 IgM antibody positivity	The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against GM1.		hp.json		http://purl.obolibrary.org/obo/HP_0034118		
HP:0009188	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the 5th finger	A secondary ossification center in the distal phalanx of the fifth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024548	hp.json		http://purl.obolibrary.org/obo/HP_0009188		
HP:0009187	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the 5th finger	An abnormality of the distal phalanx of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024549	hp.json	Bracket shaped end part of the outermost little finger bone|Bracket shaped end part of the outermost pinky finger bone|Bracket shaped end part of the outermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009187		
CL:0000381	biolink:Cell	neurosecretory neuron		FBbt:00005130	hp.json		http://purl.obolibrary.org/obo/CL_0000381		
CHEBI:132142	biolink:ChemicalSubstance	1,4-naphthoquinones	A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring.		hp.json		http://purl.obolibrary.org/obo/CHEBI_132142		3_STAR
HP:0009189	biolink:PhenotypicFeature	Fragmentation of the metacarpal epiphyses	Fragmented appearance of the epiphyses of the metacarpals.	UMLS:C4024547	hp.json	Fragmentation of end part of the long bone of hand	http://purl.obolibrary.org/obo/HP_0009189		
HP:0010173	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the toes		UMLS:C4023987	hp.json	Absent/small toe bones|Absent/underdeveloped toe bones	http://purl.obolibrary.org/obo/HP_0010173		
HP:0010172	biolink:PhenotypicFeature	Triangular epiphyses of the toes		UMLS:C4023988	hp.json	Triangular end part of the toe bones	http://purl.obolibrary.org/obo/HP_0010172		
HP:0010171	biolink:PhenotypicFeature	Epiphyseal stippling of toe phalanges	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of phalanges of the toes.	UMLS:C4021332	hp.json	Speckled calcifications in long toe bones|Stippling of the epiphyses of the toes	http://purl.obolibrary.org/obo/HP_0010171		
HP:0034120	biolink:PhenotypicFeature	Anti-GD1a IgM antibody positivity	The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a.		hp.json		http://purl.obolibrary.org/obo/HP_0034120		
HP:0010170	biolink:PhenotypicFeature	Small epiphyses of the toes		UMLS:C4023989	hp.json	Small end part of the toe bones	http://purl.obolibrary.org/obo/HP_0010170		
GO:1904829	biolink:BiologicalProcess	regulation of aortic smooth muscle cell differentiation	Any process that modulates the frequency, rate or extent of aortic smooth muscle cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_1904829		
HP:0034126	biolink:PhenotypicFeature	Anti-GD1b IgG antibody positivity	The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside.		hp.json		http://purl.obolibrary.org/obo/HP_0034126		
HP:0034125	biolink:PhenotypicFeature	Anti-GD1b IgM antibody positivity	The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside.		hp.json		http://purl.obolibrary.org/obo/HP_0034125		
HP:0010179	biolink:PhenotypicFeature	Symphalangism affecting the phalanges of the toes		UMLS:C4023984	hp.json	Fused toe bones	http://purl.obolibrary.org/obo/HP_0010179		
HP:0034128	biolink:PhenotypicFeature	Anti-GT1a antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside.		hp.json		http://purl.obolibrary.org/obo/HP_0034128		
HP:0010178	biolink:PhenotypicFeature	Patchy sclerosis of toe phalanx	Uneven (irregular) increase in bone density of one or more of the phalanges of the foot.	UMLS:C4021329	hp.json	Patchy sclerosis of the phalanges of the toes|Uneven increase in bone density in toe bone	http://purl.obolibrary.org/obo/HP_0010178		
HP:0034127	biolink:PhenotypicFeature	Anti-GQ1b IgG antibody positivity	The presence of IgG autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b.		hp.json		http://purl.obolibrary.org/obo/HP_0034127		
GO:1904820	biolink:BiologicalProcess	peritoneum development	The process whose specific outcome is the progression of a peritoneum over time, from its formation to the mature structure.		hp.json	peritonaeum development	http://purl.obolibrary.org/obo/GO_1904820		
HP:0010177	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the toes		UMLS:C4023985	hp.json		http://purl.obolibrary.org/obo/HP_0010177		
HP:0034122	biolink:PhenotypicFeature	Anti-GQ1b antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b.		hp.json		http://purl.obolibrary.org/obo/HP_0034122		
HP:0034121	biolink:PhenotypicFeature	Anti-GD1a antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside D1a.		hp.json		http://purl.obolibrary.org/obo/HP_0034121		
HP:0010176	biolink:PhenotypicFeature	Curved toe phalanx	A deviation from the normal straight form of one or more toe phalanges.	UMLS:C4021330	hp.json	Curved toe bone|Curved phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010176		
HP:0010175	biolink:PhenotypicFeature	Bullet-shaped toe phalanx	An abnormal morphology of one or more phalanges of the toes, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021331	hp.json	Bullet-shaped toe bone|Bullet-shaped phalanges of the toes	http://purl.obolibrary.org/obo/HP_0010175		
HP:0034124	biolink:PhenotypicFeature	Anti-GD1b antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against GD1b ganglioside.		hp.json		http://purl.obolibrary.org/obo/HP_0034124		
HP:0034123	biolink:PhenotypicFeature	Anti-GQ1b IgM antibody positivity	The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against ganglioside Q1b.		hp.json		http://purl.obolibrary.org/obo/HP_0034123		
HP:0010174	biolink:PhenotypicFeature	Broad phalanx of the toes	Increased width of phalanx of one or more toes.	UMLS:C4023986	hp.json	Wide toe bones	http://purl.obolibrary.org/obo/HP_0010174		
CL:0000397	biolink:Cell	ganglion interneuron			hp.json		http://purl.obolibrary.org/obo/CL_0000397		
HP:0034129	biolink:PhenotypicFeature	Anti-GT1a IgM antibody positivity	The presence of IgM autoantibodies (immunoglobulins) in the blood circulation that react against T1a ganglioside.		hp.json		http://purl.obolibrary.org/obo/HP_0034129		
HP:0009199	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the 5th finger	Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 5th finger.	UMLS:C4024541	hp.json	Irregular end part of the innermost pinkie finger bone|Irregular end part of the innermost pinky finger bone|Irregular end part of the innermost little finger bone	http://purl.obolibrary.org/obo/HP_0009199		
HP:0009198	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the 5th finger	Abnormality of the epiphysis of the distal phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx.	UMLS:C4021512	hp.json	Abnormality of end part of the outermost bone of the pinky finger|Abnormality of the epiphysis of the terminal phalanx of the little finger|Abnormality of end part of the outermost bone of the pinkie finger|Abnormality of end part of the outermost bone of the little finger	http://purl.obolibrary.org/obo/HP_0009198		
CHEBI:132153	biolink:ChemicalSubstance	hyaluronate	A carbohydrate acid derivative anion obtained by deprotonation of the carboxy groups of hyaluronic acid; major species at pH 7.3.		hp.json	hyaluronan|hyaluronate polyanion	http://purl.obolibrary.org/obo/CHEBI_132153		3_STAR
CL:0000393	biolink:Cell	electrically responsive cell	A cell whose function is determined by its response to an electric signal.		hp.json		http://purl.obolibrary.org/obo/CL_0000393		
HP:0500030	biolink:PhenotypicFeature	Abnormal hepatic glycogen storage	Change in normal glycogen storage content.		hp.json		http://purl.obolibrary.org/obo/HP_0500030		
GO:1990751	biolink:BiologicalProcess	Schwann cell chemotaxis	The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).		hp.json		http://purl.obolibrary.org/obo/GO_1990751		
HP:0500032	biolink:PhenotypicFeature	Abnormal neuron branching	Abnormality of the structure and branching of the dendrites of a neuron.		hp.json	Aberrant neuronal branching|Abnormal neuronal branching	http://purl.obolibrary.org/obo/HP_0500032		
HP:0500031	biolink:PhenotypicFeature	Sclerosis of the carpal bones	An elevation in bone density in one or more carpal bones of the hand.		hp.json		http://purl.obolibrary.org/obo/HP_0500031		
HP:0500034	biolink:PhenotypicFeature	Nasolacrimal sac obstruction	Blockage of the nasolacrimal sac.		hp.json		http://purl.obolibrary.org/obo/HP_0500034		
HP:0500033	biolink:PhenotypicFeature	Abnormal natural killer subset distribution	Any abnormality in the proportion natural killer subsets relative to the total number of natural killer cells.		hp.json		http://purl.obolibrary.org/obo/HP_0500033		
HP:0500036	biolink:PhenotypicFeature	Nasolacrimal sac papilloma	Benign tumor of the nasolacrimal sac.		hp.json		http://purl.obolibrary.org/obo/HP_0500036		
HP:0500035	biolink:PhenotypicFeature	Nasolacrimal sac granuloma	A mass of granulation tissue in response to chronic dacryocystitis as polypoid formations or they follow accidental injury, from probing and as a reaction to retained foreign bodies in the sac.		hp.json		http://purl.obolibrary.org/obo/HP_0500035		
HP:0010324	biolink:PhenotypicFeature	Abnormal morphology of phalanx of the 2nd toe	An anomaly of a phalanx of second toe.	UMLS:C4023903	hp.json	Abnormality of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010324		
HP:0000998	biolink:PhenotypicFeature	Hypertrichosis	Hypertrichosis is increased hair growth that is abnormal in quantity or location.	UMLS:C0020555|SNOMEDCT_US:29966009|MSH:D006983|SNOMEDCT_US:271607001	hp.json	Excessive hair growth|Increased hair growth on body	http://purl.obolibrary.org/obo/HP_0000998		
HP:0010323	biolink:PhenotypicFeature	Abnormality of the epiphyses of the 2nd toe		UMLS:C4023904	hp.json	Abnormality of the end part of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0010323		
UBERON:0010143	biolink:AnatomicalEntity	seminal vesicle fluid	A bodily secretion that is produced by a seminal vesicle.	NCIT:C33529|UMLS:C0227987|MA:0002526|FMA:62969|BTO:0002053|UMLS:C0036614|NCIT:C52552	hp.json	seminal vesicle secretion|seminal fluid|vesicular fluid|secretion of seminal vesicle	http://purl.obolibrary.org/obo/UBERON_0010143		
HP:0500037	biolink:PhenotypicFeature	Nasolacrimal sac epithelial papillary carcinoma	The malignant epithelial neoplasm with papillary growths in the nasolacrimal sac.		hp.json		http://purl.obolibrary.org/obo/HP_0500037		
HP:0000997	biolink:PhenotypicFeature	Axillary freckling	The presence in the axillary region (armpit) of an increased number of freckles, small circular spots on the skin that are darker than the surrounding skin because of deposits of melanin.	UMLS:C1860335	hp.json		http://purl.obolibrary.org/obo/HP_0000997		hposlim_core
HP:0010322	biolink:PhenotypicFeature	Abnormality of the 5th toe	An anomaly of the little toe.	UMLS:C4023905	hp.json	Abnormality of the little toe|Abnormality of the pinkie toe|Abnormality of the pinky toe	http://purl.obolibrary.org/obo/HP_0010322		
UBERON:0010141	biolink:AnatomicalEntity	primitive sex cord of indifferent gonad	A sex cord that is part of a indifferent gonad.	EHDAA2:0004051	hp.json	primitive sex cords|indifferent sex cord	http://purl.obolibrary.org/obo/UBERON_0010141		
HP:0010321	biolink:PhenotypicFeature	Abnormality of the 4th toe	An anomaly of the fourth toe.	UMLS:C4023906	hp.json	Abnormality of the 4th toe	http://purl.obolibrary.org/obo/HP_0010321		
HP:0500039	biolink:PhenotypicFeature	Conjunctival cicatrization	An abnormality of the conjuctiva and ocular surface caused by conjunctival inflammation and associated with scarring.		hp.json	Cicatricial conjunctivitis|Cicatrizating conjunctivitis|Conjunctival cicatricial conjunctivitis	http://purl.obolibrary.org/obo/HP_0500039		
HP:0000999	biolink:PhenotypicFeature	Pyoderma	Any manifestation of a skin disease associated with the production of pus.	MSH:D011711|SNOMEDCT_US:70759006|UMLS:C0034212	hp.json	Pus-filled lesion	http://purl.obolibrary.org/obo/HP_0000999		
HP:0010320	biolink:PhenotypicFeature	Abnormality of the 3rd toe	An anomaly of the third toe.	UMLS:C4023907	hp.json	Abnormality of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010320		
UBERON:0010147	biolink:AnatomicalEntity	male accessory sex gland	Any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and vesicular glands of the male.	BTO:0004798	hp.json	male accessory reproductive gland|male accessory gland	http://purl.obolibrary.org/obo/UBERON_0010147		pheno_slim
HP:0000992	biolink:PhenotypicFeature	Cutaneous photosensitivity	An increased sensitivity of the skin to light. Photosensitivity may result in a rash upon exposure to the sun (which is known as photodermatosis). Photosensitivity can be diagnosed by phototests in which light is shone on small areas of skin.	MSH:D010787|SNOMEDCT_US:90128006|UMLS:C0349506	hp.json	Sensitivity to sunlight|Photosensitivity|Sun sensitivity|Photosensitive skin|Photosensitive skin rashes|Skin photosensitivity	http://purl.obolibrary.org/obo/HP_0000992		hposlim_core
HP:0010329	biolink:PhenotypicFeature	Abnormality of the epiphyses of the 3rd toe		UMLS:C4023900	hp.json	Abnormality of the end part of the 3rd toe bone	http://purl.obolibrary.org/obo/HP_0010329		
HP:0000991	biolink:PhenotypicFeature	Xanthomatosis	The presence of multiple xanthomas (xanthomata) in the skin. Xanthomas are yellowish, firm, lipid-laden nodules in the skin.	UMLS:C0043325|MSH:D014973|SNOMEDCT_US:63103006	hp.json	Yellow bumps of fatty deposits on skin|Xanthomata	http://purl.obolibrary.org/obo/HP_0000991		
NCBITaxon:50557	biolink:OrganismalEntity	Insecta		GC_ID:1	hp.json	insects|true insects	http://purl.obolibrary.org/obo/NCBITaxon_50557		
HP:0009328	biolink:PhenotypicFeature	Pseudoepiphysis of the middle phalanx of the 3rd finger	A secondary ossification center in the middle phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4021491	hp.json	Pseudoepiphyses of middle phalanx of middle-finger	http://purl.obolibrary.org/obo/HP_0009328		
HP:0010328	biolink:PhenotypicFeature	Polydactyly affecting the 2nd toe		UMLS:C4023901	hp.json		http://purl.obolibrary.org/obo/HP_0010328		
HP:0000993	biolink:PhenotypicFeature	Molluscoid pseudotumors	Bluish-grey, spongy nodules associated with scars over pressure points and easily traumatized areas like the elbows and knees.	UMLS:C1844597	hp.json	Molluscoid pseudotumor	http://purl.obolibrary.org/obo/HP_0000993		
HP:0010327	biolink:PhenotypicFeature	Flexion contracture of the 2nd toe	One or more bent (flexed) joints of the second toe that cannot be straightened actively or passively.	UMLS:C4021296	hp.json	Joint contractures of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010327		
HP:0009327	biolink:PhenotypicFeature	Ivory epiphysis of the middle phalanx of the 3rd finger	Sclerosis of the epiphysis of the middle phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024438	hp.json	Increased bone density of end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009327		
HP:0010326	biolink:PhenotypicFeature	Deviation of the 2nd toe		UMLS:C4021297	hp.json	Displacement of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010326		
HP:0000996	biolink:PhenotypicFeature	Facial capillary hemangioma	Hemangioma, a benign tumor of the vascular endothelial cells with small endothelial spaces, occurring in the face.	UMLS:C1858545	hp.json		http://purl.obolibrary.org/obo/HP_0000996		
HP:0009329	biolink:PhenotypicFeature	Small epiphysis of the middle phalanx of the 3rd finger	Abnormally small size of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger with respect to age-dependent norms.	UMLS:C4024437	hp.json	Small end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009329		
HP:0010325	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 2nd toe		UMLS:C4023902	hp.json	Absent/underdeveloped 2nd toe|Absent/small 2nd toe	http://purl.obolibrary.org/obo/HP_0010325		
HP:0000995	biolink:PhenotypicFeature	Melanocytic nevus	A oval and round, colored (usually medium-to dark brown, reddish brown, or flesh colored) lesion. Typically, a melanocytic nevus is less than 6 mm in diameter, but may be much smaller or larger.	SNOMEDCT_US:21119008|SNOMEDCT_US:400096001|MSH:D009508|UMLS:C0027962|UMLS:C4280269	hp.json	Pigmented naevi|Melanocytic nevi|Nevocellular nevi|Pigmented nevi|Noncancerous mole|Beauty mark|Melanocytic naevus	http://purl.obolibrary.org/obo/HP_0000995		
HP:0009324	biolink:PhenotypicFeature	Enlarged epiphysis of the middle phalanx of the 3rd finger	Abnormally large size of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger with respect to age-dependent norms.	UMLS:C4024441	hp.json	Enlarged end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009324		
HP:0009323	biolink:PhenotypicFeature	Cone-shaped epiphysis of the middle phalanx of the 3rd finger	A cone-shaped appearance of the epiphysis of the middle phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4024442	hp.json	Cone-shaped end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009323		
HP:0009326	biolink:PhenotypicFeature	Irregular epiphysis of the middle phalanx of the 3rd finger	Irregular radiographic opacity of the epiphysis of the middle phalanx of the 3rd finger.	UMLS:C4024439	hp.json	Irregular end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009326		
HP:0009325	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the middle phalanx of the 3rd finger	Fragmented appearance of the epiphysis of the middle phalanx of the 3rd finger.	UMLS:C4024440	hp.json	Fragmentation of end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009325		
HP:0009320	biolink:PhenotypicFeature	Abnormality of the epiphyses of the 3rd finger	Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 3rd finger.	UMLS:C4024445	hp.json	Abnormality of end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009320		
HP:0009322	biolink:PhenotypicFeature	Bracket epiphysis of the middle phalanx of the 3rd finger	An abnormality of the middle phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024443	hp.json	Bracket shaped end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009322		
HP:0009321	biolink:PhenotypicFeature	Absent epiphysis of the middle phalanx of the 3rd finger	Absence of the epiphysis located at the proximal end of the middle phalanx of the 3rd finger.	UMLS:C4024444	hp.json	Absent end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009321		
HP:0500021	biolink:PhenotypicFeature	Reduced brain gamma-aminobutyric acid level by MRS	An decreased level of gamma-aminobutyric acid in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json		http://purl.obolibrary.org/obo/HP_0500021		
HP:0009340	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the 3rd finger	Irregular radiographic opacity of the epiphysis of the distal phalanx of the 3rd finger.	UMLS:C4024427	hp.json	Irregular end part of the outermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009340		
HP:0500020	biolink:PhenotypicFeature	Abnormal cardiac biomarker test	Abnormal blood test results measuring creatine kinase (CK), CK-MB, troponin (TROPI), myoglobin, and/or cardiac enzymes.		hp.json		http://purl.obolibrary.org/obo/HP_0500020		
HP:0500023	biolink:PhenotypicFeature	Shoulder muscle aplasia	Absence of shoulder muscles.		hp.json	Absent shoulder muscle	http://purl.obolibrary.org/obo/HP_0500023		
HP:0500022	biolink:PhenotypicFeature	Abnormal circulating dehydroepiandrosterone concentration	A deviation from the normal concentration of dehydroepiandrosterone in the circulation.		hp.json	Abnormal serum DHEA|Abnormal serum dehydroepiandrosterone level|Abnormal serum androstenolone level	http://purl.obolibrary.org/obo/HP_0500022		
HP:0500024	biolink:PhenotypicFeature	Aplasia of the musculature of the pelvis	Absence of the musculature of the pelvis.		hp.json		http://purl.obolibrary.org/obo/HP_0500024		
UBERON:0009141	biolink:AnatomicalEntity	craniocervical region vein	A vein that is part of a craniocervical region.	SCTID:32945007|EHDAA2:0004542	hp.json	vein of head and neck|craniocervical vein|head and neck veins	http://purl.obolibrary.org/obo/UBERON_0009141		
HP:0500027	biolink:PhenotypicFeature	Aplastic colon	Congenital absence of the colon		hp.json	Aplasia of the colon|Absence of the colon	http://purl.obolibrary.org/obo/HP_0500027		
HP:0034302	biolink:PhenotypicFeature	Megalopapilla	A congenitally anomalous enlarged optic disk (surface area greater than 2.50 square millimeters). It is considered to be a normal variant without physiological defects.		hp.json		http://purl.obolibrary.org/obo/HP_0034302		
HP:0010313	biolink:PhenotypicFeature	Breast hypertrophy	The presence of hypertrophy of the breast.	SNOMEDCT_US:372283008|SNOMEDCT_US:372281005|UMLS:C0392533|UMLS:C0020565|UMLS:C2225524|SNOMEDCT_US:372285001|MSH:C536821	hp.json	Large breast|Hypertrophy of the breasts|Gigantomastia|Macromastia|Breast enlargement|Breasts enlarged	http://purl.obolibrary.org/obo/HP_0010313		hposlim_core
UBERON:0010131	biolink:AnatomicalEntity	conducting tissue of heart	Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers.	FMA:83378|EHDAA2:0004528	hp.json	specialized muscle tissue of heart|specialized conducting tissue of heart	http://purl.obolibrary.org/obo/UBERON_0010131		
HP:0034301	biolink:PhenotypicFeature	Congenital pouch colon	A malformation of the colon in which a pouch-like dilatation of a varying degree of shortened colon is associated with an anorectal malformation. The pouch usually terminates in a fistulous communication with the genitourinary tract.		hp.json		http://purl.obolibrary.org/obo/HP_0034301		
HP:0010312	biolink:PhenotypicFeature	Asymmetry of the breasts	The presence of asymmetrical breasts.	UMLS:C1854013|MSH:C565299	hp.json		http://purl.obolibrary.org/obo/HP_0010312		hposlim_core
HP:0500026	biolink:PhenotypicFeature	Hypoplasia of the musculature of the pelvis	Underdevelopment of the musculature of the pelvis.		hp.json		http://purl.obolibrary.org/obo/HP_0500026		
HP:0010311	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the breasts	Absence or underdevelopment of the breasts.	UMLS:C4023911	hp.json	Absent/small breasts|Absent/underdeveloped breasts	http://purl.obolibrary.org/obo/HP_0010311		
HP:0034304	biolink:PhenotypicFeature	Epsilon wave	An electric signal of depolarization observed between the end of the QRS complex and the beginning of the T wave.		hp.json		http://purl.obolibrary.org/obo/HP_0034304		
HP:0010310	biolink:PhenotypicFeature	Chylothorax	Accumulation of excessive amounts of lymphatic fluid (chyle) in the pleural cavity.	UMLS:C0008733|SNOMEDCT_US:83035003|MSH:D002916	hp.json		http://purl.obolibrary.org/obo/HP_0010310		
UBERON:0010130	biolink:AnatomicalEntity	embryonic autopod plate	The distal elements of the developing limb of vertebrates that will give rise to the autopod (e.g. manus, pes, paw).		hp.json	autopod plate|limb plate	http://purl.obolibrary.org/obo/UBERON_0010130		
HP:0500028	biolink:PhenotypicFeature	Cotton wool plaques	Deposition of large, diffuse cotton wool amyloid plaques (CWPs) lacking a dense core and associated neuritic changes.		hp.json	CWPs	http://purl.obolibrary.org/obo/HP_0500028		
HP:0034303	biolink:PhenotypicFeature	Notched T wave	A bifid T-wave with a notch duration between the 2 peaks at leasy 0.04 sec and an amplitude at least 0.05 mV.		hp.json	Notched T-wave	http://purl.obolibrary.org/obo/HP_0034303		
UBERON:0010135	biolink:AnatomicalEntity	sensory circumventricular organ	A circumventricular organ that is capable of monitoring the levels of substances to the cerebrospinal fluid.	EMAPA:37741|MA:0002944	hp.json	humerosensory system organ|sensory circumventricular organs|sensitive organs|sensitive circumventricular organs|humerosensory circumventricular organ|sensory CVOs|humerosensory system	http://purl.obolibrary.org/obo/UBERON_0010135		pheno_slim
UBERON:0010136	biolink:AnatomicalEntity	epithelial sheet	An epithelial sheet is a flat surface consisting of closely packed epithelial cells.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010136		
HP:0034300	biolink:PhenotypicFeature	Decreased acid sphingomyelinase activity	Reduced enzyme of acid sphingomyelinase activity in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034300		
UBERON:0010133	biolink:AnatomicalEntity	neuroendocrine gland	Any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli.	MA:0000720	hp.json	neuroendocrine system gland	http://purl.obolibrary.org/obo/UBERON_0010133		pheno_slim
UBERON:0010134	biolink:AnatomicalEntity	secretory circumventricular organ	A circumventricular organ that is capable of secreting substances into the cerebrospinal fluid.	EMAPA:35759|MA:0002943	hp.json		http://purl.obolibrary.org/obo/UBERON_0010134		pheno_slim
HP:0034309	biolink:PhenotypicFeature	Multiflagellar spermatozoa	Spermatozoa with multiple flagella attached to the sperm head.		hp.json	Multi-tailed spermatozoa	http://purl.obolibrary.org/obo/HP_0034309		
UBERON:0010129	biolink:AnatomicalEntity	femur cartilage element	A femur endochondral element that is composed primarily of cartilage tissue.	EMAPA:17742	hp.json	femoral cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010129		
HP:0010319	biolink:PhenotypicFeature	Abnormality of the 2nd toe	An anomaly of the second toe.	UMLS:C4023908	hp.json		http://purl.obolibrary.org/obo/HP_0010319		
HP:0010318	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the abdominal wall musculature	Absence or underdevelopment of the abdominal musculature.	UMLS:C4023909	hp.json	Absent/underdeveloped abdominal wall muscles|Absent/small abdominal wall muscles	http://purl.obolibrary.org/obo/HP_0010318		
HP:0010317	biolink:PhenotypicFeature	Scapular aplasia	Absence of the scapulae.	UMLS:C4021298	hp.json	Absent shoulder blade|Absent scapula	http://purl.obolibrary.org/obo/HP_0010317		hposlim_core
HP:0034306	biolink:PhenotypicFeature	Ventricular bigeminy	An electrocardiographic finding of a normal QRS followed by a premature ventricular contraction; a rhythmic pairing of normal and atypical beats originating in the ventricles in a 1-1 ratio such that an ectopic ventricular beat follows each regular heartbeat.		hp.json		http://purl.obolibrary.org/obo/HP_0034306		
HP:0009339	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the 3rd finger	Fragmented appearance of the epiphysis of the distal phalanx of the 3rd finger.	UMLS:C4024428	hp.json	Fragmentation of end part of the outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009339		
HP:0010316	biolink:PhenotypicFeature	Ebstein anomaly of the tricuspid valve	Ebstein's anomaly refers to an abnormally placed and deformed tricuspid valve characterized by apical displacement of the septal and posterior tricuspid valve leaflets, leading to atrialization of the right ventricle with a variable degree of malformation and displacement of the anterior leaflet.	EPCC:06.01.34|UMLS:C0013481|SNOMEDCT_US:204357006|ICD-10:Q22.5|MSH:D004437	hp.json	Ebstein's anomaly|Ebstein's anomaly of the tricuspid valve|Ebstein's malformation	http://purl.obolibrary.org/obo/HP_0010316		
HP:0034305	biolink:PhenotypicFeature	2:1 atrioventricular block	A type of second-degree atrioventricular block in which every other P wave is not conducted through the AV node such that only every other P wave is followed by a QRS complex.		hp.json	2:1 AV block	http://purl.obolibrary.org/obo/HP_0034305		
HP:0009338	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the 3rd finger	Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger with respect to age-dependent norms.	UMLS:C4024429	hp.json	Enlarged end part of the outermost bone of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009338		
HP:0010315	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the diaphragm	Absence or underdevelopment of the diaphragm.	UMLS:C4023910	hp.json	Absent/small diaprhagm|Absent/underdeveloped diaprhagm	http://purl.obolibrary.org/obo/HP_0010315		
HP:0034308	biolink:PhenotypicFeature	Prolonged P wave	Abnormal increased in the duration of the P wave, which is a marker of delayed inter-atrial conduction.		hp.json		http://purl.obolibrary.org/obo/HP_0034308		
HP:0034307	biolink:PhenotypicFeature	Elevated left ventricular end-diastolic diameter	The LV end-diastolic internal diameter was measured from two-dimensional (2D) images in the parasternal long-axis view, timed with mitral valve closure at the level of the mitral valve chordae.		hp.json		http://purl.obolibrary.org/obo/HP_0034307		
HP:0010314	biolink:PhenotypicFeature	Premature thelarche	Premature development of the breasts.	UMLS:C0425772|SNOMEDCT_US:102889008	hp.json	Premature breast development	http://purl.obolibrary.org/obo/HP_0010314		
HP:0009335	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the 3rd finger	Absence of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger.	UMLS:C4024432	hp.json	Absent end part of the outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009335		
UBERON:0009142	biolink:AnatomicalEntity	entire embryonic mesenchyme	Sum total of mesenchyme in the embryo.	EHDAA2:0001113|EMAPA:16097|EHDAA:177	hp.json		http://purl.obolibrary.org/obo/UBERON_0009142		
HP:0009334	biolink:PhenotypicFeature	Abnormality of the epiphysis of the middle phalanx of the 3rd finger		UMLS:C4024433	hp.json	Abnormality of the middle part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009334		
HP:0009337	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the 3rd finger	A cone-shaped appearance of the epiphysis of the distal phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4024430	hp.json	Cone-shaped end part of the outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009337		
HP:0009336	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the 3rd finger	An abnormality of the distal phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024431	hp.json	Bracket shaped end part of the outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009336		
UBERON:0009145	biolink:AnatomicalEntity	pharyngeal region of foregut		RETIRED_EHDAA2:0001454|EMAPA:16549	hp.json	pharyngeal region	http://purl.obolibrary.org/obo/UBERON_0009145		
GO:1990765	biolink:BiologicalProcess	colon smooth muscle contraction	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum.		hp.json		http://purl.obolibrary.org/obo/GO_1990765		
HP:0009331	biolink:PhenotypicFeature	Triangular epiphysis of the middle phalanx of the 3rd finger	A triangular appearance of the epiphysis of the middle phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4021490	hp.json	Delta-shaped epiphysis of the middle phalanx of the 3rd finger|Triangular end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009331		
HP:0009330	biolink:PhenotypicFeature	Stippling of the epiphysis of the middle phalanx of the 3rd finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 3rd finger.	UMLS:C4024436	hp.json	Speckled calcifications in end part of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009330		
HP:0009333	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the 3rd finger		UMLS:C4024434	hp.json	Abnormality of the end part of the innermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009333		
HP:0009332	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the 3rd finger		UMLS:C4024435	hp.json	Abnormality of the end part of the outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009332		
GO:1990768	biolink:BiologicalProcess	gastric mucosal blood circulation	The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products.		hp.json	stomach mucosal blood circulation	http://purl.obolibrary.org/obo/GO_1990768		
HP:0500010	biolink:PhenotypicFeature	obsolete Increased cholesterol esters			hp.json		http://purl.obolibrary.org/obo/HP_0500010		
HP:0500012	biolink:PhenotypicFeature	Abnormal gonadotropin-releasing hormone concentration	A deviation from the normal circulating concentration of the normal gonadotropin-releasing hormone (GnRH). Intermittent GnRH secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH).		hp.json	Abnormality of GnRH level|Abnormality of gonadotropin-releasing hormone level	http://purl.obolibrary.org/obo/HP_0500012		
HP:0500011	biolink:PhenotypicFeature	Moon facies	A rounded, puffy face with fat deposits in the temporal fossa and cheeks, a double chin.		hp.json	Puffy face|Puffy facies|Moon face	http://purl.obolibrary.org/obo/HP_0500011		
GO:1990770	biolink:BiologicalProcess	small intestine smooth muscle contraction	A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine.		hp.json		http://purl.obolibrary.org/obo/GO_1990770		
HP:0500014	biolink:PhenotypicFeature	obsolete Abnormal test result			hp.json		http://purl.obolibrary.org/obo/HP_0500014		
HP:0500013	biolink:PhenotypicFeature	Lack of gonadotropin-releasing hormone pulsatility	Secretion of gonadotropin-releasing hormone that does not occur in a pulsatile fashion.		hp.json	Absence of GnRH pulsatility	http://purl.obolibrary.org/obo/HP_0500013		
HP:0010302	biolink:PhenotypicFeature	Spinal cord tumor	A neoplasm affecting the spinal cord.	UMLS:C0037930|MSH:D013120|NCIT:C3262|SNOMEDCT_US:126962006	hp.json	Tumour of the spinal cord|Spinal cord tumor|Spinal tumors|Tumor of the spinal cord|Spinal cord tumour|Spinal tumour|Spinal tumor|Spinal tumours	http://purl.obolibrary.org/obo/HP_0010302		
HP:0000976	biolink:PhenotypicFeature	Eczematoid dermatitis		MSH:D004485|UMLS:C0013595|SNOMEDCT_US:281104002|SNOMEDCT_US:43116000	hp.json		http://purl.obolibrary.org/obo/HP_0000976		
HP:0034313	biolink:PhenotypicFeature	Hyperdynamic left ventricular ejection fraction	An abnoramlly increased ejection fraction of the left ventricle, usually defined as a left ventricular ejection fraction greater than 70 percent.		hp.json		http://purl.obolibrary.org/obo/HP_0034313		
HP:0500016	biolink:PhenotypicFeature	Abnormal cardiac MRI	Abnormal results of a MRI for the heart.		hp.json	Abnormal cardiac magnetic resonance imaging|Abnormal heart MRI	http://purl.obolibrary.org/obo/HP_0500016		
HP:0034312	biolink:PhenotypicFeature	Nocturnal hypoxemia	Abnormally reduced oxyhemoglobin saturation during sleep (nocturnal). Different thresholds are used in the literature, including more than 10 percent of total sleep time below a SpO2 of 90 percent.		hp.json	Sleep hypoxemia|Sleep-related hypoxemia	http://purl.obolibrary.org/obo/HP_0034312		
HP:0000975	biolink:PhenotypicFeature	Hyperhidrosis	Abnormal excessive perspiration (sweating) despite the lack of appropriate stimuli like hot and humid weather.	SNOMEDCT_US:364538006|SNOMEDCT_US:415690000|SNOMEDCT_US:415691001|UMLS:C0038990|SNOMEDCT_US:161857006|SNOMEDCT_US:312230002|UMLS:C0020458|MSH:D013546|SNOMEDCT_US:52613005|MSH:D006945|UMLS:C0700590|MEDDRA:10020642	hp.json	Sweating, increased|Profuse sweating|Excessive sweating|Sweating|Increased sweating|Diaphoresis|Sweating profusely	http://purl.obolibrary.org/obo/HP_0000975		hposlim_core
HP:0010301	biolink:PhenotypicFeature	Spinal dysraphism	A heterogeneous group of congenital spinal anomalies that result from defective closure of the neural tube early in fetal life.	UMLS:C0027794|SNOMEDCT_US:253098009|MSH:D009436	hp.json	Incomplete closure of the vertebral arch	http://purl.obolibrary.org/obo/HP_0010301		
HP:0500015	biolink:PhenotypicFeature	Abnormal cardiac test	Abnormal test result of cardiovascular physiology.		hp.json		http://purl.obolibrary.org/obo/HP_0500015		
HP:0010300	biolink:PhenotypicFeature	Abnormally low-pitched voice	An abnormally low-pitched voice.	UMLS:C4023915	hp.json		http://purl.obolibrary.org/obo/HP_0010300		
HP:0000978	biolink:PhenotypicFeature	Bruising susceptibility	An ecchymosis (bruise) refers to the skin discoloration caused by the escape of blood into the tissues from ruptured blood vessels. This term refers to an abnormally increased susceptibility to bruising. The corresponding phenotypic abnormality is generally elicited on medical history as a report of frequent ecchymoses or bruising without adequate trauma.	SNOMEDCT_US:302227002|UMLS:C0423798|SNOMEDCT_US:424131007|SNOMEDCT_US:425075004|UMLS:C0013491|SNOMEDCT_US:77643000|MSH:D004438	hp.json	Bruisability|Easy bruising|Bruise easily|Easy bruisability|Bruising susceptibility	http://purl.obolibrary.org/obo/HP_0000978		
HP:0034315	biolink:PhenotypicFeature	Chronic cough	A persistent cough, defined as a cough lasting longer than eight weeks in adults or longer than four weeks in children.		hp.json		http://purl.obolibrary.org/obo/HP_0034315		
HP:0500018	biolink:PhenotypicFeature	Abnormal cardiac exercise stress test	Abnormal results of exercise on heart function.		hp.json	Abnormal cardiac exercise test|Abnormal exercise test|Abnormal treadmill test	http://purl.obolibrary.org/obo/HP_0500018		
HP:0000977	biolink:PhenotypicFeature	Soft skin	Subjective impression of increased softness upon palpation of the skin.	UMLS:C1844592|UMLS:C0241178	hp.json	Soft skin|Velvety skin texture|Velvety skin	http://purl.obolibrary.org/obo/HP_0000977		hposlim_core
HP:0034314	biolink:PhenotypicFeature	Abnormal left ventricular ejection fraction	Any abnormality of the left ventricular ejection fraction (LVEF), which is the fraction of chamber volume ejected in systole (stroke volume) in relation to the volume of the blood in the ventricle at the end of diastole (end-diastolic volume). Stroke volume (SV) is calculated as the difference between end-diastolic volume (EDV) and end-systolic volume (ESV). LVEF is calculated as [SV/EDV] in percent.		hp.json		http://purl.obolibrary.org/obo/HP_0034314		
HP:0500017	biolink:PhenotypicFeature	Abnormal cardiac catheterization	Abnormal results from the diagnostic tests resulting from cardiac catheterization.		hp.json	Abnormal cardiac cath	http://purl.obolibrary.org/obo/HP_0500017		
HP:0500019	biolink:PhenotypicFeature	Abnormal resting energy expenditure from metabolic cart test	Resting energy expenditure (REE) can be measured with indirect calorimetry using a metabolic cart, which is used to measure the oxygen consumption (VO2) and carbon dioxide production (VCO2).		hp.json	Abnormal metabolic cart test	http://purl.obolibrary.org/obo/HP_0500019		
HP:0000979	biolink:PhenotypicFeature	Purpura	Purpura (from Latin: purpura, meaning "purple") is the appearance of red or purple discolorations on the skin that do not blanch on applying pressure. They are caused by bleeding underneath the skin. This term refers to an abnormally increased susceptibility to developing purpura. Purpura are larger than petechiae.	SNOMEDCT_US:423902002|SNOMEDCT_US:387778001|UMLS:C0034150|SNOMEDCT_US:12393003|MSH:D011693	hp.json	Blood spots|Red or purple spots on the skin	http://purl.obolibrary.org/obo/HP_0000979		hposlim_core
UBERON:0010125	biolink:AnatomicalEntity	future superior salivatory nucleus	A gray matter that has the potential to develop into a superior salivatory nucleus.	EHDAA2:0004644	hp.json		http://purl.obolibrary.org/obo/UBERON_0010125		
HP:0034311	biolink:PhenotypicFeature	Hypoplastic optic chiasm	Developmental defect characterized by undergrowth of the optic chiasm.		hp.json	Optic chiasm hypoplasia	http://purl.obolibrary.org/obo/HP_0034311		
HP:0034310	biolink:PhenotypicFeature	Post-vaccination yellow fever	Infection with the yellow fever virus of the live-attenuated vaccine.		hp.json	Postvaccination yellow fever	http://purl.obolibrary.org/obo/HP_0034310		
UBERON:0010123	biolink:AnatomicalEntity	future facial nucleus	A gray matter that has the potential to develop into a facial nucleus.	EHDAA2:0004639	hp.json		http://purl.obolibrary.org/obo/UBERON_0010123		
UBERON:0009139	biolink:AnatomicalEntity	right posterior cardinal vein	A posterior cardinal vein that is in_the_right_side_of a multicellular organism.	FMA:70315|EHDAA2:0004536	hp.json	posterior cardinal vein right|right postcardinal vein	http://purl.obolibrary.org/obo/UBERON_0009139		
HP:0009309	biolink:PhenotypicFeature	Triangular shaped middle phalanx of the 4th finger	Triangular shaped middle phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024452	hp.json	Triangular shaped middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009309		
HP:0010309	biolink:PhenotypicFeature	Bifid sternum	The sternal cleft is a rare congenital anomaly resulting from a fusion failure of the sternum.	UMLS:C0265696|SNOMEDCT_US:54008006	hp.json	Sternal cleft	http://purl.obolibrary.org/obo/HP_0010309		hposlim_core
HP:0010308	biolink:PhenotypicFeature	Asternia	The congenital absence of the sternum.	UMLS:C4023912	hp.json	Breast bone aplasia|Aplasia of the sternum	http://purl.obolibrary.org/obo/HP_0010308		
HP:0000970	biolink:PhenotypicFeature	Anhidrosis	Inability to sweat.	SNOMEDCT_US:39659002|MSH:D007007|SNOMEDCT_US:14662005|UMLS:C0003028|MEDDRA:10002512	hp.json	Sudomotor dysfunction|Sweating dysfunction|Lack of sweating|Anhydrosis	http://purl.obolibrary.org/obo/HP_0000970		hposlim_core
HP:0010307	biolink:PhenotypicFeature	Stridor	Stridor is a high pitched sound resulting from turbulent air flow in the upper airway.	UMLS:C0237304|SNOMEDCT_US:248573009|SNOMEDCT_US:70407001|UMLS:C0038450|MSH:D012135	hp.json	Noisy breathing	http://purl.obolibrary.org/obo/HP_0010307		
HP:0010306	biolink:PhenotypicFeature	Short thorax	Reduced inferior to superior extent of the thorax.	UMLS:C0426789|SNOMEDCT_US:249670005	hp.json	Shorter than typical length between neck and abdomen	http://purl.obolibrary.org/obo/HP_0010306		
HP:0009306	biolink:PhenotypicFeature	Triangular shaped distal phalanx of the 4th finger	Triangular shaped distal phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024455	hp.json	Triangular shaped outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009306		
HP:0000972	biolink:PhenotypicFeature	Palmoplantar hyperkeratosis	Abnormal thickening of the skin localized to the palm of the hand and the sole of the foot.	SNOMEDCT_US:706885006|MSH:D007645|UMLS:C0022596	hp.json	Palmoplantar keratosis|Thickening of the outer layer of the skin of the palms and soles|Thick palms and soles|Hyperkeratosis of the palms and soles|Hyperkeratosis of palms and soles|Palmoplantar keratoses|Thickened palms and soles	http://purl.obolibrary.org/obo/HP_0000972		hposlim_core
HP:0034317	biolink:PhenotypicFeature	Unusual viral infection			hp.json		http://purl.obolibrary.org/obo/HP_0034317		
HP:0010305	biolink:PhenotypicFeature	Absence of the sacrum	Absence (aplasia) of the sacrum.	MSH:C537221|UMLS:C0344490|SNOMEDCT_US:205425003	hp.json	Absent sacrum|Sacrococcygeal agenesis|Sacral agenesis	http://purl.obolibrary.org/obo/HP_0010305		hposlim_core
HP:0000971	biolink:PhenotypicFeature	Abnormal sweat gland morphology	Any structural abnormality of the sweat gland.	UMLS:C0262643|UMLS:C4020881|MSH:D013543|UMLS:C0038986|SNOMEDCT_US:88232005	hp.json	Abnormalities of sweating|Sweat gland disease|Abnormality of the sweat gland	http://purl.obolibrary.org/obo/HP_0000971		
HP:0009305	biolink:PhenotypicFeature	Distal/middle symphalangism of 4th finger	Fusion of the terminal/distal and middle phalanges of the 4th finger.	UMLS:C4021495	hp.json	Symphalangism of the distal and middle phalanges of the 4th finger|Fused outermost and middle bones of ring finger	http://purl.obolibrary.org/obo/HP_0009305		
HP:0034316	biolink:PhenotypicFeature	Thinning of the substantia nigra pars compacta	Reduced volume of pars compacta of the substantia nigra.		hp.json		http://purl.obolibrary.org/obo/HP_0034316		
HP:0010304	biolink:PhenotypicFeature	Spinal meningeal diverticulum	An outpouching of the spinal meninges.	UMLS:C4023913	hp.json		http://purl.obolibrary.org/obo/HP_0010304		
HP:0000974	biolink:PhenotypicFeature	Hyperextensible skin	A condition in which the skin can be stretched beyond normal, and then returns to its initial position.	UMLS:C0241074	hp.json	Hyperelastic skin|Skin hyperelasticity|Stretchable skin|Skin hyperextensibility	http://purl.obolibrary.org/obo/HP_0000974		hposlim_core
HP:0009308	biolink:PhenotypicFeature	Symphalangism of middle phalanx of 4th finger	Fusion of the middle phalanx of the 4th finger with another bone.	UMLS:C4024453	hp.json	Fused middle bone of ring finger	http://purl.obolibrary.org/obo/HP_0009308		
HP:0034319	biolink:PhenotypicFeature	CNS vasculitis with reactivation of varicella-zoster virus	A vasculopathy in the central nervous system (CNS) following reactivation of varicella-zoster virus due to a productive viral infection of both large and small cerebral arteries.		hp.json		http://purl.obolibrary.org/obo/HP_0034319		
HP:0009307	biolink:PhenotypicFeature	Patchy sclerosis of the middle phalanx of the 4th finger	Uneven (irregular) increase in bone density of the middle phalanx of the fourth finger.	UMLS:C4024454	hp.json	Uneven increase in bone density in the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009307		
HP:0000973	biolink:PhenotypicFeature	Cutis laxa	Wrinkled, redundant, inelastic and sagging skin.	UMLS:C0010495|MSH:D003483|MSH:C531660|UMLS:C4280606|UMLS:C2930812|SNOMEDCT_US:58588007	hp.json	Lax skin|Chalazoderma|Hanging skin|Dermatomegaly|Hypoelastic skin|Inelastic skin|Dermatochalasia|Loose and inelastic skin|Cutaneous laxity|Generalized elastolysis|Loose skin|Skin laxity|Generalised elastolysis|Elastolysis	http://purl.obolibrary.org/obo/HP_0000973		
HP:0010303	biolink:PhenotypicFeature	Abnormal spinal meningeal morphology	Any abnormality of the spinal meninges, the system of membranes (dura mater, the arachnoid mater, and the pia mater) which envelops the spinal cord.	UMLS:C4023914	hp.json	Abnormality of the spinal meninges	http://purl.obolibrary.org/obo/HP_0010303		
HP:0034318	biolink:PhenotypicFeature	Unusual virus reactivation	Reactivation is the mechanism whereby a latent virus that has infected a host cell switches to a lytic stage, undergoing productive viral replication and allowing the virus to spread. This term refers to reactivation regarded as unusual because of frequency, intensity, location, or nature of the virus, in the sense that the rreactivation would not be observed in an immunocompetent host.		hp.json		http://purl.obolibrary.org/obo/HP_0034318		
HP:0009302	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the 4th finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the 4th finger is affected.	UMLS:C4024458	hp.json	Bullet-shaped outermost bone of ring finger	http://purl.obolibrary.org/obo/HP_0009302		
HP:0009301	biolink:PhenotypicFeature	Short proximal phalanx of the 4th finger	Hypoplastic/small proximal phalanx of the fourth finger.	UMLS:C4021496	hp.json	Short proximal phalanx of the fourth finger|Short innermost bone of the ring finger|Hypoplastic/small proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009301		
UBERON:0009132	biolink:AnatomicalEntity	peroneus	One of a group of three muscles fibularis (peronæus) longus, brevis, and tertius originating on the fibula and inserting on the metatarsals.	EHDAA:8297|EMAPA:36251|EHDAA2:0001450	hp.json	fibularis|fibularis muscle|peroneal muscle|peroneal muscle group|peroneus muscle|peronæus muscle|peroneal muscles	http://purl.obolibrary.org/obo/UBERON_0009132		pheno_slim
HP:0009304	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the 4th finger	Uneven (irregular) increase in bone density of the distal phalanx of the fourth finger.	UMLS:C4024456	hp.json	Uneven increase in bone density in the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009304		
UBERON:0009133	biolink:AnatomicalEntity	pleuroperitoneal membrane	A fold of tissue which extends into the peritoneal cavity of the developing embryo and participates in the separation of the pleural and peritoneal cavities.	SCTID:361429005|UMLS:C1283968|EMAPA:17709|VHOG:0000757|NCIT:C34256|EHDAA2:0001483|Wikipedia:Pleuroperitoneal	hp.json	pleuroperitoneal fold|pleuroperitoneal membranes	http://purl.obolibrary.org/obo/UBERON_0009133		
HP:0009303	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanx of the 4th finger	Dissolution or degeneration of bone tissue of the distal phalanx of the 4th finger.	UMLS:C4024457	hp.json		http://purl.obolibrary.org/obo/HP_0009303		
GO:1990777	biolink:CellularComponent	lipoprotein particle	A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph.		hp.json		http://purl.obolibrary.org/obo/GO_1990777		
HP:0009300	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the proximal phalanx of the 4th finger		UMLS:C4020658	hp.json	Absent/small innermost ring finger bone|Absent/underdeveloped innermost ring finger bone	http://purl.obolibrary.org/obo/HP_0009300		
GO:1990778	biolink:BiologicalProcess	protein localization to cell periphery	A process in which a protein is transported to, or maintained in, the cell periphery.		hp.json		http://purl.obolibrary.org/obo/GO_1990778		
HP:0500001	biolink:PhenotypicFeature	Body odor	A perceived unpleasant smell given off by the body.		hp.json	Bromidrosis|Body odor|Body odour|BO|Osmidrosis|Bromhidrosis	http://purl.obolibrary.org/obo/HP_0500001		
HP:0034324	biolink:PhenotypicFeature	Brachiocephalic artery aneurysm	An abnormal widening (dilatation) of the brachiocephalic artery		hp.json	Dilatated brachiocephalic artery|Innominate artery aneurysm	http://purl.obolibrary.org/obo/HP_0034324		
HP:0000987	biolink:PhenotypicFeature	Atypical scarring of skin	Atypically scarred skin .	UMLS:C4021786	hp.json	Atypical scarring|Atypical scarring of skin	http://purl.obolibrary.org/obo/HP_0000987		
HP:0500005	biolink:PhenotypicFeature	Anal pain	Pain in and around the anus or rectum (perianal region).		hp.json	Rectal pain|Anal pain	http://purl.obolibrary.org/obo/HP_0500005		
HP:0034323	biolink:PhenotypicFeature	Reduced circulating growth hormone concentration	Concentration of growth hormone in the blood circulation below normal limits.		hp.json		http://purl.obolibrary.org/obo/HP_0034323		
HP:0500007	biolink:PhenotypicFeature	Iris flocculi	Multiple cysts along the pupillary margin that appear as spherical or tear-drop-shaped pigmented lesions or wrinkled masses emerging from the pupillary border of the iris.		hp.json		http://purl.obolibrary.org/obo/HP_0500007		
HP:0000989	biolink:PhenotypicFeature	Pruritus	Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.	SNOMEDCT_US:424492005|MSH:D011537|SNOMEDCT_US:418363000|SNOMEDCT_US:418290006|SNOMEDCT_US:279333002|UMLS:C0033774	hp.json	Itching|Skin itching|Itchy skin	http://purl.obolibrary.org/obo/HP_0000989		hposlim_core
HP:0034326	biolink:PhenotypicFeature	Adenomyosis	Ectopic endometrial tissue within the uterine myometrium.		hp.json		http://purl.obolibrary.org/obo/HP_0034326		
HP:0034325	biolink:PhenotypicFeature	Common carotid artery aneurysm	An abnormal widening (dilatation) of the common carotid artery.		hp.json		http://purl.obolibrary.org/obo/HP_0034325		
HP:0000988	biolink:PhenotypicFeature	Skin rash	A red eruption of the skin.	MSH:D005076|UMLS:C0015230|MEDDRA:10037844|SNOMEDCT_US:112625008|SNOMEDCT_US:271807003	hp.json	Rash|Skin rash	http://purl.obolibrary.org/obo/HP_0000988		
HP:0500006	biolink:PhenotypicFeature	Urethritis	Inflammation of the urethra.		hp.json		http://purl.obolibrary.org/obo/HP_0500006		
HP:0034320	biolink:PhenotypicFeature	Muscle fiber intracytoplasmic reducing inclusion bodies	Intracytoplasmic inclusions in myofibers that reduce nitro-blue tetrazolium (NBT) and thus stain strongly with the menadione-NBT stain.		hp.json	Intracytoplasmic myofiber reducing inclusion bodies	http://purl.obolibrary.org/obo/HP_0034320		
HP:0500009	biolink:PhenotypicFeature	Dysplastic gangliocytoma of the cerebellum	It is a rare, slowly growing tumor of the cerebellum, a gangliocytoma sometimes considered to be a hamartoma, characterized by diffuse hypertrophy of the granular layer of the cerebellum.		hp.json	Lhermitte-Duclos disease|LDD	http://purl.obolibrary.org/obo/HP_0500009		
HP:0500008	biolink:PhenotypicFeature	Cornea verticillata	Golden brown or gray deposits with a clockwise, whorl-like distribution in the inferior interpalpebal portion of the cornea.		hp.json	Vortex keratopathy	http://purl.obolibrary.org/obo/HP_0500008		
HP:0034322	biolink:PhenotypicFeature	Reduced galactocerebrosidase activity	Diminished enzyme activity of galactocerebrosidase.		hp.json		http://purl.obolibrary.org/obo/HP_0034322		
HP:0034321	biolink:PhenotypicFeature	Elevated circulating guanidinoacetic acid concentration	An increased concentration of guanidinoacetic acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034321		
UBERON:0009129	biolink:AnatomicalEntity	right atrium endocardium	Endocardium that is part of the right atrium.	VHOG:0001228|EHDAA2:0000274|FMA:7281|SCTID:3194006|NCIT:C102339	hp.json	endocardium of right atrium|right atrium endocardial tissue|right atrial endocardium	http://purl.obolibrary.org/obo/UBERON_0009129		
HP:0000980	biolink:PhenotypicFeature	Pallor	Abnormally pale skin.	SNOMEDCT_US:398979000|MSH:D010167|UMLS:C0030232	hp.json	Paleness|Skin paleness	http://purl.obolibrary.org/obo/HP_0000980		
HP:0009317	biolink:PhenotypicFeature	Deviation of the 3rd finger	Displacement of the 3rd finger from its normal position.	UMLS:C4021493	hp.json	Deviated middle finger	http://purl.obolibrary.org/obo/HP_0009317		
HP:4000092	biolink:PhenotypicFeature	Poor conversational reciprocity	Reduced ability to conduct a reciprocal (back and forth) conversation characterized by deficits in the ability to make comments about discussion topics of others, failure to ask questions, and not building a conversation on comments of others. Affected persons may not know what to say next in a conversation, may not notice if others are bored with a given topic, may conduct a one-sided conversation (talking but not listening), or may veer off topic more than is socially acceptable.		hp.json	Failure of normal back-and-forth conversation	http://purl.obolibrary.org/obo/HP_4000092		
HP:0034328	biolink:PhenotypicFeature	Fibro-obliterative bile-duct lesion	A condition in which the lumen of a bile duct has been filled by fibrous scar material, in effect replacing the bile duct with a fibrous scar.		hp.json	Fibro-obliterative bile-duct scarring|Fibro-obliterative loss of bile ducts	http://purl.obolibrary.org/obo/HP_0034328		
HP:0009316	biolink:PhenotypicFeature	Abnormal 3rd finger phalanx morphology	Abnormality of the phalanges of the 3rd (middle) finger.	UMLS:C4021494	hp.json	Abnormality of the middle finger bones|Abnormality of middle finger phalanges|Abnormality of 3rd finger phalanges|Abnormality of the phalanges of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009316		
HP:0000982	biolink:PhenotypicFeature	Palmoplantar keratoderma	Abnormal thickening of the skin of the palms of the hands and the soles of the feet.	MSH:D007645|UMLS:C0022596|SNOMEDCT_US:706885006	hp.json	Thickening of palms and soles|Palmar and plantar keratoderma	http://purl.obolibrary.org/obo/HP_0000982		
HP:0034327	biolink:PhenotypicFeature	Posterior corneal stroma punctiform multicolored opacities	Thin, punctiform elements of various colors in the posterior stroma of the cornea, immediately anterior to Descemet membrane. The elements are visible to direct and indirect illumination.		hp.json	Punctiform multicolored opacities in the posterior corneal stroma	http://purl.obolibrary.org/obo/HP_0034327		
HP:0009319	biolink:PhenotypicFeature	Joint contracture of the 3rd finger	Chronic loss of joint motion in the 3rd finger due to structural changes in non-bony tissue. The term camptodactyly of the 3rd finger is used if the distal and/or proximal interphalangeal joints are affected.	UMLS:C4021492	hp.json	Camptodactyly of middle finger	http://purl.obolibrary.org/obo/HP_0009319		
HP:4000090	biolink:PhenotypicFeature	Abnormal communicative gestures			hp.json	Abnormal gestures	http://purl.obolibrary.org/obo/HP_4000090		
HP:0009318	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 3rd finger	A small/hypoplastic or absent/aplastic 3rd (middle) finger.	UMLS:C4024446	hp.json	Absent/small middle finger|Absent/underdeveloped middle finger	http://purl.obolibrary.org/obo/HP_0009318		
HP:0034329	biolink:PhenotypicFeature	Dysplastic megalencephaly	A congenital brain malformation characterized by marked overgrowth and dysplasia affecting one or both cerebral hemispheres, and, in some cases, subcortical brain regions as well. The presence of dysplasia in dysplastic megalencephaly distinguishes it from other forms of generalized megalencephaly.		hp.json	Bilateral hemimegalencephaly	http://purl.obolibrary.org/obo/HP_0034329		
HP:0009313	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the 4th finger	Uneven (irregular) increase in bone density of the proximal phalanx of the fourth finger.	UMLS:C4024449	hp.json	Uneven increase in bone density in the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009313		
HP:0009312	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanx of the 4th finger	Dissolution or degeneration of bone tissue of the proximal phalanx of the 4th finger.	UMLS:C4024450	hp.json		http://purl.obolibrary.org/obo/HP_0009312		
UBERON:0009122	biolink:AnatomicalEntity	adenohypophyseal placode	The adenohypophyseal placode forms the anterior lobe of the pituitary gland and gives rise to the endocrine secretory cells of the pituitary.	XAO:0004208|EFO:0000229|ZFA:0001198|TAO:0001198	hp.json	pituitary placode	http://purl.obolibrary.org/obo/UBERON_0009122		efo_slim
HP:0009315	biolink:PhenotypicFeature	Triangular shaped proximal phalanx of the 4th finger	Triangular shaped proximal phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024447	hp.json	Triangular shaped innermost bone of the 4th finger|Triangular shaped innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009315		
HP:0009314	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanx of the 4th finger	Fusion of the proximal phalanx of the 4th finger with another bone.	UMLS:C4024448	hp.json	Fused innermost bone of ring finger	http://purl.obolibrary.org/obo/HP_0009314		
UBERON:0009124	biolink:AnatomicalEntity	geniculate placode	Rostralmost epibranchial placode. Associated with 1st branchial cleft.	TAO:0001295|EHDAA2:0004206|XAO:0004211|ZFA:0001295	hp.json	facial placode|hyoid VII placode|facial epibranchial placode|facial VII placode|epibranchial placode 1|hyoid placode	http://purl.obolibrary.org/obo/UBERON_0009124		
UBERON:0009125	biolink:AnatomicalEntity	petrosal placode	Epibranchial placode between geniculate and nodose. Associated with 2nd branchial cleft.	TAO:0001296|EHDAA2:0004207|XAO:0004212|ZFA:0001296	hp.json	glossopharyngeal epibranchial placode|epibranchial placode 2|glossopharyngeal placode|glossopharyngeal IX placode	http://purl.obolibrary.org/obo/UBERON_0009125		
HP:0009311	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the 4th finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the 4th finger is affected.	UMLS:C4024451	hp.json	Bullet-shaped innermost ring finger bone	http://purl.obolibrary.org/obo/HP_0009311		
UBERON:0009126	biolink:AnatomicalEntity	nodosal placode	Caudalmost epibranchial placode. Associated with 3rd branchial cleft.	EHDAA2:0004208|XAO:0004213	hp.json	nodose placode|vagal epibranchial placode|vagal X placode|vagal epibranchial placodes|nodose placodes|epibranchial placode 3|vagal placode	http://purl.obolibrary.org/obo/UBERON_0009126		
HP:0009310	biolink:PhenotypicFeature	Broad proximal phalanx of the 4th finger	Increased width of the proximal phalanx of the 4th finger.	UMLS:C4020660	hp.json	Broad innermost ring finger bone	http://purl.obolibrary.org/obo/HP_0009310		
UBERON:0009127	biolink:AnatomicalEntity	epibranchial ganglion	Cranial ganglion which develops from an epibranchial placode.	ZFA:0001555|TAO:0001555	hp.json	epibranchial ganglia	http://purl.obolibrary.org/obo/UBERON_0009127		
HP:0010360	biolink:PhenotypicFeature	Broad phalanges of the 3rd toe		UMLS:C4023881	hp.json	Wide bones of 3rd toe	http://purl.obolibrary.org/obo/HP_0010360		
HP:0009371	biolink:PhenotypicFeature	Type A1 brachydactyly		UMLS:C1862151|MSH:C537088|SNOMEDCT_US:715720006	hp.json		http://purl.obolibrary.org/obo/HP_0009371		
dc:title	biolink:NamedThing	title		http://purl.org/dc/elements/1.1/title	hp.json		http://purl.org/dc/elements/1.1/title		
HP:0009370	biolink:PhenotypicFeature	Type A brachydactyly		UMLS:C4024413	hp.json		http://purl.obolibrary.org/obo/HP_0009370		
UBERON:0009191	biolink:AnatomicalEntity	sphenoid bone pre-cartilage condensation	A sphenoid endochondral element that is composed primarily of a pre-cartilage condensation.	EMAPA:18015|EHDAA2:0003446	hp.json		http://purl.obolibrary.org/obo/UBERON_0009191		
HP:0009373	biolink:PhenotypicFeature	Type C brachydactyly		MSH:C537093|UMLS:C1862103	hp.json		http://purl.obolibrary.org/obo/HP_0009373		
HP:0009372	biolink:PhenotypicFeature	Type A2 brachydactyly		MSH:C537089|UMLS:C1832702	hp.json	Short index fingers and second toes	http://purl.obolibrary.org/obo/HP_0009372		
UBERON:0009193	biolink:AnatomicalEntity	sphenoid cartilage element	A sphenoid endochondral element that is composed primarily of cartilage tissue.	EHDAA2:0001888	hp.json	sphenoid bone cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0009193		
UBERON:0010183	biolink:AnatomicalEntity	liver trabecula	A trabecula that is part of a liver.		hp.json	liver trabeculae|hepatic trabecula	http://purl.obolibrary.org/obo/UBERON_0010183		
UBERON:0009196	biolink:AnatomicalEntity	indifferent external genitalia		EHDAA2:0004021	hp.json		http://purl.obolibrary.org/obo/UBERON_0009196		organ_slim
HP:0010368	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the 3rd toe		UMLS:C4023878	hp.json	Abnormality of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010368		
UBERON:0010186	biolink:AnatomicalEntity	male urethral gland	Any of the numerous small mucous-secreting glands located in the wall of the penile urethra.	FMA:21443|EMAPA:29645|UMLS:C1314737|NCIT:C49311	hp.json	gland of male urethra|glandulae urethrales urethrae masculinae|urethral gland (male)|Littre's gland|gland of Littre|male urethra gland	http://purl.obolibrary.org/obo/UBERON_0010186		pheno_slim
HP:0010367	biolink:PhenotypicFeature	Duplication of phalanx of the 3rd toe	Partial or complete duplication of phalanx of third toe.	UMLS:C4021282	hp.json	Partial/complete duplication of the phalanges of the 3rd toe|Duplication of phalanx of the third toe|Duplication of 3rd toe bone	http://purl.obolibrary.org/obo/HP_0010367		
UBERON:0010187	biolink:AnatomicalEntity	female urethral gland	An urethral gland that is part of a female urethra.	FMA:21444|EMAPA:29653	hp.json	gland of female urethra|urethral gland (female)|female urethra gland	http://purl.obolibrary.org/obo/UBERON_0010187		
HP:0010366	biolink:PhenotypicFeature	Triangular shaped phalanges of the 3rd toe		UMLS:C4023879	hp.json	Triangular shaped 3rd toe bones	http://purl.obolibrary.org/obo/HP_0010366		
HP:0010365	biolink:PhenotypicFeature	Symphalangism affecting the phalanges of the 3rd toe		UMLS:C4023880	hp.json	Fused bones of 3rd toe	http://purl.obolibrary.org/obo/HP_0010365		
HP:0010364	biolink:PhenotypicFeature	Patchy sclerosis of 3rd toe phalanx	Patchy (irregular) increase in bone density of one or more of the phalanges of the third toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4021283	hp.json	Uneven increase in bone density in 3rd toe bone|Patchy sclerosis of the phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010364		
HP:0010363	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the 3rd toe		UMLS:C4021825	hp.json		http://purl.obolibrary.org/obo/HP_0010363		
HP:0010362	biolink:PhenotypicFeature	Curved 3rd toe phalanx	A deviation from the normal straight form of one or more phalanges of the third toe.	UMLS:C4021284	hp.json	Curved bones of 3rd toe|Curved phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010362		
UBERON:0010188	biolink:AnatomicalEntity	protuberance	A roughly circular bulge in a surface.	EHDAA2:0003250|FMA:82506|AEO:0000205	hp.json		http://purl.obolibrary.org/obo/UBERON_0010188		
UBERON:0010189	biolink:AnatomicalEntity	right atrium venous valve		EMAPA:17328|MA:0001872|EHDAA2:0001762|EMAPA:17010	hp.json	right venous valve	http://purl.obolibrary.org/obo/UBERON_0010189		
HP:0010361	biolink:PhenotypicFeature	Bullet-shaped 3rd toe phalanx	An abnormal morphology of one or more phalanges of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021285	hp.json	Bullet-shaped phalanges of the 3rd toe|Bullet-shaped bones of 3rd toe	http://purl.obolibrary.org/obo/HP_0010361		
HP:4000081	biolink:PhenotypicFeature	Reduced use of typical gestures	A diminished use of typical non-verbal conversational gestures such as shaing the head to indicate no or nodding the head to indicate yes.		hp.json		http://purl.obolibrary.org/obo/HP_4000081		
HP:4000082	biolink:PhenotypicFeature	Reduced collaborative play	Impairment in a child's ability to be able to play in a way that involves peer collaboration. Collaborative play involves things such as verbal and non-verbal communication (e.g., self-initiated interactions), turn-taking, sharing, reciprocity, and collaborative problem-solving. It is often contrasted to parallel play, which involves a form of social play in which two children do similar activities near each other and often mimic each other. Typically developing children develop collaborative play between the ages of 4 and 5.		hp.json		http://purl.obolibrary.org/obo/HP_4000082		
HP:0010369	biolink:PhenotypicFeature	Abnormality of the middle phalanx of the 3rd toe		UMLS:C4023877	hp.json	Abnormality of the middle bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0010369		
HP:4000080	biolink:PhenotypicFeature	Lack of social initiations	Failure of a person to initiate social interactions with others. For a social interaction to have been initiated by someone, there must have been an absence of social interactions from either party for a period. The interaction must also be unprompted from another party.		hp.json		http://purl.obolibrary.org/obo/HP_4000080		
HP:4000085	biolink:PhenotypicFeature	Reduced object sharing	An absence or reduction in object sharing. Object sharing is an early emerging social skill in which a child will share objects with parents or peers during object play. Object sharing typically develops within the first two years of life.		hp.json		http://purl.obolibrary.org/obo/HP_4000085		
UBERON:0009198	biolink:AnatomicalEntity	craniofacial suture	Any suture between cranial and/or facial bones.		hp.json	joint of the skull bones|articulation of skull bones	http://purl.obolibrary.org/obo/UBERON_0009198		
UBERON:0009199	biolink:AnatomicalEntity	facial suture	Any suture between facial bones.		hp.json		http://purl.obolibrary.org/obo/UBERON_0009199		
HP:4000083	biolink:PhenotypicFeature	Absence of interest in peers	Lack of interest of an individual for peers of comparable age and social groups.		hp.json		http://purl.obolibrary.org/obo/HP_4000083		
HP:4000084	biolink:PhenotypicFeature	Reduced sharing of interests	Decreased sharing of interests with others.		hp.json		http://purl.obolibrary.org/obo/HP_4000084		
HP:4000089	biolink:PhenotypicFeature	Atypical facial expressions	Spontaneous production of communicative facial expressions that have poor quality or are perceived as odd or mechanical. This may include inaccurate mimicry of typical facial expressions.		hp.json		http://purl.obolibrary.org/obo/HP_4000089		
HP:4000087	biolink:PhenotypicFeature	Abnormal facial expressions	Abnormal expressions (movements or position of muscles of the face that convey the emotional state of an individual to observers) comprising abnormalities of quantity, range, context-appropriateness, and quality.		hp.json	Abnormal communicative facial expressions	http://purl.obolibrary.org/obo/HP_4000087		
HP:4000088	biolink:PhenotypicFeature	Context-inappropriate facial expressions	Production of facial expressions that are misaligned with the social context.		hp.json		http://purl.obolibrary.org/obo/HP_4000088		
HP:0009382	biolink:PhenotypicFeature	Absent epiphyses of the 5th finger	Absence of one or more epiphyses of the 5th finger.	UMLS:C4024407	hp.json	Absent end part of little finger bone|Absent end part of pinky finger bone|Absent end part of pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009382		
HP:0009381	biolink:PhenotypicFeature	Short finger	Abnormally short finger associated with developmental hypoplasia.	UMLS:C0239594|UMLS:C1844548|SNOMEDCT_US:249765007	hp.json	Hypoplastic/small fingers|Stubby finger|Hypoplastic fingers|Stubby fingers|Hypoplastic digits|Short finger	http://purl.obolibrary.org/obo/HP_0009381		hposlim_core
HP:0009384	biolink:PhenotypicFeature	Cone-shaped epiphyses of the 5th finger	A cone-shaped appearance of the epiphyses of the 5th finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.	UMLS:C4024405	hp.json	Cone-shaped end part of the pinky finger bones|Cone-shaped end part of the pinkie finger bones|Cone-shaped end part of the little finger bones	http://purl.obolibrary.org/obo/HP_0009384		
HP:0009383	biolink:PhenotypicFeature	Bracket epiphyses of the 5th finger	An abnormality of the fifth finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024406	hp.json	Bracket shaped end part of pinky finger bone|Bracket shaped end part of little finger bone|Bracket shaped end part of pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009383		
UBERON:0010171	biolink:AnatomicalEntity	strand of hair of face	A strand of hair that is part of a face.	FMA:54360	hp.json	facial hair|face hair strand|hair of face|face hair	http://purl.obolibrary.org/obo/UBERON_0010171		pheno_slim
UBERON:0010172	biolink:AnatomicalEntity	bulb of aorta	The portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles.	BTO:0004695|FMA:3740	hp.json	aortic bulb|aortic root|aorta bulb|bulb of ascending aorta|root of aorta|supraaortic valve area|bulbus aortae	http://purl.obolibrary.org/obo/UBERON_0010172		pheno_slim
HP:0009380	biolink:PhenotypicFeature	Aplasia of the fingers	Aplasia of one or more fingers.	SNOMEDCT_US:71358006|UMLS:C0728895	hp.json	Absent fingers	http://purl.obolibrary.org/obo/HP_0009380		
HP:0010357	biolink:PhenotypicFeature	Abnormality of the middle phalanx of the 2nd toe		UMLS:C4023884	hp.json	Abnormality of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010357		
HP:0010356	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the 2nd toe		UMLS:C4023885	hp.json	Abnormality of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010356		
HP:0010355	biolink:PhenotypicFeature	Duplication of the phalanges of the 2nd toe	Partial or complete duplication of a phalanx of second toe.	UMLS:C4021286	hp.json	Partial/complete duplication of the phalanges of the 2nd toe|Duplication of the bones of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010355		
HP:0010354	biolink:PhenotypicFeature	Triangular shaped phalanges of the 2nd toe		UMLS:C4023886	hp.json	Triangular shaped bone of 2nd toe|Triangular shaped bone of second toe	http://purl.obolibrary.org/obo/HP_0010354		
HP:0010353	biolink:PhenotypicFeature	Second toe symphalangism	Fusion of the interphalangeal joints of the 2nd toe.	UMLS:C4023887	hp.json	Fused bones of 2nd toe|2nd toe symphalangism|Symphalangism affecting the phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010353		
HP:0010352	biolink:PhenotypicFeature	Patchy sclerosis of 2nd toe phalanx	Patchy (irregular) increase in bone density of one or more of the phalanges of the second toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4021287	hp.json	Uneven increase in bone density in 2nd toe bone|Patchy sclerosis of the phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010352		
HP:0010351	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the 2nd toe		UMLS:C4023888	hp.json		http://purl.obolibrary.org/obo/HP_0010351		
HP:0010350	biolink:PhenotypicFeature	Curved 2nd toe phalanx	A deviation from the normal straight form of one or more phalanges of the second toe.	UMLS:C4021288	hp.json	Curved bones of the 2nd toe|Curved phalanges of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010350		
HP:4000070	biolink:PhenotypicFeature	Circumscribed interests	Highly restricted, fixated interests that are abnormal in intensity or focus (e.g., strong attachment to or preoccupation with unusual objects, excessively circumscribed or perseverative interests).		hp.json	Restricted interests	http://purl.obolibrary.org/obo/HP_4000070		
HP:0010359	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the 3rd toe		UMLS:C4023882	hp.json	Absent/small bones of 3rd toe|Absent/underdeveloped bones of 3rd toe	http://purl.obolibrary.org/obo/HP_0010359		
HP:0010358	biolink:PhenotypicFeature	Abnormal morphology of the proximal phalanx of the 2nd toe		UMLS:C4023883	hp.json	Abnormality of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010358		
HP:0009379	biolink:PhenotypicFeature	Rhomboid or triangular shaped 5th finger distal phalanx	Rhomboid or triangular shaped 5th (little) finger distal phalanx.	UMLS:C4024408	hp.json	Rhomboid or triangular shaped little finger bone|Rhomboid or triangular shaped pinkie finger bone|Rhomboid or triangular shaped pinky finger bone	http://purl.obolibrary.org/obo/HP_0009379		
HP:4000074	biolink:PhenotypicFeature	Idiosyncratic language	Inappropriate use of words that have no phonological or semantic similarity to the intended word.		hp.json		http://purl.obolibrary.org/obo/HP_4000074		
HP:0009378	biolink:PhenotypicFeature	Triangular shaped phalanges of the 5th finger	Triangular shaped phalanges of the 5th (little) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024409	hp.json	Triangular shaped little finger bones|Triangular shaped pinky finger bones|Triangular shaped pinkie finger bones	http://purl.obolibrary.org/obo/HP_0009378		
HP:4000075	biolink:PhenotypicFeature	Reduced production of facial expressions	A behavioral abnormality marked by reduced use of communicative facial expressions. This may include individuals with a reduced range of facial expressions or those with a full range but who use them at a decreased rate.		hp.json		http://purl.obolibrary.org/obo/HP_4000075		
HP:4000072	biolink:PhenotypicFeature	Abnormal verbal communicative behavior	Any abnormal behavior related to communication with language.		hp.json		http://purl.obolibrary.org/obo/HP_4000072		
HP:4000073	biolink:PhenotypicFeature	Pronoun reversal	A type of language impairment in which incorrect pronouns are used; i.e., using 'I' for 'you' and/or 'you' for 'I' (e.g., a child saying 'You want some more milk' meaning 'I want some more milk'). Reversal errors involve the person component, such that 'I' and 'you' become confused.		hp.json		http://purl.obolibrary.org/obo/HP_4000073		
HP:0009375	biolink:PhenotypicFeature	Bullet-shaped phalanges of the 5th finger	A fifth finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4024411	hp.json	Bullet-shaped pinky finger bones|Bullet-shaped pinkie finger bones|Bullet-shaped little finger bones	http://purl.obolibrary.org/obo/HP_0009375		
HP:4000078	biolink:PhenotypicFeature	Fixated interest with abnormal intensity	An abnormally intense interest in a topic or object that is not atypical for the social context of the affected person.		hp.json		http://purl.obolibrary.org/obo/HP_4000078		
HP:4000079	biolink:PhenotypicFeature	Sensory seeking	Unusual interest in sensory aspects of the environment.		hp.json		http://purl.obolibrary.org/obo/HP_4000079		
HP:0009374	biolink:PhenotypicFeature	Broad phalanges of the 5th finger	Increased width of the phalanges of the 5th finger.	UMLS:C4024412	hp.json	Broad pinkie finger bones|Broad little finger bones|Broad pinky finger bones	http://purl.obolibrary.org/obo/HP_0009374		
HP:0009377	biolink:PhenotypicFeature	Patchy sclerosis of 5th finger phalanx	Uneven increase in bone density of one or more of the phalanges of the 5th finger.	UMLS:C4021484	hp.json	Uneven increase in bone density in pinky finger bone|Patchy sclerosis of the phalanges of the 5th finger|Uneven increase in bone density in little finger bone|Uneven increase in bone density in pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009377		
HP:4000076	biolink:PhenotypicFeature	Hand-leading gestures	Taking other people by the hand to places they wish them to move to or taking someone's hand to objects they want them to manipulate.		hp.json	Hand-taking gestures	http://purl.obolibrary.org/obo/HP_4000076		
HP:0009376	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the 5th finger	Aplasia/Hypoplasia of the phalanges of the 5th finger.	UMLS:C4024410	hp.json	Absent/underdeveloped pinky finger bones|Absent/small pinkie finger bones|Absent/small pinky finger bones|Absent/small little finger bones	http://purl.obolibrary.org/obo/HP_0009376		
HP:4000077	biolink:PhenotypicFeature	Fixated interest with abnormal focus	A fixated interest in a specific topic that is atypical for the social context of the individual, such as topics of a non-social nature like fossils or vacuum cleaners.		hp.json		http://purl.obolibrary.org/obo/HP_4000077		
HP:4000069	biolink:PhenotypicFeature	Persistent preoccupation with parts of objects	A type of abnormal interest characterized by a persistent and intense focus in parts of a toy/object. For examples, affected individuals may spin the wheels on a toy car rather than driving the toy car.		hp.json		http://purl.obolibrary.org/obo/HP_4000069		
HP:0009351	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the 3rd finger	Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 3rd finger.	UMLS:C4024418	hp.json	Irregular end part of innermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009351		
HP:0009350	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the 3rd finger	Fragmented appearance of the epiphysis of the proximal phalanx of the 3rd finger.	UMLS:C4024419	hp.json	Fragmentation of end part of innermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009350		
UBERON:0010160	biolink:AnatomicalEntity	lumen of lymphatic vessel	An anatomical cavity that surrounded_by a lymphatic vessel.	FMA:59681	hp.json	lymphatic vessel lumen|lumen of lymphatic duct	http://purl.obolibrary.org/obo/UBERON_0010160		
UBERON:0010161	biolink:AnatomicalEntity	lumen of blood vessel	An anatomical cavity that surrounded_by a blood vessel.	FMA:312610|SCTID:91747007	hp.json	blood vessel lumen	http://purl.obolibrary.org/obo/UBERON_0010161		
UBERON:0010164	biolink:AnatomicalEntity	collection of hairs	An anatomical cluster that composed_primarily_of a strand of hair.	FMA:70752	hp.json	hairs|pili|set of hairs|hairs set	http://purl.obolibrary.org/obo/UBERON_0010164		
HP:0010345	biolink:PhenotypicFeature	Flexion contracture of the 5th toe	One or more bent (flexed) joints of the fifth toe that cannot be straightened actively or passively.	UMLS:C4021290	hp.json	Joint contractures of the 5th toe	http://purl.obolibrary.org/obo/HP_0010345		
UBERON:0010165	biolink:AnatomicalEntity	collection of hair on face	A collection of hairs that is part of a face.	FMA:70741	hp.json	facial hairs set|facial hair|set of facial hairs	http://purl.obolibrary.org/obo/UBERON_0010165		phenotype_rcn
UBERON:0010162	biolink:AnatomicalEntity	post-anal tail tip	The distal end of the tail.	MA:0002848|EMAPA:37760|XAO:0004057	hp.json	end of tail|tail tip	http://purl.obolibrary.org/obo/UBERON_0010162		pheno_slim
HP:0010344	biolink:PhenotypicFeature	Deviation of the 5th toe		UMLS:C4021291	hp.json	Displacement of the 5th toe|Displacement of the pinkie toe|Displacement of the little toe|Displacement of the pinky toe	http://purl.obolibrary.org/obo/HP_0010344		
UBERON:0010163	biolink:AnatomicalEntity	eyebrow	The eyebrow is an area of thick, delicate hairs above the eye that follows the shape of the lower margin of the brow ridges. Their main function is to protect the eye, but they are also important to human communication and facial expression. It is not uncommon for people to modify their eyebrows by means of hair addition or removal, make up, or piercings.	FMA:54237|UMLS:C0015420|NCIT:C32575|MESH:D005138	hp.json	supercilium	http://purl.obolibrary.org/obo/UBERON_0010163		phenotype_rcn|pheno_slim
HP:0010343	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 5th toe		UMLS:C4023891	hp.json	Absent/underdeveloped pinky toe|Absent/small little toe|Absent/small pinky toe|Absent/small pinkie toe	http://purl.obolibrary.org/obo/HP_0010343		
HP:0010342	biolink:PhenotypicFeature	Abnormality of the phalanges of the 5th toe		UMLS:C4023892	hp.json	Abnormality of the pinkie toe bones|Abnormality of the pinky toe bones|Abnormality of the little toe bones	http://purl.obolibrary.org/obo/HP_0010342		
UBERON:0010168	biolink:AnatomicalEntity	collection of eyelashes	A collection of hair on face that is part of a eyelash.	FMA:70742	hp.json	cilia|set of eyelashes|eyelashes set|eyelashes	http://purl.obolibrary.org/obo/UBERON_0010168		
HP:0010341	biolink:PhenotypicFeature	Abnormality of the epiphyses of the 5th toe		UMLS:C4023893	hp.json	Abnormality of the end part of the little toe bone|Abnormality of the end part of the pinky toe bone|Abnormality of the end part of the pinkie toe bone	http://purl.obolibrary.org/obo/HP_0010341		
HP:0010340	biolink:PhenotypicFeature	Polydactyly affecting the 4th toe		UMLS:C4023894	hp.json		http://purl.obolibrary.org/obo/HP_0010340		
HP:0010349	biolink:PhenotypicFeature	Bullet-shaped 2nd toe phalanx	An abnormal morphology of one or more phalanges of the second toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021289	hp.json	Bullet-shaped phalanges of the 2nd toe|Bullet-shaped bones of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010349		
HP:0009349	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the 3rd finger	Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger with respect to age-dependent norms.	UMLS:C4021488	hp.json	Enlarged end part of innermost long bone of the middle finger|Large epiphysis of proximal middle-finger phalanx	http://purl.obolibrary.org/obo/HP_0009349		
HP:4000060	biolink:PhenotypicFeature	Abnormal pulmonary alveolar system development			hp.json		http://purl.obolibrary.org/obo/HP_4000060		
HP:0010348	biolink:PhenotypicFeature	Broad phalanges of the 2nd toe		UMLS:C4023889	hp.json	Broad bones of the 2nd toe	http://purl.obolibrary.org/obo/HP_0010348		
HP:0010347	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the 2nd toe		UMLS:C4023890	hp.json	Absent/small bones of 2nd toe|Absent/underdeveloped bones of 2nd toe	http://purl.obolibrary.org/obo/HP_0010347		
HP:0009346	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the 3rd finger	Absence of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger.	UMLS:C4024422	hp.json	Absent end part of innermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009346		
HP:0009345	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the 3rd finger	A triangular appearance of the epiphysis of the distal phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4021489	hp.json	Triangular end part of the outermost long bone of the middle finger|Delta-shaped epiphysis of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009345		
HP:0009348	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the 3rd finger	A cone-shaped appearance of the epiphysis of the proximal phalanx of the 3rd finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4024420	hp.json	Cone-shaped end part of the innermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009348		
HP:4000061	biolink:PhenotypicFeature	Pancreatic alpha-cell hyperplasia	A diffuse and specific increase in the number of alpha-cells.		hp.json		http://purl.obolibrary.org/obo/HP_4000061		
HP:0009347	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the 3rd finger	An abnormality of the proximal phalanx of the third finger in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024421	hp.json	Bracket shaped end part of innermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009347		
HP:4000062	biolink:PhenotypicFeature	3-4 metacarpal synostosis	A congenital hand malformation characterized by the coalescence of the coalescence of third and fourth metacarpals (i.e., those corresponding to the middle and ring fingers).		hp.json	Synostosis of third and the fourth metacarpal bones|Fused third and fourth metacarpals|Middle and ring finger metacarpal synostosis	http://purl.obolibrary.org/obo/HP_4000062		
HP:0009342	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the 3rd finger	A secondary ossification center in the distal phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024425	hp.json	Pseudoepiphysis of the outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009342		
HP:4000067	biolink:PhenotypicFeature	Iliac artery aneurysm	Abnormal outpouching or sac-like dilatation in the iliac artery.		hp.json		http://purl.obolibrary.org/obo/HP_4000067		
HP:4000068	biolink:PhenotypicFeature	Abnormal interest	Any deviation from normal intensity or subject of a person's interests, which can be defined as a state of giving selective attention to something.		hp.json		http://purl.obolibrary.org/obo/HP_4000068		
HP:0009341	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the 3rd finger	Sclerosis of the epiphysis of the distal phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024426	hp.json	Increased bone density of end part of the outermost middle finger bone	http://purl.obolibrary.org/obo/HP_0009341		
HP:0009344	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the 3rd finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 3rd finger.	UMLS:C4024423	hp.json	Speckled calcifications in end part of the outermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009344		
HP:4000066	biolink:PhenotypicFeature	Abnormal iliac artery morphology	Any structural anomaly of the iliac artery.		hp.json		http://purl.obolibrary.org/obo/HP_4000066		
HP:0009343	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the 3rd finger	Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the 3rd finger with respect to age-dependent norms.	UMLS:C4024424	hp.json	Small end part of the outermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009343		
HP:4000058	biolink:PhenotypicFeature	Glomerular proteinuria	A type of proteinuria characterized by increased permeability of the glomerular capillary wall to macromolecules (particularly albumin), whereby protein excretion can reach 20 g/24 h and consists mainly of albumin.  PMID: 19634399		hp.json		http://purl.obolibrary.org/obo/HP_4000058		
HP:4000059	biolink:PhenotypicFeature	Abnormal lung development	A structural defect associated with abnormal development of the lung.		hp.json	Developmental pulmonary anomaly	http://purl.obolibrary.org/obo/HP_4000059		
HP:0010335	biolink:PhenotypicFeature	Abnormality of the epiphyses of the 4th toe		UMLS:C4023897	hp.json	Abnormality of the end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0010335		
HP:0010334	biolink:PhenotypicFeature	Polydactyly affecting the 3rd toe		UMLS:C4023898	hp.json		http://purl.obolibrary.org/obo/HP_0010334		
HP:0010333	biolink:PhenotypicFeature	Flexion contracture of 3rd toe	One or more bent (flexed) joints of the third toe that cannot be straightened actively or passively.	UMLS:C4021294	hp.json	Joint contractures of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010333		
UBERON:0010152	biolink:AnatomicalEntity	skin mucus	A mucous secretion that is produced by glands in the epidermis.		hp.json	epidermal mucus|skin mucous	http://purl.obolibrary.org/obo/UBERON_0010152		
HP:0010332	biolink:PhenotypicFeature	Deviation of the 3rd toe		UMLS:C4021295	hp.json	Displacement of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010332		
HP:0010331	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 3rd toe		UMLS:C1862698	hp.json	Absent/underdeveloped 3rd toe|Absent/hypoplastic third toe|Absent/small 3rd toe	http://purl.obolibrary.org/obo/HP_0010331		
UBERON:0010157	biolink:AnatomicalEntity	sphenoparietal suture	The Sphenoparietal suture is the cranial suture between the sphenoid bone and the parietal bone.	FMA:52945	hp.json	sutura sphenoparietalis|spheno-parietal suture|sphenoparietal suture of skull	http://purl.obolibrary.org/obo/UBERON_0010157		
HP:0010330	biolink:PhenotypicFeature	Abnormality of the phalanges of the 3rd toe		UMLS:C4023899	hp.json	Abnormality of the bones of the 3rd toe	http://purl.obolibrary.org/obo/HP_0010330		
UBERON:0010158	biolink:AnatomicalEntity	sphenozygomatic suture	The Sphenozygomatic suture is the cranial suture between the sphenoid bone and the zygomatic bone.	FMA:52956	hp.json	sphenozygomatica suture of skull|sutura sphenozygomatica	http://purl.obolibrary.org/obo/UBERON_0010158		
UBERON:0010155	biolink:AnatomicalEntity	parietomastoid suture	Unites the mastoid process of the temporal with the region of the mastoid angle of the parietal[WP:Squamosal_suture].	FMA:52947	hp.json	parieto-mastoid suture of skull|parietomastoid suture of skull	http://purl.obolibrary.org/obo/UBERON_0010155		
UBERON:0010156	biolink:AnatomicalEntity	sphenofrontal suture	The Sphenofrontal suture is the cranial suture between the sphenoid bone and the frontal bone.	FMA:52938	hp.json	sutura sphenofrontalis|frontosphenoid suture|sphenofrontal suture of skull|sphenofrontal|sutura sphenofrontalis|spheno-frontal suture	http://purl.obolibrary.org/obo/UBERON_0010156		
HP:0010339	biolink:PhenotypicFeature	Flexion contracture of the 4th toe	One or more bent (flexed) joints of the fourth toe that cannot be straightened actively or passively.	UMLS:C4021292	hp.json	Joint contractures of the 4th toe	http://purl.obolibrary.org/obo/HP_0010339		
HP:0010338	biolink:PhenotypicFeature	Deviation of the 4th toe		UMLS:C4021293	hp.json	Displacement of the 4th toe	http://purl.obolibrary.org/obo/HP_0010338		
HP:0010337	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 4th toe		UMLS:C4023895	hp.json	Absent/underdeveloped 4th toe|Absent/small 4th toe	http://purl.obolibrary.org/obo/HP_0010337		
HP:0010336	biolink:PhenotypicFeature	Abnormality of the phalanges of the 4th toe		UMLS:C4023896	hp.json		http://purl.obolibrary.org/obo/HP_0010336		
HP:4000052	biolink:PhenotypicFeature	Avulsion fracture	A type of fracture that is localied near to a a tendon or ligament and a small fragment of bone is separated from the main mass of bone as a result of physical trauma.		hp.json		http://purl.obolibrary.org/obo/HP_4000052		
HP:0009357	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the 3rd finger		UMLS:C4021486	hp.json	Abnormality of the outermost bone of the 3rd finger|Abnormality of terminal phalanx of middle-finger	http://purl.obolibrary.org/obo/HP_0009357		
HP:4000053	biolink:PhenotypicFeature	Displaced fracture	A type of fracture in which the ends of the fractured bone are no longer aligned.		hp.json		http://purl.obolibrary.org/obo/HP_4000053		
HP:0009356	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the 3rd finger	A triangular appearance of the epiphysis of the proximal phalanx of the 3rd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4021487	hp.json	Delta-shaped epiphysis of the proximal phalanx of the 3rd finger|Triangular end part of innermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009356		
HP:4000050	biolink:PhenotypicFeature	Open fracture	A type of fracture in which there is an open wound or break in the skin near the site of the broken bone.		hp.json	Compound fracture	http://purl.obolibrary.org/obo/HP_4000050		
HP:4000051	biolink:PhenotypicFeature	Closed fracture	A type of fracture in which the broken bone that does not penetrate the skin.		hp.json		http://purl.obolibrary.org/obo/HP_4000051		
HP:0009358	biolink:PhenotypicFeature	Abnormality of the proximal phalanx of the 3rd finger		UMLS:C4021485	hp.json	Abnormality of proximal middle-finger phalanx|Abnormal innermost bone of middle finger	http://purl.obolibrary.org/obo/HP_0009358		
HP:4000056	biolink:PhenotypicFeature	Abnormal apoptosis	Any abnormality of programmed cell death (apoptosis), which is defined as the orchestrated collapse of a cell characterised by membrane blebbing, cell shrinkage, condensation of chromatin, and fragmentation of DNA followed by rapid engulfment of the corpse by neighbouring cells. Apoptosis is distinguished from death by necrosis by the absence of an associated inflammatory response.		hp.json		http://purl.obolibrary.org/obo/HP_4000056		
HP:0009353	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the 3rd finger	A secondary ossification center in the proximal phalanx of the third finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024416	hp.json		http://purl.obolibrary.org/obo/HP_0009353		
HP:4000057	biolink:PhenotypicFeature	Decreased FasL-mediated apoptosis	A reduced amount of programmed cell death upon stimulation of the FAS receptor, which normally induces caspase-8 dependent apoptosis.		hp.json		http://purl.obolibrary.org/obo/HP_4000057		
HP:0009352	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the 3rd finger	Sclerosis of the epiphysis of the proximal phalanx of the 3rd finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024417	hp.json	Increased bone density of end part of the innermost middle finger bone	http://purl.obolibrary.org/obo/HP_0009352		
HP:4000054	biolink:PhenotypicFeature	Exanthem	A widespread rash.		hp.json		http://purl.obolibrary.org/obo/HP_4000054		
HP:0009355	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the 3rd finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 3rd finger.	UMLS:C4024414	hp.json	Speckled calcifications in end part of innermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009355		
HP:4000055	biolink:PhenotypicFeature	Intestinal inflammation	A reaction characterizeds by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling localized to the in the intestinal tract.		hp.json		http://purl.obolibrary.org/obo/HP_4000055		
HP:0009354	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the 3rd finger	Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 3rd finger with respect to age-dependent norms.	UMLS:C4024415	hp.json	Small end part of innermost long bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009354		
HP:0000918	biolink:PhenotypicFeature	Scapular exostoses	The presence of multiple exostoses on the scapula. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage.	UMLS:C1851415	hp.json	Shoulder bone exostoes|Scapulae exostoses	http://purl.obolibrary.org/obo/HP_0000918		
GO:0001653	biolink:MolecularActivity	peptide receptor activity	Combining with an extracellular or intracellular peptide to initiate a change in cell activity.		hp.json	endogenous peptide receptor activity|exogenous peptide receptor activity	http://purl.obolibrary.org/obo/GO_0001653		
HP:0000917	biolink:PhenotypicFeature	Superior pectus carinatum	Pectus carinatum affecting primarily the superior part of the sternum.	UMLS:C1864795	hp.json	Pectus carinatum superiorly	http://purl.obolibrary.org/obo/HP_0000917		
GO:0001654	biolink:BiologicalProcess	eye development	The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.	Wikipedia:Eye_development	hp.json		http://purl.obolibrary.org/obo/GO_0001654		
GO:0001655	biolink:BiologicalProcess	urogenital system development	The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0001655		
HP:0000919	biolink:PhenotypicFeature	Abnormality of the costochondral junction	Any anomaly of the costochondral junction. The costochondral junctions are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum.	UMLS:C4021791	hp.json	Costochondral juctions abnormal	http://purl.obolibrary.org/obo/HP_0000919		
HP:0000910	biolink:PhenotypicFeature	Wide-cupped costochondral junctions		UMLS:C1861213	hp.json		http://purl.obolibrary.org/obo/HP_0000910		
HP:0000912	biolink:PhenotypicFeature	Sprengel anomaly	A congenital skeletal deformity characterized by the elevation of one scapula (thus, one scapula is located superior to the other).	MEDDRA:10010455|UMLS:C0152438|MSH:C535802|SNOMEDCT_US:79120002	hp.json	High shoulder blade|Congenital, upward displacement of the scapula|Sprengel deformity|High scapula	http://purl.obolibrary.org/obo/HP_0000912		hposlim_core
HP:0000911	biolink:PhenotypicFeature	Flat glenoid fossa	Abnormally flat configuration of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus.	UMLS:C1855177	hp.json		http://purl.obolibrary.org/obo/HP_0000911		
HP:0000914	biolink:PhenotypicFeature	Shield chest	A broad chest.	UMLS:C1834124|UMLS:C1839248	hp.json	Shield chest|Broad chest	http://purl.obolibrary.org/obo/HP_0000914		
HP:0000913	biolink:PhenotypicFeature	Posterior rib fusion	Complete or partial merging of the posterior part of adjacent ribs.	UMLS:C1842084	hp.json		http://purl.obolibrary.org/obo/HP_0000913		
HP:0000916	biolink:PhenotypicFeature	Broad clavicles	Increased width (cross-sectional diameter) of the clavicles.	SNOMEDCT_US:249680009|UMLS:C0426801	hp.json	Broad collarbone	http://purl.obolibrary.org/obo/HP_0000916		hposlim_core
CHEBI:27594	biolink:ChemicalSubstance	carbon atom		KEGG:C06265|WebElements:C|CAS:7440-44-0|CAS:7440-44-0	hp.json	carbone|carbonium|C|Carbon|carbono|carbon|6C|Kohlenstoff|carbon|C	http://purl.obolibrary.org/obo/CHEBI_27594		3_STAR
GO:1904795	biolink:BiologicalProcess	positive regulation of euchromatin binding	Any process that activates or increases the frequency, rate or extent of euchromatin binding.		hp.json	up regulation of euchromatin binding|activation of euchromatin binding|upregulation of euchromatin binding|up-regulation of euchromatin binding	http://purl.obolibrary.org/obo/GO_1904795		
HP:0000915	biolink:PhenotypicFeature	Pectus excavatum of inferior sternum	Pectus excavatum (defect of the chest wall characterized by depression of the sternum) affecting primarily the inferior region of the sternum.	UMLS:C1864796	hp.json	Pectus excavatum inferiorly	http://purl.obolibrary.org/obo/HP_0000915		
HP:0012900	biolink:PhenotypicFeature	Myotonia of the face	Slowed relaxation of muscles in the face.	UMLS:C4022686	hp.json		http://purl.obolibrary.org/obo/HP_0012900		
HP:0012901	biolink:PhenotypicFeature	Myotonia of the jaw	Slowed relaxation of muscles in the jaw.	UMLS:C4022685	hp.json		http://purl.obolibrary.org/obo/HP_0012901		
HP:0012902	biolink:PhenotypicFeature	Myotonia of the lower limb	Slowed relaxation of muscles in the leg.	UMLS:C4022684	hp.json		http://purl.obolibrary.org/obo/HP_0012902		
HP:0012903	biolink:PhenotypicFeature	Myotonia of the upper limb	Slowed relaxation of muscles in the arm.	UMLS:C4022683	hp.json		http://purl.obolibrary.org/obo/HP_0012903		
HP:0012904	biolink:PhenotypicFeature	Cold-sensitive myotonia	An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation that is induced by exposure to cold.	UMLS:C4022682	hp.json		http://purl.obolibrary.org/obo/HP_0012904		
HP:0012905	biolink:PhenotypicFeature	Euryblepharon	Euryblepharon is a congenital eyelid anomaly characterized by horizontal enlargement of the palpebral fissure. The eyelid is shortened vertically compared with the horizontal dimension, with associated lateral canthal malpositioning and lateral ectropion abnormally wide lid opening.	UMLS:C1303001|UMLS:C4280305|SNOMEDCT_US:400954002	hp.json	Kabuki syndrome eyelids	http://purl.obolibrary.org/obo/HP_0012905		
GO:0001659	biolink:BiologicalProcess	temperature homeostasis	A homeostatic process in which an organism modulates its internal body temperature.	Wikipedia:Thermoregulation	hp.json	thermoregulation	http://purl.obolibrary.org/obo/GO_0001659		
HP:0000929	biolink:PhenotypicFeature	Abnormal skull morphology	An abnormality of the skull, the bony framework of the head which is comprised of the neurocranium (with eight cranial bones) and the viscerocranium (facial skeleton) that comprises fourteen facial bones with the mandible as its largest bone.	UMLS:C0235942	hp.json	Abnormality of the skull|Abnormality of the skull bones	http://purl.obolibrary.org/obo/HP_0000929		
GO:0001667	biolink:BiologicalProcess	ameboidal-type cell migration	Cell migration that is accomplished by extension and retraction of a pseudopodium.		hp.json	ameboid cell migration|amoeboidal cell migration|amoeboid cell migration	http://purl.obolibrary.org/obo/GO_0001667		
HP:0000921	biolink:PhenotypicFeature	Missing ribs	A developmental anomaly with absence of one or more ribs.	UMLS:C0426816|SNOMEDCT_US:249695006	hp.json	Decreased rib number|Missing ribs|Absent ribs	http://purl.obolibrary.org/obo/HP_0000921		hposlim_core
HP:0000920	biolink:PhenotypicFeature	Enlargement of the costochondral junction	Abnormally increased size of the costochondral junctions, which are located between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum.	UMLS:C1857180	hp.json	Wide costochondral junctions|Enlarged costochondral junctions|Prominent costochondral junction|Costochondral thickening|Widened costochondral junction	http://purl.obolibrary.org/obo/HP_0000920		hposlim_core
HP:0000923	biolink:PhenotypicFeature	Beaded ribs	The presence of a row of multiple rounded expansions (beadlike prominences) at the junction of a rib and its cartilage.	UMLS:C0426824	hp.json		http://purl.obolibrary.org/obo/HP_0000923		
HP:0000922	biolink:PhenotypicFeature	Posterior rib cupping	Wide, concave posterior rib end.	UMLS:C1837483	hp.json	Anterior and posterior rib cupping	http://purl.obolibrary.org/obo/HP_0000922		
HP:0000925	biolink:PhenotypicFeature	Abnormality of the vertebral column	Any abnormality of the vertebral column.	UMLS:C4020882|UMLS:C4021789	hp.json	Abnormal spine|Abnormality of the vertebral column|Abnormality of the spine|Abnormality of the backbone|Abnormal vertebral column	http://purl.obolibrary.org/obo/HP_0000925		hposlim_core
HP:0000924	biolink:PhenotypicFeature	Abnormality of the skeletal system	An abnormality of the skeletal system.	UMLS:C4021790	hp.json	Skeletal abnormalities|Skeletal anomalies|Abnormality of the skeletal system	http://purl.obolibrary.org/obo/HP_0000924		
HP:0000927	biolink:PhenotypicFeature	Abnormality of skeletal maturation	The bones of the skeleton undergo a series of characteristic changes in size, shape, and calcification from fetal life until puberty. An abnormality of this process can include delayed or accelerated skeletal maturation, or deviation of some, but not all bones from the expected patterns of maturation.	UMLS:C4025818	hp.json	Abnormality of skeletal maturation	http://purl.obolibrary.org/obo/HP_0000927		
HP:0000926	biolink:PhenotypicFeature	Platyspondyly	A flattened vertebral body shape with reduced distance between the vertebral endplates.	UMLS:C1844704	hp.json	Flattened vertebrae|Flattened vertebral bodies|Flat vertebral bodies	http://purl.obolibrary.org/obo/HP_0000926		hposlim_core
GO:0098542	biolink:BiologicalProcess	defense response to other organism	Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.		hp.json	defence response to pathogen, incompatible interaction|defence response incompatible interaction|resistance response to pathogen|defense response, incompatible interaction	http://purl.obolibrary.org/obo/GO_0098542		goslim_generic|prokaryote_subset
CHEBI:27570	biolink:ChemicalSubstance	histidine	An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.	PMID:22770225|Wikipedia:Histidine|KNApSAcK:C00001363|CAS:4998-57-6|PMID:17190852|PMID:29286160|Gmelin:3656|Reaxys:84087|Beilstein:84087|KEGG:C00768|PMID:22264337	hp.json	DL-Histidine|histidine|alpha-Amino-1H-imidazole-4-propionic acid|Histidin|histidina|Histidine|2-amino-3-(1H-imidazol-4-yl)propanoic acid	http://purl.obolibrary.org/obo/CHEBI_27570		3_STAR
HP:0000907	biolink:PhenotypicFeature	Anterior rib cupping	Wide, concave anterior rib end.	UMLS:C1846154	hp.json	Anterior cupping of ribs|Anteriorly splayed ribs	http://purl.obolibrary.org/obo/HP_0000907		
CHEBI:27584	biolink:ChemicalSubstance	aldosterone	A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.	Wikipedia:Aldosterone|Beilstein:3224996|Reaxys:3224996|PDBeChem:AS4|KEGG:C01780|HMDB:HMDB0000037|Drug_Central:111|CAS:52-39-1|PMID:10438974|CAS:52-39-1|CAS:52-39-1|DrugBank:DB04630|LINCS:LSM-42770|LIPID_MAPS_instance:LMST02030026	hp.json	(11beta)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al|ALDOSTERONE|11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al|aldosterone|11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al|(+)-aldosterone|Aldosterone	http://purl.obolibrary.org/obo/CHEBI_27584		3_STAR
HP:0000900	biolink:PhenotypicFeature	Thickened ribs	Increased thickness (diameter) of ribs.	SNOMEDCT_US:249699000|UMLS:C0426820	hp.json		http://purl.obolibrary.org/obo/HP_0000900		hposlim_core
HP:0000902	biolink:PhenotypicFeature	Rib fusion	Complete or partial merging of adjacent ribs.	UMLS:C1844749	hp.json	Rib fusion|Fused ribs	http://purl.obolibrary.org/obo/HP_0000902		
HP:0000905	biolink:PhenotypicFeature	Progressive clavicular acroosteolysis	Progressive bone resorption in the distal part of the clavicle.	UMLS:C1837757	hp.json	Progressive acroosteolysis of the clavicle	http://purl.obolibrary.org/obo/HP_0000905		
HP:0000904	biolink:PhenotypicFeature	Flaring of rib cage	The presence of wide, concave anterior rib ends.	UMLS:C1854780	hp.json	Anterior flaring of ribs|Flaring of rib cage	http://purl.obolibrary.org/obo/HP_0000904		
GO:1902173	biolink:BiologicalProcess	negative regulation of keratinocyte apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of keratinocyte apoptotic process.		hp.json	down-regulation of keratinocyte apoptosis|negative regulation of keratinocyte apoptosis|down regulation of keratinocyte apoptotic process|inhibition of keratinocyte apoptosis|inhibition of keratinocyte apoptotic process|down-regulation of keratinocyte apoptotic process|downregulation of keratinocyte apoptosis|down regulation of keratinocyte apoptosis|downregulation of keratinocyte apoptotic process	http://purl.obolibrary.org/obo/GO_1902173		
RO:0019001	biolink:NamedThing	positively regulates characteristic	A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C.	RO:0019001	hp.json		http://purl.obolibrary.org/obo/RO_0019001		
GO:1902174	biolink:BiologicalProcess	positive regulation of keratinocyte apoptotic process	Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process.		hp.json	activation of keratinocyte apoptotic process|activation of keratinocyte apoptosis|upregulation of keratinocyte apoptosis|positive regulation of keratinocyte apoptosis|upregulation of keratinocyte apoptotic process|up regulation of keratinocyte apoptosis|up-regulation of keratinocyte apoptosis|up regulation of keratinocyte apoptotic process|up-regulation of keratinocyte apoptotic process	http://purl.obolibrary.org/obo/GO_1902174		
RO:0019000	biolink:NamedThing	regulates characteristic	A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C.	RO:0019000	hp.json		http://purl.obolibrary.org/obo/RO_0019000		
GO:1902172	biolink:BiologicalProcess	regulation of keratinocyte apoptotic process	Any process that modulates the frequency, rate or extent of keratinocyte apoptotic process.		hp.json	regulation of keratinocyte apoptosis	http://purl.obolibrary.org/obo/GO_1902172		
RO:0019002	biolink:NamedThing	negatively regulates characteristic	A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C.	RO:0019002	hp.json		http://purl.obolibrary.org/obo/RO_0019002		
HP:0000954	biolink:PhenotypicFeature	Single transverse palmar crease	The distal and proximal transverse palmar creases are merged into a single transverse palmar crease.	SNOMEDCT_US:248409006|UMLS:C0424731	hp.json	Simian crease|Transverse palmar crease|Single flexion crease|Simian creases|Single transverse palmar creases|Single palmar crease|Single palmar creases|Simian line	http://purl.obolibrary.org/obo/HP_0000954		hposlim_core
HP:0000953	biolink:PhenotypicFeature	Hyperpigmentation of the skin	A darkening of the skin related to an increase in melanin production and deposition.	MSH:D017495|UMLS:C0162834|SNOMEDCT_US:4830009|SNOMEDCT_US:49765009	hp.json	Increased skin pigmentation|Melanodermia|Cutaneous hyperpigmentation|Patchy darkened skin|Hyperpigmented lesion|Melanoderma|Skin hyperpigmentation	http://purl.obolibrary.org/obo/HP_0000953		
HP:0000956	biolink:PhenotypicFeature	Acanthosis nigricans	A dermatosis characterized by thickened, hyperpigmented plaques, typically on the intertriginous surfaces and neck.	MSH:D000052|SNOMEDCT_US:72129000|UMLS:C0000889|SNOMEDCT_US:402599005	hp.json	Darkened and thickened skin|Keratosis nigricans	http://purl.obolibrary.org/obo/HP_0000956		secondary_consequence
HP:0000958	biolink:PhenotypicFeature	Dry skin	Skin characterized by the lack of natural or normal moisture.	SNOMEDCT_US:16386004|UMLS:C0151908|MEDDRA:10048222|UMLS:C0259817	hp.json	Dry skin|Xerosis	http://purl.obolibrary.org/obo/HP_0000958		hposlim_core
HP:0000957	biolink:PhenotypicFeature	Cafe-au-lait spot	Cafe-au-lait spots are hyperpigmented lesions that can vary in color from light brown to dark brown with smooth borders and having a size of 1.5 cm or more in adults and 0.5 cm or more in children.	UMLS:C0265974|MSH:D019080|UMLS:C0221263|SNOMEDCT_US:51089004|SNOMEDCT_US:201281002	hp.json	Cafe-au-lait macule|Flat light-brown mark on skin|Cafe-au-lait macules|Cafe au lait spots|Birthmark|Cafe-au-lait spots	http://purl.obolibrary.org/obo/HP_0000957		
UBERON:0009117	biolink:AnatomicalEntity	indifferent gonad	A gonad prior to differentiating into a definitive testis or ovary.	EHDAA2:0000716|UMLS:C1512703|NCIT:C34192	hp.json	gonad rudiment	http://purl.obolibrary.org/obo/UBERON_0009117		organ_slim
HP:0000952	biolink:PhenotypicFeature	Jaundice	Yellow pigmentation of the skin due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.	MSH:D007565|SNOMEDCT_US:18165001|UMLS:C0022346	hp.json	Jaundice|Yellowing of the skin|Yellow skin|Icterus	http://purl.obolibrary.org/obo/HP_0000952		
HP:0000951	biolink:PhenotypicFeature	Abnormality of the skin	An abnormality of the skin.	SNOMEDCT_US:199879009|UMLS:C0037268|SNOMEDCT_US:95320005|MSH:D012868|UMLS:C0037274|MSH:D012871	hp.json	Dermatopathy|Dermopathy|Abnormality of the skin|Skin abnormality	http://purl.obolibrary.org/obo/HP_0000951		hposlim_core
UBERON:0009114	biolink:AnatomicalEntity	cervical thymus	A mature thymus that is entirely part of the cervical region.		hp.json		http://purl.obolibrary.org/obo/UBERON_0009114		organ_slim
UBERON:0009115	biolink:AnatomicalEntity	thoracic thymus	A mature thymus that is entirely part of thoracic region.		hp.json		http://purl.obolibrary.org/obo/UBERON_0009115		organ_slim
HP:0000965	biolink:PhenotypicFeature	Cutis marmorata	A reticular discoloration of the skin with cyanotic (reddish-blue appearing) areas surrounding pale central areas due to dilation of capillary blood vessels and stagnation of blood within the vessels. Cutis marmorata generally occurs on the legs, arms and trunk and is often more severe in cold weather.	UMLS:C0263401	hp.json		http://purl.obolibrary.org/obo/HP_0000965		hposlim_core
HP:0000964	biolink:PhenotypicFeature	Eczema	Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding.	MSH:D004485|UMLS:C0013595|SNOMEDCT_US:281104002|SNOMEDCT_US:43116000	hp.json	Eczema	http://purl.obolibrary.org/obo/HP_0000964		
HP:0000967	biolink:PhenotypicFeature	Petechiae	Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae.	MSH:D011693|SNOMEDCT_US:50091001|SNOMEDCT_US:271813007|MEDDRA:10034754|UMLS:C0031256	hp.json		http://purl.obolibrary.org/obo/HP_0000967		hposlim_core
HP:0000966	biolink:PhenotypicFeature	Hypohidrosis	Abnormally diminished capacity to sweat.	MSH:D007007|SNOMEDCT_US:45004005|MEDDRA:10021013|UMLS:C0020620	hp.json	Sweating, decreased|Inadequate sweating|Decreased ability to sweat|Oligohidrosis|Decreased sweating	http://purl.obolibrary.org/obo/HP_0000966		hposlim_core
HP:0000969	biolink:PhenotypicFeature	Edema	An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.	SNOMEDCT_US:423666004|MSH:D004487|SNOMEDCT_US:20741006|SNOMEDCT_US:79654002|UMLS:C0013604|SNOMEDCT_US:267038008	hp.json	Dropsy|Fluid retention|Water retention|Oedema|Hydrops	http://purl.obolibrary.org/obo/HP_0000969		
HP:0000968	biolink:PhenotypicFeature	Ectodermal dysplasia	Ectodermal dysplasia is a group of conditions in which there is abnormal development of the skin, hair, nails, teeth, or sweat glands.	MSH:D004476|UMLS:C0013575|SNOMEDCT_US:8654005|SNOMEDCT_US:254154003	hp.json		http://purl.obolibrary.org/obo/HP_0000968		
HP:0000961	biolink:PhenotypicFeature	Cyanosis	Bluish discoloration of the skin and mucosa due to poor circulation or inadequate oxygenation of arterial or capillary blood.	SNOMEDCT_US:3415004|SNOMEDCT_US:119419001|MSH:D003490|UMLS:C0010520	hp.json	Blue discoloration of the skin	http://purl.obolibrary.org/obo/HP_0000961		
HP:0000960	biolink:PhenotypicFeature	Sacral dimple	A cutaneous indentation resulting from tethering of the skin to underlying structures (bone) of the intergluteal cleft.	SNOMEDCT_US:249729002|UMLS:C0426848|SNOMEDCT_US:311897005	hp.json	Spinal dimple|Pilonidal dimple	http://purl.obolibrary.org/obo/HP_0000960		hposlim_core
HP:0000963	biolink:PhenotypicFeature	Thin skin	Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin.	SNOMEDCT_US:277797007|UMLS:C0423757	hp.json	Thin skin	http://purl.obolibrary.org/obo/HP_0000963		hposlim_core
HP:0000962	biolink:PhenotypicFeature	Hyperkeratosis	Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum.	SNOMEDCT_US:396228006|SNOMEDCT_US:26996000|UMLS:C0870082|MEDDRA:10020649|SNOMEDCT_US:399955009	hp.json		http://purl.obolibrary.org/obo/HP_0000962		hposlim_core
CHEBI:15551	biolink:ChemicalSubstance	prostaglandin E2	Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	PMID:14535055|Patent:GB851827|HMDB:HMDB0001220|PMID:34071686|LINCS:LSM-42919|PMID:16405508|Patent:NL6505799|PMID:9276764|DrugBank:DB00917|PMID:16787416|PMID:33715333|Drug_Central:913|PMID:14703707|FooDB:FDB022498|PMID:2403792|PMID:12746806|PMID:15661432|PMID:32898608|PMID:74611|PMID:33811074|PMID:33958485|PMID:33685091|KEGG:D00079|KEGG:C00584|PMID:6317292|Reaxys:2224724|Beilstein:2224724|PDBeChem:P2E|PMID:33559528|PMID:33271839|CAS:363-24-6|PMID:16978535|PMID:11279302|PMID:33782420|CAS:363-24-6|Patent:DE2011969|Wikipedia:Prostaglandin_E2|PMID:20671299|PMID:15542928|Patent:US3598858|PMID:34065827|PMID:14499495|PMID:7836930|PMID:24501112|PMID:12859290|LIPID_MAPS_instance:LMFA03010003|PMID:34102274|PMID:7224729	hp.json	Prepidil|Prostin E2|Minprostin E2|(E,Z)-(1R,2R,3R)-7-(3-Hydroxy-2-((3S)-(3-hydroxy-1-octenyl))-5-oxocyclopentyl)-5-heptenoic acid|Propess|Cerviprime|Cerviprost|U-12,062|Glandin-E2|Dinoproston|PGE2|(5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprosta-5,13-dienoate|Cervidil|PGE2|Minprositin E2|(Z)-7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid|(15S)-prostaglandin E2|U-12062|dinoprostonum|dinoprostone|Prostin|Enzaprost E|Prostarmon E|(5Z,13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate|(5Z,13E,15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid|Prostaglandin E2|U 12062|dinoprostona|Prostenone|(5Z,11alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid	http://purl.obolibrary.org/obo/CHEBI_15551		3_STAR
HP:0000939	biolink:PhenotypicFeature	Osteoporosis	Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD).	MSH:D010024|SNOMEDCT_US:64859006|UMLS:C0029456	hp.json		http://purl.obolibrary.org/obo/HP_0000939		
GO:0098588	biolink:CellularComponent	bounding membrane of organelle	The lipid bilayer that forms the outer-most layer of an organelle.		hp.json		http://purl.obolibrary.org/obo/GO_0098588		
HP:0000932	biolink:PhenotypicFeature	Abnormal posterior cranial fossa morphology	An abnormality of the fossa cranii posterior (the posterior fossa), which is made up primarily of the occipital bone and which surrounds to the foramen magnum.	UMLS:C3280768	hp.json	Abnormality of the posterior cranial fossa|Posterior fossa anomaly|Abnormality of the posterior fossa	http://purl.obolibrary.org/obo/HP_0000932		
HP:0000931	biolink:PhenotypicFeature	Thinning and bulging of the posterior fossa bones		UMLS:C4021788|UMLS:C4280608	hp.json	Thinning and bulging of occipital bone of skull|Thinning and bulging of posterior fossa bones|Thinning and bulging of posterior skull bones	http://purl.obolibrary.org/obo/HP_0000931		
HP:0000934	biolink:PhenotypicFeature	Chondrocalcinosis	Radiographic evidence of articular calcification that represent calcium pyrophosphate depositions in soft tissue surrounding joints and at the insertions of tendons near joints (Entheses/Sharpey fibers) .	SNOMEDCT_US:239832006|SNOMEDCT_US:239838005|UMLS:C0553730|MSH:D002805|SNOMEDCT_US:201637001	hp.json	Calcium deposits in joints	http://purl.obolibrary.org/obo/HP_0000934		
HP:0000933	biolink:PhenotypicFeature	Posterior fossa cyst at the fourth ventricle		UMLS:C4025816	hp.json		http://purl.obolibrary.org/obo/HP_0000933		
HP:0000935	biolink:PhenotypicFeature	Thickened cortex of long bones	Abnormal thickening of the cortex of long bones.	UMLS:C1840418	hp.json	Broad cortex of long bones|Cortical thickening of the long bones|Thickened cortices of long bones	http://purl.obolibrary.org/obo/HP_0000935		
HP:0000938	biolink:PhenotypicFeature	Osteopenia	Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5.	UMLS:C0747078|MSH:D001851|SNOMEDCT_US:312894000|SNOMEDCT_US:78441005|UMLS:C0029453	hp.json	Generalized osteopenia|Osteopaenia|Generalised osteopenia	http://purl.obolibrary.org/obo/HP_0000938		
HP:0000930	biolink:PhenotypicFeature	Elevated imprint of the transverse sinuses		UMLS:C4025817	hp.json	Thinning and bulging of posterior skull bones over the transverse sinuses|Thinning and bulging of occipital bone over the transverse sinuses|Elevated imprint of occipital bone over the transverse sinuses|Elevated imprint of posterior skull bones over the transverse sinuses	http://purl.obolibrary.org/obo/HP_0000930		
CHEBI:27547	biolink:ChemicalSubstance	zeaxanthin			hp.json		http://purl.obolibrary.org/obo/CHEBI_27547		
GO:0098590	biolink:CellularComponent	plasma membrane region	A membrane that is a (regional) part of the plasma membrane.		hp.json	region of plasma membrane	http://purl.obolibrary.org/obo/GO_0098590		gocheck_do_not_manually_annotate
HP:0000943	biolink:PhenotypicFeature	Dysostosis multiplex		UMLS:C0086795|SNOMEDCT_US:254069004|MSH:D008059|SNOMEDCT_US:65327002	hp.json		http://purl.obolibrary.org/obo/HP_0000943		
HP:0000944	biolink:PhenotypicFeature	Abnormal metaphysis morphology	An abnormality of one or more metaphysis, i.e., of the somewhat wider portion of a long bone that is adjacent to the epiphyseal growth plate and grows during childhood.	UMLS:C4025814	hp.json	Abnormality of the wide portion of a long bone	http://purl.obolibrary.org/obo/HP_0000944		
HP:0000947	biolink:PhenotypicFeature	Dumbbell-shaped long bone	An abnormal appearance of the long bones with resemblance to a dumbbell, a short bar with a weight at each end. That is, the long bone is shortened and displays flaring (widening) of the metaphyses.	UMLS:C2749582	hp.json	Dumbbell-shaped long bone|Dumbbell widening of long bone metaphyses	http://purl.obolibrary.org/obo/HP_0000947		
HP:0000946	biolink:PhenotypicFeature	Hypoplastic ilia	Underdevelopment of the ilium.	UMLS:C4280607|UMLS:C1861218	hp.json	Short and small iliac bones|Small iliac bones|Small wings of the pelvic girdle	http://purl.obolibrary.org/obo/HP_0000946		
HP:0000941	biolink:PhenotypicFeature	Short diaphyses		UMLS:C4025815	hp.json	Short shaft of long bone	http://purl.obolibrary.org/obo/HP_0000941		
HP:0000940	biolink:PhenotypicFeature	Abnormal diaphysis morphology	An abnormality of the structure or form of the diaphysis, i.e., of the main or mid-section (shaft) of a long bone.	UMLS:C4021787	hp.json	Abnormality of shaft of long bone of the limbs|Abnormality of the diaphyses|Abnormality involving the diaphyses of the limbs|Anomaly of the limb diaphyses|Anomaly of the limb diaphyses morphology|Abnormal shape of shaft of long bone	http://purl.obolibrary.org/obo/HP_0000940		
CL:0000240	biolink:Cell	stratified squamous epithelial cell			hp.json		http://purl.obolibrary.org/obo/CL_0000240		
CL:0000242	biolink:Cell	Merkel cell	A modified epidermal cell located in the stratum basale. They are found mostly in areas where sensory perception is acute. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber.	FMA:70548	hp.json	Merkel's cell	http://purl.obolibrary.org/obo/CL_0000242		
CL:0000255	biolink:Cell	eukaryotic cell			hp.json		http://purl.obolibrary.org/obo/CL_0000255		
CL:0000257	biolink:Cell	Eumycetozoan cell			hp.json		http://purl.obolibrary.org/obo/CL_0000257		
GO:1904738	biolink:BiologicalProcess	vascular associated smooth muscle cell migration	The orderly movement of a vascular associated smooth muscle cell from one site to another.		hp.json	vascular smooth muscle cell migration	http://purl.obolibrary.org/obo/GO_1904738		
CL:0000226	biolink:Cell	single nucleate cell	A cell with a single nucleus.		hp.json		http://purl.obolibrary.org/obo/CL_0000226		
CL:0000227	biolink:Cell	binucleate cell			hp.json		http://purl.obolibrary.org/obo/CL_0000227		
CL:0000228	biolink:Cell	multinucleate cell	A cell with more than one nucleus.	WBbt:0008074|AEO:0000203	hp.json	syncitium|syncytium|syncytial cell	http://purl.obolibrary.org/obo/CL_0000228		
PR:Q00342	biolink:Protein	receptor-type tyrosine-protein kinase FLT3 (mouse)	A receptor-type tyrosine-protein kinase FLT3 that is encoded in the genome of mouse.	UniProtKB:Q00342	hp.json	tyrosine-protein kinase receptor flk-2 (mouse)|Flk-2|FLT-3 (mouse)|CD135 (mouse)|mFLT3|fetal liver kinase 2 (mouse)|Flt3|fms-like tyrosine kinase 3 (mouse)|Flt-3|FL cytokine receptor (mouse)|FLK-2 (mouse)	http://purl.obolibrary.org/obo/PR_Q00342		
CL:0000221	biolink:Cell	ectodermal cell	A cell of the outer of the three germ layers of the embryo.	FMA:72549	hp.json	ectoderm cell	http://purl.obolibrary.org/obo/CL_0000221		
CL:0000222	biolink:Cell	mesodermal cell	A cell of the middle germ layer of the embryo.	FMA:72554	hp.json	mesoblast|mesoderm cell	http://purl.obolibrary.org/obo/CL_0000222		
CL:0000223	biolink:Cell	endodermal cell	A cell of the inner of the three germ layers of the embryo.	FMA:72555	hp.json	endoderm cell	http://purl.obolibrary.org/obo/CL_0000223		
CL:0000225	biolink:Cell	anucleate cell	A cell that lacks a nucleus.	FMA:68647	hp.json	non-nucleated cell	http://purl.obolibrary.org/obo/CL_0000225		
GO:1904749	biolink:BiologicalProcess	regulation of protein localization to nucleolus	Any process that modulates the frequency, rate or extent of protein localization to nucleolus.		hp.json	regulation of protein localization in nucleolus|regulation of protein localisation to nucleolus|regulation of protein localisation in nucleolus	http://purl.obolibrary.org/obo/GO_1904749		
GO:1904748	biolink:BiologicalProcess	regulation of apoptotic process involved in development	Any process that modulates the frequency, rate or extent of apoptotic process involved in development.		hp.json	regulation of apoptotic cell death involved in anatomical structure development|regulation of commitment to apoptosis involved in development of an anatomical structure|regulation of apoptosis involved in development of an anatomical structure|regulation of activation of apoptosis involved in development of an anatomical structure|regulation of commitment to apoptosis involved in anatomical structure development|regulation of apoptotic programmed cell death involved in development of an anatomical structure|regulation of apoptosis involved in anatomical structure development|regulation of programmed cell death by apoptosis involved in development of an anatomical structure|regulation of activation of apoptosis involved in anatomical structure development|regulation of apoptotic process involved in development of an anatomical structure|regulation of apoptotic program involved in development of an anatomical structure|regulation of type I programmed cell death involved in development of an anatomical structure|regulation of induction of apoptosis by p53 involved in development of an anatomical structure|regulation of induction of apoptosis involved in development of an anatomical structure|regulation of apoptosis activator activity involved in development of an anatomical structure|regulation of apoptotic programmed cell death involved in anatomical structure development|regulation of programmed cell death by apoptosis involved in anatomical structure development|regulation of induction of apoptosis by p53 involved in anatomical structure development|regulation of apoptotic program involved in anatomical structure development|regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|regulation of apoptotic process involved in anatomical structure development|regulation of type I programmed cell death involved in anatomical structure development|regulation of apoptosis activator activity involved in anatomical structure development|regulation of induction of apoptosis involved in anatomical structure development|regulation of apoptosis signaling involved in development of an anatomical structure|regulation of apoptotic cell death involved in development of an anatomical structure|regulation of signaling (initiator) caspase activity involved in anatomical structure development|regulation of apoptosis signaling involved in anatomical structure development	http://purl.obolibrary.org/obo/GO_1904748		
GO:1904747	biolink:BiologicalProcess	positive regulation of apoptotic process involved in development	Any process that activates or increases the frequency, rate or extent of apoptotic process involved in development.		hp.json	up regulation of apoptotic process involved in development of an anatomical structure|activation of type I programmed cell death involved in development of an anatomical structure|positive regulation of induction of apoptosis involved in anatomical structure development|upregulation of induction of apoptosis involved in development of an anatomical structure|upregulation of apoptosis activator activity involved in development of an anatomical structure|positive regulation of apoptosis activator activity involved in anatomical structure development|upregulation of apoptotic process involved in development|activation of apoptosis signaling involved in anatomical structure development|up regulation of signaling (initiator) caspase activity involved in anatomical structure development|positive regulation of apoptotic programmed cell death involved in anatomical structure development|positive regulation of apoptotic program involved in anatomical structure development|activation of induction of apoptosis involved in development of an anatomical structure|up-regulation of commitment to apoptosis involved in anatomical structure development|activation of apoptosis activator activity involved in development of an anatomical structure|positive regulation of induction of apoptosis by p53 involved in anatomical structure development|up-regulation of apoptosis involved in anatomical structure development|up regulation of apoptotic cell death involved in development of an anatomical structure|positive regulation of apoptotic process involved in anatomical structure development|positive regulation of apoptosis signaling involved in development of an anatomical structure|up-regulation of induction of apoptosis by p53 involved in development of an anatomical structure|upregulation of apoptosis signaling involved in anatomical structure development|activation of apoptotic cell death involved in development of an anatomical structure|up-regulation of apoptotic programmed cell death involved in development of an anatomical structure|up-regulation of activation of apoptosis involved in anatomical structure development|up-regulation of apoptotic cell death involved in anatomical structure development|up-regulation of apoptotic program involved in development of an anatomical structure|activation of apoptotic programmed cell death involved in development of an anatomical structure|positive regulation of signaling (initiator) caspase activity involved in anatomical structure development|upregulation of programmed cell death by apoptosis involved in anatomical structure development|up regulation of apoptotic program involved in anatomical structure development|positive regulation of apoptotic cell death involved in development of an anatomical structure|up regulation of apoptotic programmed cell death involved in anatomical structure development|activation of apoptosis involved in development of an anatomical structure|activation of apoptotic process involved in development of an anatomical structure|up-regulation of apoptotic process involved in development of an anatomical structure|up regulation of induction of apoptosis by p53 involved in anatomical structure development|upregulation of signaling (initiator) caspase activity involved in development of an anatomical structure|activation of commitment to apoptosis involved in development of an anatomical structure|upregulation of type I programmed cell death involved in anatomical structure development|upregulation of commitment to apoptosis involved in development of an anatomical structure|activation of type I programmed cell death involved in anatomical structure development|upregulation of apoptosis activator activity involved in anatomical structure development|up regulation of apoptotic process involved in anatomical structure development|activation of activation of apoptosis involved in development of an anatomical structure|activation of signaling (initiator) caspase activity involved in development of an anatomical structure|upregulation of induction of apoptosis involved in anatomical structure development|upregulation of apoptosis involved in development of an anatomical structure|up regulation of apoptosis signaling involved in development of an anatomical structure|upregulation of activation of apoptosis involved in development of an anatomical structure|activation of induction of apoptosis involved in anatomical structure development|up regulation of apoptotic cell death involved in anatomical structure development|activation of apoptosis activator activity involved in anatomical structure development|up-regulation of apoptotic program involved in anatomical structure development|up-regulation of programmed cell death by apoptosis involved in development of an anatomical structure|up-regulation of type I programmed cell death involved in development of an anatomical structure|activation of apoptotic cell death involved in anatomical structure development|up-regulation of induction of apoptosis by p53 involved in anatomical structure development|up-regulation of apoptotic programmed cell death involved in anatomical structure development|activation of apoptotic programmed cell death involved in anatomical structure development|positive regulation of apoptosis signaling involved in anatomical structure development|activation of apoptotic process involved in anatomical structure development|up-regulation of apoptosis signaling involved in development of an anatomical structure|positive regulation of apoptotic cell death involved in anatomical structure development|activation of commitment to apoptosis involved in anatomical structure development|up-regulation of apoptosis activator activity involved in development of an anatomical structure|up-regulation of apoptotic process involved in development|up-regulation of apoptotic process involved in anatomical structure development|upregulation of signaling (initiator) caspase activity involved in anatomical structure development|upregulation of apoptotic cell death involved in development of an anatomical structure|activation of apoptosis involved in anatomical structure development|up-regulation of induction of apoptosis involved in development of an anatomical structure|positive regulation of commitment to apoptosis involved in development of an anatomical structure|activation of apoptotic program involved in development of an anatomical structure|upregulation of commitment to apoptosis involved in anatomical structure development|activation of induction of apoptosis by p53 involved in development of an anatomical structure|activation of signaling (initiator) caspase activity involved in anatomical structure development|up regulation of apoptosis signaling involved in anatomical structure development|activation of activation of apoptosis involved in anatomical structure development|positive regulation of apoptosis involved in development of an anatomical structure|upregulation of apoptosis involved in anatomical structure development|up regulation of type I programmed cell death involved in development of an anatomical structure|up regulation of programmed cell death by apoptosis involved in development of an anatomical structure|upregulation of apoptotic program involved in development of an anatomical structure|upregulation of apoptotic programmed cell death involved in development of an anatomical structure|positive regulation of activation of apoptosis involved in development of an anatomical structure|upregulation of induction of apoptosis by p53 involved in development of an anatomical structure|upregulation of activation of apoptosis involved in anatomical structure development|up regulation of commitment to apoptosis involved in development of an anatomical structure|up regulation of apoptotic process involved in development|upregulation of apoptotic process involved in development of an anatomical structure|up-regulation of programmed cell death by apoptosis involved in anatomical structure development|up-regulation of type I programmed cell death involved in anatomical structure development|activation of programmed cell death by apoptosis involved in development of an anatomical structure|up regulation of apoptosis involved in development of an anatomical structure|up regulation of apoptosis activator activity involved in development of an anatomical structure|up regulation of induction of apoptosis involved in development of an anatomical structure|up-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|positive regulation of programmed cell death by apoptosis involved in development of an anatomical structure|positive regulation of type I programmed cell death involved in development of an anatomical structure|up-regulation of induction of apoptosis involved in anatomical structure development|up regulation of activation of apoptosis involved in development of an anatomical structure|upregulation of apoptotic cell death involved in anatomical structure development|up-regulation of apoptosis signaling involved in anatomical structure development|activation of apoptotic process involved in development|up-regulation of apoptosis activator activity involved in anatomical structure development|positive regulation of apoptosis involved in anatomical structure development|positive regulation of commitment to apoptosis involved in anatomical structure development|positive regulation of apoptosis activator activity involved in development of an anatomical structure|activation of apoptotic program involved in anatomical structure development|positive regulation of induction of apoptosis involved in development of an anatomical structure|activation of induction of apoptosis by p53 involved in anatomical structure development|up regulation of programmed cell death by apoptosis involved in anatomical structure development|up regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|upregulation of induction of apoptosis by p53 involved in anatomical structure development|up regulation of type I programmed cell death involved in anatomical structure development|positive regulation of apoptotic program involved in development of an anatomical structure|upregulation of apoptotic program involved in anatomical structure development|upregulation of apoptotic programmed cell death involved in anatomical structure development|positive regulation of activation of apoptosis involved in anatomical structure development|activation of apoptosis signaling involved in development of an anatomical structure|positive regulation of induction of apoptosis by p53 involved in development of an anatomical structure|up-regulation of commitment to apoptosis involved in development of an anatomical structure|positive regulation of apoptotic programmed cell death involved in development of an anatomical structure|up-regulation of apoptosis involved in development of an anatomical structure|upregulation of apoptotic process involved in anatomical structure development|upregulation of apoptosis signaling involved in development of an anatomical structure|positive regulation of apoptotic process involved in development of an anatomical structure|up regulation of commitment to apoptosis involved in anatomical structure development|up-regulation of activation of apoptosis involved in development of an anatomical structure|activation of programmed cell death by apoptosis involved in anatomical structure development|up regulation of induction of apoptosis involved in anatomical structure development|up-regulation of signaling (initiator) caspase activity involved in anatomical structure development|up-regulation of apoptotic cell death involved in development of an anatomical structure|up regulation of apoptosis involved in anatomical structure development|up regulation of apoptosis activator activity involved in anatomical structure development|upregulation of type I programmed cell death involved in development of an anatomical structure|up regulation of apoptotic program involved in development of an anatomical structure|up regulation of activation of apoptosis involved in anatomical structure development|positive regulation of type I programmed cell death involved in anatomical structure development|up regulation of induction of apoptosis by p53 involved in development of an anatomical structure|positive regulation of programmed cell death by apoptosis involved in anatomical structure development|up regulation of apoptotic programmed cell death involved in development of an anatomical structure|positive regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|upregulation of programmed cell death by apoptosis involved in development of an anatomical structure	http://purl.obolibrary.org/obo/GO_1904747		
CL:0000237	biolink:Cell	keratinizing barrier epithelial cell			hp.json		http://purl.obolibrary.org/obo/CL_0000237		
GO:1904746	biolink:BiologicalProcess	negative regulation of apoptotic process involved in development	Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in development.		hp.json	negative regulation of induction of apoptosis involved in development of an anatomical structure|inhibition of induction of apoptosis involved in anatomical structure development|down-regulation of induction of apoptosis involved in development of an anatomical structure|negative regulation of apoptosis activator activity involved in development of an anatomical structure|inhibition of apoptosis activator activity involved in anatomical structure development|down-regulation of apoptosis activator activity involved in development of an anatomical structure|inhibition of apoptotic program involved in anatomical structure development|inhibition of apoptotic cell death involved in anatomical structure development|inhibition of induction of apoptosis by p53 involved in anatomical structure development|downregulation of apoptosis involved in anatomical structure development|down regulation of programmed cell death by apoptosis involved in development of an anatomical structure|down regulation of apoptosis involved in development of an anatomical structure|downregulation of apoptotic programmed cell death involved in development of an anatomical structure|down regulation of commitment to apoptosis involved in development of an anatomical structure|downregulation of commitment to apoptosis involved in anatomical structure development|downregulation of apoptotic cell death involved in anatomical structure development|negative regulation of programmed cell death by apoptosis involved in anatomical structure development|down regulation of activation of apoptosis involved in development of an anatomical structure|down regulation of apoptotic process involved in development|downregulation of induction of apoptosis by p53 involved in development of an anatomical structure|down-regulation of programmed cell death by apoptosis involved in anatomical structure development|downregulation of apoptotic process involved in development of an anatomical structure|inhibition of apoptosis signaling involved in development of an anatomical structure|downregulation of activation of apoptosis involved in anatomical structure development|down regulation of type I programmed cell death involved in development of an anatomical structure|down-regulation of apoptosis signaling involved in anatomical structure development|negative regulation of apoptosis signaling involved in anatomical structure development|downregulation of apoptotic program involved in development of an anatomical structure|inhibition of signaling (initiator) caspase activity involved in anatomical structure development|negative regulation of type I programmed cell death involved in anatomical structure development|down regulation of induction of apoptosis involved in development of an anatomical structure|down regulation of apoptosis activator activity involved in development of an anatomical structure|down-regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|negative regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|down-regulation of type I programmed cell death involved in anatomical structure development|down-regulation of apoptosis activator activity involved in anatomical structure development|negative regulation of commitment to apoptosis involved in development of an anatomical structure|negative regulation of induction of apoptosis involved in anatomical structure development|down-regulation of apoptosis involved in development of an anatomical structure|down-regulation of induction of apoptosis involved in anatomical structure development|negative regulation of apoptosis involved in development of an anatomical structure|down-regulation of commitment to apoptosis involved in development of an anatomical structure|negative regulation of apoptosis activator activity involved in anatomical structure development|downregulation of apoptotic programmed cell death involved in anatomical structure development|down regulation of commitment to apoptosis involved in anatomical structure development|down regulation of programmed cell death by apoptosis involved in anatomical structure development|inhibition of programmed cell death by apoptosis involved in development of an anatomical structure|down-regulation of activation of apoptosis involved in development of an anatomical structure|negative regulation of activation of apoptosis involved in development of an anatomical structure|down regulation of apoptotic programmed cell death involved in development of an anatomical structure|down regulation of apoptosis involved in anatomical structure development|downregulation of programmed cell death by apoptosis involved in development of an anatomical structure|down regulation of activation of apoptosis involved in anatomical structure development|down regulation of signaling (initiator) caspase activity involved in development of an anatomical structure|down-regulation of apoptotic cell death involved in development of an anatomical structure|downregulation of apoptotic process involved in anatomical structure development|downregulation of apoptotic program involved in anatomical structure development|downregulation of type I programmed cell death involved in development of an anatomical structure|down regulation of induction of apoptosis by p53 involved in development of an anatomical structure|inhibition of apoptosis signaling involved in anatomical structure development|downregulation of apoptotic process involved in development|down regulation of apoptotic process involved in development of an anatomical structure|negative regulation of apoptotic cell death involved in development of an anatomical structure|inhibition of apoptotic process involved in development|down regulation of type I programmed cell death involved in anatomical structure development|down regulation of apoptotic program involved in development of an anatomical structure|downregulation of induction of apoptosis by p53 involved in anatomical structure development|down regulation of apoptosis activator activity involved in anatomical structure development|downregulation of apoptosis signaling involved in development of an anatomical structure|down-regulation of signaling (initiator) caspase activity involved in anatomical structure development|downregulation of apoptosis activator activity involved in development of an anatomical structure|downregulation of induction of apoptosis involved in development of an anatomical structure|down regulation of induction of apoptosis involved in anatomical structure development|negative regulation of signaling (initiator) caspase activity involved in anatomical structure development|inhibition of apoptotic programmed cell death involved in development of an anatomical structure|down-regulation of apoptotic programmed cell death involved in development of an anatomical structure|inhibition of apoptosis involved in development of an anatomical structure|inhibition of commitment to apoptosis involved in development of an anatomical structure|negative regulation of commitment to apoptosis involved in anatomical structure development|negative regulation of apoptotic programmed cell death involved in development of an anatomical structure|inhibition of apoptotic process involved in development of an anatomical structure|down-regulation of apoptosis involved in anatomical structure development|negative regulation of apoptosis involved in anatomical structure development|down-regulation of commitment to apoptosis involved in anatomical structure development|downregulation of programmed cell death by apoptosis involved in anatomical structure development|down regulation of apoptotic cell death involved in development of an anatomical structure|negative regulation of induction of apoptosis by p53 involved in development of an anatomical structure|down-regulation of apoptotic program involved in development of an anatomical structure|inhibition of programmed cell death by apoptosis involved in anatomical structure development|down-regulation of apoptotic process involved in development of an anatomical structure|down-regulation of activation of apoptosis involved in anatomical structure development|inhibition of activation of apoptosis involved in development of an anatomical structure|down regulation of apoptotic programmed cell death involved in anatomical structure development|down-regulation of induction of apoptosis by p53 involved in development of an anatomical structure|negative regulation of apoptotic program involved in development of an anatomical structure|negative regulation of apoptotic process involved in development of an anatomical structure|negative regulation of activation of apoptosis involved in anatomical structure development|downregulation of signaling (initiator) caspase activity involved in development of an anatomical structure|down regulation of signaling (initiator) caspase activity involved in anatomical structure development|negative regulation of apoptotic cell death involved in anatomical structure development|down regulation of apoptotic program involved in anatomical structure development|down regulation of apoptotic process involved in anatomical structure development|downregulation of type I programmed cell death involved in anatomical structure development|down-regulation of apoptotic cell death involved in anatomical structure development|down regulation of induction of apoptosis by p53 involved in anatomical structure development|down regulation of apoptosis signaling involved in development of an anatomical structure|inhibition of type I programmed cell death involved in development of an anatomical structure|downregulation of induction of apoptosis involved in anatomical structure development|downregulation of apoptosis activator activity involved in anatomical structure development|downregulation of apoptosis signaling involved in anatomical structure development|inhibition of apoptotic programmed cell death involved in anatomical structure development|negative regulation of apoptotic programmed cell death involved in anatomical structure development|inhibition of commitment to apoptosis involved in anatomical structure development|inhibition of apoptotic process involved in anatomical structure development|inhibition of apoptosis activator activity involved in development of an anatomical structure|inhibition of induction of apoptosis involved in development of an anatomical structure|down-regulation of apoptotic programmed cell death involved in anatomical structure development|inhibition of apoptosis involved in anatomical structure development|down-regulation of apoptotic process involved in anatomical structure development|down-regulation of induction of apoptosis by p53 involved in anatomical structure development|inhibition of induction of apoptosis by p53 involved in development of an anatomical structure|inhibition of activation of apoptosis involved in anatomical structure development|down regulation of apoptotic cell death involved in anatomical structure development|downregulation of apoptotic cell death involved in development of an anatomical structure|negative regulation of apoptotic program involved in anatomical structure development|downregulation of apoptosis involved in development of an anatomical structure|down-regulation of apoptotic program involved in anatomical structure development|inhibition of apoptotic program involved in development of an anatomical structure|negative regulation of apoptotic process involved in anatomical structure development|negative regulation of induction of apoptosis by p53 involved in anatomical structure development|inhibition of apoptotic cell death involved in development of an anatomical structure|downregulation of commitment to apoptosis involved in development of an anatomical structure|downregulation of activation of apoptosis involved in development of an anatomical structure|negative regulation of programmed cell death by apoptosis involved in development of an anatomical structure|down-regulation of programmed cell death by apoptosis involved in development of an anatomical structure|negative regulation of apoptosis signaling involved in development of an anatomical structure|downregulation of signaling (initiator) caspase activity involved in anatomical structure development|down-regulation of apoptosis signaling involved in development of an anatomical structure|down-regulation of type I programmed cell death involved in development of an anatomical structure|inhibition of signaling (initiator) caspase activity involved in development of an anatomical structure|down-regulation of apoptotic process involved in development|negative regulation of type I programmed cell death involved in development of an anatomical structure|inhibition of type I programmed cell death involved in anatomical structure development|down regulation of apoptosis signaling involved in anatomical structure development	http://purl.obolibrary.org/obo/GO_1904746		
GO:1904750	biolink:BiologicalProcess	negative regulation of protein localization to nucleolus	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus.		hp.json	down-regulation of protein localization to nucleolus|down regulation of protein localisation in nucleolus|down regulation of protein localization to nucleolus|inhibition of protein localisation in nucleolus|downregulation of protein localisation in nucleolus|down-regulation of protein localization in nucleolus|inhibition of protein localization to nucleolus|negative regulation of protein localization in nucleolus|downregulation of protein localization to nucleolus|down-regulation of protein localisation to nucleolus|negative regulation of protein localisation to nucleolus|down regulation of protein localization in nucleolus|down regulation of protein localisation to nucleolus|inhibition of protein localization in nucleolus|downregulation of protein localization in nucleolus|down-regulation of protein localisation in nucleolus|inhibition of protein localisation to nucleolus|negative regulation of protein localisation in nucleolus|downregulation of protein localisation to nucleolus	http://purl.obolibrary.org/obo/GO_1904750		
CL:0000232	biolink:Cell	erythrocyte	A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.	FMA:81100|CALOHA:TS-0290|BTO:0000424	hp.json	red blood cell|RBC	http://purl.obolibrary.org/obo/CL_0000232		
CL:0000233	biolink:Cell	platelet	A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.	CALOHA:TS-0803|FMA:62851|BTO:0000132	hp.json	enucleate thrombocyte|anucleate thrombocyte|blood platelet	http://purl.obolibrary.org/obo/CL_0000233		
CL:0000234	biolink:Cell	phagocyte	Any cell capable of ingesting particulate matter via phagocytosis.	FMA:83806|BTO:0001044	hp.json		http://purl.obolibrary.org/obo/CL_0000234		
CL:0000235	biolink:Cell	macrophage	A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.	FMA:83585|CALOHA:TS-0587|FMA:63261|BTO:0000801	hp.json	histiocyte	http://purl.obolibrary.org/obo/CL_0000235		
CL:0000236	biolink:Cell	B cell	A lymphocyte of B lineage that is capable of B cell mediated immunity.	BTO:0000776|CALOHA:TS-0068|FMA:62869|VHOG:0001480	hp.json	B-lymphocyte|B-cell|B lymphocyte	http://purl.obolibrary.org/obo/CL_0000236		
HP:0034294	biolink:PhenotypicFeature	Ductal bile plugs	Bile thrombi that form an obstruction (plug) in a dilated bile duct.		hp.json		http://purl.obolibrary.org/obo/HP_0034294		
HP:0034293	biolink:PhenotypicFeature	Temporal lobe calcification	The presence of calcium deposition within the temporal lobe of the brain.		hp.json		http://purl.obolibrary.org/obo/HP_0034293		
GO:0001578	biolink:BiologicalProcess	microtubule bundle formation	A process that results in a parallel arrangement of microtubules.		hp.json	microtubule bundling	http://purl.obolibrary.org/obo/GO_0001578		
HP:0034296	biolink:PhenotypicFeature	Elevated urine 3,5,6-trichloro-2-pyridinol level	Detection of 3,5,6-trichloro-2-pyridinol in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0034296		
HP:0034295	biolink:PhenotypicFeature	Reduced cerebral white matter volume	An abnormally low volume of the white matter of the brain.		hp.json	White matter loss	http://purl.obolibrary.org/obo/HP_0034295		
HP:0034290	biolink:PhenotypicFeature	Elevated circulating tiglylglycine concentration	An increased concentration of tiglylglycine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034290		
GO:0001573	biolink:BiologicalProcess	ganglioside metabolic process	The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.		hp.json	ganglioside metabolism	http://purl.obolibrary.org/obo/GO_0001573		
HP:0034292	biolink:PhenotypicFeature	Reduced circulating creatine concentration	An reduction below the normal range of creatine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034292		
HP:0034291	biolink:PhenotypicFeature	Elevated circulating creatine concentration	An elevation above the normal range of creatine in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034291		
CL:0000206	biolink:Cell	chemoreceptor cell	A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood.		hp.json		http://purl.obolibrary.org/obo/CL_0000206		
GO:0001570	biolink:BiologicalProcess	vasculogenesis	The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.	Wikipedia:Vasculogenesis	hp.json	vascular morphogenesis	http://purl.obolibrary.org/obo/GO_0001570		
CL:0000207	biolink:Cell	olfactory receptor cell		BTO:0004185|FMA:67860	hp.json	olfactory sensory neuron|Schultze's cell|odorant receptor cell|olfactory receptor neuron	http://purl.obolibrary.org/obo/CL_0000207		
GO:1904754	biolink:BiologicalProcess	positive regulation of vascular associated smooth muscle cell migration	Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell migration.		hp.json	upregulation of vascular associated smooth muscle cell migration|up-regulation of vascular smooth muscle cell migration|up regulation of vascular smooth muscle cell migration|up regulation of vascular associated smooth muscle cell migration|activation of vascular smooth muscle cell migration|positive regulation of vascular smooth muscle cell migration|up-regulation of vascular associated smooth muscle cell migration|activation of vascular associated smooth muscle cell migration|upregulation of vascular smooth muscle cell migration	http://purl.obolibrary.org/obo/GO_1904754		
HP:0034298	biolink:PhenotypicFeature	Elevated circulating hexacosanoic acid concentration	Elevated concentration of hexacosanoic acid (a C26 straight-chain saturated fatty acid) in the blood circulation.		hp.json	Elevated circulating cerotic acid concentration	http://purl.obolibrary.org/obo/HP_0034298		
GO:1904753	biolink:BiologicalProcess	negative regulation of vascular associated smooth muscle cell migration	Any process that stops, prevents or reduces the frequency, rate or extent of vascular associated smooth muscle cell migration.		hp.json	inhibition of vascular associated smooth muscle cell migration|down regulation of vascular smooth muscle cell migration|down-regulation of vascular associated smooth muscle cell migration|inhibition of vascular smooth muscle cell migration|downregulation of vascular smooth muscle cell migration|downregulation of vascular associated smooth muscle cell migration|negative regulation of vascular smooth muscle cell migration|down-regulation of vascular smooth muscle cell migration|down regulation of vascular associated smooth muscle cell migration	http://purl.obolibrary.org/obo/GO_1904753		
CL:0000209	biolink:Cell	taste receptor cell	A cell type found in the spherical or ovoid clusters of receptor cells found mainly in the epithelium of the tongue and constituting the end organs of the sense of taste.	FMA:67910	hp.json	taste bud cell	http://purl.obolibrary.org/obo/CL_0000209		
HP:0034297	biolink:PhenotypicFeature	Elevated circulating tetracosanoic acid concentration	Elevated concentration of tetracosanoic acid (a C24 straight-chain saturated fatty acid) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034297		
GO:1904752	biolink:BiologicalProcess	regulation of vascular associated smooth muscle cell migration	Any process that modulates the frequency, rate or extent of vascular associated smooth muscle cell migration.		hp.json	regulation of vascular smooth muscle cell migration	http://purl.obolibrary.org/obo/GO_1904752		
GO:1904751	biolink:BiologicalProcess	positive regulation of protein localization to nucleolus	Any process that activates or increases the frequency, rate or extent of protein localization to nucleolus.		hp.json	up regulation of protein localization in nucleolus|upregulation of protein localization to nucleolus|up regulation of protein localisation to nucleolus|positive regulation of protein localization in nucleolus|activation of protein localization in nucleolus|positive regulation of protein localisation to nucleolus|activation of protein localisation to nucleolus|up-regulation of protein localisation in nucleolus|upregulation of protein localization in nucleolus|up regulation of protein localisation in nucleolus|upregulation of protein localisation to nucleolus|up-regulation of protein localization to nucleolus|activation of protein localisation in nucleolus|positive regulation of protein localisation in nucleolus|up regulation of protein localization to nucleolus|activation of protein localization to nucleolus|upregulation of protein localisation in nucleolus|up-regulation of protein localization in nucleolus|up-regulation of protein localisation to nucleolus	http://purl.obolibrary.org/obo/GO_1904751		
HP:0034299	biolink:PhenotypicFeature	Sertoli cell-only phenotype	A histological phenotype observed on testicular biopsy in which only Sertoli cells line the seminiferous tubules of the testis.		hp.json		http://purl.obolibrary.org/obo/HP_0034299		
GO:0098528	biolink:BiologicalProcess	skeletal muscle fiber differentiation	The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.		hp.json		http://purl.obolibrary.org/obo/GO_0098528		
GO:0098523	biolink:CellularComponent	neuromuscular junction of myotube	A neuromuscular junction in which the target muscle cell is a myotube.		hp.json		http://purl.obolibrary.org/obo/GO_0098523		
GO:1902106	biolink:BiologicalProcess	negative regulation of leukocyte differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.		hp.json	inhibition of leukocyte differentiation|downregulation of leukocyte differentiation|down-regulation of immune cell differentiation|negative regulation of immune cell differentiation|negative regulation of leucocyte differentiation|down-regulation of leucocyte differentiation|down regulation of leucocyte differentiation|down regulation of immune cell differentiation|inhibition of leucocyte differentiation|downregulation of leucocyte differentiation|downregulation of immune cell differentiation|inhibition of immune cell differentiation|down-regulation of leukocyte differentiation|down regulation of leukocyte differentiation	http://purl.obolibrary.org/obo/GO_1902106		
CL:0000215	biolink:Cell	barrier cell	A cell whose primary function is to prevent the transport of stuff across compartments.		hp.json		http://purl.obolibrary.org/obo/CL_0000215		
GO:1902107	biolink:BiologicalProcess	positive regulation of leukocyte differentiation	Any process that activates or increases the frequency, rate or extent of leukocyte differentiation.		hp.json	activation of leucocyte differentiation|activation of immune cell differentiation|positive regulation of leucocyte differentiation|positive regulation of immune cell differentiation|up-regulation of leukocyte differentiation|upregulation of leucocyte differentiation|upregulation of immune cell differentiation|up regulation of leukocyte differentiation|activation of leukocyte differentiation|up-regulation of immune cell differentiation|up-regulation of leucocyte differentiation|upregulation of leukocyte differentiation|up regulation of immune cell differentiation|up regulation of leucocyte differentiation	http://purl.obolibrary.org/obo/GO_1902107		
CL:0000216	biolink:Cell	Sertoli cell	A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier.	BTO:0001238|CALOHA:TS-0922|FMA:72298|VHOG:0001348	hp.json		http://purl.obolibrary.org/obo/CL_0000216		
CL:0000217	biolink:Cell	insulating cell			hp.json		http://purl.obolibrary.org/obo/CL_0000217		
GO:1902105	biolink:BiologicalProcess	regulation of leukocyte differentiation	Any process that modulates the frequency, rate or extent of leukocyte differentiation.		hp.json	regulation of immune cell differentiation|regulation of leucocyte differentiation	http://purl.obolibrary.org/obo/GO_1902105		
CL:0000218	biolink:Cell	myelinating Schwann cell	A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons.	CALOHA:TS-0898|FMA:62121	hp.json	peripheral neuroglial cell|neurilemmal cell|Schwann cell	http://purl.obolibrary.org/obo/CL_0000218		
CL:0000219	biolink:Cell	motile cell	A cell that moves by its own activities.		hp.json		http://purl.obolibrary.org/obo/CL_0000219		
PR:Q63961	biolink:Protein	endoglin (mouse)	An endoglin that is encoded in the genome of mouse.	UniProtKB:Q63961	hp.json	Edg|cell surface MJ7/18 antigen (mouse)|mENG|CD105 (mouse)|Eng	http://purl.obolibrary.org/obo/PR_Q63961		
GO:1904770	biolink:BiologicalProcess	intramembranous bone morphogenesis	The developmental process by which an intramembranous bone is generated and organized.		hp.json	intramembranous bones morphogenesis|membrane bone morphogenesis	http://purl.obolibrary.org/obo/GO_1904770		
CL:0000210	biolink:Cell	photoreceptor cell	A cell specialized to detect and transduce light.	FBbt:00004211|CALOHA:TS-0868|FMA:86740|BTO:0001060	hp.json		http://purl.obolibrary.org/obo/CL_0000210		
CL:0000211	biolink:Cell	electrically active cell	A cell whose function is determined by the generation or the reception of an electric signal.		hp.json		http://purl.obolibrary.org/obo/CL_0000211		
CL:0000213	biolink:Cell	lining cell	A cell within an epithelial cell sheet whose main function is to act as an internal or external covering for a tissue or an organism.		hp.json	boundary cell	http://purl.obolibrary.org/obo/CL_0000213		
CL:0000214	biolink:Cell	synovial cell	A cell located in the synovial joint.	CALOHA:TS-0995	hp.json	synoviocyte	http://purl.obolibrary.org/obo/CL_0000214		
GO:0001555	biolink:BiologicalProcess	oocyte growth	The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.		hp.json		http://purl.obolibrary.org/obo/GO_0001555		
GO:0001556	biolink:BiologicalProcess	oocyte maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.	Wikipedia:Oocyte_maturation	hp.json		http://purl.obolibrary.org/obo/GO_0001556		
GO:0001553	biolink:BiologicalProcess	luteinization	The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.	Wikipedia:Luteal_phase|Wikipedia:Luteinization	hp.json	luteal phase	http://purl.obolibrary.org/obo/GO_0001553		
GO:1902117	biolink:BiologicalProcess	positive regulation of organelle assembly	Any process that activates or increases the frequency, rate or extent of organelle assembly.		hp.json	upregulation of organelle assembly|up regulation of organelle assembly|activation of organelle assembly|up-regulation of organelle assembly	http://purl.obolibrary.org/obo/GO_1902117		
GO:1904778	biolink:BiologicalProcess	positive regulation of protein localization to cell cortex	Any process that activates or increases the frequency, rate or extent of protein localization to cell cortex.		hp.json	upregulation of protein localization to cell cortex|up regulation of protein localisation to cell cortex|activation of protein localisation to cell cortex|positive regulation of protein localisation to cell cortex|up-regulation of protein localization to cell cortex|upregulation of protein localisation to cell cortex|up regulation of protein localization to cell cortex|activation of protein localization to cell cortex|up-regulation of protein localisation to cell cortex	http://purl.obolibrary.org/obo/GO_1904778		
GO:1902115	biolink:BiologicalProcess	regulation of organelle assembly	Any process that modulates the frequency, rate or extent of organelle assembly.		hp.json		http://purl.obolibrary.org/obo/GO_1902115		
GO:1904777	biolink:BiologicalProcess	negative regulation of protein localization to cell cortex	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell cortex.		hp.json	down-regulation of protein localization to cell cortex|down regulation of protein localization to cell cortex|inhibition of protein localization to cell cortex|down-regulation of protein localisation to cell cortex|downregulation of protein localization to cell cortex|negative regulation of protein localisation to cell cortex|down regulation of protein localisation to cell cortex|downregulation of protein localisation to cell cortex|inhibition of protein localisation to cell cortex	http://purl.obolibrary.org/obo/GO_1904777		
GO:1902116	biolink:BiologicalProcess	negative regulation of organelle assembly	Any process that stops, prevents or reduces the frequency, rate or extent of organelle assembly.		hp.json	down regulation of organelle assembly|inhibition of organelle assembly|down-regulation of organelle assembly|downregulation of organelle assembly	http://purl.obolibrary.org/obo/GO_1902116		
GO:1904776	biolink:BiologicalProcess	regulation of protein localization to cell cortex	Any process that modulates the frequency, rate or extent of protein localization to cell cortex.		hp.json	regulation of protein localisation to cell cortex	http://purl.obolibrary.org/obo/GO_1904776		
GO:1902113	biolink:BiologicalProcess	nucleotide phosphorylation involved in DNA repair	Any nucleotide phosphorylation that is involved in DNA repair.		hp.json		http://purl.obolibrary.org/obo/GO_1902113		
PR:Q63994	biolink:Protein	myeloid cell surface antigen CD33 (mouse)	A CD33 molecule that is encoded in the genome of mouse.	UniProtKB:Q63994	hp.json	Cd33|mCD33|sialic acid-binding Ig-like lectin 3 (mouse)|CD33 (mouse)|Siglec3|siglec-3 (mouse)	http://purl.obolibrary.org/obo/PR_Q63994		
GO:0001558	biolink:BiologicalProcess	regulation of cell growth	Any process that modulates the frequency, rate, extent or direction of cell growth.		hp.json		http://purl.obolibrary.org/obo/GO_0001558		
GO:0001568	biolink:BiologicalProcess	blood vessel development	The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.		hp.json		http://purl.obolibrary.org/obo/GO_0001568		
GO:1904794	biolink:BiologicalProcess	negative regulation of euchromatin binding	Any process that stops, prevents or reduces the frequency, rate or extent of euchromatin binding.		hp.json	down-regulation of euchromatin binding|down regulation of euchromatin binding|inhibition of euchromatin binding|downregulation of euchromatin binding	http://purl.obolibrary.org/obo/GO_1904794		
GO:1904793	biolink:BiologicalProcess	regulation of euchromatin binding	Any process that modulates the frequency, rate or extent of euchromatin binding.		hp.json		http://purl.obolibrary.org/obo/GO_1904793		
GO:0001569	biolink:BiologicalProcess	branching involved in blood vessel morphogenesis	The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.		hp.json	patterning of blood vessels	http://purl.obolibrary.org/obo/GO_0001569		
HP:4000049	biolink:PhenotypicFeature	Segmental fracture	A type of fracture in which the same bone is fractured in two places, so there is a floating segment of bone.		hp.json		http://purl.obolibrary.org/obo/HP_4000049		
HP:0009294	biolink:PhenotypicFeature	Absent middle phalanx of 4th finger	Absence of the middle phalanx of the ring (4th) finger.	UMLS:C4021498	hp.json	Absent middle bone of 4th finger|Aplasia of the middle phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009294		
HP:0034250	biolink:PhenotypicFeature	Fetal nuchal edema	Nuchal edema is considered present in a fetus at gestational week 14 or more if in the midsagittal plane of the neck, there is subcutaneous edema that produces a characteristic tremor on ballotment of the fetal head. This constitutes the severe end of the spectrum of increased nuchal fold thickness, which is defined as soft-tissue thickening of 6 mm or more, seen in the suboccipitobregmatic view of the fetal head. Nuchal edema may be confined to the neck or it may be generalized, as part of hydrops fetalis.		hp.json		http://purl.obolibrary.org/obo/HP_0034250		
HP:0009293	biolink:PhenotypicFeature	Broad middle phalanx of the 4th finger	Increased width of the middle phalanx of the 4th finger.	UMLS:C4024463	hp.json	Broad middle bone of the 4th finger	http://purl.obolibrary.org/obo/HP_0009293		
HP:0010282	biolink:PhenotypicFeature	Thin lower lip vermilion	Height of the vermilion of the medial part of the lower lip more than 2 SD below the mean. Alternatively, an apparently reduced height of the vermilion of the lower lip in the frontal view (subjective).	UMLS:C2053440	hp.json	Thin lower lip|Thin red part of the lower lip|Decreased height of lower lip vermilion|Decreased volume of lower lip|Thin vermilion border of lower lip|Decreased volume of lower lip vermilion	http://purl.obolibrary.org/obo/HP_0010282		
HP:0010281	biolink:PhenotypicFeature	Cleft lower lip	A gap in the lower lip.	UMLS:C1856026	hp.json	Cleft lower lip|Lower labial cleft|Cleft of the lower lip	http://purl.obolibrary.org/obo/HP_0010281		hposlim_core
HP:4000047	biolink:PhenotypicFeature	Compression fracture	A type of fracture in which the bone is crushed, causing the broken bone to be wider or flatter in appearance.		hp.json	Wedge fracture	http://purl.obolibrary.org/obo/HP_4000047		
HP:0009296	biolink:PhenotypicFeature	Bullet-shaped middle phalanx of the 4th finger	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally . Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the middle phalanx of the 4th finger is affected.	UMLS:C4024462	hp.json	Bullet-shaped middle bone of the 4th finger	http://purl.obolibrary.org/obo/HP_0009296		
HP:0034252	biolink:PhenotypicFeature	Absent corneal reflex	Absence of the corneal blinking reflex, which normally induces involuntary blinking of the eyelids following contact of the cornea. The corneal blink reflex is caused by a loop between the trigeminal sensory nerves and the facial motor (VII) nerve innervation of the orbicularis oculi muscles.		hp.json		http://purl.obolibrary.org/obo/HP_0034252		
HP:4000048	biolink:PhenotypicFeature	Comminuted fracture	A type of fracture in which the break is in three or more pieces and fragments are present at the fracture site.		hp.json		http://purl.obolibrary.org/obo/HP_4000048		
HP:0010280	biolink:PhenotypicFeature	Stomatitis	Stomatitis is an inflammation of the mucous membranes of any of the structures in the mouth.	MSH:D013280|UMLS:C0038362|UMLS:C0149704|SNOMEDCT_US:20607006|SNOMEDCT_US:61170000	hp.json	Gingivostomatitis|Inflammation of the mouth	http://purl.obolibrary.org/obo/HP_0010280		hposlim_core
HP:0034251	biolink:PhenotypicFeature	Abnormal corneal reflex	An anomaly of the corneal reflex that normally induces involuntary blinking of the eyelids following contact of the cornea.		hp.json		http://purl.obolibrary.org/obo/HP_0034251		
HP:0009295	biolink:PhenotypicFeature	Short middle phalanx of the 4th finger	Hypoplastic/small middle phalanx of the 4th finger, also known as the ring finger.	UMLS:C4021497	hp.json	Hypoplastic/small middle phalanx of ring finger|Brachymesophalangy IV (finger)|Short middle phalanx of ring finger|Hypoplastic/small middle phalanx of the 4th finger|Short middle bone of 4th finger	http://purl.obolibrary.org/obo/HP_0009295		
HP:0009290	biolink:PhenotypicFeature	Short distal phalanx of the 4th finger	Hypoplastic/small distal phalanx of the fourth finger.	UMLS:C4021499	hp.json	Short distal phalanx of the fourth finger|Hypoplastic/small distal phalanx of the 4th finger|Short outermost bone of ring finger	http://purl.obolibrary.org/obo/HP_0009290		
HP:0009292	biolink:PhenotypicFeature	Broad distal phalanx of the 4th finger	Increased width of the distal phalanx of the 4th finger.	UMLS:C4024464	hp.json	Wide outermost bone of ring finger|Broad outermost bone of ring finger	http://purl.obolibrary.org/obo/HP_0009292		
HP:0009291	biolink:PhenotypicFeature	Aplasia of the distal phalanx of the 4th finger	Absence of the distal phalanx of the ring (4th) finger.	UMLS:C4024465	hp.json	Absent outermost bone of ring finger	http://purl.obolibrary.org/obo/HP_0009291		
HP:0034258	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the midbrain	Absence or underdevelopment of the midbrain (mesencephalon).		hp.json	Aplasia/Hypoplasia of the mesencephalon	http://purl.obolibrary.org/obo/HP_0034258		
HP:0034257	biolink:PhenotypicFeature	C4 nephritic factor positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that recognize C4b2a, the C3 convertase of the classical pathway of complement.		hp.json		http://purl.obolibrary.org/obo/HP_0034257		
HP:0010289	biolink:PhenotypicFeature	Cleft of alveolar ridge of maxilla	A gap (cleft) affecting one of the alveolar ridges, which are the protuberances in the mouth that contain the sockets (alveoli) of the teeth. An alveolar cleft can affect all structures of the alveolar ridge, including the gingiva, other mucosa, periosteum, alveolar bone, and teeth.	UMLS:C2919907|SNOMEDCT_US:445306000|UMLS:C4280386|UMLS:C1398533	hp.json	Cleft of alveolar process|Notch of alveolar process|Notch of gum ridge|Cleft of gum ridge|Notch of alveolar ridge|Alveolar ridge cleft	http://purl.obolibrary.org/obo/HP_0010289		hposlim_core
HP:0034259	biolink:PhenotypicFeature	Hypoplasia of the midbrain	A developmental defect characterized by underdevelopment of the mesencephalon.		hp.json	Hypoplasia of the mesencephalon|Hypoplastic mesencephalon	http://purl.obolibrary.org/obo/HP_0034259		
HP:0010288	biolink:PhenotypicFeature	Abnormality of the sublingual glands	Any abnormality of the sublingual glands, which are the salivary glands that are located beneath the floor of the mouth anterior to the submandibular glands.	UMLS:C4023919	hp.json		http://purl.obolibrary.org/obo/HP_0010288		
HP:0034254	biolink:PhenotypicFeature	Face of the giant panda sign	The face of the giant panda sign on T2-weighted MRI is characterized by preservation of normal signal intensity in the red nuclei and lateral portion of the pars reticulata of the substantia nigra, high signal in the tegmentum, and hypointensity of the superior colliculus. The findings are said to resemble the face of a giant panda.		hp.json	Midbrain panda sign	http://purl.obolibrary.org/obo/HP_0034254		
HP:0010287	biolink:PhenotypicFeature	Abnormality of the submandibular glands	Any abnormality of the submandibular glands, which are the salivary glands that are located beneath the floor of the mouth, superior to the digastric muscles.	UMLS:C4023920	hp.json	Abnormality of the submaxillary glands	http://purl.obolibrary.org/obo/HP_0010287		
PR:P53566	biolink:Protein	CCAAT/enhancer-binding protein alpha (mouse)	A CCAAT/enhancer-binding protein alpha that is encoded in the genome of mouse.	UniProtKB:P53566	hp.json	mCEBPA|Cebpa|Cebp|C/EBP alpha (mouse)	http://purl.obolibrary.org/obo/PR_P53566		
HP:0010286	biolink:PhenotypicFeature	Abnormal salivary gland morphology	Any abnormality of the salivary glands, the exocrine glands that produce saliva.	SNOMEDCT_US:10890000|UMLS:C0149772|MSH:D012466|UMLS:C0036093	hp.json	Salivary gland disease|Abnormality of the salivary glands	http://purl.obolibrary.org/obo/HP_0010286		hposlim_core
HP:0034253	biolink:PhenotypicFeature	Eosinophil nuclear hypersegmentation	An excessive division of the lobes of the nucleus of eosinophils. Eosinophils with more than two nuclear lobes are commonly regarded as hypersegmented, because seventy to ninety percent of peripheral blood eosinophils have two nuclear lobes.		hp.json		http://purl.obolibrary.org/obo/HP_0034253		
HP:0034256	biolink:PhenotypicFeature	Absent dermoepidermal hemidesmosomes	Lack of demonstrable hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin.		hp.json		http://purl.obolibrary.org/obo/HP_0034256		
HP:0010285	biolink:PhenotypicFeature	Oral synechia	Fibrous band between the mucosal surfaces of the upper and lower alveolar ridges.	UMLS:C4023921	hp.json	Synechiae of the mouth|Oral fibrous bands	http://purl.obolibrary.org/obo/HP_0010285		hposlim_core
HP:0010284	biolink:PhenotypicFeature	Intra-oral hyperpigmentation	Increased pigmentation, either focal or generalized, of the mucosa of the mouth.	UMLS:C4280389|UMLS:C4280388|UMLS:C4280387|UMLS:C0399483|UMLS:C0877541|SNOMEDCT_US:235038002	hp.json	Gingival hyperpigmentation|Pigmented gums|Dark color of gums|Oral racial pigmentation|Hyperpigmentation of oral mucosa|Gingival melanin pigmentation|Oral mucosa melanin pigmentation|Dark colour of gums	http://purl.obolibrary.org/obo/HP_0010284		hposlim_core
HP:0034255	biolink:PhenotypicFeature	Colovesicular fistula	An aberrant, pathological communication between the colon and the bladder.		hp.json	Vesicocolic fistula	http://purl.obolibrary.org/obo/HP_0034255		
HP:4000041	biolink:PhenotypicFeature	AA amyloidosis	Extracellular tissue deposition of fibrils that are composed of fragments of and/or intact serum amyloid A protein, a hepatic acute phase reactant.		hp.json		http://purl.obolibrary.org/obo/HP_4000041		
HP:4000042	biolink:PhenotypicFeature	Fracture type	Category of fracture. Terms from this subontology can be used together with terms in the subontology that descends from Bone fracture (HP:0020110).		hp.json		http://purl.obolibrary.org/obo/HP_4000042		
HP:4000040	biolink:PhenotypicFeature	Puerpural onset	Onset of a phenotypic abnormality or a disease during childbirth or in the period immediately following.		hp.json		http://purl.obolibrary.org/obo/HP_4000040		
HP:0009287	biolink:PhenotypicFeature	Curved middle phalanx of the 4th finger	Curved appearance of the middle phalanx of the 4th (ring) finger.	UMLS:C4024468	hp.json	Curved middle ring finger bone	http://purl.obolibrary.org/obo/HP_0009287		
HP:4000045	biolink:PhenotypicFeature	Spiral fracture	A type of fracture in which the break spirals around the bone.		hp.json		http://purl.obolibrary.org/obo/HP_4000045		
HP:0009286	biolink:PhenotypicFeature	Curved distal phalanx of the 4th finger	Curved appearance of the distal phalanx of the 4th (ring) finger.	UMLS:C4024469	hp.json	Curved outermost ring finger bone	http://purl.obolibrary.org/obo/HP_0009286		
HP:4000046	biolink:PhenotypicFeature	Oblique fracture	A type of fracture in which there is a diagonal break across the bone.		hp.json		http://purl.obolibrary.org/obo/HP_4000046		
HP:0009289	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the 4th finger		UMLS:C4024466	hp.json	Absent/underdeveloped outermost ring finger bone|Absent/small outermost ring finger bone	http://purl.obolibrary.org/obo/HP_0009289		
HP:4000043	biolink:PhenotypicFeature	Greenstick fracture	A type of fracture in which the broken bone is not completely separated.		hp.json	Incomplete fracture	http://purl.obolibrary.org/obo/HP_4000043		
HP:0009288	biolink:PhenotypicFeature	Curved proximal phalanx of the 4th finger		UMLS:C4024467	hp.json	Curved innermost ring finger bone	http://purl.obolibrary.org/obo/HP_0009288		
HP:4000044	biolink:PhenotypicFeature	Transverse fracture	A type of fracture in which the break is in a straight line across the bone.		hp.json		http://purl.obolibrary.org/obo/HP_4000044		
HP:0034261	biolink:PhenotypicFeature	Aplasia/Hypoplasia of facial bones	A developmental defect characterized by absence or underdevelopment of one or more facial bone.		hp.json		http://purl.obolibrary.org/obo/HP_0034261		
HP:4000038	biolink:PhenotypicFeature	Infantile hydrocele	Infantile Hydrocele is a type pf hydrocele in which the processus vaginalis gets obliterated at the level of the deep inguinal ring. However, the portion distal to it remains patent and allows fluid accumulation.		hp.json		http://purl.obolibrary.org/obo/HP_4000038		
HP:0010272	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the proximal phalanges of the hand		UMLS:C4023929	hp.json	Fragmentation of the end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010272		
HP:0034260	biolink:PhenotypicFeature	Aplastic zygomatic arch	Developmental defect characterized by the absence of the zygomatic arch.		hp.json		http://purl.obolibrary.org/obo/HP_0034260		
HP:4000039	biolink:PhenotypicFeature	Reduced proportion of mucosal-associated invariant T cells	A decreased proportion of circulating mucosal-associated invariant T (MAIT) cells relative to total T cell count.		hp.json		http://purl.obolibrary.org/obo/HP_4000039		
HP:0010271	biolink:PhenotypicFeature	Enlarged epiphyses of the proximal phalanges of the hand		UMLS:C4023930	hp.json	Enlarged end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010271		
HP:4000036	biolink:PhenotypicFeature	Encysted hydrocele of the cord	A type of hydrocele testis in which both the proximal and distal portions of processus vaginalis get obliterated while the central portion remains patent and fluid accumulates within it.		hp.json		http://purl.obolibrary.org/obo/HP_4000036		
HP:0010270	biolink:PhenotypicFeature	Cone-shaped epiphyses of the proximal phalanges of the hand		UMLS:C4023931	hp.json	Cone-shaped end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010270		
CHEBI:76414	biolink:ChemicalSubstance	propellant	A compressed gas or liquid with a boiling point lower than room temperature which to used to propel and dispense liquids such as deodorants, insecticides, paints, etc. from aerosol cans.	PMID:24001847|PMID:22519407	hp.json	propellants	http://purl.obolibrary.org/obo/CHEBI_76414		3_STAR
HP:0034263	biolink:PhenotypicFeature	Abnormal vaginal bleeding	Abnormal vaginal bleeding occurs between menstrual periods, after sex, or after menopause. Menstrual periods that are heavier or last longer than usual or last more than seven days also are considered abnormal.		hp.json		http://purl.obolibrary.org/obo/HP_0034263		
HP:4000037	biolink:PhenotypicFeature	Congenital hydrocele	Congenital hydrocele occurs when processus vaginalis is patent and communicates with the peritoneal cavity. This communication allows the movement of peritoneal fluid but is too small to allow the intra-abdominal contents to herniate through.		hp.json		http://purl.obolibrary.org/obo/HP_4000037		
HP:0034262	biolink:PhenotypicFeature	Absent lanugo	Lack of development of lanugo, the fine, soft, unpigmented hair on the body of a fetus or newborn baby.		hp.json		http://purl.obolibrary.org/obo/HP_0034262		
HP:0034269	biolink:PhenotypicFeature	Abnormal vaginal discharge	Anomalous amount, odor, or consistency of the fluid or mucus that comes from the vagina		hp.json		http://purl.obolibrary.org/obo/HP_0034269		
HP:0034268	biolink:PhenotypicFeature	Abnormal vaginal physiology	Any anomaly of vagina function.		hp.json		http://purl.obolibrary.org/obo/HP_0034268		
HP:0010278	biolink:PhenotypicFeature	Triangular epiphyses of the proximal phalanges of the hand		UMLS:C4023923	hp.json	Triangular end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010278		
HP:0010277	biolink:PhenotypicFeature	Stippling of the epiphyses of the proximal phalanges of the hand		UMLS:C4023924	hp.json	Speckled calcifications in the end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010277		
HP:0010276	biolink:PhenotypicFeature	Small epiphyses of the proximal phalanges of the hand		UMLS:C4023925	hp.json	Small end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010276		
HP:0034265	biolink:PhenotypicFeature	Mastalgia	Pain in the breast.		hp.json	Breast pain|Painful breast	http://purl.obolibrary.org/obo/HP_0034265		
HP:0010275	biolink:PhenotypicFeature	Pseudoepiphyses of the proximal phalanges of the hand	A secondary ossification center in the proximal phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4023926	hp.json		http://purl.obolibrary.org/obo/HP_0010275		
HP:0034264	biolink:PhenotypicFeature	Postcoital vaginal bleeding	Postcoital bleeding (PCB) consists of spotting or bleeding after sexual intercourse that is not related to a person's menstrual cycle.		hp.json	Bleeding after sex	http://purl.obolibrary.org/obo/HP_0034264		
HP:0010274	biolink:PhenotypicFeature	Ivory epiphyses of the proximal phalanges of the hand	Epiphyses of the proximal phalanges of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.	UMLS:C4023927	hp.json	Increased bone density of end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010274		
HP:0034267	biolink:PhenotypicFeature	Pelvic pain	Pain perceived in the area of the pelvis, the lower part of the abdomen located between the hip bones.		hp.json	Pain in the pelvis	http://purl.obolibrary.org/obo/HP_0034267		
HP:0034266	biolink:PhenotypicFeature	Vaginal bleeding during sex	Bleeding during sex.		hp.json		http://purl.obolibrary.org/obo/HP_0034266		
HP:0010273	biolink:PhenotypicFeature	Irregular epiphyses of the proximal phalanges of the hand		UMLS:C4023928	hp.json	Irregular end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010273		
HP:4000030	biolink:PhenotypicFeature	Anti-reticulin antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against reticulin.		hp.json		http://purl.obolibrary.org/obo/HP_4000030		
HP:4000031	biolink:PhenotypicFeature	Anti-type VII collagen antibody	The presence of autoantibodies (immunoglobulins) in the serum that react against collagen type VII.		hp.json		http://purl.obolibrary.org/obo/HP_4000031		
HP:4000034	biolink:PhenotypicFeature	Infection-ssociated lymphopenia	Decreased lymphocyte count during infections.		hp.json	Infection-ssociated lymphocytopenia	http://purl.obolibrary.org/obo/HP_4000034		
HP:0009298	biolink:PhenotypicFeature	Aplasia of the proximal phalanx of the 4th finger	Absence of the proximal phalanx of the ring (4th) finger.	UMLS:C4024460	hp.json	Absent innermost ring finger bone	http://purl.obolibrary.org/obo/HP_0009298		
CHEBI:76413	biolink:ChemicalSubstance	greenhouse gas	A gas in an atmosphere that absorbs and emits radiation within the thermal infrared range, so contributing to the 'greenhouse effect'.	Wikipedia:Greenhouse_gas	hp.json	greenhouse gases	http://purl.obolibrary.org/obo/CHEBI_76413		3_STAR
HP:0009297	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanx of the 4th finger	Dissolution or degeneration of bone tissue of the middle phalanx of the 4th finger.	UMLS:C4024461	hp.json		http://purl.obolibrary.org/obo/HP_0009297		
HP:4000035	biolink:PhenotypicFeature	Primary obstructive megaureter	Megaurater associated with obstruction or an adynamic ureteral segment in the ureterovesical junction.		hp.json		http://purl.obolibrary.org/obo/HP_4000035		
HP:4000032	biolink:PhenotypicFeature	False perception of self-motion	A perception that one's body is moving or swaying despite lack of motion of the body.		hp.json		http://purl.obolibrary.org/obo/HP_4000032		
HP:4000033	biolink:PhenotypicFeature	Non-spinning vertigo	A perception of unsteadiness of dizziness that is not characterized bythe spinning sensation of classic vertigo, but rather by an oscillatory perception (rocking, bobbing, or swaying despite the fact that the subject is not moving).		hp.json		http://purl.obolibrary.org/obo/HP_4000033		
HP:0009299	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanx of the 4th finger		UMLS:C4024459	hp.json	Absent/underdeveloped middle ring finger bone|Absent/small middle ring finger bone	http://purl.obolibrary.org/obo/HP_0009299		
HP:0010261	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the middle phalanges of the hand	Fragmented appearance of the epiphyses of the middle phalanges of the hand.	UMLS:C4023940	hp.json	Fragmentation of the end part of the middle hand bones	http://purl.obolibrary.org/obo/HP_0010261		
HP:0009272	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 4th finger	A small/hypoplastic or absent/aplastic 4th (ring) finger.	UMLS:C4024478	hp.json	Absent/underdeveloped ring finger bone|Absent/small ring finger bone	http://purl.obolibrary.org/obo/HP_0009272		
HP:0034272	biolink:PhenotypicFeature	Perifoveal hypoautofluorescence	Decreased amount of autofluorescence (emission of fluorescent light from ocular structures in the absence of sodium fluorescein) in the retina in the region surrounding the fovea.		hp.json		http://purl.obolibrary.org/obo/HP_0034272		
HP:4000027	biolink:PhenotypicFeature	anti-LAD-1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against LAD-1, which is the soluble 120 kDa ectodomain of BP180.		hp.json		http://purl.obolibrary.org/obo/HP_4000027		
HP:0009271	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the 4th finger	A triangular appearance of the epiphysis of the proximal phalanx of the ring finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4021505	hp.json	Triangular end part of the innermost bone of ring finger|Delta-shaped epiphysis of the proximal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009271		
HP:0010260	biolink:PhenotypicFeature	Enlarged epiphyses of the middle phalanges of the hand		UMLS:C4023941	hp.json	Enlarged end part of the middle hand bones	http://purl.obolibrary.org/obo/HP_0010260		
HP:0034271	biolink:PhenotypicFeature	Copper beaten skull	Diffuse prominent gyral impressions on the inner table of skull vault said to resemble beaten copper.		hp.json		http://purl.obolibrary.org/obo/HP_0034271		
HP:4000028	biolink:PhenotypicFeature	Anti-LABD97 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against LABD97, which is structurally identical to a portion of the extracellular domain of BPAg2. BPAg2, a 180 kDa bullous pemphigoid antigen, is a transmembrane protein important for basement membrane cohesion.		hp.json		http://purl.obolibrary.org/obo/HP_4000028		
HP:4000025	biolink:PhenotypicFeature	Anti-integrin antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against an integrin. Integrins are a family of cell adhesion moleculeswith 24 known integrin heterodimers. Integrins transduce mechanical and biochemical signals from fibrotic extracellular matrix into the cell, activate latent TGFbeta, and subsequently modulate fibroblast adhesion, migration, and growth.		hp.json		http://purl.obolibrary.org/obo/HP_4000025		
HP:0009274	biolink:PhenotypicFeature	Joint contracture of the 4th finger	Chronic loss of joint motion in the 4th finger due to structural changes in non-bony tissue. The term camptodactyly of the 4th finger is used if the distal and/or proximal interphalangeal joints are affected.	UMLS:C4021504	hp.json	Joint contractures of the fourth finger	http://purl.obolibrary.org/obo/HP_0009274		
HP:0034274	biolink:PhenotypicFeature	Gastrointestinal ulcer	A deep defect in the esophageal, gastric, duodenal or intestinal wall involving the entire mucosal thickness and penetrating through the muscularis mucosae.		hp.json		http://purl.obolibrary.org/obo/HP_0034274		
HP:0034273	biolink:PhenotypicFeature	Premature sagging cheeks	Drooping or sinking of tissues of the cheeks more than would be expected at a given age. Sagging can occur due to a relative excess of skin and/or lack of elastic recoil as well as fat accumulation.		hp.json	Premature facial sagging	http://purl.obolibrary.org/obo/HP_0034273		
HP:0009273	biolink:PhenotypicFeature	Deviation of the 4th finger	Displacement of the 4th finger from its normal position.	UMLS:C4024477	hp.json	Deviation of the ring finger	http://purl.obolibrary.org/obo/HP_0009273		
HP:4000026	biolink:PhenotypicFeature	Anti-transglutaminase 6 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against transglutaminase 6.		hp.json		http://purl.obolibrary.org/obo/HP_4000026		
PR:000014841	biolink:Protein	sonic hedgehog protein	A protein that is a translation product of the human SHH gene or a 1:1 ortholog thereof.		hp.json	SHH|Hhg1|Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains|HHG-1|ShhNC	http://purl.obolibrary.org/obo/PR_000014841		
HP:0009270	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the 4th finger	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 4th finger.	UMLS:C4024479	hp.json	Speckled calcifications in end part of the innermost bone of ring finger	http://purl.obolibrary.org/obo/HP_0009270		
HP:0034270	biolink:PhenotypicFeature	Serrated incisors	Incisor teeth with irregular edges said to resemble a saw.		hp.json	Jagged incisors	http://purl.obolibrary.org/obo/HP_0034270		
HP:4000029	biolink:PhenotypicFeature	Antigliadin antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against gliadin.		hp.json	AGA autoantibodies	http://purl.obolibrary.org/obo/HP_4000029		
HP:0010269	biolink:PhenotypicFeature	Bracket epiphyses of the proximal phalanges of the hand	An abnormality of the proximal phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4023932	hp.json	Bracket shaped end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010269		
HP:0010268	biolink:PhenotypicFeature	Absent epiphyses of the proximal phalanges of the hand		UMLS:C4023933	hp.json	Absent end part of the innermost hand bones	http://purl.obolibrary.org/obo/HP_0010268		
HP:0034279	biolink:PhenotypicFeature	2,8-dihydroxyadenine crystalluria	The presence of 2,8-dihydroxyadenine crystals in the urine. The crystals appear as round, yellow-brown crystals.		hp.json	2,8-dihydroxyadenine urinary crystals	http://purl.obolibrary.org/obo/HP_0034279		
HP:0010267	biolink:PhenotypicFeature	Triangular epiphyses of the middle phalanges of the hand		UMLS:C4023934	hp.json	Triangular end part of the middle hand bones	http://purl.obolibrary.org/obo/HP_0010267		
HP:0010266	biolink:PhenotypicFeature	Stippling of the epiphyses of the middle phalanges of the hand		UMLS:C4023935	hp.json	Speckled calcifications in the end part of the middle hand bones	http://purl.obolibrary.org/obo/HP_0010266		
HP:0010265	biolink:PhenotypicFeature	Small epiphyses of the middle phalanges of the hand		UMLS:C4023936	hp.json	Small end part of the middle hand bones	http://purl.obolibrary.org/obo/HP_0010265		
HP:0034276	biolink:PhenotypicFeature	Elevated circulating thymidine concentration	Concentration of thymidine in the blood circulation above the normal range.		hp.json	Increased serum thymidine	http://purl.obolibrary.org/obo/HP_0034276		
HP:0034275	biolink:PhenotypicFeature	Verrucous epidermal nevus	A type of epidermal nevus (which represent Blaschkoid hamartomas of the skin that result from mosaic post-zygotic mutations) that appears as skin-colored-to-brown, sharply demarcated, papillomatous papules that coalesce into plaques. The majority of these nevi are either present at birth or occur within the first year of life.		hp.json		http://purl.obolibrary.org/obo/HP_0034275		
HP:0010264	biolink:PhenotypicFeature	Pseudoepiphyses of the middle phalanges of the hand	A secondary ossification center in the middle phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4023937	hp.json		http://purl.obolibrary.org/obo/HP_0010264		
HP:0034278	biolink:PhenotypicFeature	Multinucleated erythroblast	Erythroblasts with multiple nuclei. Erythroblasts are nucleated precrusor cells of erythrocytes that are localized to the bone marrow. Normally, erythroblasts have a single nucleus. The abnormal finding of erythrocytes with two or more nuclei may be related to defects in cytokinesis.		hp.json	Multinucleate erythroblast	http://purl.obolibrary.org/obo/HP_0034278		
HP:0010263	biolink:PhenotypicFeature	Ivory epiphyses of the middle phalanges of the hand	Epiphyses of the middle phalanges of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.	UMLS:C4023938	hp.json	Increased bone density of end part of the middle hand bones	http://purl.obolibrary.org/obo/HP_0010263		
HP:0034277	biolink:PhenotypicFeature	Elevated circulating deoxyuridine concentration	Concentration of 2-deoxyuridine in the blood circulation is above the normal range.		hp.json		http://purl.obolibrary.org/obo/HP_0034277		
HP:0010262	biolink:PhenotypicFeature	Irregular epiphyses of the middle phalanges of the hand		UMLS:C4023939	hp.json	Irregular end part of middle hand bones	http://purl.obolibrary.org/obo/HP_0010262		
HP:0009269	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the 4th finger	Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger with respect to age-dependent norms.	UMLS:C4024480	hp.json	Small end part of the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009269		
HP:4000020	biolink:PhenotypicFeature	Anti-BP180 antibody positivity	Bullous pemphigoid (BP) is an autoimmune disease associated with subepidermal blistering due to autoantibodies directed against BP180 and BP230. BP180 is currently considered as the major pathogenic autoantigen.		hp.json		http://purl.obolibrary.org/obo/HP_4000020		
HP:0009268	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the 4th finger	A secondary ossification center in the proximal phalanx of the fourth finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4024481	hp.json		http://purl.obolibrary.org/obo/HP_0009268		
HP:0009265	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the 4th finger	Fragmented appearance of the epiphysis of the proximal phalanx of the 4th finger.	UMLS:C4024484	hp.json	Fragmentation of end part of the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009265		
HP:4000023	biolink:PhenotypicFeature	Anti-laminin gamma1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against laminin gamma-1.		hp.json		http://purl.obolibrary.org/obo/HP_4000023		
HP:0009264	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the 4th finger	Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger with respect to age-dependent norms.	UMLS:C4024485	hp.json	Enlarged end part of the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009264		
HP:4000024	biolink:PhenotypicFeature	Anti-laminin antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against a laminin. Laminins are major components of the basement membrane.		hp.json		http://purl.obolibrary.org/obo/HP_4000024		
HP:0009267	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the 4th finger	Sclerosis of the epiphysis of the proximal phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024482	hp.json	Increased bone density of end part of the innermost ring finger bone	http://purl.obolibrary.org/obo/HP_0009267		
HP:4000021	biolink:PhenotypicFeature	Anti-laminin 332 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against laminin-332.		hp.json	Anti-laminin 5 antibody positivity	http://purl.obolibrary.org/obo/HP_4000021		
HP:0009266	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the 4th finger	Irregular radiographic opacity of the epiphysis of the proximal phalanx of the 4th finger.	UMLS:C4024483	hp.json	Irregular end part of the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009266		
HP:4000022	biolink:PhenotypicFeature	Anti-laminin 6 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against laminin-6.		hp.json		http://purl.obolibrary.org/obo/HP_4000022		
HP:0034283	biolink:PhenotypicFeature	Increased fecal protoporphyrin concentration	Abnormally high concentration of protoporphyrin (derivative of porphyrin with propionic acid groups) in feces.		hp.json		http://purl.obolibrary.org/obo/HP_0034283		
HP:0010250	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the distal phalanges of the hand		UMLS:C4023949	hp.json	Fragmentation of the end part of the outermost hand bones	http://purl.obolibrary.org/obo/HP_0010250		
HP:0009283	biolink:PhenotypicFeature	Abnormality of the middle phalanx of the 4th finger		UMLS:C4021501	hp.json	Abnormality of the middle phalanx of the ring finger|Abnormal middle bone of ring finger	http://purl.obolibrary.org/obo/HP_0009283		
HP:4000016	biolink:PhenotypicFeature	Anti-periplakin antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against periplakin.		hp.json		http://purl.obolibrary.org/obo/HP_4000016		
HP:0009282	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the 4th finger		UMLS:C4024471	hp.json	Abnormality of the outermost bone of ring finger	http://purl.obolibrary.org/obo/HP_0009282		
UBERON:0010190	biolink:AnatomicalEntity	pair of dorsal aortae	The paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation.	MA:0000476|EHDAA2:0000410|EMAPA:18606	hp.json	paired dorsal aortae	http://purl.obolibrary.org/obo/UBERON_0010190		pheno_slim
HP:0034282	biolink:PhenotypicFeature	Subcutaneous ossification	Formation of abnormal, extraskeletal bony tissue in the soft tissue beneath the skin. Subcutaneous ossifications may be observed by radiography or by palpation.		hp.json		http://purl.obolibrary.org/obo/HP_0034282		
HP:4000017	biolink:PhenotypicFeature	Anti-desmoplakin I antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against desmoplakin-1.		hp.json		http://purl.obolibrary.org/obo/HP_4000017		
HP:0009285	biolink:PhenotypicFeature	Curved phalanges of the 4th finger	Curved appearance of the phalanges of the 4th (ring) finger.	UMLS:C4024470	hp.json	Curved ring finger bone	http://purl.obolibrary.org/obo/HP_0009285		
HP:4000014	biolink:PhenotypicFeature	Anti-desmoglein-3 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against desmoglein-3, a dermal cell adhesion molecule.		hp.json		http://purl.obolibrary.org/obo/HP_4000014		
HP:0034285	biolink:PhenotypicFeature	Enteroviral encephalitis	Inflamation of the brain related to infection by an enterovirus.		hp.json		http://purl.obolibrary.org/obo/HP_0034285		
HP:0034284	biolink:PhenotypicFeature	Recurrent gingivitis	Repeated occurrences of inflammatory condition of the gums (gingival tissue), most commonly caused by bacterial infection.		hp.json		http://purl.obolibrary.org/obo/HP_0034284		
HP:0009284	biolink:PhenotypicFeature	Abnormality of the proximal phalanx of the 4th finger		UMLS:C4021500	hp.json	Abnormality of the proximal phalanx of the ring finger|Abnormal innermost bone of ring finger	http://purl.obolibrary.org/obo/HP_0009284		
HP:4000015	biolink:PhenotypicFeature	Anti-envoplakin antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against envoplakin, a cytoskeletal linker protein that links intermediate filaments to cellular junctions.		hp.json		http://purl.obolibrary.org/obo/HP_4000015		
UBERON:0010194	biolink:AnatomicalEntity	hepatic portal system	A portal system that begins in capillaries in the wall of the digestive tract and and runs as the hepatic portal vein to the liver.	AAO:0010225	hp.json	hepatic-portal system|portal system of liver	http://purl.obolibrary.org/obo/UBERON_0010194		
HP:0009281	biolink:PhenotypicFeature	Aplasia of the 4th finger	Absent 4th finger.	UMLS:C4024472	hp.json	Absent ring finger	http://purl.obolibrary.org/obo/HP_0009281		
HP:0034281	biolink:PhenotypicFeature	Phalangeal cone-shaped epiphyses	Cone-shaped epiphyses of the phalanges of the hands or feet. Cone-shaped epiphyses (also known as coned epiphyses) are epiphyses that invaginate into cupped metaphyses. That is, the epiphysis has a cone-shaped distal extension resulting from increased growth of the central portion of the epiphysis relative to its periphery.		hp.json	Cone-shaped epiphyses of phalanges|Cone-shaped phalangeal epiphyses	http://purl.obolibrary.org/obo/HP_0034281		
HP:4000018	biolink:PhenotypicFeature	Anti-desmoplakin II antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against desmoplakin-II.		hp.json		http://purl.obolibrary.org/obo/HP_4000018		
UBERON:0010191	biolink:AnatomicalEntity	aortic system		EHDAA2:0004512	hp.json		http://purl.obolibrary.org/obo/UBERON_0010191		
UBERON:0010192	biolink:AnatomicalEntity	genital artery	One of the laterally paired arteries that supply the gonads.	Wikipedia:Gonadal_artery	hp.json	gonadal artery	http://purl.obolibrary.org/obo/UBERON_0010192		
HP:0009280	biolink:PhenotypicFeature	Short 4th finger	Hypoplasia (congenital reduction in size) of the fourth finger, also known as the ring finger.	UMLS:C4021502	hp.json	Short ring finger|Hypoplastic/small 4th finger	http://purl.obolibrary.org/obo/HP_0009280		
HP:4000019	biolink:PhenotypicFeature	Anti-BP230 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against BP230.		hp.json		http://purl.obolibrary.org/obo/HP_4000019		
HP:0034280	biolink:PhenotypicFeature	Target cells	Target cells (codocytes) have a centrally located disk of hemoglobin surrounded by an area of pallor with an outer rim of hemoglobin adjacent to the cell membrane giving the cell the appearance of a target.		hp.json	Codocytes	http://purl.obolibrary.org/obo/HP_0034280		
HP:0010258	biolink:PhenotypicFeature	Bracket epiphyses of the middle phalanges of the hand	An abnormality of the middle phalanges of the hand in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4023942	hp.json	Bracket shaped end part of the middle hand bones	http://purl.obolibrary.org/obo/HP_0010258		
HP:0010257	biolink:PhenotypicFeature	Absent epiphyses of the middle phalanges of the hand		UMLS:C4023943	hp.json	Absent end part of the middle hand bones	http://purl.obolibrary.org/obo/HP_0010257		
HP:0010256	biolink:PhenotypicFeature	Triangular epiphyses of the distal phalanges of the hand		UMLS:C4023944	hp.json	Triangular end part of the outermost hand bones	http://purl.obolibrary.org/obo/HP_0010256		
HP:0010255	biolink:PhenotypicFeature	Stippling of the epiphyses of the distal phalanges of the hand		UMLS:C4023945	hp.json	Speckled calcifications in the end part of the outermost hand bones	http://purl.obolibrary.org/obo/HP_0010255		
HP:0010254	biolink:PhenotypicFeature	Small epiphyses of the distal phalanges of the hand		UMLS:C4023946	hp.json	Small end part of the outermost hand bones	http://purl.obolibrary.org/obo/HP_0010254		
HP:0034287	biolink:PhenotypicFeature	Afibrinogenemia	Lack of detectable fibrinogen in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034287		
HP:0034286	biolink:PhenotypicFeature	Pneumocystis carinii pneumonia	Pneumocystis carinii pneumonia is an opportunistic infection that occurs in immunosuppressed populations.		hp.json		http://purl.obolibrary.org/obo/HP_0034286		
HP:0010253	biolink:PhenotypicFeature	Pseudoepiphyses of the distal phalanges of the hand	A secondary ossification center in the distal phalanges of the hand that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone.	UMLS:C4023947	hp.json		http://purl.obolibrary.org/obo/HP_0010253		
UBERON:0010199	biolink:AnatomicalEntity	bona-fide anatomical boundary	An anatomical boundary that corresponds to some physical discontinuity.	CARO:0001004	hp.json		http://purl.obolibrary.org/obo/UBERON_0010199		upper_level
HP:0010252	biolink:PhenotypicFeature	Ivory epiphyses of the distal phalanges of the hand	Distal epiphyses of the hand are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.	UMLS:C4021301	hp.json	Increased bone density of end part of the outermost hand bones|Eburnated epiphyses of distal phalanges	http://purl.obolibrary.org/obo/HP_0010252		
HP:0034289	biolink:PhenotypicFeature	Elevated circulating rT3/T3 ratio	An abnormally increased ratio of the concentrations of reverse T3 to T3 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034289		
HP:0034288	biolink:PhenotypicFeature	Elevated circulating reverse T3 concentration	Abnormally increased concentration of reverse T3 (3,3',5'-triiodothyronine or rT3) in the blood circulation.		hp.json	Elevated rT3|Elevated circulating reverse triiodothyronine concentration	http://purl.obolibrary.org/obo/HP_0034288		
HP:0010251	biolink:PhenotypicFeature	Irregular epiphyses of the distal phalanges of the hand		UMLS:C4023948	hp.json	Irregular end part of the outermost hand bones	http://purl.obolibrary.org/obo/HP_0010251		
HP:0010259	biolink:PhenotypicFeature	Cone-shaped epiphyses of the middle phalanges of the hand		UMLS:C1860828	hp.json	Cone-shaped end part of the middle hand bones|Cone-shaped epiphyses of middle phalanges	http://purl.obolibrary.org/obo/HP_0010259		
HP:0009279	biolink:PhenotypicFeature	Radial deviation of the 4th finger	Displacement of the 4th finger towards the radial side (i.e., towards the thumb).	UMLS:C4024473	hp.json	Radial deviation of the ring finger	http://purl.obolibrary.org/obo/HP_0009279		
HP:0009276	biolink:PhenotypicFeature	Contracture of the proximal interphalangeal joint of the 4th finger	Chronic loss of joint motion of the proximal interphalangeal joint of the 4th finger due to structural changes in non-bony tissue. That is, the PIP joint of a fourth finger is bent (flexed) and cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement.	UMLS:C4021503	hp.json	4th finger camptodactyly|Camptodactyly of the 4th finger|Camptodactyly of the ring finger	http://purl.obolibrary.org/obo/HP_0009276		
HP:4000012	biolink:PhenotypicFeature	Necrotizing ileitis			hp.json		http://purl.obolibrary.org/obo/HP_4000012		
HP:0009275	biolink:PhenotypicFeature	Contracture of the distal interphalangeal joint of the 4th finger	Chronic loss of joint motion of the distal interphalangeal joint of the 4th finger due to structural changes in non-bony tissue.	UMLS:C4024476	hp.json		http://purl.obolibrary.org/obo/HP_0009275		
HP:4000013	biolink:PhenotypicFeature	Anti-desmoglein-1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against desmoglein-1, a dermal cell adhesion molecule.		hp.json		http://purl.obolibrary.org/obo/HP_4000013		
HP:4000010	biolink:PhenotypicFeature	Impaired renal tubular reabsorption of bicarbonate	Decreased renal tubular reabsorption of bicarbonate.		hp.json		http://purl.obolibrary.org/obo/HP_4000010		
HP:0009278	biolink:PhenotypicFeature	Ulnar deviation of the 4th finger	Displacement of the 4th finger towards the ulnar side (i.e., towards the 5th finger).	UMLS:C4024474	hp.json	Ulnar deviation of the ring finger	http://purl.obolibrary.org/obo/HP_0009278		
HP:0009277	biolink:PhenotypicFeature	Contracture of the metacarpophalangeal joint of the 4th finger	Chronic loss of joint motion of the metacarpophalangeal joint of the 4th finger due to structural changes in non-bony tissue.	UMLS:C4024475	hp.json		http://purl.obolibrary.org/obo/HP_0009277		
HP:4000011	biolink:PhenotypicFeature	History of congenital HPV infection	A congenital human papillomavirus (HPV) infection of the newborn. Congential HPV infection can manifest as condyloma cuminata in the newborn.		hp.json		http://purl.obolibrary.org/obo/HP_4000011		
HP:4000005	biolink:PhenotypicFeature	Pericardial late gadolinium enhancement	Areas of high signal intensity in magnetic resonance imaging of the pericardium appearing around 10 minutes after injection of the intercellular contrast agent gadolinium.		hp.json		http://purl.obolibrary.org/obo/HP_4000005		
HP:4000006	biolink:PhenotypicFeature	Elevated myocardial native T1	Increased duration of myocardial T1 time without gadolinium contrast. T1 mapping consists of quantifying the T1 relaxation time of a tissue by using analytical expressions of image-based signal intensities. A fundamental principle of MR imaging is that the signal intensity of pixels is based on the relaxation of hydrogen nuclei protons in a static magnetic field. The T1 relaxation times between two tissues vary substantially. Edema, fat infiltration, and fibrosis also cause differences in T1 relaxivity.		hp.json	Prolonged myocardial native T1	http://purl.obolibrary.org/obo/HP_4000006		
HP:4000003	biolink:PhenotypicFeature	Elevated myocardial native T2	Increased duration of myocardial T2 time without gadolinium contrast. Elevated T2, which can detect myocardial edema.		hp.json		http://purl.obolibrary.org/obo/HP_4000003		
HP:4000004	biolink:PhenotypicFeature	Myocardial late gadolinium enhancement	Areas of high signal intensity in magnetic resonance imaging of the heart appearing 10 to 15 minutes after injection of the intercellular contrast agent gadolinium.		hp.json	Delayed myocardial gadolinium enhancement	http://purl.obolibrary.org/obo/HP_4000004		
HP:4000009	biolink:PhenotypicFeature	Kinesiophobia	An excessive, irrational and debilitating fear to carry out a physical movement, due to a feeling of vulnerability to a painful injury or reinjury.		hp.json		http://purl.obolibrary.org/obo/HP_4000009		
HP:4000007	biolink:PhenotypicFeature	Bronchoconstriction	Tightening of smooth muscle surrounding the bronchi and bronchioles with consequent wheezing and shortness of breath.		hp.json	Constriction of the bronchi|Bronchial constriction	http://purl.obolibrary.org/obo/HP_4000007		
HP:4000008	biolink:PhenotypicFeature	Formation of multiple pronuclei during fertilization	Pronuclei formation is a critical process during fertilisation. Normally, there are two pronuclei (2PN), including the paternal pronucleus and the maternal pronucleus, in the zygote after fertilisation. It is generally accepted that multiple pronuclei (MPN) formation is due to the abnormal extrusion of the second polar body or to abnormal fertilisation with multiple sperm. The MPN therefore can cause infertility and recurrent failure of IVF/ICSI.		hp.json		http://purl.obolibrary.org/obo/HP_4000008		
HP:0034214	biolink:PhenotypicFeature	Fetal intraventricular hemorrhage without ventriculomegaly	A type of fetal intraventricular hemorrhage characterized by clear hemorrhage spillover to the ventricles filling less than 50% of the lateral ventricle and without ventriculomegaly of greater than 15 mm in the transverse diameter of the lateral ventricular atrium.		hp.json	Grade II fetal intracranial hemorrhage	http://purl.obolibrary.org/obo/HP_0034214		
HP:0034213	biolink:PhenotypicFeature	Fetal posterior fossa hemorrhage	A type of fetal intracranial hemorrhage that occurs in the posterior cranial fossa, which is the part of the cranial cavity that is located between the foramen magnum and tentorium cerebelli and contains the brainstem and cerebellum.		hp.json		http://purl.obolibrary.org/obo/HP_0034213		
HP:0034216	biolink:PhenotypicFeature	Fetal cerebellar vermis hemorrhage	A type of fetal intracranial hemorrhage that occurs in the vermis of the cerebellum.		hp.json		http://purl.obolibrary.org/obo/HP_0034216		
HP:0034215	biolink:PhenotypicFeature	Fetal cerebellar hemisphere hemorrhage	A type of fetal intracranial hemorrhage that occurs in the hemisphere of the cerebellum.		hp.json		http://purl.obolibrary.org/obo/HP_0034215		
HP:0034210	biolink:PhenotypicFeature	Fetal intraventricular hemorrhage	A type of fetal intracranial hemorrhage with bleeding into the ventricular system of the brain.		hp.json		http://purl.obolibrary.org/obo/HP_0034210		
HP:0034212	biolink:PhenotypicFeature	Fetal extra-axial hemorrhage	A type of fetal intracranial hemorrhage with bleeding that occurs within the skull but outside of the brain tissue itself (into the epidural, subdural, or arachnoid space).		hp.json		http://purl.obolibrary.org/obo/HP_0034212		
HP:0034211	biolink:PhenotypicFeature	Fetal cerebral parenchymal hemorrhage	A type of fetal intracranial hemorrhage with bleeding into the parenchyma (tissue) of the brain.		hp.json		http://purl.obolibrary.org/obo/HP_0034211		
CL:0000287	biolink:Cell	eye photoreceptor cell			hp.json		http://purl.obolibrary.org/obo/CL_0000287		
HP:0034218	biolink:PhenotypicFeature	Fetal intraventricular hemorrhage with ventriculomegaly	A type of fetal intraventricular hemorrhage (IVH) characterized by spillover to ventricles with flooding of 50% or more of one or both lateral ventricles accrued accompanying ventriculomegaly, but with no apparent brain parenchymal injury. This type of IVH may be defined as a diameter exceeding 15 mm in the transverse diameter of the lateral ventricular atrium as visualiuzed by prenatal sonography.		hp.json	Grade III fetal intracranial hemorrhage	http://purl.obolibrary.org/obo/HP_0034218		
HP:0034217	biolink:PhenotypicFeature	Sonographic non-visualized fetal bladder	Inability to visualize the fetal bladder on targeted prenatal sonography examination. The fetal bladder can be visualized with sonography as a midline, fluid-filled structure in the pelvis as early as 10-12 weeks of gestation. The normal fetus voids at least once an hour but never completely empties the urinary bladder. The fetal bladdder should be consistently imaged after 13 weeks of gestation.		hp.json		http://purl.obolibrary.org/obo/HP_0034217		
HP:0034219	biolink:PhenotypicFeature	Fetal intraventricular hemorrhage with periventricular hemorrhage	A type of fetal intraventricular hemorrhage that additionally includes hemorrhage in a large part of the periventricular parenchyma.		hp.json	Grade IV fetal intracranial hemorrhage	http://purl.obolibrary.org/obo/HP_0034219		
PR:000012234	biolink:Protein	phenylalanine-4-hydroxylase	A protein that is a translation product of the human PAH gene or a 1:1 ortholog thereof.	IUPHARobj:1240	hp.json	PAH|Phe-4-monooxygenase	http://purl.obolibrary.org/obo/PR_000012234		
HP:4000001	biolink:PhenotypicFeature	Abnormal cardiac magnetic resonance imaging finding	Abnormal finding by magnetic resonance imaging (MRI), which uses non-ionizing radiation via a strong magnetic field and radio frequency energy to generate three dimensional images. This term comprises findings that are specific to MRI. Findings such as ventricular spetum defect that can be detected by multiple modalities should be coded separately.		hp.json		http://purl.obolibrary.org/obo/HP_4000001		
HP:0034225	biolink:PhenotypicFeature	Reversed end-diastolic umbilical artery flow	An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an reversal of flow in the umbilical artery at the end of diastole (i.e., backwards flow).		hp.json		http://purl.obolibrary.org/obo/HP_0034225		
HP:0034224	biolink:PhenotypicFeature	Absent end-diastolic umbilical artery flow	An anomaly that is visualized by umbilical artery Doppler velocimetry. Flow in the umbilical artery should be in the forward direction in normal circumstances. This anomaly is characterized by an absence of flow in the umbilical artery at the end of diastole.		hp.json		http://purl.obolibrary.org/obo/HP_0034224		
HP:0034227	biolink:PhenotypicFeature	Aortic isthmus hypoplasia	A type of aortic arch hypoplasia whereby the isthmus (arch between the left subclavian and insertion of the patent ductus arteriosus/ligamentum arteriosum) has a diameter of less than 40% of the diameter of the ascending aorta.		hp.json		http://purl.obolibrary.org/obo/HP_0034227		
HP:0034226	biolink:PhenotypicFeature	Champagne cork sign	Characteristic appearance of the chest and abdomen in the sagittal view on prenatal ultrasound when the chest is small and the abdomen protruding.		hp.json		http://purl.obolibrary.org/obo/HP_0034226		
HP:0034221	biolink:PhenotypicFeature	Abnormal temporal lobe morphology	An abnormal strcutural of the zone (lobe) of the cerebral cortex that is located inferior to the lateral fissure on other cerebral hemispheres.		hp.json		http://purl.obolibrary.org/obo/HP_0034221		
HP:0034220	biolink:PhenotypicFeature	Temporal lobe megalencephaly	Expansion of the temporal lobes of the brain along all axes, including rostrocaudal, superoinferior, and mediolateral, resulting in a globular appearance of the brain.		hp.json		http://purl.obolibrary.org/obo/HP_0034220		
HP:0034223	biolink:PhenotypicFeature	Elevated umbilical artery pulsatility	Human umbilical artery (UA) blood flow pulsatility measured by Doppler ultrasound is a widely used biomarker for the detection of elevated placental vascular resistance. Elevated UA pulsatility, which in the most extreme cases manifests as absent or even reversed end-diastolic velocity, is associated with intrauterine growth restriction (IUGR) and still-birth.		hp.json	Elevated umbilical artery Dopplers|Increased umbilical artery pulsatility index	http://purl.obolibrary.org/obo/HP_0034223		
HP:0034222	biolink:PhenotypicFeature	Temporal lobe dysplasia	A developmental defect of the temporal lobe of the cerebral cortex that is characterized by prominent sulcations and radially directed gyrations.		hp.json		http://purl.obolibrary.org/obo/HP_0034222		
CL:0000295	biolink:Cell	somatotropin secreting cell	A peptide hormone secreting cell that produces growth hormone, somatotropin.		hp.json	somatotrophin secreting cell|growth hormone secreting cell	http://purl.obolibrary.org/obo/CL_0000295		
HP:0034229	biolink:PhenotypicFeature	Distal aortic arch hypoplasia	A type of aortic arch hypoplasia whereby the distal aortic arch (arch distal to the ductus arteriosus) has a diameter of less than 60% of the diameter of the ascending aorta.		hp.json		http://purl.obolibrary.org/obo/HP_0034229		
HP:0034228	biolink:PhenotypicFeature	Proximal aortic arch hypoplasia	A type of aortic arch hypoplasia whereby the proximal aortic arch (arch proximal to the origin of the left subclavian artery) has a diameter of less than 60% of the diameter of the ascending aorta.		hp.json		http://purl.obolibrary.org/obo/HP_0034228		
CL:0000293	biolink:Cell	structural cell	A cell whose primary function is to provide structural support, to provide strength and physical integrity to the organism.		hp.json		http://purl.obolibrary.org/obo/CL_0000293		
HP:0034230	biolink:PhenotypicFeature	Inferior crossed fused renal ectopia	A type of cross fused renal ectopia characterized by fusion between the upper pole of the cross-fused ectopic kidney (located more inferiorly relative to the other kidney) and the lower pole of the other orthotopic kidney (located in a more superior position).		hp.json	Type A cross fused renal ectopia	http://purl.obolibrary.org/obo/HP_0034230		
HP:0034236	biolink:PhenotypicFeature	Apnea of prematurity	Recurrent episodes of apnea occurring in infants born less than 37 weeks of gestation, defined specifically as a pause of breathing for more than 15-20 s, or accompanied by oxygen desaturation (SpO2 not more than 80% for at least 4 s) and bradycardia (heart rate less than 2/3 of baseline for at least 4 s), in infants born less than 37 weeks of gestation.		hp.json	AOP	http://purl.obolibrary.org/obo/HP_0034236		
HP:0034235	biolink:PhenotypicFeature	Superior crossed-fused renal ectopia	A type of cross fused renal ectopia in which the ectopic kidney lies superiorly and its lower pole fuses with the upper pole of the normal kidney. The renal pelvis of both kidneys lies anteriorly.		hp.json		http://purl.obolibrary.org/obo/HP_0034235		
HP:0034238	biolink:PhenotypicFeature	Closed neural tube defect	A type of neural tube defect that is covered by skin.		hp.json		http://purl.obolibrary.org/obo/HP_0034238		
HP:0034237	biolink:PhenotypicFeature	Open neural tube defect	A type of neural tube defect that is not covered by skin.		hp.json		http://purl.obolibrary.org/obo/HP_0034237		
HP:0034232	biolink:PhenotypicFeature	Unilateral lump kidney	A type of cross fused renal ectopia where fusion occurs over a wide margin, both renal pelves anteriorly directed and placed more inferiorly.		hp.json	Type C cross fused renal ectopia	http://purl.obolibrary.org/obo/HP_0034232		
HP:0034231	biolink:PhenotypicFeature	Sigmoid kidney	A type of cross fused renal ectopia where the normal side kidney is present superiorly and the direction of pelvic is medial, the kidney which crosses positioned inferiorly with direction of pelvic toward the lateral side. As kidneys fuse after complete rotation on the vertical axis, both renal pelves lie in correct orientation.		hp.json	Type B cross fused renal ectopia|S-shaped kidney	http://purl.obolibrary.org/obo/HP_0034231		
HP:0034234	biolink:PhenotypicFeature	L-shaped kidney	A type of cross fused renal ectopia in which the crossed kidney lies inferiorly and transversely, fused with the lower pole of the normal kidney.		hp.json	Type E cross fused renal ectopia|Tandem kidney	http://purl.obolibrary.org/obo/HP_0034234		
HP:0034233	biolink:PhenotypicFeature	Disc kidney	A type of cross fused renal ectopia in which kidneys fuse along their medial borders.		hp.json	Type D cross fused renal ectopia	http://purl.obolibrary.org/obo/HP_0034233		
HP:0034239	biolink:PhenotypicFeature	Renal vein thrombosis	The presence of a thrombus (blood clot) in the major renal veins or its tributaries, generally leading to passive congestion that develops causes the affected kidney to swell and become engorged, leading to degeneration of nephrons and causing symptoms of flank pain, hematuria, and decreased urine output.		hp.json		http://purl.obolibrary.org/obo/HP_0034239		
ENVO:01000254	biolink:NamedThing	environmental system			hp.json		http://purl.obolibrary.org/obo/ENVO_01000254		
HP:0010294	biolink:PhenotypicFeature	Palate fistula	A fistula which connects the oral cavity and the pharyngeal area via the aspects of the soft palate.	UMLS:C4280385|UMLS:C2032780	hp.json	Palatal hole|Palatal perforation|Hole in roof of mouth	http://purl.obolibrary.org/obo/HP_0010294		
HP:0010293	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the uvula	Underdevelopment or absence of the uvula.	UMLS:C4023917	hp.json	Aplasia/hypoplasia of palatine uvula	http://purl.obolibrary.org/obo/HP_0010293		
HP:0010292	biolink:PhenotypicFeature	Absent uvula	Lack of the uvula.	SNOMEDCT_US:25148007|UMLS:C0266121	hp.json	Uvula aplasia|Congenital absence of uvula|Agenesis of uvula|Absent palatine uvula|Missing uvula	http://purl.obolibrary.org/obo/HP_0010292		hposlim_core
HP:0034241	biolink:PhenotypicFeature	Prenatal death	Death of a fetus in the uterus.		hp.json	Death before birth|Intrauterine death	http://purl.obolibrary.org/obo/HP_0034241		
HP:0034240	biolink:PhenotypicFeature	Fetal neck mass	An abnormal growth (lump) of tissue in the neck region of a fetus. Masses may be simple cystic,, cystic with a few simple septations (fewer than three septations and less than 3-mm thick), cystic with multiple or thick septations (greater than three septations or septations 3-mm-thick or more), a mass that is than is less than 50% solid, and a mass that is 50% solid or more.		hp.json		http://purl.obolibrary.org/obo/HP_0034240		
HP:0010291	biolink:PhenotypicFeature	Prominent palatine ridges	Increased size and/or number of soft tissue folds on the palatal side of the maxillary alveolar ridge.	UMLS:C4021300	hp.json	Prominent lateral palatal folds|Prominent lateral palatal ridges|Prominent palatine folds|Large lateral palatal ridges|Large lateral palatal folds	http://purl.obolibrary.org/obo/HP_0010291		hposlim_core
GO:1904707	biolink:BiologicalProcess	positive regulation of vascular associated smooth muscle cell proliferation	Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.		hp.json	up-regulation of VSMC proliferation|up-regulation of vascular smooth muscle cell proliferation|activation of VSMC proliferation|up regulation of vascular smooth muscle cell proliferation|activation of vascular smooth muscle cell proliferation|upregulation of VSMC proliferation|positive regulation of vascular smooth muscle cell proliferation|upregulation of vascular smooth muscle cell proliferation|positive regulation of VSMC proliferation|up regulation of VSMC proliferation	http://purl.obolibrary.org/obo/GO_1904707		
HP:0010290	biolink:PhenotypicFeature	Short hard palate	Distance between the labial point of the incisive papilla to the midline junction of the hard and soft palate more than 2 SD below the mean (objective) or apparently decreased length of the hard palate (subjective).	UMLS:C4020772|UMLS:C1398301|UMLS:C4023918	hp.json	Hypoplastic palate|Decreased length of hard palate|Short palate	http://purl.obolibrary.org/obo/HP_0010290		
GO:1904706	biolink:BiologicalProcess	negative regulation of vascular associated smooth muscle cell proliferation	Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.		hp.json	downregulation of VSMC proliferation|inhibition of vascular smooth muscle cell proliferation|downregulation of vascular smooth muscle cell proliferation|down regulation of VSMC proliferation|inhibition of VSMC proliferation|negative regulation of VSMC proliferation|down-regulation of VSMC proliferation|down-regulation of vascular smooth muscle cell proliferation|negative regulation of vascular smooth muscle cell proliferation|down regulation of vascular smooth muscle cell proliferation	http://purl.obolibrary.org/obo/GO_1904706		
GO:1904705	biolink:BiologicalProcess	regulation of vascular associated smooth muscle cell proliferation	Any process that modulates the frequency, rate or extent of vascular smooth muscle cell proliferation.		hp.json	regulation of VSMC proliferation|regulation of vascular smooth muscle cell proliferation	http://purl.obolibrary.org/obo/GO_1904705		
HP:0034247	biolink:PhenotypicFeature	Fetal lower urinary tract obstruction	An obstruction in the ureter leading to bladder outlet obstruction. Special criteria are used for lower urinary tract obstruction (LUTO) in the fetus. Prenatal LUTO has classically been suspected on the basis of three ultrasonographic findings: megacystis, dilated posterior urethra (known as the keyhole sign) and hydronephrosis.		hp.json		http://purl.obolibrary.org/obo/HP_0034247		
HP:0034246	biolink:PhenotypicFeature	Fetal scalp mass	An abnormal growth (lump) of tissue that projects from the fetal scalp.		hp.json		http://purl.obolibrary.org/obo/HP_0034246		
HP:0034249	biolink:PhenotypicFeature	Severe influenza infection	An unusually severe infection by an influenza virus.		hp.json		http://purl.obolibrary.org/obo/HP_0034249		
HP:0034248	biolink:PhenotypicFeature	Increased fetal lens echogenicity	Increased echogenicity (increased brightness in the gray-scale sonography image) of the lens of a fetus.		hp.json		http://purl.obolibrary.org/obo/HP_0034248		
HP:0010299	biolink:PhenotypicFeature	Abnormal dentin morphology	Any abnormality of dentin.	UMLS:C4021299	hp.json	Abnormal dentin|Abnormality of dentine|Abnormality of dentin|Dentin anomaly	http://purl.obolibrary.org/obo/HP_0010299		hposlim_core
HP:0010298	biolink:PhenotypicFeature	Smooth tongue	Glossy appearance of the entire tongue surface.	UMLS:C4280383|UMLS:C4280382|UMLS:C4280381|UMLS:C0155964|SNOMEDCT_US:9491003	hp.json	Smooth dorsum of tongue|Atrophy of lingual surface|Atrophy of tongue surface|Smooth surface of tongue|Atrophy of dorsum of tongue|Smooth lingual surface|Smooth tongue	http://purl.obolibrary.org/obo/HP_0010298		hposlim_core
HP:0034243	biolink:PhenotypicFeature	Abnormal fetal pulmonary morphology	An anomlous structural finding of the fetal lungs. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.		hp.json		http://purl.obolibrary.org/obo/HP_0034243		
HP:0010297	biolink:PhenotypicFeature	Bifid tongue	Tongue with a median apical indentation or fork.	SNOMEDCT_US:84557007|UMLS:C4255098|UMLS:C0266111	hp.json	Snake tongue|Bifurcated tongue|Cleft tongue|Split tongue|Bilobed tongue|Forked tongue	http://purl.obolibrary.org/obo/HP_0010297		hposlim_core
HP:0034242	biolink:PhenotypicFeature	Abnormal fetal genitourinary system morphology	An anomlous structural finding of the fetal genitourinary system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.		hp.json		http://purl.obolibrary.org/obo/HP_0034242		
HP:0010296	biolink:PhenotypicFeature	Ankyloglossia	Short or anteriorly attached lingual frenulum, associated with limited mobility of the tongue.	SNOMEDCT_US:67787004|UMLS:C0152415|MSH:D000072676	hp.json	Tongue tied|Tongue tie	http://purl.obolibrary.org/obo/HP_0010296		
HP:0034245	biolink:PhenotypicFeature	Fetal head anomaly			hp.json		http://purl.obolibrary.org/obo/HP_0034245		
HP:0010295	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the tongue	Absence or underdevelopment of the tongue.	UMLS:C4280384|UMLS:C4023916	hp.json	Lingual aplasia/hypoplasia	http://purl.obolibrary.org/obo/HP_0010295		
HP:0034244	biolink:PhenotypicFeature	Gastric pseudomass	At US examination from the second trimester onward, the fetal stomach appears as a uniformly anechoic, sharply circumscribed round structure in the left upper quadrant. However, debris is commonly visualized in the stomach, forming a pseudomass.		hp.json		http://purl.obolibrary.org/obo/HP_0034244		
CHEBI:25699	biolink:ChemicalSubstance	organic ion			hp.json	organic ions	http://purl.obolibrary.org/obo/CHEBI_25699		3_STAR
CHEBI:25698	biolink:ChemicalSubstance	ether	An organooxygen compound with formula ROR, where R is not hydrogen.		hp.json	ethers|ethers|ether	http://purl.obolibrary.org/obo/CHEBI_25698		3_STAR
HP:0007270	biolink:PhenotypicFeature	Atypical absence seizure	An atypical absence seizure is a type of generalised non-motor (absence) seizure characterised by interruption of ongoing activities and reduced responsiveness. In comparison to a typical absence seizure, changes in tone may be more pronounced, onset and/or cessation may be less abrupt, and the duration of the ictus and post-ictal recovery may be longer. Although not always available, an EEG often demonstrates slow (<3 Hz), irregular, generalized spike-wave activity.	SNOMEDCT_US:23374007|UMLS:C0595948	hp.json	Atypical petit mal seizures|Atypical absence|Atypical absence seizures	http://purl.obolibrary.org/obo/HP_0007270		
CHEBI:25697	biolink:ChemicalSubstance	organic cation	Any organic ion with a net positive charge.		hp.json	organic cations	http://purl.obolibrary.org/obo/CHEBI_25697		3_STAR
HP:0007271	biolink:PhenotypicFeature	Occipital myelomeningocele		UMLS:C4024912	hp.json		http://purl.obolibrary.org/obo/HP_0007271		
HP:0007272	biolink:PhenotypicFeature	Progressive psychomotor deterioration		UMLS:C1856565	hp.json	Progressive mental and motor deterioration	http://purl.obolibrary.org/obo/HP_0007272		
CHEBI:25696	biolink:ChemicalSubstance	organic anion	Any organic ion with a net negative charge.		hp.json	organic anions	http://purl.obolibrary.org/obo/CHEBI_25696		3_STAR
UBERON:0000457	biolink:AnatomicalEntity	cavernous artery	Any of several small branches of the internal carotid artery that supply the trigeminal ganglion and the walls of the cavernous and petrosal sinuses.	BTO:0002996|FMA:70527	hp.json	cavernous branch of cavernous part of internal carotid artery|ramus sinus cavernosi (pars cavernosa) (arteria carotis interna)	http://purl.obolibrary.org/obo/UBERON_0000457		
UBERON:0000458	biolink:AnatomicalEntity	endocervix	The region of the opening of the uterine cervix into the uterine cavity.	FMA:86485|BTO:0003002|NCIT:C12309|UMLS:C0227837	hp.json		http://purl.obolibrary.org/obo/UBERON_0000458		human_reference_atlas
UBERON:0000459	biolink:AnatomicalEntity	uterine wall	An anatomical wall that is part of a uterus [Automatically generated definition].	SCTID:245485002|FMA:17560|BTO:0003083	hp.json	anatomical wall of uterus|uterus anatomical wall|uterus wall|wall of uterus	http://purl.obolibrary.org/obo/UBERON_0000459		
HP:0032233	biolink:PhenotypicFeature	Increased circulating creatine kinase BB isoform	An increased concentration of the BB isoform of creatine kinase in the blood circulation.		hp.json	Increased circulating CK BB isoform	http://purl.obolibrary.org/obo/HP_0032233		
HP:0032234	biolink:PhenotypicFeature	Increased circulating creatine kinase MM isoform	An increased concentration of the MM isoform of creatine kinase in the blood circulation.		hp.json	Increased circulating CK MM isoform	http://purl.obolibrary.org/obo/HP_0032234		
HP:0032235	biolink:PhenotypicFeature	Anti-La/SS-B antibody positivity	The presence of autoantibodies in the blood circulation that react against La/SSB autoantigens.		hp.json		http://purl.obolibrary.org/obo/HP_0032235		
HP:0032236	biolink:PhenotypicFeature	Increased circulating immature neutrophil count	An abnormally increased number of immature neutrophils in the peripheral blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032236		
HP:0032230	biolink:PhenotypicFeature	Cytoplasmic antineutrophil antibody positivity	The presence of autoantibodies in the serum that react against proteins predominantly expressed in cytoplasmic granules of neutrophils.		hp.json	Anti-neutrophil cytoplasmic antibody positivity	http://purl.obolibrary.org/obo/HP_0032230		
HP:0032231	biolink:PhenotypicFeature	Hypochromia	A qualitative impression that red blood cells have less color than normal when examined under a microscope, usually related to a reduced amount of hemoglobin in the red blood cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032231		
CHEBI:25693	biolink:ChemicalSubstance	organic heteromonocyclic compound			hp.json	organic heteromonocyclic compounds	http://purl.obolibrary.org/obo/CHEBI_25693		3_STAR
HP:0032232	biolink:PhenotypicFeature	Increased circulating creatine kinase MB isoform	An increased concentration of the MB isoform of creatine kinase in the blood circulation.		hp.json	Increased circulating CK MB isoform	http://purl.obolibrary.org/obo/HP_0032232		
UBERON:0012437	biolink:AnatomicalEntity	epithelial-mesenchymal boundary	An anatomical line that adjacent_to a epithelium and adjacent_to a mesenchyme.		hp.json		http://purl.obolibrary.org/obo/UBERON_0012437		
CHEBI:62643	biolink:ChemicalSubstance	anionic phospholipid	Any organophosphate oxoanion that is a negatively charged phospholipid, e.g. phosphatidylserine(1-), phosphatidate(2-), phosphatidylglycerol(1-).		hp.json	anionic phospholipids|phospholipid anions|phospholipid anion	http://purl.obolibrary.org/obo/CHEBI_62643		3_STAR
HP:0032237	biolink:PhenotypicFeature	Increased circulating myelocyte count	An abnormally increased number of myelocytes in the peripheral blood circulation. Myelocytes are immature neutrophils with a size of 12-18 micrometers, a round or oval nucleus with no nucleoli, bluish-pink staining cytoplasm with primary and seconday granules, and a nucleus:cytoplasm ratio of 2:1.		hp.json		http://purl.obolibrary.org/obo/HP_0032237		
HP:0032238	biolink:PhenotypicFeature	Increased circulating metamyelocyte count	An abnormally increased number of metamyelocytes in the peripheral blood circulation. Metamyelocytes are immature neutrophils with a size of 10-18 micrometers, an indented or kidney-shaped nucleus, pinkish-blue staining cytoplasm with seconday granules, and a nucleus:cytoplasm ratio of 1.5:1.		hp.json		http://purl.obolibrary.org/obo/HP_0032238		
HP:0032239	biolink:PhenotypicFeature	Increased circulating band cell count	An abnormally increased number of band cells in the peripheral blood circulation. Band cells are immature neutrophils with a size of 10-18 micrometers, a horseshoe-shaped nucleus with no nucleoli, light-pink staining cytoplasm with many small seconday granules, and a nucleus:cytoplasm ratio of 1:2.		hp.json	Left shift|Increased circulating band form neutrophils	http://purl.obolibrary.org/obo/HP_0032239		
UBERON:0000464	biolink:AnatomicalEntity	anatomical space	Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures.	XAO:0003190|FMA:5897|UMLS:C0524461|HAO:0000005|NCIT:C94478|TAO:0001668|ZFA:0001643|VHOG:0001728|FBbt:00007017|EHDAA2:0003005|TGMA:0001825|BILA:0000005|CARO:0000005|AEO:0000005|AAO:0010110	hp.json	anatomical spaces|lumen space|lumen|space	http://purl.obolibrary.org/obo/UBERON_0000464		upper_level
HP:0007266	biolink:PhenotypicFeature	Cerebral dysmyelination	Defective structure and function of myelin sheaths of the white matter of the brain.	UMLS:C4020810|UMLS:C1854885	hp.json	Areas of dysmyelination on MRI|Dysmyelination of the brain|White matter dysmyelination/demyelination	http://purl.obolibrary.org/obo/HP_0007266		
UBERON:0000465	biolink:AnatomicalEntity	material anatomical entity	Anatomical entity that has mass.	VHOG:0001721|TAO:0001836|HAO:0000006|FMA:67165|EHDAA2:0003006|FBbt:00007016|BILA:0000006|TGMA:0001826|CARO:0000006|AEO:0000006|AAO:0010264	hp.json		http://purl.obolibrary.org/obo/UBERON_0000465		upper_level
HP:0007267	biolink:PhenotypicFeature	Chronic axonal neuropathy	An abnormality characterized by chronic impairment of the normal functioning of the axons.	UMLS:C4021578	hp.json	Chronic sural axonal neuropathy	http://purl.obolibrary.org/obo/HP_0007267		
HP:0007268	biolink:PhenotypicFeature	Aprosencephaly		MSH:D000757|SNOMEDCT_US:277922001|UMLS:C0431349	hp.json		http://purl.obolibrary.org/obo/HP_0007268		
UBERON:0000466	biolink:AnatomicalEntity	immaterial anatomical entity	Anatomical entity that has no mass.	HAO:0000007|TAO:0001835|FMA:67112|EHDAA2:0003007|VHOG:0001727|TGMA:0001827|FBbt:00007015|BILA:0000007|CARO:0000007|AEO:0000007|AAO:0010265	hp.json	immaterial physical anatomical entity	http://purl.obolibrary.org/obo/UBERON_0000466		upper_level
UBERON:0000467	biolink:AnatomicalEntity	anatomical system	Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function.	EV:0100000|ZFA:0001439|EHDAA2:0003011|EHDAA:392|BILA:0000011|TGMA:0001831|WBbt:0005763|galen:AnatomicalSystem|TAO:0001439|BIRNLEX:14|FBbt:00004856|CARO:0000011|AEO:0000011|SCTID:278195005|Wikipedia:Organ_system|OpenCyc:Mx4rCWM0QCtDEdyAAADggVbxzQ|EMAPA:16103|FMA:7149|MA:0000003|HAO:0000011|CALOHA:TS-2088|AAO:0000007|XAO:0003002|BSA:0000049|UMLS:C0460002|VHOG:0001725|NCIT:C12919|WBbt:0005746	hp.json	system|anatomical systems|connected anatomical system|organ system|body system	http://purl.obolibrary.org/obo/UBERON_0000467		uberon_slim|upper_level|pheno_slim
HP:0007269	biolink:PhenotypicFeature	Spinal muscular atrophy	Muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem.	MSH:D009134|UMLS:C0026847|SNOMEDCT_US:5262007	hp.json	Spinal muscle wasting|Spinal muscle degeneration	http://purl.obolibrary.org/obo/HP_0007269		
HP:0007262	biolink:PhenotypicFeature	Symmetric peripheral demyelination	A symmetric loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.	UMLS:C4024914	hp.json		http://purl.obolibrary.org/obo/HP_0007262		
HP:0007263	biolink:PhenotypicFeature	Spinocerebellar atrophy	Atrophy affecting the cerebellum and the spinocerebellar tracts of the spinal cord.	MSH:D020754|SNOMEDCT_US:129609000|UMLS:C0087012	hp.json		http://purl.obolibrary.org/obo/HP_0007263		
HP:0007265	biolink:PhenotypicFeature	Absent mesencephalon	Agenesis of the midbrain.	UMLS:C4024913	hp.json		http://purl.obolibrary.org/obo/HP_0007265		
UBERON:0000463	biolink:AnatomicalEntity	organism substance	Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body.	AAO:0010839|HAO:0000004|FMA:9669|EMAPA:35178|galen:BodySubstance|CALOHA:TS-2101|ZFA:0001487|FBbt:00007019|TAO:0001487|VHOG:0001726|NCIT:C13236|XAO:0004001|EHDAA2:0003004|MA:0002450|BILA:0000004|TGMA:0001824|SPD:0000008|AEO:0000004|CARO:0000004	hp.json	body substance|portion of body substance|body fluid or substance|organism substance|portion of organism substance	http://purl.obolibrary.org/obo/UBERON_0000463		upper_level|pheno_slim
HP:0007280	biolink:PhenotypicFeature	Acute infantile spinal muscular atrophy		UMLS:C4024911	hp.json		http://purl.obolibrary.org/obo/HP_0007280		
HP:0007281	biolink:PhenotypicFeature	Developmental stagnation	A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills.	UMLS:C1848980	hp.json	Developmental arrest	http://purl.obolibrary.org/obo/HP_0007281		
CHEBI:23045	biolink:ChemicalSubstance	carotenol			hp.json		http://purl.obolibrary.org/obo/CHEBI_23045		
GO:0001700	biolink:BiologicalProcess	embryonic development via the syncytial blastoderm	The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.		hp.json		http://purl.obolibrary.org/obo/GO_0001700		
UBERON:0000446	biolink:AnatomicalEntity	septum of telencephalon	Gray matter structure located on the midline of the forebrain consisting of the septum pellucidum (in some species) and the septal nuclei (Heimer, 1996).	BAMS:Sep|BAMS:SEP|BIRNLEX:963|UMLS:C0752060|BM:Tel-Spt|MA:0000924|BAMS:SA|BAMS:Spt|BTO:0002705|EMAPA:32837|FMA:61842|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=255	hp.json	area septalis|septum (NN)|septum pellucidum (BNA,PNA)|septal region|massa praecommissuralis|septal area|septum telencephali|septum|telencephalon septum|Se	http://purl.obolibrary.org/obo/UBERON_0000446		pheno_slim
CHEBI:50646	biolink:ChemicalSubstance	bone density conservation agent	An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.	Wikipedia:Osteoporosis	hp.json	anti-osteoporotics|bone density conservation drug|anti-osteoporosis drug|anti-osteopenia drug|bone density conservation agents|anti-osteoporotic drug|anti-osteoporosis agents|anti-osteopenia agents|anti-osteoporotic agents|antiosteoporotic|antiosteoporotics|anti-osteoporotic agent|anti-osteopenia agent|anti-osteoporosis agent|anti-osteoporotic drugs|anti-osteopenia drugs|anti-osteoporosis drugs|bone density conservation drugs|anti-osteoporotic	http://purl.obolibrary.org/obo/CHEBI_50646		3_STAR
HP:0032244	biolink:PhenotypicFeature	Decreased serum thromboxane B2	A reduction in the concentration of thromboxane B2 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032244		
UBERON:0012430	biolink:AnatomicalEntity	tunica fibrosa of eyeball	The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth.	FMA:58102|SCTID:361318005|Wikipedia:Fibrous_tunic_of_eyeball	hp.json	corneosclera|fibrous tunic|corneosclera|fibrous layer of eyeball|fibrous tunic|tunica fibrosa	http://purl.obolibrary.org/obo/UBERON_0012430		
HP:0032245	biolink:PhenotypicFeature	Abnormal metabolism	An abnormality in the function of the chemical reactions related to processes including conversion of food to enter, synthesis of proteins, lipids, nucleic acids, and carbohydrates, or the elimination of waste products.		hp.json		http://purl.obolibrary.org/obo/HP_0032245		
UBERON:0036422	biolink:AnatomicalEntity	wall of pulmonary artery		FMA:18211	hp.json	pulmonary arterial wall	http://purl.obolibrary.org/obo/UBERON_0036422		
HP:0032247	biolink:PhenotypicFeature	Persistent CMV viremia	Lasting (uncontrolled) presence of cytomegalovirus in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032247		
HP:0032240	biolink:PhenotypicFeature	Elevated circulating E selectin level	An increased concentration of E selectin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032240		
HP:0032241	biolink:PhenotypicFeature	Cervical neoplasm	A tumor (abnormal growth of tissue) of the uterine cervix.		hp.json		http://purl.obolibrary.org/obo/HP_0032241		
CHEBI:23044	biolink:ChemicalSubstance	carotenoid			hp.json		http://purl.obolibrary.org/obo/CHEBI_23044		
HP:0032242	biolink:PhenotypicFeature	Cervical intraepithelial neoplasia	A precancerous condition characterized by dysplasia of the cervical epithelium. Cervical intraepithelial neoplasia (CIN) 1, 2 and 3 based on its relationship with the prognosis. CIN 1 is mild dysplasia, which is mostly observed because it disappears as part of its natural course. CIN 3 includes severe dysplasia and carcinoma in situ, and management involves treatment because it is highly likely to develop into invasive cancer.		hp.json		http://purl.obolibrary.org/obo/HP_0032242		
HP:0032243	biolink:PhenotypicFeature	Abnormal tissue metabolite concentration	Any deviation from the normal concentration of a metabolite in a tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0032243		
UBERON:0012425	biolink:AnatomicalEntity	striated border microvillus layer	A microvillus layer that is striated and found in the intestine.	FMA:70978|NCIT:C33634	hp.json	striated border	http://purl.obolibrary.org/obo/UBERON_0012425		
HP:0032248	biolink:PhenotypicFeature	Persistent viremia	Persistence of virus in the blood circulation longer than would be normal in an immunocompentent host.		hp.json		http://purl.obolibrary.org/obo/HP_0032248		
HP:0032249	biolink:PhenotypicFeature	Coccidioidomycosis	Infection by a Coccidioides species fungus. These are dimorphic, soil-dwelling, fungi known to cause a broad spectrum of disease, ranging from a mild febrile illness to severe pulmonary manifestations or disseminated disease. The genus Coccidioides is comprised of two genetically distinct species: Coccidioides immitis and C. posadasii.		hp.json	Valley fever	http://purl.obolibrary.org/obo/HP_0032249		
UBERON:0012429	biolink:AnatomicalEntity	hematopoietic tissue	Blood-forming tissue, consisting of reticular fibers and cells.	UMLS:C0229619|CALOHA:TS-2142|FMA:14073|NCIT:C13051	hp.json	hemopoietic tissue|haemopoietic tissue|hematopoietic tissue|bone marrow tissue|textus haemopoieticus	http://purl.obolibrary.org/obo/UBERON_0012429		
HP:0007277	biolink:PhenotypicFeature	Paucity of anterior horn motor neurons		UMLS:C2673351	hp.json		http://purl.obolibrary.org/obo/HP_0007277		
GO:0001705	biolink:BiologicalProcess	ectoderm formation	The formation of ectoderm during gastrulation.		hp.json		http://purl.obolibrary.org/obo/GO_0001705		
UBERON:0000454	biolink:AnatomicalEntity	cerebral subcortex	The layer located below the cerebral cortex that includes the forebrain, midbrain and hindbrain.	FMA:242188|NCIT:C98712|UMLS:C0815008|BTO:0002858	hp.json	subcortex|cerebral medulla	http://purl.obolibrary.org/obo/UBERON_0000454		pheno_slim
GO:0001706	biolink:BiologicalProcess	endoderm formation	The formation of the endoderm during gastrulation.		hp.json	endoblast formation	http://purl.obolibrary.org/obo/GO_0001706		
GO:0001707	biolink:BiologicalProcess	mesoderm formation	The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.		hp.json		http://purl.obolibrary.org/obo/GO_0001707		
UBERON:0000456	biolink:AnatomicalEntity	secretion of exocrine gland	A portion of organism substance that is produced by exocrine glands.	AEO:0001005|EMAPA:36535|NCIT:C34062|MA:0002504|UMLS:C1516992|MESH:D012634|BTO:0002979|FMA:9675|BTO:0002977|galen:Secretion	hp.json	external secretion|exocrine gland fluid or secretion|secretion|secreted substance|exocrine gland fluid|bodily secretion|exocrine gland fluid/secretion|exocrine gland secretion	http://purl.obolibrary.org/obo/UBERON_0000456		
CHEBI:37684	biolink:ChemicalSubstance	mannose	An aldohexose that is the C-2 epimer of glucose.	PMID:16180318|PMID:24407290	hp.json	mannose|Man|manno-hexose	http://purl.obolibrary.org/obo/CHEBI_37684		3_STAR
GO:0001701	biolink:BiologicalProcess	in utero embryonic development	The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.		hp.json		http://purl.obolibrary.org/obo/GO_0001701		
HP:0007274	biolink:PhenotypicFeature	Recurrent bacterial meningitis	An increased susceptibility to bacterial meningitis as manifested by a medical history of recurrent episodes of bacterial meningitis.	UMLS:C1845604	hp.json		http://purl.obolibrary.org/obo/HP_0007274		
GO:0001704	biolink:BiologicalProcess	formation of primary germ layer	The formation of the ectoderm, mesoderm and endoderm during gastrulation.		hp.json		http://purl.obolibrary.org/obo/GO_0001704		
UBERON:0000439	biolink:AnatomicalEntity	arachnoid trabecula	The arachnoid trabeculae are delicate strands of connective tissue that loosely connect the two innermost layers of the meninges -- the arachnoid mater and the pia mater. They are found within the subarachnoid space where cerebrospinal fluid is also found. Embryologically, the trabeculae are the remnants of the common precursor that forms both the arachnoid and pial layers of the meninges.	BTO:0002500|FMA:83979	hp.json	trabecula arachnoideum|arachnoid trabeculae	http://purl.obolibrary.org/obo/UBERON_0000439		
CHEBI:23014	biolink:ChemicalSubstance	carbon oxide			hp.json	carbon oxides|oxides of carbon	http://purl.obolibrary.org/obo/CHEBI_23014		3_STAR
CHEBI:25676	biolink:ChemicalSubstance	oligopeptide	A peptide containing a relatively small number of amino acids.	Wikipedia:Oligopeptide	hp.json	Oligopeptid|oligopeptides|oligopeptido	http://purl.obolibrary.org/obo/CHEBI_25676		3_STAR
HP:0032250	biolink:PhenotypicFeature	Acinetobacter infection	An infection by Acinetobacter baumannii, a Gram-negative bacillus that is aerobic, pleomorphic and non-motile. An opportunistic pathogen, A. baumannii has a high incidence among immunocompromised individuals, particularly those who have experienced a prolonged (over 90 d) hospital stay.		hp.json		http://purl.obolibrary.org/obo/HP_0032250		
HP:0007250	biolink:PhenotypicFeature	Recurrent external ophthalmoplegia	Alternating and recurrent weakness of the external ocular muscles.	UMLS:C4024915	hp.json		http://purl.obolibrary.org/obo/HP_0007250		
CHEBI:23019	biolink:ChemicalSubstance	carbonyl group			hp.json	>C=O|carbonyl group|carbonyl group|carbonyl	http://purl.obolibrary.org/obo/CHEBI_23019		3_STAR
HP:0032255	biolink:PhenotypicFeature	Opportunistic fungal infection	An infection that is caused by a fungus that would generally not be able to cause an infection in a host with a normal immune system. Such fungi take advantage of the opportunity, so to speak, that is provided by a weakened immune system.		hp.json		http://purl.obolibrary.org/obo/HP_0032255		
HP:0032256	biolink:PhenotypicFeature	Histoplasmosis	Histoplasmosis is caused by the fungus Histoplasma capsulatum and is consider to be an opportunistic infection in immunosuppressed persons.		hp.json		http://purl.obolibrary.org/obo/HP_0032256		
HP:0032257	biolink:PhenotypicFeature	Disseminated histoplasmosis	Histoplasmosis infection involving multiple sites of the body. Disseminated histoplasmosis can involve various organs, including reticuloendothelial organs, gastrointestinal tract, adrenal glands, central nervous system, endovascular structures, kidney, and skin. It typically presents with systemic symptoms like fever, generalized fatigue, night sweats, weight loss, and the symptoms related to the specific organ involved. Severe disseminated disease can manifest as septic shock, multi organ failure, and ARDS.		hp.json		http://purl.obolibrary.org/obo/HP_0032257		
HP:0032258	biolink:PhenotypicFeature	Pulmonary histoplasmosis	Infection of the lungs with Histoplasma capsulatum. Symptoms may include fever, headache, weakness, chest pain and dry cough. When imaging is done, chest radiographs may show patchy pneumonia involving one or more lobes with adenopathy of the mediastinum or hilum.		hp.json		http://purl.obolibrary.org/obo/HP_0032258		
HP:0032251	biolink:PhenotypicFeature	Abnormal immune system morphology			hp.json		http://purl.obolibrary.org/obo/HP_0032251		
UBERON:0012423	biolink:AnatomicalEntity	layer of microvilli	A layer of microvilli, Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments[GO,modified].	NCIT:C33112|UMLS:C0026049|MESH:D008871|FMA:67296	hp.json	microvilli|microvillus	http://purl.obolibrary.org/obo/UBERON_0012423		
HP:0032252	biolink:PhenotypicFeature	Granuloma	A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.		hp.json		http://purl.obolibrary.org/obo/HP_0032252		
HP:0032253	biolink:PhenotypicFeature	Eosinophilic granuloma	A type of granuloma characterized morphologically by the predominance of Langerhans cells with characteristic grooved, folded, indented nuclei in the appropriate milieu that includes variable numbers of eosinophils and histiocytes including multinucleated forms, often appearing similar to osteoclasts or touton like giant cells, neutrophils and small lymphocytes. The concentration of the eosinophilic infiltrate varies from scattered mature cells to sheet-like masses of cells. Occasionally, areas of bone necrosis may interrupt the cellular infiltrate. The foamy cells may also be amassed in clumps, which are of no clinical significance because these clumps represent phagocytosis of lipid debris.		hp.json		http://purl.obolibrary.org/obo/HP_0032253		
HP:0032254	biolink:PhenotypicFeature	Increased circulating copper concentration	An abnormally elevated concentration of copper in the blood circulation. This term refers to the total copper concentration.		hp.json	Elevated serum copper|Hypercupremia	http://purl.obolibrary.org/obo/HP_0032254		
UBERON:0012416	biolink:AnatomicalEntity	respiratory system arterial smooth muscle		EMAPA:37567|MA:0001802	hp.json		http://purl.obolibrary.org/obo/UBERON_0012416		human_reference_atlas
CHEBI:60004	biolink:ChemicalSubstance	mixture	A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind.		hp.json	Mischung	http://purl.obolibrary.org/obo/CHEBI_60004		3_STAR
HP:0032259	biolink:PhenotypicFeature	Chronic tinea infection	The term tinea means fungal infection, whereas dermatophyte refers to the fungal organisms that cause tinea. This term refers to a tinea infection that is chronic or recalcitrant to treatment and may be reflective of an immune defect.		hp.json		http://purl.obolibrary.org/obo/HP_0032259		
HP:0007249	biolink:PhenotypicFeature	Decreased number of small peripheral myelinated nerve fibers		UMLS:C4024916	hp.json	Decreased number of small peripheral myelinated nerve fibres	http://purl.obolibrary.org/obo/HP_0007249		
UBERON:0012418	biolink:AnatomicalEntity	respiratory system venous smooth muscle	A smooth muscle tissue that is part of a respiratory system venous blood vessel.	EMAPA:37586|MA:0001812	hp.json		http://purl.obolibrary.org/obo/UBERON_0012418		human_reference_atlas
UBERON:0000442	biolink:AnatomicalEntity	right testicular vein	A vein that drains the left pampiniform plexus and empties into the left renal vein.	MA:0002220|EMAPA:37383|NCIT:C52697|FMA:14341|BTO:0002679	hp.json	vena testicularis dextra|vena testicularis sinistra|right spermatic vein|vena testicularis (adrenalis) dextra	http://purl.obolibrary.org/obo/UBERON_0000442		human_reference_atlas
HP:0020222	biolink:PhenotypicFeature	Hypohomocysteinemia	A decreased concentration of homocystine in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0020222		
UBERON:0000443	biolink:AnatomicalEntity	left testicular vein	A vein that drains the right pampiniform plexus and empties into the inferior vena cava.	EMAPA:37167|MA:0002219|FMA:14345|BTO:0002680|NCIT:C52696	hp.json	vena testicularis dextra|vena testicularis sinistra|left spermatic vein	http://purl.obolibrary.org/obo/UBERON_0000443		human_reference_atlas
HP:0020221	biolink:PhenotypicFeature	Clonic seizure	A clonic seizure is a type of motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive.		hp.json		http://purl.obolibrary.org/obo/HP_0020221		
UBERON:0000444	biolink:AnatomicalEntity	lymphoid follicle		BTO:0002684|NCIT:C33040|FMA:55222|UMLS:C0229654	hp.json	nodulus lymphaticus|folliculus lymphaticus|lymphoid nodule|nodulus lymphoideus|lymphatic follicle|lymphatic nodule|nodular lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0000444		
HP:0020223	biolink:PhenotypicFeature	Dermal sinus tract	A dermal sinus tract is an abnormality present at birth over the dorsal midline where an abnormal epithelialized connection from the skin tracks inwards towards the spine, most commonly seen in the lumbosacral region.		hp.json		http://purl.obolibrary.org/obo/HP_0020223		
HP:0007240	biolink:PhenotypicFeature	Progressive gait ataxia	A type of gait ataxia displaying progression of clinical severity.	UMLS:C1843885	hp.json	Gait ataxia, progressive	http://purl.obolibrary.org/obo/HP_0007240		
HP:0020220	biolink:PhenotypicFeature	Focal atonic seizure	A focal seizure characterized at onset by sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic activity, typically lasting more than 500 ms but less than 2 seconds. It may involve the head, trunk, jaw or limb musculature.		hp.json	Segmental atonic seizure|Partial hypotonic seizure|Segmental hypotonic seizure|Partial atonic seizure|Localized hypotonic seizure|Localised atonic seizure|Localized atonic seizure|Localised hypotonic seizure	http://purl.obolibrary.org/obo/HP_0020220		
UBERON:0000440	biolink:AnatomicalEntity	trabecula	A small, often microscopic, tissue element in the form of a small beam, strut or rod, generally having a mechanical function, and usually but not necessarily composed of dense collagenous tissue. On histological section, a trabecula can look like a septum, but in three dimensions they are topologically distinct, with trabeculae being roughly rod or pillar-shaped and septa being sheet-like. Trabeculae are usually composed of dense fibrous tissue, i.e. mainly of collagen, and in most cases provide mechanical strengthening or stiffening to a soft solid organ, such as the spleen. They can be composed of other materials, such as bone or muscle[WP].	BTO:0002501|FMA:85273	hp.json	trabeculae	http://purl.obolibrary.org/obo/UBERON_0000440		grouping_class|pheno_slim
HP:0020219	biolink:PhenotypicFeature	Motor seizure	A motor seizure is a type of seizure that is characterized at onset by involvement of the skeletal musculature. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement.		hp.json		http://purl.obolibrary.org/obo/HP_0020219		
UBERON:0000428	biolink:AnatomicalEntity	prostate epithelium	The prostate epithelium.	CALOHA:TS-2065|NCIT:C13103|FMA:66812|EMAPA:35711|MA:0001737|FMA:79643|UMLS:C1179826|BTO:0002397	hp.json	prostate epithelial tissue|prostatic gland epithelium|epithelium of prostatic gland|epithelial tissue of prostate gland|epithelial tissue of prostate|epithelium of prostate gland|prostatic epithelium|epithelium of prostate|prostate gland epithelium|prostate gland epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0000428		pheno_slim|human_reference_atlas
UBERON:0000429	biolink:AnatomicalEntity	enteric plexus	A plexus of autonomic nerve fibers within the wall of the digestive tube, and made up of the submucosal, myenteric, and subserosal plexuses; it contains visceral afferent fibers, sympathetic postganglionic fibers, parasympathetic preganglionic and postganglionic fibers, and parasympathetic postganglionic cell bodies.	MA:0001147|BTO:0002437|EMAPA:35446|FMA:77597	hp.json	enteric nerve plexus|sympathetic enteric nerve plexus|plexus entericus|plexus nervosus entericus|intrinsic nerve plexus	http://purl.obolibrary.org/obo/UBERON_0000429		
HP:0020218	biolink:PhenotypicFeature	Focal aware atonic seizure	A type of focal atonic seizure during which awareness is fully retained throughout.		hp.json		http://purl.obolibrary.org/obo/HP_0020218		
HP:0007260	biolink:PhenotypicFeature	Type II lissencephaly	A form of lissencephaly characterized by an uneven cortical surface with a so called 'cobblestone' appearace. There are no distinguishable cortical layers.	MSH:D054222|UMLS:C0431376|SNOMEDCT_US:253149002	hp.json	Lissencephaly type II|Cobblestone lissencephaly|Type 2 lissencephaly	http://purl.obolibrary.org/obo/HP_0007260		
HP:0032260	biolink:PhenotypicFeature	Opportunistic bacterial infection	An infection that is caused by a bacterium that would generally not be able to cause an infection in a host with a normal immune system. Such bacteria take advantage of the opportunity, so to speak, that is provided by a weakened immune system.		hp.json		http://purl.obolibrary.org/obo/HP_0032260		
HP:0032261	biolink:PhenotypicFeature	Nontuberculous mycobacterial pulmonary infection	An infection of the lung caused by environmental mycobacteria. Such infections can occur in individuals with predisposing lung disease or immune disease.		hp.json		http://purl.obolibrary.org/obo/HP_0032261		
CHEBI:49637	biolink:ChemicalSubstance	hydrogen atom		WebElements:H	hp.json	H|1H|Wasserstoff|hydrogene|hydrogen|hydrogen|hidrogeno	http://purl.obolibrary.org/obo/CHEBI_49637		3_STAR
HP:0020215	biolink:PhenotypicFeature	Thinking-induced seizure	Seizures induced by thinking and decision-making. comment:		hp.json	Cognition induced seizure	http://purl.obolibrary.org/obo/HP_0020215		
HP:0020214	biolink:PhenotypicFeature	Startle-induced seizure	Startle-induced seizures are triggered by multiple and non-specific stimuli (auditory, somatosensory, and rarely visual) and are characterized by their sudden unexpected nature. Sudden noise rather than pure sound is the most effective acoustic stimulus.		hp.json		http://purl.obolibrary.org/obo/HP_0020214		
HP:0020217	biolink:PhenotypicFeature	Focal aware motor seizure	A type of focal motor seizure in which awareness is retained throughout the seizure.		hp.json	Focal motor aware seizure	http://purl.obolibrary.org/obo/HP_0020217		
HP:0020216	biolink:PhenotypicFeature	Visually-induced seizure	Seizures evoked by visual stimuli. This includes clinical seizures induced by strobe lighting, television and other screens, flickering environmental lighting and self-induction by causing a strobe effect.		hp.json	Photosensitive seizure	http://purl.obolibrary.org/obo/HP_0020216		
HP:0032266	biolink:PhenotypicFeature	CSF anti-NMDA receptor antibody positivity	The presence of autoantibodies (immunoglobulins) in the cerebrospinal fluid (CSF) that react against the NMDA (N-methyl-D-aspartate)-type glutamate receptor.		hp.json	Presence of NMDAR antibody in CSF|Presence of anti-N-methyl-D-aspartate Receptor antibody in CSF|Presence of anti-NMDAR antibody in cerebrospinal fluid	http://purl.obolibrary.org/obo/HP_0032266		
HP:0010896	biolink:PhenotypicFeature	Hypersarcosinemia	An elevated plasma concentration of sarcosine.	SNOMEDCT_US:64852002|MSH:C537236|UMLS:C0268563	hp.json	High plasma sarcosine levels	http://purl.obolibrary.org/obo/HP_0010896		
HP:0010895	biolink:PhenotypicFeature	Abnormal circulating glycine concentration	Any deviation from the normal concentration of glycine in the blood circulation.	UMLS:C4023670	hp.json		http://purl.obolibrary.org/obo/HP_0010895		
UBERON:0036441	biolink:AnatomicalEntity	wall of uterine tube		FMA:18303	hp.json	wall of fallopian tube|uterine tube wall|wall of oviduct	http://purl.obolibrary.org/obo/UBERON_0036441		
HP:0032267	biolink:PhenotypicFeature	Empty delta sign	This sign is created by a nonenhancing thrombus in the dural sinus surrounded by triangular enhancing dura as seen on cross-section. The sign, seen on contrast-enhanced CT scan images, suggests dural sinovenous thrombosis. It is best seen on wider window settings. It is a reliable sign of sinus thrombosis but is seen only in 25-30% of these cases.		hp.json		http://purl.obolibrary.org/obo/HP_0032267		
HP:0032268	biolink:PhenotypicFeature	Dural tail sign	This sign represents thickening and enhancement of the dura mater in continuity with a mass, which on MR images, gives the appearance of a tail arising from the mass. The dural tail is thought to represent reactive change; however, it may also be due to tumor invasion. Three criteria need to be met for a positive dural tail sign: the tail should be seen on two successive images through the tumor, it should taper away from the tumor, and it must enhance more than the tumor.		hp.json		http://purl.obolibrary.org/obo/HP_0032268		
HP:0010894	biolink:PhenotypicFeature	Abnormal circulating serine family amino acid concentration	Any deviation from the normal concentration of a serine family amino acid in the blood circulation.	UMLS:C4023671	hp.json	Abnormality of serine family amino acid metabolism	http://purl.obolibrary.org/obo/HP_0010894		
HP:0032269	biolink:PhenotypicFeature	Lemon sign	The lemon sign refers to the shape of the fetal skull at ultrasonography (US) when the frontal bones lose their normal convex contour and appear flattened or inwardly scalloped. This gives the skull a shape that is said to resemble a lemon.. The sign is seen on transverse sonograms of the fetal cranium obtained at the level of the ventricles.		hp.json		http://purl.obolibrary.org/obo/HP_0032269		
HP:0010893	biolink:PhenotypicFeature	Abnormal circulating phenylalanine concentration	Any deviation from the normal concentration of phenylalanine in the blood circulation.	UMLS:C4023672	hp.json	Abnormality of phenylalanine metabolism	http://purl.obolibrary.org/obo/HP_0010893		
HP:0032262	biolink:PhenotypicFeature	Pulmonary tuberculosis	A lung infection by Mycobacterium tuberculosis a slightly curved non-motile, aerobic, non-capsulated and non-spore forming strains of mycobacteria.		hp.json	Pulmonary TB	http://purl.obolibrary.org/obo/HP_0032262		
HP:0010892	biolink:PhenotypicFeature	Abnormal circulating branched chain amino acid concentration	Any deviation from the normal concentration of a branched chain family amino acid in the blood circulation.	UMLS:C4023673	hp.json		http://purl.obolibrary.org/obo/HP_0010892		
HP:0010891	biolink:PhenotypicFeature	Morbus Scheuermann	A developmental growth retardation of the vertebral end plates that may lead to secondary destruction of the vertebral end plates and protrusion of the nucleus pulposus into the vertebral body (so called Schmorl's nodes as seen on x-rays).	MSH:D012544|SNOMEDCT_US:53406005|UMLS:C0036310	hp.json	Sherman's Disease|Scheuermann kyphosis|Calve disease|Scheuermann disease|Juvenile osteochondrosis of the spine	http://purl.obolibrary.org/obo/HP_0010891		
HP:0032263	biolink:PhenotypicFeature	Increased blood pressure	Abnormal increase in blood pressure. An individual measurement of increased blood pressure does not necessarily imply hypertension. In practical terms, multiple measurements are recommended to diagnose the presence of hypertension.		hp.json	Increased BP	http://purl.obolibrary.org/obo/HP_0032263		
HP:0032264	biolink:PhenotypicFeature	Anti-NMDA receptor antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against the NMDA (N-methyl-D-aspartate)-type glutamate receptor.		hp.json	Presence of anti-NMDAR antibody in blood|Presence of anti-N-methyl-D-aspartate Receptor antibody in blood	http://purl.obolibrary.org/obo/HP_0032264		
HP:0010890	biolink:PhenotypicFeature	Morbus Osgood-Schlatter	Morbus Osgood-Schlatter is a Juvenile aseptic necrosis affecting the Tuberositas tibiae.	MSH:D055034|SNOMEDCT_US:79353000|SNOMEDCT_US:72047008|UMLS:C0029376	hp.json	Osgood Schlatter disease	http://purl.obolibrary.org/obo/HP_0010890		
HP:0032265	biolink:PhenotypicFeature	CSF autoimmune antibody positivity	The presence of an antibody in the cerebrospinal fluid (CSF) that is directed against the organism's own cells or tissues.		hp.json	Cerebrospinal fluid autoimmune antibody positivity	http://purl.obolibrary.org/obo/HP_0032265		
HP:0010899	biolink:PhenotypicFeature	Abnormal circulating aspartate family amino acid concentration	Any deviation from the normal concentration of an aspartate family amino acid in the blood circulation.	UMLS:C4023667	hp.json		http://purl.obolibrary.org/obo/HP_0010899		
HP:0010898	biolink:PhenotypicFeature	Abnormal circulating sarcosine concentration	An deviation from the normal concentration of sarcosine in the blood circulation.	UMLS:C4023668	hp.json		http://purl.obolibrary.org/obo/HP_0010898		
HP:0010897	biolink:PhenotypicFeature	Hypersarcosinuria	An elevated urinary concentration of sarcosine.	UMLS:C4023669	hp.json	High urine sarcosine levels	http://purl.obolibrary.org/obo/HP_0010897		
HP:0020211	biolink:PhenotypicFeature	Proprioceptive-induced seizure	A seizure precipitated by movement or a change in posture.		hp.json		http://purl.obolibrary.org/obo/HP_0020211		
HP:0020210	biolink:PhenotypicFeature	Praxis-induced seizure	A seizure precipitated by complex, cognition-guided tasks often involving visuomotor coordination and decision-making.		hp.json		http://purl.obolibrary.org/obo/HP_0020210		
HP:0007256	biolink:PhenotypicFeature	Abnormal pyramidal sign	Functional neurological abnormalities related to dysfunction of the pyramidal tract.	UMLS:C0234132|SNOMEDCT_US:14648003	hp.json	Pyramidal tract signs|Pyramidal signs|Corticospinal signs	http://purl.obolibrary.org/obo/HP_0007256		
HP:0020213	biolink:PhenotypicFeature	Somatosensory-induced seizure	A somatosensory reflex seizure is a seizure precipitated by somatic stimulation of a specific part of the body in the absence of startle or surprise.		hp.json		http://purl.obolibrary.org/obo/HP_0020213		
HP:0020212	biolink:PhenotypicFeature	Reading-induced seizure	A seizure precipitated by reading.		hp.json		http://purl.obolibrary.org/obo/HP_0020212		
HP:0007258	biolink:PhenotypicFeature	Severe demyelination of the white matter	A severe loss of myelin from nerve fibers in the central nervous system.	UMLS:C1856001	hp.json		http://purl.obolibrary.org/obo/HP_0007258		
CHEBI:37661	biolink:ChemicalSubstance	glucopyranose			hp.json	glucopyranose	http://purl.obolibrary.org/obo/CHEBI_37661		3_STAR
UBERON:0012482	biolink:AnatomicalEntity	submucosa of cloaca	A submucosa that is part of a cloaca [Automatically generated definition].		hp.json	cloaca submucosa|cloacal submucosa	http://purl.obolibrary.org/obo/UBERON_0012482		
UBERON:0012481	biolink:AnatomicalEntity	cloacal epithelium	An epithelium that is part of a cloaca.	ZFA:0005783|EMAPA:36070|EMAPA:27577	hp.json	cloacal endoderm	http://purl.obolibrary.org/obo/UBERON_0012481		
UBERON:0012480	biolink:AnatomicalEntity	cloacal mucosa	A mucosa that is part of a cloaca [Automatically generated definition].		hp.json	cloaca mucous membrane|cloaca mucosa|cloaca organ mucosa|mucosa of organ of cloaca|cloacal mucous membrane|mucosa of cloaca|organ mucosa of cloaca|mucous membrane of cloaca|cloaca mucosa of organ	http://purl.obolibrary.org/obo/UBERON_0012480		
UBERON:0012486	biolink:AnatomicalEntity	muscle layer of cloaca	A muscular coat that is part of a cloaca.		hp.json	smooth muscle of cloaca|muscularis externa of cloaca	http://purl.obolibrary.org/obo/UBERON_0012486		
UBERON:0012485	biolink:AnatomicalEntity	cloacal villus			hp.json	cloacal villi	http://purl.obolibrary.org/obo/UBERON_0012485		
UBERON:0012483	biolink:AnatomicalEntity	serosa of cloaca	A serous membrane that is part of a cloaca [Automatically generated definition].		hp.json	cloaca serous membrane|visceral peritoneum of cloaca|cloacal serosa|serous membrane of cloaca|cloaca serosa	http://purl.obolibrary.org/obo/UBERON_0012483		
UBERON:0012489	biolink:AnatomicalEntity	muscle layer of colon	A muscular coat that is part of a colon.	EMAPA:27383|MA:0003198|FMA:14986|SCTID:362158003	hp.json	colon muscularis|tunica muscularis coli|muscularis externa of colon|colonic muscularis propria|muscular coat of colon|muscular layer of colon	http://purl.obolibrary.org/obo/UBERON_0012489		human_reference_atlas
UBERON:0012488	biolink:AnatomicalEntity	muscle layer of duodenum	A muscular coat that is part of a duodenum.	FMA:14944	hp.json	muscularis externa of duodenum|smooth muscle of duodenum|muscularis propria of duodenum|duodenal muscularis propria	http://purl.obolibrary.org/obo/UBERON_0012488		
UBERON:0012487	biolink:AnatomicalEntity	vaginal sphincter	A sphincter muscle that is part of a vagina.		hp.json	sphincter of vagina	http://purl.obolibrary.org/obo/UBERON_0012487		
CHEBI:60027	biolink:ChemicalSubstance	polymer	A polymer is a mixture, which is composed of macromolecules of different kinds and which may be differentiated by composition, length, degree of branching etc..	Wikipedia:Polymer	hp.json	Kunststoff|Polymer	http://purl.obolibrary.org/obo/CHEBI_60027		3_STAR
CHEBI:37631	biolink:ChemicalSubstance	beta-L-glucose	A L-glucopyranose with a beta-configuration at the anomeric position.	Reaxys:1907373|Beilstein:1907373|GlyTouCan:G59396XU|GlyGen:G59396XU	hp.json	WURCS=2.0/1,1,0/[a1211h-1b_1-5]/1/|beta-L-glucopyranose	http://purl.obolibrary.org/obo/CHEBI_37631		3_STAR
CHEBI:23004	biolink:ChemicalSubstance	carbamoyl group	The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid.	PMID:24168430	hp.json	carboxamide|-CONH2|aminocarbonyl|carbamyl|carbamyl group|-C(O)NH2|carbamoyl	http://purl.obolibrary.org/obo/CHEBI_23004		3_STAR
UBERON:0012475	biolink:AnatomicalEntity	skeleton of pectoral complex	The collection of all skeletal elements in a pectoral complex - i.e. the combination of free limb or fin plus pectoral girdle.	FMA:24139	hp.json	bones of upper limb|pectoral complex skeleton|ossa membri superioris|skeleton of anterior limb/fin and girdle|upper limb skeleton|set of bones of upper limb	http://purl.obolibrary.org/obo/UBERON_0012475		pheno_slim
HP:0032200	biolink:PhenotypicFeature	Perivascular fibrosis	The presence of thick collagen bundles around blood vessels, often in an onion-skin type whorling pattern.		hp.json		http://purl.obolibrary.org/obo/HP_0032200		
HP:0032201	biolink:PhenotypicFeature	Rotator cuff tear	The term rotator cuff describes the tendons connecting the infraspinatus, supraspinatus, teres minor, and subscapularis muscles to the humeral head.Traumatic tears of the rotator cuff tend to occur at the tendon-bone junction of the supraspinatus and greater tuberosity of the humerus whereas degenerative tears tend to be seen posteriorly at the junction of the supraspinatus and infraspinatu A rotator cuff tear is when one or more of these tendons tears or detaches from the humerus.		hp.json		http://purl.obolibrary.org/obo/HP_0032201		
HP:0032202	biolink:PhenotypicFeature	Vulvar intraepithelial neoplasia	Vulvar intraepithelial neoplasia (VIN) is widely accepted as the precursor lesion of vulvar squamous cell carcinoma (VSCC). VSCC arises via either a human papilloma virus (HPV)-associated pathway, or more commonly, via a mechanism independent of HPV, often being linked to chronic inflammatory conditions such as lichen sclerosus (LS). Accordingly, two distinct subtypes of VIN are recognised: the HPV-associated high-grade squamous intraepithelial lesion/usual VIN (HSIL/uVIN) and the non-HPV-associated differentiated VIN (dVIN). HSIL is clinically identified by its multifocal, warty appearance and on histology by conspicuous cytological and architectural atypia. Differentiated VIN, on the other hand, often produces ill-defined lesions, and on histology, notoriously mimics non-neoplastic epithelial disorders (NNED), particularly LS. As a result, dVIN is rarely identified in advance of a diagnosis of invasive malignancy, despite being the precursor lesion of the majority of VSCC.		hp.json		http://purl.obolibrary.org/obo/HP_0032202		
HP:0032203	biolink:PhenotypicFeature	Lymphoid nodular hyperplasia	Lymphoid nodular hyperplasia (LNH) of the terminal ileum and colon has been considered a mucosal response to nonspecific stimuli, most often infections, and consequently has been regarded as a pathophysiologic phenomenon during infancy and childhood. LNH can be ascertained by colonoscopy, whereby a lymphoid nodule is defined as an extruding follicle with a diameter of not more than 2 mm, and LNH is defined as a cluster of not more than 10 of such extruding lymphoid nodules (see Figure 1 of PMID:17368236).		hp.json	Lymphonodular hyperplasia of the colon	http://purl.obolibrary.org/obo/HP_0032203		
UBERON:0012478	biolink:AnatomicalEntity	cloacal gland	A gland that is part of a cloaca.		hp.json		http://purl.obolibrary.org/obo/UBERON_0012478		
UBERON:0012477	biolink:AnatomicalEntity	dorsal part of neck	The posterior region of the neck, including the suboccipital region.	FMA:24189|BTO:0000957	hp.json	back of neck|nape|hindneck|nape of neck|regio cervicalis posterior|nuchal region|posterior part of neck|posterior cervical region|neck back|nucha|posterior neck region	http://purl.obolibrary.org/obo/UBERON_0012477		pheno_slim
UBERON:0012476	biolink:AnatomicalEntity	skeleton of pelvic complex	The collection of all skeletal elements in a pelvic complex - i.e. the combination of free limb or fin plus pelvic girdle.	FMA:24140	hp.json	pelvic complex skeleton|set of bones of lower limb|skeleton of posterior limb/fin and girdle|lower limb skeleton|bones of lower limb|pelvic complex skeleton|ossa membri inferioris|skeleton of posterior limb/fin and girdle	http://purl.obolibrary.org/obo/UBERON_0012476		pheno_slim
HP:0032208	biolink:PhenotypicFeature	Increased urinary type 1 collagen N-terminal telopeptide level	An increased concentration of type 1 collagen N-terminal telopeptide (NTx) level in the urine. Generally the test is performed over a period of time, for instance, 10 cc of morning urine can be collected following 12 hours overnight fasting or for 24 hours.		hp.json	Increased urine NTx level|Increased collagen crosslinked N-telopeptide [Moles/volume] in 24 hour urine	http://purl.obolibrary.org/obo/HP_0032208		
UBERON:0000490	biolink:AnatomicalEntity	unilaminar epithelium	Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA].	BTO:0002073|CARO:0000073|AEO:0000073|NCIT:C33554|ZFA:0001495|UMLS:C0682574|HAO:0000073|TAO:0001495|SCTID:309043004|AAO:0010062|EHDAA2:0003073|XAO:0004007|FMA:45561|BILA:0000073	hp.json	simple epithelium|unilaminar epithelia	http://purl.obolibrary.org/obo/UBERON_0000490		vertebrate_core
HP:0032209	biolink:PhenotypicFeature	Abnormal circulating free T3 concentration	A deviation from the normal concentration of free triiodothyronine (T3) in the blood circulation. A proportion of T3 is bound to plasma proteins in the blood, including mainly thyroxine binding globulin, transthyretin, and albumin. T3 that is not bound to a protein is referred to as free T3.		hp.json	Abnormal circulating free triiodotyronine concentration|Abnormal circulating free T3 level	http://purl.obolibrary.org/obo/HP_0032209		
UBERON:0012469	biolink:AnatomicalEntity	external anal region		EHDAA2:0004589	hp.json		http://purl.obolibrary.org/obo/UBERON_0012469		
HP:0032204	biolink:PhenotypicFeature	Chronic active Epstein-Barr virus infection	Chronic active Epstein-Barr virus (EBV) infection is an uncommon outcome of EBV infection and may present as a waxing and waning or fulminant syndrome. Unlike acute infectious mononucleosis, wherein EBV establishes lifelong infection and survives by maintaining a delicate balance with the host as a latent infection, in chronic active EBV infection the host-virus balance is disturbed.		hp.json		http://purl.obolibrary.org/obo/HP_0032204		
CHEBI:60039	biolink:ChemicalSubstance	L-proline zwitterion	The zwitterion formed from L-proline by proton transfer from the carboxy group to the ring nitrogen. It is the predominant species at physiological pH.	MetaCyc:PRO	hp.json	L-proline|(2S)-pyrrolidinium-2-carboxylate	http://purl.obolibrary.org/obo/CHEBI_60039		3_STAR
HP:0032205	biolink:PhenotypicFeature	Increased circulating galectin-3 level	An increased circulation of galectin-3 in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032205		
HP:0032207	biolink:PhenotypicFeature	obsolete Abnormal cerebrospinal fluid metabolite concentration			hp.json		http://purl.obolibrary.org/obo/HP_0032207		
HP:0007291	biolink:PhenotypicFeature	Posterior fossa cyst	A discrete posterior fossa cerebrospinal fluid (CSF) collection that does not communicate directly with the fourth ventricle.	UMLS:C1857353	hp.json		http://purl.obolibrary.org/obo/HP_0007291		
HP:0007293	biolink:PhenotypicFeature	Anterior sacral meningocele		UMLS:C1867776	hp.json		http://purl.obolibrary.org/obo/HP_0007293		
UBERON:0000479	biolink:AnatomicalEntity	tissue	Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation.	XAO:0003040|AAO:0010054|galen:Tissue|TGMA:0001844|EHDAA2:0003043|CALOHA:TS-2090|AAO:0000607|BILA:0000043|FMA:9637|CARO:0000043|AEO:0000043|NCIT:C12801|ZFA:0001477|WBbt:0005729|TAO:0001477|HAO:0000043|MA:0003002|EMAPA:35868|VHOG:0001757|FBbt:00007003|BIRNLEX:19|MESH:D014024|UMLS:C0040300	hp.json	portion of tissue|tissue portion|simple tissue	http://purl.obolibrary.org/obo/UBERON_0000479		upper_level|pheno_slim
UBERON:0012464	biolink:AnatomicalEntity	cloacal vent	The opening of the cloacal chamber to the outside of the organism. Birds maintain a single cloacal opening throughout their lives.		hp.json	vent|cloacal opening|cloacal orifice	http://purl.obolibrary.org/obo/UBERON_0012464		
HP:0032211	biolink:PhenotypicFeature	Increased urinary epithelial cell count	An increased number of epithelial cells per high-power field in urinanalysis.		hp.json		http://purl.obolibrary.org/obo/HP_0032211		
HP:0032212	biolink:PhenotypicFeature	Increased urinary squamous epithelial cell count	An increased number of squamous epithelial cells per high-power field in urinanalysis.		hp.json		http://purl.obolibrary.org/obo/HP_0032212		
UBERON:0012463	biolink:AnatomicalEntity	cloacal lumen	An anatomical space that is enclosed by a cloaca.	ZFA:0000330|TAO:0000330	hp.json	cloaca lumen|cloacal chamber	http://purl.obolibrary.org/obo/UBERON_0012463		
HP:0032213	biolink:PhenotypicFeature	Increased urinary renal tubular epithelial cell count	An increased number of renal tubular epithelial cells per high-power field in urinanalysis.		hp.json		http://purl.obolibrary.org/obo/HP_0032213		
HP:0032214	biolink:PhenotypicFeature	Increased urinary transitional epithelial cell count	An increased number of transitional epithelial cells per high-power field in urinanalysis.		hp.json		http://purl.obolibrary.org/obo/HP_0032214		
UBERON:0012468	biolink:AnatomicalEntity	anal tooth	Triangular calcified papillae (often five) placed radially around the anus of some Holothuriidae.		hp.json	calcified anal papilla|perianal tooth|anal teeth|cloacal tooth	http://purl.obolibrary.org/obo/UBERON_0012468		
UBERON:0012467	biolink:AnatomicalEntity	enclosed anatomical space	An anatomical space with no opening to another space or to the exterior.	AEO:0000222	hp.json	closed anatomical space	http://purl.obolibrary.org/obo/UBERON_0012467		
UBERON:0012466	biolink:AnatomicalEntity	extraembryonic cavity		EMAPA:16054|VHOG:0000767|EHDAA2:0000472	hp.json	extraembryonic cavities	http://purl.obolibrary.org/obo/UBERON_0012466		
UBERON:0012465	biolink:AnatomicalEntity	lumen of terminal part of digestive tract	An anatomical space that is enclosed by a terminal part of digestive tract.		hp.json		http://purl.obolibrary.org/obo/UBERON_0012465		
HP:0032210	biolink:PhenotypicFeature	Decreased circulating free T3	A reduced concentration of free 3,3',5-triiodo-L-thyronine in the blood circulation.		hp.json	Decreased circulating free triiodothyronine	http://purl.obolibrary.org/obo/HP_0032210		
HP:0032219	biolink:PhenotypicFeature	Increased proportion of CD4-positive T cells	An elevation in the proportion of CD4-positive T cells relative to the total number of T cells.		hp.json	Elevated proportion of CD4-positive T cells|Increased proportion of CD4+ T cells|Increased proportion of CD4-positive, alpha-beta T cells	http://purl.obolibrary.org/obo/HP_0032219		
CL:1000311	biolink:Cell	adipocyte of epicardial fat of left ventricle	A fat cell that is part of the epicardial fat of left ventricle.	FMA:261300	hp.json	epicardial fat cell of left ventricle|epicardial adipocyte of left ventricle	http://purl.obolibrary.org/obo/CL_1000311		
CL:1000310	biolink:Cell	adipocyte of epicardial fat of right ventricle	A fat cell that is part of the epicardial fat of right ventricle.	FMA:261297	hp.json	epicardial adipocyte of right ventricle|epicardial fat cell of right ventricle	http://purl.obolibrary.org/obo/CL_1000310		
UBERON:0000481	biolink:AnatomicalEntity	multi-tissue structure	Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types.	ZFA:0001488|XAO:0003037|HAO:0000055|TAO:0001488|AAO:0010048|TGMA:0001847|EHDAA2:0003055|FBbt:00007010|VHOG:0001762|BILA:0000055|CARO:0000055|AEO:0000055	hp.json	multi-tissue structures	http://purl.obolibrary.org/obo/UBERON_0000481		upper_level
HP:0032215	biolink:PhenotypicFeature	Disseminated cutaneous warts	Multiple skin warts located in multiple parts of the body, e.g., neck, trunks, and extremities.		hp.json		http://purl.obolibrary.org/obo/HP_0032215		
HP:0032216	biolink:PhenotypicFeature	Lymphocytic infiltration of the colorectal mucosa	Abnormally increased intraepithelial lymphocyte count. This finding may be appreciated as large numbers of surface intraepithelial lymphocytes as seen (for instance) with hematoxylin and eosin staining of a colonic biopsy sample taken during colonoscopy.		hp.json		http://purl.obolibrary.org/obo/HP_0032216		
HP:0032217	biolink:PhenotypicFeature	Indurated nodule	A skin nodule that is unusually hard (indurated).		hp.json		http://purl.obolibrary.org/obo/HP_0032217		
HP:0032218	biolink:PhenotypicFeature	Decreased proportion of CD4-positive T cells	A reduction in the proportion of CD4-positive T cells relative to the total number of T cells.		hp.json	Decreased proportion of CD4+ cells|Reduced proportion of CD4-positive cells|Decreased proportion of CD4-positive, alpha-beta T cells	http://purl.obolibrary.org/obo/HP_0032218		
UBERON:0000486	biolink:AnatomicalEntity	multilaminar epithelium	Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA].	UMLS:C0682575|FMA:45562|HAO:0000069|XAO:0004006|BTO:0002074|Wikipedia:Stratified_epithelium|NCIT:C33622|AAO:0010059|ZFA:0001494|EHDAA2:0003069|TAO:0001494|SCTID:309044005|BILA:0000069|AEO:0000069|CARO:0000069	hp.json	stratified epithelium|laminated epithelium	http://purl.obolibrary.org/obo/UBERON_0000486		uberon_slim|vertebrate_core
UBERON:0000487	biolink:AnatomicalEntity	simple squamous epithelium	Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA].	ZFA:0001498|BTO:0002073|EHDAA2:0003070|BILA:0000070|TAO:0001498|AEO:0000070|UMLS:C0836133|CARO:0000070|NCIT:C13178|XAO:0004010|AAO:0010066|HAO:0000070|Wikipedia:Simple_squamous_epithelium|FMA:45565	hp.json	simple squamous epithelia|epithelium simplex squamosum	http://purl.obolibrary.org/obo/UBERON_0000487		uberon_slim|vertebrate_core
HP:0007289	biolink:PhenotypicFeature	Limb fasciculations	Fasciculations affecting the musculature of the arms and legs.	UMLS:C1854657	hp.json	Limb fasciculation	http://purl.obolibrary.org/obo/HP_0007289		
UBERON:0000488	biolink:AnatomicalEntity	atypical epithelium	Epithelium that consists of epithelial cells not arranged in one ore more layers.	EHDAA2:0003071|XAO:0004004|BILA:0000071|CARO:0000071|AEO:0000071|FMA:61741|AAO:0010057|ZFA:0001493|HAO:0000071|TAO:0001493	hp.json	atypical epithelia|heterogenous epithelium	http://purl.obolibrary.org/obo/UBERON_0000488		vertebrate_core
UBERON:0000489	biolink:AnatomicalEntity	cavitated compound organ	Compound organ that contains one or more macroscopic anatomical spaces.	VHOG:0001730|TAO:0001490|FMA:55671|EHDAA2:0003072|BILA:0000072|CARO:0000072|AEO:0000072|AAO:0010016|XAO:0003165|HAO:0000072|TGMA:0001857|ZFA:0001490	hp.json	cavitated compound organs|cavitated organ	http://purl.obolibrary.org/obo/UBERON_0000489		upper_level|organ_slim
UBERON:0000483	biolink:AnatomicalEntity	epithelium	Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO].	CALOHA:TS-0288|MESH:D004848|EMAPA:32738|ZFA:0001486|NCIT:C12710|BTO:0000416|HAO:0000066|Wikipedia:Epithelium|XAO:0003045|FBbt:00007005|TAO:0001486|UMLS:C0014609|SCTID:31610004|AAO:0000144|AAO:0010055|EHDAA2:0003066|FMA:9639|VHOG:0000387|BILA:0000066|AEO:0000066|GAID:402|CARO:0000066|MA:0003060	hp.json	epithelial tissue|portion of epithelium	http://purl.obolibrary.org/obo/UBERON_0000483		uberon_slim|vertebrate_core|pheno_slim
HP:0007285	biolink:PhenotypicFeature	Facial palsy secondary to cranial hyperostosis	Paralysis of the facial nerves on the basis of overgrowth of the cranial bones causing impingement upon the seventh cranial nerve.	UMLS:C1849260	hp.json	Facial palsy secondary to hypertrophy of cranial bones|Facial palsy caused by enlargement of cranial bones|Facial palsy caused by excessive growth of facial bones|Facial palsy caused by overgrowth of cranial bones	http://purl.obolibrary.org/obo/HP_0007285		
HP:0007286	biolink:PhenotypicFeature	Horizontal jerk nystagmus	Nystagmus consisting of horizontal to-and-fro eye movements, in which the movement in one direction is faster than in the other.	UMLS:C4024910	hp.json		http://purl.obolibrary.org/obo/HP_0007286		
UBERON:0000484	biolink:AnatomicalEntity	simple cuboidal epithelium	Unilaminar epithelium that consists of a single layer of cuboidal cells.	XAO:0004009|HAO:0000067|ZFA:0001497|NCIT:C33553|TAO:0001497|Wikipedia:Simple_cuboidal_epithelium|UMLS:C0836134|EHDAA2:0003067|AAO:0010064|FMA:45566|BILA:0000067|AEO:0000067|CARO:0000067	hp.json	epithelium simplex cuboideum|simple cuboidal epithelia	http://purl.obolibrary.org/obo/UBERON_0000484		uberon_slim|vertebrate_core
UBERON:0000485	biolink:AnatomicalEntity	simple columnar epithelium	Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA].	XAO:0004008|SCTID:32210007|EHDAA2_RETIRED:0003068|HAO:0000068|ZFA:0001496|FBbt:00007027|UMLS:C0836135|NCIT:C33552|TAO:0001496|Wikipedia:Simple_columnar_epithelium|FMA:45567|BILA:0000068|AAO:0010063|AEO:0000068|CARO:0000068	hp.json	simple columnar epithelium|columnar epithlium|columnar epithelium|simple columnar epithelia|epithelium simplex columnare	http://purl.obolibrary.org/obo/UBERON_0000485		uberon_slim|vertebrate_core
UBERON:0000468	biolink:AnatomicalEntity	multicellular organism	Anatomical structure that is an individual member of a species and consists of more than one cell.	ZFA:0001094|BIRNLEX:18|WBbt:0007833|TADS:0000001|TGMA:0001832|EMAPA:25765|BILA:0000012|CARO:0000012|NCIT:C13041|TAO:0001094|galen:Organism|BTO:0000042|EFO:0002906|VHOG:0000671|FMA:256135|Wikipedia:Multi-cellular_organism|ncithesaurus:Whole_Organism|HAO:0000012|XAO:0003004|FBbt:00000001|EHDAA2:0003191|SCTID:243928005|BSA:0000038|EV:0100016|AAO:0010026|AEO:0000191|EHDAA2:0003103|EHDAA:1	hp.json	multi-cellular organism|Koerper|whole body|organism|whole organism|body	http://purl.obolibrary.org/obo/UBERON_0000468		efo_slim|uberon_slim|upper_level|pheno_slim
HP:0032222	biolink:PhenotypicFeature	Serrated intestinal polyps	The presence of multiple serrated polyps in the intestine. Unlike conventional adenomas, which are uniformly dysplastic, the vast majority of serrated lesions contain no dysplasia. The serrated class includes the hyperplastic polyps, which are not considered precancerous; sessile serrated polyps (also called sessile serrated adenomas); and traditional serrated adenomas. Sessile serrated polyps are larger on average and more often located in the proximal colon. Sessile serrated polyps have a more irregular surface, a pattern to the surface that has been called cloudlike, and indistinct edges compared with hyperplastic polyps. Sessile serrated polyps also have large open pits on the surface (type O pits) when viewed with magnification.		hp.json	Serrated polyposis	http://purl.obolibrary.org/obo/HP_0032222		
CL:1000309	biolink:Cell	epicardial adipocyte	A fat cell that is part of the epicardial fat.	FMA:261293	hp.json	adipocyte of epicardial fat|epicardial fat cell	http://purl.obolibrary.org/obo/CL_1000309		
HP:0032223	biolink:PhenotypicFeature	Blood group	Any of the various types of human blood whose antigen characteristics determine compatibility in transfusion. While the ABO and Rhesus sytems are the most well known, there are in total about 300 different blood type antigens distributed across 34 different blood type systems.		hp.json		http://purl.obolibrary.org/obo/HP_0032223		
HP:0032224	biolink:PhenotypicFeature	ABO blood group	The ABO system consists of A and B antigens and antibodies against these antigens.		hp.json		http://purl.obolibrary.org/obo/HP_0032224		
CL:1000307	biolink:Cell	fibroblast of dense regular elastic tissue	A fibroblast that is part of the dense regular elastic tissue.	FMA:261287	hp.json		http://purl.obolibrary.org/obo/CL_1000307		
CL:1000306	biolink:Cell	fibroblast of tunica adventitia of artery	A fibroblast that is part of the tunica adventitia of artery.	FMA:261285	hp.json		http://purl.obolibrary.org/obo/CL_1000306		
HP:0032225	biolink:PhenotypicFeature	Perifollicular fibroma	Perifollicular fibroma is a rare cutaneous hamartoma that shows differentiation in the connective tissue sheath of hair follicles. It can occur as a solitary papule or as multiple lesions. Histologically, the lesion consists of a concentric arrangement of cellular fibrous tissue around a normal hair follicle.		hp.json		http://purl.obolibrary.org/obo/HP_0032225		
HP:0032220	biolink:PhenotypicFeature	Interface hepatitis	Inflammation of the liver characterized by a mononuclear cell infiltrate whereby portal inflammatory cells extend through the limiting plate between the portal tract and liver parenchyma.		hp.json		http://purl.obolibrary.org/obo/HP_0032220		
CL:1000303	biolink:Cell	fibroblast of areolar connective tissue	A fibroblast that is part of the areolar connective tissue.	FMA:261279	hp.json		http://purl.obolibrary.org/obo/CL_1000303		
HP:0032221	biolink:PhenotypicFeature	Periportal emperipolesis	The engulfing of lymphocytes by hepatocytes, which typically occurs in the interface hepatitis area.		hp.json		http://purl.obolibrary.org/obo/HP_0032221		
CHEBI:37622	biolink:ChemicalSubstance	carboxamide	An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom.		hp.json	carboxamides|primary carboxamide|carboxamides	http://purl.obolibrary.org/obo/CHEBI_37622		3_STAR
CHEBI:60059	biolink:ChemicalSubstance	dermatan anion	A carbohydrate acid derivative anion obtained from dermatan by deprotonation of the carboxylic acid groups of the repeating units; the major species at pH 7.3.		hp.json	dermatan|dermatan polyanion	http://purl.obolibrary.org/obo/CHEBI_60059		3_STAR
HP:0032226	biolink:PhenotypicFeature	Abnormal sebaceous gland morphology	Any structural anomaly of the sebaceous glands.		hp.json		http://purl.obolibrary.org/obo/HP_0032226		
CHEBI:37627	biolink:ChemicalSubstance	L-glucopyranose	The L-enantiomer of glucopyranose.	Reaxys:2206321|Beilstein:2206321|GlyTouCan:G16038XU|GlyGen:G16038XU	hp.json	L-glucopyranose|WURCS=2.0/1,1,0/[a1211h-1x_1-5]/1/	http://purl.obolibrary.org/obo/CHEBI_37627		3_STAR
HP:0032227	biolink:PhenotypicFeature	Sebaceous hyperplasia	A common, benign skin condition involving hypertrophy of the sebaceous glands characterized by single or multiple lesions that manifest as yellow, soft, small papules with umbilication. The lesions are located commonly on the central face (specifically, the nose, cheeks and forehead) but may also occur elswehere, including the chest, mouth, scrotum, foreskin, penile shaft, vulva, and areola.		hp.json		http://purl.obolibrary.org/obo/HP_0032227		
HP:0032228	biolink:PhenotypicFeature	Trichodiscoma	A small benign fibrovascular tumor of the dermal part of the hair disk. Trichodiscoma is rather simple in appearance and consists of a dome-shaped fibrous tumor with a prominent vascular component that fills the papillary dermis under an atrophic epidermis. As in a normal hair disk, a hair follicle may be present at one edge of the papular lesion.		hp.json		http://purl.obolibrary.org/obo/HP_0032228		
CHEBI:37624	biolink:ChemicalSubstance	L-glucose		CAS:921-60-8|Beilstein:1724626	hp.json	L-gluco-hexose|L(-)-glucose|L-glucose	http://purl.obolibrary.org/obo/CHEBI_37624		3_STAR
HP:0032229	biolink:PhenotypicFeature	Perinuclear antineutrophil antibody positivity	The presence of autoantibodies in the serum that react against proteins predominantly expressed in perinuclear region of neutrophils.		hp.json	p-ANCA positivity	http://purl.obolibrary.org/obo/HP_0032229		
UBERON:0000475	biolink:AnatomicalEntity	organism subdivision	Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument.	EHDAA2:0003032|MAT:0000293|TAO:0001308|BILA:0000032|AEO:0000032|TGMA:0001840|CARO:0000032|MIAA:0000293|FBbt:00007009|Wikipedia:Body_part|MA:0002433|OpenCyc:Mx4rvViAHJwpEbGdrcN5Y29ycA|XAO:0003013|HAO:0000032|EMAPA:36031|VHOG:0001758|BIRNLEX:7|NCIT:C32221|UMLS:C0229962|CALOHA:TS-2084|FMA:7153|MESH:D001829|ZFA:0001308|galen:BodyPart|AAO:0010053|EFO:0000808	hp.json	anatomic region|body part|body region|cardinal body part	http://purl.obolibrary.org/obo/UBERON_0000475		uberon_slim|upper_level|pheno_slim|efo_slim
HP:0007299	biolink:PhenotypicFeature	Dysfunction of lateral corticospinal tracts		UMLS:C1832671	hp.json		http://purl.obolibrary.org/obo/HP_0007299		
UBERON:0000476	biolink:AnatomicalEntity	acellular anatomical structure	Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue.	TGMA:0001841|EHDAA2:0003040|BILA:0000040|CARO:0000040|AEO:0000040|AAO:0010268|HAO:0000040|ZFA:0000382|FMA:63863|FBbt:00007013|XAO:0003162|TAO:0000382	hp.json	acellular anatomical structures	http://purl.obolibrary.org/obo/UBERON_0000476		vertebrate_core
UBERON:0000477	biolink:AnatomicalEntity	anatomical cluster	Anatomical group that has its parts adjacent to one another.	XAO:0003160|TGMA:0001842|EHDAA2:0003041|ZFA:0001478|BILA:0000041|AAO:0010009|FMA:49443|CARO:0000041|AEO:0000041|TADS:0000605|TAO:0001478|VHOG:0001737|HAO:0000041|FBbt:00007277	hp.json		http://purl.obolibrary.org/obo/UBERON_0000477		upper_level
UBERON:0000478	biolink:AnatomicalEntity	extraembryonic structure	A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis.	UMLS:C1282438|CALOHA:TS-2119|AAO:0010020|TGMA:0001843|EHDAA2:0003042|FBbt:00005835|SCTID:314908006|BILA:0000042|CARO:0000042|AEO:0000042|XAO:0004005|FMA:85537|VHOG:0000292|EHDAA:46|HAO:0000042|ZFA:0000020|NCIT:C34055|TAO:0000020	hp.json	extraembryonic tissue|extra-embryonic structure|extraembryonic structures	http://purl.obolibrary.org/obo/UBERON_0000478		uberon_slim|vertebrate_core|pheno_slim
UBERON:0000471	biolink:AnatomicalEntity	compound organ component	Multi-tissue structure that is part of a compound organ.	ZFA:0001489|XAO:0003039|TAO:0001489|AAO:0010017|EHDAA2:0003019|BILA:0000019|AEO:0000019|CARO:0000019|TGMA:0001835|HAO:0000019	hp.json	compound organ components	http://purl.obolibrary.org/obo/UBERON_0000471		upper_level
HP:0007295	biolink:PhenotypicFeature	Chaotic rapid conjugate ocular movements		UMLS:C4024909	hp.json		http://purl.obolibrary.org/obo/HP_0007295		
CL:0002294	biolink:Cell	type-1 epithelial cell of thymus	An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule.	FMA:72209	hp.json	subcapsular thymic epithelial cell	http://purl.obolibrary.org/obo/CL_0002294		
CL:0002293	biolink:Cell	epithelial cell of thymus	An epithelial cell of the thymus. Epithelial reticular cells are pleomorphic, stellate, non-phagocytic cells which seem to be supportive in function and are held together by desmosomes. They replace the fibroblastoid reticular cells found in other lymphoid organs. Other epithelial cells in the medulla have the ultrastructure of secretory cells. Although different epithelial cells throughout the thymus appear alike by light microscopy their ultrastructure and function varies.	CALOHA:TS-1040|FMA:72208	hp.json	thymic epithelial cell|epithelial cell of thymus gland|epithelial reticular cell|epithelial reticular cell of thymus	http://purl.obolibrary.org/obo/CL_0002293		
PR:Q14376	biolink:Protein	UDP-glucose 4-epimerase (human)	A UDP-glucose 4-epimerase that is encoded in the genome of human.	UniProtKB:Q14376|Reactome:R-HSA-70362	hp.json	UDP-galactose 4-epimerase (human)|GALE|hGALE|UDP-N-acetylgalactosamine 4-epimerase (human)|UDP-GlcNAc 4-epimerase (human)|UDP-N-acetylglucosamine 4-epimerase (human)|galactowaldenase (human)|UDP-GalNAc 4-epimerase (human)	http://purl.obolibrary.org/obo/PR_Q14376		
UBERON:0000473	biolink:AnatomicalEntity	testis	A gonad of a male animal. A gonad produces and releases sperm.	MIAA:0000132|BTO:0001363|HAO:0001007|AAO:0000606|MESH:D013737|XAO:0000157|WBbt:0006794|VHOG:0000252|ZFA:0000598|EMAPA:17972|MA:0000411|EHDAA2:0002007|TAO:0000598|NCIT:C12412|galen:Testis|GAID:396|FMA:7210|CALOHA:TS-1030|EFO:0000984|EV:0100102|OpenCyc:Mx4rvVjM25wpEbGdrcN5Y29ycA|FBbt:00004928|MAT:0000132|UMLS:C0039597|BILA:0000124|EHDAA:8146|BSA:0000085	hp.json	testes|gonad of male reproductive system|gonad of male genitalia|testicle|orchis|testiculus|male gonad	http://purl.obolibrary.org/obo/UBERON_0000473		uberon_slim|vertebrate_core|organ_slim|pheno_slim|efo_slim
UBERON:0000474	biolink:AnatomicalEntity	female reproductive system	The organs and associated structures associated with bearing offspring in a female animal.	CALOHA:TS-1303|FMA:45663|EHDAA2:0000506|HAO:0000324|EFO:0000969|OpenCyc:Mx4rvVipTZwpEbGdrcN5Y29ycA|Wikipedia:Female_genitalia|XAO:0000156|BTO:0000083|FBbt:00004864|MESH:D005836|NCIT:C12402|GAID:364|VHOG:0000726|MIAA:0000028|EHDAA:8116|EMAPA:17959|SCTID:361386004|EV:0100110|MA:0000381|TGMA:0000635|UMLS:C0700038|WikipediaCategory:Female_reproductive_system	hp.json	female genital tract|genitalia of female organism|systema genitale femininum|reproductive system of female organism|female reproductive tract|female genitals|female organism reproductive system|female genital system|gynaecological tissue|female organism genitalia|female genitalia	http://purl.obolibrary.org/obo/UBERON_0000474		uberon_slim|pheno_slim|efo_slim
GO:0001775	biolink:BiologicalProcess	cell activation	A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.		hp.json		http://purl.obolibrary.org/obo/GO_0001775		goslim_pir
GO:0001776	biolink:BiologicalProcess	leukocyte homeostasis	The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.		hp.json	leucocyte homeostasis|immune cell homeostasis	http://purl.obolibrary.org/obo/GO_0001776		
GO:0001777	biolink:BiologicalProcess	T cell homeostatic proliferation	The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.		hp.json	T lymphocyte homeostatic proliferation|T-lymphocyte homeostatic proliferation|resting T cell proliferation|resting T-cell proliferation|T-cell homeostatic proliferation	http://purl.obolibrary.org/obo/GO_0001777		
GO:0001773	biolink:BiologicalProcess	myeloid dendritic cell activation	The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.		hp.json		http://purl.obolibrary.org/obo/GO_0001773		
HP:0010841	biolink:PhenotypicFeature	Multifocal epileptiform discharges	An abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG) and being identified at multiple locations (foci).	UMLS:C4021219	hp.json	Multifocal EEG abnormality	http://purl.obolibrary.org/obo/HP_0010841		
GO:0060073	biolink:BiologicalProcess	micturition	The regulation of body fluids process in which parasympathetic nerves stimulate the bladder wall muscle to contract and expel urine from the body.	Wikipedia:Urination	hp.json	urine voiding|urination	http://purl.obolibrary.org/obo/GO_0060073		
HP:0010849	biolink:PhenotypicFeature	EEG with spike-wave complexes (>3.5 Hz)	The presence of complexes of spikes and waves (>3.5 Hz) in electroencephalography (EEG).	UMLS:C4023684|UMLS:C4020765	hp.json	EEG with 3-4-Hz spike waves	http://purl.obolibrary.org/obo/HP_0010849		
HP:0009849	biolink:PhenotypicFeature	Symphalangism of middle phalanx of finger	Fusion of a middle phalanx of a finger with another bone.	UMLS:C4024184	hp.json	Fused middle finger bone	http://purl.obolibrary.org/obo/HP_0009849		
HP:0010848	biolink:PhenotypicFeature	EEG with spike-wave complexes (2.5-3.5 Hz)	The presence of complexes of spikes and waves (2.5-3.5 Hz) in electroencephalography (EEG).	UMLS:C4023685	hp.json		http://purl.obolibrary.org/obo/HP_0010848		
HP:0009848	biolink:PhenotypicFeature	Patchy sclerosis of middle phalanx of finger	Uneven (irregular) increase in bone density of one or more of the middle phalanges of the hand.	UMLS:C4021382	hp.json	Uneven increase in bone density in the middle finger bones of the hand|Patchy sclerosis of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009848		
HP:0010847	biolink:PhenotypicFeature	EEG with spike-wave complexes (<2.5 Hz)	The presence of complexes of slow spikes and slow waves (<2.5 Hz) in electroencephalography (EEG).	UMLS:C4023686	hp.json	Electroencephalogram demonstrated spike-slow wave discharges	http://purl.obolibrary.org/obo/HP_0010847		
HP:0010846	biolink:PhenotypicFeature	EEG with persistent abnormal rhythmic activity		UMLS:C4021216	hp.json	EEG: persistent abnormal rhythmic activity	http://purl.obolibrary.org/obo/HP_0010846		
HP:0010845	biolink:PhenotypicFeature	EEG with generalized slow activity	Diffuse slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG).	UMLS:C4021217	hp.json	EEG: generalized slow activity|EEG: generalised slow activity|EEG with generalised slow activity	http://purl.obolibrary.org/obo/HP_0010845		
HP:0009845	biolink:PhenotypicFeature	Bullet-shaped middle phalanges of the hand	Any of the middle phalanges with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4024187	hp.json		http://purl.obolibrary.org/obo/HP_0009845		
HP:0009844	biolink:PhenotypicFeature	Broad middle phalanx of finger	Increased width of the middle phalanx of finger.	UMLS:C4021383	hp.json	Broad middle phalanges of the hand|Broad middle finger bones|Broad middle phalanges of finger	http://purl.obolibrary.org/obo/HP_0009844		
HP:0010844	biolink:PhenotypicFeature	EEG with multifocal slow activity	Multifocal slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG).	UMLS:C4023687	hp.json		http://purl.obolibrary.org/obo/HP_0010844		
HP:0010843	biolink:PhenotypicFeature	EEG with focal slow activity	Focal (localized) slow activity reflects focal dysfunction, not diffuse dysfunction (i.e., encephalopathy).	UMLS:C4021218	hp.json	EEG: localized slow activity|EEG: focal slow activity|EEG: localised slow activity	http://purl.obolibrary.org/obo/HP_0010843		
HP:0009847	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanges of the hand		UMLS:C4024185	hp.json		http://purl.obolibrary.org/obo/HP_0009847		
HP:0009846	biolink:PhenotypicFeature	Curved middle phalanges of the hand		UMLS:C4024186	hp.json	Curved middle finger bonds of the hand	http://purl.obolibrary.org/obo/HP_0009846		
HP:0009840	biolink:PhenotypicFeature	Patchy sclerosis of distal phalanx of finger	Uneven (irregular) increase in bone density of the distal phalanges of the hand.	UMLS:C4021384	hp.json	Uneven increase in bone density in outermost finger bone|Patchy sclerosis of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009840		
HP:0009843	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanges of the hand		UMLS:C1862152	hp.json	Aplasia/hypoplasia of middle phalanges|Short to absent middle phalanges|Absent/small middle finger bone of the hand|Absent/hypoplastic middle phalanges|Hypoplastic/aplastic middle phalanx|Short/absent middle phalanges|Aplastic/hypoplastic middle phalanges|Absent/underdeveloped middle finger bone of the hand	http://purl.obolibrary.org/obo/HP_0009843		
GO:0001781	biolink:BiologicalProcess	neutrophil apoptotic process	Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.		hp.json	neutrophil programmed cell death by apoptosis|programmed cell death of neutrophils by apoptosis|apoptosis of neutrophils|neutrophil apoptosis|programmed cell death, neutrophils	http://purl.obolibrary.org/obo/GO_0001781		
HP:0010830	biolink:PhenotypicFeature	Impaired tactile sensation	A reduced sense of touch (tactile sensation). This is usually tested with a wisp of cotton or a fine camel's hair brush, by asking patients to say 'now' each time they feel the stimulus.	UMLS:C4021221	hp.json	Abnormal thigmesthesia|Loss of tactile sensation|Impaired touch sensation	http://purl.obolibrary.org/obo/HP_0010830		
GO:0001780	biolink:BiologicalProcess	neutrophil homeostasis	The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0001780		
GO:0060065	biolink:BiologicalProcess	uterus development	The reproductive developmental process whose specific outcome is the progression of the uterus over time, from its formation to the mature structure.		hp.json	Mullerian tract development	http://purl.obolibrary.org/obo/GO_0060065		
GO:0060066	biolink:BiologicalProcess	oviduct development	The reproductive developmental process whose specific outcome is the progression of an oviduct over time, from its formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism.		hp.json	Mullerian tract development|fallopian tube development	http://purl.obolibrary.org/obo/GO_0060066		
HP:0010838	biolink:PhenotypicFeature	High nonceruloplasmin-bound serum copper	An increased concentration of non ceruloplasmin bound copper in the blood.	UMLS:C1848459	hp.json		http://purl.obolibrary.org/obo/HP_0010838		
HP:0010837	biolink:PhenotypicFeature	Decreased circulating ceruloplasmin concentration	Decreased concentration of ceruloplasmin in the blood.	UMLS:C0240997	hp.json	Hypoceruloplasminemia|Decreased serum ceruloplasminA|Hypoceruloplasminaemia|Decreased serum ceruloplasmin	http://purl.obolibrary.org/obo/HP_0010837		
HP:0010836	biolink:PhenotypicFeature	Abnormal circulating copper concentration	An abnormal concentration of copper.	UMLS:C4020766|UMLS:C4023689	hp.json	Abnormal copper levels	http://purl.obolibrary.org/obo/HP_0010836		
HP:0010835	biolink:PhenotypicFeature	Dissociated sensory loss	A pattern of sensory loss with selective loss of touch sensation and proprioception without loss of pain and temperature, or vice-versa.	UMLS:C0278136|SNOMEDCT_US:87275002	hp.json		http://purl.obolibrary.org/obo/HP_0010835		
HP:0010834	biolink:PhenotypicFeature	Trophic changes related to pain	Trophic changes is a term used to describe abnormalities in the area of pain that include primarily wasting away of the skin, tissues, or muscle, thinning of the bones, and changes in how the hair or nails grow, including thickening or thinning of hair or brittle nails.	UMLS:C4021220	hp.json	Trophic changes	http://purl.obolibrary.org/obo/HP_0010834		
HP:0009856	biolink:PhenotypicFeature	Patchy sclerosis of proximal phalanx of finger	Uneven increase in bone density of the proximal phalanges of the hand.	UMLS:C4021381	hp.json	Uneven increase in bone density in innermost finger bone|Patchy sclerosis of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009856		
HP:0009855	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanges of the hand		UMLS:C1850148	hp.json	Proximal phalanges osteolysis	http://purl.obolibrary.org/obo/HP_0009855		
HP:0010833	biolink:PhenotypicFeature	Spontaneous pain sensation	Spontaneous pain is a kind of neuropathic pain which occurs without an identifiable trigger.	UMLS:C4023690	hp.json		http://purl.obolibrary.org/obo/HP_0010833		
HP:0010832	biolink:PhenotypicFeature	Abnormality of pain sensation	Pain is an unpleasant sensation that can range from mild, localized discomfort to agony, whereby the physical part of pain results from nerve stimulation and is often accompanied by an emotional component. This term groups abnormalities in pain sensation presumed to result from abnormalities related to the specific nerve fibers that carry the pain impulses to the brain.	UMLS:C4023691	hp.json		http://purl.obolibrary.org/obo/HP_0010832		
HP:0009858	biolink:PhenotypicFeature	Triangular shaped proximal phalanges of the hand		UMLS:C4024177	hp.json	Triangular shaped innermost finger bone	http://purl.obolibrary.org/obo/HP_0009858		
HP:0009857	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanges of the hand		UMLS:C4024178	hp.json	Fused innermost hand bones	http://purl.obolibrary.org/obo/HP_0009857		
HP:0010831	biolink:PhenotypicFeature	Impaired proprioception	A loss or impairment of the sensation of the relative position of parts of the body and joint position.	UMLS:C1856691	hp.json	Abnormality of proprioception	http://purl.obolibrary.org/obo/HP_0010831		
HP:0009852	biolink:PhenotypicFeature	Broad proximal phalanges of the hand	Increased width of the proximal phalanges of the finger.	UMLS:C4024181	hp.json	Broad innermost finger bones of the hand|Wide innermost finger bones of the hand	http://purl.obolibrary.org/obo/HP_0009852		
HP:0009851	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the proximal phalanges of the hand		UMLS:C4024182	hp.json	Absent/small innermost finger bones of the hand|Absent/underdeveloped innermost finger bones of the hand	http://purl.obolibrary.org/obo/HP_0009851		
HP:0009854	biolink:PhenotypicFeature	Curved proximal phalanges of the hand		UMLS:C4024179	hp.json	Curved innermost finger bones of the hand	http://purl.obolibrary.org/obo/HP_0009854		
HP:0009853	biolink:PhenotypicFeature	Bullet-shaped proximal phalanges of the hand	Short and wide proximal phalanges that taper distally . Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4024180	hp.json	Bullet-shaped innermost finger bones of the hand	http://purl.obolibrary.org/obo/HP_0009853		
HP:0009850	biolink:PhenotypicFeature	Triangular shaped middle phalanges of the hand		UMLS:C4024183	hp.json	Triangular shaped middle finger bones of the hand	http://purl.obolibrary.org/obo/HP_0009850		
HP:0010839	biolink:PhenotypicFeature	Increased urinary copper concentration	An increased concentration of copper in the urine.	UMLS:C4023688	hp.json	Increased urinary copper concentration	http://purl.obolibrary.org/obo/HP_0010839		
GO:0098664	biolink:BiologicalProcess	G protein-coupled serotonin receptor signaling pathway	The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands.		hp.json	G-protein coupled serotonin receptor signaling pathway	http://purl.obolibrary.org/obo/GO_0098664		
GO:0098665	biolink:CellularComponent	serotonin receptor complex	A protein complex that is capable of serotonin receptor activity.		hp.json	5-hydroxytryptamine receptor complex|5HT receptor complex|5-HT receptor complex	http://purl.obolibrary.org/obo/GO_0098665		
GO:0098662	biolink:BiologicalProcess	inorganic cation transmembrane transport	A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.		hp.json	transmembrane inorganic cation transport|inorganic cation membrane transport|monovalent inorganic cation transport|divalent inorganic cation transport	http://purl.obolibrary.org/obo/GO_0098662		
GO:0001754	biolink:BiologicalProcess	eye photoreceptor cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.		hp.json		http://purl.obolibrary.org/obo/GO_0001754		
GO:0001755	biolink:BiologicalProcess	neural crest cell migration	The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.		hp.json		http://purl.obolibrary.org/obo/GO_0001755		
GO:0098660	biolink:BiologicalProcess	inorganic ion transmembrane transport	The process in which an inorganic ion is transported across a membrane.		hp.json	inorganic ion membrane transport|transmembrane inorganic ion transport	http://purl.obolibrary.org/obo/GO_0098660		
GO:0098661	biolink:BiologicalProcess	inorganic anion transmembrane transport	The process in which an inorganic anion is transported across a membrane.		hp.json	transmembrane inorganic anion transport|inorganic anion membrane transport	http://purl.obolibrary.org/obo/GO_0098661		
GO:0001751	biolink:BiologicalProcess	compound eye photoreceptor cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.		hp.json		http://purl.obolibrary.org/obo/GO_0001751		
HP:0009827	biolink:PhenotypicFeature	Amelia	Congenital absence (aplasia) of one or more limbs.	MSH:D004480|MEDDRA:10001926|SNOMEDCT_US:62588002|UMLS:C0002447	hp.json		http://purl.obolibrary.org/obo/HP_0009827		hposlim_core
HP:0010827	biolink:PhenotypicFeature	Abnormality of the seventh cranial nerve	Abnormality of the seventh cranial nerve sometimes also referred to as the facial nerve.	UMLS:C4021223	hp.json	Abnormality of the facial nerve	http://purl.obolibrary.org/obo/HP_0010827		
HP:0010826	biolink:PhenotypicFeature	Abnormality of the twelfth cranial nerve	Abnormality of the twelfth cranial nerve.	UMLS:C4021224	hp.json	Abnormality of the hypoglossal nerve|Abnormality of cranial nerve 12|Abnormality of cranial nerve xii	http://purl.obolibrary.org/obo/HP_0010826		
HP:0009826	biolink:PhenotypicFeature	Limb undergrowth	Limb shortening because of underdevelopment of one or more bones of the extremities.	UMLS:C0239399	hp.json	Limb undergrowth|limb shortening|Short limbs|Hypoplasia involving bones of the extremities|Short limb	http://purl.obolibrary.org/obo/HP_0009826		
HP:0009829	biolink:PhenotypicFeature	Phocomelia	Missing or malformed long bones of the extremities with the distal parts (such as hands and/or feet) connected to the variably shortened or even absent extremity, leading to a flipper-like appearance, as opposed to other forms of limb malformations were either the hole limb is missing (such as amelia), or the distal part of a limb is absent (peromelia).	MSH:D004480|MEDDRA:10034923|UMLS:C0031575|SNOMEDCT_US:22841008	hp.json		http://purl.obolibrary.org/obo/HP_0009829		hposlim_core
HP:0010825	biolink:PhenotypicFeature	Abnormality of the eleventh cranial nerve	Abnormality of the eleventh cranial nerve.	UMLS:C4021225	hp.json	Abnormality of the accessory nerve|Abnormality of cranial nerve XI	http://purl.obolibrary.org/obo/HP_0010825		
HP:0010824	biolink:PhenotypicFeature	Abnormal fifth cranial nerve morphology	Any structural abormality of the fifth cranial nerve.	UMLS:C4021226	hp.json	Abnormality of the nervus trigeminus|Abnormality of the fifth cranial nerve|Abnormal trigeminal nerve morphology	http://purl.obolibrary.org/obo/HP_0010824		
HP:0009828	biolink:PhenotypicFeature	Peromelia	The distal parts of the limbs are missing leading to a stump formation.	UMLS:C4024192	hp.json		http://purl.obolibrary.org/obo/HP_0009828		
HP:0010823	biolink:PhenotypicFeature	Ridged cranial sutures	An overlap of the bony plates of the skull in an infant, with or without early closure.	UMLS:C4023692	hp.json	Cranial suture ridges	http://purl.obolibrary.org/obo/HP_0010823		hposlim_core
HP:0009823	biolink:PhenotypicFeature	Aplasia involving bones of the upper limbs		UMLS:C4024194	hp.json	Absent bones of the upper limbs	http://purl.obolibrary.org/obo/HP_0009823		
HP:0010822	biolink:PhenotypicFeature	Scintillating scotoma	A scintillating scotoma is a common visual aura that can preced a migraine, whereby a spot of flickering light near the center of the visual fields occurs. The spot prevents vision, and is thus termed scotoma. The scotoma can extend into one or more shimmering arcs of white or colored flashing lights.	MSH:D012607|UMLS:C0235068|SNOMEDCT_US:2228002	hp.json		http://purl.obolibrary.org/obo/HP_0010822		
HP:0009822	biolink:PhenotypicFeature	Aplasia involving forearm bones		UMLS:C4024195	hp.json	Absent forearm bones	http://purl.obolibrary.org/obo/HP_0009822		
HP:0009825	biolink:PhenotypicFeature	Aplasia involving bones of the extremities		UMLS:C4024193	hp.json	Absent bones of the extremities	http://purl.obolibrary.org/obo/HP_0009825		
HP:0010821	biolink:PhenotypicFeature	Focal emotional seizure with laughing	Focal emotional seizure with laughing (gelastic) is characterized by bursts of laughter or giggling, usually without appropriate related emotion of happiness, and described as 'mirthless'.	SNOMEDCT_US:89525009|MSH:D004828|UMLS:C0270820	hp.json	Gelastic seizures|Gelastic seizure	http://purl.obolibrary.org/obo/HP_0010821		
HP:0010820	biolink:PhenotypicFeature	Focal emotional seizure with crying	Focal emotional seizure with crying (dacrystic) is characterized by the presence of stereotyped crying, this may be accompanied by lacrimation, sad facial expression and sobbing. The subjective emotion of sadness may or may not be present.	UMLS:C4023693	hp.json	Dacrystic seizure|Dacrystic seizures	http://purl.obolibrary.org/obo/HP_0010820		
HP:0009824	biolink:PhenotypicFeature	Upper limb undergrowth	Arm shortening because of underdevelopment of one or more bones of the upper extremity.	UMLS:C1837406	hp.json	Upper limb undergrowth|Shortening of the arms|Short arms|Hypoplasia involving bones of the upper limbs	http://purl.obolibrary.org/obo/HP_0009824		
HP:0009821	biolink:PhenotypicFeature	Forearm undergrowth	Forearm shortening because of underdevelopment of one or more bones of the forearm.	UMLS:C1855299	hp.json	Forearm undergrowth|Short forearm bones|Hypoplasia involving forearm bones|Short forearms|Shortened forearm	http://purl.obolibrary.org/obo/HP_0009821		
HP:0009820	biolink:PhenotypicFeature	Lower limb peromelia	Peromelia affecting only the lower limbs. That is, the distal parts of the leg are missing leading to stump formation.	UMLS:C4024196	hp.json		http://purl.obolibrary.org/obo/HP_0009820		
GO:0001756	biolink:BiologicalProcess	somitogenesis	The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.	Wikipedia:Somitogenesis	hp.json	formation of mesodermal clusters	http://purl.obolibrary.org/obo/GO_0001756		
HP:0010829	biolink:PhenotypicFeature	Impaired temperature sensation	A reduced ability to discriminate between different temperatures.	UMLS:C4021222	hp.json	Impaired thermal sensitivity|Loss of temperature sensation|Abnormality of temperature sensation|Impaired temperature sensation	http://purl.obolibrary.org/obo/HP_0010829		
GO:0098666	biolink:CellularComponent	G protein-coupled serotonin receptor complex	A protein complex that is capable of G protein-coupled serotonin receptor activity.		hp.json	G-protein coupled serotonin receptor complex	http://purl.obolibrary.org/obo/GO_0098666		
HP:0010828	biolink:PhenotypicFeature	Hemifacial spasm	Intermittent clonic or tonic contraction of muscles supplied by facial nerve. Muscles are relaxed in between contractions.	MSH:D019569|SNOMEDCT_US:13753008|UMLS:C0278152	hp.json	Hemifacial spasms|Spasms on one side of the face	http://purl.obolibrary.org/obo/HP_0010828		
GO:0001763	biolink:BiologicalProcess	morphogenesis of a branching structure	The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.		hp.json	branching morphogenesis	http://purl.obolibrary.org/obo/GO_0001763		
GO:0001764	biolink:BiologicalProcess	neuron migration	The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.	Wikipedia:Neural_development#Neuron_migration|Wikipedia:Neuron_migration	hp.json	neuron guidance|neuron chemotaxis|neuronal migration	http://purl.obolibrary.org/obo/GO_0001764		
GO:0060082	biolink:NamedThing	eye blink reflex			hp.json		http://purl.obolibrary.org/obo/GO_0060082		
GO:0060083	biolink:BiologicalProcess	smooth muscle contraction involved in micturition	The process leading to shortening and/or development of tension in the urinary bladder smooth muscle tissue involved in the expulsion urine from the body.		hp.json	smooth muscle contraction involved in urination|urinary bladder smooth muscle contraction involved in micturition	http://purl.obolibrary.org/obo/GO_0060083		
GO:0060084	biolink:BiologicalProcess	synaptic transmission involved in micturition	The process of communication from a neuron to a smooth muscle in the bladder that contributes to the expulsion of urine from the body.		hp.json	synaptic transmission involved in urination	http://purl.obolibrary.org/obo/GO_0060084		
HP:0010816	biolink:PhenotypicFeature	Epidermal nevus	Epidermal naevi are due to an overgrowth of the epidermis and may be present at birth (50%) or develop during childhood.	SNOMEDCT_US:239107007|UMLS:C0334082|MSH:C580062|SNOMEDCT_US:25201003	hp.json	Epidermal nevi	http://purl.obolibrary.org/obo/HP_0010816		
HP:0009838	biolink:PhenotypicFeature	Curved distal phalanges of the hand		UMLS:C4024188	hp.json	Curved outermost finger bone of the hand	http://purl.obolibrary.org/obo/HP_0009838		
GO:0060089	biolink:MolecularActivity	molecular transducer activity	A compound molecular function in which an effector function is controlled by one or more regulatory components.		hp.json		http://purl.obolibrary.org/obo/GO_0060089		goslim_generic|gocheck_do_not_manually_annotate|goslim_pir
HP:0010815	biolink:PhenotypicFeature	Nevus sebaceous	A congenital, hairless plaque consisting of overgrown epidermis, sebaceous glands, hair follicles, apocrine glands and connective tissue. They are a variant of epidermal naevi. Sebaceous naevi most often appear on the scalp, but they may also arise on the face, neck or forehead. At birth, a sevaceous nevus typically appears as a solitary, smooth, yellow-orange hairless patch. Sebaceous naevi become more pronounced around adolescence, often appearing bumpy, warty or scaly.	UMLS:C3854181|SNOMEDCT_US:707136009|MSH:D054000|SNOMEDCT_US:52298009|SNOMEDCT_US:239112008	hp.json	Naevus sebaceous|Sebaceous mole|Sebaceous naevus|Sebaceous nevus|Organoid nevus	http://purl.obolibrary.org/obo/HP_0010815		
HP:0009837	biolink:PhenotypicFeature	Bullet-shaped distal phalanges of the hand	Short and wide distal phalanges that taper distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4024189	hp.json	Bullet-shaped outermost finger bone of the hand	http://purl.obolibrary.org/obo/HP_0009837		
HP:0010814	biolink:PhenotypicFeature	Abnormal position of hair whorl	Hair growth from a single point on the scalp in any location other than lateral to the midline and close to the vertex of the skull.	UMLS:C4023694	hp.json	Abnormal location of hair swirl|Abnormal position of hair whorl	http://purl.obolibrary.org/obo/HP_0010814		hposlim_core
HP:0009839	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanges of the hand		UMLS:C1849547	hp.json	Osteolytic defects of the outermost finger bone of the hand|Acroosteolysis of distal phalanges|Acro-osteolysis of distal phalanges	http://purl.obolibrary.org/obo/HP_0009839		
HP:0010813	biolink:PhenotypicFeature	Abnormal number of hair whorls	More than two clockwise hair whorls.	UMLS:C4023695	hp.json	Extra hair whorl|Abnormal number of hair swirls|Extra hair swirls|Supernumary hair swirls|Double crown (hair whorls)|Supernumary hair whorl|Abnormal number of hair whorls	http://purl.obolibrary.org/obo/HP_0010813		hposlim_core
HP:0009834	biolink:PhenotypicFeature	Abnormal proximal phalanx morphology of the hand		UMLS:C4024190	hp.json	Abnormality of the proximal phalanges of the hand|Abnormality of the innermost finger bones of the hand	http://purl.obolibrary.org/obo/HP_0009834		
HP:0010812	biolink:PhenotypicFeature	Short uvula	Decreased length of the uvula.	UMLS:C1401781	hp.json	Blunt uvula|Short palatine uvula|Hypoplastic uvula	http://purl.obolibrary.org/obo/HP_0010812		
HP:0009833	biolink:PhenotypicFeature	Abnormal middle phalanx morphology of the hand	An anomaly of middle phalanx of finger.	UMLS:C4024191	hp.json	Abnormality of the middle phalanges of the hand|Abnormality of the middle finger bones of the hand	http://purl.obolibrary.org/obo/HP_0009833		
HP:0010811	biolink:PhenotypicFeature	Narrow uvula	Decreased width of the uvula.	UMLS:C4023696	hp.json	Narrow palatine uvula|Thin uvula	http://purl.obolibrary.org/obo/HP_0010811		hposlim_core
HP:0009836	biolink:PhenotypicFeature	Broad distal phalanx of finger	Abnormally wide (broad) distal phalanx of finger.	UMLS:C1850630	hp.json	Spatulate terminal phalanges|Broad, square ends of distal phalanges|Broad outermost finger bone|Broad distal phalanges|Broad terminal phalanges|Broad distal phalanges of the hand|Broad distal phalanx	http://purl.obolibrary.org/obo/HP_0009836		
HP:0010810	biolink:PhenotypicFeature	Long uvula	Increased length of the uvula.	UMLS:C4023697|UMLS:C4280362	hp.json	Hyperplasia of uvula|Long palatine uvula|Elongated uvula	http://purl.obolibrary.org/obo/HP_0010810		hposlim_core
HP:0009835	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanges of the hand	Absence or underdevelopment of the distal phalanges.	UMLS:C1861336	hp.json	Aplastic/hypoplastic distal phalanges|Absent/underdeveloped outermost finger bone of the hand|Small or absent distal phalanges|Hypoplastic to absent terminal phalanges|Absent/hypoplastic distal phalanges|Aplasia/Hypoplasia of the distal phalanges|Hypoplastic/aplastic distal phalanx|Absent/small outermost finger bone of the hand|Hypoplastic/aplastic distal phalanges	http://purl.obolibrary.org/obo/HP_0009835		
HP:0009830	biolink:PhenotypicFeature	Peripheral neuropathy	Peripheral neuropathy is a general term for any disorder of the peripheral nervous system. The main clinical features used to classify peripheral neuropathy are distribution, type (mainly demyelinating versus mainly axonal), duration, and course.	UMLS:C0031117|SNOMEDCT_US:302226006|SNOMEDCT_US:386033004|UMLS:C0442874|SNOMEDCT_US:42658009|MSH:D010523	hp.json	Peripheral nerve damage|Neuropathy|Peripheral neuritis	http://purl.obolibrary.org/obo/HP_0009830		
HP:0009832	biolink:PhenotypicFeature	Abnormal distal phalanx morphology of finger	Any anomaly of distal phalanx of finger.	UMLS:C4021385	hp.json	Abnormality of the outermost finger bone|Abnormal terminal phalanges of the hand|Abnormality of the distal phalanges of the hand|Abnormality of the distal phalanx of finger	http://purl.obolibrary.org/obo/HP_0009832		
HP:0009831	biolink:PhenotypicFeature	Mononeuropathy	A focal lesion of a single peripheral nerve. Damage to a sensory nerve is accompanied by sensory impairment of all modalities in the affected anatomic distribution.	MSH:D020422|SNOMEDCT_US:128189008|UMLS:C0494491	hp.json	Single damaged nerve	http://purl.obolibrary.org/obo/HP_0009831		
GO:0001767	biolink:BiologicalProcess	establishment of lymphocyte polarity	The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.		hp.json	lymphocyte polarization	http://purl.obolibrary.org/obo/GO_0001767		
HP:0010819	biolink:PhenotypicFeature	Atonic seizure	Atonic seizure is a type of motor seizure characterized by a sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic event lasting about 1 to 2 seconds, involving head, trunk, jaw, or limb musculature.	SNOMEDCT_US:189198006|UMLS:C1836509|SNOMEDCT_US:42365007|UMLS:C0270846	hp.json	Astatic seizure|Astatic seizures|Drop seizures|Sudden loss of muscle tone|Hypotonic seizure|Hypotonic seizures|Drop attacks|Atonic seizures	http://purl.obolibrary.org/obo/HP_0010819		
GO:0001768	biolink:BiologicalProcess	establishment of T cell polarity	The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.		hp.json	establishment of T lymphocyte polarity|establishment of T-cell polarity|T lymphocyte polarization|T-cell polarization|establishment of T-lymphocyte polarity|T cell polarization	http://purl.obolibrary.org/obo/GO_0001768		
HP:0010818	biolink:PhenotypicFeature	Generalized tonic seizure	A generalized tonic seizure is a type of generalized motor seizure characterised by bilateral limb stiffening or elevation, often with neck stiffening without a subsequent clonic phase. The tonic activity can be a sustained abnormal posture, either in extension or flexion, sometimes accompanied by tremor of the extremities.	UMLS:C1836508	hp.json	Generalised tonic seizure|Generalised tonic seizures|Generalized hypertonic seizure|Generalized tonic seizures|Hypertonic seizures|Generalised hypertonic seizure	http://purl.obolibrary.org/obo/HP_0010818		
HP:0010817	biolink:PhenotypicFeature	Linear nevus sebaceous	A type of nevus sebaceous with a linear form, raised borders and yellowish color.	UMLS:C3854181|SNOMEDCT_US:707136009|MSH:D054000|SNOMEDCT_US:52298009|SNOMEDCT_US:239112008	hp.json		http://purl.obolibrary.org/obo/HP_0010817		
HP:0020208	biolink:PhenotypicFeature	Eating-induced seizure	A seizure precipitated by aspects of anticipating food, eating itself, or the post-prandial period.		hp.json		http://purl.obolibrary.org/obo/HP_0020208		
CHEBI:50699	biolink:ChemicalSubstance	oligosaccharide	A compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues.	KEGG:C00930	hp.json	O-glycosylglycoside|oligosaccharides|oligosacarido|oligosacaridos|O-glycosylglycosides|Oligosaccharide	http://purl.obolibrary.org/obo/CHEBI_50699		3_STAR
HP:0020207	biolink:PhenotypicFeature	Reflex seizure	Seizures precipitated by exogenous stimuli.		hp.json		http://purl.obolibrary.org/obo/HP_0020207		
HP:0009890	biolink:PhenotypicFeature	High anterior hairline	Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD above the mean. Alternatively, an apparently increased distance between the hairline and the glabella.	UMLS:C3276036	hp.json	High frontal hairline	http://purl.obolibrary.org/obo/HP_0009890		hposlim_core
HP:0020209	biolink:PhenotypicFeature	Hot water-induced seizure	A seizure precipitated by pouring cupfuls of very hot water (40 to 50 degrees Celsius) in rapid succession over the head. Bathing in this manner is the most common trigger.		hp.json		http://purl.obolibrary.org/obo/HP_0020209		
CHEBI:23079	biolink:ChemicalSubstance	cerebroside			hp.json		http://purl.obolibrary.org/obo/CHEBI_23079		
HP:0020204	biolink:PhenotypicFeature	Tubulointerstitial bacterial infiltration	Tubulointerstitial infiltration of bacteria identified on routine and/or special (Brown-Hopps) stains.		hp.json	Renal tubulointerstitial bacterial organisms	http://purl.obolibrary.org/obo/HP_0020204		
HP:0020203	biolink:PhenotypicFeature	Z-band streaming	Streaming or smearing of the Z band, which is then no longer confined to a narrow zone which bisects the I band. The Z disc may extend across the I band or the entire sarcomere in a zigzag manner. Focal thickening, smudging, and blurring of the Z band takes place concurrently. Myofibrillar disorganization is a frequent but not invariable accompanying change.		hp.json		http://purl.obolibrary.org/obo/HP_0020203		
UBERON:0000414	biolink:AnatomicalEntity	mucous gland	A gland in which the principal secretory cells are mucus secreting cells.	BTO:0001979|AAO:0010601|EMAPA:37913|FMA:62888|Wikipedia:Mucous_gland	hp.json	glandula mucosa|glandula mucosa|muciparous gland|mucus-secreting gland|mucus gland|mucous secreting gland	http://purl.obolibrary.org/obo/UBERON_0000414		organ_slim
UBERON:0000415	biolink:AnatomicalEntity	artery wall	An anatomical wall that is part of an artery [Automatically generated definition].	FMA:14155|galen:ArterialWall|BTO:0002009	hp.json	wall of artery|arterial wall	http://purl.obolibrary.org/obo/UBERON_0000415		
HP:0020206	biolink:PhenotypicFeature	Simple ear	The pinna has fewer folds and grooves than usual.		hp.json		http://purl.obolibrary.org/obo/HP_0020206		
HP:0020205	biolink:PhenotypicFeature	Tubulointerstitial fungal infiltration	Tubulointerstitial infiltration of yeast or hyphal-microrganisms identified on routine and/or special (PAS, silver) stains.		hp.json	Renal tubulointerstitial fungal organisms	http://purl.obolibrary.org/obo/HP_0020205		
HP:0010885	biolink:PhenotypicFeature	Avascular necrosis	A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply.	SNOMEDCT_US:72756009|SNOMEDCT_US:398199007|SNOMEDCT_US:240196003|UMLS:C0085660|MSH:D010020|UMLS:C0877326|UMLS:C0520474|UMLS:C0029445	hp.json	Ischaemic bone necrosis|Death of bone due to decreased blood supply|Aseptic necrosis|Bone infarction|Aseptic bone necrosis|Ischemic bone necrosis|Osteonecrosis|Osteochondronecrosis	http://purl.obolibrary.org/obo/HP_0010885		
HP:0010884	biolink:PhenotypicFeature	Acromelia	Shortening of the extremities affecting primarily the distal parts of the limbs (hands and feet) in relation to the other segments of the limbs.	UMLS:C4023675	hp.json		http://purl.obolibrary.org/obo/HP_0010884		hposlim_core
GO:0072091	biolink:BiologicalProcess	regulation of stem cell proliferation	Any process that modulates the frequency, rate or extent of stem cell proliferation. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.		hp.json		http://purl.obolibrary.org/obo/GO_0072091		
HP:0010883	biolink:PhenotypicFeature	Aortic valve atresia	A congenital disorder of the aortic valve in which the orifice of the valve fails to develop.	UMLS:C0265843|SNOMEDCT_US:51442005	hp.json	Aortic atresia	http://purl.obolibrary.org/obo/HP_0010883		
HP:0010882	biolink:PhenotypicFeature	Pulmonary valve atresia	A congenital disorder of the pulmonary valve in which the orifice of the valve fails to develop.	SNOMEDCT_US:204342004|SNOMEDCT_US:448564004|UMLS:C0242855|MSH:D018633|Fyler:1001	hp.json		http://purl.obolibrary.org/obo/HP_0010882		
CHEBI:47042	biolink:ChemicalSubstance	hydroxycalciol			hp.json	hydroxycholecalciferols|hydroxycalciol|hydroxycalciols|hydroxycholecalciferol	http://purl.obolibrary.org/obo/CHEBI_47042		3_STAR
HP:0010881	biolink:PhenotypicFeature	Abnormality of the umbilical cord	An abnormality of the umbilical cord, which is the cord connecting the developing embryo or fetus to the placenta.	UMLS:C0266785|SNOMEDCT_US:90009001	hp.json	Umbilical cord issue	http://purl.obolibrary.org/obo/HP_0010881		
HP:0010880	biolink:PhenotypicFeature	Increased nuchal translucency	Nuchal translucency is the sonographic appearance of subcutaneous accumulation of liquid in the back of the fetal neck in the first trimester of pregnancy (11-14 gestational weeks of pregnancy).	UMLS:C4023676	hp.json		http://purl.obolibrary.org/obo/HP_0010880		
CHEBI:23075	biolink:ChemicalSubstance	glycotetraosylceramide	An oligoglycosylceramide consisting of a glycotetraosyl moiety attached to the ceramide oxygen with an unspecified N-acyl substituent attached to the ceramide nitrogen.		hp.json	glycotetraosylceramides	http://purl.obolibrary.org/obo/CHEBI_23075		3_STAR
HP:0010889	biolink:PhenotypicFeature	Morbus Kienboeck	Morbus Kienboeck is a Juvenile aseptic necrosis affecting the Os lunatum.	SNOMEDCT_US:360466009|MSH:D010020|SNOMEDCT_US:84062004|SNOMEDCT_US:367356000|UMLS:C0022682	hp.json	Kienboeck's disease|Lunatomalacia|Kienböck's disease	http://purl.obolibrary.org/obo/HP_0010889		
HP:0009889	biolink:PhenotypicFeature	Localized hirsutism	Abnormally increased hair growth with a localized distribution.	UMLS:C4024170	hp.json	Localized abnormal hair growth|Localised abnormal hair growth|Localised hirsutism	http://purl.obolibrary.org/obo/HP_0009889		
HP:0007227	biolink:PhenotypicFeature	Macrogyria	Increased size of cerebral gyri, often associated with a moderate reduction in the number of sulci of the cerebrum.	SNOMEDCT_US:23024003|MSH:D054082|UMLS:C0266483	hp.json		http://purl.obolibrary.org/obo/HP_0007227		
HP:0009888	biolink:PhenotypicFeature	Abnormality of secondary sexual hair	Abnormality of the growth of secondary sexual hair, which normally ensues during puberty. In males, secondary sexual hair usually comprises body hair, including underarm, abdominal, chest, and pubic hair. In females, secondary sexual hair usually comprises a lesser degree of body hair, most prominently underarm and pubic hair.	UMLS:C4024171	hp.json	Abnormality of secondary sexual hair	http://purl.obolibrary.org/obo/HP_0009888		
HP:0010888	biolink:PhenotypicFeature	Morbus Koehler	Morbus Koehler is a Juvenile aseptic necrosis affecting the Os naviculare pedis.	UMLS:C4023674	hp.json		http://purl.obolibrary.org/obo/HP_0010888		
HP:0010886	biolink:PhenotypicFeature	Osteochondritis dissecans	A joint disorder caused by blood deprivation in the subchondral bone causing the subchondral bone to die in a process called avascular necrosis. The bone is then reabsorbed by the body, leaving the articular cartilage it supported prone to damage. The result is fragmentation (dissection) of both cartilage and bone, and the free movement of these osteochondral fragments within the joint space, causing pain and further damage.	UMLS:C0029421|SNOMEDCT_US:82562007|MSH:D010008	hp.json	Osteochondrosis dissecans	http://purl.obolibrary.org/obo/HP_0010886		
HP:0007229	biolink:PhenotypicFeature	Intracerebral periventricular calcifications	The presence of calcium deposition in the cerebral white matter surrounding the cerebral ventricles.	UMLS:C1837246	hp.json		http://purl.obolibrary.org/obo/HP_0007229		
HP:0020200	biolink:PhenotypicFeature	Increased circulating 18-hydroxycortisone level	An abnormally elevated concentration of 18-Hydroxycorticosterone level in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0020200		
HP:0009885	biolink:PhenotypicFeature	obsolete Prenatal short stature			hp.json		http://purl.obolibrary.org/obo/HP_0009885		
HP:0009884	biolink:PhenotypicFeature	Tapered distal phalanges of finger	A reduction in diameter of the distal phalanx of finger towards the distal end.	UMLS:C1969237	hp.json	Tapered distal phalanges|Tapered outermost finger bone|Tapered distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009884		
HP:0020202	biolink:PhenotypicFeature	Abnormal Z disc morphology	Any structural anomaly of the Z disc, which is the platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.		hp.json		http://purl.obolibrary.org/obo/HP_0020202		
HP:0009887	biolink:PhenotypicFeature	Abnormality of hair pigmentation	An abnormality of hair pigmentation (color).	UMLS:C4024172	hp.json	Abnormality of hair colour|Abnormality of hair color|Abnormality of hair pigmentation	http://purl.obolibrary.org/obo/HP_0009887		
UBERON:0000423	biolink:AnatomicalEntity	eccrine sweat gland	A merocrine, unbranched, unbranched, coiled, tubular gland sweat gland. In humans, distributed over almost all of the body surface, and promote cooling by evaporation of their secretion.	FMA:59154|BTO:0002323|GAID:945|NCIT:C32490|MESH:D004439|MA:0003039|UMLS:C0013492	hp.json	merocrine sweat gland|glandula sudorifera merocrina|eccrine gland|glandula sudorifera eccrina	http://purl.obolibrary.org/obo/UBERON_0000423		organ_slim|pheno_slim|human_reference_atlas
HP:0009886	biolink:PhenotypicFeature	Trichorrhexis nodosa	Trichorrhexis nodosa is the formation of nodes along the hair shaft through which breakage readily occurs. It is thus a focal defect in the hair fiber that is characterized by thickening or weak points (nodes) that cause the hair to break off easily. The result is defective, abnormally fragile hair.	UMLS:C0263485|SNOMEDCT_US:22486004|SNOMEDCT_US:238736006	hp.json		http://purl.obolibrary.org/obo/HP_0009886		
HP:0020201	biolink:PhenotypicFeature	Abnormal sarcomere morphology	Any structural anomaly of the sarcomere, which is unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.		hp.json		http://purl.obolibrary.org/obo/HP_0020201		
HP:0009881	biolink:PhenotypicFeature	Aplasia of the distal phalanges of the hand		UMLS:C4024173	hp.json	Aplasia of outermost hand bone|Absent outermost hand bone|Absent distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009881		
HP:0009880	biolink:PhenotypicFeature	Broad distal phalanges of all fingers	Abnormally wide (broad) distal phalanx of finger of all fingers.	UMLS:C4024174	hp.json	Broad outermost hand bones	http://purl.obolibrary.org/obo/HP_0009880		
HP:0007220	biolink:PhenotypicFeature	Demyelinating motor neuropathy	Demyelination of peripheral motor nerves.	UMLS:C1969462	hp.json		http://purl.obolibrary.org/obo/HP_0007220		
HP:0009883	biolink:PhenotypicFeature	Duplication of the distal phalanx of hand	This term applies if one or more of the distal phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.	UMLS:C1849343	hp.json	Partial/complete duplication of the distal phalanges of the hand|Bifid terminal phalanges|Notched outermost bone of hand|Duplication of the outermost bone of hand	http://purl.obolibrary.org/obo/HP_0009883		
HP:0009882	biolink:PhenotypicFeature	Short distal phalanx of finger	Short distance from the end of the finger to the most distal interphalangeal crease or the distal interphalangeal joint flexion point. That is, hypoplasia of one or more of the distal phalanx of finger.	UMLS:C1839829	hp.json	Hypoplasia of the distal phalanges of the hand|Short distal phalanges|Brachytelophalangy|Hypoplasic terminal phalanges|Hypoplastic distal phalanges|Hypoplasia of the distal phalanges|Terminal phalangeal hypoplasia of hand|Hypoplastic terminal phalanges|Short outermost finger bone|Distal phalangeal hypoplasia	http://purl.obolibrary.org/obo/HP_0009882		hposlim_core
HP:0007221	biolink:PhenotypicFeature	Progressive truncal ataxia		UMLS:C1849143	hp.json		http://purl.obolibrary.org/obo/HP_0007221		
GO:0072089	biolink:BiologicalProcess	stem cell proliferation	The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.		hp.json		http://purl.obolibrary.org/obo/GO_0072089		
GO:0001743	biolink:BiologicalProcess	lens placode formation	The initial developmental process that will lead to the formation of an eye.		hp.json	optic placode formation	http://purl.obolibrary.org/obo/GO_0001743		
UBERON:0000409	biolink:AnatomicalEntity	serous gland	A gland in which the principal secretory cells are serous secreting cells.	BTO:0001837|FMA:62889|EMAPA:37950|Wikipedia:Serous_gland	hp.json		http://purl.obolibrary.org/obo/UBERON_0000409		organ_slim|pheno_slim
UBERON:0000402	biolink:AnatomicalEntity	nasal vestibule	The nasal vestibule is the most anterior part of the nasal cavity. It's enclosed by the cartilages of nose and lined by the same epithelium of the skin. The other part of the nasal cavity, which is lined by the respiratory epithelium, is called nasal cavity proper. [WP,unvetted].	CALOHA:TS-0660|BTO:0001761|FMA:59644	hp.json	vestibulum nasi|vestibulum nasale|vestibulum nasi|vestibular part of nasal cavity	http://purl.obolibrary.org/obo/UBERON_0000402		
UBERON:0000403	biolink:AnatomicalEntity	scalp	The outer covering of the calvaria. It is composed of several layers: SKIN; subcutaneous connective tissue; the occipitofrontal muscle which includes the tendonous galea aponeurotica; Loose connective tissue; and the pericranium (the PERIOSTEUM of the SKULL).	UMLS:C0036270|MESH:D012535|GAID:80|FMA:46494|galen:Scalp|NCIT:C89807|BTO:0001809|CALOHA:TS-0896|EMAPA:37949|OpenCyc:Mx4rwNtaz5wpEbGdrcN5Y29ycA	hp.json	scalpus	http://purl.obolibrary.org/obo/UBERON_0000403		pheno_slim
CHEBI:50689	biolink:ChemicalSubstance	reproductive control drug	A substance used either in the prevention or facilitation of pregnancy.		hp.json	reproductive control agent|reproductive control drugs	http://purl.obolibrary.org/obo/CHEBI_50689		3_STAR
HP:0010874	biolink:PhenotypicFeature	Tendon xanthomatosis	The presence of xanthomas (intra-and extra-cellular accumulations of cholesterol) extensor tendons (typically over knuckles, Achilles tendon, knee, and elbows).	SNOMEDCT_US:69880002|UMLS:C0221253	hp.json	Tendon xanthomas	http://purl.obolibrary.org/obo/HP_0010874		
HP:0010873	biolink:PhenotypicFeature	Cervical spinal cord atrophy	Atrophy of the cervical segment of the spinal cord.	UMLS:C0742191	hp.json		http://purl.obolibrary.org/obo/HP_0010873		
HP:0010872	biolink:PhenotypicFeature	T-wave inversion	An inversion of the T-wave (which is normally positive).	UMLS:C0520888|SNOMEDCT_US:59931005	hp.json	EKG: T-wave inversion	http://purl.obolibrary.org/obo/HP_0010872		
HP:0010871	biolink:PhenotypicFeature	Sensory ataxia	Incoordination of movement caused by a deficit in the sensory nervous system. Sensory ataxia can be distinguished from cerebellar ataxia by asking the patient to close his or her eyes. Persons with cerebellar ataxia show only a minimal worsening of symptoms, whereas persons with sensory ataxia show a marked worsening of symptoms.	SNOMEDCT_US:69131009|MSH:D001259|SNOMEDCT_US:445458007|UMLS:C0037921|UMLS:C0240991	hp.json	Afferent ataxia|Spinal ataxia|Ataxia, sensory	http://purl.obolibrary.org/obo/HP_0010871		
HP:0010879	biolink:PhenotypicFeature	Postnatal cystic hygroma		UMLS:C4023677	hp.json		http://purl.obolibrary.org/obo/HP_0010879		
HP:0010878	biolink:PhenotypicFeature	Fetal cystic hygroma	The presence during the prenatal period of a cystic mass with multiple septa with multiple, asymmetric, thin-walled cysts near the posterior aspect of the neck. Fetal cystic hygroma can be defined as nuchal translucency with or without septations measuring greater than 3.0 mm. Increased NT refers to a measurement above the 95th centile, and the term is used irrespective of whether the collection of fluid is septated or not, and whether it is confined to the neck or envelopes the whole fetus. After 14 weeks, increased NT usually resolves, but in some cases it evolves into nuchal edema or cystic hygromas.	MSH:C537852|UMLS:C0948242	hp.json	Foetal cystic hygroma	http://purl.obolibrary.org/obo/HP_0010878		
HP:0010877	biolink:PhenotypicFeature	Monocular strabismus	A type of strabismus in which the fixating eye is always the same one, while the other eye is constantly deviated. Monocular strabismus is to be distinguished from alternating strabismus, in which either of the eyes 'squints' at different times.	UMLS:C4023678	hp.json	Unilateral strabismus	http://purl.obolibrary.org/obo/HP_0010877		
HP:0009899	biolink:PhenotypicFeature	Prominent crus of helix	The presence of an abnormally prominent of the crus of the helix. That is, development of the crus helix to the same degree as an average antihelix stem or helix.	UMLS:C4021377	hp.json	Hyperplastic helix crus|Hypertrophic helix crus|Helix, crus, prominent|Abnormal prominence of the crus of the ear	http://purl.obolibrary.org/obo/HP_0009899		hposlim_core
HP:0007238	biolink:PhenotypicFeature	Nonarteriosclerotic cerebral calcification		UMLS:C4021579	hp.json	Cerebral calcification, nonarteriosclerotic	http://purl.obolibrary.org/obo/HP_0007238		
HP:0007239	biolink:PhenotypicFeature	Congenital encephalopathy		UMLS:C4024917	hp.json		http://purl.obolibrary.org/obo/HP_0007239		
HP:0010876	biolink:PhenotypicFeature	Abnormal circulating protein concentration	An abnormal level of a circulating protein in the blood.	UMLS:C4020764|UMLS:C4023679|UMLS:C4020763	hp.json	Abnormal circulating protein level|Serum protein abnormality|Blood protein disease|Abnormality of circulating protein level	http://purl.obolibrary.org/obo/HP_0010876		
HP:0010875	biolink:PhenotypicFeature	Chaddock reflex	A diagnostic reflex elicited by stimulation of the skin over the surface of the lateral malleolus of the foot. The Chaddock refelx is present if there is extension of one or more or all of the toes with or without fanning of them when the external inframalleolar skin is stimulated. The Chaddock sign, similar to the Babinski sign, is taken to be an indication of disease of the spinocortical (pyramidal) tract.	SNOMEDCT_US:413813004|UMLS:C1531651	hp.json		http://purl.obolibrary.org/obo/HP_0010875		
HP:0009896	biolink:PhenotypicFeature	Abnormal antitragus morphology	An abnormality of the antitragus, which is a small tubercle opposite to the tragus of the ear. The antitragus and the tragus are separated by the intertragic notch.	UMLS:C4024167	hp.json		http://purl.obolibrary.org/obo/HP_0009896		hposlim_core
HP:0007233	biolink:PhenotypicFeature	Clusters of axonal regeneration	Groups of small caliber axons in peripheral nerve biospies indicative of axonal regeneration.	UMLS:C1843169	hp.json		http://purl.obolibrary.org/obo/HP_0007233		
UBERON:0000410	biolink:AnatomicalEntity	bronchial mucosa	A mucosa that is part of a bronchus [Automatically generated definition].	BTO:0001846|FMA:62652	hp.json	bronchial trunk organ mucosa|bronchi mucosa|mucosa of bronchus|tunica mucosa bronchi|bronchi organ mucosa|organ mucosa of bronchus|mucous membrane of bronchus|mucous membrane of bronchi|bronchi mucosa of organ|organ mucosa of bronchi|bronchial trunk mucosa of organ|mucosa of bronchi|organ mucosa of bronchial trunk|mucous membrane of bronchial trunk|mucosa of bronchial trunk|bronchus mucosa of organ|bronchi mucous membrane|mucous membrane of bronchus|mucosa of organ of bronchi|mucosa of organ of bronchial trunk|bronchial trunk mucous membrane|bronchus mucous membrane|mucosa of organ of bronchus|bronchus mucosa|bronchus organ mucosa|bronchial trunk mucosa	http://purl.obolibrary.org/obo/UBERON_0000410		
HP:0009895	biolink:PhenotypicFeature	Abnormality of the crus of the helix	An abnormality of the crus of the helix, which is the horizontal piece of cartilage located outside the ear canal that divides the upper and lower parts of the ear.	UMLS:C4021380	hp.json	Abnormality of the crus of the ear	http://purl.obolibrary.org/obo/HP_0009895		
HP:0009898	biolink:PhenotypicFeature	Underdeveloped crus of the helix	Developmental hypoplasia of the crus of the helix. That is, flatter and/or shorter crus helix than average.	UMLS:C4021378	hp.json	Underdeveloped crus of the ear|Hypoplasia of the crus of the ear	http://purl.obolibrary.org/obo/HP_0009898		hposlim_core
HP:0009897	biolink:PhenotypicFeature	Horizontal crus of helix	An abnormal horizontal axis orientation of the crus of the helix. That is, the main axis of the crus of the helix is perpendicular to the medial longitudinal axis of the ear, instead of sloping inferoposteriorly.	UMLS:C4021379	hp.json	Helix, crus, horizontal|Horizontal orientation of the ear crus|Railroad track sign|Horizontal orientation of the crus of helix|Railroad track ears	http://purl.obolibrary.org/obo/HP_0009897		hposlim_core
HP:0007236	biolink:PhenotypicFeature	Recurrent subcortical infarcts		UMLS:C4024918	hp.json		http://purl.obolibrary.org/obo/HP_0007236		
HP:0009892	biolink:PhenotypicFeature	Anotia	Complete absence of any auricular structures.	UMLS:C0702139|UMLS:C1408788|SNOMEDCT_US:57436000|MSH:D065817	hp.json	Congenital absence of external ear|Absent ear|Absent ears	http://purl.obolibrary.org/obo/HP_0009892		hposlim_core
GO:0001745	biolink:BiologicalProcess	compound eye morphogenesis	The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.		hp.json	insect-type retina morphogenesis	http://purl.obolibrary.org/obo/GO_0001745		
HP:0009891	biolink:PhenotypicFeature	Underdeveloped supraorbital ridges	Flatness of the supraorbital portion of the frontal bones.	UMLS:C4020777|UMLS:C1861869	hp.json	Hypoplasia of supraorbital margins|Depressed supraorbital margins|Flattened bony protrusion above eyes|Hypoplasia of the supraorbital ridges|Depressed supraorbital ridge|Underdeveloped brows|Hypoplastic supraorbital ridges|Shallow supraorbital ridge|Shallow orbital ridges|Flat supraorbital margins|Flat supraorbital ridge	http://purl.obolibrary.org/obo/HP_0009891		hposlim_core
HP:0007230	biolink:PhenotypicFeature	Decreased distal sensory nerve action potential	A reduction in the amplitude of sensory nerve action potential in distal nerve segments. This feature is measured by nerve conduction studies.	UMLS:C4024920	hp.json		http://purl.obolibrary.org/obo/HP_0007230		
HP:0009894	biolink:PhenotypicFeature	Thickened ears	Increased thickness of the external ear.	UMLS:C4024168	hp.json	Thickened ears	http://purl.obolibrary.org/obo/HP_0009894		hposlim_core
HP:0009893	biolink:PhenotypicFeature	Telangiectasia of the ear	The presence of telangiectasia of the ear.	UMLS:C4024169	hp.json		http://purl.obolibrary.org/obo/HP_0009893		hposlim_core
HP:0007232	biolink:PhenotypicFeature	Spinocerebellar tract disease in lower limbs		UMLS:C4024919	hp.json		http://purl.obolibrary.org/obo/HP_0007232		
HP:0010863	biolink:PhenotypicFeature	Receptive language delay	A delay in the acquisition of the ability to understand the speech of others.	SNOMEDCT_US:229736005|UMLS:C0454642	hp.json		http://purl.obolibrary.org/obo/HP_0010863		
HP:0010862	biolink:PhenotypicFeature	Delayed fine motor development	A type of motor delay characterized by a delay in acquiring the ability to control the fingers and hands.	UMLS:C4023681	hp.json		http://purl.obolibrary.org/obo/HP_0010862		
HP:0010861	biolink:PhenotypicFeature	Incomplete breech presentation	A kind of breech presentation in which one or both hips are extended and one or both of the fetus' feet are pointing down and entering the birth canal.	MSH:D001946|UMLS:C0426146|SNOMEDCT_US:38049006	hp.json		http://purl.obolibrary.org/obo/HP_0010861		
HP:0010860	biolink:PhenotypicFeature	Complete breech presentation	A kind of breech presentation in which the hips are flexed and the knees are flexed.	UMLS:C0233283|SNOMEDCT_US:49168004|MSH:D001946	hp.json		http://purl.obolibrary.org/obo/HP_0010860		
HP:0007208	biolink:PhenotypicFeature	Irregular myelin loops	Presence of irregular redundant loops of focally folded myelin in a peripheral nerve.	UMLS:C4024922	hp.json		http://purl.obolibrary.org/obo/HP_0007208		
HP:0007209	biolink:PhenotypicFeature	Facial paralysis	Complete loss of ability to move facial muscles innervated by the facial nerve (i.e., the seventh cranial nerve).	UMLS:C0427055|MSH:D005158|UMLS:C0015469|SNOMEDCT_US:280816001|SNOMEDCT_US:95666008	hp.json	Facial paralysis|Facial paresis	http://purl.obolibrary.org/obo/HP_0007209		hposlim_core
HP:0010869	biolink:PhenotypicFeature	Asynergia	A type of dyssynergy characterized by the lack of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed.	SNOMEDCT_US:77743009|UMLS:C0234355	hp.json		http://purl.obolibrary.org/obo/HP_0010869		
HP:0010868	biolink:PhenotypicFeature	Ocular dyssynergia	A type of dyssynergia affecting eye movements and characterized by the inability to smoothly follow a visual target across the visual field.	UMLS:C4023680	hp.json		http://purl.obolibrary.org/obo/HP_0010868		
HP:0007204	biolink:PhenotypicFeature	Diffuse white matter abnormalities		UMLS:C4024923	hp.json		http://purl.obolibrary.org/obo/HP_0007204		
HP:0010867	biolink:PhenotypicFeature	Dyssynergia	A type of ataxia characterized by the impairment of the ability to smoothly perform the elements of a voluntary movement in the appropriate order and speed. With dyssynergia, a voluntary movement appears broken down into its component parts.	UMLS:C0004134|SNOMEDCT_US:39384006|MSH:D001259|SNOMEDCT_US:20262006	hp.json		http://purl.obolibrary.org/obo/HP_0010867		
HP:0010866	biolink:PhenotypicFeature	Abdominal wall defect	An incomplete closure of the abdominal wall.	UMLS:C0238577	hp.json	Abdominal wall defect|Congenital anterior abdominal wall defect	http://purl.obolibrary.org/obo/HP_0010866		
HP:0007206	biolink:PhenotypicFeature	Hemimegalencephaly	Enlargement of all or parts of one cerebral hemisphere.	UMLS:C0431391|MSH:D065705|SNOMEDCT_US:253170008	hp.json		http://purl.obolibrary.org/obo/HP_0007206		
HP:0010865	biolink:PhenotypicFeature	Oppositional defiant disorder	An enduring pattern of uncooperative, defiant, and hostile behavior toward authority figures that does not involve major antisocial violations, is not accounted for by the child's developmental stage, and results in significant functional impairment. A certain level of oppositional behavior is common in children and adolescents.	SNOMEDCT_US:18941000|UMLS:C0029121|MSH:D019958	hp.json		http://purl.obolibrary.org/obo/HP_0010865		
HP:0010864	biolink:PhenotypicFeature	Intellectual disability, severe	Severe mental retardation is defined as an intelligence quotient (IQ) in the range of 20-34.	SNOMEDCT_US:40700009|UMLS:C0036857	hp.json	Early and severe mental retardation|Severe mental retardation|Mental retardation, severe|Intellectual disability, severe	http://purl.obolibrary.org/obo/HP_0010864		
HP:0007207	biolink:PhenotypicFeature	Photosensitive tonic-clonic seizure	Generalized-onset tonic-clonic seizures that are provoked by flashing or flickering light.	UMLS:C1846131	hp.json	Seizures, tonic-clonic, photosensitive|Photically induced tonic-clonic seizure|Photosensitive tonic-clonic seizures	http://purl.obolibrary.org/obo/HP_0007207		
HP:0007200	biolink:PhenotypicFeature	Episodic hypersomnia		UMLS:C4024925	hp.json		http://purl.obolibrary.org/obo/HP_0007200		
HP:0007201	biolink:PhenotypicFeature	Cerebral artery atherosclerosis	Atherosclerosis (HP:0002621) of a cerebral artery.	UMLS:C4024924	hp.json	Plaque build-up in cerebral artery	http://purl.obolibrary.org/obo/HP_0007201		
UBERON:0000400	biolink:AnatomicalEntity	jejunal epithelium	An epithelium that is part of a jejunum.	CALOHA:TS-0494|MA:0003215|FMA:17232|BTO:0001743|EMAPA:18668	hp.json	epithelium of jejunum	http://purl.obolibrary.org/obo/UBERON_0000400		human_reference_atlas
UBERON:0000401	biolink:AnatomicalEntity	mandibular ramus	The upturned perpendicular extremity of the mandible.	EMAPA:25100|BTO:0001751|MA:0002815|FMA:52828	hp.json	lower ramus|rami mandibulae|ramus mandibulae|mandible ramus|ramus mandibulae|ramus of mandible	http://purl.obolibrary.org/obo/UBERON_0000401		pheno_slim
HP:0010852	biolink:PhenotypicFeature	EEG with photoparoxysmal response	EEG abnormalities (epileptiform discharges) evoked by flashing lights or black and white striped patterns.	UMLS:C3552821	hp.json	Photoparoxysmal response on EEG	http://purl.obolibrary.org/obo/HP_0010852		
HP:0010851	biolink:PhenotypicFeature	EEG with burst suppression	The burst suppression pattern in electroencephalography refers to a characteristic periodic pattern of low voltage (<10 microvolts) suppressed background and a relatively shorter pattern of higher amplitude slow, sharp, and spiking complexes.	UMLS:C1969156	hp.json		http://purl.obolibrary.org/obo/HP_0010851		
HP:0010850	biolink:PhenotypicFeature	EEG with spike-wave complexes	Complexes of spikes (<70 ms) and sharp waves (70-200 ms), which are sharp transient waves that have a strong association with epilepsy, in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).	UMLS:C4023683	hp.json		http://purl.obolibrary.org/obo/HP_0010850		
HP:0010859	biolink:PhenotypicFeature	Frank breech presentation	A kind of breech presentation in which the hips are flexed and the knees are extended.	SNOMEDCT_US:18559007|MSH:D001946|UMLS:C0233286	hp.json		http://purl.obolibrary.org/obo/HP_0010859		
HP:0010858	biolink:PhenotypicFeature	EEG with hyperventilation-induced epileptiform discharges	Epileptiform discharges induced by hyperventilation (overbreathing) in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).	UMLS:C4023682	hp.json		http://purl.obolibrary.org/obo/HP_0010858		
HP:0010857	biolink:PhenotypicFeature	EEG with periodic abnormalities	Periodically recurring abnormalities in the EEG.	UMLS:C4021211	hp.json	EEG: periodic abnormalities	http://purl.obolibrary.org/obo/HP_0010857		
HP:0007215	biolink:PhenotypicFeature	Periodic hyperkalemic paralysis	Episodes of muscle weakness associated with elevated levels of potassium in the blood.	SNOMEDCT_US:304737009|UMLS:C0238357|MSH:D020513	hp.json	Hyperkalemic periodic paralysis	http://purl.obolibrary.org/obo/HP_0007215		
HP:0010856	biolink:PhenotypicFeature	EEG with periodic complexes	Periodically occurring generalized periodic complexes.	UMLS:C4021212	hp.json	EEG: periodic complexes|Radermecker complexes	http://purl.obolibrary.org/obo/HP_0010856		
HP:0009878	biolink:PhenotypicFeature	Cerebellar ataxia associated with quadrupedal gait	The presence of cerebellar signs and symptoms such as lack of balance associated with quadrupedal gait (locomotion on all four extremities with a 'bear-like' gait with the legs held straight).	UMLS:C4024175	hp.json		http://purl.obolibrary.org/obo/HP_0009878		
HP:0010855	biolink:PhenotypicFeature	EEG with localized low amplitude activity	An abnormal localized reduction in amplitude of the cerebral electrical activity recorded along the scalp by electroencephalography (EEG).	UMLS:C4021213	hp.json	EEG with localised low amplitude activity|EEG: localised low amplitude activity	http://purl.obolibrary.org/obo/HP_0010855		
HP:0010854	biolink:PhenotypicFeature	EEG with generalized low amplitude activity	An abnormal generalized reduction in amplitude of the cerebral electrical activity recorded along the scalp by electroencephalography (EEG).	UMLS:C4021214	hp.json	EEG with generalised low amplitude activity|EEG: generalised low amplitude activity	http://purl.obolibrary.org/obo/HP_0010854		
HP:0009879	biolink:PhenotypicFeature	Simplified gyral pattern	An abnormality of the cerebral cortex with fewer gyri but with normal cortical thickness. This pattern is usually often associated with congenital microcephaly.	UMLS:C2749675	hp.json	Cortical gyral simplification	http://purl.obolibrary.org/obo/HP_0009879		
HP:0010853	biolink:PhenotypicFeature	EEG with periodic lateralized epileptiform discharges	Periodic lateralized epileptiform discharges (PLEDs)are periodic, lateralized, and epileptiform. PLEDs show a relatively constant interval between discharges (0.5 to 3 seconds).	UMLS:C4021215	hp.json	EEG: periodic lateralized epileptiform discharges	http://purl.obolibrary.org/obo/HP_0010853		
HP:0009875	biolink:PhenotypicFeature	Triangular shaped distal phalanges of the hand		UMLS:C4024176	hp.json	Triangular shaped outermost bone of the hand	http://purl.obolibrary.org/obo/HP_0009875		
HP:0007210	biolink:PhenotypicFeature	Lower limb amyotrophy	Muscular atrophy affecting the lower limb.	UMLS:C4024921	hp.json		http://purl.obolibrary.org/obo/HP_0007210		
GO:0050668	biolink:BiologicalProcess	positive regulation of homocysteine metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine.		hp.json	upregulation of homocysteine metabolic process|positive regulation of Hcy metabolic process|stimulation of homocysteine metabolic process|up regulation of homocysteine metabolic process|positive regulation of Hcy metabolism|positive regulation of homocysteine metabolism|activation of homocysteine metabolic process|up-regulation of homocysteine metabolic process	http://purl.obolibrary.org/obo/GO_0050668		
GO:0050669	biolink:BiologicalProcess	negative regulation of homocysteine metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine.		hp.json	negative regulation of homocysteine metabolism|down regulation of homocysteine metabolic process|inhibition of homocysteine metabolic process|down-regulation of homocysteine metabolic process|negative regulation of Hcy metabolism|negative regulation of Hcy metabolic process|downregulation of homocysteine metabolic process	http://purl.obolibrary.org/obo/GO_0050669		
GO:0050666	biolink:BiologicalProcess	regulation of homocysteine metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.		hp.json	regulation of Hcy metabolic process|regulation of Hcy metabolism|regulation of homocysteine metabolism	http://purl.obolibrary.org/obo/GO_0050666		
GO:0050667	biolink:BiologicalProcess	homocysteine metabolic process	The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine.		hp.json	homocysteine metabolism|Hcy metabolism|Hcy metabolic process	http://purl.obolibrary.org/obo/GO_0050667		
GO:1902414	biolink:BiologicalProcess	protein localization to cell junction	A process in which a protein is transported to, or maintained in, a location within a cell junction.		hp.json	protein localization in cell junction|protein localisation to cell junction|protein localisation in cell junction	http://purl.obolibrary.org/obo/GO_1902414		
CL:0002308	biolink:Cell	epithelial cell of skin gland	An epithelial cell of a skin gland.	FMA:70657	hp.json	epithelial cell of gland of skin	http://purl.obolibrary.org/obo/CL_0002308		
GO:0098609	biolink:BiologicalProcess	cell-cell adhesion	The attachment of one cell to another cell via adhesion molecules.		hp.json	single organismal cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0098609		
CHEBI:142163	biolink:ChemicalSubstance	24G7 epitope	An antigenic epitope recognized by an anti-bilirubin monoclonal antibody designated 24G7. A substructure of bilirubin IXalpha, it is the region containing the oxo group at C-1, the methyl group at C-2, C-(4, 5, 6, 9), and N-21 and -22.		hp.json		http://purl.obolibrary.org/obo/CHEBI_142163		3_STAR
GO:0050673	biolink:BiologicalProcess	epithelial cell proliferation	The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.		hp.json		http://purl.obolibrary.org/obo/GO_0050673		
GO:0050679	biolink:BiologicalProcess	positive regulation of epithelial cell proliferation	Any process that activates or increases the rate or extent of epithelial cell proliferation.		hp.json	up-regulation of epithelial cell proliferation|up regulation of epithelial cell proliferation|activation of epithelial cell proliferation|stimulation of epithelial cell proliferation|upregulation of epithelial cell proliferation	http://purl.obolibrary.org/obo/GO_0050679		
GO:0050678	biolink:BiologicalProcess	regulation of epithelial cell proliferation	Any process that modulates the frequency, rate or extent of epithelial cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0050678		
CL:0002319	biolink:Cell	neural cell	A cell that is part of the nervous system.	FMA:70333|CALOHA:TS-2040	hp.json		http://purl.obolibrary.org/obo/CL_0002319		
CL:0002312	biolink:Cell	somatotroph	An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.	FMA:83095	hp.json	somatrophic cell|somatotropic cell|somatotrope	http://purl.obolibrary.org/obo/CL_0002312		
GO:0050671	biolink:BiologicalProcess	positive regulation of lymphocyte proliferation	Any process that activates or increases the rate or extent of lymphocyte proliferation.		hp.json	upregulation of lymphocyte proliferation|up regulation of lymphocyte proliferation|stimulation of lymphocyte proliferation|up-regulation of lymphocyte proliferation|activation of lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0050671		
GO:0050672	biolink:BiologicalProcess	negative regulation of lymphocyte proliferation	Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation.		hp.json	down regulation of lymphocyte proliferation|inhibition of lymphocyte proliferation|down-regulation of lymphocyte proliferation|downregulation of lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0050672		
GO:0050670	biolink:BiologicalProcess	regulation of lymphocyte proliferation	Any process that modulates the frequency, rate or extent of lymphocyte proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0050670		
GO:0023023	biolink:MolecularActivity	MHC protein complex binding	Binding to a major histocompatibility complex.		hp.json		http://purl.obolibrary.org/obo/GO_0023023		
GO:0050687	biolink:BiologicalProcess	negative regulation of defense response to virus	Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.		hp.json	negative regulation of antiviral response|down regulation of antiviral response|inhibition of antiviral response|down-regulation of antiviral response|downregulation of antiviral response	http://purl.obolibrary.org/obo/GO_0050687		
GO:0023026	biolink:MolecularActivity	MHC class II protein complex binding	Binding to a class II major histocompatibility complex.		hp.json		http://purl.obolibrary.org/obo/GO_0023026		
GO:0050688	biolink:BiologicalProcess	regulation of defense response to virus	Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.		hp.json	regulation of antiviral response	http://purl.obolibrary.org/obo/GO_0050688		
GO:0050680	biolink:BiologicalProcess	negative regulation of epithelial cell proliferation	Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.		hp.json	down-regulation of epithelial cell proliferation|down regulation of epithelial cell proliferation|downregulation of epithelial cell proliferation|inhibition of epithelial cell proliferation	http://purl.obolibrary.org/obo/GO_0050680		
GO:0060004	biolink:BiologicalProcess	reflex	An automatic response to a stimulus beginning with a nerve impulse from a receptor and ending with the action of an effector such as a gland or a muscle. Signaling never reaches a level of consciousness.	Wikipedia:Reflex	hp.json		http://purl.obolibrary.org/obo/GO_0060004		
GO:0060005	biolink:NamedThing	vestibular reflex			hp.json		http://purl.obolibrary.org/obo/GO_0060005		
GO:0023019	biolink:BiologicalProcess	signal transduction involved in regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.		hp.json	regulation of gene expression as a consequence of signal transmission	http://purl.obolibrary.org/obo/GO_0023019		
GO:0098642	biolink:CellularComponent	network-forming collagen trimer	A collagen trimer that forms networks.		hp.json		http://purl.obolibrary.org/obo/GO_0098642		
GO:0098643	biolink:CellularComponent	banded collagen fibril	A supramolecular assembly of fibrillar collagen complexes in the form of a long fiber (fibril) with transverse striations (bands).		hp.json		http://purl.obolibrary.org/obo/GO_0098643		
GO:0098641	biolink:MolecularActivity	cadherin binding involved in cell-cell adhesion	Any cadherin binding that occurs as part of the process of cell-cell adhesion.		hp.json		http://purl.obolibrary.org/obo/GO_0098641		
GO:0001696	biolink:BiologicalProcess	gastric acid secretion	The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.		hp.json	hydrochloric acid secretion	http://purl.obolibrary.org/obo/GO_0001696		
HP:0009809	biolink:PhenotypicFeature	Abnormal upper limb metaphysis morphology	An anomaly of one or more metaphyses of the arms.	UMLS:C4021388	hp.json	Abnormality of the wide portion of upper limb bone|Metaphyseal abnormality of the upper limbs|Abnormality of upper limb metaphysis	http://purl.obolibrary.org/obo/HP_0009809		
HP:0009808	biolink:PhenotypicFeature	Anomaly of the upper limb diaphyses	A structural abnormality of a diaphysis of the arm.	UMLS:C4021389	hp.json	Diaphyseal abnormality of the upper limbs|Abnormality of shaft of long bone of the upper limbs|Abnormality involving the diaphyses of the upper limbs	http://purl.obolibrary.org/obo/HP_0009808		
HP:0010805	biolink:PhenotypicFeature	Upturned corners of mouth	Oral commissures positioned superior to the midline labial fissure.	UMLS:C3553471	hp.json	Upturned oral commisures|Upturned corners of mouth|Upturned mouth	http://purl.obolibrary.org/obo/HP_0010805		hposlim_core
HP:0009805	biolink:PhenotypicFeature	Low-output congestive heart failure	A form of heart failure characterized by reduced cardiac output. This may be seen in patients with heart failure owing to ischemic heart disease, hypertension, cardiomyopathy, and other causes.	UMLS:C4024201	hp.json		http://purl.obolibrary.org/obo/HP_0009805		
HP:0010804	biolink:PhenotypicFeature	Tented upper lip vermilion	Triangular appearance of the oral aperture with the apex in the midpoint of the upper vermilion and the lower vermilion forming the base.	UMLS:C1839767|UMLS:C1853383|UMLS:C1850072	hp.json	Tented mouth|Inverted V-shaped upper lip|Tented upper lip	http://purl.obolibrary.org/obo/HP_0010804		hposlim_core
HP:0009804	biolink:PhenotypicFeature	Tooth agenesis	The absence of one or more teeth from the normal series by a failure to develop	UMLS:C4024202|UMLS:C4083050	hp.json	Reduced number of teeth|Missing some teeth|Teeth, agenesis|Failure of development of some teeth|Fewer teeth than normal|Decreased tooth count|Dental agenesis|Decreased number of teeth	http://purl.obolibrary.org/obo/HP_0009804		
HP:0010803	biolink:PhenotypicFeature	Everted upper lip vermilion	Inner aspect of the upper lip vermilion (normally apposing the teeth) visible in a frontal view, i.e., the presence of an everted upper lip.	UMLS:C4280363|UMLS:C4023698|UMLS:C3275452	hp.json	Eclabium of upper lip|Everted upper lip|Protruding upper lip|Outward turned upper lip|Everted prominent upper lip|Drooping upper lip	http://purl.obolibrary.org/obo/HP_0010803		hposlim_core
HP:0010802	biolink:PhenotypicFeature	Perioral hyperpigmentation	Increased pigmentation, either focal or generalized, of the skin surrounding the vermilion of the lips.	UMLS:C4023699	hp.json	Darkening of skin around the mouth|Increased pigmentation around the mouth	http://purl.obolibrary.org/obo/HP_0010802		
HP:0009806	biolink:PhenotypicFeature	Nephrogenic diabetes insipidus	A form of diabetes insipidus caused by failure of the kidneys to respond to vasopressin (AVP).	MSH:D018500|UMLS:C0162283|SNOMEDCT_US:111395007	hp.json		http://purl.obolibrary.org/obo/HP_0009806		
GO:0060037	biolink:BiologicalProcess	pharyngeal system development	The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.		hp.json		http://purl.obolibrary.org/obo/GO_0060037		
HP:0010801	biolink:PhenotypicFeature	Underdeveloped nasolabial fold	Reduced bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion or commissure).	UMLS:C4021227	hp.json	Nasolabial fold, hypoplastic|Nasolabial crease, underdeveloped|Flat nasolabial fold|Shallow nasolabial fold|Nasolabial crease, hypoplastic	http://purl.obolibrary.org/obo/HP_0010801		hposlim_core
GO:0060038	biolink:BiologicalProcess	cardiac muscle cell proliferation	The expansion of a cardiac muscle cell population by cell division.		hp.json	heart muscle cell proliferation|cardiac myocyte proliferation|cardiomyocyte proliferation	http://purl.obolibrary.org/obo/GO_0060038		
HP:0010800	biolink:PhenotypicFeature	Absent cupid's bow	Lack of paramedian peaks and median notch of the upper lip vermilion.	UMLS:C2053435	hp.json	Lack of cupid's bow|Absent cupid's bow|Missing cupid's bow|Agenesis of cupid's bow|Failure of development of cupid's bow|Aplasia of cupid's bow	http://purl.obolibrary.org/obo/HP_0010800		hposlim_core
HP:0009800	biolink:PhenotypicFeature	Maternal diabetes	Maternal diabetes can either be a gestational, mostly type 2 diabetes, or a type 1 diabetes. Essential is the resulting maternal hyperglycemia as a non-specific teratogen, imposing the same risk of congenital malformations to pregnant women with both type 1 and type2 diabetes.	UMLS:C4020778|UMLS:C0085207|SNOMEDCT_US:11687002|MSH:D016640	hp.json	gestational diabetes|Maternal diabetes|maternal hyperglycemia	http://purl.obolibrary.org/obo/HP_0009800		
GO:0060039	biolink:BiologicalProcess	pericardium development	The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.		hp.json		http://purl.obolibrary.org/obo/GO_0060039		
HP:0009803	biolink:PhenotypicFeature	Short phalanx of finger	Short (hypoplastic) phalanx of finger, affecting one or more phalanges.	UMLS:C0877165	hp.json	Shortened phalanges|Rudimentary phalanges|Hypoplastic phalanges of hands|Hypoplastic phalanges|Hypoplastic/small phalanges of the hand|Short finger bones|Short phalanges|Phalangeal hypoplasia	http://purl.obolibrary.org/obo/HP_0009803		
HP:0009802	biolink:PhenotypicFeature	Aplasia of the phalanges of the hand	Absence of one or more of the phalanges of the hand.	UMLS:C4280393|UMLS:C4024203	hp.json	Absent finger bone of the hand	http://purl.obolibrary.org/obo/HP_0009802		
HP:0010809	biolink:PhenotypicFeature	Broad uvula	Increased width of the uvula (subjective finding).	UMLS:C3693299	hp.json	Wide uvula	http://purl.obolibrary.org/obo/HP_0010809		hposlim_core
HP:0010808	biolink:PhenotypicFeature	Protruding tongue	Tongue extending beyond the alveolar ridges or teeth at rest.	SNOMEDCT_US:249872000|UMLS:C0241442|SNOMEDCT_US:285503005	hp.json	Prominent tongue|Protruding tongue|Lingual prolapse|Lingual prominence|Lingual protrusion|Tongue protrusion|Tongue sticking out of mouth|Prolapse of tongue	http://purl.obolibrary.org/obo/HP_0010808		hposlim_core
HP:0010807	biolink:PhenotypicFeature	Open bite	Visible space between the dental arches in occlusion.	SNOMEDCT_US:35580009|UMLS:C0266061|MSH:D024343	hp.json	Open bite|Open bite between upper and lower teeth|Absence of overlap of upper and lower teeth	http://purl.obolibrary.org/obo/HP_0010807		hposlim_core
GO:0098644	biolink:CellularComponent	complex of collagen trimers	A complex of collagen trimers such as a fibril or collagen network.		hp.json	Supramolecular collagen assembly|Supramolecular aggregate of collagen	http://purl.obolibrary.org/obo/GO_0098644		
HP:0010806	biolink:PhenotypicFeature	U-Shaped upper lip vermilion	Gentle upward curve of the upper lip vermilion such that the center is placed well superior to the commissures.	UMLS:C1856202	hp.json	Carp-like mouth|Large, carp-shaped mouth|Carp-shaped mouth|Wide, carp-shaped mouth|Fish mouth	http://purl.obolibrary.org/obo/HP_0010806		
GO:0098645	biolink:CellularComponent	collagen network	A supramolecular complex that consists of collagen triple helices associated to form a network.		hp.json		http://purl.obolibrary.org/obo/GO_0098645		
GO:0072001	biolink:BiologicalProcess	renal system development	The process whose specific outcome is the progression of the renal system over time, from its formation to the mature structure. The renal system maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels.		hp.json	urinary tract development|urinary system development	http://purl.obolibrary.org/obo/GO_0072001		gocheck_do_not_annotate
GO:0098651	biolink:CellularComponent	basement membrane collagen trimer	Any collagen timer that is part of a basement membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0098651		
HP:0009819	biolink:PhenotypicFeature	Lower limb phocomelia	Phocomelia affecting only the lower limbs.	UMLS:C0265625|SNOMEDCT_US:253963009	hp.json		http://purl.obolibrary.org/obo/HP_0009819		
GO:1902463	biolink:BiologicalProcess	protein localization to cell leading edge	A process in which a protein is transported to, or maintained in, a location within a cell leading edge.		hp.json	protein localization in cell leading edge|protein localisation to cell leading edge|protein localisation in cell leading edge	http://purl.obolibrary.org/obo/GO_1902463		
HP:0009816	biolink:PhenotypicFeature	Lower limb undergrowth	Leg shortening because of underdevelopment of one or more bones of the lower extremity.	UMLS:C0345371|SNOMEDCT_US:253959002	hp.json	Lower limb undergrowth|Underdeveloped lower limb bones|Hypoplasia of the lower limbs|Hypoplasia involving bones of the lower limbs	http://purl.obolibrary.org/obo/HP_0009816		
GO:1902473	biolink:BiologicalProcess	regulation of protein localization to synapse	Any process that modulates the frequency, rate or extent of protein localization to synapse.		hp.json	regulation of protein localisation to synapse	http://purl.obolibrary.org/obo/GO_1902473		
HP:0009815	biolink:PhenotypicFeature	Aplasia/hypoplasia of the extremities	Absence (due to failure to form) or underdevelopment of the extremities.	UMLS:C0239399	hp.json	Absent/underdeveloped extremities|Shortened limbs|Short or absent limbs|Absent/small extremities	http://purl.obolibrary.org/obo/HP_0009815		
HP:0009818	biolink:PhenotypicFeature	Amelia involving the lower limbs	Amelia of one or both legs.	UMLS:C4024197	hp.json		http://purl.obolibrary.org/obo/HP_0009818		
HP:0009817	biolink:PhenotypicFeature	Aplasia involving bones of the lower limbs		UMLS:C4024198	hp.json	Absent bones of the lower limbs	http://purl.obolibrary.org/obo/HP_0009817		
HP:0009812	biolink:PhenotypicFeature	Amelia involving the upper limbs	Amelia of one or both upper limbs.	UMLS:C4024200	hp.json		http://purl.obolibrary.org/obo/HP_0009812		
HP:0009811	biolink:PhenotypicFeature	Abnormality of the elbow	An anomaly of the joint that connects the upper and the lower arm.	UMLS:C4021386	hp.json	Abnormality of the elbows|Abnormality of the elbow	http://purl.obolibrary.org/obo/HP_0009811		hposlim_core
HP:0009814	biolink:PhenotypicFeature	Upper limb peromelia	Peromelia affecting only the upper limbs. That is, the distal parts of the arm are missing leading to stump formation.	UMLS:C4024199	hp.json		http://purl.obolibrary.org/obo/HP_0009814		
HP:0009813	biolink:PhenotypicFeature	Upper limb phocomelia	Missing or malformed long bones of the upper limbs with the distal parts (the hands) connected to the variably shortened or even absent upper extremity, leading to a flipper-like appearance, as opposed to other forms of limb malformations were either the whole limb is missing (such as amelia), or the distal part of a limb is absent (peromelia).	SNOMEDCT_US:253926000|UMLS:C0265573	hp.json		http://purl.obolibrary.org/obo/HP_0009813		
HP:0009810	biolink:PhenotypicFeature	Abnormality of upper limb joint		UMLS:C4021387	hp.json	Abnormality of upper limb joint|Abnormality of the joints of the upper limbs	http://purl.obolibrary.org/obo/HP_0009810		
GO:0098657	biolink:BiologicalProcess	import into cell	The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.		hp.json	uptake	http://purl.obolibrary.org/obo/GO_0098657		
GO:0098655	biolink:BiologicalProcess	cation transmembrane transport	The process in which a cation is transported across a membrane.		hp.json	ATP hydrolysis coupled cation transmembrane transport	http://purl.obolibrary.org/obo/GO_0098655		
GO:0098656	biolink:BiologicalProcess	anion transmembrane transport	The process in which an anion is transported across a membrane.		hp.json	ATP hydrolysis coupled anion transmembrane transport	http://purl.obolibrary.org/obo/GO_0098656		
GO:0001676	biolink:BiologicalProcess	long-chain fatty acid metabolic process	The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.		hp.json	long-chain fatty acid metabolism	http://purl.obolibrary.org/obo/GO_0001676		
GO:0001677	biolink:BiologicalProcess	formation of translation initiation ternary complex	Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).		hp.json	translation initiation ternary complex assembly	http://purl.obolibrary.org/obo/GO_0001677		
GO:0001674	biolink:CellularComponent	female germ cell nucleus	The nucleus of the female germ cell, a reproductive cell in females.		hp.json	female germ-cell nucleus	http://purl.obolibrary.org/obo/GO_0001674		
GO:0060050	biolink:BiologicalProcess	positive regulation of protein glycosylation	Any process that activates or increases the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.		hp.json	positive regulation of protein amino acid glycosylation	http://purl.obolibrary.org/obo/GO_0060050		
GO:0060051	biolink:BiologicalProcess	negative regulation of protein glycosylation	Any process that stops, prevents, or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.		hp.json	negative regulation of protein amino acid glycosylation	http://purl.obolibrary.org/obo/GO_0060051		
GO:1902474	biolink:BiologicalProcess	positive regulation of protein localization to synapse	Any process that activates or increases the frequency, rate or extent of protein localization to synapse.		hp.json	upregulation of protein localisation to synapse|up-regulation of protein localization to synapse|up regulation of protein localization to synapse|activation of protein localization to synapse|up-regulation of protein localisation to synapse|upregulation of protein localization to synapse|up regulation of protein localisation to synapse|activation of protein localisation to synapse|positive regulation of protein localisation to synapse	http://purl.obolibrary.org/obo/GO_1902474		
GO:1902475	biolink:BiologicalProcess	L-alpha-amino acid transmembrane transport	The directed movement of L-alpha-amino acid across a membrane.		hp.json		http://purl.obolibrary.org/obo/GO_1902475		
GO:0098631	biolink:MolecularActivity	cell adhesion mediator activity	The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface, to mediate adhesion of the cell to the external substrate or to another cell.		hp.json	protein binding involved in cell adhesion|cell adhesion molecule	http://purl.obolibrary.org/obo/GO_0098631		goslim_generic
OBO:nbo#has_participant	biolink:NamedThing	has_participant			hp.json		http://purl.obolibrary.org/obo/nbo#has_participant		
GO:0098632	biolink:MolecularActivity	cell-cell adhesion mediator activity	The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell.		hp.json	protein binding involved in cell-cell adhesion|cell-cell adhesion molecule	http://purl.obolibrary.org/obo/GO_0098632		
GO:0060041	biolink:BiologicalProcess	retina development in camera-type eye	The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.		hp.json	retinal development|retina development in camera-style eye	http://purl.obolibrary.org/obo/GO_0060041		
GO:0060042	biolink:BiologicalProcess	retina morphogenesis in camera-type eye	The process in which the anatomical structure of the retina is generated and organized.		hp.json	retina morphogenesis in camera-style eye|retinogenesis	http://purl.obolibrary.org/obo/GO_0060042		
GO:0060043	biolink:BiologicalProcess	regulation of cardiac muscle cell proliferation	Any process that modulates the frequency, rate or extent of cardiac muscle cell proliferation.		hp.json	regulation of heart muscle cell proliferation|regulation of cardiomyocyte proliferation	http://purl.obolibrary.org/obo/GO_0060043		
GO:0060044	biolink:BiologicalProcess	negative regulation of cardiac muscle cell proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation.		hp.json	negative regulation of heart muscle cell proliferation	http://purl.obolibrary.org/obo/GO_0060044		
GO:1902494	biolink:CellularComponent	catalytic complex	A protein complex which is capable of catalytic activity.		hp.json	enzyme complex	http://purl.obolibrary.org/obo/GO_1902494		goslim_metagenomics
GO:0060045	biolink:BiologicalProcess	positive regulation of cardiac muscle cell proliferation	Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.		hp.json	positive regulation of heart muscle cell proliferation	http://purl.obolibrary.org/obo/GO_0060045		
GO:0060047	biolink:BiologicalProcess	heart contraction	The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.		hp.json	heart beating|cardiac contraction|hemolymph circulation	http://purl.obolibrary.org/obo/GO_0060047		
GO:1902492	biolink:NamedThing	positive regulation of sperm capacitation			hp.json		http://purl.obolibrary.org/obo/GO_1902492		
GO:0060048	biolink:BiologicalProcess	cardiac muscle contraction	Muscle contraction of cardiac muscle tissue.		hp.json	heart muscle contraction	http://purl.obolibrary.org/obo/GO_0060048		
GO:0060049	biolink:BiologicalProcess	regulation of protein glycosylation	Any process that modulates the frequency, rate or extent of protein glycosylation. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.		hp.json	regulation of protein amino acid glycosylation	http://purl.obolibrary.org/obo/GO_0060049		
GO:1902490	biolink:NamedThing	regulation of sperm capacitation			hp.json		http://purl.obolibrary.org/obo/GO_1902490		
GO:1902491	biolink:NamedThing	negative regulation of sperm capacitation			hp.json		http://purl.obolibrary.org/obo/GO_1902491		
GO:0098635	biolink:CellularComponent	protein complex involved in cell-cell adhesion	Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion.		hp.json		http://purl.obolibrary.org/obo/GO_0098635		
GO:0098636	biolink:CellularComponent	protein complex involved in cell adhesion	Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell.		hp.json	cell adhesion complex	http://purl.obolibrary.org/obo/GO_0098636		
GO:0098633	biolink:MolecularActivity	collagen fibril binding	Binding to a collagen fibril.		hp.json		http://purl.obolibrary.org/obo/GO_0098633		
HP:0032192	biolink:PhenotypicFeature	Hydatidiform mole	Hydatidiform mole (HM) is an aberrant human pregnancy with absence of, or abnormal embryonic development, hydropic degeneration of chorionic villi, and excessive proliferation of the trophoblast.		hp.json		http://purl.obolibrary.org/obo/HP_0032192		
HP:0032193	biolink:PhenotypicFeature	Decreased low-density lipoprotein particle size	An abnormal decrease in the average size of low-density lipoprotein particle size in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032193		
HP:0032195	biolink:PhenotypicFeature	Abnormal S wave	Any anomaly of the S wave, which is the third component of the QRS wave complex. The S wave signifies the final depolarization of the ventricles at the base of the heart.		hp.json		http://purl.obolibrary.org/obo/HP_0032195		
HP:0032190	biolink:PhenotypicFeature	Abnormal meniscus morphology	Abnormal structure of the meniscus of the knee, two crescent shape fibrocartilaginous pads that disperse the weight of the body and reduce friction of the knee joint during movement.		hp.json		http://purl.obolibrary.org/obo/HP_0032190		
HP:0032191	biolink:PhenotypicFeature	Torn meniscus	A tear in the cartilaginous pad (meniscus) of the knee.		hp.json		http://purl.obolibrary.org/obo/HP_0032191		
HP:0032196	biolink:PhenotypicFeature	Prominent S wave in lead I	Increased amplitude (0.1 mV or more) and/or duration (40 ms or more) of the S wave as measured in lead I of the electrocardiogram.		hp.json		http://purl.obolibrary.org/obo/HP_0032196		
HP:0032197	biolink:PhenotypicFeature	Deep S wave in lead V5	Abnormal depth of the S wave in lead V5 of the electrocardiogram.		hp.json		http://purl.obolibrary.org/obo/HP_0032197		
HP:0032198	biolink:PhenotypicFeature	Decreased prothrombin time	Abnormally short time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT.		hp.json	Decreased international normalized ratio|Decreased INR|Decreased international normalised ratio|Decreased PT	http://purl.obolibrary.org/obo/HP_0032198		
HP:0032199	biolink:PhenotypicFeature	Abnormal prothrombin time	Any deviation from the normal amount of time to coagulation in the prothrombin time test, which is a measure of the extrinsic pathway of coagulation. The results of the prothrombin time test are often expressed in terms of the International normalized ratio (INR), which is calculated as a ratio of the patient's prothrombin time (PT) to a control PT standardized for the potency of the thromboplastin reagent developed by the World Health Organization (WHO) using the formula: INR is equal to Patient PT divided by Control PT.		hp.json	Abnormal PT	http://purl.obolibrary.org/obo/HP_0032199		
HP:0020192	biolink:PhenotypicFeature	Pachygyria with 5-10 mm cortical thickness	Pachygyria with a mildly thickend cerebral cortex measuring 5-10 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age.		hp.json		http://purl.obolibrary.org/obo/HP_0020192		
HP:0020191	biolink:PhenotypicFeature	Anterior predominant thick cortex pachygyria	Pachygyria with cortical thickness greater than 10 mm and an anterior predominant severity gradient. The severety gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Anterior predominant gradient indicates pachygyria more severe over the frontal and temporal lobes.		hp.json	Pachygyria with cortical thickness > 10 mm anterior predominant	http://purl.obolibrary.org/obo/HP_0020191		
HP:0020194	biolink:PhenotypicFeature	IgA heavy chain paraproteinemia	An abnormal IgA heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.		hp.json	Alpha heavy chain disease	http://purl.obolibrary.org/obo/HP_0020194		
HP:0020193	biolink:PhenotypicFeature	Prolonged reptilase time	An abnormally increased duration of the reptilase time. Reptilase time is a functional plasma clotting assay, which is based on the enzymatic activity of batroxobin. By specifically cleaving fibrinogen A from fibrinogen, batroxobin leads to the formation of a stable fibrin clot. The time, starting from the addition of batroxobin to the plasma sample, until clot formation is the reptilase time and is given in seconds.		hp.json		http://purl.obolibrary.org/obo/HP_0020193		
HP:0020190	biolink:PhenotypicFeature	Perisylvian predominant thick cortex pachygyria	Pachygyria with cortical thickness greater than 10 mm and a perisylvian predominant severity gradient. The severity gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Perisylvian predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria.		hp.json	Pachygyria with cortical thickness > 10 mm perisylvian predominant	http://purl.obolibrary.org/obo/HP_0020190		
CHEBI:25629	biolink:ChemicalSubstance	octadecanoate	A fatty acid anion 18:0 that is the conjugate base of octadecanoic acid (stearic acid). Stearates have a variety of uses in the pharmaceutical industry.	Gmelin:344065|PMID:19184617|Beilstein:3590530|Reaxys:3590530|MetaCyc:STEARIC_ACID|KEGG:C01530|PMID:7452460|CAS:646-29-7|PMID:3180776|PMID:16401590	hp.json	stearic acid, ion(1-)|CH3-[CH2]16-COO(-)|octadecanoic acid, ion(1-)|octadecanoate|Stearate|octadecanoate|stearate	http://purl.obolibrary.org/obo/CHEBI_25629		3_STAR
HP:0020199	biolink:PhenotypicFeature	Decreased circulating 18-hydroxycortisone level	A subnormal concentration of 18-Hydroxycorticosterone level in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0020199		
HP:0020196	biolink:PhenotypicFeature	IgM heavy chain paraproteinemia	An abnormal IgM heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.		hp.json		http://purl.obolibrary.org/obo/HP_0020196		
HP:0020195	biolink:PhenotypicFeature	IgG heavy chain paraproteinemia	An abnormal IgG heavy chain in the circulation and typically produced by a clonal population of B-cell derived plasma cells.		hp.json	Gamma heavy-chain disease	http://purl.obolibrary.org/obo/HP_0020195		
HP:0020198	biolink:PhenotypicFeature	Abnormal circulating 18-hydroxycorticosterone level	Any deviation from the normal concentration of 18-Hydroxycorticosterone level in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0020198		
HP:0020197	biolink:PhenotypicFeature	Increased circulating arachidonic acid concentration	An increased circulation of arachidonic acid in the blood circulation.		hp.json	Increased circulating arachidonate level|Increased circulating arachidonic acid level	http://purl.obolibrary.org/obo/HP_0020197		
CL:0002364	biolink:Cell	cortical thymic epithelial cell	An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells.	BTO:0004562	hp.json	cTEC	http://purl.obolibrary.org/obo/CL_0002364		
HP:0020181	biolink:PhenotypicFeature	Reduced haptoglobin level	An abnormally low concentration of haptoglobin in the blood circulation. Decreased haptoglobin in conjunction with increased reticulocyte count and anemia may indicate hemolysis. Decreased haptoglobin levels can also occur in the absence of hemolysis, due to cirrhosis of the liver, disseminated ovarian carcinomatosis, pulmonary sarcoidosis, and elevated estrogen state.		hp.json		http://purl.obolibrary.org/obo/HP_0020181		
CL:0002363	biolink:Cell	keratocyte	A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic cell located between the lamellae with a large flattened nucleus and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratin sulfate.		hp.json	corneal fibroblast|corneal keratocyte	http://purl.obolibrary.org/obo/CL_0002363		
HP:0020180	biolink:PhenotypicFeature	Elevated haptoglobin level	An abnormally high concentration of haptoglobin in the blood circulation. Haptoglobin is an acute-phase reactant whose levels can become elevated in the presence of infection and inflammation.		hp.json		http://purl.obolibrary.org/obo/HP_0020180		
HP:0020183	biolink:PhenotypicFeature	Increased circulating A-type natriuretic peptide level	A measurable elevation in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure.		hp.json		http://purl.obolibrary.org/obo/HP_0020183		
HP:0020182	biolink:PhenotypicFeature	Abnormal A-type atrial natriuretic peptide level	A measurable change in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure.		hp.json		http://purl.obolibrary.org/obo/HP_0020182		
CL:0002368	biolink:Cell	respiratory epithelial cell	An endo-epithelial cell of the respiratory tract.	BTO:0004533	hp.json	airway epithelial cell	http://purl.obolibrary.org/obo/CL_0002368		
CL:0002367	biolink:Cell	trabecular meshwork cell	A cell that lines the trabecular meshwork, which is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea). This cell may play a role in regulating intraocular pressure.		hp.json	trabeculocyte	http://purl.obolibrary.org/obo/CL_0002367		
CHEBI:13643	biolink:ChemicalSubstance	glycol	A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent.		hp.json	glycols|Glykol	http://purl.obolibrary.org/obo/CHEBI_13643		3_STAR
HP:0020189	biolink:PhenotypicFeature	Posterior predominant thick cortex pachygyria	Pachygyria with cortical thickness above 10 mm with and a posterior predominant severety gradient. The severety gradient is determined based on the gyral width, with gyri typically wider than 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria.		hp.json	Occipital predomimant classic pachygyria|Pachygyria with cortical thickness over 10 mm posterior predominant	http://purl.obolibrary.org/obo/HP_0020189		
PR:000002976	biolink:Protein	Ly-6-like protein	A protein that is the translation product of any of the LY6 genes (LY6A-LY6I).	PIRSF:PIRSF002021	hp.json		http://purl.obolibrary.org/obo/PR_000002976		
GO:0035082	biolink:BiologicalProcess	axoneme assembly	The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.		hp.json	ciliary axoneme assembly|cilium axoneme biogenesis|flagellar axoneme assembly|cilium axoneme assembly|axoneme biogenesis|flagellum axoneme assembly	http://purl.obolibrary.org/obo/GO_0035082		
HP:0020188	biolink:PhenotypicFeature	Anterior predominant pachygyria with 5-10 mm cortical thickness	Pachygyria with cortical thickness between 5 and 10 mm with and a posterior predominant severety gradient. The severety gradient is determined based on the gyral width, with gyri typically over 5mm over the more severely affected regions. Posterior predominant gradient indicates pachygyria more severe other the occipital lobes but also includes a rare perisylvian-predominant pachygyria and a temporal predominant pachygyria.		hp.json		http://purl.obolibrary.org/obo/HP_0020188		
PR:000002978	biolink:Protein	lymphocyte antigen 6G	An Ly-6-like protein that is a translation product of the mouse Ly6g gene or a 1:1 ortholog thereof.		hp.json	Ly-6G.1|Ly-6G|Ly6g	http://purl.obolibrary.org/obo/PR_000002978		
PR:000002977	biolink:Protein	killer cell lectin-like receptor subfamily B member 1C	A KLRB1-like protein that is a translation product of the mouse Klrb1c gene or a 1:1 ortholog thereof.		hp.json	natural killer cell surface protein P1-40|CD161c|NK1.1|CD161 antigen-like family member C|Klrb1c|NKR-P1.9|Nkrp1c|ly-55c|NKR-P1 40|lymphocyte antigen 55c|Ly55c|NKR-P1C	http://purl.obolibrary.org/obo/PR_000002977		
HP:0020185	biolink:PhenotypicFeature	Superior cerebellar dysplasia	Abnormal morphological development of the superior part of the cerebellum.		hp.json		http://purl.obolibrary.org/obo/HP_0020185		
UBERON:8000009	biolink:AnatomicalEntity	Purkinje fiber network	A collection of Purkinje fibers that receives signals from the right and left bundle branches and innervates the ventricular cardiac muscle. The Purkinje fiber network creates synchronized contractions of the heart ventricles.		hp.json	Purkinje fibre network	http://purl.obolibrary.org/obo/UBERON_8000009		
PR:000002979	biolink:Protein	lymphocyte antigen 6A-2/6E-1	An Ly-6-like protein that is a translation product of the mouse Ly6a gene or a 1:1 ortholog thereof.		hp.json	Ly6a|stem cell antigen 1|T-cell-activating protein|Ly-6A.2/Ly-6E.1|SCA-1|Ly6|TAP	http://purl.obolibrary.org/obo/PR_000002979		
HP:0020184	biolink:PhenotypicFeature	Decreased circulating A-type natriuretic peptide level	A measurable reduction in circulating levels of Atrial natriuretic peptide hormone, a protein which plays an important role in the regulation of body fluid volume and blood pressure.		hp.json		http://purl.obolibrary.org/obo/HP_0020184		
HP:0020187	biolink:PhenotypicFeature	Thick pachygyria	Pachygyria with a very thick cerebral cortex measuring 10-20 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age.		hp.json	Pachygyria with cortical thickness > 10 mm|Pachygyria with cortical thickness above 10 mm	http://purl.obolibrary.org/obo/HP_0020187		
UBERON:8000006	biolink:AnatomicalEntity	left side of back	Left part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.		hp.json		http://purl.obolibrary.org/obo/UBERON_8000006		
UBERON:8000007	biolink:AnatomicalEntity	right side of back	Right part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane.		hp.json		http://purl.obolibrary.org/obo/UBERON_8000007		
HP:0020186	biolink:PhenotypicFeature	Multilobulated spleen	The fetal spleen is lobulated, and these lobules normally disappear before the birth. Lobulation of the spleen may persist into adult life and be typically seen along the medial part of the spleen. A persisting lobule results in a variation in shape of the spleen.		hp.json	Multi-lobulated spleen	http://purl.obolibrary.org/obo/HP_0020186		
GO:0106064	biolink:BiologicalProcess	regulation of cobalamin metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.		hp.json		http://purl.obolibrary.org/obo/GO_0106064		
UBERON:0012490	biolink:AnatomicalEntity	muscle layer of anal canal	A muscular coat that is part of a anal canal.	FMA:15708|SCTID:362171000	hp.json	muscular coat of anal canal|muscularis externa of anal canal|muscularis propria of anal canal|anal muscularis propria|anal canal muscularis propria|muscular layer of anal canal	http://purl.obolibrary.org/obo/UBERON_0012490		
UBERON:0012499	biolink:AnatomicalEntity	serosa of uterine tube	A serous membrane that is part of a fallopian tube.	SCTID:259593000|FMA:18316	hp.json	serosa of fallopian tube|serosa of oviduct|tunica serosa (tuba uterina)|uterine tube serosa|uterine tubal serosa|serous coat of uterine tube|tunica serosa tubae uterinae	http://purl.obolibrary.org/obo/UBERON_0012499		human_reference_atlas
HP:0020170	biolink:PhenotypicFeature	Increased blood drug concentration	High plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime.		hp.json	Increased serum drug concentration|Increased plasma drug concentration|Elevated blood drug concentration|Elevated serum drug concentrations|Elevated plasma drug concentration	http://purl.obolibrary.org/obo/HP_0020170		
CL:0002375	biolink:Cell	Schwann cell precursor	A giioblast cell that develops from a migratory neural crest cell. The SCP is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has no basal lamina. In rodents SCPs are the only cells in the Schwann cell linage that expresses Cdh19.		hp.json	Schwann cell precursor cell	http://purl.obolibrary.org/obo/CL_0002375		
CL:0002377	biolink:Cell	immature Schwann cell	A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons.	ZFA:0001725	hp.json	Schwann cell	http://purl.obolibrary.org/obo/CL_0002377		
PR:000002981	biolink:Protein	lymphocyte antigen 76 (mouse)	A protein that is a translation product of the Ly76 gene in mouse.		hp.json	ter-119|mLy76|ter119	http://purl.obolibrary.org/obo/PR_000002981		
HP:0020172	biolink:PhenotypicFeature	Adverse drug response	An unpleasant or harmful reaction resulting from treatment with a drug.		hp.json	Drug-induced response|Adverse drug reaction|Drug-induced reaction|Toxic drug response	http://purl.obolibrary.org/obo/HP_0020172		
HP:0020171	biolink:PhenotypicFeature	Decreased blood drug concentration	Low plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime.		hp.json	Reduced blood drug concentration|Decreased plasma drug concentration|Decreased serum drug concentration|Reduced serum drug concentrations|Reduced plasma drug concentration	http://purl.obolibrary.org/obo/HP_0020171		
HP:0020178	biolink:PhenotypicFeature	Abnormal dendritic cell count	A deviation from the normal count of dendritic cells in the peripheral blood circulation. Dendritic cells are of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).		hp.json		http://purl.obolibrary.org/obo/HP_0020178		
HP:0020177	biolink:PhenotypicFeature	Abnormal proportion of CD8-positive, alpha-beta TEMRA T cells	An abnormal proportion of CD8-positive, alpha-beta effector memory RA TEMRA T cells compared to the total number of T cells in the blood. These cells have the phenotype CD45RA-positive, CD45RO-negative, and CCR7-negative.		hp.json	Abnormal proportion of effector memory CD8-positive, alpha-beta T cells, terminally differentiated	http://purl.obolibrary.org/obo/HP_0020177		
HP:0020179	biolink:PhenotypicFeature	Abnormal haptoglobin level	A deviation from the normal concentration of haptoglobin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0020179		
CL:0002371	biolink:Cell	somatic cell	A cell of an organism that does not pass on its genetic material to the organism's offspring (i.e. a non-germ line cell).	WBbt:0008378|FMA:72300|BTO:0001268	hp.json		http://purl.obolibrary.org/obo/CL_0002371		_upper_level
HP:0020174	biolink:PhenotypicFeature	Refractory drug response	Absent or significantly reduced efficacy of drug intervention characterized by lack of measurable benefit or deterioration of disease course.		hp.json	Drug resistance	http://purl.obolibrary.org/obo/HP_0020174		
HP:0020173	biolink:PhenotypicFeature	Reduced drug efficacy	Decreased response to a drug intervention in comparison to the expected response.		hp.json	Decreased drug efficacy	http://purl.obolibrary.org/obo/HP_0020173		
HP:0020176	biolink:PhenotypicFeature	Cholesterol crystalluria			hp.json		http://purl.obolibrary.org/obo/HP_0020176		
CL:0002372	biolink:Cell	myotube	A transversely striated, synctial muscle cell, formed by the fusion of myoblasts.		hp.json	myotubule|single cell sarcomere	http://purl.obolibrary.org/obo/CL_0002372		
HP:0020175	biolink:PhenotypicFeature	Reduced cholinesterase level	A decreased amount of cholinesterase in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0020175		
HP:0032150	biolink:PhenotypicFeature	Paroxysmal rectal pain	Excruciating burning pain in the rectal area that may be triggered by defecation.		hp.json		http://purl.obolibrary.org/obo/HP_0032150		
HP:0032151	biolink:PhenotypicFeature	Episodic eosinophilia	Recurrent episodes of marked eosinophilia that resolve spontaneously.		hp.json		http://purl.obolibrary.org/obo/HP_0032151		
HP:0032156	biolink:PhenotypicFeature	Skin detachment	Loss of sections of skin either spontaneously or after gentle handling.		hp.json	Skin sloughing|Epidermal detachment|Detached skin	http://purl.obolibrary.org/obo/HP_0032156		
HP:0032157	biolink:PhenotypicFeature	Recurrent genital herpes	Recurrent episodes of genital herpes, typically characterized by stages of erythema, papules, short-lived vesicles, painful ulcers, and crusts on the skin of the genitals and surrounding area, and that typically resolve over a period of 2 to 3 weeks.		hp.json		http://purl.obolibrary.org/obo/HP_0032157		
HP:0032158	biolink:PhenotypicFeature	Unusual infection by anatomical site	An unusual infection classified by the affected body part.		hp.json		http://purl.obolibrary.org/obo/HP_0032158		
HP:0032159	biolink:PhenotypicFeature	Fungal meningitis	An infection of the meninges caused by a fungus. Generally, only individuals with deficiencies of the immune system contract fungal meningitis.		hp.json		http://purl.obolibrary.org/obo/HP_0032159		
HP:0032152	biolink:PhenotypicFeature	Keratosis pilaris	An anomaly of the hair follicles of the skin that typically presents as small, rough, brown folliculocentric papules distributed over characteristic areas of the skin, particularly the outer-upper arms and thighs.		hp.json	Follicular keratosis|Carpet tack sign|Chicken skin|Follicular plugging|Hyperkeratosis pilaris|Follicular keratotic plug|Lichen pilaris	http://purl.obolibrary.org/obo/HP_0032152		
HP:0032153	biolink:PhenotypicFeature	Joint subluxation	A partial dislocation of a joint.		hp.json		http://purl.obolibrary.org/obo/HP_0032153		
HP:0032154	biolink:PhenotypicFeature	Aphthous ulcer	Oral aphthous ulcers typically present as painful, sharply circumscribed fibrin-covered mucosal defects with a hyperemic border.		hp.json	Canker sore	http://purl.obolibrary.org/obo/HP_0032154		
HP:0032155	biolink:PhenotypicFeature	Abdominal cramps	A type of abdominal pain characterized by a feeling of contractions and typically fluctuating in intensity.		hp.json		http://purl.obolibrary.org/obo/HP_0032155		
CL:1000376	biolink:Cell	Purkinje myocyte of interventricular septum	A Purkinje myocyte that is part of the interventricular septum.	FMA:263182	hp.json		http://purl.obolibrary.org/obo/CL_1000376		
HP:0032160	biolink:PhenotypicFeature	Cryptococcal meningitis	A type of fungal meningitis caused by an encapsulated yeast that belongs to the genus Cryptococcus. Cryptococcus neoformans and Cryptococcus gattii are responsible for the majority of cases of human cryptococcosis.		hp.json		http://purl.obolibrary.org/obo/HP_0032160		
HP:0032161	biolink:PhenotypicFeature	Coccidioidal meningitis	A type of fungal meningitis caused by dissemination of coccidioides to basilar meninges.		hp.json		http://purl.obolibrary.org/obo/HP_0032161		
HP:0032162	biolink:PhenotypicFeature	Unusual skin infection	A type of infection of the skin that can be regarded as a sign of a pathological susceptibility to infection.		hp.json		http://purl.obolibrary.org/obo/HP_0032162		
HP:0032167	biolink:PhenotypicFeature	Clostridium difficile enteritis	An infection of the small intestine (enteritis) by clostridium difficile.		hp.json	C. difficile enteritis	http://purl.obolibrary.org/obo/HP_0032167		
HP:0032168	biolink:PhenotypicFeature	Clostridium difficile colitis	An infection of the colon (colitis) by clostridium difficile.		hp.json		http://purl.obolibrary.org/obo/HP_0032168		
HP:0032169	biolink:PhenotypicFeature	Severe infection	A type of infection that is regarded as a sign of a pathological susceptibility to infection because of unusual severity or intensity of the infection.		hp.json	Unusual course of infection	http://purl.obolibrary.org/obo/HP_0032169		
HP:0032163	biolink:PhenotypicFeature	Molluscum contagiosum	Molluscum contagiosum is a cutaneous viral infection that is commonly observed in both healthy and immunocompromised children. The infection is caused by a member of the Poxviridae family, the molluscum contagiosum virus. Molluscum contagiosum presents as single or multiple small white or flesh-colored papules that typically have a central umbilication. The central umbilication may be difficult to observe in young children and, instead, may bear an appearance similar to an acneiform eruption. The lesions vary in size (from 1 mm to 1 cm in diameter) and are painless, although a subset of patients report pruritus in the area of infection. On average, 11-20 papules appear on the body during the course of infection and generally remains a self-limiting disease. However, in immunosuppressed patients, molluscum contagiosum can be a severe infection with hundreds of lesions developing on the body. Extensive eruption is indicative of an advanced immunodeficiency state.		hp.json		http://purl.obolibrary.org/obo/HP_0032163		
HP:0032164	biolink:PhenotypicFeature	Increased blood folate concentration	An elevated circulating concentration of folic acid, which is also known as vitamin B9.		hp.json		http://purl.obolibrary.org/obo/HP_0032164		
HP:0032165	biolink:PhenotypicFeature	Placental mesenchymal dysplasia	Placental mesenchymal dysplasia is a rare anomaly characterized by placentomegaly, dilatation of chorionic vessels and hydropic stem villi with cistern-like formation. It is often clinically mistaken for a partial hydatidiform mole but there is no trophoblastic proliferation. P57 immunohistochemical expression is discordant, showing a normal positive expression in the cytotrophoblastic cells, and loss of expression in the stromal cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032165		
HP:0032166	biolink:PhenotypicFeature	Unusual gastrointestinal infection			hp.json	Unusual GI infection	http://purl.obolibrary.org/obo/HP_0032166		
CL:0002352	biolink:Cell	gestational hematopoietic stem cell	A hematopoietic stem cell that exists during embryogenesis.		hp.json		http://purl.obolibrary.org/obo/CL_0002352		
CL:1000362	biolink:Cell	transitional myocyte of interventricular septum	A transitional myocyte that is part of the interventricular septum.	FMA:263154	hp.json		http://purl.obolibrary.org/obo/CL_1000362		
CL:0002359	biolink:Cell	placental hematopoietic stem cell	A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells.		hp.json		http://purl.obolibrary.org/obo/CL_0002359		
CL:1000361	biolink:Cell	transitional myocyte of interatrial septum	A transitional myocyte that is part of the interatrial septum.	FMA:263152	hp.json		http://purl.obolibrary.org/obo/CL_1000361		
GO:0035050	biolink:BiologicalProcess	embryonic heart tube development	The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.		hp.json		http://purl.obolibrary.org/obo/GO_0035050		
GO:0035051	biolink:BiologicalProcess	cardiocyte differentiation	The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.		hp.json	cardiac cell differentiation|heart cell differentiation	http://purl.obolibrary.org/obo/GO_0035051		
CL:0002351	biolink:Cell	progenitor cell of endocrine pancreas	A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1.		hp.json	pancreatic endocrine progenitor|pancreatic islet progenitor cell	http://purl.obolibrary.org/obo/CL_0002351		
CL:0002350	biolink:Cell	endocardial cell	An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.	FMA:75621	hp.json	endothelial cell of endocardium|endocardial endothelial cell	http://purl.obolibrary.org/obo/CL_0002350		
HP:0032170	biolink:PhenotypicFeature	Severe varicella zoster infection	An unusually severe form of varicella zoster virus (VZV) infection. In the majority of the cases, especially in children, varicella is a very mild infection characterised by skin lesions, low grade fever and malaise. Severe infection is characterized by manifestions including VZV pneumonia, hepatitis, meningitis, and disseminated varicella.		hp.json		http://purl.obolibrary.org/obo/HP_0032170		
HP:0032171	biolink:PhenotypicFeature	Bladder pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the urinary bladder. Bladder pain may be more pronounced with a full bladder and relieved upon urination, but this is not always the case.		hp.json		http://purl.obolibrary.org/obo/HP_0032171		
HP:0032172	biolink:PhenotypicFeature	Air crescent sign	A crescent of air surrounding a soft-tissue mass in a pulmonary cavity and can be seen in both plain X-ray and CT scan.		hp.json		http://purl.obolibrary.org/obo/HP_0032172		
HP:0032173	biolink:PhenotypicFeature	Continuous diaphragm sign	This sign is seen in pneumomediastinum in which air accumulates between the lower border of the heart and the superior part of the diaphragm, which results in complete visualization of the diaphragm in chest X-ray, hence named continuous diaphragm sign.		hp.json		http://purl.obolibrary.org/obo/HP_0032173		
GO:0106016	biolink:BiologicalProcess	positive regulation of inflammatory response to wounding	Any process that activates or increases the frequency, rate or extent of the inflammatory response to wounding.		hp.json		http://purl.obolibrary.org/obo/GO_0106016		
GO:0106015	biolink:BiologicalProcess	negative regulation of inflammatory response to wounding	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response to wounding.		hp.json		http://purl.obolibrary.org/obo/GO_0106015		
GO:0106014	biolink:BiologicalProcess	regulation of inflammatory response to wounding	Any process that modulates the frequency, rate or extent of the inflammatory response to wounding.		hp.json		http://purl.obolibrary.org/obo/GO_0106014		
HP:0032178	biolink:PhenotypicFeature	Flaky paint dermatosis	A dermatosis characterized by generalized shiny, enamel-like, hyperpigmented scales in an irregular pattern. The scales may peel or desquamate, rather like old, sun-baked blistered paint, often with areas of underlying hypopigmentation. This has led to the terms peeling paint or flaky paint dermatosis (See the Figure in PMID:24285001).		hp.json	Flaky paint skin appearance	http://purl.obolibrary.org/obo/HP_0032178		
CL:0002328	biolink:Cell	bronchial epithelial cell	An epithelial cell of the bronchus.	BTO:0002922	hp.json		http://purl.obolibrary.org/obo/CL_0002328		
HP:0032179	biolink:PhenotypicFeature	Abnormal circulating globulin level	An abnormal concentration of globulins in the blood. Albumin makes up more than half of the total protein present in serum. The remaining blood proteins except albumin and fibrinogen (which is not in serum) are referred to as globulins. The globulin fraction includes hundreds of serum proteins including carrier proteins, enzymes, complement, and immunoglobulins. Most of these are synthesized in the liver, although the immunoglobulins are synthesized by plasma cells. Globulins are divided into four groups by electrophoresis. The four fractions are alpha1, alpha2, beta and gamma, depending on their migratory pattern between the anode and the cathode.		hp.json		http://purl.obolibrary.org/obo/HP_0032179		
GO:0023061	biolink:BiologicalProcess	signal release	The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.		hp.json	signal secretion	http://purl.obolibrary.org/obo/GO_0023061		
HP:0032174	biolink:PhenotypicFeature	Tree-in-bud pattern	The tree-in-bud pattern represents centrilobular branching structures that resemble a budding tree. The pattern reflects a spectrum of endo- and peribronchiolar disorders, including mucoid impaction, inflammation, and/or fibrosis (See Figure 70 of PMID:18195376).		hp.json		http://purl.obolibrary.org/obo/HP_0032174		
HP:0032175	biolink:PhenotypicFeature	Signet ring sign	This finding is composed of a ring-shaped opacity representing a dilated bronchus in cross section and a smaller adjacent opacity representing its pulmonary artery, with the combination resembling a signet (or pearl) ring. It is the basic sign of bronchiectasis in pulmonary computed tomography imaging.		hp.json		http://purl.obolibrary.org/obo/HP_0032175		
HP:0032176	biolink:PhenotypicFeature	Apical pulmonary opacity	An apical cap is a caplike lesion at the lung apex, usually caused by intrapulmonary and pleural fibrosis pulling down extrapleural fat or possibly by chronic ischemia resulting in hyaline plaque formation on the visceral pleura. The prevalence increases with age. It can also be seen in hematoma resulting from aortic rupture or in other fluid collection associated with infection or tumor, either outside the parietal pleura or loculated within the pleural space.		hp.json	Apical pleural thickening|Apical cap	http://purl.obolibrary.org/obo/HP_0032176		
HP:0032177	biolink:PhenotypicFeature	Parenchymal consolidation	Consolidation refers to an exudate or other product of disease that replaces alveolar air, rendering the lung solid (as in infective pneumonia).		hp.json		http://purl.obolibrary.org/obo/HP_0032177		
CL:0002320	biolink:Cell	connective tissue cell	A cell of the supporting or framework tissue of the body, arising chiefly from the embryonic mesoderm and including adipose tissue, cartilage, and bone.	FMA:63875|CALOHA:TS-2096	hp.json		http://purl.obolibrary.org/obo/CL_0002320		
CL:0002321	biolink:Cell	embryonic cell (metazoa)	A cell of the embryo.	FMA:82841|FMA:82840|WBbt:0007028|CALOHA:TS-0263	hp.json		http://purl.obolibrary.org/obo/CL_0002321		
GO:0023056	biolink:BiologicalProcess	positive regulation of signaling	Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.		hp.json	positive regulation of signalling process|positive regulation of signaling process	http://purl.obolibrary.org/obo/GO_0023056		
HP:0032181	biolink:PhenotypicFeature	Anomalous hepatic venous drainage into the left atrium	An abnormality of the hepatic veins, which normally drain de-oxygenated blood from the liver into the inferior vena cava, whereby the hepatic veins drain into the left atrium.		hp.json		http://purl.obolibrary.org/obo/HP_0032181		
HP:0032182	biolink:PhenotypicFeature	Abnormal proportion of memory T cells	An abnormal proportion of memory T cells compared to the total number of T cells in the blood. Memory T cells have previously encountered and responded to their cognate antigen and upon a repeated encounter with the antigen can mount a faster and stronger response.		hp.json	Abnormal proportion of CD4+CD29+ cells	http://purl.obolibrary.org/obo/HP_0032182		
HP:0032183	biolink:PhenotypicFeature	Decreased proportion of memory T cells	An abnormally reduced proportion of memory T cells compared to the total number of T cells in the blood.		hp.json	Decreased proportion of CD4+CD29+ cells	http://purl.obolibrary.org/obo/HP_0032183		
GO:0023057	biolink:BiologicalProcess	negative regulation of signaling	Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.		hp.json	negative regulation of signalling process|negative regulation of signaling process	http://purl.obolibrary.org/obo/GO_0023057		
HP:0032184	biolink:PhenotypicFeature	Increased proportion of memory T cells	An abnormally elevated proportion of memory T cells compared to the total number of T cells in the blood.		hp.json	Increased proportion of CD4+CD29+ cells	http://purl.obolibrary.org/obo/HP_0032184		
GO:0050657	biolink:BiologicalProcess	nucleic acid transport	The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0050657		
GO:0106027	biolink:BiologicalProcess	neuron projection organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a neuron, e.g. an axon, or a dendrite.		hp.json		http://purl.obolibrary.org/obo/GO_0106027		
GO:0050658	biolink:BiologicalProcess	RNA transport	The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0050658		
HP:0032180	biolink:PhenotypicFeature	Abnormal circulating metabolite concentration	An abnormal level of an analyte measured in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0032180		
HP:0032189	biolink:PhenotypicFeature	Cellular hypersensitivity to diepoxybutane	An increased cellular sensitivity to the DNA cross-linking agent, diepoxybutane (DEB). In the presence of increased sensitivity, DEB causes cell death, chromosome breakage, and accumulation in the G2 phase of the cell cycle.		hp.json		http://purl.obolibrary.org/obo/HP_0032189		
HP:0032185	biolink:PhenotypicFeature	Disseminated molluscum contagiosum	The presense of molluscum contagiosum lesions across multiple areas of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0032185		
GO:0023052	biolink:BiologicalProcess	signaling	The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.		hp.json	single organism signaling|signalling|biological signaling|signaling process|signalling process	http://purl.obolibrary.org/obo/GO_0023052		goslim_mouse|goslim_yeast|goslim_agr|goslim_generic|prokaryote_subset|goslim_pombe|goslim_flybase_ribbon
GO:0023051	biolink:BiologicalProcess	regulation of signaling	Any process that modulates the frequency, rate or extent of a signaling process.		hp.json	regulation of signaling process|regulation of signalling process	http://purl.obolibrary.org/obo/GO_0023051		
HP:0032186	biolink:PhenotypicFeature	Anal neoplasm	A benign or malignant neoplasm that affects the anal canal or anal margin.		hp.json		http://purl.obolibrary.org/obo/HP_0032186		
HP:0032187	biolink:PhenotypicFeature	Anal intraepithelial neoplasia	Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer.		hp.json		http://purl.obolibrary.org/obo/HP_0032187		
HP:0032188	biolink:PhenotypicFeature	Cellular hypersensitivity to mitomycin C	An increased cellular sensitivity to the DNA cross-linking agent, mitomycin C (MMC). In the presence of increased sensitivity, MMC causes increased cell death, chromosome breakage, and accumulation in the G2 phase of the cell cycle.		hp.json		http://purl.obolibrary.org/obo/HP_0032188		
CL:0002333	biolink:Cell	neural crest derived fat cell	A fat cell derived from a neural crest cell.		hp.json		http://purl.obolibrary.org/obo/CL_0002333		
CL:0002336	biolink:Cell	buccal mucosa cell	An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek.		hp.json		http://purl.obolibrary.org/obo/CL_0002336		
HP:0007390	biolink:PhenotypicFeature	Hyperkeratosis with erythema		UMLS:C4024891	hp.json		http://purl.obolibrary.org/obo/HP_0007390		
HP:0007392	biolink:PhenotypicFeature	Excessive wrinkled skin		UMLS:C4024890	hp.json	Excessive wrinkled skin	http://purl.obolibrary.org/obo/HP_0007392		
HP:0032355	biolink:PhenotypicFeature	Decreased peak expiratory flow	A reduction in the maximum expiratory flow per minute, which can be used to measure how fast a subject can exhale as well as to judge the strength of the expiratory muscles and the condition of the large airways.		hp.json		http://purl.obolibrary.org/obo/HP_0032355		
HP:0032356	biolink:PhenotypicFeature	Decreased pre-bronchodilator forced vital capacity	An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed before the administration of a bronchodilating medication.		hp.json	Decreased prebronchodilator forced vital capacity|Decreased pre bronchodilator forced vital capacity	http://purl.obolibrary.org/obo/HP_0032356		
HP:0032357	biolink:PhenotypicFeature	Decreased post-bronchodilator forced vital capacity	An abnormal reduction in the amount of air a person can expel following maximal insipiration, with the test being performed after the administration of a bronchodilating medication.		hp.json	Decreased postbronchodilator forced vital capacity|Decreased post bronchodilator forced vital capacity	http://purl.obolibrary.org/obo/HP_0032357		
HP:0032350	biolink:PhenotypicFeature	Sulfocysteinuria	A increased concentration of sulfocysteine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032350		
CL:1000458	biolink:Cell	melanocyte of skin	A melanocyte that is part of the skin of body.	FMA:72144|CALOHA:TS-2374	hp.json	skin melanocyte	http://purl.obolibrary.org/obo/CL_1000458		
HP:0032351	biolink:PhenotypicFeature	Phenylalaninuria	Increased level of phenylalanine in urine.		hp.json	Increased level of phenylalanine in urine	http://purl.obolibrary.org/obo/HP_0032351		
HP:0032352	biolink:PhenotypicFeature	Methioninuria	Increased level of methionine in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032352		
CL:1000457	biolink:Cell	mesothelial cell of visceral peritoneum	A mesothelial cell that is part of the visceral peritoneum.	FMA:72143	hp.json		http://purl.obolibrary.org/obo/CL_1000457		
HP:0032353	biolink:PhenotypicFeature	Leucinuria	Increased level of leucine in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032353		
CL:1000456	biolink:Cell	mesothelial cell of parietal peritoneum	A mesothelial cell that is part of the parietal peritoneum.	FMA:72142	hp.json		http://purl.obolibrary.org/obo/CL_1000456		
GO:0001819	biolink:BiologicalProcess	positive regulation of cytokine production	Any process that activates or increases the frequency, rate or extent of production of a cytokine.		hp.json	upregulation of cytokine production|positive regulation of cytokine biosynthetic process|up-regulation of cytokine production|positive regulation of cytokine secretion|up regulation of cytokine production|activation of cytokine production|stimulation of cytokine production	http://purl.obolibrary.org/obo/GO_0001819		
HP:0032358	biolink:PhenotypicFeature	Decreased post-bronchodilator forced expiratory volume in one second	An abnormal reduction in the amount of air a person can forcefully expel in one second, with the test being performed after the administration of a bronchodilating medication.		hp.json	Decreased postbronchodilator forced expiratory volume in one second|Decreased post bronchodilator forced expiratory volume in one second	http://purl.obolibrary.org/obo/HP_0032358		
HP:0032359	biolink:PhenotypicFeature	Decreased forced expiratory flow 25-75%	A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled.		hp.json	Decreased FEF25-75%	http://purl.obolibrary.org/obo/HP_0032359		
HP:0007387	biolink:PhenotypicFeature	Hypoplastic sweat glands	Underdevelopment of the sweat glands.	UMLS:C1832455	hp.json	Underdeveloped sweat glands	http://purl.obolibrary.org/obo/HP_0007387		
GO:0001816	biolink:BiologicalProcess	cytokine production	The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.		hp.json	cytokine secretion|interleukin production|interferon production|interleukin secretion|cytokine metabolic process|cytokine biosynthetic process|interferon secretion	http://purl.obolibrary.org/obo/GO_0001816		gocheck_do_not_annotate|goslim_pir
GO:0001817	biolink:BiologicalProcess	regulation of cytokine production	Any process that modulates the frequency, rate, or extent of production of a cytokine.		hp.json	regulation of cytokine biosynthesis|regulation of cytokine anabolism|regulation of cytokine synthesis|regulation of cytokine formation|regulation of cytokine biosynthetic process|regulation of cytokine secretion	http://purl.obolibrary.org/obo/GO_0001817		
GO:0001818	biolink:BiologicalProcess	negative regulation of cytokine production	Any process that stops, prevents, or reduces the rate of production of a cytokine.		hp.json	down regulation of cytokine production|negative regulation of cytokine secretion|inhibition of cytokine biosynthetic process|downregulation of cytokine biosynthetic process|inhibition of cytokine production|downregulation of cytokine production|negative regulation of cytokine biosynthetic process|negative regulation of cytokine anabolism|negative regulation of cytokine biosynthesis|negative regulation of cytokine synthesis|down-regulation of cytokine biosynthetic process|down-regulation of cytokine production|down regulation of cytokine biosynthetic process|negative regulation of cytokine formation	http://purl.obolibrary.org/obo/GO_0001818		
HP:0007383	biolink:PhenotypicFeature	Congenital localized absence of skin		UMLS:C2673597	hp.json	Congenital localised skin absence|Congenital localised absence of skin|Congenital localized skin absence	http://purl.obolibrary.org/obo/HP_0007383		
HP:0007384	biolink:PhenotypicFeature	Aberrant melanosome maturation		UMLS:C1969516	hp.json		http://purl.obolibrary.org/obo/HP_0007384		
HP:0007385	biolink:PhenotypicFeature	Aplasia cutis congenita of scalp	A developmental defect resulting in the congenital absence of skin on the scalp.	UMLS:C1855698|UMLS:C4048801|UMLS:C4072858|UMLS:C4072857	hp.json	Focal absence of scalp tissue|Scalp defect|Scalp aplasia cutis congenita|Defect of scalp|Solitary scalp defect	http://purl.obolibrary.org/obo/HP_0007385		hposlim_core
GO:0001820	biolink:BiologicalProcess	serotonin secretion	The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.		hp.json	5-HT secretion|5-hydroxytryptamine secretion|serotonin release	http://purl.obolibrary.org/obo/GO_0001820		
HP:0032360	biolink:PhenotypicFeature	Decreased pre-bronchodilator forced expiratory flow 25-75%	A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled. Here, the test is performed before the administration of a bronchodilating medication.		hp.json	Decreased pre bronchodilator forced expiratory flow 25-75%|Decreased pre-bronchodilator FEF25-75%|Decreased prebronchodilator forced expiratory flow 25-75%	http://purl.obolibrary.org/obo/HP_0032360		
HP:0032365	biolink:PhenotypicFeature	Exacerbated by aspirin ingestion	Applied to a sign or symptom that is worsened by ingestion of aspirin.		hp.json		http://purl.obolibrary.org/obo/HP_0032365		
HP:0032366	biolink:PhenotypicFeature	Positive direct antiglobulin test	A positive result of the direct antiglobulin test (DAT), a method of demonstrating the presence of antibody or complement bound to red blood cell (RBC) membranes by the use of anti-human globulin to form a visible agglutination reaction.		hp.json		http://purl.obolibrary.org/obo/HP_0032366		
HP:0032367	biolink:PhenotypicFeature	Abnormal growth hormone level	Any deviation from the normal level of growth hormone (GH) in the blood circulation. GH or somatotropin is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration. Its secretion from the pituitary is regulated by the neurosecretory nuclei of the hypothalamus, which can release Growth hormone-releasing hormone (GHRH or somatocrinin) and Growth hormone-inhibiting hormone (GHIH or somatostatin) into the hypophyseal portal venous blood surrounding the pituitary. GH is secreted in a pulsatile manner, which is one of the reasons why an isolated measurement of its blood concentration is not meaningful.		hp.json	Abnormal somatotropin level	http://purl.obolibrary.org/obo/HP_0032367		
HP:0032368	biolink:PhenotypicFeature	Acidemia	An abnormally low blood pH (usually defined as less than 7.35).		hp.json		http://purl.obolibrary.org/obo/HP_0032368		
CHEBI:25585	biolink:ChemicalSubstance	nonmetal atom			hp.json	nonmetal|Nichtmetalle|nonmetal|nonmetals|Nichtmetall|non-metaux|no metal|non-metal|no metales	http://purl.obolibrary.org/obo/CHEBI_25585		3_STAR
HP:0032361	biolink:PhenotypicFeature	Decreased post-bronchodilator forced expiratory flow 25-75%	A reduction compared to the predicted value of the forced expiratory flow over the middle one-half of the FVC; the average flow from the point at which 25% of the FVC has been exhaled to the point at which 75% of the FVC has been exhaled. Here, the test is performed after the administration of a bronchodilating medication.		hp.json	Decreased post bronchodilator forced expiratory flow 25-75%|Decreased post-bronchodilator FEF25-75%|Decreased postbronchodilator forced expiratory flow 25-75%	http://purl.obolibrary.org/obo/HP_0032361		
CL:1000447	biolink:Cell	epithelial cell of stratum germinativum of esophagus	A basal cell that is part of the epithelium of esophagus.	FMA:70731	hp.json	basal cell of esophageal epithelium	http://purl.obolibrary.org/obo/CL_1000447		
HP:0032362	biolink:PhenotypicFeature	Increased circulating corticosterone level	An abnormally elevated concentration of corticosterone in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0032362		
HP:0032363	biolink:PhenotypicFeature	Decreased circulating corticosterone level	An abnormally reduced concentration of corticosterone in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0032363		
HP:0032364	biolink:PhenotypicFeature	obsolete Abnormal CSF amino acid level			hp.json		http://purl.obolibrary.org/obo/HP_0032364		
CL:1000444	biolink:Cell	mesothelial cell of anterior chamber of eye	A mesothelial cell that is part of the anterior chamber of eyeball.	FMA:70615	hp.json		http://purl.obolibrary.org/obo/CL_1000444		
CL:1000443	biolink:Cell	ciliary muscle cell	A smooth muscle cell that is part of the ciliary body.	FMA:70610	hp.json	smooth muscle cell of ciliary body	http://purl.obolibrary.org/obo/CL_1000443		
HP:0032369	biolink:PhenotypicFeature	Alkalemia	An abnormally high blood pH (usually defined as 7.41 or above).		hp.json		http://purl.obolibrary.org/obo/HP_0032369		
GO:0001826	biolink:BiologicalProcess	inner cell mass cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.		hp.json		http://purl.obolibrary.org/obo/GO_0001826		
HP:0007398	biolink:PhenotypicFeature	Asymmetric, linear skin defects		UMLS:C4024888	hp.json		http://purl.obolibrary.org/obo/HP_0007398		
GO:0001829	biolink:BiologicalProcess	trophectodermal cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.		hp.json	trophectoderm cell differentiation	http://purl.obolibrary.org/obo/GO_0001829		
HP:0007394	biolink:PhenotypicFeature	Prominent superficial blood vessels		UMLS:C1848771	hp.json	Prominent superficial blood vessels|Prominent superficial vasculature	http://purl.obolibrary.org/obo/HP_0007394		
HP:0007395	biolink:PhenotypicFeature	Postnatal-onset ichthyosiform erythroderma	A type of ichthyosiform erythroderma with postnatal onset.	UMLS:C4021576	hp.json	Postnatal-onset ichthyosis	http://purl.obolibrary.org/obo/HP_0007395		
GO:0001824	biolink:BiologicalProcess	blastocyst development	The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.		hp.json		http://purl.obolibrary.org/obo/GO_0001824		
HP:0007396	biolink:PhenotypicFeature	Early cutaneous photosensitivity	Photosensitivity of the skin occurring early in life.	UMLS:C4024889	hp.json	Sun sensitivity occurring early in life	http://purl.obolibrary.org/obo/HP_0007396		
HP:0007397	biolink:PhenotypicFeature	Axillary apocrine gland hypoplasia	Developmental hypoplasia of the apocrine sweat glands in the region of the axilla.	UMLS:C1867003	hp.json		http://purl.obolibrary.org/obo/HP_0007397		
GO:0001825	biolink:BiologicalProcess	blastocyst formation	The initial formation of a blastocyst from a solid ball of cells known as a morula.		hp.json		http://purl.obolibrary.org/obo/GO_0001825		
CHEBI:25555	biolink:ChemicalSubstance	nitrogen atom		WebElements:N	hp.json	nitrogeno|N|Stickstoff|nitrogen|nitrogen|7N|azote	http://purl.obolibrary.org/obo/CHEBI_25555		3_STAR
HP:0007370	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the corpus callosum	Absence or underdevelopment of the corpus callosum.	UMLS:C1861866	hp.json	Complete or partial absence of the corpus callosum|Hypoplasia or absence of the corpus callosum|Absent/hypoplastic corpus callosum|Agenesis/hypoplastic corpus callosum|Hypoplastic or absent corpus callosum	http://purl.obolibrary.org/obo/HP_0007370		
HP:0032370	biolink:PhenotypicFeature	Blood group A	ABO phenotype A, corresponding to the genotype AO or AA.		hp.json		http://purl.obolibrary.org/obo/HP_0032370		
HP:0032371	biolink:PhenotypicFeature	Isoleucinuria	An increased concentration of isoleucine in the urine.		hp.json	Hyperisoleucinuria	http://purl.obolibrary.org/obo/HP_0032371		
HP:0007371	biolink:PhenotypicFeature	Corpus callosum atrophy	The presence of atrophy (wasting) of the corpus callosum.	UMLS:C0431370|SNOMEDCT_US:253142006	hp.json	Atrophic corpus callosum|Atrophy/Degeneration of the corpus callosum|Atrophy of the corpus callosum	http://purl.obolibrary.org/obo/HP_0007371		
HP:0032376	biolink:PhenotypicFeature	Anti-beta 2 glycoprotein I antibody positivity	Presence of antibodies against beta 2 glycoprotein I in the circulation. Beta-2 glycoprotein I (beta2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome (APS).		hp.json	Anti-B2GPI positivity	http://purl.obolibrary.org/obo/HP_0032376		
HP:0032377	biolink:PhenotypicFeature	Increased urinary orosomucoid	An increased concentration in the urine of alpha-1-acid glycoprotein (AGP), also known as orosomucoid (ORM). AGP is a 41-43-kDa glycoprotein with a pI of 2.8-3.8. AGP is an acute-phase protein that has many activities including, but not limited to, acting as an acute-phase reactant and disease marker, modulating immunity, binding and carrying drugs, maintaining the barrier function of capillary, and mediating the sphingolipid metabolism.		hp.json	Increased urinary alpha-1-acid glycoprotein	http://purl.obolibrary.org/obo/HP_0032377		
HP:0032378	biolink:PhenotypicFeature	Immediate-type hypersensitivity drug reaction	Hypersensitivity that is observed within 1 hr of exposures. A variety of adverse reactions can occur within minutes to hours of exposure to a drug. Some can be related to the pharmacological action of the drug (WHO Adverse Reaction Terminology type A for augmented) and usually have a low mortality. Others are not readily predictable based on the structure and pharmacological action of the drug and have a relatively high mortality risk (Type B for bizarre). The most serious form of immediate onset drug hypersensitivity reaction, anaphylaxis. Other reactions including itching,dizziness/light-headedness, nausea, chest discomfort but without any objective skin features, physical signs or physiological compromise. Skin only reactions include generalized erythema, urticaria or angioedema without any sentinel features (see below) of other organ involvement.		hp.json		http://purl.obolibrary.org/obo/HP_0032378		
UBERON:0036553	biolink:AnatomicalEntity	wall of synovial tendon sheath		FMA:231590	hp.json		http://purl.obolibrary.org/obo/UBERON_0036553		
HP:0032379	biolink:PhenotypicFeature	Polymorphous light eruption	The cardinal symptom is severely pruritic skin lesions. Macular, papular, papulovesicular, urticarial, multiforme- and plaque-like variants are differentiated morphologically, hence the name polymorphous. Usually one morphology dominates in a single individual (monomorphous). The skin lesions develop a few hours to several days after sun exposure. Initially, patchy erythema develops, accompanied by pruritus. Distinct lesions then develop. The upper chest, upper arms, backs of the hands, thighs, and the sides of the face are the primary localizations. The skin lesions resolve spontaneously within several days of ceasing sun exposure and do not leave behind any traces.		hp.json	Sun allergy	http://purl.obolibrary.org/obo/HP_0032379		
HP:0032372	biolink:PhenotypicFeature	Increased peripheral blast count	An increased count in the peripheral blood of cells that are precursors to mature circulating blood cells such as neutrophiles, monocytes, lymphocutes, and erythrocytes. Blasts are not usually found in significant numbers in the peripheral blood circulation, but can be observed in hematopoietic neoplasms such as leukemia, severe infections, and as a result of certain medications.		hp.json	Increased peripheral myeloblast count|Elevated blast count|Elevated circulating blasts	http://purl.obolibrary.org/obo/HP_0032372		
HP:0032373	biolink:PhenotypicFeature	Duffy blood group	The Duffy blood group system is based on the presence of a glycoprotein termed Fy that is on the surface of erythrocytes and some other cells. There are two Duffy antigens named Fya and Fyb, and thus there are four Duffy phenotypes: a+b+, a+b-, a-b+,a-b-.		hp.json		http://purl.obolibrary.org/obo/HP_0032373		
HP:0032374	biolink:PhenotypicFeature	Duffy Fya positivity	Presence of the Duffy Fya antigen.		hp.json		http://purl.obolibrary.org/obo/HP_0032374		
CL:1000479	biolink:Cell	Purkinje myocyte of atrioventricular node	A Purkinje myocyte that is part of the atrioventricular node.	FMA:83386	hp.json		http://purl.obolibrary.org/obo/CL_1000479		
HP:0032375	biolink:PhenotypicFeature	Duffy Fyb positivity	Presence of the Duffy Fyb antigen.		hp.json		http://purl.obolibrary.org/obo/HP_0032375		
CL:1000478	biolink:Cell	transitional myocyte of sinoatrial node	A transitional myocyte that is part of the sinoatrial node.	FMA:83384	hp.json	transitinal myocyte of sinuatrial node	http://purl.obolibrary.org/obo/CL_1000478		
HP:0007369	biolink:PhenotypicFeature	Atrophy/Degeneration affecting the cerebrum	The presence of atrophy (wasting) of the cerebrum, also known as the telencephalon, the largest and most highly developed part of the human brain.	UMLS:C4024898	hp.json		http://purl.obolibrary.org/obo/HP_0007369		
HP:0007365	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the corticospinal tracts		UMLS:C4024901	hp.json		http://purl.obolibrary.org/obo/HP_0007365		
HP:0007366	biolink:PhenotypicFeature	Atrophy/Degeneration affecting the brainstem		UMLS:C4024900	hp.json	Brainstem atrophy	http://purl.obolibrary.org/obo/HP_0007366		
HP:0007367	biolink:PhenotypicFeature	Atrophy/Degeneration affecting the central nervous system		UMLS:C4024899	hp.json	Atrophy/Degeneration affecting the CNS	http://purl.obolibrary.org/obo/HP_0007367		
HP:0007361	biolink:PhenotypicFeature	Abnormal pons morphology	A structural abnormality of the pons.	UMLS:C4024905	hp.json	Abnormality of the pons	http://purl.obolibrary.org/obo/HP_0007361		
HP:0007362	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the brainstem		UMLS:C4024904	hp.json	Absent/small brainstem|Absent/underdeveloped brainstem	http://purl.obolibrary.org/obo/HP_0007362		
ENVO:00000446	biolink:NamedThing	terrestrial biome			hp.json		http://purl.obolibrary.org/obo/ENVO_00000446		
HP:0007363	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the pyramidal tract		UMLS:C4024903	hp.json		http://purl.obolibrary.org/obo/HP_0007363		
HP:0007364	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the cerebrum		UMLS:C4024902	hp.json	Absent/underdeveloped cerebrum|Absent/small cerebrum	http://purl.obolibrary.org/obo/HP_0007364		
HP:0007380	biolink:PhenotypicFeature	Facial telangiectasia	Telangiectases (small dilated blood vessels) located near the surface of the skin of the face.	UMLS:C0858684	hp.json	Facial telangiectatic vessels|Telangiectasia, facial	http://purl.obolibrary.org/obo/HP_0007380		
HP:0007381	biolink:PhenotypicFeature	Congenital exfoliative erythroderma		UMLS:C4024892	hp.json		http://purl.obolibrary.org/obo/HP_0007381		
HP:0032381	biolink:PhenotypicFeature	Hydroa vacciniforme	In response to the spring sun distinct inflamed reddened skin develops on the ears, nose, cheeks, fingers, backs of the hands, and the lower arms, on which blisters with serous or hemorrhagic content develop. These dry out with the formation of a blackish scab. After shedding of the scab, depressed, varioliform, often hypopigmented scars remain. In addition, hyper- and hypopigmentation are present together, resulting in a polymorphous skin presentation.		hp.json	Acute vesiculation and crusting and scarring following sun exposure	http://purl.obolibrary.org/obo/HP_0032381		
HP:0032382	biolink:PhenotypicFeature	Uniparental disomy	Inheritance of both homologues of a chromosome pair from the same parent.		hp.json	UPD	http://purl.obolibrary.org/obo/HP_0032382		
CHEBI:50505	biolink:ChemicalSubstance	sweetening agent	Substance that sweeten food, beverages, medications, etc.		hp.json	sweeteners|sweetener	http://purl.obolibrary.org/obo/CHEBI_50505		3_STAR
CHEBI:50503	biolink:ChemicalSubstance	laxative	An agent that produces a soft formed stool, and relaxes and loosens the bowels, typically used over a protracted period, to relieve constipation. Compare with cathartic, which is a substance that accelerates defecation. A substances can be both a laxative and a cathartic.		hp.json	laxante|laxatives|aperient|purgative|purgatives|aperients	http://purl.obolibrary.org/obo/CHEBI_50503		3_STAR
HP:0032387	biolink:PhenotypicFeature	Reduced circulating transferrin concentration	An abnormally decreased concentration of transferrin in the blood circulation.		hp.json	Reduced transferrin level	http://purl.obolibrary.org/obo/HP_0032387		
HP:0032388	biolink:PhenotypicFeature	Periventricular nodular heterotopia	Nodules of heterotopia along the ventricular walls. There can be a single nodule or a large number of nodules, they can exist on either or both sides of the brain at any point along the higher ventricle margins, they can be small or large, single or multiple.		hp.json		http://purl.obolibrary.org/obo/HP_0032388		
HP:0032389	biolink:PhenotypicFeature	Periventricular laminar heterotopia	A large mass of heterotopia in a laminar configuration along the ventricular walls. Usually bilateral.		hp.json		http://purl.obolibrary.org/obo/HP_0032389		
HP:0032383	biolink:PhenotypicFeature	Uniparental heterodisomy	A type of uniparental disomy in which the two different chromosomes (or chromosome segments) of the same parent are transmitted.		hp.json		http://purl.obolibrary.org/obo/HP_0032383		
HP:0032384	biolink:PhenotypicFeature	Uniparental isodisomy	A type of uniparental disomy in which the two identical chromosomes (or chromosome segments) of the same parent are transmitted.		hp.json		http://purl.obolibrary.org/obo/HP_0032384		
HP:0032385	biolink:PhenotypicFeature	Abnormal circulating transferrin concentration	Any deviation from the normal concentration of transferrin in the blood circulation.		hp.json	Abnormal circulating transferrin level	http://purl.obolibrary.org/obo/HP_0032385		
HP:0032386	biolink:PhenotypicFeature	Elevated circulating transferrin concentration	An abnormally increased concentration of transferrin in the blood circulation.		hp.json	Elevated transferrin level	http://purl.obolibrary.org/obo/HP_0032386		
CHEBI:86508	biolink:ChemicalSubstance	alpha-aminobutyrate	An alpha-amino-acid anion that is the  conjugate base of alpha-aminobutyric acid.	PMID:24023812	hp.json	2-aminobutanoate	http://purl.obolibrary.org/obo/CHEBI_86508		3_STAR
HP:0007376	biolink:PhenotypicFeature	Abnormal choroid plexus morphology	An abnormality of the choroid plexus, which is the area in the cerebral ventricles in which cerebrospinal fluid is produced by modified ependymal cells.	UMLS:C4024893	hp.json		http://purl.obolibrary.org/obo/HP_0007376		
HP:0007377	biolink:PhenotypicFeature	Abnormality of somatosensory evoked potentials	An abnormality of somatosensory evoked potentials (SSEP), i.e., of the electrical signals of sensation going from the body to the brain in response to a defined stimulus. Recording electrodes are placed over the scalp, spine, and peripheral nerves proximal to the stimulation site. Clinical studies generally use electrical stimulation of peripheral nerves to elicit potentials. SSEP testing determines whether peripheral sensory nerves are able to transmit sensory information like pain, temperature, and touch to the brain. Abnormal SSEPs can result from dysfunction at the level of the peripheral nerve, plexus, spinal root, spinal cord, brain stem, thalamocortical projections, or primary somatosensory cortex.	UMLS:C4021577	hp.json	Abnormality of SSEPs	http://purl.obolibrary.org/obo/HP_0007377		
HP:0007378	biolink:PhenotypicFeature	Neoplasm of the gastrointestinal tract	A tumor (abnormal growth of tissue) of the gastrointestinal tract.	MSH:D005770|NCIT:C3262|UMLS:C0017185|SNOMEDCT_US:126768004	hp.json	GI tract tumour|Gastrointestinal tract tumor|Gastrointestinal tract neoplasm|GI tract tumor|Gastrointestinal tract neoplasia|Neoplasm of the GI tract|Gastrointestinal tract tumour	http://purl.obolibrary.org/obo/HP_0007378		
HP:0007379	biolink:PhenotypicFeature	Neoplasm of the genitourinary tract	A tumor (abnormal growth of tissue) of the genitourinary system.	UMLS:C0042065|NCIT:C3262|UMLS:C4020809|MSH:D014565	hp.json	Neoplasm of the GU tract|Genitourinary tract tumours|Genitourinary tract tumors|Genitourinary tract neoplasm|Genitourinary tract neoplasia	http://purl.obolibrary.org/obo/HP_0007379		
HP:0007372	biolink:PhenotypicFeature	Atrophy/Degeneration involving the corticospinal tracts		UMLS:C4024897	hp.json		http://purl.obolibrary.org/obo/HP_0007372		
HP:0007373	biolink:PhenotypicFeature	Motor neuron atrophy	Wasting involving the motor neuron.	UMLS:C4024896	hp.json	Motor neuron degeneration	http://purl.obolibrary.org/obo/HP_0007373		
HP:0007374	biolink:PhenotypicFeature	Atrophy/Degeneration involving the caudate nucleus		UMLS:C4024895	hp.json		http://purl.obolibrary.org/obo/HP_0007374		
HP:0007375	biolink:PhenotypicFeature	Abnormal septum pellucidum morphology	An abnormality of the septum pellucidum, which is a thin, triangular, vertical membrane separating the lateral ventricles of the brain.	UMLS:C4024894	hp.json	Abnormality of the septum pellucidum	http://purl.obolibrary.org/obo/HP_0007375		
HP:0032310	biolink:PhenotypicFeature	Granulocytosis	An increased count of granulocytes in the peripheral blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032310		
HP:0032311	biolink:PhenotypicFeature	Increased circulating globulin level	An abnormally elevated concentration of globulins in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0032311		
HP:0032312	biolink:PhenotypicFeature	Decreased circulating globulin level	An abnormally reduced concentration of globulins in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0032312		
HP:0032313	biolink:PhenotypicFeature	Frontotemporal hypertrichosis	Excessive, increased hair growth located in the region of the forehead and temple.		hp.json		http://purl.obolibrary.org/obo/HP_0032313		
CL:1000414	biolink:Cell	endothelial cell of venule	An endothelial cell that is part of the venule.	FMA:67762	hp.json		http://purl.obolibrary.org/obo/CL_1000414		
CL:1000413	biolink:Cell	endothelial cell of artery	A blood vessel endothelial cell that is part of an arterial endothelium.	KUPO:0001095|BTO:0004758|FMA:67761	hp.json	arterial endothelial cell	http://purl.obolibrary.org/obo/CL_1000413		
CL:1000412	biolink:Cell	endothelial cell of arteriole	An endothelial cell that is part of the arteriole.	KUPO:0001097|FMA:67760	hp.json		http://purl.obolibrary.org/obo/CL_1000412		
HP:0032318	biolink:PhenotypicFeature	Family history of heart disease	A close blood relative had heart disease.		hp.json		http://purl.obolibrary.org/obo/HP_0032318		
CL:1000410	biolink:Cell	myocyte of atrioventricular node	A muscle cell that is part of the atrioventricular node.	FMA:67106	hp.json	atrioventricular node myocyte|atrioventricular node cell|AV node cardiac muscle cell|AV nodal myocyte|AV node cell	http://purl.obolibrary.org/obo/CL_1000410		
CL:0002187	biolink:Cell	basal cell of epidermis	A basally situated, mitotically active, columnar-shaped keratinocyte attached to the basement membrane.	FMA:70571	hp.json		http://purl.obolibrary.org/obo/CL_0002187		
HP:0032319	biolink:PhenotypicFeature	Health status	Health status of a family member with respect to the disease being investigated in a proband.		hp.json		http://purl.obolibrary.org/obo/HP_0032319		
HP:0032314	biolink:PhenotypicFeature	Abnormal areolar morphology	An abnormal appearance or structure of the ring of pigmented skin that surrounds the nipple.		hp.json		http://purl.obolibrary.org/obo/HP_0032314		
HP:0032315	biolink:PhenotypicFeature	Areolar fullness	The areola (ring of pigmented skin surrounding the nipple) is filled out so as to produce a rounded shape.		hp.json		http://purl.obolibrary.org/obo/HP_0032315		
HP:0032316	biolink:PhenotypicFeature	Family history	Information about close relatives of an individual who is the proband of a study or who is being investigated with the goal of identifying a medical diagnosis. Usually, the family history includes information from three generations of relatives, including children, brothers and sisters, parents, aunts and uncles, nieces and nephews, grandparents, and cousins.		hp.json		http://purl.obolibrary.org/obo/HP_0032316		
HP:0032317	biolink:PhenotypicFeature	Family history of cancer	A close blood relative had cancer.		hp.json		http://purl.obolibrary.org/obo/HP_0032317		
CL:0002180	biolink:Cell	mucous cell of stomach	A mucous cell in the epithelium of the stomach.	FMA:63464	hp.json		http://purl.obolibrary.org/obo/CL_0002180		
ENVO:00000428	biolink:NamedThing	biome			hp.json		http://purl.obolibrary.org/obo/ENVO_00000428		
CL:0002183	biolink:Cell	stem cell of gastric gland	A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit.	FMA:62953	hp.json		http://purl.obolibrary.org/obo/CL_0002183		
CL:1000409	biolink:Cell	myocyte of sinoatrial node	A muscle cell that is part of the sinoatrial node.	FMA:67102	hp.json	SA nodal myocyte|myocyte of sinoatrial node|SA node cardiac muscle cell|sinoatrial node myocyte|sinoatrial node cell|sinuatrial node myocyte	http://purl.obolibrary.org/obo/CL_1000409		
HP:0032321	biolink:PhenotypicFeature	Unaffected	This term applies to a family member in whom the diagnosis that is the primary focus of investigation is excluded.		hp.json		http://purl.obolibrary.org/obo/HP_0032321		
HP:0032322	biolink:PhenotypicFeature	Healthy	No history of any serious disease, including the disease being investigated in the proband.		hp.json		http://purl.obolibrary.org/obo/HP_0032322		
HP:0032323	biolink:PhenotypicFeature	Periodic fever	Episodic fever that recurs at regular intervals.		hp.json		http://purl.obolibrary.org/obo/HP_0032323		
HP:0032324	biolink:PhenotypicFeature	Non-periodic recurrent fever	Episodic fever that recurs at irregular intervals.		hp.json		http://purl.obolibrary.org/obo/HP_0032324		
HP:0032320	biolink:PhenotypicFeature	Affected	This term applies to a family member who is diagnosed with the same condition as the individual who is the primary focus of investigation (the proband).		hp.json		http://purl.obolibrary.org/obo/HP_0032320		
CL:0002199	biolink:Cell	oxyphil cell of parathyroid gland	An oncocyte located in the parathyroid gland.	FMA:69084	hp.json		http://purl.obolibrary.org/obo/CL_0002199		
HP:0032329	biolink:PhenotypicFeature	Increased urinary 11-deoxycortisol level	An abnormally elevated concentration of 11-deoxycortisol in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032329		
CL:0002198	biolink:Cell	oncocyte	A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands.	FMA:67606	hp.json	oxyphil	http://purl.obolibrary.org/obo/CL_0002198		
CHEBI:37527	biolink:ChemicalSubstance	acid	An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid).	KEGG:C00174	hp.json	Acid|acide|acids|acido|Saeure|acid|Saeuren	http://purl.obolibrary.org/obo/CHEBI_37527		3_STAR
HP:0032325	biolink:PhenotypicFeature	Lacunar stroke	A stroke related to a small infarct (2-20 mm in diameter) in the deep cerebral white matter, basal ganglia, or pons, that is presumed to result from the occlusion of a single small perforating artery supplying the subcortical areas of the brain.		hp.json		http://purl.obolibrary.org/obo/HP_0032325		
HP:0032326	biolink:PhenotypicFeature	Methicillin-resistant Staphylococcus aureus infection	Infection with staphylococcus aureus resistant to the antibiotic methicillin (MRSA). MRSA can infect any individual but is more common among hospitalized patients, and can also occur as an opportunistic infection.		hp.json	MRSA infection	http://purl.obolibrary.org/obo/HP_0032326		
HP:0032327	biolink:PhenotypicFeature	Interhemispheric cyst	Cystic collection (sac-like, fluid containing pocket of membranous tissue) located in the interhemispheric fissure, with or without communication with the ventricular system.		hp.json		http://purl.obolibrary.org/obo/HP_0032327		
HP:0032328	biolink:PhenotypicFeature	Temporomandibular joint adhesion	Formation of one or more fibrous bands within the temporomandibular joint (TMJ) with resulting limitation of movement of the TMJ. Adhesions may be seen in degenerative processes that involve the TMJ.		hp.json		http://purl.obolibrary.org/obo/HP_0032328		
CL:0002191	biolink:Cell	granulocytopoietic cell	A cell involved in the formation of a granulocyte.	FMA:83519	hp.json		http://purl.obolibrary.org/obo/CL_0002191		
CL:0002194	biolink:Cell	monopoietic cell	A cell involved in the formation of a monocyte (monopoiesis).	FMA:83552	hp.json		http://purl.obolibrary.org/obo/CL_0002194		
CHEBI:25512	biolink:ChemicalSubstance	neurotransmitter	An endogenous compound that is used to transmit information across the synapse between a neuron and another cell.	Wikipedia:Neurotransmitter	hp.json	neurotransmitters	http://purl.obolibrary.org/obo/CHEBI_25512		3_STAR
GO:0050801	biolink:BiologicalProcess	ion homeostasis	Any process involved in the maintenance of an internal steady state of ions within an organism or cell.		hp.json	electrolyte homeostasis|regulation of ion homeostasis|negative regulation of crystal formation	http://purl.obolibrary.org/obo/GO_0050801		
CHEBI:25513	biolink:ChemicalSubstance	neutral glycosphingolipid	Any glycosphingolipid containing unsubstituted glycosyl moieties.		hp.json	neutral glycosphingolipids	http://purl.obolibrary.org/obo/CHEBI_25513		3_STAR
GO:0050804	biolink:BiologicalProcess	modulation of chemical synaptic transmission	Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.  Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.		hp.json	regulation of chemical synaptic transmission|modulation of synaptic transmission|regulation of synaptic transmission	http://purl.obolibrary.org/obo/GO_0050804		goslim_synapse
HP:0032332	biolink:PhenotypicFeature	Oligoclonal elevation of circulating IgM	An increase in circulating IgM characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase.		hp.json		http://purl.obolibrary.org/obo/HP_0032332		
GO:0050805	biolink:BiologicalProcess	negative regulation of synaptic transmission	Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.		hp.json	down-regulation of synaptic transmission|down regulation of synaptic transmission|inhibition of synaptic transmission|downregulation of synaptic transmission	http://purl.obolibrary.org/obo/GO_0050805		
HP:0032333	biolink:PhenotypicFeature	Polyclonal elevation of circulating IgA	A heterogeneous increase in IgA mmunoglobulins characterized by a diffuse band on serum electrophoresis.		hp.json		http://purl.obolibrary.org/obo/HP_0032333		
HP:0032334	biolink:PhenotypicFeature	Oligoclonal elevation of circulating IgA	An increase in circulating IgA characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.		hp.json		http://purl.obolibrary.org/obo/HP_0032334		
GO:0050802	biolink:BiologicalProcess	circadian sleep/wake cycle, sleep	The part of the circadian sleep/wake cycle where the organism is asleep.		hp.json		http://purl.obolibrary.org/obo/GO_0050802		
HP:0032335	biolink:PhenotypicFeature	Monoclonal elevation of circulating IgA	An increase in circulating IgA characterized by one predominant band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.		hp.json		http://purl.obolibrary.org/obo/HP_0032335		
GO:0050803	biolink:BiologicalProcess	regulation of synapse structure or activity	Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).		hp.json		http://purl.obolibrary.org/obo/GO_0050803		
GO:0050808	biolink:BiologicalProcess	synapse organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).		hp.json	synapse morphogenesis|synapse organisation|synapse development|synapse organization and biogenesis	http://purl.obolibrary.org/obo/GO_0050808		goslim_drosophila|goslim_synapse
GO:0050806	biolink:BiologicalProcess	positive regulation of synaptic transmission	Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.		hp.json	up regulation of synaptic transmission|activation of synaptic transmission|stimulation of synaptic transmission|upregulation of synaptic transmission|up-regulation of synaptic transmission	http://purl.obolibrary.org/obo/GO_0050806		
HP:0032330	biolink:PhenotypicFeature	Increased urinary 11-deoxycorticosterone level	An abnormally elevated concentration or amount of 11-deoxycorticosterone in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032330		
HP:0032331	biolink:PhenotypicFeature	Increased urinary 11-deoxytetrahydrocorticosterone level	An abnormally elevated concentration or amount of 11-deoxytetrahydrocorticosterone the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032331		
GO:0050807	biolink:BiologicalProcess	regulation of synapse organization	Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).		hp.json	regulation of synapse organization and biogenesis|regulation of synapse organisation|regulation of synapse structure	http://purl.obolibrary.org/obo/GO_0050807		goslim_synapse
CL:0002166	biolink:Cell	epithelial cell of Malassez	An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth.	FMA:62987	hp.json	epithelial cell rests of Malassez|epithelial debris of Malassez	http://purl.obolibrary.org/obo/CL_0002166		
OIO:shorthand	biolink:NamedThing	shorthand			hp.json		http://www.geneontology.org/formats/oboInOwl#shorthand		
HP:0032336	biolink:PhenotypicFeature	Increased circulating specific IgE antibody			hp.json		http://purl.obolibrary.org/obo/HP_0032336		
HP:0032337	biolink:PhenotypicFeature	Monoclonal elevation of circulating IgE	An increase in circulating IgE characterized by one predominant band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.		hp.json		http://purl.obolibrary.org/obo/HP_0032337		
HP:0032338	biolink:PhenotypicFeature	Oligoclonal elevation of circulating IgE	An increase in circulating IgE characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.		hp.json		http://purl.obolibrary.org/obo/HP_0032338		
HP:0032339	biolink:PhenotypicFeature	Polyclonal elevation of circulating IgE	A heterogeneous increase in IgE mmunoglobulins characterized by a diffuse band on serum electrophoresis.		hp.json		http://purl.obolibrary.org/obo/HP_0032339		
GO:0050810	biolink:BiologicalProcess	regulation of steroid biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.		hp.json	regulation of steroid synthesis|regulation of steroid formation|regulation of steroid biosynthesis|regulation of steroidogenesis|regulation of steroid anabolism	http://purl.obolibrary.org/obo/GO_0050810		
HP:0032344	biolink:PhenotypicFeature	Upslanting toenail	Upturned concavity of toenails.		hp.json	Ski-jump toenail|Upturned toenail	http://purl.obolibrary.org/obo/HP_0032344		
UBERON:0036521	biolink:AnatomicalEntity	wall of urethra		FMA:19779	hp.json	urethral wall	http://purl.obolibrary.org/obo/UBERON_0036521		
CL:1000428	biolink:Cell	stem cell of epidermis	A somatic stem cell that is part of the epidermis.	FMA:70541	hp.json	epidermal stem cell	http://purl.obolibrary.org/obo/CL_1000428		
HP:0032345	biolink:PhenotypicFeature	Elevated cancer Ag 19-9 level	An abnormal increased in the amount of the carbohydrate antigen 19-9, a recognizable sialo-ganglioside in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032345		
HP:0032346	biolink:PhenotypicFeature	Cutaneous lichen amyloidosis	Lichen amyloidosis presents with multiple localized or rarely generalized, hyperpigmented grouped papules with a predilection for the shins, calves, ankles, and dorsa of the feet and thighs.		hp.json		http://purl.obolibrary.org/obo/HP_0032346		
CL:1000426	biolink:Cell	chromaffin cell of adrenal gland	A chromaffin cell that is part of the adrenal gland.	FMA:69794	hp.json	adrenal chromaffin cell	http://purl.obolibrary.org/obo/CL_1000426		
UBERON:0036523	biolink:AnatomicalEntity	wall of vagina		FMA:19971	hp.json	vaginal wall	http://purl.obolibrary.org/obo/UBERON_0036523		
GO:0050819	biolink:BiologicalProcess	negative regulation of coagulation	Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation.		hp.json	anticoagulant activity|down-regulation of coagulation|down regulation of coagulation|negative regulation of clotting|inhibition of coagulation|downregulation of coagulation	http://purl.obolibrary.org/obo/GO_0050819		
HP:0032340	biolink:PhenotypicFeature	obsolete Abnormal spirometry test			hp.json		http://purl.obolibrary.org/obo/HP_0032340		
GO:0050817	biolink:BiologicalProcess	coagulation	The process in which a fluid solution, or part of it, changes into a solid or semisolid mass.		hp.json	clotting	http://purl.obolibrary.org/obo/GO_0050817		goslim_pir
HP:0032341	biolink:PhenotypicFeature	Reduced forced vital capacity	An abnormal reduction in the amount of air a person can expel following maximal inspiration.		hp.json	Reduced FVC|Decreased forced vital capacity	http://purl.obolibrary.org/obo/HP_0032341		
GO:0050818	biolink:BiologicalProcess	regulation of coagulation	Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass.		hp.json	regulation of clotting	http://purl.obolibrary.org/obo/GO_0050818		
HP:0032342	biolink:PhenotypicFeature	Reduced forced expiratory volume in one second	An abnormal reduction in the amount of air a person can forcefully expel in one second.		hp.json	Reduced FEV1	http://purl.obolibrary.org/obo/HP_0032342		
CL:0002178	biolink:Cell	epithelial cell of stomach	An epithelial cell found in the lining of the stomach.	FMA:62948	hp.json		http://purl.obolibrary.org/obo/CL_0002178		
HP:0032347	biolink:PhenotypicFeature	Cutaneous macular amyloidosis	A type of cutaneous amyloidosis that is characterized by hyperpigmented patches with indefinite margins composed of grayish brown macules, often with a reticulated or rippled appearance. Lesions may present as a hyperpigmented patch composed of small brown macules in a rippled or reticulated pattern.		hp.json	Macular amyloidosis	http://purl.obolibrary.org/obo/HP_0032347		
HP:0032348	biolink:PhenotypicFeature	Cutaneous nodular amyloidosis	A type of cutaneous amyloidosis that is characterized clinically by waxy, purpuric plaques and nodules and histologically by amyloid deposits in the dermis and subcutaneous tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0032348		
HP:0032349	biolink:PhenotypicFeature	Serinuria	A increased concentration of serine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032349		
CL:0002170	biolink:Cell	keratinized cell of the oral mucosa	A keratinized cell located in the hard palate or gingiva.		hp.json		http://purl.obolibrary.org/obo/CL_0002170		
GO:0072175	biolink:BiologicalProcess	epithelial tube formation	The developmental process pertaining to the initial formation of an epithelial tube.		hp.json		http://purl.obolibrary.org/obo/GO_0072175		
GO:0001892	biolink:BiologicalProcess	embryonic placenta development	The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.		hp.json	fetal placenta development	http://purl.obolibrary.org/obo/GO_0001892		
GO:0001894	biolink:BiologicalProcess	tissue homeostasis	A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.		hp.json	tissue maintenance	http://purl.obolibrary.org/obo/GO_0001894		
HP:0010962	biolink:PhenotypicFeature	Extralobar sequestration	A kind of bronchopulmonary sequestration that is completely discrete from the normal lung and is surrounded by separate pleura.	UMLS:C4023626	hp.json		http://purl.obolibrary.org/obo/HP_0010962		
HP:0010961	biolink:PhenotypicFeature	Intralobar sequestration	A kind of bronchopulmonary sequestration that is incorporated into the normal surrounding lung.	UMLS:C4023627	hp.json		http://purl.obolibrary.org/obo/HP_0010961		
HP:0010960	biolink:PhenotypicFeature	Bronchopulmonary sequestration	The presence of microscopic cystic masses of nonfunctioning pulmonary tissue that lack an obvious communication with the tracheobronchial tree.	UMLS:C0006288|MSH:D001998|SNOMEDCT_US:18620009	hp.json		http://purl.obolibrary.org/obo/HP_0010960		
GO:0001890	biolink:BiologicalProcess	placenta development	The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.		hp.json	placentation|placental development	http://purl.obolibrary.org/obo/GO_0001890		
HP:0007307	biolink:PhenotypicFeature	Rapid neurologic deterioration		UMLS:C4024908	hp.json		http://purl.obolibrary.org/obo/HP_0007307		
HP:0010969	biolink:PhenotypicFeature	Abnormality of glycolipid metabolism	An abnormality of glycolipid metabolism.	UMLS:C4023621	hp.json		http://purl.obolibrary.org/obo/HP_0010969		
HP:0009969	biolink:PhenotypicFeature	Partial duplication of the middle phalanx of the 3rd finger	Partial duplication of the middle phalanx of middle finger, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4024138	hp.json	Partial duplication of the middle bone of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009969		
HP:0007308	biolink:PhenotypicFeature	Extrapyramidal dyskinesia		UMLS:C1848528	hp.json		http://purl.obolibrary.org/obo/HP_0007308		
HP:0010968	biolink:PhenotypicFeature	Abnormality of liposaccharide metabolism	An abnormality of liposaccharide metabolism.	UMLS:C4023622	hp.json		http://purl.obolibrary.org/obo/HP_0010968		
PATO:0055003	biolink:NamedThing	increased rate of occurrence	A rate of occurrence that is relatively high.		hp.json		http://purl.obolibrary.org/obo/PATO_0055003		
HP:0010967	biolink:PhenotypicFeature	Abnormal circulating carnitine concentration	Any deviation from the normal concentration of carnitine in the blood circulation.	UMLS:C4021855|UMLS:C4020761	hp.json	Carnitine levels abnormal	http://purl.obolibrary.org/obo/HP_0010967		
PATO:0055004	biolink:NamedThing	decreased rate of occurrence	A rate of occurrence that is relatively low.		hp.json		http://purl.obolibrary.org/obo/PATO_0055004		
HP:0009966	biolink:PhenotypicFeature	Complete duplication of the middle phalanx of the 3rd finger	Complete duplication of the middle phalanx of middle finger.	UMLS:C4024140	hp.json	Complete duplication of the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009966		
HP:0010966	biolink:PhenotypicFeature	Abnormal circulating fatty-acid anion concentration	Any deviation from the normal concentration of a fatty acid anion in the blood circulation.	UMLS:C4021209	hp.json	Abnormality of fatty acid anion	http://purl.obolibrary.org/obo/HP_0010966		
GO:1990917	biolink:CellularComponent	ooplasm	The cytoplasm of an ovum.		hp.json		http://purl.obolibrary.org/obo/GO_1990917		
HP:0010965	biolink:PhenotypicFeature	Abnormal circulating phytanic acid concentration	Any deviation from the normal concentration of phytanic acid in the blood circulation.	UMLS:C4023623	hp.json	Abnormal circulating phytanic acid level	http://purl.obolibrary.org/obo/HP_0010965		
HP:0009965	biolink:PhenotypicFeature	Complete duplication of the distal phalanx of the 3rd finger	Complete duplication of the distal phalanx of middle finger	UMLS:C4024141	hp.json	Complete duplication of the outermost bone of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009965		
HP:0009968	biolink:PhenotypicFeature	Partial duplication of the distal phalanx of the 3rd finger	Partial duplication of the distal phalanx of middle finger, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4021360	hp.json	Bifid terminal phalanx of the 3rd finger|Notched outermost bone of the middle finger|Partial duplication of the outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009968		
HP:0010964	biolink:PhenotypicFeature	Abnormal circulating long-chain fatty-acid concentration	Any deviation from the normal concentration of a long-chain fatty acid in the blood circulation.	UMLS:C4023624	hp.json		http://purl.obolibrary.org/obo/HP_0010964		
HP:0007305	biolink:PhenotypicFeature	CNS demyelination	A loss of myelin from nerve fibers in the central nervous system.	UMLS:C0338474	hp.json	Demyelination in central white matter	http://purl.obolibrary.org/obo/HP_0007305		
HP:0010963	biolink:PhenotypicFeature	Absence of stomach bubble on fetal sonography	By the 14th week of gestation it is nearly always possible to visualized the fluid-filled fetal stomach bubble on prenatal sonography. This term refers to the absence of a normal fetal stomach bubble on fetal ultrasonography performed at around 16 to 20 weeks' gestation.	UMLS:C4023625	hp.json	Absent stomach bubble|Absence of stomach bubble on foetal sonography|Non-visualisation of the fetal stomach	http://purl.obolibrary.org/obo/HP_0010963		
HP:0009967	biolink:PhenotypicFeature	Complete duplication of the proximal phalanx of the 3rd finger	Complete duplication of the third proximal phalanx of hand.	UMLS:C4024139	hp.json	Complete duplication of the innermost bone of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009967		
HP:0009962	biolink:PhenotypicFeature	Duplication of the distal phalanx of the 3rd finger	Partial or complete duplication of the distal phalanx of middle finger.	UMLS:C4021363	hp.json	Partial/complete duplication of the outermost bone of the middle finger|Partial/complete duplication of the distal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009962		
HP:0009961	biolink:PhenotypicFeature	Partial duplication of the phalanges of the 3rd finger	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 3rd finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	UMLS:C4024142	hp.json	Partial duplication of middle finger bones	http://purl.obolibrary.org/obo/HP_0009961		
HP:0009964	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the 3rd finger	Partial or complete duplication of the third proximal phalanx of hand.	UMLS:C4021361	hp.json	Duplication of the proximal bone of the middle finger|Partial/complete duplication of the proximal phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009964		
HP:0007301	biolink:PhenotypicFeature	Oromotor apraxia	Oral-motor apraxia is the inability to volitionally sequence oral movements of the speech structure for nonspeech tasks in the absence of neuromuscular deficits such as paralysis or muscle weakness. Oral-motor apraxia is diagnosed when, despite intact sensory motor function an individual is unable to use these effector systems under voluntary control.	UMLS:C4021845	hp.json	Oral-motor apraxia	http://purl.obolibrary.org/obo/HP_0007301		
HP:0007302	biolink:PhenotypicFeature	Bipolar affective disorder		SNOMEDCT_US:13746004|UMLS:C0005586|MSH:D001714	hp.json	Bipolar disorder	http://purl.obolibrary.org/obo/HP_0007302		
HP:0009963	biolink:PhenotypicFeature	Duplication of the middle phalanx of the 3rd finger	Partial or complete duplication of the middle phalanx of middle finger.	UMLS:C4021362	hp.json	Duplication of the middle bone of the middle finger|Partial/complete duplication of the middle phalanx of the 3rd finger	http://purl.obolibrary.org/obo/HP_0009963		
HP:0009960	biolink:PhenotypicFeature	Complete duplication of the phalanges of the 3rd finger	A complete duplication affecting one or more of the phalanges of the 3rd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.	UMLS:C4024143	hp.json	Complete duplication of middle finger bones	http://purl.obolibrary.org/obo/HP_0009960		
HP:0010951	biolink:PhenotypicFeature	Abnormal third ventricle morphology	An abnormality of the third ventricle.	UMLS:C4023629	hp.json	Abnormality of the third ventricle	http://purl.obolibrary.org/obo/HP_0010951		
HP:0010950	biolink:PhenotypicFeature	Abnormal fourth ventricle morphology	An abnormality of the fourth ventricle.	UMLS:C4023630	hp.json	Abnormality of the fourth ventricle	http://purl.obolibrary.org/obo/HP_0010950		
HP:0010959	biolink:PhenotypicFeature	Congenital pulmonary airway malformation	Congenital pulmonary airway malformation (CPAM) - previously known as congenital cystic adenomatoid malformation (CCAM) - is a relatively rare developmental malformation of the lower respiratory tract. It is a hamartomatous, dysplastic developmental abnormality of the lung characterized by abnormal airway patterning during lung branching morphogenesis and is formed by abnormal branching of the immature bronchioles.	SNOMEDCT_US:111318005|MSH:D015615|UMLS:C0010668	hp.json	Cystic adenomatoid lung disease|Congenital cystic adenomatoid malformation of the lung|CCAM|Congenital cystic disease of the lung	http://purl.obolibrary.org/obo/HP_0010959		
HP:0010958	biolink:PhenotypicFeature	Bilateral renal agenesis	A bilateral form of agenesis of the kidney.	SNOMEDCT_US:41962002|UMLS:C1609433|MSH:C536482	hp.json		http://purl.obolibrary.org/obo/HP_0010958		
HP:0010957	biolink:PhenotypicFeature	Congenital posterior urethral valve	A developmental defect resulting in an obstructing membrane in the posterior male urethra.	UMLS:C0238506|SNOMEDCT_US:253900005	hp.json	Posterior urethral valves|Posterior urethral valve	http://purl.obolibrary.org/obo/HP_0010957		
HP:0010956	biolink:PhenotypicFeature	Fetal megacystis	Fetal megacystis is an abnormally enlarged bladder identified at any gestational age.	MSH:C536139|UMLS:C2931117	hp.json	Foetal megacystis	http://purl.obolibrary.org/obo/HP_0010956		
HP:0010955	biolink:PhenotypicFeature	Dilatation of the bladder	The presence of a dilated urinary bladder.	UMLS:C0549253	hp.json		http://purl.obolibrary.org/obo/HP_0010955		
HP:0009977	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the 4th finger	Partial or complete duplication of the fourth proximal phalanx of hand.	UMLS:C4021356	hp.json	Partial/complete duplication of the proximal phalanx of the 4th finger|Duplication of the proximal bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009977		
HP:0007314	biolink:PhenotypicFeature	obsolete White matter neuronal heterotopia			hp.json		http://purl.obolibrary.org/obo/HP_0007314		
HP:0009976	biolink:PhenotypicFeature	Duplication of the middle phalanx of the 4th finger	Partial or complete duplication of the middle phalanx of ring finger.	UMLS:C4021357	hp.json	Partial/complete duplication of the middle phalanx of the 4th finger|Partial/complete duplication of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009976		
HP:0010954	biolink:PhenotypicFeature	Hypoplastic right heart	Underdevelopment of the right-sided structures of the heart.	SNOMEDCT_US:268180007|UMLS:C0344963|SNOMEDCT_US:39589002|UMLS:C0265856	hp.json	Underdeveloped right heart|Hypoplastic right heart syndrome	http://purl.obolibrary.org/obo/HP_0010954		
HP:0009979	biolink:PhenotypicFeature	Complete duplication of the middle phalanx of the 4th finger	Complete duplication of the middle phalanx of ring finger.	UMLS:C4024132	hp.json	Complete duplication of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009979		
HP:0010953	biolink:PhenotypicFeature	Noncommunicating hydrocephalus	A form of hydrocephalus in which the flow of cerebrospinal fluid (CSF) within the cerebral ventricular system or in the outlets of the CSF to the arachnoid space is obstructed.	SNOMEDCT_US:82346000|SNOMEDCT_US:230746009|UMLS:C0549423|MSH:D006849	hp.json		http://purl.obolibrary.org/obo/HP_0010953		
HP:0007316	biolink:PhenotypicFeature	obsolete Involuntary writhing movements			hp.json		http://purl.obolibrary.org/obo/HP_0007316		
HP:0010952	biolink:PhenotypicFeature	Mild fetal ventriculomegaly	A kind of ventriculomegaly occurring in the fetal period and usually diagnosed by prenatal ultrasound. Cerebral ventriculomegaly is defined by atrial measurements 10 mm or more. Mild ventriculomegaly (MVM) is defined as measurements between 10 and 15 mm. Measurements are obtained from an axial plane at the level of the thalamic nuclei just below the standard image to measure the BPD (PMID:16100637).	UMLS:C4023628	hp.json	Mild foetal ventriculomegaly	http://purl.obolibrary.org/obo/HP_0010952		
HP:0009978	biolink:PhenotypicFeature	Complete duplication of the distal phalanx of the 4th finger	Complete duplication of the distal phalanx of ring finger.	UMLS:C4024133	hp.json	Complete duplication of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009978		
HP:0009973	biolink:PhenotypicFeature	Complete duplication of the phalanges of the 4th finger	A complete duplication affecting one or more of the phalanges of the 4th finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.	UMLS:C4024135	hp.json	Complete duplication of the bones of the ring finger	http://purl.obolibrary.org/obo/HP_0009973		
HP:0009972	biolink:PhenotypicFeature	Duplication of phalanx of 4th finger	This term applies if one or more of the phalanges of the 4th finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.	UMLS:C4021359	hp.json	Partial/complete duplication of phalanges of the 4th finger|Duplication of bones of the ring finger	http://purl.obolibrary.org/obo/HP_0009972		
HP:0007311	biolink:PhenotypicFeature	Short stepped shuffling gait		UMLS:C3805715	hp.json	Short stepped shuffling walk	http://purl.obolibrary.org/obo/HP_0007311		
HP:0009975	biolink:PhenotypicFeature	Duplication of the distal phalanx of the 4th finger	Partial or complete duplication of the distal phalanx of ring finger.	UMLS:C4021358	hp.json	Partial/complete duplication of the distal phalanx of the 4th finger|Partial/complete duplication of the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009975		
HP:0009974	biolink:PhenotypicFeature	Partial duplication of the phalanges of the 4th finger	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 4th finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	UMLS:C4024134	hp.json	Partial duplication of the bones of the ring finger	http://purl.obolibrary.org/obo/HP_0009974		
HP:0007313	biolink:PhenotypicFeature	Cerebral degeneration		SNOMEDCT_US:52522001|UMLS:C0154671|SNOMEDCT_US:418143002	hp.json	Neuroaxonal degeneration in the brain	http://purl.obolibrary.org/obo/HP_0007313		
HP:0009971	biolink:PhenotypicFeature	Polydactyly affecting the 4th finger		UMLS:C4024136	hp.json	Extra ring finger	http://purl.obolibrary.org/obo/HP_0009971		
HP:0009970	biolink:PhenotypicFeature	Partial duplication of the proximal phalanx of the 3rd finger	Partial duplication of the third proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4024137	hp.json	Partial duplication of the proximal bone of the middle finger	http://purl.obolibrary.org/obo/HP_0009970		
GO:0001873	biolink:MolecularActivity	polysaccharide immune receptor activity	Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.		hp.json	polysaccharide receptor activity	http://purl.obolibrary.org/obo/GO_0001873		
HP:0010940	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the nasal bone	Absence or underdevelopment of the nasal bone.	UMLS:C4023636	hp.json		http://purl.obolibrary.org/obo/HP_0010940		
HP:0010948	biolink:PhenotypicFeature	Abnormal fetal cardiovascular morphology	A structural abnormality of the fetal circulation system. Terms in this subhierarchy are restricted to findings that can only be observed in the prenatal period. Other HPO terms can also be used to describe fetal phenotypes.	UMLS:C4021210	hp.json	Abnormality of the fetal cardiovascular system|Abnormality of the foetal circulation system|Abnormality of the foetal cardiovascular system|Abnormality of the fetal circulation system	http://purl.obolibrary.org/obo/HP_0010948		
HP:0009948	biolink:PhenotypicFeature	Duplication of the distal phalanx of the 2nd finger	Partial or complete duplication of the distal phalanx of index finger.	UMLS:C4021367	hp.json	Partial/complete duplication of the distal phalanx of the 2nd finger|Partial/complete duplication of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009948		
HP:0009947	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the 2nd finger	Partial or complete duplication of the second proximal phalanx of hand.	UMLS:C4021368	hp.json	Partial/complete duplication of the proximal phalanx of the 2nd finger|Duplication of the proximal bone of the index finger	http://purl.obolibrary.org/obo/HP_0009947		
HP:0010947	biolink:PhenotypicFeature	Abnormality of ductus venosus blood flow	A first-trimester prenatal ultrasound finding of abnormal blood flow in the ductus venosus.	UMLS:C4023632	hp.json		http://purl.obolibrary.org/obo/HP_0010947		
HP:0010946	biolink:PhenotypicFeature	Dilatation of the renal pelvis	The presence of dilatation of the renal pelvis.	UMLS:C1868864	hp.json		http://purl.obolibrary.org/obo/HP_0010946		
HP:0009949	biolink:PhenotypicFeature	Duplication of the middle phalanx of the 2nd finger	Partial or complete duplication of the middle phalanx of index finger.	UMLS:C4021366	hp.json	Partial/complete duplication of the middle bone of the index finger|Partial/complete duplication of the middle phalanx of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009949		
HP:0010945	biolink:PhenotypicFeature	Fetal pyelectasis	Mild pyelectasis is defined as a hypoechoic spherical or elliptical space within the renal pelvis that measures at least 5mm and not more than 10 mm. The measurement is taken on a transverse section through the fetal renal pelvis using the maximum anterior-to-posterior measurement.	UMLS:C2317073|SNOMEDCT_US:430035004|MSH:D058536	hp.json	Mild fetal hydronephrosis|Foetal renal pelvic dilatation|Fetal renal pelvic dilatation|Foetal pyelectasis|Mild foetal hydronephrosis	http://purl.obolibrary.org/obo/HP_0010945		
HP:0010944	biolink:PhenotypicFeature	Abnormal renal pelvis morphology	An abnormality of the renal pelvis.	UMLS:C4023633	hp.json	Abnormality of the renal pelvis	http://purl.obolibrary.org/obo/HP_0010944		
HP:0009944	biolink:PhenotypicFeature	Partial duplication of thumb phalanx	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the thumb. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	UMLS:C4082168	hp.json	Notching of thumb phalanges|Partial duplication of the thumb bones|Partial duplication of the phalanges of the thumb|Bifid thumb	http://purl.obolibrary.org/obo/HP_0009944		
HP:0009943	biolink:PhenotypicFeature	Complete duplication of thumb phalanx	A complete duplication affecting one or more of the phalanges of the thumb. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.	UMLS:C3554724	hp.json	Complete duplication of the phalanges of the thumb|Digitalization of thumbs|Digitalization of thumb|Complete duplication of thumb bones	http://purl.obolibrary.org/obo/HP_0009943		
HP:0010943	biolink:PhenotypicFeature	Echogenic fetal bowel	Echogenic bowel is defined as fetal bowel with homogenous areas of echogenicity that are equal to or greater than that of surrounding bone.	UMLS:C2936423|MSH:D058535	hp.json	Echogenic foetal bowel|Echogenic bowel	http://purl.obolibrary.org/obo/HP_0010943		
HP:0009946	biolink:PhenotypicFeature	Polydactyly affecting the 2nd finger		UMLS:C4024152	hp.json	Extra index finger	http://purl.obolibrary.org/obo/HP_0009946		
HP:0010942	biolink:PhenotypicFeature	Echogenic intracardiac focus	A finding of a focus of increased echogenicity upon prenatal ultrasound examination of the fetus. The foci may be present in one or both ventricles. Echogenic intracardiac focus (EICF) is defined as a focus of echogenicity comparable to bone, in the region of the papillary muscle in either or both ventricles of the fetal heart.	UMLS:C4023634	hp.json		http://purl.obolibrary.org/obo/HP_0010942		
HP:0010941	biolink:PhenotypicFeature	Aplasia of the nasal bone	Absence of the nasal bone.	MSH:C562753|SNOMEDCT_US:91900007|UMLS:C4023635|UMLS:C0339851|UMLS:C0339850	hp.json	Missing nasal bone|Lack of development of the nasal bone|Absence of the nasal bone|Agenesis of the nasal bone|Failure of development of the nasal bone	http://purl.obolibrary.org/obo/HP_0010941		
HP:0009945	biolink:PhenotypicFeature	Duplication of phalanx of 2nd finger	This term applies if one or more of the phalanges of the 2nd finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.	UMLS:C4021369	hp.json	Duplication of the bones of index finger|Partial/complete duplication of phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0009945		
HP:0009940	biolink:PhenotypicFeature	Asymmetry of the mandible	Lack of symmetry between the left and right mandible.	UMLS:C4082201|UMLS:C0399518|SNOMEDCT_US:235082006	hp.json	Deviation of mandible|Tilted lower jaw|Crooked lower jaw|Canted mandible|Uneven mandible|Asymmetry of lower jaw|Lower jaw shifted to one side|Tilted mandible|Canted lower jaw|Uneven lower jaw|Deviation of the lower jaw|Deviation of the mandible|Deviation of lower jaw	http://purl.obolibrary.org/obo/HP_0009940		hposlim_core
HP:0009942	biolink:PhenotypicFeature	Duplication of thumb phalanx	Complete or partial duplication of the phalanges of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones (bifid), two separate bones appearing side to side, or completely duplicated phalanges (proximal and distal phalanx of the thumb and/or 1st metacarpal). In contrast to the phalanges of the digits 2-5 (proximal, middle and distal), the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4021370	hp.json	Duplicated thumbs|Duplication of phalanx of thumb|Complete/partial duplication of phalanges of the thumb|Duplicated thumb	http://purl.obolibrary.org/obo/HP_0009942		
HP:0009941	biolink:PhenotypicFeature	Asymmetry of the mouth	The presence of an asymmetric mouth.	UMLS:C4024153	hp.json	Asymmetry of oral cavity|Canted mouth|Uneven mouth|Tilted mouth|Crooked mouth|Asymmetry of the mouth	http://purl.obolibrary.org/obo/HP_0009941		hposlim_core
GO:0001878	biolink:BiologicalProcess	response to yeast	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.		hp.json		http://purl.obolibrary.org/obo/GO_0001878		
HP:0010949	biolink:PhenotypicFeature	Abnormality of umbilical vein blood flow	A first-trimester prenatal ultrasound finding of abnormal blood flow in the umbilical vein.	UMLS:C4023631	hp.json		http://purl.obolibrary.org/obo/HP_0010949		
GO:0098796	biolink:CellularComponent	membrane protein complex	Any protein complex that is part of a membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0098796		goslim_metagenomics
GO:0001885	biolink:BiologicalProcess	endothelial cell development	The progression of an endothelial cell over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0001885		
GO:0098797	biolink:CellularComponent	plasma membrane protein complex	Any protein complex that is part of the plasma membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0098797		
GO:0001886	biolink:BiologicalProcess	endothelial cell morphogenesis	The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.		hp.json		http://purl.obolibrary.org/obo/GO_0001886		
GO:0098794	biolink:CellularComponent	postsynapse	The part of a synapse that is part of the post-synaptic cell.		hp.json		http://purl.obolibrary.org/obo/GO_0098794		goslim_synapse
GO:0098793	biolink:CellularComponent	presynapse	The part of a synapse that is part of the presynaptic cell.		hp.json	presynaptic terminal	http://purl.obolibrary.org/obo/GO_0098793		goslim_synapse
HP:0032300	biolink:PhenotypicFeature	Increased circulating IgG4 level	An abnormally increased concentration of the IgG4 subtype in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032300		
HP:0032301	biolink:PhenotypicFeature	Genital warts	Warts affecting the skin in the genital area (peniile shaft, scrotum, vagina, or labia majora). Warts can be small, beginning as a pinhead-size swelling that may become larger and take on a pdenuculated appearance. Warts can spread and coalesce into large masses in the genital or anal area. Their color is variable but tends to be skin colored or darker, and they may occasionally bleed. Warts may cause itching, redness, or discomfort. An outbreak of genital warts may also cause psychological distress.		hp.json		http://purl.obolibrary.org/obo/HP_0032301		
HP:0032302	biolink:PhenotypicFeature	Kappa Bence Jones proteinuria	The presence of free monoclonal kappa immunoglobulin light chains in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032302		
HP:0010937	biolink:PhenotypicFeature	Abnormal nasal skeleton morphology	An abnormality of the nasal skeleton.	UMLS:C4280361|UMLS:C4023639	hp.json	Distortion of the nasal skeleton|Distortion of the bones of the nose|Deformity of the nasal skeleton|Malformation of the nasal skeleton|Abnormality of the nasal skeleton|Anomaly of the nasal skeleton|Malformation of the bones of the nose|Deformity of the bones of the nose	http://purl.obolibrary.org/obo/HP_0010937		
HP:0009959	biolink:PhenotypicFeature	Duplication of phalanx of 3rd finger	This term applies if one or more of the phalanges of the 3rd finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.	UMLS:C4021364	hp.json	Partial/complete duplication of phalanges of the 3rd finger|Duplication of middle finger bone	http://purl.obolibrary.org/obo/HP_0009959		
HP:0010936	biolink:PhenotypicFeature	Abnormality of the lower urinary tract	An abnormality of the lower urinary tract.	UMLS:C4023640	hp.json		http://purl.obolibrary.org/obo/HP_0010936		
HP:0009958	biolink:PhenotypicFeature	Polydactyly affecting the 3rd finger		UMLS:C4024144	hp.json	Extra middle finger	http://purl.obolibrary.org/obo/HP_0009958		
HP:0032308	biolink:PhenotypicFeature	Increased circulating procalcitonin concentration	An elevated concentration of procalcitonin in the blood circulation.		hp.json	Increased circulating procalcitonin level	http://purl.obolibrary.org/obo/HP_0032308		
HP:0032309	biolink:PhenotypicFeature	Abnormal granulocyte count	Any deviation from the normal cell count per volume of granulocytes in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032309		
HP:0010935	biolink:PhenotypicFeature	Abnormality of the upper urinary tract	An abnormality of the upper urinary tract.	UMLS:C4023641	hp.json	Abnormality of the upper urinary tract	http://purl.obolibrary.org/obo/HP_0010935		
HP:0010934	biolink:PhenotypicFeature	Xanthinuria	An increased concentration of xanthine in the urine.	UMLS:C0220988|SNOMEDCT_US:54627004|SNOMEDCT_US:190919008	hp.json	Increased urinary xanthine	http://purl.obolibrary.org/obo/HP_0010934		
HP:0032303	biolink:PhenotypicFeature	Lambda Bence Jones proteinuria	The presence of free monoclonal lambda immunoglobulin light chains in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032303		
HP:0010933	biolink:PhenotypicFeature	Hyperxanthinemia	An increased level of xanthine in the blood circulation.	UMLS:C4023642	hp.json	Increased circulating xanthine concentration	http://purl.obolibrary.org/obo/HP_0010933		
HP:0009955	biolink:PhenotypicFeature	Partial duplication of the proximal phalanx of the 2nd finger	Partial duplication of the second proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4024147	hp.json	Partial duplication of the proximal bones of the index finger	http://purl.obolibrary.org/obo/HP_0009955		
HP:0010932	biolink:PhenotypicFeature	Abnormal circulating nucleobase concentration	An abnormality of a nucleobase metabolic process.	UMLS:C4020762|UMLS:C4023643	hp.json	Abnormal nucleoside levels	http://purl.obolibrary.org/obo/HP_0010932		
HP:0032304	biolink:PhenotypicFeature	Abnormal mannose-binding protein level	Any deviation from the normal concentration of mannose-binding protein in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032304		
HP:0009954	biolink:PhenotypicFeature	Complete duplication of the proximal phalanx of the 2nd finger	Complete duplication of the second proximal phalanx of hand.	UMLS:C4024148	hp.json	Complete duplication of the proximal bone of the index finger	http://purl.obolibrary.org/obo/HP_0009954		
HP:0010931	biolink:PhenotypicFeature	Abnormal blood sodium concentration	An abnormal concentration of sodium.	UMLS:C4023644	hp.json	Abnormal circulating Na concentration|Abnormal blood Na+ levels|Abnormality of sodium homeostasis	http://purl.obolibrary.org/obo/HP_0010931		
HP:0032305	biolink:PhenotypicFeature	Decreased mannose-binding protein level	An abnormal reduction below the normal concentration of mannose-binding protein in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032305		
HP:0009957	biolink:PhenotypicFeature	Complete duplication of the phalanges of the 2nd finger	A complete duplication affecting one or more of the phalanges of the 2nd finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, is a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.	UMLS:C4024145	hp.json	Complete duplication of the bones of the index finger	http://purl.obolibrary.org/obo/HP_0009957		
HP:0032306	biolink:PhenotypicFeature	Increased mannose-binding protein level	An abnormal elevation above the normal concentration of mannose-binding protein in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032306		
HP:0009956	biolink:PhenotypicFeature	Partial duplication of the phalanges of the 2nd finger	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 2nd finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	UMLS:C4024146	hp.json	Partial duplication of the bones of the index finger	http://purl.obolibrary.org/obo/HP_0009956		
HP:0010930	biolink:PhenotypicFeature	Abnormal blood monovalent inorganic cation concentration	An abnormality of monovalent inorganic cation homeostasis.	UMLS:C4023645	hp.json	Abnormality of monovalent inorganic cation homeostasis	http://purl.obolibrary.org/obo/HP_0010930		
HP:0009951	biolink:PhenotypicFeature	Partial duplication of the distal phalanx of the 2nd finger	Partial duplication of the distal phalanx of index finger, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4021365	hp.json	Bifid terminal phalanx of the 2nd finger|Partial duplication of the outermost bone of the 2nd finger|Notched outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009951		
HP:0009950	biolink:PhenotypicFeature	Complete duplication of the distal phalanx of the 2nd finger	Complete duplication of the distal phalanx of index finger.	UMLS:C4024151	hp.json	Complete duplication of the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0009950		
HP:0009953	biolink:PhenotypicFeature	Partial duplication of the middle phalanx of the 2nd finger	Partial duplication of the middle phalanx of index finger, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4024149	hp.json	Partial duplication of the middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0009953		
HP:0009952	biolink:PhenotypicFeature	Complete duplication of the middle phalanx of the 2nd finger	Complete duplication of the middle phalanx of index finger.	UMLS:C4024150	hp.json	Complete duplication of the middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0009952		
CHEBI:50584	biolink:ChemicalSubstance	alkyl alcohol	An aliphatic alcohol in which the aliphatic alkane chain is substituted by a hydroxy group at unspecified position.		hp.json	alkyl alcohols|hydroxyalkanes|hydroxyalkane	http://purl.obolibrary.org/obo/CHEBI_50584		3_STAR
HP:0010939	biolink:PhenotypicFeature	Abnormal nasal bone morphology	An abnormality of the nasal bone, comprising the left nasal bone and the right nasal bone.	UMLS:C4023637	hp.json	Deformity of the nasal bones|Malformation of the nasal bones|Abnormality of the nasal bone|Anomaly of the nasal bones	http://purl.obolibrary.org/obo/HP_0010939		
GO:0098798	biolink:CellularComponent	mitochondrial protein-containing complex	A protein complex that is part of a mitochondrion.		hp.json	mitochondrial protein complex	http://purl.obolibrary.org/obo/GO_0098798		gocheck_do_not_manually_annotate
HP:0010938	biolink:PhenotypicFeature	Abnormality of the external nose	An abnormality of the external nose.	UMLS:C2164724|UMLS:C4280360|UMLS:C4023638	hp.json	Anomaly of the external nose|Deformity of the external nose|Malformation of the external nose|Abnormality of the external nose	http://purl.obolibrary.org/obo/HP_0010938		
HP:0007348	biolink:PhenotypicFeature	Hypoplasia of the pyramidal tract		UMLS:C1850871	hp.json		http://purl.obolibrary.org/obo/HP_0007348		
HP:0007343	biolink:PhenotypicFeature	Abnormal morphology of the limbic system	Any structural anomaly of the limbic system, a set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex].	UMLS:C1863392	hp.json	Limbic malformation	http://purl.obolibrary.org/obo/HP_0007343		
HP:0007344	biolink:PhenotypicFeature	Atrophy/Degeneration involving the spinal cord		UMLS:C1843858	hp.json	Atrophic and degenerative changes in the spinal cord	http://purl.obolibrary.org/obo/HP_0007344		
HP:0007346	biolink:PhenotypicFeature	Subcortical white matter calcifications		UMLS:C1851430	hp.json		http://purl.obolibrary.org/obo/HP_0007346		
HP:0007340	biolink:PhenotypicFeature	Lower limb muscle weakness	Weakness of the muscles of the legs.	UMLS:C0427068|SNOMEDCT_US:249945007|UMLS:C1836296	hp.json	Lower limb muscle weakness|Lower limb weakness|Lower extremity weakness|Muscle weakness in lower limbs|Leg weakness	http://purl.obolibrary.org/obo/HP_0007340		
HP:0007341	biolink:PhenotypicFeature	Diffuse swelling of cerebral white matter		UMLS:C1858855	hp.json		http://purl.obolibrary.org/obo/HP_0007341		
HP:0007360	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the cerebellum		UMLS:C3279222	hp.json	Absent/small cerebellum|Absent/underdeveloped cerebellum|Cerebellar hypoplasia/atrophy|Atrophy/Hypoplasia of the cerebellum|Atrophy/Degeneration affecting the cerebellum	http://purl.obolibrary.org/obo/HP_0007360		
HP:0010995	biolink:PhenotypicFeature	Abnormal circulating dicarboxylic acid concentration	Any deviation from the normal concentration of a dicarboxylic acid in the blood circulation.	UMLS:C4023606	hp.json		http://purl.obolibrary.org/obo/HP_0010995		
HP:0010994	biolink:PhenotypicFeature	Abnormal corpus striatum morphology	Abnormality of the striatum, which is the largest nucleus of the basal ganglia, comprising the caudate, putamen and ventral striatum, including the nucleus accumbens.	UMLS:C4023607	hp.json	Abnormality of the neostriatum|Abnormality of the striatum|Abnormality of the striate nucleus	http://purl.obolibrary.org/obo/HP_0010994		
HP:0010993	biolink:PhenotypicFeature	Abnormal cerebral subcortex morphology	An abnormality of the cerebral subcortex.	UMLS:C4021207	hp.json	Abnormality of the cerebral medulla|Abnormality of the cerebral subcortex	http://purl.obolibrary.org/obo/HP_0010993		
HP:0010992	biolink:PhenotypicFeature	Stress urinary incontinence	Involuntary urine leakage synchronous with exertion, or actions such as sneezing, or coughing.	UMLS:C0042025|SNOMEDCT_US:22220005|MSH:D014550	hp.json		http://purl.obolibrary.org/obo/HP_0010992		
HP:0010991	biolink:PhenotypicFeature	Abnormal morphology of the abdominal musculature	An abnormality of the abdominal musculature.	UMLS:C4023608	hp.json	Abnormality of the abdominal musculature	http://purl.obolibrary.org/obo/HP_0010991		
HP:0010990	biolink:PhenotypicFeature	Abnormality of the common coagulation pathway	An abnormality of blood coagulation, common pathway.	UMLS:C4023609	hp.json		http://purl.obolibrary.org/obo/HP_0010990		
UBERON:0012504	biolink:AnatomicalEntity	adventitia of esophagus	An adventitia that is part of a esophagus.	SCTID:85950006|FMA:63006	hp.json	esophageal adventitia|tunica adventitia oesophageae|tunica adventitia (esophagus)|adventitia of oesophagus|esophagus adventitia|adventitious layer of esophagus	http://purl.obolibrary.org/obo/UBERON_0012504		
HP:0010999	biolink:PhenotypicFeature	Aplasia of the optic tract		UMLS:C4023603	hp.json	Absent optic tract	http://purl.obolibrary.org/obo/HP_0010999		
HP:0007359	biolink:PhenotypicFeature	Focal-onset seizure	A focal-onset seizure is a type of seizure originating within networks limited to one hemisphere. They may be discretely localized or more widely distributed, and may originate in subcortical structures.	MSH:D012640|SNOMEDCT_US:29753000|UMLS:C0751495	hp.json	Focal onset seizure|Seizure affecting one half of brain|Focal seizures|Focal seizure|Partial seizure|Focal-onset seizures|Partial seizures	http://purl.obolibrary.org/obo/HP_0007359		
HP:0010998	biolink:PhenotypicFeature	Increased susceptibility to spontaneous sister chromatid exchange	An increase in the number of spontaneous sister chromatid exchanges observed in cell culture of lymphocytes or other cells.	UMLS:C4023604	hp.json		http://purl.obolibrary.org/obo/HP_0010998		
HP:0010997	biolink:PhenotypicFeature	Chromosomal breakage induced by ionizing radiation	Increased amount of chromosomal breaks in cultured blood lymphocytes or other cells induced by treatment with ionizing radiation.	UMLS:C4021206	hp.json	Chromosomal breakage induced by ionising radiation|Radiation-induced chromosome instability|Increased cellular radiosensitivity	http://purl.obolibrary.org/obo/HP_0010997		
HP:0010996	biolink:PhenotypicFeature	Abnormal circulating monocarboxylic acid concentration	Any deviation from the normal concentration of a monocarboxylic acid in the blood circulation.	UMLS:C4023605	hp.json		http://purl.obolibrary.org/obo/HP_0010996		
HP:0007354	biolink:PhenotypicFeature	Amyotrophic lateral sclerosis		MSH:D000690|SNOMEDCT_US:86044005|UMLS:C0002736	hp.json	Lou Gehrig's disease	http://purl.obolibrary.org/obo/HP_0007354		
HP:0007350	biolink:PhenotypicFeature	Hyperreflexia in upper limbs		UMLS:C1843175	hp.json		http://purl.obolibrary.org/obo/HP_0007350		
HP:0007351	biolink:PhenotypicFeature	Upper limb postural tremor	A type of tremors that is triggered by holding an arm in a fixed position.	UMLS:C1867138	hp.json	Postural tremor of arms	http://purl.obolibrary.org/obo/HP_0007351		
HP:0007352	biolink:PhenotypicFeature	Cerebellar calcifications		UMLS:C1851431	hp.json		http://purl.obolibrary.org/obo/HP_0007352		
GO:0001831	biolink:BiologicalProcess	trophectodermal cellular morphogenesis	The morphogenesis of trophectoderm cells.		hp.json	trophectoderm cellular morphogenesis	http://purl.obolibrary.org/obo/GO_0001831		
GO:0001832	biolink:BiologicalProcess	blastocyst growth	An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0001832		
HP:0010984	biolink:PhenotypicFeature	Digenic inheritance	A type of multifactorial inheritance governed by the simultaneous action of two gene loci.	UMLS:C4023614	hp.json		http://purl.obolibrary.org/obo/HP_0010984		
HP:0010983	biolink:PhenotypicFeature	Oligogenic inheritance	A type of multifactorial inheritance governed by the simultaneous action of a few gene loci. It is recommended this term be used for traits governed by three loci, although it is noted that usage of this term in the literature is not uniform.	MSH:D020412|UMLS:C1136026	hp.json		http://purl.obolibrary.org/obo/HP_0010983		
HP:0010982	biolink:PhenotypicFeature	Polygenic inheritance	A type of multifactorial inheritance governed by the simultaneous action of many (more than three) gene loci.	UMLS:C1148552|MSH:D020412	hp.json		http://purl.obolibrary.org/obo/HP_0010982		
HP:0010981	biolink:PhenotypicFeature	Hypolipoproteinemia	An abnormal decrease in the level of lipoprotein cholesterol in the blood.	SNOMEDCT_US:267436001|UMLS:C0020623|MSH:D007009|SNOMEDCT_US:363140000	hp.json	Lack of fat in blood	http://purl.obolibrary.org/obo/HP_0010981		
HP:0010980	biolink:PhenotypicFeature	Hyperlipoproteinemia	An abnormal increase in the level of lipoprotein cholesterol in the blood.	UMLS:C0020476|MSH:D006951|SNOMEDCT_US:3744001	hp.json		http://purl.obolibrary.org/obo/HP_0010980		
CHEBI:62501	biolink:ChemicalSubstance	folate(2-)	The dicarboxylic acid dianion formed from folic acid by loss of a proton from each of the two carboxy groups in the glutamic acid moiety.	MetaCyc:CPD-12826|PMCID:PMC8181341|PMID:34051149	hp.json	folate|pteroyl-L-glutamate|pteroyl-L-monoglutamate|N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamate(2-)|pteroylglutamate|folate	http://purl.obolibrary.org/obo/CHEBI_62501		3_STAR
CHEBI:37578	biolink:ChemicalSubstance	halide	Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements.	Wikipedia:Halide	hp.json	halides	http://purl.obolibrary.org/obo/CHEBI_37578		3_STAR
CHEBI:37577	biolink:ChemicalSubstance	heteroatomic molecular entity	A molecular entity consisting of two or more chemical elements.		hp.json	heteroatomic molecular entities|chemical compound	http://purl.obolibrary.org/obo/CHEBI_37577		3_STAR
HP:0010989	biolink:PhenotypicFeature	Abnormality of the intrinsic pathway	An abnormality of the intrinsic pathway (also known as the contact activation pathway) of the coagulation cascade.	UMLS:C4023610	hp.json		http://purl.obolibrary.org/obo/HP_0010989		
HP:0007325	biolink:PhenotypicFeature	Generalized dystonia	A type of dystonia that affects all or most of the body.	SNOMEDCT_US:425492002|UMLS:C1848954	hp.json	Generalised dystonia	http://purl.obolibrary.org/obo/HP_0007325		
HP:0009988	biolink:PhenotypicFeature	Duplication of the distal phalanx of the 5th finger	Partial or complete duplication of the distal phalanx of little finger.	UMLS:C4021353	hp.json	Duplication of the outermost little finger bone|Duplication of the outermost pinky finger bone|Partial/complete duplication of the distal phalanx of the 5th finger|Duplication of the outermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009988		
HP:0010988	biolink:PhenotypicFeature	Abnormality of the extrinsic pathway	An abnormality of the extrinsic pathway (also known as the tissue factor pathway) of the coagulation cascade.	UMLS:C4023611	hp.json		http://purl.obolibrary.org/obo/HP_0010988		
HP:0009987	biolink:PhenotypicFeature	Partial duplication of the phalanges of the 5th finger	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 5th finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	UMLS:C4024127	hp.json	Partial duplication of the little finger bone|Partial duplication of the pinky finger bone|Partial duplication of the pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009987		
HP:0010987	biolink:PhenotypicFeature	Abnormal cellular immune system morphology	An abnormality of the morphology or counts of the cells that make up the immune system.	UMLS:C4023612	hp.json		http://purl.obolibrary.org/obo/HP_0010987		
HP:0007326	biolink:PhenotypicFeature	Progressive choreoathetosis		UMLS:C1860216	hp.json		http://purl.obolibrary.org/obo/HP_0007326		
HP:0007327	biolink:PhenotypicFeature	Mixed demyelinating and axonal polyneuropathy		UMLS:C4024907	hp.json		http://purl.obolibrary.org/obo/HP_0007327		
HP:0007328	biolink:PhenotypicFeature	Impaired pain sensation	Reduced ability to perceive painful stimuli.	UMLS:C1837522	hp.json	Decreased pain sensation|Decreased pinprick sensation|Impaired pain sensation	http://purl.obolibrary.org/obo/HP_0007328		
HP:0009989	biolink:PhenotypicFeature	Duplication of the middle phalanx of the 5th finger	Partial or complete duplication of the fifth middle phalanx of hand.	UMLS:C4021352	hp.json	Duplication of the middle pinky finger bone|Partial/complete duplication of the middle phalanx of the 5th finger|Duplication of the middle little finger bone|Duplication of the middle pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009989		
HP:0010985	biolink:PhenotypicFeature	obsolete Gonosomal inheritance			hp.json		http://purl.obolibrary.org/obo/HP_0010985		
GO:0001837	biolink:BiologicalProcess	epithelial to mesenchymal transition	A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.		hp.json	epithelial-mesenchymal transition|mesenchymal cell differentiation from epithelial cell|EMT	http://purl.obolibrary.org/obo/GO_0001837		
HP:0007321	biolink:PhenotypicFeature	Deep white matter hypodensities	Multiple areas of darker than expected signal on magnetic resonance imaging emanating from the deep cerebral white matter.	UMLS:C1856979	hp.json	Deep cerebral white matter hypodensities	http://purl.obolibrary.org/obo/HP_0007321		
GO:0001838	biolink:BiologicalProcess	embryonic epithelial tube formation	The morphogenesis of an embryonic epithelium into a tube-shaped structure.		hp.json		http://purl.obolibrary.org/obo/GO_0001838		
HP:0009983	biolink:PhenotypicFeature	Partial duplication of the proximal phalanx of the 4th finger	Partial duplication of the fourth proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4024129	hp.json	Partial duplication of the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009983		
GO:0001839	biolink:BiologicalProcess	neural plate morphogenesis	The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0001839		
HP:0009986	biolink:PhenotypicFeature	Complete duplication of the phalanges of the 5th finger	A complete duplication affecting one or more of the phalanges of the 5th finger. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.	UMLS:C4024128	hp.json	Complete duplication of the little finger bone|Complete duplication of the pinky finger bone|Complete duplication of the pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009986		
HP:0009985	biolink:PhenotypicFeature	Duplication of phalanx of 5th finger	This term applies if one or more of the phalanges of the 5th finger are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.	UMLS:C4021354	hp.json	Partial/complete duplication of phalanges of the 5th finger|Partial/complete duplication of pinky finger bone|Partial/complete duplication of little finger bone|Partial/complete duplication of pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009985		
HP:0009980	biolink:PhenotypicFeature	Complete duplication of the proximal phalanx of the 4th finger	Complete duplication of the fourth proximal phalanx of hand.	UMLS:C4024131	hp.json	Complete duplication of the proximal bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009980		
GO:0001833	biolink:BiologicalProcess	inner cell mass cell proliferation	The proliferation of cells in the inner cell mass.		hp.json		http://purl.obolibrary.org/obo/GO_0001833		
GO:0001834	biolink:BiologicalProcess	trophectodermal cell proliferation	The proliferation of cells in the trophectoderm.		hp.json	trophectoderm cell proliferation	http://purl.obolibrary.org/obo/GO_0001834		
HP:0009982	biolink:PhenotypicFeature	Partial duplication of the middle phalanx of the 4th finger	Partial duplication of the middle phalanx of ring finger, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4024130	hp.json	Partial duplication of the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0009982		
HP:0009981	biolink:PhenotypicFeature	Partial duplication of the distal phalanx of the 4th finger	Partial duplication of the distal phalanx of ring finger, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4021355	hp.json	Partial duplication of the outermost bone of the ring finger|Notched outermost bone of the ring finger|Bifid terminal phalanx of the 4th finger	http://purl.obolibrary.org/obo/HP_0009981		
GO:0001840	biolink:BiologicalProcess	neural plate development	The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0001840		
GO:0001841	biolink:BiologicalProcess	neural tube formation	The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.	Wikipedia:Neurulation	hp.json	neural tube morphogenesis|neurulation	http://purl.obolibrary.org/obo/GO_0001841		
GO:0001842	biolink:BiologicalProcess	neural fold formation	The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.		hp.json	neural groove formation	http://purl.obolibrary.org/obo/GO_0001842		
GO:0001843	biolink:BiologicalProcess	neural tube closure	The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.		hp.json		http://purl.obolibrary.org/obo/GO_0001843		
HP:0010972	biolink:PhenotypicFeature	Anemia of inadequate production	A kind of anemia characterized by inadequate production of erythrocytes.	UMLS:C0678199|SNOMEDCT_US:70730006|UMLS:C0392708	hp.json	Dyserythropoietic anaemia|Dyserythropoietic anemia|Anemia, dyserythropoietic|Ineffective erythropoiesis|Defective erythropoiesis|Anaemia of inadequate production	http://purl.obolibrary.org/obo/HP_0010972		
HP:0010971	biolink:PhenotypicFeature	Absence of Lutheran antigen on erythrocytes	Absence of the Lutheran antigen (a type I integral membrane glycoprotein) from the surface of red blood cells.	UMLS:C4023619	hp.json		http://purl.obolibrary.org/obo/HP_0010971		
HP:0010970	biolink:PhenotypicFeature	Blood group antigen abnormality	An abnormality of an erythrocyte cell surface molecule.	UMLS:C4023620	hp.json		http://purl.obolibrary.org/obo/HP_0010970		
HP:0010979	biolink:PhenotypicFeature	Abnormality of lipoprotein cholesterol concentration	An abnormal increase or decrease in the level of lipoprotein cholesterol in the blood.	UMLS:C4023615	hp.json	Abnormality of the level of lipoprotein cholesterol	http://purl.obolibrary.org/obo/HP_0010979		
HP:0010978	biolink:PhenotypicFeature	Abnormality of immune system physiology	A functional abnormality of the immune system.	UMLS:C4023616	hp.json		http://purl.obolibrary.org/obo/HP_0010978		
HP:0010977	biolink:PhenotypicFeature	Abnormal phagocytosis	An abnormal functioning of phagocytosis. Phagocytosis is an elegant but complex process for the ingestion and elimination of pathogens, but it is also important for the elimination of apoptotic cells and hence fundamental for tissue homeostasis. Phagocytosis can be divided into four main steps: (i) recognition of the target particle, (ii) signaling to activate the internalization machinery, (iii) phagosome formation, and (iv) phagolysosome maturation.	UMLS:C4023617	hp.json		http://purl.obolibrary.org/obo/HP_0010977		
HP:0009999	biolink:PhenotypicFeature	Partial duplication of the phalanx of hand	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	UMLS:C4024120	hp.json	Partial duplication of hand bones	http://purl.obolibrary.org/obo/HP_0009999		
HP:0009998	biolink:PhenotypicFeature	Complete duplication of phalanx of hand	A complete duplication affecting one or more of the phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, is a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.	UMLS:C4024121	hp.json	Complete duplication of hand bones	http://purl.obolibrary.org/obo/HP_0009998		
HP:0010976	biolink:PhenotypicFeature	B lymphocytopenia	An abnormal decrease from the normal count of B cells.	UMLS:C1855067	hp.json	Reduction in B cell number|B cell lymphopenia|B cell deficiency|Decreased B cell count|Low B cell count	http://purl.obolibrary.org/obo/HP_0010976		
HP:0007338	biolink:PhenotypicFeature	Hypermetric saccades	A saccade that overshoots the target with the dynamic saccade.	UMLS:C0423083|SNOMEDCT_US:246769000	hp.json		http://purl.obolibrary.org/obo/HP_0007338		
HP:0010975	biolink:PhenotypicFeature	Abnormal B cell count	A deviation from the normal count of B cells, i.e., the cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells.	UMLS:C4021208	hp.json	Abnormality of B cell numbers|Abnormal number of B cells|Abnormal numbers of B cells|Abnormality of B cell count	http://purl.obolibrary.org/obo/HP_0010975		
HP:0010974	biolink:PhenotypicFeature	Abnormal myeloid leukocyte morphology	An abnormality of myeloid leukocytes.	UMLS:C4023618	hp.json	Abnormality of myeloid leukocytes	http://purl.obolibrary.org/obo/HP_0010974		
HP:0009995	biolink:PhenotypicFeature	Partial duplication of the middle phalanx of the 5th finger	Partial duplication of the fifth middle phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4024123	hp.json	Partial duplication of the middle little finger bone|Partial duplication of the middle pinkie finger bone|Partial duplication of the middle pinky finger bone	http://purl.obolibrary.org/obo/HP_0009995		
HP:0007332	biolink:PhenotypicFeature	Focal hemifacial clonic seizure	Focal seizure characterized at onset by clonic movements affecting half of the face.	UMLS:C4024906	hp.json	Hemifacial seizures	http://purl.obolibrary.org/obo/HP_0007332		
HP:0007333	biolink:PhenotypicFeature	Hypoplasia of the frontal lobes	Underdevelopment of the frontal lobe of the cerebrum.	UMLS:C1849172	hp.json	Underdeveloped frontal lobe|Frontal lobe hypoplasia|Hypoplastic frontal lobes	http://purl.obolibrary.org/obo/HP_0007333		
HP:0009994	biolink:PhenotypicFeature	Partial duplication of the distal phalanx of the 5th finger	Partial duplication of the distal phalanx of little finger, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4021350	hp.json	Partial duplication of outermost pinky finger bone|Notched outermost pinky finger bone|Partial duplication of outermost little finger bone|Bifid terminal phalanx of the 5th finger|Partial duplication of outermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009994		
HP:0007334	biolink:PhenotypicFeature	Bilateral tonic-clonic seizure with focal onset	A bilateral tonic-clonic seizure with focal onset is a focal-onset seizure which progresses into a bilateral tonic-clonic phase.	UMLS:C0877017	hp.json	Focal to bilateral tonic-clonic seizure|Generalized tonic-clonic seizure with focal onset|Partial seizure with secondary generalisation|Secondary generalised tonic clonic seizures|Partial seizures with secondary generalization|Generalized tonic-clonic seizures with focal onset|Secondarily generalized tonic-clonic seizure|Secondarily generalised tonic-clonic seizures|Focal seizure with secondary generalization|Generalized tonic-clonic seizure with partial onset|Generalised tonic-clonic seizure with focal onset|Partial seizure with secondary generalization|Secondary generalized tonic-clonic seizures|Partial seizures with secondary generalisation|Secondarily generalised tonic-clonic seizure|Secondary generalized tonic clonic seizures|Generalised tonic-clonic seizure with partial onset|Focal seizure with secondary generalisation|Secondary generalised tonic-clonic seizures|Generalised tonic-clonic seizures with focal onset	http://purl.obolibrary.org/obo/HP_0007334		
HP:0009997	biolink:PhenotypicFeature	Duplication of phalanx of hand	This term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.	UMLS:C4021349	hp.json	Duplication of finger bones	http://purl.obolibrary.org/obo/HP_0009997		
GO:1990904	biolink:CellularComponent	ribonucleoprotein complex	A macromolecular complex that contains both RNA and protein molecules.	Wikipedia:Ribonucleoprotein	hp.json	RNA-protein complex|protein-RNA complex|extracellular ribonucleoprotein complex|RNP|intracellular ribonucleoprotein complex	http://purl.obolibrary.org/obo/GO_1990904		goslim_pir
HP:0009996	biolink:PhenotypicFeature	Partial duplication of the proximal phalanx of the 5th finger	Partial or complete duplication of the fifth proximal phalanx of hand, seen on x-rays as a broad and/or bifid phalanx.	UMLS:C4024122	hp.json	Partial duplication of the innermost pinky finger bone|Partial duplication of the innermost little finger bone|Partial duplication of the innermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009996		
HP:0007335	biolink:PhenotypicFeature	Recurrent encephalopathy	Recurrent episodes of brain dysfunction that may be triggered by factors such as metabolic disturbances or infections.	UMLS:C1850719	hp.json	Recurrent cerebellar and extrapyramidal encephalopathy	http://purl.obolibrary.org/obo/HP_0007335		
HP:0009991	biolink:PhenotypicFeature	Complete duplication of the distal phalanx of the 5th finger	Complete duplication of the distal phalanx of little finger.	UMLS:C4024126	hp.json	Complete duplication of the outermost little finger bone|Complete duplication of the outermost pinkie finger bone|Complete duplication of the outermost pinky finger bone	http://purl.obolibrary.org/obo/HP_0009991		
HP:0009990	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the 5th finger	Partial or complete duplication of the fifth proximal phalanx of hand.	UMLS:C4021351	hp.json	Duplication of the innermost pinky finger bone|Duplication of the innermost little finger bone|Partial/complete duplication of the proximal phalanx of the 5th finger|Duplication of the innermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009990		
HP:0009993	biolink:PhenotypicFeature	Complete duplication of the proximal phalanx of the 5th finger	Complete duplication of the fifth proximal phalanx of hand.	UMLS:C4024124	hp.json	Complete duplication of the innermost pinkie finger bone|Complete duplication of the innermost pinky finger bone|Complete duplication of the innermost little finger bone	http://purl.obolibrary.org/obo/HP_0009993		
HP:0007330	biolink:PhenotypicFeature	Frontal encephalocele		SNOMEDCT_US:253103006|UMLS:C0431289|MSH:D004677	hp.json		http://purl.obolibrary.org/obo/HP_0007330		
HP:0009992	biolink:PhenotypicFeature	Complete duplication of the middle phalanx of the 5th finger	Complete duplication of the fifth middle phalanx of hand.	UMLS:C4024125	hp.json	Complete duplication of the middle pinky finger bone|Complete duplication of the middle little finger bone|Complete duplication of the middle pinkie finger bone	http://purl.obolibrary.org/obo/HP_0009992		
CHEBI:191220	biolink:ChemicalSubstance	(2S)-methylsuccinate(2-)	The dicarboxylate anion of (S)-methylsuccinic acid; major species at pH 7.3.		hp.json	(2S)-methylsuccinate	http://purl.obolibrary.org/obo/CHEBI_191220		2_STAR
GO:0050789	biolink:BiologicalProcess	regulation of biological process	Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.		hp.json	regulation of physiological process	http://purl.obolibrary.org/obo/GO_0050789		goslim_candida|gocheck_do_not_annotate|goslim_pir|goslim_aspergillus
GO:1904951	biolink:BiologicalProcess	positive regulation of establishment of protein localization	Any process that activates or increases the frequency, rate or extent of establishment of protein localization.		hp.json	positive regulation of protein positioning|up-regulation of establishment of protein localization|upregulation of protein recruitment|upregulation of establishment of protein localisation|up regulation of establishment of protein localization|upregulation of protein positioning|activation of establishment of protein localization|up-regulation of protein recruitment|upregulation of establishment of protein localization|up-regulation of establishment of protein localisation|up regulation of protein recruitment|up-regulation of protein positioning|activation of protein recruitment|positive regulation of protein recruitment|up regulation of establishment of protein localisation|up regulation of protein positioning|activation of establishment of protein localisation|positive regulation of establishment of protein localisation|activation of protein positioning	http://purl.obolibrary.org/obo/GO_1904951		
GO:1904950	biolink:BiologicalProcess	negative regulation of establishment of protein localization	Any process that stops, prevents or reduces the frequency, rate or extent of establishment of protein localization.		hp.json	down-regulation of protein recruitment|negative regulation of protein recruitment|downregulation of establishment of protein localization|inhibition of establishment of protein localization|down-regulation of establishment of protein localisation|negative regulation of establishment of protein localisation|negative regulation of protein positioning|down-regulation of protein positioning|down regulation of protein recruitment|down regulation of establishment of protein localisation|down regulation of protein positioning|downregulation of protein recruitment|inhibition of protein recruitment|inhibition of establishment of protein localisation|downregulation of establishment of protein localisation|down-regulation of establishment of protein localization|inhibition of protein positioning|downregulation of protein positioning|down regulation of establishment of protein localization	http://purl.obolibrary.org/obo/GO_1904950		
GO:0035148	biolink:BiologicalProcess	tube formation	Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.		hp.json	tube lumen formation|lumen formation in an anatomical structure	http://purl.obolibrary.org/obo/GO_0035148		
GO:0098728	biolink:BiologicalProcess	germline stem cell asymmetric division	The self-renewing division of a germline stem cell, to produce a daughter stem cell and a daughter germ cell which will divide to form one or more gametes.		hp.json		http://purl.obolibrary.org/obo/GO_0098728		
GO:0098723	biolink:CellularComponent	skeletal muscle myofibril	A myofibril of a skeletal muscle fiber.		hp.json		http://purl.obolibrary.org/obo/GO_0098723		
GO:0098722	biolink:BiologicalProcess	asymmetric stem cell division	Division of a stem cell during which it retains its identity and buds off a daughter cell with a new identity.		hp.json		http://purl.obolibrary.org/obo/GO_0098722		
GO:0050796	biolink:NamedThing	regulation of insulin secretion			hp.json		http://purl.obolibrary.org/obo/GO_0050796		
GO:0050794	biolink:BiologicalProcess	regulation of cellular process	Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.		hp.json	regulation of cellular physiological process	http://purl.obolibrary.org/obo/GO_0050794		gocheck_do_not_annotate
GO:0050795	biolink:BiologicalProcess	regulation of behavior	Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.		hp.json	regulation of behaviour	http://purl.obolibrary.org/obo/GO_0050795		
GO:0050793	biolink:BiologicalProcess	regulation of developmental process	Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).		hp.json		http://purl.obolibrary.org/obo/GO_0050793		
GO:0050790	biolink:BiologicalProcess	regulation of catalytic activity	Any process that modulates the activity of an enzyme.		hp.json	regulation of enzyme activity|regulation of metalloenzyme activity	http://purl.obolibrary.org/obo/GO_0050790		goslim_chembl
GO:0060136	biolink:BiologicalProcess	embryonic process involved in female pregnancy	A reproductive process occurring in the embryo or fetus that allows the embryo or fetus to develop within the mother.		hp.json		http://purl.obolibrary.org/obo/GO_0060136		
GO:1904989	biolink:BiologicalProcess	positive regulation of endothelial cell activation	Any process that activates or increases the frequency, rate or extent of endothelial cell activation.		hp.json	activation of endothelial cell activation|upregulation of endothelial cell activation|up-regulation of endothelial cell activation|up regulation of endothelial cell activation	http://purl.obolibrary.org/obo/GO_1904989		
GO:1904988	biolink:BiologicalProcess	negative regulation of endothelial cell activation	Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation.		hp.json	down-regulation of endothelial cell activation|down regulation of endothelial cell activation|inhibition of endothelial cell activation|downregulation of endothelial cell activation	http://purl.obolibrary.org/obo/GO_1904988		
GO:1904987	biolink:BiologicalProcess	regulation of endothelial cell activation	Any process that modulates the frequency, rate or extent of endothelial cell activation.		hp.json		http://purl.obolibrary.org/obo/GO_1904987		
GO:0035112	biolink:BiologicalProcess	genitalia morphogenesis	The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.		hp.json	genital morphogenesis	http://purl.obolibrary.org/obo/GO_0035112		
GO:0060123	biolink:BiologicalProcess	regulation of growth hormone secretion	Any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060123		
GO:0060124	biolink:BiologicalProcess	positive regulation of growth hormone secretion	Any process that increases the frequency, rate or extent of the regulated release of growth hormone from a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060124		
GO:0060125	biolink:BiologicalProcess	negative regulation of growth hormone secretion	Any process that decreases or stops the frequency, rate or extent of the regulated release of growth hormone from a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060125		
GO:0072132	biolink:BiologicalProcess	mesenchyme morphogenesis	The process in which the anatomical structures of a mesenchymal tissue are generated and organized. A mesenchymal tissue is made up of loosely packed stellate cells.		hp.json		http://purl.obolibrary.org/obo/GO_0072132		
GO:1902339	biolink:BiologicalProcess	positive regulation of apoptotic process involved in morphogenesis	Any process that activates or increases the frequency, rate or extent of apoptotic process involved in morphogenesis.		hp.json	up regulation of apoptosis involved in morphogenesis|up regulation of apoptosis involved in development|positive regulation of apoptosis involved in morphogenesis|positive regulation of apoptosis involved in development|up-regulation of apoptotic process involved in morphogenesis|up-regulation of morphogenetic apoptosis|up regulation of apoptotic process involved in morphogenesis|upregulation of apoptosis involved in morphogenesis|upregulation of apoptosis involved in development|activation of apoptotic process involved in morphogenesis|activation of apoptosis involved in development|activation of apoptosis involved in morphogenesis|up regulation of morphogenetic apoptosis|positive regulation of morphogenetic apoptosis|upregulation of apoptotic process involved in morphogenesis|up-regulation of apoptosis involved in development|upregulation of morphogenetic apoptosis|up-regulation of apoptosis involved in morphogenesis|activation of morphogenetic apoptosis	http://purl.obolibrary.org/obo/GO_1902339		
GO:1902337	biolink:BiologicalProcess	regulation of apoptotic process involved in morphogenesis	Any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis.		hp.json	regulation of morphogenetic apoptosis|regulation of apoptosis involved in morphogenesis|regulation of apoptosis involved in development	http://purl.obolibrary.org/obo/GO_1902337		
GO:1902338	biolink:BiologicalProcess	negative regulation of apoptotic process involved in morphogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in morphogenesis.		hp.json	down regulation of morphogenetic apoptosis|inhibition of apoptosis involved in morphogenesis|inhibition of apoptotic process involved in morphogenesis|downregulation of apoptotic process involved in morphogenesis|inhibition of apoptosis involved in development|downregulation of morphogenetic apoptosis|negative regulation of apoptosis involved in morphogenesis|negative regulation of apoptosis involved in development|down-regulation of apoptosis involved in development|down-regulation of apoptosis involved in morphogenesis|down regulation of apoptosis involved in morphogenesis|down regulation of apoptosis involved in development|inhibition of morphogenetic apoptosis|down-regulation of apoptotic process involved in morphogenesis|downregulation of apoptosis involved in morphogenesis|down-regulation of morphogenetic apoptosis|negative regulation of morphogenetic apoptosis|downregulation of apoptosis involved in development|down regulation of apoptotic process involved in morphogenesis	http://purl.obolibrary.org/obo/GO_1902338		
HP:0009929	biolink:PhenotypicFeature	Abnormality of the columella	An abnormality of the columella.	UMLS:C4024158	hp.json	Anomaly of the columella|Deformity of the columella|Malformation of the columella	http://purl.obolibrary.org/obo/HP_0009929		
HP:0009926	biolink:PhenotypicFeature	Epiphora	Abnormally increased lacrimation, that is, excessive tearing (watering eye).	MSH:D007766|SNOMEDCT_US:193982009|SNOMEDCT_US:418035005|UMLS:C0152227	hp.json	Increased tears|Watery eyes|Tearing|Increased lacrimation	http://purl.obolibrary.org/obo/HP_0009926		hposlim_core
GO:1902340	biolink:BiologicalProcess	negative regulation of chromosome condensation	Any process that stops, prevents or reduces the frequency, rate or extent of chromosome condensation.		hp.json	down regulation of nuclear chromosome condensation|inhibition of nuclear chromosome condensation|down-regulation of chromosome condensation|downregulation of eukaryotic chromosome condensation|downregulation of nuclear chromosome condensation|down regulation of chromosome condensation|down regulation of eukaryotic chromosome condensation|inhibition of eukaryotic chromosome condensation|inhibition of chromosome condensation|downregulation of chromosome condensation|negative regulation of eukaryotic chromosome condensation|down-regulation of eukaryotic chromosome condensation|negative regulation of nuclear chromosome condensation|down-regulation of nuclear chromosome condensation	http://purl.obolibrary.org/obo/GO_1902340		
HP:0010926	biolink:PhenotypicFeature	Aculeiform cataract	A kind of nuclear cataract characterized by fiberglasslike or needlelike crystals projecting in different directions, through or close to the axial region of the lens.	MSH:C566162|UMLS:C1861832	hp.json	Needle-shaped cataract|Fasciculiform cataract|Frosted cataract	http://purl.obolibrary.org/obo/HP_0010926		
HP:0010925	biolink:PhenotypicFeature	Nuclear punctate cataract		UMLS:C4023649	hp.json		http://purl.obolibrary.org/obo/HP_0010925		
GO:0060156	biolink:NamedThing	milk ejection reflex			hp.json		http://purl.obolibrary.org/obo/GO_0060156		
HP:0009928	biolink:PhenotypicFeature	Thick nasal alae	Increase in bulk of the ala nasi.	UMLS:C1844809	hp.json	Thickening of the alae nasi|Ala nasi, thick	http://purl.obolibrary.org/obo/HP_0009928		hposlim_core
HP:0010924	biolink:PhenotypicFeature	Posterior cortical cataract	A cataract that affects the posterior part of the cortex of the lens.	UMLS:C4023650	hp.json		http://purl.obolibrary.org/obo/HP_0010924		
HP:0009927	biolink:PhenotypicFeature	Aplasia of the nose	Complete absence of all nasal structures.	MSH:C537438|UMLS:C0265740|SNOMEDCT_US:111317000|UMLS:C4280391	hp.json	Failure of development of nose|Missing nose|Underdevelopment of nose|Arrhinia|Absent nose|Nasal underdevelopment	http://purl.obolibrary.org/obo/HP_0009927		hposlim_core
HP:0010923	biolink:PhenotypicFeature	Anterior subcapsular cataract	A type of cataract affecting the anterior pole of lens immediately adjacent to ('beneath') the lens capsule.	SNOMEDCT_US:315352000|UMLS:C1112768	hp.json		http://purl.obolibrary.org/obo/HP_0010923		
HP:0009922	biolink:PhenotypicFeature	Vascular remnant arising from the disc	Persistence of the hyaloid artery, which is the embryonic artery that runs from the optic disk to the posterior lens capsule may persist; the site of attachment may form an opacity. The hyaloid artery is a branch of the ophthalmic artery, and usually regresses completely before birth.	UMLS:C4024160	hp.json	Persistent hyaloid artery|Persistence of the hyaloid artery	http://purl.obolibrary.org/obo/HP_0009922		
HP:0010922	biolink:PhenotypicFeature	Membranous cataract	A form of cataract in which the lens substance has shrunk, leaving a collapsed, flattened capsule with little or no cortex or epithelium on the lens.	MSH:D002386|UMLS:C0524524	hp.json		http://purl.obolibrary.org/obo/HP_0010922		
HP:0010921	biolink:PhenotypicFeature	Coralliform cataract	A 'coral-like' pattern of opacity in the lens of the eye. That is, a cataract with an irregular, stellate form.	UMLS:C1392104	hp.json		http://purl.obolibrary.org/obo/HP_0010921		
HP:0009921	biolink:PhenotypicFeature	Duane anomaly	A condition associated with a limitation of the horizontal ocular movement with retraction of the globe and narrowing of the palpebral fissure on adduction	SNOMEDCT_US:60318001|UMLS:C4072873|MSH:D004370|UMLS:C0013261|UMLS:C1846464	hp.json	Globe retraction and deviation on adduction|Limited eye motility from Duane anomaly|Limited eye movement from Duane anomaly	http://purl.obolibrary.org/obo/HP_0009921		hposlim_core
HP:0009924	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the nose	Underdevelopment or absence of the nose or parts thereof.	SNOMEDCT_US:204519007|UMLS:C0685684|SNOMEDCT_US:93278002|UMLS:C4024159|UMLS:C4280392	hp.json	Decreased nasal size|Hypoplasia of the nose|Decreased size of nose|Hypotrophic nose	http://purl.obolibrary.org/obo/HP_0009924		
HP:0010920	biolink:PhenotypicFeature	Zonular cataract	Zonular cataracts are defined to be cataracts that affect specific regions of the lens.	UMLS:C1861821|MSH:C535342	hp.json		http://purl.obolibrary.org/obo/HP_0010920		
GO:0035107	biolink:BiologicalProcess	appendage morphogenesis	The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.		hp.json		http://purl.obolibrary.org/obo/GO_0035107		
OBO:uberon/core#indirectly_supplies	biolink:NamedThing	indirectly_supplies	a indirectly_supplies s iff a has a branch and the branch supplies or indirectly supplies s.		hp.json		http://purl.obolibrary.org/obo/uberon/core#indirectly_supplies		
HP:0009920	biolink:PhenotypicFeature	Nevus of Ota	A dermal melanocytic hamartoma that presents as bluish hyperpigmentation on the face along the first or second branches of the trigeminal nerve. Nevus of Ota may involve the sclera.	UMLS:C0027961|SNOMEDCT_US:414929001|SNOMEDCT_US:254817005|MSH:D009507	hp.json	Oculodermal melanocytosis|Naevus fuscoceruleus ophthalmomaxillaris|Congenital melanosis bulbi|Nevus fuscoceruleus ophthalmomaxillaris	http://purl.obolibrary.org/obo/HP_0009920		
HP:0010929	biolink:PhenotypicFeature	Abnormal blood cation concentration	An abnormality of cation homeostasis.	UMLS:C4023646	hp.json	Abnormality of cation homeostasis	http://purl.obolibrary.org/obo/HP_0010929		
HP:0010928	biolink:PhenotypicFeature	obsolete Increased urinary orotic acid concentration			hp.json		http://purl.obolibrary.org/obo/HP_0010928		
HP:0010927	biolink:PhenotypicFeature	Abnormal blood inorganic cation concentration	An abnormality of divalent inorganic cation homeostasis.	UMLS:C4023648	hp.json	Abnormality of divalent inorganic cation homeostasis	http://purl.obolibrary.org/obo/HP_0010927		
GO:0098773	biolink:BiologicalProcess	skin epidermis development	The process whose specific outcome is the progression of the skin epidermis over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0098773		
GO:0098771	biolink:BiologicalProcess	inorganic ion homeostasis	Any process involved in the maintenance of an internal steady state of inorganic ions within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0098771		
GO:0060142	biolink:BiologicalProcess	regulation of syncytium formation by plasma membrane fusion	Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.		hp.json		http://purl.obolibrary.org/obo/GO_0060142		
GO:0060143	biolink:BiologicalProcess	positive regulation of syncytium formation by plasma membrane fusion	Any process that increases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.		hp.json		http://purl.obolibrary.org/obo/GO_0060143		
HP:0009937	biolink:PhenotypicFeature	Facial hirsutism	Excess facial hair.	UMLS:C2128203|UMLS:C1850041	hp.json	Excessive face hair	http://purl.obolibrary.org/obo/HP_0009937		
HP:0010915	biolink:PhenotypicFeature	Abnormal circulating pyruvate family amino acid concentration	An abnormality of a pyruvate family amino acid metabolic process.	UMLS:C4023655	hp.json	Abnormality of pyruvate family amino acid metabolism	http://purl.obolibrary.org/obo/HP_0010915		
HP:0009936	biolink:PhenotypicFeature	Narrow nasal septum	Abnormally narrow nasal septum.	UMLS:C4024155	hp.json	Thin septum of nose|Narrow septum of nose|Thin nasal septum|Decreased width of nasal septum|Narrow nasal septum	http://purl.obolibrary.org/obo/HP_0009936		hposlim_core
HP:0010914	biolink:PhenotypicFeature	Abnormal circulating valine concentration	Any deviation from the normal circulation of valine in the blood circulation.	UMLS:C4023656	hp.json	Abnormality of valine metabolism	http://purl.obolibrary.org/obo/HP_0010914		
HP:0009939	biolink:PhenotypicFeature	Mandibular aplasia	Absence of the mandible.	UMLS:C0685776|UMLS:C4021371|UMLS:C0685775|SNOMEDCT_US:91922000|SNOMEDCT_US:91896009	hp.json	Absence of lower jaw|Aplasia of the lower jaw bone|Absence of lower jaw bone|Failure of development of lower jaw|Absence of lower jaw bones|Failure of development of mandible|Agenesis of the mandible|Absent mandible|Agnathia|Absence of mandible|Missing lower jaw	http://purl.obolibrary.org/obo/HP_0009939		
HP:0010913	biolink:PhenotypicFeature	Hyperisoleucinemia	An increased concentration of isoleucine in the blood.	UMLS:C4023657	hp.json	High blood isoleucine concentration	http://purl.obolibrary.org/obo/HP_0010913		
HP:0010912	biolink:PhenotypicFeature	Abnormal circulating isoleucine concentration	Any deviation from the normal concentration of isoleucine in the blood circulation.	UMLS:C4023658	hp.json		http://purl.obolibrary.org/obo/HP_0010912		
HP:0009938	biolink:PhenotypicFeature	Sunken cheeks	Lack or loss of the soft tissues between the zygomata and mandible.	UMLS:C4024154	hp.json	Sunken cheeks|Hollow cheeks|Depressed cheeks	http://purl.obolibrary.org/obo/HP_0009938		hposlim_core
HP:0010911	biolink:PhenotypicFeature	Hyperleucinemia	An increased concentration of leucine in the blood.	SNOMEDCT_US:24013007|UMLS:C0268576	hp.json	High blood leucine concentration	http://purl.obolibrary.org/obo/HP_0010911		
HP:0009933	biolink:PhenotypicFeature	Narrow naris	Slender, slit-like aperture of the nostril.	UMLS:C0426436|UMLS:C1849366|SNOMEDCT_US:249336003|SNOMEDCT_US:249339005|UMLS:C4280390|UMLS:C0426439	hp.json	Slit-like nostrils|Naris, narrow|Thin nares|Naris, slit-like|Narrow nares|Small nostrils|Thin nostrils|Narrow nostrils|Collapsed nostrils	http://purl.obolibrary.org/obo/HP_0009933		hposlim_core
HP:0009932	biolink:PhenotypicFeature	Single naris	The presence of only a single nostril.	UMLS:C0685682|SNOMEDCT_US:95266003	hp.json	Single nare|Single nostril|One nostril|Mono nostril	http://purl.obolibrary.org/obo/HP_0009932		hposlim_core
HP:0010910	biolink:PhenotypicFeature	Hypervalinemia	An increased concentration of valine in the blood.	SNOMEDCT_US:47719001|MSH:C536524|UMLS:C0268573	hp.json	High blood valine concentration	http://purl.obolibrary.org/obo/HP_0010910		
HP:0009935	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the nasal septum	Absence or underdevelopment of the nasal septum.	UMLS:C4024156	hp.json	Underdevelopment of nasal septum|Ageneis of nasal septum|Failure of development of nasal septum	http://purl.obolibrary.org/obo/HP_0009935		
HP:0009934	biolink:PhenotypicFeature	Supernumerary naris	The presence of more than two nostrils.	UMLS:C4021372	hp.json	Extra nostril|Accessory nares|Supernumerary nares|Supernumerary nostrils|Accessory nostril	http://purl.obolibrary.org/obo/HP_0009934		hposlim_core
HP:0009931	biolink:PhenotypicFeature	Enlarged naris	Increased aperture of the nostril.	SNOMEDCT_US:399353008|UMLS:C0426440	hp.json	Increased diameter of nostril|Enlarged nares|Increased diameter of nares|Large nares|Wide nares|Naris, broad|Dilated nostril|Dilated nares|Naris, enlarged|Wide nostril|Enlarged nostril|Broad nostril|Increased width of nares	http://purl.obolibrary.org/obo/HP_0009931		hposlim_core
HP:0009930	biolink:PhenotypicFeature	Asymmetry of the nares	Asymmetry or size difference between the left and right nostril.	UMLS:C4024157	hp.json	Unequal nostril shape|Uneven nostril size|Uneven nostril shape|Asymmetry of nostrils|Crooked nostrils|Unequal nostril size	http://purl.obolibrary.org/obo/HP_0009930		hposlim_core
HP:0010919	biolink:PhenotypicFeature	Abnormal circulating homocysteine concentration	An abnormality of a homocysteine metabolic process.	UMLS:C4023651	hp.json		http://purl.obolibrary.org/obo/HP_0010919		
HP:0010918	biolink:PhenotypicFeature	Abnormal circulating cysteine concentration	An abnormality of a cysteine metabolic process.	UMLS:C4023652	hp.json		http://purl.obolibrary.org/obo/HP_0010918		
HP:0010917	biolink:PhenotypicFeature	Abnormal circulating tyrosine concentration	Any deviation from the normal concentration of tyrosine in the blood circulation.	UMLS:C4023653	hp.json		http://purl.obolibrary.org/obo/HP_0010917		
HP:0010916	biolink:PhenotypicFeature	Abnormal circulating alanine concentration	An abnormality of an alanine metabolic process.	UMLS:C4023654	hp.json	Abnormality of alanine metabolism	http://purl.obolibrary.org/obo/HP_0010916		
GO:0060170	biolink:CellularComponent	ciliary membrane	The portion of the plasma membrane surrounding a cilium.		hp.json	flagellar membrane|cilium membrane|flagellum membrane|cilial membrane	http://purl.obolibrary.org/obo/GO_0060170		
GO:1902358	biolink:BiologicalProcess	sulfate transmembrane transport	The directed movement of sulfate across a membrane.		hp.json		http://purl.obolibrary.org/obo/GO_1902358		
HP:0009908	biolink:PhenotypicFeature	Anterior creases of earlobe	Sharply demarcated, typically linear and approximately horizontal, indentations in the outer surface of the ear lobe.	UMLS:C1851897	hp.json	Transverse earlobe creases|Earlobe crease	http://purl.obolibrary.org/obo/HP_0009908		hposlim_core
GO:0060173	biolink:BiologicalProcess	limb development	The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.	Wikipedia:Limb_development	hp.json	paired limb/fin development|limb bud development	http://purl.obolibrary.org/obo/GO_0060173		
HP:0009907	biolink:PhenotypicFeature	Attached earlobe	Attachment of the lobe to the side of the face at the lowest point of the lobe without curving upward.	UMLS:C4021375	hp.json	Attached earlobe|Adherent earlobe	http://purl.obolibrary.org/obo/HP_0009907		hposlim_core
HP:0009909	biolink:PhenotypicFeature	Uplifted earlobe	An abnormal orientation of the earlobes such that they point out- and upward. That is, the lateral surface of ear lobe faces superiorly.	UMLS:C1856117	hp.json	Uplifted earlobes|Upturned earlobes|Upturned earlobe|Uplifted earlobe|Fleshy upturned lobules|Lobe, uplifted	http://purl.obolibrary.org/obo/HP_0009909		hposlim_core
HP:0010904	biolink:PhenotypicFeature	Abnormal circulating histidine concentration	An abnormality of a histidine metabolic process.	UMLS:C4023662	hp.json	Abnormality of histidine metabolism	http://purl.obolibrary.org/obo/HP_0010904		
GO:1902362	biolink:BiologicalProcess	melanocyte apoptotic process	Any apoptotic process in a melanocyte, the main structural component of the epidermis.		hp.json	melanophore apoptotic process|melanophore apoptosis|melanocyte apoptosis	http://purl.obolibrary.org/obo/GO_1902362		
HP:0009904	biolink:PhenotypicFeature	Prominent ear helix	Abnormally prominent ear helix.	UMLS:C4024165|UMLS:C4020776	hp.json	Large helix	http://purl.obolibrary.org/obo/HP_0009904		
HP:0009903	biolink:PhenotypicFeature	Conjunctival nodule	Presence of nodules in the conjunctiva of the eye.	SNOMEDCT_US:428477002|UMLS:C1996949	hp.json		http://purl.obolibrary.org/obo/HP_0009903		hposlim_core
HP:0010903	biolink:PhenotypicFeature	Abnormal circulating glutamine concentration	Any deviation from the normal concentration of glutamine in the blood circulation.	UMLS:C4023663	hp.json		http://purl.obolibrary.org/obo/HP_0010903		
HP:0009906	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the earlobes	Absence or underdevelopment of the ear lobes.	UMLS:C1851792	hp.json	Absent/small ear lobes|Absent/underdeveloped ear lobes	http://purl.obolibrary.org/obo/HP_0009906		
HP:0010902	biolink:PhenotypicFeature	Abnormal circulating glutamine family amino acid concentration	Any deviation from the normal concentration of a glutamine family amino acid in the blood circulation.	UMLS:C4023664	hp.json		http://purl.obolibrary.org/obo/HP_0010902		
HP:0009905	biolink:PhenotypicFeature	Thin ear helix	Decreased thickness of the helix of the ear.	UMLS:C4024164	hp.json		http://purl.obolibrary.org/obo/HP_0009905		hposlim_core
HP:0010901	biolink:PhenotypicFeature	Abnormal circulating methionine concentration	Any deviation from the normal concentration of methionine in the blood circulation.	UMLS:C4023665	hp.json	Abnormality of methionine metabolism	http://purl.obolibrary.org/obo/HP_0010901		
HP:0010900	biolink:PhenotypicFeature	Abnormal circulating threonine concentration	Any deviation from the normal concentration of threonine in the blood circulation.	UMLS:C4023666	hp.json	Abnormality of threonine metabolism	http://purl.obolibrary.org/obo/HP_0010900		
HP:0009900	biolink:PhenotypicFeature	Unilateral deafness	A unilateral absence of sensory perception of sound.	MSH:D046088|UMLS:C2607947|SNOMEDCT_US:162342008	hp.json	Deafness in one ear|Deafness, unilateral	http://purl.obolibrary.org/obo/HP_0009900		
HP:0009902	biolink:PhenotypicFeature	Cleft helix	A notched form of the helix of the ear. That is, a defect in the continuity of the helix, which may occur at any point along its length.	UMLS:C4021376	hp.json	Notched helix|Notching of the ear helix	http://purl.obolibrary.org/obo/HP_0009902		hposlim_core
HP:0009901	biolink:PhenotypicFeature	Crumpled ear	Distortion of the course of the normal folds of the ear and the appearance of supernumerary crura and folds.	UMLS:C4024166	hp.json	Crumpled ear	http://purl.obolibrary.org/obo/HP_0009901		hposlim_core
HP:0010909	biolink:PhenotypicFeature	Abnormal circulating arginine concentration	Any deviation from the normal concentration of arginine in the blood circulation.	UMLS:C4023659	hp.json	Abnormality of arginine metabolism	http://purl.obolibrary.org/obo/HP_0010909		
HP:0010908	biolink:PhenotypicFeature	Abnormal circulating lysine concentration	Any deviation from the normal concentration of lysine in the blood circulation.	UMLS:C4023660	hp.json	Abnormality of lysine metabolism	http://purl.obolibrary.org/obo/HP_0010908		
HP:0010907	biolink:PhenotypicFeature	Abnormal circulating proline concentration	Any deviation from the normal concentration of proline or a proline metabolite in the blood circulation.	UMLS:C4023661	hp.json		http://purl.obolibrary.org/obo/HP_0010907		
HP:0010906	biolink:PhenotypicFeature	Hyperhistidinemia	An increased concentration of histidine in the blood.	SNOMEDCT_US:124628005|MSH:C538320|SNOMEDCT_US:410058007|UMLS:C0220992	hp.json	Histidinemia|High blood histidine level	http://purl.obolibrary.org/obo/HP_0010906		
HP:0010905	biolink:PhenotypicFeature	obsolete Abnormality of histidine metabolism			hp.json		http://purl.obolibrary.org/obo/HP_0010905		
GO:0098751	biolink:BiologicalProcess	bone cell development	The process whose specific outcome is the progression of a bone cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0098751		gocheck_do_not_annotate
HP:0009919	biolink:PhenotypicFeature	Retinoblastoma	A tumor of the eye originating from cells of the retina.	SNOMEDCT_US:127002001|UMLS:C0035335|UMLS:C0524801|MSH:D012175|SNOMEDCT_US:370967009|NCIT:C7541|SNOMEDCT_US:19906005|MSH:D019572	hp.json	Retina tumour|Retina tumor	http://purl.obolibrary.org/obo/HP_0009919		
HP:0009918	biolink:PhenotypicFeature	Ectopia pupillae	A malposition of the pupil owing to a developmental defect of the iris.	SNOMEDCT_US:392461003|SNOMEDCT_US:193523008|UMLS:C1271219|MSH:C536185	hp.json	Corectopia|Displaced pupil	http://purl.obolibrary.org/obo/HP_0009918		hposlim_core
HP:0009915	biolink:PhenotypicFeature	Corneal asymmetry	The presence of a size difference between the left and right cornea.	UMLS:C4021373	hp.json	Asymmetry of the corneas	http://purl.obolibrary.org/obo/HP_0009915		hposlim_core
HP:0009914	biolink:PhenotypicFeature	Cyclopia	Cyclopia is a congenital abnormality in which there is only one eye. That eye is centrally placed in the area normally occupied by the root of the nose.	UMLS:C0266667|MSH:C562573|SNOMEDCT_US:205798005	hp.json	Single central eye|Cyclops eye	http://purl.obolibrary.org/obo/HP_0009914		hposlim_core
HP:0009917	biolink:PhenotypicFeature	Persistent pupillary membrane	The presence of remnants of a fetal membrane that persist as strands of tissue crossing the pupil.	UMLS:C0344541|SNOMEDCT_US:95500008	hp.json		http://purl.obolibrary.org/obo/HP_0009917		
HP:0009916	biolink:PhenotypicFeature	Anisocoria	Anisocoria, or unequal pupil size, may represent a benign physiologic variant or a manifestation of disease.	UMLS:C0003079|SNOMEDCT_US:13045009|MSH:D015875	hp.json	Asymmetric pupil sizes|Unequal pupil dilatation|Unequal pupil size|Asymmetry of the pupils	http://purl.obolibrary.org/obo/HP_0009916		hposlim_core
HP:0009911	biolink:PhenotypicFeature	Abnormal temporal bone morphology	Abnormality of the temporal bone of the skull, which is situated at the sides and base of the skull roughly underlying the region of the face known as the temple.	UMLS:C4024163	hp.json	Abnormality of the temporal bone	http://purl.obolibrary.org/obo/HP_0009911		hposlim_core
HP:0009910	biolink:PhenotypicFeature	Aplasia of the middle ear ossicles	Absence of the middle ear ossicles, malleus, incus, and stapes.	UMLS:C4021374	hp.json	Absent middle ear bones|Absent middle ear ossicles	http://purl.obolibrary.org/obo/HP_0009910		
HP:0009913	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the tragus	Aplasia or developmental hypoplasia of the tragus.	UMLS:C4024161	hp.json	Absent/small tragus|Absent/underdeveloped tragus	http://purl.obolibrary.org/obo/HP_0009913		
HP:0009912	biolink:PhenotypicFeature	Abnormal tragus morphology	An abnormality of the tragus.	UMLS:C4024162	hp.json	Abnormality of the tragus	http://purl.obolibrary.org/obo/HP_0009912		
GO:0050709	biolink:BiologicalProcess	negative regulation of protein secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.		hp.json	down-regulation of protein secretion|down regulation of protein secretion|inhibition of protein secretion|downregulation of protein secretion	http://purl.obolibrary.org/obo/GO_0050709		
GO:0050708	biolink:BiologicalProcess	regulation of protein secretion	Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0050708		
CL:0002264	biolink:Cell	type A cell of stomach	A type of enteroendocrine cell found in the stomach that secretes glucagon.	FMA:83411	hp.json		http://purl.obolibrary.org/obo/CL_0002264		
CHEBI:62488	biolink:ChemicalSubstance	signalling molecule	A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell.		hp.json	signal molecule|signaling molecule|signalling molecules|signaling molecules|signal molecules	http://purl.obolibrary.org/obo/CHEBI_62488		3_STAR
CL:0002261	biolink:Cell	endothelial cell of viscerocranial mucosa	An endothelial cell found in the mucosa associated with the facial skeleton.	FMA:70627	hp.json		http://purl.obolibrary.org/obo/CL_0002261		
CL:0002260	biolink:Cell	epithelial cell of parathyroid gland	An epithelial cell of the parathyroid gland.	FMA:70547	hp.json		http://purl.obolibrary.org/obo/CL_0002260		
CL:0002262	biolink:Cell	endothelial cell of sinusoid	An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.	FMA:63134	hp.json		http://purl.obolibrary.org/obo/CL_0002262		
CHEBI:25500	biolink:ChemicalSubstance	neopterins			hp.json		http://purl.obolibrary.org/obo/CHEBI_25500		3_STAR
GO:0050714	biolink:BiologicalProcess	positive regulation of protein secretion	Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.		hp.json	upregulation of protein secretion|up-regulation of protein secretion|up regulation of protein secretion|activation of protein secretion|stimulation of protein secretion	http://purl.obolibrary.org/obo/GO_0050714		
CHEBI:62499	biolink:ChemicalSubstance	methyl-branched fatty acid	Any branched-chain fatty acid containing methyl branches only.	PMID:17030019|PMID:19933331|PMID:19747846	hp.json	methyl-branched fatty acids	http://purl.obolibrary.org/obo/CHEBI_62499		3_STAR
CHEBI:25508	biolink:ChemicalSubstance	neuraminic acids			hp.json		http://purl.obolibrary.org/obo/CHEBI_25508		3_STAR
CHEBI:25506	biolink:ChemicalSubstance	neuraminates			hp.json		http://purl.obolibrary.org/obo/CHEBI_25506		3_STAR
CL:0002274	biolink:Cell	histamine secreting cell	A cell type that secretes histamine.		hp.json		http://purl.obolibrary.org/obo/CL_0002274		
GO:0050727	biolink:BiologicalProcess	regulation of inflammatory response	Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.		hp.json		http://purl.obolibrary.org/obo/GO_0050727		
GO:0050728	biolink:BiologicalProcess	negative regulation of inflammatory response	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.		hp.json	anti-inflammatory response|down-regulation of inflammatory response|down regulation of inflammatory response|downregulation of inflammatory response|inhibition of inflammatory response	http://purl.obolibrary.org/obo/GO_0050728		
GO:0050729	biolink:BiologicalProcess	positive regulation of inflammatory response	Any process that activates or increases the frequency, rate or extent of the inflammatory response.		hp.json	up regulation of inflammatory response|activation of inflammatory response|stimulation of inflammatory response|upregulation of inflammatory response|up-regulation of inflammatory response	http://purl.obolibrary.org/obo/GO_0050729		
CL:0002242	biolink:Cell	nucleate cell	A cell containing at least one nucleus.	FMA:67513	hp.json		http://purl.obolibrary.org/obo/CL_0002242		
CL:0002246	biolink:Cell	peripheral blood stem cell	A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells).	BTO:0002669|FMA:86711	hp.json	PBSC	http://purl.obolibrary.org/obo/CL_0002246		
CL:0002240	biolink:Cell	marrow fibroblast	A fibroblast in the bone marrow.	FMA:84377	hp.json		http://purl.obolibrary.org/obo/CL_0002240		
CL:0002253	biolink:Cell	epithelial cell of large intestine	An epithelial cell of the large intestine.	FMA:256157|BTO:0004297	hp.json	epithelial cell of colon	http://purl.obolibrary.org/obo/CL_0002253		
CL:0002255	biolink:Cell	stromal cell of endometrium	Connective tissue cells of the endometrium, these cells are fibroblastic in appearance. During decidualization they tranform into decidual (stromal) cells, swellling up and adopt an epithelial cell-like appearance due to the accumulation of glycogen and lipid droplets.	CALOHA:TS-1266|FMA:86490	hp.json	endometrial stromal cell	http://purl.obolibrary.org/obo/CL_0002255		
CL:0002258	biolink:Cell	thyroid follicular cell	A cell type that varies from squamous to columnar, depending on their activity with microvillus directed luminally. This cell produces and secretes thyroid hormones.	FMA:68782|CALOHA:TS-1285|BTO:0003736	hp.json	principal cell of thyroid gland|follicular cell of thyroid gland|thyroid gland follicular cell	http://purl.obolibrary.org/obo/CL_0002258		
CL:0002257	biolink:Cell	epithelial cell of thyroid gland	An epithelial cell of thyroid gland.	FMA:256167	hp.json		http://purl.obolibrary.org/obo/CL_0002257		
CL:0002252	biolink:Cell	epithelial cell of esophagus	An epithelial cell of the esophagus.	FMA:63071	hp.json		http://purl.obolibrary.org/obo/CL_0002252		
CL:0002251	biolink:Cell	epithelial cell of alimentary canal	An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus.		hp.json		http://purl.obolibrary.org/obo/CL_0002251		
HP:0032270	biolink:PhenotypicFeature	Optic nerve tram-track sign	A tram-track sign is composed of two enhancing areas of tumor separated from each other by the negative defect of the optic nerve. It is seen on contrast-enhanced CT scan and MRI images, in optic nerve sheath meningioma. The sign helps distinguish between optic nerve sheath meningioma and optic glioma. Optic glioma arises from glial cells within the optic nerve and there is no clear separation between the nerve and the tumor; hence the tram-track sign is not seen in optic gliomas. Calcification may be seen in optic nerve sheath meningiomas in 20-50% of cases and hence the tram-track sign may be seen on nonenhanced CT scan images as a linear calcification around the nerve, but this is less common.		hp.json		http://purl.obolibrary.org/obo/HP_0032270		
HP:0032271	biolink:PhenotypicFeature	Extrapulmonary tuberculosis	A type of tubercular infection located outside of the lung, which is the most common location of tuberculosis. There are two types of clinical manifestation of tuberculosis (TB) are pulmonary TB (PTB) and extrapulmonary TB (EPTB). The former is most common. EPTB refers to TB involving organs other than the lungs (e.g., pleura, lymph nodes, abdomen, genitourinary tract, skin, joints and bones, or meninges). A patient with both pulmonary and EPTB is classified as a case of PTB.		hp.json	Extrapulmonary TB	http://purl.obolibrary.org/obo/HP_0032271		
HP:0032272	biolink:PhenotypicFeature	Elevated urinary N-acetylaspartic acid level	Elevated N-acetylaspartic acid (NAA) in urine. This feature can be measured using gas chromatography-mass spectrometry.		hp.json		http://purl.obolibrary.org/obo/HP_0032272		
GO:0035190	biolink:BiologicalProcess	syncytial nuclear migration	The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex.		hp.json		http://purl.obolibrary.org/obo/GO_0035190		
HP:0032277	biolink:PhenotypicFeature	Lozenge-shaped umbilicus			hp.json		http://purl.obolibrary.org/obo/HP_0032277		
HP:0032278	biolink:PhenotypicFeature	2-hydroxyglutarate aciduria	An increase in the level of 2-hydroxyglutaric acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032278		
HP:0032273	biolink:PhenotypicFeature	Increased circulating N-Acetylaspartic acid concentration	An abnormally increased concentration of N-Acetylaspartic acid in the blood circulation.		hp.json	Increased circulating NAA level|Increased circulating N-acetyl-L-aspartic acid level|Increased circulating N-acetyl aspartic acid level|Increased circulating N-acetyl aspartate level|Increased circulating N-acetylaspartate level	http://purl.obolibrary.org/obo/HP_0032273		
HP:0032274	biolink:PhenotypicFeature	Increased CSF N-acetylaspartic acid concentration	An abnormally increased concentration of N-acetylaspartic acid in the cerebrospinal fluid (CSF).		hp.json	Increased N-acetylaspartate levels in CSF|Increased N-acetyl-L-aspartic acid levels in CSF|Increased NAA levels in CSF|Increased N-acetyl aspartic acid levels in CSF|Increased N-acetyl aspartate levels in CSF	http://purl.obolibrary.org/obo/HP_0032274		
CHEBI:86499	biolink:ChemicalSubstance	monohydroxyproline	A hydroxy-amino acid in which the amino acid specified is proline. A "closed" class.		hp.json		http://purl.obolibrary.org/obo/CHEBI_86499		3_STAR
HP:0032275	biolink:PhenotypicFeature	Recurrent shingles	Repeated episodes of a localized, painful cutaneous eruption related to reactivation of varicella zoster virus (VZV) and characterized by a characteristic rash in one or two adjacent dermatomes.		hp.json		http://purl.obolibrary.org/obo/HP_0032275		
HP:0032276	biolink:PhenotypicFeature	Prominent subcalcaneal fat pad	Abnormally increased prominence of the fat pad underneath the heal. This feature can be appreciated in figure 1 of PMID:26769062.		hp.json		http://purl.obolibrary.org/obo/HP_0032276		
CL:0002220	biolink:Cell	interstitial cell of pineal gland	A cell located between the pinealocytes.	FMA:86575	hp.json		http://purl.obolibrary.org/obo/CL_0002220		
CL:1000497	biolink:Cell	kidney cell		KUPO:0001010	hp.json		http://purl.obolibrary.org/obo/CL_1000497		
CL:0002222	biolink:Cell	vertebrate lens cell	A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye.	FMA:70950	hp.json		http://purl.obolibrary.org/obo/CL_0002222		
CL:0002224	biolink:Cell	lens epithelial cell	A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.	FMA:67559	hp.json		http://purl.obolibrary.org/obo/CL_0002224		
CL:1000493	biolink:Cell	mesothelial cell of visceral pleura	A mesothelial cell that is part of the visceral pleura.	FMA:86739	hp.json		http://purl.obolibrary.org/obo/CL_1000493		
CL:1000492	biolink:Cell	mesothelial cell of parietal pleura	A mesothelial cell that is part of the parietal pleura.	FMA:86738	hp.json		http://purl.obolibrary.org/obo/CL_1000492		
CL:1000491	biolink:Cell	mesothelial cell of pleura	A mesothelial cell that is part of the pleura.	FMA:86737	hp.json	pleural mesothelial cell	http://purl.obolibrary.org/obo/CL_1000491		
CL:1000490	biolink:Cell	mesothelial cell of peritoneum	A mesothelial cell that is part of the peritoneum.	FMA:86736	hp.json	peritoneal mesothelial cell	http://purl.obolibrary.org/obo/CL_1000490		
HP:0032281	biolink:PhenotypicFeature	Abnormal base excess	Deviation from the normal quantity of base excess, defined as the amount of strong acid (in millimoles per liter) that needs to be added in vitro to 1 liter of fully oxygenated whole blood to return a blood sample to standard conditions (pH of 7.40, Pco2 of 40 mm Hg, and temperature of 37 degrees C).		hp.json		http://purl.obolibrary.org/obo/HP_0032281		
HP:0032282	biolink:PhenotypicFeature	Contact dermatitis	An inflammatory process in skin caused by an exogenous agent that directly or indirectly injure the skin. If the offending agent is identified and removed, the eruption will resolve. An unusual or patterned eruption may be a clue to the presence of a contact dermatitis. Patch testing may be helpful in the differential diagnosis.		hp.json		http://purl.obolibrary.org/obo/HP_0032282		
HP:0032283	biolink:PhenotypicFeature	Disseminated nontuberculous mycobacterial infection	An infection with nontuberculous mycobacteria that affects multiple body sites. Such infections can occur in individuals with immune disease.		hp.json		http://purl.obolibrary.org/obo/HP_0032283		
HP:0032288	biolink:PhenotypicFeature	Polyclonal elevation of circulating IgG	An increase in polyclonal immunoglobulins resulting from many different plasma cells. On serum electrophoresis, a polyclonal gammopathy is characterized by a broad diffuse band with one or more heavy chains and kappa and lambda light chains.		hp.json		http://purl.obolibrary.org/obo/HP_0032288		
HP:0032289	biolink:PhenotypicFeature	Oligoclonal elevation of circulating IgG	An increase in circulating immunoglobulins characterized by two or more bands in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.		hp.json		http://purl.obolibrary.org/obo/HP_0032289		
HP:0032284	biolink:PhenotypicFeature	Ultra-low vision with retained motion projection	Ultra-low vision but with retained ability to identify a moving object (typically hand motion at distance of 30 cm).		hp.json		http://purl.obolibrary.org/obo/HP_0032284		
HP:0032285	biolink:PhenotypicFeature	Ultra-low vision with retained light projection	Ultra-low vision but with retained ability to perceive the difference between light and dark. Also when light is projected in each of the four quadrants of the visual field, the individual is able to correctly identify the origin of the light stimulus.		hp.json		http://purl.obolibrary.org/obo/HP_0032285		
HP:0032286	biolink:PhenotypicFeature	Ultra-low vision with retained light perception	Ultra-low vision but with retained ability to perceive the difference between light and dark.		hp.json		http://purl.obolibrary.org/obo/HP_0032286		
HP:0032287	biolink:PhenotypicFeature	Ultra-low vision with no light perception	Ultra-low vision with complete lack of light and form perception.		hp.json		http://purl.obolibrary.org/obo/HP_0032287		
CL:1000488	biolink:Cell	cholangiocyte	An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.	FMA:86481	hp.json	epithelial cell of bile duct	http://purl.obolibrary.org/obo/CL_1000488		
CL:1000487	biolink:Cell	smooth muscle cell of prostate	A smooth muscle cell that is part of the prostate gland.	FMA:84583	hp.json	smooth muscle fiber of prostate	http://purl.obolibrary.org/obo/CL_1000487		
CL:1000482	biolink:Cell	myocardial endocrine cell of interventricular septum	A myocardial endocrine cell that is part of the interventricular septum.	FMA:83390	hp.json		http://purl.obolibrary.org/obo/CL_1000482		
HP:0032291	biolink:PhenotypicFeature	Monoclonal elevation of intact IgG	A type of monoclonal elevation of IgG in which the involved immunoglobulin has a normal structure with a light and heavy chain.		hp.json		http://purl.obolibrary.org/obo/HP_0032291		
HP:0032292	biolink:PhenotypicFeature	Monoclonal elevation of IgG light chain	A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a light chain but not a heavy chain.		hp.json		http://purl.obolibrary.org/obo/HP_0032292		
GO:0050764	biolink:BiologicalProcess	regulation of phagocytosis	Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.		hp.json		http://purl.obolibrary.org/obo/GO_0050764		
HP:0032293	biolink:PhenotypicFeature	Monoclonal elevation of IgG heavy chain	A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a heavy chain but not a light chain.		hp.json		http://purl.obolibrary.org/obo/HP_0032293		
HP:0032294	biolink:PhenotypicFeature	Monoclonal elevation of IgG kappa chain	A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a kappa light chain but not a heavy chain.		hp.json		http://purl.obolibrary.org/obo/HP_0032294		
GO:0050767	biolink:BiologicalProcess	regulation of neurogenesis	Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0050767		
GO:1904937	biolink:BiologicalProcess	sensory neuron migration	The orderly movement of a sensory neuron from one site to another.		hp.json		http://purl.obolibrary.org/obo/GO_1904937		
GO:0050768	biolink:BiologicalProcess	negative regulation of neurogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.		hp.json	downregulation of neurogenesis|down regulation of neurogenesis|inhibition of neurogenesis|down-regulation of neurogenesis	http://purl.obolibrary.org/obo/GO_0050768		
GO:0050765	biolink:BiologicalProcess	negative regulation of phagocytosis	Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.		hp.json	downregulation of phagocytosis|down regulation of phagocytosis|inhibition of phagocytosis|down-regulation of phagocytosis	http://purl.obolibrary.org/obo/GO_0050765		
GO:1904936	biolink:BiologicalProcess	interneuron migration	The orderly movement of an interneuron from one site to another.		hp.json	inter neuron migration|inter-neuron migration	http://purl.obolibrary.org/obo/GO_1904936		
GO:1904935	biolink:BiologicalProcess	positive regulation of cell proliferation in midbrain	Any process that activates or increases the frequency, rate or extent of cell proliferation in midbrain.		hp.json	up regulation of cell proliferation in mesencephalon|positive regulation of cell proliferation in mesencephalon|upregulation of mesencepahalic cell proliferation|upregulation of cell proliferation in midbrain|activation of cell proliferation in mesencephalon|activation of mesencepahalic cell proliferation|upregulation of cell proliferation in mesencephalon|up regulation of cell proliferation in midbrain|up-regulation of mesencepahalic cell proliferation|up-regulation of cell proliferation in midbrain|activation of cell proliferation in midbrain|up regulation of mesencepahalic cell proliferation|up-regulation of cell proliferation in mesencephalon|positive regulation of mesencepahalic cell proliferation	http://purl.obolibrary.org/obo/GO_1904935		
GO:0050766	biolink:BiologicalProcess	positive regulation of phagocytosis	Any process that activates or increases the frequency, rate or extent of phagocytosis.		hp.json	stimulation of phagocytosis|up regulation of phagocytosis|activation of phagocytosis|up-regulation of phagocytosis|upregulation of phagocytosis	http://purl.obolibrary.org/obo/GO_0050766		
HP:0032290	biolink:PhenotypicFeature	Monoclonal elevation of IgG	An increase in circulating immunoglobulins characterized by a single band in serum electrophoresis but not the broad diffuse band that characterizes a polyclonal increase in circulating immunoglobulins.		hp.json		http://purl.obolibrary.org/obo/HP_0032290		
GO:1904934	biolink:BiologicalProcess	negative regulation of cell proliferation in midbrain	Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation in midbrain.		hp.json	inhibition of cell proliferation in midbrain|down-regulation of mesencepahalic cell proliferation|down-regulation of cell proliferation in midbrain|negative regulation of mesencepahalic cell proliferation|down regulation of mesencepahalic cell proliferation|negative regulation of cell proliferation in mesencephalon|down-regulation of cell proliferation in mesencephalon|downregulation of mesencepahalic cell proliferation|down regulation of cell proliferation in mesencephalon|downregulation of cell proliferation in midbrain|inhibition of cell proliferation in mesencephalon|downregulation of cell proliferation in mesencephalon|inhibition of mesencepahalic cell proliferation|down regulation of cell proliferation in midbrain	http://purl.obolibrary.org/obo/GO_1904934		
HP:0032299	biolink:PhenotypicFeature	Increased circulating IgG2 level	An abnormally increased concentration of the IgG2 subtype in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032299		
GO:1904933	biolink:BiologicalProcess	regulation of cell proliferation in midbrain	Any process that modulates the frequency, rate or extent of cell proliferation in midbrain.		hp.json	regulation of mesencepahalic cell proliferation|regulation of cell proliferation in mesencephalon	http://purl.obolibrary.org/obo/GO_1904933		
GO:0050769	biolink:BiologicalProcess	positive regulation of neurogenesis	Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.		hp.json	up regulation of neurogenesis|stimulation of neurogenesis|up-regulation of neurogenesis|activation of neurogenesis|upregulation of neurogenesis	http://purl.obolibrary.org/obo/GO_0050769		
CL:0002209	biolink:Cell	intermediate epitheliocyte	An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells.	FMA:69060	hp.json	undifferentiated columnar cell of tracheobronchial tree	http://purl.obolibrary.org/obo/CL_0002209		
HP:0032295	biolink:PhenotypicFeature	Monoclonal elevation of IgG lambda chain	A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a lambda light chain but not a heavy chain.		hp.json		http://purl.obolibrary.org/obo/HP_0032295		
HP:0032296	biolink:PhenotypicFeature	Increased circulating IgG subclass	An elevation of circulating IgG level predominantly related to an elevation of one of the four IgG subclasses.		hp.json		http://purl.obolibrary.org/obo/HP_0032296		
HP:0032297	biolink:PhenotypicFeature	Increased circulating IgG3 level	An abnormally increased concentration of the IgG3 subtype in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032297		
HP:0032298	biolink:PhenotypicFeature	Increased circulating IgG1 level	An abnormally increased concentration of the IgG1 subtype in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032298		
CL:0002202	biolink:Cell	epithelial cell of tracheobronchial tree	An epithelial cell of the tracheobronchial tree.	FMA:66816	hp.json		http://purl.obolibrary.org/obo/CL_0002202		
GO:0050772	biolink:BiologicalProcess	positive regulation of axonogenesis	Any process that activates or increases the frequency, rate or extent of axonogenesis.		hp.json	upregulation of axonogenesis|up regulation of axonogenesis|stimulation of axonogenesis|up-regulation of axonogenesis|activation of axonogenesis	http://purl.obolibrary.org/obo/GO_0050772		
GO:0050778	biolink:BiologicalProcess	positive regulation of immune response	Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.		hp.json	stimulation of immune response|upregulation of immune response|up-regulation of immune response|up regulation of immune response	http://purl.obolibrary.org/obo/GO_0050778		
GO:0050776	biolink:BiologicalProcess	regulation of immune response	Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0050776		
GO:0050777	biolink:BiologicalProcess	negative regulation of immune response	Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.		hp.json	down-regulation of immune response|down regulation of immune response|inhibition of immune response|downregulation of immune response	http://purl.obolibrary.org/obo/GO_0050777		
GO:1904944	biolink:BiologicalProcess	positive regulation of cardiac ventricle formation	Any process that activates or increases the frequency, rate or extent of cardiac ventricle formation.		hp.json	up regulation of cardiac ventricle formation|activation of cardiac ventricle formation|upregulation of cardiac ventricle formation|up-regulation of cardiac ventricle formation	http://purl.obolibrary.org/obo/GO_1904944		
GO:1904943	biolink:BiologicalProcess	negative regulation of cardiac ventricle formation	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle formation.		hp.json	down-regulation of cardiac ventricle formation|down regulation of cardiac ventricle formation|downregulation of cardiac ventricle formation|inhibition of cardiac ventricle formation	http://purl.obolibrary.org/obo/GO_1904943		
GO:1904942	biolink:BiologicalProcess	regulation of cardiac ventricle formation	Any process that modulates the frequency, rate or extent of cardiac ventricle formation.		hp.json		http://purl.obolibrary.org/obo/GO_1904942		
GO:0050770	biolink:BiologicalProcess	regulation of axonogenesis	Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.		hp.json		http://purl.obolibrary.org/obo/GO_0050770		
GO:0050771	biolink:BiologicalProcess	negative regulation of axonogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.		hp.json	down regulation of axonogenesis|inhibition of axonogenesis|down-regulation of axonogenesis|downregulation of axonogenesis	http://purl.obolibrary.org/obo/GO_0050771		
HP:0009690	biolink:PhenotypicFeature	Fragmentation of thumb epiphysis	Epiphysis of the thumb having multiple bony fragments.	UMLS:C4021405	hp.json	Fragmentation of the epiphyses of the thumb|Fragmentation of end part of long bone of thumb	http://purl.obolibrary.org/obo/HP_0009690		
UBERON:0000219	biolink:AnatomicalEntity	vertebral foramen of atlas		FMA:24293	hp.json	vertebral foramen of cervical vertebra 1	http://purl.obolibrary.org/obo/UBERON_0000219		
HP:0009692	biolink:PhenotypicFeature	Ivory epiphysis of the thumb	Sclerosis of one or more of the epiphyses of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4021403	hp.json	Increased bone density of end part of the thumb|Ivory epiphyses of the thumb	http://purl.obolibrary.org/obo/HP_0009692		
HP:0009691	biolink:PhenotypicFeature	Irregular thumb epiphysis	Uneven radiographic opacity of the one or more epiphyses of the thumb.	UMLS:C4021404	hp.json	Irregular epiphyses of the thumb|Irregular end part of thumb long bone	http://purl.obolibrary.org/obo/HP_0009691		
HP:0007030	biolink:PhenotypicFeature	Nonprogressive encephalopathy		UMLS:C4024950	hp.json		http://purl.obolibrary.org/obo/HP_0007030		
HP:0020006	biolink:PhenotypicFeature	Ciliary body coloboma	A coloboma of the ciliary body.	UMLS:C4072884	hp.json		http://purl.obolibrary.org/obo/HP_0020006		
UBERON:0000218	biolink:AnatomicalEntity	vertebral arch of axis	A neural arch that is part of a vertebral bone 2.	FMA:24053	hp.json	vertebral foramen of cervical vertebra 2	http://purl.obolibrary.org/obo/UBERON_0000218		
HP:0010687	biolink:PhenotypicFeature	Low intestinal alkaline phosphatase	An abnormally reduced level of alkaline phosphatase, intestinal type in the blood.	UMLS:C4023738	hp.json	Low intestinal ALP	http://purl.obolibrary.org/obo/HP_0010687		
HP:0010686	biolink:PhenotypicFeature	Low alkaline phosphatase of hepatic origin	An abnormally reduced level of liver isoforms of alkaline phosphatase in the blood.	UMLS:C4023739	hp.json	Low ALP of hepatic origin	http://purl.obolibrary.org/obo/HP_0010686		
HP:0010685	biolink:PhenotypicFeature	Low alkaline phosphatase of renal origin	An abnormally reduced level of kidney isoforms of alkaline phosphatase in the blood.	UMLS:C4023740	hp.json	Low ALP of renal origin	http://purl.obolibrary.org/obo/HP_0010685		
HP:0010684	biolink:PhenotypicFeature	Low alkaline phosphatase of bone origin	An abnormally reduced level of bone isoforms of alkaline phosphatase in the blood.	UMLS:C4023741	hp.json	Low ALP of bone origin	http://purl.obolibrary.org/obo/HP_0010684		
HP:0010683	biolink:PhenotypicFeature	Low tissue non-specific alkaline phosphatase	An abnormally reduced level of alkaline phosphatase, tissue-nonspecific isozyme in the blood.	UMLS:C4023742	hp.json	Low tissue non-specific ALP	http://purl.obolibrary.org/obo/HP_0010683		
HP:0010682	biolink:PhenotypicFeature	Elevated placental alkaline phosphatase	An abnormally increased level of alkaline phosphatase, placental type in the blood.	UMLS:C4023743	hp.json	Elevated placental ALP	http://purl.obolibrary.org/obo/HP_0010682		
HP:0010681	biolink:PhenotypicFeature	Elevated intestinal alkaline phosphatase	An abnormally increased level of alkaline phosphatase, intestinal type in the blood.	UMLS:C4023744	hp.json	Elevated intestinal ALP	http://purl.obolibrary.org/obo/HP_0010681		
HP:0010680	biolink:PhenotypicFeature	Elevated alkaline phosphatase of renal origin	An abnormally increased level of kidney isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood.	UMLS:C4023745	hp.json	Elevated ALP of renal origin	http://purl.obolibrary.org/obo/HP_0010680		
HP:0007029	biolink:PhenotypicFeature	Cerebral berry aneurysm	A small, sac-like aneurysm (outpouching) of a cerebral blood vessel.	UMLS:C2713497|MSH:D000783|SNOMEDCT_US:54002007	hp.json	Cerebral saccular aneurysm	http://purl.obolibrary.org/obo/HP_0007029		
HP:0010689	biolink:PhenotypicFeature	Mirror image polydactyly	A hand or foot with more than five digits that has a recognizable A/P axis of symmetry. The axis can lie within a normally formed or partially duplicated digit resembling a middle finger, index finger, thumb, toe, or hallux. Alternatively, the axis can be in an interdigital space with a flanking pair of digits that resemble a middle finger, index finger, thumb, toe or hallux. The most lateral digits on each side of the hand/foot typically resemble fifth fingers/toes.	MSH:C535689|SNOMEDCT_US:715440003|UMLS:C1851100	hp.json	Mirror image duplication of digits	http://purl.obolibrary.org/obo/HP_0010689		
HP:0010688	biolink:PhenotypicFeature	Low placental alkaline phosphatase	An abnormally reduced level of alkaline phosphatase, placental type in the blood.	UMLS:C4023737	hp.json	Low placental ALP	http://purl.obolibrary.org/obo/HP_0010688		
HP:0009687	biolink:PhenotypicFeature	Bracket epiphyses of the thumb	An abnormality of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024232	hp.json	Bracket shaped end part of the thumb bone	http://purl.obolibrary.org/obo/HP_0009687		
HP:0007024	biolink:PhenotypicFeature	Pseudobulbar paralysis	Bilateral impairment of the function of the cranial nerves 9-12, which control musculature involved in eating, swallowing, and speech. Pseudobulbar paralysis is characterized clinically by dysarthria, dysphonia, and dysphagia with bifacial paralysis, and may be accompanied by Pseudobulbar behavioral symptoms such as enforced crying and laughing.	MSH:D020828|SNOMEDCT_US:7379000|UMLS:C0033790	hp.json	Pseudobulbar syndrome|Pseudobulbar palsy	http://purl.obolibrary.org/obo/HP_0007024		
GO:0001936	biolink:BiologicalProcess	regulation of endothelial cell proliferation	Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0001936		
GO:0001937	biolink:BiologicalProcess	negative regulation of endothelial cell proliferation	Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.		hp.json	downregulation of endothelial cell proliferation|down regulation of endothelial cell proliferation|inhibition of endothelial cell proliferation|down-regulation of endothelial cell proliferation	http://purl.obolibrary.org/obo/GO_0001937		
HP:0009686	biolink:PhenotypicFeature	Absent epiphyses of the thumb	Absence of one or more epiphyses of the thumb.	UMLS:C4024233	hp.json		http://purl.obolibrary.org/obo/HP_0009686		
GO:0001938	biolink:BiologicalProcess	positive regulation of endothelial cell proliferation	Any process that activates or increases the rate or extent of endothelial cell proliferation.		hp.json	up regulation of endothelial cell proliferation|stimulation of endothelial cell proliferation|up-regulation of endothelial cell proliferation|activation of endothelial cell proliferation|upregulation of endothelial cell proliferation	http://purl.obolibrary.org/obo/GO_0001938		
HP:0009689	biolink:PhenotypicFeature	Enlarged thumb epiphysis	Abnormally large size of the epiphyses of the thumb with respect to age-dependent norms.	UMLS:C4021406	hp.json	Enlarged epiphyses of the thumb|Enlarged end part of thumb long bone	http://purl.obolibrary.org/obo/HP_0009689		
HP:0009688	biolink:PhenotypicFeature	Cone-shaped epiphysis of the thumb	A cone-shaped appearance of the epiphyses of the thumb, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.	UMLS:C4021407	hp.json	Cone-shaped end part of thumb long bone|Cone-shaped epiphyses of the thumb|Cone-shaped thumb epiphyses	http://purl.obolibrary.org/obo/HP_0009688		
HP:0007027	biolink:PhenotypicFeature	Poorly formed metencephalon	A morphological abnormality of the metencephalon.	UMLS:C4024951	hp.json		http://purl.obolibrary.org/obo/HP_0007027		
HP:0009683	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the thumb	Abnormally small size of the epiphysis located at the proximal end of the distal phalanx of the thumb with respect to age-dependent norms.	UMLS:C4024236	hp.json	Small end part of thumb outermost bone	http://purl.obolibrary.org/obo/HP_0009683		
HP:0007020	biolink:PhenotypicFeature	Progressive spastic paraplegia		UMLS:C1855483	hp.json		http://purl.obolibrary.org/obo/HP_0007020		
HP:0009682	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the thumb	A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of the distal phalanx of the thumb.	UMLS:C4024237	hp.json	Pseudoepiphysis of the outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009682		
HP:0007021	biolink:PhenotypicFeature	Pain insensitivity	Inability to perceive painful stimuli.	UMLS:C0344307|SNOMEDCT_US:38433004	hp.json	Absence of pain sensation	http://purl.obolibrary.org/obo/HP_0007021		
UBERON:0000220	biolink:AnatomicalEntity	atlanto-occipital joint	The Atlanto-occipital joint (articulation between the atlas and the occipital bone) consists of a pair of condyloid joints. The atlanto-occipital joint is a synovial joint. The ligaments connecting the bones are: Two Articular capsules; Posterior atlantoöccipital membrane; Anterior atlantoöccipital membrane; Lateral atlantoöccipital.	FMA:24939|NCIT:C32158|ncithesaurus:Atlanto-occipital_Joint-Atlanto|MESH:D001269|UMLS:C0004169	hp.json	occipito-atlantal joint|articulatio atlanto-occipitalis|craniovertebral joint|articulatio atlantooccipitalis|atlanto occipital joint|atlantooccipital joint|occipito atlantal joint	http://purl.obolibrary.org/obo/UBERON_0000220		
HP:0009685	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the thumb	A triangular appearance of the epiphysis of the distal phalanx of the thumb of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat.	UMLS:C4024234	hp.json	Triangular epiphysis of the outermost bone of the thumb|Triangular end part of thumb outermost bone	http://purl.obolibrary.org/obo/HP_0009685		
HP:0009684	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the thumb	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the thumb.	UMLS:C4024235	hp.json	Speckled calcifications in the end part of the outermost thumb bone	http://purl.obolibrary.org/obo/HP_0009684		
GO:0001935	biolink:BiologicalProcess	endothelial cell proliferation	The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.		hp.json		http://purl.obolibrary.org/obo/GO_0001935		
HP:0007023	biolink:PhenotypicFeature	Antenatal intracerebral hemorrhage	Cerebral hemorrhage that occurs before birth.	UMLS:C1837247	hp.json	Antenatal intracerebral haemorrhage	http://purl.obolibrary.org/obo/HP_0007023		
CHEBI:50402	biolink:ChemicalSubstance	androstanoid	Any steroid based on an  androstane skeleton and its derivatives.		hp.json	androstanoids	http://purl.obolibrary.org/obo/CHEBI_50402		3_STAR
UBERON:0000209	biolink:AnatomicalEntity	tetrapod frontal bone	The bone forming the forehead and roof of the eye orbit.	UMLS:C0016732|VHOG:0001324|GAID:226|NCIT:C32635|AAO:0000206|EMAPA:19016|MA:0001466|FMA:52734|VSAO:0000208|MESH:D005624	hp.json	frontal bone|frontal|os frontal|os frontale|frontal bone	http://purl.obolibrary.org/obo/UBERON_0000209		pheno_slim
CHEBI:50401	biolink:ChemicalSubstance	cholestanoid	Any steroid based on a cholestane skeleton and its derivatives.		hp.json	cholestanoids	http://purl.obolibrary.org/obo/CHEBI_50401		3_STAR
HP:0007041	biolink:PhenotypicFeature	Chronic lymphocytic meningitis	Meningitis that persists for more than 4 weeks, and lymphocytes are present in the cerebrospinal fluid (CSF).	SNOMEDCT_US:230154004|UMLS:C0393441	hp.json		http://purl.obolibrary.org/obo/HP_0007041		
UBERON:0000204	biolink:AnatomicalEntity	ventral part of telencephalon	Ventral part (base region) of the telencephalon.	EFO:0003522|BTO:0003401|ZFA:0000304|TAO:0000304|DMBA:15751	hp.json	subpallium|area ventralis telencephali|ventral telencephalon|subpallium	http://purl.obolibrary.org/obo/UBERON_0000204		efo_slim|developmental_classification
CHEBI:50404	biolink:ChemicalSubstance	lipoprotein cholesterol	Cholesterol esters and free cholesterol which are contained in or bound to lipoproteins.		hp.json		http://purl.obolibrary.org/obo/CHEBI_50404		3_STAR
HP:0010676	biolink:PhenotypicFeature	Mechanical ileus		UMLS:C0400843|SNOMEDCT_US:46420000	hp.json		http://purl.obolibrary.org/obo/HP_0010676		
UBERON:0014852	biolink:AnatomicalEntity	chorda tendinea of right ventricle	Chorda tendinea which is attached to the leaflet of tricuspid valve and is continuous with the endocardium of papillary muscle of right ventricle.	FMA:9300	hp.json		http://purl.obolibrary.org/obo/UBERON_0014852		pheno_slim
HP:0032002	biolink:PhenotypicFeature	Orange urine	An abnormal orange color of urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032002		
HP:0010675	biolink:PhenotypicFeature	Abnormal foot bone ossification	An abnormality of the formation and mineralization of any bone of the skeleton of foot.	UMLS:C4021241|UMLS:C4020768|UMLS:C4280367	hp.json	Abnormal maturation of foot bones|Abnormality of the mineralisation and ossification of bones of the feet|Abnormal ossification involving bones of the feet	http://purl.obolibrary.org/obo/HP_0010675		
HP:0032003	biolink:PhenotypicFeature	Green urine	An abnormal green color of urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032003		
HP:0010674	biolink:PhenotypicFeature	Abnormality of the curvature of the vertebral column	The presence of an abnormal curvature of the vertebral column.	UMLS:C4023747	hp.json	Abnormal curve of the spine|Curvature of spine|Curved spine|Abnormal curving of the spine|Abnormal curve of the backbone	http://purl.obolibrary.org/obo/HP_0010674		
HP:0032004	biolink:PhenotypicFeature	Pruritus vulvae	A sensation of itching in the vulvar region.		hp.json		http://purl.obolibrary.org/obo/HP_0032004		
HP:0032005	biolink:PhenotypicFeature	Hemidystonia	Hemidystonia refers to dystonia which involves the ipsilateral face, arm, and leg.		hp.json		http://purl.obolibrary.org/obo/HP_0032005		
HP:0010672	biolink:PhenotypicFeature	Abnormality of the third metatarsal bone	An abnormality of the third metatarsal bone.	UMLS:C4023748	hp.json	Abnormality of the 3rd long bone of foot	http://purl.obolibrary.org/obo/HP_0010672		
HP:0032000	biolink:PhenotypicFeature	Pleural rub	An abnormal breath sound that is nonmusical, short and explosive. It is grating, rubbing, creaky, or leathery in character and present in both phases of respiration. Typically the expiratory component mirrors the inspiratory component. It occurs due to inflamed pleural surface rubbing each other during breathing. Clinically, it is important to differentiate it from crackles		hp.json		http://purl.obolibrary.org/obo/HP_0032000		
HP:0032001	biolink:PhenotypicFeature	Pink urine	An abnormal pink color of urine.		hp.json		http://purl.obolibrary.org/obo/HP_0032001		
UBERON:0014851	biolink:AnatomicalEntity	chorda tendinea of left ventricle	Chorda tendinea which is attached to the leaflet of mitral valve and is continuous with the endocardium of papillary muscle of left ventricle.	FMA:9349	hp.json		http://purl.obolibrary.org/obo/UBERON_0014851		pheno_slim
CHEBI:37445	biolink:ChemicalSubstance	folic acids	A group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid units.		hp.json	folate|folates|folates	http://purl.obolibrary.org/obo/CHEBI_37445		3_STAR
HP:0032006	biolink:PhenotypicFeature	Lip tremor	An unintentional, oscillating to-and-fro muscle movement affecting the lip.		hp.json		http://purl.obolibrary.org/obo/HP_0032006		
HP:0007039	biolink:PhenotypicFeature	Symmetric lesions of the basal ganglia		UMLS:C4024947	hp.json		http://purl.obolibrary.org/obo/HP_0007039		
HP:0032007	biolink:PhenotypicFeature	Maceration	A softening and breaking down of skin resulting from prolonged exposure to moisture. Macerated skin becomes soft and wrinkly and takes on a whitish hue.		hp.json	Maceration of the skin|Skin maceration	http://purl.obolibrary.org/obo/HP_0032007		
HP:0010679	biolink:PhenotypicFeature	Elevated tissue non-specific alkaline phosphatase	An abnormally increased level of alkaline phosphatase, tissue-nonspecific isozyme in the blood.	UMLS:C4021240	hp.json	Elevated tissue non-specific ALP|Elevated alkaline phosphatase, liver/bone/kidney	http://purl.obolibrary.org/obo/HP_0010679		
UBERON:0014847	biolink:AnatomicalEntity	vastus intermedius	The Vastus intermedius (Cruraeus) arises from the front and lateral surfaces of the body of the femur in its upper two-thirds, sitting under Rectus Femoris and from the lower part of the lateral intermuscular septum. Its fibers end in a superficial aponeurosis, which forms the deep part of the Quadriceps femoris tendon. The Vastus medialis and Vastus intermedius appear to be inseparably united, but when the Rectus femoris has been reflected a narrow interval will be observed extending upward from the medial border of the patella between the two muscles, and the separation may be continued as far as the lower part of the intertrochanteric line, where, however, the two muscles are frequently continuous.	FMA:22433|BTO:0002542|EMAPA:36243	hp.json	intermediate vastus muscle|vastus intermedialis|intermediate great muscle|vastus intermedius|crureus|cruraeus|musculus vastus intermedius	http://purl.obolibrary.org/obo/UBERON_0014847		
HP:0032008	biolink:PhenotypicFeature	Pulmonary fat embolism	The release of fat globules into the venous circulation, thereby blocking blood circulation to the lung.		hp.json	Fat embolism	http://purl.obolibrary.org/obo/HP_0032008		
HP:0010678	biolink:PhenotypicFeature	Enuresis diurna	Enuresis occurring during waking hours of the day.	UMLS:C4023746	hp.json		http://purl.obolibrary.org/obo/HP_0010678		
UBERON:0014848	biolink:AnatomicalEntity	tendon of quadriceps femoris		FMA:46900	hp.json	common quadriceps femoris tendon|common tendon of quadriceps femoris muscle complex|common quadriceps tendon|quadriceps femoris tendon|common tendon of quadriceps femoris|quadriceps tendon	http://purl.obolibrary.org/obo/UBERON_0014848		human_reference_atlas
HP:0032009	biolink:PhenotypicFeature	Infantile constant exotropia	Constant exotropia occurring before 6 months of age.; often associated with a large angle of deviation and ocular/CNS abnormalities.		hp.json	Infantile (constant) exotropia	http://purl.obolibrary.org/obo/HP_0032009		
HP:0010677	biolink:PhenotypicFeature	Enuresis nocturna	Enuresis occurring during sleeping hours.	MSH:D053206|UMLS:C0270327|SNOMEDCT_US:8009008	hp.json	Nocturnal enuresis	http://purl.obolibrary.org/obo/HP_0010677		
UBERON:0000211	biolink:AnatomicalEntity	ligament	Dense regular connective tissue connecting two or more adjacent skeletal elements or supporting an organ.	OpenCyc:Mx4rvVjqpZwpEbGdrcN5Y29ycA|FMA:21496|UMLS:C0023685|MESH:D008022|CALOHA:TS-2145|FMA:30319|ZFA:0001675|MA:0000113|VHOG:0001272|EFO:0001966|EMAPA:35493|TAO:0001682|NCIT:C13046|XAO:0004031|galen:Ligament	hp.json	ligament organ	http://purl.obolibrary.org/obo/UBERON_0000211		uberon_slim|vertebrate_core|pheno_slim|efo_slim
HP:0007035	biolink:PhenotypicFeature	Anterior encephalocele		UMLS:C4024948	hp.json		http://purl.obolibrary.org/obo/HP_0007035		
HP:0009697	biolink:PhenotypicFeature	Contracture of the distal interphalangeal joint of the fingers	Chronic loss of joint motion in one or more distal interphalangeal joints of the fingers.	UMLS:C4024230	hp.json		http://purl.obolibrary.org/obo/HP_0009697		
HP:0007036	biolink:PhenotypicFeature	Hypoplasia of olfactory tract		UMLS:C1856655	hp.json	Underdeveloped olfactory tract	http://purl.obolibrary.org/obo/HP_0007036		
HP:0009699	biolink:PhenotypicFeature	Osteolytic defects of the hand bones		UMLS:C4021400	hp.json	Lytic defects of hand bones	http://purl.obolibrary.org/obo/HP_0009699		
HP:0009694	biolink:PhenotypicFeature	Small thumb epiphysis	Abnormally small size of one or more of the epiphyses of the thumb with respect to age-dependent norms.	UMLS:C4021402	hp.json	Small end part of thumb long bone|Small epiphyses of the thumb	http://purl.obolibrary.org/obo/HP_0009694		
HP:0009693	biolink:PhenotypicFeature	Pseudoepiphysis of the thumb	A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of one or more phalanges of the thumb.	UMLS:C3552484	hp.json	Pseudoepiphyses of the thumb	http://purl.obolibrary.org/obo/HP_0009693		
GO:0001944	biolink:BiologicalProcess	vasculature development	The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.		hp.json	vascular system development	http://purl.obolibrary.org/obo/GO_0001944		
HP:0007033	biolink:PhenotypicFeature	Cerebellar dysplasia	Cerebellar dysplasia (abnormal growth or development) is defined by abnormal cerebellar foliation, white matter arborization, and gray-white matter junction. Cerebellar dysplasia is a neuroimaging finding that describes abnormalities of both the cerebellar cortex and white matter and is associated with variable neurodevelopmental outcome. Dysplasia may globally involve the cerebellum or affect only one cerebellar hemisphere. In addition, cerebellar dysplasia may be associated with cortical/subcortical cysts.	UMLS:C3278322	hp.json		http://purl.obolibrary.org/obo/HP_0007033		
HP:0009696	biolink:PhenotypicFeature	Triangular epiphyses of the thumb		UMLS:C4024231	hp.json	Triangular end part of the thumb bone	http://purl.obolibrary.org/obo/HP_0009696		
UBERON:0002871	biolink:AnatomicalEntity	hypoglossal nucleus	Nucleus forming a longitudinal cell column in the medulla, close beneath the floor of the 4th ventricle, containing motor neurons that innervate the muscles of the tongue (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 453).	HBA:9557|MA:0001039|NCIT:C12899|DHBA:12545|FMA:54505|EHDAA2:0004635|ncithesaurus:Nucleus_of_the_Hypoglossal_Nerve|BM:XII|BAMS:12N|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=757|UMLS:C0228802|EMAPA:35416|BAMS:12|Wikipedia:Hypoglossal_nucleus|EV:0100286|UMLS:C0228802|SCTID:47361005|MBA:773|VHOG:0001358|BAMS:XII|BIRNLEX:2644	hp.json	hypoglossal XII nucleus|nucleus nervi hypoglossi|hypoglossal nucleus|nucleus nervi hypoglossi|twelfth cranial nerve nucleus|nucleus nervi hypoglossi|nucleus of hypoglossal nerve|hypoglossal nerve nucleus|nucleus hypoglossalis	http://purl.obolibrary.org/obo/UBERON_0002871		uberon_slim|pheno_slim
HP:0007034	biolink:PhenotypicFeature	Generalized hyperreflexia		UMLS:C4024949	hp.json	Generalised hyperreflexia	http://purl.obolibrary.org/obo/HP_0007034		
UBERON:0000210	biolink:AnatomicalEntity	tetrapod parietal bone	In humans: bone forming side and roof of cranium. Each bone is irregularly quadrilateral in form, and has two surfaces, four borders, and four angles.	MA:0001469|FMA:9613|AAO:0000390|NCIT:C12766|UMLS:C0030558|VHOG:0001326|MESH:D010294|GAID:229|EMAPA:18715|VHOG:0001324	hp.json	parietal bone|parietal|actinopterygian frontal bone|os parietale|frontal bone|os parietale	http://purl.obolibrary.org/obo/UBERON_0000210		pheno_slim
HP:0009695	biolink:PhenotypicFeature	Stippling of thumb epiphysis	The presence of abnormal punctate (speckled, dot-like) calcifications in one or more of the epiphyses of the thumb.	UMLS:C4021401	hp.json	Stippling of the epiphyses of the thumb|Speckled calcifications in end part of thumb bone	http://purl.obolibrary.org/obo/HP_0009695		
HP:0009670	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the thumb	Sclerosis of the epiphysis of the proximal phalanx of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024247	hp.json	Increased bone density of end part of the innermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009670		
NCBITaxon:35493	biolink:OrganismalEntity	Streptophyta		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_35493		
HP:0010665	biolink:PhenotypicFeature	Bilateral coxa valga	The presence of bilateral coxa valga.	UMLS:C3810018	hp.json		http://purl.obolibrary.org/obo/HP_0010665		
HP:0032013	biolink:PhenotypicFeature	Hypermetric horizontal saccades	Overshoot of horizontal (sideways) saccadic eye movements.		hp.json		http://purl.obolibrary.org/obo/HP_0032013		
HP:0010664	biolink:PhenotypicFeature	Fusion of the left and right thalami	A developmental defect characterized by fusion of the left and right halves of the thalamus.	UMLS:C4020769|UMLS:C1834930	hp.json	Fusion of thamali|Fused thalami|Undivided thalami	http://purl.obolibrary.org/obo/HP_0010664		
HP:0032014	biolink:PhenotypicFeature	Dysmetric vertical saccades	Inaccurate saccades (rapid movement of the eye between fixation points) in the vertical direction.		hp.json		http://purl.obolibrary.org/obo/HP_0032014		
HP:0010663	biolink:PhenotypicFeature	Abnormality of thalamus morphology	An abnormality of the thalamus.	UMLS:C4021243	hp.json	Abnormality of the thalamus|Abnormal shape of thalamus	http://purl.obolibrary.org/obo/HP_0010663		
HP:0032015	biolink:PhenotypicFeature	Dysmetric horizontal saccades	Inaccurate saccades (rapid movement of the eye between fixation points) in the horizontal direction.		hp.json		http://purl.obolibrary.org/obo/HP_0032015		
HP:0010662	biolink:PhenotypicFeature	Abnormality of the diencephalon	An abnormality of the Diencephalon, which together with the cerebrum (telencephalon) makes up the forebrain.	UMLS:C4023752	hp.json		http://purl.obolibrary.org/obo/HP_0010662		
HP:0032016	biolink:PhenotypicFeature	Abnormal sputum	Abnormal appearance of material expectorated (coughed up) from the respiratory system and that is composed of mucus but may contain other substances such as pus, blood, microorganisms, and fibrin.		hp.json	Abnormal sputum morphology	http://purl.obolibrary.org/obo/HP_0032016		
HP:0010661	biolink:PhenotypicFeature	Absence of the third cerebral ventricle	A developmental defect characterized by the absence of the third ventricle.	UMLS:C4023753	hp.json		http://purl.obolibrary.org/obo/HP_0010661		
HP:0032010	biolink:PhenotypicFeature	Basic constant exotropia	Constant exotropia for near and distance, presenting after 6 months of age.		hp.json	Basic (constant) exotropia	http://purl.obolibrary.org/obo/HP_0032010		
HP:0010660	biolink:PhenotypicFeature	Abnormal hand bone ossification	An abnormality of the formation and mineralization of any bone of the skeleton of hand.	UMLS:C4021244	hp.json	Abnormal maturation of the hand bones|Abnormality of the mineralisation and ossification of bones of the hand|Abnormal ossification of hand bones	http://purl.obolibrary.org/obo/HP_0010660		
HP:0032011	biolink:PhenotypicFeature	Heterophoria	Heterophorias are latent deviations that are controlled by fusion. In certain circumstances (specific visual tasks, fatigue, illness, etc.), fusion can no longer be maintained and decompensation occurs.		hp.json		http://purl.obolibrary.org/obo/HP_0032011		
HP:0032012	biolink:PhenotypicFeature	Heterotropia	Manifest deviation of the visual axes not controlled by fusion.		hp.json		http://purl.obolibrary.org/obo/HP_0032012		
HP:0010669	biolink:PhenotypicFeature	Hypoplasia of the zygomatic bone	Underdevelopment of the zygomatic bone. That is, a reduction in size of the zygomatic bone, including the zygomatic process of the temporal bone of the skull, which forms part of the zygomatic arch.	UMLS:C4280370|UMLS:C4021242|UMLS:C4072879|UMLS:C4280369|UMLS:C4280368	hp.json	Small malar bone|Cheekbone underdevelopment|Decreased size of zygomatic bone|Hypotrophy of the zygomatic bone|Depressed zygomatic bone|Small cheekbone|Decreased size of cheekbone|Depressed cheekbone|Underdevelopment of zygomatic bone|Hypotrophy of the cheekbone|Small zygomatic bone|Underdevelopment of cheekbone|Hypoplasia of cheekbone|Flattening of the zygomatic bone|Hypotrophic zygomatic bone|Hypotrophic cheekbone	http://purl.obolibrary.org/obo/HP_0010669		
HP:0007006	biolink:PhenotypicFeature	Dorsal column degeneration		UMLS:C4024953	hp.json		http://purl.obolibrary.org/obo/HP_0007006		
HP:0009669	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the thumb	Irregular radiographic opacity of the epiphysis of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024248	hp.json	Irregular end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009669		
HP:0032017	biolink:PhenotypicFeature	Sputum eosinophilia	An increased proportion of eosinophils in sputum in the differentiated cell count.		hp.json		http://purl.obolibrary.org/obo/HP_0032017		
HP:0010668	biolink:PhenotypicFeature	Abnormal zygomatic bone morphology	An abnormality of the zygomatic bone.	UMLS:C4023749	hp.json	Deformity of the zygomatic bone|Malformation of the zygomatic bone|Abnormality of the zygomatic bone|Anomaly of the zygomatic bone|Abnormal malar bone morphology|Deformity of the cheekbone|Abnormality of the cheekbone	http://purl.obolibrary.org/obo/HP_0010668		
HP:0007007	biolink:PhenotypicFeature	Cavitation of the basal ganglia	The formation of small cavities in the tissue of the basal ganglia.	UMLS:C4024952	hp.json		http://purl.obolibrary.org/obo/HP_0007007		
HP:0009668	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the thumb	Epiphysis of the proximal phalanx of the thumb having multiple bony fragments.	UMLS:C4024249	hp.json	Fragmentation of end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009668		
HP:0032018	biolink:PhenotypicFeature	Multiple mononeuropathy	A type of peripheral neuropathy that happens when there is damage to two or more different nerve areas characterized by peripheral neuropathy of both the motor and sensory nerves of at least two different nerve trunks. Different nerves are affected either simultaneously or sequentially.		hp.json	Mononeuritis multiplex	http://purl.obolibrary.org/obo/HP_0032018		
HP:0010667	biolink:PhenotypicFeature	Aplasia of the maxilla	A congenital defect characterized by absence of the Maxilla.	UMLS:C4280371|UMLS:C4023750	hp.json	Absence of the maxilla|Failure of development of upper jaw bones|Aplasia of the upper jaw bones|Agenesis of the maxilla|Missing upper jaw bones|Failure of development of maxilla|Absence of upper jaw bones	http://purl.obolibrary.org/obo/HP_0010667		
HP:0032019	biolink:PhenotypicFeature	Muscle eosinophilia	Eosinophil infiltration of skeletal muscle.		hp.json	Eosinophilic infiltration of skeletal muscle	http://purl.obolibrary.org/obo/HP_0032019		
HP:0010666	biolink:PhenotypicFeature	Hypoplasia of the anterior nasal spine	Underdevelopment of the anterior nasal spine of maxilla.	UMLS:C4023751|UMLS:C4280373|UMLS:C4280372	hp.json	Decreased length of anterior nasal spine|Deficiency of anterior nasal spine|Underdevelopment of anterior nasal spine|Small anterior nasal spine|Hypotrophic anterior nasal spine|Decreased size of anterior nasal spine|Decreased projection of anterior nasal spine	http://purl.obolibrary.org/obo/HP_0010666		
HP:0007009	biolink:PhenotypicFeature	Central nervous system degeneration		UMLS:C3277687	hp.json	CNS degeneration	http://purl.obolibrary.org/obo/HP_0007009		
UBERON:0000200	biolink:AnatomicalEntity	gyrus	A ridge on the cerebral cortex. It is generally surrounded by one or more sulci .	BTO:0002495|NCIT:C32290|FMA:83874|UMLS:C0458308	hp.json	gyri|gyrus of neuraxis|gyrus of cerebral hemisphere|gyrus of cerebrum|cerebral gyrus|folia|folium|gyri of cerebrum|neuraxis gyrus|folium of brain	http://purl.obolibrary.org/obo/UBERON_0000200		pheno_slim
HP:0009665	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the thumb	An abnormality of the proximal phalanx of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024252	hp.json	Bracket shaped end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009665		
HP:0007002	biolink:PhenotypicFeature	Motor axonal neuropathy	Progressive impairment of function of motor axons with muscle weakness, atrophy, and cramps. The deficits are length-dependent, meaning that muscles innervated by the longest nerves are affected first, so that for instance the arms are affected at a later age than the onset of deficits involving the lower leg.	UMLS:C1854570|UMLS:C2749625|UMLS:C4020811	hp.json	Distal motor neuropathy|Length dependent motor neuropathy	http://purl.obolibrary.org/obo/HP_0007002		
HP:0009664	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the thumb	Absence of the epiphysis located at the proximal end of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024253	hp.json	Absent end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009664		
HP:0009667	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the thumb	Abnormally large size of the epiphysis located at the proximal end of the proximal phalanx of the thumb with respect to age-dependent norms. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024250	hp.json	Enlarged end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009667		
UBERON:0000203	biolink:AnatomicalEntity	pallium	Dorsal part (roof region) of the telencephalon[GO].	DMBA:15903|ZFA:0000505|Wikipedia:Pallium_(neuroanatomy)|BTO:0003399|TAO:0000505|Wikipedia:Avian_pallium|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3240|TAO:0007007|EFO:0003534|SCTID:369224000	hp.json	dorsal telencephalic area|dorsal telencephalon|dorsal part of telencephalon|area dorsalis telencephali	http://purl.obolibrary.org/obo/UBERON_0000203		developmental_classification|efo_slim
HP:0009666	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the thumb	A cone-shaped appearance of the epiphysis of the proximal phalanx of the thumb of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024251	hp.json	Cone-shaped end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009666		
GO:0001910	biolink:BiologicalProcess	regulation of leukocyte mediated cytotoxicity	Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.		hp.json	regulation of immune cell mediated cytotoxicity|regulation of leucocyte mediated cytotoxicity|regulation of immune cell mediated cell death|regulation of immune cell mediated cell killing	http://purl.obolibrary.org/obo/GO_0001910		
HP:0009660	biolink:PhenotypicFeature	Short phalanx of the thumb	Hypoplastic (short) thumb phalanx.	UMLS:C4021411	hp.json	Hypoplastic/small phalanges of the thumb|Hypoplastic thumb phalanges|Short thumb bone|Short thumb phalanges	http://purl.obolibrary.org/obo/HP_0009660		
GO:0001911	biolink:BiologicalProcess	negative regulation of leukocyte mediated cytotoxicity	Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.		hp.json	down-regulation of leukocyte mediated cytotoxicity|down regulation of leukocyte mediated cytotoxicity|downregulation of leukocyte mediated cytotoxicity|inhibition of leukocyte mediated cytotoxicity|negative regulation of immune cell mediated cytotoxicity|negative regulation of leucocyte mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0001911		
HP:0007000	biolink:PhenotypicFeature	Morning myoclonic jerks		UMLS:C1847164	hp.json		http://purl.obolibrary.org/obo/HP_0007000		
HP:0009663	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the thumb	This term applies if the epiphysis of the proximal phalanx of the thumb, which is located at the proximal end of the phalanx, does not appear in concordance with gender and age dependant norms as seen on x-rays. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024254	hp.json	Abnormality of end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009663		
GO:0001912	biolink:BiologicalProcess	positive regulation of leukocyte mediated cytotoxicity	Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.		hp.json	activation of leukocyte mediated cytotoxicity|stimulation of leukocyte mediated cytotoxicity|upregulation of leukocyte mediated cytotoxicity|positive regulation of immune cell mediated cytotoxicity|positive regulation of leucocyte mediated cytotoxicity|up-regulation of leukocyte mediated cytotoxicity|up regulation of leukocyte mediated cytotoxicity	http://purl.obolibrary.org/obo/GO_0001912		
HP:0009662	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the thumb	Abnormality of the epiphysis of the distal phalanx of the thumb. This epiphysis is located on the proximal end of the phalanx.	UMLS:C4021410	hp.json	Abnormality of the end part of the outermost bone of the thumb|Abnormality of terminal thumb epiphysis	http://purl.obolibrary.org/obo/HP_0009662		
HP:0007001	biolink:PhenotypicFeature	Loss of Purkinje cells in the cerebellar vermis		UMLS:C1849146	hp.json		http://purl.obolibrary.org/obo/HP_0007001		
HP:0009681	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the thumb	Sclerosis of the epiphysis of the distal phalanx of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4024238	hp.json	Increased bone density of end part of the outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009681		
HP:0009680	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the thumb	Uneven radiographic opacity of the epiphysis of the distal phalanx of the thumb.	UMLS:C4024239	hp.json	Irregular end part of thumb outermost bone	http://purl.obolibrary.org/obo/HP_0009680		
HP:0032024	biolink:PhenotypicFeature	Ileal ulcer	An erosion of the mucous membrane in a portion of the ileum.		hp.json		http://purl.obolibrary.org/obo/HP_0032024		
HP:0010654	biolink:PhenotypicFeature	Aplasia of the falx cerebri	A developmental defect characterized by aplasia of the Falx cerebri.	UMLS:C4023756	hp.json	Absent cerebral falx	http://purl.obolibrary.org/obo/HP_0010654		
HP:0032025	biolink:PhenotypicFeature	Reduced serum alpha-1-antitrypsin	A reduced concentration of circulating alpha-1 antitrypsin, which is a 52-kDa glycoprotein mainly synthesised and secreted by hepatocytes into the bloodstream. Alpha-1 antitrypsin is a serine-proteinase inhibitor that it is crucial in maintaining protease-antiprotease homeostasis in the lungs.		hp.json		http://purl.obolibrary.org/obo/HP_0032025		
HP:0010653	biolink:PhenotypicFeature	Abnormality of the falx cerebri	An abnormality of the Falx cerebri.	UMLS:C4021247	hp.json	Abnormality of the cerebral falx	http://purl.obolibrary.org/obo/HP_0010653		
HP:0010652	biolink:PhenotypicFeature	Abnormal dura mater morphology	An abnormality of the Dura mater.	UMLS:C4023757	hp.json	Abnormality of the dura mater	http://purl.obolibrary.org/obo/HP_0010652		
HP:0032026	biolink:PhenotypicFeature	Anetoderma	Circumscribed area of flaccid skin due to the loss of elastic tissue in the dermis.		hp.json		http://purl.obolibrary.org/obo/HP_0032026		
HP:0032027	biolink:PhenotypicFeature	Retinal dots	Yellow, white or greyish lesions in the retina that are well-defined/distinct, individual and mostly uniform in size.		hp.json		http://purl.obolibrary.org/obo/HP_0032027		
HP:0010651	biolink:PhenotypicFeature	Abnormal meningeal morphology	An abnormality of the Meninges, including any abnormality of the Dura mater, the Arachnoid mater, and the Pia mater.	UMLS:C4023758	hp.json	Abnormality of the meninges	http://purl.obolibrary.org/obo/HP_0010651		
HP:0010650	biolink:PhenotypicFeature	Hypoplasia of the premaxilla	An abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively small in size compared to the other parts of the maxilla or other facial structures.	UMLS:C4020770|UMLS:C4072878	hp.json	Underdevelopment of premaxilla|Small primary palate bone|Premaxillary bone deficiency|Premaxillary retrusion|Underdevelopment of the premaxilla|Primary palate bone retrusion|Underdevelopment of the primary palate bone|Small premaxilla|Hypoplasia of the intermaxillary bone|Hypoplasia of the primary palate bone|Decreased size of premaxilla|Decreased size of the primary palate bone|Premaxillary bone retrusion|Primary palate bone deficiency|Premaxillary underdevelopment	http://purl.obolibrary.org/obo/HP_0010650		hposlim_core
HP:0032020	biolink:PhenotypicFeature	Eosinophilic bladder infiltration	Transmural inflammation of the bladder predominantly with eosinophils, associated with fibrosis with or without muscle necrosis.		hp.json	Eosinophilic cystitis	http://purl.obolibrary.org/obo/HP_0032020		
HP:0032021	biolink:PhenotypicFeature	Eosinophilic liver infiltration	Cellular infiltration of the liver parenchyma with a preponderance of eosinophils.		hp.json	Eosinophilic hepatitis	http://purl.obolibrary.org/obo/HP_0032021		
HP:0032022	biolink:PhenotypicFeature	Eosinophilic dermal infiltration	Presence of abnormally increased amounts of intraepidermal inflammatory cells with a predominance of eosinophils.		hp.json	Eosinophilic dermatitis	http://purl.obolibrary.org/obo/HP_0032022		
HP:0032023	biolink:PhenotypicFeature	Eosinophilic gallbladder infiltration	Cellular infiltrate confirmed by a cellular infiltrate comprised of mainly eosinophils in the gallbladder wall on histological examination.		hp.json	Eosinophilic cholecystitis	http://purl.obolibrary.org/obo/HP_0032023		
HP:0010659	biolink:PhenotypicFeature	Patchy variation in bone mineral density	Patchy (irregular) changes in bone mineral density with patches of bone showing an increased density side to side with patches that are affected by reduction of mineral density. This is sometimes referred to as a moth-eaten appearance on x-rays.	UMLS:C4021245	hp.json	Patchy increased and decreased bone mineral density	http://purl.obolibrary.org/obo/HP_0010659		
HP:0010658	biolink:PhenotypicFeature	Patchy changes of bone mineral density	Patchy (irregular) changes in bone mineral density. These changes can either be patchy reduction or increase of mineral density as seen on x-rays. Depending on the pathomechanism and the underlying disease, these changes can either appear solely as reduction or increase or as a combination of both (patches of bone showing an increased density while others are affected by reduction of mineral density).	UMLS:C4023754	hp.json		http://purl.obolibrary.org/obo/HP_0010658		
HP:0032028	biolink:PhenotypicFeature	Macular dots	Yellow, white or greyish lesions in the macula that are well-defined/distinct, individual and mostly uniform in size.		hp.json		http://purl.obolibrary.org/obo/HP_0032028		
HP:0007017	biolink:PhenotypicFeature	Progressive forgetfulness		UMLS:C3277688	hp.json	Forgetfullness	http://purl.obolibrary.org/obo/HP_0007017		
HP:0010657	biolink:PhenotypicFeature	Patchy reduction of bone mineral density	Patchy (irregular) reduction in bone density. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4023755	hp.json		http://purl.obolibrary.org/obo/HP_0010657		
HP:0009679	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the thumb	Epiphysis of the distal phalanx of the thumb having multiple bony fragments.	UMLS:C4024240	hp.json	Fragmentation of end part thumb outermost long bone	http://purl.obolibrary.org/obo/HP_0009679		
HP:0007018	biolink:PhenotypicFeature	Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient.	SNOMEDCT_US:7461003|UMLS:C1263846|SNOMEDCT_US:406506008|MSH:D001289	hp.json	Attention deficits|Attention deficit-hyperactivity disorder|Attention deficit|Attention deficit disorder|Childhood attention deficit/hyperactivity disorder|ADHD	http://purl.obolibrary.org/obo/HP_0007018		
HP:0032029	biolink:PhenotypicFeature	Floppy eyelid	Excessive eyelid tissue laxity, typically affecting both upper eyelids and associated with spontanteous tarsal eversion during sleep. It is more common in the obese, it may be associated with obstructive sleep apnea and it may result in corneal exposure or chronic papillary conjunctivitis.		hp.json		http://purl.obolibrary.org/obo/HP_0032029		
HP:0010656	biolink:PhenotypicFeature	Abnormal epiphyseal ossification	An abnormality of the formation and mineralization of an epiphysis.	UMLS:C4021246	hp.json	Abnormal maturation of the end part of a bone|Abnormality of the mineralisation or ossification of the epiphyses	http://purl.obolibrary.org/obo/HP_0010656		
HP:0010655	biolink:PhenotypicFeature	Epiphyseal stippling	The presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses.	SNOMEDCT_US:360507004|UMLS:C1859126	hp.json	Stippled epiphyses|Stippling of the epiphyses|Speckled calcifications in end part of bone|Epiphyseal punctate calcifications	http://purl.obolibrary.org/obo/HP_0010655		
HP:0009676	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the thumb	An abnormality of the distal phalanx of the thumb in which the epiphysis surrounds a phalangeal bone, having a bracket-like form and reaching from the proximal side of a phalanx to the distal side.	UMLS:C4024241	hp.json	Bracket shaped end part of thumb outermost long bone	http://purl.obolibrary.org/obo/HP_0009676		
HP:0009675	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the thumb	Absence of the epiphysis located at the proximal end of the distal phalanx of the thumb.	UMLS:C4024242	hp.json	Absent end part of thumb outermost long bone	http://purl.obolibrary.org/obo/HP_0009675		
PR:P06744	biolink:Protein	glucose-6-phosphate isomerase (human)	A glucose-6-phosphate isomerase that is encoded in the genome of human.	UniProtKB:P06744	hp.json	GPI|sperm antigen 36 (human)|PGI (human)|SA-36 (human)|PHI (human)|phosphoglucose isomerase (human)|hGPI|phosphohexose isomerase (human)|neuroleukin (human)|NLK (human)|AMF (human)|autocrine motility factor (human)	http://purl.obolibrary.org/obo/PR_P06744		
HP:0007015	biolink:PhenotypicFeature	Poor gross motor coordination	An abnormality of the ability (skills) to perform a precise movement of large muscles with the intent to perform a specific act. Gross motor skills are required to mediate movements of the arms, legs, and other large body parts.	UMLS:C1867863	hp.json	Gross motor impairment	http://purl.obolibrary.org/obo/HP_0007015		
HP:0009678	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the thumb	Abnormally large size of the epiphysis located at the proximal end of the distal phalanx of the thumb with respect to age-dependent norms.	UMLS:C4021408	hp.json	Large terminal thumb phalanx epiphysis|Enlarged end part of thumb outermost long bone	http://purl.obolibrary.org/obo/HP_0009678		
HP:0009677	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the thumb	A cone-shaped appearance of the epiphysis of the distal phalanx of the thumb of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4021409	hp.json	Cone-shaped end part of thumb outermost long bone|Cone-shaped terminal thumb phalanx epiphysis	http://purl.obolibrary.org/obo/HP_0009677		
HP:0007016	biolink:PhenotypicFeature	Corticospinal tract hypoplasia		UMLS:C1844007	hp.json		http://purl.obolibrary.org/obo/HP_0007016		
HP:0009672	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the thumb	Abnormally small size of the epiphysis located at the proximal end of the proximal phalanx of the thumb with respect to age-dependent norms.	UMLS:C4024245	hp.json	Small end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009672		
HP:0009671	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the thumb	A pseudoepiphysis (which is a secondary ossification center distinct from the normal epiphysis) of the proximal phalanx of the thumb.	UMLS:C4024246	hp.json		http://purl.obolibrary.org/obo/HP_0009671		
HP:0007010	biolink:PhenotypicFeature	Poor fine motor coordination	An abnormality of the ability (skills) to perform a precise movement of small muscles with the intent to perform a specific act. Fine motor skills are required to mediate movements of the wrists, hands, fingers, feet, and toes.	UMLS:C1867864	hp.json	Impaired fine motor skills|Fine motor disability|Fine motor impairment|Fine motor skill dysfunction	http://purl.obolibrary.org/obo/HP_0007010		
HP:0007011	biolink:PhenotypicFeature	Fourth cranial nerve palsy	Paralysis of the fourth cranial (trochlear) nerve manifested as weakness of the superior oblique muscle which causes vertical diplopia that is maximal when the affected eye is adducted and directed inferiorly.	SNOMEDCT_US:20610004|MSH:D020432|UMLS:C0271375	hp.json	Trochlear nerve palsy	http://purl.obolibrary.org/obo/HP_0007011		
HP:0009674	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the thumb	A triangular appearance of the epiphysis of the proximal phalanx of the thumb of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024243	hp.json	Triangular end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009674		
HP:0009673	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the thumb	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024244	hp.json	Speckled calcifications in end part of thumb innermost long bone	http://purl.obolibrary.org/obo/HP_0009673		
HP:0007074	biolink:PhenotypicFeature	Thick corpus callosum	Increased vertical dimension of the corpus callosum. This feature can be visualized by sagittal sections on magnetic resonance tomography imaging of the brain.	UMLS:C1835194	hp.json	Abnormal size of corpus callosum|Large corpus callosum	http://purl.obolibrary.org/obo/HP_0007074		
UBERON:0012240	biolink:AnatomicalEntity	urethral meatus	External opening or orifice of the urethra through which urine and seminal fluid (in males only) leave the body; in males the meatus presents as a vertical slit normally positioned at the tip of glans penis; in females the meatus is located between the clitoris and the vagina in the vulvular vestibule of the female genitalia[MP].	FMA:19650|EMAPA:37977	hp.json	external urethral orifice|orificium urethrae externum|orificium urethræ externum|external urethral ostium|meatus urinarius|external urinary meatus|urethral meatus|urinary meatus|external meatus of urethra	http://purl.obolibrary.org/obo/UBERON_0012240		pheno_slim
GO:0050900	biolink:BiologicalProcess	leukocyte migration	The movement of a leukocyte within or between different tissues and organs of the body.		hp.json	leucocyte trafficking|immune cell trafficking|leucocyte migration|immune cell migration|leukocyte trafficking	http://purl.obolibrary.org/obo/GO_0050900		
HP:0020049	biolink:PhenotypicFeature	Exodeviation	A manifest or latent ocular deviation in which one or both eyes tends to deviate temporally.		hp.json	Divergent strabismus	http://purl.obolibrary.org/obo/HP_0020049		
CHEBI:25414	biolink:ChemicalSubstance	monoatomic monocation			hp.json	monovalent inorganic cations|monoatomic monocations	http://purl.obolibrary.org/obo/CHEBI_25414		3_STAR
UBERON:0012242	biolink:AnatomicalEntity	internal urethral orifice	The usually crescent-shaped opening of the urinary bladder into the urethra, placed at the anteroinferior angle (apex) of the urinary bladder trigone.	FMA:85263	hp.json	vesicourethral orifice|internal urethral ostium|internal urinary meatus|ostium orificium internum|internal meatus of urethra|internal urethral orifice of urinary bladder|ostium urethrae internum|internal urethral ostium|orificium urethrae internum	http://purl.obolibrary.org/obo/UBERON_0012242		pheno_slim
UBERON:0012241	biolink:AnatomicalEntity	male urethral meatus	A urethral meatus that is part of a male urethra[Automatically generated definition].	FMA:85265|EMAPA:36434|MA:0002642	hp.json	distal urethral opening of male|external orifice of male urethra|urethral meatus of penile urethra|urethral opening of penile urethra|external urethral orifice (male)|ostium urethrae externum (urethra masculina)|male urethra ostium	http://purl.obolibrary.org/obo/UBERON_0012241		
UBERON:0012248	biolink:AnatomicalEntity	cervical mucosa	Lining of the head of the uterus (cervix); contains large branched glands; does not undergo sloughing.	BTO:0000411	hp.json		http://purl.obolibrary.org/obo/UBERON_0012248		
GO:0050907	biolink:BiologicalProcess	detection of chemical stimulus involved in sensory perception	The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception.		hp.json	sensory perception, sensory transduction of chemical stimulus|sensory transduction of chemical stimulus during sensory perception|sensory perception, sensory detection of chemical stimulus|sensory transduction of chemical stimulus|sensory detection of chemical stimulus during sensory perception|sensory detection of chemical stimulus	http://purl.obolibrary.org/obo/GO_0050907		
GO:0050908	biolink:BiologicalProcess	detection of light stimulus involved in visual perception	The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.		hp.json	sensory transduction of light stimulus during visual perception|visual perception, detection of light stimulus|sensory transduction of light during visual perception|visual perception, sensory transduction of light stimulus|sensory detection of light stimulus during visual perception|visual perception, sensory transduction during perception of light|sensory detection of light during visual perception	http://purl.obolibrary.org/obo/GO_0050908		
UBERON:0012247	biolink:AnatomicalEntity	cervical gland	Mucus-secreting glands in the mucosa of the uterine cervix.	UMLS:C2724437|NCIT:C32296	hp.json	glandulae cervicales	http://purl.obolibrary.org/obo/UBERON_0012247		human_reference_atlas
GO:0050905	biolink:BiologicalProcess	neuromuscular process	Any process pertaining to the functions of the nervous and muscular systems of an organism.		hp.json	neuromotor process|neuromuscular physiological process	http://purl.obolibrary.org/obo/GO_0050905		
GO:0050906	biolink:BiologicalProcess	detection of stimulus involved in sensory perception	The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal.	Wikipedia:Transduction_(physiology)	hp.json	sensory perception, stimulus detection|sensory detection of stimulus|sensory transduction|sensory perception, sensory transduction of stimulus	http://purl.obolibrary.org/obo/GO_0050906		
GO:2001198	biolink:BiologicalProcess	regulation of dendritic cell differentiation	Any process that modulates the frequency, rate or extent of dendritic cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2001198		
UBERON:0012239	biolink:AnatomicalEntity	urinary bladder vasculature	Network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys[MP].	EMAPA:28679	hp.json	blood vessel of bladder|bladder vasculature|set of urinary bladder blood vessels|blood vessels of bladder	http://purl.obolibrary.org/obo/UBERON_0012239		pheno_slim|human_reference_atlas
GO:2001199	biolink:BiologicalProcess	negative regulation of dendritic cell differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2001199		
HP:0020046	biolink:PhenotypicFeature	Accommodative esotropia	A form of esotropia (convergent deviation of the eyes) associated with activation of the accommodative reflex.		hp.json		http://purl.obolibrary.org/obo/HP_0020046		
HP:0007068	biolink:PhenotypicFeature	Inferior cerebellar vermis hypoplasia	Underdevelopment of the inferior portion of the vermis of cerebellum.	UMLS:C1855350	hp.json	Hypoplasia of inferior vermis|Inferior vermis hypoplasia	http://purl.obolibrary.org/obo/HP_0007068		
HP:0020045	biolink:PhenotypicFeature	Esodeviation	A manifest or latent ocular deviation in which one or both eyes tends to deviate nasally.		hp.json	Convergent squint|Convergent strabismus	http://purl.obolibrary.org/obo/HP_0020045		
HP:0007069	biolink:PhenotypicFeature	Profound static encephalopathy		UMLS:C4024944	hp.json		http://purl.obolibrary.org/obo/HP_0007069		
HP:0020048	biolink:PhenotypicFeature	Reduced bone-marrow pro-B cell count	A reduction in the numbers of pro-B cells (defined by coexpression of CD34 and CD19). Earlier B-cell precursors are defined by expressing surface CD34 and cytoplasmic TdT in the absence of CD19.		hp.json		http://purl.obolibrary.org/obo/HP_0020048		
HP:0020047	biolink:PhenotypicFeature	Abnormal myeloid cell morphology	Any structural anomaly of a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.		hp.json		http://purl.obolibrary.org/obo/HP_0020047		
HP:0020042	biolink:PhenotypicFeature	Double depressor palsy	An ocular movement abnormality characterised by simultaneous weakness of the inferior rectus muscle and superior oblique muscle of the same eye.		hp.json		http://purl.obolibrary.org/obo/HP_0020042		
HP:0007064	biolink:PhenotypicFeature	Progressive language deterioration	Progressive loss of previously present language abilities.	UMLS:C1843793	hp.json		http://purl.obolibrary.org/obo/HP_0007064		
HP:0020041	biolink:PhenotypicFeature	Double elevator palsy	A type of incomitant strabismus in which both elevator muscles (i.e., the inferior oblique and superior rectus muscles) of the same eye are weak leading to restricted elevation and hypotropia.		hp.json		http://purl.obolibrary.org/obo/HP_0020041		
HP:0007065	biolink:PhenotypicFeature	Disorganization of the anterior cerebellar vermis		UMLS:C1845369	hp.json	Disorganisation of the anterior cerebellar vermis	http://purl.obolibrary.org/obo/HP_0007065		
HP:0020044	biolink:PhenotypicFeature	Horizontal incomitant strabismus			hp.json		http://purl.obolibrary.org/obo/HP_0020044		
HP:0007066	biolink:PhenotypicFeature	Proximal limb muscle stiffness	Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in the proximal limb muscle.	UMLS:C1861460	hp.json		http://purl.obolibrary.org/obo/HP_0007066		
HP:0007067	biolink:PhenotypicFeature	Distal peripheral sensory neuropathy	Peripheral sensory neuropathy affecting primarily distal sensation.	UMLS:C4021582	hp.json	Peripheral sensory neuropathy, distal	http://purl.obolibrary.org/obo/HP_0007067		
HP:0020043	biolink:PhenotypicFeature	Vertical incomitant strabismus	A type of incomitant strabismus in which the angle of deviation varies as the patient's gaze shifts upwards and/or downwards.		hp.json		http://purl.obolibrary.org/obo/HP_0020043		
HP:0007082	biolink:PhenotypicFeature	Dilated third ventricle	An increase in size of the third ventricle.	UMLS:C4024941	hp.json		http://purl.obolibrary.org/obo/HP_0007082		
HP:0007083	biolink:PhenotypicFeature	Hyperactive patellar reflex		UMLS:C0240116	hp.json	Hyperreflexia in knees|Brisk knee jerk|Overactive knee reflex	http://purl.obolibrary.org/obo/HP_0007083		
UBERON:0014890	biolink:AnatomicalEntity	right hemisphere of cerebellum	A cerebellar hemisphere that is in_the_right_side_of a cerebellum.	FMA:83876	hp.json		http://purl.obolibrary.org/obo/UBERON_0014890		pheno_slim
UBERON:0014891	biolink:AnatomicalEntity	brainstem white matter	White matter that is part of a brainstem [Automatically generated definition].	FMA:282112|SCTID:360442003|EMAPA:35189|MA:0002741	hp.json	brainstem tracts|brainstem tracts and commissures|brainstem tract/commissure|brain stem white matter	http://purl.obolibrary.org/obo/UBERON_0014891		pheno_slim
GO:0050910	biolink:BiologicalProcess	detection of mechanical stimulus involved in sensory perception of sound	The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.		hp.json	sensory detection of mechanical stimulus during perception of sound|perception of sound, sensory detection of mechanical stimulus|perception of sound, detection of mechanical stimulus|detection of sound|hearing, sensory transduction of sound|sensory transduction of mechanical stimulus during perception of sound|perception of sound, sensory transduction of mechanical stimulus|sensory transduction of sound	http://purl.obolibrary.org/obo/GO_0050910		
GO:0050911	biolink:BiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal.		hp.json	sensory transduction of scent|sensory detection of chemical stimulus during perception of smell|sensory transduction of smell|perception of smell, sensory transduction of chemical stimulus|sensory detection of scent|sensory transduction of chemical stimulus during perception of smell|sensory detection of smell|perception of smell, sensory detection of chemical stimulus|perception of smell, detection of chemical stimulus	http://purl.obolibrary.org/obo/GO_0050911		
HP:0020038	biolink:PhenotypicFeature	Vertebrobasilar dolichoectasia	Elongation, dilatation, and/or tortuosity of the vertebrobasilar segment. The definition of VBD includes: (i) diameter of basilar or vertebral artery over 4.5 mm; or (ii) deviation of any portion more than 10 mm from the shortest expected course; and (iii) length of basilar artery over 29.5 mm or length of intracranial vertebral artery over 23.5 mm.		hp.json		http://purl.obolibrary.org/obo/HP_0020038		
HP:0007081	biolink:PhenotypicFeature	Late-onset muscular dystrophy		UMLS:C4024942	hp.json		http://purl.obolibrary.org/obo/HP_0007081		
GO:0050912	biolink:BiologicalProcess	detection of chemical stimulus involved in sensory perception of taste	The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal.		hp.json	taste perception|perception of taste, sensory transduction of chemical stimulus|sensory transduction of taste|sensory detection of chemical stimulus during perception of taste|sensory detection of taste|sensory transduction of chemical stimulus during perception of taste|perception of taste, sensory detection of chemical stimulus|perception of taste, detection of chemical stimulus	http://purl.obolibrary.org/obo/GO_0050912		
UBERON:0014892	biolink:AnatomicalEntity	skeletal muscle organ	A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles).	EFO:0000888|MA:0003148|VHOG:0000319|MAT:0000302|XAO:0000174|GAID:141|EV:0100377|EHDAA:5984|ZFA:0005277|MIAA:0000302|CALOHA:TS-0933|EMAPA:35988|BTO:0001103|EHDAA:5035|TAO:0005277|AAO:0011099|EHDAA:5043|OpenCyc:Mx4rv2kf-5wpEbGdrcN5Y29ycA|EHDAA:5978|MESH:D018482	hp.json	skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0014892		
UBERON:0012236	biolink:AnatomicalEntity	intercostal lymph node	The intercostal lymph nodes (intercostal glands ) occupy the posterior parts of the intercostal spaces, in relation to the intercostal vessels. They receive the deep lymphatics from the postero-lateral aspect of the chest; some of these vessels are interrupted by small lateral intercostal glands.	NCIT:C77652|UMLS:C0229761|FMA:5932	hp.json	nodus intercostale|intercostal node|nodi lymphoidei intercostales	http://purl.obolibrary.org/obo/UBERON_0012236		
GO:0050909	biolink:BiologicalProcess	sensory perception of taste	The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process.	Wikipedia:Taste	hp.json	taste|gustation|sense of taste|taste perception	http://purl.obolibrary.org/obo/GO_0050909		
UBERON:0014889	biolink:AnatomicalEntity	left hemisphere of cerebellum	A cerebellar hemisphere that is in_the_left_side_of a cerebellum.	FMA:83877	hp.json		http://purl.obolibrary.org/obo/UBERON_0014889		pheno_slim
GO:0001909	biolink:BiologicalProcess	leukocyte mediated cytotoxicity	The directed killing of a target cell by a leukocyte.		hp.json	leucocyte mediated cytotoxicity|immune cell mediated cytotoxicity|immune cell mediated cell death|immune cell mediated cell killing	http://purl.obolibrary.org/obo/GO_0001909		
HP:0020035	biolink:PhenotypicFeature	Lower limb dysmetria	A lack of coordination of leg movement manifested by undershoot or overshoot of the intended position of the leg.		hp.json		http://purl.obolibrary.org/obo/HP_0020035		
HP:0020034	biolink:PhenotypicFeature	Diffuse	A spatial pattern that is spread out, i.e., not localized.	SNOMEDCT_US:19648000|UMLS:C0205219	hp.json		http://purl.obolibrary.org/obo/HP_0020034		
HP:0020037	biolink:PhenotypicFeature	Astasia	A postural abnormality characterized by the inability to stand without external support despite having sufficient muscle strength.		hp.json		http://purl.obolibrary.org/obo/HP_0020037		
HP:0020036	biolink:PhenotypicFeature	Upper limb dysmetria	A lack of coordination of arm movement manifested by undershoot or overshoot of the intended position of the arm.		hp.json		http://purl.obolibrary.org/obo/HP_0020036		
GO:0001906	biolink:BiologicalProcess	cell killing	Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.		hp.json	necrosis	http://purl.obolibrary.org/obo/GO_0001906		goslim_pir
HP:0007076	biolink:PhenotypicFeature	Extrapyramidal muscular rigidity	Muscular rigidity (continuous contraction of muscles with constant resistance to passive movement).	UMLS:C1852470	hp.json		http://purl.obolibrary.org/obo/HP_0007076		
HP:0007078	biolink:PhenotypicFeature	Decreased amplitude of sensory action potentials	A reduction in the amplitude of sensory nerve action potential. This feature is measured by nerve conduction studies.	UMLS:C4024943	hp.json		http://purl.obolibrary.org/obo/HP_0007078		
HP:0007052	biolink:PhenotypicFeature	Multifocal cerebral white matter abnormalities		UMLS:C1833434	hp.json		http://purl.obolibrary.org/obo/HP_0007052		
GO:0050921	biolink:BiologicalProcess	positive regulation of chemotaxis	Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.		hp.json	upregulation of chemotaxis|stimulation of chemotaxis|up regulation of chemotaxis|up-regulation of chemotaxis|activation of chemotaxis	http://purl.obolibrary.org/obo/GO_0050921		
GO:0050922	biolink:BiologicalProcess	negative regulation of chemotaxis	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.		hp.json	down regulation of chemotaxis|inhibition of chemotaxis|down-regulation of chemotaxis|downregulation of chemotaxis	http://purl.obolibrary.org/obo/GO_0050922		
GO:0050920	biolink:BiologicalProcess	regulation of chemotaxis	Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.		hp.json		http://purl.obolibrary.org/obo/GO_0050920		
UBERON:0014885	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of manual digit 5	A distal epiphysis that is part of a distal phalanx of manual digit 5.	FMA:37657	hp.json	head of distal phalanx of fifth digit of hand|distal epiphysis of distal phalanx of manual digit V|distal epiphysis of distal phalanx of little finger|head of distal phalanx of fifth finger|distal end of distal phalanx of little finger|ungual tuberosity of distal phalanx of little finger|distal end of distal phalanx of fifth finger|head of distal phalanx of little finger	http://purl.obolibrary.org/obo/UBERON_0014885		
UBERON:0014886	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of manual digit			hp.json	distal end of distal phalanx of finger|head of distal phalanx of digit of manus|head of distal phalanx of digit of hand|head of distal phalanx of finger	http://purl.obolibrary.org/obo/UBERON_0014886		
UBERON:0014887	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of digit	A distal epiphysis that is part of a distal phalanx.		hp.json	head of distal phalanx of digit of autopod|distal end of distal phalanx of digit|head of distal phalanx|head of distal phalanx of digit	http://purl.obolibrary.org/obo/UBERON_0014887		
UBERON:0014881	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of manual digit 1	A distal epiphysis that is part of a distal phalanx of manual digit 1.	FMA:37609	hp.json	distal end of phalanx of right thumb|distal epiphysis of distal phalanx of thumb|ungual tuberosity of distal phalanx of thumb|head of distal phalanx of thumb|head of distal phalanx of first digit of hand|distal epiphysis of distal phalanx of manual digit I	http://purl.obolibrary.org/obo/UBERON_0014881		
UBERON:0014882	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of manual digit 2	A distal epiphysis that is part of a distal phalanx of manual digit 2.	FMA:37621	hp.json	distal end of distal phalanx of second finger|distal end of distal phalanx of index finger|distal epiphysis of distal phalanx of index finger|head of distal phalanx of second finger|ungual tuberosity of distal phalanx of index finger|distal epiphysis of distal phalanx of manual digit II|head of distal phalanx of index finger	http://purl.obolibrary.org/obo/UBERON_0014882		
UBERON:0014883	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of manual digit 3	A distal epiphysis that is part of a distal phalanx of manual digit 3.	FMA:37633	hp.json	distal epiphysis of distal phalanx of manual digit III|distal epiphysis of distal phalanx of middle finger|head of distal phalanx of third finger|distal end of distal phalanx of middle finger|ungual tuberosity of distal phalanx of middle finger|distal end of distal phalanx of third finger|head of distal phalanx of middle finger|head of distal phalanx of third digit of hand	http://purl.obolibrary.org/obo/UBERON_0014883		
UBERON:0014884	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of manual digit 4	A distal epiphysis that is part of a distal phalanx of manual digit 4.	FMA:37645	hp.json	ungual tuberosity of distal phalanx of ring finger|head of distal phalanx of ring finger|head of distal phalanx of fourth digit of hand|distal end of distal phalanx of fourth finger|head of distal phalanx of fourth finger|distal epiphysis of distal phalanx of ring finger|distal end of distal phalanx of ring finger|distal epiphysis of distal phalanx of manual digit IV	http://purl.obolibrary.org/obo/UBERON_0014884		
HP:0007047	biolink:PhenotypicFeature	Atrophy of the dentate nucleus	Partial or complete wasting (loss) of dentate nucleus.	UMLS:C1857788	hp.json		http://purl.obolibrary.org/obo/HP_0007047		
HP:0007048	biolink:PhenotypicFeature	Large basal ganglia	Increased size of the basal ganglia.	UMLS:C1859470	hp.json		http://purl.obolibrary.org/obo/HP_0007048		
HP:0007042	biolink:PhenotypicFeature	Focal white matter lesions		UMLS:C4024946	hp.json		http://purl.obolibrary.org/obo/HP_0007042		
HP:0007045	biolink:PhenotypicFeature	Midline brain calcifications		UMLS:C1855487	hp.json		http://purl.obolibrary.org/obo/HP_0007045		
HP:0010690	biolink:PhenotypicFeature	Mirror image hand polydactyly	Mirror image duplication of digits affecting the hands only.	UMLS:C4021239	hp.json	Mirror image dupliction of fingers	http://purl.obolibrary.org/obo/HP_0010690		hposlim_core
HP:0007063	biolink:PhenotypicFeature	Aplasia of the inferior half of the cerebellar vermis		UMLS:C1857787	hp.json	Absent inferior half of the cerebellar vermis	http://purl.obolibrary.org/obo/HP_0007063		
GO:0050932	biolink:BiologicalProcess	regulation of pigment cell differentiation	Any process that modulates the frequency, rate or extent of pigmented cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0050932		
GO:0050931	biolink:BiologicalProcess	pigment cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte.		hp.json	chromatophore differentiation|pigmented cell differentiation	http://purl.obolibrary.org/obo/GO_0050931		
HP:0010698	biolink:PhenotypicFeature	Nuclear pulverulent cataract	A type of nuclear cataract involving congenital dust-like (pulverulent) opacity of the embryonal and fetal nucleus.	UMLS:C4021237	hp.json	cataracta pulverulenta centralis|Coppock-like cataract|Central pulverulent cataract|Pulverulent nuclear cataract	http://purl.obolibrary.org/obo/HP_0010698		
UBERON:0014874	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of pedal digit 4	A distal epiphysis that is part of a distal phalanx of pedal digit 4.	FMA:33091	hp.json	head of distal phalanx of fourth toe|distal epiphysis of distal phalanx of pedal digit IV|ungal tuberosity of distal phalanx of fourth toe|distal end of distal phalanx of fourth toe|distal epiphysis of distal phalanx of fourth toe|head of distal phalanx of fourth digit of foot	http://purl.obolibrary.org/obo/UBERON_0014874		
HP:0010697	biolink:PhenotypicFeature	Anterior pyramidal cataract	A type of anterior polar cataract which projects as a conical opacity into the anterior chamber.	UMLS:C1392099	hp.json	Pyramidal cataract	http://purl.obolibrary.org/obo/HP_0010697		
UBERON:0014875	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of pedal digit 5	A distal epiphysis that is part of a distal phalanx of pedal digit 5.	FMA:33106	hp.json	distal end of distal phalanx of little toe|ungual tuberosity of distal phalanx of fifth toe|distal epiphysis of distal phalanx of little toe|head of distal phalanx of fifth toe|head of distal phalanx of fifth digit of foot|head of distal phalanx of little toe|distal epiphysis of distal phalanx of pedal digit V	http://purl.obolibrary.org/obo/UBERON_0014875		
UBERON:0014876	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of pedal digit			hp.json	distal end of distal phalanx of toe|head of distal phalanx of digit of pes|head of distal phalanx of toe|head of distal phalanx of digit of foot	http://purl.obolibrary.org/obo/UBERON_0014876		
HP:0010696	biolink:PhenotypicFeature	Polar cataract	A type of Congenital cataract in which the opacities occupy the subcapsular cortex at the anterior or posterior pole of the lens.	UMLS:C2025392	hp.json		http://purl.obolibrary.org/obo/HP_0010696		
HP:0010695	biolink:PhenotypicFeature	Sutural cataract	A type of congenital cataract in which the opacity follows the anterior or posterior Y suture.	UMLS:C4023734	hp.json		http://purl.obolibrary.org/obo/HP_0010695		
HP:0010694	biolink:PhenotypicFeature	Lamellar pulverulent cataract	A Lamellar cataract with a pulverulent (punctate, "dust-like" opacities) appearance.	UMLS:C4023735	hp.json		http://purl.obolibrary.org/obo/HP_0010694		
HP:0010693	biolink:PhenotypicFeature	Pulverulent cataract	A kind of congenital cataract that is characterized by a hollow sphere of punctate opacities involving the fetal nucleus and that usually occurs bilaterally.	MSH:C563426|UMLS:C1833118	hp.json	Pulverulent cataract	http://purl.obolibrary.org/obo/HP_0010693		
UBERON:0014871	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of pedal digit 1	A distal epiphysis that is part of a distal phalanx of pedal digit 1.	FMA:33036	hp.json	ungual tuberosity of distal phalanx of big toe|head of distal phalanx of big toe|head of distal phalanx of great toe|distal epiphysis of distal phalanx of pedal digit I|head of distal phalanx of first digit of foot|distal epiphysis of distal phalanx of big toe|distal end of distal phalanx of big toe	http://purl.obolibrary.org/obo/UBERON_0014871		
UBERON:0014872	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of pedal digit 2	A distal epiphysis that is part of a distal phalanx of pedal digit 2.	FMA:33045	hp.json	ungual tuberosity of distal phalanx of second toe|distal epiphysis of distal phalanx of pedal digit II|head of distal phalanx of second toe|distal end of distal phalanx of second toe|distal epiphysis of distal phalanx of second toe	http://purl.obolibrary.org/obo/UBERON_0014872		
HP:0010692	biolink:PhenotypicFeature	2-5 finger syndactyly	Syndactyly with fusion of fingers two to five.	UMLS:C4023736	hp.json	Webbed 2nd-5th fingers|Webbed index, middle and pinky finger|Webbed index, middle and pinkie finger|Webbed index, middle and little finger	http://purl.obolibrary.org/obo/HP_0010692		
UBERON:0014873	biolink:AnatomicalEntity	distal epiphysis of distal phalanx of pedal digit 3	A distal epiphysis that is part of a distal phalanx of pedal digit 3.	FMA:33054	hp.json	distal epiphysis of distal phalanx of third toe|distal end of distal phalanx of third toe|ungual tuberosity of distal phalanx of third toe|head of distal phalanx of third toe|distal epiphysis of distal phalanx of pedal digit III|head of distal phalanx of third digit of foot	http://purl.obolibrary.org/obo/UBERON_0014873		
HP:0010691	biolink:PhenotypicFeature	Mirror image foot polydactyly	Mirror image duplication of digits affecting the feet.	UMLS:C4021238	hp.json	Mirror image dupliction of toes	http://purl.obolibrary.org/obo/HP_0010691		
HP:0010699	biolink:PhenotypicFeature	Triangular nuclear cataract	A nuclear cataract with a triangular form.	UMLS:C4023733	hp.json		http://purl.obolibrary.org/obo/HP_0010699		
HP:0007057	biolink:PhenotypicFeature	Poor hand-eye coordination		UMLS:C1845864	hp.json		http://purl.obolibrary.org/obo/HP_0007057		
HP:0007058	biolink:PhenotypicFeature	Generalized cerebral atrophy/hypoplasia	Generalized atrophy or hypoplasia of the cerebrum.	UMLS:C4024945	hp.json	Generalized cerebral degeneration/underdevelopment|Generalised cerebral degeneration/underdevelopment|Generalised cerebral atrophy/hypoplasia	http://purl.obolibrary.org/obo/HP_0007058		
HP:0007054	biolink:PhenotypicFeature	Proximal hyperreflexia	Hyperactive stretch reflexes of muscles that move proximal joints (elbow, knee).	UMLS:C1836012	hp.json	Hyperreflexia proximally	http://purl.obolibrary.org/obo/HP_0007054		
GO:0035306	biolink:BiologicalProcess	positive regulation of dephosphorylation	Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule.		hp.json	up-regulation of dephosphorylation|up regulation of dephosphorylation|activation of dephosphorylation|stimulation of dephosphorylation|upregulation of dephosphorylation	http://purl.obolibrary.org/obo/GO_0035306		
HP:0010607	biolink:PhenotypicFeature	Hordeolum externum	Hordeola externa are acute purulent infections affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll, often caused by staphylococcus infections. In contrast to chalazia, hordeola are extremely painfull and can cause extreme local swelling.	UMLS:C0019919|SNOMEDCT_US:1489008	hp.json		http://purl.obolibrary.org/obo/HP_0010607		
HP:0009606	biolink:PhenotypicFeature	Complete duplication of distal phalanx of the thumb	Complete duplication of the distal phalanx of the thumb. On x-ray two separate bones appear side to side.	UMLS:C4021427	hp.json	Complete duplication of outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009606		
HP:0010606	biolink:PhenotypicFeature	Hordeolum	An acute purulent infection of the sebaceous glands of Zeis at the base of the eyelashes, of the apocrine sweat glands of Moll or the meibomian sebacious glands often caused by staphylococcus infections. Hordeola can either occur as Hordeola externa affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll or as Hordeola interna affecting the meibomian sebacious glands. In contrast to chalazia, hordeola are extremely painful and can cause extreme local swelling.	SNOMEDCT_US:397513003|UMLS:C4280376|MSH:D006726|UMLS:C0019917|SNOMEDCT_US:1489008	hp.json	Stye of eyelid|Red bump on eyelid	http://purl.obolibrary.org/obo/HP_0010606		
HP:0009609	biolink:PhenotypicFeature	Duplication of the 1st metacarpal	Partail or complete duplication of the first metacarpal bone.	UMLS:C4021426	hp.json	Partial/complete duplication of the 1st long bone of hand|Partial/complete duplication of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0009609		
HP:0010605	biolink:PhenotypicFeature	Chalazion	A chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland. A chalazion or meibomian cyst appears as a painless tuberous swelling in the upper lid without loss of eyelashes.	MSH:D017043|SNOMEDCT_US:1482004|UMLS:C0007933	hp.json	Meibomian gland lipogranuloma	http://purl.obolibrary.org/obo/HP_0010605		
HP:0009608	biolink:PhenotypicFeature	Complete duplication of proximal phalanx of the thumb	Complete duplication of the proximal phalanx of the thumb. On x-ray two separate bones appear side to side. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024273	hp.json	Complete duplication of the innermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009608		
HP:0010604	biolink:PhenotypicFeature	Cyst of the eyelid		SNOMEDCT_US:301913002|SNOMEDCT_US:248514008|UMLS:C0155218|SNOMEDCT_US:46210008|UMLS:C0578590|UMLS:C0424844	hp.json	Lesion of the eyelid|Eyelid bump|Eyelid mass|Cyst of the eyelid	http://purl.obolibrary.org/obo/HP_0010604		
HP:0010603	biolink:PhenotypicFeature	Odontogenic keratocysts of the jaw	A benign uni- or multicystic, intraosseous tumor of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour.	UMLS:C1708604	hp.json	Keratocystic odontogenic tumour|Keratocysts of the jaw|Keratocystic odontogenic tumor	http://purl.obolibrary.org/obo/HP_0010603		
HP:0009603	biolink:PhenotypicFeature	Deviation of the thumb	Displacement of the thumb from its normal position.	UMLS:C3552414	hp.json	Abnormal thumb placement|Deviated thumb|Displacement of the thumb	http://purl.obolibrary.org/obo/HP_0009603		
HP:0009602	biolink:PhenotypicFeature	Abnormality of thumb phalanx	A structural anomaly of one or more phalanges of the thumb.	UMLS:C4021428	hp.json	Abnormality of the thumb bones|Abnormality of thumb phalanges	http://purl.obolibrary.org/obo/HP_0009602		
GO:0035303	biolink:BiologicalProcess	regulation of dephosphorylation	Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule.		hp.json		http://purl.obolibrary.org/obo/GO_0035303		
HP:0010602	biolink:PhenotypicFeature	Type 2 muscle fiber predominance	An abnormal predominance of type II muscle fibers (in general, this feature can only be observed on muscle biopsy).	UMLS:C3277187	hp.json	Type II muscle fibre predominance|Type 2 muscle fibre predominance|Type II muscle fiber predominance	http://purl.obolibrary.org/obo/HP_0010602		
HP:0010601	biolink:PhenotypicFeature	Abnormal proximal ulnar epiphysis morphology	Any abnormality of the proximal epiphysis of the ulna.	UMLS:C4023772	hp.json	Abnormality of the proximal ulnar epiphysis	http://purl.obolibrary.org/obo/HP_0010601		
GO:0035305	biolink:BiologicalProcess	negative regulation of dephosphorylation	Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule.		hp.json	down regulation of dephosphorylation|downregulation of dephosphorylation|inhibition of dephosphorylation|down-regulation of dephosphorylation	http://purl.obolibrary.org/obo/GO_0035305		
HP:0010600	biolink:PhenotypicFeature	Abnormal distal ulnar epiphysis morphology	Any abnormality of the distal epiphysis of the ulna.	UMLS:C4023773	hp.json	Abnormality of the distal ulnar epiphysis	http://purl.obolibrary.org/obo/HP_0010600		
HP:0009601	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the thumb	Hypoplastic/small or absent thumb.	MSH:C536903|UMLS:C3179508	hp.json	Absent/hypoplastic thumb|Hypoplastic/absent thumb|Aplastic/hypoplastic thumbs|Absent/underdeveloped thumb|Hypoplastic to aplastic thumbs|Thumb aplasia/hypoplasia|Aplasia/hypoplasia of thumbs|Absent/hypoplastic thumbs|Absent or hypoplastic thumbs|Absent/small thumb	http://purl.obolibrary.org/obo/HP_0009601		
HP:0009600	biolink:PhenotypicFeature	Flexion contracture of thumb	Chronic loss of joint motion in the thumb due to structural changes in non-bony tissue. The term camptodactyly is used if the distal and/or proximal interphalangeal joints are affected.	SNOMEDCT_US:239736003|UMLS:C0409346	hp.json	Flexion deformities of thumbs|Joint contractures of the thumb|Contracture of thumb	http://purl.obolibrary.org/obo/HP_0009600		
HP:0010609	biolink:PhenotypicFeature	Skin tags	Cutaneous skin tags also known as acrochorda or fibroepithelial polyps are small benign tumours that may either form secondarily over time primarily in areas where the skin forms creases, such as the neck, armpit or groin or may also be present at birth, in which case they usually occur in the periauricular region.	SNOMEDCT_US:201091002|SNOMEDCT_US:80801001|SNOMEDCT_US:31069005|UMLS:C0037293	hp.json	Acrochorda	http://purl.obolibrary.org/obo/HP_0010609		
HP:0010608	biolink:PhenotypicFeature	Hordeolum internum	Hordeola interna are acute purulent infections affecting the meibomian sebacious glands, often caused by staphylococcus infections. In contrast to chalazia (chronic epithelioid cell granulomatous inflammation of the meibomian gland caused by inflammation of a blocked meibomian gland), hordeola are extremely painfull and can cause extreme local swelling.	UMLS:C0085690|SNOMEDCT_US:414521009|UMLS:C4280375	hp.json	Red bump on inner eyelid|Stye of inner eyelid	http://purl.obolibrary.org/obo/HP_0010608		
HP:0009618	biolink:PhenotypicFeature	Abnormality of the proximal phalanx of the thumb	An anomaly of the shape or form of the proximal phalanx of the thumb.	UMLS:C4021421	hp.json	Abnormality of proximal thumb phalanx|Abnormal innermost thumb bone	http://purl.obolibrary.org/obo/HP_0009618		
HP:0009617	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the thumb	Any anomaly of the distal phalanx of thumb.	UMLS:C4021422	hp.json	Abnormality of terminal thumb phalanx|Abnormality of the outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009617		
HP:0009614	biolink:PhenotypicFeature	Bifid proximal phalanx of the thumb	This term applies if the proximal phalanx of the thumb is partially duplicated. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx) to a partially fused appearance of the two bones. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024272	hp.json	Notched thumb bone	http://purl.obolibrary.org/obo/HP_0009614		
HP:0009613	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the thumb	Complete or partial duplication of the proximal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones, or two separate bones appearing side to side. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4021424	hp.json	Partial/complete duplication of the proximal phalanx of the thumb|Notched innermost bone of thumb	http://purl.obolibrary.org/obo/HP_0009613		
HP:0009616	biolink:PhenotypicFeature	Bifid first metacarpal	Partial duplication of the first metacarpal bone.	UMLS:C4021423	hp.json	Notched first long bone of hand|partial duplication of the first metacarpal	http://purl.obolibrary.org/obo/HP_0009616		
HP:0009615	biolink:PhenotypicFeature	Complete duplication of the first metacarpal	Complete duplication of the first metacarpal bone.	UMLS:C4024271	hp.json	Complete duplication of the first long bone of hand	http://purl.obolibrary.org/obo/HP_0009615		
HP:0009612	biolink:PhenotypicFeature	Duplication of the distal phalanx of the thumb	Complete or partial duplication of the distal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx), a partially fused appearance of the two bones, or two separate bones appearing side to side.	UMLS:C4021425	hp.json	Double thumb distal phalanges|Duplication of the outermost bone of the thumb|Partial/complete duplication of the distal phalanx of the thumb|Duplication of distal thumb phalanx|Duplicated terminal phalanx of thumb|Duplication of terminal thumb phalanx	http://purl.obolibrary.org/obo/HP_0009612		
HP:0009611	biolink:PhenotypicFeature	Bifid distal phalanx of the thumb	Partial duplication of the distal phalanx of the thumb. Depending on the severity, the appearance on x-ray can vary from a notched phalanx (the duplicated bone is almost completely fused with the phalanx) to a partially fused appearance of the two bones.	UMLS:C1860162	hp.json	Notched outermost bone of thumb|Bifid distal phalanx of thumb|Bifid terminal phalanges of thumbs|Bifid thumb distal phalanx|Notched outermost bone of the thumb|Incipient distal thumb phalanx duplication|Notched terminal thumb phalanx	http://purl.obolibrary.org/obo/HP_0009611		
GO:0001990	biolink:NamedThing	regulation of systemic arterial blood pressure by hormone			hp.json		http://purl.obolibrary.org/obo/GO_0001990		
GO:0001992	biolink:NamedThing	regulation of systemic arterial blood pressure by vasopressin			hp.json		http://purl.obolibrary.org/obo/GO_0001992		
HP:0010643	biolink:PhenotypicFeature	Midnasal atresia	Absence or abnormal closure of the midnasal cavity.	UMLS:C4023762	hp.json		http://purl.obolibrary.org/obo/HP_0010643		
HP:0010641	biolink:PhenotypicFeature	Abnormality of the midnasal cavity	Abnormality of the midnasal cavity which includes the cavity between the nares and the choanae.	UMLS:C4021861	hp.json		http://purl.obolibrary.org/obo/HP_0010641		
HP:0010640	biolink:PhenotypicFeature	Abnormality of the nasal cavity	Abnormality of the nasal cavity (the cavity includes and starts at the nares and reaches all the way through to the and includes the choanae, the posterior nasal apertures).	UMLS:C4023763	hp.json		http://purl.obolibrary.org/obo/HP_0010640		
HP:0010649	biolink:PhenotypicFeature	Flat nasal alae	An abnormal degree of flatness of the Ala of nose, which can be defined as a reduced nasal elevation index (lateral depth of the nose from the tip of the nose to the insertion of the nasal ala in the cheek x 100 divided by the side-to-side breadth of the nasal alae).	UMLS:C4023759	hp.json	Flat nasal alar cartilage|Depressed nasal alae	http://purl.obolibrary.org/obo/HP_0010649		
HP:0010648	biolink:PhenotypicFeature	Dermal translucency	An abnormally increased ability of the skin to permit light to pass through (translucency) such that subcutaneous structures such as veins display an increased degree of visibility.	UMLS:C1836646	hp.json	Translucent skin	http://purl.obolibrary.org/obo/HP_0010648		hposlim_core
HP:0010647	biolink:PhenotypicFeature	Abnormal elasticity of skin	Any abnormal increase or reduction in skin elasticity.	UMLS:C4023760	hp.json		http://purl.obolibrary.org/obo/HP_0010647		
HP:0010646	biolink:PhenotypicFeature	Cervical spine instability	An abnormal lack of stability of the cervical spine.	SNOMEDCT_US:202821008|UMLS:C0410652	hp.json		http://purl.obolibrary.org/obo/HP_0010646		
HP:0009646	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the thumb	An uneven increase in bone density of the distal phalanx of the thumb.	UMLS:C4024258	hp.json	Uneven increase in bone density in the outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009646		
HP:0010645	biolink:PhenotypicFeature	Aplasia of the distal phalanges of the toes	Absence of the distal phalanges of the toes.	UMLS:C4023761	hp.json	Absent outermost bone of the toes	http://purl.obolibrary.org/obo/HP_0010645		
HP:0009649	biolink:PhenotypicFeature	Aplasia of the distal phalanx of the thumb	Absence of the distal/terminal phalanx of the thumb.	UMLS:C4021416	hp.json	Absent ossification/absent terminal thumb phalanx|Aplasia of the outermost bone of the thumb|Absence of the outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009649		
HP:0010644	biolink:PhenotypicFeature	Midnasal stenosis	Abnormal narrowing (stenosis) of the midnasal cavity, i.e., of the middle nasal meatus, which in neonates can cause respiratory distress.	UMLS:C1840238	hp.json	Midnasal atresia or stenosis	http://purl.obolibrary.org/obo/HP_0010644		
HP:0009648	biolink:PhenotypicFeature	Triangular shaped distal phalanx of the thumb	Triangular shaped distal phalanx of the thumb. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.	UMLS:C4024257	hp.json	Triangular shaped outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009648		
HP:0009643	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the thumb	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the distal phalanx of the thumb is affected.	UMLS:C4024260	hp.json	Bullet-shaped outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009643		
HP:0009642	biolink:PhenotypicFeature	Broad distal phalanx of the thumb	Increased width of the distal phalanx of thumb.	UMLS:C1863402	hp.json	Broad terminal thumb phalanx|Wide distal phalanx of thumb|Broad outermost bone of the thumb|Wide outermost bone of thumb	http://purl.obolibrary.org/obo/HP_0009642		
HP:0009645	biolink:PhenotypicFeature	Osteolytic defect of the distal phalanx of the thumb	Dissolution or degeneration of bone tissue of the distal phalanx of the thumb.	UMLS:C4021417	hp.json	Osteolytic defects of the distal phalanx of the thumb|Osteolytic defects of the outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009645		
HP:0009644	biolink:PhenotypicFeature	Curved distal phalanx of the thumb	A deviation from the normal straight shape of the distal phalanx of the thumb.	UMLS:C4024259	hp.json	Curved outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0009644		
GO:0001976	biolink:NamedThing	nervous system process involved in regulation of systemic arterial blood pressure			hp.json		http://purl.obolibrary.org/obo/GO_0001976		
GO:0001977	biolink:NamedThing	renal system process involved in regulation of blood volume			hp.json		http://purl.obolibrary.org/obo/GO_0001977		
HP:0009641	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the thumb		UMLS:C4024261	hp.json	Absent/small outermost thumb bone|Absent/underdeveloped outermost thumb bone	http://purl.obolibrary.org/obo/HP_0009641		
HP:0009640	biolink:PhenotypicFeature	Synostosis of the proximal phalanx of the thumb with the 1st metacarpal	Fusion of the proximal phalanx of the thumb with the 1st metacarpal.	UMLS:C4024262	hp.json	Ankylosis of the metacarpophalangeal joint of the thumb|Fusion of the innermost bone of the thumb with the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0009640		
UBERON:0002827	biolink:AnatomicalEntity	vestibulocochlear ganglion	The group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia.	EMAPA:16982|TAO:0000588|EHDAA:5569|EMAPA:17571|EHDAA:6653|XAO:0004142|MA:0001084|EFO:0003543|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=496|UMLS:C0037959|VHOG:0000696|EHDAA2:0002196|ZFA:0000588|BIRNLEX:2564	hp.json	vestibulocochlear ganglia|acoustico-vestibular VIII ganglion|gVIII|statoacoustic ganglion|nucleus nervi oculomotorii ventrolateralis|acoustic ganglion VIII|auditory ganglion|acoustic ganglion|statoacoustic VIII ganglion|nucleus nervi oculomotorii, pars ventralis|ganglion VIII|vestibulocochlear VIII ganglion|auditory ganglion|statoacoustic ganglia|statoacoustic (VIII) ganglion|SAG	http://purl.obolibrary.org/obo/UBERON_0002827		vertebrate_core|pheno_slim|efo_slim
UBERON:0002824	biolink:AnatomicalEntity	vestibular ganglion	The ganglion of the vestibular nerve. It contains the cell bodies of the bipolar primary afferent neurons whose peripheral processes form synaptic contact with hair cells of the vestibular sensory end organs[WP,unvetted]. Distributed to the maculae of the utricle and saccule and to the ampullary crests of the semicircular ducts. The vestibular fibers arise in bipolar cells in the vestibular ganglion in the internal acoustic meatus.	RETIRED_EHDAA2:0002199|UMLS:C0036286|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=495|EMAPA:17573|UMLS:C0446706|NCIT:C33870|FMA:53435|BAMS:GvVIII|MA:0001086|BIRNLEX:2549|VHOG:0000682|UMLS:C0036286	hp.json	vestibulocochlear ganglion vestibular component|Scarpa's ganglion|nucleus nervi oculomotorii, pars medialis|vestibular part of vestibulocochlear ganglion|vestibulocochlear VIII ganglion vestibular component	http://purl.obolibrary.org/obo/UBERON_0002824		pheno_slim|uberon_slim
HP:0010632	biolink:PhenotypicFeature	Total anosmia	Inability to detect any qualitative olfactory sensation.	UMLS:C4023768	hp.json		http://purl.obolibrary.org/obo/HP_0010632		
HP:0010631	biolink:PhenotypicFeature	Abnormality of the epiphyses of the feet	Any abnormality of the epiphyses of the feet.	UMLS:C4023769	hp.json	Abnormality of the end part of the foot bone	http://purl.obolibrary.org/obo/HP_0010631		
HP:0010630	biolink:PhenotypicFeature	Abnormality of metatarsal epiphysis	Any abnormality of a metatarsal bone epiphysis.	UMLS:C4021248	hp.json	Abnormality of the epiphyses of the metatarsals|Abnormality of end part of long bone of foot	http://purl.obolibrary.org/obo/HP_0010630		
HP:0010639	biolink:PhenotypicFeature	Elevated alkaline phosphatase of bone origin	An abnormally increased level of bone isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood.	UMLS:C1833667	hp.json	Elevated ALP of bone origin|Increased serum bone-specific alkaline phosphatase|Elevated alkaline phosphatase of bone origin	http://purl.obolibrary.org/obo/HP_0010639		
HP:0010638	biolink:PhenotypicFeature	Elevated alkaline phosphatase of hepatic origin	An abnormally increased level of liver isoforms of alkaline phosphatase, tissue-nonspecific isozyme in the blood.	UMLS:C4023764	hp.json	Elevated ALP of hepatic origin	http://purl.obolibrary.org/obo/HP_0010638		
HP:0010637	biolink:PhenotypicFeature	Conjunctival amyloidosis	A form of amyloidosis that affects the conjunctiva.	SNOMEDCT_US:59017008|UMLS:C0268402	hp.json		http://purl.obolibrary.org/obo/HP_0010637		
HP:0009658	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the thumb		UMLS:C4024256	hp.json	Absent/underdeveloped thumb bones|Absent/small thumb bones	http://purl.obolibrary.org/obo/HP_0009658		
HP:0010636	biolink:PhenotypicFeature	Schizencephaly	The presence of a cleft in the cerebral cortex unilaterally or bilaterally, usually located in the frontal area.	SNOMEDCT_US:38353004|MSH:D065707|SNOMEDCT_US:253159001|UMLS:C0266484	hp.json		http://purl.obolibrary.org/obo/HP_0010636		
HP:0010635	biolink:PhenotypicFeature	Partial hyposmia	Reduced ability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants).	UMLS:C4023765	hp.json		http://purl.obolibrary.org/obo/HP_0010635		
HP:0009657	biolink:PhenotypicFeature	Triangular shaped thumb phalanx	Abnormal shape of one or more phalanges of the thumb such that affected phalanges resemble a triangle.	UMLS:C4021412	hp.json	Triangular thumb phalanges|Triangular shaped phalanges of the thumb|Triangular shaped thumb bone	http://purl.obolibrary.org/obo/HP_0009657		
HP:0010634	biolink:PhenotypicFeature	Total hyposmia	Reduced ability to detect any qualitative olfactory sensation.	UMLS:C4023766	hp.json		http://purl.obolibrary.org/obo/HP_0010634		
HP:0010633	biolink:PhenotypicFeature	Partial anosmia	Inability to perceive certain odorants (implies that the sense of smell is maintained for other classes of odorants).	UMLS:C4023767	hp.json		http://purl.obolibrary.org/obo/HP_0010633		
HP:0009659	biolink:PhenotypicFeature	Partial absence of thumb	The absence of a phalangeal segment of a thumb.	UMLS:C4020780|UMLS:C4024255	hp.json	Partial absence of thumb|Aplasia of the phalanges of the thumb	http://purl.obolibrary.org/obo/HP_0009659		
HP:0009654	biolink:PhenotypicFeature	Osteolytic defect of thumb phalanx	Dissolution or degeneration of bone tissue of one or more phalanges of the thumb.	UMLS:C4020905	hp.json	Osteolytic defects of the phalanges of the thumb	http://purl.obolibrary.org/obo/HP_0009654		
HP:0009653	biolink:PhenotypicFeature	Curved thumb phalanx	A deviation from the normal straight shape of a thumb phalanx.	UMLS:C4021414	hp.json	Curved phalanges of the thumb|Curved thumb bone	http://purl.obolibrary.org/obo/HP_0009653		
HP:0009656	biolink:PhenotypicFeature	Symphalangism of the thumb	Congenital fusion (ankylosis) of the interphalangeal joint of the thumb.	UMLS:C1834032	hp.json	Fused thumb bones|Symphalangism of the distal and proximal phalanges of the thumb|Fused thumb phalanges	http://purl.obolibrary.org/obo/HP_0009656		
HP:0009655	biolink:PhenotypicFeature	Patchy sclerosis of thumb phalanx	An uneven increase in bone density of one or more of the phalanges of the thumb.	UMLS:C4021413	hp.json	Uneven increase in bone density in thumb bone|Patchy sclerosis of the phalanges of the thumb	http://purl.obolibrary.org/obo/HP_0009655		
HP:0009650	biolink:PhenotypicFeature	Short distal phalanx of the thumb	Hypoplastic (short) distal phalanx of the thumb.	UMLS:C1862313	hp.json	Small terminal thumb phalanx|Short thumb terminal phalanx|Short terminal thumb phalanx|Short outermost bone of the thumb|Hypoplastic/small distal phalanx of the thumb|Hypoplastic terminal thumb phalanx	http://purl.obolibrary.org/obo/HP_0009650		
HP:0009652	biolink:PhenotypicFeature	Bullet-shaped thumb phalanx	An abnormal morphology of one or more phalanges of the thumb, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021415	hp.json	Bullet-shaped phalanges of the thumb|Bullet-shaped thumb bone	http://purl.obolibrary.org/obo/HP_0009652		
UBERON:0002812	biolink:AnatomicalEntity	left cerebral hemisphere	A cerebral hemisphere that is in the left side of a brain.	SCTID:362323007|FMA:61819|NCIT:C32955|BIRNLEX:1795|UMLS:C0228176	hp.json	left hemisphere	http://purl.obolibrary.org/obo/UBERON_0002812		
UBERON:0002811	biolink:AnatomicalEntity	left frontal lobe	A frontal cortex that is part of a left cerebral hemisphere.	FMA:72970|UMLS:C1281955|BIRNLEX:1787	hp.json		http://purl.obolibrary.org/obo/UBERON_0002811		
UBERON:0002813	biolink:AnatomicalEntity	right cerebral hemisphere	A cerebral hemisphere that is in the right side of a brain.	FMA:67292|NCIT:C33472|SCTID:362322002|UMLS:C0228175|BIRNLEX:1797|OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvigx5ZwpEbGdrcN5Y29ycA	hp.json	right hemisphere	http://purl.obolibrary.org/obo/UBERON_0002813		
HP:0010621	biolink:PhenotypicFeature	Cutaneous syndactyly of toes	A soft tissue continuity in the anteroposterior axis between adjacent foot digits that involves at least half of the proximodistal length of one of the two involved digits; or, a soft tissue continuity in the A/P axis between two digits of the foot that does not meet the prior objective criteria.	UMLS:C1834737	hp.json	Cutaneous syndactyly of feet|Webbed skin of toes|soft tissue syndactyly of toes	http://purl.obolibrary.org/obo/HP_0010621		hposlim_core
HP:0010620	biolink:PhenotypicFeature	Malar prominence	Prominence of the malar process of the maxilla and infraorbital area appreciated in profile and from in front of the face.	UMLS:C4280374|UMLS:C1858732	hp.json	Prominent malar region|Malar excess|Hyperplasia of malar bones|Malar hyperplasia	http://purl.obolibrary.org/obo/HP_0010620		hposlim_core
HP:0009629	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the proximal phalanx of the thumb	This term applies if the proximal phalanx of the thumb is either small/hypoplastic or absent. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024268	hp.json	Absent/small innermost thumb bone|Absent/underdeveloped innermost thumb bone	http://purl.obolibrary.org/obo/HP_0009629		
HP:0010629	biolink:PhenotypicFeature	Abnormal morphology of the cortex of the humerus	Any abnormality affecting the cortex of the humerus.	UMLS:C4023770	hp.json		http://purl.obolibrary.org/obo/HP_0010629		
HP:0010628	biolink:PhenotypicFeature	Facial palsy	Facial nerve palsy is a dysfunction of cranial nerve VII (the facial nerve) that results in inability to control facial muscles on the affected side with weakness of the muscles of facial expression and eye closure. This can either be present in unilateral or bilateral form.	UMLS:C0376175|SNOMEDCT_US:95666008|SNOMEDCT_US:193093009|UMLS:C0427055|MSH:D020330|UMLS:C1858719|MSH:D005158	hp.json	Facial muscle weakness of muscles innervated by CN VII|Facial nerve palsy|Bell's palsy|Facial nerve paralysis|Seventh cranial nerve palsy|VII th cranial nerve palsy|Facial palsy, unilateral or bilateral|Cranial nerve VII palsy	http://purl.obolibrary.org/obo/HP_0010628		hposlim_core
HP:0010627	biolink:PhenotypicFeature	Anterior pituitary hypoplasia	Underdevelopment of the anterior pituitary gland.	UMLS:C1859775|UMLS:C0948740	hp.json	Underdeveloped pituitary gland|Hypoplasia of the pituitary gland	http://purl.obolibrary.org/obo/HP_0010627		
HP:0010626	biolink:PhenotypicFeature	Anterior pituitary agenesis	Absence of the anterior pituitary gland resulting from a developmental defect.	UMLS:C4021249	hp.json	Absent pituitary gland|Aplasia of the pituitary gland	http://purl.obolibrary.org/obo/HP_0010626		
HP:0010625	biolink:PhenotypicFeature	Anterior pituitary dysgenesis	Absence or underdevelopment of the anterior pituitary gland, also known as the adenohypophysis.	SNOMEDCT_US:62818001|UMLS:C0032008|UMLS:C4023771|MSH:D010903	hp.json	Adenohypophysis	http://purl.obolibrary.org/obo/HP_0010625		
HP:0009625	biolink:PhenotypicFeature	Contractures of the metacarpophalangeal joint of the thumb	Chronic loss of joint motion of the metacarpophalangeal joint of the thumb due to structural changes in non-bony tissue. This joint is also called Articulatio metacarpophalangealis pollicis.	UMLS:C2108151	hp.json		http://purl.obolibrary.org/obo/HP_0009625		
HP:0010624	biolink:PhenotypicFeature	Aplastic/hypoplastic toenail	Absence or underdevelopment of the toenail.	UMLS:C1856749	hp.json	Aplastic/hypoplastic toenails|Absent/underdeveloped toenails|Hypoplastic-absent toenails|Absent/small toenails	http://purl.obolibrary.org/obo/HP_0010624		
HP:0009624	biolink:PhenotypicFeature	Contractures of the carpometacarpal joint of the thumb	Chronic loss of joint motion of the carpometacarpal joint of the thumb due to structural changes in non-bony tissue. This joint is formed by the first metacarpal and the trapezial bone and is also called Articulatio carpometacarpalis pollicis, carpometacarpal articulation of thumb, carpometacarpal joint of thumb or first carpometacarpal articulation. Seldom referred to as thumb saddle joint.	UMLS:C4024269	hp.json		http://purl.obolibrary.org/obo/HP_0009624		
HP:0010622	biolink:PhenotypicFeature	Neoplasm of the skeletal system	A tumor (abnormal growth of tissue) of the skeleton.	NCIT:C3262|UMLS:C2732838|UMLS:C4020771|SNOMEDCT_US:442868003	hp.json	Neoplasia of the skeletal system|Skeletal tumor|Bone neoplasm|Skeletal tumour	http://purl.obolibrary.org/obo/HP_0010622		
HP:0009626	biolink:PhenotypicFeature	Contractures of the interphalangeal joint of the thumb	Chronic loss of joint motion of the interphalangeal joint of the thumb due to structural changes in non-bony tissue. This joint is also called Articulatio interphalangealis pollicis.	UMLS:C2108146	hp.json	Interphalangeal extension contractures of thumbs	http://purl.obolibrary.org/obo/HP_0009626		
GO:0001958	biolink:BiologicalProcess	endochondral ossification	Replacement ossification wherein bone tissue replaces cartilage.	Wikipedia:Endochondral_ossification	hp.json		http://purl.obolibrary.org/obo/GO_0001958		
HP:0009621	biolink:PhenotypicFeature	obsolete Ulnar deviation of the thumb			hp.json		http://purl.obolibrary.org/obo/HP_0009621		
GO:0001959	biolink:BiologicalProcess	regulation of cytokine-mediated signaling pathway	Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.		hp.json	regulation of cytokine mediated signalling pathway|regulation of cytokine and chemokine mediated signaling pathway|regulation of cytokine mediated signaling pathway	http://purl.obolibrary.org/obo/GO_0001959		
HP:0009620	biolink:PhenotypicFeature	obsolete Radial deviation of the thumb			hp.json		http://purl.obolibrary.org/obo/HP_0009620		
HP:0009623	biolink:PhenotypicFeature	Proximal placement of thumb	Proximal mislocalization of the thumb.	UMLS:C1865572	hp.json	Proximally placed thumbs|Low implantation of the thumb|Attachment of thumb close to wrist|Low-set thumb	http://purl.obolibrary.org/obo/HP_0009623		hposlim_core
HP:0009622	biolink:PhenotypicFeature	Distally placed thumb	Insertion of thumb at a more distal location than normal.	UMLS:C4024270	hp.json		http://purl.obolibrary.org/obo/HP_0009622		
GO:0001955	biolink:BiologicalProcess	blood vessel maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.		hp.json		http://purl.obolibrary.org/obo/GO_0001955		
GO:0001957	biolink:BiologicalProcess	intramembranous ossification	Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.	Wikipedia:Intramembranous_ossification	hp.json	dermal ossification|intramembranous bone ossification	http://purl.obolibrary.org/obo/GO_0001957		
UBERON:0002805	biolink:AnatomicalEntity	right limbic lobe	A limbic lobe that is part of a right cerebral hemisphere.	BIRNLEX:1781|FMA:72980	hp.json		http://purl.obolibrary.org/obo/UBERON_0002805		
GO:0001961	biolink:BiologicalProcess	positive regulation of cytokine-mediated signaling pathway	Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.		hp.json	positive regulation of cytokine mediated signalling pathway|up-regulation of cytokine mediated signaling pathway|positive regulation of cytokine and chemokine mediated signaling pathway|up regulation of cytokine mediated signaling pathway|activation of cytokine mediated signaling pathway|stimulation of cytokine mediated signaling pathway|upregulation of cytokine mediated signaling pathway|positive regulation of cytokine mediated signaling pathway	http://purl.obolibrary.org/obo/GO_0001961		
UBERON:0002804	biolink:AnatomicalEntity	left limbic lobe	A limbic lobe that is part of a left cerebral hemisphere.	BIRNLEX:1780|FMA:72981	hp.json		http://purl.obolibrary.org/obo/UBERON_0002804		
GO:0001964	biolink:BiologicalProcess	startle response	An action or movement due to the application of a sudden unexpected stimulus.	Wikipedia:Startle_reaction	hp.json		http://purl.obolibrary.org/obo/GO_0001964		
UBERON:0002803	biolink:AnatomicalEntity	right parietal lobe	Parietal lobe of the right hemisphere of the brain.	BIRNLEX:1729|FMA:72973|UMLS:C1281959	hp.json		http://purl.obolibrary.org/obo/UBERON_0002803		
GO:0001960	biolink:BiologicalProcess	negative regulation of cytokine-mediated signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.		hp.json	down regulation of cytokine mediated signaling pathway|negative regulation of cytokine mediated signaling pathway|inhibition of cytokine mediated signaling pathway|downregulation of cytokine mediated signaling pathway|negative regulation of cytokine and chemokine mediated signaling pathway|down-regulation of cytokine mediated signaling pathway|negative regulation of cytokine mediated signalling pathway	http://purl.obolibrary.org/obo/GO_0001960		
UBERON:0002802	biolink:AnatomicalEntity	left parietal lobe	Parietal lobe of the left hemisphere of the brain.	FMA:72974|BIRNLEX:1728|UMLS:C1281960	hp.json		http://purl.obolibrary.org/obo/UBERON_0002802		
HP:0010610	biolink:PhenotypicFeature	Palmar pits		UMLS:C0423776|SNOMEDCT_US:247449001	hp.json		http://purl.obolibrary.org/obo/HP_0010610		
CHEBI:25481	biolink:ChemicalSubstance	naphthoquinone	A polycyclic aromatic ketone metabolite of naphthalene.		hp.json	naphthoquinones	http://purl.obolibrary.org/obo/CHEBI_25481		3_STAR
UBERON:0002809	biolink:AnatomicalEntity	right temporal lobe	A temporal lobe that is part of a right cerebral hemisphere.	BIRNLEX:1785|UMLS:C1281970|OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rwQLi-ZwpEbGdrcN5Y29ycA|FMA:72971	hp.json		http://purl.obolibrary.org/obo/UBERON_0002809		
UBERON:0002808	biolink:AnatomicalEntity	left temporal lobe	A temporal lobe that is part of a left cerebral hemisphere.	UMLS:C1281971|BIRNLEX:1784|FMA:72972|OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rwQLi-ZwpEbGdrcN5Y29ycA	hp.json		http://purl.obolibrary.org/obo/UBERON_0002808		
HP:0010618	biolink:PhenotypicFeature	Ovarian fibroma	The presence of a fibroma of the ovary.	UMLS:C0149951|MSH:C562391|NCIT:C3041|SNOMEDCT_US:254865006	hp.json		http://purl.obolibrary.org/obo/HP_0010618		
HP:0010617	biolink:PhenotypicFeature	Cardiac fibroma	A fibroma of the heart.	NCIT:C3041|UMLS:C1096654	hp.json		http://purl.obolibrary.org/obo/HP_0010617		
HP:0010616	biolink:PhenotypicFeature	Lung fibroma	The presence of a lung fibroma, a benign neoplasm that can present as a mass causing airway obstruction, cough, and hemoptysis, or present without symptoms as a solitary pulmonary nodule.	NCIT:C3041|SNOMEDCT_US:707387004|UMLS:C1334444	hp.json		http://purl.obolibrary.org/obo/HP_0010616		
HP:0010615	biolink:PhenotypicFeature	Angiofibromas	Angiofibroma consist of many often dilated vessels.	MSH:D018322|SNOMEDCT_US:302857002|SNOMEDCT_US:60392001|UMLS:C0206731|NCIT:C3799	hp.json		http://purl.obolibrary.org/obo/HP_0010615		
HP:0009636	biolink:PhenotypicFeature	Triangular shaped proximal phalanx of the thumb	Triangular shaped proximal phalanx of the thumb.	UMLS:C4021419	hp.json	Triangular innermost thumb bone|Triangular proximal thumb phalanx	http://purl.obolibrary.org/obo/HP_0009636		
HP:0010614	biolink:PhenotypicFeature	Fibroma	Benign tumors that are composed of fibrous or connective tissue. They can grow in all organs, arising from mesenchyme tissue. The term "fibroblastic" or "fibromatous" is used to describe tumors of the fibrous connective tissue. When the term fibroma is used without modifier, it is usually considered benign, with the term fibrosarcoma reserved for malignant tumors.	MSH:D005350|SNOMEDCT_US:112682009|UMLS:C0016045|NCIT:C3041|SNOMEDCT_US:424568000	hp.json		http://purl.obolibrary.org/obo/HP_0010614		
HP:0009635	biolink:PhenotypicFeature	Synostosis of thumb phalanx	Fusion of a phalanx of the thumb with another bone.	UMLS:C4024263	hp.json	Fusion of thumb bone	http://purl.obolibrary.org/obo/HP_0009635		
HP:0009638	biolink:PhenotypicFeature	Short proximal phalanx of thumb	Hypoplastic (short) proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C1855091	hp.json	Short proximal thumb phalanx|Short proximal phalanges of thumb|Short proximal thumb bone|Hypoplastic/small proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009638		
HP:0010612	biolink:PhenotypicFeature	Plantar pits	The presence of multiple pits (small, pinpoint-large indentations on the surface of the skin) located on the skin of sole of foot.	UMLS:C1852301	hp.json		http://purl.obolibrary.org/obo/HP_0010612		
HP:0009637	biolink:PhenotypicFeature	Absent proximal phalanx of thumb	Absence of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4021418	hp.json	Aplasia of the proximal phalanx of the thumb|Absent ossification/absent proximal thumb phalanx|Absent innermost thumb bone	http://purl.obolibrary.org/obo/HP_0009637		
HP:0009632	biolink:PhenotypicFeature	Curved proximal phalanx of the thumb	A deviation from the normal straight shape of the proximal phalanx of the thumb.	UMLS:C4024265	hp.json	Curved innermost thumb bone	http://purl.obolibrary.org/obo/HP_0009632		
HP:0009631	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the thumb	Bullet-shaped phalanx refers to a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction. This term is used if the proximal phalanx of the thumb is affected.	UMLS:C4024266	hp.json	Bullet-shaped innermost thumb bone	http://purl.obolibrary.org/obo/HP_0009631		
HP:0009634	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the thumb	An uneven increase in bone density of the proximal phalanx of the thumb.	UMLS:C4024264	hp.json	Uneven increase in bone density in the innermost thumb bone	http://purl.obolibrary.org/obo/HP_0009634		
UBERON:0002810	biolink:AnatomicalEntity	right frontal lobe	A frontal cortex that is part of a right cerebral hemisphere.	UMLS:C1281954|BIRNLEX:1786|FMA:72969	hp.json		http://purl.obolibrary.org/obo/UBERON_0002810		
HP:0009633	biolink:PhenotypicFeature	Osteolytic defect of the proximal phalanx of the thumb	Dissolution or degeneration of bone tissue of the proximal phalanx of the thumb.	UMLS:C4021420	hp.json	Osteolytic defects of the proximal phalanx of the thumb	http://purl.obolibrary.org/obo/HP_0009633		
HP:0009630	biolink:PhenotypicFeature	Broad proximal phalanx of the thumb	Increased width of the proximal phalanx of the thumb. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024267	hp.json	Broad innermost thumb bone	http://purl.obolibrary.org/obo/HP_0009630		
HP:0010619	biolink:PhenotypicFeature	Fibroadenoma of the breast	A benign biphasic tumor of the breast with epithelial and stromal components.	UMLS:C0178421|SNOMEDCT_US:254845004|NCIT:C3744	hp.json	Fibroadenosis - breast|Breast fibroadenomas|Breast fibroadenosis|Breast fibroadenoma|Fibroadenosis of breast	http://purl.obolibrary.org/obo/HP_0010619		
GO:0098840	biolink:BiologicalProcess	protein transport along microtubule	The directed movement of a protein along a microtubule, mediated by motor proteins.		hp.json	microtubule-based protein transport	http://purl.obolibrary.org/obo/GO_0098840		
CL:0002548	biolink:Cell	fibroblast of cardiac tissue	A fibroblast that is part of the heart.		hp.json	cardiac fibroblast	http://purl.obolibrary.org/obo/CL_0002548		
CL:0002547	biolink:Cell	fibroblast of the aortic adventitia	A fibroblast of the aortic adventitia.		hp.json		http://purl.obolibrary.org/obo/CL_0002547		
GO:1902652	biolink:BiologicalProcess	secondary alcohol metabolic process	The chemical reactions and pathways involving secondary alcohol.		hp.json	secondary alcohol metabolism	http://purl.obolibrary.org/obo/GO_1902652		
GO:0060231	biolink:BiologicalProcess	mesenchymal to epithelial transition	A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell.		hp.json	mesenchymal-epithelial transition|epithelial cell differentiation from mesenchymal cell	http://purl.obolibrary.org/obo/GO_0060231		
CL:0002540	biolink:Cell	mesenchymal stem cell of the bone marrow	A mesenchymal stem cell that is part of the bone marrow.		hp.json		http://purl.obolibrary.org/obo/CL_0002540		
GO:0035265	biolink:BiologicalProcess	organ growth	The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.		hp.json		http://purl.obolibrary.org/obo/GO_0035265		
CL:0002541	biolink:Cell	chorionic membrane mesenchymal stem cell	A mesenchymal stem cell of the chorionic membrane.		hp.json		http://purl.obolibrary.org/obo/CL_0002541		
CL:0002543	biolink:Cell	vein endothelial cell	An endothelial cell that is part of the vein.	KUPO:0001099|FMA:62104	hp.json	venous endothelial cell|endothelial cell of vein	http://purl.obolibrary.org/obo/CL_0002543		
CL:0002546	biolink:Cell	embryonic blood vessel endothelial progenitor cell	An endothelial progenitor cell that participates in angiogenesis during development.		hp.json		http://purl.obolibrary.org/obo/CL_0002546		
GO:0035260	biolink:BiologicalProcess	internal genitalia morphogenesis	The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.		hp.json		http://purl.obolibrary.org/obo/GO_0035260		
GO:0035261	biolink:BiologicalProcess	external genitalia morphogenesis	The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals.		hp.json		http://purl.obolibrary.org/obo/GO_0035261		
GO:0035262	biolink:BiologicalProcess	gonad morphogenesis	The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.		hp.json		http://purl.obolibrary.org/obo/GO_0035262		
GO:0035264	biolink:BiologicalProcess	multicellular organism growth	The increase in size or mass of an entire multicellular organism, as opposed to cell growth.		hp.json	body growth	http://purl.obolibrary.org/obo/GO_0035264		
GO:0098852	biolink:CellularComponent	lytic vacuole membrane	The lipid bilayer surrounding a lytic vacuole and separating its contents from the cytoplasm of the cell.		hp.json		http://purl.obolibrary.org/obo/GO_0098852		
GO:2001204	biolink:BiologicalProcess	regulation of osteoclast development	Any process that modulates the frequency, rate or extent of osteoclast development.		hp.json	regulation of osteoclast cell development	http://purl.obolibrary.org/obo/GO_2001204		
CL:0002559	biolink:Cell	hair follicle cell	An animal cell that is part of a hair follicle.		hp.json		http://purl.obolibrary.org/obo/CL_0002559		
GO:2001205	biolink:BiologicalProcess	negative regulation of osteoclast development	Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.		hp.json	negative regulation of osteoclast cell development	http://purl.obolibrary.org/obo/GO_2001205		
GO:2001206	biolink:BiologicalProcess	positive regulation of osteoclast development	Any process that activates or increases the frequency, rate or extent of osteoclast development.		hp.json	positive regulation of osteoclast cell development	http://purl.obolibrary.org/obo/GO_2001206		
CL:0002551	biolink:Cell	fibroblast of dermis			hp.json		http://purl.obolibrary.org/obo/CL_0002551		
GO:0060221	biolink:BiologicalProcess	retinal rod cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a retinal rod cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060221		
CL:0002553	biolink:Cell	fibroblast of lung	A fibroblast that is part of lung.	BTO:0000764|CALOHA:TS-0575	hp.json		http://purl.obolibrary.org/obo/CL_0002553		
GO:2001200	biolink:BiologicalProcess	positive regulation of dendritic cell differentiation	Any process that activates or increases the frequency, rate or extent of dendritic cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_2001200		
CL:0002557	biolink:Cell	fibroblast of pulmonary artery	A fibroblast of pulmonary artery.		hp.json		http://purl.obolibrary.org/obo/CL_0002557		
GO:0098858	biolink:NamedThing	actin-based cell projection			hp.json		http://purl.obolibrary.org/obo/GO_0098858		
GO:0072201	biolink:BiologicalProcess	negative regulation of mesenchymal cell proliferation	Any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.		hp.json		http://purl.obolibrary.org/obo/GO_0072201		
GO:0106214	biolink:BiologicalProcess	regulation of vesicle fusion with Golgi apparatus	Any process that modulates the frequency, rate or extent of vesicle fusion with Golgi apparatus.		hp.json		http://purl.obolibrary.org/obo/GO_0106214		
GO:1900015	biolink:BiologicalProcess	regulation of cytokine production involved in inflammatory response	Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.		hp.json	regulation of cytokine production involved in acute inflammatory response	http://purl.obolibrary.org/obo/GO_1900015		
GO:1902679	biolink:BiologicalProcess	negative regulation of RNA biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process.		hp.json	inhibition of RNA biosynthetic process|inhibition of RNA biosynthesis|negative regulation of RNA biosynthesis|down-regulation of RNA biosynthesis|down regulation of RNA formation|down-regulation of RNA biosynthetic process|inhibition of RNA synthesis|downregulation of RNA synthesis|inhibition of RNA formation|downregulation of RNA formation|down-regulation of RNA anabolism|negative regulation of RNA anabolism|downregulation of RNA biosynthesis|downregulation of RNA biosynthetic process|down regulation of RNA anabolism|down-regulation of RNA synthesis|negative regulation of RNA synthesis|down regulation of RNA biosynthesis|down regulation of RNA biosynthetic process|down-regulation of RNA formation|inhibition of RNA anabolism|downregulation of RNA anabolism|negative regulation of RNA formation|down regulation of RNA synthesis	http://purl.obolibrary.org/obo/GO_1902679		
GO:1900017	biolink:BiologicalProcess	positive regulation of cytokine production involved in inflammatory response	Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.		hp.json	up regulation of cytokine production involved in acute inflammatory response|positive regulation of cytokine production involved in acute inflammatory response|up regulation of cytokine production involved in inflammatory response	http://purl.obolibrary.org/obo/GO_1900017		
GO:0106216	biolink:BiologicalProcess	positive regulation of vesicle fusion with Golgi apparatus	Any process that activates or increases the frequency, rate or extent of vesicle fusion with Golgi apparatus.		hp.json		http://purl.obolibrary.org/obo/GO_0106216		
GO:1900016	biolink:BiologicalProcess	negative regulation of cytokine production involved in inflammatory response	Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.		hp.json	negative regulation of cytokine production involved in acute inflammatory response|down regulation of cytokine production involved in inflammatory response|down regulation of cytokine production involved in acute inflammatory response	http://purl.obolibrary.org/obo/GO_1900016		
GO:0106215	biolink:BiologicalProcess	negative regulation of vesicle fusion with Golgi apparatus	Any process that stops, prevents or reduces the frequency, rate or extent of vesicle fustion with Golgi apparatus.		hp.json		http://purl.obolibrary.org/obo/GO_0106215		
GO:0060251	biolink:BiologicalProcess	regulation of glial cell proliferation	Any process that modulates the frequency, rate or extent of glial cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0060251		
GO:0060252	biolink:BiologicalProcess	positive regulation of glial cell proliferation	Any process that activates or increases the rate or extent of glial cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0060252		
GO:0060253	biolink:BiologicalProcess	negative regulation of glial cell proliferation	Any process that stops or decreases the rate or extent of glial cell proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_0060253		
GO:0060255	biolink:BiologicalProcess	regulation of macromolecule metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.		hp.json		http://purl.obolibrary.org/obo/GO_0060255		
GO:1902680	biolink:BiologicalProcess	positive regulation of RNA biosynthetic process	Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process.		hp.json	upregulation of RNA anabolism|up regulation of RNA biosynthesis|up regulation of RNA biosynthetic process|activation of RNA synthesis|positive regulation of RNA synthesis|up regulation of RNA formation|up-regulation of RNA biosynthesis|up-regulation of RNA biosynthetic process|activation of RNA formation|positive regulation of RNA formation|upregulation of RNA synthesis|activation of RNA biosynthesis|activation of RNA biosynthetic process|upregulation of RNA formation|up-regulation of RNA anabolism|up regulation of RNA anabolism|upregulation of RNA biosynthesis|upregulation of RNA biosynthetic process|up-regulation of RNA synthesis|activation of RNA anabolism|positive regulation of RNA anabolism|up regulation of RNA synthesis|up-regulation of RNA formation|positive regulation of RNA biosynthesis	http://purl.obolibrary.org/obo/GO_1902680		
CL:0002521	biolink:Cell	subcutaneous fat cell	A fat cell that is part of subcutaneous adipose tissue.		hp.json	subcutaneous adipocyte	http://purl.obolibrary.org/obo/CL_0002521		
GO:2001212	biolink:BiologicalProcess	regulation of vasculogenesis	Any process that modulates the frequency, rate or extent of vasculogenesis.		hp.json	regulation of vascular morphogenesis	http://purl.obolibrary.org/obo/GO_2001212		
GO:0060259	biolink:BiologicalProcess	regulation of feeding behavior	Any process that modulates the rate, frequency or extent of the behavior associated with the intake of food.		hp.json	regulation of feeding behaviour	http://purl.obolibrary.org/obo/GO_0060259		
GO:2001213	biolink:BiologicalProcess	negative regulation of vasculogenesis	Any process that stops, prevents or reduces the frequency, rate or extent of vasculogenesis.		hp.json	negative regulation of vascular morphogenesis	http://purl.obolibrary.org/obo/GO_2001213		
GO:2001214	biolink:BiologicalProcess	positive regulation of vasculogenesis	Any process that activates or increases the frequency, rate or extent of vasculogenesis.		hp.json	positive regulation of vascular morphogenesis	http://purl.obolibrary.org/obo/GO_2001214		
GO:0035240	biolink:MolecularActivity	dopamine binding	Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine.		hp.json		http://purl.obolibrary.org/obo/GO_0035240		
CL:0002539	biolink:Cell	aortic smooth muscle cell	A smooth muscle cell of the aorta.	BTO:0004577	hp.json		http://purl.obolibrary.org/obo/CL_0002539		
GO:1902685	biolink:BiologicalProcess	positive regulation of receptor localization to synapse	Any process that activates or increases the frequency, rate or extent of receptor localization to synapse.		hp.json	up regulation of receptor localization to synapse|upregulation of receptor localisation to synapse|activation of receptor localization to synapse|up-regulation of receptor localization to synapse|positive regulation of receptor localisation to synapse|up regulation of receptor localisation to synapse|up-regulation of receptor localisation to synapse|upregulation of receptor localization to synapse|activation of receptor localisation to synapse	http://purl.obolibrary.org/obo/GO_1902685		
GO:1902683	biolink:BiologicalProcess	regulation of receptor localization to synapse	Any process that modulates the frequency, rate or extent of receptor localization to synapse.		hp.json	regulation of receptor localisation to synapse	http://purl.obolibrary.org/obo/GO_1902683		
GO:1902684	biolink:BiologicalProcess	negative regulation of receptor localization to synapse	Any process that stops, prevents or reduces the frequency, rate or extent of receptor localization to synapse.		hp.json	down regulation of receptor localisation to synapse|inhibition of receptor localisation to synapse|down-regulation of receptor localisation to synapse|negative regulation of receptor localisation to synapse|downregulation of receptor localization to synapse|down regulation of receptor localization to synapse|inhibition of receptor localization to synapse|down-regulation of receptor localization to synapse|downregulation of receptor localisation to synapse	http://purl.obolibrary.org/obo/GO_1902684		
GO:1902692	biolink:BiologicalProcess	regulation of neuroblast proliferation	Any process that modulates the frequency, rate or extent of neuroblast proliferation.		hp.json		http://purl.obolibrary.org/obo/GO_1902692		
GO:0035234	biolink:BiologicalProcess	ectopic germ cell programmed cell death	Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.		hp.json	programmed cell death, ectopic germ cells|programmed cell death of ectopic germ cells	http://purl.obolibrary.org/obo/GO_0035234		
GO:2001222	biolink:BiologicalProcess	regulation of neuron migration	Any process that modulates the frequency, rate or extent of neuron migration.		hp.json	regulation of neuronal migration|regulation of neuron chemotaxis|regulation of neuron guidance	http://purl.obolibrary.org/obo/GO_2001222		
GO:2001223	biolink:BiologicalProcess	negative regulation of neuron migration	Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.		hp.json	negative regulation of neuron chemotaxis|negative regulation of neuron guidance|negative regulation of neuronal migration	http://purl.obolibrary.org/obo/GO_2001223		
GO:2001224	biolink:BiologicalProcess	positive regulation of neuron migration	Any process that activates or increases the frequency, rate or extent of neuron migration.		hp.json	positive regulation of neuron guidance|positive regulation of neuronal migration|positive regulation of neuron chemotaxis	http://purl.obolibrary.org/obo/GO_2001224		
GO:0060249	biolink:BiologicalProcess	anatomical structure homeostasis	A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.		hp.json	anatomical structure maintenance	http://purl.obolibrary.org/obo/GO_0060249		
GO:0035239	biolink:BiologicalProcess	tube morphogenesis	The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.		hp.json		http://purl.obolibrary.org/obo/GO_0035239		
UBERON:0036291	biolink:AnatomicalEntity	myocardium of anterior wall of right ventricle		FMA:260877	hp.json		http://purl.obolibrary.org/obo/UBERON_0036291		
UBERON:0036290	biolink:AnatomicalEntity	myocardium of anterior wall of left ventricle		FMA:87177	hp.json		http://purl.obolibrary.org/obo/UBERON_0036290		
UBERON:0036293	biolink:AnatomicalEntity	oral frenulum	A small fold of mucous membrane in the mouth, connecting either the tongue or the lip to the mouth mucosa.		hp.json	oral frenum|oral frenula|frenulum|oral frenulum	http://purl.obolibrary.org/obo/UBERON_0036293		
GO:0098883	biolink:BiologicalProcess	synapse pruning	A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.		hp.json	synapse clearance|synapse removal|synapse elimination|synapse disassembly	http://purl.obolibrary.org/obo/GO_0098883		goslim_synapse
UBERON:0036295	biolink:AnatomicalEntity	renal pelvis/ureter	The upper tract of the renal system. The renal pelvis is the large cavity in the middle of each kidney. Urine drains from each kidney through a long tube called the ureter, into the bladder, where it is stored until it is passed from the body through the urethra.	NCIT:C54419	hp.json	renal pelvis and ureter|renal pelvis plus ureter	http://purl.obolibrary.org/obo/UBERON_0036295		
UBERON:0036294	biolink:AnatomicalEntity	mucosa of lip	A mucosa that is part of a lip region [Automatically generated definition].	NCIT:C12226	hp.json	labial mucosa	http://purl.obolibrary.org/obo/UBERON_0036294		
CL:0002504	biolink:Cell	enteric smooth muscle cell	A smooth muscle cell of the intestine.		hp.json	intestinal smooth muscle cell	http://purl.obolibrary.org/obo/CL_0002504		
CL:0002503	biolink:Cell	adventitial cell	A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc	BTO:0002441|FMA:84639	hp.json		http://purl.obolibrary.org/obo/CL_0002503		
GO:0060271	biolink:BiologicalProcess	cilium assembly	The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.	Reactome:R-HSA-5617833.2	hp.json	cilium morphogenesis|cilium organization|microtubule-based flagellum assembly|cilium biogenesis|cilium formation|ciliogenesis	http://purl.obolibrary.org/obo/GO_0060271		
GO:1900048	biolink:BiologicalProcess	positive regulation of hemostasis	Any process that activates or increases the frequency, rate or extent of hemostasis.		hp.json	up-regulation of hemostasis|activation of hemostasis|upregulation of hemostasis|up regulation of hemostasis	http://purl.obolibrary.org/obo/GO_1900048		
GO:1900047	biolink:BiologicalProcess	negative regulation of hemostasis	Any process that stops, prevents or reduces the frequency, rate or extent of hemostasis.		hp.json	downregulation of hemostasis|down regulation of hemostasis|inhibition of hemostasis|down-regulation of hemostasis	http://purl.obolibrary.org/obo/GO_1900047		
CL:0002518	biolink:Cell	kidney epithelial cell	An epithelial cell of the kidney.	KUPO:0001019	hp.json		http://purl.obolibrary.org/obo/CL_0002518		
GO:1900046	biolink:BiologicalProcess	regulation of hemostasis	Any process that modulates the frequency, rate or extent of hemostasis.		hp.json		http://purl.obolibrary.org/obo/GO_1900046		
GO:0060263	biolink:BiologicalProcess	regulation of respiratory burst	Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.		hp.json		http://purl.obolibrary.org/obo/GO_0060263		
GO:0060264	biolink:BiologicalProcess	regulation of respiratory burst involved in inflammatory response	Any process that modulates the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.		hp.json	regulation of respiratory burst involved in acute inflammatory response	http://purl.obolibrary.org/obo/GO_0060264		
GO:0060265	biolink:BiologicalProcess	positive regulation of respiratory burst involved in inflammatory response	Any process that increases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.		hp.json	positive regulation of respiratory burst involved in acute inflammatory response	http://purl.obolibrary.org/obo/GO_0060265		
GO:0060266	biolink:BiologicalProcess	negative regulation of respiratory burst involved in inflammatory response	Any process that decreases the rate, frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases made as a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.		hp.json	negative regulation of respiratory burst involved in acute inflammatory response	http://purl.obolibrary.org/obo/GO_0060266		
GO:0060267	biolink:BiologicalProcess	positive regulation of respiratory burst	Any process that increases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.		hp.json		http://purl.obolibrary.org/obo/GO_0060267		
GO:0060268	biolink:BiologicalProcess	negative regulation of respiratory burst	Any process that decreases the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.		hp.json		http://purl.obolibrary.org/obo/GO_0060268		
GO:0060294	biolink:BiologicalProcess	cilium movement involved in cell motility	Movement of cilia mediated by motor proteins that contributes to the movement of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060294		
GO:0060295	biolink:BiologicalProcess	regulation of cilium movement involved in cell motility	Any process that modulates the rate frequency or extent of cilium movement involved in ciliary motility.		hp.json		http://purl.obolibrary.org/obo/GO_0060295		
GO:0060297	biolink:BiologicalProcess	regulation of sarcomere organization	Any process that modulates the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.		hp.json	regulation of sarcomere organisation	http://purl.obolibrary.org/obo/GO_0060297		
GO:0060298	biolink:BiologicalProcess	positive regulation of sarcomere organization	Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.		hp.json	positive regulation of sarcomere organisation	http://purl.obolibrary.org/obo/GO_0060298		
GO:0060299	biolink:BiologicalProcess	negative regulation of sarcomere organization	Any process that decreases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.		hp.json	negative regulation of sarcomere organisation	http://purl.obolibrary.org/obo/GO_0060299		
GO:0098868	biolink:BiologicalProcess	bone growth	The increase in size or mass of a bone that contributes to the shaping of that bone.		hp.json		http://purl.obolibrary.org/obo/GO_0098868		
GO:0098867	biolink:BiologicalProcess	intramembranous bone growth	The increase in size or mass of an intramembranous bone that contributes to the shaping of the bone.		hp.json		http://purl.obolibrary.org/obo/GO_0098867		
GO:0098871	biolink:CellularComponent	postsynaptic actin cytoskeleton	The actin cytoskeleton that is part of a postsynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0098871		goslim_synapse
GO:0060281	biolink:BiologicalProcess	regulation of oocyte development	Any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060281		
GO:0060282	biolink:BiologicalProcess	positive regulation of oocyte development	Any process that increases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060282		
GO:0060283	biolink:BiologicalProcess	negative regulation of oocyte development	Any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.		hp.json		http://purl.obolibrary.org/obo/GO_0060283		
GO:0060284	biolink:BiologicalProcess	regulation of cell development	Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0060284		
GO:0060285	biolink:BiologicalProcess	cilium-dependent cell motility	Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.		hp.json	microtubule-based flagellar cell motility|ciliary cell motility|cilium cell motility	http://purl.obolibrary.org/obo/GO_0060285		
GO:1900073	biolink:BiologicalProcess	regulation of neuromuscular synaptic transmission	Any process that modulates the frequency, rate or extent of neuromuscular synaptic transmission.		hp.json		http://purl.obolibrary.org/obo/GO_1900073		
GO:1900075	biolink:BiologicalProcess	positive regulation of neuromuscular synaptic transmission	Any process that activates or increases the frequency, rate or extent of neuromuscular synaptic transmission.		hp.json	up regulation of neuromuscular synaptic transmission|upregulation of neuromuscular synaptic transmission|activation of neuromuscular synaptic transmission|up-regulation of neuromuscular synaptic transmission	http://purl.obolibrary.org/obo/GO_1900075		
GO:1900074	biolink:BiologicalProcess	negative regulation of neuromuscular synaptic transmission	Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular synaptic transmission.		hp.json	inhibition of neuromuscular synaptic transmission|down-regulation of neuromuscular synaptic transmission|down regulation of neuromuscular synaptic transmission|downregulation of neuromuscular synaptic transmission	http://purl.obolibrary.org/obo/GO_1900074		
GO:0098876	biolink:BiologicalProcess	vesicle-mediated transport to the plasma membrane	The directed movement of substances to the plasma membrane in transport vesicles that fuse with the plasma membrane by exocytosis.		hp.json		http://purl.obolibrary.org/obo/GO_0098876		
UBERON:0012283	biolink:AnatomicalEntity	femoral fat pad	Encapsulated adipose tissue associated with the femur.		hp.json	femoral fat depot	http://purl.obolibrary.org/obo/UBERON_0012283		
UBERON:0036253	biolink:AnatomicalEntity	orifice of skull		FMA:53133	hp.json	skull orifice|cranial orifice	http://purl.obolibrary.org/obo/UBERON_0036253		
GO:0050820	biolink:BiologicalProcess	positive regulation of coagulation	Any process that activates or increases the frequency, rate or extent of coagulation.		hp.json	upregulation of coagulation|up-regulation of coagulation|positive regulation of clotting|up regulation of coagulation|activation of coagulation|stimulation of coagulation	http://purl.obolibrary.org/obo/GO_0050820		
UBERON:0012282	biolink:AnatomicalEntity	mammary fat pad	Encapsulated adipose tissue associated with the mammary gland.	EMAPA:37901	hp.json		http://purl.obolibrary.org/obo/UBERON_0012282		pheno_slim
UBERON:0012288	biolink:AnatomicalEntity	centroquartal bone	A tarsal bone that is formed from the fusion of the central and 4th tarsal bones.		hp.json	os naviculocuboideum|os centroquartale	http://purl.obolibrary.org/obo/UBERON_0012288		
UBERON:0012287	biolink:AnatomicalEntity	Rathkes pouch epithelium	An epithelial sac that is part of a Rathke's pouch.	EHDAA2:0001473|EMAPA:25036	hp.json		http://purl.obolibrary.org/obo/UBERON_0012287		
UBERON:0012289	biolink:AnatomicalEntity	fused tarsal bones 2 and 3	A tarsal bone that is formed from the fusion of the 2nd and 3rd tarsal bones.		hp.json	fused tarsals 2 and 3|tarsals 2+3|os tarsale II et III|os cuneiforme intermediolaterale	http://purl.obolibrary.org/obo/UBERON_0012289		
CHEBI:74345	biolink:ChemicalSubstance	1-(5-hydroxy-2-oxo-2,3-dihydroimidazol-4-yl)urea	An imidazolidinone that is imidazolin-2-one substituted at positions 4 and 5 by hydroxy and ureido groups respectively.	PMID:20826786	hp.json	allantoin, enol-form|2-oxo-4-hydroxy-5-ureidoimidazoline|1-(5-hydroxy-2-oxo-2,3-dihydro-1H-imidazol-4-yl)urea	http://purl.obolibrary.org/obo/CHEBI_74345		3_STAR
UBERON:0036262	biolink:AnatomicalEntity	uterine ligament	Any of the eight ligaments pertaining to the uterus including the anterior, posterior, lateral, sacro-uterine and round ligaments.	NCIT:C61360	hp.json		http://purl.obolibrary.org/obo/UBERON_0036262		
UBERON:0036264	biolink:AnatomicalEntity	zygomaticotemporal nerve	The zygomaticotemporal nerve or zygomaticotemporal branch (temporal branch) is derived from the maxillary branch of the trigeminal nerve (Cranial nerve V). It runs along the lateral wall of the orbit in a groove in the zygomatic bone, receives a branch of communication from the lacrimal, and passes through zygomaticotemporal foramen in the zygomatic bone to enter the temporal fossa. It ascends between the bone, and substance of the Temporalis muscle, pierces the temporal fascia about 2.5 cm. above the zygomatic arch, and is distributed to the skin of the side of the forehead, and communicates with the facial nerve and with the auriculotemporal branch of the mandibular nerve. As it pierces the temporal fascia, it gives off a slender twig, which runs between the two layers of the fascia to the lateral angle of the orbit.	SCTID:280243001|Wikipedia:Zygomaticotemporal_nerve|FMA:52972	hp.json	ramus zygomaticotemporalis (Nervus zygomaticus)|zygomaticotemporal branch|ramus zygomaticotemporalis nervus zygomatici|zygomaticotemporal|zygomaticotemporal branch|zygomaticotemporal branch of zygomatic nerve|zygomaticotemporal	http://purl.obolibrary.org/obo/UBERON_0036264		
GO:0050832	biolink:BiologicalProcess	defense response to fungus	Reactions triggered in response to the presence of a fungus that act to protect the cell or organism.		hp.json	defence response to fungus|defence response to fungi|defense response to fungi|response to parasitic fungus|response to parasitic fungi|resistance response to pathogenic fungi|defense response to fungus, incompatible interaction|resistance response to pathogenic fungus	http://purl.obolibrary.org/obo/GO_0050832		
UBERON:0012276	biolink:AnatomicalEntity	endometrium glandular epithelium		FMA:86488|MA:0002732|EMAPA:35308	hp.json	glandular part of endometrium|uterine glands set|uterine glands	http://purl.obolibrary.org/obo/UBERON_0012276		human_reference_atlas
UBERON:0012275	biolink:AnatomicalEntity	meso-epithelium	Epithelium that derives from the mesoderm. [Automatically generated definition].	FMA:86452	hp.json	mesoderm-derived epithelium|mesoepithelium	http://purl.obolibrary.org/obo/UBERON_0012275		
UBERON:0036268	biolink:AnatomicalEntity	pelvic vein		SCTID:13152008	hp.json		http://purl.obolibrary.org/obo/UBERON_0036268		
UBERON:0012274	biolink:AnatomicalEntity	columnar epithelium	An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified].	Wikipedia:Columnar_epithelium	hp.json		http://purl.obolibrary.org/obo/UBERON_0012274		
UBERON:0036267	biolink:AnatomicalEntity	vulval vein			hp.json		http://purl.obolibrary.org/obo/UBERON_0036267		
UBERON:0036269	biolink:AnatomicalEntity	penis blood vessel		EMAPA:30807	hp.json	vasculature of penis|penis vasculature	http://purl.obolibrary.org/obo/UBERON_0036269		
GO:0050839	biolink:MolecularActivity	cell adhesion molecule binding	Binding to a cell adhesion molecule.		hp.json	cell adhesion receptor activity|adhesive extracellular matrix constituent|cell adhesion molecule activity|CAM binding	http://purl.obolibrary.org/obo/GO_0050839		
UBERON:0012278	biolink:AnatomicalEntity	gland of nasal mucosa	The nasal glands are the seromucous glands in the respiratory region of the nasal mucous membrane. The three major types of nasal glands are anterior serous glands, seromucous glands, and Bowman glands.	EMAPA:37871|NCIT:C22725|UMLS:C1522269|FMA:321518	hp.json	glandulae nasales|nasal gland|glandula nasalis	http://purl.obolibrary.org/obo/UBERON_0012278		pheno_slim
CHEBI:86327	biolink:ChemicalSubstance	antifungal drug	Any antifungal agent used to prevent or treat fungal infections in humans or animals.	Wikipedia:Antifungal	hp.json	pharmaceutical fungicide|antifungal medication|antifungal medications|pharmaceutical fungicides|antifungal drugs|anti-fungal medications|anti-fungal drug|anti-fungal medication|anti-fungal drugs	http://purl.obolibrary.org/obo/CHEBI_86327		3_STAR
GO:0050840	biolink:MolecularActivity	extracellular matrix binding	Binding to a component of the extracellular matrix.		hp.json	adhesive extracellular matrix constituent|extracellular matrix constituent binding	http://purl.obolibrary.org/obo/GO_0050840		goslim_pir|goslim_chembl
UBERON:0012251	biolink:AnatomicalEntity	ectocervical epithelium	An epithelium that is part of a ectocervix.		hp.json	exocervical epithelium	http://purl.obolibrary.org/obo/UBERON_0012251		
UBERON:0012250	biolink:AnatomicalEntity	cervix glandular epithelium	A glandular epithelium that is part of a uterine cervix.	UMLS:C1707350|NCIT:C54414	hp.json	cervix columnar epithelium	http://purl.obolibrary.org/obo/UBERON_0012250		human_reference_atlas
UBERON:0036286	biolink:AnatomicalEntity	wall of right ventricle	Wall of ventricle which is continuous with the wall of pulmonary trunk.	FMA:9533	hp.json	right ventricular wall	http://purl.obolibrary.org/obo/UBERON_0036286		
UBERON:0036285	biolink:AnatomicalEntity	wall of left ventricle	Wall of ventricle which is continuous with the wall of aorta.	FMA:9556	hp.json	left ventricular wall	http://purl.obolibrary.org/obo/UBERON_0036285		
UBERON:0036288	biolink:AnatomicalEntity	anterior wall of left ventricle		FMA:9560	hp.json		http://purl.obolibrary.org/obo/UBERON_0036288		
UBERON:0012254	biolink:AnatomicalEntity	abdominal aorta artery	An artery that originates from the abdominal aorta.	SCTID:281470000	hp.json	abdominal artery|artery of abdomen	http://purl.obolibrary.org/obo/UBERON_0012254		pheno_slim
UBERON:0012253	biolink:AnatomicalEntity	cervical squamo-columnar junction	Region of cervical epithelium where columnar epithelium of endocervic and the stratified non-keratinising squamous epithelium of the ectocervic meet.	NCIT:C97148	hp.json	squamocolumnar junction of uterine cervix|squamocolumnar junction|squamo-columnar junction of uterine cervix	http://purl.obolibrary.org/obo/UBERON_0012253		
UBERON:0012252	biolink:AnatomicalEntity	endocervical epithelium	The glandular epithelium that lines the endocervix.	NCIT:C96180	hp.json	endocervical glandular epithelium	http://purl.obolibrary.org/obo/UBERON_0012252		human_reference_atlas
UBERON:0036289	biolink:AnatomicalEntity	anterior wall of right ventricle	Region of wall of right ventricle which is continuous with the lateral and septal walls of right ventricle.	FMA:9553	hp.json		http://purl.obolibrary.org/obo/UBERON_0036289		
UBERON:0012249	biolink:AnatomicalEntity	ectocervix	The part of the cervix uteri that protrudes into the vagina and is lined with stratified squamous epithelium.	UMLS:C0227829|CALOHA:TS-1098|NCIT:C12310|BTO:0001850|FMA:86484|FMA:77056	hp.json	uterine ectocervix|portio vaginalis cervicis|ectocervix|portio vaginalis|ectocervix|exocervix|vaginal part of cervix	http://purl.obolibrary.org/obo/UBERON_0012249		human_reference_atlas
PR:P04040	biolink:Protein	catalase (human)	A catalase that is encoded in the genome of human.	UniProtKB:P04040	hp.json	CAT|hCAT	http://purl.obolibrary.org/obo/PR_P04040		
GO:0050863	biolink:BiologicalProcess	regulation of T cell activation	Any process that modulates the frequency, rate or extent of T cell activation.		hp.json	regulation of T-cell activation|regulation of T-lymphocyte activation|regulation of T lymphocyte activation	http://purl.obolibrary.org/obo/GO_0050863		
GO:0050866	biolink:BiologicalProcess	negative regulation of cell activation	Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation.		hp.json	down-regulation of cell activation|down regulation of cell activation|inhibition of cell activation|downregulation of cell activation	http://purl.obolibrary.org/obo/GO_0050866		
GO:0050867	biolink:BiologicalProcess	positive regulation of cell activation	Any process that activates or increases the frequency, rate or extent of activation.		hp.json	activation of cell activation|stimulation of cell activation|upregulation of cell activation|up-regulation of cell activation|up regulation of cell activation	http://purl.obolibrary.org/obo/GO_0050867		
GO:0050864	biolink:BiologicalProcess	regulation of B cell activation	Any process that modulates the frequency, rate or extent of B cell activation.		hp.json	regulation of B lymphocyte activation|regulation of B-cell activation|regulation of B-lymphocyte activation	http://purl.obolibrary.org/obo/GO_0050864		
GO:0050865	biolink:BiologicalProcess	regulation of cell activation	Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.		hp.json		http://purl.obolibrary.org/obo/GO_0050865		
GO:0050868	biolink:BiologicalProcess	negative regulation of T cell activation	Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.		hp.json	down-regulation of T cell activation|down regulation of T cell activation|inhibition of T cell activation|downregulation of T cell activation|negative regulation of T-lymphocyte activation|negative regulation of T lymphocyte activation|negative regulation of T-cell activation	http://purl.obolibrary.org/obo/GO_0050868		
UBERON:0036212	biolink:AnatomicalEntity	intertragic incisure	A surface structure that is the narrowed downward continuation of the conchal space bounded anteriorly by the borders of the tragus, posteriorly by theantitragus, and along its lower lateral margins and inferior boundary by the connection between the first two.	FMA:61175	hp.json	incisura anterior auris|anterior auricular groove|sulcus auriculae anterior|incisura intertragica|intertragic incisure|incisura|intertragal incisure|auricular notch|intertragic incisure|intertragic notch	http://purl.obolibrary.org/obo/UBERON_0036212		
GO:0050869	biolink:BiologicalProcess	negative regulation of B cell activation	Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.		hp.json	negative regulation of B-cell activation|down-regulation of B cell activation|down regulation of B cell activation|downregulation of B cell activation|inhibition of B cell activation|negative regulation of B-lymphocyte activation|negative regulation of B lymphocyte activation	http://purl.obolibrary.org/obo/GO_0050869		
UBERON:0036215	biolink:AnatomicalEntity	anatomical surface region	Material anatomical entity that forms the outermost boundary of an anatomical structure.	ZFA:0005594|AEO:0000154|AAO:0010270	hp.json		http://purl.obolibrary.org/obo/UBERON_0036215		
UBERON:0036214	biolink:AnatomicalEntity	rectosigmoid junction	An anatomical junction that is between the sigmoid colon and rectum.	NCIT:C54188|SCTID:245429006	hp.json	rectosigmoid region	http://purl.obolibrary.org/obo/UBERON_0036214		
UBERON:0036217	biolink:AnatomicalEntity	coelomic fluid	A bodily fluid that is located in the coelom.	BTO:0001708	hp.json		http://purl.obolibrary.org/obo/UBERON_0036217		
CL:0002585	biolink:Cell	retinal blood vessel endothelial cell	A blood vessel endothelial cell that is part of the retina.		hp.json		http://purl.obolibrary.org/obo/CL_0002585		
GO:2001233	biolink:BiologicalProcess	regulation of apoptotic signaling pathway	Any process that modulates the frequency, rate or extent of apoptotic signaling pathway.		hp.json	regulation of apoptotic signalling pathway	http://purl.obolibrary.org/obo/GO_2001233		
GO:2001234	biolink:BiologicalProcess	negative regulation of apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.		hp.json	negative regulation of apoptotic signalling pathway	http://purl.obolibrary.org/obo/GO_2001234		
GO:2001235	biolink:BiologicalProcess	positive regulation of apoptotic signaling pathway	Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.		hp.json	positive regulation of apoptotic signalling pathway	http://purl.obolibrary.org/obo/GO_2001235		
CL:0002589	biolink:Cell	smooth muscle cell of the brachiocephalic vasculature	A smooth muscle cell of the bachiocephalic vasculature.		hp.json		http://purl.obolibrary.org/obo/CL_0002589		
GO:0098802	biolink:CellularComponent	plasma membrane signaling receptor complex	Any protein complex that is part of the plasma membrane and which functions as a signaling receptor.		hp.json		http://purl.obolibrary.org/obo/GO_0098802		gocheck_do_not_manually_annotate
GO:0098803	biolink:CellularComponent	respiratory chain complex	Any protein complex that is part of a respiratory chain.		hp.json		http://purl.obolibrary.org/obo/GO_0098803		
GO:0098800	biolink:CellularComponent	inner mitochondrial membrane protein complex	Any protein complex that is part of the inner mitochondrial membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0098800		
GO:0098801	biolink:BiologicalProcess	regulation of renal system process	Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by the renal system.		hp.json		http://purl.obolibrary.org/obo/GO_0098801		
GO:0050871	biolink:BiologicalProcess	positive regulation of B cell activation	Any process that activates or increases the frequency, rate or extent of B cell activation.		hp.json	positive regulation of B-lymphocyte activation|up-regulation of B cell activation|positive regulation of B lymphocyte activation|positive regulation of B-cell activation|up regulation of B cell activation|activation of B cell activation|stimulation of B cell activation|upregulation of B cell activation	http://purl.obolibrary.org/obo/GO_0050871		
GO:0050877	biolink:BiologicalProcess	nervous system process	A organ system process carried out by any of the organs or tissues of neurological system.		hp.json	neurophysiological process|neurological system process|pan-neural process	http://purl.obolibrary.org/obo/GO_0050877		goslim_pir|goslim_flybase_ribbon|goslim_chembl|goslim_generic|goslim_agr
GO:0050878	biolink:BiologicalProcess	regulation of body fluid levels	Any process that modulates the levels of body fluids.		hp.json		http://purl.obolibrary.org/obo/GO_0050878		goslim_pir
GO:1902623	biolink:BiologicalProcess	negative regulation of neutrophil migration	Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil migration.		hp.json	down regulation of neutrophil migration|inhibition of neutrophil migration|down-regulation of neutrophil migration|downregulation of neutrophil migration	http://purl.obolibrary.org/obo/GO_1902623		
GO:1902624	biolink:BiologicalProcess	positive regulation of neutrophil migration	Any process that activates or increases the frequency, rate or extent of neutrophil migration.		hp.json	upregulation of neutrophil migration|up regulation of neutrophil migration|up-regulation of neutrophil migration|activation of neutrophil migration	http://purl.obolibrary.org/obo/GO_1902624		
UBERON:0036224	biolink:AnatomicalEntity	corticobulbar and corticospinal tracts	The corticobulbar and corticospinal tracts combined.		hp.json	pyramidal tract	http://purl.obolibrary.org/obo/UBERON_0036224		
GO:0050879	biolink:BiologicalProcess	multicellular organismal movement	Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0050879		goslim_pir
GO:1902622	biolink:BiologicalProcess	regulation of neutrophil migration	Any process that modulates the frequency, rate or extent of neutrophil migration.		hp.json		http://purl.obolibrary.org/obo/GO_1902622		
UBERON:0036225	biolink:AnatomicalEntity	respiratory system gland	Any gland that is part os the respiratory system.		hp.json		http://purl.obolibrary.org/obo/UBERON_0036225		
CL:0002596	biolink:Cell	smooth muscle cell of the carotid artery	Smooth muscle cell of the carotid artery.		hp.json		http://purl.obolibrary.org/obo/CL_0002596		
CL:0002599	biolink:Cell	smooth muscle cell of the esophagus	A smooth muscle cell of the esophagus.		hp.json		http://purl.obolibrary.org/obo/CL_0002599		
GO:0035290	biolink:BiologicalProcess	trunk segmentation	Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8.		hp.json		http://purl.obolibrary.org/obo/GO_0035290		
GO:0098813	biolink:BiologicalProcess	nuclear chromosome segregation	The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.		hp.json		http://purl.obolibrary.org/obo/GO_0098813		
CL:0002591	biolink:Cell	smooth muscle cell of the pulmonary artery	A smooth muscle of the pulmonary artery.	BTO:0003336	hp.json		http://purl.obolibrary.org/obo/CL_0002591		
GO:0050870	biolink:BiologicalProcess	positive regulation of T cell activation	Any process that activates or increases the frequency, rate or extent of T cell activation.		hp.json	positive regulation of T-lymphocyte activation|up-regulation of T cell activation|positive regulation of T lymphocyte activation|positive regulation of T-cell activation|up regulation of T cell activation|activation of T cell activation|stimulation of T cell activation|upregulation of T cell activation	http://purl.obolibrary.org/obo/GO_0050870		
CL:0002590	biolink:Cell	smooth muscle cell of the brain vasculature	A vascular associated smooth muscle cell of the brain vasculature.		hp.json		http://purl.obolibrary.org/obo/CL_0002590		
GO:0035295	biolink:BiologicalProcess	tube development	The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.		hp.json		http://purl.obolibrary.org/obo/GO_0035295		
GO:0050884	biolink:BiologicalProcess	neuromuscular process controlling posture	Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts.		hp.json	regulation of posture	http://purl.obolibrary.org/obo/GO_0050884		
GO:0050885	biolink:BiologicalProcess	neuromuscular process controlling balance	Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors.		hp.json	regulation of balance	http://purl.obolibrary.org/obo/GO_0050885		
GO:0050886	biolink:BiologicalProcess	endocrine process	The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.		hp.json	endocrine physiology|endocrine physiological process	http://purl.obolibrary.org/obo/GO_0050886		goslim_generic|goslim_pir
GO:2001251	biolink:BiologicalProcess	negative regulation of chromosome organization	Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization.		hp.json	negative regulation of chromosome organization and biogenesis|negative regulation of chromosome organisation|negative regulation of nuclear genome maintenance|negative regulation of maintenance of genome integrity	http://purl.obolibrary.org/obo/GO_2001251		
GO:2001252	biolink:BiologicalProcess	positive regulation of chromosome organization	Any process that activates or increases the frequency, rate or extent of chromosome organization.		hp.json	positive regulation of nuclear genome maintenance|positive regulation of chromosome organisation|positive regulation of chromosome organization and biogenesis|positive regulation of maintenance of genome integrity	http://purl.obolibrary.org/obo/GO_2001252		
CL:0002563	biolink:Cell	intestinal epithelial cell	An epithelial cell of the intestine.		hp.json		http://purl.obolibrary.org/obo/CL_0002563		
GO:0060214	biolink:BiologicalProcess	endocardium formation	Formation of the endocardium of the heart. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.		hp.json		http://purl.obolibrary.org/obo/GO_0060214		
GO:0060218	biolink:BiologicalProcess	hematopoietic stem cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.		hp.json	haematopoietic stem cell differentiation|haemopoietic stem cell differentiation|hemopoietic stem cell differentiation	http://purl.obolibrary.org/obo/GO_0060218		
GO:0060219	biolink:BiologicalProcess	camera-type eye photoreceptor cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye.		hp.json		http://purl.obolibrary.org/obo/GO_0060219		
GO:0035282	biolink:BiologicalProcess	segmentation	The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.	Wikipedia:Segmentation_(biology)	hp.json		http://purl.obolibrary.org/obo/GO_0035282		
GO:0050881	biolink:BiologicalProcess	musculoskeletal movement	The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system.		hp.json		http://purl.obolibrary.org/obo/GO_0050881		
UBERON:0012291	biolink:AnatomicalEntity	lateral malleolus of fibula	Malleolus is the name for the bony prominence on each side of the ankle.	FMA:35502|EMAPA:37893	hp.json	fibular malleolus|malleolar bone of ankle|malleolar bone|lateral malleolus|external malleolus of fibula|distal extremity of fibula	http://purl.obolibrary.org/obo/UBERON_0012291		
UBERON:0012290	biolink:AnatomicalEntity	fused carpal bones 2 and 3	A carpal bone that is formed from the fusion of the 2nd and 3rd distal carpal bones.		hp.json	carpals 2+3|fused carpals 2 and 3	http://purl.obolibrary.org/obo/UBERON_0012290		
GO:0050896	biolink:BiologicalProcess	response to stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.		hp.json	physiological response to stimulus	http://purl.obolibrary.org/obo/GO_0050896		goslim_mouse|goslim_agr|gocheck_do_not_manually_annotate|prokaryote_subset|goslim_pir|goslim_flybase_ribbon
UBERON:0036242	biolink:AnatomicalEntity	post-embryonic notochord	A notochord that has persisted beyond the embryonic stage.		hp.json		http://purl.obolibrary.org/obo/UBERON_0036242		
UBERON:0012292	biolink:AnatomicalEntity	embryonic cloacal fold	One of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly.	EHDAA2:0004009	hp.json	cloacal fold	http://purl.obolibrary.org/obo/UBERON_0012292		
UBERON:0012299	biolink:AnatomicalEntity	mucosa of urethra	A mucosa that is part of a urethra.	FMA:76904|EMAPA:37912	hp.json	tunica mucosa urethrae|urethral mucosa|mucous membrane of urethra	http://purl.obolibrary.org/obo/UBERON_0012299		
UBERON:0036244	biolink:AnatomicalEntity	secretion of serous membrane	A transudate found in the serous sac.	FMA:20932	hp.json	serous fluid|serous sac fluid	http://purl.obolibrary.org/obo/UBERON_0036244		
UBERON:0036243	biolink:AnatomicalEntity	vaginal fluid	Fluid that lines the vaginal walls that consists of multiple secretions that collect in the vagina from different glands.		hp.json	vaginal discharge|vaginal secretion	http://purl.obolibrary.org/obo/UBERON_0036243		
UBERON:0036246	biolink:AnatomicalEntity	incudostapedial joint	The small synovial joint connecting the inclus and the stapes, located between the lenticular process on the long crus of the incus and the head of the stapes.	FMA:60065	hp.json	articulatio incudostapedialis|incudostapedial articulation	http://purl.obolibrary.org/obo/UBERON_0036246		
UBERON:0036245	biolink:AnatomicalEntity	parenchyma of mammary gland	Parenchymal tissue that consists of the alveoli, grape-like clusters where milk is stored, and branching ducts, which are tubular canals carrying gladular secretions.		hp.json	mammary gland parenchyma|parenchyma of lactiferous gland|lactiferous gland parenchyma	http://purl.obolibrary.org/obo/UBERON_0036245		
UBERON:0036248	biolink:AnatomicalEntity	joint of auditory ossicle	Any synovial joint that connects auditory ossicles.	FMA:60063	hp.json	auditory ossicle joint|joint of auditory ossicles|auditory ossicles joint	http://purl.obolibrary.org/obo/UBERON_0036248		
UBERON:0036247	biolink:AnatomicalEntity	incudomallear joint	The saddle-shaped synovial joint connecting the incus and the malleus.	FMA:60064	hp.json	incudomalleolar joint|articulatio incudomallearis|incudomallear articulation	http://purl.obolibrary.org/obo/UBERON_0036247		
CL:0002573	biolink:Cell	Schwann cell	A glial cell that ensheathes axons of neuron in the peripheral nervous system and are necessary for their maintainance and function.	CALOHA:TS-0898|BTO:0001220	hp.json		http://purl.obolibrary.org/obo/CL_0002573		
CL:0002577	biolink:Cell	placental epithelial cell	An epithelial cell of the placenta.		hp.json		http://purl.obolibrary.org/obo/CL_0002577		
GO:0035270	biolink:BiologicalProcess	endocrine system development	Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.		hp.json		http://purl.obolibrary.org/obo/GO_0035270		
GO:0035272	biolink:BiologicalProcess	exocrine system development	Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.		hp.json		http://purl.obolibrary.org/obo/GO_0035272		
GO:0050891	biolink:NamedThing	multicellular organismal water homeostasis			hp.json		http://purl.obolibrary.org/obo/GO_0050891		
GO:0050892	biolink:BiologicalProcess	intestinal absorption	Any process in which nutrients are taken up from the contents of the intestine.		hp.json		http://purl.obolibrary.org/obo/GO_0050892		
GO:0050890	biolink:BiologicalProcess	cognition	The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.	Wikipedia:Cognition	hp.json		http://purl.obolibrary.org/obo/GO_0050890		goslim_drosophila
CL:0002570	biolink:Cell	mesenchymal stem cell of adipose tissue	A mesenchymal stem cell of adipose tissue.		hp.json	mesenchymal stem cell of adipose	http://purl.obolibrary.org/obo/CL_0002570		
CHEBI:49302	biolink:ChemicalSubstance	2-hydroxy monocarboxylic acid			hp.json	2-hydroxy acid|2-hydroxy monocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_49302		3_STAR
HP:0020127	biolink:PhenotypicFeature	Periarticular soft-tissue mass	A lump detected in the region that surrounds a joiny. In this context, mass is a general term for a lump or growth that may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction.		hp.json		http://purl.obolibrary.org/obo/HP_0020127		
HP:0020126	biolink:PhenotypicFeature	Prostate mass	A lump detected in the prostate. In this context, mass is a general term for a lump or growth that may be caused by the abnormal growth of cells, a cyst, hormonal changes, or an immune reaction.		hp.json		http://purl.obolibrary.org/obo/HP_0020126		
HP:0020129	biolink:PhenotypicFeature	Abnormal urine protein level	Any deviation of the concentration of one or more proteins in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020129		
CHEBI:76924	biolink:ChemicalSubstance	plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.		hp.json	plant secondary metabolites|plant metabolites	http://purl.obolibrary.org/obo/CHEBI_76924		3_STAR
HP:0020128	biolink:PhenotypicFeature	Aplasia of the olfactory tract	Aplasia (congenital absence) of the olfactory tract, which causes anosmia, a complete loss of the sense of smell.		hp.json		http://purl.obolibrary.org/obo/HP_0020128		
UBERON:0012321	biolink:AnatomicalEntity	deep cervical artery	The deep cervical artery (Profunda cervicalis) is an artery of the neck.	Wikipedia:Deep_cervical_artery|FMA:10659|SCTID:244223002	hp.json	profunda cervicalis|profunda cervicalis	http://purl.obolibrary.org/obo/UBERON_0012321		human_reference_atlas
HP:0032112	biolink:PhenotypicFeature	Abnormal Pelli Robson contrast sensitivity chart test	An abnormality in perception of contrast as measured by the Pelli-Robson contrast sensitivity chart, which is a large wall-mounted chart, with letters of a fixed size (comprising spatial frequencies appropriate for estimating peak contrast sensitivity) that decrease in contrast.		hp.json		http://purl.obolibrary.org/obo/HP_0032112		
HP:0032113	biolink:PhenotypicFeature	Semidominant inheritance	A mode of inheritance that is observed for traits related to a gene encoded on chromosomes in which a trait can manifest in a monoallelic (e.g. heterozygotes) and biallelic (e.g. homozygotes, compound heterozygotes) state, with similar or differing phenotype severity present dependent on the number of alleles affected.		hp.json	Semidominant mode of inheritance	http://purl.obolibrary.org/obo/HP_0032113		
UBERON:0012320	biolink:AnatomicalEntity	cervical artery	An artery of the neck.	EMAPA:37075|NCIT:C52850|UMLS:C1707349	hp.json		http://purl.obolibrary.org/obo/UBERON_0012320		
HP:0032114	biolink:PhenotypicFeature	Saccadic intrusion	An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by a delayed corrective saccade.		hp.json		http://purl.obolibrary.org/obo/HP_0032114		
CHEBI:76928	biolink:ChemicalSubstance	2,3-saturated fatty acid(1-)	A fatty acid anion obtained by deprotonation of the carboxy group of any 2,3-saturated fatty acid.		hp.json	2,3-saturated fatty acid	http://purl.obolibrary.org/obo/CHEBI_76928		3_STAR
CHEBI:76929	biolink:ChemicalSubstance	2,3-saturated fatty acid	Any fatty acid in which the first two carbons of the chain attached to the carboxy group are saturated and unbranched.		hp.json		http://purl.obolibrary.org/obo/CHEBI_76929		3_STAR
UBERON:0012324	biolink:AnatomicalEntity	transverse cervical artery	The transverse cervical artery (transverse artery of neck, transversa colli artery) is a branch of the thyrocervical trunk, running at a higher level than the suprascapular artery.	MA:0001936|FMA:10664	hp.json	cervical artery|transversalis colli artery|cervical artery|transverse cervical|descending branch of the transverse cervical|transverse cervical vessels|transversalis artery colli|cervical transverse artery	http://purl.obolibrary.org/obo/UBERON_0012324		human_reference_atlas
HP:0032110	biolink:PhenotypicFeature	Severely reduced contrast sensitivity	A severe reduction in the ability to perceive visual contrast characterized by 1.00 log unit or more contrast sensitivity loss.		hp.json		http://purl.obolibrary.org/obo/HP_0032110		
HP:0032111	biolink:PhenotypicFeature	Abnormal Vistech contrast sensitivity test	An abnormality in perception of contrast as measured by the Vistech wall chart sine wave grating test.		hp.json		http://purl.obolibrary.org/obo/HP_0032111		
UBERON:0012318	biolink:AnatomicalEntity	anterior ethmoidal artery	The anterior ethmoidal artery, also anterior ethmoid artery is an artery of the head. Once branching from the ophthalmic artery, it accompanies the nasociliary nerve through the anterior ethmoidal canal to supply the anterior and middle ethmoidal cells, frontal sinus, and anterosuperior aspect of the lateral nasal wall[WP].	FMA:49986	hp.json	anterior meningeal artery|anterior meningeal arteries|arteria ethmoidalis anterior|anterior ethmoid artery|a. ethmoidalis anterior	http://purl.obolibrary.org/obo/UBERON_0012318		human_reference_atlas
UBERON:0012317	biolink:AnatomicalEntity	vagina orifice	The median slit located inferior and posterior to the external urethral orifice in the female; the exit for menstrual flow and birth and the entrance for the penis during sexual intercourse; the size and appearance of the vaginal orifice varies inversely with that of the hymen (G. membrane), a thin fold of mucous membrane that surrounds the vaginal orifice.	EMAPA:37983|FMA:19984	hp.json	orifice of vagina|introitus of vagina|vagina opening|opening of vagina|introitus|introitus|vaginal orifice|vaginal introitus|ostium vaginae	http://purl.obolibrary.org/obo/UBERON_0012317		pheno_slim
HP:0032116	biolink:PhenotypicFeature	Macrosquare-wave jerks	Horizontal 10-40 degree excursions from fixation and back again.		hp.json		http://purl.obolibrary.org/obo/HP_0032116		
HP:0007149	biolink:PhenotypicFeature	Distal upper limb amyotrophy	Muscular atrophy of distal arm muscles.	UMLS:C4021581	hp.json	Distal upper limb muscle atrophy	http://purl.obolibrary.org/obo/HP_0007149		
HP:0032117	biolink:PhenotypicFeature	obsolete Macrosaccadic oscillation			hp.json		http://purl.obolibrary.org/obo/HP_0032117		
HP:0032118	biolink:PhenotypicFeature	Retinitis	Inflammation of the retina of the eye.		hp.json		http://purl.obolibrary.org/obo/HP_0032118		
UBERON:0012319	biolink:AnatomicalEntity	posterior ethmoidal artery	The posterior ethmoidal artery is an artery of the head. It is smaller than the anterior ethmoidal artery, branches off from the ophthalmic artery when it reaches the medial wall of the orbit.	FMA:49989	hp.json	a. ethmoidalis posterior|posterior ethmoidal vessel|arteria ethmoidalis posterior	http://purl.obolibrary.org/obo/UBERON_0012319		human_reference_atlas
HP:0032119	biolink:PhenotypicFeature	Narrow angle glaucoma	A type of glaucomatous optic neuropathy occuring in the presence of a narrow anterior chamber angle.		hp.json		http://purl.obolibrary.org/obo/HP_0032119		
HP:0020123	biolink:PhenotypicFeature	Tympanosclerosis	A stiffening of the tympanic membrane due to calcification, typically presents as white plaque-like lesions, involving discrete regions of the tympanic membrane and/or middle ear.		hp.json	Tympanic calcification	http://purl.obolibrary.org/obo/HP_0020123		
UBERON:0000344	biolink:AnatomicalEntity	mucosa	A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP].	EV:0100382|AEO:0000199|galen:Mucosa|EHDAA2_RETIRED:0003234|OpenCyc:Mx4rvmKNOpwpEbGdrcN5Y29ycA|Wikipedia:Mucous_membrane|SCTID:361693009|GAID:297|CALOHA:TS-2031|BTO:0000886|FMA:85358|UMLS:C0026724|MESH:D009092|FMA:85355|NCIT:C13166	hp.json	mucosal region|region of mucosa|mucosa of organ|tunica mucosa|tunica mucosa|organ mucosa|mucous membrane|tunica mucosa|mucosa of organ part	http://purl.obolibrary.org/obo/UBERON_0000344		pheno_slim
HP:0020122	biolink:PhenotypicFeature	Bite cells	Red blood cells that appear to have parts of them bitten away.		hp.json	Blister cells|Degmacytes	http://purl.obolibrary.org/obo/HP_0020122		
HP:0007146	biolink:PhenotypicFeature	Bilateral basal ganglia lesions		UMLS:C4024932	hp.json		http://purl.obolibrary.org/obo/HP_0007146		
HP:0020125	biolink:PhenotypicFeature	Spontaneous conjunctival filtering bleb	Avascular cystic elevations of the superior conjunctiva not related to ocular surgery or trauma.		hp.json	Spontaneous filtering bleb|Conjunctival avascular cysts (filtering blebs)	http://purl.obolibrary.org/obo/HP_0020125		
UBERON:0000345	biolink:AnatomicalEntity	myelin	A dielectric (electrically insulating) material consisting of protein and fat that forms a layer, the myelin sheath, usually around only the axon of a neuron. Myelin is about 40 % water; the dry mass of myelin is about 70 - 85 % lipids and about 15 - 30 % proteins. Some of the proteins that make up myelin are myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and proteolipid protein (PLP). The primary lipid of myelin is a glycolipid called galactocerebroside (GalC). The intertwining hydrocarbon chains of sphingomyelin serve to strengthen the myelin sheath.	FMA:62977|ncithesaurus:Myelin|BTO:0000894	hp.json		http://purl.obolibrary.org/obo/UBERON_0000345		pheno_slim
HP:0007141	biolink:PhenotypicFeature	Sensorimotor neuropathy		UMLS:C1112256	hp.json	Sensorimotor peripheral neuropathy|Mixed polyneuropathy|Nerve damage causing decreased feeling and movement	http://purl.obolibrary.org/obo/HP_0007141		
HP:0020121	biolink:PhenotypicFeature	Conception by assisted reproductive technology	A history of conception by an assisted reproductive technology such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and cryopreservation.		hp.json		http://purl.obolibrary.org/obo/HP_0020121		
HP:0020120	biolink:PhenotypicFeature	Retinal nerve fiber edema	Swelling (edema) of the retinal nerve fibers.		hp.json	Retinal nerve fibre oedema	http://purl.obolibrary.org/obo/HP_0020120		
HP:0020119	biolink:PhenotypicFeature	Abnormal retinal nerve fiber layer morphology	A structural abnormality of the retinal nerve fiber layer		hp.json	Abnormal retinal nerve fibre layer morphology	http://purl.obolibrary.org/obo/HP_0020119		
CHEBI:25345	biolink:ChemicalSubstance	methyltetrahydrofolate	A group of heterocyclic compounds based on the N-methylated 5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.		hp.json	methyltetrahydrofolates	http://purl.obolibrary.org/obo/CHEBI_25345		3_STAR
CHEBI:76932	biolink:ChemicalSubstance	pathway inhibitor	An enzyme inhibitor that interferes with one or more steps in a metabolic pathway.		hp.json	pathway inhibitors|metabolic pathway inhibitors|metabolic pathway inhibitor	http://purl.obolibrary.org/obo/CHEBI_76932		3_STAR
HP:0007162	biolink:PhenotypicFeature	Diffuse demyelination of the cerebral white matter	A diffuse loss of myelin from nerve fibers in the central nervous system.	UMLS:C4024930	hp.json		http://purl.obolibrary.org/obo/HP_0007162		
UBERON:0002988	biolink:AnatomicalEntity	first dorsal interosseous of manus		FMA:37424	hp.json	abductor indicis|first dorsal interosseous muscle of hand|first dorsal interosseous of hand	http://purl.obolibrary.org/obo/UBERON_0002988		pheno_slim
UBERON:0000325	biolink:AnatomicalEntity	gastric gland	The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin.	EMAPA:27181|FMA:14919|BTO:0000503	hp.json		http://purl.obolibrary.org/obo/UBERON_0000325		pheno_slim|organ_slim
UBERON:0000326	biolink:AnatomicalEntity	pancreatic juice	Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.	GAID:1166|CALOHA:TS-2235|BTO:0000504|MESH:D010189|FMA:62973	hp.json	pancreatic secretion|succus pancreaticus|pancreatic fluid	http://purl.obolibrary.org/obo/UBERON_0000326		
HP:0020118	biolink:PhenotypicFeature	Radial artery aplasia	Congenital absence of the radial artery.		hp.json		http://purl.obolibrary.org/obo/HP_0020118		
HP:0020117	biolink:PhenotypicFeature	Hypoplastic dermoepidermal hemidesmosomes	Underdeveloped hemidesmosomes at the dermoepidermal junction. Hemidesmosomes are the specialized junctional complexes, that contribute to the attachment of epithelial cells to the underlying basement membrane in stratified and other complex epithelia, such as the skin.		hp.json		http://purl.obolibrary.org/obo/HP_0020117		
UBERON:0000328	biolink:AnatomicalEntity	gut wall	The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity).	FMA:45653|BTO:0000547	hp.json	wall of digestive tract|wall of gut|digestive tract wall|wall of alimentary tract	http://purl.obolibrary.org/obo/UBERON_0000328		
HP:0010797	biolink:PhenotypicFeature	Hemangioblastoma	A hemangioblastoma is a benign vascular neoplasm that arises almost exclusively in the central nervous system. Hemangioblastomas consist of a tightly packed cluster of small blood vessels forming a mass of up to 1 or 2 cm in diameter.	SNOMEDCT_US:81201000|MSH:D018325|UMLS:C0206734|NCIT:C3801	hp.json	Haemangioblastoma	http://purl.obolibrary.org/obo/HP_0010797		
HP:0032123	biolink:PhenotypicFeature	Ultra-low vision	Best corrected visual acuity worse than 1.90 logMAR (roughly 20/1590).		hp.json		http://purl.obolibrary.org/obo/HP_0032123		
HP:0032124	biolink:PhenotypicFeature	Abnormal proportion of unswitched memory B cells	A deviation of the normal proportion of unswitched memory B cells in circulation relative to the total number of B cells.		hp.json	Abnormal proportion of non-class-switched memory B cells	http://purl.obolibrary.org/obo/HP_0032124		
HP:0010796	biolink:PhenotypicFeature	Brainstem glioma	A glioma affecting the brainstem.	SNOMEDCT_US:444545003|UMLS:C0677865	hp.json		http://purl.obolibrary.org/obo/HP_0010796		
HP:0010795	biolink:PhenotypicFeature	Cerebellar glioma	A glioma affecting the cerebellum.	UMLS:C4023700	hp.json		http://purl.obolibrary.org/obo/HP_0010795		
HP:0032125	biolink:PhenotypicFeature	Increased proportion of unswitched memory B cells	An increase above the normal proportion of non-class-switched memory B cells relative to the total number of B cells.		hp.json	Increased proportion of non-class-switched memory B cells|Elevated proportion of unswitched memory B cells	http://purl.obolibrary.org/obo/HP_0032125		
UBERON:0036301	biolink:AnatomicalEntity	vasculature of spleen		FMA:225251	hp.json		http://purl.obolibrary.org/obo/UBERON_0036301		
HP:0032126	biolink:PhenotypicFeature	Decreased proportion of unswitched memory B cells	A reduction below the normal proportion of non-class-switched memory B cells relative to the total number of B cells.		hp.json	Reduced proportion of unswitched memory B cells|Decreased proportion of non-class-switched memory B cells	http://purl.obolibrary.org/obo/HP_0032126		
HP:0010794	biolink:PhenotypicFeature	Impaired visuospatial constructive cognition	Reduced ability affecting mainly visuospatial cognition which may be tested using pattern construction (for example by Differential Ability Scales, which test a person's strengths and weaknesses across a range of intellectual abilities).	UMLS:C4023701	hp.json		http://purl.obolibrary.org/obo/HP_0010794		
HP:0010793	biolink:PhenotypicFeature	Bifid nail	A digit with two nails, with at least some soft tissue between them.	SNOMEDCT_US:110992006|UMLS:C0544857	hp.json	duplicated nail|Notched nail	http://purl.obolibrary.org/obo/HP_0010793		hposlim_core
UBERON:0012314	biolink:AnatomicalEntity	embryonic facial prominence	One of five swellings formed during the development of the face.	SCTID:89066004|FMA:293103	hp.json	primordium of face|facial primordium|embryonic facial process	http://purl.obolibrary.org/obo/UBERON_0012314		
UBERON:0036303	biolink:AnatomicalEntity	vasculature of central nervous system		FMA:259905	hp.json		http://purl.obolibrary.org/obo/UBERON_0036303		
UBERON:0012313	biolink:AnatomicalEntity	1st arch maxillary ectoderm		EMAPA:16389|EHDAA2:0000039	hp.json	ectoderm of maxillary component	http://purl.obolibrary.org/obo/UBERON_0012313		
UBERON:0036302	biolink:AnatomicalEntity	vasculature of central nervous system plus retina			hp.json		http://purl.obolibrary.org/obo/UBERON_0036302		
HP:0032120	biolink:PhenotypicFeature	Abnormal peripheral nervous system physiology	Any functional abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord.		hp.json		http://purl.obolibrary.org/obo/HP_0032120		
UBERON:0012312	biolink:AnatomicalEntity	maxillary process ectoderm		EMAPA:17637|FMA:312685|EHDAA2:0004599	hp.json		http://purl.obolibrary.org/obo/UBERON_0012312		
HP:0032121	biolink:PhenotypicFeature	Froment sign	An abnormal result of a physical examination of the the hand that tests for palsy of the ulnar nerve. This nerve innervates the adductor pollicis and interossei muscles and thereby enables adduction of the thumb and extension of the interphalangeal joint. An abnormal result consists in reduced functionality and muscular weakness in the pinch grip between the thumb and index finger of the affected hand as the patient attempts to pinch a piece of paper that the examiner tries to pull away. The flexor pollicis longus muscle tries to compensate for the weakness by flexing the tip of the thumb at the interphalangeal joint.		hp.json	Froment thumb sign	http://purl.obolibrary.org/obo/HP_0032121		
HP:0010791	biolink:PhenotypicFeature	Hyperplasia of the Leydig cells	Hypertrophy or overdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone.	SNOMEDCT_US:76085008|UMLS:C0023600	hp.json		http://purl.obolibrary.org/obo/HP_0010791		
HP:0010790	biolink:PhenotypicFeature	Hyoplasia of the Leydig cells	Underdevelopment of the interstitial (Leydig) cells of the testis. These cells produce testosterone.	UMLS:C4023702	hp.json		http://purl.obolibrary.org/obo/HP_0010790		
HP:0032122	biolink:PhenotypicFeature	Very low visual acuity	A reduction in visual acuity with best corrected visual acuity between 1.40 (20/500) and 1.89 logMAR (up to roughly 20/1590).		hp.json		http://purl.obolibrary.org/obo/HP_0032122		
UBERON:0036304	biolink:AnatomicalEntity	anatomical border	An anatomical structure that is located along the line dividing two regions of an anatomical structure.		hp.json		http://purl.obolibrary.org/obo/UBERON_0036304		
CHEBI:15999	biolink:ChemicalSubstance	4-hydroxyphenylpyruvic acid	A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.	CAS:156-39-8|HMDB:HMDB0000707|CAS:156-39-8|Wikipedia:4-Hydroxyphenylpyruvic_acid|Beilstein:2691632|Reaxys:2691632|CAS:156-39-8|PDBeChem:ENO|KNApSAcK:C00007512|KEGG:C01179|PMID:11073718|DrugBank:DB07718|PMID:9106023|MetaCyc:P-HYDROXY-PHENYLPYRUVATE	hp.json	3-(4-hydroxyphenyl)-2-oxopropanoic acid|(4-hydroxyphenyl)pyruvic acid|3-(4-HYDROXY-PHENYL)PYRUVIC ACID|(p-hydroxyphenyl)pyruvic acid|4-hydroxyphenylpyruvic acid|3-(p-hydroxyphenyl)-2-oxopropanoic acid|p-Hydroxyphenylpyruvic acid|4-hydroxy alpha-oxobenzenepropanoic acid|3-(4-hydroxyphenyl)pyruvic acid	http://purl.obolibrary.org/obo/CHEBI_15999		3_STAR
HP:0032127	biolink:PhenotypicFeature	Abnormal plasmablast proportion	A deviation from the normal proportion of plasmablasts in circulation relative to total number of B cells. Plasmablasts are antibody-secreting cells that originate after infection or vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0032127		
HP:0032128	biolink:PhenotypicFeature	Increased proportion of plasmablasts	An elevation above the normal proportion of plasmablasts in circulation relative to total number of B cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032128		
HP:0010799	biolink:PhenotypicFeature	Pinealoma	A neoplasm of the pineal gland.	MSH:D010871|NCIT:C3328|SNOMEDCT_US:359619007|SNOMEDCT_US:47598005|SNOMEDCT_US:127026004|UMLS:C0031941	hp.json		http://purl.obolibrary.org/obo/HP_0010799		
HP:0032129	biolink:PhenotypicFeature	Decreased proportion of plasmablasts	A reduction below the normal proportion of plasmablasts in circulation relative to total number of B cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032129		
HP:0010798	biolink:PhenotypicFeature	Lip freckle	Increased focal pigmentation of the vermilion of the lips.	UMLS:C0406814|SNOMEDCT_US:239136007	hp.json	Labial lentigo|Ephelis of lip|Lip lentigo|Lip freckle	http://purl.obolibrary.org/obo/HP_0010798		hposlim_core
HP:0020112	biolink:PhenotypicFeature	Increased proportion of CD4+CD25+ regulatory T cells	An abnormally increased proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells.		hp.json	Elevated proportion of CD4+CD25+ regulatory T cells|Increased proportion of CD4+CD25+ Treg cells	http://purl.obolibrary.org/obo/HP_0020112		
UBERON:0000332	biolink:AnatomicalEntity	yellow bone marrow	Bone marrow in which the fat cells predominate in the meshes of the reticular network.	FMA:74596|SCTID:328639002|SCTID:5023006|BTO:0000635	hp.json	fat marrow|yellow marrow|medulla ossium flava	http://purl.obolibrary.org/obo/UBERON_0000332		
HP:0007156	biolink:PhenotypicFeature	Asymmetric limb muscle stiffness	Stiffness of the limbs (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) occurring in an asymmetric pattern.	UMLS:C4024931	hp.json		http://purl.obolibrary.org/obo/HP_0007156		
UBERON:0000333	biolink:AnatomicalEntity	intestinal gland	A gland that is part of the intestinal mucosa. Examples include the intestinal crypts, duodenal gland[cjm].	BTO:0000640|FMA:15052|SCTID:266297002	hp.json	gland of mucosa of organ of intestine|bowel mucous membrane gland|gland of organ mucosa of intestine|gland of intestine mucosa|gland of intestine mucosa of organ|mucosa of organ of bowel gland|gland of mucosa of intestine|bowel mucosa gland|gland of intestine organ mucosa|glandulae intestinales|gland of mucous membrane of bowel|bowel organ mucosa gland|mucous membrane of intestine gland|organ mucosa of intestine gland|intestine mucosa of organ gland|glandula intestinalis|gland of intestinal mucosa|mucosa of intestine gland|gland of intestine mucous membrane|intestinal mucosa gland|gland of mucosa of organ of bowel|mucosa of organ of intestine gland|gland of bowel mucosa|intestine mucous membrane gland|gland of bowel mucosa of organ|gland of organ mucosa of bowel|gland of mucosa of bowel|gland of bowel organ mucosa|intestine mucosa gland|intestine organ mucosa gland|gland of mucous membrane of intestine|mucous membrane of bowel gland|bowel mucosa of organ gland|organ mucosa of bowel gland|mucosa of bowel gland|gland of bowel mucous membrane	http://purl.obolibrary.org/obo/UBERON_0000333		organ_slim
HP:0020111	biolink:PhenotypicFeature	Abnormal CD4+CD25+ regulatory T cell proportion	A deviation from the normal proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells.		hp.json	Abnormal CD4+CD25+ Treg cell proportion	http://purl.obolibrary.org/obo/HP_0020111		
HP:0020114	biolink:PhenotypicFeature	Persistent human papillomavirus infection	Human papillomaviruses (HPVs) are small oncogenic viruses. HPV has been shown to cause a variety of lesions and malignancies, which predominantly affect the anogenital region. Low-risk, non-oncogenic HPV types are associated with anogenital warts and recurrent respiratory papillomatosis while high-risk, oncogenic types are associated with cervical, penile, anal, vaginal, vulvar, and oropharyngeal cancers. Infection with anogenital HPV is usually asymptomatic and resolves spontaneously without consequences in the immunocompetent host. When disease does occur, the most common manifestation is genital warts, which may be small papules, or flat, smooth or pedunculated lesions. This resolution of HPV lesions is not generally seen in the immunosuppressed, resulting in severe, persistent and extensive manifestations of HPV disease.		hp.json		http://purl.obolibrary.org/obo/HP_0020114		
HP:0007158	biolink:PhenotypicFeature	Progressive extrapyramidal muscular rigidity	A progressive degree of muscular rigidity (continuous contraction of muscles with constant resistance to passive movement).	UMLS:C4021580	hp.json	Progressive extrapyramidal rigidity	http://purl.obolibrary.org/obo/HP_0007158		
HP:0020113	biolink:PhenotypicFeature	Decreased proportion of CD4+CD25+ regulatory T cells	An abnormally decreased proportion of CD4-positive, CD25-positive, alpha-beta regulatory T cells in circulation, relative to another population of cells.		hp.json	Decreased proportion of CD4+CD25+ Treg cells|Reduced proportion of CD4+CD25+ regulatory T cells	http://purl.obolibrary.org/obo/HP_0020113		
HP:0007159	biolink:PhenotypicFeature	Fluctuations in consciousness		UMLS:C1851959	hp.json		http://purl.obolibrary.org/obo/HP_0007159		
HP:0007153	biolink:PhenotypicFeature	Progressive extrapyramidal movement disorder		UMLS:C2748610	hp.json		http://purl.obolibrary.org/obo/HP_0007153		
HP:0020110	biolink:PhenotypicFeature	Bone fracture	A partial or complete breakage of the continuity of a bone.		hp.json		http://purl.obolibrary.org/obo/HP_0020110		
UBERON:0000331	biolink:AnatomicalEntity	ileal mucosa	A mucosa that is part of a ileum [Automatically generated definition].	EMAPA:35424|BTO:0000619|MA:0003216|CALOHA:TS-0470|FMA:14956	hp.json	ileum mucosa|ileum mucosa of organ|organ mucosa of ileum|mucous membrane of ileum|mucosa of ileum|ileum mucous membrane|mucosa of organ of ileum|ileal mucous membrane|ileum mucosa|ileum organ mucosa	http://purl.obolibrary.org/obo/UBERON_0000331		human_reference_atlas
HP:0020108	biolink:PhenotypicFeature	Unusual parasitic infection	An unusual parasitic infection that is regarded as a sign of a pathological susceptibility to infection by a parasite.		hp.json		http://purl.obolibrary.org/obo/HP_0020108		
HP:0009791	biolink:PhenotypicFeature	Bifid sacrum	Presence of a bifid sacral bone.	UMLS:C4024204	hp.json		http://purl.obolibrary.org/obo/HP_0009791		
HP:0009790	biolink:PhenotypicFeature	Hemisacrum	A hemisacral defect involving the sacral vertebrae S2 to S5. In hemisacrum, the first sacral vertebra is intact and there is agenesis involving only S2-S5.	UMLS:C2677632	hp.json		http://purl.obolibrary.org/obo/HP_0009790		
HP:0020105	biolink:PhenotypicFeature	Severe toxoplasmosis	Toxoplasmosis is a widespread parasitic infection that is frequently asymptomatic in immunocompetent patients. However, this obligate intracellular protozoan parasite can evade the immune system and persist for the life of its host in cyst form, predominantly in the brain, retina, and muscles. Reactivation of latent cysts may occur when the immune system fails to maintain cytokine pressure, which mainly relies on gamma interferon (IFN-gamma). Toxoplasmosis is a life-threatening infection in immunocompromised patients (ICPs).		hp.json		http://purl.obolibrary.org/obo/HP_0020105		
UBERON:0000315	biolink:AnatomicalEntity	subarachnoid space	The space between the arachnoid and pia mater.	MESH:D013346|EMAPA:32666|GAID:689|BTO:0000230|FMA:83716	hp.json	spatium subarachnoideum|subarachnoid space of CNS|spatium leptomeningeum|subarachnoid space of central nervous system|spatium subarachnoideum|cavum subarachnoideale|cavitas subarachnoidea|subarachnoid cavity|subarachnoid space of neuraxis	http://purl.obolibrary.org/obo/UBERON_0000315		pheno_slim
HP:0020104	biolink:PhenotypicFeature	Unusual protozoan infection	An unusual protozoan infection that is regarded as a sign of a pathological susceptibility to infection by a protozoal agent.		hp.json		http://purl.obolibrary.org/obo/HP_0020104		
CHEBI:76946	biolink:ChemicalSubstance	fungal metabolite	Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.		hp.json	fungal metabolites	http://purl.obolibrary.org/obo/CHEBI_76946		3_STAR
UBERON:0000316	biolink:AnatomicalEntity	cervical mucus	A substance produced by the cervix and endocervical glands[BTO]. Thick acidic mucus that blocks the cervical os after mestruation[WP]. This 'infertile' mucus blocks spermatozoa from entering the uterus.	MESH:D002582|BTO:0000242|FMA:83689	hp.json	cervix mucus	http://purl.obolibrary.org/obo/UBERON_0000316		
HP:0020107	biolink:PhenotypicFeature	Unusual helminthic infection	An unusual helminthic infection that is regarded as a sign of a pathological susceptibility to infection by a worm (helminth).		hp.json		http://purl.obolibrary.org/obo/HP_0020107		
UBERON:0000317	biolink:AnatomicalEntity	colonic mucosa	Mucosa that is part of a colon. The mucosa of the colon is lined by a simple columnar epithelium with a thin brush border and numerous goblet cells.	SCTID:362157008|FMA:85388|EFO:0003038|MA:0003194|FMA:14984|BTO:0000271|CALOHA:TS-0164|EMAPA:27375	hp.json	colonic mucous membrane|colonic mucosa|large bowel mucosa|mucosa of colon|colon mucosa|mucosa of large bowel|colon mucous membrane	http://purl.obolibrary.org/obo/UBERON_0000317		human_reference_atlas|efo_slim
HP:0020106	biolink:PhenotypicFeature	Severe giardiasis	An unusually severe infection due to Giardia lamblia, also called Giardia duodenalis or Giardia intestinalis, which is a protozoan parasite of the small intestine that causes extensive morbidity worldwide.		hp.json		http://purl.obolibrary.org/obo/HP_0020106		
HP:0010786	biolink:PhenotypicFeature	Urinary tract neoplasm	The presence of a neoplasm of the urinary system.	SNOMEDCT_US:126879004|UMLS:C0042076|MSH:D014571|SNOMEDCT_US:254913005|NCIT:C3262	hp.json	Urinary tract neoplasia	http://purl.obolibrary.org/obo/HP_0010786		
HP:0032134	biolink:PhenotypicFeature	Chronic decreased circulating total IgG	A lasting reduction beneath the normal level of total immunoglobulin G (IgG) in the blood.		hp.json	Chronic decreased total IgG in blood	http://purl.obolibrary.org/obo/HP_0032134		
HP:0010785	biolink:PhenotypicFeature	Gonadal neoplasm	A tumor (abnormal growth of tissue) of a gonad.	UMLS:C4021228|NCIT:C3262	hp.json	Gonadal neoplasia	http://purl.obolibrary.org/obo/HP_0010785		
HP:0032135	biolink:PhenotypicFeature	Decreased circulating IgG subclass level	A reduction below the normal concentration of a subclass of immunoglobulin G (IgG) in the blood.		hp.json	Decreased IgG subclass level in blood	http://purl.obolibrary.org/obo/HP_0032135		
HP:0010784	biolink:PhenotypicFeature	Uterine neoplasm	A tumor (abnormal growth of tissue) of the uterus.	MSH:D014594|SNOMEDCT_US:126908007|NCIT:C3262|UMLS:C0042138	hp.json	Uterine neoplasia|Uterine tumor|Uterine tumour|Uterine cancer	http://purl.obolibrary.org/obo/HP_0010784		
HP:0032136	biolink:PhenotypicFeature	Decreased circulating IgG1 level	A reduction in immunoglobulin levels of the IgG1 subclass in the blood circulation.		hp.json	Decreased IgG1 level in blood	http://purl.obolibrary.org/obo/HP_0032136		
HP:0032137	biolink:PhenotypicFeature	Decreased circulating IgG3 level	A reduction in immunoglobulin levels of the IgG3 subclass in the blood circulation.		hp.json	Decreased IgG3 level in blood	http://purl.obolibrary.org/obo/HP_0032137		
HP:0010783	biolink:PhenotypicFeature	Erythema	Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin.	SNOMEDCT_US:444827008|MSH:D004890|SNOMEDCT_US:271811009|MSH:D005483|SNOMEDCT_US:20255002|UMLS:C0041834|SNOMEDCT_US:70819003|SNOMEDCT_US:238810007|SNOMEDCT_US:247441003|UMLS:C0016382|SNOMEDCT_US:86735004	hp.json	Redness of skin or mucous membrane	http://purl.obolibrary.org/obo/HP_0010783		hposlim_core
HP:0010782	biolink:PhenotypicFeature	Shoulder dimple	A subtype of skin dimples occurring in the shoulder region.	UMLS:C4023704	hp.json	Shoulder dimples|Acromial dimple|Bi-acromial dimples	http://purl.obolibrary.org/obo/HP_0010782		
HP:0032130	biolink:PhenotypicFeature	Mycobacterium abscessus abscessus infection	Mycobacterium abscessus complex comprises a group of rapidly growing, multidrug-resistant, nontuberculous mycobacteria that are responsible for a wide spectrum of skin and soft tissue diseases, central nervous system infections, bacteremia, and ocular and other infections.		hp.json		http://purl.obolibrary.org/obo/HP_0032130		
HP:0010781	biolink:PhenotypicFeature	Skin dimple	Skin dimples are cutaneous indentations that are the result of tethering of the skin to underlying structures (bone) causing an indentation.	SNOMEDCT_US:301854006|UMLS:C0578531	hp.json	Skin dimples	http://purl.obolibrary.org/obo/HP_0010781		
HP:0032131	biolink:PhenotypicFeature	Cervical dysplasia	Cervical dysplasia is the precursor to cervical cancer. It is caused by the persistent infection of the human papillomavirus (HPV) into the cervical tissue. Affected cells develop morphologic features with immature basaloid- type squamous cells and mitotic figures in the upper half of the cervical epithelium.		hp.json		http://purl.obolibrary.org/obo/HP_0032131		
HP:0010780	biolink:PhenotypicFeature	Hyperacusis	Over-sensitivity to certain frequency ranges of sound.	SNOMEDCT_US:194399009|MSH:D012001|SNOMEDCT_US:25289003|UMLS:C0034880	hp.json	Sensitivity to noise|Loudness intolerance	http://purl.obolibrary.org/obo/HP_0010780		hposlim_core
HP:0032132	biolink:PhenotypicFeature	Decreased circulating total IgG	A reduction beneath the normal level of total immunoglobulin G (IgG) in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0032132		
HP:0032133	biolink:PhenotypicFeature	Transient decreased circulating total IgG	A temporary reduction beneath the normal level of total immunoglobulin G (IgG) in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0032133		
HP:0032138	biolink:PhenotypicFeature	Decreased circulating IgG4 level	A reduction in immunoglobulin levels of the IgG4 subclass in the blood circulation.		hp.json	Decreased IgG4 level in blood	http://purl.obolibrary.org/obo/HP_0032138		
HP:0032139	biolink:PhenotypicFeature	Reduced isohemagglutinin level	Level of isohemagglutinin reduced below expected concentration. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person).		hp.json	Partial absence of isohemagglutinins|Decreased natural antibody to blood group agents	http://purl.obolibrary.org/obo/HP_0032139		
HP:0010789	biolink:PhenotypicFeature	Abnormality of the Leydig cells		UMLS:C4023703	hp.json		http://purl.obolibrary.org/obo/HP_0010789		
HP:0009789	biolink:PhenotypicFeature	Perianal abscess	The presence of an abscess located around the anus.	UMLS:C0031019|SNOMEDCT_US:82127005	hp.json		http://purl.obolibrary.org/obo/HP_0009789		
HP:0010788	biolink:PhenotypicFeature	Testicular neoplasm	The presence of a neoplasm of the testis.	UMLS:C0039590|SNOMEDCT_US:126900000|NCIT:C3262|MSH:D013736	hp.json	Testicular neoplasia|Testicular tumor|Testicular tumour|Testicular cancer	http://purl.obolibrary.org/obo/HP_0010788		
HP:0007129	biolink:PhenotypicFeature	Cerebellar medulloblastoma		UMLS:C4024934	hp.json		http://purl.obolibrary.org/obo/HP_0007129		
HP:0010787	biolink:PhenotypicFeature	Genital neoplasm	A tumor (abnormal growth of tissue) of the genital system.	UMLS:C4020767|UMLS:C0679347|NCIT:C3262	hp.json	Genital neoplasia|Genital tumor|Genital tumour	http://purl.obolibrary.org/obo/HP_0010787		
HP:0009786	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the musculature of the thigh	Absence or underdevelopment involving the musculature of the thigh.	UMLS:C4024207	hp.json	Absent/small thigh muscles|Absent/underdeveloped thigh muscles	http://purl.obolibrary.org/obo/HP_0009786		
HP:0007123	biolink:PhenotypicFeature	Subcortical dementia	A particular type of dementia characterized by a pattern of mental defects consisting prominently of forgetfulness, slowness of thought processes, and personality or mood change.	UMLS:C4024935	hp.json		http://purl.obolibrary.org/obo/HP_0007123		
HP:0020101	biolink:PhenotypicFeature	Invasive fungal infection	Fungal infection characterized by invasion of host tissues.		hp.json		http://purl.obolibrary.org/obo/HP_0020101		
HP:0009785	biolink:PhenotypicFeature	Triceps aplasia	Absence of the triceps muscle.	UMLS:C3810484	hp.json	Absent triceps	http://purl.obolibrary.org/obo/HP_0009785		
HP:0020100	biolink:PhenotypicFeature	Unusual fungal infection	An unusual fungal infection that is regarded as a sign of a pathological susceptibility to infection by a fungal agent.		hp.json		http://purl.obolibrary.org/obo/HP_0020100		
UBERON:0000323	biolink:AnatomicalEntity	late embryo	An embryo that is at the late embryonic stage; this stage covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching.	EFO:0001323|MESH:D005333|FMA:63919|UMLS:C0015965|GAID:552|BTO:0000449|OpenCyc:Mx4rvZfC2ZwpEbGdrcN5Y29ycA|CALOHA:TS-0360|FBbt:00005333|NCIT:C13235	hp.json	embryo late stage|fetus|embryo late growth stage	http://purl.obolibrary.org/obo/UBERON_0000323		pheno_slim|efo_slim
HP:0009788	biolink:PhenotypicFeature	Quadriceps aplasia	Absence of the quadriceps muscle.	UMLS:C3805765	hp.json	Absent quads	http://purl.obolibrary.org/obo/HP_0009788		
HP:0020103	biolink:PhenotypicFeature	Invasive pulmonary aspergillosis	Infection of the lungs with aspergillus. In the respiratory mucosa, the spores may germinate into hyphae, which in turn can invade the mucosa leading to invasive pulmonary aspergillosis.		hp.json		http://purl.obolibrary.org/obo/HP_0020103		
HP:0007126	biolink:PhenotypicFeature	Proximal amyotrophy	Amyotrophy (muscular atrophy) affecting the proximal musculature.	UMLS:C1850794	hp.json	Proximal muscle atrophy|Wasting of muscles near the body|Symmetrical, proximal limb muscle atrophy|Muscle atrophy, proximal|Proximal muscle wasting|Symmetric proximal muscular atrophy	http://purl.obolibrary.org/obo/HP_0007126		
HP:0009787	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the quadriceps	Absence or underdevelopment of the quadriceps muscle.	UMLS:C4024206	hp.json	Absent/underdeveloped quadriceps|Absent/small quadriceps	http://purl.obolibrary.org/obo/HP_0009787		
HP:0020102	biolink:PhenotypicFeature	Pneumocystis jirovecii pneumonia	An opportunistic disease caused by invasion of unicellular fungus Pneumocystis jirovecii. Transmission of P. jirovecii cysts takes place through the airborne route, and usually, its presence in lungs is asymptomatic. However, people with impaired immunity, especially those with CD4+ T cell count below 200/microliter, are still at risk of the development of Pneumocystis pneumonia due to P. jirovecii invasion. Symptoms induced by this disease are not specific: progressive dyspnoea, non-productive cough, low-grade fever, arterial partial pressure of oxygen below 65 mmHg, and chest radiographs demonstrating bilateral, interstitial shadowing.		hp.json		http://purl.obolibrary.org/obo/HP_0020102		
HP:0009782	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the biceps	Absence or underdevelopment of the biceps muscle.	UMLS:C4024209	hp.json	Absent/small biceps|Absent/underdeveloped biceps	http://purl.obolibrary.org/obo/HP_0009782		
HP:0009781	biolink:PhenotypicFeature	Lester's sign	A zone of darker pigmentation around the central part of the iris with a roughly cloverleaf or flower shape.	UMLS:C4024210	hp.json		http://purl.obolibrary.org/obo/HP_0009781		
HP:0009784	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the triceps	Absence or underdevelopment of the triceps muscle.	UMLS:C4024208	hp.json	Absent/underdeveloped triceps|Absent/small triceps	http://purl.obolibrary.org/obo/HP_0009784		
UBERON:0000320	biolink:AnatomicalEntity	duodenal mucosa	A mucosa that is part of a duodenum [Automatically generated definition].	FMA:14942|CALOHA:TS-0213|MA:0003207|EMAPA:27235|BTO:0000367	hp.json	mucosa of duodenum|doudenal mucosa|mucous membrane of duodenum|duodenum mucosa|duodenal mucous membrane	http://purl.obolibrary.org/obo/UBERON_0000320		human_reference_atlas
HP:0009783	biolink:PhenotypicFeature	Biceps aplasia	Absence of the biceps muscle.	UMLS:C3805764	hp.json	Absent biceps	http://purl.obolibrary.org/obo/HP_0009783		
UBERON:0000307	biolink:AnatomicalEntity	blastula	Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.	BTO:0000128|OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg|BILA:0000059|Wikipedia:Blastula|GAID:1294|OGEM:000006|MESH:D036703	hp.json	blastosphere|blastula embryo|blastosphere	http://purl.obolibrary.org/obo/UBERON_0000307		inconsistent_with_fma
CHEBI:76956	biolink:ChemicalSubstance	Aspergillus metabolite	Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus.		hp.json	Aspergillus metabolites	http://purl.obolibrary.org/obo/CHEBI_76956		3_STAR
UBERON:0000309	biolink:AnatomicalEntity	body wall	The external portion of an animal body derived from ectoderm and mesoderm layers that encloses the body cavity.	galen:BodyWall|FMA:10427|BTO:0000139|EMAPA:32761	hp.json	wall of trunk|wall fo trunk|trunk wall	http://purl.obolibrary.org/obo/UBERON_0000309		pheno_slim
HP:0032140	biolink:PhenotypicFeature	Decreased specific antibody response to vaccination	A reduced ability to synthesize postvaccination antibodies against toxoids and polysaccharides in vaccines, as measured by antibody titer determination following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0032140		
UBERON:0000303	biolink:AnatomicalEntity	adductor longus	An adductor muscle that attaches to the hip and femur. In humans, it is a part of the adductor group of the thigh, that as the name suggests adducts the thigh. The adductor longus muscle forms the medial wall of the femoral triangle[WP, generalized].	BTO:0000029|AAO:0010034|FMA:22441|EMAPA:36220	hp.json	long adductor muscle|musculus adductor longus|musculus adductor longus|adductor longus muscle	http://purl.obolibrary.org/obo/UBERON_0000303		pheno_slim
UBERON:0000304	biolink:AnatomicalEntity	tendon sheath	A layer of membrane around a tendon. It has 2 layers: synovial sheath + fibrous tendon sheath.	Wikipedia:Tendon_sheath|SCTID:361885006|UMLS:C0224856|BTO:0000051|FMA:45087|FMA:76715|NCIT:C96299	hp.json	vagina tendinis|synovial tendon sheath|vagina tendinis	http://purl.obolibrary.org/obo/UBERON_0000304		
UBERON:0000305	biolink:AnatomicalEntity	amnion	The thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected.	FMA:80223|EHDAA:136|MESH:D000650|NCIT:C12365|EV:0100122|VHOG:0000721|GAID:1298|EMAPA:16109|BTO:0000065|UMLS:C0002630|CALOHA:TS-0033|EHDAA2:0000116	hp.json	amnios	http://purl.obolibrary.org/obo/UBERON_0000305		pheno_slim
HP:0010775	biolink:PhenotypicFeature	Vascular ring	A developmental defect of the aortic arch system in which the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches. This occurs if the normal process of regression and persistence of the bilateral embryonic aortic arches fails.	SNOMEDCT_US:110409004|UMLS:C0221214|SNOMEDCT_US:66403007|Fyler:2760	hp.json	Vascular ring of aorta	http://purl.obolibrary.org/obo/HP_0010775		
HP:0032145	biolink:PhenotypicFeature	Sural nerve atrophy	Wasting of the sural nerve, a sensory nerve in the calf region of the leg.		hp.json	Atrophy of sural nerve	http://purl.obolibrary.org/obo/HP_0032145		
HP:0010774	biolink:PhenotypicFeature	Cor triatriatum	The presence of an additional membrane in the left or right cardiac atrium which results in the subdivision of the affected atrium (and thus in total three atria, whence the name).	Fyler:3031|ICD-10:Q24.2|UMLS:C4023708	hp.json	Triatrial heart	http://purl.obolibrary.org/obo/HP_0010774		
HP:0032146	biolink:PhenotypicFeature	HbC hemoglobin	Presence of an abnormal type of hemoglobin characterized by the subsitution of a glutamic acid residue at position 7 following the initial methionine residue by a lysine (6GAG>6AAG). The presence of HbC can be determined by hemoglobin electrophoresis.		hp.json	HbC haemoglobin|Hemoglobin C|Haemoglobin C	http://purl.obolibrary.org/obo/HP_0032146		
HP:0032147	biolink:PhenotypicFeature	Erythromelalgia	Recurrent episodes of redness, burning pain, and warmth of the extremities following exposure to heat or exercise with symptoms predominantly involving the feet.		hp.json		http://purl.obolibrary.org/obo/HP_0032147		
HP:0010773	biolink:PhenotypicFeature	Partial anomalous pulmonary venous return	A form of anomalous pulmonary venous return in which not all pulmonary veins drain abnormally. Partial anomalous pulmonary venous return frequently involves one or both of the veins from one lung.	Fyler:2030|UMLS:C0158634|SNOMEDCT_US:68237008	hp.json	Partial anomalous pulmonary venous connection	http://purl.obolibrary.org/obo/HP_0010773		
HP:0010772	biolink:PhenotypicFeature	Anomalous pulmonary venous return	A developmental defect characterized by abnormal connection of one or more pulmonary veins to the superior or inferior vena cava, the right atrium, or the coronary sinus, resulting in a left-to-right shunt of oxygenated blood.	SNOMEDCT_US:39905002|MSH:D012587|SNOMEDCT_US:111323005|UMLS:C0036400	hp.json		http://purl.obolibrary.org/obo/HP_0010772		
HP:0032148	biolink:PhenotypicFeature	Episodic pain	Intermittent pain, i.e., pain that occurs occasionally and at irregular intervals.		hp.json		http://purl.obolibrary.org/obo/HP_0032148		
HP:0032141	biolink:PhenotypicFeature	Precordial pain	A type of chest pain that arises in the or under the left breast and often described as throbbing, stabbing, or burning, and lasting hours or longer. The pain may arise with or after effort, and may spread to the left arm or left side of the neck.		hp.json		http://purl.obolibrary.org/obo/HP_0032141		
HP:0010771	biolink:PhenotypicFeature	Pilonidal abscess	A hair-containing cyst or sinus usually in the coccygeal region.	UMLS:C3537055|SNOMEDCT_US:85224001	hp.json	Sacrococcygeal fistula	http://purl.obolibrary.org/obo/HP_0010771		
HP:0032142	biolink:PhenotypicFeature	Fetor hepaticus	Fetor hepaticus is the characteristic breath of patients with severe parenchymal liver disease, which has been said to resemble the odor of a mixture of rotten eggs and garlic.		hp.json	Foetor hepaticus	http://purl.obolibrary.org/obo/HP_0032142		
HP:0010770	biolink:PhenotypicFeature	Pilonidal fistula		UMLS:C0031925|SNOMEDCT_US:47639008|MSH:D010864	hp.json		http://purl.obolibrary.org/obo/HP_0010770		
HP:0032143	biolink:PhenotypicFeature	Burning mouth	An intense sensation of burning, scalding, or tingling feeling of the tongue or other regions of the oral mucosa.		hp.json		http://purl.obolibrary.org/obo/HP_0032143		
HP:0032144	biolink:PhenotypicFeature	Coffee ground vomitus	Vomit that has the appearance of coffee grounds, which occurs due to the presence of coagulated blood in the vomit.		hp.json	Coffee grounds emesis|Coffee grounds vomiting	http://purl.obolibrary.org/obo/HP_0032144		
UBERON:0014950	biolink:AnatomicalEntity	layer of developing cerebral cortex			hp.json		http://purl.obolibrary.org/obo/UBERON_0014950		
CL:1000223	biolink:Cell	lung neuroendocrine cell			hp.json		http://purl.obolibrary.org/obo/CL_1000223		
CL:1000222	biolink:Cell	stomach neuroendocrine cell			hp.json		http://purl.obolibrary.org/obo/CL_1000222		
HP:0010779	biolink:PhenotypicFeature	Large pelvis bone	The presence of an abnormally large pelvis.	UMLS:C4072882|UMLS:C4019074	hp.json	Large pelvis|Large pelvis bone	http://purl.obolibrary.org/obo/HP_0010779		hposlim_core
HP:0032149	biolink:PhenotypicFeature	Breakthrough pain	A episode of severe pain that breaks through (i.e., temporarily exacerbates) a period of persistent pain.		hp.json		http://purl.obolibrary.org/obo/HP_0032149		
HP:0010778	biolink:PhenotypicFeature	Tracheomegaly	Marked widening of the trachea.	UMLS:C4023705	hp.json		http://purl.obolibrary.org/obo/HP_0010778		
HP:0010777	biolink:PhenotypicFeature	Bronchomegaly	Marked widening of the major bronchi that may be predispose to chronic respiratory tract infection.	UMLS:C4023706	hp.json		http://purl.obolibrary.org/obo/HP_0010777		
HP:0010776	biolink:PhenotypicFeature	Tracheobronchmegaly	Marked widening of the trachea and major bronchi that may be predispose to chronic respiratory tract infection.	UMLS:C4023707	hp.json		http://purl.obolibrary.org/obo/HP_0010776		
UBERON:0000310	biolink:AnatomicalEntity	breast	The upper ventral region of the torso of an organism.	CALOHA:TS-2083|GAID:33|OpenCyc:Mx4rvVjV7ZwpEbGdrcN5Y29ycA|UMLS:C0006141|FMA:9601|galen:Breast|MESH:D001940|EV:0100124|NCIT:C12971|BTO:0000149	hp.json	mammary region|mamma|mammary part of chest	http://purl.obolibrary.org/obo/UBERON_0000310		pheno_slim
HP:0009797	biolink:PhenotypicFeature	Cholesteatoma	Cholesteatoma is a benign but potentially destructive growth consisting of keratinizing epithelium located in the middle ear and/or mastoid process. In cholesteatoma, a skin cyst grows into the middle ear and mastoid. The cyst is not cancerous but can erode tissue and cause destruction of the ear.	SNOMEDCT_US:363668000|UMLS:C0008373|MSH:D002781|SNOMEDCT_US:575006	hp.json		http://purl.obolibrary.org/obo/HP_0009797		
HP:0009796	biolink:PhenotypicFeature	Branchial cyst	A branchial cyst is a remnant of embryonic development resulting from a failure of obliteration of a branchial cleft and consists of a subcutaneous cystic mass. Cysts are located anterior or posterior to the ear or in the submandibular region.	UMLS:C0006131|SNOMEDCT_US:42362005|SNOMEDCT_US:59857007|MSH:D001935	hp.json	Branchial cleft cyst|Branchial cysts	http://purl.obolibrary.org/obo/HP_0009796		
UBERON:0000311	biolink:AnatomicalEntity	extensor muscle	A skeletal muscle whose contraction extends or stretches a body part.	FMA:75000|BTO:0000151	hp.json	extensor	http://purl.obolibrary.org/obo/UBERON_0000311		pheno_slim
HP:0009799	biolink:PhenotypicFeature	Supernumerary spleens	The presence of two or more accessory spleens.	SNOMEDCT_US:10362008|UMLS:C0266631	hp.json	Extra spleen	http://purl.obolibrary.org/obo/HP_0009799		
HP:0009798	biolink:PhenotypicFeature	Euthyroid goiter	A goiter that is not associated with functional thyroid abnormalities.	SNOMEDCT_US:32251000119106|MSH:C562732|UMLS:C0302859	hp.json	Euthyroid goitre	http://purl.obolibrary.org/obo/HP_0009798		
UBERON:0000313	biolink:AnatomicalEntity	portion of cartilage tissue in tibia	Cartilage pertaining to the tibia.	BTO:0000207|FMA:33923	hp.json	tibial cartilage|cartilage of tibia	http://purl.obolibrary.org/obo/UBERON_0000313		
HP:0009793	biolink:PhenotypicFeature	Presacral teratoma	A type of sacrococcygeal teratoma located anterior to the sacrum and entirely inside the body (Altman type IV).	UMLS:C1867782	hp.json	Retrorectal teratoma|Altman type IV sacrococcygeal teratoma	http://purl.obolibrary.org/obo/HP_0009793		
HP:0009792	biolink:PhenotypicFeature	Teratoma	The presence of a teratoma.	MSH:D013724|SNOMEDCT_US:55818009|NCIT:C3403|UMLS:C0039538	hp.json		http://purl.obolibrary.org/obo/HP_0009792		
HP:0007131	biolink:PhenotypicFeature	Acute demyelinating polyneuropathy	Acute progressive areflexic weakness and mild sensory changes resulting from myelin breakdown and axonal degeneration.	UMLS:C4024933	hp.json		http://purl.obolibrary.org/obo/HP_0007131		
HP:0009795	biolink:PhenotypicFeature	Branchial fistula	A congenital fistula in the neck resulting from incomplete closure of a branchial cleft.	SNOMEDCT_US:204268008|UMLS:C0546968	hp.json	Branchial cleft fistula	http://purl.obolibrary.org/obo/HP_0009795		hposlim_core
HP:0007132	biolink:PhenotypicFeature	Pallidal degeneration	Neurodegeneration involving the globus pallidus,a part of the basal ganglia that is involved in the regulation of voluntary movement.	UMLS:C0393577|SNOMEDCT_US:230302004	hp.json		http://purl.obolibrary.org/obo/HP_0007132		
HP:0007133	biolink:PhenotypicFeature	Progressive peripheral neuropathy		UMLS:C1859178	hp.json	Progressive polyneuropathy	http://purl.obolibrary.org/obo/HP_0007133		
HP:0009794	biolink:PhenotypicFeature	Branchial anomaly	Congenital developmental defect arising from the primitive branchial apparatus.	UMLS:C1862066	hp.json	Branchial anomalies|Abnormality of branchial apparatus|Abnormality of branchial arch|Branchial abnormality	http://purl.obolibrary.org/obo/HP_0009794		hposlim_core
HP:0007193	biolink:PhenotypicFeature	Bilateral tonic-clonic seizure on awakening	Bilateral tonic-clonic seizure of either generalized or focal onset occurring on or soon after wakening (typically within 90 minutes of waking, regardless of the time of day).	UMLS:C1847165	hp.json	Generalised tonic-clonic seizures on awakening|Generalized tonic-clonic seizures on awakening|Morning generalised tonic-clonic seizures|Morning generalized tonic-clonic seizures	http://purl.obolibrary.org/obo/HP_0007193		
CHEBI:76967	biolink:ChemicalSubstance	human xenobiotic metabolite	Any human metabolite produced by metabolism of a xenobiotic compound in humans.		hp.json	human xenobiotic metabolites	http://purl.obolibrary.org/obo/CHEBI_76967		3_STAR
UBERON:0012361	biolink:AnatomicalEntity	internal anal region		EHDAA2:0004588	hp.json		http://purl.obolibrary.org/obo/UBERON_0012361		
UBERON:0012360	biolink:AnatomicalEntity	bone of jaw	A bone element that is part of a jaw region.	SCTID:369003004|MA:0003130|EMAPA:35453	hp.json	jaw bone	http://purl.obolibrary.org/obo/UBERON_0012360		
HP:0007190	biolink:PhenotypicFeature	Neuronal loss in the cerebral cortex		UMLS:C1849485	hp.json		http://purl.obolibrary.org/obo/HP_0007190		
CHEBI:76969	biolink:ChemicalSubstance	bacterial metabolite	Any prokaryotic metabolite produced during a metabolic reaction in bacteria.		hp.json		http://purl.obolibrary.org/obo/CHEBI_76969		3_STAR
UBERON:0012367	biolink:AnatomicalEntity	muscle layer of intestine	A muscle layer that is part of an intestine.	FMA:15697	hp.json	intestinal muscularis propria|smooth muscle of intestine|muscularis externa of intestine	http://purl.obolibrary.org/obo/UBERON_0012367		
CHEBI:15966	biolink:ChemicalSubstance	D-glutamic acid	An optically active form of glutamic acid having D-configuration.	CAS:6893-26-1|Beilstein:1723800|Reaxys:1723800|Gmelin:201189|KEGG:C00217|MetaCyc:D-GLT|CAS:6893-26-1|PDBeChem:DGL|CAS:6893-26-1|KNApSAcK:C00019577|DrugBank:DB02517|HMDB:HMDB0003339	hp.json	D-Glutamic acid|(R)-2-aminopentanedioic acid|(2R)-2-aminopentanedioic acid|D-Glutaminsaeure|glutamic acid D-form|DGL|D-Glutaminic acid|D-glutamic acid|D-2-Aminoglutaric acid	http://purl.obolibrary.org/obo/CHEBI_15966		3_STAR
HP:0020161	biolink:PhenotypicFeature	Branch retinal artery occlusion	Blockage of a branch of the retinal artery. This can cause loss of a section of visual field.		hp.json		http://purl.obolibrary.org/obo/HP_0020161		
UBERON:0000382	biolink:AnatomicalEntity	apocrine sweat gland	Apocrine sweat glands are sweat glands composed of a coiled secretory portion located at the junction of the dermis and subcutaneous fat, from which a straight portion inserts and secretes into the infundibular portion of the hair follicle. The ducts of apocrine glands open into the canals of hair follicles. The stimulus for the secretion of apocrine sweat glands is adrenaline, which is a hormone carried in the blood[WP].	EMAPA:37426|BTO:0001458|NCIT:C32132|MESH:D001050|UMLS:C0930083|FMA:59155	hp.json	glandula sudorifera apocrina	http://purl.obolibrary.org/obo/UBERON_0000382		organ_slim|pheno_slim
HP:0020160	biolink:PhenotypicFeature	GM1-ganglioside accumulation	Cellular accumulation of GM1 gangliosides.		hp.json		http://purl.obolibrary.org/obo/HP_0020160		
UBERON:0012359	biolink:AnatomicalEntity	pedal digitopodium bone	A bone that is part of a the pedal digitopodium skeleton - i.e. the toes or the metatarsal skeleton.		hp.json	bone of hindlimb digitopodium	http://purl.obolibrary.org/obo/UBERON_0012359		
CHEBI:15963	biolink:ChemicalSubstance	ribitol	A pentitol (five-carbon sugar alcohol) having meso-configuration, being derived from ribose by reduction of the carbonyl group. It occurs naturally in the plant Adonis vernalis.	PMID:23564164|PMID:17979222|PMID:25108762|PMID:24643482|PMID:15234337|HMDB:HMDB0000508|PMID:17336832|CAS:488-81-3|MetaCyc:RIBITOL|Wikipedia:Ribitol|Gmelin:82894|KEGG:C00474|PMID:16664320|CAS:488-81-3|PMID:16901854|CAS:488-81-3|Beilstein:1720524|KNApSAcK:C00001171|Reaxys:1720524	hp.json	(2R,3s,4S)-pentane-1,2,3,4,5-pentol|L-ribitol|D-Ribitol|Adonitol|Ribitol|meso-ribitol|D-Adonitol|ribitol|(2R,3s,4S)-pentane-1,2,3,4,5-pentol	http://purl.obolibrary.org/obo/CHEBI_15963		3_STAR
HP:0020167	biolink:PhenotypicFeature	Hemiretinal vein occlusion	A variant of central retinal vein occlusions that involves the superior or inferior half of the retina.		hp.json		http://purl.obolibrary.org/obo/HP_0020167		
UBERON:0000388	biolink:AnatomicalEntity	epiglottis	A part of the pharynx that consists of a flap of elastic cartilage tissue plus a mucous membrane covering, attached to the entrance of the larynx. The epiglottis is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink[MP,modified].	BTO:0001628|MESH:D004825|FMA:55130|UMLS:C0014540|EHDAA2:0004081|GAID:111|EMAPA:18289|NCIT:C12709|OpenCyc:Mx4rvVjxE5wpEbGdrcN5Y29ycA	hp.json		http://purl.obolibrary.org/obo/UBERON_0000388		pheno_slim
HP:0020166	biolink:PhenotypicFeature	Central retinal vein occlusion	Central retinal vein occlusion is an occlusion of the main retinal vein posterior to the lamina cribrosa of the optic nerve and is typically caused by thrombosis.		hp.json		http://purl.obolibrary.org/obo/HP_0020166		
UBERON:0000389	biolink:AnatomicalEntity	lens cortex	Tissue that surrounds the lens nucleus.	MESH:D007904|SCTID:280626006|BTO:0001632|MESH:A09.371.509.225|CALOHA:TS-0542|FMA:58970	hp.json	cortex of lens	http://purl.obolibrary.org/obo/UBERON_0000389		human_reference_atlas
HP:0020169	biolink:PhenotypicFeature	Abnormal drug response	An anomlous response to a medication related to individual variation in metabolic or immune response to drugs varying from potentially from potentially life-threatening adverse drug reactions to alteration of therapeutic efficacy.		hp.json		http://purl.obolibrary.org/obo/HP_0020169		
HP:0020163	biolink:PhenotypicFeature	Cilioretinal artery occlusion	Blockage of the cilioretinal artery. The central retinal artery supplies the inner retina and the surface of the optic nerve. In some individuals, the cilioretinal artery, a branch of the ciliary circulation, may supply a portion of the retina including the macula. In cilioretinal artery occlusion, vision loss results from cell death in the inner retinal layers (mainly ganglion cells) despite relative sparing of the outer layers.		hp.json		http://purl.obolibrary.org/obo/HP_0020163		
UBERON:0000383	biolink:AnatomicalEntity	musculature of body	The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified].	FBbt:00005069|MAT:0000025|BTO:0001369|XAO:0004042|MIAA:0000025|EMAPA:35578|BTO:0001485|BILA:0000088|VSAO:0000033|MA:0002888|AAO:0000307|EFO:0000801|FMA:72954	hp.json	set of all muscles|muscle system of body|musculature system|set of muscles of body|vertebrate muscular system|muscular system|muskelsystem|muscle system	http://purl.obolibrary.org/obo/UBERON_0000383		pheno_slim|efo_slim
HP:0007185	biolink:PhenotypicFeature	Loss of consciousness		MSH:D014474|SNOMEDCT_US:419045004|SNOMEDCT_US:418107008|UMLS:C0041657	hp.json	Loss of consciousness|Passing out	http://purl.obolibrary.org/obo/HP_0007185		
HP:0020165	biolink:PhenotypicFeature	Branch retinal vein occlusion	Blockage of a branch of the retinal vein. It may present with sudden-onset of painless vision loss or visual field defect correlating to the area of perfusion of the obstructed vessels.		hp.json		http://purl.obolibrary.org/obo/HP_0020165		
HP:0007187	biolink:PhenotypicFeature	Focal lissencephaly	A congenital absence of the convolutions of the cerebral cortex and a poorly formed sylvian fissure that affects a particular part of the cortex.	UMLS:C1855230	hp.json		http://purl.obolibrary.org/obo/HP_0007187		
HP:0020164	biolink:PhenotypicFeature	Ophthalmic artery occlusion	A partial or complete obstruction of the ophthalmic artery (branch of the internal carotid artery) that may lead to severe ischemia of the affected globe and associated ocular tissues. It can present with a similar picture to central retinal artery occlusion; however, profound choroidal ischaemia also occurs.		hp.json		http://purl.obolibrary.org/obo/HP_0020164		
HP:0007188	biolink:PhenotypicFeature	Congenital facial diplegia	Facial diplegia (that is, bilateral facial palsy) with congenital onset.	MSH:C531747|UMLS:C0853240	hp.json	Congenital bilateral facial palsy|Congenital bilateral facial weakness	http://purl.obolibrary.org/obo/HP_0007188		
UBERON:0000369	biolink:AnatomicalEntity	corpus striatum	The corpus striatum (striated body) is a compound structure consisting of the caudate nucleus and the lentiform nucleus, which consists of the putamen and the globus pallidus[WP].	GAID:667|UMLS:C0010097|EFO:0000381|NCIT:C12448|VHOG:0001175|FMA:77616|CALOHA:TS-0183|EHDAA2:0000596|MESH:D003342|BTO:0001311|EMAPA:17549|EV:0100184|BAMS:CSTR	hp.json	striated body|striate body	http://purl.obolibrary.org/obo/UBERON_0000369		efo_slim
HP:0020159	biolink:PhenotypicFeature	Reduced response to gonadotropin-releasing hormone stimulation test	Failure of the gonadotropin-releasing hormone (GnRH) stimulation test to induce an appropriate increased in luteinizing hormone (LH), follicle-stimulating hormone (FSH) levels.		hp.json	Reduce response to GnRH stimulation test	http://purl.obolibrary.org/obo/HP_0020159		
UBERON:0012354	biolink:AnatomicalEntity	acropodium region	The segment of the autopod that is distal to the metapodial region and consists of the digits.		hp.json	set of digits|acropodial segment of autopod|acropodial limb segment|acropodial region	http://purl.obolibrary.org/obo/UBERON_0012354		
UBERON:0012351	biolink:AnatomicalEntity	urachal lumen	An anatomical space that is enclosed by a urachus.		hp.json	urachus lumen	http://purl.obolibrary.org/obo/UBERON_0012351		
UBERON:0012358	biolink:AnatomicalEntity	manual digitopodium bone	A bone that is part of a the manual digitopodium skeleton - i.e. the fingers or the metacarpal skeleton.		hp.json	bone of forelimb digitopodium	http://purl.obolibrary.org/obo/UBERON_0012358		
UBERON:0012357	biolink:AnatomicalEntity	digitopodium bone	A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton.		hp.json	digit bone	http://purl.obolibrary.org/obo/UBERON_0012357		
UBERON:0012356	biolink:AnatomicalEntity	pedal acropodium region	The segment of the pes that is distal to the metatarsal region and consists of the pedal digits (toes).	FMA:70664	hp.json	toes set|acropodial region of pes|set of toes|toes|all toes|acropodial segment of pes|digits of foot|acropodial forelimb segment|pedal acropodium region	http://purl.obolibrary.org/obo/UBERON_0012356		
UBERON:0012355	biolink:AnatomicalEntity	manual acropodium region	The segment of the manus that is distal to the metacarpal region and consists of the manual digits (fingers).	FMA:75592	hp.json	anterior acropodium segment of limb|set of fingers|anterior acropodium region|manual acropodium|digits of hand|manual acropodium region|acropodial segment of manus|anterior acropodium|fingers set|acropodial hindlimb segment|all fingers|set of digits of hand|acropodial region of manus|digiti manus|fingers including thumb|manual acropodium segment of limb	http://purl.obolibrary.org/obo/UBERON_0012355		
HP:0020150	biolink:PhenotypicFeature	Elevated urinary uromodulin	An increased amount of uromodulin (also known as Tamm Horsfall protein) in the urine.		hp.json	Elevated urinary Tamm-Horsfall protein concentration	http://purl.obolibrary.org/obo/HP_0020150		
OBO:hp#abbreviation	biolink:NamedThing	abbreviation			hp.json		http://purl.obolibrary.org/obo/hp#abbreviation		
UBERON:0000376	biolink:AnatomicalEntity	hindlimb stylopod	The part of the hindlimb between pelvis and the knee, corresponding to the femur.	EHDAA:5171|EMAPA:17499|NCIT:C33763|EFO:0001943|UMLS:C0039866|OpenCyc:Mx4rvVjN7JwpEbGdrcN5Y29ycA|FMA:24967|VHOG:0000349|galen:Thigh|MA:0000052|EHDAA:6200|BTO:0001376|EHDAA2:0002130|CALOHA:TS-2039|MESH:D013848|GAID:50	hp.json	hind limb stylopod|stylopod of hindlimb|upper leg|hind limb stylopodium|femur|stylopod of hind limb|proximal segment of free lower limb|hindlimb propodium|hind propodium|thigh|stylopod of lower limb|hindlimb stylopod|hindlimb stylopodium	http://purl.obolibrary.org/obo/UBERON_0000376		pheno_slim|efo_slim
HP:0020156	biolink:PhenotypicFeature	Abnormal zona pellucida morphology	Abnormal structure of the oocyte extracellular matrix region known as teh zona pellucida.		hp.json		http://purl.obolibrary.org/obo/HP_0020156		
HP:0020155	biolink:PhenotypicFeature	Abnormal oocyte morphology	An abnormal structure of the female germ cell (egg cell).		hp.json		http://purl.obolibrary.org/obo/HP_0020155		
UBERON:0000377	biolink:AnatomicalEntity	maxillary nerve	The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses.	SCTID:280211001|MA:0001103|FMA:52724|Wikipedia:Maxillary_nerve|OpenCyc:Mx4rvWNU9JwpEbGdrcN5Y29ycA|BTO:0001378|GAID:836|AAO:0010670|VHOG:0001346|EHDAA2:0002087|EMAPA:17799|MESH:D008442	hp.json	maxillary nerve [V2]|maxillary nerve [Vb]|nervus maxillaris|second division of fifth cranial nerve|maxillary division of fifth cranial nerve|nervus maxillaris [vb]|trigeminal V nerve maxillary division|nervus maxillaris [v2]|ramus maxillaris (ramus V2)|n. maxillaris|maxillary division of trigeminal nerve (Vb; V2)|trigeminal nerve maxillary division|second division of trigeminal nerve|n. maxillaris|nervus maxillaris (Vb; V2)|maxillary division [V2]|maxillary division [Vb]	http://purl.obolibrary.org/obo/UBERON_0000377		pheno_slim|human_reference_atlas
UBERON:0000378	biolink:AnatomicalEntity	tongue muscle	The muscular portion of the tongue.	UMLS:C0448325|EMAPA:17883|Wikipedia:Muscles_of_tongue|SCTID:244781004|MA:0001596|VHOG:0001390|UMLS:C1710437|NCIT:C52707|NCIT:C49301|FMA:46689|EHDAA2:0002065|EHDAA:9146|BTO:0001386	hp.json	musculi linguae|muscle organ of tongue|tongue skeletal muscle|skeletal muscle tissue of tongue|muscle of tongue|tongue skeletal muscle tissue|musculi linguae	http://purl.obolibrary.org/obo/UBERON_0000378		pheno_slim
HP:0020158	biolink:PhenotypicFeature	Increased circulating adrenic acid concentration	An increased concentration of adrenic acid (also known as cis-7,10,13,16-Docosatetraenoic acid) in the blood circulation.		hp.json	Increased circulating docosatetraenoate level	http://purl.obolibrary.org/obo/HP_0020158		
UBERON:0000379	biolink:AnatomicalEntity	tracheal mucosa	A mucosa that is part of a respiratory airway.	BTO:0001390|FMA:7471|SCTID:660006	hp.json	mucosa of windpipe|organ mucosa of windpipe|mucous membrane of windpipe|trachea mucosa|trachea organ mucosa|windpipe mucosa of organ|windpipe mucosa|windpipe organ mucosa|mucous membrane of trachea|organ mucosa of trachea|trachea mucosa of organ|mucosa of trachea|tunica mucosa tracheae|windpipe mucous membrane|trachea mucous membrane|mucosa of organ of trachea|mucosa of organ of windpipe|mucous membrane of trachea|tracheal mucous membrane|tunica mucosa (tracheae)	http://purl.obolibrary.org/obo/UBERON_0000379		
HP:0020157	biolink:PhenotypicFeature	Thin zona pellucida	Reduced thickness of the zona pellucida.		hp.json		http://purl.obolibrary.org/obo/HP_0020157		
HP:0020152	biolink:PhenotypicFeature	Distal joint laxity	Lack of stability of a distal joint (e.g., finger).		hp.json		http://purl.obolibrary.org/obo/HP_0020152		
HP:0020151	biolink:PhenotypicFeature	Anti-dsDNA antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against double-stranded DNA.		hp.json		http://purl.obolibrary.org/obo/HP_0020151		
CHEBI:76971	biolink:ChemicalSubstance	Escherichia coli metabolite	Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.		hp.json	E.coli metabolite|Escherichia coli metabolites|E.coli metabolites	http://purl.obolibrary.org/obo/CHEBI_76971		3_STAR
HP:0020154	biolink:PhenotypicFeature	Nevus comedonicus	A type of epidermal nevus characterized by closely arranged, dilated follicular openings with keratinous plugs resembling classical comedones.		hp.json		http://purl.obolibrary.org/obo/HP_0020154		
HP:0007199	biolink:PhenotypicFeature	Progressive spastic paraparesis		UMLS:C0747251	hp.json		http://purl.obolibrary.org/obo/HP_0007199		
UBERON:0000375	biolink:AnatomicalEntity	mandibular nerve	The motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini.	MESH:D008340|AAO:0010688|MA:0001101|Wikipedia:Mandibular_nerve|FMA:52996|UMLS:C0024695|OpenCyc:Mx4rvcQKSpwpEbGdrcN5Y29ycA|SCTID:280212008|GAID:834|BTO:0001375|VHOG:0001345|EHDAA2:0002086|NCIT:C32779|EMAPA:17798|AAO:0010703	hp.json	nervus mandibularis [Vc; V3]|trigeminal V nerve mandibular division|trigeminal nerve mandibular division|ramus mandibularis (ramus V3)|mandibular division [V3]|mandibular division [Vc]|mandibular nerve [Vc]|mandibular nerve [V3]|nervus mandibularis [vc]|nervus mandibularis [v3]|mandibular division of fifth cranial nerve|n. mandibularis|third division of trigeminal nerve|nervus mandibularis|inferior maxillary nerve|third division of fifth cranial nerve|mandibular division of trigeminal nerve [Vc; V3]|n. mandibularis	http://purl.obolibrary.org/obo/UBERON_0000375		pheno_slim|human_reference_atlas
HP:0020153	biolink:PhenotypicFeature	Positive blood 1,3 beta glucan test	Beta-1,3-glucan is a major constituent of all of the characterized fungal cell walls, making up between 30-80 percent of the mass of the wall. It is a biomarker of fungal infections such as invasive pulmonary aspergillosis.		hp.json		http://purl.obolibrary.org/obo/HP_0020153		
UBERON:0000358	biolink:AnatomicalEntity	blastocyst	The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm[GO].	EV:0100394|UMLS:C1281743|GAID:1153|NCIT:C13739|BTO:0001099|EFO:0000295|FMA:83041|Wikipedia:Blastocyst|EMAPA:36035|CALOHA:TS-0076|SCTID:308837009|MESH:D001755	hp.json	blastocystis|blastula|blastocystis	http://purl.obolibrary.org/obo/UBERON_0000358		efo_slim
HP:0020149	biolink:PhenotypicFeature	Elevated circulating succinate	An increase concentration of succinate in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0020149		
HP:0020148	biolink:PhenotypicFeature	Increased circulating mead acid level	An abnormally elevated concentration od mead acid in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0020148		
UBERON:0012344	biolink:AnatomicalEntity	holocrine gland	Any exocrine gland whose secretion consists of its own disintegrated secretory cells along with its secretory product; holocrine secretions are produced in the cytoplasm of the cell and released by the rupture of the plasma membrane, which destroys the cell and results in the secretion of the product into the lumen.	BTO:0002325|MA:0003042	hp.json		http://purl.obolibrary.org/obo/UBERON_0012344		pheno_slim
CHEBI:15986	biolink:ChemicalSubstance	polynucleotide	A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues.	KEGG:C00419	hp.json	Polynucleotide|polynucleotides	http://purl.obolibrary.org/obo/CHEBI_15986		3_STAR
HP:0020145	biolink:PhenotypicFeature	Calcium oxalate crystalluria	The presence of calcium oxalate crystals in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020145		
UBERON:0000366	biolink:AnatomicalEntity	flexor muscle	A skeletal muscle whose contraction bends a joint.	TAO:0005271|FMA:74559|FMA:74999|BTO:0001257|ZFA:0005271	hp.json	flexor	http://purl.obolibrary.org/obo/UBERON_0000366		vertebrate_core|pheno_slim
HP:0020144	biolink:PhenotypicFeature	Calcium phosphate crystalluria	The presence of calcium phosphate crystals in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020144		
HP:0020147	biolink:PhenotypicFeature	2-Methylbutyryl glycinuria	Increased concentration of 2-methylbutyryl glycine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020147		
HP:0020146	biolink:PhenotypicFeature	Calcium carbonate crystalluria	The presence of calcium carbonate crystals in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020146		
UBERON:0000361	biolink:AnatomicalEntity	red bone marrow	The red vascular substance consisting of connective tissue and blood vessels, containing primitive blood cells, macrophages, megakaryocytes, and fat cells. Red marrow is found in the cavities of many bones. It manufactures and releases leukocytes and erythrocytes into the bloodstream.	SCTID:75330005|BTO:0001160|SCTID:328538003|FMA:74595	hp.json	parenchyma of none marrow marrow|red marrow|parenchyma of none marrow marrow|parenchymal red marrow|medulla ossium rubra|parenchymal red marrow	http://purl.obolibrary.org/obo/UBERON_0000361		
HP:0020141	biolink:PhenotypicFeature	Blood pressure substantially higher in legs than arms	An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the legs being much higher than the blood pressure measure in the arms. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm.		hp.json	Blood pressure substantially higher in lower than upper extremities|Blood pressure substantially lower in upper than lower extremities|Blood pressure substantially lower in arms than legs	http://purl.obolibrary.org/obo/HP_0020141		
HP:0007163	biolink:PhenotypicFeature	obsolete Corticospinal tract disease in lower limbs			hp.json		http://purl.obolibrary.org/obo/HP_0007163		
HP:0020140	biolink:PhenotypicFeature	History of recent tick bite	Medical history of a recent bite injury due to a tick.		hp.json		http://purl.obolibrary.org/obo/HP_0020140		
UBERON:0000362	biolink:AnatomicalEntity	renal medulla	The inner portion of the kidney consisting of the renal pyramids.	galen:MedullaOfKidney|EMAPA:19279|NCIT:C12740|MA:0000373|MESH:D007679|BTO:0001167|GAID:425|UMLS:C0022664|CALOHA:TS-1157	hp.json	renal marrow|medulla of kidney|medulla renalis|renal pyramids set|medullary pyramids|kidney medulla|renal pyramids|renal medullae set|pyramides renales|renal medullae	http://purl.obolibrary.org/obo/UBERON_0000362		pheno_slim|human_reference_atlas
HP:0007164	biolink:PhenotypicFeature	Slowed slurred speech		UMLS:C4024929	hp.json	Slowed slurred speech	http://purl.obolibrary.org/obo/HP_0007164		
HP:0007165	biolink:PhenotypicFeature	Periventricular heterotopia	A form of gray matter heterotopia were the mislocalized gray matter is typically located periventricularly, also sometimes called subependymal heterotopia. Periventricular means beside the ventricles. This is by far the most common location for heterotopia. Subependymal heterotopia present in a wide array of variations. There can be a small single node or a large number of nodes, can exist on either or both sides of the brain at any point along the higher ventricle margins, can be small or large, single or multiple, and can form a small node or a large wavy or curved mass.	UMLS:C1849173	hp.json	Subependymal gray matter heterotopia|Periventricular neuronal heterotopia|Periventricular grey matter heterotopia|Subependymal grey matter heterotopia|Subependymal neuronal heterotopia|Periventricular gray matter heterotopia	http://purl.obolibrary.org/obo/HP_0007165		
HP:0020143	biolink:PhenotypicFeature	Tracheal duplication cyst	A cyst in the trachea, whose wall is made up by tissue similar to the bronchial tree, including cartilage and smooth muscle, and is lined by secretory respiratory epithelium composed of cuboid or columnar ciliated epithelium.		hp.json		http://purl.obolibrary.org/obo/HP_0020143		
HP:0007166	biolink:PhenotypicFeature	Paroxysmal dyskinesia	Episodic bouts of involuntary movements with dystonic, choreic, ballistic movements, or a combination thereof. There is no loss of consciousness during the attacks.	UMLS:C1836174|MSH:D002819|UMLS:C0752210	hp.json	Involuntary dystonic or choreiform movements	http://purl.obolibrary.org/obo/HP_0007166		
HP:0020142	biolink:PhenotypicFeature	Blood pressure substantially higher in arms than legs	An abnormal blood pressure discrepancy between the upper and lower extremities with the blood pressure measured in the arms being much higher than the blood pressure measure in the legs. In healthy individuals, ankle systolic blood pressures are only slightly higher than the systolic blood pressure measured in the arm.		hp.json	Blood pressure substantially higher in upper than lower extremities|Increased arm-leg blood pressure gradient	http://purl.obolibrary.org/obo/HP_0020142		
HP:0007181	biolink:PhenotypicFeature	Interosseus muscle atrophy	Atrophy of the interosseus muscles (including the palmar interossei that lie on the anterior aspect of the metacarpals, the dorsal interosseus muscles of the hand, which lie between the intercarpals, the plantar interosseus muscles, which lie underneath the metatarsal bones, and the dorsal interossei, which are located between the metatarsal bones.	UMLS:C1846829	hp.json	Interosseous muscular atrophy	http://purl.obolibrary.org/obo/HP_0007181		
HP:0007182	biolink:PhenotypicFeature	Peripheral hypomyelination	Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the peripheral nervous system.	UMLS:C4024927	hp.json		http://purl.obolibrary.org/obo/HP_0007182		
HP:0007183	biolink:PhenotypicFeature	Focal T2 hyperintense basal ganglia lesion	A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a localized hyperintensity affecting a particular region of the basal ganglia.	UMLS:C4024926|UMLS:C1865351	hp.json	Hyperintense lesions in the basal ganglia on MRI	http://purl.obolibrary.org/obo/HP_0007183		
CHEBI:74337	biolink:ChemicalSubstance	D-asparagine zwitterion	A D-alpha-amino acid zwitterion that is D-asparagine in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3.		hp.json	(2R)-4-amino-2-ammonio-4-oxobutanoate|D-asparagine|(2R)-4-amino-2-azaniumyl-4-oxobutanoate	http://purl.obolibrary.org/obo/CHEBI_74337		3_STAR
HP:0020138	biolink:PhenotypicFeature	History of recent animal bite	Medical history of a recent bite injury due to an animal.		hp.json		http://purl.obolibrary.org/obo/HP_0020138		
UBERON:0000347	biolink:AnatomicalEntity	entire myelin sheath	The insulating envelope that surrounds nerve fibers or axons.	NCIT:C13261|UMLS:C0026973|GAID:731|MESH:D009186|CALOHA:TS-2363|BTO:0000900|GO:0043209|FMA:62983	hp.json	medullary sheath	http://purl.obolibrary.org/obo/UBERON_0000347		pheno_slim
UBERON:0000348	biolink:AnatomicalEntity	ophthalmic nerve	The sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead.	OpenCyc:Mx4rwEs_K5wpEbGdrcN5Y29ycA|EHDAA2:0002088|EMAPA:17800|AAO:0010648|BTO:0000926|MESH:D009882|MA:0001104|EHDAA:3744|NCIT:C33215|UMLS:C0029082|FMA:52621|GAID:837|VHOG:0001349	hp.json	profundal nerve|ciliary nerve|ophthalmic nerve [Va]|ophthalmic nerve [V1]|trigeminal nerve ophthalmic division|ophthalmic division [Va]|ophthalmic division [V1]|trigeminal V nerve ophthalmic division|ophthalmic division|ramus opthalmicus profundus (ramus V1)|first branch of fifth cranial nerve|ethmoidal nerve|profundus nerve|cranial nerve V, branch V1|nervus ophthalmicus [va]|nervus ophthalmicus [v1]|rostral branch of trigeminal nerve|ophthalmic division of fifth cranial nerve|first division of trigeminal nerve|ophthalmic division of trigeminal nerve (Va)|opthalmic nerve|first division of fifth cranial nerve|ophthalmic division of trigeminal nerve (V1)|nervus ophthalmicus (V1)|nervus ophthalmicus (Va)|ophthalmic division|profundus	http://purl.obolibrary.org/obo/UBERON_0000348		human_reference_atlas|pheno_slim
HP:0020137	biolink:PhenotypicFeature	Anticardiolipin IgM antibody positivity	The presence of circulating IgM autoantibodies to cardiolipin.		hp.json		http://purl.obolibrary.org/obo/HP_0020137		
UBERON:0000349	biolink:AnatomicalEntity	limbic system	A set of midline structures surrounding the brainstem of the mammalian brain, originally described anatomically, e.g., hippocampal formation, amygdala, hypothalamus, cingulate cortex. Although the original designation was anatomical, the limbic system has come to be associated with the system in the brain subserving emotional functions. As such, it is very poorly defined and doesn't correspond closely to the anatomical meaning any longer. [BirnLex].	GAID:615|UMLS:C0023715|BTO:0000928|FMA:242000|NCIT:C94541|MESH:D008032|OpenCyc:Mx4rwAeba5wpEbGdrcN5Y29ycA|CALOHA:TS-1307	hp.json	visceral brain	http://purl.obolibrary.org/obo/UBERON_0000349		non_informative|pheno_slim
HP:0020139	biolink:PhenotypicFeature	History of recent insect bite	Medical history of a recent bite injury due to an insect.		hp.json		http://purl.obolibrary.org/obo/HP_0020139		
UBERON:0012332	biolink:AnatomicalEntity	broad ligament of uterus	A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis.	NCIT:C12318|MESH:D001956|FMA:16516|UMLS:C0006205	hp.json	ligamentum latum uteri|broad uterine ligament|broad ligament	http://purl.obolibrary.org/obo/UBERON_0012332		human_reference_atlas
HP:0032101	biolink:PhenotypicFeature	Unusual infection	A type of infection that is regarded as a sign of a pathological susceptibility to infection. There are five general subtypes. (i) Opportunistic infection, meaning infection by a pathogen that is not normally able to cause infection in a healthy host (e.g., pneumonia by Pneumocystis jirovecii or CMV); (ii) Unusual location (focus) of an infection (e.g., an aspergillus brain abscess); (iii) a protracted course or lack of adequate response to treatment (e.g., chronic rhinosinusitis); (iv) Unusual severity or intensity of an infection; and (v) unusual recurrence of infections.		hp.json		http://purl.obolibrary.org/obo/HP_0032101		
HP:0032102	biolink:PhenotypicFeature	Wilson sign	Wilson sign is defined as the elicitation of pain by internally rotating the patient's tibia during knee extension between 90 degrees and 30 degrees of flexion and then relieving that pain by externally rotating the tibia.		hp.json		http://purl.obolibrary.org/obo/HP_0032102		
UBERON:0012330	biolink:AnatomicalEntity	nasal-associated lymphoid tissue	The lymphocytic cell population present in the mucosa of the nasopharyngeal duct of some animals.	NCIT:C77659|FMA:79771|UMLS:C2698431|MA:0003030	hp.json	NALT|naso-pharyngeal lymphoid tissue	http://purl.obolibrary.org/obo/UBERON_0012330		
HP:0032104	biolink:PhenotypicFeature	Saccadic oscillation	An involuntary abnormality of fixation in which there is an abnormal saccade away from fixation followed by an immediate corrective saccade.		hp.json	Saccadic oscillations	http://purl.obolibrary.org/obo/HP_0032104		
HP:0032100	biolink:PhenotypicFeature	Abnormal doll's eye reflex	The doll's eye reflex (also known as oculocephalic reflex) is a test of brain function that is performed in comatose patients by elevating the head roughly 30 degrees and rapidly rotating the head from side to side with the eyes kept open. A normal response is for the eyes to move in the opposite direction. If the eyes do not move in the opposite direction this may indicate severe brain damage.		hp.json		http://purl.obolibrary.org/obo/HP_0032100		
UBERON:0012329	biolink:AnatomicalEntity	keratinized stratified squamous epithelium	Keratinized stratified squamous epithelium is a stratified squamous epithelium, the cells of which synthesize and accumulate keratin.	FMA:45568	hp.json	epithelium stratificatum squamosum cornificatum	http://purl.obolibrary.org/obo/UBERON_0012329		
HP:0032109	biolink:PhenotypicFeature	Moderately reduced contrast sensitivity	A moderate reduction in the ability to perceive visual contrast characterized by 0.60-0.99 log unit contrast sensitivity loss.		hp.json	Moderate reduction in contrast sensitivity	http://purl.obolibrary.org/obo/HP_0032109		
HP:0032105	biolink:PhenotypicFeature	Macrosaccadic oscillations	A type of saccadic oscillations with brief periods of fixation between saccades (intersaccadic interval approximately 200 msec). Macrosaccadic oscillations (up to 40 degrees) straddle the intended fixation position and show a crescendo-decrescendo pattern.		hp.json	Macrosaccadic oscillation	http://purl.obolibrary.org/obo/HP_0032105		
HP:0032106	biolink:PhenotypicFeature	Conjunctival icterus	Conjunctival icterus is a condition where there is yellowing of the whites of the eyes. This is most commonly seen in patients who have liver disease.		hp.json	Yellowing of the whites of the eyes|Scleral icterus|Yellow conjunctiva|Yellow sclera	http://purl.obolibrary.org/obo/HP_0032106		
HP:0032107	biolink:PhenotypicFeature	Limbal stem cell deficiency	A condition characterized by a loss or deficiency of the stem cells in the limbus that are vital for re-population of the corneal epithelium and to the barrier function of the limbus.		hp.json		http://purl.obolibrary.org/obo/HP_0032107		
HP:0032108	biolink:PhenotypicFeature	Mildly reduced contrast sensitivity	A mild reduction in the ability to perceive visual contrast characterized by 0.20-0.59 log unit contrast sensitivity loss.		hp.json	Mild reduction in contrast sensitivity	http://purl.obolibrary.org/obo/HP_0032108		
HP:0007178	biolink:PhenotypicFeature	Motor polyneuropathy		SNOMEDCT_US:95663000|UMLS:C0271683|UMLS:C0235025|MSH:D009443|SNOMEDCT_US:85423005|MSH:D011115	hp.json	Peripheral motor neuropathy	http://purl.obolibrary.org/obo/HP_0007178		
HP:0020134	biolink:PhenotypicFeature	Increased urine neutrophil count	Abnormally increased count of neutrophils in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020134		
HP:0007179	biolink:PhenotypicFeature	Absent smooth pursuit	A complete lack of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion.	UMLS:C4024928	hp.json		http://purl.obolibrary.org/obo/HP_0007179		
UBERON:0000355	biolink:AnatomicalEntity	pharyngeal mucosa	A mucosa that is part of a pharynx [Automatically generated definition].	FMA:55031|SCTID:362121003|MA:0003143|EMAPA:26957|BTO:0001047	hp.json	mucous membrane of pharynx|organ mucosa of pharynx|pharynx mucosa of organ|mucous membrane of pharynx|mucosa of pharynx|mucosa of organ of pharynx|pharynx mucous membrane|tunica mucosa pharyngis|mucous membrane of the pharynx|pharynx mucosa|pharynx organ mucosa|tunica mucosa pharyngea	http://purl.obolibrary.org/obo/UBERON_0000355		
HP:0020133	biolink:PhenotypicFeature	Podocyte hypertrophy	Increased visceral epithelial cell size, with or without cytoplasmic protein droplets.		hp.json	Hypertrophy of visceral epithelial cells|Glomerular visceral epithelial cell hypertrophy	http://purl.obolibrary.org/obo/HP_0020133		
HP:0020136	biolink:PhenotypicFeature	Anticardiolipin IgG antibody positivity	The presence of circulating IgG autoantibodies to cardiolipin.		hp.json		http://purl.obolibrary.org/obo/HP_0020136		
HP:0020135	biolink:PhenotypicFeature	Myofibromatosis	A mesenchymal neoplasm characterized by solitary or multiple nodules involving the skin, striated muscles, bones and, sometimes, viscera. It usually appears as a subcutaneous nodule, but can also appear as an ulcer, pedunculated lesion, or similar to a hemangioma. Histology shows well-circumscribed tapered cell lobes, resembling smooth muscle cells. At its center, perivascular round cells (hemangiopericitoides) are usually observed, giving a biphasic appearance.		hp.json		http://purl.obolibrary.org/obo/HP_0020135		
HP:0020130	biolink:PhenotypicFeature	Increased urinary neutrophil gelatinase-associated lipocalin	An increased concentration of neutrophil gelatinase-associated lipocalin in the urine (there is no generally accepted threshold, but some studies choose a threshold of above 150 nanogram per milliliter).		hp.json	Increased urinary NGAL	http://purl.obolibrary.org/obo/HP_0020130		
UBERON:0000351	biolink:AnatomicalEntity	nuchal ligament	A fibrous membrane, which, in the neck, represents the supraspinal ligaments of the upper vertebrae.	BTO:0000952|FMA:13427|EMAPA:19207	hp.json	paxwax|paddywhack|ligament of neck|ligamentum nuchae	http://purl.obolibrary.org/obo/UBERON_0000351		
HP:0020132	biolink:PhenotypicFeature	Thickening of the tubular basement membrane	Increase in thickness of the basement membrane of the tubulus of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0020132		
UBERON:0000353	biolink:AnatomicalEntity	parenchyma	Functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues.	Wikipedia:Parenchyma|NCIT:C74601|EHDAA:6903|EHDAA:8086|EHDAA:3999|EHDAA:9196|EHDAA:9182|EHDAA:6899|EHDAA:4005|EHDAA:3015|EHDAA:9190|EHDAA:6994|UMLS:C0933845|FMA:45732|EHDAA:9202|EHDAA:3905	hp.json		http://purl.obolibrary.org/obo/UBERON_0000353		
HP:0020131	biolink:PhenotypicFeature	Abnormal tubular basement membrane morphology	Abnormal structure of the basement membrane of the renal tubulus.		hp.json		http://purl.obolibrary.org/obo/HP_0020131		
UBERON:0002916	biolink:AnatomicalEntity	central sulcus	The central sulcus is a fold in the cerebral cortex of brains in vertebrates. Also called the central fissure, it was originally called the fissure of Rolando or the Rolandic fissure, after Luigi Rolando. The central sulcus is a prominent landmark of the brain, separating the parietal lobe from the frontal lobe and the primary motor cortex from the primary somatosensory cortex. [WP,unvetted].	DHBA:10614|NCIT:C32280|HBA:9403|UMLS:C1281071|BIRNLEX:4035|OpenCyc:Mx4rvjMKxpwpEbGdrcN5Y29ycA|FMA:83752|UMLS:C0228188|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=48|BM:Tel-Cx-CS|UMLS:C0228188|BAMS:cs	hp.json	central cerebral sulcus|central fissure|sulcus centralis cerebri|rolandic fissure|sulcus centralis|sulcus centralis (rolandi)|CS|central sulcus of Rolando|sulcus centralis cerebri|fissure of Rolando|sulcus of Rolando	http://purl.obolibrary.org/obo/UBERON_0002916		uberon_slim
HP:0010720	biolink:PhenotypicFeature	Abnormal hair pattern	An abnormality of the distribution of hair growth.	UMLS:C4023721	hp.json	Abnormal hair pattern|Abnormal distribution of hair	http://purl.obolibrary.org/obo/HP_0010720		
UBERON:8470000	biolink:AnatomicalEntity	placental blood	Blood located in the placenta.		hp.json		http://purl.obolibrary.org/obo/UBERON_8470000		
HP:0009728	biolink:PhenotypicFeature	Neoplasm of striated muscle	A benign or malignant neoplasm (tumour) originating in striated muscle, either skeletal muscle or cardiac muscle.	UMLS:C4021396|NCIT:C3262	hp.json	Tumours of striated muscle|Tumors of striated muscle	http://purl.obolibrary.org/obo/HP_0009728		
HP:0010728	biolink:PhenotypicFeature	Aplasia of the retina	A developmental defect characterized by absence of the retina.	UMLS:C4023718	hp.json	Absent retina	http://purl.obolibrary.org/obo/HP_0010728		
HP:0010727	biolink:PhenotypicFeature	Spontaneous rupture of the globe	Rupture of the eyeball not due to trauma.	UMLS:C4023719	hp.json		http://purl.obolibrary.org/obo/HP_0010727		hposlim_core
HP:0009727	biolink:PhenotypicFeature	Achromatic retinal patches	Areas of the retina lacking pigmentation. Punched out areas of chorioretinal hypopigmentation less than 1 disc diameter in size and tending to be located in the midperiphery of the retina.	UMLS:C1860710	hp.json	Punched out areas of chorioretinal hypopigmentation	http://purl.obolibrary.org/obo/HP_0009727		
HP:0010726	biolink:PhenotypicFeature	Prominent corneal nerve fibers	Abnormal prominence of the corneal nerve fibers.	UMLS:C4021233	hp.json	Prominent corneal nerve fibres|Visible corneal nerve fibers|Visible corneal nerve fibres	http://purl.obolibrary.org/obo/HP_0010726		
HP:0009729	biolink:PhenotypicFeature	Cardiac rhabdomyoma	A benign tumor of cardiac striated muscle.	UMLS:C1332852	hp.json		http://purl.obolibrary.org/obo/HP_0009729		
HP:0009724	biolink:PhenotypicFeature	Subungual fibromas	The presence of fibromata beneath finger or toenails.	SNOMEDCT_US:39295002|UMLS:C0266003	hp.json	Subungual fibroma	http://purl.obolibrary.org/obo/HP_0009724		
HP:0010724	biolink:PhenotypicFeature	Advanced pneumatization of the mastoid process	An abnormally advanced degree of pneumatization (i.e., formation of air cells) in the mastoid process with respect to age-dependent norms.	UMLS:C4021828	hp.json		http://purl.obolibrary.org/obo/HP_0010724		hposlim_core
HP:0009723	biolink:PhenotypicFeature	Abnormality of the subungual region	A lesion located beneath a fingernail or toenail.	UMLS:C4024219	hp.json		http://purl.obolibrary.org/obo/HP_0009723		
HP:0010723	biolink:PhenotypicFeature	Cystic lesions of the pinnae		UMLS:C4023720	hp.json		http://purl.obolibrary.org/obo/HP_0010723		
HP:0009726	biolink:PhenotypicFeature	Renal neoplasm	The presence of a neoplasm of the kidney.	SNOMEDCT_US:126880001|UMLS:C1378703|UMLS:C0022665|NCIT:C3262|MSH:D007680	hp.json	Neoplasia of the kidneys|Renal neoplasia|Kidney cancer|Renal tumours|Renal tumors	http://purl.obolibrary.org/obo/HP_0009726		
HP:0010722	biolink:PhenotypicFeature	Asymmetry of the ears	An asymmetriy, i.e., difference in size, shape or position between the left and right ear.	UMLS:C1168239	hp.json	Asymmetric ears	http://purl.obolibrary.org/obo/HP_0010722		hposlim_core
HP:0009725	biolink:PhenotypicFeature	Bladder neoplasm	The presence of a neoplasm of the urinary bladder.	SNOMEDCT_US:126885006|MSH:D001749|UMLS:C0005695|NCIT:C3262	hp.json	Bladder tumor|Bladder cancer|Bladder tumour	http://purl.obolibrary.org/obo/HP_0009725		
HP:0010721	biolink:PhenotypicFeature	Abnormal hair whorl	An abnormal hair whorl (that is, a patch of hair growing in the opposite direction of the rest of the hair).	UMLS:C3280303	hp.json	Abnormal hair whorl|Abnormal hair whorls|Abnormal whorl of hair	http://purl.obolibrary.org/obo/HP_0010721		
HP:0009720	biolink:PhenotypicFeature	Adenoma sebaceum	The presence of a sebaceous adenoma with origin in the sebum secreting cells of the skin.	MSH:D014402|SNOMEDCT_US:36025004|SNOMEDCT_US:78424008|UMLS:C0265319|UMLS:C1368816	hp.json	Sebaceous adenoma|Facial angiofibromas|Sebaceous adenomas	http://purl.obolibrary.org/obo/HP_0009720		
CHEBI:37395	biolink:ChemicalSubstance	mucopolysaccharide	Any of the group of polysaccharides composed of alternating units from uronic acids and glycosamines, and commonly partially esterified with sulfuric acid.	KEGG:C05114	hp.json	Mukopolysaccharid|mucopolisacarido|Mucopolysaccharide|mucopolisacaridos|mucopolysaccharides|Mucopolysaccharid	http://purl.obolibrary.org/obo/CHEBI_37395		3_STAR
CHEBI:144637	biolink:ChemicalSubstance	4-hydroxy-D-proline	The D-stereoisomer of 4-hydroxyproline.		hp.json	4-hydroxy-D-Pro|4-OH-D-Pro|4-hydroxy-D-proline|(2R)-4-hydroxypyrrolidine-2-carboxylic acid	http://purl.obolibrary.org/obo/CHEBI_144637		3_STAR
HP:0009722	biolink:PhenotypicFeature	Dental enamel pits	The presence of small depressions in the dental enamel.	UMLS:C1860711	hp.json	Pitting of tooth enamel|Tooth enamel pits|Dental enamel pits|Dental enamel pitting	http://purl.obolibrary.org/obo/HP_0009722		
HP:0009721	biolink:PhenotypicFeature	Shagreen patch	A plaque representing a connective-tissue nevus. Connective tissue naevi are uncommon skin lesions that occur when the deeper layers of the skin do not develop correctly or the components of these layers occur in the wrong proportion. Shagreen patches are oval-shaped and nevoid, skin-colored or occasionally pigmented, smooth or crinkled. The word shagreen refers to a type of roughened untanned leather.	SNOMEDCT_US:254244007|UMLS:C0432363	hp.json		http://purl.obolibrary.org/obo/HP_0009721		hposlim_core
CHEBI:37397	biolink:ChemicalSubstance	chondroitin sulfate	Any of a class of 10--60 kDa glycosaminoglycan sulfates, widely distributed in cartilage and other mammalian connective tissues.	PMID:7538297|PMID:11514091|KEGG:C00607|CAS:9007-28-7|CAS:9007-28-7	hp.json	Chondroitin sulfate|Chondroitinsulfat|chondroitin sulfuric acid|chondroitin polysulfate|chondroitin sulphate|chondroitin sulfates	http://purl.obolibrary.org/obo/CHEBI_37397		3_STAR
HP:0010729	biolink:PhenotypicFeature	Cherry red spot of the macula	Pallor of the perifoveal macula of the retina with appearance of a small circular reddish choroid shape as seen through the fovea centralis due to relative transparancy of the macula.	UMLS:C2216370	hp.json	Macular cherry red spot	http://purl.obolibrary.org/obo/HP_0010729		
GO:0035418	biolink:BiologicalProcess	protein localization to synapse	Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.		hp.json	protein localisation to synapse	http://purl.obolibrary.org/obo/GO_0035418		
HP:0010717	biolink:PhenotypicFeature	Osseous syndactyly of toes	Webbing or fusion of the toes, involving soft parts and including fusion of individual bones of the toes. Bony fusions are referred to as "bony" Syndactyly if the fusion occurs in a tibial-fibular axis. Fusions of bones of the toes in a proximo-distal axis are referred to as "Symphalangism".	SNOMEDCT_US:38859008|SNOMEDCT_US:32113001|UMLS:C0158738	hp.json	Osseous syndactyly of the toes	http://purl.obolibrary.org/obo/HP_0010717		hposlim_core
HP:0009739	biolink:PhenotypicFeature	Hypoplasia of the antihelix	Developmental hypoplasia of the antihelix.	UMLS:C4021394	hp.json	Hypoplastic antihelix	http://purl.obolibrary.org/obo/HP_0009739		
HP:0009738	biolink:PhenotypicFeature	Abnormal antihelix morphology	An abnormality of the antihelix.	UMLS:C4021395	hp.json	Abnormal anthelix|Abnormal antehelix|Abnormal antihelix	http://purl.obolibrary.org/obo/HP_0009738		hposlim_core
HP:0010716	biolink:PhenotypicFeature	3-5 toe syndactyly	Syndactyly with fusion of toes three to five.	UMLS:C4023723	hp.json	Webbed 3rd-5th toes	http://purl.obolibrary.org/obo/HP_0010716		
HP:0010715	biolink:PhenotypicFeature	2-5 toe syndactyly	Syndactyly with fusion of toes two to five.	UMLS:C4023724	hp.json	Webbed 2nd-5th toes	http://purl.obolibrary.org/obo/HP_0010715		
HP:0010714	biolink:PhenotypicFeature	2-4 toe syndactyly	Syndactyly with fusion of toes two to four.	UMLS:C4021234	hp.json	Syndactyly of toes 2, 3 and 4|Syndactyly toes 2-4|Webbed 2nd-4th toes	http://purl.obolibrary.org/obo/HP_0010714		
HP:0009735	biolink:PhenotypicFeature	Spinal neurofibromas	Neurofibromas originating in the spine.	UMLS:C4024217	hp.json		http://purl.obolibrary.org/obo/HP_0009735		
HP:0010713	biolink:PhenotypicFeature	1-5 toe syndactyly	Syndactyly with fusion of toes one to five (complete syndactyly of all toes of the foot).	UMLS:C4021235	hp.json	Webbed 1st-5th toes|Syndactyly of all toes	http://purl.obolibrary.org/obo/HP_0010713		
HP:0010712	biolink:PhenotypicFeature	1-4 toe syndactyly	Syndactyly with fusion of toes one to four.	UMLS:C4023725	hp.json	Webbed first through fourth toes	http://purl.obolibrary.org/obo/HP_0010712		
HP:0009734	biolink:PhenotypicFeature	Optic nerve glioma	A glioma originating in the optic nerve or optic chiasm.	UMLS:C0346326|SNOMEDCT_US:254976006|MSH:D020339|SNOMEDCT_US:404662003	hp.json	Optic glioma	http://purl.obolibrary.org/obo/HP_0009734		
HP:0009737	biolink:PhenotypicFeature	Lisch nodules	The presence of pigmented, oval and dome-shaped raised hamartomatous nevi of the iris..	UMLS:C1860334	hp.json	Iris hamartomas	http://purl.obolibrary.org/obo/HP_0009737		hposlim_core
HP:0010711	biolink:PhenotypicFeature	1-2 toe syndactyly	Syndactyly with fusion of toes one and two.	UMLS:C4023726	hp.json	Webbed first and second toes|Webbed 1st-2nd toes	http://purl.obolibrary.org/obo/HP_0010711		
HP:0009736	biolink:PhenotypicFeature	Tibial pseudarthrosis	Pseudarthrosis, or "false joint" of the tibia is the result of a developmental failure in the tibia progressing to spontaneous fracture and subsequent fibrous nonunion. The fracture is rarely present at birth but commonly develops during the first 18 months of life.	UMLS:C4024216	hp.json	Tibial pseudoarthrosis	http://purl.obolibrary.org/obo/HP_0009736		
HP:0010710	biolink:PhenotypicFeature	3-5 finger syndactyly	Syndactyly with fusion of fingers three to five.	UMLS:C4023727	hp.json	Webbed third, fourth and fifth toes	http://purl.obolibrary.org/obo/HP_0010710		
HP:0009731	biolink:PhenotypicFeature	Cerebral hamartoma	The presence of a hamartoma of the cerebrum.	UMLS:C4024218	hp.json	Cerebral hamartomata	http://purl.obolibrary.org/obo/HP_0009731		
HP:0009730	biolink:PhenotypicFeature	Rhabdomyoma	A benign tumor of striated muscle.	SNOMEDCT_US:302846007|NCIT:C3358|UMLS:C0035411|SNOMEDCT_US:43375002|MSH:D012207|SNOMEDCT_US:402877008	hp.json		http://purl.obolibrary.org/obo/HP_0009730		
HP:0009733	biolink:PhenotypicFeature	Glioma	The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes).	MSH:D005910|UMLS:C0017638|NCIT:C3059|SNOMEDCT_US:115240006|SNOMEDCT_US:74532006|SNOMEDCT_US:393564001	hp.json		http://purl.obolibrary.org/obo/HP_0009733		
HP:0009732	biolink:PhenotypicFeature	Plexiform neurofibroma	A neurofibroma in which Schwann cells proliferate inside the nerve sheath, producing an irregularly thickened, distorted, tortuous structure.	UMLS:C0206728|SNOMEDCT_US:41252002|SNOMEDCT_US:403818001|MSH:D018318	hp.json		http://purl.obolibrary.org/obo/HP_0009732		
HP:0010719	biolink:PhenotypicFeature	Abnormality of hair texture	An abnormality of the texture of the hair.	UMLS:C4073290|UMLS:C4072881|UMLS:C4023722|UMLS:C4072880	hp.json	Abnormality of hair curl pattern|Abnormality of hair volume|Abnormality of hair consistency|Abnormality of hair texture	http://purl.obolibrary.org/obo/HP_0010719		
HP:0009709	biolink:PhenotypicFeature	Increased CSF interferon alpha	Increased concentration of interferon alpha in the cerebrospinal fluid (CSF).	UMLS:C1856983	hp.json		http://purl.obolibrary.org/obo/HP_0009709		
HP:0010706	biolink:PhenotypicFeature	1-3 finger syndactyly	Syndactyly with fusion of fingers one to three.	UMLS:C4023730	hp.json	Webbed 1st-3rd finger	http://purl.obolibrary.org/obo/HP_0010706		
HP:0009706	biolink:PhenotypicFeature	Synostosis involving the 3rd metacarpal		UMLS:C4024227	hp.json	Fusion involving the 3rd long bone of hand	http://purl.obolibrary.org/obo/HP_0009706		
HP:0010705	biolink:PhenotypicFeature	4-5 finger syndactyly	Syndactyly with fusion of fingers four and five.	UMLS:C4023731	hp.json	Webbed 4th-5th finger	http://purl.obolibrary.org/obo/HP_0010705		
HP:0009705	biolink:PhenotypicFeature	Synostosis involving the 2nd metacarpal		UMLS:C4024228	hp.json	Fusion involving the 2nd long bone of hand	http://purl.obolibrary.org/obo/HP_0009705		
HP:0010704	biolink:PhenotypicFeature	1-2 finger syndactyly	Syndactyly with fusion of fingers one and two.	UMLS:C4023732	hp.json	Webbed 1st-2nd finger|Webbed thumb and index finger	http://purl.obolibrary.org/obo/HP_0010704		
HP:0009708	biolink:PhenotypicFeature	Synostosis involving the 5th metacarpal		UMLS:C4024225	hp.json	Fusion involving the 5th long bone of hand	http://purl.obolibrary.org/obo/HP_0009708		
HP:0009707	biolink:PhenotypicFeature	Synostosis involving the 4th metacarpal		UMLS:C4024226	hp.json	Fusion involving the 4th long bone of hand	http://purl.obolibrary.org/obo/HP_0009707		
HP:0010702	biolink:PhenotypicFeature	Increased circulating antibody level	An increased level of gamma globulin (immunoglobulin) in the blood.	MSH:D006942|UMLS:C0541985|SNOMEDCT_US:129646001|UMLS:C1306857|SNOMEDCT_US:127388009|UMLS:C2048011|UMLS:C0151669|UMLS:C0020455	hp.json	Increased gamma globulin|Increased antibody level in blood|Elevated immunoglobulin levels|Raised immunoglobulin levels|Increased serum gamma globulin|Increased immunoglobulin level|Hypergammaglobulinaemia|Hyperglobulinemia|Hypergammaglobulinemia	http://purl.obolibrary.org/obo/HP_0010702		
HP:0009702	biolink:PhenotypicFeature	Carpal synostosis	Synostosis (bony fusion) involving one or more bones of the carpus (scaphoid, lunate, triquetrum, trapezium, trapezoid, capitate, hamate, pisiform).	UMLS:C0431863|SNOMEDCT_US:253930002	hp.json	Synostosis involving the carpal bones|Fusion of carpal bones|Fused carpal bones|Fused wrist bones|Carpal fusion|Carpal bone fusion	http://purl.obolibrary.org/obo/HP_0009702		hposlim_core
HP:0010701	biolink:PhenotypicFeature	Abnormal immunoglobulin level	An abnormal deviation from normal levels of immunoglobulins in blood.	UMLS:C1855755	hp.json	Abnormal serum immunoglobulin levels|Abnormal serum immunoglobulin concentration|Abnormal serum level of immunoglobulin|Immunoglobulin abnormality|Abnormal immunoglobulin concentration	http://purl.obolibrary.org/obo/HP_0010701		
HP:0009701	biolink:PhenotypicFeature	Metacarpal synostosis	Fusion involving two or more metacarpal bones (A synostosis of the first metacarpal and the proximal phalanx of the thumb can also be observed, note that the first metacarpal bone corresponds to a proximal phalanx).	UMLS:C4021398	hp.json	Synostosis involving metacarpal bones|Fused long bones of hand|Synostosis involving the metacarpal bones	http://purl.obolibrary.org/obo/HP_0009701		hposlim_core
HP:0009704	biolink:PhenotypicFeature	Chronic CSF lymphocytosis	Chronic cerebrospinal fluid (CSF) lymphocytosis is defined as the finding, in at least two serial CSF examinations, of more than 5 cells per cubic millimeter.	UMLS:C4024229	hp.json	Chronic cerebrospinal fluid lymphocytosis	http://purl.obolibrary.org/obo/HP_0009704		
HP:0010700	biolink:PhenotypicFeature	obsolete Total cataract			hp.json		http://purl.obolibrary.org/obo/HP_0010700		
HP:0009703	biolink:PhenotypicFeature	Synostosis involving the 1st metacarpal	Fusion of the 1st metacarpal with another bone. In contrast to the proximal phalanges of the digits 2 to 5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4021397	hp.json	First metacarpophalangeal joint synostosis|Fusion involving 1st long bone of hand|Symphalangism affecting the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0009703		
HP:0009700	biolink:PhenotypicFeature	Finger symphalangism	An abnormal union between bones or parts of bones of the fingers. The synonymous term "symphalangism of the hand" may be translated as fusions of bones of varying digree, that involve at least one phalangeal bone of the hand. If bony fusions are referred to as "Symphalangism" the fusion occurs in a proximo-distal axis. Fusions of bones of the fingers in a radio-ulnar axis are referred to as "bony" Syndactyly.	UMLS:C4021399	hp.json	Synostosis involving bones of the fingers|Fused finger bones|Symphalangism of the hand	http://purl.obolibrary.org/obo/HP_0009700		
HP:0010709	biolink:PhenotypicFeature	2-4 finger syndactyly	Syndactyly with fusion of the fingers two to four.	UMLS:C4021236	hp.json	Webbed index through ring fingers|Syndactyly of second to fourth fingers	http://purl.obolibrary.org/obo/HP_0010709		
HP:0010708	biolink:PhenotypicFeature	1-5 finger syndactyly	Syndactyly with fusion of fingers one to five (complete syndactyly of all fingers of the hand).	UMLS:C4023728	hp.json	Webbed 1-5 fingers|Webbed 1st-5th fingers	http://purl.obolibrary.org/obo/HP_0010708		
HP:0010707	biolink:PhenotypicFeature	1-4 finger syndactyly	Syndactyly with fusion of fingers one to four.	UMLS:C4023729	hp.json	Webbed 1st-4th finger	http://purl.obolibrary.org/obo/HP_0010707		
HP:0009717	biolink:PhenotypicFeature	Cortical tubers	Cortical tubers in the brain are hamartomatous lesions typically located at the gray-white matter interface, commonly in the frontal and parietal lobes. Cortical tubers are composed of abnormal glial and neural cells, and the size, number, and location vary among patients.	UMLS:C1968959	hp.json		http://purl.obolibrary.org/obo/HP_0009717		
HP:0009716	biolink:PhenotypicFeature	Subependymal nodules	Small nodular masses which originate in the subependymal region of the lateral ventricles and protrude into the ventricular cavity. They may represent subependymal hamartomas of tuberous sclerosis.	UMLS:C1968958	hp.json		http://purl.obolibrary.org/obo/HP_0009716		
HP:0009719	biolink:PhenotypicFeature	Hypomelanotic macule	Hypomelanotic macules ("ash leaf spots") are white or lighter patches of skin that may appear anywhere on the body and are caused by a lack of melanin. White ash leaf-shaped macules are considered to be characteristic of tuberous sclerosis.	UMLS:C4024220	hp.json	Hypomelanotic macules	http://purl.obolibrary.org/obo/HP_0009719		
HP:0009718	biolink:PhenotypicFeature	Subependymal giant-cell astrocytoma	A demarcated, largely intraventricular tumor in the region of the foramen of Monro composed of spindle to large plump or ganglion-like cells with eosinophilic to amphophilic cytoplasm and somewhat pleomorphic nuclei with occasional prominent nucleoli. These tumors are almost always associated with tuberous sclerosis.	SNOMEDCT_US:449799008|MSH:D001254|SNOMEDCT_US:1586004|UMLS:C0205768	hp.json		http://purl.obolibrary.org/obo/HP_0009718		
HP:0009713	biolink:PhenotypicFeature	Spinal hemangioblastoma	A hemangioblastoma of the spinal cord.	NCIT:C3801|UMLS:C4024223	hp.json		http://purl.obolibrary.org/obo/HP_0009713		
HP:0009715	biolink:PhenotypicFeature	Papillary cystadenoma of the epididymis	A cystadenoma, an epithelial tumor, that originates within the head of the epididymis.	NCIT:C2974|UMLS:C4024221	hp.json		http://purl.obolibrary.org/obo/HP_0009715		
HP:0009714	biolink:PhenotypicFeature	Abnormal epididymis morphology	An abnormality of the epididymis.	UMLS:C4024222	hp.json	Abnormality of the epididymis	http://purl.obolibrary.org/obo/HP_0009714		
HP:0009711	biolink:PhenotypicFeature	Retinal capillary hemangioma	A benign vascular tumor of the retina without any neoplastic characteristics.	NCIT:C3801|UMLS:C1514915|UMLS:C0730303|SNOMEDCT_US:312935003	hp.json	Retinal hemangioblastoma	http://purl.obolibrary.org/obo/HP_0009711		hposlim_core
HP:0009710	biolink:PhenotypicFeature	Chilblains	Chilblains, also called perniosis, are an inflammatory skin condition related to an abnormal vascular response to the cold. We are unaware of a reliable estimate of incidence. It typically presents as tender, pruritic red or bluish lesions located symmetrically on the dorsal aspect of the fingers, toes, ears and nose. Less commonly, reports describe involvement of the thighs and buttocks. The lesions present hours after exposure to cold and usually resolve spontaneously in one to three weeks.	UMLS:C4024224	hp.json	Chilblain lesions	http://purl.obolibrary.org/obo/HP_0009710		
CHEBI:50341	biolink:ChemicalSubstance	1-hydroxyethyl group			hp.json	1-hydroxyethyl|threonine side-chain	http://purl.obolibrary.org/obo/CHEBI_50341		3_STAR
CHEBI:50340	biolink:ChemicalSubstance	3-carbamimidamidopropyl group			hp.json	3-(carbamimidoylamino)propyl|3-carbamimidamidopropyl|arginine side-chain|3-guanidinopropyl	http://purl.obolibrary.org/obo/CHEBI_50340		3_STAR
CHEBI:50336	biolink:ChemicalSubstance	4-hydroxybenzyl group			hp.json	tyrosine side-chain|4-hydroxybenzyl	http://purl.obolibrary.org/obo/CHEBI_50336		3_STAR
CHEBI:50339	biolink:ChemicalSubstance	4-aminobutyl group			hp.json	4-aminobutyl|lysine side-chain	http://purl.obolibrary.org/obo/CHEBI_50339		3_STAR
CHEBI:50338	biolink:ChemicalSubstance	1H-imidazol-4-ylmethyl group			hp.json	1H-imidazol-4-ylmethyl|histidine side-chain	http://purl.obolibrary.org/obo/CHEBI_50338		3_STAR
UBERON:0002956	biolink:AnatomicalEntity	granular layer of cerebellar cortex	The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.	BIRNLEX:779|NCIT:C49138|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=363|EMAPA:35217|BTO:0004425|CALOHA:TS-1247|FMA:83140|UMLS:C1708253|MA:0000993|MBA:1143	hp.json	cerebellar granular layer|stratum granulosum cerebelli|stratum granulosum corticis cerebelli|granule cell layer of cerebellar cortex|cerebellum granule layer|cerebellar granule cell layer|cerebellum granule cell layer|granular layer of cerebellum|cerebellar granule layer	http://purl.obolibrary.org/obo/UBERON_0002956		pheno_slim
CHEBI:50337	biolink:ChemicalSubstance	1H-indol-3-ylmethyl group			hp.json	tryptophan side-chain|1H-indol-3-ylmethyl	http://purl.obolibrary.org/obo/CHEBI_50337		3_STAR
HP:0010764	biolink:PhenotypicFeature	Short eyelashes	Decreased length of the eyelashes (subjective).	UMLS:C2748682	hp.json	Short eyelashes|Decreased length of eyelashes	http://purl.obolibrary.org/obo/HP_0010764		
HP:0010763	biolink:PhenotypicFeature	Low insertion of columella	Insertion of the posterior columella below the nasal base.	UMLS:C4021229|UMLS:C4280364	hp.json	Columella, low insertion|Ala higher than columella	http://purl.obolibrary.org/obo/HP_0010763		hposlim_core
HP:0010762	biolink:PhenotypicFeature	Chordoma	A chordoma is a tumors that arises from embryonic remnants of the notochord along the length of the neuraxis. Chordomas generally occur in the sacrum, intracranially at the clivus, or along the spinal axis.	SNOMEDCT_US:50007008|MSH:D002817|NCIT:C2947|UMLS:C0008487	hp.json		http://purl.obolibrary.org/obo/HP_0010762		
HP:0010761	biolink:PhenotypicFeature	Broad columella	Increased width of the columella.	UMLS:C1851059|UMLS:C4280365	hp.json	Fullness of columella|Hyperplasia of columella|Increased width of columella|Columella, wide|Columella, broad	http://purl.obolibrary.org/obo/HP_0010761		hposlim_core
HP:0010760	biolink:PhenotypicFeature	Absent toe	Aplasia of a toe. That is, absence of all phalanges of a non-hallux digit of the foot and the associated soft tissues.	UMLS:C3553754	hp.json	Absent toes|Aplasia of toe|Absent toe|Aplasia of the toes	http://purl.obolibrary.org/obo/HP_0010760		hposlim_core
CHEBI:25375	biolink:ChemicalSubstance	monoamine molecular messenger	A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group  (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.		hp.json	monoamines|monamines	http://purl.obolibrary.org/obo/CHEBI_25375		3_STAR
HP:0007109	biolink:PhenotypicFeature	Periventricular cysts		UMLS:C1839858	hp.json		http://purl.obolibrary.org/obo/HP_0007109		
HP:0010769	biolink:PhenotypicFeature	Pilonidal sinus	A sinus in the coccygeal region (the region of the intergluteal cleft). A pilonidal sinus often contains hair and skin debris.	SNOMEDCT_US:47639008|MSH:D010864|UMLS:C0031925	hp.json	Pilonidal cyst	http://purl.obolibrary.org/obo/HP_0010769		hposlim_core
HP:0007105	biolink:PhenotypicFeature	Infantile encephalopathy	Encephalopathy with onset in the infantile period.	UMLS:C1856408	hp.json		http://purl.obolibrary.org/obo/HP_0007105		
HP:0009768	biolink:PhenotypicFeature	Broad phalanges of the hand	Increased width of the phalanges of the hand.	UMLS:C4021391	hp.json	Widening of phalanges of the hand|Wide hand bones	http://purl.obolibrary.org/obo/HP_0009768		
HP:0010767	biolink:PhenotypicFeature	Sacrococcygeal pilonidal abnormality	The presence of a cyst, fistula, or abscess in the sacrococcygeal region (gluteal crease) characteristically accompanied by hair and skin folds.	UMLS:C4023709	hp.json		http://purl.obolibrary.org/obo/HP_0010767		
HP:0009767	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the hand	Small or missing phalangeal bones of the fingers of the hand.	UMLS:C1848670	hp.json	Aplastic/hypoplastic phalanges of the hand|Aplastic/hypoplastic phalanges|Hypoplastic/absent phalanges	http://purl.obolibrary.org/obo/HP_0009767		
HP:0010766	biolink:PhenotypicFeature	Ectopic calcification	Deposition of calcium salts in a tissue or location in which calcification does not normally occur.	UMLS:C3806226	hp.json		http://purl.obolibrary.org/obo/HP_0010766		
HP:0007107	biolink:PhenotypicFeature	Segmental peripheral demyelination	A loss of myelin from the internode regions along myelinated nerve fibers from segments of the peripheral nervous system.	UMLS:C4024938	hp.json		http://purl.obolibrary.org/obo/HP_0007107		
HP:0010765	biolink:PhenotypicFeature	Palmar hyperkeratosis	Abnormal thickening of the skin localized to the palm of the hand.	UMLS:C4023710	hp.json		http://purl.obolibrary.org/obo/HP_0010765		
HP:0009769	biolink:PhenotypicFeature	Bullet-shaped phalanges of the hand	The presence of short and wide phalanges which taper distally ("bullet shaped").	UMLS:C1854952	hp.json	Bullet-shaped hand bones|Bullet-shaped phalanges of the hands|Conical bullet-shaped distal ends of phalanges	http://purl.obolibrary.org/obo/HP_0009769		
HP:0007108	biolink:PhenotypicFeature	Demyelinating peripheral neuropathy	Demyelinating neuropathy is characterized by slow nerve conduction velocities with reduced amplitudes of sensory/motor nerve conduction and prolonged distal latencies.	UMLS:C0270922|SNOMEDCT_US:23414001	hp.json		http://purl.obolibrary.org/obo/HP_0007108		
HP:0009763	biolink:PhenotypicFeature	Limb pain	Chronic pain in the limbs with no clear focal etiology.	UMLS:C0030196|SNOMEDCT_US:90834002	hp.json	Limb pain|Pain in extremities	http://purl.obolibrary.org/obo/HP_0009763		
HP:0007103	biolink:PhenotypicFeature	Hypointensity of cerebral white matter on MRI	A darker than expected signal on magnetic resonance imaging emanating from the cerebral white matter.	UMLS:C4020908	hp.json	White matter hypointensities on MRI	http://purl.obolibrary.org/obo/HP_0007103		
HP:0009765	biolink:PhenotypicFeature	Low hanging columella	Columella extending inferior to the level of the nasal base, when viewed from the side.	UMLS:C1856119|UMLS:C4280395	hp.json	Low-hanging columella|Rounded columella|Prominent columella|Extension of the columella below the ala nasi|Columella extends below the ala nasi|Columella, low hanging|Columella, low	http://purl.obolibrary.org/obo/HP_0009765		
HP:0007104	biolink:PhenotypicFeature	Prolonged somatosensory evoked potentials		UMLS:C4024939	hp.json		http://purl.obolibrary.org/obo/HP_0007104		
HP:0009760	biolink:PhenotypicFeature	Antecubital pterygium	Pterygium affecting the elbow. This is a cutaneous web that can lead to severe flexion contracture of the elbow joint. Antecubital pterygium can be unilateral, bilateral, symmetric, or asysmmetric.	MSH:C566738|UMLS:C1867439	hp.json	Webbed elbow|Pterygium cubitale	http://purl.obolibrary.org/obo/HP_0009760		hposlim_core
CHEBI:50331	biolink:ChemicalSubstance	3-amino-3-oxopropyl group			hp.json	glutamine side-chain|3-amino-3-oxopropyl	http://purl.obolibrary.org/obo/CHEBI_50331		3_STAR
HP:0009762	biolink:PhenotypicFeature	Facial wrinkling	Excessive wrinkling of the skin of the face.	SNOMEDCT_US:248194004|UMLS:C0262478	hp.json	Facial wrinkling	http://purl.obolibrary.org/obo/HP_0009762		
CHEBI:50330	biolink:ChemicalSubstance	2-amino-2-oxoethyl group			hp.json	asparagine side-chain|2-amino-2-oxoethyl	http://purl.obolibrary.org/obo/CHEBI_50330		3_STAR
BSPO:0005001	biolink:NamedThing	intersects midsagittal plane of	X intersects median plane of iff X crosses the midine plane of Y.	BSPO:0005001	hp.json		http://purl.obolibrary.org/obo/BSPO_0005001		
HP:0009761	biolink:PhenotypicFeature	Anterior clefting of vertebral bodies	Anterior schisis (cleft or cleavage) of vertebral bodies.	UMLS:C1849579	hp.json		http://purl.obolibrary.org/obo/HP_0009761		
CHEBI:64909	biolink:ChemicalSubstance	poison	Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism.	Wikipedia:Poison	hp.json	poisonous substances|toxic substances|toxic agent|poisons|poisonous agent|poisonous agents|toxic substance|toxic agents|poisonous substance	http://purl.obolibrary.org/obo/CHEBI_64909		3_STAR
HP:0007100	biolink:PhenotypicFeature	Progressive ventriculomegaly		UMLS:C1865119	hp.json		http://purl.obolibrary.org/obo/HP_0007100		
CHEBI:50325	biolink:ChemicalSubstance	proteinogenic amino-acid side-chain group	A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid.		hp.json	canonical amino-acid side-chain|canonical amino-acid side-chains|proteinogenic amino-acid side-chain|proteinogenic amino-acid side-chain groups|proteinogenic amino-acid side-chains	http://purl.obolibrary.org/obo/CHEBI_50325		3_STAR
HP:0009780	biolink:PhenotypicFeature	Iliac horns	Horn-like malformations of the iliac crests with symmetrical bilateral central posterior iliac processes. A characteristic finding in the Nail-Patella syndrome. Iliac horns are visible on X-ray and may be palpable, but are asymptomatic.	SNOMEDCT_US:84308008|UMLS:C0263925	hp.json		http://purl.obolibrary.org/obo/HP_0009780		
CHEBI:50329	biolink:ChemicalSubstance	2-carboxyethyl group			hp.json	2-carboxyethyl|glutamic acid side-chain	http://purl.obolibrary.org/obo/CHEBI_50329		3_STAR
CHEBI:50326	biolink:ChemicalSubstance	sulfanylmethyl group			hp.json	-CH2-SH|HS-CH2-|sulfanylmethyl|cysteine side-chain	http://purl.obolibrary.org/obo/CHEBI_50326		3_STAR
HP:0010753	biolink:PhenotypicFeature	Midline defect of mandible		UMLS:C4023714	hp.json	Midline cleft of mandible	http://purl.obolibrary.org/obo/HP_0010753		
UBERON:0014930	biolink:AnatomicalEntity	perivascular space	The space between a blood vessel and the pia mater.	NCIT:C83196	hp.json	VRS|Virchow-Robin space|perivascular region|perivascular spaces	http://purl.obolibrary.org/obo/UBERON_0014930		pheno_slim
HP:0010752	biolink:PhenotypicFeature	Cleft mandible	Midline deficiency of the mandible and some or all overlying tissues.	SNOMEDCT_US:92822004|UMLS:C0685786	hp.json	Cleft lower jaw|Mandibular cleft	http://purl.obolibrary.org/obo/HP_0010752		hposlim_core
HP:0010751	biolink:PhenotypicFeature	Dimple chin	A persistent midline depression of the skin over the fat pad of the chin.	UMLS:C1849227	hp.json	Chin skin dimple|Chin dent|Indentation of chin|Gelasin of chin|Dimple chin|Chin butt|Chin dimple|Chin dimples	http://purl.obolibrary.org/obo/HP_0010751		hposlim_core
HP:0010750	biolink:PhenotypicFeature	Dermatochalasis	Loss of elasticity of the upper and lower eyelids causing the skin to sag and bulge.	UMLS:C2674149|SNOMEDCT_US:246815009|UMLS:C0423124	hp.json	Hooding of eyelids|Baggy eyes|Eyelid dermatochalasia|Extra eyelid skin|Redundant eyelid skin|Droopy eyelid skin	http://purl.obolibrary.org/obo/HP_0010750		
CHEBI:25384	biolink:ChemicalSubstance	monocarboxylic acid	An oxoacid containing a single carboxy group.		hp.json	monocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_25384		3_STAR
HP:0010759	biolink:PhenotypicFeature	Prominence of the premaxilla	Prominent positioning of the premaxilla in relation to the rest of the maxilla, the facial skeleton, or mandible. Not necessarily caused by an increase in size (hypertrophy of) the premaxilla.	UMLS:C2749369	hp.json	Prominent premaxilla|Prominence of the intermaxillary bone|Prominence of the primary palate bone|Anterior position of the primary palate bone|Premaxillary bone excess|Anterior position of the premaxilla	http://purl.obolibrary.org/obo/HP_0010759		hposlim_core
HP:0010758	biolink:PhenotypicFeature	Abnormality of the premaxilla	An abnormality of the premaxilla, the most anterior part of the maxilla that usually bears the central and lateral incisors and includes the anterior nasal spine and inferior aspect of the piriform rim. The premaxilla contains the bone and teeth of the primary palate.	UMLS:C4023711	hp.json	Abnormality of the intermaxillary bone|Abnormality of the intermaxillary segment of the maxilla|Abnormality of the premaxillary bone|Abnormality of the primary palate bone	http://purl.obolibrary.org/obo/HP_0010758		
HP:0009779	biolink:PhenotypicFeature	3-4 toe syndactyly	Syndactyly with fusion of toes three and four.	UMLS:C1834062	hp.json	syndactyly of 3rd - 4th toes|Webbed 3rd-4th toes	http://purl.obolibrary.org/obo/HP_0009779		
HP:0010757	biolink:PhenotypicFeature	Aplasia of the premaxilla	Absence of the premaxilla, which is the embryonic structure that forms the anterior part of the maxilla.	UMLS:C4023712	hp.json	Absence of the premaxilla|Failure of development of premaxilla|Absence of the primary palate bone|Absence of the intermaxillary bone|Missing primary palate bone|Missing premaxilla|Aplasia of the primary palate bone|Failure of development of the primary palate bone|Aplasia of the intermaxillary bone	http://purl.obolibrary.org/obo/HP_0010757		
HP:0009778	biolink:PhenotypicFeature	Short thumb	Hypoplasia (congenital reduction in size) of the thumb.	SNOMEDCT_US:253936008|UMLS:C0431890|MSH:C536903	hp.json	Thumb brachydactyly|Short thumb|Short thumbs|Hypoplastic thumb|Thumb hypoplasia|Hypoplastic/small thumb|Hypoplastic thumbs|Small thumbs	http://purl.obolibrary.org/obo/HP_0009778		hposlim_core
HP:0010756	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the premaxilla	Absence or underdevelopment of the premaxilla.	UMLS:C4023713	hp.json	Aplasia/hypoplasia of the primary palate bone|Aplasia/hypoplasia of the intermaxillary bone	http://purl.obolibrary.org/obo/HP_0010756		
HP:0007117	biolink:PhenotypicFeature	Corticospinal tract atrophy		UMLS:C1838868	hp.json		http://purl.obolibrary.org/obo/HP_0007117		
HP:0010755	biolink:PhenotypicFeature	Asymmetry of the maxilla	Asymmetry between the left and right sides of the maxilla.	SNOMEDCT_US:235083001|UMLS:C0399519	hp.json	Unequal sides of maxilla|Tilted upper jaw|Tilted maxilla|Asymmetry of right and left side of the maxilla|Crooked maxilla|Deviation of the upper jaw|Canted upper jaw|Uneven upper jaw|Uneven maxilla|Canted maxilla|Crooked upper jaw|Asymmetry of the upper jaw|Asymmetry of upper jaw|Deviation of the maxilla	http://purl.obolibrary.org/obo/HP_0010755		hposlim_core
HP:0010754	biolink:PhenotypicFeature	Abnormality of the temporomandibular joint	An anomaly of the temporomandibular joint.	SNOMEDCT_US:248401009|UMLS:C0266941|UMLS:C1865318|UMLS:C0424721|SNOMEDCT_US:75630004|UMLS:C4280366	hp.json	Abnormality of the jaw joint|Deformity of the jaw joint|Malformation of jaw joint|Anomaly of the temporomandibular joint|Deformity of the temporomandibular joint|Derangement of the temporomandibular joint|Malformation of the temporomandibular joint	http://purl.obolibrary.org/obo/HP_0010754		
HP:0009775	biolink:PhenotypicFeature	Amniotic constriction ring	Annular constrictions around the digits, limbs, or trunk, occurring congenitally (sometimes causing intrauterine autoamputation) and also associated with a wide variety of disorders. Constrictive amniotic bands are the result of primary amniotic rupture, which can lead to entanglement of fetal tissue (especially limbs) in fibrous amniotic strands.	UMLS:C0334166|UMLS:C1527388|MSH:D000652|SNOMEDCT_US:19988008|MSH:C535821|SNOMEDCT_US:238879003	hp.json	Amniotic constriction band|Pseudoainhum|Congenital constriction band sequence|Amniotic bands	http://purl.obolibrary.org/obo/HP_0009775		
HP:0007112	biolink:PhenotypicFeature	Temporal cortical atrophy	Atrophy of the temporal cortex.	UMLS:C4024936	hp.json		http://purl.obolibrary.org/obo/HP_0007112		
HP:0009774	biolink:PhenotypicFeature	Triangular shaped phalanges of the hand		UMLS:C2673397	hp.json	Delta phalanx/delta-like phalanx|Triangular shaped hand bones	http://purl.obolibrary.org/obo/HP_0009774		
HP:0009777	biolink:PhenotypicFeature	Absent thumb	Absent thumb, i.e., the absence of both phalanges of a thumb and the associated soft tissues.	UMLS:C3278811	hp.json	Absent thumbs|Aplasia of the thumb|Absent thumb|Thumb aplasia	http://purl.obolibrary.org/obo/HP_0009777		hposlim_core
HP:0009776	biolink:PhenotypicFeature	Adactyly	The absence of all phalanges of all the digits of a limb and the associated soft tissues.	SNOMEDCT_US:275348004|UMLS:C4280394|UMLS:C0238591|Fyler:4173	hp.json	Absent fingers or toes|Aphalangy	http://purl.obolibrary.org/obo/HP_0009776		hposlim_core
PR:P06800	biolink:Protein	receptor-type tyrosine-protein phosphatase C (mouse)	A receptor-type tyrosine-protein phosphatase C that is encoded in the genome of mouse.	UniProtKB:P06800	hp.json	Ly-5|CD45 (mouse)|leukocyte common antigen (mouse)|lymphocyte antigen 5 (mouse)|mPTPRC|L-CA (mouse)|T200 (mouse)|Ptprc	http://purl.obolibrary.org/obo/PR_P06800		
HP:0007115	biolink:PhenotypicFeature	Orbital encephalocele		SNOMEDCT_US:15671007|UMLS:C0271330	hp.json		http://purl.obolibrary.org/obo/HP_0007115		
HP:0009771	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the hand	Dissolution or degeneration of bone tissue of the phalanges of the hand.	SNOMEDCT_US:63122002|MSH:D030981|SNOMEDCT_US:27201004|UMLS:C0917990	hp.json	Acroosteolysis|Acro-osteolysis|Breakdown of small bones of fingers	http://purl.obolibrary.org/obo/HP_0009771		
CHEBI:50320	biolink:ChemicalSubstance	nucleoside residue			hp.json	nucleoside residues	http://purl.obolibrary.org/obo/CHEBI_50320		3_STAR
HP:0009770	biolink:PhenotypicFeature	Curved phalanges of the hand		UMLS:C4024211	hp.json	Curved hand bones	http://purl.obolibrary.org/obo/HP_0009770		
HP:0009773	biolink:PhenotypicFeature	Symphalangism affecting the phalanges of the hand	Fusion of two or more phalangeal bones of the hand.	UMLS:C4021390	hp.json	Fused finger bones of the hand|Synostosis involving phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009773		
HP:0007110	biolink:PhenotypicFeature	Central hypoventilation		UMLS:C3805839	hp.json		http://purl.obolibrary.org/obo/HP_0007110		
HP:0007111	biolink:PhenotypicFeature	Chronic hepatic encephalopathy		UMLS:C4024937	hp.json		http://purl.obolibrary.org/obo/HP_0007111		
HP:0009772	biolink:PhenotypicFeature	Patchy sclerosis of finger phalanx	Uneven (irregular) increase in bone density of one or more of the phalanges of the hand.	UMLS:C1857508	hp.json	Uneven increase in bone density in finger bone|Phalangeal sclerosis|Patchy sclerosis of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0009772		
CHEBI:50313	biolink:ChemicalSubstance	onium cation	Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families.		hp.json	onium cations|onium cations|onium ion|onium ions	http://purl.obolibrary.org/obo/CHEBI_50313		3_STAR
CHEBI:50312	biolink:ChemicalSubstance	onium compound			hp.json		http://purl.obolibrary.org/obo/CHEBI_50312		1_STAR
CHEBI:25355	biolink:ChemicalSubstance	mitochondrial respiratory-chain inhibitor			hp.json	mitochondrial electron transport chain inhibitors|mitochondrial respiratory chain inhibitors|mitochondrial electron-transport chain inhibitor	http://purl.obolibrary.org/obo/CHEBI_25355		3_STAR
UBERON:2007013	biolink:AnatomicalEntity	preplacodal ectoderm	Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes.	ZFA:0007013	hp.json		http://purl.obolibrary.org/obo/UBERON_2007013		
CHEBI:50315	biolink:ChemicalSubstance	chloronium		Gmelin:331	hp.json	H2Cl(+)|chloranium|chloronium|[ClH2](+)	http://purl.obolibrary.org/obo/CHEBI_50315		3_STAR
HP:0010742	biolink:PhenotypicFeature	Edema of the upper limbs	An abnormal accumulation of fluid beneath the skin of the arms.	UMLS:C0522035|SNOMEDCT_US:102558002	hp.json	Fluid accumulation in upper limbs|Oedema of the upper limbs	http://purl.obolibrary.org/obo/HP_0010742		
HP:0010741	biolink:PhenotypicFeature	Pedal edema	An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg.	SNOMEDCT_US:102572006|UMLS:C0239340|UMLS:C0235886	hp.json	Fluid accumulation in lower limbs|Pedal oedema|Dependant edema|Edema of the lower limbs|Oedema of the lower limbs|Peripheral oedema of lower extremity|Leg oedema|Dependant oedema|Lower leg swelling|Leg edema|Peripheral edema of lower extremity	http://purl.obolibrary.org/obo/HP_0010741		
HP:0010740	biolink:PhenotypicFeature	Osteopathia striata	A lamellar pattern visible on radiographs and mainly localized at the metaphyses of the long tubular bones. Pathologic-anatomical studies revealed that these benign signs on x-rays are the result of a juvenile metaphyseal bone necrosis. Calcifications in the necrotic marrow lead to this lamellar or lattice-like appearance.	UMLS:C0265513|SNOMEDCT_US:82663009	hp.json		http://purl.obolibrary.org/obo/HP_0010740		
CHEBI:50319	biolink:ChemicalSubstance	nucleotide residue			hp.json	nucleotide residues	http://purl.obolibrary.org/obo/CHEBI_50319		3_STAR
CHEBI:25354	biolink:ChemicalSubstance	mineralocorticoid	Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism.		hp.json	mineralocorticoids	http://purl.obolibrary.org/obo/CHEBI_25354		3_STAR
CHEBI:49323	biolink:ChemicalSubstance	contraceptive drug	A chemical substance that prevents or reduces the probability of conception.		hp.json	contraceptive agent|contraceptive drugs	http://purl.obolibrary.org/obo/CHEBI_49323		3_STAR
HP:0010749	biolink:PhenotypicFeature	Blepharochalasis	Blepharochalasis is characterized by recurrent, non-painful, nonerythematous episodes of eyelid edema. It has been divided into hypertrophic and atrophic forms. In the hypertrophic form recurrent edema results in orbital fat herniation through a weakened orbital septum. Most patients who have blepharochalasis present in an atrophic condition with atrophy of redundant eyelid skin and superior nasal fat pads.	UMLS:C0005742|SNOMEDCT_US:47704002	hp.json	Saggy upper eyelid skin	http://purl.obolibrary.org/obo/HP_0010749		hposlim_core
HP:0010748	biolink:PhenotypicFeature	Ectopic lacrimal punctum	Positioning of a lacrimal punctum other than at the medial margins of the eyelid.	UMLS:C4021230	hp.json	Abnormal position of the lacrimal punctum	http://purl.obolibrary.org/obo/HP_0010748		hposlim_core
HP:0010747	biolink:PhenotypicFeature	Medial flaring of the eyebrow	An abnormal distribution of eyebrow hair growth in the medial direction.	UMLS:C1844562	hp.json	Medially flared eyebrows	http://purl.obolibrary.org/obo/HP_0010747		hposlim_core
HP:0009746	biolink:PhenotypicFeature	Thick nasal septum	Abnormally increased thickness of the nasal septum.	UMLS:C1844810	hp.json	Broad septum of nose|Wide septum of nose|Thick nasal septum|Broad nasal septum|Wide nasal septum|Thick septum of nose	http://purl.obolibrary.org/obo/HP_0009746		
HP:0010746	biolink:PhenotypicFeature	Hypoplasia of the phalanges of the toes		UMLS:C4023715	hp.json	Small toe bones	http://purl.obolibrary.org/obo/HP_0010746		
HP:0009745	biolink:PhenotypicFeature	Spinal arachnoid cyst	Presence of arachnoid cysts of the spinal canal extradurally in the epidural space.	UMLS:C4021393	hp.json	Epidural arachnoid cysts of the spinal canal	http://purl.obolibrary.org/obo/HP_0009745		
HP:0010745	biolink:PhenotypicFeature	Aplasia of the phalanges of the toes	Absence of a digit or of one or more phalanges of a toe.	UMLS:C4021231	hp.json	Absent bones of the toes|Aphalangia of the toes	http://purl.obolibrary.org/obo/HP_0010745		
HP:0009748	biolink:PhenotypicFeature	Large earlobe	Increased volume of the earlobe, that is, abnormally prominent ear lobules.	UMLS:C1844573	hp.json	Prominent ear lobes|Large earlobe|Fleshy earlobes|Fleshy earlobe|Prominent ear lobules	http://purl.obolibrary.org/obo/HP_0009748		hposlim_core
HP:0010744	biolink:PhenotypicFeature	Absent metatarsal bone	A developmental abnormality characterized by the absence (aplasia) of a metatarsal bone.	UMLS:C4021232	hp.json	Absent long bone of foot|Aplasia of the metatarsal bones	http://purl.obolibrary.org/obo/HP_0010744		
HP:0010743	biolink:PhenotypicFeature	Short metatarsal	Diminished length of a metatarsal bone, with resultant proximal displacement of the associated toe.	UMLS:C1849020	hp.json	Hypoplastic metatarsals|Short long bone of foot|Short metatarsal bone|Short metatarsals|Short metatarsal bones|Hypoplasia of the metatarsal bones|Shortened metatarsals	http://purl.obolibrary.org/obo/HP_0010743		hposlim_core
HP:0009747	biolink:PhenotypicFeature	Lumbosacral hirsutism	Abnormally increased hair growth in the lumbosacral region.	UMLS:C1851095	hp.json		http://purl.obolibrary.org/obo/HP_0009747		
HP:0009742	biolink:PhenotypicFeature	Stiff shoulders	Shoulder joint stiffness is a perceived sensation of tightness in shoulders when attempting to move them after a period of inactivity.	UMLS:C0241042|SNOMEDCT_US:249918006	hp.json	Stiff shoulders	http://purl.obolibrary.org/obo/HP_0009742		
HP:0009741	biolink:PhenotypicFeature	Nephrosclerosis	Nephrosclerosis refers to thickening or scarring ("sclerosis") resulting from damage to the renal arterioles, also referred to as arteriosclerosis of the kidney arteries.	SNOMEDCT_US:32916005|MSH:D009400|UMLS:C0027719	hp.json	Scarring of kidney arteries|Thickening of kidney artiries	http://purl.obolibrary.org/obo/HP_0009741		
HP:0009744	biolink:PhenotypicFeature	Abnormal spinal dura mater morphology	An abnormality of the spinal dura mater, which is the outermost of the three layers of the meninges surrounding the spinal cord.	UMLS:C4024214	hp.json	Abnormality of the spinal dura mater	http://purl.obolibrary.org/obo/HP_0009744		
HP:0009743	biolink:PhenotypicFeature	Distichiasis	Double rows of eyelashes.	SNOMEDCT_US:95339000|UMLS:C0423848	hp.json	Distichiasis of eyelid eyelashes	http://purl.obolibrary.org/obo/HP_0009743		hposlim_core
HP:0009740	biolink:PhenotypicFeature	Aplasia of the parotid gland	Absence of the parotid gland.	UMLS:C4020779|UMLS:C1400252|UMLS:C4024215	hp.json	Abnormally small parotid gland|Hypoplasia of parotid gland|Absence of the parotid gland|Underdevelopment of parotid gland	http://purl.obolibrary.org/obo/HP_0009740		
UBERON:0002926	biolink:AnatomicalEntity	gustatory epithelium	A sensory epithelium that is part of a gustatory system.	FMA:62412|http://uri.neuinfo.org/nif/nifstd/nifext_12	hp.json		http://purl.obolibrary.org/obo/UBERON_0002926		
UBERON:0002925	biolink:AnatomicalEntity	trigeminal nucleus	A nucleus of brain that is part of a trigeminal nuclear complex.	EV:0100271|EMAPA:35883|VHOG:0001353|BTO:0001074|MA:0001028|CALOHA:TS-2077|FMA:71247|UMLS:C0040999|BM:V|MESH:D014278|SCTID:280164007|http://uri.neuinfo.org/nif/nifstd/nifext_11|NCIT:C12807|GAID:604	hp.json	nucleus tractus mesencephali nervi trigeminalis|nucleus mesencephalicus nervi trigemini|trigeminal V nucleus|nucleus of trigeminal nuclear complex|trigeminal nucleus|nucleus mesencephalicus trigeminalis|trigeminal nuclear complex nucleus	http://purl.obolibrary.org/obo/UBERON_0002925		uberon_slim
UBERON:0002928	biolink:AnatomicalEntity	dentate gyrus polymorphic layer	A cellular layer of the dentate gyrus enclosed by the granule cell layer. A number of cell types are located in the polymorphic layer but the most prominent is the mossy cell.	BIRNLEX:4128|MBA:10704|MA:0002864|NLX:42439|EMAPA:35280|BAMS:PoDG|BAMS:po	hp.json	CA4|polymorph layer of the dentate gyrus	http://purl.obolibrary.org/obo/UBERON_0002928		
CHEBI:25367	biolink:ChemicalSubstance	molecule	Any polyatomic entity that is an electrically neutral entity consisting of more than one atom.		hp.json	molecula|neutral molecular compounds|molecules|molecule|Molekuel	http://purl.obolibrary.org/obo/CHEBI_25367		3_STAR
UBERON:0002921	biolink:AnatomicalEntity	longitudinal fissure	The deep groove which separates the two hemispheres of the vertebrate brain. The falx cerebri, a dural brain covering, lies within the medial longitudinal fissure. [WP,unvetted].	OpenCyc:Mx4rwJlWu5wpEbGdrcN5Y29ycA|UMLS:C0228186|DHBA:10622|HBA:9401|BAMS:lf|NCIT:C33005|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=35|UMLS:C0228186|BAMS:lfh|BIRNLEX:4041|FMA:83727	hp.json	sagittal fissure|fissura interhemispherica|longitudinal cerebral fissure|fissura longitudinalis magna|hemispheric sulcus|fissura longitudinalis cerebri|LF|longitudinal fissure of the cerebrum|fissura longitudinalis cerebrales|longitudinal fissure of hemisphere|medial longitudinal fissure|interhemispheric fissure|longitudinal sulcus	http://purl.obolibrary.org/obo/UBERON_0002921		pheno_slim|uberon_slim
HP:0010731	biolink:PhenotypicFeature	Extension of eyebrows towards upper eyelid	The eyebrows extend towards - or even all the way down to - the margin of the upper eyelid.	UMLS:C4023717	hp.json	Extension of eyebrows towards upper eyelid	http://purl.obolibrary.org/obo/HP_0010731		
HP:0010730	biolink:PhenotypicFeature	Double eyebrow	This may present as a partial or complete duplication of the eyebrows.	SNOMEDCT_US:253209004|UMLS:C0431449	hp.json	Double eyebrow|Duplication of eyebrow	http://purl.obolibrary.org/obo/HP_0010730		hposlim_core
CHEBI:25362	biolink:ChemicalSubstance	elemental molecule	A molecule all atoms of which have the same atomic number.		hp.json	homoatomic molecule|homoatomic molecules	http://purl.obolibrary.org/obo/CHEBI_25362		3_STAR
HP:0010739	biolink:PhenotypicFeature	Osteopoikilosis	Osteopoikilosis is a benign, asymptomatic sclerotic dysplasia of the bones. It affects both male and female and may be seen at any age. Radiographically sclerotic circular or ovoid lesions are usually symmetrically distributed in a periarticular location. Lesions can increase or decrease in size and number in serial radiographs or even disappear and do not have increased bone radiotracer uptake.	SNOMEDCT_US:9147009|UMLS:C0029455|MSH:D010023	hp.json		http://purl.obolibrary.org/obo/HP_0010739		
HP:0010736	biolink:PhenotypicFeature	Monostotic fibrous dysplasia	Fibrous dysplasia of the bones were lesions are localized in only one bone.	UMLS:C0016064|SNOMEDCT_US:89859004|MSH:D005358	hp.json		http://purl.obolibrary.org/obo/HP_0010736		
UBERON:0014907	biolink:AnatomicalEntity	intersomitic vessel	One of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites.	ZFA:0001285|EMAPA:37389|TAO:0001285|XAO:0004075|EFO:0003664	hp.json	segmental vessel|intersomitic vessels|intersomitic blood vessel|intersegmental vessel|intersegmental vessels	http://purl.obolibrary.org/obo/UBERON_0014907		pheno_slim
HP:0009757	biolink:PhenotypicFeature	Intercrural pterygium	A pterygium (or pterygia) in the intercrural (groin) region.	UMLS:C3810471	hp.json		http://purl.obolibrary.org/obo/HP_0009757		
HP:0010735	biolink:PhenotypicFeature	Polyostotic fibrous dysplasia	Fibrous dysplasia of the bones were lesions are localized in many bones throughout of the body. Polyostotic fibrous dysplasia is a cardinal feature of McCune-Albright syndrome.	SNOMEDCT_US:36517007|UMLS:C0016065|MSH:D005359	hp.json		http://purl.obolibrary.org/obo/HP_0010735		
HP:0009756	biolink:PhenotypicFeature	Popliteal pterygium	A pterygium (or pterygia) occurring in the popliteal region (the back of the knee).	UMLS:C3805420	hp.json		http://purl.obolibrary.org/obo/HP_0009756		hposlim_core
HP:0010734	biolink:PhenotypicFeature	Fibrous dysplasia of the bones	Tumor-like growths that consist of replacement of the medullary bone with fibrous tissue, causing the expansion and weakening of the areas of bone involved. Especially when involving the skull or facial bones, the lesions can cause externally visible deformities. The skull is often, but not necessarily, affected, and any other bone or bones may be involved. Fibrous dysplasia can either effect isolated bones (Monostotic fibrous dysplasia) or also generalized all bones of the body (Polyostotic fibrous dysplasia).	SNOMEDCT_US:10623005|UMLS:C0016063|MSH:D005357	hp.json		http://purl.obolibrary.org/obo/HP_0010734		
HP:0009759	biolink:PhenotypicFeature	Neck pterygia	Pterygia affecting the neck.	UMLS:C1849577	hp.json	Neck pterygium	http://purl.obolibrary.org/obo/HP_0009759		
HP:0010733	biolink:PhenotypicFeature	Naevus flammeus of the eyelid	Naevus flammeus localised in the skin of the eyelid.	UMLS:C1854409	hp.json	Port-wine stain on eyelid	http://purl.obolibrary.org/obo/HP_0010733		
UBERON:0014903	biolink:AnatomicalEntity	primordial vasculature	A portion of tissue that will develop into vasculature.	TAO:0005076|EFO:0003708|ZFA:0005076	hp.json		http://purl.obolibrary.org/obo/UBERON_0014903		
HP:0010732	biolink:PhenotypicFeature	Nodular changes affecting the eyelids	Nodular changes affecting the eyelids may have many different causes such as cystic lesions (chalaziae, hordeolae), lipogranulomas, melanomas, infectious diseases (Molluscum contagiosum) and many more.	UMLS:C4023716	hp.json	Eyelid nodules	http://purl.obolibrary.org/obo/HP_0010732		
HP:0009758	biolink:PhenotypicFeature	Pyramidal skinfold extending from the base to the top of the nails	Pyramidal skinfold extending from the base to the top of the nails is a rare and distinctive anomaly seen in popliteal pterygia syndrome.	UMLS:C4024212	hp.json		http://purl.obolibrary.org/obo/HP_0009758		
HP:0009752	biolink:PhenotypicFeature	Cleft in skull base	A bony defect in the skull base.	UMLS:C1856027	hp.json	Cleft in cranial base|Cleft in skull base	http://purl.obolibrary.org/obo/HP_0009752		
HP:0009755	biolink:PhenotypicFeature	Ankyloblepharon	Partial fusion of the upper and lower eyelid margins by single or multiple bands of tissue.	SNOMEDCT_US:400952003|UMLS:C0339182|SNOMEDCT_US:193953008|MSH:C536373|UMLS:C1302999	hp.json	Ankyloblepharon filiforme adnatum|Eyelids stuck together|Adhesion of eyelids|Eyelid synechiae	http://purl.obolibrary.org/obo/HP_0009755		hposlim_core
HP:0009754	biolink:PhenotypicFeature	Fibrous syngnathia	Complete or nearly complete soft tissue fusion of the alveolar ridges.	UMLS:C4021392	hp.json	Alveolar synechiae|Fusion of the alveolar ridges	http://purl.obolibrary.org/obo/HP_0009754		hposlim_core
HP:0009751	biolink:PhenotypicFeature	Aplasia of the pectoralis major muscle	Absence of the pectoralis major muscle.	UMLS:C4024213	hp.json	Absent pectoralis major muscle	http://purl.obolibrary.org/obo/HP_0009751		
GO:0072330	biolink:BiologicalProcess	monocarboxylic acid biosynthetic process	The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group.		hp.json	monocarboxylic acid biosynthesis|monocarboxylic acid anabolism|monocarboxylic acid synthesis|monocarboxylic acid formation	http://purl.obolibrary.org/obo/GO_0072330		
CL:0002427	biolink:Cell	resting double-positive thymocyte	A double-positive, alpha-beta thymocyte that is small and not proliferating.		hp.json	T.DP.sm.Th	http://purl.obolibrary.org/obo/CL_0002427		
GO:1902533	biolink:BiologicalProcess	positive regulation of intracellular signal transduction	Any process that activates or increases the frequency, rate or extent of intracellular signal transduction.		hp.json	activation of signal transduction via intracellular signaling cascade|up-regulation of signal transmission via intracellular cascade|up regulation of intracellular signal transduction|up regulation of intracellular signal transduction pathway|activation of intracellular signal transduction|upregulation of intracellular signaling chain|upregulation of intracellular signaling cascade|positive regulation of intracellular signal transduction pathway|up regulation of signal transmission via intracellular cascade|up-regulation of intracellular signaling pathway|positive regulation of signal transmission via intracellular cascade|up-regulation of signal transduction via intracellular signaling cascade|up regulation of intracellular signaling pathway|upregulation of intracellular signal transduction pathway|upregulation of intracellular signal transduction|activation of intracellular signal transduction pathway|positive regulation of intracellular signaling pathway|up regulation of signal transduction via intracellular signaling cascade|upregulation of signal transmission via intracellular cascade|up-regulation of intracellular signaling chain|up-regulation of intracellular signaling cascade|activation of signal transmission via intracellular cascade|activation of intracellular signaling cascade|positive regulation of signal transduction via intracellular signaling cascade|positive regulation of intracellular protein kinase cascade|up regulation of intracellular signaling chain|up regulation of intracellular signaling cascade|activation of intracellular signaling chain|upregulation of intracellular signaling pathway|activation of intracellular signaling pathway|positive regulation of intracellular signaling chain|up-regulation of intracellular signal transduction pathway|up-regulation of intracellular signal transduction|upregulation of signal transduction via intracellular signaling cascade|positive regulation of intracellular signaling cascade	http://purl.obolibrary.org/obo/GO_1902533		
CL:0002429	biolink:Cell	CD69-positive double-positive thymocyte	A double-positive thymocyte that is CD69-positive and has begun positive selection.		hp.json	T.DP69+.Th	http://purl.obolibrary.org/obo/CL_0002429		
CL:0002428	biolink:Cell	double-positive blast	A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating.		hp.json	activated double-positive thymocyte|T.DPb.Th	http://purl.obolibrary.org/obo/CL_0002428		
GO:1902531	biolink:BiologicalProcess	regulation of intracellular signal transduction	Any process that modulates the frequency, rate or extent of intracellular signal transduction.		hp.json	regulation of intracellular signaling pathway|regulation of intracellular protein kinase cascade|regulation of intracellular signaling cascade|regulation of signal transduction via intracellular signaling cascade|regulation of intracellular signaling chain|regulation of intracellular signal transduction pathway|regulation of signal transmission via intracellular cascade	http://purl.obolibrary.org/obo/GO_1902531		
GO:1902532	biolink:BiologicalProcess	negative regulation of intracellular signal transduction	Any process that stops, prevents or reduces the frequency, rate or extent of intracellular signal transduction.		hp.json	downregulation of intracellular signaling cascade|down regulation of intracellular signaling pathway|downregulation of signal transmission via intracellular cascade|negative regulation of intracellular signaling chain|down-regulation of intracellular signaling chain|down regulation of signal transduction via intracellular signaling cascade|down-regulation of intracellular signaling cascade|down-regulation of signal transmission via intracellular cascade|inhibition of intracellular signal transduction pathway|downregulation of intracellular signaling pathway|down regulation of intracellular signaling chain|inhibition of signal transmission via intracellular cascade|inhibition of intracellular signaling cascade|downregulation of signal transduction via intracellular signaling cascade|down-regulation of intracellular signal transduction|negative regulation of intracellular signal transduction pathway|down-regulation of intracellular signal transduction pathway|inhibition of intracellular signaling chain|downregulation of intracellular signaling chain|inhibition of intracellular signaling pathway|negative regulation of signal transmission via intracellular cascade|down regulation of intracellular signal transduction|down regulation of intracellular signal transduction pathway|inhibition of signal transduction via intracellular signaling cascade|down regulation of signal transmission via intracellular cascade|down regulation of intracellular signaling cascade|inhibition of intracellular signal transduction|negative regulation of intracellular signaling pathway|down-regulation of intracellular signaling pathway|downregulation of intracellular signal transduction|negative regulation of intracellular protein kinase cascade|negative regulation of intracellular signaling cascade|downregulation of intracellular signal transduction pathway|negative regulation of signal transduction via intracellular signaling cascade|down-regulation of signal transduction via intracellular signaling cascade	http://purl.obolibrary.org/obo/GO_1902532		
GO:0060350	biolink:BiologicalProcess	endochondral bone morphogenesis	The process in which bones are generated and organized as a result of the conversion of initial cartilaginous anlage into bone.		hp.json		http://purl.obolibrary.org/obo/GO_0060350		
GO:0060351	biolink:BiologicalProcess	cartilage development involved in endochondral bone morphogenesis	The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones.		hp.json		http://purl.obolibrary.org/obo/GO_0060351		
CL:0002421	biolink:Cell	nucleated reticulocyte	A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles.		hp.json		http://purl.obolibrary.org/obo/CL_0002421		
CL:0002420	biolink:Cell	immature T cell	A T cell that has not completed T cell selection.	CALOHA:TS-1042|BTO:0001372	hp.json	immature T-cell	http://purl.obolibrary.org/obo/CL_0002420		
CL:0002422	biolink:Cell	enucleated reticulocyte	A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes.	CALOHA:TS-0864|FMA:66785	hp.json		http://purl.obolibrary.org/obo/CL_0002422		
CL:0002425	biolink:Cell	early T lineage precursor	A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive.		hp.json	ETP|preT.ETP.Th	http://purl.obolibrary.org/obo/CL_0002425		
GO:0060359	biolink:BiologicalProcess	response to ammonium ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.		hp.json	response to ammonia	http://purl.obolibrary.org/obo/GO_0060359		
CL:0002437	biolink:Cell	mature CD8 single-positive thymocyte	A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor.		hp.json	T.8SP24-.Th	http://purl.obolibrary.org/obo/CL_0002437		
GO:0060341	biolink:BiologicalProcess	regulation of cellular localization	Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.		hp.json	regulation of cellular localisation	http://purl.obolibrary.org/obo/GO_0060341		
CL:0002430	biolink:Cell	CD4-intermediate, CD8-positive double-positive thymocyte	A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor.		hp.json	T.4int8+.Th|T_4int8+_Th	http://purl.obolibrary.org/obo/CL_0002430		
GO:0060343	biolink:BiologicalProcess	trabecula formation	The process of creating a trabecula in an organ. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.		hp.json	trabecula biogenesis|trabeculation	http://purl.obolibrary.org/obo/GO_0060343		
CL:0002432	biolink:Cell	CD24-positive, CD4 single-positive thymocyte	A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor.		hp.json	T.4SP24int.Th|CD24-positive, CD4 single-positive semimature thymocyte	http://purl.obolibrary.org/obo/CL_0002432		
CL:0002431	biolink:Cell	CD4-positive, CD8-intermediate double-positive thymocyte	A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor.		hp.json	T.4+8int.Th|T_4+8int_Th	http://purl.obolibrary.org/obo/CL_0002431		
CL:0002434	biolink:Cell	CD24-positive, CD8 single-positive thymocyte	A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor.		hp.json	T.8SP24int.Th|CD24-positive, CD8 single-positive semimature thymocyte	http://purl.obolibrary.org/obo/CL_0002434		
CL:0002433	biolink:Cell	CD69-positive, CD4-positive single-positive thymocyte	A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive.		hp.json	intermediate CD4-single-positive|T.4SP69+.Th	http://purl.obolibrary.org/obo/CL_0002433		
GO:0060348	biolink:BiologicalProcess	bone development	The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.		hp.json		http://purl.obolibrary.org/obo/GO_0060348		
CL:0002436	biolink:Cell	mature CD4 single-positive thymocyte	A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor.		hp.json	T.4SP24-.Th	http://purl.obolibrary.org/obo/CL_0002436		
CL:0002435	biolink:Cell	CD69-positive, CD8-positive single-positive thymocyte	A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive.		hp.json	intermediate CD8-single-positive|T.8SP69+.Th	http://purl.obolibrary.org/obo/CL_0002435		
GO:0060349	biolink:BiologicalProcess	bone morphogenesis	The process in which bones are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060349		
GO:0035372	biolink:BiologicalProcess	protein localization to microtubule	A process in which a protein is transported to, or maintained at, a microtubule.		hp.json	protein localisation to microtubule	http://purl.obolibrary.org/obo/GO_0035372		
GO:0098974	biolink:BiologicalProcess	postsynaptic actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.		hp.json		http://purl.obolibrary.org/obo/GO_0098974		goslim_synapse
GO:0098975	biolink:CellularComponent	postsynapse of neuromuscular junction	The postsynapse of a neuromuscular junction. In vertebrate muscles this includes the motor end-plate, consisting of postjunctional folds of the sarcolemma.		hp.json		http://purl.obolibrary.org/obo/GO_0098975		
GO:0072350	biolink:BiologicalProcess	tricarboxylic acid metabolic process	The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing three carboxyl (COOH) groups or anions (COO-).		hp.json	tricarboxylic acid metabolism	http://purl.obolibrary.org/obo/GO_0072350		
GO:0060379	biolink:BiologicalProcess	cardiac muscle cell myoblast differentiation	The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.		hp.json	myocardial precursor cell differentiation|cardiac myoblast differentiation	http://purl.obolibrary.org/obo/GO_0060379		
GO:0072359	biolink:BiologicalProcess	circulatory system development	The process whose specific outcome is the progression of the circulatory system over time, from its formation to the mature structure. The circulatory system is the organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis.		hp.json	cardiovascular system development	http://purl.obolibrary.org/obo/GO_0072359		goslim_drosophila
GO:1902564	biolink:BiologicalProcess	negative regulation of neutrophil activation	Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation.		hp.json	down-regulation of neutrophil activation|down regulation of neutrophil activation|inhibition of neutrophil activation|downregulation of neutrophil activation	http://purl.obolibrary.org/obo/GO_1902564		
GO:1902565	biolink:BiologicalProcess	positive regulation of neutrophil activation	Any process that activates or increases the frequency, rate or extent of neutrophil activation.		hp.json	up regulation of neutrophil activation|activation of neutrophil activation|upregulation of neutrophil activation|up-regulation of neutrophil activation	http://purl.obolibrary.org/obo/GO_1902565		
CL:0002419	biolink:Cell	mature T cell	A T cell that expresses a T cell receptor complex and has completed T cell selection.		hp.json	mature T-cell|CD3epsilon T cell|CD3e-positive T cell	http://purl.obolibrary.org/obo/CL_0002419		
GO:0060363	biolink:BiologicalProcess	cranial suture morphogenesis	The process in which any suture between cranial bones is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0060363		
GO:1902563	biolink:BiologicalProcess	regulation of neutrophil activation	Any process that modulates the frequency, rate or extent of neutrophil activation.		hp.json		http://purl.obolibrary.org/obo/GO_1902563		
GO:1902570	biolink:BiologicalProcess	protein localization to nucleolus	A process in which a protein is transported to, or maintained in, a location within a nucleolus.		hp.json	protein localisation to nucleolus|protein localisation in nucleolus|protein localization in nucleolus	http://purl.obolibrary.org/obo/GO_1902570		
GO:0072348	biolink:BiologicalProcess	sulfur compound transport	The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	sulfur-containing compound transport	http://purl.obolibrary.org/obo/GO_0072348		
PR:P41159	biolink:Protein	leptin (human)	A leptin that is encoded in the genome of human.	UniProtKB:P41159	hp.json	OB|OBS|obesity factor (human)|hLEP|LEP|obese protein (human)	http://purl.obolibrary.org/obo/PR_P41159		
CHEBI:50299	biolink:ChemicalSubstance	canonical ribonucleotide residue			hp.json	canonical ribonucleotide residues	http://purl.obolibrary.org/obo/CHEBI_50299		3_STAR
GO:0072378	biolink:BiologicalProcess	blood coagulation, fibrin clot formation	A protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.		hp.json		http://purl.obolibrary.org/obo/GO_0072378		
GO:0072377	biolink:BiologicalProcess	blood coagulation, common pathway	A protein activation cascade that contributes to blood coagulation and consists of events leading from the formation of activated factor X to the formation of active thrombin, the cleavage of fibrinogen by thrombin, and the formation of cleaved fibrin into a stable multimeric, cross-linked complex.		hp.json		http://purl.obolibrary.org/obo/GO_0072377		
CHEBI:50297	biolink:ChemicalSubstance	canonical nucleotide residue			hp.json	canonical nucleotide residues	http://purl.obolibrary.org/obo/CHEBI_50297		3_STAR
GO:0072376	biolink:BiologicalProcess	protein activation cascade	A response to a stimulus that consists of a sequential series of modifications to a set of proteins where the product of one reaction acts catalytically in the following reaction. The magnitude of the response is typically amplified at each successive step in the cascade. Modifications typically include proteolysis or covalent modification, and may also include binding events.		hp.json	protein activitory cascade|protein activation pathway	http://purl.obolibrary.org/obo/GO_0072376		
GO:0072360	biolink:BiologicalProcess	vascular cord development	The progression of the vascular cord over time from its initial formation until its mature state. The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis.		hp.json		http://purl.obolibrary.org/obo/GO_0072360		
HP:5000035	biolink:PhenotypicFeature	Anti-TRIM46 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the axon initial segment protein tripartite motif 46 (TRIM46).		hp.json		http://purl.obolibrary.org/obo/HP_5000035		
HP:5000036	biolink:PhenotypicFeature	Anti-TRIM9/TRIM67 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against TRIM9/TRIM67.		hp.json		http://purl.obolibrary.org/obo/HP_5000036		
HP:5000037	biolink:PhenotypicFeature	Anti-Yo antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Yo.		hp.json	Anti-Purkinje cell cytoplasmic antibody 1	http://purl.obolibrary.org/obo/HP_5000037		
HP:5000038	biolink:PhenotypicFeature	Anti-titin antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against titin.		hp.json		http://purl.obolibrary.org/obo/HP_5000038		
HP:5000039	biolink:PhenotypicFeature	Anti-Zic4 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Zic family member 4 (ZIC4).		hp.json		http://purl.obolibrary.org/obo/HP_5000039		
HP:5000030	biolink:PhenotypicFeature	Anti-Ri antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ri, ,an antineuronal antibody.		hp.json	Anti-ANNA-2 antibody	http://purl.obolibrary.org/obo/HP_5000030		
HP:5000031	biolink:PhenotypicFeature	Anti-Septin-5 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Septin-5.		hp.json		http://purl.obolibrary.org/obo/HP_5000031		
HP:5000032	biolink:PhenotypicFeature	Anti-SEZ6L2 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against seizure-related 6 homolog like 2 (SEZ6L2).		hp.json		http://purl.obolibrary.org/obo/HP_5000032		
HP:5000033	biolink:PhenotypicFeature	Anti-SOX1 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against SOX1. Anti-SOX1 antibodies, also known as antiglial nuclear antibody (AGNA), are specifically found in paraneoplastic neurological disorders. Since SOX1 is expressed in neuronal precursor cells in the developing central nervous system, it has been used as an early marker of neural stem cells.		hp.json	Anti-Sry-like high mobility group box (SOX) 1 antibody	http://purl.obolibrary.org/obo/HP_5000033		
HP:5000034	biolink:PhenotypicFeature	Anti-Tr/DNER antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Tr/DNER. Anti-Tr antibodies are directed against cerebellar Purkinje cells (termed anti-Tr or PCA-Tr). Anti-Tr autoantibodies are frequently associated with Hodgkin lymphoma (HL). Anti-Tr antibodies are defined by a specific staining pattern in cerebellar tissue that is characterized by punctate immunoreactivity in both the dendritic tree and soma of Purkinje cells but not in their axons. This characteristic pattern is indicative of the presence of anti-Tr antibodies. The Delta/Notch-like epidermal growth factor-related receptor (DNER) was identified as the target antigen of anti-Tr.		hp.json	Anti-delta/notch-like epidermal growth factor-related receptor antibody|PCA-Tr	http://purl.obolibrary.org/obo/HP_5000034		
GO:0098988	biolink:MolecularActivity	G protein-coupled glutamate receptor activity	Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity.		hp.json	G-protein coupled glutamate receptor activity	http://purl.obolibrary.org/obo/GO_0098988		
GO:0072384	biolink:BiologicalProcess	organelle transport along microtubule	The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination.		hp.json	microtubule-based organelle localization	http://purl.obolibrary.org/obo/GO_0072384		
CHEBI:50267	biolink:ChemicalSubstance	protective agent	Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.		hp.json	chemoprotectant|chemoprotectants|protective agents|chemoprotective agents|chemoprotective agent	http://purl.obolibrary.org/obo/CHEBI_50267		3_STAR
HP:5000046	biolink:PhenotypicFeature	Anti-Lrp4 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against low-density lipoprotein receptor (Lrp4).		hp.json	Anti-low-density lipoprotein receptor-related protein 4 antibody	http://purl.obolibrary.org/obo/HP_5000046		
HP:5000047	biolink:PhenotypicFeature	Anti-ryanodine receptor antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ryanodine receptor.		hp.json	Anti-RyR antibody	http://purl.obolibrary.org/obo/HP_5000047		
HP:5000048	biolink:PhenotypicFeature	Anti-Kv1.4 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the voltage-gated potassium channel Kv1.4.		hp.json		http://purl.obolibrary.org/obo/HP_5000048		
HP:5000041	biolink:PhenotypicFeature	obsolete Anti-CRMP5 antibody positivity			hp.json		http://purl.obolibrary.org/obo/HP_5000041		
HP:5000042	biolink:PhenotypicFeature	Anti-Sj/ITPR1 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Sj/inositol 1,4,5-trisphosphate receptor.		hp.json	Anti-Sj/inositol 1,4,5-trisphosphate receptor antibody	http://purl.obolibrary.org/obo/HP_5000042		
HP:5000043	biolink:PhenotypicFeature	Anti-D2 R antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against dopamine-2 receptor.		hp.json	Anti-dopamine-2 receptors (D2R) antibody	http://purl.obolibrary.org/obo/HP_5000043		
HP:5000044	biolink:PhenotypicFeature	Anti-GluK2 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glutamate kainate receptor subunit 2 (GluK2).		hp.json	Anti-glutamate kainate receptor subunit 2 antibody	http://purl.obolibrary.org/obo/HP_5000044		
HP:5000045	biolink:PhenotypicFeature	obsolete Anti-MuSK antibody positivity			hp.json		http://purl.obolibrary.org/obo/HP_5000045		
CHEBI:50266	biolink:ChemicalSubstance	prodrug	A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.	PMID:25157234|PMID:25144792|PMID:25795057|PMID:28070577|PMID:23998799|Wikipedia:Prodrug|PMID:25269430|PMID:28219047|PMID:26028253|PMID:23993918|PMID:28334528|PMID:25620096|PMID:24628402|PMID:25391982|PMID:28329729|PMID:24329110|PMID:26184144|PMID:24709544|PMID:25591121|PMID:28215138|PMID:28259775|PMID:28319647	hp.json	Prodrugs	http://purl.obolibrary.org/obo/CHEBI_50266		3_STAR
CHEBI:50263	biolink:ChemicalSubstance	2-hydroxydicarboxylic acid	Any dicarboxylic acid carrying a hydroxy group on the carbon atom at position alpha to the carboxy group.	KEGG:C03668	hp.json	2-hydroxydicarboxylic acids|2-Hydroxydicarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_50263		3_STAR
HP:0032071	biolink:PhenotypicFeature	Eosinophilic pneumonia	The presence of eosinophils in lung tissue, generally as detected by tissue biopsy, with or without blood eosinophilia.		hp.json	Pulmonary eosinophilic infiltrate|Pulmonary eosinophilia|Eosinophilic pulmonary infiltration|Pulmonary eosinophilic infiltration	http://purl.obolibrary.org/obo/HP_0032071		
OBO:hp#is_observable_through	biolink:NamedThing	is_observable_through			hp.json		http://purl.obolibrary.org/obo/hp#is_observable_through		
HP:0032072	biolink:PhenotypicFeature	Popliteal synovial cyst	A fluid-filled mass that is a distention of a preexisting bursa in the popliteal fossa, most commonly the gastrocnemio-semimembranosus bursa. This bursa is unique in that it communicates with the knee joint, unlike other periarticular bursae, via an opening in the joint capsule posterior to the medial femoral condyle.		hp.json	Baker's cyst	http://purl.obolibrary.org/obo/HP_0032072		
HP:0032073	biolink:PhenotypicFeature	Aplasia of the fallopian tube	Aplasia, that is failure to develop, of the fallopian tube.		hp.json		http://purl.obolibrary.org/obo/HP_0032073		
GO:0050941	biolink:BiologicalProcess	negative regulation of pigment cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation.		hp.json	downregulation of pigment cell differentiation|down regulation of pigment cell differentiation|inhibition of pigment cell differentiation|down-regulation of pigment cell differentiation	http://purl.obolibrary.org/obo/GO_0050941		
HP:0032070	biolink:PhenotypicFeature	Leptomeningeal enhancement	Contrast material enhancement of the pia mater or enhancement that extends into the subarachnoid spaces of the sulci and cisterns is leptomeningeal enhancement. Leptomeningeal enhancement is usually associated with meningitis, which may be bacterial, viral, or fungal. The primary mechanism of this enhancement is breakdown of the blood-brain barrier without angiogenesis.		hp.json		http://purl.obolibrary.org/obo/HP_0032070		
GO:0050942	biolink:BiologicalProcess	positive regulation of pigment cell differentiation	Any process that activates or increases the frequency, rate or extent of pigment cell differentiation.		hp.json	up-regulation of pigment cell differentiation|activation of pigment cell differentiation|upregulation of pigment cell differentiation|up regulation of pigment cell differentiation|stimulation of pigment cell differentiation	http://purl.obolibrary.org/obo/GO_0050942		
HP:0032079	biolink:PhenotypicFeature	Medial degeneration	Medial degeneration of the aorta is to be used as an overarching term for any aortic surgical specimens that demonstrate one or more of the specific histopathologies mucoid extracellular matrix accumulation, elastic fiber fragmentation and/or loss, elastic fiber thinning, elastic fiber disorganization, smooth muscle cell nuclei loss, laminar medial collapse, smooth muscle cell disorganization, medial fibrosis. Grading of medial degeneration is based on the average overall severity of specific histopathologies as described, considering the worst area(s) sampled from multiple slides and aorta sections.		hp.json		http://purl.obolibrary.org/obo/HP_0032079		
HP:5000013	biolink:PhenotypicFeature	Anti-GFAP antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glial fibrillary acidic protein (GFAP).		hp.json	Anti-glial fibrillary acidic protein antibody	http://purl.obolibrary.org/obo/HP_5000013		
UBERON:0036376	biolink:AnatomicalEntity	wall of left ureter		FMA:15890	hp.json	left ureteral wall	http://purl.obolibrary.org/obo/UBERON_0036376		human_reference_atlas
UBERON:0036375	biolink:AnatomicalEntity	wall of right ureter		FMA:15889	hp.json	right ureteral wall	http://purl.obolibrary.org/obo/UBERON_0036375		
HP:5000014	biolink:PhenotypicFeature	Anti-GlyR antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Glycine receptor (GlyR).		hp.json	Anti-glycine receptor antibody	http://purl.obolibrary.org/obo/HP_5000014		
HP:5000015	biolink:PhenotypicFeature	Anti-Homer-3 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Homer-3.		hp.json	Anti-Homer protein homolog 3 antibody	http://purl.obolibrary.org/obo/HP_5000015		
HP:5000016	biolink:PhenotypicFeature	Anti-Hu antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Hu.		hp.json	Anti-ANNA-1 antibody|Anti-Neuronal Nuclear Antibody type-1 antibody	http://purl.obolibrary.org/obo/HP_5000016		
HP:0032075	biolink:PhenotypicFeature	Splenopancreatic fusion	Fusion of the pancreatic tail and spleen.		hp.json		http://purl.obolibrary.org/obo/HP_0032075		
HP:5000017	biolink:PhenotypicFeature	Anti-Iglon5 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against immunoglobulin-like cell adhesion molecule 5 (IgLON5).		hp.json	Anti-immunoglobulin-like cell adhesion molecule 5 antibody	http://purl.obolibrary.org/obo/HP_5000017		
HP:5000018	biolink:PhenotypicFeature	Anti-ITPR1 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against inositol 1,4,5-trisphosphate receptor 1 (ITPR1).		hp.json	Anti-inositol 1,4,5-trisphosphate receptor type 1 antibody	http://purl.obolibrary.org/obo/HP_5000018		
HP:0032076	biolink:PhenotypicFeature	Abnormal male urethral meatus morphology			hp.json		http://purl.obolibrary.org/obo/HP_0032076		
HP:0032077	biolink:PhenotypicFeature	Male urethral meatus stenosis	An abnormal narrowing of the urethral opening (meatus) of the penis.		hp.json	Meatus stenosis|Meatal stenosis	http://purl.obolibrary.org/obo/HP_0032077		
HP:5000019	biolink:PhenotypicFeature	Anti-Kelch like protein 11 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against kelch-like protein 11 (KLHL11).		hp.json	Anti-KLHL11 antibody	http://purl.obolibrary.org/obo/HP_5000019		
HP:0032078	biolink:PhenotypicFeature	Angel-shaped phalanx	A phalangeal malformation that is termed angel-shaped phalanx (ASP), because of its resemblance to the angels used for decoration of Christmas trees. The various components of an angel-shaped phalanx are: diaphyseal cuff (wings), surrounding a meta-diaphyseal core (body), which may appear empty or structured with a cone-shaped epiphysis (skirt) and pseudoepiphysis (head).		hp.json		http://purl.obolibrary.org/obo/HP_0032078		
GO:2001152	biolink:NamedThing	negative regulation of renal water transport			hp.json		http://purl.obolibrary.org/obo/GO_2001152		
HP:0020082	biolink:PhenotypicFeature	Heinz bodies	A type of erythrocyte inclusion composed of denatured hemoglobin.		hp.json		http://purl.obolibrary.org/obo/HP_0020082		
GO:2001153	biolink:NamedThing	positive regulation of renal water transport			hp.json		http://purl.obolibrary.org/obo/GO_2001153		
HP:0020081	biolink:PhenotypicFeature	Pappenheimer bodies	A type of erythrocyte inclusion characterized by basophilic stippling of erythrocytes, that is, by numerous very small coarse or fine blue granules within the cytoplasm with the additional stipulation that the stippled particles are due to iron granules (demonstrable by the Prussian blue stain).		hp.json		http://purl.obolibrary.org/obo/HP_0020081		
HP:0020084	biolink:PhenotypicFeature	Carbuncle	A pustular lesion of the skin emerging from group of infected hair follicles, characterized by a deep location and dissecting through tissue planes. A carbuncle is larger and deeper than a furuncle.		hp.json		http://purl.obolibrary.org/obo/HP_0020084		
HP:0020083	biolink:PhenotypicFeature	Furuncle	An infection of a hair follicle that extends subcutaneously, forming an abscess.		hp.json	Boil	http://purl.obolibrary.org/obo/HP_0020083		
CL:1000298	biolink:Cell	mesothelial cell of dura mater	A mesothelial cell that is part of the dura mater.	FMA:256516	hp.json	squamous mesothelial cell of dura mater	http://purl.obolibrary.org/obo/CL_1000298		
HP:5000010	biolink:PhenotypicFeature	Anti-GABA(B)R antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against gamma-aminobutyric acid B receptor, i.e., GABA(B)R.		hp.json	Anti-gamma-aminobutyric acid B receptor antibody	http://purl.obolibrary.org/obo/HP_5000010		
HP:0020080	biolink:PhenotypicFeature	Erythrocyte inclusion bodies	Nuclear or cytoplasmic aggregates of substances in red blood cells.		hp.json		http://purl.obolibrary.org/obo/HP_0020080		
HP:5000011	biolink:PhenotypicFeature	Anti-GAD65 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against glutamic acid decarboxylase 65 (GAD65).		hp.json	Anti-glutamic acid decarboxylase 65 antibody	http://purl.obolibrary.org/obo/HP_5000011		
HP:5000012	biolink:PhenotypicFeature	Anti-Gephyrin antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Gephyrin.		hp.json		http://purl.obolibrary.org/obo/HP_5000012		
HP:0020089	biolink:PhenotypicFeature	Post-vaccination rubella	Infection with the rubella virus of the live-attenuated vaccine.		hp.json		http://purl.obolibrary.org/obo/HP_0020089		
HP:0020086	biolink:PhenotypicFeature	BCGitis	Local or regional infection with Bacillus Calmette-Guerin (BCG) following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0020086		
CHEBI:74222	biolink:ChemicalSubstance	gamma-lactam	A lactam in which the amide bond is contained within a five-membered ring, which includes the amide nitrogen and the carbonyl carbon.		hp.json	gamma-lactams	http://purl.obolibrary.org/obo/CHEBI_74222		3_STAR
HP:0020085	biolink:PhenotypicFeature	Infection following live vaccination	An infection resulting from live attenuated vaccines (LAV), that is, a vaccine prepared from living viruses or bacteria that have been weakened under laboratory conditions. LAV vaccines will replicate in a vaccinated individual and produce an immune response but usually cause mild or no disease. are derived from disease-causing pathogens.		hp.json		http://purl.obolibrary.org/obo/HP_0020085		
HP:0020088	biolink:PhenotypicFeature	Post-vaccination measles	Infection with the measles virus of the live-attenuated vaccine. This is an extremely rare event and may indicate immunocompromise in some cases.		hp.json	Vaccine associated measles	http://purl.obolibrary.org/obo/HP_0020088		
HP:0020087	biolink:PhenotypicFeature	BCGosis	Distant, or disseminated infection with Bacillus Calmette-Guerin (BCG) following vaccination associated with failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis.		hp.json	BCGiosis|Disseminated Bacillus Calmette-Guerin infection	http://purl.obolibrary.org/obo/HP_0020087		
CHEBI:74223	biolink:ChemicalSubstance	pyrrolidin-2-ones	A pyrrolidinone in which the oxo group is at position 2 of the pyrrolidine ring.		hp.json	2-pyrrolidones|pyrrolidine-2-ones|2-pyrrolidinones	http://purl.obolibrary.org/obo/CHEBI_74223		3_STAR
GO:2001151	biolink:NamedThing	regulation of renal water transport			hp.json		http://purl.obolibrary.org/obo/GO_2001151		
HP:0032082	biolink:PhenotypicFeature	Translamellar mucoid extracellular matrix accumulation	A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix alters the arrangement of the lamellar units to varying degrees.		hp.json		http://purl.obolibrary.org/obo/HP_0032082		
HP:0032083	biolink:PhenotypicFeature	Aortic elastic fiber fragmentation	Loss and/or fragmentation of elastic fibers of the media of the aorta creating increasingly extended translamellar spaces, with absence of elastic fibers, and increased gaps in elastic fiber lamellae as identified on a stain for elastic fibers.		hp.json	Aortic elastic fibre fragmentation	http://purl.obolibrary.org/obo/HP_0032083		
HP:0032084	biolink:PhenotypicFeature	Aortic elastic fiber thinning	A thinning out of elastic fibers of the media of the aorta that creates widening of intralamellar spaces, as identified on a stain for elastic fibers.		hp.json	Aortic elastic fibre thinning	http://purl.obolibrary.org/obo/HP_0032084		
HP:0032085	biolink:PhenotypicFeature	Aortic elastic fiber disorganization	Nonparallel arrangement/disarray of elastic fibers of the media of the aorta as identified on a stain for elastic fibers.		hp.json	Aortic elastic fibre disorganisation	http://purl.obolibrary.org/obo/HP_0032085		
GO:0050954	biolink:BiologicalProcess	sensory perception of mechanical stimulus	The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.		hp.json	perception of mechanical stimulus|mechanosensory perception|chemi-mechanical coupling	http://purl.obolibrary.org/obo/GO_0050954		
GO:0050953	biolink:BiologicalProcess	sensory perception of light stimulus	The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.		hp.json		http://purl.obolibrary.org/obo/GO_0050953		
HP:0032081	biolink:PhenotypicFeature	Intralamellar mucoid extracellular matrix accumulation	A type of mucoid extracellular matrix accumulation in which the increase in mucoid extracellular matrix does not significantly alter the arrangement of the lamellar units.		hp.json		http://purl.obolibrary.org/obo/HP_0032081		
HP:5000024	biolink:PhenotypicFeature	Anti-mGluR1 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against metabotropic glutamate receptor 1 (mGluR1).		hp.json	Anti-metabotropic glutamate receptor 1 antibody	http://purl.obolibrary.org/obo/HP_5000024		
HP:5000025	biolink:PhenotypicFeature	Anti-mGluR5 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against metabotropic glutamate receptor 5 (mGluR5).		hp.json	Anti-Metabotropic Glutamate Receptor Type 5 antibody	http://purl.obolibrary.org/obo/HP_5000025		
HP:5000026	biolink:PhenotypicFeature	Anti-neurexin-3alpha antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against neurexin-3alpha.		hp.json	Anti-neurexin-3alpha antibody	http://purl.obolibrary.org/obo/HP_5000026		
GO:0050957	biolink:BiologicalProcess	equilibrioception	The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion.	Wikipedia:Equilibrioception	hp.json	sensory perception of orientation with respect to gravity	http://purl.obolibrary.org/obo/GO_0050957		
HP:5000027	biolink:PhenotypicFeature	Anti-P/Q-type VGCC antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against P/Q-type voltage-gated calcium channels (VGCCs).		hp.json	Anti-P/Q-type voltage-gated calcium-channel antibody	http://purl.obolibrary.org/obo/HP_5000027		
HP:0032086	biolink:PhenotypicFeature	Aortic smooth muscle cell nuclei loss	A region of the aortic media in which smooth muscle cell nuclei, involving multiple lamellae, are not clearly identifiable on an hematoxylin and eosin stain.		hp.json		http://purl.obolibrary.org/obo/HP_0032086		
HP:5000028	biolink:PhenotypicFeature	Anti-MAP1B antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against microtubule-associated protein 1B (MAP1B).		hp.json	Anti-Purkinje cell cytoplasmic type-2 antibody|Anti-microtubule-associated protein 1B antibody	http://purl.obolibrary.org/obo/HP_5000028		
HP:0032087	biolink:PhenotypicFeature	Aortic laminar medial collapse	Architecturally, a compaction of aortic medial elastic fibers that creates thinning of the lamellar unit secondary to a band-like smooth muscle cell loss identified using a stain for elastic fibers.		hp.json		http://purl.obolibrary.org/obo/HP_0032087		
HP:5000029	biolink:PhenotypicFeature	Anti-PKCgamma antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against protein kinase Cgamma.		hp.json	Anti-Protein kinase C gamma antibody	http://purl.obolibrary.org/obo/HP_5000029		
HP:0032088	biolink:PhenotypicFeature	Aortic smooth muscle cell disorganization	Nonparallel arrangement/disarray of smooth muscle cells of the aortic media creating focal/multifocal disarray or sometimes nodular aggregates of smooth muscle cells.		hp.json	Aortic smooth muscle cell disorganisation	http://purl.obolibrary.org/obo/HP_0032088		
HP:0032089	biolink:PhenotypicFeature	Aortic medial fibrosis	An increase in collagen fibers creating areas of substitutive fibrosis or a widening of intralamellar spaces in the media of the aorta. This can be seen in conjunction with a loss to varying degrees of parallel arrangement of the elastic lamellae (or lamellar units).		hp.json		http://purl.obolibrary.org/obo/HP_0032089		
HP:0020071	biolink:PhenotypicFeature	Viremia	The presence of virus in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0020071		
HP:0020073	biolink:PhenotypicFeature	Hypopigmented macule	A white or lighter patch of skin that may appear anywhere on the body and are caused by decreased skin pigmentation.		hp.json		http://purl.obolibrary.org/obo/HP_0020073		
HP:0020072	biolink:PhenotypicFeature	Persistent EBV viremia	Persistent presence of Epstein-Barr virus in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0020072		
CL:1000286	biolink:Cell	smooth muscle cell of rectum	A smooth muscle cell that is part of the rectum.	FMA:17522	hp.json	non-striated muscle fiber of rectum|smooth muscle fiber of rectum	http://purl.obolibrary.org/obo/CL_1000286		
HP:5000020	biolink:PhenotypicFeature	Anti-LGI1 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against leucine-rich glioma-inactivated 1 (LGI1).		hp.json	Anti-Anti-leucine-rich glioma-inactivated 1 antibody	http://purl.obolibrary.org/obo/HP_5000020		
HP:5000021	biolink:PhenotypicFeature	Anti-Ma antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma.		hp.json		http://purl.obolibrary.org/obo/HP_5000021		
CL:1000285	biolink:Cell	smooth muscle cell of sigmoid colon	A smooth muscle cell that is part of the sigmoid colon.	FMA:17521	hp.json	non-striated muscle fiber of sigmoid colon	http://purl.obolibrary.org/obo/CL_1000285		
HP:5000022	biolink:PhenotypicFeature	Anti-Ma2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma2.		hp.json	Anti-Ta antibody	http://purl.obolibrary.org/obo/HP_5000022		
HP:5000023	biolink:PhenotypicFeature	Anti-Ma1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ma1.		hp.json		http://purl.obolibrary.org/obo/HP_5000023		
HP:0020079	biolink:PhenotypicFeature	Beta-alaninuria	An increased level of beta-alanine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020079		
HP:0020078	biolink:PhenotypicFeature	Alaninuria	An increased level of alanine in the urine.		hp.json	Increased urinary alanine	http://purl.obolibrary.org/obo/HP_0020078		
CL:1000280	biolink:Cell	smooth muscle cell of colon	A smooth muscle cell that is part of the colon.	FMA:15663	hp.json	non-striated muscle fiber of colon	http://purl.obolibrary.org/obo/CL_1000280		
HP:0020075	biolink:PhenotypicFeature	Leucine crystalluria	The presence of leuucine crystals in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020075		
HP:0020074	biolink:PhenotypicFeature	Crystalluria	The presence of crystals in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020074		
HP:0020077	biolink:PhenotypicFeature	Carnitinuria	An elevated level of carnitine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0020077		
HP:0020076	biolink:PhenotypicFeature	Wrist ganglion	A benign soft tissue tumor of the wrist usually found in the dorsal aspect of the wrist and communicate with the joint via a pedicle. This pedicle usually originates not only at the scapholunate ligament, but also may arise from a number of other sites over the dorsal aspect of the wrist capsule.		hp.json	Ganglion cyst of the wrist	http://purl.obolibrary.org/obo/HP_0020076		
GO:0050962	biolink:BiologicalProcess	detection of light stimulus involved in sensory perception	The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light.		hp.json	sensory transduction of light stimulus|sensory perception, sensory detection of light stimulus|sensory detection of light stimulus during sensory perception|sensory perception, sensory transduction of light stimulus|sensory detection of light stimulus|sensory transduction of light stimulus during sensory perception	http://purl.obolibrary.org/obo/GO_0050962		
HP:0032094	biolink:PhenotypicFeature	Increased circulating surfactant protein level	An increased concentration of a surfactant protein in the blood circulation. Pulmonary surfactant is a highly surface-active mixture of proteins and lipids that is synthesized and secreted onto the alveoli by type II epithelial cells. The protein part of surfactant constitutes of four types of surfactant proteins (SP), SP-A, SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic proteins that regulate surfactant metabolism and have immunologic functions. These two proteins are detectable in the bloodstream and an elevated level may reflect idiopathic pulmonary fibrosis.		hp.json	Increased serum surfactant protein level	http://purl.obolibrary.org/obo/HP_0032094		
HP:0007095	biolink:PhenotypicFeature	obsolete Frontoparietal polymicrogyria			hp.json		http://purl.obolibrary.org/obo/HP_0007095		
HP:0032096	biolink:PhenotypicFeature	Abnormal manganese concentration	A deviation from the normal range of manganese in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0032096		
HP:0007096	biolink:PhenotypicFeature	Hypoplasia of the optic tract		UMLS:C1856654	hp.json	Underdeveloped optic tract	http://purl.obolibrary.org/obo/HP_0007096		
HP:0032090	biolink:PhenotypicFeature	Intralamellar aortic medial fibrosis	A type of aortic medial fibrosis in which the increase in collagen does not significantly alter the arrangement of the lamellar units.		hp.json		http://purl.obolibrary.org/obo/HP_0032090		
HP:0032091	biolink:PhenotypicFeature	Translamellar aortic medial fibrosis	A type of aortic medial fibrosis in which the increase in collagen is more scar-like, altering the arrangement of the lamellar units.		hp.json		http://purl.obolibrary.org/obo/HP_0032091		
HP:0032092	biolink:PhenotypicFeature	Left ventricular outflow tract obstruction	Left ventricular outflow tract (LVOT) obstruction can occur at the valvular, subvalvular, or supravalvular level. In general, there is an obstruction to forward flow which increases afterload, and if untreated, can result in hypertrophy, dilatation, and eventual failure of the left ventricle.		hp.json		http://purl.obolibrary.org/obo/HP_0032092		
HP:0032097	biolink:PhenotypicFeature	Hypermanganesemia	An elevation above the normal concentration of manganese in the blood.		hp.json	Increased blood manganese concentration	http://purl.obolibrary.org/obo/HP_0032097		
HP:0032098	biolink:PhenotypicFeature	Hypomanganesemia	A reduction below the normal concentration of manganese in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0032098		
HP:0032099	biolink:PhenotypicFeature	Perioral radial furrowing	The presence of radial grooves in the skin surrounding the mouth (see Figure 4 of PMID:27833976).		hp.json		http://purl.obolibrary.org/obo/HP_0032099		
CL:0002485	biolink:Cell	retinal melanocyte	A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium.		hp.json		http://purl.obolibrary.org/obo/CL_0002485		
HP:0020060	biolink:PhenotypicFeature	Decreased red blood cell count	An abnormal reduction below the normal number of red blood cells per volume in the circulation.		hp.json	Decreased RBC count	http://purl.obolibrary.org/obo/HP_0020060		
CL:0002484	biolink:Cell	epithelial melanocyte	A melanocyte that produces pigment in the epithelium.		hp.json		http://purl.obolibrary.org/obo/CL_0002484		
HP:0020062	biolink:PhenotypicFeature	Decreased hemoglobin concentration	An abnormal reduction below normal hemoglobin concentration in the circulation.		hp.json	Decreased haemoglobin concentration|Decreased Hb concentration	http://purl.obolibrary.org/obo/HP_0020062		
HP:0020061	biolink:PhenotypicFeature	Abnormal hemoglobin concentration	Any deviation from the normal concentration of hemoglobin in the blood.		hp.json	Abnormal haemoglobin concentration|Abnormal Hb concentration	http://purl.obolibrary.org/obo/HP_0020061		
CL:0002489	biolink:Cell	double negative thymocyte	A thymocyte that lacks expression of CD4 and CD8.		hp.json	CD4-CD8- T cell|double negative T cell	http://purl.obolibrary.org/obo/CL_0002489		
HP:0007086	biolink:PhenotypicFeature	Social and occupational deterioration		UMLS:C1866986	hp.json		http://purl.obolibrary.org/obo/HP_0007086		
HP:0020064	biolink:PhenotypicFeature	Abnormal eosinophil count	Any deviation from the normal number of eosinophils per volume in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0020064		
HP:0007087	biolink:PhenotypicFeature	obsolete Involuntary jerking movements			hp.json		http://purl.obolibrary.org/obo/HP_0007087		
HP:0020063	biolink:PhenotypicFeature	Increased hemoglobin concentration	An abnormal elevation above normal hemoglobin concentration in the circulation.		hp.json	Increased Hb concentration|Increased haemoglobin concentration	http://purl.obolibrary.org/obo/HP_0020063		
HP:0007089	biolink:PhenotypicFeature	Facial-lingual fasciculations	Fasciculations affecting the tongue muscle and the musculature of the face.	UMLS:C1862359	hp.json		http://purl.obolibrary.org/obo/HP_0007089		
CL:0002482	biolink:Cell	dermal melanocyte	A melanocyte that produces pigment in the dermis.		hp.json		http://purl.obolibrary.org/obo/CL_0002482		
GO:0050973	biolink:BiologicalProcess	detection of mechanical stimulus involved in equilibrioception	The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears.		hp.json	sensory detection of mechanical stimulus during equilibrioception|equilibrioception, sensory detection of mechanical stimulus|equilibrioception, detection of mechanical stimulus|equilibrioception, sensory transduction of mechanical stimulus|sensory transduction of mechanical stimulus during equilibrioception	http://purl.obolibrary.org/obo/GO_0050973		
GO:0050974	biolink:BiologicalProcess	detection of mechanical stimulus involved in sensory perception	The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception.		hp.json	sensory perception, sensory transduction of mechanical stimulus|sensory perception, sensory detection of mechanical stimulus|sensory transduction of mechanical stimulus during sensory perception|sensory detection of mechanical stimulus during sensory perception|sensory transduction of mechanical stimulus|sensory detection of mechanical stimulus	http://purl.obolibrary.org/obo/GO_0050974		
HP:5000002	biolink:PhenotypicFeature	Anti-Amphiphysin antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Amphiphysin.		hp.json		http://purl.obolibrary.org/obo/HP_5000002		
HP:5000003	biolink:PhenotypicFeature	Anti-ARHGAP26 antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Rho GTPase-activating protein 26 (ARHGAP26).		hp.json	Anti-Ca antibody|Anti-RhoGTPase-activating protein 26 antibody	http://purl.obolibrary.org/obo/HP_5000003		
UBERON:0012375	biolink:AnatomicalEntity	subserosa	A layer of tissue between the muscularis and serosa.	SCTID:2255006|NCIT:C94494|Wikipedia:Subserosa|FMA:45636|UMLS:C0225334	hp.json		http://purl.obolibrary.org/obo/UBERON_0012375		human_reference_atlas
HP:5000004	biolink:PhenotypicFeature	Anti-CARP VIII antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Carbonic anhydrase-related protein VIII (CARPVIII).		hp.json	Anti-carbonic anhydrase-related protein VIII antibody|Anti CARPVIII antibody	http://purl.obolibrary.org/obo/HP_5000004		
HP:5000005	biolink:PhenotypicFeature	Anti-CASPR2	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against contactin-associated protein-like 2 (CASPR2).		hp.json	Anti-contactin-associated protein-like 2 antibody|Anti-Caspr2 antibody	http://purl.obolibrary.org/obo/HP_5000005		
UBERON:0012373	biolink:AnatomicalEntity	sympathetic nerve plexus	A nerve plexus that is part of a sympathetic nervous system.	MA:0001160|EMAPA:37617	hp.json		http://purl.obolibrary.org/obo/UBERON_0012373		human_reference_atlas
HP:5000006	biolink:PhenotypicFeature	Anti-CV2/CRMP5 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CV2/CRMP5. Anti-CV2/CRMP5 autoantibody is the most commonly detected anti-neuronal autoantibody. Patients with typical paraneoplastic chorea show fully developed chorea in the course of weeks to months with acute inflammation in the striatum.		hp.json	Anti-CV2/collapsin response mediator protein (CRMP)5 antibody|Anti-CV2 antibody|Anti-collapsin response-mediated protein 5 antibody	http://purl.obolibrary.org/obo/HP_5000006		
HP:5000007	biolink:PhenotypicFeature	Anti-DPPX antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against dipeptidyl-peptidase-like protein 6 (DPPX).		hp.json	Anti-dipeptidyl-peptidase-like protein 6 antibody	http://purl.obolibrary.org/obo/HP_5000007		
UBERON:0012378	biolink:AnatomicalEntity	muscle layer of urinary bladder	A muscular coat that is part of a urinary bladder.	FMA:15930|UMLS:C1288327|NCIT:C32206	hp.json	muscle layer of urinary bladder|tunica muscularis (vesica urinaria)|muscular coat of bladder|tunica musculari vesicae|muscular layer of bladder|bladder muscular coat|muscular coat of urinary bladder|muscular layer of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0012378		human_reference_atlas
HP:5000008	biolink:PhenotypicFeature	Anti-FGFR3 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against FGFR3.		hp.json	Anti-fibroblast growth factor receptor 3 antibody	http://purl.obolibrary.org/obo/HP_5000008		
UBERON:0012377	biolink:AnatomicalEntity	muscle layer of jejunum	A muscular coat that is part of a jejunum.	FMA:14951	hp.json	muscularis externa of jejunum|jejunal smooth muscle|muscularis propria of jejunum|smooth muscle of jejunum	http://purl.obolibrary.org/obo/UBERON_0012377		human_reference_atlas
HP:5000009	biolink:PhenotypicFeature	Anti-GABA(A)R antibody	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against gamma-aminobutyric acid A receptor, i.e., GABA(A)R.		hp.json	Anti-GABAA R antibody|Anti-gamma amino butyric acid type A receptors antibody	http://purl.obolibrary.org/obo/HP_5000009		
UBERON:0000390	biolink:AnatomicalEntity	lens nucleus	The core of the crystalline lens, surrounded by the cortex.	BTO:0001633|FMA:58971|MESH:D007907|MESH:A09.371.509.670|SCTID:280628007	hp.json	nucleus of lens	http://purl.obolibrary.org/obo/UBERON_0000390		human_reference_atlas
UBERON:0000391	biolink:AnatomicalEntity	leptomeninx	Pia mater or arachnoid mater.	FMA:231515|BTO:0001634|CALOHA:TS-0546|NCIT:C32979|NLXANAT:090207|UMLS:C0228126	hp.json	pia-arachnoid|leptomeninges|arachnoidea mater et pia mater|pia-arachnoid of neuraxis|arachnoid mater and pia mater	http://purl.obolibrary.org/obo/UBERON_0000391		organ_slim
HP:0020050	biolink:PhenotypicFeature	Anti-granulocyte-macrophage colony stimulating factor antibody positivity	The presence of autoantibodies in the serum that react against granulocyte-macrophage colony stimulating factor.		hp.json	Anti-GM-CSF antibody positivity	http://purl.obolibrary.org/obo/HP_0020050		
HP:5000000	biolink:PhenotypicFeature	Anti-AK5 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-adenylate kinase 5 (AK5).		hp.json		http://purl.obolibrary.org/obo/HP_5000000		
HP:5000001	biolink:PhenotypicFeature	Anti-AMPAR antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR).		hp.json	Anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibody	http://purl.obolibrary.org/obo/HP_5000001		
UBERON:0000398	biolink:AnatomicalEntity	cartilage tissue of sternum	Any portion of cartilage tissue that is part of the sternum.	FMA:32567	hp.json	cartilage of sternum	http://purl.obolibrary.org/obo/UBERON_0000398		
UBERON:0000399	biolink:AnatomicalEntity	jejunal mucosa	A mucosa that is part of a jejunum [Automatically generated definition].	MA:0003214|FMA:14949|BTO:0001742|EMAPA:27109|CALOHA:TS-0495	hp.json	mucosa of jejunum|jejunal mucous membrane|jejunum mucosa|jejunum mucosa of organ|mucous membrane of jejunum|organ mucosa of jejunum|jejunum mucous membrane|jejunum organ mucosa|mucosa of organ of jejunum	http://purl.obolibrary.org/obo/UBERON_0000399		human_reference_atlas
HP:0020059	biolink:PhenotypicFeature	Increased red blood cell count	An abnormal elevation above the normal number of red blood cells per volume in the circulation.		hp.json	Increased RBC count	http://purl.obolibrary.org/obo/HP_0020059		
HP:0020058	biolink:PhenotypicFeature	Abnormal red blood cell count	Any deviation from the normal number of red blood cells per volume in the circulation.		hp.json	Abnormal RBC count	http://purl.obolibrary.org/obo/HP_0020058		
HP:0007097	biolink:PhenotypicFeature	Cranial nerve motor loss		UMLS:C4024940	hp.json		http://purl.obolibrary.org/obo/HP_0007097		
HP:0007098	biolink:PhenotypicFeature	Paroxysmal choreoathetosis	Episodes of choreoathetosis that can occur following triggers such as quick voluntary movements.	UMLS:C1851936|SNOMEDCT_US:49949003	hp.json	Choreoathetosis, episodic|Choreoathetosis, intermittent	http://purl.obolibrary.org/obo/HP_0007098		
UBERON:0000395	biolink:AnatomicalEntity	cochlear ganglion	The group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)[MP]. distributed to the hair cells of the spiral organ. The cochlear fibers arise in bipolar cells in the spiral ganglion in the modiolus.	VHOG:0001183|EMAPA:17572|MESH:D013136|BTO:0001688|FMA:53445|MA:0001085|EHDAA2:0002198|BAMS:GcVIII|GAID:722	hp.json	cochlear part of vestibulocochlear ganglion|ganglion cochlearis|spiral ganglion|vestibulocochlear ganglion cochlear component|spiral ganglion of cochlea|Corti's ganglion|ganglion spirale|ganglion spirale cochleae|vestibulocochlear VIII ganglion cochlear component|ganglion of Corti	http://purl.obolibrary.org/obo/UBERON_0000395		pheno_slim
HP:0007099	biolink:PhenotypicFeature	Chiari type I malformation	Arnold-Chiari type I malformation refers to a relatively mild degree of herniation of the posteroinferior region of the cerebellum (the cerebellar tonsils) into the cervical canal with little or no displacement of the fourth ventricle. It is characterized by one or both pointed (not rounded) cerebellar tonsils that project 5 mm below the foramen magnum, measured by a line drawn from the basion to the opisthion (McRae Line)	UMLS:C0750929|MSH:D001139|SNOMEDCT_US:253185002	hp.json	Arnold Chiari type I malformation|Arnold-Chiari type I malformation|Chiari I malformation	http://purl.obolibrary.org/obo/HP_0007099		
CL:0002494	biolink:Cell	cardiocyte	A cell located in the heart, including both muscle and non muscle cells.	CALOHA:TS-0115|FMA:84791|BTO:0001539|FMA:83808	hp.json	heart cell	http://purl.obolibrary.org/obo/CL_0002494		
UBERON:0000397	biolink:AnatomicalEntity	colonic epithelium	An epithelium that is part of a colon [Automatically generated definition].	CALOHA:TS-0163|TAO:0005128|MA:0003195|SCTID:42978003|BTO:0001709|FMA:17302|EMAPA:18941|ZFA:0005128	hp.json	epithelial tissue of colon|large bowel epithelium|epithelium of large bowel|colon epithelium|colon epithelial tissue|epithelial tissue of large bowel|colon epithelium|large bowel epithelial tissue|posterior intestine epithelium|epithelium of colon	http://purl.obolibrary.org/obo/UBERON_0000397		human_reference_atlas|vertebrate_core
HP:0020054	biolink:PhenotypicFeature	Abnormal erythrocyte physiology	Any functional abnormality of erythrocytes (red-blood cells).		hp.json		http://purl.obolibrary.org/obo/HP_0020054		
HP:0032030	biolink:PhenotypicFeature	Lateral canthal tendon laxity	Laxity of the tendon stabilising the lateral aspect of the tarsal plate to the zygomatic bone. This can result in rounded appearence of the lateral canthus. Also, when the eyelid is pulled medially, more than 2 mm movement of the canthal angle may be observed.		hp.json		http://purl.obolibrary.org/obo/HP_0032030		
GO:0050982	biolink:BiologicalProcess	detection of mechanical stimulus	The series of events by which a mechanical stimulus is received and converted into a molecular signal.		hp.json		http://purl.obolibrary.org/obo/GO_0050982		
HP:0032035	biolink:PhenotypicFeature	Lower eyelid laxity	Abnormally lax lower eyelid associated with tissue relaxation.		hp.json		http://purl.obolibrary.org/obo/HP_0032035		
HP:0032036	biolink:PhenotypicFeature	Reduced contrast sensitivity	An abnormality in perception of contrast. Spatial contrast is a physical dimension referring to the light-dark transition of a border or an edge in an image that delineates the existence of a pattern or an object. Contrast sensitivity refers to a measure of how much contrast a person requires to see a target. Contrast-sensitivity measurements differ from acuity measurements; acuity is a measure of the spatial-resolving ability of the visual system under conditions of very high contrast, whereas contrast sensitivity is a measure of the threshold contrast for seeing a target.		hp.json	Abnormal contrast sensitivity	http://purl.obolibrary.org/obo/HP_0032036		
HP:0032037	biolink:PhenotypicFeature	Mildly reduced visual acuity	Mild reduction of the ability to see defined as visual acuity less than 6/12 (20/40 in US notation; 0.5 in decimal notation) but at least 6/18 (20/63 in US notation; 0.32 in decimal notation).		hp.json	Mild visual loss|Mild vision loss|Mild reduction in visual acuity	http://purl.obolibrary.org/obo/HP_0032037		
HP:0032031	biolink:PhenotypicFeature	Medial canthal tendon laxity	Laxity of the tendon stabilising the medial aspect of the tarsal plate to the anterior and posterior lacrimal crests. This may lead to more than 2mm movement of the punctum when the eyelid is pulled laterally.		hp.json		http://purl.obolibrary.org/obo/HP_0032031		
HP:0032032	biolink:PhenotypicFeature	Horizontal eyelid laxity	Abnormally lax eyelid associated with tissue relaxation, predominantly in the horizontal plane. It can be demonstrated by the horizontal eyelid distraction test (e.g. by pulling the eyelid medially and laterally). Medial and/or lateral canthal tendon laxity are often present.		hp.json		http://purl.obolibrary.org/obo/HP_0032032		
HP:0032033	biolink:PhenotypicFeature	Vertical eyelid laxity	Abnormally lax eyelid associated with tissue relaxation, predominantly in the vertical plane. It can be demonstrated by vertical lid pull. Loosening of vertical stabilising structures (e.g. lower lid retractors) or tarsal atrophy are often present.		hp.json		http://purl.obolibrary.org/obo/HP_0032033		
HP:0032034	biolink:PhenotypicFeature	Upper eyelid laxity	Abnormally lax upper eyelid associated with tissue relaxation.		hp.json		http://purl.obolibrary.org/obo/HP_0032034		
UBERON:0036328	biolink:AnatomicalEntity	wall of coronary artery		FMA:14179	hp.json	coronary arterial wall	http://purl.obolibrary.org/obo/UBERON_0036328		
CL:0002465	biolink:Cell	CD11b-positive dendritic cell	A conventional dendritic cell that expresses CD11b (ITGAM).		hp.json		http://purl.obolibrary.org/obo/CL_0002465		
HP:0032039	biolink:PhenotypicFeature	Abnormality of the ocular adnexa	An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.		hp.json		http://purl.obolibrary.org/obo/HP_0032039		
GO:0098928	biolink:BiologicalProcess	presynaptic signal transduction	Signal transduction in which the initial step occurs in a presynapse.		hp.json	presynaptic signaling pathway	http://purl.obolibrary.org/obo/GO_0098928		goslim_synapse|gocheck_do_not_manually_annotate
GO:0098926	biolink:BiologicalProcess	postsynaptic signal transduction	Signal transduction in which the initial step occurs in a postsynapse.		hp.json	postsynaptic signaling pathway	http://purl.obolibrary.org/obo/GO_0098926		goslim_synapse|gocheck_do_not_manually_annotate
GO:0098920	biolink:BiologicalProcess	retrograde trans-synaptic signaling by lipid	Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand.		hp.json		http://purl.obolibrary.org/obo/GO_0098920		goslim_synapse
GO:0106122	biolink:BiologicalProcess	negative regulation of cobalamin metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of a cobalamin metabolic process.		hp.json		http://purl.obolibrary.org/obo/GO_0106122		
GO:0106121	biolink:BiologicalProcess	positive regulation of cobalamin metabolic process	Any process that activates or increases the frequency, rate or extent of a cobalamin metabolic process.		hp.json		http://purl.obolibrary.org/obo/GO_0106121		
HP:0032040	biolink:PhenotypicFeature	Abnormal ocular adnexa physiology	A functional anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva.		hp.json		http://purl.obolibrary.org/obo/HP_0032040		
HP:0032041	biolink:PhenotypicFeature	Vocal cord polyp	A small growth on a vocal cord that may appear as pedunculated or sessile and have varying size, shape, and color.		hp.json		http://purl.obolibrary.org/obo/HP_0032041		
HP:0032046	biolink:PhenotypicFeature	Focal cortical dysplasia	A type of malformation of cortical development that primarily affects areas of neocortex. It can be identified on conventional magnetic resonance imaging as focal cortical thickening, abnormal gyration, and blurring between gray and white matter, often associated with clusters of heterotopic neurons.		hp.json		http://purl.obolibrary.org/obo/HP_0032046		
UBERON:0036343	biolink:AnatomicalEntity	wall of gallbladder		FMA:14657	hp.json	gallbladder wall	http://purl.obolibrary.org/obo/UBERON_0036343		
HP:0032047	biolink:PhenotypicFeature	Focal cortical dysplasia type I	A type of focal cortical dysplasia that is characterized by abnormal cortical layering.		hp.json		http://purl.obolibrary.org/obo/HP_0032047		
HP:0032048	biolink:PhenotypicFeature	Focal cortical dysplasia type Ia	A subtype of focal cortical dysplasia type I that is characterized by abnormal radial cortical lamination.		hp.json		http://purl.obolibrary.org/obo/HP_0032048		
HP:0032049	biolink:PhenotypicFeature	Focal cortical dysplasia type Ib	A subtype of focal cortical dysplasia type I that is characterized by abnormal tangential cortical lamination.		hp.json		http://purl.obolibrary.org/obo/HP_0032049		
HP:0032043	biolink:PhenotypicFeature	Odynophagia	Pain experienced with swallowing.		hp.json	Painful swallowing	http://purl.obolibrary.org/obo/HP_0032043		
HP:0032044	biolink:PhenotypicFeature	Decreased vigilance	A reduction in the ability to maintain sustained attention characterized by reduced alertness.		hp.json		http://purl.obolibrary.org/obo/HP_0032044		
HP:0032045	biolink:PhenotypicFeature	Hypoplastic carotid canal	Underdevelopment of the carotid canal, which normally is a circular aperture in the temporal bone of the skull through which the internal carotid artery and the carotid plexus of nerves traverse.		hp.json		http://purl.obolibrary.org/obo/HP_0032045		
GO:0098930	biolink:BiologicalProcess	axonal transport	The directed movement of organelles or molecules along microtubules in axons.	Wikipedia:Axoplasmic_transport	hp.json	axon cargo transport|axoplasmic transport	http://purl.obolibrary.org/obo/GO_0098930		goslim_synapse
HP:0032050	biolink:PhenotypicFeature	Focal cortical dysplasia type Ic	A subtype of focal cortical dysplasia type I that is characterized by abnormal radial and tangential cortical lamination.		hp.json		http://purl.obolibrary.org/obo/HP_0032050		
HP:0032051	biolink:PhenotypicFeature	Focal cortical dysplasia type II	A type of focal cortical dysplasia that is characterized by disrupted cortical lamination and specific cytological abnormalities.		hp.json		http://purl.obolibrary.org/obo/HP_0032051		
HP:0032052	biolink:PhenotypicFeature	Focal cortical dysplasia type IIa	A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons, which present with a significantly enlarged cell body and nucleus, malorientation, abnormally distributed intracellular Nissl substance and cytoplasmic accumulation of neurofilament proteins.		hp.json		http://purl.obolibrary.org/obo/HP_0032052		
UBERON:0036352	biolink:AnatomicalEntity	wall of subclavian artery		FMA:15090	hp.json	subclavian arterial wall	http://purl.obolibrary.org/obo/UBERON_0036352		
UBERON:0036351	biolink:AnatomicalEntity	wall of brachiocephalic artery		FMA:15089	hp.json	brachiocephalic arterial wall	http://purl.obolibrary.org/obo/UBERON_0036351		
GO:1902513	biolink:BiologicalProcess	regulation of organelle transport along microtubule	Any process that modulates the frequency, rate or extent of organelle transport along microtubule.		hp.json	regulation of microtubule-based organelle localization	http://purl.obolibrary.org/obo/GO_1902513		
HP:0032057	biolink:PhenotypicFeature	Focal cortical dysplasia type IIIc	A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural (cortical dyslamination, hypoplasia) or cytoarchitectural composition of the neocortex (hypertrophic neurons), which occur adjacent to vascular malformations (cavernomas, arteriovenous malformations, leptomeningeal vascular malformations, telangiectasias, meningioangiomatosis).		hp.json		http://purl.obolibrary.org/obo/HP_0032057		
HP:0032058	biolink:PhenotypicFeature	Focal cortical dysplasia type IIId	A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to other lesions acquired during early life (not included into FCD Type IIIa-c). These lesions comprise a large spectrum including traumatic brain injury, glial scarring after prenatal or perinatal ischemic injury or bleeding, and inflammatory or infectious diseases, i.e. Rasmussen encephalitis, limbic encephalitis, bacterial or viral infections.		hp.json		http://purl.obolibrary.org/obo/HP_0032058		
HP:0032059	biolink:PhenotypicFeature	Mild malformation of cortical development	A malformation of cortical development characterized by mild abnormalities of the cortex: excessive heterotopic neurons in Layer 1 or microscopic neuronal clusters or excess of single neurons of normal morphology in deep white matter.		hp.json		http://purl.obolibrary.org/obo/HP_0032059		
CHEBI:15904	biolink:ChemicalSubstance	long-chain fatty acid	A fatty acid with a chain length ranging from C13 to C22.	KEGG:C00638	hp.json	Long-chain fatty acid|Higher fatty acid|long-chain fatty acids|LCFA|LCFAs	http://purl.obolibrary.org/obo/CHEBI_15904		3_STAR
HP:0032053	biolink:PhenotypicFeature	Focal cortical dysplasia type IIb	A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons (significantly enlarged with accumulation of neurofilament proteins) and balloon cells.		hp.json		http://purl.obolibrary.org/obo/HP_0032053		
CHEBI:15903	biolink:ChemicalSubstance	beta-D-glucose	D-Glucopyranose with beta configuration at the anomeric centre.	PMID:31537530|Drug_Central:845|GlyTouCan:G71142DF|PMID:19443021|GlyGen:G71142DF|KEGG:C00221|CAS:492-61-5|Reaxys:1281607|Beilstein:1281607|PMID:25568069|PDBeChem:BGC|DrugBank:DB02379|CAS:492-61-5|Gmelin:648637|CAS:492-61-5	hp.json	BETA-D-GLUCOSE|beta-D-glucose|WURCS=2.0/1,1,0/[a2122h-1b_1-5]/1/|beta-D-Glucose|beta-D-glucopyranose	http://purl.obolibrary.org/obo/CHEBI_15903		3_STAR
PR:000009054	biolink:Protein	insulin gene translation product	An insulin family protein that is a translation product of the human INS gene or a 1:1 ortholog thereof.		hp.json	INS|insulin	http://purl.obolibrary.org/obo/PR_000009054		
HP:0032054	biolink:PhenotypicFeature	Focal cortical dysplasia type III	A type of focal cortical dysplasia that is characterized by cortical lamination abnormalities associated with a principal lesion, usually adjacent to or affecting the same cortical area/lobe.		hp.json		http://purl.obolibrary.org/obo/HP_0032054		
HP:0032055	biolink:PhenotypicFeature	Focal cortical dysplasia type IIIa	A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural organisation (cortical dyslamination) or cytoarchitectural composition (hypertrophic neurons outside Layer 5) in patients with hippocampal sclerosis (also known as Ammon's horn sclerosis).		hp.json		http://purl.obolibrary.org/obo/HP_0032055		
HP:0032056	biolink:PhenotypicFeature	Focal cortical dysplasia type IIIb	A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) and/or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to glial or glioneuronal tumor.		hp.json		http://purl.obolibrary.org/obo/HP_0032056		
CL:1000279	biolink:Cell	smooth muscle cell of large intestine	A smooth muscle cell that is part of the large intestine.	FMA:15653	hp.json	non-striated muscle fiber of large intestine	http://purl.obolibrary.org/obo/CL_1000279		
GO:0098907	biolink:BiologicalProcess	regulation of SA node cell action potential	Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.		hp.json	regulation of sinus node cardiac muscle cell action potential|regulation of SAN cardiac muscle cell action potential|regulation of SA node cardiac muscle cell action potential|regulation of sinoatrial node cardiac muscle cell action potential	http://purl.obolibrary.org/obo/GO_0098907		
GO:0098908	biolink:BiologicalProcess	regulation of neuronal action potential	Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a neuron. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.		hp.json	generation of action potential	http://purl.obolibrary.org/obo/GO_0098908		
CL:1000274	biolink:Cell	trophectodermal cell			hp.json	trophectoderm cell	http://purl.obolibrary.org/obo/CL_1000274		
GO:0098906	biolink:BiologicalProcess	regulation of Purkinje myocyte action potential	Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.		hp.json		http://purl.obolibrary.org/obo/GO_0098906		
CL:1000272	biolink:Cell	lung secretory cell			hp.json		http://purl.obolibrary.org/obo/CL_1000272		
CL:1000271	biolink:Cell	lung ciliated cell			hp.json		http://purl.obolibrary.org/obo/CL_1000271		
GO:0098904	biolink:BiologicalProcess	regulation of AV node cell action potential	Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.		hp.json	regulation of AV node cardiac muscle cell action potential|regulation of atrioventricular node cardiac muscle cell action potential	http://purl.obolibrary.org/obo/GO_0098904		
GO:0098901	biolink:BiologicalProcess	regulation of cardiac muscle cell action potential	Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.		hp.json		http://purl.obolibrary.org/obo/GO_0098901		
GO:0098900	biolink:BiologicalProcess	regulation of action potential	Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.		hp.json		http://purl.obolibrary.org/obo/GO_0098900		
HP:0032060	biolink:PhenotypicFeature	Epithelioid hemangioma	A benign neoplasm that includes blood vessel proliferation and a dense eosinophilic inflammatory infiltrate, manifesting as flesh/plum-colored pruritic nodules and papules, most commonly affecting the ear and the periauricular area.		hp.json	Angiolymphoid hyperplasia with eosinophilia	http://purl.obolibrary.org/obo/HP_0032060		
HP:0032061	biolink:PhenotypicFeature	Hypereosinophilia	A severely increased count of eosinophils in the blood defined as a blood eosinophil count of at least 1.5 billion cells per liter.		hp.json		http://purl.obolibrary.org/obo/HP_0032061		
HP:0032062	biolink:PhenotypicFeature	Mallory-Weiss tear	Vomiting-induced mucosal laceration at the esophago-gastric junction.		hp.json		http://purl.obolibrary.org/obo/HP_0032062		
HP:0032063	biolink:PhenotypicFeature	Ankle joint effusion	Abnormal accumulation of fluid in or around the ankle joint.		hp.json		http://purl.obolibrary.org/obo/HP_0032063		
UBERON:0036362	biolink:AnatomicalEntity	wall of anal canal		FMA:15704	hp.json	anal canal wall	http://purl.obolibrary.org/obo/UBERON_0036362		
HP:0032068	biolink:PhenotypicFeature	Increased urinary mucus	An increased amount of urinary mucus. A small amount of mucus is produced by mucous membrane epithelial cells of the urinary tract. An increased amount of mucus can be detected upon urinalysis or other assays and may indicate conditions such as urinary tract infection, urinary tract reconstruction involving the use of bowel segments, or contamination of the urine sample prior to urinalysis.		hp.json		http://purl.obolibrary.org/obo/HP_0032068		
HP:0032069	biolink:PhenotypicFeature	Anti-thyroglobulin antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react to thyroglobulin.		hp.json	Anti-thyroid globulin antibody positivity|TgAbs	http://purl.obolibrary.org/obo/HP_0032069		
HP:0032064	biolink:PhenotypicFeature	Gastrointestinal eosinophilia	Eosinophilic infiltration of one or more gastrointestinal organs. Gastrointestinal eosinophilia is a broad term for abnormal eosinophil accumulation in the GI tract, involving many different disease identities. These diseases include primary eosinophil associated gastrointestinal diseases, gastrointestinal eosinophilia in HES and all gastrointestinal eosinophilic states associated with known causes. Each of these diseases has its unique features but there is no absolute boundary between them.		hp.json	Eosinophilic gastrointestinal disease|GI eosinophilia|Eosinophilic gastroenteritis|Eosinophilic gastrointestinal disorders|Eosinophilic enteritis	http://purl.obolibrary.org/obo/HP_0032064		
HP:0032065	biolink:PhenotypicFeature	Abnormal serum bicarbonate concentration	Any deviation from the normal concentration of bicarbonate, HCO3[-], in the circulation.		hp.json	Abnormal serum HCO3 concentration	http://purl.obolibrary.org/obo/HP_0032065		
HP:0032066	biolink:PhenotypicFeature	Decreased serum bicarbonate concentration	An abnormal reduction of the concentration of bicarbonate, HCO3[-], in the circulation.		hp.json	Decreased serum HCO3 concentration	http://purl.obolibrary.org/obo/HP_0032066		
HP:0032067	biolink:PhenotypicFeature	Elevated serum bicarbonate concentration	An abnormal increase in the concentration of bicarbonate, HCO3[-], in the circulation.		hp.json	Elevated serum HCO3 concentration	http://purl.obolibrary.org/obo/HP_0032067		
GO:2001141	biolink:BiologicalProcess	regulation of RNA biosynthetic process	Any process that modulates the frequency, rate or extent of RNA biosynthetic process.		hp.json	regulation of RNA anabolism|regulation of RNA biosynthesis|regulation of RNA synthesis|regulation of RNA formation	http://purl.obolibrary.org/obo/GO_2001141		
HP:0020093	biolink:PhenotypicFeature	Recurrent deep organ abscess formation	Repeated episodes of the formation of abscesses in organs. An abscess is a circumscribed area of pus or necrotic debris in the parenchyma or an organ.		hp.json		http://purl.obolibrary.org/obo/HP_0020093		
CL:0002454	biolink:Cell	Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell	Cd4-negative, CD8_alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8_alpha-negative and is CD205-positive.		hp.json	DC.8-4-11b+|spleen double-negative dendritic cell	http://purl.obolibrary.org/obo/CL_0002454		
GO:0060322	biolink:BiologicalProcess	head development	The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0060322		
HP:0020095	biolink:PhenotypicFeature	Prolonged need of intravenous antibiotic therapy	Clinical assessment of a requirement to treat with intravenous antibiotics over an unusually prolonged period of time.		hp.json		http://purl.obolibrary.org/obo/HP_0020095		
CL:0002453	biolink:Cell	oligodendrocyte precursor cell	A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons.		hp.json	O-2A/OPC|oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell|O2A/OPC|oligodendrocyte/type-2 astrocyte progenitor cell	http://purl.obolibrary.org/obo/CL_0002453		
GO:0060323	biolink:BiologicalProcess	head morphogenesis	The process in which the anatomical structures of the head are generated and organized. The head is the anterior-most division of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0060323		
GO:0060324	biolink:BiologicalProcess	face development	The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.		hp.json		http://purl.obolibrary.org/obo/GO_0060324		
GO:0060325	biolink:BiologicalProcess	face morphogenesis	The process in which the anatomical structures of the face are generated and organized. The face is the ventral division of the head.		hp.json		http://purl.obolibrary.org/obo/GO_0060325		
HP:0020091	biolink:PhenotypicFeature	Post-vaccination rotavirus infection	Infection with live attenuated rotavirus vaccine following vaccination.		hp.json		http://purl.obolibrary.org/obo/HP_0020091		
GO:0098916	biolink:BiologicalProcess	anterograde trans-synaptic signaling	Cell-cell signaling from pre to post-synapse, across the synaptic cleft.		hp.json		http://purl.obolibrary.org/obo/GO_0098916		
GO:0060326	biolink:BiologicalProcess	cell chemotaxis	The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).		hp.json		http://purl.obolibrary.org/obo/GO_0060326		
GO:0098917	biolink:BiologicalProcess	retrograde trans-synaptic signaling	Cell-cell signaling from post to pre-synapse, across the synaptic cleft.		hp.json		http://purl.obolibrary.org/obo/GO_0098917		
HP:0020090	biolink:PhenotypicFeature	Post-vaccination polio	Infection with live attenuated polio vaccine following vaccination. This is an extreemely rare event that may indicate immunocompromise.		hp.json		http://purl.obolibrary.org/obo/HP_0020090		
HP:0020097	biolink:PhenotypicFeature	Infection due to encapsulated bacteria	An infection by an encapsulated bacterial agent. Isolates which cause invasive disease are usually surrounded by a polysaccharide capsule, which is a major virulence factor and the key antigen in protective protein-polysaccharide conjugate vaccines.		hp.json		http://purl.obolibrary.org/obo/HP_0020097		
HP:0020096	biolink:PhenotypicFeature	Recurrent streptococcal infections	Increased susceptibility to streptococcal infections, as manifested by recurrent episodes of streptococcal infections.		hp.json		http://purl.obolibrary.org/obo/HP_0020096		
HP:0020099	biolink:PhenotypicFeature	Severe norovirus infection	An unusually severe course of infection with Human norovirus, previously known as Norwalk virus. Norovirus, an RNA virus of the family Caliciviridae, is a human enteric pathogen. Norovirus infection-associated illness may also be more prolonged and severe in immunocompromised individuals and may be associated with remarkably persistent viral excretion in some of these individuals.		hp.json		http://purl.obolibrary.org/obo/HP_0020099		
HP:0020098	biolink:PhenotypicFeature	obsolete Herpes encephalitis			hp.json		http://purl.obolibrary.org/obo/HP_0020098		
HP:0002814	biolink:PhenotypicFeature	Abnormality of the lower limb	An abnormality of the leg.	UMLS:C1096086|SNOMEDCT_US:449715001	hp.json	Abnormality of the lower limb|Abnormality of the leg|Lower limb deformities	http://purl.obolibrary.org/obo/HP_0002814		hposlim_core
HP:0002815	biolink:PhenotypicFeature	Abnormality of the knee	An abnormality of the knee joint or surrounding structures.	UMLS:C4025676	hp.json	Abnormality of the knee	http://purl.obolibrary.org/obo/HP_0002815		hposlim_core
HP:0002812	biolink:PhenotypicFeature	Coxa vara	Coxa vara includes all forms of decrease of the femoral neck shaft angle (the angle between the neck and the shaft of the femur) to less than 120 degrees.	UMLS:C0239138|MSH:D060905|SNOMEDCT_US:74820003	hp.json		http://purl.obolibrary.org/obo/HP_0002812		
HP:0002813	biolink:PhenotypicFeature	Abnormality of limb bone morphology	Any abnormality of bones of the arms or legs.	UMLS:C4082761	hp.json	Abnormal shape of limb bone|Arm and/or leg bone differences|Limb abnormality	http://purl.obolibrary.org/obo/HP_0002813		
HP:0002818	biolink:PhenotypicFeature	Abnormal morphology of the radius	An abnormality of the radius.	UMLS:C4025675	hp.json	Abnormality of the radius	http://purl.obolibrary.org/obo/HP_0002818		hposlim_core
HP:0002816	biolink:PhenotypicFeature	Genu recurvatum	An abnormally increased extension of the knee joint, so that the knee can bend backwards.	UMLS:C0546964|MEDDRA:10018194	hp.json	Knee hyperextension|Genu recurvata|Back knee	http://purl.obolibrary.org/obo/HP_0002816		hposlim_core
HP:0002817	biolink:PhenotypicFeature	Abnormality of the upper limb	An abnormality of the arm.	UMLS:C4020900	hp.json	Abnormality of the arm|Abnormality of the upper limb	http://purl.obolibrary.org/obo/HP_0002817		
HP:0002810	biolink:PhenotypicFeature	Dumbbell-shaped metaphyses		UMLS:C3277123	hp.json	Dumbbell shaped metaphyses|Dumbbell shaped wide portion of long bone|Dumbbell shaped metaphysis	http://purl.obolibrary.org/obo/HP_0002810		
HP:0002825	biolink:PhenotypicFeature	Caudal appendage	The presence of a tail-like skin appendage located adjacent to the sacrum.	UMLS:C3277117	hp.json	Human tail|Coccygeal tail	http://purl.obolibrary.org/obo/HP_0002825		hposlim_core
HP:0002826	biolink:PhenotypicFeature	Halberd-shaped pelvis	An anomalous radiographic appearance of the developing pelvis, in which the greater ischiadic noth (incisura ischiadica major) is shallow and the pelvis takes on the appearance said to resemble a halberd (a weapon especially of the 15th and 16th centuries consisting typically of a battle-ax and pike mounted on a handle).	UMLS:C3277119	hp.json	Halberd-shaped pelvis bone	http://purl.obolibrary.org/obo/HP_0002826		
HP:0002823	biolink:PhenotypicFeature	Abnormality of femur morphology	Any anomaly of the structure of the femur.	UMLS:C4021750	hp.json	Abnormality of the thighbone|Abnormality of the femora	http://purl.obolibrary.org/obo/HP_0002823		
HP:0002829	biolink:PhenotypicFeature	Arthralgia	Joint pain.	UMLS:C0003862|MSH:D018771|SNOMEDCT_US:57676002	hp.json	Arthralgias|Joint pain|Joint pains|Arthritic pain	http://purl.obolibrary.org/obo/HP_0002829		
HP:0002827	biolink:PhenotypicFeature	Hip dislocation	Displacement of the femur from its normal location in the hip joint.	UMLS:C0019554|SNOMEDCT_US:157265008|MSH:D006617	hp.json	Dislocation of hip|Hip dislocation|Dislocated hips	http://purl.obolibrary.org/obo/HP_0002827		
HP:0002828	biolink:PhenotypicFeature	Multiple joint contractures		UMLS:C0158118|SNOMEDCT_US:202264009|SNOMEDCT_US:19393004	hp.json		http://purl.obolibrary.org/obo/HP_0002828		
HP:0002821	biolink:PhenotypicFeature	Neuropathic arthropathy		UMLS:C0003892|SNOMEDCT_US:359554008|SNOMEDCT_US:67536000|MSH:D001177	hp.json	Charcot joint|Charcot arthropathy	http://purl.obolibrary.org/obo/HP_0002821		
HP:0002822	biolink:PhenotypicFeature	Hyperplasia of the femoral trochanters		UMLS:C3277120	hp.json	Hyperplastic femoral trochanters	http://purl.obolibrary.org/obo/HP_0002822		
CL:0000906	biolink:Cell	activated CD8-positive, alpha-beta T cell	A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative.		hp.json	activated CD8-positive, alpha-beta T-cell|activated CD8-positive, alpha-beta T lymphocyte|activated CD8-positive, alpha-beta T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000906		
CL:0000907	biolink:Cell	central memory CD8-positive, alpha-beta T cell	CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json	central CD8-positive, alpha-beta memory T-lymphocyte|central memory CD8-positive, alpha-beta T-lymphocyte|central CD8-positive, alpha-beta memory T cell|central CD8-positive, alpha-beta memory T-cell|central CD8-positive, alpha-beta memory T lymphocyte|central memory CD8-positive, alpha-beta T-cell|central memory CD8+ T cell|central memory CD8-positive, alpha-beta T lymphocyte	http://purl.obolibrary.org/obo/CL_0000907		
RO:0000092	biolink:NamedThing	disposition of	inverse of has disposition		hp.json		http://purl.obolibrary.org/obo/RO_0000092		http://purl.obolibrary.org/obo/RO_0002259
CL:0000909	biolink:Cell	CD8-positive, alpha-beta memory T cell	A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell.		hp.json	T.8Mem.Sp|CD8-positive, alpha-beta memory T-cell|CD8-positive, alpha-beta memory T lymphocyte|CD8-positive, alpha-beta memory T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000909		
RO:0000091	biolink:NamedThing	has disposition	a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence		hp.json		http://purl.obolibrary.org/obo/RO_0000091		
GO:0003097	biolink:NamedThing	renal water transport			hp.json		http://purl.obolibrary.org/obo/GO_0003097		
CL:0000900	biolink:Cell	naive thymus-derived CD8-positive, alpha-beta T cell	A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.		hp.json	naive thymus-dervied CD8-positive, alpha-beta T-cell|naive thymus-dervied CD8-positive, alpha-beta T lymphocyte|naive CD8+ T cell|naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte|T.8Nve.Sp	http://purl.obolibrary.org/obo/CL_0000900		
GO:0003094	biolink:NamedThing	glomerular filtration			hp.json		http://purl.obolibrary.org/obo/GO_0003094		
GO:0003093	biolink:NamedThing	regulation of glomerular filtration			hp.json		http://purl.obolibrary.org/obo/GO_0003093		
CHEBI:17608	biolink:ChemicalSubstance	D-aldohexose	Any D-aldose having a chain of six carbon atoms in the molecule.		hp.json	D-aldohexoses	http://purl.obolibrary.org/obo/CHEBI_17608		3_STAR
CL:0000904	biolink:Cell	central memory CD4-positive, alpha-beta T cell	CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json	central memory CD4+ T cell|central memory CD4-positive, alpha-beta T-cell|central memory CD4-positive, alpha-beta T lymphocyte|central CD4-positive, alpha-beta memory T cell|central memory CD4-positive, alpha-beta T-lymphocyte|central CD4-positive, alpha-beta memory T-cell|central CD4-positive, alpha-beta memory T lymphocyte|central CD4-positive, alpha-beta memory T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000904		
RO:0000081	biolink:NamedThing	role of	a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence		hp.json		http://purl.obolibrary.org/obo/RO_0000081		
RO:0000080	biolink:NamedThing	quality of	a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence		hp.json		http://purl.obolibrary.org/obo/RO_0000080		
HP:0002803	biolink:PhenotypicFeature	Congenital contracture	One or more flexion contractures (a bent joint that cannot be straightened actively or passively) that are present at birth.	UMLS:C0332878	hp.json	Congenital joint contractures|congenital contractures	http://purl.obolibrary.org/obo/HP_0002803		
RO:0000085	biolink:NamedThing	has function	a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence		hp.json		http://purl.obolibrary.org/obo/RO_0000085		
HP:0002804	biolink:PhenotypicFeature	Arthrogryposis multiplex congenita	Multiple congenital contractures in different body areas.	SNOMEDCT_US:111246005|UMLS:C0003886|MSH:D001176|SNOMEDCT_US:77016009	hp.json	Arthrogryposis multiplex|Arthrogryposis, congenital|Multiple congenital contractures|Arthrogryposis	http://purl.obolibrary.org/obo/HP_0002804		
CL:0000911	biolink:Cell	effector T cell	A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response.		hp.json	effector T-cell|effector T lymphocyte|effector T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000911		
CL:0000912	biolink:Cell	helper T cell	A effector T cell that provides help in the form of secreted cytokines to other immune cells.	BTO:0002417	hp.json	helper T-cell|helper T lymphocyte|T-helper cell|helper T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000912		
HP:0002808	biolink:PhenotypicFeature	Kyphosis	Exaggerated anterior convexity of the thoracic vertebral column.	SNOMEDCT_US:414564002|UMLS:C0022821|UMLS:C1845112|MSH:D007738	hp.json	Hyperkyphosis|Round back|Gibbus deformity|Hunched back	http://purl.obolibrary.org/obo/HP_0002808		hposlim_core
CL:0000913	biolink:Cell	effector memory CD8-positive, alpha-beta T cell	CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.		hp.json	effector CD8-positive, alpha-beta memory T cell|effector CD8-positive, alpha-beta memory T-cell|effector CD8-positive, alpha-beta memory T lymphocyte|effector memory CD8+ T cell|effector memory CD8-positive, alpha-beta T-cell|effector memory CD8-positive, alpha-beta T lymphocyte|effector CD8-positive, alpha-beta memory T-lymphocyte|effector memory CD8-positive, alpha-beta T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000913		
RO:0000087	biolink:Protein	has role	a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence	RO:0000087	hp.json		http://purl.obolibrary.org/obo/RO_0000087		
HP:0002805	biolink:PhenotypicFeature	Accelerated bone age after puberty		UMLS:C1860825	hp.json	Accelerated bone age after puberty	http://purl.obolibrary.org/obo/HP_0002805		
RO:0000086	biolink:Protein	has quality	a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence	RO:0000086	hp.json		http://purl.obolibrary.org/obo/RO_0000086		
RO:0000079	biolink:NamedThing	function of	a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence		hp.json		http://purl.obolibrary.org/obo/RO_0000079		
HP:0002858	biolink:PhenotypicFeature	Meningioma	The presence of a meningioma, i.e., a benign tumor originating from the dura mater or arachnoid mater.	UMLS:C0025286|NCIT:C3230|MSH:D008579	hp.json	Noncancerous growth of membranes covering brain	http://purl.obolibrary.org/obo/HP_0002858		
HP:0002859	biolink:PhenotypicFeature	Rhabdomyosarcoma		SNOMEDCT_US:302847003|MSH:D012208|SNOMEDCT_US:30924005|NCIT:C3359|UMLS:C0035412	hp.json		http://purl.obolibrary.org/obo/HP_0002859		
HP:0002857	biolink:PhenotypicFeature	Genu valgum	The legs angle inward, such that the knees are close together and the ankles far apart.	SNOMEDCT_US:299330008|MSH:D056304|MEDDRA:10023480|UMLS:C0576093	hp.json	Genua valga|Genu valga|Knee joint valgus deformity|Genu valgus|Knock knees	http://purl.obolibrary.org/obo/HP_0002857		hposlim_core
GO:0003071	biolink:NamedThing	renal system process involved in regulation of systemic arterial blood pressure			hp.json		http://purl.obolibrary.org/obo/GO_0003071		
GO:0003073	biolink:NamedThing	regulation of systemic arterial blood pressure			hp.json		http://purl.obolibrary.org/obo/GO_0003073		
HP:0002850	biolink:PhenotypicFeature	Decreased circulating total IgM	An abnormally decreased level of immunoglobulin M (IgM) in blood.	UMLS:C0239989	hp.json	Reduced IgM levels|IgM deficiency|Decreased IgM level|Decreased IgM	http://purl.obolibrary.org/obo/HP_0002850		
HP:0002851	biolink:PhenotypicFeature	Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells	An abnormally increased proportion of CD4-negative, CD8-negative (double negative or DN) alpha-beta regulatory T cells (Tregs) as compared to total number of T cells.	UMLS:C1858973	hp.json	Increased number of CD4-/CD8- T cells expressing alpha/beta T-cell receptors	http://purl.obolibrary.org/obo/HP_0002851		
GO:0003081	biolink:NamedThing	regulation of systemic arterial blood pressure by renin-angiotensin			hp.json		http://purl.obolibrary.org/obo/GO_0003081		
HP:0002853	biolink:PhenotypicFeature	Increased proportion of HLA DR+ T cells	An elevated proportion of T cells that express human leukocyte antigen (HLA)-DR. HLA-DR is an MHC class II cell surface receptor that presents antigens (peptides of at least 9 amino acids), thereby constituting a ligand for the T-cell receptor. HLA-DR can be upregulated in response to immune stimulation.	UMLS:C1858974	hp.json		http://purl.obolibrary.org/obo/HP_0002853		
HP:0002869	biolink:PhenotypicFeature	Flared iliac wing	Widening of the ilium ala, that is of the wing of the ilium, combined with external rotation, leading to a flared appearance of the iliac wing.	UMLS:C1865841	hp.json	Flared iliac wings	http://purl.obolibrary.org/obo/HP_0002869		hposlim_core
HP:0000206	biolink:PhenotypicFeature	Glossitis	Inflammation of the tongue.	MSH:D005928|SNOMEDCT_US:45534005|UMLS:C0017675	hp.json	Inflammation of the tongue|Lingual inflammation|Smooth swollen tongue	http://purl.obolibrary.org/obo/HP_0000206		hposlim_core
HP:0000205	biolink:PhenotypicFeature	Pursed lips	An abnormality of the appearance of the face caused by constant contraction of the lips leading to a puckered or pursed appearance.	UMLS:C1832130	hp.json	Tightly closed lips|Pursed lips	http://purl.obolibrary.org/obo/HP_0000205		
HP:0002867	biolink:PhenotypicFeature	Abnormal ilium morphology	An abnormality of the ilium, the largest and uppermost bone of the pelvis.	UMLS:C4021746	hp.json	Abnormality of the ilium|Iliac abnormalities	http://purl.obolibrary.org/obo/HP_0002867		hposlim_core
HP:0002868	biolink:PhenotypicFeature	Narrow iliac wing	Decreased width of the wing (or ala) of the ilium (which is the large expanded portion which bounds the greater pelvis laterally).	UMLS:C1836688	hp.json	Narrow iliac wings	http://purl.obolibrary.org/obo/HP_0002868		hposlim_core
HP:0000207	biolink:PhenotypicFeature	Triangular mouth	The presence of a triangular form of the mouth.	UMLS:C1849341	hp.json	Triangular mouth|Triangular shaped mouth|Triangular shaped oral aperture	http://purl.obolibrary.org/obo/HP_0000207		
HP:0002861	biolink:PhenotypicFeature	Melanoma	The presence of a melanoma, a malignant cancer originating from pigment producing melanocytes. Melanoma can originate from the skin or the pigmented layers of the eye (the uvea).	SNOMEDCT_US:372244006|MSH:D008545|NCIT:C3224|UMLS:C0025202|SNOMEDCT_US:2092003	hp.json	Malignant melanoma|Skin cancer (melanoma)|Cancer of skin pigment cells	http://purl.obolibrary.org/obo/HP_0002861		
HP:0002862	biolink:PhenotypicFeature	Bladder carcinoma	The presence of a carcinoma of the urinary bladder.	UMLS:C0699885|NCIT:C2916|SNOMEDCT_US:255108000	hp.json		http://purl.obolibrary.org/obo/HP_0002862		
HP:0000200	biolink:PhenotypicFeature	Short lingual frenulum	The presence of an abnormally short lingual frenulum.	SNOMEDCT_US:249388005|UMLS:C0426501|UMLS:C4280673	hp.json	Short lingual frenum|Hypoplasia of lingual frenum|Hypoplasia of tongue frenulum|Short tongue frenum|Short tongue frenulum|Hypoplasia of tongue frenum|Hypoplasia of lingual frenulum|Deficiency of lingual frenulum|Tight lingual frenulum	http://purl.obolibrary.org/obo/HP_0000200		
GO:0003091	biolink:NamedThing	renal water homeostasis			hp.json		http://purl.obolibrary.org/obo/GO_0003091		
RO:0000057	biolink:NamedThing	has participant	a relation between a process and a continuant, in which the continuant is somehow involved in the process	RO:0000057	hp.json		http://purl.obolibrary.org/obo/RO_0000057		
HP:0002860	biolink:PhenotypicFeature	Squamous cell carcinoma	The presence of squamous cell carcinoma of the skin.	MSH:D018307|UMLS:C0751688|SNOMEDCT_US:402815007|NCIT:C2929|MSH:D002294|UMLS:C0007137|SNOMEDCT_US:28899001	hp.json	Squamous cell cancer	http://purl.obolibrary.org/obo/HP_0002860		
HP:0000202	biolink:PhenotypicFeature	Oral cleft	The presence of a cleft in the oral cavity, the two main types of which are cleft lip and cleft palate. In cleft lip, there is the congenital failure of the maxillary and median nasal processes to fuse, forming a groove or fissure in the lip. In cleft palate, there is a congenital failure of the palate to fuse properly, forming a grooved depression or fissure in the roof of the mouth. Clefts of the lip and palate can occur individually or together. It is preferable to code each defect separately.	UMLS:C0158646|SNOMEDCT_US:253983005|SNOMEDCT_US:66948001|UMLS:C4021813	hp.json	Cleft lip/palate|Cleft lip, cleft palate|Cleft of the mouth|Oral clefting	http://purl.obolibrary.org/obo/HP_0000202		
HP:0002865	biolink:PhenotypicFeature	Medullary thyroid carcinoma	The presence of a medullary carcinoma of the thyroid gland.	SNOMEDCT_US:255032005|UMLS:C0238462|NCIT:C3879|MSH:C536914|SNOMEDCT_US:128916007	hp.json	Medullary thyroid cancer	http://purl.obolibrary.org/obo/HP_0002865		
HP:0000201	biolink:PhenotypicFeature	Pierre-Robin sequence	Pierre Robin malformation is a sequence of developmental malformations characterized by micrognathia (mandibular hypoplasia), glossoptosis and cleft palate.	UMLS:C0031900|SNOMEDCT_US:4602007|MSH:D010855	hp.json	Pierre-robin anomaly|Pierre Robin sequence|Pierre-robin malformation|Pierre-robin deformity|Robin sequence	http://purl.obolibrary.org/obo/HP_0000201		
HP:0002866	biolink:PhenotypicFeature	Hypoplastic iliac wing	Underdevelopment of the ilium ala.	UMLS:C1865027	hp.json	Hypoplastic iliac wings|Small iliac wings|Hypoplastic iliac alae	http://purl.obolibrary.org/obo/HP_0002866		hposlim_core
HP:0002863	biolink:PhenotypicFeature	Myelodysplasia	Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.	SNOMEDCT_US:128623006|MSH:D009190|UMLS:C1851971|SNOMEDCT_US:188736006|SNOMEDCT_US:109995007|UMLS:C3463824	hp.json	Hypoplastic myelodysplasia|Myelodysplastic syndrome	http://purl.obolibrary.org/obo/HP_0002863		
HP:0000204	biolink:PhenotypicFeature	Cleft upper lip	A gap in the upper lip. This is a congenital defect resulting from nonfusion of tissues of the lip during embryonal development.	MSH:D002971|UMLS:C0008924|SNOMEDCT_US:80281008|Fyler:4875	hp.json	Cheiloschisis of upper lip|Cleft upper lip|Cleft of upper lip|Harelip	http://purl.obolibrary.org/obo/HP_0000204		
HP:0002864	biolink:PhenotypicFeature	Paraganglioma of head and neck		UMLS:C1333944	hp.json	Paragangliomas, head and neck	http://purl.obolibrary.org/obo/HP_0002864		
RO:0000052	biolink:NamedThing	characteristic of	a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence.	RO:0000052	hp.json		http://purl.obolibrary.org/obo/RO_0000052		
HP:0002836	biolink:PhenotypicFeature	Bladder exstrophy	Eversion of the posterior bladder wall through the congenitally absent lower anterior abdominal wall and anterior bladder wall.	MSH:D001746|SNOMEDCT_US:61758007|UMLS:C0005689	hp.json	Ectopia vesicae	http://purl.obolibrary.org/obo/HP_0002836		
HP:0002837	biolink:PhenotypicFeature	Recurrent bronchitis	An increased susceptibility to bronchitis as manifested by a history of recurrent bronchitis.	UMLS:C0741796	hp.json	Bronchitis, recurrent	http://purl.obolibrary.org/obo/HP_0002837		
HP:0002834	biolink:PhenotypicFeature	Flared femoral metaphysis		UMLS:C4025674	hp.json	Flared metaphysis of thigh bone	http://purl.obolibrary.org/obo/HP_0002834		
HP:0002835	biolink:PhenotypicFeature	Aspiration	Inspiration of a foreign object into the airway.	UMLS:C2712334|SNOMEDCT_US:413585005|UMLS:C0700198|SNOMEDCT_US:68052005	hp.json	Pulmonary aspiration	http://purl.obolibrary.org/obo/HP_0002835		
RO:0000056	biolink:NamedThing	participates in	a relation between a continuant and a process, in which the continuant is somehow involved in the process	RO:0000056	hp.json		http://purl.obolibrary.org/obo/RO_0000056		
HP:0002839	biolink:PhenotypicFeature	Urinary bladder sphincter dysfunction	Abnormal function of a sphincter of the urinary bladder.	UMLS:C1843663	hp.json	Sphincter disturbance|Sphincter disturbances	http://purl.obolibrary.org/obo/HP_0002839		
RO:0000053	biolink:NamedThing	bearer of	a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence	RO:0000053	hp.json		http://purl.obolibrary.org/obo/RO_0000053		
HP:0002832	biolink:PhenotypicFeature	Calcific stippling	An abnormal punctate (speckled, dot-like) pattern of calcifications in soft tissues within or surrounding bones (as observed on radiographs).	UMLS:C1849993	hp.json	Discrete calcific stippling	http://purl.obolibrary.org/obo/HP_0002832		
HP:0002833	biolink:PhenotypicFeature	Cystic angiomatosis of bone	Disseminated multifocal hemangiomatous or lymphangiomatous lesions of the skeleton. The lesions are lytic, well-defined, round or oval lesions within the medullary cavity, and they have an intact cortex, and manifest variable peripheral sclerosis and may exhibit endosteal scalloping.	UMLS:C4021749	hp.json	Lytic cystic lesions in appendicular bones	http://purl.obolibrary.org/obo/HP_0002833		
HP:0002831	biolink:PhenotypicFeature	Long coccyx		UMLS:C3277116	hp.json	Long tailbone	http://purl.obolibrary.org/obo/HP_0002831		
GO:0015031	biolink:BiologicalProcess	protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	enzyme transport	http://purl.obolibrary.org/obo/GO_0015031		goslim_yeast|goslim_pir|goslim_chembl
GO:0030667	biolink:CellularComponent	secretory granule membrane	The lipid bilayer surrounding a secretory granule.		hp.json	secretory vesicle membrane	http://purl.obolibrary.org/obo/GO_0030667		
HP:0002847	biolink:PhenotypicFeature	Impaired memory B cell generation	Impaired production of memory cells, the B cells that persist for years or an entire lifetime and which confer rapid and enhanced response to secondary challenge.	UMLS:C4025672	hp.json		http://purl.obolibrary.org/obo/HP_0002847		
HP:0002848	biolink:PhenotypicFeature	Decreased specific anti-polysaccharide antibody level	The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against bacterial polysaccharides.	UMLS:C4021747	hp.json	Depressed antibody response to polysaccharide antigens|Specific anti-polysaccharide antibody deficiency|Low specific anti-polysaccharide antibody titer	http://purl.obolibrary.org/obo/HP_0002848		
HP:0002845	biolink:PhenotypicFeature	obsolete Increased proportion of peripheral CD3+ T cells			hp.json		http://purl.obolibrary.org/obo/HP_0002845		
HP:0002846	biolink:PhenotypicFeature	Abnormal B cell morphology	A structural abnormality of B cells.	UMLS:C4021748	hp.json	Abnormality of B cells|Abnormal B cells	http://purl.obolibrary.org/obo/HP_0002846		
HP:0002849	biolink:PhenotypicFeature	Absence of lymph node germinal center	Absence of germinal centers in lymph nodes. Germinal centers are the parts of lymph nodes in which B lymphocytes proliferate, differentiate, mutate through somatic hypermutation and class switch during antibody responses.	UMLS:C1847383	hp.json	Lymph nodes lack germinal centre|Lymphoid germinal center defect|Absence of lymph node germinal centre|Lymph nodes lack germinal center|Lymphoid germinal centre defect	http://purl.obolibrary.org/obo/HP_0002849		
HP:0002840	biolink:PhenotypicFeature	Lymphadenitis	Inflammation of a lymph node.	MSH:D008199|SNOMEDCT_US:19471005|UMLS:C0024205	hp.json	Inflammation of the lymph nodes	http://purl.obolibrary.org/obo/HP_0002840		
HP:0002843	biolink:PhenotypicFeature	Abnormal T cell morphology	An abnormality of T cells.	UMLS:C1855752	hp.json	Abnormality of T cells|Abnormal T cells|Defective cellular immunity|Cellular immune defect	http://purl.obolibrary.org/obo/HP_0002843		
HP:0002841	biolink:PhenotypicFeature	Recurrent fungal infections	Increased susceptibility to fungal infections, as manifested by multiple episodes of fungal infection.	UMLS:C1844384	hp.json	Recurrent fungal infections	http://purl.obolibrary.org/obo/HP_0002841		
HP:0002842	biolink:PhenotypicFeature	Recurrent Burkholderia cepacia infections	Increased susceptibility to infections with Burkholderia cepacia, as manifested by recurrent episodes of infection with this agent.	UMLS:C4025673	hp.json		http://purl.obolibrary.org/obo/HP_0002842		
GO:0030660	biolink:CellularComponent	Golgi-associated vesicle membrane	The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.		hp.json	Golgi vesicle membrane	http://purl.obolibrary.org/obo/GO_0030660		
GO:0030661	biolink:CellularComponent	chitosome membrane	The lipid bilayer surrounding a chitosome.		hp.json		http://purl.obolibrary.org/obo/GO_0030661		
UBERON:0007490	biolink:AnatomicalEntity	keratin-based acellular structure	Acellular anatomical structure whose predominant constituent is keratin.	EHDAA2:0003099|AEO:0000099	hp.json	keratin-based structure	http://purl.obolibrary.org/obo/UBERON_0007490		
GO:0042641	biolink:CellularComponent	actomyosin	Any complex of actin, myosin, and accessory proteins.		hp.json	actomyosin structure|actomyosin complex	http://purl.obolibrary.org/obo/GO_0042641		
UBERON:0007499	biolink:AnatomicalEntity	epithelial sac	An epithelial tube that is open at one end only.	EHDAA2:0003115|AEO:0000115	hp.json		http://purl.obolibrary.org/obo/UBERON_0007499		
CHEBI:17650	biolink:ChemicalSubstance	cortisol	A 17alpha-hydroxy-C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the "stress hormone" as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses	CAS:50-23-7|CAS:50-23-7|PMID:10438974|KEGG:C00735|Beilstein:1354819|PMID:2268561|Patent:US2602769|Wikipedia:Hydrocortisone|Drug_Central:1388|LIPID_MAPS_instance:LMST02030001|LINCS:LSM-5980|KEGG:D00088|CAS:50-23-7|DrugBank:DB00741|PDBeChem:HCY	hp.json	11beta-hydrocortisone|hidrocortisona|Cortisol|17-hydroxycorticosterone|(11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione|Reichstein's substance M|11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione|11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione|Kendall's compound F|cortisol|4-pregnen-11beta,17alpha,21-triol-3,20-dione|hydrocortisonum|hydrocortisone|Hydrocortisone|11beta,17,21-trihydroxypregn-4-ene-3,20-dione	http://purl.obolibrary.org/obo/CHEBI_17650		3_STAR
CHEBI:30623	biolink:ChemicalSubstance	oxalate(2-)	A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of oxalic acid.	Gmelin:2207|PDBeChem:OXL|Reaxys:1905970|Beilstein:1905970|UM-BBD_compID:c0017|CAS:338-70-5|KEGG:C00209	hp.json	oxalate|ox|OXALATE ION|ethanedioate|ethanedioic acid, ion(2-)	http://purl.obolibrary.org/obo/CHEBI_30623		3_STAR
CL:0000988	biolink:Cell	hematopoietic cell	A cell of a hematopoietic lineage.	CALOHA:TS-2017|FMA:70366|FMA:83598|BTO:0000574	hp.json	hemopoietic cell|haemopoietic cell|haematopoietic cell	http://purl.obolibrary.org/obo/CL_0000988		
GO:0040007	biolink:BiologicalProcess	growth	The increase in size or mass of an entire organism, a part of an organism or a cell.		hp.json	non-developmental growth|growth pattern	http://purl.obolibrary.org/obo/GO_0040007		gocheck_do_not_annotate|goslim_plant|goslim_pir|goslim_chembl
GO:0040008	biolink:BiologicalProcess	regulation of growth	Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.		hp.json		http://purl.obolibrary.org/obo/GO_0040008		
UBERON:0007475	biolink:AnatomicalEntity	matrix-based tissue	A tissue whose predominant feature is extracellular matrix which may or may not be highly hydrated or calcified.	EHDAA2:0003081|AEO:0000081	hp.json		http://purl.obolibrary.org/obo/UBERON_0007475		
CL:0000980	biolink:Cell	plasmablast	An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative.	FMA:84371	hp.json	CD27-positive, CD38-positive, CD20-negative B cell|CD20-negative B cell	http://purl.obolibrary.org/obo/CL_0000980		
UBERON:0007473	biolink:AnatomicalEntity	lumen of epithelial sac	The space within an epithelial sphere.	AEO:0000079	hp.json	cavity of vesicle	http://purl.obolibrary.org/obo/UBERON_0007473		
GO:0040011	biolink:BiologicalProcess	locomotion	Self-propelled movement of a cell or organism from one location to another.		hp.json		http://purl.obolibrary.org/obo/GO_0040011		goslim_pir|goslim_chembl|goslim_generic
GO:0040012	biolink:BiologicalProcess	regulation of locomotion	Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.		hp.json		http://purl.obolibrary.org/obo/GO_0040012		
GO:0040013	biolink:BiologicalProcess	negative regulation of locomotion	Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.		hp.json	downregulation of locomotion|down regulation of locomotion|inhibition of locomotion|down-regulation of locomotion	http://purl.obolibrary.org/obo/GO_0040013		
GO:0042670	biolink:BiologicalProcess	retinal cone cell differentiation	The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.		hp.json		http://purl.obolibrary.org/obo/GO_0042670		
GO:0040018	biolink:BiologicalProcess	positive regulation of multicellular organism growth	Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.		hp.json	positive regulation of body growth|positive regulation of body size	http://purl.obolibrary.org/obo/GO_0040018		
GO:0040019	biolink:BiologicalProcess	positive regulation of embryonic development	Any process that activates or increases the frequency, rate or extent of embryonic development.		hp.json	up regulation of embryonic development|activation of embryonic development|stimulation of embryonic development|upregulation of embryonic development|up-regulation of embryonic development	http://purl.obolibrary.org/obo/GO_0040019		
CL:0000990	biolink:Cell	conventional dendritic cell	Conventional dendritic cell is a dendritic cell that is CD11c-high.	FMA:84191	hp.json	dendritic reticular cell|interdigitating cell|veiled cell|type 1 DC|DC1|cDC	http://purl.obolibrary.org/obo/CL_0000990		
GO:0040014	biolink:BiologicalProcess	regulation of multicellular organism growth	Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.		hp.json	regulation of body size|regulation of body growth	http://purl.obolibrary.org/obo/GO_0040014		
GO:0040015	biolink:BiologicalProcess	negative regulation of multicellular organism growth	Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.		hp.json	negative regulation of body growth|negative regulation of body size	http://purl.obolibrary.org/obo/GO_0040015		
GO:0040016	biolink:BiologicalProcess	embryonic cleavage	The first few specialized divisions of an activated animal egg.		hp.json		http://purl.obolibrary.org/obo/GO_0040016		
GO:0040017	biolink:BiologicalProcess	positive regulation of locomotion	Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.		hp.json	up-regulation of locomotion|activation of locomotion|upregulation of locomotion|stimulation of locomotion|up regulation of locomotion	http://purl.obolibrary.org/obo/GO_0040017		
CL:0000995	biolink:Cell	CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor			hp.json	CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid	http://purl.obolibrary.org/obo/CL_0000995		
GO:0040020	biolink:BiologicalProcess	regulation of meiotic nuclear division	Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.		hp.json	regulation of meiosis	http://purl.obolibrary.org/obo/GO_0040020		
GO:0040029	biolink:BiologicalProcess	regulation of gene expression, epigenetic	A process that modulates the frequency, rate or extent of gene expression by remodelling of chromatin by either modifying the chromatin fiber, the nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal.		hp.json		http://purl.obolibrary.org/obo/GO_0040029		goslim_plant
GO:0042695	biolink:BiologicalProcess	thelarche	The beginning of development of the breasts in the female.	Wikipedia:Thelarche	hp.json		http://purl.obolibrary.org/obo/GO_0042695		
GO:0040034	biolink:BiologicalProcess	regulation of development, heterochronic	Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.		hp.json	heterochronic regulation of development|developmental timing|temporal regulation of development	http://purl.obolibrary.org/obo/GO_0040034		
GO:0042696	biolink:BiologicalProcess	menarche	The beginning of the menstrual cycle; the first menstrual cycle in an individual.	Wikipedia:Menarche	hp.json		http://purl.obolibrary.org/obo/GO_0042696		gocheck_do_not_annotate
GO:0042692	biolink:BiologicalProcess	muscle cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.		hp.json	myogenesis	http://purl.obolibrary.org/obo/GO_0042692		
CL:0000970	biolink:Cell	unswitched memory B cell	An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative.		hp.json	unswitched memory B-cell|unswitched memory B lymphocyte|non-class-switched memory B cell|unswitched memory B-lymphocyte|IgD+ memory B cell	http://purl.obolibrary.org/obo/CL_0000970		
GO:0042698	biolink:BiologicalProcess	ovulation cycle	The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.		hp.json		http://purl.obolibrary.org/obo/GO_0042698		
CL:0000972	biolink:Cell	class switched memory B cell	A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface.		hp.json	class switched memory B-lymphocyte|class switched memory B-cell|class switched memory B lymphocyte	http://purl.obolibrary.org/obo/CL_0000972		
CHEBI:17612	biolink:ChemicalSubstance	(3,4-dihydroxyphenyl)acetate	A dihydroxy monocarboxylic acid anion that is the conjugate base of (3,4-dihydroxyphenyl)acetic acid, arising from deprotonation of the carboxy group.	KEGG:C01161|UM-BBD_compID:c0272	hp.json	3,4-dihydroxyphenylacetate|(3,4-dihydroxyphenyl)acetate|homoprotocatechuate	http://purl.obolibrary.org/obo/CHEBI_17612		3_STAR
RO:0002630	biolink:NamedThing	directly negatively regulates	Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2.		hp.json		http://purl.obolibrary.org/obo/RO_0002630		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
CL:0000945	biolink:Cell	lymphocyte of B lineage	A lymphocyte of B lineage with the commitment to express an immunoglobulin complex.		hp.json		http://purl.obolibrary.org/obo/CL_0000945		
CL:0000946	biolink:Cell	antibody secreting cell	A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin.		hp.json		http://purl.obolibrary.org/obo/CL_0000946		
RO:0002629	biolink:NamedThing	directly positively regulates	Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2.		hp.json		http://purl.obolibrary.org/obo/RO_0002629		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
CL:0000954	biolink:Cell	small pre-B-II cell	A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes.		hp.json	small pre-BII cell	http://purl.obolibrary.org/obo/CL_0000954		
CL:0000955	biolink:Cell	pre-B-II cell	A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain.	BTO:0001133|CALOHA:TS-0819	hp.json	pre-B-lymphocyte|pre-BII cell	http://purl.obolibrary.org/obo/CL_0000955		
CHEBI:17634	biolink:ChemicalSubstance	D-glucose	A glucose with D-configuration.	CAS:50-99-7|CAS:50-99-7	hp.json	D(+)-glucose|D-glucose|grape sugar|D-(+)-glucose|dextrose|D-gluco-hexose|Traubenzucker	http://purl.obolibrary.org/obo/CHEBI_17634		3_STAR
GO:0005615	biolink:CellularComponent	extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.	NIF_Subcellular:sao1425028079	hp.json	intercellular space	http://purl.obolibrary.org/obo/GO_0005615		goslim_generic|prokaryote_subset|goslim_drosophila|goslim_chembl
HP:0012187	biolink:PhenotypicFeature	Increased erythrocyte protoporphyrin concentration	An increased concentration of protoporphyrins in erythrocytes.	UMLS:C4023007	hp.json		http://purl.obolibrary.org/obo/HP_0012187		
HP:0012188	biolink:PhenotypicFeature	Hyperemesis gravidarum	Excessive vomiting in early pregnancy, leading to the loss of 5% or more of body weight.	SNOMEDCT_US:14094001|UMLS:C0020450|MSH:D006939	hp.json		http://purl.obolibrary.org/obo/HP_0012188		
HP:0012189	biolink:PhenotypicFeature	Hodgkin lymphoma	A type of lymphoma characterized microscopically by multinucleated Reed-Sternberg cells.	UMLS:C0019829|SNOMEDCT_US:70600005|SNOMEDCT_US:118602004|MSH:D006689|SNOMEDCT_US:118605002|SNOMEDCT_US:118606001|SNOMEDCT_US:118599009|SNOMEDCT_US:46923007|SNOMEDCT_US:74189002|SNOMEDCT_US:14537002	hp.json	Hodgkin disease|Hodgkin's lymphoma	http://purl.obolibrary.org/obo/HP_0012189		
HP:0012180	biolink:PhenotypicFeature	Cystic medial necrosis	A disorder of large arteries, in particular the aorta, characterized by an accumulation of basophilic ground substance in the media with cyst-like lesions associated with degenerative changes of collagen, elastin and the vascular smooth muscle cells.	SNOMEDCT_US:42182000|SNOMEDCT_US:45894003|SNOMEDCT_US:234021009|MSH:C536230|UMLS:C0392775	hp.json	Arterial cystic medial necrosis	http://purl.obolibrary.org/obo/HP_0012180		
HP:0012181	biolink:PhenotypicFeature	Entrapment neuropathy	Malfunction of a peripheral nerve resulting from mechanical compression of the nerve roots from internal or external causes and leading to a conduction block or axonal loss.	SNOMEDCT_US:45781009|UMLS:C1510429|MSH:D009408	hp.json		http://purl.obolibrary.org/obo/HP_0012181		
HP:0012182	biolink:PhenotypicFeature	Oropharyngeal squamous cell carcinoma	A squamous cell carcinoma that originates in the oropharnyx.	SNOMEDCT_US:423464009|UMLS:C0280313|SNOMEDCT_US:707585008	hp.json		http://purl.obolibrary.org/obo/HP_0012182		
HP:0012183	biolink:PhenotypicFeature	Hyperplastic colonic polyposis	Presence of multiple hyperplastic polyps in the colon. Hyperplastic polyps are generally about 5 mm in size and show hyperplastic mucosal proliferation.	UMLS:C4023010	hp.json		http://purl.obolibrary.org/obo/HP_0012183		
HP:0012184	biolink:PhenotypicFeature	Increased HDL cholesterol concentration	An elevated concentration of high-density lipoprotein cholesterol (HDL) in the blood.	SNOMEDCT_US:238080004|UMLS:C0342883|MSH:C564591	hp.json	Increased circulating high-density lipoprotein levels|High blood HDL level|Hyperalphalipoproteinemia	http://purl.obolibrary.org/obo/HP_0012184		
HP:0012185	biolink:PhenotypicFeature	Constrictive median neuropathy	Injury to the median nerve caused by its entrapment at the wrist as it traverses through the carpal tunnel. Clinically, constrictive median neuropathy is characterized by pain, paresthesia, and weakness in the median nerve distribution of the hand.	UMLS:C4023009	hp.json	Carpal tunnel syndrome	http://purl.obolibrary.org/obo/HP_0012185		
HP:0012186	biolink:PhenotypicFeature	Entrapment neuropathy of the ulnar nerve at elbow	An entrapment neuropathy of the ulnar nerve in the cubital tunnel (in the elbow) characterized by numbness in the ring and little fingers and weakness of the intrinsic muscles in the hand.	UMLS:C4023008	hp.json		http://purl.obolibrary.org/obo/HP_0012186		
HP:0000198	biolink:PhenotypicFeature	Absence of Stensen duct		UMLS:C1858569|UMLS:C4280674	hp.json	Agenesis of parotid duct|Absence of parotid duct|Agenesis of stensen duct|Failure of development of parotid duct|Failure of development of stensen duct|Absent stensen duct|Missing parotid duct|Missing stensen duct	http://purl.obolibrary.org/obo/HP_0000198		
HP:0000197	biolink:PhenotypicFeature	Abnormal parotid gland morphology	Any abnormality of the parotid glands, which are the salivary glands that are located in the subcutaneous tissues of the face overlying the mandibular ramus and anterior and inferior to the external ear.	UMLS:C4025880	hp.json	Abnormality of parotid gland|Anomaly of the parotid gland	http://purl.obolibrary.org/obo/HP_0000197		
UBERON:0007530	biolink:AnatomicalEntity	migrating mesenchyme population	Mesenchymal cells that are migrating.	EHDAA2:0003152|AEO:0000152	hp.json		http://purl.obolibrary.org/obo/UBERON_0007530		
HP:0000199	biolink:PhenotypicFeature	Tongue nodules		UMLS:C0241438	hp.json	Lingual nodules	http://purl.obolibrary.org/obo/HP_0000199		
HP:0000190	biolink:PhenotypicFeature	Abnormal oral frenulum morphology	An abnormality of the lingual frenulum, that is of the small fold of mucous membrane that attaches the tongue to the floor of the mouth, or the presence of accessory frenula in the oral cavity.	UMLS:C4025881	hp.json	Abnormality of oral frenum|Abnormality of frenum of tongue|Abnormality of oral frenula|Abnormality of lingual frenum	http://purl.obolibrary.org/obo/HP_0000190		
HGNC:12805	biolink:Gene	XDH (human)	A protein coding gene XDH in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12805		
HP:0000191	biolink:PhenotypicFeature	Accessory oral frenulum	Extra fold of tissue extending from the alveolar ridge to the inner surface of the upper or lower lip.	UMLS:C4021814	hp.json	Accessory oral frenum|Supernumerary oral frenum|Extra oral frenum|Extra oral frenulum|Supernumerary oral frenulum|Multiple oral frenula	http://purl.obolibrary.org/obo/HP_0000191		hposlim_core
HP:0000194	biolink:PhenotypicFeature	Open mouth	A facial appearance characterized by a permanently or nearly permanently opened mouth.	SNOMEDCT_US:262016004|UMLS:C0240379	hp.json	Open mouth appearance|Slack jawed appearance|Gaped jawed appearance|Open mouth|Gaped mouthed appearance	http://purl.obolibrary.org/obo/HP_0000194		
HP:0000193	biolink:PhenotypicFeature	Bifid uvula	Uvula separated into two parts most easily seen at the tip.	UMLS:C0266122|SNOMEDCT_US:18910001	hp.json	Uvula bifida|Split uvula|Bifid palatine uvula|Cleft of uvula|Cleft uvula|Forked uvula	http://purl.obolibrary.org/obo/HP_0000193		hposlim_core
HP:0000196	biolink:PhenotypicFeature	Lower lip pit	Depression located on the vermilion of the lower lip, usually paramedian.	UMLS:C1861544	hp.json		http://purl.obolibrary.org/obo/HP_0000196		
HP:0012176	biolink:PhenotypicFeature	Abnormal natural killer cell morphology	An anomaly of the natural killer cell, which is a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors. It also regulates immune responses via cytokine release and direct contact with other cells.	UMLS:C4021098	hp.json	Abnormality of natural killer cells|Abnormal NK cells	http://purl.obolibrary.org/obo/HP_0012176		
HP:0012177	biolink:PhenotypicFeature	Abnormal natural killer cell physiology	A functional anomaly of the natural killer cell.	UMLS:C4023012	hp.json		http://purl.obolibrary.org/obo/HP_0012177		
HP:0012178	biolink:PhenotypicFeature	Reduced natural killer cell activity	Reduced ability of the natural killer cell to function in the adaptive immune response.	UMLS:C1839969	hp.json		http://purl.obolibrary.org/obo/HP_0012178		
HP:0012179	biolink:PhenotypicFeature	Craniofacial dystonia	A form of focal dystonia affecting the face and especially the jaw that is induced by the act of speaking. It is an involuntary contraction of the masticatory muscles, resulting in dysarthria or dysphagia.	UMLS:C1851915|UMLS:C4023011|UMLS:C4072883	hp.json	Facial Dystonia|Abnormal craniofacial muscle tone|Abnormal craniofacial posture|Distorted craniofacial posture|Abnormal facial muscle tone	http://purl.obolibrary.org/obo/HP_0012179		
GO:0005622	biolink:CellularComponent	intracellular anatomical structure	A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.	Wikipedia:Intracellular	hp.json	nucleocytoplasm|intracellular|protoplasm|protoplast|internal to cell	http://purl.obolibrary.org/obo/GO_0005622		gocheck_do_not_annotate|goslim_plant|goslim_metagenomics|goslim_chembl
GO:0005623	biolink:CellularComponent	obsolete cell	OBSOLETE. The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.	Wikipedia:Cell_(biology)|NIF_Subcellular:sao1813327414	hp.json		http://purl.obolibrary.org/obo/GO_0005623		
HP:0012170	biolink:PhenotypicFeature	Nail-biting	Habitual biting of one's own fingernails.	UMLS:C0027338|MSH:D009259|ICD-10:F98.8|SNOMEDCT_US:37298006	hp.json	Onychophagy|Onychophagia|Nail-biting	http://purl.obolibrary.org/obo/HP_0012170		
HP:0012171	biolink:PhenotypicFeature	Stereotypical hand wringing	Habitual clasping and squeezing of the hands.	UMLS:C4023014	hp.json		http://purl.obolibrary.org/obo/HP_0012171		
HP:0012172	biolink:PhenotypicFeature	Stereotypical body rocking	Habitual repetitive movement of the body.	UMLS:C4023013	hp.json		http://purl.obolibrary.org/obo/HP_0012172		
HP:0012173	biolink:PhenotypicFeature	Orthostatic tachycardia	An increase in heart rate with standing of 30 beats per minute or more.	UMLS:C4021099	hp.json	Postural tachycardia	http://purl.obolibrary.org/obo/HP_0012173		
HP:0012174	biolink:PhenotypicFeature	Glioblastoma multiforme	A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis, pleomorphic nuclei and cells, and microvascular proliferation.	UMLS:C1621958|SNOMEDCT_US:393563007|MSH:D005909|SNOMEDCT_US:63634009	hp.json	Glioblastoma	http://purl.obolibrary.org/obo/HP_0012174		
HP:0012175	biolink:PhenotypicFeature	Resistance to activated protein C	Poor anticoagulant response to activated protein C. A plasma is termed 'APC resistant' when the addition of exogenous APC fails to prolong its clotting time in an activated partial thromboplastin time assay.	SNOMEDCT_US:421527008|UMLS:C0600433|MSH:D020016	hp.json	Activated protein C resistance	http://purl.obolibrary.org/obo/HP_0012175		
UBERON:0007521	biolink:AnatomicalEntity	smooth muscle sphincter	A ring of smooth muscle cells whose contraction closes the opening of the ring.	EHDAA2:0003143|AEO:0000143	hp.json		http://purl.obolibrary.org/obo/UBERON_0007521		
UBERON:0007529	biolink:AnatomicalEntity	loose mesenchyme tissue	Mesenchyme whose cells are embedded in obvious amounts of extracellular matrix.	AEO:0000151|EHDAA2:0003151	hp.json		http://purl.obolibrary.org/obo/UBERON_0007529		
UBERON:0007524	biolink:AnatomicalEntity	dense mesenchyme tissue	Mesenchyme with little extracellular matrix.	EHDAA2:0003146|AEO:0000146	hp.json		http://purl.obolibrary.org/obo/UBERON_0007524		
UBERON:0007522	biolink:AnatomicalEntity	striated muscle sphincter	A ring of striated muscle cells whose contraction closes the opening of the ring.	EHDAA2:0003144|AEO:0000144	hp.json		http://purl.obolibrary.org/obo/UBERON_0007522		
HP:0012165	biolink:PhenotypicFeature	Oligodactyly	A developmental defect resulting in the presence of fewer than the normal number of digits.	UMLS:C3887496	hp.json		http://purl.obolibrary.org/obo/HP_0012165		
HP:0012166	biolink:PhenotypicFeature	Skin-picking	Repetitive and compulsive picking of skin which results in tissue damage.	UMLS:C1696701|ICD-10:F63.3	hp.json	Compulsive skin picking|Dermatillomania	http://purl.obolibrary.org/obo/HP_0012166		
HP:0012167	biolink:PhenotypicFeature	Hair-pulling	A phenomenon in which persons repetitively pull out their own hair, resulting in noticeable hair loss.	UMLS:C0040953|MSH:D014256|SNOMEDCT_US:17155009	hp.json	Trichotillomania	http://purl.obolibrary.org/obo/HP_0012167		
HP:0012168	biolink:PhenotypicFeature	Head-banging	Habitual striking of one's own head against a surface such as a mattress or wall of a crib.	UMLS:C0018672|SNOMEDCT_US:43954004|MSH:D019956	hp.json	Head-banging	http://purl.obolibrary.org/obo/HP_0012168		
HP:0012169	biolink:PhenotypicFeature	Self-biting	Habitual biting of one's own body.	UMLS:C0424375|SNOMEDCT_US:248072009	hp.json		http://purl.obolibrary.org/obo/HP_0012169		
HP:0012160	biolink:PhenotypicFeature	Intracranial internal carotid artery dissection	A separation (dissection) of the layers of the intracranial portion of the internal carotid artery wall.	UMLS:C4023017	hp.json		http://purl.obolibrary.org/obo/HP_0012160		
HP:0012161	biolink:PhenotypicFeature	External carotid artery dissection	A separation (dissection) of the layers of the external carotid artery wall.	UMLS:C4023016	hp.json		http://purl.obolibrary.org/obo/HP_0012161		
HP:0012162	biolink:PhenotypicFeature	Common carotid artery dissection	A separation (dissection) of the layers of the common carotid artery wall.	UMLS:C4023015	hp.json		http://purl.obolibrary.org/obo/HP_0012162		
HP:0012163	biolink:PhenotypicFeature	Carotid artery dilatation	A dilatation (balooning or bulging out of the vessel wall) of a carotid artery.	SNOMEDCT_US:233988005|UMLS:C0340639	hp.json	Carotid artery aneurysm	http://purl.obolibrary.org/obo/HP_0012163		
HP:0012164	biolink:PhenotypicFeature	Asterixis	A clinical sign indicating a lapse of posture and is usually manifest by a bilateral flapping tremor at the wrist, metacarpophalangeal, and hip joints.	SNOMEDCT_US:32838008|UMLS:C0232766|MSH:D020820	hp.json		http://purl.obolibrary.org/obo/HP_0012164		
HP:0000176	biolink:PhenotypicFeature	Submucous cleft hard palate	Hard-palate submucous clefts are characterized by bony defects in the midline of the bony palate that are covered by the mucous membrane of the roof of the mouth. It may be possible to detect a submucous cleft hard palate upon palpation as a notch in the bony palate.	UMLS:C4020894|SNOMEDCT_US:43437003|UMLS:C0432103	hp.json	Partial thickness cleft hard palate|Submucosal cleft palate|Submucous clefting	http://purl.obolibrary.org/obo/HP_0000176		
HP:0000175	biolink:PhenotypicFeature	Cleft palate	Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate).	SNOMEDCT_US:63567004|MSH:D002972|SNOMEDCT_US:87979003|UMLS:C0008925|Fyler:4876|UMLS:C2981150	hp.json	Cleft palate|Cleft hard and soft palate|Cleft of hard and soft palate|Cleft of palate|Cleft secondary palate|Uranostaphyloschisis|Cleft roof of mouth|Palatoschisis	http://purl.obolibrary.org/obo/HP_0000175		hposlim_core
HP:0000178	biolink:PhenotypicFeature	Abnormality of lower lip	An abnormality of the lower lip.	UMLS:C4025883	hp.json	Anomaly of the lower lip|Malformation of the lower lip|Deformity of the lower lip|Abnormality of lower lip	http://purl.obolibrary.org/obo/HP_0000178		hposlim_core
HP:0000177	biolink:PhenotypicFeature	Abnormality of upper lip	An abnormality of the upper lip.	UMLS:C4025884	hp.json	Deformity of the upper lip|Malformation of the upper lip|Abnormality of upper lip|Anomaly of the upper lip	http://purl.obolibrary.org/obo/HP_0000177		hposlim_core
HP:0000179	biolink:PhenotypicFeature	Thick lower lip vermilion	Increased thickness of the lower lip, leading to a prominent appearance of the lower lip. The height of the vermilion of the lower lip in the midline is more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the lower lip in the frontal view (subjective).	UMLS:C2053437|UMLS:C1839739	hp.json	Full lower lip|Thick red part of the lower lip|Prominent lower lip vermilion|Thick lower lip|Prominent lower lip|Increased height of lower lip vermilion|Increased volume of lower lip|Plump lower lip|Full lower lip vermilion|Increased volume of lower lip vermilion|Thick vermilion border of lower lip	http://purl.obolibrary.org/obo/HP_0000179		
HP:0000172	biolink:PhenotypicFeature	Abnormal uvula morphology	Abnormality of the uvula, the conic projection from the posterior edge of the middle of the soft palate.	UMLS:C4025885	hp.json	Abnormality of the uvula|Abnormality of palatine uvula	http://purl.obolibrary.org/obo/HP_0000172		hposlim_core
HP:0000171	biolink:PhenotypicFeature	Microglossia	Decreased length and width of the tongue.	UMLS:C0025988|UMLS:C0426492|SNOMEDCT_US:249380003|MSH:D014060|SNOMEDCT_US:32614006	hp.json	Rudimentary tongue|Hypoplasia of the tongue|Hypoglossia|Abnormally small tongue|Small tongue|Lingual hypoplasia|Decreased size of tongue|Underdevelopment of the tongue|Hypoplastic tongue	http://purl.obolibrary.org/obo/HP_0000171		hposlim_core
HP:0000174	biolink:PhenotypicFeature	Abnormal palate morphology	Any abnormality of the palate, i.e., of roof of the mouth.	UMLS:C4021815	hp.json	Palatal anomaly|Palate abnormality|Abnormality of the palate|Abnormality of the roof of the mouth	http://purl.obolibrary.org/obo/HP_0000174		hposlim_core
GO:0005604	biolink:CellularComponent	basement membrane	A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.	Wikipedia:Basement_membrane	hp.json	basal lamina|basement lamina|lamina densa	http://purl.obolibrary.org/obo/GO_0005604		
HP:0012154	biolink:PhenotypicFeature	Anhedonia	Inability to experience pleasure activities usually found enjoyable.	UMLS:C0178417|SNOMEDCT_US:247796005|MSH:D059445|SNOMEDCT_US:28669007	hp.json		http://purl.obolibrary.org/obo/HP_0012154		
HP:0012155	biolink:PhenotypicFeature	Decreased corneal sensation	Reduced ability of the cornea to respond to stimulation.	UMLS:C0859996|SNOMEDCT_US:373433005|UMLS:C0271292	hp.json	Reduced corneal sensation|Corneal hypaesthesia|Corneal hypesthesia|Decreased corneal sensitivity	http://purl.obolibrary.org/obo/HP_0012155		
HP:0012156	biolink:PhenotypicFeature	Hemophagocytosis	Phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues.	UMLS:C0876991|SNOMEDCT_US:61070002	hp.json		http://purl.obolibrary.org/obo/HP_0012156		
HP:0012157	biolink:PhenotypicFeature	Subcortical cerebral atrophy	Atrophy of the cerebral subcortical white and gray matter, termed subcortical atrophy, reflects loss of nerve cells in the basal ganglia or fibers in the deep white matter.	UMLS:C4023018	hp.json		http://purl.obolibrary.org/obo/HP_0012157		
HP:0012158	biolink:PhenotypicFeature	Carotid artery dissection	A separation (dissection) of the layers of the carotid artery wall.	UMLS:C0338585	hp.json		http://purl.obolibrary.org/obo/HP_0012158		
HP:0012159	biolink:PhenotypicFeature	Internal carotid artery dissection	A separation (dissection) of the layers of the internal carotid artery wall.	MSH:D020215|UMLS:C0751815|SNOMEDCT_US:705066004	hp.json		http://purl.obolibrary.org/obo/HP_0012159		
HP:0012150	biolink:PhenotypicFeature	Single lineage myelodysplasia	Abnormality/dysplasia of a single myeloid cell (erythroid, granulocytic, or megakaryocytic).	UMLS:C4023019	hp.json		http://purl.obolibrary.org/obo/HP_0012150		
HP:0012151	biolink:PhenotypicFeature	Hemothorax	The presence of blood in the pleural space.	MSH:D006491|UMLS:C0019123|SNOMEDCT_US:31892009	hp.json		http://purl.obolibrary.org/obo/HP_0012151		
HP:0012152	biolink:PhenotypicFeature	Foveoschisis	Splitting of the retinal layers in the macula.	UMLS:C2674407	hp.json	Retinoschisis involving the fovea	http://purl.obolibrary.org/obo/HP_0012152		
HP:0012153	biolink:PhenotypicFeature	Hypotriglyceridemia	An decrease in the level of triglycerides in the blood.	UMLS:C0542037	hp.json	Low blood triglyceride levels|Decreased plasma Tg levels|Decreased circulating Tg levels	http://purl.obolibrary.org/obo/HP_0012153		
HP:0000187	biolink:PhenotypicFeature	Broad alveolar ridges		UMLS:C4280675|UMLS:C1857500	hp.json	Wide alveolar margins|Broad alveolar margins|Wide alveolar processes of jaw|Widened alveolar ridges|Wide gum ridges|Broad alveolar processes of jaw	http://purl.obolibrary.org/obo/HP_0000187		
HP:0000189	biolink:PhenotypicFeature	Narrow palate	Width of the palate more than 2 SD below the mean (objective) or apparently decreased palatal width (subjective).	UMLS:C1398312	hp.json	Narrow palate|Decreased palatal width|Narrow roof of mouth|Decreased transverse dimension of palate	http://purl.obolibrary.org/obo/HP_0000189		hposlim_core
HP:0000188	biolink:PhenotypicFeature	Short upper lip	Decreased width of the upper lip.	UMLS:C1848977	hp.json	Decreased height of upper lip|Vertical deficiency of upper lip|Decreased upper labial height|Decreased upper labial length|Decreased vertical length of upper lip|Short upper lip|Shortening of upper lip	http://purl.obolibrary.org/obo/HP_0000188		
CHEBI:78574	biolink:ChemicalSubstance	pyrimidinecarboxylic acid	Any pyrimidine that bears one or more carboxylic acid substituents.		hp.json	pyrimidinecarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_78574		3_STAR
HP:0000180	biolink:PhenotypicFeature	Lobulated tongue	Multiple indentations and/or elevations on the edge and/or surface of the tongue producing an irregular surface contour.	UMLS:C0431564|SNOMEDCT_US:253752000	hp.json	Bumpy tongue|Lingual lobules|Lobulate tongue	http://purl.obolibrary.org/obo/HP_0000180		hposlim_core
HP:0000183	biolink:PhenotypicFeature	Difficulty in tongue movements		UMLS:C1853406|UMLS:C4280676	hp.json	Hypokinesia of the tongue|Lingual hypokinesia|Difficulty in tongue movements|Difficulty in lingual movements	http://purl.obolibrary.org/obo/HP_0000183		
UBERON:0007503	biolink:AnatomicalEntity	epithelial vesicle	A closed epithelium with a lumen.	EHDAA2:0003119|AEO:0000119	hp.json		http://purl.obolibrary.org/obo/UBERON_0007503		
HP:0000182	biolink:PhenotypicFeature	Movement abnormality of the tongue		UMLS:C4025882	hp.json	Abnormality of lingual movement|Movement abnormality of the tongue	http://purl.obolibrary.org/obo/HP_0000182		
HP:0000185	biolink:PhenotypicFeature	Cleft soft palate	Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency.	MSH:C562950|SNOMEDCT_US:253997002|UMLS:C0432098	hp.json	Cleft of soft palate|Cleft muscular palate|Cleft velum	http://purl.obolibrary.org/obo/HP_0000185		
UBERON:0007501	biolink:AnatomicalEntity	arborizing epithelial duct system	A collection of connected epithelial tubes with a single portal.	EHDAA2:0003117|AEO:0000117	hp.json	arborising epithelial duct system	http://purl.obolibrary.org/obo/UBERON_0007501		
UBERON:0007500	biolink:AnatomicalEntity	epithelial tube open at both ends	An epithelial tube open at both ends that allows fluid flow.	AEO_RETIRED:0000116|RETIRED_EHDAA2:0003116	hp.json		http://purl.obolibrary.org/obo/UBERON_0007500		
CHEBI:30566	biolink:ChemicalSubstance	gamma-aminobutyrate	An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid.	Beilstein:3536873|Reaxys:3536873|Gmelin:559138|KEGG:C00334|PMID:12509893	hp.json	4-Amino-butyrat|4-aminobutanoic acid ion (1-)|4-aminobutyrate|4-aminobutanoate|gamma-aminobutyrate anion|4-Aminobutylate|gamma-aminobutanoate	http://purl.obolibrary.org/obo/CHEBI_30566		3_STAR
GO:0042611	biolink:CellularComponent	MHC protein complex	A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.		hp.json		http://purl.obolibrary.org/obo/GO_0042611		goslim_pir
CHEBI:17578	biolink:ChemicalSubstance	toluene	The simplest member of the class toluenes consisting of a benzene core which bears a single methyl substituent.	PMID:12213539|CAS:108-88-3|PMID:21655021|PMID:11991009|PMID:11846266|PMID:16316648|PMID:18397809|PMID:19635754|KEGG:C01455|PMID:15695158|PMID:21731073|PMID:15119846|PMID:20347282|PMID:16348226|PMID:16601996|CAS:108-88-3|CAS:108-88-3|PMID:15019953|Beilstein:635760|DrugBank:DB01900|PMID:12876426|PMID:17145141|PMID:20837561|PMID:15542760|PMID:15567510|PMID:18832024|PMID:19969016|PMID:12784113|Reaxys:635760|PMID:19825861|PMID:19384711|PMID:15193425|PMID:12237258|PMID:14605898|PMID:19765629|Gmelin:2456|PMID:15796064|PMID:21840036|UM-BBD_compID:c0114|PMID:19928203|PMID:17725881|PMID:14559343|PMID:19429395|PMID:12062755|Wikipedia:Toluene|PMID:17175136|PMID:17497535|PMID:15015825|PMID:14512097|PMID:19261054|PMID:11314682|PDBeChem:MBN|PMID:21802510|PMID:11182169|PMID:21430649	hp.json	toluene|phenylmethane|toluene|toluene|Toluol|Toluen|Toluene|methylbenzene|TOLUENE	http://purl.obolibrary.org/obo/CHEBI_17578		3_STAR
GO:0042613	biolink:CellularComponent	MHC class II protein complex	A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.		hp.json		http://purl.obolibrary.org/obo/GO_0042613		
PR:Q10469	biolink:Protein	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (human)	An alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase that is encoded in the genome of human.	Reactome:R-HSA-975830|UniProtKB:Q10469	hp.json	hMGAT2|beta-1,2-N-acetylglucosaminyltransferase II (human)|GlcNAc-T II (human)|MGAT2|N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II (human)|GNT-II (human)|mannoside acetylglucosaminyltransferase 2 (human)	http://purl.obolibrary.org/obo/PR_Q10469		
GO:0042627	biolink:CellularComponent	chylomicron	A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.	Wikipedia:Chylomicron	hp.json		http://purl.obolibrary.org/obo/GO_0042627		
HP:0012198	biolink:PhenotypicFeature	Juvenile colonic polyposis	The presence of more than 5 juvenile polyps of the colon. The term juvenile polyps refer to a special histopathology and not the age of onset as the polyp might be diagnosed at all ages. The juvenile polyp has a spherical appearance and is microscopically characterized by overgrowth of an oedematous lamina propria with inflammatory cells and cystic glands.	UMLS:C4023006	hp.json		http://purl.obolibrary.org/obo/HP_0012198		
HP:0012199	biolink:PhenotypicFeature	Cluster headache	A type of headache characterized by repeated attacks of unilateral pain lasting 15 to 180 minutes and associated with local autonomic signs.	MSH:D003027|SNOMEDCT_US:230473009|ICD-10:G44.0|SNOMEDCT_US:193947008|SNOMEDCT_US:193031009|UMLS:C0009088	hp.json		http://purl.obolibrary.org/obo/HP_0012199		
RO:0012003	biolink:NamedThing	acts on population of	p acts on population of c iff c' is a collection, has members of type c, and p has participant c	RO:0012003	hp.json		http://purl.obolibrary.org/obo/RO_0012003		http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_ontology
NCBITaxon:197562	biolink:OrganismalEntity	Pancrustacea		PMID:11557979|GC_ID:1|PMID:10874751	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_197562		
NCBITaxon:197563	biolink:OrganismalEntity	Mandibulata		PMID:9727836|PMID:11557979|GC_ID:1	hp.json	mandibulates	http://purl.obolibrary.org/obo/NCBITaxon_197563		
RO:0012008	biolink:NamedThing	results in fusion of		RO:0012008	hp.json		http://purl.obolibrary.org/obo/RO_0012008		http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_ontology
HP:0012190	biolink:PhenotypicFeature	T-cell lymphoma	A type of lymphoma that originates in T-cells.	MSH:D016399|UMLS:C0079772|SNOMEDCT_US:3172003|SNOMEDCT_US:109978004	hp.json	T cell lymphoma	http://purl.obolibrary.org/obo/HP_0012190		
HP:0012191	biolink:PhenotypicFeature	B-cell lymphoma	A type of lymphoma that originates in B-cells.	UMLS:C0079731|MSH:D016393|SNOMEDCT_US:109979007|SNOMEDCT_US:1929004|SNOMEDCT_US:413616009	hp.json	B cell lymphoma	http://purl.obolibrary.org/obo/HP_0012191		
HP:0012192	biolink:PhenotypicFeature	Cutaneous T-cell lymphoma	A type of T-cell lymphoma that exhibits malignant infiltration of the skin.	MSH:D016410|UMLS:C0079773|SNOMEDCT_US:400122007|SNOMEDCT_US:28054005	hp.json		http://purl.obolibrary.org/obo/HP_0012192		
HP:0012193	biolink:PhenotypicFeature	Anaplastic large-cell lymphoma	A type of T-cell lymphoma that is characterized by so-called hallmark cells with a pleomorphic appearance that express the CD30 antigen, are lobulated, and have indented nuclei.	UMLS:C0206180|SNOMEDCT_US:53237008|MSH:D017728|SNOMEDCT_US:277637000	hp.json		http://purl.obolibrary.org/obo/HP_0012193		
HP:0012194	biolink:PhenotypicFeature	Episodic hemiplegia	Transient episodes of weakness of the arm, leg, and in some cases the face on one side of the body.	UMLS:C1863061	hp.json		http://purl.obolibrary.org/obo/HP_0012194		
HP:0012195	biolink:PhenotypicFeature	Irregular respiration	Uneven rhythm of breathing.	SNOMEDCT_US:248585001|UMLS:C0425492	hp.json	Irregular respiratory rhythm	http://purl.obolibrary.org/obo/HP_0012195		
HP:0012196	biolink:PhenotypicFeature	Cheyne-Stokes respiration	An abnormal pattern of respiration characterized by cycles of respiration that are increasingly deeper then shallower with possible periods of apnea. Affected patients may display a 10 to 20 second episode of hypoventilation or apnea, followed by respiration of increased depth and frequency over the course of about one minute. The cycle repeats every 45 seconds to 3 minutes.	SNOMEDCT_US:309155007|UMLS:C1313952|MSH:D002639|UMLS:C0008039|SNOMEDCT_US:271824009	hp.json	Cheyne-Stokes breathing|Periodic respiration	http://purl.obolibrary.org/obo/HP_0012196		
HP:0012197	biolink:PhenotypicFeature	Insulinoma	A type of tumor of the pancreatic beta cells that secretes excess insulin and can result in hypoglycemia.	SNOMEDCT_US:25324008|UMLS:C0021670|SNOMEDCT_US:302822000|MSH:D007340	hp.json	Pancreatic insulinoma	http://purl.obolibrary.org/obo/HP_0012197		
GO:0030659	biolink:CellularComponent	cytoplasmic vesicle membrane	The lipid bilayer surrounding a cytoplasmic vesicle.		hp.json		http://purl.obolibrary.org/obo/GO_0030659		
HP:0012100	biolink:PhenotypicFeature	Abnormal circulating creatinine concentration	An abnormal concentration of creatinine in the blood.	UMLS:C4021101	hp.json	Abnormal circulating creatinine level|Abnormal blood creatinine level|Creatinine levels abnormal	http://purl.obolibrary.org/obo/HP_0012100		
HP:0012101	biolink:PhenotypicFeature	Decreased serum creatinine	An abnormally reduced amount of creatinine in the blood.	UMLS:C0428282|SNOMEDCT_US:166715006	hp.json	Decreased serum creatinine|Reduced creatinine levels|Low blood creatinine level	http://purl.obolibrary.org/obo/HP_0012101		
GO:0030658	biolink:CellularComponent	transport vesicle membrane	The lipid bilayer surrounding a transport vesicle.		hp.json	secretory vesicle membrane|constitutive secretory pathway transport vesicle membrane	http://purl.obolibrary.org/obo/GO_0030658		
HP:0012102	biolink:PhenotypicFeature	Abnormal mitochondrial number	A deviation from the normal number of mitochondria per cell.	UMLS:C4023043	hp.json		http://purl.obolibrary.org/obo/HP_0012102		
HP:0012103	biolink:PhenotypicFeature	Abnormality of the mitochondrion	An anomaly of the mitochondrion, the membranous cytoplasmic organelle the interior of which is subdivided by cristae. The mitochondrion is a self replicating organelle that is the site of tissue respiration.	UMLS:C4023042|UMLS:C4020732	hp.json	Mitochondrial abnormalities	http://purl.obolibrary.org/obo/HP_0012103		
GO:0030656	biolink:BiologicalProcess	regulation of vitamin metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.		hp.json	regulation of vitamin metabolism	http://purl.obolibrary.org/obo/GO_0030656		
HP:0012104	biolink:PhenotypicFeature	Parietal cortical atrophy	Atrophy of the parietal cortex.	UMLS:C4023041	hp.json		http://purl.obolibrary.org/obo/HP_0012104		
HP:0012105	biolink:PhenotypicFeature	Occipital cortical atrophy	Atrophy of the occipital cortex.	UMLS:C4023040	hp.json		http://purl.obolibrary.org/obo/HP_0012105		
HP:0012106	biolink:PhenotypicFeature	Rhizomelic leg shortening	Disproportionate shortening of the proximal segment of the leg (i.e. the femur).	UMLS:C4023039	hp.json		http://purl.obolibrary.org/obo/HP_0012106		
HP:0000118	biolink:PhenotypicFeature	Phenotypic abnormality	A phenotypic abnormality.	UMLS:C4021819	hp.json	Organ abnormality	http://purl.obolibrary.org/obo/HP_0000118		
HP:0000117	biolink:PhenotypicFeature	Renal phosphate wasting	High urine phosphate in the presence of hypophosphatemia.	UMLS:C1845169	hp.json	Decreased tubular maximum for phosphate reabsorption per glomerular filtration rate|Tubular phosphate reabsorption low|Decreased renal tubular phosphate reabsorption	http://purl.obolibrary.org/obo/HP_0000117		
HP:0002779	biolink:PhenotypicFeature	Tracheomalacia		UMLS:C0948187|SNOMEDCT_US:95434006|MSH:D055090	hp.json	Floppy windpipe	http://purl.obolibrary.org/obo/HP_0002779		
HP:0000119	biolink:PhenotypicFeature	Abnormality of the genitourinary system	The presence of any abnormality of the genitourinary system.	MSH:D014564|UMLS:C0042063|SNOMEDCT_US:42030000|SNOMEDCT_US:287085006|UMLS:C4020895|UMLS:C0080276	hp.json	Genitourinary dysplasia|Abnormality of the GU system|Genitourinary disease|Genitourinary abnormality|Urogenital abnormalities|Genitourinary tract anomalies|Urogenital anomalies|Genitourinary tract malformation	http://purl.obolibrary.org/obo/HP_0000119		
GO:0005694	biolink:CellularComponent	chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.	Wikipedia:Chromosome	hp.json	prophase chromosome|interphase chromosome|chromatid	http://purl.obolibrary.org/obo/GO_0005694		goslim_metagenomics|goslim_candida|goslim_agr|goslim_yeast|goslim_generic|goslim_pir|goslim_flybase_ribbon|goslim_drosophila|goslim_aspergillus|goslim_chembl
HP:0000110	biolink:PhenotypicFeature	Renal dysplasia	The presence of developmental dysplasia of the kidney.	MSH:C563261|SNOMEDCT_US:204949001|UMLS:C1619700|UMLS:C3536714	hp.json	Renal adysplasia|Dysplastic kidneys	http://purl.obolibrary.org/obo/HP_0000110		
HP:0002773	biolink:PhenotypicFeature	obsolete Small vertebral bodies			hp.json		http://purl.obolibrary.org/obo/HP_0002773		
HP:0000112	biolink:PhenotypicFeature	Nephropathy	A nonspecific term referring to disease or damage of the kidneys.	MSH:D007674|UMLS:C1408258|UMLS:C0022658|SNOMEDCT_US:90708001	hp.json	Kidney disease|Kidney damage	http://purl.obolibrary.org/obo/HP_0000112		
HP:0000111	biolink:PhenotypicFeature	Renal juxtaglomerular cell hypertrophy/hyperplasia	Increased number and size of the juxtaglomerular cells.	UMLS:C1866496	hp.json		http://purl.obolibrary.org/obo/HP_0000111		
HP:0000114	biolink:PhenotypicFeature	Proximal tubulopathy	Dysfunction of the proximal tubule, which is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle.	UMLS:C1839603	hp.json	Proximal tubular defect|Proximal renal tubulopathy|Proximal tubule dysfunction|Selective proximal tubular damage|Proximal renal tubule defect	http://purl.obolibrary.org/obo/HP_0000114		
HP:0002777	biolink:PhenotypicFeature	Tracheal stenosis		UMLS:C0040583|MSH:D014135|SNOMEDCT_US:11296007	hp.json	Narrowing of windpipe	http://purl.obolibrary.org/obo/HP_0002777		
HP:0000113	biolink:PhenotypicFeature	Polycystic kidney dysplasia	The presence of multiple cysts in both kidneys.	Fyler:4508|SNOMEDCT_US:82525005|UMLS:C1567435|UMLS:C0022680|MSH:D007690	hp.json	Polycystic kidney disease|Polycystic kidneys|Enlarged polycystic kidneys	http://purl.obolibrary.org/obo/HP_0000113		
HP:0002778	biolink:PhenotypicFeature	Abnormal tracheal morphology	A structural anomaly of the trachea.	SNOMEDCT_US:47125007|MSH:D014133|UMLS:C0040580|UMLS:C4025678	hp.json	Tracheal disease|Abnormality of the trachea|Abnormal trachea morphology	http://purl.obolibrary.org/obo/HP_0002778		
HP:0012107	biolink:PhenotypicFeature	Increased fibular diameter	Increased width of the cross sectional diameter of the fibula.	UMLS:C4021100	hp.json	Thick fibula|Wide calf bone|Wide fibula|Thick fibulae	http://purl.obolibrary.org/obo/HP_0012107		
HP:0012108	biolink:PhenotypicFeature	Open angle glaucoma	A type of glaucoma defined by an open, normal appearing anterior chamber angle and raised intraocular pressure,	MSH:C562750|SNOMEDCT_US:77075001|UMLS:C0339573	hp.json	Primary open angle glaucoma	http://purl.obolibrary.org/obo/HP_0012108		
HP:0012109	biolink:PhenotypicFeature	Angle closure glaucoma	A type of glaucomatous optic neuropathy in an eye that has evidence of angle closure (i.e. significant iridotrabecular contact).	UMLS:C0017606|SNOMEDCT_US:392288006	hp.json	Primary angle closure glaucoma	http://purl.obolibrary.org/obo/HP_0012109		
GO:0030642	biolink:BiologicalProcess	cellular sulfate ion homeostasis	Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell.		hp.json	sulphate ion homeostasis	http://purl.obolibrary.org/obo/GO_0030642		
GO:0030643	biolink:BiologicalProcess	cellular phosphate ion homeostasis	Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0030643		
HP:0000128	biolink:PhenotypicFeature	Renal potassium wasting	High urine potassium in the presence of hypokalemia.	UMLS:C1846348	hp.json	Renal K wasting	http://purl.obolibrary.org/obo/HP_0000128		
GO:0003044	biolink:NamedThing	regulation of systemic arterial blood pressure mediated by a chemical signal			hp.json		http://purl.obolibrary.org/obo/GO_0003044		
HP:0000121	biolink:PhenotypicFeature	Nephrocalcinosis	Nephrocalcinosis is the deposition of calcium salts in renal parenchyma.	UMLS:C4280679|MSH:D009397|UMLS:C0027709|SNOMEDCT_US:48638002	hp.json	Too much calcium deposited in kidneys|Increased calcium level in kidney	http://purl.obolibrary.org/obo/HP_0000121		
HP:0000123	biolink:PhenotypicFeature	Nephritis	The presence of inflammation affecting the kidney.	UMLS:C0027697|MSH:D009393|SNOMEDCT_US:52845002	hp.json	Kidney inflammation	http://purl.obolibrary.org/obo/HP_0000123		
HP:0000122	biolink:PhenotypicFeature	Unilateral renal agenesis	A unilateral form of agenesis of the kidney.	UMLS:C0266294|SNOMEDCT_US:55726006|Fyler:4509	hp.json	Absent kidney on one side|Single kidney|Missing one kidney|Unilateral kidney agenesis	http://purl.obolibrary.org/obo/HP_0000122		
HP:0002783	biolink:PhenotypicFeature	Recurrent lower respiratory tract infections	An increased susceptibility to lower respiratory tract infections as manifested by a history of recurrent lower respiratory tract infections.	SNOMEDCT_US:448739000|UMLS:C3163798|SNOMEDCT_US:50417007|UMLS:C0585953|UMLS:C0149725	hp.json	Chronic lung infections|Lower respiratory tract infections|Recurrent chest infections	http://purl.obolibrary.org/obo/HP_0002783		
HP:0000125	biolink:PhenotypicFeature	Pelvic kidney	A developmental defect in which a kidney is located in an abnormal anatomic position within the pelvis.	SNOMEDCT_US:56108007|UMLS:C0221209	hp.json	Sacral kidney	http://purl.obolibrary.org/obo/HP_0000125		
HP:0002788	biolink:PhenotypicFeature	Recurrent upper respiratory tract infections	An increased susceptibility to upper respiratory tract infections as manifested by a history of recurrent upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis).	SNOMEDCT_US:195708003|UMLS:C0581381	hp.json	Recurrent URI|Recurrent upper respiratory and lower respiratory infections|Frequent upper respiratory infections|Recurrent upper respiratory infection|Frequent upper respiratory tract infections|Upper respiratory tract infections, recurrent|Upper respiratory tract infections|Recurrent colds|Recurrent upper respiratory infections	http://purl.obolibrary.org/obo/HP_0002788		
HP:0002789	biolink:PhenotypicFeature	Tachypnea	Very rapid breathing.	MSH:D059246|UMLS:C0231835|SNOMEDCT_US:271823003	hp.json	Increased respiratory rate or depth of breathing|Polypnea	http://purl.obolibrary.org/obo/HP_0002789		
HP:0000124	biolink:PhenotypicFeature	Renal tubular dysfunction	Abnormal function of the renal tubule. The basic functional unit of the kidney, the nephron, consists of a renal corpuscle attached to a renal tubule, with roughly 0.8 to 1.5 nephrons per adult kidney. The functions of the renal tubule include reabsorption of water, electrolytes, glucose, and amino acids and secretion of substances such as uric acid.	UMLS:C0151747|SNOMEDCT_US:95568003	hp.json	Renal tubular disease|Renal tubular defect|Abnormal function of filtrating structures in kidney	http://purl.obolibrary.org/obo/HP_0000124		
HP:0002786	biolink:PhenotypicFeature	Tracheobronchomalacia	Weakness of the cartilage in the trachea and the bronchi, resulting in a floppy (non-rigid) airway. Affected persons may have difficulties to maintain patency of the airways.	UMLS:C0340231|SNOMEDCT_US:233788001|MSH:D055089	hp.json		http://purl.obolibrary.org/obo/HP_0002786		
HP:0000127	biolink:PhenotypicFeature	Renal salt wasting	A high concentration of one or more electrolytes in the urine in the presence of low serum concentrations of the electrolyte(s).	UMLS:C1846347	hp.json	Salt wasting|Renal salt-wasting|Salt-wasting|Loss of salt in urine	http://purl.obolibrary.org/obo/HP_0000127		
HP:0000126	biolink:PhenotypicFeature	Hydronephrosis	Severe distention of the kidney with dilation of the renal pelvis and calices.	SNOMEDCT_US:43064006|UMLS:C0020295|Fyler:4502|MSH:D006869	hp.json		http://purl.obolibrary.org/obo/HP_0000126		
HP:0002787	biolink:PhenotypicFeature	Tracheal calcification	Calcification (abnormal deposits of calcium) in the tracheal tissues.	SNOMEDCT_US:81089005|UMLS:C0264324	hp.json	Tracheal calcifications|Calcification of the trachea|Tracheal ectopic calcification	http://purl.obolibrary.org/obo/HP_0002787		
HP:0002780	biolink:PhenotypicFeature	Bronchomalacia	Weakness or softness of the cartilage in the walls of the bronchial tubes.	SNOMEDCT_US:54203008|MSH:D055091|UMLS:C0264353	hp.json		http://purl.obolibrary.org/obo/HP_0002780		
HP:0002781	biolink:PhenotypicFeature	Upper airway obstruction	Increased resistance to the passage of air in the upper airway.	UMLS:C0740852	hp.json	Upper airway obstruction	http://purl.obolibrary.org/obo/HP_0002781		hposlim_core
GO:0005677	biolink:CellularComponent	chromatin silencing complex	Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.		hp.json		http://purl.obolibrary.org/obo/GO_0005677		
GO:0003014	biolink:BiologicalProcess	renal system process	A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).		hp.json	kidney system process|excretory system process	http://purl.obolibrary.org/obo/GO_0003014		goslim_generic
GO:0003013	biolink:BiologicalProcess	circulatory system process	A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.	Wikipedia:Circulatory_system	hp.json		http://purl.obolibrary.org/obo/GO_0003013		goslim_chembl|goslim_generic
GO:0003016	biolink:BiologicalProcess	respiratory system process	A process carried out by the organs or tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.		hp.json	respiratory gaseous exchange	http://purl.obolibrary.org/obo/GO_0003016		goslim_generic
GO:0003015	biolink:BiologicalProcess	heart process	A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.		hp.json	cardiac process	http://purl.obolibrary.org/obo/GO_0003015		
GO:0003010	biolink:BiologicalProcess	voluntary skeletal muscle contraction	A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control.		hp.json		http://purl.obolibrary.org/obo/GO_0003010		
HP:0002757	biolink:PhenotypicFeature	Recurrent fractures	The repeated occurrence of bone fractures (implying an abnormally increased tendency for fracture).	SNOMEDCT_US:5468008|UMLS:C3805574|MSH:D000069076|UMLS:C3806283|UMLS:C0016655|SNOMEDCT_US:134291007|UMLS:C1833752	hp.json	Frequent fractures|Recurrent fractures|Varying degree of multiple fractures|Increased fractures|Multiple fractures|Increased fracture rate|Multiple spontaneous fractures	http://purl.obolibrary.org/obo/HP_0002757		
GO:0003012	biolink:BiologicalProcess	muscle system process	A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.		hp.json	muscle physiological process	http://purl.obolibrary.org/obo/GO_0003012		goslim_drosophila|goslim_generic
HP:0002758	biolink:PhenotypicFeature	Osteoarthritis	Degeneration (wear and tear) of articular cartilage, i.e., of the joint surface. Joint degeneration may be accompanied by osteophytes (bone overgrowth), narrowing of the joint space, regions of sclerosis at the joint surface, or joint deformity.	MSH:D010003|SNOMEDCT_US:396275006|SNOMEDCT_US:225655006|UMLS:C0029408	hp.json	Degenerative joint disease	http://purl.obolibrary.org/obo/HP_0002758		
HP:0002751	biolink:PhenotypicFeature	Kyphoscoliosis	An abnormal curvature of the spine in both a coronal (lateral) and sagittal (back-to-front) plane.	UMLS:C0575158|SNOMEDCT_US:405773007	hp.json		http://purl.obolibrary.org/obo/HP_0002751		
HP:0002752	biolink:PhenotypicFeature	Sparse bone trabeculae		UMLS:C1833324	hp.json		http://purl.obolibrary.org/obo/HP_0002752		
HP:0002750	biolink:PhenotypicFeature	Delayed skeletal maturation	A decreased rate of skeletal maturation. Delayed skeletal maturation can be diagnosed on the basis of an estimation of the bone age from radiographs of specific bones in the human body.	UMLS:C0541764|SNOMEDCT_US:123983008	hp.json	Delayed bone age before puberty|Delayed bone maturation|Retarded ossification|Delayed skeletal development|Skeletal maturation retardation|Retarded bone age|Delayed bone age	http://purl.obolibrary.org/obo/HP_0002750		
HP:0002755	biolink:PhenotypicFeature	obsolete Osteomyelitis due to immunodeficiency			hp.json		http://purl.obolibrary.org/obo/HP_0002755		
HP:0002756	biolink:PhenotypicFeature	Pathologic fracture	A pathologic fracture occurs when a bone breaks in an area that is weakened secondarily to another disease process such as tumor, infection, and certain inherited bone disorders. A pathologic fracture can occur without a degree of trauma required to cause fracture in healthy bone.	SNOMEDCT_US:268029009|SNOMEDCT_US:22640007|MSH:D005598|UMLS:C0016663	hp.json	Pathologic fractures|Spontaneous fracture|Spontaneous fractures	http://purl.obolibrary.org/obo/HP_0002756		
HP:0002753	biolink:PhenotypicFeature	Thin bony cortex	Abnormal thinning of the cortical region of bones.	UMLS:C1833325	hp.json	Thin cortices	http://purl.obolibrary.org/obo/HP_0002753		
HP:0002754	biolink:PhenotypicFeature	Osteomyelitis	Osteomyelitis is an inflammatory process accompanied by bone destruction and caused by an infecting microorganism.	SNOMEDCT_US:60168000|SNOMEDCT_US:111253001|UMLS:C2242472|MSH:D010019|UMLS:C0029443	hp.json	Bone infection	http://purl.obolibrary.org/obo/HP_0002754		
HP:0000107	biolink:PhenotypicFeature	Renal cyst	A fluid filled sac in the kidney.	UMLS:C0022679|MSH:D052177|UMLS:C3887499	hp.json	Renal cysts|Cystic kidney disease|Kidney cyst|Cystic kidneys	http://purl.obolibrary.org/obo/HP_0000107		
HP:0000108	biolink:PhenotypicFeature	Renal corticomedullary cysts	The presence of multiple cysts at the border between the renal cortex and medulla.	UMLS:C1968619	hp.json	Corticomedullary renal cysts|Renal corticomedullary cystic disease	http://purl.obolibrary.org/obo/HP_0000108		
HP:0002762	biolink:PhenotypicFeature	Multiple exostoses	Presence of more than one exostosis. An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage.	UMLS:C0015306|MSH:D005097|SNOMEDCT_US:254044004	hp.json		http://purl.obolibrary.org/obo/HP_0002762		
HP:0002763	biolink:PhenotypicFeature	Abnormal cartilage morphology	Any morphological abnormality of cartilage.	UMLS:C4025680	hp.json	Abnormality of cartilage morphology|Abnormal shape of cartilage	http://purl.obolibrary.org/obo/HP_0002763		
HP:0000100	biolink:PhenotypicFeature	Nephrotic syndrome	Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria. Nephrotic syndrome refers to the constellation of clinical findings that result from severe renal loss of protein, with Proteinuria and hypoalbuminemia, edema, and hyperlipidemia.	UMLS:C0027726|SNOMEDCT_US:52254009|MSH:D009404	hp.json	Nephrosis	http://purl.obolibrary.org/obo/HP_0000100		
HP:0002761	biolink:PhenotypicFeature	Generalized joint laxity	Joint hypermobility (ability of a joint to move beyond its normal range of motion) affecting many or all joints of the body.	UMLS:C1836308	hp.json	Joint laxity, generalized|Joint laxity, generalised|Generalised joint laxity|Hypermobility of all joints	http://purl.obolibrary.org/obo/HP_0002761		
HP:0002766	biolink:PhenotypicFeature	Relatively short spine		UMLS:C3277114	hp.json	Relatively short spine	http://purl.obolibrary.org/obo/HP_0002766		
HP:0000103	biolink:PhenotypicFeature	Polyuria	An increased rate of urine production.	SNOMEDCT_US:28442001|MSH:D011141|UMLS:C0032617|SNOMEDCT_US:56574000|SNOMEDCT_US:718402002	hp.json	Increased urine output	http://purl.obolibrary.org/obo/HP_0000103		
HP:0000105	biolink:PhenotypicFeature	Enlarged kidney	An abnormal increase in the size of the kidney.	SNOMEDCT_US:300444006|UMLS:C0542518	hp.json	Enlarged kidney|Large kidney|Nephromegaly|Large kidneys|Renal enlargement	http://purl.obolibrary.org/obo/HP_0000105		
HP:0002764	biolink:PhenotypicFeature	Stippled chondral calcification	Punctate (speckled, dot-like) deposition of calcium of calcium salts in the articular cartilage (cartilage located in joints).	UMLS:C4025679	hp.json		http://purl.obolibrary.org/obo/HP_0002764		
HP:0000104	biolink:PhenotypicFeature	Renal agenesis	Agenesis, that is, failure of the kidney to develop during embryogenesis and development.	SNOMEDCT_US:204942005|Fyler:4503|UMLS:C0542519	hp.json	Missing kidney|Renal aplasia|Absent kidney	http://purl.obolibrary.org/obo/HP_0000104		
HP:0012143	biolink:PhenotypicFeature	Abnormal megakaryocyte morphology	Any structural anomaly of megakaryocytes. Mature blood platelets are released from the cytoplasm of megakaryocytes, which are bone-marrow resident cells.	UMLS:C4023026	hp.json	Abnormality of cells of the megakaryocyte lineage	http://purl.obolibrary.org/obo/HP_0012143		
HP:0012144	biolink:PhenotypicFeature	Abnormal monocyte morphology	Any structural anomaly of a myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.	UMLS:C4023025	hp.json		http://purl.obolibrary.org/obo/HP_0012144		
HP:0012145	biolink:PhenotypicFeature	Abnormality of multiple cell lineages in the bone marrow		UMLS:C4023024	hp.json		http://purl.obolibrary.org/obo/HP_0012145		
HP:0012146	biolink:PhenotypicFeature	Abnormality of von Willebrand factor	Decreased quantity or activity of von Willebrand factor. Von Willebrand factor mediates the adhesion of platelets to the collagen exposed on endothelial cell surfaces.	UMLS:C4023023	hp.json		http://purl.obolibrary.org/obo/HP_0012146		
HP:0012147	biolink:PhenotypicFeature	Reduced quantity of Von Willebrand factor	Decreased quantity of von Willebrand factor.	UMLS:C1841816|UMLS:C4023022	hp.json	Decreased von Willebrand factor	http://purl.obolibrary.org/obo/HP_0012147		
HP:0012148	biolink:PhenotypicFeature	Multiple lineage myelodysplasia	Myelodysplasia with dysplastic changes in two or more of the myeloid lineages: erythroid, granulocytic, megakaryocytic.	UMLS:C4023021	hp.json		http://purl.obolibrary.org/obo/HP_0012148		
HP:0012149	biolink:PhenotypicFeature	Bilineage myelodysplasia	Myelodysplasia with dysplastic changes in two of the myeloid lineages: erythroid, granulocytic, megakaryocytic.	UMLS:C4023020	hp.json		http://purl.obolibrary.org/obo/HP_0012149		
HP:0012140	biolink:PhenotypicFeature	obsolete Abnormality of cells of the lymphoid lineage			hp.json		http://purl.obolibrary.org/obo/HP_0012140		
HP:0012142	biolink:PhenotypicFeature	Pancreatic squamous cell carcinoma	A subtype of ductal pancreatic carcinoma that is thought to originate from squamous metaplasia of pancreatic ductal epithelium.	UMLS:C2675993	hp.json	Squamous cell carcinoma of the pancreas	http://purl.obolibrary.org/obo/HP_0012142		
HP:0000154	biolink:PhenotypicFeature	Wide mouth	Distance between the oral commissures more than 2 SD above the mean. Alternatively, an apparently increased width of the oral aperture (subjective).	SNOMEDCT_US:40159009|MSH:D008265|UMLS:C0024433	hp.json	Large oral aperture|Macrostomia|Wide mouth|Broad mouth|Large mouth	http://purl.obolibrary.org/obo/HP_0000154		hposlim_core
HP:0000153	biolink:PhenotypicFeature	Abnormality of the mouth	An abnormality of the mouth.	MSH:D009056|SNOMEDCT_US:128334002|UMLS:C0026633	hp.json	Abnormal mouth|Abnormality of the mouth	http://purl.obolibrary.org/obo/HP_0000153		hposlim_core
HP:0000155	biolink:PhenotypicFeature	Oral ulcer	Erosion of the mucous mebrane of the mouth with local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue.	SNOMEDCT_US:26284000|UMLS:C0149745|MSH:D019226	hp.json	Mouth ulcer|Mouth sore|Oral mucosal ulceration	http://purl.obolibrary.org/obo/HP_0000155		hposlim_core
HP:0000158	biolink:PhenotypicFeature	Macroglossia	Increased length and width of the tongue.	MSH:D008260|SNOMEDCT_US:25273001|UMLS:C0024421	hp.json	Hypertrophy of the tongue|Lingual hypertrophy|Increased size of tongue|Tongue hypertrophy|Large tongue|Glossal hypertrophy|Hyperplasia of the tongue|Abnormally large tongue|Lingual hyperplasia	http://purl.obolibrary.org/obo/HP_0000158		hposlim_core
HP:0000157	biolink:PhenotypicFeature	Abnormality of the tongue	Any abnormality of the tongue.	UMLS:C0878638	hp.json	Abnormality of the tongue|Glossal abnormality|Tongue abnormality|Abnormal tongue|Lingual abnormality	http://purl.obolibrary.org/obo/HP_0000157		hposlim_core
HP:0000159	biolink:PhenotypicFeature	Abnormal lip morphology	An abnormality of the lip.	UMLS:C2183966	hp.json	Anomaly of lip|Lip abnormality|Malformation of lip|Deformity of lip|Abnormal lip|Abnormality of the lip	http://purl.obolibrary.org/obo/HP_0000159		
HP:0000150	biolink:PhenotypicFeature	Gonadoblastoma	The presence of a gonadoblastoma, a neoplasm of a gonad that consists of aggregates of germ cells and sex cord elements.	SNOMEDCT_US:74751003|UMLS:C0206661|MSH:D018238|NCIT:C3754	hp.json		http://purl.obolibrary.org/obo/HP_0000150		
HP:0000152	biolink:PhenotypicFeature	Abnormality of head or neck	An abnormality of head and neck.	UMLS:C4021817	hp.json	Head and neck abnormality|Abnormality of head or neck	http://purl.obolibrary.org/obo/HP_0000152		
HP:0000151	biolink:PhenotypicFeature	Aplasia of the uterus	Aplasia of the uterus.	UMLS:C0425913|SNOMEDCT_US:248942000	hp.json	uterus absent|Absent uterus	http://purl.obolibrary.org/obo/HP_0000151		
HP:0012132	biolink:PhenotypicFeature	Erythroid hyperplasia	Increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.	UMLS:C1838111|UMLS:C0014800|UMLS:C3552917	hp.json	Bone marrow biopsy shows erythroid hyperplasia|Bone marrow smear shows erythroid hyperplasia	http://purl.obolibrary.org/obo/HP_0012132		
GO:0003007	biolink:BiologicalProcess	heart morphogenesis	The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.		hp.json	cardiac morphogenesis	http://purl.obolibrary.org/obo/GO_0003007		
HP:0012133	biolink:PhenotypicFeature	Erythroid hypoplasia	Decreased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.	UMLS:C0542035|SNOMEDCT_US:41614006|MSH:D000741|UMLS:C0178416|SNOMEDCT_US:167923006	hp.json	Erythroblastopenia|Erythroid hypoplasia in the bone marrow	http://purl.obolibrary.org/obo/HP_0012133		
GO:0003006	biolink:BiologicalProcess	developmental process involved in reproduction	A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring.		hp.json	puberty|reproductive developmental process	http://purl.obolibrary.org/obo/GO_0003006		
GO:0003009	biolink:BiologicalProcess	skeletal muscle contraction	A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.		hp.json		http://purl.obolibrary.org/obo/GO_0003009		
HP:0012134	biolink:PhenotypicFeature	Dysplastic erythropoesis		UMLS:C4023032	hp.json		http://purl.obolibrary.org/obo/HP_0012134		
GO:0003008	biolink:BiologicalProcess	system process	A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.		hp.json	organ system process	http://purl.obolibrary.org/obo/GO_0003008		
HP:0012135	biolink:PhenotypicFeature	Abnormal granulocytopoietic cell morphology	An anomaly of cells involved in the formation of a granulocytes, that is, of the granulocytopoietic cell.	UMLS:C4023031	hp.json	Abnormality of cells of the granulocytic lineage	http://purl.obolibrary.org/obo/HP_0012135		
HP:0012136	biolink:PhenotypicFeature	Dysplastic granulopoesis		UMLS:C4023030	hp.json		http://purl.obolibrary.org/obo/HP_0012136		
HP:0012137	biolink:PhenotypicFeature	Abnormal number of granulocyte precursors		UMLS:C4023029	hp.json		http://purl.obolibrary.org/obo/HP_0012137		
GO:0003002	biolink:BiologicalProcess	regionalization	The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.		hp.json	pattern formation	http://purl.obolibrary.org/obo/GO_0003002		
HP:0012138	biolink:PhenotypicFeature	Granulocytic hyperplasia		UMLS:C4023028	hp.json		http://purl.obolibrary.org/obo/HP_0012138		
HP:0012139	biolink:PhenotypicFeature	Granulocytic hypoplasia	Decreased number of granulocyte precursors in the bone marrow.	UMLS:C1534864|SNOMEDCT_US:416627004	hp.json		http://purl.obolibrary.org/obo/HP_0012139		
HP:0012130	biolink:PhenotypicFeature	Abnormal erythroid lineage cell morphology	An anomaly of erythroid lineage cells, that is, of the erythropoietic cells in the lineage leading to and including erythrocytes.	UMLS:C4020862	hp.json	Abnormality of cells of the erythroid lineage	http://purl.obolibrary.org/obo/HP_0012130		
HP:0012131	biolink:PhenotypicFeature	Abnormal number of erythroid precursors	A deviation from the normal count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow.	UMLS:C4023033	hp.json		http://purl.obolibrary.org/obo/HP_0012131		
HP:0000164	biolink:PhenotypicFeature	Abnormality of the dentition	Any abnormality of the teeth.	MSH:D014071|UMLS:C0262444|SNOMEDCT_US:422775003|UMLS:C0040427	hp.json	Abnormal dentition|Dental problem|Dental abnormalities|Dental abnormality|Tooth abnormalities|Abnormality of the teeth|Abnormal teeth|Dental problems|Dental anomalies	http://purl.obolibrary.org/obo/HP_0000164		hposlim_core
HP:0000166	biolink:PhenotypicFeature	Severe periodontitis	A severe form of periodontitis.	UMLS:C4025886	hp.json	Severe pyorrhea|Severe gum disease|Severe periodontal disease	http://purl.obolibrary.org/obo/HP_0000166		
HP:0000169	biolink:PhenotypicFeature	Gingival fibromatosis	The presence of fibrosis of the gingiva.	SNOMEDCT_US:109620006|MSH:D005351|UMLS:C0399440|NCIT:C3041|SNOMEDCT_US:58569000|MSH:C562884|UMLS:C4280677|UMLS:C0016049	hp.json	Gingival fibrous nodules|Hereditary gingival fibromatosis|Idiopathic gingival hyperplasia|Gingival fibroma	http://purl.obolibrary.org/obo/HP_0000169		hposlim_core
HP:0000168	biolink:PhenotypicFeature	Abnormality of the gingiva	Any abnormality of the gingiva (also known as gums).	UMLS:C4021816	hp.json	Gingival abnormality|Abnormality of the gums	http://purl.obolibrary.org/obo/HP_0000168		hposlim_core
HP:0000161	biolink:PhenotypicFeature	Median cleft lip	A type of cleft lip presenting as a midline (median) gap in the upper lip.	UMLS:C1850256	hp.json	Central cleft upper lip|Midline cleft lip	http://purl.obolibrary.org/obo/HP_0000161		hposlim_core
HP:0000160	biolink:PhenotypicFeature	Narrow mouth	Distance between the commissures of the mouth more than 2 SD below the mean. Alternatively, an apparently decreased width of the oral aperture (subjective).	SNOMEDCT_US:14582003|MSH:D008865|UMLS:C0026034	hp.json	Microstomia|Small oral aperture|Narrow mouth|Small mouth	http://purl.obolibrary.org/obo/HP_0000160		hposlim_core
HP:0000163	biolink:PhenotypicFeature	Abnormal oral cavity morphology	Abnormality of the oral cavity, i.e., the opening or hollow part of the mouth.	UMLS:C4025887	hp.json	Abnormality of the oral cavity	http://purl.obolibrary.org/obo/HP_0000163		
HP:0000162	biolink:PhenotypicFeature	Glossoptosis	Posterior displacement of the tongue into the pharynx, i.e., a tongue that is mislocalised posteriorly.	MSH:D065710|SNOMEDCT_US:3639002|UMLS:C0267048|UMLS:C4280678	hp.json	Posterior displacement of the tongue|Retraction of the tongue|Lingual retraction	http://purl.obolibrary.org/obo/HP_0000162		hposlim_core
HP:0012121	biolink:PhenotypicFeature	Panuveitis	Inflammation of the uveal tract in which inflammation affects the anterior chamber, vitreous, retina or choroid.	SNOMEDCT_US:75614007|MSH:D015864|UMLS:C0030343	hp.json		http://purl.obolibrary.org/obo/HP_0012121		
HP:0012122	biolink:PhenotypicFeature	Anterior uveitis	Inflammation of the uveal tract in which the primary site of inflammation is the anterior chamber.	SNOMEDCT_US:4927003|UMLS:C0701807	hp.json		http://purl.obolibrary.org/obo/HP_0012122		
HP:0012123	biolink:PhenotypicFeature	Posterior uveitis	Inflammation of the uveal tract in which the primary site of inflammation is the retina or choroid.	UMLS:C0008526|MSH:D002833|MSH:D015866|UMLS:C0042167|SNOMEDCT_US:43363007|SNOMEDCT_US:16553002	hp.json	Choroiditis	http://purl.obolibrary.org/obo/HP_0012123		
GO:0005635	biolink:CellularComponent	nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).	Wikipedia:Nuclear_envelope	hp.json		http://purl.obolibrary.org/obo/GO_0005635		goslim_generic|goslim_plant|goslim_chembl
HP:0012124	biolink:PhenotypicFeature	Intermediate uveitis	Inflammation of the uveal tract in which the primary site of inflammation is the vitreous.	MSH:D015867|SNOMEDCT_US:314429009|UMLS:C0042166	hp.json		http://purl.obolibrary.org/obo/HP_0012124		
HP:0012125	biolink:PhenotypicFeature	Prostate cancer	A cancer of the prostate.	MSH:D011471|SNOMEDCT_US:399068003|UMLS:C0376358	hp.json	Prostatic cancer	http://purl.obolibrary.org/obo/HP_0012125		
GO:0005634	biolink:CellularComponent	nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	NIF_Subcellular:sao1702920020|Wikipedia:Cell_nucleus	hp.json	horsetail nucleus|cell nucleus	http://purl.obolibrary.org/obo/GO_0005634		goslim_generic|goslim_yeast|goslim_agr|goslim_candida|goslim_plant|goslim_pir|goslim_flybase_ribbon|goslim_drosophila|goslim_aspergillus|goslim_metagenomics|goslim_chembl|goslim_mouse
HP:0012126	biolink:PhenotypicFeature	Stomach cancer	A cancer arising in any part of the stomach.	UMLS:C0699791|SNOMEDCT_US:372143007	hp.json	Gastric cancer	http://purl.obolibrary.org/obo/HP_0012126		
HP:0012127	biolink:PhenotypicFeature	Uraciluria	Increased concentration of uracil in the urine.	UMLS:C4021833	hp.json	High urine uracil levels	http://purl.obolibrary.org/obo/HP_0012127		
HP:0012128	biolink:PhenotypicFeature	Basal ganglia necrosis	Death of cells in the basal ganglia.	UMLS:C4023035	hp.json		http://purl.obolibrary.org/obo/HP_0012128		
HP:0000139	biolink:PhenotypicFeature	Uterine prolapse	The presence of prolapse of the uterus.	MSH:D014596|UMLS:C0042140|SNOMEDCT_US:24976005	hp.json	Sagging uterus	http://purl.obolibrary.org/obo/HP_0000139		
HP:0012120	biolink:PhenotypicFeature	Methylmalonic aciduria	Increased concentration of methylmalonic acid in the urine.	MSH:C537358|UMLS:C1855119	hp.json	High blood methylmalonic acid levels|Methymalonicaciduria	http://purl.obolibrary.org/obo/HP_0012120		
HP:0000132	biolink:PhenotypicFeature	Menorrhagia	Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days.	UMLS:C0025323|MSH:D008595|SNOMEDCT_US:386692008	hp.json	Hypermenorrhea|Abnormally heavy periods|Abnormally heavy bleeding during menstruation	http://purl.obolibrary.org/obo/HP_0000132		
HP:0002795	biolink:PhenotypicFeature	Abnormal respiratory system physiology		Fyler:4200|UMLS:C4025677	hp.json	Functional respiratory abnormality|Impaired pulmonary function|Abnormal respiration|Respiratory problem	http://purl.obolibrary.org/obo/HP_0002795		
HP:0000131	biolink:PhenotypicFeature	Uterine leiomyoma	The presence of a leiomyoma of the uterus.	NCIT:C3157|SNOMEDCT_US:44598004|SNOMEDCT_US:95315005|SNOMEDCT_US:146801000119103|MSH:D007889|UMLS:C0042133	hp.json	Benign uterine leiomyomas|Uterine fibroid	http://purl.obolibrary.org/obo/HP_0000131		
HP:0000134	biolink:PhenotypicFeature	Female hypogonadism	Decreased functionality of the female gonads, i.e., of the ovary.	SNOMEDCT_US:16041008|UMLS:C0271578	hp.json	Hypogonadism, female	http://purl.obolibrary.org/obo/HP_0000134		
HP:0002793	biolink:PhenotypicFeature	Abnormal pattern of respiration	An anomaly of the rhythm or depth of breathing.	UMLS:C1837388	hp.json	Abnormal respiratory patterns|Abnormal pattern of respiration|Unusual breathing patterns	http://purl.obolibrary.org/obo/HP_0002793		
HP:0000133	biolink:PhenotypicFeature	Gonadal dysgenesis		UMLS:C0687149|SNOMEDCT_US:38804009|SNOMEDCT_US:205681004|SNOMEDCT_US:83579008|UMLS:C0018055|MSH:D006060|UMLS:C0018051|MSH:D006059|SNOMEDCT_US:95219002	hp.json	Mixed gonadal dysgenesis|Pure gonadal dysgenesis	http://purl.obolibrary.org/obo/HP_0000133		
HP:0000136	biolink:PhenotypicFeature	Bifid uterus	The presence of a bifid uterus.	UMLS:C1850327	hp.json		http://purl.obolibrary.org/obo/HP_0000136		
HP:0000135	biolink:PhenotypicFeature	Hypogonadism	A decreased functionality of the gonad.	UMLS:C0020619|SNOMEDCT_US:48130008|MSH:D007006	hp.json	Decreased activity of gonads	http://purl.obolibrary.org/obo/HP_0000135		
HP:0002797	biolink:PhenotypicFeature	Osteolysis	Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium.	MSH:D010014|UMLS:C0221204|SNOMEDCT_US:30425001|SNOMEDCT_US:203522001	hp.json	Breakdown of bone|Increased bone resorption|Osteolytic defects of bones	http://purl.obolibrary.org/obo/HP_0002797		
HP:0000138	biolink:PhenotypicFeature	Ovarian cyst	The presence of one or more cysts of the ovary.	SNOMEDCT_US:79883001|MSH:D010048|UMLS:C0029927	hp.json	Ovarian cystic abnormality|Cystic abnormalities of the ovaries|Cystic ovaries|Ovarian cyst	http://purl.obolibrary.org/obo/HP_0000138		
HP:0000137	biolink:PhenotypicFeature	Abnormality of the ovary	An abnormality of the ovary.	MSH:D010049|SNOMEDCT_US:5552004|UMLS:C0029928|UMLS:C4021818	hp.json	Ovarian disease|Abnormality of the ovary|Abnormality of the ovaries	http://purl.obolibrary.org/obo/HP_0000137		
HP:0012129	biolink:PhenotypicFeature	Abnormality of bone marrow stromal cells		UMLS:C4023034	hp.json		http://purl.obolibrary.org/obo/HP_0012129		
HP:0002791	biolink:PhenotypicFeature	Hypoventilation	A reduction in the amount of air transported into the pulmonary alveoli by breathing, leading to hypercapnia (increase in the partial pressure of carbon dioxide).	MSH:D007040|UMLS:C0235063|SNOMEDCT_US:31515003|UMLS:C3203358|SNOMEDCT_US:15993004|MSH:D012131|SNOMEDCT_US:80954004	hp.json	Respiratory depression|Alveolar hypoventilation|Under breathing|Slow breathing	http://purl.obolibrary.org/obo/HP_0002791		
HP:0002792	biolink:PhenotypicFeature	Reduced vital capacity	An abnormal reduction on the vital capacity, which is defined as the total lung capacity (volume of air in the lungs at maximal inflation) less the residual volume (i.e., volume of air in the lungs following maximal exhalation) of the lung.	SNOMEDCT_US:274715008|UMLS:C0476408|SNOMEDCT_US:607007|UMLS:C0520831	hp.json	Decreased vital capacity	http://purl.obolibrary.org/obo/HP_0002792		
HP:0000130	biolink:PhenotypicFeature	Abnormality of the uterus	An abnormality of the uterus.	UMLS:C0266383|SNOMEDCT_US:37849005|MSH:C562565	hp.json	Uterine malformations|Uterine abnormalities|Abnormality of the uterus	http://purl.obolibrary.org/obo/HP_0000130		
HP:0002790	biolink:PhenotypicFeature	Neonatal breathing dysregulation		UMLS:C3806216	hp.json	Impaired breathing in newborn	http://purl.obolibrary.org/obo/HP_0002790		
HP:0012110	biolink:PhenotypicFeature	Hypoplasia of the pons	Underdevelopment of the pons.	UMLS:C1848529	hp.json	Pontine hypoplasia	http://purl.obolibrary.org/obo/HP_0012110		
HP:0012111	biolink:PhenotypicFeature	Abnormality of circulating glucocorticoid level	An abnormality of the concentration of a glucocorticoid in the blood.	UMLS:C4023038	hp.json		http://purl.obolibrary.org/obo/HP_0012111		
HP:0012112	biolink:PhenotypicFeature	Abnormal circulating corticosterone level	An abnormality of the concentration of corticosterone in the blood.	UMLS:C4023037	hp.json	Abnormality of circulating corticosterone level	http://purl.obolibrary.org/obo/HP_0012112		
HP:0012113	biolink:PhenotypicFeature	Abnormal circulating creatine concentration	A deviation from the normal concentration of creatine in the blood circulation. Creatine is a derivative of glycine having methyl and amidino groups attached to the nitrogen. Creatine is naturally produced from amino acids, primarily in liver and kidney, and acts as an energy source for cells, primarly for muscle cells.	UMLS:C4020731	hp.json	Abnormality of creatine metabolism|Creatine metabolism abnormal	http://purl.obolibrary.org/obo/HP_0012113		
HP:0012114	biolink:PhenotypicFeature	Endometrial carcinoma	A carcinoma of the endometrium, the mucous lining of the uterus.	SNOMEDCT_US:254878006|UMLS:C0476089|MSH:D016889	hp.json		http://purl.obolibrary.org/obo/HP_0012114		
HP:0012115	biolink:PhenotypicFeature	Hepatitis	Inflammation of the liver.	SNOMEDCT_US:128241005|UMLS:C0019158|MSH:D006505	hp.json	Liver inflammation	http://purl.obolibrary.org/obo/HP_0012115		
HP:0012116	biolink:PhenotypicFeature	Abnormal circulating albumin concentration	Deviation from normal concentration of albumin in the blood.	UMLS:C4023036	hp.json	Abnormal albumin level	http://purl.obolibrary.org/obo/HP_0012116		
HP:0012117	biolink:PhenotypicFeature	Hyperalbuminemia	Elevation in the concentration of albumin in the blood.	UMLS:C1142113|SNOMEDCT_US:119248009	hp.json	Hyperalbuminaemia|High blood albumin levels|High albumin	http://purl.obolibrary.org/obo/HP_0012117		
GO:0005640	biolink:CellularComponent	nuclear outer membrane	The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.	NIF_Subcellular:sao1617136075	hp.json	perinuclear membrane|nucleus outer envelope	http://purl.obolibrary.org/obo/GO_0005640		
HP:0000143	biolink:PhenotypicFeature	Rectovaginal fistula	The presence of a fistula between the vagina and the rectum.	SNOMEDCT_US:65619001|MSH:D012006|UMLS:C0034895|MEDDRA:10051097	hp.json	Abnormal connection between rectum and vagina	http://purl.obolibrary.org/obo/HP_0000143		hposlim_core
HP:0000142	biolink:PhenotypicFeature	Abnormal vagina morphology	Any structural abnormality of the vagina.	UMLS:C1856023	hp.json	Vaginal malformation	http://purl.obolibrary.org/obo/HP_0000142		
HP:0000145	biolink:PhenotypicFeature	Transverse vaginal septum		UMLS:C1856006	hp.json	Transverse vaginal membrane	http://purl.obolibrary.org/obo/HP_0000145		
HP:0000144	biolink:PhenotypicFeature	Decreased fertility		SNOMEDCT_US:17276009|UMLS:C0520927	hp.json	Decreased fertility|Abnormal fertility	http://purl.obolibrary.org/obo/HP_0000144		
HP:0000147	biolink:PhenotypicFeature	Polycystic ovaries		MSH:D011085|SNOMEDCT_US:69878008|UMLS:C0032460|UMLS:C1136382	hp.json	Sclerocystic ovaries|Polycystic ovary disease|Polycystic ovary	http://purl.obolibrary.org/obo/HP_0000147		
HP:0000149	biolink:PhenotypicFeature	Ovarian gonadoblastoma	The presence of a gonadoblastoma of the ovary.	UMLS:C1518716|SNOMEDCT_US:716594002|NCIT:C3754	hp.json	Gonadoblastoma, female	http://purl.obolibrary.org/obo/HP_0000149		
HP:0000148	biolink:PhenotypicFeature	Vaginal atresia	Congenital occlusion of the vagina or adhesion of the walls of the vagina causing occlusion.	SNOMEDCT_US:87380008|UMLS:C1321884	hp.json	Abnormally closed or absent vagina	http://purl.obolibrary.org/obo/HP_0000148		
HP:0012118	biolink:PhenotypicFeature	Laryngeal carcinoma	A carcinoma of the larynx.	SNOMEDCT_US:276975007|UMLS:C0595989	hp.json	Cancer of the larynx|Laryngeal cancer	http://purl.obolibrary.org/obo/HP_0012118		
HP:0012119	biolink:PhenotypicFeature	Methemoglobinemia	Abnormally increased levels of methemoglobin in the blood. In this form of hemoglobin, there is an oxidized ferric iron (Fe +3) rather than the reduced ferrous form (Fe 2+) that is normally found in hemoglobin. Methemoglobin has a reduced affinity for oxygen, resulting in a reduced ability to release oxygen to tissues.	SNOMEDCT_US:38959009|SNOMEDCT_US:131171006|MSH:D008708|UMLS:C0025637	hp.json		http://purl.obolibrary.org/obo/HP_0012119		
HP:0000141	biolink:PhenotypicFeature	Amenorrhea	Absence of menses for an interval of time equivalent to a total of more than (or equal to) 3 previous cycles or 6 months.	UMLS:C2219717	hp.json	Abnormal absence of menstruation	http://purl.obolibrary.org/obo/HP_0000141		
HP:0000140	biolink:PhenotypicFeature	Abnormality of the menstrual cycle	An abnormality of the ovulation cycle.	UMLS:C4025888|UMLS:C3549779	hp.json	Abnormality of the menstrual cycle|Menstrual abnormalities	http://purl.obolibrary.org/obo/HP_0000140		
CL:0000806	biolink:Cell	DN2 thymocyte	A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive.		hp.json	TN2 cell|DN2 cell|DN2 immature T cell|preT.DN2.Th|DN2 alpha-beta immature T-cell|TN2 thymocyte|double negative 2|DN2 alpha-beta immature T lymphocyte|DN2 alpha-beta immature T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000806		
CL:0000807	biolink:Cell	DN3 thymocyte	A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain.		hp.json	DN3 immature T cell|DN3 cell|TN3 cell|TN3 thymocyte|double negative 3|preT.DN3.Th|DN3 alpha-beta immature T-cell|DN3 alpha-beta immature T lymphocyte|early cortical thymocyte|DN3 alpha-beta immature T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000807		
CL:0000808	biolink:Cell	DN4 thymocyte	A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.		hp.json	DN4 immature T cell|DN4 immature T-cell|DN4 cell|double negative 4|DN4 alpha-beta immature T lymphocyte|early cortical thymocyte|T.DN4.th|DN4 alpha-beta immature T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000808		
CL:0000809	biolink:Cell	double-positive, alpha-beta thymocyte	A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors.		hp.json	late cortical thymocyte|DP thymocyte|double-positive, alpha-beta immature T lymphocyte|DP cell	http://purl.obolibrary.org/obo/CL_0000809		
HP:0002936	biolink:PhenotypicFeature	Distal sensory impairment	An abnormal reduction in sensation in the distal portions of the extremities.	UMLS:C1847584	hp.json	Decreased sensation in extremities|Distal sensory impairment in lower limbs|Loss of distal sensation|Decreased distal sensation|Distal sensory loss, upper and lower limbs|Distal sensation loss|Distal sensory loss|Distal sensory impairment of the lower extremities	http://purl.obolibrary.org/obo/HP_0002936		
HP:0002933	biolink:PhenotypicFeature	Ventral hernia	Ventral hernia refers to a condition in which abdominal contents protrude through a weakened portion of the abdominal wall.	MSH:D006555|UMLS:C0019326|SNOMEDCT_US:414396006	hp.json		http://purl.obolibrary.org/obo/HP_0002933		
HP:0002937	biolink:PhenotypicFeature	Hemivertebrae	Absence of one half of the vertebral body.	UMLS:C0265677|SNOMEDCT_US:68359008	hp.json	Missing part of vertebrae|Hemi-vertebrae|Hemivertebra	http://purl.obolibrary.org/obo/HP_0002937		hposlim_core
CL:0000805	biolink:Cell	immature single positive thymocyte	A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive.		hp.json	immature single positive T lymphocyte|immature single positive T-lymphocyte|ISP|T.ISP.th|immature single positive T cell	http://purl.obolibrary.org/obo/CL_0000805		
HP:0002938	biolink:PhenotypicFeature	Lumbar hyperlordosis	An abnormal accentuation of the inward curvature of the spine in the lumbar region.	UMLS:C1184923	hp.json	Excessive inward curvature of lower spine|Prominent lumbar lordosis|Increased lumbar lordosis|Lumbar lordosis|Exaggerated lumbar lordosis	http://purl.obolibrary.org/obo/HP_0002938		
HP:0002932	biolink:PhenotypicFeature	Aldehyde oxidase deficiency	A reduction in aldehyde oxidase level.	SNOMEDCT_US:124161002|UMLS:C1291266	hp.json		http://purl.obolibrary.org/obo/HP_0002932		
HP:0002930	biolink:PhenotypicFeature	Impaired sensitivity to thyroid hormone	Reduced sensitivity of end organs to thyroid hormone characterized by elevated serum levels of free thyroid hormone with nonsuppressed thyroid stimulating hormone.	SNOMEDCT_US:111567006|UMLS:C2940786|SNOMEDCT_US:237559000|SNOMEDCT_US:50375007|SNOMEDCT_US:237560005|MSH:D018382	hp.json	Elevated serum levels of free thyroid hormone with nonsuppressed TSH|Thyroid hormone resistance|End-organ unresponsiveness to thyroid hormone|Thyroid hormone receptor defect|Resistance to thyroid hormone	http://purl.obolibrary.org/obo/HP_0002930		
CL:0000817	biolink:Cell	precursor B cell	A precursor B cell is a B cell with the phenotype CD10-positive.	BTO:0001133|CALOHA:TS-0819	hp.json	pre-B cell	http://purl.obolibrary.org/obo/CL_0000817		
CL:0000818	biolink:Cell	transitional stage B cell	An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen.		hp.json	transitional B cell|transitional stage B-lymphocyte|T1 B cell|T2 B cell|T3 B cell|transitional stage B-cell|transitional stage B lymphocyte	http://purl.obolibrary.org/obo/CL_0000818		
HP:0002946	biolink:PhenotypicFeature	Supernumerary vertebrae		UMLS:C0265681|SNOMEDCT_US:87294007	hp.json		http://purl.obolibrary.org/obo/HP_0002946		
CL:0000810	biolink:Cell	CD4-positive, alpha-beta thymocyte	An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative.		hp.json	CD4-positive, alpha-beta immature T-cell|CD4-positive, alpha-beta immature T lymphocyte|SP CD4 cell|CD4-positive, alpha-beta immature T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000810		
HP:0002947	biolink:PhenotypicFeature	Cervical kyphosis	Exaggerated convexity of the cervical vertebral column, causing the cervical spine to bow outwards and take on a rounded appearance.	UMLS:C0575170|SNOMEDCT_US:298393001	hp.json	Rounded neck	http://purl.obolibrary.org/obo/HP_0002947		
HP:0002944	biolink:PhenotypicFeature	Thoracolumbar scoliosis		UMLS:C0749379	hp.json	Scoliosis, thoracolumbar	http://purl.obolibrary.org/obo/HP_0002944		
CL:0000811	biolink:Cell	CD8-positive, alpha-beta thymocyte	An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative.		hp.json	CD8-positive, alpha-beta immature T-cell|CD8-positive, alpha-beta immature T lymphocyte|CD8-positive, alpha-beta immature T cell|SP CD8 cell|CD8-positive, alpha-beta immature T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000811		
HP:0002945	biolink:PhenotypicFeature	Intervertebral space narrowing	Decreased height of the intervertebral disk.	UMLS:C0263870|SNOMEDCT_US:11301007	hp.json	Narrow intervertebral spaces|Narrow intervertebral disc spaces	http://purl.obolibrary.org/obo/HP_0002945		
CL:0000813	biolink:Cell	memory T cell	A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure.	BTO:0003435	hp.json	memory T-cell|memory T lymphocyte|memory T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000813		
HP:0002948	biolink:PhenotypicFeature	Vertebral fusion	A developmental defect leading to the union of two adjacent vertebrae.	UMLS:C1849073|UMLS:C3278509|UMLS:C1835763	hp.json	Fusion of vertebral bodies|Spinal fusion|Fused vertebrae|Vertebral body fusion	http://purl.obolibrary.org/obo/HP_0002948		hposlim_core
CL:0000815	biolink:Cell	regulatory T cell	A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.	BTO:0004520|FMA:84070	hp.json	suppressor T cell|suppressor T-cell|suppressor T lymphocyte|suppressor T-lymphocyte|regulatory T-cell|regulatory T lymphocyte|Treg|regulatory T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000815		
HP:0002949	biolink:PhenotypicFeature	Fused cervical vertebrae	A congenital anomaly characterized by a joining (fusion) of two or more cervical vertebral bodies with one another.	UMLS:C3887527	hp.json	Cervical vertebral fusion|Fused neck|Fusion of cervical vertebrae|Cervical spine fusion	http://purl.obolibrary.org/obo/HP_0002949		
CL:0000816	biolink:Cell	immature B cell	An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation.		hp.json	newly formed B cell|immature B-cell|immature B lymphocyte|immature B-lymphocyte	http://purl.obolibrary.org/obo/CL_0000816		
HP:0002942	biolink:PhenotypicFeature	Thoracic kyphosis	Over curvature of the thoracic region, leading to a round back or if sever to a hump.	UMLS:C1184919	hp.json	Exaggerated thoracic kyphosis|Accentuated thoracic kyphosis	http://purl.obolibrary.org/obo/HP_0002942		
HP:0002943	biolink:PhenotypicFeature	Thoracic scoliosis		UMLS:C1857790	hp.json		http://purl.obolibrary.org/obo/HP_0002943		
OBO:uberon/core#posteriorly_connected_to	biolink:NamedThing	posteriorly connected to	x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y.		hp.json		http://purl.obolibrary.org/obo/uberon/core#posteriorly_connected_to		
HP:0002919	biolink:PhenotypicFeature	Ketonuria	High levels of ketone bodies (acetoacetic acid, beta-hydroxybutyric acid, and acetone) in the urine. Ketone bodies are insignificant in the blood and urine of normal individuals in the postprandial or overnight-fasted state.	SNOMEDCT_US:274783007|UMLS:C0162275|MSH:D007662|SNOMEDCT_US:36815008	hp.json	Ketoaciduria|Acetonuria|Ketonaciduria|Ketone bodies in urine	http://purl.obolibrary.org/obo/HP_0002919		
HP:0002913	biolink:PhenotypicFeature	Myoglobinuria	Presence of myoglobin in the urine.	UMLS:C0027080|MSH:D009212|SNOMEDCT_US:48165008	hp.json		http://purl.obolibrary.org/obo/HP_0002913		
HP:0002914	biolink:PhenotypicFeature	Hyperchloriduria	An increased concentration of chloride in the urine.	UMLS:C1846352	hp.json	Increased urinary chloride	http://purl.obolibrary.org/obo/HP_0002914		
HP:0002912	biolink:PhenotypicFeature	Methylmalonic acidemia	Increased concentration of methylmalonic acid in the blood.	SNOMEDCT_US:42393006|MSH:C537358|UMLS:C0268583	hp.json	Elevated circulating methylmalonic acid concentration	http://purl.obolibrary.org/obo/HP_0002912		
HP:0002917	biolink:PhenotypicFeature	Hypomagnesemia	An abnormally decreased magnesium concentration in the blood.	SNOMEDCT_US:190855004|UMLS:C0151723	hp.json	Low blood magnesium levels|Low blood Mg levels	http://purl.obolibrary.org/obo/HP_0002917		
HP:0002918	biolink:PhenotypicFeature	Hypermagnesemia	An abnormally increased magnesium concentration in the blood.	SNOMEDCT_US:66978005|UMLS:C0151714	hp.json	High blood magnesium levels|High blood Mg levels	http://purl.obolibrary.org/obo/HP_0002918		
HP:0002916	biolink:PhenotypicFeature	Abnormality of chromosome segregation	An abnormality of chromosome segregation.	UMLS:C4025670	hp.json		http://purl.obolibrary.org/obo/HP_0002916		
HP:0002910	biolink:PhenotypicFeature	Elevated hepatic transaminase	Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage.	UMLS:C0086565|UMLS:C0438717|MSH:D008107|SNOMEDCT_US:166643006|UMLS:C0235996|UMLS:C0877359|UMLS:C1842003|UMLS:C1848701|UMLS:C0438237|SNOMEDCT_US:166603001|UMLS:C0151766|SNOMEDCT_US:75183008	hp.json	Increased liver function tests|Abnormal liver enzymes|Raised liver enzymes|Subclinical abnormal liver function tests|Increased transaminases|Abnormal liver function tests|Increased liver enzymes|Elevated serum transaminases|Abnormal liver function|Elevated liver function tests|Elevated transaminases|Elevated liver enzymes|High liver enzymes	http://purl.obolibrary.org/obo/HP_0002910		
HP:0002924	biolink:PhenotypicFeature	obsolete Decreased circulating aldosterone level			hp.json		http://purl.obolibrary.org/obo/HP_0002924		
HP:0002925	biolink:PhenotypicFeature	Elevated circulating thyroid-stimulating hormone concentration	Increased concentration of thyroid-stimulating hormone (TSH) in the blood circulation.	UMLS:C0586553|SNOMEDCT_US:309080005	hp.json	Elevated thyroid stimulating hormone levels|Increased serum thyroid-stimulating hormone|Elevated thyroid stimulating hormone|Thyroid-stimulating hormone excess|Increased thyroid-stimulating hormone level|Increased thyrotropin level|Increased thyroid-stimulating hormone|TSH excess|High TSH	http://purl.obolibrary.org/obo/HP_0002925		
HP:0002922	biolink:PhenotypicFeature	Increased CSF protein	Increased concentration of protein in the cerebrospinal fluid.	UMLS:C1806780	hp.json	Spinal fluid protein elevated|Hyperproteinorrhachia|Elevated cerebrospinal fluid protein|Cerebrospinal fluid with increased protein|Increased protein in csf|Cerebrospinal fluid protein increased|Elevated csf protein	http://purl.obolibrary.org/obo/HP_0002922		
HP:0002923	biolink:PhenotypicFeature	Rheumatoid factor positive	The presence in the serum of an autoantibody directed against the Fc portion of IgG.	UMLS:C0151379|SNOMEDCT_US:165839004	hp.json		http://purl.obolibrary.org/obo/HP_0002923		
HP:0002928	biolink:PhenotypicFeature	Decreased activity of the pyruvate dehydrogenase complex		UMLS:C1839888	hp.json	Pyruvate dehydrogenase complex deficiency|Decreased activity of the PDH complex	http://purl.obolibrary.org/obo/HP_0002928		
HP:0002929	biolink:PhenotypicFeature	Leydig cell insensitivity to gonadotropin		UMLS:C4025668	hp.json		http://purl.obolibrary.org/obo/HP_0002929		
HP:0002926	biolink:PhenotypicFeature	Abnormality of thyroid physiology	An abnormal functionality of the thyroid gland.	UMLS:C0857576	hp.json	Abnormal thyroid function	http://purl.obolibrary.org/obo/HP_0002926		
HP:0002927	biolink:PhenotypicFeature	Histidinuria	An increased concentration of histidine in the urine.	SNOMEDCT_US:78311009|UMLS:C0268642|MSH:C538321	hp.json	High urine histidine levels|Elevated histidine in urine	http://purl.obolibrary.org/obo/HP_0002927		
HP:0002920	biolink:PhenotypicFeature	Decreased circulating ACTH level	An abnormal reduction in the concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), in the blood.	UMLS:C4025669	hp.json		http://purl.obolibrary.org/obo/HP_0002920		
HP:0002921	biolink:PhenotypicFeature	Abnormality of the cerebrospinal fluid	An abnormality of the cerebrospinal fluid (CSF).	UMLS:C0151583	hp.json	Abnormal CSF findings|Abnormality of the CSF	http://purl.obolibrary.org/obo/HP_0002921		
HP:0012300	biolink:PhenotypicFeature	Ureteral agenesis	Failure of the ureter to undergo development.	UMLS:C4022959	hp.json		http://purl.obolibrary.org/obo/HP_0012300		
HP:0012301	biolink:PhenotypicFeature	Type II transferrin isoform profile	Abnormal transferrin isoform profile consistent with a type II congenital disorder of glycosylation.	UMLS:C4021094	hp.json	Abnormal isoelectric focusing of serum transferrin, type II pattern|Abnormal isoelectric focusing of serum transferrin, type 2 pattern|Isoelectric focusing of serum transferrin consistent with CDG type II|Type 2 transferrin isoform profile	http://purl.obolibrary.org/obo/HP_0012301		
HP:0012302	biolink:PhenotypicFeature	Herpes simplex encephalitis	Infection of the brain parenchyma with herpes simplex virus, resulting in inflammation of the brain parenchyma with neurologic dysfunction.	SNOMEDCT_US:428638009|UMLS:C0276226|MSH:D020803	hp.json	Herpes encephalitis	http://purl.obolibrary.org/obo/HP_0012302		
HP:0012303	biolink:PhenotypicFeature	Abnormal aortic arch morphology	An anomaly of the arch of aorta.	UMLS:C3163801|SNOMEDCT_US:448742006|Fyler:2700	hp.json	Abnormality of the aortic arch	http://purl.obolibrary.org/obo/HP_0012303		
HP:0012304	biolink:PhenotypicFeature	Hypoplastic aortic arch	Underdevelopment of the arch of aorta.	Fyler:2704|SNOMEDCT_US:60787001|UMLS:C0265881	hp.json	Aortic arch hypoplasia|Underdeveloped aortic arch	http://purl.obolibrary.org/obo/HP_0012304		
GO:0003197	biolink:BiologicalProcess	endocardial cushion development	The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.		hp.json		http://purl.obolibrary.org/obo/GO_0003197		
HP:0000316	biolink:PhenotypicFeature	Hypertelorism	Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes).	SNOMEDCT_US:22006008|UMLS:C0020534|SNOMEDCT_US:194021007|MSH:D006972	hp.json	Increased interpupillary distance|Excessive orbital separation|Increased distance between eye sockets|Widened interpupillary distance|Wide-set eyes|Increased distance between eyes|Ocular hypertelorism|Widely spaced eyes	http://purl.obolibrary.org/obo/HP_0000316		hposlim_core
HP:0002979	biolink:PhenotypicFeature	Bowing of the legs	A bending or abnormal curvature affecting a long bone of the leg.	MSH:D056305|SNOMEDCT_US:299331007|UMLS:C0544755	hp.json	Bowed legs|Bow-leggedness|Bowed lower limbs|Bow legs	http://purl.obolibrary.org/obo/HP_0002979		
HP:0000315	biolink:PhenotypicFeature	Abnormality of the orbital region		UMLS:C4025863	hp.json	Abnormality of the eye region|Malformation of the orbital region of the face|Deformity of the orbital region of the face|Anomaly of the orbital region of the face|Abnormality of the region around the eyes	http://purl.obolibrary.org/obo/HP_0000315		
HP:0002977	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the central nervous system	Absence or underdevelopment of tissue in the central nervous system.	UMLS:C4025665	hp.json	Absent/underdeveloped central nervous system tissue|Aplasia/Hypoplasia involving the CNS	http://purl.obolibrary.org/obo/HP_0002977		
HP:0000317	biolink:PhenotypicFeature	Facial myokymia	Facial myokymia is a fine fibrillary activity of one or more muscles innervated by the facial nerve (the seventh cranial nerve).	MSH:D005155|SNOMEDCT_US:1070000|UMLS:C0270871	hp.json	Involuntary facial contraction|Involuntary facial quivering	http://purl.obolibrary.org/obo/HP_0000317		
HP:0000319	biolink:PhenotypicFeature	Smooth philtrum	Flat skin surface, with no ridge formation in the central region of the upper lip between the nasal base and upper vermilion border.	UMLS:C1142533	hp.json	Flat philtrum|Shallow philtrum|Philtrum, smooth|Indistinct philtrum|Simple philtrum|Decreased depth of philtrum	http://purl.obolibrary.org/obo/HP_0000319		
HP:0002971	biolink:PhenotypicFeature	Absent microvilli on the surface of peripheral blood lymphocytes	Absence of the fingerlike protrusive, actin-dependent structures found on the surface of peripheral blood lymphocytes.	UMLS:C1833173	hp.json		http://purl.obolibrary.org/obo/HP_0002971		
HP:0002972	biolink:PhenotypicFeature	Reduced delayed hypersensitivity	Decreased ability to react to a delayed hypersensitivity skin test.	UMLS:C1843386	hp.json	Deficiency of delayed skin hypersensitivity|Impaired delayed hypersensitivity|Decreased reactivity to skin test antigens	http://purl.obolibrary.org/obo/HP_0002972		
HP:0002970	biolink:PhenotypicFeature	Genu varum	A positional abnormality marked by outward bowing of the legs in which the knees stay wide apart when a person stands with the feet and ankles together.	MSH:D056305|SNOMEDCT_US:299331007|UMLS:C0544755	hp.json	Genu vara|Outward bow-leggedness|Outward bowing at knees|Genua vara	http://purl.obolibrary.org/obo/HP_0002970		hposlim_core
HP:0000311	biolink:PhenotypicFeature	Round face	The facial appearance is more circular than usual as viewed from the front.	UMLS:C1856468|UMLS:C0239479	hp.json	Round facial shape|Circular face|Round face|Round facies|Round, full face|Round facial appearance	http://purl.obolibrary.org/obo/HP_0000311		hposlim_core
HP:0002973	biolink:PhenotypicFeature	Abnormal forearm morphology	An abnormality of the lower arm.	UMLS:C4025666	hp.json	Abnormality of the forearm	http://purl.obolibrary.org/obo/HP_0002973		hposlim_core
HP:0002974	biolink:PhenotypicFeature	Radioulnar synostosis	An abnormal osseous union (fusion) between the radius and the ulna.	UMLS:C0158761|MSH:C562408|SNOMEDCT_US:33313004|MEDDRA:10037798	hp.json	Fused forearm bones	http://purl.obolibrary.org/obo/HP_0002974		hposlim_core
HP:0012305	biolink:PhenotypicFeature	Coarctation of the descending aortic arch	Narrowing or constriction of the aorta localized to the region of the descending trunk of arch of aorta.	UMLS:C4022958	hp.json		http://purl.obolibrary.org/obo/HP_0012305		
HP:0012306	biolink:PhenotypicFeature	Abnormal rib ossification	An anomaly of the process of rib bone formation.	UMLS:C4022957	hp.json	Abnormal maturation of rib bones	http://purl.obolibrary.org/obo/HP_0012306		
HP:0012307	biolink:PhenotypicFeature	Spatulate ribs	Ribs that are increased in width and taper to the posterior ends.	UMLS:C1856637	hp.json		http://purl.obolibrary.org/obo/HP_0012307		
HP:0012308	biolink:PhenotypicFeature	Decreased serum complement C9	A reduced level of the complement component C9 in circulation.	UMLS:C4021093	hp.json	Decreased serum C9	http://purl.obolibrary.org/obo/HP_0012308		
HP:0012309	biolink:PhenotypicFeature	Cutaneous amyloidosis	The presence of amyloid deposition in the superficial dermis.	SNOMEDCT_US:281882003|UMLS:C0268397|SNOMEDCT_US:282834007|SNOMEDCT_US:201337008|MSH:C562642|SNOMEDCT_US:718105008	hp.json		http://purl.obolibrary.org/obo/HP_0012309		
HP:0000327	biolink:PhenotypicFeature	Hypoplasia of the maxilla	Abnormally small dimension of the Maxilla. Usually creating a malocclusion or malalignment between the upper and lower teeth or resulting in a deficient amount of projection of the base of the nose and lower midface region.	UMLS:C4280643|UMLS:C4280642|UMLS:C4280641|UMLS:C4280640|UMLS:C4082243|UMLS:C0240310	hp.json	Retrognathia of upper jaw|Decreased size of upper jaw|Retrusion of upper jaw bones|Hypotrophic maxilla|Maxillary retrusion|Micromaxilla|Hypoplastic maxillary bones|Upper jaw retrusion|Small upper jaw|Small upper jaw bones|Maxillary retrognathia|Decreased projection of upper jaw|Decreased size of maxilla|Upper jaw deficiency|Maxillary deficiency|Maxillary hypoplasia|Hypoplasia of upper jaw bones|Deficiency of upper jaw bones|Small maxilla|Hypotrophic upper jaw bones|Maxillary micrognathia|Decreased projection of maxilla	http://purl.obolibrary.org/obo/HP_0000327		hposlim_core
HP:0000326	biolink:PhenotypicFeature	Abnormality of the maxilla	An abnormality of the Maxilla (upper jaw bone).	UMLS:C4025862	hp.json	Deformity of the maxilla|Abnormality of the upper jaw bone|Anomaly of the maxilla|Deformity of the upper jaw bones|Malformation of the upper jaw bones|Abnormality of the upper jaw bones|Malformation of the maxilla	http://purl.obolibrary.org/obo/HP_0000326		hposlim_core
HP:0000329	biolink:PhenotypicFeature	Facial hemangioma	Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the face.	UMLS:C1861443	hp.json	Facial hemangiomata	http://purl.obolibrary.org/obo/HP_0000329		
HP:0002982	biolink:PhenotypicFeature	Tibial bowing	A bending or abnormal curvature of the tibia.	UMLS:C1837081	hp.json	Bowed shankbone|Bowed tibia|Bowed shinbone|Bowing of the tibia	http://purl.obolibrary.org/obo/HP_0002982		hposlim_core
HP:0002983	biolink:PhenotypicFeature	Micromelia	The presence of abnormally small extremities.	SNOMEDCT_US:74370006|UMLS:C0025995|MEDDRA:10027546	hp.json	Smaller or shorter than typical limbs	http://purl.obolibrary.org/obo/HP_0002983		hposlim_core
HP:0000321	biolink:PhenotypicFeature	Square face	Facial contours, as viewed from the front, show a broad upper face/cranium and lower face/mandible, creating a square appearance.	UMLS:C1832127	hp.json	Square facies|Square facial shape|Square face	http://purl.obolibrary.org/obo/HP_0000321		
HP:0002980	biolink:PhenotypicFeature	Femoral bowing	Bowing (abnormal curvature) of the femur.	UMLS:C1859461	hp.json	Bowed femurs|Bowed femura|Bowed thighbone|Bowed femur	http://purl.obolibrary.org/obo/HP_0002980		hposlim_core
HP:0002981	biolink:PhenotypicFeature	Abnormality of the calf	An abnormality of the calf, i.e. of the posterior part of the lower leg.	UMLS:C4021832	hp.json	Abnormality of the calf	http://purl.obolibrary.org/obo/HP_0002981		
HP:0000320	biolink:PhenotypicFeature	Bird-like facies		UMLS:C1837758	hp.json	Bird-like facial appearance	http://purl.obolibrary.org/obo/HP_0000320		
HP:0002986	biolink:PhenotypicFeature	Radial bowing	A bending or abnormal curvature of the radius.	UMLS:C1859399	hp.json	Bowing of outer large bone of the forearm|Bowing of radius bone of the forearm|Bowed radii|Bowed radius	http://purl.obolibrary.org/obo/HP_0002986		hposlim_core
HP:0000322	biolink:PhenotypicFeature	Short philtrum	Distance between nasal base and midline upper lip vermilion border more than 2 SD below the mean. Alternatively, an apparently decreased distance between nasal base and midline upper lip vermilion border.	UMLS:C1861324	hp.json	Decreased height of philtrum|Decreased length of philtrum|Vertical hypoplasia of philtrum|Decreased vertical dimension of philtrum	http://purl.obolibrary.org/obo/HP_0000322		hposlim_core
HP:0002987	biolink:PhenotypicFeature	Elbow flexion contracture	An elbow contracture that limits the ability of the elbow joint to be extended (straightened), meaning that the elbow is fixed in an flexed (bent) position.	UMLS:C0409338|SNOMEDCT_US:202271004	hp.json	Fixed flexion at the elbow joint|Elbow flexion deformity|Elbow flexion contractures	http://purl.obolibrary.org/obo/HP_0002987		
HP:0002984	biolink:PhenotypicFeature	Hypoplasia of the radius	Underdevelopment of the radius.	UMLS:C1840087|UMLS:C0685381|SNOMEDCT_US:93288001|SNOMEDCT_US:205170001	hp.json	Hypoplastic radii|Hypoplastic radius|Short radii|Shortening of radius|Radial ray hypoplasia|Underdeveloped outer large forearm bone|Radial hypoplasia|Short radius	http://purl.obolibrary.org/obo/HP_0002984		hposlim_core
HP:0000325	biolink:PhenotypicFeature	Triangular face	Facial contour, as viewed from the front, triangular in shape, with breadth at the temples and tapering to a narrow chin.	UMLS:C1835884	hp.json	Face with broad temples and narrow chin|Triangular facial shape|Triangular face|Triangular facies	http://purl.obolibrary.org/obo/HP_0000325		hposlim_core
HP:0000324	biolink:PhenotypicFeature	Facial asymmetry	An abnormal difference between the left and right sides of the face.	UMLS:C1306710|SNOMEDCT_US:15253005|MSH:D005146	hp.json	Asymmetry of right and left side of face|Unequal sides of face|Facial asymmetry|Unbalanced face|Uneven face|Unsymmetrical face|Asymmetry of face|Crooked face|Asymmetric facies|Uneven sides of face	http://purl.obolibrary.org/obo/HP_0000324		hposlim_core
HP:0002958	biolink:PhenotypicFeature	Immune dysregulation	Altered immune function characterized by lymphoid proliferation, immune activation, and excessive autoreactivity often leading to autoimmune/inflammatory complications.	UMLS:C1844666	hp.json	Unregulated immune response|Immune dysregulation	http://purl.obolibrary.org/obo/HP_0002958		
HP:0002955	biolink:PhenotypicFeature	Granulomatosis	A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity.	SNOMEDCT_US:44328006|UMLS:C0521173|SNOMEDCT_US:443138004	hp.json		http://purl.obolibrary.org/obo/HP_0002955		
HP:0002959	biolink:PhenotypicFeature	Impaired Ig class switch recombination	An impairment of the class-switch recombination process that normally leads B lymphocytes to produce IgG, IgA, or IgE.	UMLS:C1842528	hp.json	Impaired B-lymphocyte isotype switching	http://purl.obolibrary.org/obo/HP_0002959		
HP:0002953	biolink:PhenotypicFeature	Vertebral compression fracture		UMLS:C0410550|SNOMEDCT_US:42942008|SNOMEDCT_US:84138006|UMLS:C0262431	hp.json	Vertebral body compression|Vertebral compression fractures|Vertebral compression|Vertebral compression or collapse|Vertebral collapse|Compression fracture of a vertebral body|Fractures of vertebral bodies	http://purl.obolibrary.org/obo/HP_0002953		
HP:0002951	biolink:PhenotypicFeature	Partial absence of cerebellar vermis	Congenital absence of a part of the vermis of cerebellum.	UMLS:C4025667	hp.json		http://purl.obolibrary.org/obo/HP_0002951		
HP:0000307	biolink:PhenotypicFeature	Pointed chin	A marked tapering of the lower face to the chin.	UMLS:C1844505	hp.json	Small pointed chin|Pointy chin|Pointed mention region|Pointed chin|Witch's chin	http://purl.obolibrary.org/obo/HP_0000307		hposlim_core
HP:0000306	biolink:PhenotypicFeature	Abnormality of the chin	An abnormality of the chin, i.e., of the inferior portion of the face lying inferior to the lower lip and including the central prominence of the lower jaw.	UMLS:C4025864	hp.json	Abnormality of the menton|Malformation of the chin|Deformity of the chin|Anomaly of the chin|Abnormality of the chin	http://purl.obolibrary.org/obo/HP_0000306		hposlim_core
HP:0002967	biolink:PhenotypicFeature	Cubitus valgus	Abnormal positioning in which the elbows are turned out.	UMLS:C0158465|SNOMEDCT_US:54583007	hp.json	Outward turned elbows	http://purl.obolibrary.org/obo/HP_0002967		hposlim_core
HP:0000309	biolink:PhenotypicFeature	Abnormal midface morphology	An anomaly of the midface, which is a region and not an anatomical term. It extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base. It is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region. Traditionally, the nose and premaxilla are not included in the midface.	UMLS:C4021811	hp.json	Abnormality of the midface|Anomaly of the midface|Abnormal morphology of the midface|Malformation of the midface|Deformity of the midface	http://purl.obolibrary.org/obo/HP_0000309		
HP:0000308	biolink:PhenotypicFeature	Microretrognathia	A form of developmental hypoplasia of the mandible in which the mandible is mislocalised posteriorly.	UMLS:C1839546	hp.json	Retromicrognathia|Small retruded chin	http://purl.obolibrary.org/obo/HP_0000308		
HP:0002960	biolink:PhenotypicFeature	Autoimmunity	The occurrence of an immune reaction against the organism's own cells or tissues.	UMLS:C0004364|MSH:D001327|SNOMEDCT_US:85828009	hp.json	Autoimmune disease|Autoimmune disorder|Autoimmunity|Autoimmune condition	http://purl.obolibrary.org/obo/HP_0002960		
HP:0002961	biolink:PhenotypicFeature	Dysgammaglobulinemia	Selective deficiency of one or more, but not all, classes of immunoglobulins.	UMLS:C0013374|SNOMEDCT_US:123782009|MSH:D004406	hp.json		http://purl.obolibrary.org/obo/HP_0002961		
CHEBI:134179	biolink:ChemicalSubstance	volatile organic compound	Any organic compound having an initial boiling point less than or equal to 250 degreeC (482 degreeF) measured at a standard atmospheric pressure of 101.3 kPa.	Wikipedia:Volatile_organic_compound	hp.json	volatile organic compounds|VOC|VOCs	http://purl.obolibrary.org/obo/CHEBI_134179		3_STAR
HP:0000301	biolink:PhenotypicFeature	Abnormality of facial musculature	An anomaly of a muscle that is innervated by the facial nerve (the seventh cranial nerve).	UMLS:C4025865	hp.json	Abnormality of facial muscles|Facial muscle issue	http://purl.obolibrary.org/obo/HP_0000301		
HP:0000300	biolink:PhenotypicFeature	Oval face	A face with a rounded and slightly elongated outline.	UMLS:C1849025	hp.json	Oval facies|Oval facial shape|Oval face	http://purl.obolibrary.org/obo/HP_0000300		
HP:0002965	biolink:PhenotypicFeature	Cutaneous anergy	Inability to react to a delayed hypersensitivity skin test.	UMLS:C1855781	hp.json	Lack of delayed skin hypersensitivity reaction|Absence of delayed hypersensitivity skin test	http://purl.obolibrary.org/obo/HP_0002965		
HP:0000303	biolink:PhenotypicFeature	Mandibular prognathia	Abnormal prominence of the chin related to increased length of the mandible.	MSH:D008313|UMLS:C4280645|UMLS:C0302501|UMLS:C4280644|SNOMEDCT_US:22810007|UMLS:C2227134|SNOMEDCT_US:109504005|UMLS:C0399526	hp.json	Enlarged mandible|Mandibular excess|Prominent chin|Hypertrophy of lower jaw|Prognathia|Macromandible|Big lower jaw|Increased size of mandible|Prominent jaw|Hyperplasia of lower jaw|Enlargement of mandible|Lower jaw excess|Lower jaw hyperplasia|Prognathism|Large lower jaw|Increased projection of lower jaw|Relative mandibular prognathism|Large mandible|Increased size of lower jaw|Prominent mandible|Hypertrophy of mandible|Mandibular macrognathia|Prominent lower jaw|Mandible prognathism|Mandibular hyperplasia|Mandibular prognathism|Increased projection of mandible|Big mandible	http://purl.obolibrary.org/obo/HP_0000303		hposlim_core
HP:0002963	biolink:PhenotypicFeature	Abnormal delayed hypersensitivity skin test	Delay in cutaneous immune reaction to specific antigens mediated not by antibodies but by cells. The delayed hypersensitivity test is an immune function test measuring the presence of activated T cells that recognize a specific antigen and is performed by injecting a small amount of the antigen into the skin. The area of the injection is examined 48-72 hours thereafter.	UMLS:C1833172	hp.json		http://purl.obolibrary.org/obo/HP_0002963		
GO:0042762	biolink:BiologicalProcess	regulation of sulfur metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur.		hp.json	regulation of sulfur metabolism|regulation of sulphur metabolism|regulation of sulphur metabolic process	http://purl.obolibrary.org/obo/GO_0042762		
CHEBI:17549	biolink:ChemicalSubstance	5-aminolevulinic acid	The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp.	Drug_Central:166|PMID:19378778|PMID:22378066|PMID:7890117|Wikipedia:Aminolevulinic_acid|PMID:23299429|Beilstein:1759139|PMID:23339045|Reaxys:1759139|LINCS:LSM-5677|PMID:23360321|PMID:23242333|KNApSAcK:C00007378|KEGG:C00430|PMID:23307195|PMID:23291627|DrugBank:DB00855|CAS:106-60-5|CAS:106-60-5|HMDB:HMDB0001149|KEGG:D07567|PMID:15996585|PMID:11303952|PMID:22700502|PMID:15756058|PMID:18982627	hp.json	5-amino-4-oxopentanoic acid|dALA|5-Amino-4-oxovaleric acid|delta-ALA|5-ALA|aminolevulinic acid|delta-aminolevulinic acid|5-Amino-4-oxopentanoate|5-Aminolevulinate	http://purl.obolibrary.org/obo/CHEBI_17549		3_STAR
CL:0000881	biolink:Cell	perivascular macrophage	A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+.		hp.json		http://purl.obolibrary.org/obo/CL_0000881		
CHEBI:17544	biolink:ChemicalSubstance	hydrogencarbonate	The carbon oxoanion resulting from the removal of a proton from carbonic acid.	Beilstein:3903504|PMID:28732801|PMID:4208463|MetaCyc:HCO3|PMID:29466234|PMID:18439416|KEGG:C00288|CAS:71-52-3|PMID:29150416|PDBeChem:BCT|Wikipedia:Bicarbonate|PMID:17505962|PMID:17215880|PMID:29460248|Gmelin:49249|HMDB:HMDB0000595	hp.json	hydroxidodioxidocarbonate(1-)|Hydrogencarbonate|hydrogentrioxocarbonate(1-)|hydrogentrioxocarbonate(IV)|hydrogencarbonate(1-)|[CO2(OH)](-)|BICARBONATE ION|hydrogencarbonate|Acid carbonate|hydrogen carbonate|HCO3(-)|hydrogencarbonate|HCO3-|Bicarbonate|hydrogen(trioxidocarbonate)(1-)	http://purl.obolibrary.org/obo/CHEBI_17544		3_STAR
NCBITaxon:39107	biolink:OrganismalEntity	Murinae		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_39107		
CL:0000897	biolink:Cell	CD4-positive, alpha-beta memory T cell	A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell.		hp.json	CD4-positive, alpha-beta memory T-lymphocyte|CD4-positive, alpha-beta memory T-cell|CD4-positive, alpha-beta memory T lymphocyte|T4.Mem.Sp	http://purl.obolibrary.org/obo/CL_0000897		
CL:0000898	biolink:Cell	naive T cell	Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.		hp.json	naive T-cell|naive T lymphocyte|naive T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000898		
CL:0000891	biolink:Cell	foam cell	A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions.	FMA:83586|BTO:0003872	hp.json		http://purl.obolibrary.org/obo/CL_0000891		
CL:0000893	biolink:Cell	thymocyte	An immature T cell located in the thymus.	FMA:72202|BTO:0001372|XAO:0003159|CALOHA:TS-1042	hp.json	thymic lymphocyte|immature T cell|immature T-cell|immature T lymphocyte|immature T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000893		
CL:0000894	biolink:Cell	DN1 thymic pro-T cell	A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative.		hp.json	DN1 thymic pro-T-lymphocyte|DN1 thymic progenitor T cell|preT.DN1.Th|DN1 thymocyte|double negative 1|DN1 thymic pro-T-cell|DN1 thymic pro-T lymphocyte	http://purl.obolibrary.org/obo/CL_0000894		
CL:0000895	biolink:Cell	naive thymus-derived CD4-positive, alpha-beta T cell	An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low.		hp.json	naive CD4+ T cell|T.4Nve.Sp|naive thymus-derived CD4-positive, alpha-beta T-cell|naive thymus-derived CD4-positive, alpha-beta T lymphocyte|naive thymus-derived CD4-positive, alpha-beta T-lymphocyte|Th0	http://purl.obolibrary.org/obo/CL_0000895		
CL:0000896	biolink:Cell	activated CD4-positive, alpha-beta T cell	A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive.		hp.json	activated CD4-positive, alpha-beta T-cell|activated CD4-positive, alpha-beta T lymphocyte|activated CD4-positive, alpha-beta T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000896		
UBERON:0007590	biolink:AnatomicalEntity	cuboidal oviduct epithelium	A cuboidal epithelium that is part of a oviduct.	MA:0001720	hp.json		http://purl.obolibrary.org/obo/UBERON_0007590		human_reference_atlas
CL:0000864	biolink:Cell	tissue-resident macrophage	A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.	FMA:84644|FMA:84642	hp.json	resting histiocyte|fixed macrophage	http://purl.obolibrary.org/obo/CL_0000864		
UBERON:0007592	biolink:AnatomicalEntity	ciliated columnar epithelium	Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA].	FMA:64798	hp.json		http://purl.obolibrary.org/obo/UBERON_0007592		
CHEBI:17568	biolink:ChemicalSubstance	uracil	A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription.	MetaCyc:URACIL|PMID:22447672|KEGG:C00106|PMID:22567906|PMID:18815805|PMID:22685418|CAS:66-22-8|PMID:22483865|CAS:66-22-8|PMID:18533995|KEGG:D00027|PMID:22299724|PMID:12855717|PMID:11279060|PMID:22237209|Beilstein:606623|PDBeChem:URA|DrugBank:DB03419|PMID:15274295|Reaxys:606623|PMID:17439666|PMID:22020693|PMID:3654008|PMID:22356544|PMID:22171528|PMID:22074393|HMDB:HMDB0000300|Gmelin:2896|PMID:16834123|KNApSAcK:C00001513|PMID:22120518|PMID:19175333|CAS:66-22-8|Wikipedia:Uracil	hp.json	Uracil|Ura|2,4-Pyrimidinedione|2,4-Dioxopyrimidine|URACIL|Urazil|pyrimidine-2,4(1H,3H)-dione|uracil|U|2,4(1H,3H)-pyrimidinedione	http://purl.obolibrary.org/obo/CHEBI_17568		3_STAR
CL:0000878	biolink:Cell	central nervous system macrophage	A tissue-resident macrophage found in the central nervous system.		hp.json	CNS macrophage	http://purl.obolibrary.org/obo/CL_0000878		
CHEBI:17553	biolink:ChemicalSubstance	O-phosphoethanolamine	The ethanolamine mono-ester of phosphoric acid, and a metabolite of phospholipid metabolism. This phosphomonoester shows strong structural similarity to the inhibitory neurotransmitter GABA, and is decreased in post-mortem Alzheimer's disease brain.	Gmelin:663022|KEGG:C00346|MetaCyc:PHOSPHORYL-ETHANOLAMINE|DrugBank:DB01738|PDBeChem:OPE|Beilstein:1758916|Reaxys:1758916|CAS:1071-23-4|CAS:1071-23-4|PMID:7791524|CAS:1071-23-4|PMID:1112054	hp.json	pEtN|PETN|monoaminoethyl phosphate|mono(2-aminoethyl) phosphate|PEA|2-aminoethyl dihydrogen phosphate|colaminphosphoric acid|ethanolamine acid phosphate|O-Phosphoethanolamine|2-amino-ethanol dihydrogen phosphate|phosphoric acid 2-aminoethyl phenyl ester|O-phosphocolamine|ethanolamine O-phosphate|colamine phosphate|2-amino-ethanol phosphate|Ethanolamine phosphate|PE|EAP|phosphoryl-ethanolamine|OPE|Phosphoethanolamine|ethanolamine O-phosphate|colamine phosphoric acid|O-Phosphorylethanolamine	http://purl.obolibrary.org/obo/CHEBI_17553		3_STAR
UBERON:0007589	biolink:AnatomicalEntity	ciliated columnar oviduct epithelium	A ciliated columnar epithelium that is part of a oviduct.	FMA:62016|MA:0001719	hp.json	epithelium of uterine tube|uterine tube epithelium	http://purl.obolibrary.org/obo/UBERON_0007589		human_reference_atlas
CL:0000842	biolink:Cell	mononuclear cell	A leukocyte with a single non-segmented nucleus in the mature form.	BTO:0000878|FMA:86713|CALOHA:TS-0768	hp.json	peripheral blood mononuclear cell|mononuclear leukocyte	http://purl.obolibrary.org/obo/CL_0000842		
CL:0000845	biolink:Cell	marginal zone B cell of spleen	A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high.		hp.json	MZ B-cell|marginal zone of spleen B cell|MZ B lymphocyte|B cell of marginal zone of spleen|marginal zone B cell|MZ B-lymphocyte|marginal zone B-cell|marginal zone B lymphocyte|marginal zone B-lymphocyte|MZ B cell	http://purl.obolibrary.org/obo/CL_0000845		
UBERON:0020550	biolink:AnatomicalEntity	auricular blood vessel	A blood vessel that supplies or drains an ear.	EMAPA:37386|MA:0001226	hp.json		http://purl.obolibrary.org/obo/UBERON_0020550		
HP:0002908	biolink:PhenotypicFeature	Conjugated hyperbilirubinemia		UMLS:C0268307|SNOMEDCT_US:9326001	hp.json	Direct hyperbilirubinemia	http://purl.obolibrary.org/obo/HP_0002908		
HP:0002909	biolink:PhenotypicFeature	Generalized aminoaciduria	An increased concentration of all types of amino acid in the urine.	UMLS:C1847868	hp.json	Generalized nonspecific aminoaciduria|Generalised aminoaciduria|Generalised nonspecific aminoaciduria	http://purl.obolibrary.org/obo/HP_0002909		
HP:0002902	biolink:PhenotypicFeature	Hyponatremia	An abnormally decreased sodium concentration in the blood.	MSH:D007010|SNOMEDCT_US:89627008|UMLS:C0020625	hp.json	Low blood sodium levels	http://purl.obolibrary.org/obo/HP_0002902		
HP:0002900	biolink:PhenotypicFeature	Hypokalemia	An abnormally decreased potassium concentration in the blood.	SNOMEDCT_US:43339004|UMLS:C0020621|MSH:D007008|SNOMEDCT_US:166690008	hp.json	Low blood potassium levels	http://purl.obolibrary.org/obo/HP_0002900		
HP:0002901	biolink:PhenotypicFeature	Hypocalcemia	An abnormally decreased calcium concentration in the blood.	UMLS:C0020598|MSH:D006996|SNOMEDCT_US:5291005	hp.json	Low blood calcium levels|Hypocalcaemia	http://purl.obolibrary.org/obo/HP_0002901		
HP:0002907	biolink:PhenotypicFeature	Microscopic hematuria	Microscopic hematuria detected by dipstick or microscopic examination of the urine.	UMLS:C0239937|SNOMEDCT_US:197940006	hp.json	Occult hematuria|Small amount of blood in urine|Microhematuria	http://purl.obolibrary.org/obo/HP_0002907		
HP:0002904	biolink:PhenotypicFeature	Hyperbilirubinemia	An increased amount of bilirubin in the blood.	SNOMEDCT_US:26165005|UMLS:C0311468	hp.json	High blood bilirubin levels	http://purl.obolibrary.org/obo/HP_0002904		
HP:0002905	biolink:PhenotypicFeature	Hyperphosphatemia	An abnormally increased phosphate concentration in the blood.	UMLS:C0553706|UMLS:C0085681|MSH:D054559|SNOMEDCT_US:20165001	hp.json	High blood phosphate levels	http://purl.obolibrary.org/obo/HP_0002905		
PR:P02686	biolink:Protein	myelin basic protein (human)	A myelin basic protein that is encoded in the genome of human.	Reactome:R-HSA-9614770|UniProtKB:P02686	hp.json	MBP|hMBP|myelin membrane encephalitogenic protein (human)|myelin A1 protein (human)	http://purl.obolibrary.org/obo/PR_P02686		
CL:0000825	biolink:Cell	pro-NK cell	A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative.		hp.json	NKP|preNK cell|natural killer cell progenitor|pro-natural killer cell|null cell	http://purl.obolibrary.org/obo/CL_0000825		
CL:0000826	biolink:Cell	pro-B cell	A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.	BTO:0003104	hp.json	pro-B-lymphocyte|pre-pro B cell|progenitor B-lymphocyte|pre-B cell (Philadelphia nomenclature)|progenitor B cell|pro-B-cell|pro-B lymphocyte|progenitor B-cell|progenitor B lymphocyte	http://purl.obolibrary.org/obo/CL_0000826		
CL:0000827	biolink:Cell	pro-T cell	A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.		hp.json	DN1 thymocyte|pro-T lymphocyte|DN1 cell|TN1 cell|progenitor T cell	http://purl.obolibrary.org/obo/CL_0000827		
CHEBI:17522	biolink:ChemicalSubstance	alditol	A carbohydrate that is an acyclic polyol having the general formula HOCH2[CH(OH)]nCH2OH (formally derivable from an aldose by reduction of the carbonyl group).	Wikipedia:Glycerin|KEGG:C00717	hp.json	alditols|Glycitol|Alditol|Sugar alcohol|alditol	http://purl.obolibrary.org/obo/CHEBI_17522		3_STAR
CL:0000839	biolink:Cell	myeloid lineage restricted progenitor cell	A progenitor cell restricted to the myeloid lineage.	BTO:0004730|FMA:70339|CALOHA:TS-2099	hp.json	myeloid progenitor cell	http://purl.obolibrary.org/obo/CL_0000839		
CL:0000831	biolink:Cell	mast cell progenitor	A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative.		hp.json	colony forming unit mast cell|CFU-MC|CFU-Mast|MCP	http://purl.obolibrary.org/obo/CL_0000831		
CL:0000834	biolink:Cell	neutrophil progenitor cell	A progenitor cell of the neutrophil lineage.		hp.json	neutrophil stem cell	http://purl.obolibrary.org/obo/CL_0000834		
CL:0000835	biolink:Cell	myeloblast	The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow.	BTO:0000187|FMA:83524	hp.json		http://purl.obolibrary.org/obo/CL_0000835		
CL:0000837	biolink:Cell	hematopoietic multipotent progenitor cell	A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.	CALOHA:TS-0448|BTO:0000725	hp.json	hemopoietic progenitor cell|MPP	http://purl.obolibrary.org/obo/CL_0000837		
CL:0000838	biolink:Cell	lymphoid lineage restricted progenitor cell	A progenitor cell restricted to the lymphoid lineage.	BTO:0004731|FMA:70338|CALOHA:TS-2025	hp.json	lymphoid progenitor cell	http://purl.obolibrary.org/obo/CL_0000838		
GO:0005737	biolink:CellularComponent	cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	Wikipedia:Cytoplasm	hp.json		http://purl.obolibrary.org/obo/GO_0005737		goslim_chembl|goslim_metagenomics|goslim_yeast|goslim_candida|prokaryote_subset|goslim_pir|goslim_plant
GO:0005730	biolink:CellularComponent	nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.	NIF_Subcellular:sao1820400233|Wikipedia:Nucleolus	hp.json		http://purl.obolibrary.org/obo/GO_0005730		goslim_generic|goslim_candida|goslim_yeast|goslim_plant|goslim_pir|goslim_drosophila|goslim_aspergillus|goslim_chembl
CHEBI:136849	biolink:ChemicalSubstance	3-oxo-Delta(4)-steroid group	An organic group derived from any 3-oxo-Delta(4)-steroid.		hp.json	a 3-oxo-Delta4-steroid group	http://purl.obolibrary.org/obo/CHEBI_136849		3_STAR
UBERON:0007652	biolink:AnatomicalEntity	esophageal sphincter	A sphincter that is part of an esophagus.		hp.json		http://purl.obolibrary.org/obo/UBERON_0007652		
UBERON:0007651	biolink:AnatomicalEntity	anatomical junction	An anatomical structure that connects two structures.	FMA:5898|SCTID:91833003	hp.json	junction|anatomical junction	http://purl.obolibrary.org/obo/UBERON_0007651		upper_level
OBO:hp#display_label	biolink:NamedThing	display label			hp.json		http://purl.obolibrary.org/obo/hp#display_label		
GO:0005739	biolink:CellularComponent	mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.	Wikipedia:Mitochondrion|NIF_Subcellular:sao1860313010	hp.json	mitochondria	http://purl.obolibrary.org/obo/GO_0005739		goslim_flybase_ribbon|goslim_drosophila|goslim_chembl|goslim_mouse|goslim_generic|goslim_agr|goslim_candida|goslim_yeast|goslim_pir|goslim_plant
HP:0012297	biolink:PhenotypicFeature	Slender proximal phalanx of finger	Reduced diameter of the proximal phalanx of finger.	UMLS:C4022961	hp.json	Slender innermost bone of finger	http://purl.obolibrary.org/obo/HP_0012297		
HP:0012298	biolink:PhenotypicFeature	Long middle phalanx of finger	Increased length of the middle phalanx of finger.	UMLS:C4022960	hp.json	Long middle bone of finger	http://purl.obolibrary.org/obo/HP_0012298		
HP:0012299	biolink:PhenotypicFeature	Long distal phalanx of finger	Increased length of the distal phalanx of finger.	UMLS:C4021865	hp.json	Long outermost bone of finger	http://purl.obolibrary.org/obo/HP_0012299		
GO:0005746	biolink:CellularComponent	mitochondrial respirasome	The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.		hp.json	mitochondrial electron transport chain|mitochondrial respiratory supercomplex|mitochondrial respiratory chain supercomplex|mitochondrial respiratory chain	http://purl.obolibrary.org/obo/GO_0005746		
GO:0005743	biolink:CellularComponent	mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.	NIF_Subcellular:sao1371347282|Wikipedia:Inner_mitochondrial_membrane	hp.json	inner mitochondrion membrane|mitochondrion inner membrane|inner mitochondrial membrane	http://purl.obolibrary.org/obo/GO_0005743		
NCBITaxon:7898	biolink:OrganismalEntity	Actinopterygii		GC_ID:1	hp.json	ray-finned fishes|bony fishes|fish|Actinopterygi|Osteichthyes|fishes	http://purl.obolibrary.org/obo/NCBITaxon_7898		
HP:0012290	biolink:PhenotypicFeature	obsolete Mouth neoplasm			hp.json		http://purl.obolibrary.org/obo/HP_0012290		
GO:0005740	biolink:CellularComponent	mitochondrial envelope	The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.		hp.json		http://purl.obolibrary.org/obo/GO_0005740		goslim_candida|goslim_yeast
HP:0012291	biolink:PhenotypicFeature	obsolete Tracheal neoplasm			hp.json		http://purl.obolibrary.org/obo/HP_0012291		
CHEBI:136859	biolink:ChemicalSubstance	pro-agent	A compound that, on administration, undergoes conversion by biochemical (enzymatic), chemical (possibly following an enzymatic step), or physical (e.g. photochemical) activation processes before becoming the active agent for which it is a pro-agent.	PMID:26449612	hp.json	pro-agents|proagents|proagent	http://purl.obolibrary.org/obo/CHEBI_136859		3_STAR
HP:0012292	biolink:PhenotypicFeature	Fusion of gums	A congenital defect with an abnormal joining of the gums of the upper and lower jaw.	UMLS:C4022966	hp.json	Gingival synechia|Synechia of the gums|Fusion of gums|Partial fusion of the gums|Fusion of the gingiva|Upper and lower gums fused together	http://purl.obolibrary.org/obo/HP_0012292		
HP:0012293	biolink:PhenotypicFeature	Abnormal genital pigmentation	An abnormal pigmentation pattern of the external genitalia.	UMLS:C4022965	hp.json		http://purl.obolibrary.org/obo/HP_0012293		
HP:0012294	biolink:PhenotypicFeature	Abnormal occipital bone morphology	Abnormality of the occipital bone of the skull.	UMLS:C4022964	hp.json	Abnormality of the occipital bone	http://purl.obolibrary.org/obo/HP_0012294		
HP:0012295	biolink:PhenotypicFeature	Slender middle phalanx of finger	Reduced diameter of the middle phalanx of finger.	UMLS:C4022963	hp.json	Slender middle bone of finger	http://purl.obolibrary.org/obo/HP_0012295		
HP:0012296	biolink:PhenotypicFeature	Slender distal phalanx of finger	Reduced diameter of the distal phalanx of finger.	UMLS:C4022962	hp.json	Slender outermost bone of finger	http://purl.obolibrary.org/obo/HP_0012296		
UBERON:0007641	biolink:AnatomicalEntity	trigeminal nuclear complex	The sensory trigeminal nerve nuclei are the largest of the cranial nerve nuclei, and extend through the whole of the midbrain, pons and medulla. There is also a distinct trigeminal motor nucleus that is medial to the chief sensory nucleus[WP].	FMA:71248|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2021|CALOHA:TS-2077|BM:V|BIRNLEX:4096|DHBA:266441713|Wikipedia:Trigeminal_nerve_nuclei|HBA:9203|UMLS:C0040999	hp.json	nuclei trigemini|trigeminal nuclei|nuclei trigemini	http://purl.obolibrary.org/obo/UBERON_0007641		
CHEBI:78433	biolink:ChemicalSubstance	refrigerant	A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure.	Wikipedia:Refrigerant	hp.json	refrigerants	http://purl.obolibrary.org/obo/CHEBI_78433		3_STAR
UBERON:0007647	biolink:AnatomicalEntity	ectomeninx	The outermost layer of the mesenchymal capsule that surrounds the developing brain, of mixed paraxial mesoderm and neural crest origin. The ectomeninx forms the dura mater (both inner layer and outer chondrogenic layer).	EHDAA2:0004317	hp.json	future dura mater	http://purl.obolibrary.org/obo/UBERON_0007647		
UBERON:0007646	biolink:AnatomicalEntity	endomeninx	The innermost layer of the mesenchymal capsule that surrounds the developing brain, primarily of neural crest origin. The endomeninx forms the leptomeninx.		hp.json	future leptomeninges|future leptomeninx	http://purl.obolibrary.org/obo/UBERON_0007646		
UBERON:0007645	biolink:AnatomicalEntity	future meninx	A developing mesenchymal capsule that covers the developing brain and spinal cord and is the precursor of the meningeal cluster. In mammals this gives rise to the arachnoid mater, pia mater and dura mater. In cyclostomes and fishes, the future meninx gives rise to a single meningeal layer, the primitive meninx.	EHDAA2:0004453	hp.json	primordial meninx|primary meninx|meninx primitiva|primitive meninx	http://purl.obolibrary.org/obo/UBERON_0007645		pheno_slim
UBERON:0007644	biolink:AnatomicalEntity	thoracic lymph node	A lymph node that is part of a thorax. Includes lymph nodes of the lungs and mediastinal lymph nodes.	UMLS:C0229745|FMA:12772|NCIT:C33769	hp.json	deep thoracic lymph node|lymph node of thorax	http://purl.obolibrary.org/obo/UBERON_0007644		
HP:0012286	biolink:PhenotypicFeature	Abnormal hypothalamus morphology	Any structural anomaly of the hypothalamus.	UMLS:C4021095	hp.json	Abnormality of hypothalamus morphology|Abnormal shape of hypothalamus|Abnormality of the hypothalamus	http://purl.obolibrary.org/obo/HP_0012286		
HP:0012287	biolink:PhenotypicFeature	Hypothalamic luteinizing hormone-releasing hormone deficiency	Decreased secretion of luteinizing hormone-releasing hormone by the hypothalamus.	UMLS:C4022967	hp.json		http://purl.obolibrary.org/obo/HP_0012287		
HP:0012288	biolink:PhenotypicFeature	Neoplasm of head and neck	A tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx.	SNOMEDCT_US:255056009|SNOMEDCT_US:255055008|UMLS:C0018671|MSH:D006258|UMLS:C0278996	hp.json	Head and neck cancer|Head and neck tumor|Head and neck tumour	http://purl.obolibrary.org/obo/HP_0012288		
HP:0012289	biolink:PhenotypicFeature	Facial neoplasm	A tumor (abnormal growth of tissue) of the face.	NCIT:C3262|UMLS:C0015461|SNOMEDCT_US:126632002|MSH:D005153	hp.json	Face tumor|Face tumour	http://purl.obolibrary.org/obo/HP_0012289		
HP:0012280	biolink:PhenotypicFeature	Hepatic amyloidosis	A form of amyloidosis that affects the liver.	SNOMEDCT_US:9551004|UMLS:C0267839	hp.json		http://purl.obolibrary.org/obo/HP_0012280		
HP:0012281	biolink:PhenotypicFeature	Chylous ascites	Extravasation of chyle into the peritoneal cavity.	MSH:D002915|UMLS:C0008732|SNOMEDCT_US:52985009	hp.json	Chyloperitoneum	http://purl.obolibrary.org/obo/HP_0012281		
HP:0012282	biolink:PhenotypicFeature	Morbilliform rash	An exanthema consisting of widespread pink-to-red macules (flat spots of 2-10 mm in diameter) or papules (red bumps) that blanch with pressure. The macules and papules may cluster and merge to form sheets over several days.	SNOMEDCT_US:50495000|SNOMEDCT_US:247470007|UMLS:C0234918	hp.json		http://purl.obolibrary.org/obo/HP_0012282		
HP:0012283	biolink:PhenotypicFeature	Small distal femoral epiphysis	Reduced size of the Distal epiphysis of femur.	UMLS:C4022970	hp.json	Small end part of outermost thighbone	http://purl.obolibrary.org/obo/HP_0012283		
HP:0012284	biolink:PhenotypicFeature	Small proximal tibial epiphyses	Reduced size of the proximal epiphysis of the tibia.	UMLS:C4022969	hp.json	Small end part of innermost shinbone|Small end part of innermost shankbone	http://purl.obolibrary.org/obo/HP_0012284		
HP:0012285	biolink:PhenotypicFeature	Abnormal hypothalamus physiology	An abnormal functionality of the hypothalamus.	UMLS:C4022968	hp.json		http://purl.obolibrary.org/obo/HP_0012285		
HP:0000297	biolink:PhenotypicFeature	Facial hypotonia	Reduced muscle tone of a muscle that is innervated by the facial nerve (the seventh cranial nerve).	UMLS:C1845251|UMLS:C4280646	hp.json	Hypotonic facies|Low facial muscle tone|Atony of facial musculature|Decreased facial muscle tone|Reduced facial muscle tone	http://purl.obolibrary.org/obo/HP_0000297		
GO:0042703	biolink:BiologicalProcess	menstruation	The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.	Wikipedia:Menstruation	hp.json		http://purl.obolibrary.org/obo/GO_0042703		gocheck_do_not_annotate
GO:0042702	biolink:BiologicalProcess	uterine wall growth	The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels.		hp.json		http://purl.obolibrary.org/obo/GO_0042702		
HP:0000298	biolink:PhenotypicFeature	Mask-like facies	A lack of facial expression often with staring eyes and a slightly open mouth.	UMLS:C0424448|SNOMEDCT_US:103606006	hp.json	Expressionless face|Lack of facial expression|Masklike facies|Amimia|Mask-like facial appearance	http://purl.obolibrary.org/obo/HP_0000298		
CHEBI:78444	biolink:ChemicalSubstance	EC 3.1.1.1 (carboxylesterase) inhibitor	Any EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that inhibits the action of carboxylesterase (EC 3.1.1.1 ).		hp.json	serine esterase inhibitor|triacetin esterase inhibitors|ali-esterase inhibitors|serine esterase inhibitors|ali-esterase inhibitor|triacetin esterase inhibitor|carboxylic-ester hydrolase inhibitors|esterase A inhibitors|esterase B inhibitors|vitamin A esterase inhibitor|Beta-esterase inhibitor|carboxylic esterase inhibitor|butyryl esterase inhibitors|monobutyrase inhibitor|esterase D inhibitors|procaine esterase inhibitor|nonspecific carboxylesterase inhibitor|carboxyl ester hydrolase inhibitors|carboxylesterase inhibitor|cocaine esterase inhibitor|Alpha-carboxylesterase inhibitor|methylbutyrate esterase inhibitor|butyrate esterase inhibitor|carboxylate esterase inhibitor|propionyl esterase inhibitor|methylbutyrase inhibitor|carboxylic acid esterase inhibitors|carboxylate esterase inhibitors|carboxylic acid esterase inhibitor|propionyl esterase inhibitors|methylbutyrase inhibitors|butyrate esterase inhibitors|methylbutyrate esterase inhibitors|Alpha-carboxylesterase inhibitors|cocaine esterase inhibitors|carboxylesterase inhibitors|carboxyl ester hydrolase inhibitor|esterase D inhibitor|nonspecific carboxylesterase inhibitors|procaine esterase inhibitors|butyryl esterase inhibitor|carboxylic esterase inhibitors|monobutyrase inhibitors|esterase B inhibitor|vitamin A esterase inhibitors|Beta-esterase inhibitors|EC 3.1.1.1 (carboxylesterase) inhibitors|carboxylic-ester hydrolase inhibitor|esterase A inhibitor	http://purl.obolibrary.org/obo/CHEBI_78444		3_STAR
HP:0000291	biolink:PhenotypicFeature	Abnormality of facial adipose tissue		UMLS:C4025866	hp.json	Deformity of facial adipose tissue|Malformation of facial adipose tissue|Abnormality of facial fat	http://purl.obolibrary.org/obo/HP_0000291		
HP:0000290	biolink:PhenotypicFeature	Abnormality of the forehead	An anomaly of the forehead.	UMLS:C4025867	hp.json	Abnormality of the forehead|Abnormality of the frontal region of the face|Deformity of the forehead|Malformation of the forehead|Anomaly of the forehead	http://purl.obolibrary.org/obo/HP_0000290		hposlim_core
HP:0000293	biolink:PhenotypicFeature	Full cheeks	Increased prominence or roundness of soft tissues between zygomata and mandible.	UMLS:C2748653|UMLS:C1866231|UMLS:C3806443|UMLS:C4280648|UMLS:C4280647	hp.json	Full cheeks|Big cheeks|Hyperplasia of cheeks|Increased size of cheeks|Puffy cheeks|Apple cheeks|Large cheeks|Hypertrophy of cheeks|Chubby cheeks	http://purl.obolibrary.org/obo/HP_0000293		hposlim_core
UBERON:0007635	biolink:AnatomicalEntity	nucleus of medulla oblongata	A neural nucleus that is part of a medulla oblongata.	FMA:258772|SCTID:304943004	hp.json		http://purl.obolibrary.org/obo/UBERON_0007635		
HP:0000292	biolink:PhenotypicFeature	Loss of facial adipose tissue	Loss of normal subcutaneous fat tissue in the face.	UMLS:C1837767	hp.json	Decreased amount of facial adipose tissue|Loss of facial subcutaneous adipose tissue|Decreased volume of facial adipose tissue|Loss of subcutaneous adipose tissue from face|Loss of facial fat|Decreased amount of facial fat	http://purl.obolibrary.org/obo/HP_0000292		
HP:0000295	biolink:PhenotypicFeature	Doll-like facies	A characteristic facial appearance with a round facial form, full cheeks, a short nose, and a relatively small chin.	UMLS:C1856361	hp.json	Doll-like facial appearance	http://purl.obolibrary.org/obo/HP_0000295		
HP:0000294	biolink:PhenotypicFeature	Low anterior hairline	Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella.	UMLS:C1842366	hp.json	Low frontal hairline|Low-set frontal hairline	http://purl.obolibrary.org/obo/HP_0000294		hposlim_core
HP:0012275	biolink:PhenotypicFeature	Autosomal dominant inheritance with maternal imprinting	A type of autosomal dominant inheritance involving a gene that is imprinted with maternal silencing.	UMLS:C4022975	hp.json		http://purl.obolibrary.org/obo/HP_0012275		
HP:0012276	biolink:PhenotypicFeature	Digital flexor tenosynovitis	Inflammation of the flexor digitorum tendon, often associated with the Kanavel signs: (i) finger held in slight flexion, (ii) fusiform swelling, (iii) tenderness along the flexor tendon sheath, and (iv) pain with passive extension of the digit.	UMLS:C4022974	hp.json	Trigger finger	http://purl.obolibrary.org/obo/HP_0012276		
HP:0012277	biolink:PhenotypicFeature	Hypoglycinemia	An abnormally reduced concentration of glycine in the blood.	UMLS:C4022973	hp.json	Low blood glycine levels	http://purl.obolibrary.org/obo/HP_0012277		
HP:0012278	biolink:PhenotypicFeature	Abnormal circulating serine concentration	Any deviation from the normal concentration of serine in the blood circulation.	UMLS:C4022972	hp.json		http://purl.obolibrary.org/obo/HP_0012278		
HP:0012279	biolink:PhenotypicFeature	Hyposerinemia	Reduced concentration of serine in the blood.	UMLS:C4022971	hp.json	Low blood serine levels	http://purl.obolibrary.org/obo/HP_0012279		
UBERON:0007619	biolink:AnatomicalEntity	limiting membrane of retina		MA:0001318	hp.json	retina lamina	http://purl.obolibrary.org/obo/UBERON_0007619		grouping_class
UBERON:0007618	biolink:AnatomicalEntity	synovial cavity of hip joint	A synovial cavity of joint that is part of a hip joint.	FMA:9701|EMAPA:19021	hp.json		http://purl.obolibrary.org/obo/UBERON_0007618		
NCBITaxon:40151	biolink:OrganismalEntity	Monodon monoceros			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_40151		
HP:0012270	biolink:PhenotypicFeature	Decreased muscle glycogen content	A decreased amount of glycogen in muscle tissue.	UMLS:C4022979	hp.json		http://purl.obolibrary.org/obo/HP_0012270		
HP:0012271	biolink:PhenotypicFeature	Episodic upper airway obstruction	Intermittent episodes of increased resistance to the passage of air in the upper airway.	UMLS:C4022978	hp.json		http://purl.obolibrary.org/obo/HP_0012271		
HP:0012272	biolink:PhenotypicFeature	J wave	The J wave is a positive convex deflection that occurs at the junction of the QRS complex and ST segment, the J-point.	UMLS:C4018858	hp.json	EKG J waves|Osborne waves	http://purl.obolibrary.org/obo/HP_0012272		
HP:0012273	biolink:PhenotypicFeature	Increased carotid artery intimal medial thickness	An increase in the combined thickness of the intima and media of the carotid artery.	UMLS:C4022977	hp.json		http://purl.obolibrary.org/obo/HP_0012273		
HP:0012274	biolink:PhenotypicFeature	Autosomal dominant inheritance with paternal imprinting	A type of autosomal dominant inheritance involving a gene that is imprinted with paternal silencing.	UMLS:C4022976	hp.json		http://purl.obolibrary.org/obo/HP_0012274		
GO:0042713	biolink:BiologicalProcess	sperm ejaculation	The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract.		hp.json		http://purl.obolibrary.org/obo/GO_0042713		
NCBITaxon:40150	biolink:OrganismalEntity	Monodon			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_40150		
UBERON:0007625	biolink:AnatomicalEntity	pigment epithelium of eye	Epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules.	MESH:D010857|GAID:907	hp.json	eye pigment epithelium	http://purl.obolibrary.org/obo/UBERON_0007625		pheno_slim
UBERON:0005032	biolink:AnatomicalEntity	mucosa of lower lip	A mucosa that is part of a lower lip [Automatically generated definition].	FMA:59833|SCTID:362089001|NCIT:C12225|UMLS:C0226939	hp.json	lower lip mucous membrane|mucosa of organ of lower lip|lower lip mucosa|lower lip organ mucosa|lower lip mucosa of organ|mucous membrane of lower lip|organ mucosa of lower lip|lower labial mucosa	http://purl.obolibrary.org/obo/UBERON_0005032		
UBERON:0005033	biolink:AnatomicalEntity	mucosa of gallbladder	A mucosa that is part of a gallbladder [Automatically generated definition].	FMA:14662	hp.json	gall bladder mucosa|gall bladder mucosa of organ|gall bladder organ mucosa|mucous membrane of gallbladder|organ mucosa of gallbladder|gallbladder mucosa of organ|tunica mucosa (vesica biliaris)|gall bladder mucous membrane|tunica mucosa vesicae biliaris|mucosa of organ of gall bladder|gallbladder mucous membrane|mucosa of organ of gallbladder|mucosa of gall bladder|gallbladder mucosa|organ mucosa of gall bladder|mucous membrane of gall bladder|gallbladder organ mucosa	http://purl.obolibrary.org/obo/UBERON_0005033		
UBERON:0005030	biolink:AnatomicalEntity	mucosa of paranasal sinus	A mucosa that adjacent_to a paranasal sinus.	FMA:59772	hp.json	paranasal sinus mucosa	http://purl.obolibrary.org/obo/UBERON_0005030		
UBERON:0007692	biolink:AnatomicalEntity	nucleus of thalamus	A nucleus of brain that is part of a thalamus.	BTO:0002452|FMA:256693|MA:0002992|EMAPA:35859	hp.json	thalamic nucleus|nuclear complex of thalamus	http://purl.obolibrary.org/obo/UBERON_0007692		
UBERON:0005031	biolink:AnatomicalEntity	mucosa of upper lip	A mucosa that is part of a upper lip [Automatically generated definition].	FMA:59832|UMLS:C0226933|NCIT:C12224	hp.json	upper lip mucosa|upper lip organ mucosa|organ mucosa of upper lip|upper lip mucosa of organ|mucous membrane of upper lip|upper labial mucosa|upper lip mucous membrane|mucosa of organ of upper lip	http://purl.obolibrary.org/obo/UBERON_0005031		
UBERON:0007691	biolink:AnatomicalEntity	gustatory pore	The minute opening of a taste bud on the surface of the oral mucosa through which the gustatory hairs of the specialised neuroepithelial gustatory cells project.	NCIT:C33738|FMA:63589|SCTID:368724008|UMLS:C0226971	hp.json	taste pore|porus gustatorius|porus gustatorius	http://purl.obolibrary.org/obo/UBERON_0007691		
UBERON:0007690	biolink:AnatomicalEntity	early pharyngeal endoderm	.	FMA:293087|ZFA:0001104|EHDAA:962|EHDAA2:0001457|TAO:0001104|EFO:0003626|EMAPA:32754	hp.json	early pharyngeal arch endoderm|pharyngeal arch endoderm|pharyngeal endoderm|pharyngeal region endoderm	http://purl.obolibrary.org/obo/UBERON_0007690		efo_slim
HGNC:12726	biolink:Gene	VWF (human)	A protein coding gene VWF in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12726		
UBERON:0005039	biolink:AnatomicalEntity	mucosa of bronchiole	A mucosa that is part of a bronchiole [Automatically generated definition].	FMA:62774|FMA:263230	hp.json	bronchiole mucosa of organ|mucosa of lobular bronchiole|organ mucosa of lobular bronchiole|mucous membrane of lobular bronchiole|lobular bronchiole mucosa|lobular bronchiole organ mucosa|bronchiole mucous membrane|mucosa of organ of bronchiole|lobular bronchiole mucosa of organ|bronchiole mucosa|bronchiole organ mucosa|organ mucosa of bronchiole|lobular bronchiole mucous membrane|mucous membrane of bronchiole|mucosa of organ of lobular bronchiole	http://purl.obolibrary.org/obo/UBERON_0005039		
UBERON:0007699	biolink:AnatomicalEntity	tract of spinal cord	An axon tract that is part of a spinal cord.	FMA:75683|UMLS:C1519456|NCIT:C12995	hp.json	spinal cord tract	http://purl.obolibrary.org/obo/UBERON_0007699		
GO:0042730	biolink:BiologicalProcess	fibrinolysis	A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.	Wikipedia:Fibrinolysis	hp.json		http://purl.obolibrary.org/obo/GO_0042730		
UBERON:0005024	biolink:AnatomicalEntity	mucosa of soft palate	A mucosa that is part of a soft palate [Automatically generated definition].	FMA:59784	hp.json	soft palate mucosa|soft palate organ mucosa|soft palate mucosa of organ|mucous membrane of soft palate|organ mucosa of soft palate|soft palate mucous membrane|mucosa of organ of soft palate	http://purl.obolibrary.org/obo/UBERON_0005024		
UBERON:0005021	biolink:AnatomicalEntity	mucosa of sphenoidal sinus	A mucosa that is part of a sphenoidal sinus [Automatically generated definition].	FMA:59775	hp.json	mucosa of sphenoid sinus|mucous membrane of sphenoid sinus|mucosa of organ of sphenoidal sinus|organ mucosa of sphenoid sinus|sphenoid sinus mucosa|sphenoid sinus organ mucosa|sphenoid sinus mucosa of organ|organ mucosa of sphenoidal sinus|mucous membrane of sphenoidal sinus|sphenoid sinus mucous membrane|sphenoidal sinus mucosa of organ|sphenoidal sinus mucosa|mucosa of organ of sphenoid sinus|sphenoidal sinus organ mucosa|sphenoidal sinus mucous membrane	http://purl.obolibrary.org/obo/UBERON_0005021		
UBERON:0007684	biolink:AnatomicalEntity	uriniferous tubule	Functional unit of the kidney that forms urine, consisting of two parts, the nephron and the collecting tubule.	FMA:17691	hp.json		http://purl.obolibrary.org/obo/UBERON_0007684		
UBERON:0005022	biolink:AnatomicalEntity	mucosa of nasopharynx	A mucosa that is part of a nasopharynx [Automatically generated definition].	FMA:54971	hp.json	nasal part of pharynx organ mucosa|nasopharynx mucosa|rhinopharynx mucous membrane|nasopharynx organ mucosa|mucosa of organ of rhinopharynx|mucosa of rhinopharynx|mucous membrane of nasopharynx|nasopharynx mucosa of organ|organ mucosa of nasopharynx|organ mucosa of rhinopharynx|mucous membrane of rhinopharynx|nasal part of pharynx mucosa of organ|mucous membrane of nasal part of pharynx|organ mucosa of nasal part of pharynx|mucosa of nasal part of pharynx|mucosa of organ of nasopharynx|nasopharynx mucous membrane|rhinopharynx mucosa|rhinopharynx mucosa of organ|rhinopharynx organ mucosa|nasal part of pharynx mucous membrane|mucosa of organ of nasal part of pharynx|nasal part of pharynx mucosa	http://purl.obolibrary.org/obo/UBERON_0005022		
UBERON:0005020	biolink:AnatomicalEntity	mucosa of tongue	A mucosa that is part of a tongue [Automatically generated definition].	EFO:0002553|FMA:54807|SCTID:362092002	hp.json	tongue mucous membrane|mucosa of organ of tongue|tunica mucosa linguae|organ mucosa of tongue|mucous membrane of tongue|tongue mucosa|tongue organ mucosa|tongue mucosa of organ|lingual mucosa	http://purl.obolibrary.org/obo/UBERON_0005020		efo_slim
CHEBI:17453	biolink:ChemicalSubstance	methylmalonate(2-)	A C4-dicarboxylate resulting from the removal of a proton from both carboxylic acid groups of methylmalonic acid.	MetaCyc:CPD-546|Gmelin:142212|KEGG:C02170|Beilstein:3904597|Reaxys:3904597	hp.json	methylmalonate|methylmalonate dianion|methylpropanedioate	http://purl.obolibrary.org/obo/CHEBI_17453		3_STAR
UBERON:0005027	biolink:AnatomicalEntity	mucosa of frontal sinus	A mucosa that is part of a frontal sinus [Automatically generated definition].	FMA:59774	hp.json	frontal sinus mucosa|frontal sinus organ mucosa|organ mucosa of frontal sinus|mucous membrane of frontal sinus|frontal sinus mucosa of organ|frontal sinus mucous membrane|mucosa of organ of frontal sinus	http://purl.obolibrary.org/obo/UBERON_0005027		
UBERON:0005028	biolink:AnatomicalEntity	mucosa of maxillary sinus	A mucosa that is part of a maxillary sinus [Automatically generated definition].	FMA:59773	hp.json	mucosa of organ of maxillary sinus|maxillary sinus mucous membrane|maxillary sinus mucosa|antrum of highmore mucosa of organ|maxillary sinus organ mucosa|antrum of highmore mucous membrane|mucosa of organ of antrum of highmore|antrum of highmore mucosa|organ mucosa of maxillary sinus|maxillary sinus mucosa of organ|mucous membrane of maxillary sinus|antrum of highmore organ mucosa|mucosa of antrum of highmore|organ mucosa of antrum of highmore|mucous membrane of antrum of highmore	http://purl.obolibrary.org/obo/UBERON_0005028		
UBERON:0007689	biolink:AnatomicalEntity	thyroid diverticulum	Endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor[MP]. The thyroid diverticulum is the embryological structure from which thyroid follicular cells derive. It grows from the floor of the pharnyx[WP].		hp.json	diverticulum thyroideum|saccus thyroideus	http://purl.obolibrary.org/obo/UBERON_0007689		
UBERON:0007688	biolink:AnatomicalEntity	anlage	Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue.	Wikipedia:Anlage_(biology)|FBbt:00005426|EFO:0001649|EHDAA2:0003170|AEO:0000170	hp.json	organ field|developmental field|future organ|field	http://purl.obolibrary.org/obo/UBERON_0007688		efo_slim
UBERON:0005025	biolink:AnatomicalEntity	mucosa of uvula	A mucosa that is part of a uvula [Automatically generated definition].	FMA:60030	hp.json	uvula mucosa	http://purl.obolibrary.org/obo/UBERON_0005025		
UBERON:0005026	biolink:AnatomicalEntity	mucosa of middle ear	A mucosa that is part of a middle ear [Automatically generated definition].	CALOHA:TS-0631|FMA:59663	hp.json	mucosa of organ of middle ear|middle ear mucosa|middle ear organ mucosa|mucous membrane of middle ear|organ mucosa of middle ear|tunica mucosa cavitatis tympanicae|middle ear mucosa of organ|mucosa of tympanic cavity|middle ear mucous membrane	http://purl.obolibrary.org/obo/UBERON_0005026		
UBERON:0007687	biolink:AnatomicalEntity	kidney field	Region of the embryo into the area in which the kidney rudiment will develop.		hp.json	kidney anlage	http://purl.obolibrary.org/obo/UBERON_0007687		
UBERON:0005012	biolink:AnatomicalEntity	mucosa of left uterine tube	A mucosa that is part of a left uterine tube [Automatically generated definition].	FMA:18453	hp.json	left uterine tube mucous membrane|mucosa of organ of left oviduct|mucosa of organ of left uterine tube|left fallopian tube mucosa of organ|mucous membrane of left fallopian tube|left uterine tube mucosa|organ mucosa of left fallopian tube|mucosa of left fallopian tube|left uterine tube organ mucosa|left oviduct mucosa|mucosa of left oviduct|left oviduct organ mucosa|mucous membrane of left oviduct|organ mucosa of left oviduct|left fallopian tube mucous membrane|mucosa of organ of left fallopian tube|left oviduct mucosa of organ|left fallopian tube mucosa|left uterine tube mucosa of organ|organ mucosa of left uterine tube|mucous membrane of left uterine tube|left fallopian tube organ mucosa|left oviduct mucous membrane	http://purl.obolibrary.org/obo/UBERON_0005012		
GO:0042747	biolink:BiologicalProcess	circadian sleep/wake cycle, REM sleep	A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity.		hp.json		http://purl.obolibrary.org/obo/GO_0042747		
UBERON:0005013	biolink:AnatomicalEntity	mucosa of male urethra	A mucosa that is part of a male urethra [Automatically generated definition].	FMA:239937	hp.json	male urethra mucosa|male urethra organ mucosa|male urethra mucous membrane|mucosa of organ of male urethra|mucous membrane of male urethra|organ mucosa of male urethra|male urethra mucosa of organ	http://purl.obolibrary.org/obo/UBERON_0005013		
UBERON:0005010	biolink:AnatomicalEntity	mucosa of neck of urinary bladder	A mucosa that is part of a neck of urinary bladder [Automatically generated definition].	FMA:17846	hp.json	organ mucosa of neck of urinary bladder|mucous membrane of neck of urinary bladder|neck of urinary bladder mucosa of organ|vesical neck mucous membrane|bladder neck mucosa|urinary bladder neck mucous membrane|neck of bladder mucosa|bladder neck organ mucosa|mucosa of bladder neck|mucosa of organ of vesical neck|organ mucosa of bladder neck|neck of bladder organ mucosa|mucous membrane of bladder neck|mucosa of organ of urinary bladder neck|mucosa of organ of neck of urinary bladder|neck of urinary bladder mucous membrane|organ mucosa of neck of bladder|neck of bladder mucosa of organ|mucous membrane of neck of bladder|mucosa of vesical neck|mucosa of neck of bladder|bladder neck mucosa of organ|organ mucosa of vesical neck|mucous membrane of vesical neck|neck of urinary bladder mucosa|mucosa of urinary bladder neck|mucous membrane of urinary bladder neck|neck of urinary bladder organ mucosa|organ mucosa of urinary bladder neck|neck of bladder mucous membrane|mucosa of organ of neck of bladder|urinary bladder neck mucosa|vesical neck mucosa of organ|vesical neck mucosa|bladder neck mucous membrane|urinary bladder neck mucosa of organ|vesical neck organ mucosa|mucosa of organ of bladder neck	http://purl.obolibrary.org/obo/UBERON_0005010		
GO:0042749	biolink:BiologicalProcess	regulation of circadian sleep/wake cycle	Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.		hp.json		http://purl.obolibrary.org/obo/GO_0042749		
UBERON:0005011	biolink:AnatomicalEntity	mucosa of right uterine tube	A mucosa that is part of a right uterine tube [Automatically generated definition].	FMA:18452	hp.json	mucosa of right fallopian tube|organ mucosa of right fallopian tube|mucous membrane of right fallopian tube|organ mucosa of right oviduct|mucous membrane of right oviduct|right oviduct mucosa of organ|right uterine tube mucous membrane|mucosa of right oviduct|right fallopian tube mucosa of organ|right fallopian tube mucosa|right fallopian tube organ mucosa|mucosa of organ of right uterine tube|right oviduct mucosa|right oviduct organ mucosa|right oviduct mucous membrane|mucosa of organ of right oviduct|right fallopian tube mucous membrane|organ mucosa of right uterine tube|mucous membrane of right uterine tube|right uterine tube mucosa|mucosa of organ of right fallopian tube|right uterine tube organ mucosa|right uterine tube mucosa of organ	http://purl.obolibrary.org/obo/UBERON_0005011		
GO:0042742	biolink:BiologicalProcess	defense response to bacterium	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.		hp.json	defense response to bacterium, incompatible interaction|defence response to bacterium|resistance response to pathogenic bacteria|defense response to bacteria|defence response to bacteria|resistance response to pathogenic bacterium|antibacterial peptide activity	http://purl.obolibrary.org/obo/GO_0042742		
GO:0042745	biolink:BiologicalProcess	circadian sleep/wake cycle	The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.		hp.json		http://purl.obolibrary.org/obo/GO_0042745		
UBERON:0005018	biolink:AnatomicalEntity	mucosa of nasal septum	A mucosa that is part of a nasal septum [Automatically generated definition].	FMA:60113|EMAPA:36028	hp.json	nasal septum mucosa of organ|nasal septum mucous membrane|mucosa of organ of nasal septum|nasal septum mucosa|nasal septum organ mucosa|organ mucosa of nasal septum|mucous membrane of nasal septum	http://purl.obolibrary.org/obo/UBERON_0005018		
UBERON:0005019	biolink:AnatomicalEntity	mucosa of palate	A mucosa that is part of a palate [Automatically generated definition].	FMA:59765	hp.json	palate mucosa of organ|mucous membrane of oral roof|oral roof mucosa of organ|organ mucosa of oral roof|oral roof mucosa|mucosa of organ of roof of mouth|palate mucosa|roof of mouth mucous membrane|oral roof organ mucosa|mucosa of oral roof|palate organ mucosa|palate mucous membrane|roof of mouth mucosa|roof of mouth organ mucosa|oral roof mucous membrane|mucosa of organ of oral roof|mucosa of organ of palate|organ mucosa of palate|mucous membrane of palate|organ mucosa of roof of mouth|roof of mouth mucosa of organ|mucous membrane of roof of mouth|mucosa of roof of mouth	http://purl.obolibrary.org/obo/UBERON_0005019		
CHEBI:17485	biolink:ChemicalSubstance	homocystine	An organic disulfide obtained by oxidative dimerisation of homocysteine.	KEGG:C01817|Reaxys:1728581|HMDB:HMDB0000575|CAS:462-10-2|PMID:11592966|CAS:462-10-2|PMID:11896744	hp.json	4,4'-disulfanediylbis(2-aminobutanoic acid)|4,4'-Dithiobis(2-aminobutyric acid)|Homocystine|4,4'-dithiobis(2-aminobutyric acid)	http://purl.obolibrary.org/obo/CHEBI_17485		3_STAR
UBERON:0005017	biolink:AnatomicalEntity	mucosa of lacrimal sac	A mucosa that is part of a lacrimal sac [Automatically generated definition].	FMA:72061	hp.json	lacrimal sac mucosa|lacrimal sac organ mucosa|lacrimal sac mucous membrane|mucosa of organ of lacrimal sac|mucous membrane of lacrimal sac|organ mucosa of lacrimal sac|lacrimal sac mucosa of organ	http://purl.obolibrary.org/obo/UBERON_0005017		
UBERON:0005014	biolink:AnatomicalEntity	mucosa of female urethra	A mucosa that is part of a female urethra [Automatically generated definition].	FMA:239940	hp.json	female urethra mucosa|female urethra organ mucosa|female urethra mucous membrane|mucosa of organ of female urethra|organ mucosa of female urethra|mucous membrane of female urethra|female urethra mucosa of organ	http://purl.obolibrary.org/obo/UBERON_0005014		
GO:0042752	biolink:BiologicalProcess	regulation of circadian rhythm	Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.		hp.json		http://purl.obolibrary.org/obo/GO_0042752		
UBERON:0005001	biolink:AnatomicalEntity	mucosa of common hepatic duct	A mucosa that is part of a common hepatic duct [Automatically generated definition].	FMA:14691	hp.json	common hepatic duct mucosa|common hepatic duct organ mucosa|hepatic duct mucosa of organ|mucosa of organ of common hepatic duct|common hepatic duct mucous membrane|common hepatic ductal mucosa|hepatic duct mucous membrane|mucosa of organ of hepatic duct|hepatic duct mucosa|hepatic duct organ mucosa|mucous membrane of common hepatic duct|organ mucosa of common hepatic duct|mucosa of hepatic duct|common hepatic duct mucosa of organ|mucous membrane of hepatic duct|organ mucosa of hepatic duct	http://purl.obolibrary.org/obo/UBERON_0005001		
UBERON:0005002	biolink:AnatomicalEntity	mucosa of right hepatic duct	A mucosa that is part of a right hepatic duct [Automatically generated definition].	FMA:14692	hp.json	right hepatic duct mucosa of organ|right hepatic duct mucosa|right hepatic duct organ mucosa|right hepatic duct mucous membrane|right hepatic ductal mucosa|mucosa of organ of right hepatic duct|mucous membrane of right hepatic duct|organ mucosa of right hepatic duct	http://purl.obolibrary.org/obo/UBERON_0005002		
UBERON:0005000	biolink:AnatomicalEntity	mucosa of common bile duct	A mucosa that is part of a common bile duct [Automatically generated definition].	FMA:14688	hp.json	common bile ductal mucosa|ductus choledochus (biliaris) mucosa of organ|organ mucosa of common bile duct|organ mucosa of ductus choledochus (biliaris)|mucous membrane of ductus choledochus (biliaris)|mucous membrane of common bile duct|mucosa of ductus choledochus (biliaris)|common bile duct mucosa|common bile duct organ mucosa|common bile duct mucosa of organ|mucosa of organ of ductus choledochus (biliaris)|ductus choledochus (biliaris) mucous membrane|ductus choledochus (biliaris) mucosa|ductus choledochus (biliaris) organ mucosa|common bile duct mucous membrane|mucosa of organ of common bile duct	http://purl.obolibrary.org/obo/UBERON_0005000		
GO:0042754	biolink:BiologicalProcess	negative regulation of circadian rhythm	Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.		hp.json	downregulation of circadian rhythm|down regulation of circadian rhythm|inhibition of circadian rhythm|down-regulation of circadian rhythm	http://purl.obolibrary.org/obo/GO_0042754		
GO:0042753	biolink:BiologicalProcess	positive regulation of circadian rhythm	Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.		hp.json	up-regulation of circadian rhythm|activation of circadian rhythm|upregulation of circadian rhythm|up regulation of circadian rhythm|stimulation of circadian rhythm	http://purl.obolibrary.org/obo/GO_0042753		
GO:0042756	biolink:BiologicalProcess	drinking behavior	The specific behavior of an organism relating to the intake of liquids, especially water.		hp.json	drinking behaviour	http://purl.obolibrary.org/obo/GO_0042756		
GO:0042755	biolink:BiologicalProcess	eating behavior	The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.		hp.json	eating behaviour	http://purl.obolibrary.org/obo/GO_0042755		
CHEBI:17478	biolink:ChemicalSubstance	aldehyde	A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.	KEGG:C00071	hp.json	RC(=O)H|aldehido|Aldehyd|aldehydes|aldehydes|aldehyde|an aldehyde|aldehyde|RCHO|aldehydum|aldehidos|Aldehyde	http://purl.obolibrary.org/obo/CHEBI_17478		3_STAR
UBERON:0005005	biolink:AnatomicalEntity	mucosa of left ureter	A mucosa that is part of a left ureter [Automatically generated definition].	FMA:17807	hp.json	left ureteral mucosa|mucous membrane of left ureter|left ureter mucosa of organ|organ mucosa of left ureter|left ureter mucous membrane|mucosa of organ of left ureter|left ureter mucosa|left ureter organ mucosa	http://purl.obolibrary.org/obo/UBERON_0005005		human_reference_atlas
UBERON:0005006	biolink:AnatomicalEntity	mucosa of renal pelvis	A mucosa that is part of a renal pelvis [Automatically generated definition].	FMA:17931	hp.json	organ mucosa of renal pelvis|mucous membrane of renal pelvis|pelvis of ureter mucous membrane|mucosa of organ of pelvis of ureter|renal pelvis mucosa of organ|pelvis of ureter mucosa|mucosa of pelvis of ureter|tunica mucosa pelvis renalis|pelvis of ureter organ mucosa|kidney pelvis mucosa|organ mucosa of pelvis of ureter|mucous membrane of pelvis of ureter|kidney pelvis organ mucosa|renal pelvis mucous membrane|mucous membrane of kidney pelvis|organ mucosa of kidney pelvis|kidney pelvis mucosa of organ|mucosa of kidney pelvis|mucosa of organ of renal pelvis|pelvis of ureter mucosa of organ|renal pelvic mucosa|renal pelvis mucosa|mucosa of organ of kidney pelvis|renal pelvis organ mucosa|kidney pelvis mucous membrane	http://purl.obolibrary.org/obo/UBERON_0005006		
UBERON:0005003	biolink:AnatomicalEntity	mucosa of left hepatic duct	A mucosa that is part of a left hepatic duct [Automatically generated definition].	FMA:14693	hp.json	mucosa of organ of left hepatic duct|left hepatic duct mucous membrane|left hepatic duct mucosa|left hepatic duct organ mucosa|organ mucosa of left hepatic duct|left hepatic duct mucosa of organ|mucous membrane of left hepatic duct|left hepatic ductal mucosa	http://purl.obolibrary.org/obo/UBERON_0005003		
UBERON:0005004	biolink:AnatomicalEntity	mucosa of right ureter	A mucosa that is part of a right ureter [Automatically generated definition].	FMA:17806	hp.json	mucosa of organ of right ureter|mucous membrane of right ureter|organ mucosa of right ureter|right ureter mucosa|right ureter organ mucosa|right ureter mucosa of organ|right ureteral mucosa|right ureter mucous membrane	http://purl.obolibrary.org/obo/UBERON_0005004		
HP:0012220	biolink:PhenotypicFeature	Non-caseating epithelioid cell granulomatosis	The presence of multiple epithelioid cell granulomas consist of highly differentiated mononuclear phagocytes (epithelioid cells and giant cells) and lymphocytes, not exhibiting caseation (a form of necrosis in which the tissue changes into a dry, amorphous mass said to resemble cheese).	UMLS:C4022999	hp.json		http://purl.obolibrary.org/obo/HP_0012220		
HP:0012221	biolink:PhenotypicFeature	Pretibial blistering	A type of blistering that affects the skin of the tibial region.	UMLS:C0432321|SNOMEDCT_US:67653003|MSH:C535494	hp.json	Pretibial epidermolysis bullosa	http://purl.obolibrary.org/obo/HP_0012221		
HGNC:12765	biolink:Gene	FOXN1 (human)	A protein coding gene FOXN1 in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12765		
HP:0012222	biolink:PhenotypicFeature	Arachnoid hemangiomatosis	The presence of multiple hemangiomas in the arachnoid.	UMLS:C4022998	hp.json		http://purl.obolibrary.org/obo/HP_0012222		
HP:0012223	biolink:PhenotypicFeature	Splenic rupture	A breach of the capsule of the spleen.	SNOMEDCT_US:234506007|MSH:D013161|UMLS:C0038000	hp.json	Splenic rupture|Ruptured spleen	http://purl.obolibrary.org/obo/HP_0012223		
GO:0003157	biolink:BiologicalProcess	endocardium development	The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.		hp.json		http://purl.obolibrary.org/obo/GO_0003157		
HP:0012224	biolink:PhenotypicFeature	Circulating immune complexes	Persistence of immune complexes in the blood circulation.	UMLS:C3887628	hp.json		http://purl.obolibrary.org/obo/HP_0012224		
HP:0012225	biolink:PhenotypicFeature	Oligodontia of primary teeth	Reduced number of primary teeth.	UMLS:C4280316|UMLS:C4022997	hp.json	Partial anodontia of primary teeth|Decreased number of baby teeth|Fewer deciduous teeth than normal|Failure of development of some deciduous teeth|Missing some primary teeth|Fewer primary teeth than normal|Failure of development of some primary teeth|Missing some milk teeth|Decreased number of deciduous teeth|Missing some baby teeth|Decreased number of primary teeth|Decreased number of milk teeth|Fewer baby teeth than normal|Partial anodontia of deciduous teeth	http://purl.obolibrary.org/obo/HP_0012225		
GO:0003156	biolink:BiologicalProcess	regulation of animal organ formation	Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.		hp.json		http://purl.obolibrary.org/obo/GO_0003156		
GO:0003159	biolink:BiologicalProcess	morphogenesis of an endothelium	The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.		hp.json		http://purl.obolibrary.org/obo/GO_0003159		
HP:0012226	biolink:PhenotypicFeature	Ovarian teratoma	The presence of a teratoma in the ovary.	UMLS:C0280131|NCIT:C3403|SNOMEDCT_US:716077006	hp.json		http://purl.obolibrary.org/obo/HP_0012226		
GO:0003158	biolink:BiologicalProcess	endothelium development	The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.		hp.json		http://purl.obolibrary.org/obo/GO_0003158		
HP:0012227	biolink:PhenotypicFeature	Urethral stricture	Narrowing of the urethra associated with inflammation or scar tissue.	SNOMEDCT_US:76618002|SNOMEDCT_US:236647003|UMLS:C0041974|MSH:D014525	hp.json		http://purl.obolibrary.org/obo/HP_0012227		
HP:0000239	biolink:PhenotypicFeature	Large fontanelles	In newborns, the two frontal bones, two parietal bones, and one occipital bone are joined by fibrous sutures, which form a small posterior fontanelle, and a larger, diamond-shaped anterior fontanelle. These regions allow for the skull to pass the birth canal and for later growth. The fontanelles gradually ossify, whereby the posterior fontanelle usually closes by eight weeks and the anterior fontanelle by the 9th to 16th month of age. Large fontanelles are diagnosed if the fontanelles are larger than age-dependent norms.	SNOMEDCT_US:276709006|UMLS:C4072822|UMLS:C4072821|UMLS:C4072820|UMLS:C0456132	hp.json	Large fontanelle|Wide fontanelles|Wide bregma sutures|Large, late-closing fontanelle|Large fontanels|Enlarged fontanelles|Large fontanel|Large bregma sutures|Persistent wide fontanel	http://purl.obolibrary.org/obo/HP_0000239		
HP:0000238	biolink:PhenotypicFeature	Hydrocephalus	Hydrocephalus is an active distension of the ventricular system of the brain resulting from inadequate passage of CSF from its point of production within the cerebral ventricles to its point of absorption into the systemic circulation.	UMLS:C0020255|SNOMEDCT_US:230745008|MSH:D006849	hp.json	Too much cerebrospinal fluid in the brain|Nonsyndromal hydrocephalus|Hydrocephaly	http://purl.obolibrary.org/obo/HP_0000238		
GO:0003152	biolink:BiologicalProcess	morphogenesis of an epithelial fold involved in embryonic heart tube formation	The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.		hp.json		http://purl.obolibrary.org/obo/GO_0003152		
GO:0003151	biolink:BiologicalProcess	outflow tract morphogenesis	The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.		hp.json		http://purl.obolibrary.org/obo/GO_0003151		
GO:0003150	biolink:BiologicalProcess	muscular septum morphogenesis	The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.		hp.json		http://purl.obolibrary.org/obo/GO_0003150		
HP:0002894	biolink:PhenotypicFeature	Neoplasm of the pancreas	A tumor (abnormal growth of tissue) of the pancreas.	UMLS:C0346647|UMLS:C0030297|SNOMEDCT_US:126859007|MSH:D010190|NCIT:C3262|SNOMEDCT_US:363418001|UMLS:C1842408	hp.json	Cancer of the pancreas|Pancreatic tumor|Pancreatic tumour|increased risk of pancreatic cancer|Pancreatic cancer|Neoplasia of the pancreas	http://purl.obolibrary.org/obo/HP_0002894		
HP:0002895	biolink:PhenotypicFeature	Papillary thyroid carcinoma	The presence of a papillary adenocarcinoma of the thyroid gland.	NCIT:C2853|SNOMEDCT_US:255029007|UMLS:C0238463|MSH:C536915	hp.json	Thyroid papillary carcinoma|Papillary carcinoma of thyroid	http://purl.obolibrary.org/obo/HP_0002895		
HP:0000230	biolink:PhenotypicFeature	Gingivitis	Inflammation of the gingiva.	MSH:D005891|UMLS:C0017574|SNOMEDCT_US:66383009	hp.json	Gingival inflammation|Inflamed gums|Red and swollen gums	http://purl.obolibrary.org/obo/HP_0000230		hposlim_core
HP:0000233	biolink:PhenotypicFeature	Thin vermilion border	Height of the vermilion of the medial part of the lip more than 2 SD below the mean, or apparently reduced height of the vermilion of the lip in the frontal view. The vermilion is the red part of the lips (and confusingly, the vermilion itself is also often referred to as being equivalent the lips).	UMLS:C0578038|SNOMEDCT_US:301348000	hp.json	Thin vermillion|Decreased volume of lip|Thin lips|Decreased volume of lip vermillion|Thin vermilion borders	http://purl.obolibrary.org/obo/HP_0000233		
HP:0000232	biolink:PhenotypicFeature	Everted lower lip vermilion	An abnormal configuration of the lower lip such that it is turned outward i.e., everted, with the Inner aspect of the lower lip vermilion (normally opposing the teeth) being visible in a frontal view.	UMLS:C1853246|UMLS:C1866234	hp.json	Everted prominent lower lip|Outward turned lower lip|Protruding lower lip|Drooping lower lip|Everted lower lip|Eclabium of lower lip	http://purl.obolibrary.org/obo/HP_0000232		hposlim_core
HP:0002893	biolink:PhenotypicFeature	Pituitary adenoma	A benign epithelial tumor derived from intrinsic cells of the adenohypophysis (anterior pituitary).	UMLS:C0032000|ICD-O:M8272/0|MSH:D010911|SNOMEDCT_US:254956000|NCIT:C2855|SNOMEDCT_US:128664001	hp.json	Pituitary gland adenoma|Noncancerous tumour in pituitary gland|Noncancerous tumor in pituitary gland	http://purl.obolibrary.org/obo/HP_0002893		
HP:0002898	biolink:PhenotypicFeature	Embryonal neoplasm		UMLS:C0027654|MSH:D009373	hp.json	Embryonal tumours|Embryonal tumors|Embryonal neoplasia	http://purl.obolibrary.org/obo/HP_0002898		
HP:0000235	biolink:PhenotypicFeature	Abnormality of the fontanelles or cranial sutures	Any abnormality of the fontanelles (the regions covered by a thick membrane that normally ossify in the first two years of life) or the cranial sutures (the fibrous joints in which the articulating bones or cartilages of the skull are connected by sutural ligaments).	UMLS:C4025876	hp.json		http://purl.obolibrary.org/obo/HP_0000235		
HP:0000234	biolink:PhenotypicFeature	Abnormality of the head	An abnormality of the head.	UMLS:C4021812	hp.json	Head abnormality|Abnormal head|Abnormality of the head	http://purl.obolibrary.org/obo/HP_0000234		
HP:0000237	biolink:PhenotypicFeature	Small anterior fontanelle	Abnormally decreased size of the anterior fontanelle with respect to age-dependent norms.	UMLS:C1859455	hp.json	Small anterior fontanel|Small forehead fontanel	http://purl.obolibrary.org/obo/HP_0000237		
HP:0002896	biolink:PhenotypicFeature	Neoplasm of the liver	A tumor (abnormal growth of tissue) of the liver.	MSH:D008113|NCIT:C3262|UMLS:C0023903|UMLS:C0345904|SNOMEDCT_US:126851005|SNOMEDCT_US:93870000	hp.json	Liver tumor|Liver tumour|Liver cancer	http://purl.obolibrary.org/obo/HP_0002896		
HP:0002897	biolink:PhenotypicFeature	Parathyroid adenoma	A benign tumor of the parathyroid gland that can cause hyperparathyroidism.	UMLS:C0262587|MSH:D010282|SNOMEDCT_US:128474007|ICD-10:D35.1|NCIT:C2855	hp.json	Parathyroid adenomas	http://purl.obolibrary.org/obo/HP_0002897		
HP:0000236	biolink:PhenotypicFeature	Abnormality of the anterior fontanelle	An abnormality of the anterior fontanelle, i.e., the cranial fontanelle that is located at the intersection of the coronal and sagittal sutures.	UMLS:C4025875	hp.json	Abnormality of the forehead soft spot	http://purl.obolibrary.org/obo/HP_0000236		
HP:0012228	biolink:PhenotypicFeature	Tension-type headache	A type of headache that last hours with continuous pain of mild or moderate intensity, bilateral location, a pressing/tightening (non-pulsating) quality and that is not aggravated by routine physical activity such as walking or climbing stairs.	UMLS:C0033893|SNOMEDCT_US:66551002|ICD-10:G44.2|MSH:D018781|SNOMEDCT_US:398057008	hp.json	Tension-type headache	http://purl.obolibrary.org/obo/HP_0012228		
HP:0012229	biolink:PhenotypicFeature	CSF pleocytosis	An increased white blood cell count in the cerebrospinal fluid.	SNOMEDCT_US:91454002|MSH:D007964|UMLS:C0151857	hp.json	Increased leukocyte count in CSF|Cerebrospinal fluid pleocytosis	http://purl.obolibrary.org/obo/HP_0012229		
HP:0002890	biolink:PhenotypicFeature	Thyroid carcinoma	The presence of a carcinoma of the thyroid gland.	NCIT:C2916|MSH:D013964|UMLS:C0549473	hp.json		http://purl.obolibrary.org/obo/HP_0002890		
HP:0002891	biolink:PhenotypicFeature	Uterine leiomyosarcoma	The presence of a leiomyosarcoma of the uterus.	NCIT:C3158|SNOMEDCT_US:447389009|UMLS:C0280631	hp.json		http://purl.obolibrary.org/obo/HP_0002891		
HP:0012210	biolink:PhenotypicFeature	Abnormal renal morphology	Any structural anomaly of the kidney.	Fyler:4512|SNOMEDCT_US:44513007|UMLS:C0266292	hp.json	Abnormal kidney morphology|Kidney structure issue|Structural kidney abnormalities|Abnormally shaped kidney|Kidney malformation|Structural renal anomalies|Structural anomalies of the renal tract|Renal malformation	http://purl.obolibrary.org/obo/HP_0012210		
HP:0012211	biolink:PhenotypicFeature	Abnormal renal physiology	An abnormal functionality of the kidney.	SNOMEDCT_US:39539005|UMLS:C0151746	hp.json	Abnormal kidney function|Kidney function issue|Abnormal renal function|Abnormality of renal physiology|Renal functional abnormality	http://purl.obolibrary.org/obo/HP_0012211		
HP:0012212	biolink:PhenotypicFeature	Abnormal glomerular filtration rate	An abnormally increased or reduced amount of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time.	UMLS:C0854050	hp.json	Abnormal GFR	http://purl.obolibrary.org/obo/HP_0012212		
HP:0012213	biolink:PhenotypicFeature	Decreased glomerular filtration rate	An abnormal reduction in the volume of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time.	UMLS:C0853068	hp.json	Reduced creatinine clearance|Impaired renal creatinine clearance|Decreased GFR	http://purl.obolibrary.org/obo/HP_0012213		
GO:0003168	biolink:BiologicalProcess	Purkinje myocyte differentiation	The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.		hp.json	cardiac Purkinje fiber cell differentiation	http://purl.obolibrary.org/obo/GO_0003168		
HP:0012214	biolink:PhenotypicFeature	Increased glomerular filtration rate	An abnormal rise in the volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time.	UMLS:C0856948	hp.json	Increased GFR	http://purl.obolibrary.org/obo/HP_0012214		
HP:0012215	biolink:PhenotypicFeature	Testicular microlithiasis	The deposition of calcium phosphate microliths within the seminiferous tubules.	MSH:C566478|UMLS:C1864873|SNOMEDCT_US:117261000119108	hp.json		http://purl.obolibrary.org/obo/HP_0012215		
HP:0012216	biolink:PhenotypicFeature	Entrapment neuropathy of suprascapular nerve	An entrapment neuropathy of the suprascapular nerve, presenting with shoulder weakness confined to the supraspinatus muscle (this muscle initiates shoulder abduction) or to the infraspinatus (this muscle externally rotates the arm), as well as with pain in the posterior part of the shoulder and upper periscapular region.	SNOMEDCT_US:230635000|UMLS:C0393890	hp.json	Suprascapular nerve entrapment	http://purl.obolibrary.org/obo/HP_0012216		
GO:0003169	biolink:BiologicalProcess	coronary vein morphogenesis	The process in which the anatomical structures of veins of the heart are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0003169		
GO:0003164	biolink:BiologicalProcess	His-Purkinje system development	The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.		hp.json		http://purl.obolibrary.org/obo/GO_0003164		
GO:0003163	biolink:BiologicalProcess	sinoatrial node development	The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.		hp.json	sinus node development|SAN development|SA node development	http://purl.obolibrary.org/obo/GO_0003163		
GO:0003165	biolink:BiologicalProcess	Purkinje myocyte development	The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.		hp.json	cardiac Purkinje fiber development	http://purl.obolibrary.org/obo/GO_0003165		
GO:0003160	biolink:BiologicalProcess	endocardium morphogenesis	The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.		hp.json		http://purl.obolibrary.org/obo/GO_0003160		
GO:0003162	biolink:BiologicalProcess	atrioventricular node development	The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.		hp.json	AV node development	http://purl.obolibrary.org/obo/GO_0003162		
GO:0003161	biolink:BiologicalProcess	cardiac conduction system development	The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.		hp.json	heart conduction system development|cardiac impulse conducting system development	http://purl.obolibrary.org/obo/GO_0003161		
HP:0000242	biolink:PhenotypicFeature	Parietal bossing	Parietal bossing is a marked prominence in the parietal region.	UMLS:C1857126	hp.json	Bossing of parietal bone|Biparietal bossing	http://purl.obolibrary.org/obo/HP_0000242		
HP:0000244	biolink:PhenotypicFeature	Brachyturricephaly	Abnormal vertical height of the skull and a shortening of its anterior-posterior length, frequently combined with malformations of the occipital region.	UMLS:C1857484	hp.json	Brachy-turricephaly|Turribrachycephaly|High, prominent forehead	http://purl.obolibrary.org/obo/HP_0000244		
HP:0000243	biolink:PhenotypicFeature	Trigonocephaly	Wedge-shaped, or triangular head, with the apex of the triangle at the midline of the forehead and the base of the triangle at the occiput.	MSH:D003398|UMLS:C4280666|UMLS:C4280665|SNOMEDCT_US:28740008|UMLS:C0265535	hp.json	Wedge shaped cranium|Wedge shaped head|Triangular skull shape|Triangular cranium shape|Triangular head shape|Wedge shaped skull	http://purl.obolibrary.org/obo/HP_0000243		hposlim_core
HP:0000246	biolink:PhenotypicFeature	Sinusitis	Inflammation of the paranasal sinuses owing to a viral, bacterial, or fungal infection, allergy, or an autoimmune reaction.	MSH:D010254|SNOMEDCT_US:7393007|UMLS:C0037199|UMLS:C0030469|MSH:D012852|SNOMEDCT_US:36971009	hp.json	Sinus disease|Sinus infection|Sinus inflammation	http://purl.obolibrary.org/obo/HP_0000246		hposlim_core
HP:0000245	biolink:PhenotypicFeature	Abnormal paranasal sinus morphology	Abnormality of the paranasal (cranial) sinuses, which are air-filled spaces that are located within the bones of the skull and face and communicate with the nasal cavity. They comprise the maxillary sinuses, the frontal sinuses, the ethmoid sinuses, and the sphenoid sinuses.	UMLS:C4025873	hp.json	Abnormality of the paranasal sinuses|Abnormality of the sinuses of the head|Abnormality of the sinuses	http://purl.obolibrary.org/obo/HP_0000245		
HP:0000248	biolink:PhenotypicFeature	Brachycephaly	An abnormality of skull shape characterized by a decreased anterior-posterior diameter. That is, a cephalic index greater than 81%. Alternatively, an apparently shortened anteroposterior dimension (length) of the head compared to width.	UMLS:C4072824|MSH:D003398|UMLS:C0221356|UMLS:C4072823|SNOMEDCT_US:13649004	hp.json	Short and broad skull|Wide skull shape|Broad skull shape|Broad head shape|Wide head shape|Wide cranium shape|Broad cranium shape	http://purl.obolibrary.org/obo/HP_0000248		hposlim_core
HP:0012217	biolink:PhenotypicFeature	Increased urinary porphobilinogen	Increased concentration of porphobilinogen in the urine.	UMLS:C4023000	hp.json		http://purl.obolibrary.org/obo/HP_0012217		
HP:0012218	biolink:PhenotypicFeature	Alveolar soft part sarcoma	A type of soft tissue sarcoma with a histological appearance reminiscent of alveoli because of its reticulated fibrous stroma enclosing groups of sarcoma cells, which resemble epithelial cells and are enclosed in alveoli walled with connective tissue.	SNOMEDCT_US:88195001|MSH:D018234|SNOMEDCT_US:404056007|UMLS:C0206657	hp.json		http://purl.obolibrary.org/obo/HP_0012218		
HP:0012219	biolink:PhenotypicFeature	Erythema nodosum	An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral.	UMLS:C0014743|MSH:D004893|SNOMEDCT_US:32861005	hp.json		http://purl.obolibrary.org/obo/HP_0012219		
HP:0000240	biolink:PhenotypicFeature	Abnormality of skull size	Any abnormality of the size of the skull.	UMLS:C4025874	hp.json	Abnormality of skull size|Abnormality of cranium size|Abnormality of head size	http://purl.obolibrary.org/obo/HP_0000240		
HP:0012200	biolink:PhenotypicFeature	Abnormality of prothrombin	An anomaly of clotting factor II, which is known as prothrombin, a vitamin K-dependent proenzyme that functions in the blood coagulation cascade.	UMLS:C4023005	hp.json		http://purl.obolibrary.org/obo/HP_0012200		
HP:0012201	biolink:PhenotypicFeature	obsolete Reduced prothrombin activity			hp.json		http://purl.obolibrary.org/obo/HP_0012201		
GO:0005798	biolink:CellularComponent	Golgi-associated vesicle	Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.	NIF_Subcellular:sao819927218	hp.json	Golgi vesicle|vesicular component	http://purl.obolibrary.org/obo/GO_0005798		
HP:0012202	biolink:PhenotypicFeature	Increased serum bile acid concentration	An increase in the concentration of bile acid in the blood.	UMLS:C4023004	hp.json		http://purl.obolibrary.org/obo/HP_0012202		
HP:0012203	biolink:PhenotypicFeature	Onychomycosis	A fungal infection of the toenails or fingernails that tends to cause the nails to thicken, discolor, disfigure, and split.	MSH:D014009|UMLS:C0040261|SNOMEDCT_US:414941008	hp.json		http://purl.obolibrary.org/obo/HP_0012203		
HP:0012204	biolink:PhenotypicFeature	Recurrent vulvovaginal candidiasis	Recurrent infection involving the vulva, vagina, and adjacent crural areas, whereby the causative agent belongs to the genus Candida.	UMLS:C4023003	hp.json		http://purl.obolibrary.org/obo/HP_0012204		
HP:0012205	biolink:PhenotypicFeature	Globozoospermia	Any structural anomaly of the acrosome resulting in a round sperm head.	UMLS:C0403825|MSH:D000072660|SNOMEDCT_US:236818008	hp.json		http://purl.obolibrary.org/obo/HP_0012205		
HP:0000217	biolink:PhenotypicFeature	Xerostomia	Dryness of the mouth due to salivary gland dysfunction.	SNOMEDCT_US:87715008|MSH:D014987|SNOMEDCT_US:56893005|SNOMEDCT_US:300268000|UMLS:C0043352	hp.json	Dry mouth syndrome|Decreased salivary flow|Reduced salivation|Dry mouth	http://purl.obolibrary.org/obo/HP_0000217		hposlim_core
GO:0005794	biolink:CellularComponent	Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.	NIF_Subcellular:sao451912436|Wikipedia:Golgi_apparatus	hp.json	Golgi complex|Golgi ribbon|Golgi	http://purl.obolibrary.org/obo/GO_0005794		goslim_pir|goslim_plant|goslim_drosophila|goslim_aspergillus|goslim_chembl|goslim_mouse|goslim_yeast|goslim_candida|goslim_agr|goslim_generic
HP:0000216	biolink:PhenotypicFeature	Broad secondary alveolar ridge		UMLS:C1839276	hp.json	Secondary alveolar ridges	http://purl.obolibrary.org/obo/HP_0000216		
HP:0002878	biolink:PhenotypicFeature	Respiratory failure	A severe form of respiratory insufficiency characterized by inadequate gas exchange such that the levels of oxygen or carbon dioxide cannot be maintained within normal limits.	SNOMEDCT_US:409622000|MSH:D012131|UMLS:C1145670	hp.json	Respiratory failure	http://purl.obolibrary.org/obo/HP_0002878		
GO:0003133	biolink:BiologicalProcess	endodermal-mesodermal cell signaling	Any process that mediates the transfer of information from endodermal cells to mesodermal cells.		hp.json	endodermal-mesodermal cell signalling	http://purl.obolibrary.org/obo/GO_0003133		
HP:0000219	biolink:PhenotypicFeature	Thin upper lip vermilion	Height of the vermilion of the upper lip in the midline more than 2 SD below the mean. Alternatively, an apparently reduced height of the vermilion of the upper lip in the frontal view (subjective).	UMLS:C1865017	hp.json	Thin vermilion border of upper lip|Decreased volume of upper lip|Thin red part of the upper lip|Thin upper lips|Decreased height of upper lip vermilion|Thin upper lip|Decreased volume of upper lip vermilion	http://purl.obolibrary.org/obo/HP_0000219		hposlim_core
HP:0000218	biolink:PhenotypicFeature	High palate	Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective).	UMLS:C0240635|SNOMEDCT_US:27272007	hp.json	Palate, high-arched|Elevated palate|High arched palate|Increased palatal height|Ogival palate|High, arched palate|High palate|Palate high-arched|High-arched palate	http://purl.obolibrary.org/obo/HP_0000218		
HP:0002879	biolink:PhenotypicFeature	Anisospondyly	Abnormally increased variability of the size of the vertebral bodies.	UMLS:C1857101	hp.json		http://purl.obolibrary.org/obo/HP_0002879		
HP:0002872	biolink:PhenotypicFeature	Apneic episodes precipitated by illness, fatigue, stress	Recurrent episodes of apnea that are precipitated by factors such as illness, fatigue, or stress.	UMLS:C3806462	hp.json	Episodic apnea induced by febrile illness or stress	http://purl.obolibrary.org/obo/HP_0002872		
HP:0000211	biolink:PhenotypicFeature	Trismus	Limitation in the ability to open the mouth.	UMLS:C0041105|MSH:D014313|UMLS:C1848474|UMLS:C4228933|SNOMEDCT_US:87866006|UMLS:C4280672	hp.json	Limited jaw movement|Decrease in jaw mobility|Limited jaw opening|Lockjaw|Limited jaw mobility|Decrease in jaw opening|Decrease in mandibular opening|Decrease in mandibular movement|Limited mandibular mobility|Limited mandibular opening|Decrease in mandibular mobility|Limited mouth opening|Decrease in jaw movement|Pain of muscles of mastication	http://purl.obolibrary.org/obo/HP_0000211		
HP:0002870	biolink:PhenotypicFeature	Obstructive sleep apnea	A condition characterized by obstruction of the airway and by pauses in breathing during sleep occurring many times during the night. Obstructive sleep apnea is related to a relaxation of muscle tone (which normally occurs during sleep) leading to partial collapse of the soft tissues in the airway with resultant obstruction of the air flow.	UMLS:C0520679|MSH:D020181|SNOMEDCT_US:78275009	hp.json	Obstructive sleep apnoea	http://purl.obolibrary.org/obo/HP_0002870		
HP:0002871	biolink:PhenotypicFeature	Central apnea	Apnea resulting from depression of the respiratory centers in the medulla oblongata. There is a lack of respiratory effort rather than obstruction of airflow.	MSH:D020182|UMLS:C0520680	hp.json	Central apnoea	http://purl.obolibrary.org/obo/HP_0002871		
HP:0002876	biolink:PhenotypicFeature	Episodic tachypnea	Episodes of very rapid breathing.	UMLS:C3806218	hp.json	Hyperpnea, episodic	http://purl.obolibrary.org/obo/HP_0002876		
HP:0000212	biolink:PhenotypicFeature	Gingival overgrowth	Hyperplasia of the gingiva (that is, a thickening of the soft tissue overlying the alveolar ridge. The degree of thickening ranges from involvement of the interdental papillae alone to gingival overgrowth covering the entire tooth crown.	UMLS:C0376480|SNOMEDCT_US:54711002|MSH:D005886|MSH:D005885|SNOMEDCT_US:441787004|MSH:D019214|UMLS:C0017567|SNOMEDCT_US:441798003|UMLS:C0017566	hp.json	Gingival enlargement|Gum hypertrophy|Gum enlargement|Oral soft tissue hyperplasia|Hypertrophic gingivitis|Gingival hyperplasia	http://purl.obolibrary.org/obo/HP_0000212		hposlim_core
HP:0002877	biolink:PhenotypicFeature	Nocturnal hypoventilation	An abnormal reduction in alveolar ventilation occuring during sleep. This is characterized by a rise in arterial carbon dioxide.	UMLS:C1843643	hp.json	Nocturnal slow breathing|Nocturnal under breathing|Hypoventilation during sleep|Nocturnal hypopnea	http://purl.obolibrary.org/obo/HP_0002877		
HP:0000215	biolink:PhenotypicFeature	Thick upper lip vermilion	Height of the vermilion of the upper lip in the midline more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the upper lip in the frontal view (subjective).	UMLS:C1846423	hp.json	Thick upper lip|Prominent upper lip|Full upper lip|Increased height of upper lip vermilion|Increased volume of upper lip|Increased volume of upper lip vermilion|Thick vermilion border of upper lip|Plump upper lip|Full upper lip vermilion|Prominent upper lip vermilion|Thick red part of the upper lip	http://purl.obolibrary.org/obo/HP_0000215		hposlim_core
HP:0000214	biolink:PhenotypicFeature	Lip telangiectasia	Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the lips.	UMLS:C1857697|UMLS:C4280671|UMLS:C4280670	hp.json	Labial angioectasias|Telangiectasia of the lips|Angioectasias of the lip|Spider veins of the lip|Lip telangiectases|Labial telangiectasia	http://purl.obolibrary.org/obo/HP_0000214		
CHEBI:134249	biolink:ChemicalSubstance	alkanesulfonate oxoanion	An alkanesulfonate in which the carbon at position 1 is attached to R, which can represent hydrogens, a carbon chain, or other groups.	MetaCyc:Alkanesulfonates	hp.json	alkanesulfonate oxoanions|an alkanesulfonate|alkanesulfonates	http://purl.obolibrary.org/obo/CHEBI_134249		3_STAR
HP:0002875	biolink:PhenotypicFeature	Exertional dyspnea	Perceived difficulty to breathe that occurs with exercise or exertion and improves with rest.	SNOMEDCT_US:60845006|UMLS:C0231807	hp.json	Shortness of breathing upon physical activity|Exertional dyspnoea|Exertional breathlessness	http://purl.obolibrary.org/obo/HP_0002875		
HP:0012206	biolink:PhenotypicFeature	Abnormal sperm motility	An anomaly of the mobility of ejaculated sperm.	UMLS:C0855512	hp.json	Abnormal sperm motility	http://purl.obolibrary.org/obo/HP_0012206		
HP:0012207	biolink:PhenotypicFeature	Reduced sperm motility	An abnormal reduction in the mobility of ejaculated sperm.	UMLS:C4023002	hp.json	Reduced sperm motility|Asthenospermia	http://purl.obolibrary.org/obo/HP_0012207		
HP:0012208	biolink:PhenotypicFeature	Immotile sperm	A lack of mobility of ejaculated sperm.	UMLS:C4023001	hp.json	Nonmotile sperm	http://purl.obolibrary.org/obo/HP_0012208		
HP:0012209	biolink:PhenotypicFeature	Juvenile myelomonocytic leukemia	Juvenile myelomonocytic leukemia (JMML) is a lethal myeloproliferative disease of young childhood characterized clinically by overproduction of myelomonocytic cells and by the in vitro phenotype of hematopoietic progenitor hypersensitivity to granulocyte-macrophage colony-stimulating factor.	SNOMEDCT_US:445227008|SNOMEDCT_US:128832006|UMLS:C0349639|SNOMEDCT_US:277587001|MSH:D054429	hp.json	Juvenile myelomonocytic leukaemia	http://purl.obolibrary.org/obo/HP_0012209		
GO:0003149	biolink:BiologicalProcess	membranous septum morphogenesis	The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.		hp.json		http://purl.obolibrary.org/obo/GO_0003149		
GO:0003145	biolink:BiologicalProcess	embryonic heart tube formation via epithelial folding	The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis.		hp.json		http://purl.obolibrary.org/obo/GO_0003145		
GO:0003148	biolink:BiologicalProcess	outflow tract septum morphogenesis	The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.		hp.json		http://purl.obolibrary.org/obo/GO_0003148		
GO:0003147	biolink:BiologicalProcess	neural crest cell migration involved in heart formation	The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.		hp.json		http://purl.obolibrary.org/obo/GO_0003147		
GO:0003142	biolink:BiologicalProcess	cardiogenic plate morphogenesis	The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.		hp.json	cardiac crescent morphogenesis	http://purl.obolibrary.org/obo/GO_0003142		
HP:0000228	biolink:PhenotypicFeature	Oral cavity telangiectasia	Presence of telangiectases in the oral cavity.	UMLS:C4025877|UMLS:C4280667	hp.json	Angioectasias of the oral cavity|Angioectasias of the mouth|Spider veins of the oral cavity|Oral cavity teleangiectasia|Spider veins of the mouth	http://purl.obolibrary.org/obo/HP_0000228		
HP:0000227	biolink:PhenotypicFeature	Tongue telangiectasia	Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the tongue.	UMLS:C4025878|UMLS:C4280668	hp.json	Spider veins of the tongue|Lingual angioectasias|Lingual telangiectasia|Angioectasias of the tongue	http://purl.obolibrary.org/obo/HP_0000227		
GO:0003144	biolink:BiologicalProcess	embryonic heart tube formation	The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003144		
GO:0003143	biolink:BiologicalProcess	embryonic heart tube morphogenesis	The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003143		
HP:0002883	biolink:PhenotypicFeature	Hyperventilation	Hyperventilation refers to an increased pulmonary ventilation rate that is faster than necessary for the exchange of gases. Hyperventilation can result from increased frequency of breathing, an increased tidal volume, or both, and leads to an excess intake of oxygen and the blowing off of carbon dioxide.	MSH:D006985|SNOMEDCT_US:68978004|UMLS:C0020578	hp.json	Rapid breathing	http://purl.obolibrary.org/obo/HP_0002883		
HP:0000220	biolink:PhenotypicFeature	Velopharyngeal insufficiency	Inability of velopharyngeal sphincter to sufficiently separate the nasal cavity from the oral cavity during speech.	SNOMEDCT_US:229727006|UMLS:C0042454|UMLS:C4280669|MSH:D014681|SNOMEDCT_US:278714002|SNOMEDCT_US:232416001	hp.json	Velopharyngeal dysfunction|Velopharyngeal incompetence	http://purl.obolibrary.org/obo/HP_0000220		
HP:0002884	biolink:PhenotypicFeature	Hepatoblastoma	A kind of neoplasm of the liver that originates from immature liver precursor cells and macroscopically is composed of tissue resembling fetal or mature liver cells or bile ducts.	SNOMEDCT_US:45024009|SNOMEDCT_US:109843000|UMLS:C0206624|MSH:D018197|NCIT:C3728	hp.json		http://purl.obolibrary.org/obo/HP_0002884		
HP:0000222	biolink:PhenotypicFeature	Gingival hyperkeratosis	Hyperkeratosis of the gingiva.	UMLS:C1857013	hp.json	Hyperkeratosis, gingival	http://purl.obolibrary.org/obo/HP_0000222		
HP:0000221	biolink:PhenotypicFeature	Furrowed tongue	Accentuation of the grooves on the dorsal surface of the tongue.	MSH:D014063|SNOMEDCT_US:52368004|UMLS:C0040412	hp.json	Lingue plicata|Plicated tongue|Lingual furrow|Prominent tongue grooves|Fissured tongue|Grooved tongue|Scrotal tongue	http://purl.obolibrary.org/obo/HP_0000221		hposlim_core
HP:0002882	biolink:PhenotypicFeature	Sudden episodic apnea	Recurrent bouts of sudden, severe apnea that may be life-threatening.	UMLS:C4025671	hp.json		http://purl.obolibrary.org/obo/HP_0002882		
HP:0000224	biolink:PhenotypicFeature	Hypogeusia	A decreased ability to perceive flavor.	SNOMEDCT_US:697990000|MSH:D000370|UMLS:C0151934	hp.json	Decreased taste sensation|Decreased taste	http://purl.obolibrary.org/obo/HP_0000224		
HP:0002888	biolink:PhenotypicFeature	Ependymoma	The presence of an ependymoma of the central nervous system.	SNOMEDCT_US:443643007|NCIT:C3017|UMLS:C0014474|MSH:D004806|SNOMEDCT_US:57706008	hp.json		http://purl.obolibrary.org/obo/HP_0002888		
HP:0000223	biolink:PhenotypicFeature	Abnormality of taste sensation		UMLS:C4025879	hp.json	Abnormality of taste sensation	http://purl.obolibrary.org/obo/HP_0000223		
HP:0002885	biolink:PhenotypicFeature	Medulloblastoma	A rapidly growing embryonic tumor arising in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle in children. More rarely, medulloblastoma arises in the cerebellum in adults.	MSH:D008527|SNOMEDCT_US:443333004|UMLS:C0025149|SNOMEDCT_US:83217000|NCIT:C3222	hp.json		http://purl.obolibrary.org/obo/HP_0002885		
HP:0000225	biolink:PhenotypicFeature	Gingival bleeding	Hemorrhage affecting the gingiva.	MSH:D005884|SNOMEDCT_US:86276007|UMLS:C0017565	hp.json	Gingivorrhagia|Gingival hemorrhage|Gingival haemorrhage|Bleeding gums	http://purl.obolibrary.org/obo/HP_0000225		
HP:0002886	biolink:PhenotypicFeature	Vagal paraganglioma	A tumor that develops in the retrostyloid compartment of the parapharyngeal space, arising from an island of paraganglion tissue derived from the neural crest that is located on the vagus nerve.	UMLS:C0474819|SNOMEDCT_US:253030004	hp.json	Glomus vagale tumor|Glomus vagale paraganglioma|Vagal nerve tumours|Vagal nerve tumors|Glomus vagale tumour	http://purl.obolibrary.org/obo/HP_0002886		
HP:0002880	biolink:PhenotypicFeature	obsolete Respiratory difficulties			hp.json		http://purl.obolibrary.org/obo/HP_0002880		
CHEBI:134251	biolink:ChemicalSubstance	guaiacols	Any phenol carrying an additional methoxy substituent at the ortho-position.	MetaCyc:Guaiacols	hp.json	1-hydroxy-2-methoxybenzenes|2-methoxyphenol|catechol monomethyl ether|ortho-methoxyphenols|o-methoxyphenol|a guaiacol|2-methoxyphenol derivatives|o-methoxyphenols|2-methoxyphenol derivative|ortho-methoxyphenol|2-methoxyphenols|catechol monomethyl ethers	http://purl.obolibrary.org/obo/CHEBI_134251		3_STAR
HP:0012264	biolink:PhenotypicFeature	Absent central microtubular pair morphology of respiratory motile cilia	Absence of the two central microtubules of motile cilia with a 9+2 microtubuluar configuration.	UMLS:C4022982	hp.json		http://purl.obolibrary.org/obo/HP_0012264		
HP:0012265	biolink:PhenotypicFeature	Ciliary dyskinesia	A deviation from the normally well coordinated pattern of intracellular and intercellular synchrony of motile cilia. Dyskinetic cilia usually beat out of synchrony relative to neighboring cilia.	SNOMEDCT_US:86204009|MSH:D002925|UMLS:C0008780	hp.json	Lack of coordinated beating of respiratory cilia	http://purl.obolibrary.org/obo/HP_0012265		
HP:0012266	biolink:PhenotypicFeature	T-wave alternans	A periodic beat-to-beat variation in the amplitude or shape of the T wave in an EKG.	UMLS:C1998313|SNOMEDCT_US:428550008	hp.json		http://purl.obolibrary.org/obo/HP_0012266		
HP:0012267	biolink:PhenotypicFeature	Absent respiratory ciliary axoneme radial spokes	Absence of the radial spokes of the axoneme of the respiratory cilium.	UMLS:C4022981	hp.json		http://purl.obolibrary.org/obo/HP_0012267		
HP:0012268	biolink:PhenotypicFeature	Myxoid liposarcoma	A liposarcoma that contains myxomatous tissue.	UMLS:C0206634|SNOMEDCT_US:404069006|SNOMEDCT_US:27849002|MSH:D018208	hp.json		http://purl.obolibrary.org/obo/HP_0012268		
HP:0012269	biolink:PhenotypicFeature	Abnormal muscle glycogen content	Any anomaly in the amount of glycogen in muscle tissue.	UMLS:C4022980	hp.json		http://purl.obolibrary.org/obo/HP_0012269		
GO:0005774	biolink:CellularComponent	vacuolar membrane	The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.		hp.json		http://purl.obolibrary.org/obo/GO_0005774		
GO:0005775	biolink:CellularComponent	vacuolar lumen	The volume enclosed within the vacuolar membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0005775		
GO:0005773	biolink:CellularComponent	vacuole	A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.	Wikipedia:Vacuole	hp.json	vacuolar carboxypeptidase Y	http://purl.obolibrary.org/obo/GO_0005773		goslim_pir|goslim_plant|goslim_flybase_ribbon|goslim_drosophila|goslim_chembl|goslim_aspergillus|goslim_mouse|goslim_agr|goslim_yeast|goslim_candida|goslim_generic
HP:0012260	biolink:PhenotypicFeature	Abnormal central microtubular pair morphology of respiratory motile cilia	A structural anomaly of the two central microtubules of motile cilia with a 9+2 microtubuluar configuration.	UMLS:C4022985	hp.json		http://purl.obolibrary.org/obo/HP_0012260		
HP:0012261	biolink:PhenotypicFeature	Abnormal respiratory motile cilium physiology	Any functional anomaly of the respiratory motile cilia.	UMLS:C4022984	hp.json		http://purl.obolibrary.org/obo/HP_0012261		
HP:0012262	biolink:PhenotypicFeature	Abnormal ciliary motility	Any anomaly of the normal motility of motile cilia. Evaluation of ciliary beat frequency and ciliary beat pattern requires high-speed videomicroscopy of freshly obtained ciliary biopsies that are maintained in culture media under controlled conditions.	UMLS:C4022983	hp.json		http://purl.obolibrary.org/obo/HP_0012262		
HP:0012263	biolink:PhenotypicFeature	Immotile cilia		UMLS:C1855672	hp.json		http://purl.obolibrary.org/obo/HP_0012263		
HP:0000275	biolink:PhenotypicFeature	Narrow face	Bizygomatic (upper face) and bigonial (lower face) width are both more than 2 standard deviations below the mean (objective); or, an apparent reduction in the width of the upper and lower face (subjective).	UMLS:C1837463|UMLS:C1849121	hp.json	Transverse hypoplasia of face|Narrow face|Thin face|Horizontal deficiency of face|Transverse insufficiency of face|Decreased horizontal dimension of face|Narrow facies|Horizontal hypoplasia of face|Thin facies|Decreased breadth of face|Decreased transverse dimension of face|Transverse deficiency of face|Horizontal insufficiency of face|Decreased width of face	http://purl.obolibrary.org/obo/HP_0000275		hposlim_core
HP:0000274	biolink:PhenotypicFeature	Small face	A face that is short (HP:0011219) and narrow (HP:0000275).	UMLS:C1855538	hp.json	Hypoplasia of face|Facial hypoplasia|Small facies|Small face|Short and narrow face|Microfacies|Microface	http://purl.obolibrary.org/obo/HP_0000274		
HP:0000277	biolink:PhenotypicFeature	Abnormal mandible morphology	Any abnormality of the mandible, the bone of the lower jaw.	UMLS:C4025870	hp.json	Abnormality of the lower jaw bone|Anomaly of the mandible|Deformity of the lower jaw bone|Malformation of the lower jaw bone|Abnormality of the mandible|Deformity of the mandible|Malformation of the mandible	http://purl.obolibrary.org/obo/HP_0000277		hposlim_core
HP:0000276	biolink:PhenotypicFeature	Long face	Facial height (length) is more than 2 standard deviations above the mean (objective); or, an apparent increase in the height (length) of the face (subjective).	UMLS:C1836047	hp.json	Increased vertical dimension of face|Vertical Facial Excess|Vertical hyperplasia of face|Long face|Vertical enlargement of face|Increased height of face|Vertical overgrowth of face|Elongation of face|Increased length of face|Vertical excess of face|Long facies|Vertical elongation of face	http://purl.obolibrary.org/obo/HP_0000276		hposlim_core
HP:0000278	biolink:PhenotypicFeature	Retrognathia	An abnormality in which the mandible is mislocalised posteriorly.	UMLS:C3494422|MSH:D063173	hp.json	Retrognathia of lower jaw|Retrogenia|Receding mandible|Weak chin|Lower jaw retrognathia|Weak jaw|Receding chin|Receding lower jaw	http://purl.obolibrary.org/obo/HP_0000278		hposlim_core
CHEBI:136889	biolink:ChemicalSubstance	5beta steroid	Any steroid that has beta-configuration at position 5.		hp.json	5beta-steroids|5beta-steroid|5beta steroids	http://purl.obolibrary.org/obo/CHEBI_136889		3_STAR
UBERON:0007617	biolink:AnatomicalEntity	synovial cavity of joint	An anatomical cavity that surrounded_by a synovial joint.	FMA:11356	hp.json	joint cavity|cavitas articularis (junctura synovialis)|articular cavity (synovial joint)|cavity of synovial joint|synovial cavity	http://purl.obolibrary.org/obo/UBERON_0007617		
UBERON:0007616	biolink:AnatomicalEntity	layer of synovial tissue	A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO].	FMA:66762|BTO:0001338|CALOHA:TS-0998	hp.json	stratum synoviale|synovial tissue|synovial membrane|synovium|synovial layer	http://purl.obolibrary.org/obo/UBERON_0007616		
HP:0000271	biolink:PhenotypicFeature	Abnormality of the face	An abnormality of the face.	UMLS:C0266617|SNOMEDCT_US:118930001|UMLS:C4025871|SNOMEDCT_US:398302004|UMLS:C1290857|SNOMEDCT_US:32003007|SNOMEDCT_US:398206004	hp.json	Abnormal face|Facial anomaly|Disorder of face|Disorder of the face|Abnormality of the face|Anomaly of face|Anomaly of the face|Abnormality of the physiognomy|Abnormality of the visage|Facial abnormality|Abnormality of the countenance	http://purl.obolibrary.org/obo/HP_0000271		hposlim_core
HP:0000270	biolink:PhenotypicFeature	Delayed cranial suture closure	Infants normally have two fontanels at birth, the diamond-shaped anterior fontanelle at the junction of the coronal and sagittal sutures, and the posterior fontanelle at the intersection of the occipital and parietal bones. The posterior fontanelle usually closes by the 8th week of life, and the anterior fontanel closes by the 18th month of life on average. This term applies if there is delay of closure of the fontanelles beyond the normal age.	UMLS:C0277828|SNOMEDCT_US:82779003	hp.json	Open sutures|Late closure of fontanelle|Delayed fontanelle closure|Late closing fontanelles|Delayed closure of the fontanelles|Delayed closure of fontanelles|Broad late closing cranial sutures|Late-closing fontanelle|Delayed cranial suture closure|Delayed fontanel closure|Delayed closure of fontanels|Delayed closure of fontanel	http://purl.obolibrary.org/obo/HP_0000270		
HP:0000273	biolink:PhenotypicFeature	Facial grimacing		UMLS:C0234853|SNOMEDCT_US:37126005	hp.json	Facial grimacing	http://purl.obolibrary.org/obo/HP_0000273		
HP:0000272	biolink:PhenotypicFeature	Malar flattening	Underdevelopment of the malar prominence of the jugal bone (zygomatic bone in mammals), appreciated in profile, frontal view, and/or by palpation.	UMLS:C4280651|UMLS:C1858085	hp.json	Zygomatic flattening|Underdevelopment of malar bone|Flat cheekbone|Hypotrophic malar bone|Malar hypoplasia|Depressed malar region|Decreased size of malar bone	http://purl.obolibrary.org/obo/HP_0000272		hposlim_core
UBERON:0007610	biolink:AnatomicalEntity	tibial artery	The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and pes. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.	NCIT:C12824|EMAPA:36530|MA:0002067|UMLS:C0085427|MESH:D016909|GAID:514	hp.json		http://purl.obolibrary.org/obo/UBERON_0007610		
HP:0012253	biolink:PhenotypicFeature	Abnormal respiratory epithelium morphology	Any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.	UMLS:C4022991	hp.json		http://purl.obolibrary.org/obo/HP_0012253		
HP:0012254	biolink:PhenotypicFeature	Ewing sarcoma	A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones.	SNOMEDCT_US:76909002|UMLS:C0553580|MSH:D012512	hp.json	Ewing's sarcoma	http://purl.obolibrary.org/obo/HP_0012254		
HP:0012255	biolink:PhenotypicFeature	Dynein arm defect of respiratory motile cilia	An anomaly of the dynein arms of motile cilia. This feature is usually appreciated by electron microscopy.	UMLS:C4022990	hp.json		http://purl.obolibrary.org/obo/HP_0012255		
HP:0012256	biolink:PhenotypicFeature	Absent outer dynein arms	Absence of the outer dynein arms of respiratory motile cilia, which normally are situated outside of the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy.	UMLS:C4022989	hp.json		http://purl.obolibrary.org/obo/HP_0012256		
HP:0012257	biolink:PhenotypicFeature	Absent inner dynein arms	Absence of the inner dynein arms of respiratory motile cilia, which normally are situated within the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy.	UMLS:C4022988	hp.json		http://purl.obolibrary.org/obo/HP_0012257		
HP:0012258	biolink:PhenotypicFeature	Abnormal axonemal organization of respiratory motile cilia	Abnormal arrangement of the structures of the axoneme, which is the cytoskeletal structure that forms the inner core of the motile cilium and displays a canonical 9+2 microtubular pattern of motile cilia studded with dynein arms.	UMLS:C4022987	hp.json	Abnormal axonemal organisation of respiratory motile cilia	http://purl.obolibrary.org/obo/HP_0012258		
HP:0012259	biolink:PhenotypicFeature	Absent inner and outer dynein arms	Complete absence of the dynein arms of respiratory motile cilia, that is, absence of the inner and the outer dynein arms, which normally are situated inside and outside of the peripheral microtubules of motile cilia. This feature is usually appreciated by electron microscopy.	UMLS:C4022986	hp.json		http://purl.obolibrary.org/obo/HP_0012259		
GO:0030720	biolink:BiologicalProcess	oocyte localization involved in germarium-derived egg chamber formation	Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber.		hp.json	oogenesis, oocyte localization|oogenesis, establishment and maintenance of oocyte localization|oocyte localization during oogenesis|establishment and maintenance of oocyte position during oogenesis|oocyte localization during germarium-derived egg chamber formation|establishment and maintenance of oocyte localization in egg chamber|oocyte localisation involved in germarium-derived egg chamber formation|oocyte positioning during oogenesis	http://purl.obolibrary.org/obo/GO_0030720		
HP:0012250	biolink:PhenotypicFeature	ST segment depression	An electrocardiographic anomaly in which the ST segment is observed to be located inferior to the isoelectric line.	SNOMEDCT_US:429622005|SNOMEDCT_US:26141007|UMLS:C0520887	hp.json		http://purl.obolibrary.org/obo/HP_0012250		
HP:0012251	biolink:PhenotypicFeature	ST segment elevation	An electrocardiographic anomaly in which the ST segment is observed to be located superior to the isoelectric line.	SNOMEDCT_US:164931005|SNOMEDCT_US:76388001|UMLS:C0520886	hp.json		http://purl.obolibrary.org/obo/HP_0012251		
HP:0012252	biolink:PhenotypicFeature	Abnormal respiratory system morphology	A structural anomaly of the respiratory system.	Fyler:4235|UMLS:C4022992	hp.json		http://purl.obolibrary.org/obo/HP_0012252		
HP:0000286	biolink:PhenotypicFeature	Epicanthus	A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus.	UMLS:C0678230	hp.json	Epicanthal folds|Epicanthic folds|Prominent eye folds|Epicanthal fold|Palpebronasal fold|Plica palpebronasalis|Eye folds	http://purl.obolibrary.org/obo/HP_0000286		hposlim_core
HP:0000288	biolink:PhenotypicFeature	Abnormality of the philtrum	An abnormality of the philtrum.	UMLS:C1857045	hp.json	Abnormality of the infranasal depression|Abnormality of the paralabial region|Abnormal philtrum	http://purl.obolibrary.org/obo/HP_0000288		hposlim_core
HP:0000287	biolink:PhenotypicFeature	Increased facial adipose tissue	An increased amount of subcutaneous fat tissue in the face.	UMLS:C4025868|UMLS:C4280650|UMLS:C4280649	hp.json	Hyperplasia of facial adipose tissue|Facial fat hyperplasia|Facial fat hypertrophy|Increased amount of facial adipose tissue|Increased amount of facial fat|Hypertrophy of facial adipose tissue|Increased volume of facial adipose tissue	http://purl.obolibrary.org/obo/HP_0000287		
HP:0000289	biolink:PhenotypicFeature	Broad philtrum	Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations above the mean, or alternatively, an apparently increased distance between the ridges of the philtrum.	UMLS:C1854111	hp.json	Increased transverse dimension of philtrum|Increased breadth of philtrum|Wide philtrum|Increased horizontal dimension of philtrum|Increased width of philtrum	http://purl.obolibrary.org/obo/HP_0000289		hposlim_core
UBERON:0007606	biolink:AnatomicalEntity	ciliated stratified columnar epithelium		FMA:67521	hp.json		http://purl.obolibrary.org/obo/UBERON_0007606		
HP:0000280	biolink:PhenotypicFeature	Coarse facial features	Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues.	UMLS:C4072825|UMLS:C1845847	hp.json	Coarse facies|Coarse facial appearance|Coarse face|Thickened facial skin with coarse facial features|Rounded and heavy facial features|Coarse facial features	http://purl.obolibrary.org/obo/HP_0000280		hposlim_core
HP:0000282	biolink:PhenotypicFeature	Facial edema		UMLS:C0542571|SNOMEDCT_US:445088006	hp.json	Facial oedema|Facial puffiness|Facial swelling	http://purl.obolibrary.org/obo/HP_0000282		
UBERON:0007602	biolink:AnatomicalEntity	stratified columnar epithelium	Stratified columnar epithelia is a rare type of epithelial tissue composed of column shaped cells arranged in multiple layers. Stratified columnar epithelia are found in the ocular conjunctiva of the eye, in parts of the pharynx and anus, the female's uterus, the male urethra and vas deferens. Also found in intralobular ducts in salivary glands.[WP].	FMA:45564|UMLS:C0836132|NCIT:C33620	hp.json	epithelium stratificatum columnare	http://purl.obolibrary.org/obo/UBERON_0007602		
UBERON:0007601	biolink:AnatomicalEntity	ciliated epithelium	Epithelium bearing vibratile cilia on the free surface.		hp.json		http://purl.obolibrary.org/obo/UBERON_0007601		
HP:0000284	biolink:PhenotypicFeature	obsolete Abnormality of the ocular region			hp.json		http://purl.obolibrary.org/obo/HP_0000284		
HP:0000283	biolink:PhenotypicFeature	Broad face	Bizygomatic (upper face) and bigonial (lower face) width greater than 2 standard deviations above the mean (objective); or an apparent increase in the width of the face (subjective).	UMLS:C1859680	hp.json	Horizontal hyperplasia of face|Wide facies|Increased width of face|Increased transverse dimension of face|Horizontal excess of face|Broad face|Wide face|Transverse hyperplasia of face|Increased breadth of face|Transverse excess of face|Increased horizontal dimension of face|Broad facies	http://purl.obolibrary.org/obo/HP_0000283		hposlim_core
HP:0012242	biolink:PhenotypicFeature	Superior rectus atrophy	Atrophy of the superior rectus, the extraocular muscle whose primary function is to elevate the globe.	UMLS:C1851108	hp.json	Rectus superior atrophy	http://purl.obolibrary.org/obo/HP_0012242		
HP:0012243	biolink:PhenotypicFeature	Abnormal reproductive system morphology	A structural or developmental anomaly of any of the tissues involved in the genital system.	UMLS:C4021096	hp.json	Abnormal genital system morphology	http://purl.obolibrary.org/obo/HP_0012243		
HP:0012244	biolink:PhenotypicFeature	Abnormal sex determination	Anomaly of primary or secondary sexual development or characteristics.	UMLS:C4022996	hp.json		http://purl.obolibrary.org/obo/HP_0012244		
HP:0012245	biolink:PhenotypicFeature	Sex reversal	Development of the reproductive system is inconsistent with the chromosomal sex.	UMLS:C4022995	hp.json		http://purl.obolibrary.org/obo/HP_0012245		
HP:0012246	biolink:PhenotypicFeature	Oculomotor nerve palsy	Reduced ability to control the movement of the eye associated with damage to the third cranial nerve (the oculomotor nerve).	UMLS:C0028866|SNOMEDCT_US:388980004|MSH:D015840	hp.json	Oculomotor neuropathy	http://purl.obolibrary.org/obo/HP_0012246		
HP:0012247	biolink:PhenotypicFeature	Specific anosmia	Anosmia for one particular odor.	UMLS:C4022994	hp.json		http://purl.obolibrary.org/obo/HP_0012247		
HP:0012248	biolink:PhenotypicFeature	Prolonged PR interval	Increased time for the PR interval (beginning of the P wave to the beginning of the QRS complex).	UMLS:C0600125|SNOMEDCT_US:164947007	hp.json	Electrocardiographic long PR interval|Lengthened PR interval on EKG	http://purl.obolibrary.org/obo/HP_0012248		
HP:0012249	biolink:PhenotypicFeature	Abnormal ST segment	An electrocardiographic anomaly of the ST segment, which is the segment that connects the QRS complex and the T wave. The ST segment normally has a duration of 80 to 120 ms, is flat and at the same level (isoelectric) as the PR and TP segment.	UMLS:C4022993	hp.json		http://purl.obolibrary.org/obo/HP_0012249		
GO:0005753	biolink:CellularComponent	mitochondrial proton-transporting ATP synthase complex	A proton-transporting ATP synthase complex found in the mitochondrial membrane.		hp.json	mitochondrial respiratory chain complex V	http://purl.obolibrary.org/obo/GO_0005753		
HP:0012240	biolink:PhenotypicFeature	Increased intramyocellular lipid droplets	An abnormal increase in intracellular lipid droplets In a muscle. The number and size of these drops can increase with somd disorders of lipid metabolism affecting muscle. See PMID 20691590 for histological images.	UMLS:C4020730	hp.json	Increased muscle lipid droplets	http://purl.obolibrary.org/obo/HP_0012240		
HP:0012241	biolink:PhenotypicFeature	Levator palpebrae superioris atrophy	Atrophy of the levator palpebrae superioris, the extraocular muscle that elevates the superior eyelid.	UMLS:C1851107	hp.json		http://purl.obolibrary.org/obo/HP_0012241		
HP:0000253	biolink:PhenotypicFeature	Progressive microcephaly	Progressive microcephaly is diagnosed when the head circumference falls progressively behind age- and gender-dependent norms.	UMLS:C1850456	hp.json	Progressively abnormally small skull|Microcephaly, progressive|Progressively abnormally small cranium|Microcephaly, postnatal, progressive	http://purl.obolibrary.org/obo/HP_0000253		
HP:0000252	biolink:PhenotypicFeature	Microcephaly	Head circumference below 2 standard deviations below the mean for age and gender.	SNOMEDCT_US:271611007|Fyler:4310|UMLS:C4551563	hp.json	Decreased size of cranium|Abnormally small cranium|small calvarium|Reduced head circumference|small cranium|Small head|Small skull|Decreased size of head|Abnormally small head|Abnormally small skull|Decreased size of skull|Small head circumference|Decreased circumference of cranium	http://purl.obolibrary.org/obo/HP_0000252		hposlim_core
HP:0000255	biolink:PhenotypicFeature	Acute sinusitis	An acute form of sinusitis.	UMLS:C0149512|SNOMEDCT_US:15805002	hp.json		http://purl.obolibrary.org/obo/HP_0000255		
HP:0000256	biolink:PhenotypicFeature	Macrocephaly	Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium.	UMLS:C4280664|UMLS:C4280663|Fyler:4335|UMLS:C4083076|UMLS:C4255213	hp.json	Big calvaria|Big head|Increased size of skull|Large head|Megacephaly|Large head circumference|Big skull|Increased size of cranium|Large calvaria|Increased size of head|Large skull|Big cranium|Macrocrania|Large cranium|Macrocephalus	http://purl.obolibrary.org/obo/HP_0000256		hposlim_core
HP:0000250	biolink:PhenotypicFeature	Dense calvaria	An abnormal increase of density of the bones making up the calvaria.	UMLS:C1854834	hp.json	Dense skull cap	http://purl.obolibrary.org/obo/HP_0000250		
HP:0012231	biolink:PhenotypicFeature	Exudative retinal detachment	A type of retinal detachment arising from damage to the outer blood-retinal barrier that allows fluid to access the subretinal space and separate the neurosensory retina from the retinal pigment epithelium.	SNOMEDCT_US:38599001|UMLS:C0154822	hp.json	Serous retinal detachment	http://purl.obolibrary.org/obo/HP_0012231		
HP:0012232	biolink:PhenotypicFeature	Shortened QT interval	Decreased time between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).	UMLS:C0151879|SNOMEDCT_US:77867006	hp.json		http://purl.obolibrary.org/obo/HP_0012232		
GO:0003105	biolink:NamedThing	negative regulation of glomerular filtration			hp.json		http://purl.obolibrary.org/obo/GO_0003105		
HP:0012233	biolink:PhenotypicFeature	Intramuscular hematoma	Blood clot formed within muscle tissue following leakage of blood into the tissue.	SNOMEDCT_US:262969000|UMLS:C0240412	hp.json	Intramuscular haematoma|Intramuscular hematomas|Intramuscular hemorrhage|IM hematoma|Intramuscular haemorrhage	http://purl.obolibrary.org/obo/HP_0012233		
HP:0012234	biolink:PhenotypicFeature	Agranulocytosis	Marked decrease in the number of granulocytes.	UMLS:C0702094	hp.json		http://purl.obolibrary.org/obo/HP_0012234		
GO:0005765	biolink:CellularComponent	lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.		hp.json	lysosome membrane	http://purl.obolibrary.org/obo/GO_0005765		
HP:0012235	biolink:PhenotypicFeature	Drug-induced agranulocytosis	A type of agranulocytosis related to ingestion of a specific medication.	UMLS:C0272178|SNOMEDCT_US:47318007	hp.json		http://purl.obolibrary.org/obo/HP_0012235		
HP:0012236	biolink:PhenotypicFeature	Elevated sweat chloride	An increased concentration of chloride in the sweat.	UMLS:C1856646	hp.json	Elevated sweat chloride|Elevated sweat Cl-|Elevated sweat Cl	http://purl.obolibrary.org/obo/HP_0012236		
GO:0005766	biolink:CellularComponent	primary lysosome	A lysosome before it has fused with a vesicle or vacuole.	NIF_Subcellular:sao1140587416	hp.json		http://purl.obolibrary.org/obo/GO_0005766		
HP:0012237	biolink:PhenotypicFeature	Urocanic aciduria	An increased concentration of urocanic acid in the urine.	UMLS:C0268514|MSH:C536479|SNOMEDCT_US:60952007	hp.json	High urine urocanic acid levels	http://purl.obolibrary.org/obo/HP_0012237		
GO:0003104	biolink:NamedThing	positive regulation of glomerular filtration			hp.json		http://purl.obolibrary.org/obo/GO_0003104		
HP:0012238	biolink:PhenotypicFeature	Increased circulating chylomicron concentration	Increased plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins.	UMLS:C1535978	hp.json	Increased chylomicrons|Increased circulating chylomicron levels|Hyperchylomicronemia	http://purl.obolibrary.org/obo/HP_0012238		
GO:0005764	biolink:CellularComponent	lysosome	A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.	NIF_Subcellular:sao585356902|Wikipedia:Lysosome	hp.json		http://purl.obolibrary.org/obo/GO_0005764		goslim_plant|goslim_chembl|goslim_generic
CHEBI:42485	biolink:ChemicalSubstance	formyl group		PDBeChem:FOR	hp.json	methanoyl|formyl|Fo|-CH(O)|aldehyde group|FORMYL GROUP|-CHO|carbaldehyde|H-CO-	http://purl.obolibrary.org/obo/CHEBI_42485		3_STAR
GO:0030705	biolink:BiologicalProcess	cytoskeleton-dependent intracellular transport	The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0030705		goslim_drosophila|goslim_chembl
HP:0012230	biolink:PhenotypicFeature	Rhegmatogenous retinal detachment	A type of retinal detachment associated with a retinal tear, that is, with a break in the retina that allows fluid to pass from the vitreous space into the subretinal space between the sensory retina and the retinal pigment epithelium.	SNOMEDCT_US:19620000|UMLS:C0271055	hp.json		http://purl.obolibrary.org/obo/HP_0012230		
HP:0000264	biolink:PhenotypicFeature	Abnormality of the mastoid	An abnormality of the mastoid process, which is the conical prominence projecting from the undersurface of the mastoid portion of the temporal bone.	UMLS:C4025872	hp.json	Abnormality of mastoid process of temporal bone	http://purl.obolibrary.org/obo/HP_0000264		hposlim_core
HP:0000263	biolink:PhenotypicFeature	Oxycephaly	Oxycephaly (from Greek oxus, sharp, and kephalos, head) refers to a conical or pointed shape of the skull.	MSH:D003398	hp.json	Acrocephaly	http://purl.obolibrary.org/obo/HP_0000263		
HP:0000265	biolink:PhenotypicFeature	Mastoiditis		UMLS:C0024904|MSH:D008417|SNOMEDCT_US:52404001	hp.json		http://purl.obolibrary.org/obo/HP_0000265		
HP:0000268	biolink:PhenotypicFeature	Dolichocephaly	An abnormality of skull shape characterized by a increased anterior-posterior diameter, i.e., an increased antero-posterior dimension of the skull. Cephalic index less than 76%. Alternatively, an apparently increased antero-posterior length of the head compared to width. Often due to premature closure of the sagittal suture.	SNOMEDCT_US:72239002|UMLS:C4280656|UMLS:C4280655|UMLS:C4280654|UMLS:C4280653|UMLS:C0221358	hp.json	Narrow skull shape|Narrow head shape|Narrow cranium shape|Turridolichocephaly|Long, narrow head|Large dolichocephalic skull|Tall and narrow skull	http://purl.obolibrary.org/obo/HP_0000268		hposlim_core
HP:0000267	biolink:PhenotypicFeature	Cranial asymmetry	Asymmetry of the bones of the skull.	UMLS:C1860245|UMLS:C4280657|UMLS:C4280258|UMLS:C4280662|UMLS:C4280661|UMLS:C4280660|UMLS:C4280659|UMLS:C4280658	hp.json	Abnormality of cranium shape|Uneven head shape|Malformation of cranium shape|Asymmetry of cranium|Malformation of head shape|Asymmetry of head|Abnormality of head shape|Abnormality of cranial vault shape|Cranial vault asymmetry|Malformation of cranial vault shape	http://purl.obolibrary.org/obo/HP_0000267		
HP:0000269	biolink:PhenotypicFeature	Prominent occiput	Increased convexity of the occiput (posterior part of the skull).	UMLS:C4280652|UMLS:C1853737	hp.json	Prominent back of the skull|Prominent posterior skull|Prominent posterior head|Protruding occiput|Prominent back of the head|Protruding back of the head|Prominent posterior cranium	http://purl.obolibrary.org/obo/HP_0000269		hposlim_core
HP:0012239	biolink:PhenotypicFeature	Atransferrinemia	Absence of transferrin, a protein that transports iron, in the blood.	UMLS:C0521802|MSH:C538259|SNOMEDCT_US:111571009	hp.json		http://purl.obolibrary.org/obo/HP_0012239		
HP:0000260	biolink:PhenotypicFeature	Wide anterior fontanel	Enlargement of the anterior fontanelle with respect to age-dependent norms.	UMLS:C1866134	hp.json	Wider-than-typical soft spot of skull|Large anterior fontanels|Wide anterior fontanelle|Large anterior fontanel|Large open anterior fontanelle|Large anterior fontanelle|Wide open anterior fontanelle|Large open anterior fontanel	http://purl.obolibrary.org/obo/HP_0000260		
HP:0000262	biolink:PhenotypicFeature	Turricephaly	Tall head relative to width and length.	SNOMEDCT_US:48069004|MSH:D003398|UMLS:C0030044	hp.json	Tower cranium shape|Tall shaped head|Tall shaped cranium|Tower skull shape|Turricephalus|Tall shaped skull	http://purl.obolibrary.org/obo/HP_0000262		hposlim_core
GO:1904037	biolink:BiologicalProcess	positive regulation of epithelial cell apoptotic process	Any process that activates or increases the frequency, rate or extent of epithelial cell apoptotic process.		hp.json	upregulation of epithelial cell apoptotic process|upregulation of epitheliocyte apoptotic process|up-regulation of epithelial cell apoptosis|up-regulation of epitheliocyte apoptosis|up regulation of epithelial cell apoptosis|up regulation of epitheliocyte apoptosis|positive regulation of epithelial cell apoptosis|positive regulation of epitheliocyte apoptosis|up-regulation of epithelial cell apoptotic process|up-regulation of epitheliocyte apoptotic process|upregulation of epithelial cell apoptosis|up regulation of epithelial cell apoptotic process|activation of epithelial cell apoptotic process|upregulation of epitheliocyte apoptosis|up regulation of epitheliocyte apoptotic process|activation of epithelial cell apoptosis|activation of epitheliocyte apoptotic process|activation of epitheliocyte apoptosis|positive regulation of epitheliocyte apoptotic process	http://purl.obolibrary.org/obo/GO_1904037		
GO:1904036	biolink:BiologicalProcess	negative regulation of epithelial cell apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of epithelial cell apoptotic process.		hp.json	down regulation of epitheliocyte apoptosis|down-regulation of epithelial cell apoptotic process|down-regulation of epitheliocyte apoptotic process|negative regulation of epitheliocyte apoptotic process|downregulation of epithelial cell apoptosis|downregulation of epitheliocyte apoptosis|down regulation of epithelial cell apoptotic process|down regulation of epitheliocyte apoptotic process|inhibition of epithelial cell apoptosis|downregulation of epithelial cell apoptotic process|inhibition of epithelial cell apoptotic process|downregulation of epitheliocyte apoptotic process|inhibition of epitheliocyte apoptosis|inhibition of epitheliocyte apoptotic process|down-regulation of epithelial cell apoptosis|negative regulation of epithelial cell apoptosis|negative regulation of epitheliocyte apoptosis|down-regulation of epitheliocyte apoptosis|down regulation of epithelial cell apoptosis	http://purl.obolibrary.org/obo/GO_1904036		
GO:1904064	biolink:BiologicalProcess	positive regulation of cation transmembrane transport	Any process that activates or increases the frequency, rate or extent of cation transmembrane transport.		hp.json	upregulation of cation transmembrane transport|up regulation of cation transmembrane transport|activation of cation transmembrane transport|up-regulation of cation transmembrane transport	http://purl.obolibrary.org/obo/GO_1904064		
GO:1904063	biolink:BiologicalProcess	negative regulation of cation transmembrane transport	Any process that stops, prevents or reduces the frequency, rate or extent of cation transmembrane transport.		hp.json	inhibition of cation transmembrane transport|down-regulation of cation transmembrane transport|downregulation of cation transmembrane transport|down regulation of cation transmembrane transport	http://purl.obolibrary.org/obo/GO_1904063		
GO:1904062	biolink:BiologicalProcess	regulation of cation transmembrane transport	Any process that modulates the frequency, rate or extent of cation transmembrane transport.		hp.json		http://purl.obolibrary.org/obo/GO_1904062		
UBERON:0019293	biolink:AnatomicalEntity	white matter of pontine tegmentum		FMA:83942|HBA:265505486|BIRNLEX:1069	hp.json	white matter of pontile tegmentum|white substance of pontile tegmentum|pontine white matter tracts|substantia alba tegmenti pontis|predominantly white regional part of pontine tegmentum	http://purl.obolibrary.org/obo/UBERON_0019293		
UBERON:0019294	biolink:AnatomicalEntity	commissure of telencephalon		HBA:9220	hp.json	telencephalic commissures	http://purl.obolibrary.org/obo/UBERON_0019294		
UBERON:0019291	biolink:AnatomicalEntity	white matter of metencephalon		HBA:9287|FMA:83939	hp.json		http://purl.obolibrary.org/obo/UBERON_0019291		
UBERON:0019292	biolink:AnatomicalEntity	white matter of pons		FMA:83940	hp.json		http://purl.obolibrary.org/obo/UBERON_0019292		
GO:1904075	biolink:BiologicalProcess	positive regulation of trophectodermal cell proliferation	Any process that activates or increases the frequency, rate or extent of trophectodermal cell proliferation.		hp.json	activation of trophectoderm cell proliferation|upregulation of trophectodermal cell proliferation|upregulation of trophectoderm cell proliferation|up regulation of trophectodermal cell proliferation|positive regulation of trophectoderm cell proliferation|up-regulation of trophectodermal cell proliferation|activation of trophectodermal cell proliferation|up regulation of trophectoderm cell proliferation|up-regulation of trophectoderm cell proliferation	http://purl.obolibrary.org/obo/GO_1904075		
GO:1904074	biolink:BiologicalProcess	negative regulation of trophectodermal cell proliferation	Any process that stops, prevents or reduces the frequency, rate or extent of trophectodermal cell proliferation.		hp.json	down-regulation of trophectodermal cell proliferation|down regulation of trophectoderm cell proliferation|inhibition of trophectoderm cell proliferation|down-regulation of trophectoderm cell proliferation|negative regulation of trophectoderm cell proliferation|downregulation of trophectodermal cell proliferation|down regulation of trophectodermal cell proliferation|inhibition of trophectodermal cell proliferation|downregulation of trophectoderm cell proliferation	http://purl.obolibrary.org/obo/GO_1904074		
GO:1904073	biolink:BiologicalProcess	regulation of trophectodermal cell proliferation	Any process that modulates the frequency, rate or extent of trophectodermal cell proliferation.		hp.json	regulation of trophectoderm cell proliferation	http://purl.obolibrary.org/obo/GO_1904073		
HP:0002616	biolink:PhenotypicFeature	Aortic root aneurysm	An abnormal localized widening (dilatation) of the aortic root.	UMLS:C0238669|SNOMEDCT_US:251036003	hp.json	Increased aortic root diameter|Bulge in wall of root of large artery that carries blood away from heart|Aortic root dilatation	http://purl.obolibrary.org/obo/HP_0002616		
HP:0002617	biolink:PhenotypicFeature	Vascular dilatation	Abnormal outpouching or sac-like dilatation in the wall of an atery, vein or the heart.	SNOMEDCT_US:85659009|MSH:D000783|UMLS:C0002940|UMLS:C4020848|SNOMEDCT_US:432119003|Fyler:2399	hp.json	Aneurysms|Aneurysmal dilatation|Aneurysm|Wider than typical opening or gap|Aneurysmal disease	http://purl.obolibrary.org/obo/HP_0002617		
HP:0002614	biolink:PhenotypicFeature	Hepatic periportal necrosis	A type of hepatic necrosis that is concentrated around the necrosis of hepatocytes localized around the intrahepatic branch of portal vein.	UMLS:C0546389	hp.json		http://purl.obolibrary.org/obo/HP_0002614		
HP:0002615	biolink:PhenotypicFeature	Hypotension	Low Blood Pressure, vascular hypotension.	SNOMEDCT_US:45007003|MSH:D007022|UMLS:C0020649	hp.json	Low blood pressure|Arterial hypotension	http://purl.obolibrary.org/obo/HP_0002615		
HP:0002619	biolink:PhenotypicFeature	Varicose veins	Enlarged and tortuous veins.	MSH:D014648|SNOMEDCT_US:12856003|SNOMEDCT_US:128060009|UMLS:C0042345|SNOMEDCT_US:399989005	hp.json		http://purl.obolibrary.org/obo/HP_0002619		
HP:0002612	biolink:PhenotypicFeature	Congenital hepatic fibrosis	The presence of fibrosis of that part of the liver with congenital onset.	MSH:C562378|SNOMEDCT_US:79607001|UMLS:C0009714	hp.json	Excessive buildup of connective tissue and scarring of liver at birth|Congenital liver fibrosis	http://purl.obolibrary.org/obo/HP_0002612		
HP:0002613	biolink:PhenotypicFeature	Biliary cirrhosis	Progressive destruction of the small-to-medium bile ducts of the intrahepatic biliary tree, which leads to progressive cholestasis and often end-stage liver disease.	SNOMEDCT_US:1761006|SNOMEDCT_US:31712002|MSH:D008105|UMLS:C0023892|UMLS:C0008312	hp.json	Primary biliary cirrhosis	http://purl.obolibrary.org/obo/HP_0002613		
HP:0002611	biolink:PhenotypicFeature	Cholestatic liver disease		UMLS:C0860204	hp.json		http://purl.obolibrary.org/obo/HP_0002611		
HP:0002627	biolink:PhenotypicFeature	Right aortic arch with mirror image branching	The aortic arch crosses the right mainstem bronchus and not the left mainstem bronchus, but does not result in the creation of a vascular ring. The first branch is the left brachiocephalic artery which divides into the left carotid artery and left subclavian artery, the second branch is the right carotid artery, the third branch is the right subclavian artery.	UMLS:C4025695	hp.json		http://purl.obolibrary.org/obo/HP_0002627		
HP:0002625	biolink:PhenotypicFeature	Deep venous thrombosis	Formation of a blot clot in a deep vein. The clot often blocks blood flow, causing swelling and pain. The deep veins of the leg are most often affected.	SNOMEDCT_US:128053003|UMLS:C0149871|MSH:D020246	hp.json	Multiple deep venous thrombosis|Blood clot in a deep vein|Deep vein thrombosis	http://purl.obolibrary.org/obo/HP_0002625		
HP:0002626	biolink:PhenotypicFeature	Venous varicosities of celiac and mesenteric vessels	Elongated and tortuous mesenteric veins, which comprise the inferior mesenteric vein and the superior mesenteric vein.	UMLS:C1857692	hp.json	Venous varicosities of coeliac and mesenteric vessels	http://purl.obolibrary.org/obo/HP_0002626		
HP:0002629	biolink:PhenotypicFeature	Gastrointestinal arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the gastrointestinal tract.	UMLS:C0744321	hp.json	GI arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0002629		
GO:1904099	biolink:BiologicalProcess	negative regulation of protein O-linked glycosylation	Any process that stops, prevents or reduces the frequency, rate or extent of protein O-linked glycosylation.		hp.json	inhibition of protein O-linked glycosylation|down-regulation of protein O-linked glycosylation|negative regulation of protein amino acid O-linked glycosylation|down-regulation of protein amino acid O-linked glycosylation|down regulation of protein amino acid O-linked glycosylation|downregulation of protein O-linked glycosylation|downregulation of protein amino acid O-linked glycosylation|inhibition of protein amino acid O-linked glycosylation|down regulation of protein O-linked glycosylation	http://purl.obolibrary.org/obo/GO_1904099		
GO:1904098	biolink:BiologicalProcess	regulation of protein O-linked glycosylation	Any process that modulates the frequency, rate or extent of protein O-linked glycosylation.		hp.json	regulation of protein amino acid O-linked glycosylation	http://purl.obolibrary.org/obo/GO_1904098		
HP:0002623	biolink:PhenotypicFeature	Overriding aorta	An overriding aorta is a congenital heart defect where the aorta is positioned directly over a ventricular septal defect, instead of over the left ventricle. The result is that the aorta receives some blood from the right ventricle, which reduces the amount of oxygen in the blood. It is one of the four conditions of the Tetralogy of Fallot. The aortic root can be displaced toward the front (anteriorly) or directly above the septal defect, but it is always abnormally located to the right of the root of the pulmonary artery. The degree of override is quite variable, with 5-95% of the valve being connected to the right ventricle.	SNOMEDCT_US:63934006|UMLS:C0265886|UMLS:C0011818|Fyler:1432	hp.json	Overriding aortic valve|Dextroposition of aorta	http://purl.obolibrary.org/obo/HP_0002623		
HP:0002624	biolink:PhenotypicFeature	Abnormal venous morphology	An anomaly of vein.	UMLS:C0241665	hp.json	Abnormal vein|Venous abnormality	http://purl.obolibrary.org/obo/HP_0002624		
HP:0002621	biolink:PhenotypicFeature	Atherosclerosis	A condition characterized by patchy atheromas or atherosclerotic plaques which develop in the walls of medium-sized and large arteries and can lead to arterial stenosis with reduced or blocked blood flow.	UMLS:C4280569|SNOMEDCT_US:38716007|UMLS:C0004153|MSH:D050197	hp.json	Plaque build-up in arteries|Atherosclerotic cardiovascular disease|Narrowing and hardening of arteries	http://purl.obolibrary.org/obo/HP_0002621		
HP:0002622	biolink:PhenotypicFeature	obsolete Dissecting aortic dilatation			hp.json		http://purl.obolibrary.org/obo/HP_0002622		
GO:0003298	biolink:BiologicalProcess	physiological muscle hypertrophy	The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.		hp.json		http://purl.obolibrary.org/obo/GO_0003298		
GO:0003292	biolink:BiologicalProcess	cardiac septum cell differentiation	The process in which an endocardial cushion cell becomes a cell of a cardiac septum.		hp.json		http://purl.obolibrary.org/obo/GO_0003292		
HP:0002605	biolink:PhenotypicFeature	Hepatic necrosis	The presence of cell death (necrosis) affecting the liver.	UMLS:C0151798|SNOMEDCT_US:87248009	hp.json		http://purl.obolibrary.org/obo/HP_0002605		
HP:0002604	biolink:PhenotypicFeature	Gastrointestinal telangiectasia	Telangiectasia affecting the gastrointestinal tract.	UMLS:C1619711	hp.json	Small, enlarged blood vessels near skin|GI telangiectasia	http://purl.obolibrary.org/obo/HP_0002604		
HGNC:3686	biolink:Gene	FGF8 (human)	A protein coding gene FGF8 in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3686		
HP:0002607	biolink:PhenotypicFeature	Bowel incontinence	Involuntary fecal soiling in adults and children who have usually already been toilet trained.	SNOMEDCT_US:72042002|UMLS:C0015732|MSH:D005242	hp.json	Faecal incontinence|Anal incontinence|Loss of bowel control|Fecal incontinence	http://purl.obolibrary.org/obo/HP_0002607		
HP:0002608	biolink:PhenotypicFeature	Celiac disease	Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. Clinical manifestations of CD are highly variable and include both gastrointestinal and non-gastrointestinal features. The hallmark of CD is an immune-mediated enteropathy. This term is included because the occurence of CD is seen as a feature of a number of other diseases.	MSH:D002446|UMLS:C0007570|SNOMEDCT_US:396331005	hp.json	Celiac sprue|Coeliac disease|Celiac disease|Coeliac sprue	http://purl.obolibrary.org/obo/HP_0002608		
HP:0002601	biolink:PhenotypicFeature	Paresis of extensor muscles of the big toe		UMLS:C4025696	hp.json		http://purl.obolibrary.org/obo/HP_0002601		
HP:0002600	biolink:PhenotypicFeature	Hyporeflexia of lower limbs	Reduced intensity of muscle tendon reflexes in the lower limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping.	UMLS:C1834696	hp.json	Hyporeflexia in lower limbs|Hyporeflexia/areflexia in lower limbs|Hyporeflexia, lower limbs|Hyporeflexia of the lower limbs	http://purl.obolibrary.org/obo/HP_0002600		
UBERON:0019231	biolink:AnatomicalEntity	manual digit 1 or 5			hp.json	lateral finger|lateral manual digit|outer manual digit|outermost manual digit	http://purl.obolibrary.org/obo/UBERON_0019231		
UBERON:0019232	biolink:AnatomicalEntity	manual digit 2, 3 or 4			hp.json	mesoxaxial finger|medial manual digit|mesoaxial manual digit	http://purl.obolibrary.org/obo/UBERON_0019232		pheno_slim
UBERON:0034873	biolink:AnatomicalEntity	bodily gas	Any substance in the body or expelled from the body that is in a gaseous state.	FMA:84580	hp.json	portion of gas in anatomical space|gas in anatomical space	http://purl.obolibrary.org/obo/UBERON_0034873		
UBERON:0034874	biolink:AnatomicalEntity	air in respiratory system	Any portion of gas located in a part of the respiratory system that is composed primarily of air.	FMA:84581	hp.json	respiratory air|respiratory system air	http://purl.obolibrary.org/obo/UBERON_0034874		
UBERON:0034875	biolink:AnatomicalEntity	future pituitary gland		EHDAA2:0001472|EMAPA:32796	hp.json	pituitary primordium	http://purl.obolibrary.org/obo/UBERON_0034875		
UBERON:0007257	biolink:AnatomicalEntity	intervertebral disk of sacral vertebra	An intervertebral disk that is part of a sacral region of vertebral column. A sacral intervertebral disk connects at least one sacral vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra.	FMA:268676|EMAPA:19575	hp.json	intervertebral disc of sacral region	http://purl.obolibrary.org/obo/UBERON_0007257		
UBERON:0010899	biolink:AnatomicalEntity	synchronous hermaphroditic organism	Hermaphroditic organism that produces both male and female gametes at the same time.	BILA:0000046|CARO:0000046|TADS:0000609|HAO:0000046|AAO:0010046	hp.json	simultaneous hermaphroditic organism|serially hermaphroditic organism	http://purl.obolibrary.org/obo/UBERON_0010899		
UBERON:0007255	biolink:AnatomicalEntity	intervertebral disk of lumbar vertebra	An intervertebral disk that is part of a lumbar region of vertebral column. A lumbar intervertebral disk connects at least one lumbar vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a sacral vertebra.	FMA:13894|EMAPA:19468	hp.json	intervertebral disc of lumbar region	http://purl.obolibrary.org/obo/UBERON_0007255		
UBERON:0007254	biolink:AnatomicalEntity	intervertebral disk of thoracic vertebra	An intervertebral disk that is part of a thoracic region of vertebral column. A thoracic intervertebral disk connects at least one thoracic vertebra, either to another thoracic vertebra, or at one point on the vertebral colummn, to a lumbar vertebra.	FMA:10455|EMAPA:19489	hp.json	intervertebral disc of thoracic region	http://purl.obolibrary.org/obo/UBERON_0007254		
GO:0042886	biolink:BiologicalProcess	amide transport	The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0042886		goslim_pir
UBERON:0007252	biolink:AnatomicalEntity	intervertebral disk of cervical vertebra	An intervertebral disk that is part of a cervical region of vertebral column. A cervical intervertebral disk connects at least one cervical vertebra, either to another cervical vertebra, or at one point on the vertebral colummn, to a thoracic vertebra.	FMA:13895|EMAPA:19415	hp.json	intervertebral disc of cervical region|cervical intervertebral disc	http://purl.obolibrary.org/obo/UBERON_0007252		
UBERON:0007250	biolink:AnatomicalEntity	lingual tonsil	The lymph tissue on the floor of the oropharyngeal passage, near the root of the tongue.	UMLS:C0229871|NCIT:C32988|MA:0000773|FMA:54836	hp.json	lingual tonsillar tissue|tonsilla lingualis	http://purl.obolibrary.org/obo/UBERON_0007250		pheno_slim
CHEBI:6495	biolink:ChemicalSubstance	lipoprotein	A clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.	KEGG:C01834	hp.json	Lipoprotein|lipoprotein particle|lipoproteins	http://purl.obolibrary.org/obo/CHEBI_6495		3_STAR
PR:P02771	biolink:Protein	alpha-fetoprotein (human)	An alpha-fetoprotein that is encoded in the genome of human.	UniProtKB:P02771	hp.json	HPAFP|alpha-1-fetoprotein (human)|alpha-fetoglobulin (human)|AFP|hAFP	http://purl.obolibrary.org/obo/PR_P02771		
GO:0005902	biolink:NamedThing	microvillus			hp.json		http://purl.obolibrary.org/obo/GO_0005902		
UBERON:0019222	biolink:AnatomicalEntity	digit 2, 3 or 4	Any of the three medial digits in a five-digit autopod, or their phylogenetic equivalent.		hp.json	mesoaxial digit|medial digit	http://purl.obolibrary.org/obo/UBERON_0019222		pheno_slim
UBERON:0019221	biolink:AnatomicalEntity	digit 1 or 5	Either of the outermost digits in a five-digit autopod, or their phylogenetic equivalent.		hp.json	outermost digit|outer digit|lateral digit	http://purl.obolibrary.org/obo/UBERON_0019221		
CHEBI:30413	biolink:ChemicalSubstance	heme	A heme is any tetrapyrrolic chelate of iron.	KEGG:C00032|COMe:MOL000025|DrugBank:DB03014	hp.json	heme|hemos|haeme|haem|hem|Haem|haem|hemes|heme|heme	http://purl.obolibrary.org/obo/CHEBI_30413		3_STAR
PR:P02768	biolink:Protein	albumin (human)	An albumin that is encoded in the genome of human.	UniProtKB:P02768	hp.json	PRO2675|hALB|serum albumin (human)|PRO2044|PRO1708|PRO2619|PRO0903|UNQ696/PRO1341|ALB|GIG42|GIG20	http://purl.obolibrary.org/obo/PR_P02768		
UBERON:0010890	biolink:AnatomicalEntity	pelvic complex muscle	Muscles of the pelvic girdle, hindlimb or pelvic fin.	AAO:0000218|FMA:9622|MA:0000663|EMAPA:32634	hp.json	pelvic girdle or hind limb muscle|pelvic girdle and hind limb muscles|pelvic girdle or posterior limb muscle|lower limb muscle|muscle of pelvic girdle and leg|pelvic girdle or posterior limb muscle|muscle of lower limb|pelvic girdle or hind limb muscle	http://purl.obolibrary.org/obo/UBERON_0010890		pheno_slim
UBERON:0010891	biolink:AnatomicalEntity	pectoral complex muscle	A muscle of a pectoral girdle, pectoral fin or anterior limb.	FMA:9621|AAO:0010687|EMAPA:32624|MA:0000615	hp.json	pectoral girdle and fore limb muscles|muscle of upper limb|muscle of pectoral girdle and wing|muscle of pectoral girdle and limb|upper limb muscle	http://purl.obolibrary.org/obo/UBERON_0010891		
UBERON:0010894	biolink:AnatomicalEntity	keratinous tooth			hp.json	horny denticle	http://purl.obolibrary.org/obo/UBERON_0010894		cyclostome_subset
UBERON:0010893	biolink:AnatomicalEntity	median external naris	Am unpaired external naris that lies in the midline of the head.		hp.json	nasohypophysial opening|median nostril|median anterior naris	http://purl.obolibrary.org/obo/UBERON_0010893		cyclostome_subset
UBERON:0034876	biolink:AnatomicalEntity	future neurohypophysis	The outgrowth of neuroectoderm located on the floor of the embryonic hypothalamus that gives rise to the neurohypophysis (posterior lobe) of the pituitary gland.	EMAPA:16647|EHDAA2:0004434	hp.json	neurohypophyseal bud|neurohypohysial region	http://purl.obolibrary.org/obo/UBERON_0034876		
UBERON:0010887	biolink:AnatomicalEntity	tragus	A small pointed eminence of the external ear, situated in front of the concha, and projecting backward over the meatus.	NCIT:C33801|FMA:60998|UMLS:C0229312	hp.json	tragal part of pinna	http://purl.obolibrary.org/obo/UBERON_0010887		pheno_slim
UBERON:0007245	biolink:AnatomicalEntity	nuclear complex of neuraxis	Gray matter of the central nervous system which is a collection of clustered nuclei.	FMA:256381|FMA:84059	hp.json	nuclear complex|neural nuclei|cluster of neural nuclei	http://purl.obolibrary.org/obo/UBERON_0007245		
UBERON:0010885	biolink:AnatomicalEntity	hindlimb cartilage element	A cartilaginous condensation that has the potential to develop into a hindlimb bone.	EMAPA:32632	hp.json	hindlimb cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010885		
UBERON:0034878	biolink:AnatomicalEntity	prechordal mesoderm	The area of axial mesoderm that develops into the prechordal plate.		hp.json	prechordal mesenchyme	http://purl.obolibrary.org/obo/UBERON_0034878		
CHEBI:17418	biolink:ChemicalSubstance	valeric acid	A straight-chain saturated fatty acid containing five carbon atoms.	LIPID_MAPS_instance:LMFA01010005|KEGG:C00803|Wikipedia:Valeric_acid|HMDB:HMDB0000892|PPDB:3130|PDBeChem:LEA|CAS:109-52-4|PMID:20507156|Gmelin:26714|CAS:109-52-4|DrugBank:DB02406|Beilstein:969454|CAS:109-52-4|KNApSAcK:C00001208|Reaxys:969454	hp.json	Pentanoic acid|Valerianic acid|Pentanoate|Valeric acid|n-Pentanoate|propylacetic acid|n-pentanoic acid|pentoic acid|PENTANOIC ACID|1-butanecarboxylic acid|pentanoic acid|CH3-[CH2]3-COOH|1-butanecarboxylic acid|Valerate|n-Valeric acid|Valeriansaeure|n-valeric acid|n-BuCOOH|valeric acid, normal	http://purl.obolibrary.org/obo/CHEBI_17418		3_STAR
UBERON:0010886	biolink:AnatomicalEntity	hindlimb pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a hindlimb bone.	EMAPA:32638	hp.json	hindlimb pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010886		
UBERON:0007243	biolink:AnatomicalEntity	tunica media of vein	A tunica media that is part of a vein.	EMAPA:36309|EV:0100033|SCTID:42049001|FMA:14354	hp.json	tunica media (venae)|venous media	http://purl.obolibrary.org/obo/UBERON_0007243		
UBERON:0007242	biolink:AnatomicalEntity	tunica intima of vein	A tunica intima that is part of a vein.	SCTID:2436009|EMAPA:36308|EV:0100032|FMA:14353	hp.json	tunica interna (intima)(venae)|venous intima	http://purl.obolibrary.org/obo/UBERON_0007242		
UBERON:0007241	biolink:AnatomicalEntity	tunica adventitia of vein	A tunica adventitia that is part of a vein.	EV:0100034|FMA:14355|SCTID:13202006|EMAPA:36310	hp.json	venous adventitia|tunica externa (adventitia)(venae)	http://purl.obolibrary.org/obo/UBERON_0007241		
UBERON:0007240	biolink:AnatomicalEntity	tunica adventitia of artery	A tunica adventitia that is part of a artery.	EV:0100030|FMA:14274|SCTID:113261001|EMAPA:36295	hp.json	arterial adventitia|tunica externa (adventitia)(arteriae)	http://purl.obolibrary.org/obo/UBERON_0007240		
CHEBI:30411	biolink:ChemicalSubstance	cobalamin	A cobalt-corrinoid hexaamide that is cobalamin with the oxidation state of the central cobalt atom unspecified.	PMID:15181872|COMe:MOL000036|PDBeChem:B12|PMID:11371572	hp.json	cobalamin|Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-cobamide|COBALAMIN	http://purl.obolibrary.org/obo/CHEBI_30411		3_STAR
UBERON:0007247	biolink:AnatomicalEntity	nucleus of superior olivary complex	Any of the nuclei that comprise the superior olivary complex (superior olive). This includes both the primary nuclei such as the lateral and medial nuclei, as well as periolivary nuclei.	FMA:72246|SCTID:369024009	hp.json	superior olivary complex nucleus	http://purl.obolibrary.org/obo/UBERON_0007247		grouping_class|pheno_slim
UBERON:0019210	biolink:AnatomicalEntity	pole of lens	A central point or region on the anterior or posterior surface of the lens.	FMA:58067	hp.json	lens pole|zone of lens|lens zone	http://purl.obolibrary.org/obo/UBERON_0019210		
UBERON:0010883	biolink:AnatomicalEntity	forelimb cartilage element	A cartilaginous condensation that has the potential to develop into a forelimb bone.	EMAPA:32626	hp.json	wing cartilaginous condensation|forelimb wing cartilaginous condensation	http://purl.obolibrary.org/obo/UBERON_0010883		grouping_class
UBERON:0010884	biolink:AnatomicalEntity	forelimb bone pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a forelimb bone.	EMAPA:32625	hp.json	wing bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010884		grouping_class
UBERON:0010881	biolink:AnatomicalEntity	limb cartilage element	A skeletal element that is part of a limb and composed of cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010881		
UBERON:0010882	biolink:AnatomicalEntity	limb bone pre-cartilage condensation	A skeletal element that is part of a limb and composed of pre-cartilage tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010882		
UBERON:0010879	biolink:AnatomicalEntity	tusk	A calcareous tooth that is elongated and protrudes from the mouth.		hp.json		http://purl.obolibrary.org/obo/UBERON_0010879		
UBERON:0009891	biolink:AnatomicalEntity	facial mesenchyme	Mesenchyme that is part of a developing face.	EMAPA:35337|FMA:302884	hp.json	face mesenchyme|mesenchyme of face	http://purl.obolibrary.org/obo/UBERON_0009891		
UBERON:0007239	biolink:AnatomicalEntity	tunica media of artery	A tunica media that is part of a artery.	EV:0100029|FMA:14273|UMLS:C1710627|EMAPA:36294|SCTID:84300001|NCIT:C49321	hp.json	arterial media|tunica media (arteriae)	http://purl.obolibrary.org/obo/UBERON_0007239		
UBERON:0007238	biolink:AnatomicalEntity	1st arch maxillary component		EMAPA:16388|EHDAA2:0000038|EHDAA:595|VHOG:0000511	hp.json		http://purl.obolibrary.org/obo/UBERON_0007238		
UBERON:0007237	biolink:AnatomicalEntity	1st arch mandibular component		EMAPA:16382|EHDAA:583|EHDAA2:0000031|VHOG:0000510	hp.json	ventral visceral arch 1|ventral mandibular arch|ventral pharyngeal arch 1	http://purl.obolibrary.org/obo/UBERON_0007237		
PR:P02788	biolink:Protein	lactotransferrin (human)	A lactotransferrin that is encoded in the genome of human.	UniProtKB:P02788	hp.json	talalactoferrin (human)|LTF|LF|hLTF|GIG12|lactoferrin (human)|growth-inhibiting protein 12 (human)	http://purl.obolibrary.org/obo/PR_P02788		
UBERON:0019200	biolink:AnatomicalEntity	skin of anterior chest	Zone of skin that is part of the anterior region of the chest.	FMA:10461	hp.json	skin of anterior part of thorax|ventral chest skin|skin of ventral chest|anterior chest skin	http://purl.obolibrary.org/obo/UBERON_0019200		pheno_slim
UBERON:0019206	biolink:AnatomicalEntity	tongue papilla epithelium		EMAPA:35869|MA:0003178	hp.json		http://purl.obolibrary.org/obo/UBERON_0019206		
UBERON:0019207	biolink:AnatomicalEntity	chorioretinal region	The part of the eye that consists of both the retina and the optic choroid.	SCTID:110701000	hp.json	choroid and retina|retinachoroidal region|chorioretina|retinachoroid	http://purl.obolibrary.org/obo/UBERON_0019207		pheno_slim
UBERON:0019204	biolink:AnatomicalEntity	skin epithelium	Any region of epithelium that is part of a skin region.	BTO:0004382	hp.json		http://purl.obolibrary.org/obo/UBERON_0019204		
CL:1000500	biolink:Cell	kidney interstitial cell		KUPO:0001013	hp.json		http://purl.obolibrary.org/obo/CL_1000500		
UBERON:0034898	biolink:AnatomicalEntity	alveolar ridge of premaxilla	The thickened ridge of bone that contains the tooth sockets on the premaxilla.	AAO:0000397	hp.json	pars dentalis of premaxilla	http://purl.obolibrary.org/obo/UBERON_0034898		
UBERON:0009887	biolink:AnatomicalEntity	interlobar vein	The interlobar veins are veins of the renal circulation which drain the renal lobes.	FMA:71631	hp.json	interlobar vein of kidney|interlobar veins of kidney|venae interlobares renis|set of interlobar veins of kidney|venae interlobares renis	http://purl.obolibrary.org/obo/UBERON_0009887		human_reference_atlas
UBERON:0007223	biolink:AnatomicalEntity	osseus cochlea	The osseous cochlea is the bony foundation that forms the small shell arrangement for the cochlear nerve.	EMAPA:35620|MA:0000239	hp.json		http://purl.obolibrary.org/obo/UBERON_0007223		pheno_slim
UBERON:0009889	biolink:AnatomicalEntity	secondary heart field	A specific region of the lateral mesoderm that will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).	XAO:0004186	hp.json	anterior/second heart field|second heart field|SHF|anterior heart field|anterior heart field	http://purl.obolibrary.org/obo/UBERON_0009889		
UBERON:0007220	biolink:AnatomicalEntity	late embryonic stage	An embryo stage that covers late steps of the embryogenesis with a fully formed embryo still developing before birth or egg hatching.	FBdv:00005333|FMA:63631|OGES:000023|MIAA:0000399|EV:0300011|MmusDv:0000031|EVM:2990031	hp.json	embryo late growth stage|fetal stage|embryo late (growth) stage|embryo late stage|fetus|fetus stage	http://purl.obolibrary.org/obo/UBERON_0007220		
UBERON:0009880	biolink:AnatomicalEntity	carpal skeleton	Subdivision of skeleton that consists of the endochondral elements distal to the anterior limb/fin zeugopodial skeletal elements which constitute the proximal region of the anterior autopod skeleton[PHENOSCAPE:ad].	VHOG:0001161|FMA:71335|AAO:0000201|MA:0000040|XAO:0003207|VSAO:0005023	hp.json	fore mesopodium|fore mesopodium skeleton|fore mesopodial skeleton|carpus|carpal bones|set of carpal bones|skeletal parts of fore mesopodium|skeleton of carpus|ossa carpi|ossa carpi|carpal bones set	http://purl.obolibrary.org/obo/UBERON_0009880		
UBERON:0009881	biolink:AnatomicalEntity	anterior lateral plate mesoderm		ZFA:0005041|TAO:0005041|EFO:0003704	hp.json	ALPM	http://purl.obolibrary.org/obo/UBERON_0009881		efo_slim
UBERON:0009882	biolink:AnatomicalEntity	anal column	One of a number of vertical folds, produced by an infolding of the mucous membrane and some of the muscular tissue in the upper half of the lumen of the anal canal[WP].	SCTID:245444007|NCIT:C32067|Wikipedia:Anal_columns|FMA:15713|UMLS:C0227428	hp.json	columnae anales|column of Morgagni	http://purl.obolibrary.org/obo/UBERON_0009882		
UBERON:0007228	biolink:AnatomicalEntity	vestibular nucleus	A cranial nucleus for the vestibular nerve. [WP,unvetted].	CALOHA:TS-2078|NCIT:C12821|FMA:54602|EMAPA:35923|MA:0001032|UMLS:C0042600|EV:0100254	hp.json	vestibular nucleus of eighth cranial nerve|vestibular VIII nucleus|vestibular nucleus of acoustic nerve	http://purl.obolibrary.org/obo/UBERON_0007228		human_reference_atlas
UBERON:0009883	biolink:AnatomicalEntity	medullary ray	A renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla.	FMA:74299|BTO:0001155|EMAPA:37906	hp.json	Ferrein's pyramid|kidney medullary ray|renal medullary ray	http://purl.obolibrary.org/obo/UBERON_0009883		pheno_slim|human_reference_atlas
UBERON:0009885	biolink:AnatomicalEntity	interlobar artery	An artery that supplies a renal lobe.	EMAPA:37091|FMA:71637	hp.json	interlobar artery of kidney|set of interlobar arteries of kidney|arteriae interlobares renis|arteriae interlobares renis|interlobar arteries of kidney|renal interlobar artery|kidney interlobar artery	http://purl.obolibrary.org/obo/UBERON_0009885		pheno_slim|human_reference_atlas
GO:1904000	biolink:BiologicalProcess	positive regulation of eating behavior	Any process that activates or increases the frequency, rate or extent of eating behavior.		hp.json	up regulation of eating behaviour|activation of eating behavior|up-regulation of eating behaviour|activation of eating behaviour|upregulation of eating behavior|upregulation of eating behaviour|up-regulation of eating behavior|positive regulation of eating behaviour|up regulation of eating behavior	http://purl.obolibrary.org/obo/GO_1904000		
UBERON:0007299	biolink:AnatomicalEntity	choroid plexus of tectal ventricle	A choroid plexus that is part of a cerebral aqueduct.	ZFA:0001445|TAO:0001445	hp.json	choroid plexus tectal ventricle|choroid plexus tectal ventricles	http://purl.obolibrary.org/obo/UBERON_0007299		
UBERON:0007297	biolink:AnatomicalEntity	presumptive pronephric mesoderm	A presumptive structure that has the potential to develop into a pronephric mesoderm.	TAO:0001070|EFO:0003619|ZFA:0001070	hp.json	nephron primordium	http://purl.obolibrary.org/obo/UBERON_0007297		efo_slim
UBERON:0019269	biolink:AnatomicalEntity	gray matter of diencephalon		FMA:83912	hp.json		http://purl.obolibrary.org/obo/UBERON_0019269		
UBERON:0019267	biolink:AnatomicalEntity	gray matter of midbrain		DHBA:10649|FMA:83913	hp.json		http://purl.obolibrary.org/obo/UBERON_0019267		human_reference_atlas
UBERON:0019264	biolink:AnatomicalEntity	gray matter of forebrain		DHBA:10157|FMA:268608	hp.json		http://purl.obolibrary.org/obo/UBERON_0019264		human_reference_atlas
UBERON:0019262	biolink:AnatomicalEntity	white matter of myelencephalon	A white matter that is part of the myelencephalon.	HBA:9298	hp.json	myelencephalic white matter	http://purl.obolibrary.org/obo/UBERON_0019262		
UBERON:0019263	biolink:AnatomicalEntity	gray matter of hindbrain		FMA:268630|DHBA:10654	hp.json	gray matter of the hindbrain	http://purl.obolibrary.org/obo/UBERON_0019263		human_reference_atlas
UBERON:0007282	biolink:AnatomicalEntity	presumptive segmental plate	A presumptive structure that has the potential to develop into a presomitic mesoderm.	ZFA:0000053|TAO:0000053|EFO:0003421	hp.json	presumptive segmental plates	http://purl.obolibrary.org/obo/UBERON_0007282		efo_slim
UBERON:0007281	biolink:AnatomicalEntity	presumptive midbrain hindbrain boundary	Embryonic structure that gives rise to the midbrain hindbrain boundary.	ZFA:0001187|TAO:0001187|EFO:0003446|XAO:0004086	hp.json	presumptive midbrain-hindbrain boundary|presumptive MHB|presumptive MHB	http://purl.obolibrary.org/obo/UBERON_0007281		efo_slim
UBERON:0007280	biolink:AnatomicalEntity	presumptive endocardium	A presumptive structure that has the potential to develop into a endocardium.	TAO:0002233|ZFA:0001724	hp.json		http://purl.obolibrary.org/obo/UBERON_0007280		
UBERON:0007289	biolink:AnatomicalEntity	presumptive rhombomere 1	A presumptive structure that has the potential to develop into a rhombomere 1.	ZFA:0001207|TAO:0001207	hp.json		http://purl.obolibrary.org/obo/UBERON_0007289		
UBERON:0007288	biolink:AnatomicalEntity	presumptive forebrain midbrain boundary	A presumptive structure that has the potential to develop into a forebrain-midbrain boundary.	EFO:0003463|ZFA:0001368|TAO:0001368	hp.json		http://purl.obolibrary.org/obo/UBERON_0007288		efo_slim
UBERON:0007285	biolink:AnatomicalEntity	presumptive paraxial mesoderm	The part of the blastula that has the potential to develop into a paraxial mesoderm.	XAO:0004134|ZFA:0000591|TAO:0000591|EFO:0003443	hp.json	future paraxial mesenchyme|future paraxial mesoderm	http://purl.obolibrary.org/obo/UBERON_0007285		efo_slim
UBERON:0007284	biolink:AnatomicalEntity	presumptive neural plate	A presumptive structure that has the potential to develop into a neural plate.	ZFA:0000063|EFO:0003424|TAO:0000063	hp.json	prospective vegetal ectoderm|prospective neuroectoderm	http://purl.obolibrary.org/obo/UBERON_0007284		efo_slim
UBERON:0019261	biolink:AnatomicalEntity	white matter of forebrain	A white matter that is part of the forebrain.	FMA:268634|DHBA:10557	hp.json		http://purl.obolibrary.org/obo/UBERON_0019261		human_reference_atlas
UBERON:0019258	biolink:AnatomicalEntity	white matter of hindbrain	A white matter that is part of the hindbrain.	FMA:268636|DHBA:10668	hp.json		http://purl.obolibrary.org/obo/UBERON_0019258		human_reference_atlas
UBERON:0019255	biolink:AnatomicalEntity	lower eyelash		FMA:59409	hp.json	lower eyelid cilium|lower eyelid cilia|eyelash of lower eyelid|hair of lower eyelid|lower eyelid eyelash	http://purl.obolibrary.org/obo/UBERON_0019255		pheno_slim
UBERON:0019253	biolink:AnatomicalEntity	upper secondary incisor tooth		FMA:55712	hp.json	maxillary secondary incisor tooth|upper permanent incisor tooth|upper permanent incisor	http://purl.obolibrary.org/obo/UBERON_0019253		
UBERON:0019254	biolink:AnatomicalEntity	upper eyelash		FMA:59408	hp.json	upper eyelid cilium|upper eyelid cilia|eyelash of upper eyelid|hair of upper eyelid|upper eyelid eyelash	http://purl.obolibrary.org/obo/UBERON_0019254		pheno_slim
UBERON:0007271	biolink:AnatomicalEntity	appendage musculature	Any collection of muscles that is part of an appendage.	TAO:0000207|ZFA:0000207	hp.json	fin musculature	http://purl.obolibrary.org/obo/UBERON_0007271		
UBERON:0007270	biolink:AnatomicalEntity	pelvic appendage musculature	Any collection of muscles that is part of a pelvic appendage.	ZFA:0000258|TAO:0000258	hp.json	pelvic fin musculature	http://purl.obolibrary.org/obo/UBERON_0007270		
GO:1904019	biolink:BiologicalProcess	epithelial cell apoptotic process	Any apoptotic process in an epithelial cell.		hp.json	epithelial cell apoptosis|epitheliocyte apoptosis|epitheliocyte apoptotic process	http://purl.obolibrary.org/obo/GO_1904019		
GO:1904018	biolink:BiologicalProcess	positive regulation of vasculature development	Any process that activates or increases the frequency, rate or extent of vasculature development.		hp.json	upregulation of vasculature development|up-regulation of vascular system development|up regulation of vascular system development|up-regulation of vasculature development|positive regulation of vascular system development|up regulation of vasculature development|activation of vasculature development|upregulation of vascular system development|activation of vascular system development	http://purl.obolibrary.org/obo/GO_1904018		
GO:1904015	biolink:BiologicalProcess	cellular response to serotonin	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_1904015		
GO:1904014	biolink:BiologicalProcess	response to serotonin	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a serotonin stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_1904014		
UBERON:0007279	biolink:AnatomicalEntity	presumptive atrioventricular canal	A presumptive structure that has the potential to develop into a atrioventricular canal.	ZFA:0001723|TAO:0002227	hp.json	future atrioventricular canal|future AV canal	http://purl.obolibrary.org/obo/UBERON_0007279		
UBERON:0007278	biolink:AnatomicalEntity	presumptive sinus venosus	Portion of tissue that is part of the heart tube and will become the sinus venosus.	ZFA:0001722|TAO:0002234	hp.json		http://purl.obolibrary.org/obo/UBERON_0007278		
UBERON:0007277	biolink:AnatomicalEntity	presumptive hindbrain	The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure.	FMA:295640|CALOHA:TS-2118|ZFA:0000569|EFO:0003440|TAO:0000569|BAMS:HB|EHDAA2:0001630|Wikipedia:Rhombencephalon	hp.json	future hindbrain|presumptive rhombencephalon|future hindbrain|rhombencephalon|embryonic rhombencephalon	http://purl.obolibrary.org/obo/UBERON_0007277		efo_slim
UBERON:0007273	biolink:AnatomicalEntity	pelvic appendage skeleton	The collection of all skeletal elements in a pelvic appendage region.		hp.json		http://purl.obolibrary.org/obo/UBERON_0007273		
UBERON:0007272	biolink:AnatomicalEntity	pectoral appendage skeleton	Skeletal subdivision consisting of the anterior appendicular limb skeleton, excluding the pectoral girdle.	VSAO:0005000	hp.json	cheiropterygium	http://purl.obolibrary.org/obo/UBERON_0007272		
UBERON:0019246	biolink:AnatomicalEntity	palmar skin crease			hp.json	skin crease of palmar part of manus	http://purl.obolibrary.org/obo/UBERON_0019246		pheno_slim
UBERON:0019247	biolink:AnatomicalEntity	plantar skin crease			hp.json	skin crease of plantar part of pes	http://purl.obolibrary.org/obo/UBERON_0019247		
UBERON:0019242	biolink:AnatomicalEntity	pedal digit 2, 3 or 4			hp.json	mesoaxial pedal digit|medial pedal digit|mesoxaxial ftoe	http://purl.obolibrary.org/obo/UBERON_0019242		pheno_slim
UBERON:0019243	biolink:AnatomicalEntity	skin crease			hp.json	skin groove	http://purl.obolibrary.org/obo/UBERON_0019243		
UBERON:0019241	biolink:AnatomicalEntity	pedal digit 1 or 5			hp.json	lateral pedal digit|outermost pedal digit|outer pedal digit|lateral toe	http://purl.obolibrary.org/obo/UBERON_0019241		
UBERON:0007260	biolink:AnatomicalEntity	intervertebral disk of third cervical vertebra	An intervertebral disk that connects a mammalian cervical vertebra 3 and connects a mammalian cervical vertebra 4.	FMA:13896|EMAPA:19422	hp.json	intervertebral disk, C3-C4|C3 intervertebral disk	http://purl.obolibrary.org/obo/UBERON_0007260		
GO:1904028	biolink:BiologicalProcess	positive regulation of collagen fibril organization	Any process that activates or increases the frequency, rate or extent of collagen fibril organization.		hp.json	upregulation of collagen fibril organisation|up-regulation of collagen fibril organization|activation of collagen fibril organization|up-regulation of fibrillar collagen organization|positive regulation of collagen fibril organisation|up regulation of fibrillar collagen organization|up regulation of collagen fibril organisation|upregulation of collagen fibril organization|positive regulation of fibrillar collagen organization|activation of fibrillar collagen organization|up-regulation of collagen fibril organisation|activation of collagen fibril organisation|upregulation of fibrillar collagen organization|up regulation of collagen fibril organization	http://purl.obolibrary.org/obo/GO_1904028		
GO:1904027	biolink:BiologicalProcess	negative regulation of collagen fibril organization	Any process that stops, prevents or reduces the frequency, rate or extent of collagen fibril organization.		hp.json	inhibition of collagen fibril organisation|down regulation of fibrillar collagen organization|negative regulation of collagen fibril organisation|downregulation of collagen fibril organization|down-regulation of collagen fibril organisation|inhibition of fibrillar collagen organization|downregulation of fibrillar collagen organization|down regulation of collagen fibril organization|inhibition of collagen fibril organization|down-regulation of collagen fibril organization|downregulation of collagen fibril organisation|negative regulation of fibrillar collagen organization|down-regulation of fibrillar collagen organization|down regulation of collagen fibril organisation	http://purl.obolibrary.org/obo/GO_1904027		
GO:1904026	biolink:BiologicalProcess	regulation of collagen fibril organization	Any process that modulates the frequency, rate or extent of collagen fibril organization.		hp.json	regulation of fibrillar collagen organization|regulation of collagen fibrillogenesis|regulation of collagen fibril organisation	http://purl.obolibrary.org/obo/GO_1904026		
GO:1904035	biolink:BiologicalProcess	regulation of epithelial cell apoptotic process	Any process that modulates the frequency, rate or extent of epithelial cell apoptotic process.		hp.json	regulation of epithelial cell apoptosis|regulation of epitheliocyte apoptosis|regulation of epitheliocyte apoptotic process	http://purl.obolibrary.org/obo/GO_1904035		
UBERON:0007267	biolink:AnatomicalEntity	trachea pre-cartilage rings	A pre-cartilage condensation that is part of a trachea.	EHDAA2:0002070|EHDAA:7082	hp.json		http://purl.obolibrary.org/obo/UBERON_0007267		
UBERON:0007266	biolink:AnatomicalEntity	intervertebral disk of atlas	An intervertebral disk that connects a vertebral bone 1 and connects a vertebral bone 2.	EMAPA:19416	hp.json	C1 intervertebral disk|intervertebral disc of cervical vertebra 1|intervertebral disc of first cervical vertebra|first cervical intervertebral disk|intervertebral disk of cervical vertebra 1|intervertebral disk, C1-C2|intervertebral disk of first cervical vertebra|C1 disk	http://purl.obolibrary.org/obo/UBERON_0007266		
UBERON:0007265	biolink:AnatomicalEntity	intervertebral disk of axis	An intervertebral disk that connects a vertebral bone 2 and connects a mammalian cervical vertebra 3.	EMAPA:19419|FMA:25058	hp.json	intervertebral disk of cervical vertebra 2|intervertebral disc of second cervical vertebra|second cervical intervertebral disk|intervertebral disk, C2-C3|C2 disk|intervertebral disk of second cervical vertebra|C2 intervertebral disk|intervertebral disc of cervical vertebra 2	http://purl.obolibrary.org/obo/UBERON_0007265		
UBERON:0007264	biolink:AnatomicalEntity	intervertebral disk of seventh cervical vertebra	An intervertebral disk that connects a thoracic vertebra and connects a mammalian cervical vertebra 7.	FMA:13900|EMAPA:19463	hp.json	intervertebral disk, C7-T1	http://purl.obolibrary.org/obo/UBERON_0007264		
UBERON:0007263	biolink:AnatomicalEntity	intervertebral disk of sixth cervical vertebra	An intervertebral disk that connects a mammalian cervical vertebra 6 and connects a mammalian cervical vertebra 7.	FMA:13899|EMAPA:19460	hp.json	intervertebral disk, C6-C7	http://purl.obolibrary.org/obo/UBERON_0007263		
UBERON:0007262	biolink:AnatomicalEntity	intervertebral disk of fifth cervical vertebra	An intervertebral disk that connects a mammalian cervical vertebra 5 and connects a mammalian cervical vertebra 6.	FMA:13898|EMAPA:19428	hp.json	intervertebral disk, C5-C6|intervertebral disc of fifth cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0007262		
UBERON:0007261	biolink:AnatomicalEntity	intervertebral disk of fourth cervical vertebra	An intervertebral disk that connects a mammalian cervical vertebra 4 and connects a mammalian cervical vertebra 5.	FMA:13897|EMAPA:19425	hp.json	intervertebral disc of fourth cervical vertebra|intervertebral disk, C4-C5	http://purl.obolibrary.org/obo/UBERON_0007261		
UBERON:0007269	biolink:AnatomicalEntity	pectoral appendage musculature	Any collection of muscles that is part of a pectoral appendage.	EFO:0003540|ZFA:0000563|TAO:0000563	hp.json	pectoral fin musculature|pectoral fin muscle	http://purl.obolibrary.org/obo/UBERON_0007269		efo_slim
GO:0005856	biolink:CellularComponent	cytoskeleton	Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.	Wikipedia:Cytoskeleton	hp.json		http://purl.obolibrary.org/obo/GO_0005856		goslim_drosophila|goslim_chembl|goslim_aspergillus|goslim_mouse|goslim_agr|goslim_yeast|goslim_generic|goslim_candida|goslim_pir|goslim_plant|goslim_flybase_ribbon
UBERON:0009953	biolink:AnatomicalEntity	post-embryonic organism	A multicellular organism that existence_starts_with a post-embryonic stage.	MA:0002405	hp.json	postnatal mouse|postnatal organism|post-hatching organism|post-natal organism|TS28 mouse|post-natal organism|post-hatching organism	http://purl.obolibrary.org/obo/UBERON_0009953		
UBERON:0010932	biolink:AnatomicalEntity	crico-arytenoid muscle	Cricoarytenoid muscles are muscles that connect the cricoid cartilage and arytenoid cartilage. More specifically, it can refer to: Posterior cricoarytenoid muscle Lateral cricoarytenoid muscle.	UMLS:C0448336|NCIT:C32398|EMAPA:37498|MA:0002283	hp.json	cricoarytenoideus|cricoarytenoid muscle|cricoarytenoid|crico-arytenoid	http://purl.obolibrary.org/obo/UBERON_0010932		non_informative|grouping_class
UBERON:0009955	biolink:AnatomicalEntity	neurogenic placode	Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia.	ZFA:0001309|TAO:0001309|EFO:0003460|Wikipedia:Neurogenic_placodes|XAO:0004620	hp.json	neurogenic placodes|placodae neurogenicae|placodae neurogenicae	http://purl.obolibrary.org/obo/UBERON_0009955		efo_slim
UBERON:0034901	biolink:AnatomicalEntity	cervical sympathetic nerve trunk	The cervical ganglia are paravertebral ganglia of the sympathetic nervous system. These emerging postganglionic nerves synapse with preganglionic nerves from the thoracic spinal cord. They consist of three paravertebral ganglia: superior cervical ganglion middle cervical ganglion inferior cervical ganglion. The inferior ganglion may be fused with the first thoracic ganglion to form a single structure, the stellate ganglion. Nerves emerging from cervical sympathetic ganglia contribute to the cardiac plexus, among other things.	FMA:6261	hp.json	cervical part of sympathetic trunk|cervical sympathetic trunk|cervical sympathetic chain	http://purl.obolibrary.org/obo/UBERON_0034901		
UBERON:0034902	biolink:AnatomicalEntity	sacral sympathetic nerve trunk		FMA:6264|EMAPA:37656|MA:0001164	hp.json	sacral sympathetic chain|pelvic sympathetic nerve trunk|pelvic sympathetic trunk|sacral part of sympathetic trunk|sacral sympathetic trunk	http://purl.obolibrary.org/obo/UBERON_0034902		
UBERON:0010935	biolink:AnatomicalEntity	tensor tympani pre-muscle condensation		EHDAA2:0002002	hp.json		http://purl.obolibrary.org/obo/UBERON_0010935		
UBERON:0034903	biolink:AnatomicalEntity	left atrium endocardium	Endocardium that is part of the left atrium.	FMA:7286|SCTID:190064008|VHOG:0001226	hp.json	left atrium endocardial tissue|endocardium of left atrium|left atrial endocardium	http://purl.obolibrary.org/obo/UBERON_0034903		
UBERON:0009958	biolink:AnatomicalEntity	bladder lumen	An anatomical space that is enclosed by a urinary bladder.	FMA:15924|EHDAA2:0004058|galen:UrinaryBladderCavity	hp.json	cavity of urinary bladder|urinary bladder lumen|lumen of urinary bladder|bladder cavity	http://purl.obolibrary.org/obo/UBERON_0009958		
UBERON:0010933	biolink:AnatomicalEntity	orbicularis oris muscle	The orbicularis oris is a superficial facial muscle with fibers that encircle the opening of the oral cavity that attaches to the maxilla, mandible, skin and modiolus, and that participates in oral/pharyngeal behaviors, and is innervated by the facial nerve (CN VII).	FMA:46841|MFMO:0000058	hp.json	orbicularis oris|incisivii labii superioris|incisivii labii inferioris|musculus orbicularis oris|orbicularis oris|nasolabialis muscle	http://purl.obolibrary.org/obo/UBERON_0010933		
UBERON:0034905	biolink:AnatomicalEntity	gland lumen			hp.json	lumen of gland	http://purl.obolibrary.org/obo/UBERON_0034905		
UBERON:0034907	biolink:AnatomicalEntity	pineal parenchyma	Parenchymal tissue that forms the pineal gland.	NCIT:C41834	hp.json		http://purl.obolibrary.org/obo/UBERON_0034907		
UBERON:0034908	biolink:AnatomicalEntity	scapular muscle	Any of the muscles that are responsible for moving the scapula. In humans these are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034908		
UBERON:0010938	biolink:AnatomicalEntity	muscle belly		FMA:9719	hp.json	belly|venter|belly of muscle	http://purl.obolibrary.org/obo/UBERON_0010938		
UBERON:0034909	biolink:AnatomicalEntity	intermaxillary suture	A cranial suture in the midline of the skull that connects the left and right maxilla bones.	FMA:52963	hp.json	intermaxillary suture of skull	http://purl.obolibrary.org/obo/UBERON_0034909		
CHEBI:30363	biolink:ChemicalSubstance	isobutane	An alkane that is propane substituted by a methyl group at position 2.	KEGG:D04623|PMID:24179026|CAS:75-28-5|Gmelin:1301|Wikipedia:Isobutane|Beilstein:1730720|Reaxys:1730720|CAS:75-28-5|PMID:24464945	hp.json	R-600a|(CH3)2CH-CH3|E943b|isobutane|2-methylpropane	http://purl.obolibrary.org/obo/CHEBI_30363		3_STAR
CHEBI:17381	biolink:ChemicalSubstance	porphobilinogen	A dicarboxylic acid that is pyrole bearing aminomethyl, carboxymethyl and 2-carboxyethyl substituents at positions 2, 3 and 4 respectively.	PMID:21383008|KNApSAcK:C00007339|PMID:22740490|Beilstein:220051|DrugBank:DB02272|PMID:22770225|PDBeChem:PBG|Reaxys:220051|PMID:21627493|HMDB:HMDB0000245|CAS:487-90-1|CAS:487-90-1|PMID:22279024|MetaCyc:PORPHOBILINOGEN|PMID:22974111|Wikipedia:Porphobilinogen|KEGG:C00931	hp.json	3-[5-(aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid|Porphobilinogen	http://purl.obolibrary.org/obo/CHEBI_17381		3_STAR
GO:0003205	biolink:BiologicalProcess	cardiac chamber development	The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003205		
GO:0003204	biolink:BiologicalProcess	cardiac skeleton development	The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.		hp.json	heart fibrous skeleton development	http://purl.obolibrary.org/obo/GO_0003204		
GO:0003207	biolink:BiologicalProcess	cardiac chamber formation	The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.		hp.json	heart chamber formation	http://purl.obolibrary.org/obo/GO_0003207		
GO:0003206	biolink:BiologicalProcess	cardiac chamber morphogenesis	The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.		hp.json	heart chamber morphogenesis	http://purl.obolibrary.org/obo/GO_0003206		
GO:0003203	biolink:BiologicalProcess	endocardial cushion morphogenesis	The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.		hp.json		http://purl.obolibrary.org/obo/GO_0003203		
UBERON:0010929	biolink:AnatomicalEntity	stapedius pre-muscle condensation		EHDAA2:0001909	hp.json		http://purl.obolibrary.org/obo/UBERON_0010929		
CHEBI:17376	biolink:ChemicalSubstance	cystine	A sulfur-containing amino acid obtained by the oxidation of two cysteine molecules which are then linked via a disulfide bond.	Wikipedia:Cystine|PMID:18608550|Reaxys:1728091|Beilstein:1728091|Gmelin:83347|PMID:24525030|PMID:24327171|KEGG:C01420|PMID:24525029|CAS:923-32-0|CAS:923-32-0	hp.json	3,3'-disulfanediylbis(2-aminopropanoic acid)|Dicysteine|3,3'-dithiobis(2-aminopropanoic acid)|Cystin|alpha-Diamino-beta-dithiolactic acid|cystine|Zystin|cistina|Cystine	http://purl.obolibrary.org/obo/CHEBI_17376		3_STAR
GO:0003209	biolink:BiologicalProcess	cardiac atrium morphogenesis	The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.		hp.json		http://purl.obolibrary.org/obo/GO_0003209		
CHEBI:17375	biolink:ChemicalSubstance	(2S)-2-hydroxy monocarboxylic acid	A 2-hydroxy monocarboxylic acid in which the carbon at position 2 has (S)-configuration.		hp.json	(S)-2-Hydroxyalkanoic acid|(S)-2-Hydroxy acid|(S)-2-Hydroxycarboxylic acid|(S)-2-hydroxy acid|(S)-2-Hydroxymonocarboxylic acid|(2S)-2-hydroxy monocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_17375		3_STAR
GO:0003208	biolink:BiologicalProcess	cardiac ventricle morphogenesis	The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003208		
HP:0002597	biolink:PhenotypicFeature	Abnormality of the vasculature	An abnormality of the vasculature.	UMLS:C0241657	hp.json	Vascular abnormalities|Abnormality of the vasculature|Abnormality of blood vessels	http://purl.obolibrary.org/obo/HP_0002597		
UBERON:0034921	biolink:AnatomicalEntity	multi organ part structure	An multicellular anatomical structure that has subparts of multiple organs as a part.	CARO:0020001	hp.json	anatomical cluster	http://purl.obolibrary.org/obo/UBERON_0034921		
HP:0002595	biolink:PhenotypicFeature	Ileus	Acute obstruction of the intestines preventing passage of the contents of the intestines.	UMLS:C1258215|MEDDRA:10021328|MSH:D045823	hp.json	Gastrointestinal atony	http://purl.obolibrary.org/obo/HP_0002595		hposlim_core
UBERON:0034922	biolink:AnatomicalEntity	cell cluster	A cluster of cells, largely surrounded by a morphological boundary.	CARO:0020002|FMA:62807	hp.json		http://purl.obolibrary.org/obo/UBERON_0034922		
UBERON:0034923	biolink:AnatomicalEntity	disconnected anatomical group	Material anatomical entity consisting of multiple anatomical structures that are not connected to each other.	FBbt:00007276|CARO:0020000	hp.json		http://purl.obolibrary.org/obo/UBERON_0034923		
UBERON:0010913	biolink:AnatomicalEntity	vertebral element	Skeletal element that forms around the notochord and is part of the vertebral column.	VHOG:0001143|VSAO:0000184	hp.json	vertebra skeletal element|vertebra element|vertebra endochondral element|vertebral endochondral element	http://purl.obolibrary.org/obo/UBERON_0010913		
UBERON:0034925	biolink:AnatomicalEntity	anatomical collection	A collection of anatomical structures that are alike in terms of their morphology or developmental origin.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034925		
UBERON:0010911	biolink:AnatomicalEntity	ossicle	Skeletal element that is often isolated, small, and variable in composition.	VSAO:0000132	hp.json		http://purl.obolibrary.org/obo/UBERON_0010911		
HP:0002599	biolink:PhenotypicFeature	Head titubation	A head tremor of moderate speed (3 to 4 Hz) in the anterior-posterior direction.	UMLS:C1608410	hp.json		http://purl.obolibrary.org/obo/HP_0002599		
UBERON:0034926	biolink:AnatomicalEntity	anatomical row	An anatomical collection that is arranged in a line.	FBbt:00100152	hp.json		http://purl.obolibrary.org/obo/UBERON_0034926		
UBERON:0010912	biolink:AnatomicalEntity	subdivision of skeleton	Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.	SCTID:129140006|VSAO:0000042|FMA:23879	hp.json	subdivision of skeleton (in vivo)|skeletal subdivision	http://purl.obolibrary.org/obo/UBERON_0010912		non_informative
UBERON:0034928	biolink:AnatomicalEntity	dorsal surface of penis		FMA:19623	hp.json	dorsum penis|dorsum of penis	http://purl.obolibrary.org/obo/UBERON_0034928		
UBERON:0034929	biolink:AnatomicalEntity	external soft tissue zone	A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034929		
HP:0002590	biolink:PhenotypicFeature	Paralytic ileus		SNOMEDCT_US:55525008|UMLS:C0030446|MSH:D007418	hp.json		http://purl.obolibrary.org/obo/HP_0002590		
CHEBI:78320	biolink:ChemicalSubstance	2-hydroxypropanoic acid	A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	CAS:50-21-5|KEGG:C01432|KEGG:D00111	hp.json	2-Hydroxypropanoic acid|Lactic acid|2-hydroxypropanoic acid|2-Hydroxypropionic acid	http://purl.obolibrary.org/obo/CHEBI_78320		3_STAR
HP:0002593	biolink:PhenotypicFeature	Intestinal lymphangiectasia	Angiectasia of lymph vessels (i.e., dilatation of lymphatic vessels) in the intestines.	UMLS:C0024215|MSH:D008201|SNOMEDCT_US:197260007	hp.json		http://purl.obolibrary.org/obo/HP_0002593		
HP:0002594	biolink:PhenotypicFeature	Pancreatic hypoplasia	Hypoplasia of the pancreas.	UMLS:C0266267|SNOMEDCT_US:68591005	hp.json	Hypoplastic pancreas|Underdeveloped pancreas	http://purl.obolibrary.org/obo/HP_0002594		
HP:0002591	biolink:PhenotypicFeature	Polyphagia	A neurological anomaly with gross overeating associated with an abnormally strong desire or need to eat.	MSH:D006963|SNOMEDCT_US:72405004|SNOMEDCT_US:58424009|UMLS:C0232461|UMLS:C0020505|SNOMEDCT_US:267023007	hp.json	Increased appetite|Hyperphagia|Voracious appetite	http://purl.obolibrary.org/obo/HP_0002591		
HP:0002592	biolink:PhenotypicFeature	Gastric ulcer	An ulcer, that is, an erosion of an area of the gastric mucous membrane.	MSH:D013276|UMLS:C0038358|SNOMEDCT_US:397825006|MEDDRA:10017822	hp.json	Stomach ulcer	http://purl.obolibrary.org/obo/HP_0002592		hposlim_core
GO:0005840	biolink:CellularComponent	ribosome	An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.	Wikipedia:Ribosome|NIF_Subcellular:sao1429207766	hp.json	free ribosome|membrane bound ribosome|ribosomal RNA	http://purl.obolibrary.org/obo/GO_0005840		goslim_metagenomics|goslim_aspergillus|goslim_chembl|goslim_generic|goslim_yeast|goslim_candida|goslim_plant|goslim_pir
UBERON:0009917	biolink:AnatomicalEntity	kidney corticomedullary boundary	The region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary.	EMAPA:37886	hp.json		http://purl.obolibrary.org/obo/UBERON_0009917		pheno_slim
UBERON:0009919	biolink:AnatomicalEntity	ureter smooth muscle	The smooth muscle tissue surrounding the epithelium of the ureter.	EMAPA:28811	hp.json	ureteral smooth muscle|ureteral smooth muscle layer	http://purl.obolibrary.org/obo/UBERON_0009919		pheno_slim|human_reference_atlas
UBERON:0034940	biolink:AnatomicalEntity	venous sinus cavity	An enlarged chamber in the blood sinus capable of accumulating a large volume of blood.	ZFA:0007073	hp.json	blood sinus cavity|blood sinus lumen	http://purl.obolibrary.org/obo/UBERON_0034940		
UBERON:0009920	biolink:AnatomicalEntity	optic neural crest		EHDAA:1122|EHDAA2:0001315	hp.json		http://purl.obolibrary.org/obo/UBERON_0009920		
UBERON:0034932	biolink:AnatomicalEntity	epithelium of biliary system	The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts.	BTO:0001513	hp.json	biliary epithelium|biliary system epithelium|biliary tract epithelium	http://purl.obolibrary.org/obo/UBERON_0034932		
UBERON:0034933	biolink:AnatomicalEntity	layer of smooth muscle tissue	Any organ component layer that consists of smooth muscle tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034933		
CHEBI:30356	biolink:ChemicalSubstance	isobutyl group			hp.json	(CH3)2CH-CH2-|2-methylpropan-1-ido|iBu|leucine side-chain|2-methylpropyl|-CH2-CH(CH3)2|isobutyl	http://purl.obolibrary.org/obo/CHEBI_30356		3_STAR
CHEBI:30353	biolink:ChemicalSubstance	isopropyl group			hp.json	valine side-chain|(CH3)2CH-|iPr|1-methylethyl|-CH(CH3)2|isopropyl|propan-2-yl	http://purl.obolibrary.org/obo/CHEBI_30353		3_STAR
UBERON:0010905	biolink:AnatomicalEntity	clavicle bone primordium	A primordium that develops into a clavicle bone.	EHDAA2:0000254	hp.json	clavicle primordium	http://purl.obolibrary.org/obo/UBERON_0010905		
CHEBI:29337	biolink:ChemicalSubstance	azanide			hp.json	azanide|amide|dihydridonitrate(1-)|NH2(-)	http://purl.obolibrary.org/obo/CHEBI_29337		3_STAR
CHEBI:32988	biolink:ChemicalSubstance	amide	An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.	KEGG:C00241	hp.json	Amide|amides	http://purl.obolibrary.org/obo/CHEBI_32988		3_STAR
UBERON:0019319	biolink:AnatomicalEntity	exocrine gland of integumental system	An exocrine gland that is part of a integumental system.		hp.json	integumental exocrine gland|integumental exocrine gland|integumental system exocrine gland|integumental system exocrine gland	http://purl.obolibrary.org/obo/UBERON_0019319		
UBERON:0010982	biolink:AnatomicalEntity	latissimus dorsi pre-muscle mass		EHDAA2:0000933	hp.json		http://purl.obolibrary.org/obo/UBERON_0010982		
UBERON:0010983	biolink:AnatomicalEntity	levator scapulae pre-muscle mass		EHDAA2:0000993	hp.json		http://purl.obolibrary.org/obo/UBERON_0010983		
UBERON:0019315	biolink:AnatomicalEntity	meibum	An oily substance that prevents evaporation of the eye's tear film.		hp.json	tarsal gland secretion	http://purl.obolibrary.org/obo/UBERON_0019315		
UBERON:0010975	biolink:AnatomicalEntity	external oblique pre-muscle mass		EHDAA2:0000470	hp.json		http://purl.obolibrary.org/obo/UBERON_0010975		
CHEBI:17347	biolink:ChemicalSubstance	testosterone	An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5..	Beilstein:1915399|Wikipedia:Testosterone|LIPID_MAPS_instance:LMST02020002|Reaxys:1915399|DrugBank:DB00624|CAS:58-22-0|PDBeChem:TES|Drug_Central:2607|KEGG:D00075|HMDB:HMDB0000234|PMID:24498482|CAS:58-22-0|CAS:58-22-0|PMID:10438974|PMID:11786693|Gmelin:538843|KEGG:C00535|Beilstein:3653705|KNApSAcK:C00003675|PMID:18900503	hp.json	17beta-Hydroxy-4-androsten-3-one|Testosterone|17beta-hydroxyandrost-4-en-3-one|Androderm|testosterone|TESTOSTERONE|4-androsten-17beta-ol-3-one|17beta-hydroxy-4-androsten-3-one|testosterone|testosterona|Testosteron|testosteronum	http://purl.obolibrary.org/obo/CHEBI_17347		3_STAR
UBERON:0010977	biolink:AnatomicalEntity	flexor pre-muscle mass		EHDAA2:0000543	hp.json		http://purl.obolibrary.org/obo/UBERON_0010977		
OBO:cl#lacks_plasma_membrane_part	biolink:NamedThing	lacks_plasma_membrane_part			hp.json		http://purl.obolibrary.org/obo/cl#lacks_plasma_membrane_part		
UBERON:0019307	biolink:AnatomicalEntity	epithelium of external nose	Epithelial layer that is part of the external part of the nose.	FMA:63143	hp.json	epithelium of skin of external nose	http://purl.obolibrary.org/obo/UBERON_0019307		
CHEBI:29347	biolink:ChemicalSubstance	monocarboxylic acid amide	A carboxamide derived from a monocarboxylic acid.		hp.json	monocarboxylic acid amides	http://purl.obolibrary.org/obo/CHEBI_29347		3_STAR
CHEBI:29340	biolink:ChemicalSubstance	hydridonitrate(2-)	A divalent inorganic anion resulting from the removal of two protons from ammonia.		hp.json	NH(2-)|hydridonitrate(2-)|azanediide|imide	http://purl.obolibrary.org/obo/CHEBI_29340		3_STAR
UBERON:0019306	biolink:AnatomicalEntity	nose epithelium		MA:0003171|EMAPA:35958	hp.json		http://purl.obolibrary.org/obo/UBERON_0019306		
UBERON:0019304	biolink:AnatomicalEntity	sensory organ epithelium		MA:0003174|EMAPA:35952	hp.json		http://purl.obolibrary.org/obo/UBERON_0019304		
UBERON:0010970	biolink:AnatomicalEntity	intercostal pre-muscle mass		EHDAA2:0000843	hp.json		http://purl.obolibrary.org/obo/UBERON_0010970		
UBERON:0009988	biolink:AnatomicalEntity	condyle of humerus	The distal end of the humerus, including the trochlea, capitulum and the olecranon, coronoid and radial fossae.	FMA:23377	hp.json	condylus humeri|humeral condyle	http://purl.obolibrary.org/obo/UBERON_0009988		
UBERON:0010962	biolink:AnatomicalEntity	extensor pre-muscle mass		EHDAA2:0000459	hp.json		http://purl.obolibrary.org/obo/UBERON_0010962		
UBERON:0010963	biolink:AnatomicalEntity	trunk and cervical myotome group		EHDAA2:0003425	hp.json		http://purl.obolibrary.org/obo/UBERON_0010963		
UBERON:0009989	biolink:AnatomicalEntity	condyle of tibia	One of the lateral or medial condyles of the tibia.	AAO:0000899	hp.json	tibial condyle	http://purl.obolibrary.org/obo/UBERON_0009989		human_reference_atlas
CHEBI:91316	biolink:ChemicalSubstance	(S)-methylsuccinic acid	A 2-methylbutanedioic acid in which the methyl group at position 2 has S-configuration.	Reaxys:1722948	hp.json	(S)-2-methylbutanedioic acid|(2S)-2-methylbutanedioic acid	http://purl.obolibrary.org/obo/CHEBI_91316		3_STAR
CHEBI:91317	biolink:ChemicalSubstance	(R)-methylsuccinic acid	A 2-methylbutanedioic acid in which the methyl group at position 2 has R-configuration.	CAS:3641-51-8|Reaxys:1722947	hp.json	d-Methylsuccinic acid|(2R)-2-methylbutanedioic acid|(R)-2-methylbutanedioic acid	http://purl.obolibrary.org/obo/CHEBI_91317		3_STAR
UBERON:0007329	biolink:AnatomicalEntity	pancreatic duct	A duct that collects and carries secretions of the exocrine pancreas to the intestine.	TAO:0001372|MESH:D010183|VHOG:0000254|FMA:10419|MA:0000124|EHDAA:9194|ZFA:0001372|EMAPA:32952	hp.json	duct of pancreas|ductus pancreaticus|pancreas duct	http://purl.obolibrary.org/obo/UBERON_0007329		human_reference_atlas|vertebrate_core|pheno_slim
UBERON:0009980	biolink:AnatomicalEntity	condyle of femur	A condyle that is part of a distal epiphysis of femur.	AAO:0000900|FMA:32855|NCIT:C114186|galen:FemoralCondyle	hp.json	condylus femoris|femoral condyle|condylus femoralis|fibular condyle	http://purl.obolibrary.org/obo/UBERON_0009980		human_reference_atlas
CHEBI:91315	biolink:ChemicalSubstance	2-methylbutanedioic acid	A dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group.		hp.json	2-methylbutanedioic acid	http://purl.obolibrary.org/obo/CHEBI_91315		3_STAR
UBERON:0009984	biolink:AnatomicalEntity	medial condyle of femur	The medial condyle is one of the two projections on the lower extremity of femur. The medial condyle is larger than the lateral (outer) condyle due to more weight bearing caused by the center of gravity being medial to the knee. On the posterior surface of the condyle the linea aspera (a ridge running down the posterior shaft of the femur) turns into the medial supracondylar ridge. The outermost protrusion on the medial surface of the medial condyle is referred to as the 'medial epicondyle' and can be palpated by running fingers medially from the patella with the knee in flexion.	FMA:32858	hp.json	c. medialis femoris|c. medialis femoris|medial condyle of the femur|condylus medialis femoris|medial femoral condyle	http://purl.obolibrary.org/obo/UBERON_0009984		human_reference_atlas
UBERON:0007324	biolink:AnatomicalEntity	pancreatic lobule	A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans.	MA:0000721|FMA:16012|EMAPA:37710	hp.json	pancreatic lobule|pancreas lobe|lobulus pancreaticus	http://purl.obolibrary.org/obo/UBERON_0007324		human_reference_atlas
CHEBI:32964	biolink:ChemicalSubstance	ornithinate		Gmelin:1242186	hp.json	2,5-diaminopentanoate|ornithinate|ornithine anion	http://purl.obolibrary.org/obo/CHEBI_32964		3_STAR
UBERON:0007312	biolink:AnatomicalEntity	pudendal artery	Either the internal or external pudendal arteries.	EMAPA:37111|MA:0002028	hp.json	arteriae pudendales|arteriae pudendae|arteriae pudendae	http://purl.obolibrary.org/obo/UBERON_0007312		
UBERON:0010953	biolink:AnatomicalEntity	nasalis muscle	The nasalis (compressor naris) is a sphincter-like muscle of the nose whose function is to compress the nasal cartilage. It consists of two parts, transverse and alar: The transverse part arises from the maxilla, above and lateral to the incisive fossa; its fibers proceed upward and medially, expanding into a thin aponeurosis which is continuous on the bridge of the nose with that of the muscle of the opposite side, and with the aponeurosis of the Procerus. The alar part is attached at one end to the greater alar cartilage, and at the other to the integument at the point of the nose. Other sources divide it into 'Compressor nasalis' and 'Dilator nasalis'.	FMA:46770	hp.json	compressor nasi|musculus nasalis|compressor narium minor|nasalis|compressor naris	http://purl.obolibrary.org/obo/UBERON_0010953		
UBERON:0010952	biolink:AnatomicalEntity	frontalis muscle belly	A belly of the occipitofrontalis muscle that is near the frontal bone.	FMA:46757	hp.json	venter frontalis (musculus occipitofrontalis)|orbito-temporo-auricularis|venter frontalis musculi occipitofrontalis|frontalis muscke|frontalis|venter frontalis musculus occipitofrontalis|frontal belly of occipitofrontalis|frontal belly of occipitofrontalis muscle|frontal part of occipitofrontalis	http://purl.obolibrary.org/obo/UBERON_0010952		pheno_slim
UBERON:0009979	biolink:AnatomicalEntity	condyle	An articular prominence of a bone, typically present in pairs, resembling a pair of knuckles. Examples: Condyle of humerus, condyle of femur.	galen:Condyle|NCIT:C83002|TAO:0002259|UMLS:C0524414|FMA:75434	hp.json	condylus	http://purl.obolibrary.org/obo/UBERON_0009979		
UBERON:0010955	biolink:AnatomicalEntity	trapezius pre-muscle mass		EHDAA2:0002079	hp.json		http://purl.obolibrary.org/obo/UBERON_0010955		
PR:000028527	biolink:Protein	casein derived peptide	A proteolytic cleavage product that is derived from any of the casein milk proteins.		hp.json	CN (f)	http://purl.obolibrary.org/obo/PR_000028527		
CHEBI:17368	biolink:ChemicalSubstance	hypoxanthine	A purine nucleobase that consists of purine bearing an oxo substituent at position 6.	Wikipedia:Hypoxanthine|MetaCyc:HYPOXANTHINE|HMDB:HMDB0000157|KNApSAcK:C00001502|Beilstein:5811|PMID:23400363|CAS:68-94-0|Reaxys:5811|PMID:22735334|ECMDB:ECMDB00157|CAS:68-94-0|PDBeChem:HPA|PMID:8016081|CAS:68-94-0|DrugBank:DB04076|PMID:14253484|Gmelin:464558|PMID:1557408|PMID:23670363|KEGG:C00262|YMDB:YMDB00555	hp.json	purin-6(1H)-one|Purine-6-ol|Hypoxanthine|HYPOXANTHINE|1,7-dihydro-6H-purin-6-one|hypoxanthine|6-oxopurine|6(1H)-purinone|9H-purin-6(1H)-one|Hyp	http://purl.obolibrary.org/obo/CHEBI_17368		3_STAR
UBERON:0010959	biolink:AnatomicalEntity	craniocervical muscle	Any muscle organ that is part of either the head or the neck.	UMLS:C0448281|NCIT:C32716	hp.json	muscle of head and neck|muscle of head or neck	http://purl.obolibrary.org/obo/UBERON_0010959		
UBERON:0009970	biolink:AnatomicalEntity	epithelium of pancreatic duct	An epithelium that is part of a pancreatic duct.	FMA:67681|EFO:0002556	hp.json	pancreatic duct epithelium|pancreatic ductal epithelium	http://purl.obolibrary.org/obo/UBERON_0009970		efo_slim
CHEBI:17364	biolink:ChemicalSubstance	D-aspartic acid	The D-enantiomer of aspartic acid.	PMID:11419736|PMID:17407322|DrugBank:DB02655|KEGG:C00402|PMID:18318836|CAS:1783-96-6|PDBeChem:DAS|HMDB:HMDB0006483|PMID:17118457|CAS:1783-96-6|MetaCyc:CPD-302|CAS:1783-96-6|Beilstein:1723529|Reaxys:1723529|Gmelin:602084|PMID:19860889	hp.json	aspartic acid D-form|D-Asparaginsaeure|D-Aspartic acid|DAS|(2R)-2-aminobutanedioic acid|(R)-2-aminosuccinic acid|D-aspartic acid|(R)-2-aminobutanedioic acid	http://purl.obolibrary.org/obo/CHEBI_17364		3_STAR
UBERON:0007315	biolink:AnatomicalEntity	internal pudendal artery	The internal pudendal artery is an artery that branches off the internal iliac artery, providing blood to the external genitalia. The internal pudendal artery is the terminal branch of the anterior trunk of the internal iliac artery. It is smaller in the female than in the male.	FMA:18835	hp.json	arteriae pudendae interna|arteriae pudendae interna|internal pudendal vessels|arteriae pudendales interna|arteria pudenda interna|internal pudic artery	http://purl.obolibrary.org/obo/UBERON_0007315		human_reference_atlas
UBERON:0009972	biolink:AnatomicalEntity	ureteropelvic junction	The junction between the ureter and the renal pelvis of the kidney.	NCIT:C106203|MA:0003021|FMA:15898|EMAPA:37782	hp.json	pelvoureteric junction|pelviureteric junction	http://purl.obolibrary.org/obo/UBERON_0009972		pheno_slim
UBERON:0009973	biolink:AnatomicalEntity	ureterovesical junction	The valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney.	NCIT:C106202|EMAPA:37783|MA:0003020|FMA:15899	hp.json	vesico-ureteral junction|vesicoureteric junction|vesico-ureteric junction	http://purl.obolibrary.org/obo/UBERON_0009973		pheno_slim
UBERON:0009974	biolink:AnatomicalEntity	lumen of Rathke's pouch	An anatomical cavity that surrounded_by a Rathke's pouch.	EMAPA:25037|EHDAA2:0004138	hp.json	Rathkes pouch invagination	http://purl.obolibrary.org/obo/UBERON_0009974		
UBERON:0007301	biolink:AnatomicalEntity	appendage blood vessel	A blood vessel that is part of a limb/fin.	TAO:0005299|ZFA:0005299	hp.json	fin blood vessel|limb blood vessel	http://purl.obolibrary.org/obo/UBERON_0007301		
UBERON:0010943	biolink:AnatomicalEntity	anterior digastric muscle	The anterior digastric is a pharyngeal arch I muscle that participates in oral/pharygeal behaviors and is innervated by the nerve to mylohyoid (a branch of the third division of the trigeminal nerve), is attached to the mandible and to the hyoid apparatus, and it is superficial to mylohyoid muscle.	EMAPA:37405|FMA:46302	hp.json	venter anterior (musculus digastricus)|digastric, anterior|digastricus anterior|anterior digastric muscle|venter posterior musculus digastrici anterior|anterior belly of digastric muscle|digastricus, venter rostralis|anterior digastric|anterior belly of digastric|digastricus anterior belly	http://purl.obolibrary.org/obo/UBERON_0010943		feed_aligned
UBERON:0007300	biolink:AnatomicalEntity	pectoral appendage blood vessel	A blood vessel that is part of a pectoral appendage.	ZFA:0005301|TAO:0005301	hp.json	pectoral fin blood vessel	http://purl.obolibrary.org/obo/UBERON_0007300		
UBERON:0010940	biolink:AnatomicalEntity	muscle of digastric group	Either of the two muscles that comprise the digastric group (anterior or posterior).	FMA:46297	hp.json	digastric|digastricus|musculus digastricus|digastric belly|digastric muscle|belly of digastric|muscle body proper of digastric|belly of digastric muscle	http://purl.obolibrary.org/obo/UBERON_0010940		
CHEBI:32970	biolink:ChemicalSubstance	2-aminoethanesulfonate	A 1,1-diunsubstituted alkanesulfonate that is ethanesulfonate substituted by an amino group at position 2.	Beilstein:3588289|Reaxys:3588289	hp.json	2-aminoethanesulfonate	http://purl.obolibrary.org/obo/CHEBI_32970		3_STAR
UBERON:0010946	biolink:AnatomicalEntity	occipitofrontalis muscle	The occipitofrontalis or epicranius is a muscle which covers parts of the skull. It consists of two parts or bellies: The occipital belly, near the occipital bone, and the frontal belly, near the frontal bone.	FMA:9624|NCIT:C33198|UMLS:C1518531	hp.json	epicranius|occipito-frontalis|musculus occipitofrontalis|occipitofrontalis	http://purl.obolibrary.org/obo/UBERON_0010946		
CHEBI:17359	biolink:ChemicalSubstance	sulfite	A sulfur oxoanion that is the conjugate base of hydrogen sulfite (H2SO3).	CAS:14265-45-3|PDBeChem:SO3|Gmelin:1449	hp.json	[SO3](2-)|sulphite|SO3|sulfite|trioxosulfate(2-)|trioxosulfate(IV)|sulfite|trioxidosulfate(2-)|SO3(2-)|SULFITE ION	http://purl.obolibrary.org/obo/CHEBI_17359		3_STAR
UBERON:0007307	biolink:AnatomicalEntity	pronephric glomerular basement membrane	A glomerular basement membrane that is part of a pronephros.	TAO:0005313|ZFA:0005313	hp.json	pronephric glomerular filtration membrane	http://purl.obolibrary.org/obo/UBERON_0007307		
UBERON:0010948	biolink:AnatomicalEntity	cleidooccipital muscle	A muscle organ that attaches_to a clavicle and attaches_to a occipital bone.	NCIT:C52895|MA:0002276|EMAPA:37688	hp.json	cleido-occipitalis|cleido-occipitalis muscle|cleidooccipital	http://purl.obolibrary.org/obo/UBERON_0010948		
UBERON:0007306	biolink:AnatomicalEntity	pronephric glomerular capillary	A glomerular capillary that is part of a pronephros.	ZFA:0005309|TAO:0005309	hp.json		http://purl.obolibrary.org/obo/UBERON_0007306		
UBERON:0010949	biolink:AnatomicalEntity	sternooccipital muscle	A muscle organ that has_muscle_insertion a occipital bone and has_muscle_origin a sternum.	NCIT:C53069|EMAPA:37702|MA:0002385|UMLS:C1710196	hp.json	sternooccipital	http://purl.obolibrary.org/obo/UBERON_0010949		
UBERON:0007304	biolink:AnatomicalEntity	appendage vasculature	A vasculature that is part of a limb/fin.	ZFA:0005095|TAO:0005095	hp.json	fin vasculature	http://purl.obolibrary.org/obo/UBERON_0007304		
UBERON:0007303	biolink:AnatomicalEntity	pharyngeal vasculature	A vasculature that is part of a chordate pharynx.	TAO:0005003|ZFA:0005003	hp.json	branchial vasculature	http://purl.obolibrary.org/obo/UBERON_0007303		
UBERON:0007302	biolink:AnatomicalEntity	pectoral appendage vasculature	A vasculature that is part of a pectoral appendage.	ZFA:0005096|TAO:0005096	hp.json	pectoral fin vasculature	http://purl.obolibrary.org/obo/UBERON_0007302		
GO:0003278	biolink:BiologicalProcess	apoptotic process involved in heart morphogenesis	Any apoptotic process that contributes to the shaping of the heart.		hp.json	apoptosis involved in heart morphogenesis	http://purl.obolibrary.org/obo/GO_0003278		
GO:0003277	biolink:BiologicalProcess	apoptotic process involved in endocardial cushion morphogenesis	Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.		hp.json	apoptosis involved in endocardial cushion morphogenesis	http://purl.obolibrary.org/obo/GO_0003277		
GO:0003279	biolink:BiologicalProcess	cardiac septum development	The progression of a cardiac septum over time, from its initial formation to the mature structure.		hp.json	heart septum development	http://purl.obolibrary.org/obo/GO_0003279		
HP:0002539	biolink:PhenotypicFeature	Cortical dysplasia	The presence of developmental dysplasia of the cerebral cortex.	SNOMEDCT_US:253153000|UMLS:C0431380|MSH:D054220	hp.json	Neocortical dysplasia	http://purl.obolibrary.org/obo/HP_0002539		
GO:0003273	biolink:BiologicalProcess	cell migration involved in endocardial cushion formation	The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.		hp.json		http://purl.obolibrary.org/obo/GO_0003273		
GO:0003275	biolink:BiologicalProcess	apoptotic process involved in outflow tract morphogenesis	Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.		hp.json	apoptosis involved in outflow tract morphogenesis	http://purl.obolibrary.org/obo/GO_0003275		
HP:0002538	biolink:PhenotypicFeature	Abnormal cerebral cortex morphology	Any structural abnormality of the cerebral cortex.	UMLS:C4025701	hp.json	Abnormality of the cerebral cortex	http://purl.obolibrary.org/obo/HP_0002538		
GO:0003272	biolink:BiologicalProcess	endocardial cushion formation	The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.		hp.json		http://purl.obolibrary.org/obo/GO_0003272		
HP:0002530	biolink:PhenotypicFeature	Axial dystonia	A type of dystonia that affects the midline muscles, i.e., the chest, abdominal, and back muscles.	UMLS:C1836149	hp.json	Truncal dystonia	http://purl.obolibrary.org/obo/HP_0002530		
HP:0002536	biolink:PhenotypicFeature	Abnormal cortical gyration	An abnormality of the gyri (i.e., the ridges) of the cerebral cortex of the brain.	UMLS:C1856019	hp.json	Cerebral gyral anomalies|Gyral disorganization|Abnormal gyration	http://purl.obolibrary.org/obo/HP_0002536		
HP:0002533	biolink:PhenotypicFeature	Abnormal posturing	Involuntary flexion or extension of the arms and legs.	UMLS:C0231471|SNOMEDCT_US:43029002	hp.json		http://purl.obolibrary.org/obo/HP_0002533		
GO:0030890	biolink:BiologicalProcess	positive regulation of B cell proliferation	Any process that activates or increases the rate or extent of B cell proliferation.		hp.json	positive regulation of B-lymphocyte proliferation|upregulation of B cell proliferation|stimulation of B cell proliferation|up regulation of B cell proliferation|positive regulation of B-cell proliferation|positive regulation of B lymphocyte proliferation|activation of B cell proliferation|up-regulation of B cell proliferation	http://purl.obolibrary.org/obo/GO_0030890		
GO:0030888	biolink:BiologicalProcess	regulation of B cell proliferation	Any process that modulates the frequency, rate or extent of B cell proliferation.		hp.json	regulation of B-cell proliferation|regulation of B lymphocyte proliferation|regulation of B-lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0030888		
GO:0030889	biolink:BiologicalProcess	negative regulation of B cell proliferation	Any process that stops, prevents or reduces the rate or extent of B cell proliferation.		hp.json	negative regulation of B-lymphocyte proliferation|downregulation of B cell proliferation|down regulation of B cell proliferation|inhibition of B cell proliferation|down-regulation of B cell proliferation|negative regulation of B-cell proliferation|negative regulation of B lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0030889		
GO:0030886	biolink:BiologicalProcess	negative regulation of myeloid dendritic cell activation	Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.		hp.json	down-regulation of myeloid dendritic cell activation|down regulation of myeloid dendritic cell activation|inhibition of myeloid dendritic cell activation|downregulation of myeloid dendritic cell activation	http://purl.obolibrary.org/obo/GO_0030886		
GO:0030887	biolink:BiologicalProcess	positive regulation of myeloid dendritic cell activation	Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.		hp.json	up regulation of myeloid dendritic cell activation|activation of myeloid dendritic cell activation|stimulation of myeloid dendritic cell activation|upregulation of myeloid dendritic cell activation|up-regulation of myeloid dendritic cell activation	http://purl.obolibrary.org/obo/GO_0030887		
GO:0030885	biolink:BiologicalProcess	regulation of myeloid dendritic cell activation	Any process that modulates the frequency or rate of myeloid dendritic cell activation.		hp.json		http://purl.obolibrary.org/obo/GO_0030885		
HP:0002548	biolink:PhenotypicFeature	Parkinsonism with favorable response to dopaminergic medication	Parkinsonism is a clinical syndrome that is a feature of a number of different diseases, including Parkinson disease itself, other neurodegenerative diseases such as progressive supranuclear palsy, and as a side-effect of some neuroleptic medications. Some but not all individuals with Parkinsonism show responsiveness to dopaminergic medication defined as a substantial reduction of amelioration of the component signs of Parkinsonism (including mainly tremor, bradykinesia, rigidity, and postural instability) upon administration of dopaminergic medication.	UMLS:C1846868	hp.json	Favorable response to levodopa|Favourable response to levodopa|Parkinsonism with favourable response to dopaminergic medication	http://purl.obolibrary.org/obo/HP_0002548		
HP:0002549	biolink:PhenotypicFeature	Deficit in phonologic short-term memory	Impaired ability to repeat non-word sounds. The test for nonword repetition involves the repetition of nonsensical words of increasing length and complexity and is regarded as a measure of phonological (speech sound) processing and short-term memory	UMLS:C1847609	hp.json	Impaired non-word repetition|Deficit in non-word repetition	http://purl.obolibrary.org/obo/HP_0002549		
GO:0003281	biolink:BiologicalProcess	ventricular septum development	The progression of the ventricular septum over time from its formation to the mature structure.		hp.json	interventricular septum development|septum inferius development	http://purl.obolibrary.org/obo/GO_0003281		
GO:0003283	biolink:BiologicalProcess	atrial septum development	The progression of the atrial septum over time, from its initial formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0003283		
HP:0002542	biolink:PhenotypicFeature	Olivopontocerebellar atrophy	Neuronal degeneration in the cerebellum, pontine nuclei, and inferior olivary nucleus.	MSH:D009849|UMLS:C0028968|SNOMEDCT_US:67761004	hp.json	Olivopontocerebellar degeneration	http://purl.obolibrary.org/obo/HP_0002542		
HP:0002540	biolink:PhenotypicFeature	Inability to walk	Incapability to ambulate.	SNOMEDCT_US:282145008|UMLS:C0560046	hp.json	Non-ambulatory|Inability to walk	http://purl.obolibrary.org/obo/HP_0002540		
HP:0002546	biolink:PhenotypicFeature	Incomprehensible speech		UMLS:C1838027	hp.json	Incomprehensible speech	http://purl.obolibrary.org/obo/HP_0002546		
HP:0002544	biolink:PhenotypicFeature	Retrocollis	A form of torticollis in which the head is drawn back, either due to a permanent contractures of neck extensor muscles, or to a spasmodic contracture.	UMLS:C3887667	hp.json		http://purl.obolibrary.org/obo/HP_0002544		
HP:0002545	biolink:PhenotypicFeature	Patchy demyelination of subcortical white matter	Patchy loss of myelin from nerve fibers in the central nervous system.	UMLS:C1857638	hp.json		http://purl.obolibrary.org/obo/HP_0002545		
GO:0030879	biolink:BiologicalProcess	mammary gland development	The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.		hp.json	mammogenesis	http://purl.obolibrary.org/obo/GO_0030879		
HP:0002518	biolink:PhenotypicFeature	Abnormal periventricular white matter morphology	A structural abnormality of the myelinated axons (white matter) located near the cerebral ventricles.	UMLS:C2673431	hp.json	Periventricular white matter abnormalities|Abnormality of the periventricular white matter	http://purl.obolibrary.org/obo/HP_0002518		
HP:0002515	biolink:PhenotypicFeature	Waddling gait	Weakness of the hip girdle and upper thigh muscles, for instance in myopathies, leads to an instability of the pelvis on standing and walking. If the muscles extending the hip joint are affected, the posture in that joint becomes flexed and lumbar lordosis increases. The patients usually have difficulties standing up from a sitting position. Due to weakness in the gluteus medius muscle, the hip on the side of the swinging leg drops with each step (referred to as Trendelenburg sign). The gait appears waddling. The patients frequently attempt to counteract the dropping of the hip on the swinging side by bending the trunk towards the side which is in the stance phase (in the German language literature this is referred to as Duchenne sign). Similar gait patterns can be caused by orthopedic conditions when the origin and the insertion site of the gluteus medius muscle are closer to each other than normal, for instance due to a posttraumatic elevation of the trochanter or pseudarthrosis of the femoral neck.	SNOMEDCT_US:271706000|MSH:D020233|UMLS:C0231712	hp.json	Waddling gait|Waddling walk	http://purl.obolibrary.org/obo/HP_0002515		
HP:0002516	biolink:PhenotypicFeature	Increased intracranial pressure	An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid.	UMLS:C0151740|SNOMEDCT_US:271719001|MSH:D019586	hp.json	Pseudotumor cerebri|Rise in pressure inside skull|Intracranial hypertension|Intracranial pressure elevation	http://purl.obolibrary.org/obo/HP_0002516		
GO:0003253	biolink:BiologicalProcess	cardiac neural crest cell migration involved in outflow tract morphogenesis	The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.		hp.json		http://purl.obolibrary.org/obo/GO_0003253		
HP:0002519	biolink:PhenotypicFeature	Hypnagogic hallucinations	Fleeting perceptual experiences that occur during the transition from wakefulness to sleep.	MSH:D006212|UMLS:C0233773|SNOMEDCT_US:44780000	hp.json		http://purl.obolibrary.org/obo/HP_0002519		
HP:0002510	biolink:PhenotypicFeature	Spastic tetraplegia	Spastic paralysis affecting all four limbs.	UMLS:C0426970|MSH:D011782|SNOMEDCT_US:192965001	hp.json	Spastic quadriplegia	http://purl.obolibrary.org/obo/HP_0002510		
HP:0002514	biolink:PhenotypicFeature	Cerebral calcification	The presence of calcium deposition within brain structures.	SNOMEDCT_US:17944005|UMLS:C0270685	hp.json	Brain calcification|Intracerebral calcifications|Intracranial calcification|Abnormal deposits of calcium in the brain|Intracranial calcifications	http://purl.obolibrary.org/obo/HP_0002514		
HP:0002511	biolink:PhenotypicFeature	Alzheimer disease	A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads.	SNOMEDCT_US:230267005|UMLS:C0002395|MSH:C536595|MSH:D000544|MONDO:0004975|UMLS:C1863051|DOID:10652|SNOMEDCT_US:26929004	hp.json	Alzheimer disease|Late-onset form of familial Alzheimer disease	http://purl.obolibrary.org/obo/HP_0002511		
HP:0002512	biolink:PhenotypicFeature	Brain stem compression		UMLS:C0270680|SNOMEDCT_US:5582005|SNOMEDCT_US:25816005	hp.json		http://purl.obolibrary.org/obo/HP_0002512		
HP:0002528	biolink:PhenotypicFeature	Granulovacuolar degeneration	Electron-dense granules within double membrane-bound cytoplasmic vacuoles.	UMLS:C0333454|SNOMEDCT_US:90506004	hp.json		http://purl.obolibrary.org/obo/HP_0002528		
HP:0002529	biolink:PhenotypicFeature	Neuronal loss in central nervous system		UMLS:C1850496	hp.json	Loss of brain cells|Neuronal loss|Neuronal loss in CNS	http://purl.obolibrary.org/obo/HP_0002529		
HP:0002526	biolink:PhenotypicFeature	Deficit in nonword repetition	Impaired ability to repeat non-word sounds. Nonword repetition (NWR) is a measure of short-term phonological memory.	UMLS:C4025702	hp.json		http://purl.obolibrary.org/obo/HP_0002526		
HP:0002527	biolink:PhenotypicFeature	Falls		UMLS:C0085639|SNOMEDCT_US:161898004|SNOMEDCT_US:1912002	hp.json	Falls	http://purl.obolibrary.org/obo/HP_0002527		
GO:0003260	biolink:BiologicalProcess	cardioblast migration	The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.		hp.json		http://purl.obolibrary.org/obo/GO_0003260		
HP:0002521	biolink:PhenotypicFeature	Hypsarrhythmia	Hypsarrhythmia is abnormal interictal high amplitude waves and a background of irregular spikes. There is continuous (during wakefulness), high-amplitude (>200 Hz), generalized polymorphic slowing with no organized background and multifocal spikes demonstrated by electroencephalography (EEG).	UMLS:C0684276|SNOMEDCT_US:28055006|MSH:D013036	hp.json	Hypsarrhythmia by EEG	http://purl.obolibrary.org/obo/HP_0002521		
HP:0002524	biolink:PhenotypicFeature	Cataplexy	A sudden and transient episode of bilateral loss of muscle tone, often triggered by emotions.	MSH:D002385|SNOMEDCT_US:46263000|UMLS:C0007384	hp.json		http://purl.obolibrary.org/obo/HP_0002524		
HP:0002522	biolink:PhenotypicFeature	Areflexia of lower limbs	Inability to elicit tendon reflexes in the lower limbs.	UMLS:C1856694	hp.json	Absent lower limb tendon reflexes|Areflexia, lower limbs|Areflexia of the lower limbs|Areflexia in lower limbs	http://purl.obolibrary.org/obo/HP_0002522		
GO:0003238	biolink:BiologicalProcess	conus arteriosus development	The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.		hp.json		http://purl.obolibrary.org/obo/GO_0003238		
GO:0030857	biolink:BiologicalProcess	negative regulation of epithelial cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.		hp.json	inhibition of epithelial cell differentiation|downregulation of epithelial cell differentiation|down-regulation of epithelial cell differentiation|down regulation of epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0030857		
GO:0003237	biolink:BiologicalProcess	sinus venosus formation	The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003237		
GO:0030858	biolink:BiologicalProcess	positive regulation of epithelial cell differentiation	Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.		hp.json	up-regulation of epithelial cell differentiation|up regulation of epithelial cell differentiation|activation of epithelial cell differentiation|stimulation of epithelial cell differentiation|upregulation of epithelial cell differentiation	http://purl.obolibrary.org/obo/GO_0030858		
GO:0030855	biolink:BiologicalProcess	epithelial cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.		hp.json		http://purl.obolibrary.org/obo/GO_0030855		
GO:0003239	biolink:BiologicalProcess	conus arteriosus morphogenesis	The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.		hp.json		http://purl.obolibrary.org/obo/GO_0003239		
GO:0030856	biolink:BiologicalProcess	regulation of epithelial cell differentiation	Any process that modulates the frequency, rate or extent of epithelial cell differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0030856		
GO:0030853	biolink:BiologicalProcess	negative regulation of granulocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.		hp.json	inhibition of granulocyte differentiation|downregulation of granulocyte differentiation|down-regulation of granulocyte differentiation|down regulation of granulocyte differentiation	http://purl.obolibrary.org/obo/GO_0030853		
GO:0030854	biolink:BiologicalProcess	positive regulation of granulocyte differentiation	Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.		hp.json	up-regulation of granulocyte differentiation|up regulation of granulocyte differentiation|activation of granulocyte differentiation|stimulation of granulocyte differentiation|upregulation of granulocyte differentiation	http://purl.obolibrary.org/obo/GO_0030854		
GO:0003236	biolink:BiologicalProcess	sinus venosus morphogenesis	The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003236		
GO:0030851	biolink:BiologicalProcess	granulocyte differentiation	The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.		hp.json	granulocyte cell differentiation	http://purl.obolibrary.org/obo/GO_0030851		
GO:0030852	biolink:BiologicalProcess	regulation of granulocyte differentiation	Any process that modulates the frequency, rate or extent of granulocyte differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0030852		
GO:0003235	biolink:BiologicalProcess	sinus venosus development	The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003235		
GO:0003230	biolink:BiologicalProcess	cardiac atrium development	The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.		hp.json		http://purl.obolibrary.org/obo/GO_0003230		
GO:0003231	biolink:BiologicalProcess	cardiac ventricle development	The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003231		
HP:0002575	biolink:PhenotypicFeature	Tracheoesophageal fistula	An abnormal connection (fistula) between the esophagus and the trachea.	SNOMEDCT_US:95435007|UMLS:C0040588|MSH:D014138|MEDDRA:10044310|Fyler:4202	hp.json	Abnormal connection between trachea and oesophagus|Abnormal connection between trachea and esophagus	http://purl.obolibrary.org/obo/HP_0002575		hposlim_core
HP:0002576	biolink:PhenotypicFeature	Intussusception	An abnormality of the intestine in which part of the intestine invaginates (telescopes) into another part of the intestine.	UMLS:C0021933|MSH:D007443|MEDDRA:10022863|SNOMEDCT_US:49723003|SNOMEDCT_US:35327006	hp.json		http://purl.obolibrary.org/obo/HP_0002576		hposlim_core
HP:0002573	biolink:PhenotypicFeature	Hematochezia	The passage of fresh (red) blood per anus, usually in or with stools. Most rectal bleeding comes from the colon, rectum, or anus.	SNOMEDCT_US:236068001|SNOMEDCT_US:405729008|UMLS:C0018932|MSH:D006471	hp.json	Rectal bleeding|Recurrent rectal bleeding	http://purl.obolibrary.org/obo/HP_0002573		
UBERON:0009911	biolink:AnatomicalEntity	lobule		FMA:45737|NCIT:C12990|UMLS:C0921005	hp.json	lobulus	http://purl.obolibrary.org/obo/UBERON_0009911		upper_level
HP:0002574	biolink:PhenotypicFeature	Episodic abdominal pain	An intermittent form of abdominal pain.	UMLS:C3808022|UMLS:C0262527	hp.json	Intermittent abdominal pain	http://purl.obolibrary.org/obo/HP_0002574		
UBERON:0009912	biolink:AnatomicalEntity	anatomical lobe	A portion of an organ, such as the liver, lung, breast, or brain.	FMA:45728|NCIT:C13393	hp.json	lobus	http://purl.obolibrary.org/obo/UBERON_0009912		upper_level
UBERON:0009913	biolink:AnatomicalEntity	renal lobe	The portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it[MP]. It is composed of many renal lobules[WP].	FMA:17881|NCIT:C32894|UMLS:C0736382	hp.json	lobus renalis|lobi renalis|lobi renales|kidney lobe	http://purl.obolibrary.org/obo/UBERON_0009913		pheno_slim
HP:0002579	biolink:PhenotypicFeature	Gastrointestinal dysmotility	Abnormal intestinal contractions, such as spasms and intestinal paralysis, related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes.	UMLS:C1836923	hp.json	GI dysmotility	http://purl.obolibrary.org/obo/HP_0002579		hposlim_core
UBERON:0009914	biolink:AnatomicalEntity	renal lobule	The portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys.	FMA:17670	hp.json	renunculus|kidney lobule|renal cortical lobule|cortical lobule of kidney|cortical lobule|lobuli corticales renis|renculus|reniculus|lobulus corticalis renalis|lobulus renalis	http://purl.obolibrary.org/obo/UBERON_0009914		pheno_slim
HP:0002577	biolink:PhenotypicFeature	Abnormal stomach morphology	An abnormality of the stomach.	UMLS:C4025699	hp.json	Abnormality of the stomach	http://purl.obolibrary.org/obo/HP_0002577		
HP:0002578	biolink:PhenotypicFeature	Gastroparesis	Decreased strength of the muscle layer of stomach, which leads to a decreased ability to empty the contents of the stomach despite the absence of obstruction.	SNOMEDCT_US:235675006|MSH:D018589|SNOMEDCT_US:196753007|UMLS:C0152020	hp.json	Delayed gastric emptying	http://purl.obolibrary.org/obo/HP_0002578		hposlim_core
UBERON:0009916	biolink:AnatomicalEntity	wall of ureter	An anatomical wall that is part of a ureter.	FMA:15888	hp.json	ureteral wall	http://purl.obolibrary.org/obo/UBERON_0009916		
HP:0002571	biolink:PhenotypicFeature	Achalasia	A disorder of esophageal motility characterized by the inability of the lower esophageal sphincter to relax during swallowing and by inadequate or lacking peristalsis in the lower half of the body of the esophagus.	UMLS:C0014848|MSH:D004931|MEDDRA:10030136|SNOMEDCT_US:45564002	hp.json	Achalasia of the oesophagus|Achalasia of the esophagus	http://purl.obolibrary.org/obo/HP_0002571		hposlim_core
HP:0002572	biolink:PhenotypicFeature	Episodic vomiting	Paroxysmal, recurrent episodes of vomiting.	UMLS:C1838993|UMLS:C1857202	hp.json	Frequent vomiting|Episodic vomiting	http://purl.obolibrary.org/obo/HP_0002572		
HP:0002570	biolink:PhenotypicFeature	Steatorrhea	Greater than normal amounts of fat in the feces. This is a result of malabsorption of lipids in the small intestine and results in frothy foul-smelling fecal matter that floats.	UMLS:C0038238|SNOMEDCT_US:66187002|SNOMEDCT_US:27868004|MSH:D045602	hp.json	Greasy stools|Fat in faeces|Fatty stool|Fat in feces	http://purl.obolibrary.org/obo/HP_0002570		
GO:0003248	biolink:BiologicalProcess	heart capillary growth	The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.		hp.json		http://purl.obolibrary.org/obo/GO_0003248		
GO:0003245	biolink:BiologicalProcess	cardiac muscle tissue growth involved in heart morphogenesis	The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003245		
GO:0003241	biolink:BiologicalProcess	growth involved in heart morphogenesis	Developmental growth that contributes to the shaping of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003241		
GO:0003240	biolink:BiologicalProcess	conus arteriosus formation	The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.		hp.json		http://purl.obolibrary.org/obo/GO_0003240		
HP:0002586	biolink:PhenotypicFeature	Peritonitis	Inflammation of the peritoneum.	UMLS:C0031154|SNOMEDCT_US:48661000|MSH:D010538	hp.json	Inflammation of the peritoneum	http://purl.obolibrary.org/obo/HP_0002586		
HP:0002587	biolink:PhenotypicFeature	Projectile vomiting	Vomiting that ejects the gastric contents with great force.	SNOMEDCT_US:8579004|UMLS:C0221151	hp.json	Projectile vomiting	http://purl.obolibrary.org/obo/HP_0002587		
HP:0002584	biolink:PhenotypicFeature	Intestinal bleeding	Bleeding from the intestines.	SNOMEDCT_US:712510007|UMLS:C0267373	hp.json	Intestinal hemorrhage|Intestinal haemorrhage|Intestinal bleeding	http://purl.obolibrary.org/obo/HP_0002584		
HP:0002585	biolink:PhenotypicFeature	Abnormality of the peritoneum	An abnormality of the peritoneum.	UMLS:C4025698	hp.json		http://purl.obolibrary.org/obo/HP_0002585		
HP:0002588	biolink:PhenotypicFeature	Duodenal ulcer	An erosion of the mucous membrane in a portion of the duodenum.	SNOMEDCT_US:51868009|SNOMEDCT_US:367474008|MEDDRA:10013836|MSH:D004381|UMLS:C0013295	hp.json		http://purl.obolibrary.org/obo/HP_0002588		hposlim_core
HP:0002589	biolink:PhenotypicFeature	Gastrointestinal atresia		UMLS:C4025697	hp.json	GI atresia	http://purl.obolibrary.org/obo/HP_0002589		
HP:0002582	biolink:PhenotypicFeature	Atrophic gastritis	Atrophic gastritis (AG) is a histopathological entity that is characterized by chronic inflammation of the gastric mucosa with loss of gastric glandular cells and replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue.	SNOMEDCT_US:84568007|UMLS:C0017154|MSH:D005757	hp.json	Chronic atrophic gastritis	http://purl.obolibrary.org/obo/HP_0002582		
HP:0002583	biolink:PhenotypicFeature	Colitis	Colitis refers to an inflammation of the colon and is often used to describe an inflammation of the large intestine (colon, cecum and rectum). Colitides may be acute and self-limited or chronic, and broadly fit into the category of digestive diseases.	UMLS:C0009319|SNOMEDCT_US:64226004|MSH:D003092	hp.json		http://purl.obolibrary.org/obo/HP_0002583		
HP:0002580	biolink:PhenotypicFeature	Volvulus	Abnormal twisting of a portion of intestine around itself or around a stalk of mesentery tissue.	UMLS:C0042961|SNOMEDCT_US:9707006|SNOMEDCT_US:90738007|MSH:D045822	hp.json		http://purl.obolibrary.org/obo/HP_0002580		
GO:0003216	biolink:BiologicalProcess	cardiac left atrium formation	The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.		hp.json		http://purl.obolibrary.org/obo/GO_0003216		
GO:0005879	biolink:CellularComponent	axonemal microtubule	A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.		hp.json		http://purl.obolibrary.org/obo/GO_0005879		
GO:0003215	biolink:BiologicalProcess	cardiac right ventricle morphogenesis	The process in which the right cardiac ventricle is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0003215		
GO:0003218	biolink:BiologicalProcess	cardiac left ventricle formation	The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.		hp.json		http://purl.obolibrary.org/obo/GO_0003218		
GO:0003217	biolink:BiologicalProcess	cardiac right atrium formation	The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.		hp.json		http://purl.obolibrary.org/obo/GO_0003217		
GO:0003212	biolink:BiologicalProcess	cardiac left atrium morphogenesis	The process in which the left cardiac atrium is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0003212		
GO:0003211	biolink:BiologicalProcess	cardiac ventricle formation	The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003211		
GO:0003214	biolink:BiologicalProcess	cardiac left ventricle morphogenesis	The process in which the left cardiac ventricle is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0003214		
GO:0005874	biolink:CellularComponent	microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.	Wikipedia:Microtubule|NIF_Subcellular:sao1846835077	hp.json	neurotubule|microtubuli|microtubulus	http://purl.obolibrary.org/obo/GO_0005874		goslim_metagenomics
GO:0003213	biolink:BiologicalProcess	cardiac right atrium morphogenesis	The process in which the right cardiac atrium is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0003213		
GO:0003210	biolink:BiologicalProcess	cardiac atrium formation	The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.		hp.json		http://purl.obolibrary.org/obo/GO_0003210		
HP:0002553	biolink:PhenotypicFeature	Highly arched eyebrow	Increased height of the central portion of the eyebrow, forming a crescent, semicircular, or inverted U shape.	UMLS:C1868571|UMLS:C4020849	hp.json	Highly arched eyebrow|Broad, arched eyebrows|High arched eyebrows|High-arched eyebrows|Bowed and upward slanting eyebrows|Arched eyebrows|Thick, flared eyebrows|High, rounded eyebrows	http://purl.obolibrary.org/obo/HP_0002553		hposlim_core
HP:0002552	biolink:PhenotypicFeature	Trichodysplasia	Developmental dysplasia of the hair.	UMLS:C4020850|UMLS:C4025700	hp.json	Generalised trichodysplasia|Generalized trichodysplasia	http://purl.obolibrary.org/obo/HP_0002552		
HP:0002557	biolink:PhenotypicFeature	Hypoplastic nipples	Underdevelopment of the nipple.	SNOMEDCT_US:268290005|UMLS:C0432355	hp.json	Nipple hypoplasia|Small nipples	http://purl.obolibrary.org/obo/HP_0002557		
HP:0002558	biolink:PhenotypicFeature	Supernumerary nipple	Presence of more than two nipples.	UMLS:C0266011|Fyler:4234|MSH:C562557|SNOMEDCT_US:50956007	hp.json	Accessory nipple|accessory mamilla|Accessory nipples|Increased nipple number|accessory mamillas|Supernumerary nipples	http://purl.obolibrary.org/obo/HP_0002558		hposlim_core
HP:0002555	biolink:PhenotypicFeature	Absent pubic hair	Absence of pubic hair.	UMLS:C1859391	hp.json	Absent pubic hair	http://purl.obolibrary.org/obo/HP_0002555		hposlim_core
HP:0002550	biolink:PhenotypicFeature	Absent facial hair	Absence of facial hair.	UMLS:C1848192	hp.json	Absent facial hair	http://purl.obolibrary.org/obo/HP_0002550		
GO:0003219	biolink:BiologicalProcess	cardiac right ventricle formation	The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.		hp.json		http://purl.obolibrary.org/obo/GO_0003219		
GO:0003229	biolink:BiologicalProcess	ventricular cardiac muscle tissue development	The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.		hp.json	ventricular myocardium development	http://purl.obolibrary.org/obo/GO_0003229		
GO:0003228	biolink:BiologicalProcess	atrial cardiac muscle tissue development	The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.		hp.json	atrial myocardium development	http://purl.obolibrary.org/obo/GO_0003228		
GO:0005886	biolink:CellularComponent	plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	Wikipedia:Cell_membrane|NIF_Subcellular:sao1663586795	hp.json	bacterial inner membrane|cytoplasmic membrane|plasma membrane lipid bilayer|cellular membrane|plasmalemma|juxtamembrane|inner endospore membrane|cell membrane	http://purl.obolibrary.org/obo/GO_0005886		goslim_generic|goslim_agr|goslim_candida|goslim_yeast|prokaryote_subset|goslim_plant|goslim_drosophila|goslim_chembl|goslim_metagenomics|goslim_aspergillus|goslim_mouse
GO:0005884	biolink:NamedThing	actin filament			hp.json		http://purl.obolibrary.org/obo/GO_0005884		
GO:0005882	biolink:NamedThing	intermediate filament			hp.json		http://purl.obolibrary.org/obo/GO_0005882		
GO:0005880	biolink:CellularComponent	nuclear microtubule	Any microtubule in the nucleus of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0005880		
GO:0003221	biolink:BiologicalProcess	right ventricular cardiac muscle tissue morphogenesis	The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.		hp.json	right ventricle myocardium morphogenesis	http://purl.obolibrary.org/obo/GO_0003221		
GO:0003220	biolink:BiologicalProcess	left ventricular cardiac muscle tissue morphogenesis	The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.		hp.json	left ventricular myocardium morphogenesis	http://purl.obolibrary.org/obo/GO_0003220		
GO:0005881	biolink:CellularComponent	cytoplasmic microtubule	Any microtubule in the cytoplasm of a cell.		hp.json	non-spindle-associated astral microtubule	http://purl.obolibrary.org/obo/GO_0005881		
HP:0002564	biolink:PhenotypicFeature	obsolete Malformation of the heart and great vessels			hp.json		http://purl.obolibrary.org/obo/HP_0002564		
HP:0002562	biolink:PhenotypicFeature	Low-set nipples	Placement of the nipples at a lower than normal location.	UMLS:C1836933	hp.json	Low-set nipples	http://purl.obolibrary.org/obo/HP_0002562		hposlim_core
HP:0002563	biolink:PhenotypicFeature	Constrictive pericarditis	Presence of a thickened, fibrotic pericardium that forms a non-compliant shell around the heart, and resulting from chronic inflammation of the pericardium.	UMLS:C0031048|MSH:D010494|SNOMEDCT_US:85598007	hp.json		http://purl.obolibrary.org/obo/HP_0002563		
HP:0002566	biolink:PhenotypicFeature	Intestinal malrotation	An abnormality of the intestinal rotation and fixation that normally occurs during the development of the gut. This can lead to volvulus, or twisting of the intestine that causes obstruction and necrosis.	SNOMEDCT_US:253789002|MSH:C562456|SNOMEDCT_US:29980002|SNOMEDCT_US:48641006|UMLS:C0221210|MEDDRA:10064024	hp.json	Malrotation|Gut malrotation	http://purl.obolibrary.org/obo/HP_0002566		hposlim_core
HP:0002561	biolink:PhenotypicFeature	Absent nipple	Congenital failure to develop, and absence of, the nipple.	SNOMEDCT_US:248820000|UMLS:C0425795	hp.json	Athelia|Absent nipple|Absent nipples	http://purl.obolibrary.org/obo/HP_0002561		
CL:1000692	biolink:Cell	kidney interstitial fibroblast		KUPO:0001102	hp.json		http://purl.obolibrary.org/obo/CL_1000692		
HP:0002705	biolink:PhenotypicFeature	High, narrow palate	The presence of a high and narrow palate.	UMLS:C1837404	hp.json	Narrow, highly arched roof of mouth|Gothic palate|Narrow, high-arched palate|Narrow, high-arched roof of mouth|Narrow and high arched palate|Narrow, highly arched palate|High narrow palate|High vaulted palate|High, narrow palate	http://purl.obolibrary.org/obo/HP_0002705		
HP:0002703	biolink:PhenotypicFeature	Abnormality of skull ossification	An abnormality of the process of ossification of the skull.	UMLS:C4280553|UMLS:C4280552|UMLS:C4280551|UMLS:C4280550|UMLS:C4025686	hp.json	Abnormality of bone mineralization of cranium|Abnormality of bone calcification of calvarium|Abnormality of bone calcification of cranium|Abnormality of skull bone formation|Abnormality of bone mineralization of skull|Abnormality of bone formation of calvarium|Abnormality of ossification of calvarium|Abnormality of ossification of cranium|Abnormality of bone calcification of skull|Abnormality of bone mineralization of calvarium|Abnormality of bone formation of cranium	http://purl.obolibrary.org/obo/HP_0002703		
HP:0002708	biolink:PhenotypicFeature	Prominent median palatal raphe	Unusual prominence of the median palatal raphe, which is the ridge formed by the fusion of the two plates of the skull that form the hard palate.	UMLS:C1845108	hp.json	Prominent central ridge on roof of the mouth|Prominent central palatal ridge|Prominent medial palatal suture	http://purl.obolibrary.org/obo/HP_0002708		
HP:0002707	biolink:PhenotypicFeature	Palate telangiectasia	The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the palate.	UMLS:C4280267|UMLS:C1857699	hp.json	Palatal telangiectasia|Palate telangiectases|Telangiectasia of the roof of the mouth|Palate teleangiectases|Spider veins of the roof of the mouth|Palatal angioectasia|Palatal spider veins	http://purl.obolibrary.org/obo/HP_0002707		
HP:0002700	biolink:PhenotypicFeature	Large foramen magnum	An abnormal increase in the size of the foramen magnum.	UMLS:C4280555|UMLS:C4280554|UMLS:C1844508|UMLS:C4073291	hp.json	Increased diameter of foramen magnum|Dilation of foramen magnum|Enlarged foramen magnum|Increased circumference of foramen magnum|Big foramen magnum|Wide foramen magnum	http://purl.obolibrary.org/obo/HP_0002700		hposlim_core
HP:0002737	biolink:PhenotypicFeature	Thick skull base		UMLS:C1839507	hp.json	Thick skull base|Increased thickness of skull base|Increased thickness of bone of skull base	http://purl.obolibrary.org/obo/HP_0002737		
HP:0002738	biolink:PhenotypicFeature	Hypoplastic frontal sinuses	Underdevelopment of frontal sinus.	UMLS:C1859682|UMLS:C4280549|UMLS:C4280548	hp.json	Decreased pneumatization of frontal sinus|Decreased volume of frontal sinuses|Hypotrophic frontal sinus|Underdeveloped frontal sinuses|Small frontal sinuses	http://purl.obolibrary.org/obo/HP_0002738		
HP:0002730	biolink:PhenotypicFeature	Chronic noninfectious lymphadenopathy	A chronic form of lymphadenopathy that is not related to infection.	UMLS:C1858970	hp.json		http://purl.obolibrary.org/obo/HP_0002730		
HP:0002733	biolink:PhenotypicFeature	Abnormality of the lymph nodes	A lymph node abnormality.	UMLS:C0149727	hp.json	Abnormality of the lymph nodes|Abnormal lymph node histology	http://purl.obolibrary.org/obo/HP_0002733		
HP:0002731	biolink:PhenotypicFeature	Decreased lymphocyte apoptosis	A reduction in the rate of apoptosis in lymphocytes.	UMLS:C1858969	hp.json	Defective lymphocyte apoptosis	http://purl.obolibrary.org/obo/HP_0002731		
HP:0002732	biolink:PhenotypicFeature	Lymph node hypoplasia	Underdevelopment of the lymph nodes.	UMLS:C4025683|UMLS:C1865377	hp.json	Small lymph nodes	http://purl.obolibrary.org/obo/HP_0002732		
HP:0002748	biolink:PhenotypicFeature	Rickets	Rickets is divided into two major categories including calcipenic and phosphopenic. Hypophosphatemia is described as a common manifestation of both categories. Hypophosphatemic rickets is the most common type of rickets that is characterized by low levels of serum phosphate, resistance to ultraviolet radiation or vitamin D intake. There are several issues involved in hypophosphatemic rickets such as calcium, vitamin D, phosphorus deficiencies. Moreover, other disorder can be associated with its occurrence such as absorption defects due to pancreatic, intestinal, gastric, and renal disorders and hepatobiliary disease. Symptoms are usually seen in childhood and can be varied in severity. Severe forms may be linked to bowing of the legs, poor bone growth, and short stature as well as joint and bone pain. Hypophosphatemic rickets are associated with renal excretion of phosphate, hypophosphatemia, and mineral defects in bones. The familial type of the disease is the most common type of rickets.	SNOMEDCT_US:41345002|MSH:D012279|UMLS:C0035579	hp.json	Weak and soft bones	http://purl.obolibrary.org/obo/HP_0002748		
HP:0002749	biolink:PhenotypicFeature	Osteomalacia	Osteomalacia is a general term for bone weakness owing to a defect in mineralization of the protein framework known as osteoid. This defective mineralization is mainly caused by lack in vitamin D. Osteomalacia in children is known as rickets.	UMLS:C0029442|SNOMEDCT_US:4598005	hp.json	Softening of the bones	http://purl.obolibrary.org/obo/HP_0002749		
HP:0002747	biolink:PhenotypicFeature	Respiratory insufficiency due to muscle weakness		UMLS:C3806467	hp.json	Respiratory failure due to muscle weakness|Decreased respiratory function due to muscle weakness|Decreased lung function due to weak breathing muscles|Respiratory muscle weakness|Respiratory distress due to muscle weakness	http://purl.obolibrary.org/obo/HP_0002747		
HP:0002740	biolink:PhenotypicFeature	Recurrent E. coli infections	Increased susceptibility to infections with Escherichia coli, as manifested by recurrent episodes of infection with this agent.	UMLS:C0014836|MSH:D004927|SNOMEDCT_US:71057007	hp.json	E coli infections|E coli infections, recurrent	http://purl.obolibrary.org/obo/HP_0002740		
HP:0002741	biolink:PhenotypicFeature	Recurrent Serratia marcescens infections	Increased susceptibility to Serratia marcescens infections, as manifested by recurrent episodes of Serratia marcescens infection.	UMLS:C4025682	hp.json		http://purl.obolibrary.org/obo/HP_0002741		
HP:0002744	biolink:PhenotypicFeature	Bilateral cleft lip and palate	Cleft lip and cleft palate affecting both sides of the face.	SNOMEDCT_US:1085331000119107|UMLS:C1398522	hp.json	Bilateral cleft lip and cleft palate|Right and left cleft lip and palate	http://purl.obolibrary.org/obo/HP_0002744		
HP:0002745	biolink:PhenotypicFeature	Oral leukoplakia	A thickened white patch on the oral mucosa that cannot be rubbed off.	UMLS:C0023532|SNOMEDCT_US:414603003|MSH:D007972|MSH:D007971|SNOMEDCT_US:9187004|UMLS:C1704317	hp.json	Oral white plaque|Oral leucoplakia|Oral leukoplasia|Oral idiopathic white patch|Oral idiopathic leukoplakia|leukokeratosis|Oral white patch|Oral idiopathic keratosis|Oral leukokeratosis	http://purl.obolibrary.org/obo/HP_0002745		hposlim_core
HP:0002742	biolink:PhenotypicFeature	Recurrent Klebsiella infections	Increased susceptibility to Klebsiella infections, as manifested by recurrent episodes of Klebsiella infection.	UMLS:C4021751	hp.json	Klebsiella infections, recurrent	http://purl.obolibrary.org/obo/HP_0002742		
HP:0002743	biolink:PhenotypicFeature	Recurrent enteroviral infections	Increased susceptibility to enteroviral infections, as manifested by recurrent episodes of enteroviral infection.	UMLS:C4025681	hp.json		http://purl.obolibrary.org/obo/HP_0002743		
HP:0002715	biolink:PhenotypicFeature	Abnormality of the immune system	An abnormality of the immune system.	UMLS:C4021753	hp.json	Immunological abnormality|Abnormality of the immune system	http://purl.obolibrary.org/obo/HP_0002715		
HP:0002716	biolink:PhenotypicFeature	Lymphadenopathy	Enlargment (swelling) of a lymph node.	UMLS:C0497156|MSH:D000072281|SNOMEDCT_US:30746006	hp.json	Swollen lymph nodes|Lymph node hyperplasia	http://purl.obolibrary.org/obo/HP_0002716		
HP:0002714	biolink:PhenotypicFeature	Downturned corners of mouth	A morphological abnormality of the mouth in which the angle of the mouth is downturned. The oral commissures are positioned inferior to the midline labial fissure.	UMLS:C1866195	hp.json	Downturned corners of mouth|Downturned mouth|Downturned oral commisures|Downturned corners of the mouth	http://purl.obolibrary.org/obo/HP_0002714		hposlim_core
HP:0002719	biolink:PhenotypicFeature	Recurrent infections	Increased susceptibility to infections.	UMLS:C0239998	hp.json	Susceptibility to infection|Frequent infections|infections, recurrent|Increased frequency of infection|Recurrent infections|Frequent, severe infections|Predisposition to infections	http://purl.obolibrary.org/obo/HP_0002719		
HP:0002717	biolink:PhenotypicFeature	Adrenal overactivity		UMLS:C4025685	hp.json		http://purl.obolibrary.org/obo/HP_0002717		
HP:0002718	biolink:PhenotypicFeature	Recurrent bacterial infections	Increased susceptibility to bacterial infections, as manifested by recurrent episodes of bacterial infection.	UMLS:C4020846|SNOMEDCT_US:428875002|UMLS:C1844383|UMLS:C2748958	hp.json	Frequent pyogenic infections|Recurrent bacterial infections|Susceptibility to pyogenic infection|Prone to bacterial infection|Frequent bacterial infections|Recurrent pyogenic infections|Recurrent major bacterial infections|Bacterial infections, recurrent|Increased susceptibility to bacterial infections	http://purl.obolibrary.org/obo/HP_0002718		
HP:0002711	biolink:PhenotypicFeature	Exaggerated median tongue furrow	Increased depth of the median tongue furrow.	UMLS:C1845109	hp.json	Deep central lingual furrow|Deep central lingual groove|Deep central tongue furrow|Deep median tongue groove|Deep central tongue groove|Deep median lingual groove|Deep median tongue furrow|Exaggerated median lingual furrow|Deep median lingual furrow	http://purl.obolibrary.org/obo/HP_0002711		
HP:0002710	biolink:PhenotypicFeature	Commissural lip pit	A depression located at an oral commissure.	UMLS:C0399605	hp.json	Commissural pit|Commissural labial pits|Lip pits at corners of the mouth|Pits at the corners of the lips	http://purl.obolibrary.org/obo/HP_0002710		hposlim_core
HP:0002726	biolink:PhenotypicFeature	Recurrent Staphylococcus aureus infections	Increased susceptibility to Staphylococcus aureus infections, as manifested by recurrent episodes of Staphylococcus aureus infection.	UMLS:C2673462	hp.json	Staphylococcus aureus infections, recurrent	http://purl.obolibrary.org/obo/HP_0002726		
HP:0002724	biolink:PhenotypicFeature	Recurrent Aspergillus infections	An increased susceptibility to Aspergillus infections, as manifested by a history of recurrent episodes of Aspergillus infections.	UMLS:C4021752	hp.json	Aspergillus infections, recurrent	http://purl.obolibrary.org/obo/HP_0002724		
HP:0002725	biolink:PhenotypicFeature	Systemic lupus erythematosus	A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes.	UMLS:C0024141|SNOMEDCT_US:55464009|MSH:D008180	hp.json	SLE	http://purl.obolibrary.org/obo/HP_0002725		
HP:0002728	biolink:PhenotypicFeature	Chronic mucocutaneous candidiasis	Recurrent or persistent superficial Candida infections of the skin, mucous membranes, and nails.	SNOMEDCT_US:234568006|MSH:D002178|UMLS:C0006845	hp.json	Mucocutaneous candidiasis|Chronic candidiasis of mucosa, skin and nails	http://purl.obolibrary.org/obo/HP_0002728		
HP:0002729	biolink:PhenotypicFeature	Follicular hyperplasia	Lymphadenopathy (enlargement of lymph nodes) owing to hyperplasia of follicular (germinal) centers.	UMLS:C4014733	hp.json		http://purl.obolibrary.org/obo/HP_0002729		
HP:0002722	biolink:PhenotypicFeature	Recurrent abscess formation	An increased susceptibility to abscess formation, as manifested by a medical history of recurrent abscesses.	UMLS:C4025684	hp.json		http://purl.obolibrary.org/obo/HP_0002722		
HP:0002723	biolink:PhenotypicFeature	Absence of bactericidal oxidative respiratory burst in phagocytes	An absence of the phase of elevated metabolic activity, during which oxygen consumption increases, that occurs in neutrophils, monocytes, and macrophages shortly after phagocytosing material. An enhanced uptake of oxygen leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, which play a part in microbiocidal activity.	UMLS:C1844385	hp.json		http://purl.obolibrary.org/obo/HP_0002723		
HP:0002720	biolink:PhenotypicFeature	Decreased circulating IgA level	Decreased levels of immunoglobulin A (IgA).	SNOMEDCT_US:29260007|MSH:D017098|UMLS:C0162538	hp.json	Gamma-A globulin deficiency|Reduced IgA levels|Decreased immunoglobulin A|Decreased IgA|Low levels of immunoglobulin A|IgA deficiency	http://purl.obolibrary.org/obo/HP_0002720		
HP:0002721	biolink:PhenotypicFeature	Immunodeficiency	Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.	MSH:D007153|SNOMEDCT_US:234532001|UMLS:C0021051	hp.json	Decreased immune function|Immune deficiency	http://purl.obolibrary.org/obo/HP_0002721		
UBERON:0034994	biolink:AnatomicalEntity	hindbrain cortical intermediate zone		EMAPA:32917|DHBA:12682	hp.json	hindbrain mantle layer	http://purl.obolibrary.org/obo/UBERON_0034994		
UBERON:0034995	biolink:AnatomicalEntity	jaw mesenchyme	Mesenchyme that is part of a developing jaw [Automatically generated definition].	EMAPA:32907|EMAPA:35454	hp.json		http://purl.obolibrary.org/obo/UBERON_0034995		
UBERON:0007376	biolink:AnatomicalEntity	outer epithelium	The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO].	FBbt:00004993|BTO:0000313|WBbt:0005733|Wikipedia:Epidermis_(zoology)|BSA:0000073|HAO:0000298|TADS:0000109	hp.json	epidermis|hypodermis|outer epithelial layer|outer epidermal layer|hypoderm|epidermis (sensu Metazoa)	http://purl.obolibrary.org/obo/UBERON_0007376		grouping_class
UBERON:0007375	biolink:AnatomicalEntity	roof of mouth	A multi-tissue structure consisting of bone and soft tissue that forms a part of the roof of the oral cavity. In mammals this is the combination of the primary palate (premaxilla) and the secondary palate. In early tetrapods it consists of the vomer, pterygoid, parasphenoid, palatine and ectopterygoid bones.	CALOHA:TS-2212	hp.json	roof of buccal cavity|roof of oral cavity|palatum|palate|primary or secondary palate	http://purl.obolibrary.org/obo/UBERON_0007375		grouping_class
UBERON:0007374	biolink:AnatomicalEntity	incus cartilage element	An incus endochondral element that is composed primarily of cartilage tissue.	EMAPA:18228	hp.json		http://purl.obolibrary.org/obo/UBERON_0007374		
UBERON:0007373	biolink:AnatomicalEntity	inferior surface of tongue	The lower (inferior) side of the tongue.	FMA:54648	hp.json	ventral surface of tongue|ventrum linguae	http://purl.obolibrary.org/obo/UBERON_0007373		
UBERON:0007371	biolink:AnatomicalEntity	superior surface of tongue	The upper (superior) side of the tongue.	FMA:54646	hp.json	dorsal surface of tongue	http://purl.obolibrary.org/obo/UBERON_0007371		
UBERON:0020358	biolink:AnatomicalEntity	accessory XI nerve nucleus	The spinal accessory nucleus lies within the cervical spinal cord (C1-C5) in the ventral horn. The nucleus ambiguus is classically said to provide the 'cranial component' of the accessory nerve. However, the very existence of this cranial component has been recently questioned and seen as contributing exclusively to the vagus nerve. The terminology continues to be used in describing both human anatomy, and that of other animals.	EMAPA:37067|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2003|FMA:83965|MA:0001033|Wikipedia:Spinal_accessory_nucleus	hp.json	accessory nucleus of anterior column of spinal cord|accessory neural nucleus|nucleus of the spinal accessory nerve|spinal accessory nucleus|spinal accessory nucleus|nucleus of the accessory nerve|nucleus of accessory nerve|nucleus nervi accessorii|nucleus accessorius columnae anterioris medullae spinalis	http://purl.obolibrary.org/obo/UBERON_0020358		
UBERON:0007367	biolink:AnatomicalEntity	surface of tongue	An anatomical surface that is part of a tongue.	FMA:54647|SCTID:314870004	hp.json	tongue surface	http://purl.obolibrary.org/obo/UBERON_0007367		
CHEBI:32952	biolink:ChemicalSubstance	amine	A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.	KEGG:C00706	hp.json	Substituted amine|Amin|amines|Amine	http://purl.obolibrary.org/obo/CHEBI_32952		3_STAR
PR:000002062	biolink:Protein	macrophage colony-stimulating factor 1 receptor	A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human CSF1R gene or a 1:1 ortholog thereof.	PIRSF:PIRSF500947|IUPHARobj:1806	hp.json	M-CSF-R|CSF-1R|CSF1R|proto-oncogene c-Fms|CD115|CSF-1 receptor|FMS|Csfmr|CSF-1-R	http://purl.obolibrary.org/obo/PR_000002062		
CHEBI:32926	biolink:ChemicalSubstance	octadecane	A straight-chain alkane carrying 18 carbon atoms.	KNApSAcK:C00030879|CAS:593-45-3|Gmelin:263389|Reaxys:1740138|Beilstein:1740138|CAS:593-45-3|PMID:9842728	hp.json	octadecane|CH3-[CH2]16-CH3|Oktadekan|n-octadecane	http://purl.obolibrary.org/obo/CHEBI_32926		3_STAR
UBERON:0007355	biolink:AnatomicalEntity	bony part of pharyngotympanic tube	The bony part of pharyngotympanic tube is about 12 mm. in length. It begins in the carotid wall of the tympanic cavity, below the septum canalis musculotubarii, and, gradually narrowing, ends at the angle of junction of the squama and the petrous portion of the temporal bone, its extremity presenting a jagged margin which serves for the attachment of the cartilaginous portion.	FMA:60057	hp.json	bony part of auditory tube|pars ossea (tuba auditiva)|bony part of eustachian tube|pars ossea (tuba auditoria)|osseous portion|pars ossea tubae auditivae|osseous portion of eustachian tube	http://purl.obolibrary.org/obo/UBERON_0007355		
UBERON:0007354	biolink:AnatomicalEntity	cartilage of pharyngotympanic tube	A triangular plate of elastic fibrocartilage that forms the cartilage component of the pharyngotympanic tube.	FMA:60096	hp.json	cartilage of eustachian tube|cartilago tubae auditivae|pharyngotympanic tube cartilage|cartilago tubae auditoriae|cartilago tubae auditivae; cartilago tubae auditoriae|cartilage of auditory tube	http://purl.obolibrary.org/obo/UBERON_0007354		
UBERON:0010996	biolink:AnatomicalEntity	articular cartilage of joint	A thin layer of cartilage, usually hyaline, on the articular surface of bones in synovial joints.	NCIT:C32144|UMLS:C0007303|galen:ArticularCartilage|AEO:0000179|EMAPA:35149|BTO:0001572|FMA:12264|CALOHA:TS-0055|EFO:0001902|GAID:101|MA:0000487|MESH:D002358	hp.json	hyaline cartilage|cartilago articularis|articular cartilage|joint-associated cartilage	http://purl.obolibrary.org/obo/UBERON_0010996		pheno_slim|human_reference_atlas|efo_slim|uberon_slim|vertebrate_core
CHEBI:17325	biolink:ChemicalSubstance	3-hydroxy-3-methylglutarate(2-)	A dicarboxylic acid dianion that results from the removal of a proton from both of the carboxylic acid groups of 3-hydroxy-3-methylglutaric acid.	MetaCyc:CPD-547|KEGG:C03761	hp.json	3-hydroxy-3-methylpentanedioate|3-hydroxy-3-methylglutarate	http://purl.obolibrary.org/obo/CHEBI_17325		3_STAR
NCBITaxon:207598	biolink:OrganismalEntity	Homininae			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_207598		
UBERON:0010986	biolink:AnatomicalEntity	serratus ventralis pre-muscle mass		EHDAA:5992|EHDAA2:0001833	hp.json	serratus anterior pre-muscle mass	http://purl.obolibrary.org/obo/UBERON_0010986		
PR:000002065	biolink:Protein	mast/stem cell growth factor receptor	A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human KIT gene or a 1:1 ortholog thereof.	IUPHARobj:1805|PIRSF:PIRSF500951	hp.json	KIT|CD117|tyrosine-protein kinase Kit|SCFR|proto-oncogene c-Kit|Sl	http://purl.obolibrary.org/obo/PR_000002065		
UBERON:0010984	biolink:AnatomicalEntity	pectoral pre-muscle mass		EHDAA2:0001423	hp.json		http://purl.obolibrary.org/obo/UBERON_0010984		
CHEBI:78295	biolink:ChemicalSubstance	food component	Any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants.		hp.json	dietary components|dietary component|food components	http://purl.obolibrary.org/obo/CHEBI_78295		3_STAR
CHEBI:78298	biolink:ChemicalSubstance	environmental contaminant	Any minor or unwanted substance introduced into the environment that can have undesired effects.		hp.json	environmental contaminants	http://purl.obolibrary.org/obo/CHEBI_78298		3_STAR
UBERON:0034944	biolink:AnatomicalEntity	zone of organ		FMA:55268	hp.json	organ zonal region|organ zone|organ sector|organ region with floating fiat boundary	http://purl.obolibrary.org/obo/UBERON_0034944		
UBERON:0034945	biolink:AnatomicalEntity	excreted gas	Any gaseous product of an excretory process.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034945		
UBERON:0034946	biolink:AnatomicalEntity	gas excreted from digestive tract	Any excreted gas that is produced by the digestive tract.	FMA:78440	hp.json	flatus|intestinal gas|flatulence|flatus	http://purl.obolibrary.org/obo/UBERON_0034946		
UBERON:0034947	biolink:AnatomicalEntity	gas in respiratory system	Any portion of gas located in a part of the respiratory system.		hp.json	respiratory system gas|respiratory gas	http://purl.obolibrary.org/obo/UBERON_0034947		
UBERON:0034948	biolink:AnatomicalEntity	carbon dioxide in respiratory system	Any portion of gas located in a part of the respiratory system that is composed primarily of carbon dioxide.		hp.json	respiratory CO2|respiratory system CO2	http://purl.obolibrary.org/obo/UBERON_0034948		
UBERON:0034953	biolink:AnatomicalEntity	embryonic lymph sac	A population of lymphatic endothelial cell precursors that will form the lymph vessels.	NCIT:C34262	hp.json	primary lymph sac	http://purl.obolibrary.org/obo/UBERON_0034953		
UBERON:0007391	biolink:AnatomicalEntity	pelvic appendage cartilage tissue	A cartilage tissue that is part of a pelvic appendage.	ZFA:0001459|TAO:0001459	hp.json	pelvic fin cartilage	http://purl.obolibrary.org/obo/UBERON_0007391		
UBERON:0007390	biolink:AnatomicalEntity	pectoral appendage cartilage tissue	A cartilage tissue that is part of a pectoral appendage.	ZFA:0000257|TAO:0000257	hp.json	pectoral fin cartilage	http://purl.obolibrary.org/obo/UBERON_0007390		
UBERON:0034969	biolink:AnatomicalEntity	epithelial layer of duct		NCIT:C25787|UMLS:C1512086	hp.json	ductal epithelium|duct epithelium	http://purl.obolibrary.org/obo/UBERON_0034969		
CHEBI:305790	biolink:ChemicalSubstance	thyroxine zwitterion	The amino acid zwitterion formed from thyroxine by transfer of a proton from the carboxy group to the amino group.  Major species at pH 7.3.		hp.json	2-Amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]-propionate|thyroxine|(2S)-2-azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate	http://purl.obolibrary.org/obo/CHEBI_305790		3_STAR
UBERON:0007389	biolink:AnatomicalEntity	paired limb/fin cartilage	A cartilage tissue that is part of a paired limb or fin.	ZFA:0001543|TAO:0001543	hp.json		http://purl.obolibrary.org/obo/UBERON_0007389		homology_grouping
UBERON:0007386	biolink:AnatomicalEntity	pelvic appendage lymph vessel	A lymphatic vessel that is part of a pelvic appendage.		hp.json		http://purl.obolibrary.org/obo/UBERON_0007386		
UBERON:0007385	biolink:AnatomicalEntity	pectoral appendage lymph vessel	A lymphatic vessel that is part of a pectoral appendage.	TAO:0005302|ZFA:0005302	hp.json		http://purl.obolibrary.org/obo/UBERON_0007385		
UBERON:0007384	biolink:AnatomicalEntity	appendage lymph vessel	A lymphatic vessel that is part of a limb/fin.	TAO:0005300|ZFA:0005300	hp.json		http://purl.obolibrary.org/obo/UBERON_0007384		
UBERON:4100117	biolink:AnatomicalEntity	presacral rib	Rib located anterior to the sacral region.		hp.json		http://purl.obolibrary.org/obo/UBERON_4100117		
UBERON:0007383	biolink:AnatomicalEntity	enveloping layer of ectoderm	Outermost layer of cells surrounding the embryo.	TAO:0000086|ZFA:0000086|EFO:0003425	hp.json	EVL|enveloping layer	http://purl.obolibrary.org/obo/UBERON_0007383		efo_slim
GO:0003315	biolink:BiologicalProcess	heart rudiment formation	The developmental process pertaining to the initial formation of the heart rudiment.		hp.json	heart cone formation	http://purl.obolibrary.org/obo/GO_0003315		
HP:0012066	biolink:PhenotypicFeature	Increased urinary disaccharide excretion	Increased concentration of disaccharide in the urine.	UMLS:C4023062	hp.json		http://purl.obolibrary.org/obo/HP_0012066		
GO:0005978	biolink:NamedThing	glycogen biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0005978		
CHEBI:17272	biolink:ChemicalSubstance	propionate	The conjugate base of propionic acid; a key precursor in lipid biosynthesis.	Beilstein:3587503|CAS:72-03-7|PMID:2647392|Gmelin:1820|KEGG:C00163|PMID:18375549|CAS:72-03-7|UM-BBD_compID:c0277|PMID:17951291	hp.json	EtCO2 anion|propanoic acid, ion(1-)|ethanecarboxylate|metacetonate|propanoate|propionate|pseudoacetate|propanoate|ethylformate|propanate|methylacetate|carboxylatoethane|CH3-CH2-COO(-)	http://purl.obolibrary.org/obo/CHEBI_17272		3_STAR
GO:0005979	biolink:NamedThing	regulation of glycogen biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0005979		
HP:0012067	biolink:PhenotypicFeature	Glycopeptiduria	Increased excretion of glycopeptides in the urine. Glycopeptides are peptides with carbohydrate moieties covalently attached to the side chains of the amino acid residues.	UMLS:C4023061	hp.json	High urine glycopeptide levels	http://purl.obolibrary.org/obo/HP_0012067		
GO:0003314	biolink:BiologicalProcess	heart rudiment morphogenesis	The process in which the anatomical structures of the heart rudiment are generated and organized.		hp.json	heart cone morphogenesis	http://purl.obolibrary.org/obo/GO_0003314		
GO:0005976	biolink:BiologicalProcess	polysaccharide metabolic process	The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.		hp.json	glycan metabolic process|glycan metabolism|polysaccharide metabolism|multicellular organismal polysaccharide metabolic process	http://purl.obolibrary.org/obo/GO_0005976		goslim_pir
HP:0012068	biolink:PhenotypicFeature	Aspartylglucosaminuria	Excretion of excess amounts of aspartylglucosamine in the urine.	MSH:D054880|UMLS:C0268225|SNOMEDCT_US:54954004	hp.json	High urine aspartylglucosamine levels	http://purl.obolibrary.org/obo/HP_0012068		
HP:0012069	biolink:PhenotypicFeature	Keratan sulfate excretion in urine	An increased concentration of keratan sulfate in the urine.	UMLS:C4023060	hp.json	Keratan sulphate excretion in urine	http://purl.obolibrary.org/obo/HP_0012069		
GO:0005977	biolink:NamedThing	glycogen metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0005977		
GO:0005975	biolink:BiologicalProcess	carbohydrate metabolic process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.	Wikipedia:Carbohydrate_metabolism	hp.json	carbohydrate metabolism	http://purl.obolibrary.org/obo/GO_0005975		goslim_drosophila|goslim_aspergillus|goslim_chembl|goslim_metagenomics|goslim_yeast|goslim_agr|goslim_candida|goslim_generic|prokaryote_subset|goslim_pombe|goslim_pir|goslim_plant
GO:0003313	biolink:BiologicalProcess	heart rudiment development	The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.		hp.json	heart cone development	http://purl.obolibrary.org/obo/GO_0003313		
HP:0012060	biolink:PhenotypicFeature	Acral lentiginous melanoma	A type of cutaneous melanoma localized to the palm, sole, or beneath the nail (subungual melanoma). Acral lentiginous melanoma starts as a slowly-enlarging flat patch of discoloured skin and usually displays a size above 6 mm and often several centimetres or more in diameter upon diagnosis and variable pigmentation with a mixutre of colors including brown, and blue-grey, black and red. The surface of the lesion is initially smooth but later in the course may become thicker and irregular, and may ulcerate or bleed.	SNOMEDCT_US:16974005|UMLS:C0346037|SNOMEDCT_US:254732008	hp.json		http://purl.obolibrary.org/obo/HP_0012060		
HP:0012061	biolink:PhenotypicFeature	Urinary excretion of sialylated oligosaccharides	Excretion of oligosaccharides conjugated to sialic acid in the urine.	UMLS:C2673302	hp.json	Increased urinary sialyloligosaccharides	http://purl.obolibrary.org/obo/HP_0012061		
HP:0012062	biolink:PhenotypicFeature	Bone cyst	A fluid filled cavity that develops with a bone.	MSH:D001845|UMLS:C0005937|SNOMEDCT_US:203467005|SNOMEDCT_US:203465002|SNOMEDCT_US:66954000|SNOMEDCT_US:112643007	hp.json	Bone cyst|Bone cysts	http://purl.obolibrary.org/obo/HP_0012062		
HP:0012063	biolink:PhenotypicFeature	Aneurysmal bone cyst	Radiographic features include a dilated, radiolucent lesion typically located eccentrically within the metaphyseal portion of the bone, with fluid levels visible on magnetic resonance imaging.	UMLS:C0152244|SNOMEDCT_US:203468000|SNOMEDCT_US:76000001|MSH:D017824	hp.json		http://purl.obolibrary.org/obo/HP_0012063		
HP:0012064	biolink:PhenotypicFeature	Unicameral bone cyst	A benign fluid filled simple cyst of bone filled with serous fluid.	UMLS:C4082185|SNOMEDCT_US:203467005|SNOMEDCT_US:112643007	hp.json		http://purl.obolibrary.org/obo/HP_0012064		
HP:0012065	biolink:PhenotypicFeature	Multiple bony cystic lesions	Presence of multiple cystic changes in multiple areas or multiple bones.	UMLS:C4023063	hp.json	Multiple bony cystic lesions	http://purl.obolibrary.org/obo/HP_0012065		
HP:0000077	biolink:PhenotypicFeature	Abnormality of the kidney	An abnormality of the kidney.	SNOMEDCT_US:90708001|MSH:D007674|SNOMEDCT_US:44513007|UMLS:C0022658|UMLS:C0266292	hp.json	Abnormality of the kidney|Abnormal kidney|Renal anomaly|Renal anomalies	http://purl.obolibrary.org/obo/HP_0000077		
GO:0042923	biolink:MolecularActivity	neuropeptide binding	Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).		hp.json		http://purl.obolibrary.org/obo/GO_0042923		
HP:0000076	biolink:PhenotypicFeature	Vesicoureteral reflux	Abnormal (retrograde) movement of urine from the bladder into ureters or kidneys related to inadequacy of the valvular mechanism at the ureterovesicular junction or other causes.	SNOMEDCT_US:197811007|UMLS:C0042580|MSH:D014718|Fyler:4510	hp.json	Vesico-ureteral reflux|Ureteric reflux|Ureteral reflux|Vesicoureteric reflux	http://purl.obolibrary.org/obo/HP_0000076		
HP:0000079	biolink:PhenotypicFeature	Abnormality of the urinary system	An abnormality of the urinary system.	UMLS:C4021821	hp.json	Urinary tract anomalies|Urinary tract abnormality|Urinary tract abnormalities	http://purl.obolibrary.org/obo/HP_0000079		
HP:0000078	biolink:PhenotypicFeature	Abnormality of the genital system	An abnormality of the genital system.	UMLS:C0281966|UMLS:C0744356	hp.json	Genital abnormalities|Genital defects|Genital anomalies|Abnormality of the reproductive system|Genital abnormality	http://purl.obolibrary.org/obo/HP_0000078		
UBERON:0007418	biolink:AnatomicalEntity	neural decussation	Nerve fibers crossing the midline of the neuraxis relative to their point of origin, on a course to from one level of the nervous system to another. (CUMBO, Heimer, L. The Human Brain, 2nd ed., 1995, pg 6).	NCIT:C28351|FMA:83858|NLX:144064	hp.json	chiasm|neuraxis decussation|decussation|decussation of neuraxis|neuraxis chiasm|neuraxis chiasma|chiasma	http://purl.obolibrary.org/obo/UBERON_0007418		cumbo
UBERON:0007417	biolink:AnatomicalEntity	peduncle of neuraxis		FMA:83860	hp.json	neuraxis peduncle	http://purl.obolibrary.org/obo/UBERON_0007417		
HP:0000071	biolink:PhenotypicFeature	Ureteral stenosis	The presence of a stenotic, i.e., constricted ureter.	SNOMEDCT_US:95574003|UMLS:C0521618	hp.json	Narrowing of the ureter	http://purl.obolibrary.org/obo/HP_0000071		
HP:0000070	biolink:PhenotypicFeature	Ureterocele	A ureterocele is a congenital saccular dilatation of the distal segment of the ureter.	SNOMEDCT_US:12818004|MSH:D014518|UMLS:C0041960	hp.json		http://purl.obolibrary.org/obo/HP_0000070		
UBERON:0007416	biolink:AnatomicalEntity	cerebellar peduncle	Any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem.	NCIT:C88147|MBA:752|FMA:272298|UMLS:C0228515|EMAPA:35213|MA:0002742|BAMS:cbp	hp.json	cerebellum peduncle	http://purl.obolibrary.org/obo/UBERON_0007416		pheno_slim
HP:0000073	biolink:PhenotypicFeature	Ureteral duplication	A developmental anomaly characterized by the presence of two, instead of one, ureter connecting a kidney to the bladder.	SNOMEDCT_US:49496001|UMLS:C0221365	hp.json	Double ureter	http://purl.obolibrary.org/obo/HP_0000073		
HP:0000072	biolink:PhenotypicFeature	Hydroureter	The distention of the ureter with urine.	UMLS:C0521620|SNOMEDCT_US:69758005|UMLS:C4020897|SNOMEDCT_US:95576001	hp.json	Swelling of ureter|Megaureter|Ureteral dilatation|Uroureter|Wide ureter|Dilated ureter	http://purl.obolibrary.org/obo/HP_0000072		
UBERON:0007414	biolink:AnatomicalEntity	nucleus of midbrain tegmentum	A nucleus of brain that spans a midbrain tegmentum.	FMA:258768|ZFA:0005577	hp.json	tegmental nucleus|tegmental nuclei	http://purl.obolibrary.org/obo/UBERON_0007414		
HP:0000075	biolink:PhenotypicFeature	Renal duplication	A congenital anomaly of the urinary tract, in which the kidney is duplicated and is drained via two separate renal pelves and ureters.	UMLS:C0266298|SNOMEDCT_US:30275001	hp.json	Supernumerary kidney|Extra kidney	http://purl.obolibrary.org/obo/HP_0000075		
HP:0000074	biolink:PhenotypicFeature	Ureteropelvic junction obstruction	Blockage of urine flow from the renal pelvis to the proximal ureter.	UMLS:C0521619|SNOMEDCT_US:95575002|MSH:C537373	hp.json	Pelviureteric junction obstruction|Ureteropelvic junction stenosis	http://purl.obolibrary.org/obo/HP_0000074		
HP:0012055	biolink:PhenotypicFeature	Ciliary body melanoma	Malignant tumor of melanocytes of the ciliary body.	SNOMEDCT_US:255015006|NCIT:C3224|UMLS:C0346379	hp.json		http://purl.obolibrary.org/obo/HP_0012055		
HP:0012056	biolink:PhenotypicFeature	Cutaneous melanoma	The presence of a melanoma of the skin.	SNOMEDCT_US:372244006|MSH:D008545|NCIT:C3224|UMLS:C0025202|SNOMEDCT_US:2092003	hp.json		http://purl.obolibrary.org/obo/HP_0012056		
HP:0012057	biolink:PhenotypicFeature	Superficial spreading melanoma	A type of melanoma that is flat and irregular in shape and color, with different shades of black and brown.	UMLS:C0334438|SNOMEDCT_US:254730000|SNOMEDCT_US:55320002	hp.json		http://purl.obolibrary.org/obo/HP_0012057		
HP:0012058	biolink:PhenotypicFeature	Nodular melanoma	A type of melanoma that starts as a raised area that is usually dark blackish-blue or bluish-red but may not have any color.	SNOMEDCT_US:2142002|UMLS:C0334424|SNOMEDCT_US:254731001	hp.json		http://purl.obolibrary.org/obo/HP_0012058		
HP:0012059	biolink:PhenotypicFeature	Lentigo maligna melanoma	A subtype of melanoma in situ that typically develops on sun-damaged skin. The lesion is typically a large, irregularly pigmented macule that has developed from an ordinary lentigo (a small pigmented spot on the skin with a clearly-defined edge). Change to a malignant lentigo typically takes place over 20 years or more, and many patients accept the change as a consequence of aging.	SNOMEDCT_US:44474009|SNOMEDCT_US:302837001|UMLS:C2739810	hp.json		http://purl.obolibrary.org/obo/HP_0012059		
GO:0005981	biolink:NamedThing	regulation of glycogen catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0005981		
HP:0012050	biolink:PhenotypicFeature	Anasarca	An extreme form of generalized edema with widespread and massive edema due to effusion of fluid into the extracellular space.	SNOMEDCT_US:16740003|MSH:D004487|UMLS:C0151603|SNOMEDCT_US:442433009	hp.json	Extreme generalised oedema|Extreme generalized edema	http://purl.obolibrary.org/obo/HP_0012050		
GO:0005980	biolink:NamedThing	glycogen catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0005980		
HP:0012051	biolink:PhenotypicFeature	Reactive hypoglycemia	Hypoglycermia following a meal (or more generally, after intake of glucose).	MSH:D007003|SNOMEDCT_US:237638000|SNOMEDCT_US:317006|UMLS:C0271710	hp.json	Low blood sugar after a meal|Postprandial hypoglycemia	http://purl.obolibrary.org/obo/HP_0012051		
HP:0012052	biolink:PhenotypicFeature	Low serum calcitriol	A reduced concentration of calcitriol in the blood. Calcitriol is also known as 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3.	UMLS:C4023065	hp.json	Low serum 1,25-dihydroxyvitamin D3|Low serum 1,25-dihydroxycholecalciferol	http://purl.obolibrary.org/obo/HP_0012052		
HP:0012053	biolink:PhenotypicFeature	Decreased circulating calcifediol concentration	A reduced concentration of calcifediol in the blood. Calcifediol is also known as calcidiol, 25-hydroxycholecalciferol and 25-Hydroxyvitamin D3.	UMLS:C4023064	hp.json	Decreased 25-hydroxyvitamin D3|Low serum 25-hydroxycholecalciferol|Low serum calcidiol|Low serum calcifediol	http://purl.obolibrary.org/obo/HP_0012053		
HP:0012054	biolink:PhenotypicFeature	Choroidal melanoma	Malignant tumor of melanocytes of the choroid. The classic appearance of choroidal melanoma is a pigmented dome-shaped or collar button-shaped tumor with an associated exudative retinal detachment. Choroidal melanoma is usually pigmented, but can be variably pigmented and even amelanotic (non-pigmented).	NCIT:C3224|UMLS:C0346388|SNOMEDCT_US:255021005	hp.json		http://purl.obolibrary.org/obo/HP_0012054		
PR:000002001	biolink:Protein	receptor-type tyrosine-protein kinase FLT3	A CSF-1/PDGF receptor-type tyrosine-protein kinase that is a translation product of the human FLT3 gene or a 1:1 ortholog thereof.	IUPHARobj:1807|PIRSF:PIRSF500949	hp.json	tyrosine-protein kinase receptor FLT3|tyrosine-protein kinase FLT3|FLT3|FLT-3|FLK2|fetal liver kinase 2|Fms-like tyrosine kinase 3|stem cell tyrosine kinase 1|STK1|FL cytokine receptor|FLK-2|STK-1|CD135|tyrosine-protein kinase receptor flk-2	http://purl.obolibrary.org/obo/PR_000002001		
HP:0000089	biolink:PhenotypicFeature	Renal hypoplasia	Hypoplasia of the kidney.	SNOMEDCT_US:32659003|UMLS:C0266295	hp.json	Hypoplastic kidney|Hypoplastic kidneys|Underdeveloped kidneys|Small kidneys	http://purl.obolibrary.org/obo/HP_0000089		
HP:0000080	biolink:PhenotypicFeature	Abnormality of reproductive system physiology	An abnormal functionality of the genital system.	UMLS:C4021820|UMLS:C4020896	hp.json	Genital functional abnormality|Abnormality of genital physiology|Abnormality of reproductive system physiology	http://purl.obolibrary.org/obo/HP_0000080		
CHEBI:17258	biolink:ChemicalSubstance	7H-purine	The 7H-tautomer of purine.	Beilstein:3200|Reaxys:3200|KEGG:C15587|Gmelin:601779|HMDB:HMDB0001366	hp.json	7H-purine|Purine|Purine base	http://purl.obolibrary.org/obo/CHEBI_17258		3_STAR
HP:0000081	biolink:PhenotypicFeature	Duplicated collecting system	A duplication of the collecting system of the kidney, defined as a kidney with two (instead of, normally, one) pyelocaliceal systems. The pyelocaliceal system is comprised of the renal pelvis and calices. The duplicated renal collecting system can be associated with a single ureter or with double ureters. In the latter case, the two ureters empty separately into the bladder or fuse to form a single ureteral orifice.	UMLS:C1858565	hp.json	Double collecting system|Duplex collecting system|Duplicated renal collecting system|Double urinary collecting systems on intravenous pyelography	http://purl.obolibrary.org/obo/HP_0000081		
HP:0000083	biolink:PhenotypicFeature	Renal insufficiency	A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism.	UMLS:C1565489|MSH:D051437|UMLS:C0035078|SNOMEDCT_US:42399005|UMLS:C1839604|SNOMEDCT_US:236423003	hp.json	Renal failure|Renal failure in adulthood	http://purl.obolibrary.org/obo/HP_0000083		
HP:0000086	biolink:PhenotypicFeature	Ectopic kidney	A developmental defect in which a kidney is located in an abnormal anatomic position.	UMLS:C0238207|SNOMEDCT_US:16507009	hp.json	Abnormal kidney location|Ectopic kidneys|Displaced kidney|Renal ectopia	http://purl.obolibrary.org/obo/HP_0000086		
HP:0000085	biolink:PhenotypicFeature	Horseshoe kidney	A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline.	Fyler:4507|MSH:D000069337|UMLS:C0221353|SNOMEDCT_US:41729002	hp.json	Horseshoe kidney|Horseshoe kidneys|Fused kidneys	http://purl.obolibrary.org/obo/HP_0000085		
HP:0012044	biolink:PhenotypicFeature	Seesaw nystagmus	Seesaw nystagmus is a type of pendular nystagmus where a half cycle consists of the elevation and intorsion of one eye, concurrently with the depression and extortion of the fellow eye. In the other half cycle, there is an inversion of the ocular movements.	MSH:D009759|UMLS:C0344243|SNOMEDCT_US:95782001	hp.json		http://purl.obolibrary.org/obo/HP_0012044		
HP:0012045	biolink:PhenotypicFeature	Retinal flecks	Presence of multiple yellowish-white lesions of various size and configuration on the retina not related to vascular lesions.	SNOMEDCT_US:247138002|UMLS:C0423414	hp.json		http://purl.obolibrary.org/obo/HP_0012045		
HP:0012046	biolink:PhenotypicFeature	Areflexia of upper limbs	Inability to elicit tendon reflexes in the upper limbs.	UMLS:C2674177	hp.json		http://purl.obolibrary.org/obo/HP_0012046		
HP:0012047	biolink:PhenotypicFeature	Hemeralopia	A visual defect characterized by the inability to see as clearly in bright light as in dim light. The word hemeralopia literally means day blindness.	MSH:D014786|SNOMEDCT_US:399323001|UMLS:C0018975	hp.json	Day blindness	http://purl.obolibrary.org/obo/HP_0012047		
HP:0012048	biolink:PhenotypicFeature	Oromandibular dystonia	A kind of focal dystonia characterized by forceful contractions of the face, jaw, and/or tongue causing difficulty in opening and closing the mouth and often affecting chewing and speech.	UMLS:C2242577	hp.json	Cranial dystonia	http://purl.obolibrary.org/obo/HP_0012048		
HP:0012049	biolink:PhenotypicFeature	Laryngeal dystonia	A form of focal dystonia that affects the vocal cords, associated with involuntary contractions of the vocal cords causing interruptions of speech and affecting the voice quality and often leading to patterned, repeated breaks in speech.	UMLS:C1963946|SNOMEDCT_US:3331000119108	hp.json	Spasmodic dysphonia	http://purl.obolibrary.org/obo/HP_0012049		
HP:0012040	biolink:PhenotypicFeature	Corneal stromal edema	Abnormal accumulation of fluid and swelling of the stroma of cornea.	UMLS:C0474444|SNOMEDCT_US:373430008	hp.json	Corneal stromal oedema	http://purl.obolibrary.org/obo/HP_0012040		
HP:0012041	biolink:PhenotypicFeature	Decreased fertility in males		UMLS:C0151640	hp.json	Decreased fertility in males	http://purl.obolibrary.org/obo/HP_0012041		
GO:0030917	biolink:BiologicalProcess	midbrain-hindbrain boundary development	The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.		hp.json	isthmic organizer development|MHB development|isthmomesencephalic boundary development|midbrain-hindbrain orgainizer development|isthmus development	http://purl.obolibrary.org/obo/GO_0030917		
HP:0012042	biolink:PhenotypicFeature	Aspirin-induced asthma	A type of asthma in which aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygen-ase 1 (COX-1) exacerbate bronchoconstriction.	SNOMEDCT_US:407674008|UMLS:C1319853|MSH:D055963	hp.json	Aspirin-induced asthma	http://purl.obolibrary.org/obo/HP_0012042		
HP:0012043	biolink:PhenotypicFeature	Pendular nystagmus	Rhythmic, involuntary sinusoidal oscillations of one or both eyes. The waveform of pendular nystagmus may occur in any direction.	UMLS:C0271388|MSH:D009759|UMLS:C4020734|SNOMEDCT_US:35743001	hp.json	Nystagmus, continuous pendular|Nystagmus, pendular	http://purl.obolibrary.org/obo/HP_0012043		
HP:0000055	biolink:PhenotypicFeature	Abnormality of female external genitalia	An abnormality of the female external genitalia.	UMLS:C4021822	hp.json	Abnormal female external genitalia	http://purl.obolibrary.org/obo/HP_0000055		
HP:0000054	biolink:PhenotypicFeature	Micropenis	Abnormally small penis. At birth, the normal penis is about 3 cm (stretched length from pubic tubercle to tip of penis) with micropenis less than 2.0-2.5 cm.	SNOMEDCT_US:34911001|UMLS:C4551492	hp.json	Small penis|Short penis	http://purl.obolibrary.org/obo/HP_0000054		
HP:0000057	biolink:PhenotypicFeature	obsolete Clitoromegaly			hp.json		http://purl.obolibrary.org/obo/HP_0000057		
HP:0000056	biolink:PhenotypicFeature	Abnormality of the clitoris	An abnormality of the clitoris.	UMLS:C4025893	hp.json	Abnormality of the clit	http://purl.obolibrary.org/obo/HP_0000056		
HP:0000059	biolink:PhenotypicFeature	Hypoplastic labia majora	Undergrowth of the outer labia.	UMLS:C0566899|SNOMEDCT_US:289469003	hp.json	Hypoplasia of labia majora|Small labia majora|Underdeveloped vaginal lips	http://purl.obolibrary.org/obo/HP_0000059		
HP:0000058	biolink:PhenotypicFeature	Abnormal labia morphology	An anomaly of the labia, the externally visible portions of the vulva.	UMLS:C4025892	hp.json	Abnormality of the labia	http://purl.obolibrary.org/obo/HP_0000058		
HP:0000051	biolink:PhenotypicFeature	Perineal hypospadias	Hypospadias with location of the urethral meatus in the perineal region.	UMLS:C0452148|SNOMEDCT_US:204890004	hp.json		http://purl.obolibrary.org/obo/HP_0000051		
HP:0000050	biolink:PhenotypicFeature	Hypoplastic male external genitalia	Underdevelopment of part or all of the male external reproductive organs (which include the penis, the scrotum and the urethra).	UMLS:C1852534	hp.json	Underdeveloped male genitalia|Hypoplastic male genitalia|Small male external genitalia	http://purl.obolibrary.org/obo/HP_0000050		
HP:0000053	biolink:PhenotypicFeature	Macroorchidism	The presence of abnormally large testes.	UMLS:C1263023	hp.json	Large testicles|Large testis	http://purl.obolibrary.org/obo/HP_0000053		
HP:0000052	biolink:PhenotypicFeature	Urethral atresia, male	Congenital anomaly characterized by closure or failure to develop an opening in the urethra in males.	UMLS:C4025894	hp.json		http://purl.obolibrary.org/obo/HP_0000052		
HP:0012033	biolink:PhenotypicFeature	Sacral lipoma	Presence of a lipoma in the region of the sacrum.	UMLS:C4021835	hp.json		http://purl.obolibrary.org/obo/HP_0012033		
GO:0030901	biolink:BiologicalProcess	midbrain development	The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).		hp.json	mesencephalon development	http://purl.obolibrary.org/obo/GO_0030901		
GO:0030902	biolink:BiologicalProcess	hindbrain development	The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).		hp.json	rhombencephalon development	http://purl.obolibrary.org/obo/GO_0030902		
HP:0012034	biolink:PhenotypicFeature	Liposarcoma	Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway.	SNOMEDCT_US:49430005|SNOMEDCT_US:254829001|MSH:D008080|MPATH:418|UMLS:C0023827	hp.json		http://purl.obolibrary.org/obo/HP_0012034		
HP:0012035	biolink:PhenotypicFeature	Steatocystoma multiplex	Multiple, localized or widespread, asymptomatic or inflammatory dermal cysts involving the pilosebaceous units. Lesions can appear anywhere on the body, but steatocystoma multiplex is more commonly involved with those areas of the skin with a high density of developed pilosebaceous units (e.g., the axilla, groin, neck, and proximal extremities).	MSH:D062685|UMLS:C0259771|SNOMEDCT_US:109433009	hp.json		http://purl.obolibrary.org/obo/HP_0012035		
GO:0030900	biolink:BiologicalProcess	forebrain development	The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).		hp.json	prosencephalon development	http://purl.obolibrary.org/obo/GO_0030900		
HP:0012036	biolink:PhenotypicFeature	Sternocleidomastoid amyotrophy	Wasting of the sternocleidomastoid muscle, the muscle in the anterior part of the neck that acts to flex and rotate the head.	UMLS:C4023067	hp.json		http://purl.obolibrary.org/obo/HP_0012036		
GO:0003300	biolink:BiologicalProcess	cardiac muscle hypertrophy	The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0003300		
HP:0012037	biolink:PhenotypicFeature	Pectoralis amyotrophy	Wasting of the pectoral muscles, i.e., of the pectoralis major and pectoralis minor.	UMLS:C4023066	hp.json	Wasting of pec muscles	http://purl.obolibrary.org/obo/HP_0012037		
HP:0012038	biolink:PhenotypicFeature	Corneal guttata	Corneal guttata are droplet-like accumulations of non-banded collagen on the posterior surface of Descemet's membrane. The presence of focal thickenings of Descemet's membrane histologically named guttae. Cornea guttata can be easily diagnosed in vivo and ex vivo by means of specular microscopy as it gives dark areas where no endothelial cells are visible.	UMLS:C0271288|SNOMEDCT_US:373424008	hp.json	Corneal endothelial guttata	http://purl.obolibrary.org/obo/HP_0012038		
HP:0012039	biolink:PhenotypicFeature	Descemet Membrane Folds	Presence of folds in the Descemet membrane, which is the basement membrane of the endothelial (inner) cell layer of the cornea. Descemet membrane folds are generally a manifestation of inflammation or edema of the cornea.	SNOMEDCT_US:193821003|UMLS:C0155116	hp.json		http://purl.obolibrary.org/obo/HP_0012039		
GO:0003301	biolink:BiologicalProcess	physiological cardiac muscle hypertrophy	The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.		hp.json		http://purl.obolibrary.org/obo/GO_0003301		
HP:0012030	biolink:PhenotypicFeature	Increased urinary cortisol level	Abnormally increased concentration of cortisol in the urine.	UMLS:C4023068	hp.json	High urine cortisol level	http://purl.obolibrary.org/obo/HP_0012030		
HP:0012031	biolink:PhenotypicFeature	Lipomatous tumor		MSH:D018205|SNOMEDCT_US:254831005|SNOMEDCT_US:115227001|MPATH:415|UMLS:C0206631|SNOMEDCT_US:254827004	hp.json	Lipomatous tumour	http://purl.obolibrary.org/obo/HP_0012031		
GO:0030903	biolink:BiologicalProcess	notochord development	The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.		hp.json		http://purl.obolibrary.org/obo/GO_0030903		
HP:0012032	biolink:PhenotypicFeature	Lipoma	Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous.	MPATH:417|UMLS:C0023798|SNOMEDCT_US:46720004|MSH:D008067|SNOMEDCT_US:93163002|MEDDRA:10024612	hp.json	Noncancerous fatty lump|Fatty lump	http://purl.obolibrary.org/obo/HP_0012032		hposlim_core
HP:0000066	biolink:PhenotypicFeature	Labial hypoplasia		UMLS:C1850325	hp.json	Hypoplastic labia|Underdeveloped labia	http://purl.obolibrary.org/obo/HP_0000066		
HP:0000065	biolink:PhenotypicFeature	Labial hypertrophy		SNOMEDCT_US:16924008|UMLS:C0404531	hp.json	Enlargement of the labia|Enlargement of the vaginal lips|Enlarged vaginal lips	http://purl.obolibrary.org/obo/HP_0000065		
HP:0000068	biolink:PhenotypicFeature	Urethral atresia	Congenital anomaly characterized by closure or failure to develop an opening in the urethra.	UMLS:C1610065	hp.json	Urethral opening absent|Absent urethral opening	http://purl.obolibrary.org/obo/HP_0000068		
HP:0000067	biolink:PhenotypicFeature	Urethral atresia, female	Congenital anomaly characterized by closure or failure to develop an opening in the urethra in females.	UMLS:C4025890	hp.json		http://purl.obolibrary.org/obo/HP_0000067		
HP:0000069	biolink:PhenotypicFeature	Abnormality of the ureter	An abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder.	UMLS:C1840382	hp.json	Ureter issue|Abnormality of the ureters|Ureteral anomalies	http://purl.obolibrary.org/obo/HP_0000069		
HP:0000060	biolink:PhenotypicFeature	Clitoral hypoplasia	Developmental hypoplasia of the clitoris.	UMLS:C1844527	hp.json	Underdeveloped clit|Hypoplastic clitoris|Small clitoris	http://purl.obolibrary.org/obo/HP_0000060		
HP:0000062	biolink:PhenotypicFeature	Ambiguous genitalia	A genital phenotype that is not clearly assignable to a single gender. Ambiguous genitalia can be evaluated using the Prader scale: Prader 0: Normal female external genitalia. Prader 1: Female external genitalia with clitoromegaly. Prader 2: Clitoromegaly with partial labial fusion forming a funnel-shaped urogenital sinus. Prader 3: Increased phallic enlargement. Complete labioscrotal fusion forming a urogenital sinus with a single opening. Prader 4: Complete scrotal fusion with urogenital opening at the base or on the shaft of the phallus. Prader 5: Normal male external genitalia. The diagnosis of ambiguous genitalia is made for Prader 1-4.	SNOMEDCT_US:21321009|UMLS:C0266362|MSH:D012734	hp.json	Intersex genitalia|Ambiguous external genitalia at birth|Ambiguous external genitalia	http://purl.obolibrary.org/obo/HP_0000062		
HP:0000061	biolink:PhenotypicFeature	Ambiguous genitalia, female	Ambiguous genitalia in an individual with XX genetic gender.	UMLS:C1859980|UMLS:C4025891	hp.json	Atypical appearance of female genitals|Ambiguous genitalia due to virilization	http://purl.obolibrary.org/obo/HP_0000061		
HP:0000064	biolink:PhenotypicFeature	Hypoplastic labia minora		UMLS:C1849295	hp.json	Underdeveloped inner lips	http://purl.obolibrary.org/obo/HP_0000064		
HP:0000063	biolink:PhenotypicFeature	Fused labia minora	Fusion of the labia minora as a result of labial adhesions resulting in vaginal obstruction.	UMLS:C1837532	hp.json	Fused inner lips	http://purl.obolibrary.org/obo/HP_0000063		
GO:0005930	biolink:CellularComponent	axoneme	The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.	Wikipedia:Axoneme	hp.json	flagellum axoneme|cilium axoneme|flagellar axoneme|ciliary axoneme	http://purl.obolibrary.org/obo/GO_0005930		goslim_pir
CHEBI:32867	biolink:ChemicalSubstance	D-prolinate	An optically active form of prolinate having D-configuration.	Gmelin:533350	hp.json	D-prolinate|D-proline anion|(2R)-pyrrolidine-2-carboxylate	http://purl.obolibrary.org/obo/CHEBI_32867		3_STAR
CHEBI:29214	biolink:ChemicalSubstance	sulfonic acid		Gmelin:1404640	hp.json	[SHO2(OH)]|HSHO3|sulphonic acid|Sulfonsaeure|acide sulfonique|hydridohydroxidodioxidosulfur|sulfonic acid	http://purl.obolibrary.org/obo/CHEBI_29214		3_STAR
CHEBI:32868	biolink:ChemicalSubstance	D-prolinium	An optically active form of prolinium having D-configuration.	Gmelin:363492	hp.json	(2R)-2-carboxypyrrolidinium|D-proline cation|D-prolinium	http://purl.obolibrary.org/obo/CHEBI_32868		3_STAR
CHEBI:32860	biolink:ChemicalSubstance	valinium		Gmelin:1651060	hp.json	valinium|1-carboxy-2-methylpropan-1-aminium|valine cation|H2val(+)	http://purl.obolibrary.org/obo/CHEBI_32860		3_STAR
CHEBI:32862	biolink:ChemicalSubstance	L-prolinate	An optically active form of prolinate having L-configuration.	Gmelin:82610|Beilstein:4307988|Reaxys:4307988	hp.json	L-prolinate|L-proline anion|(2S)-pyrrolidine-2-carboxylate	http://purl.obolibrary.org/obo/CHEBI_32862		3_STAR
CHEBI:32864	biolink:ChemicalSubstance	L-prolinium	An optically active form of prolinium having L-configuration.	Gmelin:363493	hp.json	L-prolinium|L-proline cation|(2S)-2-carboxypyrrolidinium	http://purl.obolibrary.org/obo/CHEBI_32864		3_STAR
GO:0005938	biolink:CellularComponent	cell cortex	The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.	Wikipedia:Cell_cortex	hp.json	cell periphery|peripheral cytoplasm	http://purl.obolibrary.org/obo/GO_0005938		goslim_yeast|goslim_candida|goslim_aspergillus
HP:0012099	biolink:PhenotypicFeature	Abnormality of circulating catecholamine level	An abnormal catecholamine concentration in the blood.	UMLS:C4021102	hp.json	Catecholamine levels abnormal	http://purl.obolibrary.org/obo/HP_0012099		
CHEBI:32876	biolink:ChemicalSubstance	tertiary amine	A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups.	KEGG:C02196	hp.json	tertiary amines|R3N|tertiaeres Amin|Tertiary amine	http://purl.obolibrary.org/obo/CHEBI_32876		3_STAR
HP:0012091	biolink:PhenotypicFeature	Abnormality of pancreas physiology	An anomaly of the function of the pancreas.	UMLS:C4023048	hp.json		http://purl.obolibrary.org/obo/HP_0012091		
CHEBI:32877	biolink:ChemicalSubstance	primary amine	A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group.	KEGG:C00893|KEGG:C00375|KEGG:C02580	hp.json	primary amines|R-NH2|primaeres Amin|Primary monoamine|RCH2NH2|Primary amine	http://purl.obolibrary.org/obo/CHEBI_32877		3_STAR
HP:0012092	biolink:PhenotypicFeature	Abnormality of exocrine pancreas physiology	A functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes.	UMLS:C4021103	hp.json	Abnormal exocrine pancreatic function	http://purl.obolibrary.org/obo/HP_0012092		
HP:0012093	biolink:PhenotypicFeature	Abnormality of endocrine pancreas physiology	A function abnormality of the endocrine pancreas.	UMLS:C4023047	hp.json		http://purl.obolibrary.org/obo/HP_0012093		
CHEBI:32879	biolink:ChemicalSubstance	propane		Gmelin:25044|CAS:74-98-6|Beilstein:1730718|CAS:74-98-6	hp.json	CH3-CH2-CH3|Propan|propane|propane|E944	http://purl.obolibrary.org/obo/CHEBI_32879		3_STAR
HP:0012094	biolink:PhenotypicFeature	Abnormal pancreas size	A deviation from the normal size of the pancreas.	UMLS:C4023046	hp.json	Abnormal pancreas size	http://purl.obolibrary.org/obo/HP_0012094		
HP:0012095	biolink:PhenotypicFeature	Multiple joint dislocation	Dislocation of many joints.	SNOMEDCT_US:34277002|UMLS:C0332792|SNOMEDCT_US:287096003	hp.json	Multiple joint dislocations	http://purl.obolibrary.org/obo/HP_0012095		
HP:0012096	biolink:PhenotypicFeature	Intracranial epidermoid cyst	A congenital inclusion cysts that arises from ectodermal cells that normally form skin cells being left behind in the nervous system during development.	UMLS:C4023045	hp.json		http://purl.obolibrary.org/obo/HP_0012096		
HP:0012097	biolink:PhenotypicFeature	Intracranial dermoid cyst	A congenital inclusion cysts that arises from the inclusion of ectodermally committed cells at the time of neural tube closure (3rd-5th week of embryogenesis). The capsule of dermoid cysts consists of simple epithelium supported by collagen. In thicker parts, the lining is supplemented with dermis containing hair follicles, sebaceous glands, and apocrine glands.	UMLS:C4023044	hp.json		http://purl.obolibrary.org/obo/HP_0012097		
HP:0012098	biolink:PhenotypicFeature	Edema of the dorsum of feet	An abnormal accumulation of fluid beneath the skin on the back of the feet.	UMLS:C2919341|SNOMEDCT_US:445124008	hp.json	Oedema of dorsum of feet|Edema of dorsum of feet|Oedema of the dorsum of feet	http://purl.obolibrary.org/obo/HP_0012098		
CHEBI:32871	biolink:ChemicalSubstance	prolinate	An alpha-amino-acid anion that is the conjugate base of proline, arising from deprotonation of the carboxy group.	Beilstein:5387795|Reaxys:5387795|Gmelin:50151	hp.json	pro(-)|prolinate|pyrrolidine-2-carboxylate|proline anion	http://purl.obolibrary.org/obo/CHEBI_32871		3_STAR
CHEBI:32872	biolink:ChemicalSubstance	prolinium	An alpha-amino-acid cation that is the conjugate acid of proline, arising from protonation of the amino group.		hp.json	2-carboxypyrrolidinium|H2pro(+)|proline cation|prolinium	http://purl.obolibrary.org/obo/CHEBI_32872		3_STAR
CHEBI:30212	biolink:ChemicalSubstance	photon	Particle of zero charge, zero rest mass, spin quantum number 1, energy hnu and momentum hnu/c (h is the Planck constant, nu the frequency of radiation and c the speed of light), carrier of electromagnetic force.	KEGG:C00205	hp.json	Light|photon|foton|gamma|Lichtquant|light quantum|hnu|hnu	http://purl.obolibrary.org/obo/CHEBI_30212		3_STAR
HP:0012088	biolink:PhenotypicFeature	Abnormal urinary odor	A deviation from the normal odor of the urine.	SNOMEDCT_US:8769003|UMLS:C0278045	hp.json	Abnormal urinary odour|Abnormal urinary odor|Abnormal urine smell	http://purl.obolibrary.org/obo/HP_0012088		
HP:0012089	biolink:PhenotypicFeature	Arteritis	Arterial inflammation.	UMLS:C0003860|SNOMEDCT_US:52089001|MSH:D001167	hp.json	Inflammation of artery	http://purl.obolibrary.org/obo/HP_0012089		
GO:0005911	biolink:CellularComponent	cell-cell junction	A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.	NIF_Subcellular:sao1922892319	hp.json	cell-cell contact region|intercellular junction|cell-cell contact zone	http://purl.obolibrary.org/obo/GO_0005911		
HP:0012080	biolink:PhenotypicFeature	Cerebellar granular layer atrophy	Atrophy of the cerebellum affecting primarily the granular cell layer.	UMLS:C4023054	hp.json		http://purl.obolibrary.org/obo/HP_0012080		
GO:0042981	biolink:BiologicalProcess	regulation of apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process.		hp.json	apoptosis regulator activity|regulation of apoptosis	http://purl.obolibrary.org/obo/GO_0042981		
HP:0012081	biolink:PhenotypicFeature	Enlarged cerebellum	An abnormally increased size of the cerebellum compared to other brain structures.	UMLS:C3278024	hp.json		http://purl.obolibrary.org/obo/HP_0012081		
CHEBI:32845	biolink:ChemicalSubstance	serinate	An alpha-amino-acid anion that is the conjugate base of serine.	Gmelin:324692	hp.json	2-amino-3-hydroxypropanoate|serinate|serine anion	http://purl.obolibrary.org/obo/CHEBI_32845		3_STAR
HP:0012082	biolink:PhenotypicFeature	Cerebellar Purkinje layer atrophy	Atrophy of the cerebellum affecting primarily the Purkinje cell layer.	UMLS:C4023053	hp.json		http://purl.obolibrary.org/obo/HP_0012082		
CHEBI:32846	biolink:ChemicalSubstance	serinium	An alpha-amino-acid cation that is the conjugate acid of serine.	Gmelin:1925675	hp.json	serine cation|serinium|1-carboxy-2-hydroxyethanaminium	http://purl.obolibrary.org/obo/CHEBI_32846		3_STAR
HP:0012083	biolink:PhenotypicFeature	Ubiquitin-positive cerebral inclusion bodies	Nuclear or cytoplasmic aggregates that show positive staining with antibodies against ubiquitin within cells of the brain.	UMLS:C4023052	hp.json		http://purl.obolibrary.org/obo/HP_0012083		
HP:0012084	biolink:PhenotypicFeature	Abnormality of skeletal muscle fiber size	Any abnormality of the size of the skeletal muscle cell.	UMLS:C4023051	hp.json	Abnormality of skeletal muscle fibre size	http://purl.obolibrary.org/obo/HP_0012084		
HP:0012085	biolink:PhenotypicFeature	Pyuria	The presence of 10 or more white cells per cubic millimeter in a urine specimen, 3 or more white cells per high-power field of unspun urine, a positive result on Gram staining of an unspun urine specimen, or a urinary dipstick test that is positive for leukocyte esterase.	SNOMEDCT_US:275765006|SNOMEDCT_US:4800001|MSH:D011776|UMLS:C0034359	hp.json	High urine neutrophil count|Leukocyturia	http://purl.obolibrary.org/obo/HP_0012085		
HP:0012086	biolink:PhenotypicFeature	Abnormal urinary color	An abnormal color of the urine, that is, the color of the urine appears different from the usual straw-yellow color.	UMLS:C0522153|SNOMEDCT_US:102867009|SNOMEDCT_US:167239007	hp.json	Abnormal urine color|Abnormal urinary color|Abnormal urinary colour|Abnormal urine colour	http://purl.obolibrary.org/obo/HP_0012086		
HP:0012087	biolink:PhenotypicFeature	Abnormal mitochondrial shape	An anomaly in the surface contour of mitochondria.	UMLS:C4023050	hp.json		http://purl.obolibrary.org/obo/HP_0012087		
HP:0000099	biolink:PhenotypicFeature	Glomerulonephritis	Inflammation of the renal glomeruli.	UMLS:C0017658|SNOMEDCT_US:36171008|MSH:D005921	hp.json	Glomerular nephritis	http://purl.obolibrary.org/obo/HP_0000099		
HP:0000098	biolink:PhenotypicFeature	Tall stature	A height above that which is expected according to age and gender norms.	SNOMEDCT_US:248328003|UMLS:C0241240	hp.json	Accelerated linear growth|Tall stature|Increased linear growth|Increased body height	http://purl.obolibrary.org/obo/HP_0000098		
HP:0012090	biolink:PhenotypicFeature	Abnormal pancreas morphology		UMLS:C4023049	hp.json	Abnormally shaped pancreas|Abnormality of pancreas morphology	http://purl.obolibrary.org/obo/HP_0012090		
HP:0000091	biolink:PhenotypicFeature	Abnormal renal tubule morphology	An abnormality of the renal tubules.	UMLS:C4021826	hp.json	Morphologic abnormality of the renal tubules|Abnormality of the renal tubule	http://purl.obolibrary.org/obo/HP_0000091		
HP:0000090	biolink:PhenotypicFeature	Nephronophthisis	Presence of cysts at the corticomedullary junction of the kidney in combination with tubulointerstitial fibrosis.	UMLS:C0687120|SNOMEDCT_US:204958008	hp.json	juvenile nephronophthisis	http://purl.obolibrary.org/obo/HP_0000090		
HP:0000093	biolink:PhenotypicFeature	Proteinuria	Increased levels of protein in the urine.	SNOMEDCT_US:29738008|MSH:D011507|UMLS:C0033687	hp.json	High urine protein levels|Protein in urine	http://purl.obolibrary.org/obo/HP_0000093		
HP:0000092	biolink:PhenotypicFeature	Renal tubular atrophy	The presence of renal tubules with thick redundant basement membranes, or a reduction of greater than 50% in tubular diameter compared to surrounding non-atrophic tubules.	UMLS:C1858395	hp.json	Tubular atrophy|Renal tubular cell atrophy	http://purl.obolibrary.org/obo/HP_0000092		
HP:0000095	biolink:PhenotypicFeature	Abnormal renal glomerulus morphology	A structural anomaly of the glomerulus.	UMLS:C4025889	hp.json	Morphologic abnormality of the renal glomerulus|Abnormality of renal glomerulus morphology	http://purl.obolibrary.org/obo/HP_0000095		
HP:0000097	biolink:PhenotypicFeature	Focal segmental glomerulosclerosis	Segmental accumulation of scar tissue in individual (but not all) glomeruli.	SNOMEDCT_US:25821008|UMLS:C0017668|MSH:D005923|SNOMEDCT_US:236403004	hp.json	focal glomerulosclerosis|Focal and segmental glomerular sclerosis|Focal and segmental glomerulosclerosis	http://purl.obolibrary.org/obo/HP_0000097		
HP:0000096	biolink:PhenotypicFeature	Glomerular sclerosis	Accumulation of scar tissue within the glomerulus.	UMLS:C0178664|SNOMEDCT_US:197661001|SNOMEDCT_US:82646005	hp.json	Renal glomerular fibrosis|Glomerulosclerosis	http://purl.obolibrary.org/obo/HP_0000096		
HP:0012077	biolink:PhenotypicFeature	Histrionic personality disorder	A personality disorder characterized by shallow and labile affectivity, self-dramatization, theatricality, exaggerated expression of emotions, suggestibility, egocentricity, self-indulgence, lack of consideration for others, easily hurt feelings, and continuous seeking for appreciation, excitement and attention.	MSH:D006677|ICD-10:F60.4|UMLS:C0019681|SNOMEDCT_US:55341008	hp.json		http://purl.obolibrary.org/obo/HP_0012077		
HP:0012078	biolink:PhenotypicFeature	Motor conduction block	Blockade of impulses at a focal site along the course of a motor axon.	UMLS:C4023056	hp.json		http://purl.obolibrary.org/obo/HP_0012078		
HP:0012079	biolink:PhenotypicFeature	Abnormality of central motor conduction	Any anomaly of the conduction of motor nerve impulses in the central nervous system.	UMLS:C4023055	hp.json		http://purl.obolibrary.org/obo/HP_0012079		
HP:0012070	biolink:PhenotypicFeature	Chondroitin sulfate excretion in urine	An increased concentration of chondroitin sulfate (CHEBI:37397) in the urine.	UMLS:C4023059	hp.json	Chondroitin sulphate excretion in urine	http://purl.obolibrary.org/obo/HP_0012070		
HP:0012071	biolink:PhenotypicFeature	Abnormal circulating acetylcarnitine concentration	Any deviation from the normal concentration in the blood circulation of acylcarnitine, which is produced by reversible esterification of the 3-hydroxyl group of carnitine.	UMLS:C4020733|UMLS:C4023058	hp.json	Abnormal circulating esterified carnitine concentration|Abnormal acetylcarnitine profile	http://purl.obolibrary.org/obo/HP_0012071		
HP:0012072	biolink:PhenotypicFeature	Aciduria	Excretion of urine with an acid pH, i.e., having an increased hydrogen ion concentration.	UMLS:C0278026|SNOMEDCT_US:21806007	hp.json	Acidic urine	http://purl.obolibrary.org/obo/HP_0012072		
HP:0012073	biolink:PhenotypicFeature	Abnormal urinary acylglycine profile	An abnormal distribution of N-acylglycines in the urine. There are numerous different N-acylglycines, and this term refers to pathological alterations in their level or distribution.	UMLS:C4023057	hp.json		http://purl.obolibrary.org/obo/HP_0012073		
CHEBI:32859	biolink:ChemicalSubstance	valinate		Gmelin:49876	hp.json	val(-)|2-amino-3-methylbutanoate|valinate|valine anion	http://purl.obolibrary.org/obo/CHEBI_32859		3_STAR
HP:0012074	biolink:PhenotypicFeature	Tonic pupil	An abnormality of the pupillary light reaction characterized by a marked slowing of the light reaction of usually just one pupil. The pupil tends to be relatively dilated, and there is reduced accommodation.	SNOMEDCT_US:24225004|UMLS:C0040416|MSH:D015845	hp.json	Adie's tonic pupil|Adie pupil	http://purl.obolibrary.org/obo/HP_0012074		hposlim_core
HP:0012075	biolink:PhenotypicFeature	Personality disorder	An abnormality of mental functioning affecting the personality and behavioural tendencies of an individual and characterized by a rigid and unhealthy pattern of thinking and behavior. The definition of a personal disorder implies that the abnormality is not the result of damage or insult to the brain or from another psychiatric disorder.	ICD-10:F60|MSH:D010554|SNOMEDCT_US:33449004|UMLS:C0031212	hp.json		http://purl.obolibrary.org/obo/HP_0012075		
HP:0012076	biolink:PhenotypicFeature	Borderline personality disorder	A personality disorder characterized by impulsive behavior and unpredictable and capricious mood. Affected individuals show a liability to outbursts of emotion and an incapacity to control the behavioural explosions.	SNOMEDCT_US:20010003|ICD-10:F60.3|UMLS:C0006012|MSH:D001883	hp.json	BPD	http://purl.obolibrary.org/obo/HP_0012076		
GO:0042996	biolink:BiologicalProcess	regulation of Golgi to plasma membrane protein transport	Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0042996		
GO:0042995	biolink:CellularComponent	cell projection	A prolongation or process extending from a cell, e.g. a flagellum or axon.		hp.json	cellular process|cell process|cellular projection	http://purl.obolibrary.org/obo/GO_0042995		goslim_mouse|goslim_agr|prokaryote_subset|goslim_pir|goslim_flybase_ribbon
GO:0042998	biolink:BiologicalProcess	positive regulation of Golgi to plasma membrane protein transport	Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.		hp.json	upregulation of Golgi to plasma membrane protein transport|up regulation of Golgi to plasma membrane protein transport|stimulation of Golgi to plasma membrane protein transport|up-regulation of Golgi to plasma membrane protein transport|activation of Golgi to plasma membrane protein transport	http://purl.obolibrary.org/obo/GO_0042998		
GO:0042997	biolink:BiologicalProcess	negative regulation of Golgi to plasma membrane protein transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.		hp.json	down regulation of Golgi to plasma membrane protein transport|inhibition of Golgi to plasma membrane protein transport|down-regulation of Golgi to plasma membrane protein transport|downregulation of Golgi to plasma membrane protein transport	http://purl.obolibrary.org/obo/GO_0042997		
GO:0005929	biolink:CellularComponent	cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.	Wikipedia:Cilium|FMA:67181|NIF_Subcellular:sao787716553	hp.json	primary cilium|eukaryotic flagellum|flagellum|microtubule-based flagellum	http://purl.obolibrary.org/obo/GO_0005929		goslim_generic|goslim_pir|goslim_drosophila|goslim_chembl
CHEBI:17234	biolink:ChemicalSubstance	glucose	An aldohexose used as a source of energy and metabolic intermediate.	KEGG:C00293|CAS:50-99-7|Wikipedia:Glucose	hp.json	Glc|glucose|Glucose|DL-glucose|gluco-hexose|Glukose	http://purl.obolibrary.org/obo/CHEBI_17234		3_STAR
UBERON:0007425	biolink:AnatomicalEntity	decussation of diencephalon	A neural decussation that is part of a diencephalon.	FMA:62446	hp.json	diencephalon decussation	http://purl.obolibrary.org/obo/UBERON_0007425		
HP:0002659	biolink:PhenotypicFeature	Increased susceptibility to fractures	An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture.	UMLS:C1390474	hp.json	Increased tendency to fractures|Frequent broken bones|Increased susceptibility to fractures|Bone fragility|Increased bone fragility|Abnormal susceptibility to fractures	http://purl.obolibrary.org/obo/HP_0002659		
HP:0002652	biolink:PhenotypicFeature	Skeletal dysplasia	A general term describing features characterized by abnormal development of bones and connective tissues.	SNOMEDCT_US:240190009|UMLS:C4280567|MSH:D010009|UMLS:C0029422|SNOMEDCT_US:105985007	hp.json	Abnormal skeletal development	http://purl.obolibrary.org/obo/HP_0002652		
HP:0002653	biolink:PhenotypicFeature	Bone pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.	SNOMEDCT_US:12584003|UMLS:C0151825	hp.json	Bone pain	http://purl.obolibrary.org/obo/HP_0002653		
HP:0002650	biolink:PhenotypicFeature	Scoliosis	The presence of an abnormal lateral curvature of the spine.	SNOMEDCT_US:64217002|UMLS:C0037932|UMLS:C0700208|Fyler:4160|SNOMEDCT_US:111266001|MSH:D013121	hp.json		http://purl.obolibrary.org/obo/HP_0002650		hposlim_core
HP:0002651	biolink:PhenotypicFeature	Spondyloepimetaphyseal dysplasia		UMLS:C0432211|SNOMEDCT_US:254062008	hp.json		http://purl.obolibrary.org/obo/HP_0002651		
HP:0002656	biolink:PhenotypicFeature	Epiphyseal dysplasia		UMLS:C4280566|SNOMEDCT_US:254080004|UMLS:C0392476	hp.json	Abnormal development of the ends of long bones in arms and legs|Abnormal development of end part of bone	http://purl.obolibrary.org/obo/HP_0002656		
HP:0002657	biolink:PhenotypicFeature	Spondylometaphyseal dysplasia		UMLS:C0700635|SNOMEDCT_US:702350003|MSH:C537501	hp.json		http://purl.obolibrary.org/obo/HP_0002657		
HP:0002654	biolink:PhenotypicFeature	Multiple epiphyseal dysplasia		SNOMEDCT_US:59708000|MSH:D010009|UMLS:C0026760	hp.json		http://purl.obolibrary.org/obo/HP_0002654		
HP:0002655	biolink:PhenotypicFeature	Spondyloepiphyseal dysplasia	A disorder of bone growth affecting the vertebrae and the ends of the long bones (epiphyses).	UMLS:C0038015|MSH:D010009	hp.json	Spondyloepiphyseal dysplasia tarda	http://purl.obolibrary.org/obo/HP_0002655		
HP:0000008	biolink:PhenotypicFeature	Abnormal morphology of female internal genitalia	An abnormality of the female internal genitalia.	UMLS:C4025900	hp.json	Abnormality of female internal genitalia	http://purl.obolibrary.org/obo/HP_0000008		
HP:0000007	biolink:PhenotypicFeature	Autosomal recessive inheritance	A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).	UMLS:C4020899|SNOMEDCT_US:258211005|UMLS:C0441748	hp.json	biallelic_autosomal|Autosomal recessive predisposition|Autosomal recessive|Autosomal recessive form	http://purl.obolibrary.org/obo/HP_0000007		
HP:0002669	biolink:PhenotypicFeature	Osteosarcoma	A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor.	SNOMEDCT_US:21708004|MSH:D012516|UMLS:C0029463|NCIT:C9145|SNOMEDCT_US:307576001	hp.json	Bone cell cancer|Osteogenic sarcoma	http://purl.obolibrary.org/obo/HP_0002669		
HP:0000009	biolink:PhenotypicFeature	Functional abnormality of the bladder	Dysfunction of the urinary bladder.	UMLS:C3806583	hp.json	Poor bladder function	http://purl.obolibrary.org/obo/HP_0000009		
HP:0002663	biolink:PhenotypicFeature	Delayed epiphyseal ossification		UMLS:C4280565|UMLS:C1865200	hp.json	Delayed epiphyseal maturation|Delayed opacification of the epiphyses|Epiphyseal ossification delay|Delayed maturation of end part of long bone	http://purl.obolibrary.org/obo/HP_0002663		
HP:0002664	biolink:PhenotypicFeature	Neoplasm	An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumour).	MSH:D009369|SNOMEDCT_US:363346000|UMLS:C0027651|NCIT:C3262|SNOMEDCT_US:108369006|UMLS:C0006826	hp.json	Abnormal tissue mass|Oncology|Oncological abnormality|Cancer|Tumour|Tumor|Neoplasia	http://purl.obolibrary.org/obo/HP_0002664		
HP:0000002	biolink:PhenotypicFeature	Abnormality of body height	Deviation from the norm of height with respect to that which is expected according to age and gender norms.	UMLS:C4025901	hp.json	Abnormality of body height	http://purl.obolibrary.org/obo/HP_0000002		
HP:0002661	biolink:PhenotypicFeature	Painless fractures due to injury	An increased tendency to fractures following trauma, with fractures occurring without pain.	UMLS:C1837602	hp.json	Painless fractures due to injury	http://purl.obolibrary.org/obo/HP_0002661		
HP:0000001	biolink:PhenotypicFeature	All		UMLS:C0444868	hp.json		http://purl.obolibrary.org/obo/HP_0000001		
HP:0002667	biolink:PhenotypicFeature	Nephroblastoma	The presence of a nephroblastoma, which is a neoplasm of the kidney that primarily affects children.	NCIT:C40407|SNOMEDCT_US:25081006|MSH:D009396|UMLS:C0027708|SNOMEDCT_US:302849000	hp.json	Wilm's tumour|Wilms tumour|Wilms tumor|Wilm's tumor	http://purl.obolibrary.org/obo/HP_0002667		
HP:0002668	biolink:PhenotypicFeature	Paraganglioma	A carotid body tumor (also called paraganglionoma or chemodectoma) is a tumor found in the upper neck at the branching of the carotid artery. They arise from the chemoreceptor organ (paraganglion) located in the adventitia of the carotid artery bifurcation.	SNOMEDCT_US:302833002|SNOMEDCT_US:803009|SNOMEDCT_US:127027008|MSH:D010235|SNOMEDCT_US:72787006|NCIT:C3308|UMLS:C0030421|SNOMEDCT_US:253029009	hp.json	Carotid body tumors|Carotid body tumours|Paragangliomas	http://purl.obolibrary.org/obo/HP_0002668		
HP:0000003	biolink:PhenotypicFeature	Multicystic kidney dysplasia	Multicystic dysplasia of the kidney is characterized by multiple cysts of varying size in the kidney and the absence of a normal pelvicaliceal system. The condition is associated with ureteral or ureteropelvic atresia, and the affected kidney is nonfunctional.	UMLS:C3714581|MSH:D021782|SNOMEDCT_US:204962002|SNOMEDCT_US:82525005	hp.json	Multicystic renal dysplasia|Multicystic dysplastic kidney|Multicystic kidneys	http://purl.obolibrary.org/obo/HP_0000003		
HP:0002665	biolink:PhenotypicFeature	Lymphoma	A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells.	UMLS:C0024299|SNOMEDCT_US:21964009|MSH:D008223|SNOMEDCT_US:118600007|NCIT:C7065|SNOMEDCT_US:115244002|SNOMEDCT_US:188676008	hp.json	Cancer of lymphatic system	http://purl.obolibrary.org/obo/HP_0002665		
HP:0000006	biolink:PhenotypicFeature	Autosomal dominant inheritance	A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.	UMLS:C0443147|SNOMEDCT_US:263681008	hp.json	Autosomal dominant form|Autosomal dominant|Autosomal dominant type|monoallelic_autosomal	http://purl.obolibrary.org/obo/HP_0000006		
HP:0000005	biolink:PhenotypicFeature	Mode of inheritance	The pattern in which a particular genetic trait or disorder is passed from one generation to the next.	UMLS:C1708511	hp.json	Inheritance	http://purl.obolibrary.org/obo/HP_0000005		
HP:0002666	biolink:PhenotypicFeature	Pheochromocytoma	Pheochromocytomas (also known as chromaffin tumors) produce, store, and secrete catecholamines. Pheochromocytomas usually originate from the adrenal medulla but may also develop from chromaffin cells in or about sympathetic ganglia. A common symptom of pheochromocytoma is hypertension owing to release of catecholamines.	SNOMEDCT_US:85583005|SNOMEDCT_US:399343007|MSH:D010673|UMLS:C0031511|SNOMEDCT_US:302835009|NCIT:C3326	hp.json	Chromaffin tumors|Chromaffin tumours	http://purl.obolibrary.org/obo/HP_0002666		
GO:0003379	biolink:BiologicalProcess	establishment of cell polarity involved in gastrulation cell migration	The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.		hp.json		http://purl.obolibrary.org/obo/GO_0003379		
HP:0002638	biolink:PhenotypicFeature	Superficial thrombophlebitis	Inflammation of a superficial vein associated with venous thrombosis (blood clot formation within the vein).	SNOMEDCT_US:2477008|UMLS:C1510431	hp.json		http://purl.obolibrary.org/obo/HP_0002638		
HP:0002639	biolink:PhenotypicFeature	Budd-Chiari syndrome	Budd-Chiari syndrome (BCS) is caused by obstruction of hepatic venous outflow at any level from the small hepatic veins to the junction of the inferior vena cava (IVC) with the right atrium, 1 and occurs in 1/100,000 of the general population worldwide. The most common presentation is with ascites, but can range from fulminant hepatic failure (FHF) to asymptomatic forms. Obstruction of hepatic venous outflow is mainly caused by primary intravascular thrombosis, which can occur suddenly or be repeated over time, accompanied by some revascularization, accounting for the variable parenchymal hepatic damage and histologic presentation. Budd-Chiari syndrome is thus a disease, but since it occurs as a manifestation of several other diseases, this term is kept for the present for convenience.	UMLS:C0856761|MSH:D006502|SNOMEDCT_US:82385007	hp.json		http://purl.obolibrary.org/obo/HP_0002639		
HP:0002636	biolink:PhenotypicFeature	Dilatation of an abdominal artery	Abnormal outpouching or sac-like dilatation in an artery that originates from the abdominal aorta.	UMLS:C4025694	hp.json	Aneurysm of an abdominal artery	http://purl.obolibrary.org/obo/HP_0002636		
HP:0002637	biolink:PhenotypicFeature	Cerebral ischemia	Restriction of arterial blood supply to the brain associated with insufficient oxygenation to support the metabolic requirements of the tissue.	MSH:D002545|UMLS:C0917798|SNOMEDCT_US:287731003|UMLS:C0007786|SNOMEDCT_US:389100007	hp.json	Brain ischemia|Disruption of blood oxygen supply to brain|Cerebrovascular ischemia	http://purl.obolibrary.org/obo/HP_0002637		
GO:0003371	biolink:BiologicalProcess	establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration	Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.		hp.json		http://purl.obolibrary.org/obo/GO_0003371		
HP:0002630	biolink:PhenotypicFeature	Fat malabsorption	Abnormality of the absorption of fat from the gastrointestinal tract.	UMLS:C0554103|SNOMEDCT_US:197494007	hp.json		http://purl.obolibrary.org/obo/HP_0002630		
HP:0002631	biolink:PhenotypicFeature	obsolete Dilatation of ascending aorta			hp.json		http://purl.obolibrary.org/obo/HP_0002631		
HP:0002634	biolink:PhenotypicFeature	Arteriosclerosis	Sclerosis (hardening) of the arteries with increased thickness of the wall of arteries as well as increased stiffness and a loss of elasticity.	SNOMEDCT_US:72092001|UMLS:C4280568|UMLS:C0003850|MSH:D001161|SNOMEDCT_US:107671003|SNOMEDCT_US:28960008	hp.json	Hardened artery wall	http://purl.obolibrary.org/obo/HP_0002634		
HP:0002635	biolink:PhenotypicFeature	Type IV atherosclerotic lesion	In type IV atherosclerotic lesions a dense accumulation of extracellular lipid occupies an extensive but well-defined region of the intima. This type of extracellular lipid accumulation is known as the lipid core. A fibrous tissue increase is not a feature, and complications such as defects of the lesion surface and thrombosis are not present. The type IV lesion is also known as atheroma. Type IV is the first lesion considered advanced in this classification because of the severe intimal disorganization caused by the lipid core. The characteristic core appears to develop from an increase and the consequent confluence of the small isolated pools of extracellular lipid that characterize type III lesions. The increase in lipid is believed to result from continued insudation from the plasma. Type IV lesions, when they first appear in younger people, are found in the same locations as adaptive intimal thickenings of the eccentric type. Thus, atheroma is, at least initially, an eccentric lesion.	SNOMEDCT_US:38716007|UMLS:C0004153|MSH:D050197	hp.json	Atheromatosis	http://purl.obolibrary.org/obo/HP_0002635		
HP:0002632	biolink:PhenotypicFeature	Low-to-normal blood pressure		UMLS:C1866500	hp.json	Low-to-normal BP|Low-to-normal blood pressure	http://purl.obolibrary.org/obo/HP_0002632		
HP:0002633	biolink:PhenotypicFeature	Vasculitis	Inflammation of blood vessel.	UMLS:C0042384|SNOMEDCT_US:31996006|MSH:D014657	hp.json	Angiitis|Inflammation of blood vessel	http://purl.obolibrary.org/obo/HP_0002633		
GO:0030990	biolink:CellularComponent	intraciliary transport particle	A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.		hp.json	IFT complex|intraflagellar transport particle|intraflagellar transport complex	http://purl.obolibrary.org/obo/GO_0030990		goslim_pir
HP:0002647	biolink:PhenotypicFeature	Aortic dissection	Aortic dissection refers to a tear in the intimal layer of the aorta causing a separation between the intima and the medial layers of the aorta.	UMLS:C0340643|SNOMEDCT_US:308546005	hp.json	Tear in inner wall of large artery that carries blood away from heart	http://purl.obolibrary.org/obo/HP_0002647		
HP:0002648	biolink:PhenotypicFeature	obsolete Abnormality of calvarial morphology			hp.json		http://purl.obolibrary.org/obo/HP_0002648		
GO:0003380	biolink:BiologicalProcess	establishment or maintenance of cytoskeleton polarity involved in gastrulation	Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation.		hp.json		http://purl.obolibrary.org/obo/GO_0003380		
GO:0003382	biolink:BiologicalProcess	epithelial cell morphogenesis	The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.		hp.json		http://purl.obolibrary.org/obo/GO_0003382		
GO:0003381	biolink:BiologicalProcess	epithelial cell morphogenesis involved in gastrulation	The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.		hp.json		http://purl.obolibrary.org/obo/GO_0003381		
HP:0002641	biolink:PhenotypicFeature	Peripheral thrombosis		UMLS:C1849749	hp.json	Peripheral blood clot	http://purl.obolibrary.org/obo/HP_0002641		
HP:0002642	biolink:PhenotypicFeature	Arteriovenous fistulas of celiac and mesenteric vessels		UMLS:C1857693	hp.json	Arteriovenous fistulas of coeliac and mesenteric vessels	http://purl.obolibrary.org/obo/HP_0002642		
HP:0002640	biolink:PhenotypicFeature	Hypertension associated with pheochromocytoma	A type of hypertension associated with pheochromocytoma.	UMLS:C4025693	hp.json		http://purl.obolibrary.org/obo/HP_0002640		
HP:0002645	biolink:PhenotypicFeature	Wormian bones	The presence of extra bones within a cranial suture. Wormian bones are irregular isolated bones which appear in addition to the usual centers of ossification of the cranium.	SNOMEDCT_US:113194005|UMLS:C0222716	hp.json	Islands of bone within cranial sutures|Extra bones within cranial sutures|Intrasutural bones|Intra sutural bones	http://purl.obolibrary.org/obo/HP_0002645		hposlim_core
HP:0002643	biolink:PhenotypicFeature	Neonatal respiratory distress	Respiratory difficulty as newborn.	UMLS:C0852283	hp.json	Respiratory distress, neonatal|Newborn respiratory distress|Infantile respiratory distress|Neonatal respiratory distress	http://purl.obolibrary.org/obo/HP_0002643		
HP:0002644	biolink:PhenotypicFeature	Abnormal pelvic girdle bone morphology	An abnormality of the bony pelvic girdle, which is a ring of bones connecting the vertebral column to the femurs.	UMLS:C4020847	hp.json	Abnormality of pelvic girdle bone morphology|Abnormal shape of pelvic girdle bone|Abnormality of the pelvic girdle	http://purl.obolibrary.org/obo/HP_0002644		
HP:0012022	biolink:PhenotypicFeature	Congenital portosystemic venous shunt	A congenital defect of the vasculature such that there is a shunt (by-pass) of blood directly from the portal vein to the vena cava (i.e., the blood from the portal vein is not filtered through the liver).	SNOMEDCT_US:253330006|MSH:C562830|UMLS:C0344688	hp.json		http://purl.obolibrary.org/obo/HP_0012022		
HP:0012023	biolink:PhenotypicFeature	Galactosuria	Elevated concentration of galactose in the urine.	SNOMEDCT_US:71690006|UMLS:C0268157	hp.json	Increased urinary galactose level	http://purl.obolibrary.org/obo/HP_0012023		
HP:0012024	biolink:PhenotypicFeature	Hypergalactosemia	Elevated concentration of galactose in the blood.	UMLS:C4023071|SNOMEDCT_US:190745006|UMLS:C0016952|MSH:D005693|SNOMEDCT_US:190749000	hp.json	Galactosemia	http://purl.obolibrary.org/obo/HP_0012024		
HP:0012025	biolink:PhenotypicFeature	Abnormal circulating ornithine concentration	Deviation from the normal concentration of ornithine in the blood circulation.	UMLS:C4023070	hp.json		http://purl.obolibrary.org/obo/HP_0012025		
HP:0012026	biolink:PhenotypicFeature	Hyperornithinemia	Increased concentration of ornithine in the blood.	UMLS:C0599035|SNOMEDCT_US:33985005|MSH:D015799|SNOMEDCT_US:276426004	hp.json	High blood ornithine levels	http://purl.obolibrary.org/obo/HP_0012026		
GO:0003354	biolink:BiologicalProcess	negative regulation of cilium movement	Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.		hp.json	negative regulation of flagellum movement|negative regulation of microtubule-based flagellum movement	http://purl.obolibrary.org/obo/GO_0003354		
HP:0012027	biolink:PhenotypicFeature	Laryngeal edema	An abnormal accumulation of fluid and swelling in the tissues of the larynx.	MSH:D007819|UMLS:C0023052|SNOMEDCT_US:51599000	hp.json	Laryngeal oedema	http://purl.obolibrary.org/obo/HP_0012027		
HP:0012028	biolink:PhenotypicFeature	Hepatocellular adenoma	A benign tumor of the liver of presumably epithelial origin.	MSH:D018248|MPATH:353|SNOMEDCT_US:424263008|SNOMEDCT_US:78058005|UMLS:C0206669	hp.json	Hepatic adenoma|Liver cell adenoma	http://purl.obolibrary.org/obo/HP_0012028		
HP:0012029	biolink:PhenotypicFeature	Abnormal urine hormone level	An abnormal concentration of a hormone in the urine.	UMLS:C4023069	hp.json	Abnormality of urine hormone level	http://purl.obolibrary.org/obo/HP_0012029		
GO:0003353	biolink:BiologicalProcess	positive regulation of cilium movement	Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.		hp.json	positive regulation of flagellar movement|positive regulation of flagellum movement|positive regulation of microtubule-based flagellum movement	http://purl.obolibrary.org/obo/GO_0003353		
GO:0003352	biolink:BiologicalProcess	regulation of cilium movement	Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.		hp.json	regulation of flagellum movement|regulation of microtubule-based flagellum movement|regulation of flagellar movement	http://purl.obolibrary.org/obo/GO_0003352		
HP:0012020	biolink:PhenotypicFeature	Right aortic arch	Aorta descends on right instead of on the left.	SNOMEDCT_US:111321007|UMLS:C0035615|Fyler:2720|SNOMEDCT_US:244229003	hp.json	Right-sided aortic arch	http://purl.obolibrary.org/obo/HP_0012020		
HP:0012021	biolink:PhenotypicFeature	Persistent patent ductus venosus	Persistence of blood flow through the ductus venosus for longer than the normal time after birth.	UMLS:C4023072	hp.json		http://purl.obolibrary.org/obo/HP_0012021		
HP:0002696	biolink:PhenotypicFeature	Abnormal parietal bone morphology	Any abnormality of the parietal bone of the skull.	UMLS:C4021834	hp.json	Abnormality of the parietal bone|Abnormality of the parietal bone of skull	http://purl.obolibrary.org/obo/HP_0002696		
HP:0000033	biolink:PhenotypicFeature	Ambiguous genitalia, male	Ambiguous genitalia in an individual with XY genetic gender.	UMLS:C4021823	hp.json	Ambiguous genitalia in males	http://purl.obolibrary.org/obo/HP_0000033		
HP:0002697	biolink:PhenotypicFeature	Parietal foramina	The presence of symmetrical and circular openings (foramina) in the parietal bone ranging in size from a few millimeters to several centimeters wide.	UMLS:C0222706|UMLS:C4280556|SNOMEDCT_US:11240000|SNOMEDCT_US:29307005	hp.json	Persistent foramina of the parietal bones|Holes in parietal bones|Symmetrical, oval defects in the parietal bone|Symmetrical, oval parietal bone defects|Openings in parietal bones	http://purl.obolibrary.org/obo/HP_0002697		
HP:0000032	biolink:PhenotypicFeature	Abnormality of male external genitalia	An abnormality of male external genitalia.	UMLS:C4025897	hp.json		http://purl.obolibrary.org/obo/HP_0000032		
HP:0002694	biolink:PhenotypicFeature	Sclerosis of skull base	Increased bone density of the skull base without significant changes in bony contour.	UMLS:C1851714|UMLS:C4072848|UMLS:C4072847	hp.json	Sclerosis of the skull base|Sclerosis of cranial base|Hyperossification of skull base|HyperMineralization of skull base|Marked sclerosis of skull base|Sclerotic skull base|Dense bone of skull base|Hyperostosis of skull base|HyperCalcification of skull base	http://purl.obolibrary.org/obo/HP_0002694		
HP:0000035	biolink:PhenotypicFeature	Abnormal testis morphology	An anomaly of the testicle (the male gonad).	SNOMEDCT_US:55631001|UMLS:C0266423	hp.json	Abnormality of the testis|Anomaly of the testes	http://purl.obolibrary.org/obo/HP_0000035		
HP:0002695	biolink:PhenotypicFeature	obsolete Symmetrical, oval parietal bone defects			hp.json		http://purl.obolibrary.org/obo/HP_0002695		
HP:0000034	biolink:PhenotypicFeature	Hydrocele testis	Accumulation of clear fluid in the between the layers of membrane (tunica vaginalis) surrounding the testis.	UMLS:C1720771|SNOMEDCT_US:26614003|SNOMEDCT_US:386152007|MSH:D006848|SNOMEDCT_US:55434001	hp.json	Hydrocele|Testicular hydrocele	http://purl.obolibrary.org/obo/HP_0000034		
HP:0000037	biolink:PhenotypicFeature	Male pseudohermaphroditism	Hermaphroditism refers to a discrepancy between the morphology of the gonads and that of the external genitalia. In male pseudohermaphroditism, the genotype is male (XY) and the external genitalia are imcompletely virilized, ambiguous, or complete female. If gonads are present, they are testes.	MSH:D058490|UMLS:C0238395|SNOMEDCT_US:111332007	hp.json		http://purl.obolibrary.org/obo/HP_0000037		
HP:0000036	biolink:PhenotypicFeature	Abnormal penis morphology	Abnormality of the male external sex organ.	UMLS:C4025896	hp.json	Abnormality of the penis	http://purl.obolibrary.org/obo/HP_0000036		
HP:0000039	biolink:PhenotypicFeature	Epispadias	Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias.	SNOMEDCT_US:406477003|UMLS:C0563449	hp.json		http://purl.obolibrary.org/obo/HP_0000039		
HP:0002699	biolink:PhenotypicFeature	Abnormal foramen magnum morphology	Any abnormality of the foramen magnum.	UMLS:C4025687	hp.json	Abnormality of the foramen magnum	http://purl.obolibrary.org/obo/HP_0002699		hposlim_core
HP:0002692	biolink:PhenotypicFeature	Hypoplastic facial bones		UMLS:C4229090|UMLS:C4280558|UMLS:C4280557|UMLS:C1846438|UMLS:C4280268	hp.json	Underdevelopment of facial bones|Underdevelopment of facial skeleton|Small facial bones|Hypoplasia of facial skeleton|Flattening of facial skeleton|Hypotrophic facial bones|Hypotrophic facial skeleton|Decreased size of facial bones|Decreased size of facial skeleton|Flattening of facial bones|Small facial skeleton	http://purl.obolibrary.org/obo/HP_0002692		
HP:0002693	biolink:PhenotypicFeature	Abnormality of the skull base	An abnormality of the base of the skull, which forms the floor of the cranial cavity and separates the brain from other facial structures. The skull base is made up of five bones: the ethmoid, sphenoid, occipital, paired frontal, and paired parietal bones, and is subdivided into 3 regions: the anterior, middle, and posterior cranial fossae. The petro-occipital fissure subdivides the middle cranial fossa into 1 central component and 2 lateral components.	UMLS:C4025688	hp.json	Abnormality of cranial base|Abnormality of the skull base	http://purl.obolibrary.org/obo/HP_0002693		
HP:0002690	biolink:PhenotypicFeature	Large sella turcica	An abnormal enlargement of the sella turcica.	UMLS:C4072846|UMLS:C4072845|UMLS:C1843677	hp.json	Hyperplasia of sella turcica|Large pituitary fossa|Large hypophysial fossa|Hyperplasia of pituitary fossa|Hyperplasia of hypophysial fossa|Big sella turcica|Prominent sella turcica|Enlarged sella turcica	http://purl.obolibrary.org/obo/HP_0002690		hposlim_core
HP:0000031	biolink:PhenotypicFeature	Epididymitis	The presence of inflammation of the epididymis.	MSH:D004823|SNOMEDCT_US:31070006|UMLS:C0014534	hp.json		http://purl.obolibrary.org/obo/HP_0000031		
HP:0002691	biolink:PhenotypicFeature	Platybasia	A developmental malformation of the occipital bone and upper end of the cervical spine, in which the latter appears to have pushed the floor of the occipital bone upward such that there is an abnormal flattening of the skull base.	UMLS:C0032209|SNOMEDCT_US:86587003|MSH:D010985	hp.json	Obtuse basal angle of skull base|Increased basal angle of skull base|Flattening of the skull base	http://purl.obolibrary.org/obo/HP_0002691		hposlim_core
HP:0000030	biolink:PhenotypicFeature	Testicular gonadoblastoma	The presence of a gonadoblastoma of the testis.	UMLS:C1515283|NCIT:C3754	hp.json	Gonadoblastoma, male	http://purl.obolibrary.org/obo/HP_0000030		
HP:0012011	biolink:PhenotypicFeature	EEG with occipital focal spike waves	EEG with focal sharp transient waves in the occipital region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.	UMLS:C4023080	hp.json		http://purl.obolibrary.org/obo/HP_0012011		
HP:0012012	biolink:PhenotypicFeature	EEG with parietal focal spike waves	EEG with focal sharp transient waves in the parietal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.	UMLS:C4023079	hp.json		http://purl.obolibrary.org/obo/HP_0012012		
HP:0012013	biolink:PhenotypicFeature	EEG with temporal focal spike waves	EEG with focal sharp transient waves in the temporal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.	UMLS:C4023078	hp.json		http://purl.obolibrary.org/obo/HP_0012013		
HP:0012014	biolink:PhenotypicFeature	EEG with central focal spikes	EEG with focal sharp transient waves of a duration less than 80 msec in the central region.	UMLS:C4023077	hp.json		http://purl.obolibrary.org/obo/HP_0012014		
HP:0012015	biolink:PhenotypicFeature	EEG with frontal focal spikes	EEG with focal sharp transient waves of a duration less than 80 msec in the frontal region.	UMLS:C4023076	hp.json		http://purl.obolibrary.org/obo/HP_0012015		
GO:0003365	biolink:BiologicalProcess	establishment of cell polarity involved in ameboidal cell migration	The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.		hp.json		http://purl.obolibrary.org/obo/GO_0003365		
HP:0012016	biolink:PhenotypicFeature	EEG with occipital focal spikes	EEG with focal sharp transient waves of a duration less than 80 msec in the occipital region.	UMLS:C4023075	hp.json		http://purl.obolibrary.org/obo/HP_0012016		
HP:0012017	biolink:PhenotypicFeature	EEG with parietal focal spikes	EEG with focal sharp transient waves of a duration less than 80 msec in the parietal region.	UMLS:C4023074	hp.json		http://purl.obolibrary.org/obo/HP_0012017		
HP:0012018	biolink:PhenotypicFeature	EEG with temporal focal spikes	EEG with focal sharp transient waves of a duration less than 80 msec in the temporal region.	UMLS:C4023073	hp.json		http://purl.obolibrary.org/obo/HP_0012018		
GO:0003360	biolink:BiologicalProcess	brainstem development	The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.		hp.json		http://purl.obolibrary.org/obo/GO_0003360		
HP:0012010	biolink:PhenotypicFeature	EEG with frontal focal spike waves	EEG with focal sharp transient waves in the frontal region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.	UMLS:C4023081	hp.json		http://purl.obolibrary.org/obo/HP_0012010		
HP:0000044	biolink:PhenotypicFeature	Hypogonadotropic hypogonadism	Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH).	UMLS:C0271623|SNOMEDCT_US:33927004|MSH:D007006|UMLS:C3489396	hp.json	Isolated hypogonadotropic hypogonadism|Low gonadotropins (secondary hypogonadism)|Hypogonadotrophic hypogonadism	http://purl.obolibrary.org/obo/HP_0000044		
HP:0000046	biolink:PhenotypicFeature	Small scrotum	Apparently small scrotum for age.	UMLS:C0431659|SNOMEDCT_US:204912007	hp.json	Scrotal hypoplasia|Hypoplastic scrotum|Smaller than typical growth of scrotum|Underdeveloped scrotum	http://purl.obolibrary.org/obo/HP_0000046		
HP:0000045	biolink:PhenotypicFeature	Abnormality of the scrotum		UMLS:C4025895	hp.json		http://purl.obolibrary.org/obo/HP_0000045		
HP:0000048	biolink:PhenotypicFeature	Bifid scrotum	Midline indentation or cleft of the scrotum.	SNOMEDCT_US:236780002|UMLS:C0341787	hp.json	Cleft of scrotum|Scrotal cleft	http://purl.obolibrary.org/obo/HP_0000048		
HP:0000047	biolink:PhenotypicFeature	Hypospadias	Abnormal position of urethral meatus on the ventral penile shaft (underside) characterized by displacement of the urethral meatus from the tip of the glans penis to the ventral surface of the penis, scrotum, or perineum.	UMLS:C1691215|Fyler:4504|SNOMEDCT_US:204888000	hp.json	Hypospadia	http://purl.obolibrary.org/obo/HP_0000047		
HP:0000049	biolink:PhenotypicFeature	Shawl scrotum	Superior margin of the scrotum superior to the base of the penis.	UMLS:C1858539	hp.json	Scrotum surrounds penis|Overriding scrotum	http://purl.obolibrary.org/obo/HP_0000049		
HP:0012019	biolink:PhenotypicFeature	Lens luxation	Complete dislocation of the lens of the eye.	MSH:D007906|UMLS:C0023309	hp.json	Dislocated lens|Dislocated lenses	http://purl.obolibrary.org/obo/HP_0012019		
HP:0000040	biolink:PhenotypicFeature	Long penis	Penile length more than 2 SD above the mean for age.	SNOMEDCT_US:88673001|UMLS:C0269011	hp.json	Enlarged penis|Long penis	http://purl.obolibrary.org/obo/HP_0000040		
HP:0000042	biolink:PhenotypicFeature	Absent external genitalia	Lack of external genitalia in a male or female individual.	UMLS:C1848869	hp.json	Absent external genitalia	http://purl.obolibrary.org/obo/HP_0000042		
HP:0000041	biolink:PhenotypicFeature	Chordee	Ventral, lateral, or ventrolateral bowing of the shaft and glans penis of more than 30 degrees.	UMLS:C0221182|SNOMEDCT_US:4287008	hp.json		http://purl.obolibrary.org/obo/HP_0000041		
HP:0012000	biolink:PhenotypicFeature	EEG with generalized spikes	EEG with generalized sharp transient waves of a duration less than 80 msec.	UMLS:C2206531	hp.json	EEG with generalised spikes	http://purl.obolibrary.org/obo/HP_0012000		
HP:0012001	biolink:PhenotypicFeature	EEG with generalized polyspikes	EEG with repetitive generalized sharp transient waves of a duration less than 80 msec.	UMLS:C4023088	hp.json	EEG with generalised polyspikes	http://purl.obolibrary.org/obo/HP_0012001		
HP:0012002	biolink:PhenotypicFeature	Experiential epileptic aura	Affective, mnemonic or composite perceptual auras with subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context.	UMLS:C4023087	hp.json	Experiential auras|Experiential aura	http://purl.obolibrary.org/obo/HP_0012002		
HP:0012003	biolink:PhenotypicFeature	Affective epileptic aura	Affective auras with subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context.	UMLS:C4023086	hp.json	Affective auras|Affective aura|Emotional aura	http://purl.obolibrary.org/obo/HP_0012003		
HP:0012004	biolink:PhenotypicFeature	Focal cognitive seizure with deja vu/jamais vu	A focal cognitive seizure characterized by memory phenomena such as feelings of familiarity (deja vu) and unfamiliarity (jamais vu) as the initial semiological manifestation.	UMLS:C4023085	hp.json	Mnemonic auras|Mnemonic aura	http://purl.obolibrary.org/obo/HP_0012004		
GO:0030952	biolink:BiologicalProcess	establishment or maintenance of cytoskeleton polarity	Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.		hp.json	cytoskeleton polarization	http://purl.obolibrary.org/obo/GO_0030952		
GO:0005996	biolink:BiologicalProcess	monosaccharide metabolic process	The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.		hp.json	monosaccharide metabolism	http://purl.obolibrary.org/obo/GO_0005996		
GO:0003333	biolink:BiologicalProcess	amino acid transmembrane transport	The process in which an amino acid is transported across a membrane.		hp.json	amino acid membrane transport	http://purl.obolibrary.org/obo/GO_0003333		
HP:0012005	biolink:PhenotypicFeature	Deja vu aura	A subjective feeling that an experience which is occurring for the first time has been experienced before.	SNOMEDCT_US:313005|MSH:D003690|UMLS:C0011194	hp.json	Deja vu	http://purl.obolibrary.org/obo/HP_0012005		
HP:0012006	biolink:PhenotypicFeature	Jamais vu aura	A subjective feeling that an experience which has occurred before is being experienced for the first time.	UMLS:C0233803|SNOMEDCT_US:28249008	hp.json	Jamais vu	http://purl.obolibrary.org/obo/HP_0012006		
HP:0012007	biolink:PhenotypicFeature	Focal cognitive seizure with hallucination	A focal cognitive seizure characterized by hallucination as the initial semiological manifestation.	UMLS:C4023084	hp.json	Hallucinatory auras|Hallucinatory aura	http://purl.obolibrary.org/obo/HP_0012007		
GO:0030951	biolink:BiologicalProcess	establishment or maintenance of microtubule cytoskeleton polarity	Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.		hp.json		http://purl.obolibrary.org/obo/GO_0030951		
GO:0003334	biolink:BiologicalProcess	keratinocyte development	The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0003334		
HP:0000019	biolink:PhenotypicFeature	Urinary hesitancy	Difficulty in beginning the process of urination.	UMLS:C0152032|SNOMEDCT_US:5972002	hp.json	Difficulty with flow	http://purl.obolibrary.org/obo/HP_0000019		
HP:0000011	biolink:PhenotypicFeature	Neurogenic bladder	A type of bladder dysfunction caused by neurologic damage. Neurogenic bladder can be flaccid or spastic. Common manifestatios of neurogenic bladder are overflow incontinence, frequency, urgency, urge incontinence, and retention.	UMLS:C0005697|SNOMEDCT_US:398064005|MSH:D001750|SNOMEDCT_US:397732007	hp.json	Lack of bladder control due to nervous system injury	http://purl.obolibrary.org/obo/HP_0000011		
HP:0000010	biolink:PhenotypicFeature	Recurrent urinary tract infections	Repeated infections of the urinary tract.	UMLS:C0262655|SNOMEDCT_US:197927001	hp.json	Repeated bladder infections|Repeated urinary tract infections|Frequent urinary tract infections|Urinary tract infections, recurrent|Recurrent UTIs|Urinary tract infections	http://purl.obolibrary.org/obo/HP_0000010		
HP:0000013	biolink:PhenotypicFeature	Hypoplasia of the uterus	Underdevelopment of the uterus.	SNOMEDCT_US:35850006|UMLS:C0266399	hp.json	Hypoplastic uterus|Rudimentary uterus|Underdeveloped uterus|Small uterus	http://purl.obolibrary.org/obo/HP_0000013		
HP:0002672	biolink:PhenotypicFeature	Gastrointestinal carcinoma		UMLS:C0151544	hp.json	GI carcinoma	http://purl.obolibrary.org/obo/HP_0002672		
HP:0002673	biolink:PhenotypicFeature	Coxa valga	Coxa valga is a deformity of the hip in which the angle between the femoral shaft and the femoral neck is increased compared to age-adjusted values (about 150 degrees in newborns gradually reducing to 120-130 degrees in adults).	UMLS:C3549698|UMLS:C0239137|MSH:D060906|SNOMEDCT_US:299236004	hp.json	Coxa valga deformity|Valgus hip	http://purl.obolibrary.org/obo/HP_0002673		
HP:0000012	biolink:PhenotypicFeature	Urinary urgency	Urge incontinence is the strong, sudden need to urinate.	UMLS:C0085606|SNOMEDCT_US:75088002|UMLS:C4020898|UMLS:C3544092	hp.json	Urgency frequency syndrome|Urinary urgency|Overactive bladder syndrome|Overactive bladder	http://purl.obolibrary.org/obo/HP_0000012		
HP:0000015	biolink:PhenotypicFeature	Bladder diverticulum	Diverticulum (sac or pouch) in the wall of the urinary bladder.	SNOMEDCT_US:197866008|UMLS:C0156273|MSH:C562406	hp.json	Bladder diverticula	http://purl.obolibrary.org/obo/HP_0000015		
HP:0002678	biolink:PhenotypicFeature	Skull asymmetry		UMLS:C4280563|UMLS:C4280562|SNOMEDCT_US:248372000|UMLS:C0424690	hp.json	Unequal skull shape|Skull asymmetry|Malformation of skull shape|Asymmetry of skull|Uneven skull shape|Abnormality of skull shape	http://purl.obolibrary.org/obo/HP_0002678		
HP:0000014	biolink:PhenotypicFeature	Abnormality of the bladder	An abnormality of the urinary bladder.	UMLS:C0149632	hp.json		http://purl.obolibrary.org/obo/HP_0000014		
HP:0002679	biolink:PhenotypicFeature	Abnormal sella turcica morphology	Abnormality of the sella turcica, a saddle-shaped depression in the sphenoid bone at the base of the human skull.	UMLS:C4021754|UMLS:C4072839	hp.json	Abnormality of the sella turcica|Anomaly of the sella turcica|Anomaly of the pituitary fossa|Anomaly of the hypophysial fossa|Abnormality of the pituitary fossa|Abnormality of the hypophysial fossa	http://purl.obolibrary.org/obo/HP_0002679		hposlim_core
HP:0002676	biolink:PhenotypicFeature	Cloverleaf skull	Trilobar skull configuration when viewed from the front or behind.	UMLS:C4280564|UMLS:C1860050	hp.json	Trilobar cranium shape|Kleeblattschaedel|Cloverleaf skull shape|Trilobar skull shape|Cloverleaf cranium shape	http://purl.obolibrary.org/obo/HP_0002676		hposlim_core
HP:0000017	biolink:PhenotypicFeature	Nocturia	Abnormally increased production of urine during the night leading to an unusually frequent need to urinate.	UMLS:C0028734|SNOMEDCT_US:139394000|MSH:D053158	hp.json	Nycturia	http://purl.obolibrary.org/obo/HP_0000017		
HP:0000016	biolink:PhenotypicFeature	Urinary retention	Inability to completely empty the urinary bladder during the process of urination.	SNOMEDCT_US:130951007|MSH:D016055|SNOMEDCT_US:449491000124101|SNOMEDCT_US:267064002|UMLS:C0080274	hp.json	Increased post-void residual urine volume	http://purl.obolibrary.org/obo/HP_0000016		
HP:0002677	biolink:PhenotypicFeature	Small foramen magnum	An abnormal narrowing of the foramen magnum.	UMLS:C4072838|UMLS:C1861217|SNOMEDCT_US:444879009|UMLS:C1535953	hp.json	Little foramen magnum|Stenosis of foramen magnum|Foramen magnum stenosis|Hypoplasia of foramen magnum|Narrow foramen magnum	http://purl.obolibrary.org/obo/HP_0002677		hposlim_core
HP:0012008	biolink:PhenotypicFeature	Focal cognitive seizure with illusion	A focal cognitive seizure characterized by an alteration of actual perception involving visual, auditory, somatosensory, olfactory, and/or gustatory phenomena as the initial semiological manifestation.	UMLS:C4023083	hp.json	Illusory aura|Illusory auras	http://purl.obolibrary.org/obo/HP_0012008		
HP:0012009	biolink:PhenotypicFeature	EEG with central focal spike waves	EEG with focal sharp transient waves in the central region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.	UMLS:C4023082	hp.json		http://purl.obolibrary.org/obo/HP_0012009		
HP:0002671	biolink:PhenotypicFeature	Basal cell carcinoma	The presence of a basal cell carcinoma of the skin.	MSH:D002280|NCIT:C2921|SNOMEDCT_US:275265005|UMLS:C1862314|SNOMEDCT_US:254701007|SNOMEDCT_US:1338007|UMLS:C0007117	hp.json	Basal cell epithelioma|Basal cell carcinomas|Basal cell nevus|Basalioma	http://purl.obolibrary.org/obo/HP_0002671		
GO:0003348	biolink:BiologicalProcess	cardiac endothelial cell differentiation	The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.		hp.json		http://purl.obolibrary.org/obo/GO_0003348		
GO:0003344	biolink:BiologicalProcess	pericardium morphogenesis	The process in which the anatomical structure of the pericardium is generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0003344		
GO:0003343	biolink:BiologicalProcess	septum transversum development	The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme.		hp.json		http://purl.obolibrary.org/obo/GO_0003343		
HP:0000029	biolink:PhenotypicFeature	Testicular atrophy	Wasting (atrophy) of the testicle (the male gonad) manifested by a decrease in size and potentially by a loss of fertility.	SNOMEDCT_US:17585008|UMLS:C0156312	hp.json	Testicular degeneration	http://purl.obolibrary.org/obo/HP_0000029		
GO:0003342	biolink:BiologicalProcess	proepicardium development	The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.		hp.json		http://purl.obolibrary.org/obo/GO_0003342		
GO:0003341	biolink:BiologicalProcess	cilium movement	The directed, self-propelled movement of a cilium.		hp.json	ciliary motility|flagellar motility|flagellar movement|microtubule-based flagellum movement|cilium beating|flagellum movement	http://purl.obolibrary.org/obo/GO_0003341		
HP:0000022	biolink:PhenotypicFeature	Abnormal male internal genitalia morphology	An abnormality of the male internal genitalia.	UMLS:C4025899	hp.json		http://purl.obolibrary.org/obo/HP_0000022		
HP:0002686	biolink:PhenotypicFeature	Prenatal maternal abnormality		UMLS:C4025690	hp.json	Maternal health problem	http://purl.obolibrary.org/obo/HP_0002686		
HP:0000021	biolink:PhenotypicFeature	Megacystis	Dilatation of the bladder postnatally.	UMLS:C1855311|MSH:C536139	hp.json		http://purl.obolibrary.org/obo/HP_0000021		
HP:0000024	biolink:PhenotypicFeature	Prostatitis	The presence of inflammation of the prostate.	UMLS:C0033581|SNOMEDCT_US:9713002|MSH:D011472	hp.json	Inflammation of the prostate	http://purl.obolibrary.org/obo/HP_0000024		
HP:0002683	biolink:PhenotypicFeature	Abnormal calvaria morphology	Abnormality of the morphology (structure) of the calvaria (skullcap), that is, of that part of the skull that is made up of the superior portions of the frontal bone, occipital bone, and parietal bones and covers the cranial cavity that contains the brain.	UMLS:C4280561|UMLS:C4025691	hp.json	Abnormality of cranial vault|Abnormality of cranium|Abnormality of calvarium|Abnormality of the calvaria|Abnormality of the skullcap|Abnormality of the shape of calvarium|Abnormality of the skull cap	http://purl.obolibrary.org/obo/HP_0002683		
HP:0002684	biolink:PhenotypicFeature	Thickened calvaria	The presence of an abnormally thick calvaria.	UMLS:C4280560|UMLS:C1858452	hp.json	Thickening of the calvaria|Thick calvarium|Increased thickness of cranial vault|Thick calvaria|Increased thickness of cranium|Increased thickness of calvarium|Increased calvarial thickness|Calvarial thickening|Thickened cranial vault|Thickened calvarium|Calvarium thickened|Thickened skull cap|Thickened cranium|Increased thickness of calvaria|Increased thickness of skull cap	http://purl.obolibrary.org/obo/HP_0002684		
HP:0000023	biolink:PhenotypicFeature	Inguinal hernia	Protrusion of the contents of the abdominal cavity through the inguinal canal.	MEDDRA:10022016|UMLS:C0019294|SNOMEDCT_US:396232000|MSH:D006552	hp.json		http://purl.obolibrary.org/obo/HP_0000023		hposlim_core
HP:0000026	biolink:PhenotypicFeature	Male hypogonadism	Decreased functionality of the male gonad, i.e., of the testis, with reduced spermatogenesis or testosterone synthesis.	SNOMEDCT_US:48723006|UMLS:C0151721|MSH:D005058	hp.json	Decreased function of male gonad	http://purl.obolibrary.org/obo/HP_0000026		
HP:0002689	biolink:PhenotypicFeature	Absent paranasal sinuses	Aplasia of the paranasal sinuses.	UMLS:C3804986|UMLS:C1857131|UMLS:C4072844	hp.json	Missing sinuses|Absence of paranasal sinuses|Aplasia of paranasal sinuses|Missing paranasal sinuses	http://purl.obolibrary.org/obo/HP_0002689		
HP:0000025	biolink:PhenotypicFeature	Functional abnormality of male internal genitalia		UMLS:C4025898	hp.json		http://purl.obolibrary.org/obo/HP_0000025		
HP:0002687	biolink:PhenotypicFeature	Abnormality of frontal sinus	An abnormality of the frontal sinus, one of the mucosa-lined, normally air-filled paranasal sinuses of the bones of the skull. The frontal sinus is located within the frontal bone.	UMLS:C4025689	hp.json	Abnormality of the forehead sinus|Abnormality of sinus frontalis	http://purl.obolibrary.org/obo/HP_0002687		
HP:0000028	biolink:PhenotypicFeature	Cryptorchidism	Testis in inguinal canal. That is, absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum.	SNOMEDCT_US:204878001|UMLS:C0010417|MSH:D003456|Fyler:4493	hp.json	Undescended testes|Cryptorchism|Undescended testis	http://purl.obolibrary.org/obo/HP_0000028		
HP:0000027	biolink:PhenotypicFeature	Azoospermia	Absence of any measurable level of sperm in his semen.	MSH:D053713|UMLS:C0004509|SNOMEDCT_US:48188009|SNOMEDCT_US:425558002	hp.json	Absent sperm in semen	http://purl.obolibrary.org/obo/HP_0000027		
HP:0002688	biolink:PhenotypicFeature	Absent frontal sinuses	Aplasia of frontal sinus.	UMLS:C4280559|UMLS:C1855669	hp.json	Absent frontal sinus|Absence of frontal sinuses|Aplasia sinus frontalis|Missing frontal sinus|Aplasia of frontal sinus	http://purl.obolibrary.org/obo/HP_0002688		hposlim_core
HP:0002681	biolink:PhenotypicFeature	Deformed sella turcica		UMLS:C1846437	hp.json	Abnormal shape of pituitary fossa|Deformity of pituitary fossa|Malformation of pituitary fossa|Abnormal shape of hypophysial fossa|Malformation of hypophysial fossa|Deformity of hypophysial fossa|Abnormal shape of sella turcica|Malformation of sella turcica	http://purl.obolibrary.org/obo/HP_0002681		
HP:0002682	biolink:PhenotypicFeature	Broad skull	Increased width of the skull.	SNOMEDCT_US:248374004|UMLS:C0424693	hp.json	Broad skull|Increased width of skull|Wide cranium|Broad cranium|Increased width of cranium|Wide skull	http://purl.obolibrary.org/obo/HP_0002682		
HP:0000020	biolink:PhenotypicFeature	Urinary incontinence	Loss of the ability to control the urinary bladder leading to involuntary urination.	MSH:D014549|UMLS:C0042024|SNOMEDCT_US:165232002	hp.json	Bladder incontinence|Loss of bladder control	http://purl.obolibrary.org/obo/HP_0000020		
HP:0002680	biolink:PhenotypicFeature	J-shaped sella turcica	A deformity of the sella turcica whereby the sella extends further anterior than normal such that the anterior clinoid process appears to overhang it, giving the appearance of the letter J on imaging of the skull.	UMLS:C1854718|UMLS:C4072842|UMLS:C4072841	hp.json	Hour glass shaped sella turcica|J-shaped pituitary fossa|Omega shaped sella turcica|J-shaped hypophysial fossa|J-shaped sella|Omega shaped pituitary fossa|Omega shaped hypophysial fossa|Hour glass shaped pituitary fossa|Hour glass shaped hypophysial fossa	http://purl.obolibrary.org/obo/HP_0002680		hposlim_core
HP:0012620	biolink:PhenotypicFeature	Cloacal abnormality	A developmental anomaly associated with the failure of rectum, vagina, and bladder to separate.	UMLS:C4022816	hp.json		http://purl.obolibrary.org/obo/HP_0012620		
HP:0012621	biolink:PhenotypicFeature	Persistent cloaca	Developmental anomaly in which the vagina, bladder, and rectum fuse resulting in a common channel.	UMLS:C0266225|SNOMEDCT_US:74829002	hp.json	Cloacogenic bladder	http://purl.obolibrary.org/obo/HP_0012621		
HP:0012622	biolink:PhenotypicFeature	Chronic kidney disease	Functional anomaly of the kidney persisting for at least three months.	SNOMEDCT_US:709044004|UMLS:C1561643|MSH:D051436|UMLS:C0748318	hp.json	Renal failure, progressive|Loss of renal function|Chronic kidney disease|Progressive renal failure|Renal insufficiency, progressive|Progressive renal insufficiency	http://purl.obolibrary.org/obo/HP_0012622		
HP:0012623	biolink:PhenotypicFeature	Stage 1 chronic kidney disease	A type of chronic kidney disease with normal or increased glomerular filtration rate (GFR at least 90 mL/min/1.73 m2).	SNOMEDCT_US:431855005|UMLS:C2316401	hp.json		http://purl.obolibrary.org/obo/HP_0012623		
HP:0000635	biolink:PhenotypicFeature	Blue irides	A markedly blue coloration of the iris.	SNOMEDCT_US:301952009|UMLS:C0578626	hp.json	Blue eyes	http://purl.obolibrary.org/obo/HP_0000635		
HP:0000634	biolink:PhenotypicFeature	Impaired ocular abduction	An impaired ability of the eye to move in the outward direction (towards the side of the head).	UMLS:C1846462	hp.json		http://purl.obolibrary.org/obo/HP_0000634		
HP:0000637	biolink:PhenotypicFeature	Long palpebral fissure	Distance between medial and lateral canthi is more than two standard deviations above the mean for age (objective); or, apparently increased length of the palpebral fissures.	UMLS:C1849340	hp.json	Wide palpebral fissure|Long opening between the eyelids|Wide palpebral fissures|Broad palpebral fissure|Wide opening between the eyelids|Broad opening between the eyelids|Long palpebral fissures	http://purl.obolibrary.org/obo/HP_0000637		hposlim_core
HP:0000636	biolink:PhenotypicFeature	Upper eyelid coloboma	A short discontinuity of the margin of the upper eyelid.	UMLS:C1863872	hp.json	Notched upper eyelid|Full thickness defect of the upper eyelid|Cleft upper eyelid|Coloboma of the upper eyelid|Upper eyelid colobomas	http://purl.obolibrary.org/obo/HP_0000636		
HP:0000639	biolink:PhenotypicFeature	Nystagmus	Rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms.	UMLS:C0028738|MSH:D009759|SNOMEDCT_US:563001	hp.json	Involuntary, rapid, rhythmic eye movements	http://purl.obolibrary.org/obo/HP_0000639		hposlim_core
UBERON:0007099	biolink:AnatomicalEntity	hyoid neural crest	Cranial neural crest that migrates into the hyoid arch.	ZFA:0007065|TAO:0007065|XAO:0000025	hp.json	hyoid crest	http://purl.obolibrary.org/obo/UBERON_0007099		
HP:0000631	biolink:PhenotypicFeature	Retinal arterial tortuosity	The presence of an increased number of twists and turns of the retinal artery.	SNOMEDCT_US:247123003|UMLS:C0423401	hp.json	Retinal artery tortuousity	http://purl.obolibrary.org/obo/HP_0000631		hposlim_core
UBERON:0007098	biolink:AnatomicalEntity	mandibular neural crest	Cranial neural crest that migrates into the mandibular arch.	ZFA:0007064|TAO:0007064|XAO:0000024	hp.json		http://purl.obolibrary.org/obo/UBERON_0007098		
HP:0000630	biolink:PhenotypicFeature	Abnormal retinal artery morphology		UMLS:C4021802	hp.json	Retinal arterial abnormality|Abnormality of retinal arteries	http://purl.obolibrary.org/obo/HP_0000630		
HP:0000633	biolink:PhenotypicFeature	Decreased lacrimation	Abnormally decreased lacrimation, that is, reduced ability to produce tears.	UMLS:C0235857	hp.json	Decreased tear secretion	http://purl.obolibrary.org/obo/HP_0000633		
HP:0000632	biolink:PhenotypicFeature	Lacrimation abnormality	Abnormality of tear production.	UMLS:C4021801	hp.json	Abnormality of tear production	http://purl.obolibrary.org/obo/HP_0000632		
HP:0012624	biolink:PhenotypicFeature	Stage 2 chronic kidney disease	A type of chronic kidney disease with mildly reduced glomerular filtration rate (GFR 60-89 mL/min/1.73 m2).	SNOMEDCT_US:431856006|UMLS:C2316786	hp.json		http://purl.obolibrary.org/obo/HP_0012624		
HP:0012625	biolink:PhenotypicFeature	Stage 3 chronic kidney disease	A type of chronic kidney disease with moderately reduced glomerular filtration rate (GFR 30-59 mL/min/1.73 m2).	SNOMEDCT_US:433144002|UMLS:C2316787	hp.json		http://purl.obolibrary.org/obo/HP_0012625		
HP:0012626	biolink:PhenotypicFeature	Stage 4 chronic kidney disease	A type of chronic kidney disease with severely reduced glomerular filtration rate (GFR 15-29 mL/min/1.73 m2).	UMLS:C2317473|SNOMEDCT_US:431857002	hp.json	Stage 4 chronic kidney disease	http://purl.obolibrary.org/obo/HP_0012626		
HP:0012627	biolink:PhenotypicFeature	Pseudoexfoliation	Deposition of fibrillar material that can be found on all anterior segment structures bathed by aqueous humor.	UMLS:C4022815	hp.json		http://purl.obolibrary.org/obo/HP_0012627		
HP:0012628	biolink:PhenotypicFeature	Abnormal suspensory ligament of lens morphology	An anomaly of the suspensory ligament of lens, also known as the ciliary zonule. These ligaments represent a series of fibers connecting the ciliary body and lens of the eye, holding the lens in place.	UMLS:C4021077	hp.json	Abnormality of the suspensory ligament of lens|Zonule of zinn abnormality|Abnormality of zinn's membrane|Ciliary zonule abnormality	http://purl.obolibrary.org/obo/HP_0012628		
HP:0012629	biolink:PhenotypicFeature	Phakodonesis	Tremulousness (trembling) of the lens of the eye.	UMLS:C2939415|SNOMEDCT_US:116669003	hp.json	Trembling eye lens|Phacodonesis	http://purl.obolibrary.org/obo/HP_0012629		
HP:0012610	biolink:PhenotypicFeature	Abnormality of urinary uric acid level	Abnormal amount of urate in the urine.	UMLS:C4022822	hp.json		http://purl.obolibrary.org/obo/HP_0012610		
HP:0012611	biolink:PhenotypicFeature	obsolete Increased urinary urate			hp.json		http://purl.obolibrary.org/obo/HP_0012611		
HP:0012612	biolink:PhenotypicFeature	Abnormal urinary sulfate concentration	Abnormal concentration of sulfate in the urine.	UMLS:C4022821	hp.json	Abnormal urinary sulphate concentration	http://purl.obolibrary.org/obo/HP_0012612		
HP:0000646	biolink:PhenotypicFeature	Amblyopia	Reduced visual acuity that is uncorrectable by lenses in the absence of detectable anatomic defects in the eye or visual pathways.	UMLS:C0002418|SNOMEDCT_US:387742006|MSH:D000550	hp.json	Wandering eye|Lazy eye|Wandering eyes	http://purl.obolibrary.org/obo/HP_0000646		hposlim_core
HP:0000648	biolink:PhenotypicFeature	Optic atrophy	Atrophy of the optic nerve. Optic atrophy results from the death of the retinal ganglion cell axons that comprise the optic nerve and manifesting as a pale optic nerve on fundoscopy.	SNOMEDCT_US:76976005|MSH:D009896|UMLS:C0029124	hp.json	Optic-nerve degeneration|Optic nerve atrophy	http://purl.obolibrary.org/obo/HP_0000648		hposlim_core
HP:0000647	biolink:PhenotypicFeature	Sclerocornea	A congenital anomaly in which a part or the whole of the cornea acquires the characteristics of sclera, resulting in clouding of the cornea.	MSH:C565209|UMLS:C1853235	hp.json	Hardening of skin and connective tissue	http://purl.obolibrary.org/obo/HP_0000647		hposlim_core
HP:0000649	biolink:PhenotypicFeature	Abnormality of visual evoked potentials	An anomaly of visually evoked potentials (VEP), which are electrical potentials, initiated by brief visual stimuli, which are recorded from the scalp overlying the visual cortex.	UMLS:C0522214|SNOMEDCT_US:102968003	hp.json	Abnormal visual-evoked potentials|Abnormal visual evoked potential|Abnormal vision evoked potentials|Abnormal visual evoked responses|VEP abnormalities	http://purl.obolibrary.org/obo/HP_0000649		hposlim_core
HP:0000640	biolink:PhenotypicFeature	Gaze-evoked nystagmus	Nystagmus made apparent by looking to the right or to the left.	UMLS:C0271390|MSH:D009760|SNOMEDCT_US:29356006	hp.json		http://purl.obolibrary.org/obo/HP_0000640		
HP:0000642	biolink:PhenotypicFeature	Red-green dyschromatopsia	Difficulty with discriminating red and green hues.	UMLS:C0155016|SNOMEDCT_US:246674000|UMLS:C1970168|SNOMEDCT_US:77479002|MSH:D003117	hp.json	Red green color blindness|Red/green color vision defect|Red/green colour vision defect|Dyschromatopsia with red-green confusion|Red green colour blindness	http://purl.obolibrary.org/obo/HP_0000642		
HP:0000641	biolink:PhenotypicFeature	Dysmetric saccades	The controller signal for saccadic eye movements has two components: the pulse that moves the eye rapidly from one point to the next, and the step that holds the eye in the new position. When both the pulse and the step are not the correct size, a dysmetric refixation eye movement results.	UMLS:C1836392	hp.json	Dysmetric eye saccades|Dysmetric eye movements|Uncoordinated eye movement	http://purl.obolibrary.org/obo/HP_0000641		hposlim_core
HP:0000643	biolink:PhenotypicFeature	Blepharospasm	A focal dystonia that affects the muscles of the eyelids and brow, associated with involuntary recurrent spasm of both eyelids.	MSH:D001764|UMLS:C0005747|SNOMEDCT_US:59026006	hp.json	Eyelid twitching|Eyelid spasm|Spontaneous closure of eyelid|Involuntary closure of eyelid	http://purl.obolibrary.org/obo/HP_0000643		
HP:0012613	biolink:PhenotypicFeature	Increased urinary sulfate	Elevated concentration of SO4(2-), i.e., sulfate, in the urine.	UMLS:C4022820	hp.json	Increased urinary sulphate	http://purl.obolibrary.org/obo/HP_0012613		
HP:0012614	biolink:PhenotypicFeature	Abnormal urine cytology	An anomalous finding in the examination of the urine for cells.	UMLS:C0587955|SNOMEDCT_US:310439007	hp.json		http://purl.obolibrary.org/obo/HP_0012614		
HP:0012615	biolink:PhenotypicFeature	Cylindruria	The presence of renal casts (cylindrical, cigar-shaped structures produced by the kidney in certain disease states) in the urine.	SNOMEDCT_US:5277004|UMLS:C0151990	hp.json	Urinary casts	http://purl.obolibrary.org/obo/HP_0012615		
HP:0012616	biolink:PhenotypicFeature	Leukocyte cylindruria	Presence of leukocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine.	UMLS:C4022819	hp.json	White blood cell casts	http://purl.obolibrary.org/obo/HP_0012616		
HP:0012617	biolink:PhenotypicFeature	Erythrocyte cylindruria	Presence of erythrocyte casts (cylindrical structures produced by the kidney in certain disease states) in the urine.	UMLS:C4022818	hp.json	Urinary erythrocyte cast|Red blood cell casts	http://purl.obolibrary.org/obo/HP_0012617		
HP:0012618	biolink:PhenotypicFeature	Urachal cyst	A cyst located along the allantois canal.	SNOMEDCT_US:17234001|MSH:D014496|UMLS:C0041915	hp.json		http://purl.obolibrary.org/obo/HP_0012618		
HP:0012619	biolink:PhenotypicFeature	Multiple bladder diverticula	Presence of a many diverticula (sac or pouch) in the wall of the urinary bladder.	UMLS:C4022817	hp.json	Multiple pouches in bladder wall	http://purl.obolibrary.org/obo/HP_0012619		
HP:0012600	biolink:PhenotypicFeature	Abnormal urine chloride concentration	An abnormal concentration of chloride in the urine.	UMLS:C4022827	hp.json	Abnormal urine Cl- concentration|Abnormal urine Cl concentration	http://purl.obolibrary.org/obo/HP_0012600		
HP:0012601	biolink:PhenotypicFeature	Hypochloriduria	An decreased concentration of chloride in the urine.	UMLS:C4021078	hp.json	Decreased urinary chloride|Low urine chloride levels	http://purl.obolibrary.org/obo/HP_0012601		
HP:0000613	biolink:PhenotypicFeature	Photophobia	Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.	UMLS:C4020887|UMLS:C0085636|MSH:D020795|SNOMEDCT_US:409668002|SNOMEDCT_US:246622003	hp.json	Extreme sensitivity of the eyes to light|Light hypersensitivity|Photodysphoria	http://purl.obolibrary.org/obo/HP_0000613		hposlim_core
HP:0000612	biolink:PhenotypicFeature	Iris coloboma	A coloboma of the iris.	UMLS:C0240063	hp.json	Keyhole iris|Cat eye|Coloboma of iris|Coloboma of the iris	http://purl.obolibrary.org/obo/HP_0000612		hposlim_core
HP:0000615	biolink:PhenotypicFeature	Abnormal pupil morphology	An abnormality of the pupil.	UMLS:C0154936|SNOMEDCT_US:274093008	hp.json	Abnormality of the pupil|Pupillary abnormality|Pupillary abnormalities|Abnormal pupillary morphology	http://purl.obolibrary.org/obo/HP_0000615		hposlim_core
HP:0000614	biolink:PhenotypicFeature	Abnormal nasolacrimal system morphology	An abnormality of the nasolacrimal drainage system, which serves as a conduit for tear flow from the external eye to the nasal cavity.	UMLS:C4025835	hp.json	Abnormality of the nasolacrimal system	http://purl.obolibrary.org/obo/HP_0000614		hposlim_core
HP:0000617	biolink:PhenotypicFeature	Abnormality of ocular smooth pursuit	An abnormality of eye movement characterized by impaired smooth-pursuit eye movements.	UMLS:C1836393	hp.json	Disrupted ocular pursuit movements|Impaired smooth pursuit ocular movements|Abnormal smooth pursuits|Irregular visual pursuit movements	http://purl.obolibrary.org/obo/HP_0000617		
HP:0000616	biolink:PhenotypicFeature	Miosis	Abnormal (non-physiological) constriction of the pupil.	MSH:D015877|UMLS:C0026205|SNOMEDCT_US:63251006	hp.json	Constricted pupils|Pupillary constriction	http://purl.obolibrary.org/obo/HP_0000616		hposlim_core
HP:0000619	biolink:PhenotypicFeature	Impaired convergence	Reduced ability to turn the eyes inward in order to focus on a nearby object.	MSH:D015835|UMLS:C0271379|SNOMEDCT_US:194131002	hp.json	Convergence insufficiency	http://purl.obolibrary.org/obo/HP_0000619		
HP:0000618	biolink:PhenotypicFeature	Blindness	Blindness is the condition of lacking visual perception defined as visual perception below 3/60 and/or a visual field of no greater than 10 degrees in radius around central fixation.	Fyler:4866|UMLS:C0456909|UMLS:C0271215|SNOMEDCT_US:65956007|MSH:D001766	hp.json	Legal blindness|Blindness|Total vision loss	http://purl.obolibrary.org/obo/HP_0000618		hposlim_core
CHEBI:15428	biolink:ChemicalSubstance	glycine	The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.	PMID:22079563|PMID:22434786|PMID:18840508|CAS:56-40-6|PMID:19120667|PMID:19916621|Drug_Central:1319|PMID:22293292|HMDB:HMDB0000123|PMID:11174716|PMID:12770151|PMID:18593588|PMID:16444815|PMID:22401276|PMID:11542461|DrugBank:DB00145|PMID:16151895|PMID:10930630|PMID:19738917|PMID:18396796|PMID:16918424|PMID:16105183|PMID:22234938|Gmelin:1808|PMID:17582620|PMID:18440992|PMID:16664855|PMID:21751272|PMID:18816054|PMID:19544666|PMID:16417482|PMID:15331688|PMID:18079355|PMID:11806864|MetaCyc:GLY|ECMDB:ECMDB00123|PMID:22044190|PMID:19449910|KEGG:C00037|PMID:22264337|PMID:15388434|PMID:12631515|CAS:56-40-6|PMID:17154252|PMID:16998855|PMID:16986325|PMID:11019925|KNApSAcK:C00001361|PDBeChem:GLY|Wikipedia:Glycine|PMID:15710237|PMID:19526731|Beilstein:635782|PMID:16214212|PMID:17970719|PMID:12754315|KEGG:D00011|PMID:16901953|PMID:17383967|Reaxys:635782|PMID:12921899|PMID:19924257|PMID:19028609|YMDB:YMDB00016|CAS:56-40-6	hp.json	Aminoessigsaeure|aminoacetic acid|glycine|Leimzucker|Glycocoll|H2N-CH2-COOH|aminoethanoic acid|Glycine|Hgly|Glykokoll|aminoethanoic acid|Aminoacetic acid|Glyzin|Gly|GLYCINE|Glycin|G	http://purl.obolibrary.org/obo/CHEBI_15428		3_STAR
HP:0000611	biolink:PhenotypicFeature	obsolete Choroid coloboma			hp.json		http://purl.obolibrary.org/obo/HP_0000611		
HP:0000610	biolink:PhenotypicFeature	Abnormal choroid morphology	Any structural abnormality of the choroid.	UMLS:C0008521|UMLS:C4025836|MSH:D015862	hp.json	Abnormality of the choroid|Choroid disease	http://purl.obolibrary.org/obo/HP_0000610		hposlim_core
HP:0012602	biolink:PhenotypicFeature	Renal chloride wasting	High urine chloride in the presence of hypochloridemia.	UMLS:C4022826	hp.json	Renal Cl wasting|Kidney chloride wasting|Renal Cl- wasting	http://purl.obolibrary.org/obo/HP_0012602		
HP:0012603	biolink:PhenotypicFeature	Abnormal urine sodium concentration	An abnormal concentration of sodium in the urine.	UMLS:C4022825	hp.json	Abnormal urine Na concentration|Abnormal urine Na+ levels	http://purl.obolibrary.org/obo/HP_0012603		
HP:0012604	biolink:PhenotypicFeature	Hyponatriuria	An abnormally decreased sodium concentration in the urine.	UMLS:C4022824	hp.json	Low urine sodium levels	http://purl.obolibrary.org/obo/HP_0012604		
HP:0012605	biolink:PhenotypicFeature	Hypernatriuria	An increased concentration of sodium(1+) in the urine.	UMLS:C3671887	hp.json	Increased urinary sodium	http://purl.obolibrary.org/obo/HP_0012605		
HP:0012606	biolink:PhenotypicFeature	Renal sodium wasting	An abnormally increased sodium concentration in the urine in the presence of hyponatremia.	UMLS:C2748576	hp.json	Kidney sodium wasting|Renal Na+ wasting|Renal Na wasting	http://purl.obolibrary.org/obo/HP_0012606		
HP:0012607	biolink:PhenotypicFeature	Abnormal urine magnesium concentration	An abnormal concentration of magnesium the urine.	UMLS:C4022823	hp.json	Abnormal urine magnesium concentration	http://purl.obolibrary.org/obo/HP_0012607		
HP:0012608	biolink:PhenotypicFeature	Hypermagnesiuria	An increased concentration of magnesium the urine.	UMLS:C2673443	hp.json		http://purl.obolibrary.org/obo/HP_0012608		
HP:0012609	biolink:PhenotypicFeature	Hypomagnesiuria	An decreased concentration of magnesium the urine.	UMLS:C3203528	hp.json	Low urine magnesium levels|Decreased urine magnesium	http://purl.obolibrary.org/obo/HP_0012609		
UBERON:0019042	biolink:AnatomicalEntity	reproductive system mucosa		BTO:0002439	hp.json	genital mucosa	http://purl.obolibrary.org/obo/UBERON_0019042		
HP:0000623	biolink:PhenotypicFeature	Supranuclear ophthalmoplegia	A vertical gaze palsy with inability to direct the gaze of the eyes downwards.	UMLS:C1408507	hp.json		http://purl.obolibrary.org/obo/HP_0000623		hposlim_core
HP:0000625	biolink:PhenotypicFeature	Eyelid coloboma	A short discontinuity of the margin of the lower or upper eyelid.	UMLS:C0521573|SNOMEDCT_US:95202004	hp.json	Full thickness defect of the eyelid|Notched eyelid|Cleft eyelid	http://purl.obolibrary.org/obo/HP_0000625		hposlim_core
HP:0000627	biolink:PhenotypicFeature	Posterior embryotoxon	A posterior embryotoxon is the presence of a prominent and anteriorly displaced line of Schwalbe.	SNOMEDCT_US:392437005|UMLS:C0546967|SNOMEDCT_US:253228006|UMLS:C0344531	hp.json	Embryotoxon	http://purl.obolibrary.org/obo/HP_0000627		hposlim_core
HP:0000629	biolink:PhenotypicFeature	Periorbital fullness	Increase in periorbital soft tissue.	UMLS:C1858036	hp.json	Periorbital swelling|Fullness around the eyes|Swelling around the eyes|Periorbital puffiness|Puffy eyes|Puffiness around eye	http://purl.obolibrary.org/obo/HP_0000629		
HP:0000620	biolink:PhenotypicFeature	Dacryocystitis	Inflammation of the nasolacrimal sac.	SNOMEDCT_US:85777005|UMLS:C0010930|MSH:D003607	hp.json	Infection of the lacrimal sac|Dacrocystitis	http://purl.obolibrary.org/obo/HP_0000620		
HP:0000622	biolink:PhenotypicFeature	Blurred vision	Lack of sharpness of vision resulting in the inability to see fine detail.	SNOMEDCT_US:246636008|SNOMEDCT_US:111516008|UMLS:C0344232	hp.json	Blurred vision	http://purl.obolibrary.org/obo/HP_0000622		hposlim_core
HP:0000621	biolink:PhenotypicFeature	Entropion	An abnormal inversion (turning inward) of the eyelid (usually the lower) towards the globe. Entropion is usually acquired as a result of involutional or cicatricial processes but may occasionally be congenital.	UMLS:C0014390|SNOMEDCT_US:33168009|MSH:D004774	hp.json	Inverted eyelid|Eyelid folded in|Eyelid turned in	http://purl.obolibrary.org/obo/HP_0000621		hposlim_core
HP:0012660	biolink:PhenotypicFeature	Thalamic hypometabolism in FDG PET	Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the thalamus as measured by positron emission tomography (PET) brain scan.	UMLS:C4022796	hp.json		http://purl.obolibrary.org/obo/HP_0012660		
HP:0012661	biolink:PhenotypicFeature	Hypothalamic hypometabolism in FDG PET	Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the hypothalamus as measured by positron emission tomography (PET) brain scan.	UMLS:C4022795	hp.json		http://purl.obolibrary.org/obo/HP_0012661		
HP:0012662	biolink:PhenotypicFeature	Parietal hypometabolism in FDG PET	Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the parietal cortex as measured by positron emission tomography (PET) brain scan.	UMLS:C4022794	hp.json		http://purl.obolibrary.org/obo/HP_0012662		
HP:0012663	biolink:PhenotypicFeature	Mildly reduced left ventricular ejection fraction	A small reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at least 50 percent, and a mild reduction is defined as 40-49 percent.	UMLS:C4022793	hp.json	Mildly reduced ejection fraction	http://purl.obolibrary.org/obo/HP_0012663		
HP:0012664	biolink:PhenotypicFeature	Reduced left ventricular ejection fraction	A diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle.	UMLS:C4022792	hp.json	Reduced ejection fraction	http://purl.obolibrary.org/obo/HP_0012664		
HP:0012665	biolink:PhenotypicFeature	Moderately reduced left ventricular ejection fraction	A medium reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle, defined as a left ventricular ejection fraction of 30-39 percent.	UMLS:C4022791	hp.json	Moderately reduced ejection fraction	http://purl.obolibrary.org/obo/HP_0012665		
HP:0012666	biolink:PhenotypicFeature	Severely reduced left ventricular ejection fraction	A large reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at over 50 percent, and a severe reduction is defined as less than 30 percent.	UMLS:C4022790	hp.json	Severely reduced ejection fraction	http://purl.obolibrary.org/obo/HP_0012666		
HP:0012667	biolink:PhenotypicFeature	Regional left ventricular wall motion abnormality	An abnormal motion of a segment of the left ventricle during the cardiac cycle.	UMLS:C4022789	hp.json		http://purl.obolibrary.org/obo/HP_0012667		
HP:0000679	biolink:PhenotypicFeature	Taurodontia	Increased volume of dental pulp of permanent molar characterized by a crown body-root ratio equal or larger than 1:1 or an elongated pulp chambers and apical displacement of the bifurcation or trifurcation of the roots.	UMLS:C4280616|UMLS:C0266039|SNOMEDCT_US:51744007|MSH:C536946	hp.json	Large elongated pulp chamber|Taurodontism|Taurodont	http://purl.obolibrary.org/obo/HP_0000679		hposlim_core
UBERON:0034670	biolink:AnatomicalEntity	palatal taste bud	A taste bud that is located on the soft palate, in the roof of the mouth.		hp.json	taste bud of palate	http://purl.obolibrary.org/obo/UBERON_0034670		
HP:0010005	biolink:PhenotypicFeature	Partial duplication of the middle phalanges of the hand	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the middle phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	UMLS:C4024115	hp.json	Partial duplication of the middle bones of hand	http://purl.obolibrary.org/obo/HP_0010005		
HP:0000678	biolink:PhenotypicFeature	Dental crowding	Changes in alignment of teeth in the dental arch	SNOMEDCT_US:12351004|MSH:D008310|UMLS:C1317785|UMLS:C0040433|UMLS:C4280618|UMLS:C4280617|SNOMEDCT_US:699222000	hp.json	Overcrowding of teeth|Dental overcrowding|Inadequate arch length for tooth size|Crowded teeth|Dental crowding|Tooth mass arch size discrepancy|Tooth size discrepancy	http://purl.obolibrary.org/obo/HP_0000678		hposlim_core
HP:0010004	biolink:PhenotypicFeature	Partial duplication of the distal phalanges of the hand	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the distal phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	UMLS:C4021348	hp.json	Partial duplication of the outermost bone of the hand|Bifid terminal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010004		
HP:0010003	biolink:PhenotypicFeature	Partial duplication of the proximal phalanges of the hand	A partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the proximal phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.	UMLS:C4024116	hp.json	Partial duplication of the innermost bones of the hand	http://purl.obolibrary.org/obo/HP_0010003		
HP:0010002	biolink:PhenotypicFeature	Complete duplication of the middle phalanges of the hand	A complete duplication affecting one or more of the middle phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accessory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a pseudoepiphysis (see corresponding terms) sometimes also referred to as hyperphalangism.	UMLS:C4024117	hp.json	Complete duplication of the middle bones of the hand	http://purl.obolibrary.org/obo/HP_0010002		
HP:0010001	biolink:PhenotypicFeature	Complete duplication of the distal phalanges of the hand	A complete duplication affecting one or more of the distal phalanges of the hand.	UMLS:C4024118	hp.json	Complete duplication of the outermost bones of the hand	http://purl.obolibrary.org/obo/HP_0010001		
HP:0010000	biolink:PhenotypicFeature	Complete duplication of the proximal phalanges of the hand	A complete duplication affecting one or more of the proximal phalanges of the hand. As opposed to a partial duplication were there is still a variable degree of fusion between the duplicated bones, a complete duplication leads to two separate bones appearing side to side (radio-ulnar axis) as seen on x-rays. A duplication leading to an accesory bone appearing in the proximo-distal axis on x-rays, this is actually a different entity called a Pseudoepiphyses (see according terms) sometimes also referred to as Hyperphalangism.	UMLS:C4024119	hp.json	Complete duplication of the innermost bones of the hand	http://purl.obolibrary.org/obo/HP_0010000		
HP:0000670	biolink:PhenotypicFeature	Carious teeth	Caries is a multifactorial bacterial infection affecting the structure of the tooth. This term has been used to describe the presence of more than expected dental caries.	UMLS:C4280623|SNOMEDCT_US:80967001|MSH:D003731|UMLS:C0011334	hp.json	Tooth decay|Dental cavities|Frequent caries|Cariosity of teeth|Early dental caries|Tooth cavities|Caries|Dental caries|Rotting teeth|Dental decay	http://purl.obolibrary.org/obo/HP_0000670		hposlim_core
HP:0000675	biolink:PhenotypicFeature	Macrodontia of permanent maxillary central incisor	Increased size of the maxillary central secondary incisor tooth.	UMLS:C1835095|UMLS:C4280621|UMLS:C4280620|UMLS:C4280263	hp.json	Large permanent maxillary central incisor|Hypertrophy of permanent maxillary central incisor|Increased width of permanent maxillary central incisor|Large permanent upper central incisor|Increased width of permanent upper central incisor|Increased size of permanent maxillary central incisor|Increased size of permanent upper central incisor|Long maxillary central incisors|Prominent, protruding upper incisors|Hyperplasia of permanent maxillary central incisor|Prominent upper incisors	http://purl.obolibrary.org/obo/HP_0000675		
HP:0010009	biolink:PhenotypicFeature	Abnormal 1st metacarpal morphology	A structural anomaly of the first metacarpal.	UMLS:C4024114	hp.json	Abnormality of the 1st long bone of hand|Abnormality of the 1st metacarpal	http://purl.obolibrary.org/obo/HP_0010009		
HP:0000674	biolink:PhenotypicFeature	Anodontia	The absence of all teeth from the normal series by a failure to develop.	SNOMEDCT_US:26624006|UMLS:C4280622|MSH:D000848|UMLS:C0399352|SNOMEDCT_US:16958000	hp.json	Complete agenesis of all teeth|Complete anodontia|Missing all teeth|Total absence of all teeth|Failure of development of all teeth|Total anodontia|Complete dental agenesis|Anodontia vera	http://purl.obolibrary.org/obo/HP_0000674		
HP:0010008	biolink:PhenotypicFeature	Duplication of the middle phalanx of hand	This term applies if one or more of the middle phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.	UMLS:C4021346	hp.json	Partial/complete duplication of the middle phalanges of the hand|Duplication of the middle bones of hand	http://purl.obolibrary.org/obo/HP_0010008		
HP:0000677	biolink:PhenotypicFeature	Oligodontia	The absence of six or more teeth from the normal series by a failure to develop.	UMLS:C4082304|UMLS:C4280619	hp.json	Failure of development of more than six teeth|Partial anodontia|Number of teeth decreased by more than six|Missing more than six teeth	http://purl.obolibrary.org/obo/HP_0000677		
HP:0010006	biolink:PhenotypicFeature	Duplication of the proximal phalanx of hand	This term applies if one or more of the proximal phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.	UMLS:C4021347	hp.json	Duplication of the innermost bones of hand|Partial/complete duplication of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0010006		
HP:0000676	biolink:PhenotypicFeature	Abnormality of the incisor	An abnormality of the Incisor tooth.	UMLS:C4025833	hp.json		http://purl.obolibrary.org/obo/HP_0000676		
HP:0012668	biolink:PhenotypicFeature	Vasovagal syncope		SNOMEDCT_US:398665005|UMLS:C0042420|SNOMEDCT_US:398652001|MSH:D019462|SNOMEDCT_US:234167006|UMLS:C0340854|MSH:D013575	hp.json	Reflex syncope|Neurocardiogenic syncope|Situational syncope	http://purl.obolibrary.org/obo/HP_0012668		
HP:0009005	biolink:PhenotypicFeature	Weakness of the intrinsic hand muscles		UMLS:C1834536	hp.json	Intrinsic hand muscle weakness	http://purl.obolibrary.org/obo/HP_0009005		
HP:0012669	biolink:PhenotypicFeature	Carotid sinus syncope	An exaggerated response to carotid sinus baroreceptor stimulation resulting in syncope from transient diminished cerebral perfusion.	UMLS:C0221046|SNOMEDCT_US:51723007|MSH:D013575	hp.json		http://purl.obolibrary.org/obo/HP_0012669		
HP:0009004	biolink:PhenotypicFeature	Hypoplasia of the musculature	Underdevelopment of the musculature.	UMLS:C0240414|SNOMEDCT_US:205530002	hp.json	Poorly developed skeletal musculature|Underdeveloped muscle|Underdeveloped muscles|Muscle hypoplasia	http://purl.obolibrary.org/obo/HP_0009004		
HP:0009007	biolink:PhenotypicFeature	Biceps hypoplasia	Underdevelopment of the biceps muscle.	UMLS:C1862499	hp.json	Underdeveloped biceps|Hypoplastic biceps	http://purl.obolibrary.org/obo/HP_0009007		
HP:0009003	biolink:PhenotypicFeature	Increased subcutaneous truncal adipose tissue	The presence of an abnormally increased amount of subcutaneous adipose tissue in the trunk of the body.	UMLS:C1837781	hp.json	Increased fat below the skin in trunk	http://purl.obolibrary.org/obo/HP_0009003		
HP:0009002	biolink:PhenotypicFeature	Loss of truncal subcutaneous adipose tissue	Loss (reduction of previously present) of subcutaneous adipose tissue in the region of the trunk.	UMLS:C1835384	hp.json	Loss of truncal adipose tissue|Loss of fat tissue in trunk|Loss of subcutaneous truncal adipose tissue	http://purl.obolibrary.org/obo/HP_0009002		
HP:0012650	biolink:PhenotypicFeature	Perisylvian polymicrogyria	Polymicrogyria (an excessive number of small gyri or convolutions) that is maximal in perisylvian regions (the regions that surround the Sylvian fissures), which may be symmetric or asymmetric and may extend beyond perisylvian regions. The Sylvian fissures often extend posteriorly and superiorly.	UMLS:C3279675	hp.json	Frontoparietal polymicrogyria	http://purl.obolibrary.org/obo/HP_0012650		
HP:0012651	biolink:PhenotypicFeature	Abasia	A severe form of gait ataxia such that an affected person cannot walk at all.	UMLS:C0877217	hp.json		http://purl.obolibrary.org/obo/HP_0012651		
HP:0009020	biolink:PhenotypicFeature	Exercise-induced muscle fatigue	An abnormally increased tendency towards muscle fatigue induced by physical exercise.	UMLS:C1855580	hp.json		http://purl.obolibrary.org/obo/HP_0009020		
HP:0012652	biolink:PhenotypicFeature	Exercise-induced asthma	Asthma attacks following exercise.	MSH:D001250|SNOMEDCT_US:31387002|UMLS:C0004099	hp.json	Exercise-induced asthma	http://purl.obolibrary.org/obo/HP_0012652		
HP:0012653	biolink:PhenotypicFeature	Status asthmaticus	Severe asthma unresponsive to repeated courses of beta-agonist therapy such as inhaled albuterol, levalbuterol, or subcutaneous epinephrine.	UMLS:C0038218|SNOMEDCT_US:708090002|MSH:D013224	hp.json	Acute severe asthma	http://purl.obolibrary.org/obo/HP_0012653		
HP:0012654	biolink:PhenotypicFeature	Abnormal CSF dopamine concentration	Abnormal concentration of dopamine in the cerebrospinal fluid (CSF).	UMLS:C4022802	hp.json	Abnormal CSF dopamine level	http://purl.obolibrary.org/obo/HP_0012654		
HP:0012655	biolink:PhenotypicFeature	Elevated CSF dopamine level	Increased concentration of dopamine in the cerebrospinal fluid (CSF).	UMLS:C4022801	hp.json		http://purl.obolibrary.org/obo/HP_0012655		
HP:0012656	biolink:PhenotypicFeature	Reduced CSF dopamine level	Decreased concentration of dopamine in the cerebrospinal fluid (CSF).	UMLS:C4022800	hp.json		http://purl.obolibrary.org/obo/HP_0012656		
UBERON:0034681	biolink:AnatomicalEntity	vocal organ	Any organ that is the primary organ of vocalization behavior. Examples: The laryngeal vocal cord (humans), the syrinx (birds).		hp.json		http://purl.obolibrary.org/obo/UBERON_0034681		
HP:0000689	biolink:PhenotypicFeature	Dental malocclusion	Dental malocclusion refers to an abnormality of the occlusion, or alignment, of the teeth and the way the upper and lower teeth fit together, resulting in overcrowding of teeth or in abnormal bite patterns.	UMLS:C4280614|UMLS:C4280613|SNOMEDCT_US:707598004|MSH:D008310|SNOMEDCT_US:47944004|UMLS:C0024636	hp.json	Bad bite|Bilateral crossbite malocclusion|Angle class 2 malocclusion|Angle class 3 malocclusion|Bilateral crossbite|Incorrect relation between upper and lower dental arches|Malocclusion|Malocclusion of teeth|Occlusion anomaly|Malalignment of upper and lower dental arches|Misalignment of upper and lower dental arches	http://purl.obolibrary.org/obo/HP_0000689		
HP:0000682	biolink:PhenotypicFeature	Abnormal dental enamel morphology	An abnormality of the dental enamel.	UMLS:C4021800|UMLS:C4280262|UMLS:C4280615	hp.json	Enamel abnormality|Enamel abnormalities|Malformation of dental enamel|Malformation of tooth enamel|Abnormal tooth enamel|Dystrophic tooth enamel|Abnormality of dental enamel|Defective tooth enamel	http://purl.obolibrary.org/obo/HP_0000682		hposlim_core
HP:0000684	biolink:PhenotypicFeature	Delayed eruption of teeth	Delayed tooth eruption, which can be defined as tooth eruption more than 2 SD beyond the mean eruption age.	SNOMEDCT_US:5639000|UMLS:C0239174	hp.json	Eruption, delayed|Delayed teeth eruption|Delayed tooth eruption|Late tooth eruption|Delayed eruption|Late eruption of teeth|Delayed dental eruption|Delayed dental development|Delayed eruption of teeth	http://purl.obolibrary.org/obo/HP_0000684		hposlim_core
HP:0000683	biolink:PhenotypicFeature	Grayish enamel	A grey discoloration of the dental enamel.	UMLS:C1854783	hp.json	Grey coloured tooth enamel|Grayish enamel|Gray colored tooth enamel|Grey tooth shade|Greyish enamel|Gray tooth shade	http://purl.obolibrary.org/obo/HP_0000683		
HP:0000685	biolink:PhenotypicFeature	Hypoplasia of teeth	Developmental hypoplasia of teeth.	UMLS:C0235357|UMLS:C4280611	hp.json	Underdevelopment of teeth|Hypoplastic teeth|Decreased size of teeth	http://purl.obolibrary.org/obo/HP_0000685		
HP:0009019	biolink:PhenotypicFeature	Progressive loss of facial adipose tissue		UMLS:C1837510	hp.json	Progressive loss of subcutaneous adipose tissue from face|Facial fat wasting|Atrophy of facial adipose tissue|Facial fat atrophy|Progressive loss of facial subcutaneous adipose tissue|Progressive loss of facial fat|Loss of subcutaneous adipose tissue from face, progressive	http://purl.obolibrary.org/obo/HP_0009019		
HP:0000687	biolink:PhenotypicFeature	Widely spaced teeth	Increased spaces (diastemata) between most of the teeth in the same dental arch.	UMLS:C1844813	hp.json	Generalised spacing of teeth|Multiple diastemata|Widely-spaced teeth|Wide-spaced teeth|Generalized dental spacing|Generalised dental spacing|Generalized spacing of teeth|Widely spaced teeth	http://purl.obolibrary.org/obo/HP_0000687		hposlim_core
HP:0009016	biolink:PhenotypicFeature	Upper limb muscle hypoplasia	Underdevelopment of muscles of the arm.	UMLS:C1846478	hp.json	Underdevelopment of upper limb muscles	http://purl.obolibrary.org/obo/HP_0009016		
HP:0012657	biolink:PhenotypicFeature	Abnormal brain positron emission tomography	A functional brain anomaly detectable by positron emission tomography (PET). PET scanning is a method for functional brain imaging, and its measurements reflect the amount of brain activity in the various regions of the brain.	UMLS:C4022799	hp.json	Abnormal brain PET scan	http://purl.obolibrary.org/obo/HP_0012657		
HP:0012658	biolink:PhenotypicFeature	Abnormal brain FDG positron emission tomography	An anomaly detectable in [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) brain scans. Glucose uptake measured with FDG-PET is a marker of neuronal metabolic activity.	UMLS:C4022798	hp.json	Abnormal brain FDG PET scan	http://purl.obolibrary.org/obo/HP_0012658		
HP:0012659	biolink:PhenotypicFeature	Prefrontal hypometabolism in FDG PET	Reduced uptake of [18F]-fluorodeoxyglucose (FDG) in the prefrontal cortex as measured by positron emission tomography (PET) brain scan.	UMLS:C4022797	hp.json		http://purl.obolibrary.org/obo/HP_0012659		
HP:0009017	biolink:PhenotypicFeature	Loss of gluteal subcutaneous adipose tissue	Loss (reduction of previously present) of subcutaneous adipose tissue in the gluteal region.	UMLS:C4024606	hp.json	Loss of fat tissue below the skin in gluts	http://purl.obolibrary.org/obo/HP_0009017		
HP:0009011	biolink:PhenotypicFeature	Hypoplasia of serratus anterior muscle	Underdevelopment of the serratus anterior muscle, which is involved in abduction, upward Rotation, and elevation of the scapula.	UMLS:C1868167	hp.json		http://purl.obolibrary.org/obo/HP_0009011		
HP:0000680	biolink:PhenotypicFeature	Delayed eruption of primary teeth	Delayed tooth eruption affecting the primary dentition.	UMLS:C1849538	hp.json	Delayed eruption of baby teeth|Late eruption of primary teeth|Late eruption of baby teeth|Delayed primary teeth eruption|Delayed eruption of milk teeth|Delayed eruption of deciduous teeth|Late eruption of milk teeth	http://purl.obolibrary.org/obo/HP_0000680		
HP:0009013	biolink:PhenotypicFeature	Congenital absence of gluteal muscles		UMLS:C2930932|MSH:C535561	hp.json		http://purl.obolibrary.org/obo/HP_0009013		
HP:0012640	biolink:PhenotypicFeature	Abnormality of intracranial pressure	A deviation from the norm of the intracranial pressure.	UMLS:C4022809	hp.json		http://purl.obolibrary.org/obo/HP_0012640		
HP:0012641	biolink:PhenotypicFeature	Decreased intracranial pressure	A reduction of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid.	SNOMEDCT_US:167714004|SNOMEDCT_US:277657001|UMLS:C0456892	hp.json	Intracranial hypotension	http://purl.obolibrary.org/obo/HP_0012641		
HP:0012642	biolink:PhenotypicFeature	Cerebellar agenesis	Cerebellar agenesis is defined by the near complete absence of cerebellar tissue with only remnants of the anterior vermis, flocculus, and/or middle cerebellar peduncles.	UMLS:C4022808	hp.json		http://purl.obolibrary.org/obo/HP_0012642		
HP:0012643	biolink:PhenotypicFeature	Foveal hypopigmentation	Decreased amount of pigmentation in the fovea centralis.	UMLS:C4022807	hp.json		http://purl.obolibrary.org/obo/HP_0012643		
HP:0012644	biolink:PhenotypicFeature	Increased caudate lactate level	An elevated concentration of lactate in the caudate nucleus. This finding can be elicited by magnetic resonance spectroscopy imaging.	UMLS:C4022806	hp.json		http://purl.obolibrary.org/obo/HP_0012644		
HP:0012645	biolink:PhenotypicFeature	Enlarged peripheral nerve	Increase in size of a peripheral nerve. This finding can be appreciated by palpation along the axis of the nerve.	UMLS:C2675074	hp.json	Enlarged peripheral nerves	http://purl.obolibrary.org/obo/HP_0012645		
HP:0000657	biolink:PhenotypicFeature	Oculomotor apraxia	Ocular motor apraxia is a deficiency in voluntary, horizontal, lateral, fast eye movements (saccades) with retention of slow pursuit movements. The inability to follow objects visually is often compensated by head movements. There may be decreased smooth pursuit, and cancellation of the vestibulo-ocular reflex.	UMLS:C3489733|SNOMEDCT_US:193662007|MSH:C537423|UMLS:C4020886	hp.json	Defective or absent horizontal voluntary eye movements|Ocular motor apraxia	http://purl.obolibrary.org/obo/HP_0000657		hposlim_core
HP:0000656	biolink:PhenotypicFeature	Ectropion	An outward turning (eversion) or rotation of the eyelid margin.	MSH:D004483|SNOMEDCT_US:62909004|UMLS:C0013592|SNOMEDCT_US:127559009	hp.json	Eyelid turned out|Eyelid folded out|Everted eyelid	http://purl.obolibrary.org/obo/HP_0000656		hposlim_core
HP:0000659	biolink:PhenotypicFeature	Peters anomaly	A form of anterior segment dysgenesis in which abnormal cleavage of the anterior chamber occurs. Peters anomaly is characterized by central, paracentral, or complete corneal opacity.	UMLS:C0344559|MSH:C537884|SNOMEDCT_US:204153003	hp.json		http://purl.obolibrary.org/obo/HP_0000659		hposlim_core
HP:0000658	biolink:PhenotypicFeature	Eyelid apraxia		SNOMEDCT_US:423142006|UMLS:C1142448	hp.json	Difficulty opening the eyelids	http://purl.obolibrary.org/obo/HP_0000658		
HP:0000651	biolink:PhenotypicFeature	Diplopia	Diplopia is a condition in which a single object is perceived as two images, it is also known as double vision.	SNOMEDCT_US:24982008|MSH:D004172|UMLS:C0012569	hp.json	Double vision	http://purl.obolibrary.org/obo/HP_0000651		hposlim_core
HP:0000650	biolink:PhenotypicFeature	Abnormal amplitude of pattern reversal visual evoked potentials		UMLS:C4025834	hp.json		http://purl.obolibrary.org/obo/HP_0000650		
HP:0000653	biolink:PhenotypicFeature	Sparse eyelashes	Decreased density/number of eyelashes.	UMLS:C1843300	hp.json	Sparse eyelashes|Partial absence of eyelashes|Hypotrichosis of eyelashes|Thin eyelashes|Scant eyelashes|Scanty eyelashes	http://purl.obolibrary.org/obo/HP_0000653		hposlim_core
HP:0000652	biolink:PhenotypicFeature	Lower eyelid coloboma	A short discontinuity of the margin of the lower eyelid.	UMLS:C1837826	hp.json	Coloboma of lower eyelid|Lower lid coloboma|Notched lower eyelid|Full thickness defect of the lower eyelid|Cleft lower eyelid	http://purl.obolibrary.org/obo/HP_0000652		
HP:0000655	biolink:PhenotypicFeature	obsolete Vitreoretinal degeneration			hp.json		http://purl.obolibrary.org/obo/HP_0000655		
HP:0000654	biolink:PhenotypicFeature	Decreased light- and dark-adapted electroretinogram amplitude	Descreased amplitude of eletrical response upon electroretinography.	UMLS:C1839025	hp.json	Reduced or abolished electroretinogram|Decreased electroretinogram response|Reduced electroretinogram|Reduced ERG|Decreased amplitudes on flash visual electroretinogram|Flattened or absent electroretinogram|Decreased electroretinogram amplitude|Decreased ERG amplitude|Decreased electroretinogram	http://purl.obolibrary.org/obo/HP_0000654		
HP:0012646	biolink:PhenotypicFeature	Retractile testis	A testis that is located at the upper scrotum or lower inguinal canal and that can be made to descend completely into the scrotum without resistance by manual reduction but returns to its original position by the cremasteric reflex.	UMLS:C0520578|SNOMEDCT_US:21779006	hp.json	Retractile testicle	http://purl.obolibrary.org/obo/HP_0012646		
HP:0012647	biolink:PhenotypicFeature	Abnormal inflammatory response	Any anomaly of the inflammatory response, a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.	UMLS:C4022805	hp.json	Abnormal inflammatory response	http://purl.obolibrary.org/obo/HP_0012647		
HP:0012648	biolink:PhenotypicFeature	Decreased inflammatory response	An abnormal reduction in the inflammatory response to injury or infection.	UMLS:C4022804	hp.json	Decreased inflammatory response	http://purl.obolibrary.org/obo/HP_0012648		
HP:0012649	biolink:PhenotypicFeature	Increased inflammatory response	A abnormal increase in the inflammatory response to injury or infection.	UMLS:C4022803	hp.json		http://purl.obolibrary.org/obo/HP_0012649		
HP:0012630	biolink:PhenotypicFeature	Abnormal trabecular meshwork morphology	An anomaly of the trabecular meshwork, which is the porelike structure surrounding the entire circumference of the anterior chamber at the base of the cornea and near the ciliary body. The trabecular mesh work is responsible for draining the aqueous humor into the canal of Schlemm.	UMLS:C4022814	hp.json	Abnormality of the trabecular meshwork	http://purl.obolibrary.org/obo/HP_0012630		
HP:0012631	biolink:PhenotypicFeature	Pigment deposition in the trabecular meshwork	Accumulation of abnormal amounts of pigment within the trabecular meshwork.	UMLS:C3805899	hp.json		http://purl.obolibrary.org/obo/HP_0012631		
HP:0012632	biolink:PhenotypicFeature	Abnormal intraocular pressure	An anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye.	UMLS:C0520999|MP:0005257|SNOMEDCT_US:24075007	hp.json	Abnormal intraocular pressure|Abnormal eye pressure	http://purl.obolibrary.org/obo/HP_0012632		
HP:0012633	biolink:PhenotypicFeature	Asymmetry of intraocular pressure	A difference in the amount of intraocular pressure in the right and left eye.	UMLS:C3805901	hp.json		http://purl.obolibrary.org/obo/HP_0012633		
HP:0012634	biolink:PhenotypicFeature	Iris pigment dispersion	Shedding of the pigment granules that normally adhere to the back of the iris into the aqueous humor.	UMLS:C4022813	hp.json		http://purl.obolibrary.org/obo/HP_0012634		
HP:0000668	biolink:PhenotypicFeature	Hypodontia	The absence of five or less teeth from the normal series by a failure to develop.	SNOMEDCT_US:64969001|MSH:D000848|UMLS:C0020608	hp.json	Missing between one and six teeth|Failure of development of between one and six teeth	http://purl.obolibrary.org/obo/HP_0000668		hposlim_core
HP:0000667	biolink:PhenotypicFeature	Phthisis bulbi	Atrophy of the eyeball with blindness and decreased intraocular pressure due to end-stage intraocular disease.	SNOMEDCT_US:4229009|UMLS:C0271007	hp.json		http://purl.obolibrary.org/obo/HP_0000667		hposlim_core
HP:0000660	biolink:PhenotypicFeature	Lipemia retinalis	A creamy appearance of the retinal blood vessels that occurs when the concentration of lipids in the blood are extremely increased, with pale pink to milky white retinal vessels and altered pale reflexes from choroidal vasculature.	SNOMEDCT_US:95692001|UMLS:C0339477	hp.json		http://purl.obolibrary.org/obo/HP_0000660		
HP:0000662	biolink:PhenotypicFeature	Nyctalopia	Inability to see well at night or in poor light.	MSH:D009755|UMLS:C4020885|UMLS:C0028077|SNOMEDCT_US:65194006	hp.json	Night-blindness|Night blindness|Poor night vision|Difficulties with night vision	http://purl.obolibrary.org/obo/HP_0000662		hposlim_core
HP:0000661	biolink:PhenotypicFeature	Palpebral fissure narrowing on adduction		UMLS:C1846465	hp.json		http://purl.obolibrary.org/obo/HP_0000661		
HP:0000664	biolink:PhenotypicFeature	Synophrys	Meeting of the medial eyebrows in the midline.	SNOMEDCT_US:253207002|UMLS:C0431447	hp.json	Synophris|Monobrow|Unibrow	http://purl.obolibrary.org/obo/HP_0000664		hposlim_core
HP:0000666	biolink:PhenotypicFeature	Horizontal nystagmus	Nystagmus consisting of horizontal to-and-fro eye movements.	UMLS:C0271385|SNOMEDCT_US:81756001|MSH:D009759	hp.json	Nystagmus, horizontal	http://purl.obolibrary.org/obo/HP_0000666		hposlim_core
HP:0012635	biolink:PhenotypicFeature	Iris hypoperfusion	Reduction in the amount of blood flow to the iris.	UMLS:C4022812	hp.json		http://purl.obolibrary.org/obo/HP_0012635		
HP:0012636	biolink:PhenotypicFeature	Retinal vein occlusion	Blockage of the retinal vein.	SNOMEDCT_US:46085004|UMLS:C0035328|MSH:D012170	hp.json		http://purl.obolibrary.org/obo/HP_0012636		
HP:0012637	biolink:PhenotypicFeature	Renal calcium wasting	High urine calcium in the presence of hypocalcemia.	UMLS:C2673441	hp.json	Kidney Ca wasting|Renal Ca2+ wasting|Kidney Ca2+ wasting|Renal Ca wasting|Kidney calcium wasting	http://purl.obolibrary.org/obo/HP_0012637		
HP:0012638	biolink:PhenotypicFeature	Abnormal nervous system physiology	A functional anomaly of the nervous system.	UMLS:C4022811	hp.json	Abnormality of nervous system physiology	http://purl.obolibrary.org/obo/HP_0012638		
HP:0012639	biolink:PhenotypicFeature	Abnormal nervous system morphology	A structural anomaly of the nervous system.	UMLS:C4022810|Fyler:4300|Fyler:4135	hp.json	Abnormality of nervous system morphology|Abnormal shape of nervous system	http://purl.obolibrary.org/obo/HP_0012639		
CL:0000525	biolink:Cell	syncytiotrophoblast cell	A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.	FMA:83043	hp.json	syntrophoblast|syncytial trophoblast|plasmidotrophoblast	http://purl.obolibrary.org/obo/CL_0000525		
CL:0000526	biolink:Cell	afferent neuron	A neuron which conveys sensory information centrally from the periphery.	FMA:87653	hp.json	input neuron	http://purl.obolibrary.org/obo/CL_0000526		
CHEBI:27470	biolink:ChemicalSubstance	folic acid	An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.	PMID:19335717|KNApSAcK:C00001539|CAS:59-30-3|PMID:19355913|PMID:24650098|PMID:17784727|PMID:34219855|PMID:10897644|AGR:IND606960789|PMID:8235383|PMID:15523939|DrugBank:DB00158|PMID:7738698|CAS:59-30-3|PMID:9420019|PMID:19121630|CAS:59-30-3|KEGG:C00504|PMID:15990733|HMDB:HMDB0000121|PMID:18788725|PMID:16380297|PMID:11451208|KEGG:D00070|PMID:16277678|PMID:14387833|FooDB:FDB014504|PMID:33965562|Beilstein:100781|PMID:33968971|PMID:33624660|PMID:15754725|PMID:9808641|MetaCyc:CPD-12826|Reaxys:100781|PMID:10138938|Wikipedia:Folic_Acid|PMID:9808640|PMID:11959400|PMID:15831910|PMID:9565830|PMID:16871332|Chemspider:5815|PMID:11261364|Drug_Central:1231|LINCS:LSM-5355|PMID:15321809|PMID:34207319|PMID:16093404|PMID:15797685|PDBeChem:FOL|PMID:9683174|PMID:9781393|PMID:15797531|PMID:9040515|PMID:10958818	hp.json	vitamin Be|Folate|Acfol|Folsaeure|pteroylmonoglutamic acid|vitamin Bc|vitamin M|Folicet|acidum folicum|PGA|N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid|(2S)-2-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzamido)pentanedioic acid|N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid|acide folique|pteroyl-L-glutamic acid|vitamin B9|pteroylglutamic acid|acido folico|folic acid|vitamin B11|pteroyl-L-monoglutamic acid|N-pteroyl-L-glutamic acid|PteGlu	http://purl.obolibrary.org/obo/CHEBI_27470		3_STAR
CL:0000527	biolink:Cell	efferent neuron	A neuron which sends impulses peripherally to activate muscles or secretory cells.		hp.json	output neuron	http://purl.obolibrary.org/obo/CL_0000527		
UBERON:0009678	biolink:AnatomicalEntity	tooth row	Anatomical cluster consisting of adjacent teeth constituting a row.	FMA:59415|ZFA:0001642|TAO:0001667	hp.json	tooth rows|row of teeth|dental arcade	http://purl.obolibrary.org/obo/UBERON_0009678		
UBERON:0009679	biolink:AnatomicalEntity	set of lower jaw teeth	A tooth row that is part of a skeleton of lower jaw.	EHDAA2:0001029|FMA:55635	hp.json	mandibular dental arcade|lower jaw teeth|arcus dentalis inferior|lower dental arcade|set of all lower teeth	http://purl.obolibrary.org/obo/UBERON_0009679		pheno_slim
UBERON:0007010	biolink:AnatomicalEntity	cleaving embryo	Organism at the cleavage stage.	BILA:0000058	hp.json		http://purl.obolibrary.org/obo/UBERON_0007010		
CL:0000521	biolink:Cell	fungal cell			hp.json		http://purl.obolibrary.org/obo/CL_0000521		
UBERON:0009670	biolink:AnatomicalEntity	rectal lumen	An anatomical space that surrounded_by a rectum.	FMA:14598|EMAPA:18388|SCTID:259740004|EHDAA2:0004587	hp.json	lumen of rectum	http://purl.obolibrary.org/obo/UBERON_0009670		
UBERON:0009676	biolink:AnatomicalEntity	early telencephalic vesicle		EFO:0003562|EHDAA:1993|EHDAA2:0001981|EMAPA:16914|EHDAA:2671	hp.json	early telencephalic vesicle|early telencephalic ventricle	http://purl.obolibrary.org/obo/UBERON_0009676		efo_slim
CHEBI:52424	biolink:ChemicalSubstance	EC 3.2.1.* (glycosidase) inhibitor	An EC 3.2.* (glycosylase) inhibitor that interferes with the action of any glycosidase (i.e. enzymes hydrolysing O- and S-glycosyl compounds, EC 3.2.1.*).		hp.json	EC 3.2.1.* inhibitors|glycosidase inhibitors|glycosidase (EC 3.2.1.*) inhibitor|glycosidase (EC 3.2.1.*) inhibitors|glycosidase inhibitor|EC 3.2.1.* inhibitor|glycoside hydrolase inhibitors|EC 3.2.1.* (glycosidase) inhibitors	http://purl.obolibrary.org/obo/CHEBI_52424		3_STAR
CHEBI:52425	biolink:ChemicalSubstance	EC 3.2.1.18 (exo-alpha-sialidase) inhibitor	An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein (EC 3.2.1.18), thus preventing the virus from budding from the host cell.		hp.json	neuraminidase inhibitors|acetylneuraminyl hydrolase inhibitors|exo-alpha-sialidase (EC 3.2.1.18) inhibitor|alpha-neuraminidase inhibitors|exo-alpha-sialidase inhibitors|EC 3.2.1.18 (exo-alpha-sialidase) inhibitors|sialidase inhibitors|sialidase inhibitor|exo-alpha-sialidase inhibitor|alpha-neuraminidase inhibitor|exo-alpha-sialidase (EC 3.2.1.18) inhibitors|neuraminidase inhibitor|acetylneuraminyl hydrolase inhibitor|EC 3.2.1.18 inhibitors|N-acylneuraminate glycohydrolase inhibitors|acetylneuraminidase inhibitors|acetylneuraminidase inhibitor|N-acylneuraminate glycohydrolase inhibitor|EC 3.2.1.18 inhibitor	http://purl.obolibrary.org/obo/CHEBI_52425		3_STAR
GO:1904206	biolink:BiologicalProcess	positive regulation of skeletal muscle hypertrophy	Any process that activates or increases the frequency, rate or extent of skeletal muscle hypertrophy.		hp.json	up regulation of skeletal muscle hypertrophy|activation of skeletal muscle hypertrophy|upregulation of skeletal muscle hypertrophy|up-regulation of skeletal muscle hypertrophy	http://purl.obolibrary.org/obo/GO_1904206		
GO:1904205	biolink:BiologicalProcess	negative regulation of skeletal muscle hypertrophy	Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle hypertrophy.		hp.json	down-regulation of skeletal muscle hypertrophy|down regulation of skeletal muscle hypertrophy|inhibition of skeletal muscle hypertrophy|downregulation of skeletal muscle hypertrophy	http://purl.obolibrary.org/obo/GO_1904205		
GO:1904204	biolink:BiologicalProcess	regulation of skeletal muscle hypertrophy	Any process that modulates the frequency, rate or extent of skeletal muscle hypertrophy.		hp.json		http://purl.obolibrary.org/obo/GO_1904204		
UBERON:0009668	biolink:AnatomicalEntity	ventral mesentery	Ventral mesentery is the part of the peritoneum closest to the navel.	EHDAA2:0004569	hp.json		http://purl.obolibrary.org/obo/UBERON_0009668		
UBERON:0009669	biolink:AnatomicalEntity	embryonic cloacal lumen	An anatomical space that surrounded_by a embryonic cloaca.	EHDAA2:0004586	hp.json		http://purl.obolibrary.org/obo/UBERON_0009669		
CL:0000530	biolink:Cell	primary neuron			hp.json		http://purl.obolibrary.org/obo/CL_0000530		
CL:0000531	biolink:Cell	primary sensory neuron			hp.json		http://purl.obolibrary.org/obo/CL_0000531		
UBERON:0009661	biolink:AnatomicalEntity	midbrain nucleus	Nucleus located in the midbrain.	TAO:0002209|ZFA:0001665|SCTID:279285003	hp.json		http://purl.obolibrary.org/obo/UBERON_0009661		
UBERON:0009662	biolink:AnatomicalEntity	hindbrain nucleus	Nucleus located within the hindbrain.	ZFA:0001658|TAO:0002177	hp.json		http://purl.obolibrary.org/obo/UBERON_0009662		
UBERON:0009663	biolink:AnatomicalEntity	telencephalic nucleus	A nucleus of brain that is part of a telencephalon.	ZFA:0001660|TAO:0002178	hp.json		http://purl.obolibrary.org/obo/UBERON_0009663		
UBERON:0009664	biolink:AnatomicalEntity	gut mesentery		MA:0003203|EMAPA:32911|EHDAA2:0004566	hp.json	peritoneal cavity mesentary|peritoneal mesentary	http://purl.obolibrary.org/obo/UBERON_0009664		
UBERON:0007005	biolink:AnatomicalEntity	cardiogenic splanchnic mesoderm	The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO].	EHDAA:385|FMA:293143|AAO:0011021|VHOG:0001641|SCTID:360387000|XAO:0000235|BILA:0000051|EHDAA2:0000214|EFO:0000315	hp.json	cardiogenic mesoderm|heart primordia|cardiac mesoderm|cardiogenic region|cardiogenic region|cardiogenic mesoderm|cardiogenic splanchnopleure	http://purl.obolibrary.org/obo/UBERON_0007005		pheno_slim|efo_slim
CL:0000509	biolink:Cell	gastrin secreting cell	A peptide hormone secreting cell that secretes gastrin.		hp.json		http://purl.obolibrary.org/obo/CL_0000509		
CL:0000502	biolink:Cell	type D enteroendocrine cell	A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin.	FMA:62935	hp.json	D cell	http://purl.obolibrary.org/obo/CL_0000502		
CL:0000506	biolink:Cell	enkephalin secreting cell	An endorphine cell that secretes enkephalin.		hp.json		http://purl.obolibrary.org/obo/CL_0000506		
CL:0000507	biolink:Cell	endorphin secreting cell	A peptide hormone secreting cell that secretes endorphin.		hp.json		http://purl.obolibrary.org/obo/CL_0000507		
CL:0000508	biolink:Cell	type G enteroendocrine cell	An endocrine cell found in the pyloric gland mucosa (antral mucosa) of the stomach of mammals and responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.	FMA:67609|BTO:0004108	hp.json	G cell	http://purl.obolibrary.org/obo/CL_0000508		
UBERON:0009657	biolink:AnatomicalEntity	artery of lip		NCIT:C52947|UMLS:C1708633|MA:0001987|EMAPA:37092	hp.json	labial artery	http://purl.obolibrary.org/obo/UBERON_0009657		
UBERON:0009651	biolink:AnatomicalEntity	nephron tubule basement membrane	A basement membrane that is part of a nephron tubule.	MA:0001680|UMLS:C1709901|NCIT:C49273|EMAPA:37490	hp.json	renal tubule basement membrane|renal tubular basement membrane|kidney tubule basement membrane	http://purl.obolibrary.org/obo/UBERON_0009651		
UBERON:0009652	biolink:AnatomicalEntity	bronchus basement membrane	A basement membrane that is part of a bronchus.	EMAPA:37809|MA:0001832|UMLS:C1707051|NCIT:C49208	hp.json	bronchial basement membrane	http://purl.obolibrary.org/obo/UBERON_0009652		
UBERON:0009653	biolink:AnatomicalEntity	trachea basement membrane	A basement membrane that is part of a trachea.	NCIT:C49302|EMAPA:37552|UMLS:C1710455|MA:0001854	hp.json		http://purl.obolibrary.org/obo/UBERON_0009653		
UBERON:0009654	biolink:AnatomicalEntity	alveolar artery	A branch of the maxillary artery that is found in the gingiva, premolars, and molars.	NCIT:C52848|EMAPA:37069|MA:0001913|UMLS:C1706783	hp.json		http://purl.obolibrary.org/obo/UBERON_0009654		human_reference_atlas
UBERON:0009655	biolink:AnatomicalEntity	auricular artery	An artery that supplies oxygenated blood to the ear.	MA:0001918|NCIT:C52849|EMAPA:37072|UMLS:C1706858	hp.json		http://purl.obolibrary.org/obo/UBERON_0009655		
CL:0000513	biolink:Cell	cardiac muscle myoblast	A precursor cell destined to differentiate into cardiac muscle cell.	FMA:84797	hp.json	cardiac muscle progenitor cell|cardiomyocyte progenitor cell	http://purl.obolibrary.org/obo/CL_0000513		
CL:0000514	biolink:Cell	smooth muscle myoblast	A precursor cell destined to differentiate into smooth muscle myocytes.	FMA:84798	hp.json	myoblast, smooth muscle|satellite cell	http://purl.obolibrary.org/obo/CL_0000514		
CL:0000515	biolink:Cell	skeletal muscle myoblast	A myoblast that differentiates into skeletal muscle fibers.	FMA:84799	hp.json	skeletal myoblast	http://purl.obolibrary.org/obo/CL_0000515		
NCBITaxon:40674	biolink:OrganismalEntity	Mammalia		GC_ID:1	hp.json	mammal-|mammals|mammal|mammals	http://purl.obolibrary.org/obo/NCBITaxon_40674		
UBERON:0009646	biolink:AnatomicalEntity	lumbar sympathetic nerve trunk	A sympathetic nerve trunk that is part of a lower back.	FMA:6263|NCIT:C52828|EMAPA:37655|MA:0001163|UMLS:C1708762	hp.json	lumbar sympathetic chain|lumbar sympathetic trunk|lumbar part of sympathetic trunk	http://purl.obolibrary.org/obo/UBERON_0009646		
CHEBI:39447	biolink:ChemicalSubstance	pyrimidines	Any compound having a pyrimidine as part of its structure.		hp.json		http://purl.obolibrary.org/obo/CHEBI_39447		3_STAR
UBERON:0009647	biolink:AnatomicalEntity	tympanic membrane epithelium	One of the two epithelia which make up the tympanic membrane (along with the fibrous layer).	EMAPA:19064|UMLS:C1711401|NCIT:C49308|MA:0001224	hp.json	tympanic membrane epithelial layer|tympanic epithelium	http://purl.obolibrary.org/obo/UBERON_0009647		
UBERON:0009648	biolink:AnatomicalEntity	eyelid subcutaneous connective tissue	An eyelid connective tissue that is part of a hypodermis.	FMA:63975|UMLS:C1707991|MA:0001252|NCIT:C49226|EMAPA:37533	hp.json	superficial fascia of eyelid	http://purl.obolibrary.org/obo/UBERON_0009648		
CL:0000511	biolink:Cell	androgen binding protein secreting cell	A peptide hormone secreting cell that secretes androgen binding protein.		hp.json		http://purl.obolibrary.org/obo/CL_0000511		
UBERON:0009640	biolink:AnatomicalEntity	hypophyseal cartilage	Forms around the developing pituitary, and together with prechordal cartilages creates body of sphenoid bone.		hp.json		http://purl.obolibrary.org/obo/UBERON_0009640		
UBERON:0009644	biolink:AnatomicalEntity	trachea non-cartilage connective tissue		EMAPA:35878|MA:0001859	hp.json		http://purl.obolibrary.org/obo/UBERON_0009644		
UBERON:0010698	biolink:AnatomicalEntity	manual digit metacarpus pre-cartilage condensation		VHOG:0000953|EMAPA:32850	hp.json	metacarpus pre-cartilage condensation|hand digit metacarpus pre-cartilage condensation|fore limb digit metacarpus pre-cartilage condensation|metacarpal pre-cartilage condensation|metacarpal bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010698		
UBERON:0010699	biolink:AnatomicalEntity	manual digit metacarpus cartilage element		EMAPA:32849	hp.json	finger metacarpus cartilage element|hand digit metacarpus cartilage element|metacarpus cartilage element|fore limb digit metacarpus cartilage element|metacarpal cartilage condensation|metacarpal cartilage element	http://purl.obolibrary.org/obo/UBERON_0010699		
CHEBI:39418	biolink:ChemicalSubstance	straight-chain saturated fatty acid	Any saturated fatty acid lacking a side-chain.	PMID:15644336	hp.json	straight-chain saturated fatty acid|straight-chain saturated fatty acids	http://purl.obolibrary.org/obo/CHEBI_39418		3_STAR
CHEBI:39417	biolink:ChemicalSubstance	branched-chain saturated fatty acid	Any saturated fatty acid with a carbon side-chain or isopropyl termination.		hp.json	branched-chain saturated fatty acids|branched saturated fatty acids|branched-chain saturated fatty acid|branched saturated fatty acid	http://purl.obolibrary.org/obo/CHEBI_39417		3_STAR
CHEBI:15440	biolink:ChemicalSubstance	squalene			hp.json		http://purl.obolibrary.org/obo/CHEBI_15440		
HP:0000609	biolink:PhenotypicFeature	Optic nerve hypoplasia	Underdevelopment of the optic nerve.	UMLS:C0338502|SNOMEDCT_US:95499004	hp.json	Hypoplastic optic nerves|Underdeveloped optic nerves	http://purl.obolibrary.org/obo/HP_0000609		
HP:0000602	biolink:PhenotypicFeature	Ophthalmoplegia	Paralysis of one or more extraocular muscles that are responsible for eye movements.	UMLS:C0029089|SNOMEDCT_US:16110005|MSH:D009886	hp.json	Paralysis of extraocular eye movement|Eye muscle paralysis	http://purl.obolibrary.org/obo/HP_0000602		
UBERON:0010693	biolink:AnatomicalEntity	pedal digit 1 epithelium	An epithelium that is part of a pedal digit 1.	EMAPA:17461|EHDAA2:0002038	hp.json	foot digit 1 epithelium|pedal digit I epithelium|hind limb digit 1 epithelium	http://purl.obolibrary.org/obo/UBERON_0010693		
HP:0000601	biolink:PhenotypicFeature	Hypotelorism	Interpupillary distance less than 2 SD below the mean (alternatively, the appearance of an decreased interpupillary distance or closely spaced eyes).	SNOMEDCT_US:44593008|UMLS:C0424711	hp.json	Decreased interpupillary distance|Decreased orbital separation|Decreased distance between eyes|Decreased distance between eye sockets|Closely spaced eyes|Abnormally close eyes|Ocular hypotelorism	http://purl.obolibrary.org/obo/HP_0000601		hposlim_core
UBERON:0010690	biolink:AnatomicalEntity	manual digit 1 epithelium	An epithelium that is part of a manual digit 1.	EHDAA2:0000512|EMAPA:17430	hp.json	manual digit I epithelium|hand digit 1 epithelium|fore limb digit 1 epithelium	http://purl.obolibrary.org/obo/UBERON_0010690		
HP:0000603	biolink:PhenotypicFeature	Central scotoma	An area of depressed vision located at the point of fixation and that interferes with central vision.	UMLS:C0152191|SNOMEDCT_US:38950008|UMLS:C4280624|MSH:D012607	hp.json	Central blind spot|Central scotomata|Blind spot located at fixation point	http://purl.obolibrary.org/obo/HP_0000603		hposlim_core
HP:0000606	biolink:PhenotypicFeature	Abnormality of the periorbital region	An abnormality of the region situated around the orbit of the eye.	UMLS:C4025837	hp.json	Abnormality of the region around the eye|Anomaly of the periorbital region|Abnormality of the region around the eye socket|Malformation of the periorbital region|Deformity of the periorbital region	http://purl.obolibrary.org/obo/HP_0000606		
UBERON:0010696	biolink:AnatomicalEntity	skeleton of pedal acropodium	The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the pedal autopodium - i.e. the bones of the foot or their cartilaginous precursors[cjm].	VSAO:0005030|FMA:78512	hp.json	set of phalanges of pes|pedal phalanges|hind acropodium skeleton|phalanges of foot|set of pedal phalanges|foot digit skeleton|posterior acropodium|posterior acropodium skeleton|all phalanges in hindlimb autopod|phalanges of pes|set of phalanges of foot	http://purl.obolibrary.org/obo/UBERON_0010696		
HP:0000605	biolink:PhenotypicFeature	Supranuclear gaze palsy	A supranuclear gaze palsy is an inability to look in a particular direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal.	UMLS:C1720037|SNOMEDCT_US:420675003	hp.json	Supranuclear gaze paralysis	http://purl.obolibrary.org/obo/HP_0000605		
UBERON:0010697	biolink:AnatomicalEntity	pedal digit metatarsal cartilage element		EMAPA:32951	hp.json	foot digit metatarsal cartilage condensation|hind limb digit metatarsal cartilage condensation|metatarsal cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010697		
HP:0000608	biolink:PhenotypicFeature	Macular degeneration	A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells of the macula lutea.	UMLS:C0024437|SNOMEDCT_US:422338006	hp.json	Pigmented macular degeneration	http://purl.obolibrary.org/obo/HP_0000608		
HP:0000607	biolink:PhenotypicFeature	Periorbital wrinkles		UMLS:C1844605	hp.json	Wrinkles around the eyes|Periorbital rhytids|Periorbital wrinkling|Excess periorbital skin wrinkling	http://purl.obolibrary.org/obo/HP_0000607		
UBERON:0010695	biolink:AnatomicalEntity	mesenchyme of tarsal region	Mesenchyme of the carpal region that contributes to the tarsal skeleton.	EMAPA:18502	hp.json		http://purl.obolibrary.org/obo/UBERON_0010695		
UBERON:0010687	biolink:AnatomicalEntity	pedal digit metatarsal pre-cartilage condensation		VHOG:0000948|EMAPA:32956|EMAPA:35568	hp.json	metatarsus pre-cartilage condensation|metatarsal pre-cartilage condensation|hind limb digit metatarsal pre-cartilage condensation|foot digit metatarsal pre-cartilage condensation|metatarsal bone pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010687		
GO:1904253	biolink:NamedThing	positive regulation of bile acid metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_1904253		
UBERON:0010688	biolink:AnatomicalEntity	skeleton of manual acropodium	The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the manual autopodium - i.e. the bones of the hands or their cartilaginous precursors[VSAO,modified].	FMA:71337|VSAO:0005029	hp.json	fore acropodium skeleton|manual digit skeleton|anterior acropodium skeleton|phalanges of manus|set of phalanges of hand|set of manual phalanges|all phalanges in forelimb autopod|set of phalanges of manus|phalanges of hand|anterior acropodium|hand digit skeleton|manual phalanges	http://purl.obolibrary.org/obo/UBERON_0010688		
GO:1904252	biolink:NamedThing	negative regulation of bile acid metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_1904252		
GO:1904251	biolink:NamedThing	regulation of bile acid metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_1904251		
HP:0000600	biolink:PhenotypicFeature	Abnormality of the pharynx	An anomaly of the pharynx, i.e., of the tubular structure extending from the base of the skull superiorly to the esophageal inlet inferiorly.	UMLS:C4025838	hp.json		http://purl.obolibrary.org/obo/HP_0000600		
UBERON:0010681	biolink:AnatomicalEntity	pedal digit 2 phalanx cartilage element	A cartilage element that is part of a pedal digit 2 mesenchyme.	EMAPA:18112	hp.json	foot digit 2 phalanx cartilage element|pedal digit II phalanx cartilage element|hind limb digit 2 phalanx cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010681		
UBERON:0010682	biolink:AnatomicalEntity	pedal digit 3 phalanx cartilage element	A cartilage element that is part of a pedal digit 3 mesenchyme.	EMAPA:18117	hp.json	foot digit 3 phalanx cartilage element|hind limb digit 3 phalanx cartilage condensation|pedal digit III phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0010682		
UBERON:0010680	biolink:AnatomicalEntity	pedal digit 1 phalanx cartilage element	A cartilage element that is part of a pedal digit 1 mesenchyme.	EMAPA:18107	hp.json	foot digit 1 phalanx cartilage element|hind limb digit 1 phalanx cartilage condensation|pedal digit I phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0010680		
UBERON:0010685	biolink:AnatomicalEntity	pedal digit phalanx cartilage element	A cartilage element that is part of a pedal digit mesenchyme.	EMAPA:32948	hp.json	foot digit phalanx cartilage element|hind limb digit phalanx cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010685		
UBERON:0010686	biolink:AnatomicalEntity	manual digit phalanx cartilage element	A cartilage element that is part of a manual digit mesenchyme.	EMAPA:32658	hp.json	hand digit phalanx cartilage condensation|fore limb digit phalanx cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010686		
UBERON:0010683	biolink:AnatomicalEntity	pedal digit 4 phalanx cartilage element	A cartilage element that is part of a pedal digit 4 mesenchyme.	EMAPA:18122	hp.json	foot digit 4 phalanx cartilage element|pedal digit IV phalanx cartilage element|hind limb digit 4 phalanx cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010683		
UBERON:0010684	biolink:AnatomicalEntity	pedal digit 5 phalanx cartilage element	A cartilage element that is part of a pedal digit 5 mesenchyme.	EMAPA:18127	hp.json	hind limb digit 5 phalanx cartilage condensation|pedal digit V phalanx cartilage element|foot digit 5 phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0010684		
GO:1904266	biolink:BiologicalProcess	regulation of Schwann cell chemotaxis	Any process that modulates the frequency, rate or extent of Schwann cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_1904266		
UBERON:0007037	biolink:AnatomicalEntity	mechanosensory system		BILA:0000142	hp.json		http://purl.obolibrary.org/obo/UBERON_0007037		
UBERON:0010678	biolink:AnatomicalEntity	manual digit 4 phalanx cartilage element	A cartilage element that is part of a manual digit 4 mesenchyme.	EMAPA:18081	hp.json	hand digit 4 phalanx cartilage element|manual digit IV phalanx cartilage element|fore limb digit 4 phalanx cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010678		
UBERON:0010679	biolink:AnatomicalEntity	manual digit 5 phalanx cartilage element	A cartilage element that is part of a manual digit 5 mesenchyme.	EMAPA:18086	hp.json	fore limb digit 5 phalanx cartilage condensation|hand digit 5 phalanx cartilage element|manual digit V phalanx cartilage element	http://purl.obolibrary.org/obo/UBERON_0010679		
UBERON:0010676	biolink:AnatomicalEntity	manual digit 2 phalanx cartilage element	A cartilage element that is part of a manual digit 2 mesenchyme.	EMAPA:18071	hp.json	hand digit 2 phalanx cartilage element|manual digit II phalanx cartilage element|fore limb digit 2 phalanx cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010676		
UBERON:0010677	biolink:AnatomicalEntity	manual digit 3 phalanx cartilage element	A cartilage element that is part of a manual digit 3 mesenchyme.	EMAPA:18076	hp.json	hand digit 3 phalanx cartilage element|manual digit III phalanx cartilage element|fore limb digit 3 phalanx cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010677		
UBERON:0009692	biolink:AnatomicalEntity	lumen of pharyngotympanic tube	An organ cavity that is part of a pharyngotympanic tube.	EHDAA2:0004118|FMA:60079	hp.json	lumen of auditory tube|auditory tube lumen|lumen of eustachian tube|pharyngotympanic tube lumen	http://purl.obolibrary.org/obo/UBERON_0009692		
UBERON:0009695	biolink:AnatomicalEntity	epithelium of laryngopharynx	An epithelium that is part of a hypopharynx.	FMA:62454|EHDAA2:0004575	hp.json	laryngopharynx epithelium|epithelium of laryngeal pharynx	http://purl.obolibrary.org/obo/UBERON_0009695		
UBERON:0009680	biolink:AnatomicalEntity	set of upper jaw teeth	A tooth row that is part of a skeleton of upper jaw.	EHDAA2:0002129|FMA:55634	hp.json	arcus dentalis superior|upper jaw teeth|set of all upper teeth|upper dental arcade|maxillary dental arcade	http://purl.obolibrary.org/obo/UBERON_0009680		pheno_slim
GO:1904269	biolink:CellularComponent	cell leading edge cell cortex	The cell cortex of the leading edge of a cell.		hp.json	peripheral cytoplasm of leading edge of cell|cell periphery of leading edge of cell|peripheral cytoplasm of cell leading edge|cell cortex of cell leading edge|cell periphery of cell leading edge|peripheral cytoplasm of front of cell|cell periphery of front of cell|cell cortex of front of cell|cell cortex of leading edge of cell	http://purl.obolibrary.org/obo/GO_1904269		
UBERON:0010675	biolink:AnatomicalEntity	manual digit 1 phalanx cartilage element	A cartilage element that is part of a manual digit 1 mesenchyme.	EMAPA:18066	hp.json	hand digit 1 phalanx cartilage element|manual digit I phalanx cartilage element|fore limb digit 1 phalanx cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010675		
GO:1904268	biolink:BiologicalProcess	positive regulation of Schwann cell chemotaxis	Any process that activates or increases the frequency, rate or extent of Schwann cell chemotaxis.		hp.json	up-regulation of Schwann cell chemotaxis|up regulation of Schwann cell chemotaxis|activation of Schwann cell chemotaxis|upregulation of Schwann cell chemotaxis	http://purl.obolibrary.org/obo/GO_1904268		
GO:1904267	biolink:BiologicalProcess	negative regulation of Schwann cell chemotaxis	Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell chemotaxis.		hp.json	inhibition of Schwann cell chemotaxis|downregulation of Schwann cell chemotaxis|down-regulation of Schwann cell chemotaxis|down regulation of Schwann cell chemotaxis	http://purl.obolibrary.org/obo/GO_1904267		
UBERON:0007026	biolink:AnatomicalEntity	presumptive gut		SCTID:360394002|UMLS:C1514442|BILA:0000084|NCIT:C34268	hp.json	primordial digestive tube|embryonic digestive tube|future digestive tube|primitive gut|future digestive tract|primordial gut|future gut	http://purl.obolibrary.org/obo/UBERON_0007026		
UBERON:0007023	biolink:AnatomicalEntity	adult organism	A multicellular organism that existence_ends_with a post-juvenile adult stage and existence_starts_with a post-juvenile adult stage.	BILA:0000078|FBbt:00003004|HAO:0000087|galen:Adult|TAO:0002046|NCIT:C17600|http://neurolex.org/wiki/Category:Adult_organism|UMLS:C0001675	hp.json	adults|adult	http://purl.obolibrary.org/obo/UBERON_0007023		
UBERON:0007021	biolink:AnatomicalEntity	sexually immature organism	A multicellular organism that is at the juvenile stage.	http://neurolex.org/wiki/Category:Juvenile_organism|BILA:0000076|TAO:0002047	hp.json	juvenile organism|juvenile|juveniles	http://purl.obolibrary.org/obo/UBERON_0007021		
NCBITaxon:5782	biolink:OrganismalEntity	Dictyostelium		GC_ID:1|PMID:29367151	hp.json	Hyalostilbum	http://purl.obolibrary.org/obo/NCBITaxon_5782		
GO:0003433	biolink:BiologicalProcess	chondrocyte development involved in endochondral bone morphogenesis	The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.		hp.json		http://purl.obolibrary.org/obo/GO_0003433		
UBERON:0009708	biolink:AnatomicalEntity	dorsal pancreas		EHDAA2:0001371	hp.json	pancreatis dorsalis	http://purl.obolibrary.org/obo/UBERON_0009708		human_reference_atlas|organ_slim
UBERON:0009709	biolink:AnatomicalEntity	ventral pancreas		EHDAA2:0001393	hp.json	pancreatis ventralis	http://purl.obolibrary.org/obo/UBERON_0009709		human_reference_atlas|organ_slim
UBERON:0009712	biolink:AnatomicalEntity	endocardium of right ventricle	Any endocardium that is part of the right ventricle of the heart.	VHOG:0001235|FMA:9536|EMAPA:17341|NCIT:C102343|EHDAA2:0002188|SCTID:8911002	hp.json	endocardial lining of right ventricle|right ventricle endocardial tissue|right ventricular endocardium|right ventricle endocardium	http://purl.obolibrary.org/obo/UBERON_0009712		
PR:000002112	biolink:Protein	vascular endothelial growth factor receptor 2	A vascular endothelial growth factor receptor that is a translation product of the human KDR gene or a 1:1 ortholog thereof.	IUPHARobj:1813	hp.json	KDR|protein-tyrosine kinase receptor flk-1|CD309|VEGFR-2|FLK-1|VEGFR2|kinase NYK|FLK1|kinase insert domain receptor|fetal liver kinase 1	http://purl.obolibrary.org/obo/PR_000002112		
UBERON:0009713	biolink:AnatomicalEntity	endocardium of left ventricle	Any endocardium that is part of the left ventricle of the heart.	EMAPA:17338|VHOG:0001233|FMA:9559|EHDAA2:0002182|SCTID:191004004	hp.json	left ventricle endocardium|left ventricular endocardium|endocardial lining of left ventricle|left ventricle endocardial tissue	http://purl.obolibrary.org/obo/UBERON_0009713		
UBERON:0009714	biolink:AnatomicalEntity	intermaxillary process	The primordial mass of tissue formed by the merging of the medial nasal prominences of the embryo; it contributes to the intermaxillary portion of the upper jaw, the prolabial portion of the upper lip, and the primary palate.	FMA:295872|EHDAA2:0000868|EHDAA:7856	hp.json	intermaxillary segment|globular process|globular processes of his	http://purl.obolibrary.org/obo/UBERON_0009714		
UBERON:0009715	biolink:AnatomicalEntity	stomodeal lumen	An anatomical cavity that surrounded_by a stomodeum.		hp.json	lumen of stomodeum|stomatodeal cavity|lumen of stomatodaeum	http://purl.obolibrary.org/obo/UBERON_0009715		
NCBITaxon:1963758	biolink:OrganismalEntity	Myomorpha		GC_ID:1	hp.json	Sciurognathi|mice and others	http://purl.obolibrary.org/obo/NCBITaxon_1963758		
CHEBI:52395	biolink:ChemicalSubstance	oxyketone	A compound with the general formula R2C=O (R=/=H) where one or more of the R groups contains an oxy (-O-) group.		hp.json	oxyketones	http://purl.obolibrary.org/obo/CHEBI_52395		3_STAR
CHEBI:52396	biolink:ChemicalSubstance	alpha-oxyketone	An oxyketone with the general formula R2C(=O) (R=/=H) where one or more of the R groups contains an oxy (-O-) group and the oxy and carbonyl groups are bonded to the same carbon atom.		hp.json	alpha-oxyketones	http://purl.obolibrary.org/obo/CHEBI_52396		3_STAR
CHEBI:64390	biolink:ChemicalSubstance	N-hexanoylglycine	An N-acylglycine in which the acyl group is specified as hexanoyl.	Patent:EP572167|Patent:EP517371|PMID:22770225|Patent:EP226304|HMDB:HMDB0000701|PMID:17190852|Patent:US5238917|Patent:EP580409|Reaxys:1773416|Patent:US4757066|Patent:EP415598|CAS:24003-67-6|Patent:US5112863|Patent:US5559092	hp.json	Hexanoylglycine|N-hexanoylglycine|N-(1-oxohexyl)glycine|Caproylglycine|N-caproylglycine|n-Hexanoylglycine	http://purl.obolibrary.org/obo/CHEBI_64390		3_STAR
PR:Q9WTK5	biolink:Protein	nuclear factor NF-kappa-B p100 subunit (mouse)	A nuclear factor NF-kappa-B p100 subunit that is encoded in the genome of mouse.	UniProtKB:Q9WTK5	hp.json	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (mouse)|mNFKB2|DNA-binding factor KBF2 (mouse)|Nfkb2	http://purl.obolibrary.org/obo/PR_Q9WTK5		
GO:0003414	biolink:BiologicalProcess	chondrocyte morphogenesis involved in endochondral bone morphogenesis	The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0003414		
GO:0003413	biolink:BiologicalProcess	chondrocyte differentiation involved in endochondral bone morphogenesis	The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.		hp.json		http://purl.obolibrary.org/obo/GO_0003413		
GO:0003416	biolink:BiologicalProcess	endochondral bone growth	The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.		hp.json		http://purl.obolibrary.org/obo/GO_0003416		
GO:0003411	biolink:BiologicalProcess	cell motility involved in camera-type eye morphogenesis	Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.		hp.json		http://purl.obolibrary.org/obo/GO_0003411		
CL:0000586	biolink:Cell	germ cell	The reproductive cell in multicellular organisms.	BTO:0000535|VHOG:0001534|WBbt:0006796	hp.json		http://purl.obolibrary.org/obo/CL_0000586		
CHEBI:146500	biolink:ChemicalSubstance	D-Galp-(1->3)-D-GalpNAc	An amino disaccharide that is 2-acetamido-2-deoxy-D-galactopyranose in which the hydroxy group at position 3 has been converted to the corresponding D-galactopyranoside. The stereochemistry at the anomeric position in each of the galactopyranose rings is not stated.	GlyTouCan:G01416HI|GlyGen:G01416HI|KEGG:G10100	hp.json	Gal(?1-3)GalNAc|N-[(3R,4R,5R,6R)-2,5-dihydroxy-6-(hydroxymethyl)-4-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide|D-galacto-hexopyranosyl-(1->3)-2-acetamido-2-deoxy-D-galacto-hexopyranose|WURCS=2.0/2,2,1/[a2112h-1x_1-5_2*NCC/3=O][a2112h-1x_1-5]/1-2/a3-b1|2-acetamido-2-deoxy-3-O-D-galactopyranosyl-D-galactopyranose	http://purl.obolibrary.org/obo/CHEBI_146500		3_STAR
CL:0000593	biolink:Cell	androgen secreting cell	A steroid hormone secreting cell that secretes androgen.		hp.json		http://purl.obolibrary.org/obo/CL_0000593		
CL:0000595	biolink:Cell	enucleate erythrocyte	An erythrocyte lacking a nucleus.		hp.json	red blood cell|RBC	http://purl.obolibrary.org/obo/CL_0000595		
CL:0000568	biolink:Cell	amine precursor uptake and decarboxylation cell	A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell.	FMA:83114|BTO:0003866	hp.json	APUD cell	http://purl.obolibrary.org/obo/CL_0000568		
CL:0000569	biolink:Cell	cardiac mesenchymal cell	A mesenchymal cell found in the developing heart and that develops into some part of the heart.  These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field.		hp.json		http://purl.obolibrary.org/obo/CL_0000569		
UBERON:0010740	biolink:AnatomicalEntity	bone of appendage girdle complex	A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle).	MA:0000688|EMAPA:35494	hp.json	bone of extended limb/fin region|limb bone|bone of extended limb/fin region	http://purl.obolibrary.org/obo/UBERON_0010740		pheno_slim
UBERON:0010741	biolink:AnatomicalEntity	bone of pectoral complex	A bone that is part of a pectoral complex. Examples: scapula, manus phalanx, any carpal bone, any bone of the pectoral fin.	EMAPA:35933|MA:0000612|EMAPA:32623	hp.json	forelimb bone|wing bone|bone of forelimb or pectoral fin or pectoral girdle	http://purl.obolibrary.org/obo/UBERON_0010741		pheno_slim
CL:0000561	biolink:Cell	amacrine cell	Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons.	BTO:0004044|FMA:67766	hp.json	amacrine neuron	http://purl.obolibrary.org/obo/CL_0000561		
CL:0000562	biolink:Cell	nucleate erythrocyte	An erythrocyte having a nucleus.		hp.json	red blood cell|RBC	http://purl.obolibrary.org/obo/CL_0000562		
UBERON:0009758	biolink:AnatomicalEntity	abdominal ganglion	A ganglion that is part of a abdominal segment of trunk.	SCTID:280508003	hp.json		http://purl.obolibrary.org/obo/UBERON_0009758		
UBERON:0010737	biolink:AnatomicalEntity	distal tarsal bone 4	Endochondral tarsal bone articulating with centralia and metatarsal 4.	VSAO:0005055|AAO:0000932	hp.json	tarsal 4|distal tarsal 4|os cuboideum|cuboideum|os tarsale IV	http://purl.obolibrary.org/obo/UBERON_0010737		
UBERON:0010738	biolink:AnatomicalEntity	distal tarsal bone 5	Endochondral tarsal bone articulating with centralia and metatarsal 5.	AAO:0000933|VSAO:0005056	hp.json	cuboideum|tarsal 5|distal tarsal 5	http://purl.obolibrary.org/obo/UBERON_0010738		
CL:0000566	biolink:Cell	angioblastic mesenchymal cell	A mesenchymal stem cell capable of developing into blood vessel endothelium.		hp.json	chondroplast|angioblast	http://purl.obolibrary.org/obo/CL_0000566		
UBERON:0009751	biolink:AnatomicalEntity	cardiac mesenchyme	The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures.	EMAPA:36438|EHDAA2:0004162	hp.json	heart mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009751		pheno_slim
UBERON:0009752	biolink:AnatomicalEntity	pancreas mesenchyme	The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas.	EMAPA:26220|EFO:0002557	hp.json		http://purl.obolibrary.org/obo/UBERON_0009752		pheno_slim|efo_slim|human_reference_atlas
GO:0003403	biolink:BiologicalProcess	optic vesicle formation	The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.		hp.json		http://purl.obolibrary.org/obo/GO_0003403		
GO:0003404	biolink:BiologicalProcess	optic vesicle morphogenesis	The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.		hp.json		http://purl.obolibrary.org/obo/GO_0003404		
CL:0000570	biolink:Cell	parafollicular cell	A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. Expresses a form of the neural cell adhesion molecule (N-CAM) on their surface. Secretes calcitonin, 5-hydroxytryptamine and dopamine.	FMA:68653	hp.json	C cell|parafollicular cell of thyroid gland|C cell of thyroid gland|thyroid parafollicular cell|clear cell of thyroid gland	http://purl.obolibrary.org/obo/CL_0000570		
UBERON:0009744	biolink:AnatomicalEntity	lymph node medullary sinus	The channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels.	EMAPA:37898|FMA:312359	hp.json	medullary sinus|lymph node medullary sinusoid	http://purl.obolibrary.org/obo/UBERON_0009744		pheno_slim|human_reference_atlas
UBERON:0009745	biolink:AnatomicalEntity	lymph node medullary cord	The dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node.	EMAPA:37897	hp.json	medullary cord	http://purl.obolibrary.org/obo/UBERON_0009745		pheno_slim|human_reference_atlas
UBERON:0010720	biolink:AnatomicalEntity	hindlimb zeugopod skeleton	Subdivision of skeleton consisting of all skeletal elements in an hindlimb zeugopod region. Typically consists of the tibia and the fibula.	VSAO:0005014|AAO:0000216	hp.json	skeleton cruris|crural skeleton|posterior zeugopodium|hindlimb zygopod skeleton|crus skeleton|hind epipodium|posterior zeugopodium skeleton|hindlimb epipodium|mesomere 2 of pelvic appendage	http://purl.obolibrary.org/obo/UBERON_0010720		
UBERON:0010721	biolink:AnatomicalEntity	distal tarsal bone	There are three cuneiform bones in the human foot: the medial cuneiform the intermediate cuneiform also known as the middle the lateral cuneiform. They are located between the navicular bone and the first, second and third metatarsal bones and are medial to the cuboid bone[WP, unvetted, human specific].	FMA:24517|AAO:0000914|NCIT:C32416|UMLS:C1511560	hp.json	distal tarsal bone|distal tarsal|cuneiform bone|os cuneiform|cuneiform|os cuneiforme	http://purl.obolibrary.org/obo/UBERON_0010721		
CL:0000573	biolink:Cell	retinal cone cell	One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.	FMA:67748|CALOHA:TS-0866|BTO:0001036	hp.json		http://purl.obolibrary.org/obo/CL_0000573		
CL:0000575	biolink:Cell	corneal epithelial cell	An epithelial cell of the cornea.	BTO:0004298|CALOHA:TS-0173|FMA:70551	hp.json	epithelial cell of cornea	http://purl.obolibrary.org/obo/CL_0000575		
UBERON:0009749	biolink:AnatomicalEntity	limb mesenchyme	The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells.	EMAPA:32705	hp.json	limb mesoderm	http://purl.obolibrary.org/obo/UBERON_0009749		pheno_slim
CL:0000576	biolink:Cell	monocyte	Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.	BTO:0000876|FMA:62864|CALOHA:TS-0638	hp.json		http://purl.obolibrary.org/obo/CL_0000576		
UBERON:0010728	biolink:AnatomicalEntity	sphenoid lesser wing pre-cartilage condensation	An orbitosphenoid endochondral element that is composed primarily of a pre-cartilage condensation.	EHDAA2:0003449	hp.json		http://purl.obolibrary.org/obo/UBERON_0010728		
GO:0003407	biolink:BiologicalProcess	neural retina development	The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.		hp.json		http://purl.obolibrary.org/obo/GO_0003407		
CL:0000547	biolink:Cell	proerythroblast	An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.	FMA:83518	hp.json	rubriblast|pronormoblast	http://purl.obolibrary.org/obo/CL_0000547		
CL:0000548	biolink:Cell	animal cell			hp.json		http://purl.obolibrary.org/obo/CL_0000548		_upper_level
CL:0000549	biolink:Cell	basophilic erythroblast	A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.	FMA:83505	hp.json	early erythroblast|basophilic normoblast|early normoblast|prorubricyte	http://purl.obolibrary.org/obo/CL_0000549		
UBERON:0010712	biolink:AnatomicalEntity	limb skeleton subdivision	Skeletal subdivision that is a segment of the limb skeleton.	VSAO:0005018	hp.json		http://purl.obolibrary.org/obo/UBERON_0010712		
CL:0000540	biolink:Cell	neuron	The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.	BTO:0000938|CALOHA:TS-0683|FBbt:00005106|VHOG:0001483|FMA:54527|WBbt:0003679	hp.json	nerve cell	http://purl.obolibrary.org/obo/CL_0000540		
CL:0000541	biolink:Cell	melanoblast	A cell that originates from the neural crest and differentiates into a pigment cell.	BTO:0003217|FMA:83377	hp.json		http://purl.obolibrary.org/obo/CL_0000541		
CL:0000542	biolink:Cell	lymphocyte	A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.	CALOHA:TS-0583|FMA:62863|BTO:0000775|VHOG:0001535	hp.json		http://purl.obolibrary.org/obo/CL_0000542		
UBERON:0010714	biolink:AnatomicalEntity	iliac cartilage element	An iliac endochondral element that is composed primarily of cartilage tissue.	EHDAA2:0000808|VHOG:0001126|EMAPA:18347	hp.json	iliac cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010714		
UBERON:0010719	biolink:AnatomicalEntity	girdle skeleton	The subdivision of the skeleton of either the pectoral or pelvic girdle.	AAO:0010686|VSAO:0000302	hp.json	skeleton of girdle	http://purl.obolibrary.org/obo/UBERON_0010719		
UBERON:0010718	biolink:AnatomicalEntity	pubic cartilage element	A pubic endochondral element that is composed primarily of cartilage tissue.	EMAPA:26928|EHDAA2:0001573	hp.json	pubic cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010718		
NCBITaxon:3193	biolink:OrganismalEntity	Embryophyta		GC_ID:1	hp.json	land plants|land plants|higher plants|plants	http://purl.obolibrary.org/obo/NCBITaxon_3193		
GO:1990188	biolink:MolecularActivity	euchromatin binding	Binding to euchromatin, a dispersed and relatively uncompacted form of chromatin.		hp.json		http://purl.obolibrary.org/obo/GO_1990188		
CL:0000556	biolink:Cell	megakaryocyte	A giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm.	CALOHA:TS-0611|FMA:83555|BTO:0000843	hp.json	megalokaryocyte|megacaryocyte|megalocaryocyte	http://purl.obolibrary.org/obo/CL_0000556		
GO:1990182	biolink:BiologicalProcess	exosomal secretion	The process whereby a membrane-bounded vesicle is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.		hp.json	extracellular vesicular exosome secretion|multi-vesicular body fusion with plasma membrane|exosomal secretory pathway|exosomal protein secretion|secretion of exosome	http://purl.obolibrary.org/obo/GO_1990182		
CL:0000557	biolink:Cell	granulocyte monocyte progenitor cell	A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.		hp.json	CFU-GM|granulocyte-macrophage progenitor|granulocyte/monocyte progenitor|GMP|granulocyte/monocyte precursor|colony forming unit granulocyte macrophage|CFU-C , Colony forming unit in culture	http://purl.obolibrary.org/obo/CL_0000557		
CL:0000558	biolink:Cell	reticulocyte	An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.	CALOHA:TS-0864|BTO:0001173	hp.json		http://purl.obolibrary.org/obo/CL_0000558		
CHEBI:27389	biolink:ChemicalSubstance	3-aminoisobutyric acid	A beta-amino-acid that is isobutyric acid in which one of the methyl hydrogens is substituted by an amino group.	Beilstein:1745458|PMID:22735334|PMID:639325|PMID:8307374|PMID:18600547|CAS:10569-72-9|PMID:19186330|MetaCyc:3-AMINO-ISOBUTYRATE|PMID:14576092|LIPID_MAPS_instance:LMFA01100054|PMID:2274753|Beilstein:1720958|Reaxys:1720958|CAS:10569-72-9|Gmelin:1520758|PMID:19735301|PMID:5776546|HMDB:HMDB0003911|Wikipedia:3-Aminoisobutyric_acid|PMID:18299183|CAS:144-90-1|CAS:144-90-1|KEGG:C05145|PMID:11785300	hp.json	3-aminoisobutyric acid|2-Methyl-beta-alanine|DL-beta-aminoisobutyric acid|alpha-Methyl-beta-alanine|beta-aminoisobutyric acid|3-Amino-2-methylpropanoate|2-(aminomethyl)propionic acid|3-amino-2-methylpropanoic acid|BAIB|bAib|3-Aminoisobutanoate|3-Aminoisobutanoic acid	http://purl.obolibrary.org/obo/CHEBI_27389		3_STAR
CL:0000559	biolink:Cell	promonocyte	A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.	FMA:83551|BTO:0004657	hp.json		http://purl.obolibrary.org/obo/CL_0000559		
UBERON:0009722	biolink:AnatomicalEntity	entire pharyngeal arch endoderm		EHDAA2:0004621|EMAPA:32754|FMA:293087	hp.json	pharyngeal arch endoderm	http://purl.obolibrary.org/obo/UBERON_0009722		
UBERON:0010700	biolink:AnatomicalEntity	phalanx pre-cartilage condensation		EMAPA:32720	hp.json		http://purl.obolibrary.org/obo/UBERON_0010700		
UBERON:0010701	biolink:AnatomicalEntity	phalanx cartilage element		EMAPA:32721	hp.json	phalanx cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010701		
CL:0000550	biolink:Cell	polychromatophilic erythroblast	A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.	FMA:83506	hp.json	polychromatophilic normoblast|intermediate erythroblast|polychromatic erythroblast|rubricyte|intermediate normoblast|polychromatic normoblast	http://purl.obolibrary.org/obo/CL_0000550		
CL:0000552	biolink:Cell	orthochromatic erythroblast	The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.	FMA:84646	hp.json	eosinophilic erythroblast|orthochromatic normoblast|acidophilic erythroblast|late erythoblast|pyknotic eto enrythroblast	http://purl.obolibrary.org/obo/CL_0000552		
CL:0000553	biolink:Cell	megakaryocyte progenitor cell	The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).	CALOHA:TS-0610|BTO:0001164|FMA:84235	hp.json	promegakaryocyte|CFU-Meg|megakaryocytic progenitor cell|colony-forming unit-megakaryocyte|MkP|megacaryocyte progenitor cell|megacaryoblast|promegacaryocyte|Meg-CFC|megakaryoblast	http://purl.obolibrary.org/obo/CL_0000553		
UBERON:0010702	biolink:AnatomicalEntity	digit mesenchyme	Mesenchyme of the digit region.	NCIT:C34141|EMAPA:32719	hp.json	digital ray	http://purl.obolibrary.org/obo/UBERON_0010702		
UBERON:0010703	biolink:AnatomicalEntity	forelimb zeugopod skeleton	The collection of all skeletal elements in an forelimb zeugopod region.	VSAO:0005011|AAO:0000200|FMA:71199	hp.json	antebrachial skeleton|forelimb epipodium skeleton|forelimb epipodium|anterior zeugopodium|wing zeugopod skeleton|fore epipodium|radius and ulna|antebrachium skeleton|mesomere 2 of pectoral appendage|skeleton of forearm|forearm skeleton|fore epipodium skeleton|anterior zeugopodium skeleton	http://purl.obolibrary.org/obo/UBERON_0010703		
CL:0000555	biolink:Cell	neuronal brush cell			hp.json		http://purl.obolibrary.org/obo/CL_0000555		
UBERON:0010708	biolink:AnatomicalEntity	pectoral complex	Appendage girdle complex that when present, encompasses the pectoral appendicular skeleton and the pectoral girdle.	EMAPA:37860|VSAO:0000213|FMA:7183	hp.json	upper limb and pectoral girdle|upper limb|pectoral appendage/girdle complex|upper limb and shoulder|pectoral girdle plus anterior limb or fin|pectoral girdle plus pectoral limb or fin	http://purl.obolibrary.org/obo/UBERON_0010708		pheno_slim
UBERON:0010709	biolink:AnatomicalEntity	pelvic complex	Appendage girdle complex that when present, encompasses the pelvic appendicular skeleton and the pelvic girdle.	SCTID:416631005|VSAO:0000215|EMAPA:37863|FMA:7184	hp.json	pelvic girdle plus posterior limb or fin|pelvic girdle plus pelvic limb or fin|lower limb and pelvic girdle|lower limb and pelvis|lower limb and pelvic girdle|pelvic girdle plus posterior limb or fin|pelvic appendage/girdle complex|pelvic girdle plus pelvic limb or fin|lower limb|lower limb and pelvis	http://purl.obolibrary.org/obo/UBERON_0010709		pheno_slim
UBERON:0010707	biolink:AnatomicalEntity	appendage girdle complex	An organism subdivision that includes both an appendage and its associated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc).	EMAPA:37858|VSAO:0000214|FMA:7182	hp.json	appendage/girdle complex|limb|girdle plus limb or fin|appendage complex|appendage-girdle complex|girdle plus limb or fin|appendage complex|appendage-girdle complex	http://purl.obolibrary.org/obo/UBERON_0010707		pheno_slim
HP:0012583	biolink:PhenotypicFeature	Unilateral renal hypoplasia	One sided hypoplasia of the kidney.	SNOMEDCT_US:204948009|UMLS:C0431691	hp.json	Small kidney on one side|Underdeveloped kidney on one side	http://purl.obolibrary.org/obo/HP_0012583		
HP:0012584	biolink:PhenotypicFeature	Bilateral renal hypoplasia	Two sided hypoplasia of the kidney.	SNOMEDCT_US:268232000|UMLS:C0431692	hp.json		http://purl.obolibrary.org/obo/HP_0012584		
HP:0012585	biolink:PhenotypicFeature	Renal atrophy	Atrophy of the kidney.	UMLS:C0341698|SNOMEDCT_US:197659005	hp.json	Kidney degeneration	http://purl.obolibrary.org/obo/HP_0012585		
HP:0012586	biolink:PhenotypicFeature	Bilateral renal atrophy	A two-sided form of atrophy of the kidney.	UMLS:C4022835	hp.json	Bilateral kidney degeneration	http://purl.obolibrary.org/obo/HP_0012586		
HP:0012587	biolink:PhenotypicFeature	Macroscopic hematuria	Hematuria that is visible upon inspection of the urine.	UMLS:C0473237|SNOMEDCT_US:197941005	hp.json	Bloody urine|Gross hematuria	http://purl.obolibrary.org/obo/HP_0012587		
HP:0012588	biolink:PhenotypicFeature	Steroid-resistant nephrotic syndrome	A form of nephrotic syndrome that does not respond to treatment with steroid medication, defined as persistent proteinuria despite 60mg/m2 or 2mg/kg for 8 weeks, after insuring no infection or non-adherence to medication.	SNOMEDCT_US:236381000|UMLS:C0403397	hp.json	SRNS	http://purl.obolibrary.org/obo/HP_0012588		
HP:0012589	biolink:PhenotypicFeature	Multidrug-resistant nephrotic syndrome	A form of nephrotic syndrome that does not respond to any immunosuppresive treatment.	UMLS:C4022834	hp.json		http://purl.obolibrary.org/obo/HP_0012589		
HP:0012580	biolink:PhenotypicFeature	Calcium phosphate nephrolithiasis	The presence of calcium- and phosphate-containing calculi (stones) in the kidneys.	UMLS:C3671880	hp.json	Ca phosphate urolithiasis|Ca2+ phosphate nephrolitiasis|Ca phosphate nephrolithiasis|Ca2+ phosphate urolithiasis|Calcium phosphate urolithiasis	http://purl.obolibrary.org/obo/HP_0012580		
HP:0012581	biolink:PhenotypicFeature	Simple renal cyst	An isolated cyst of the kidney.	UMLS:C0268800|UMLS:C4022836|SNOMEDCT_US:77945009	hp.json	single cortical cyst|Simple kidney cyst|Solitary renal cyst	http://purl.obolibrary.org/obo/HP_0012581		
HP:0012582	biolink:PhenotypicFeature	Bilateral renal dysplasia	A bilateral form of developmental dysplasia of the kidney.	SNOMEDCT_US:204950001|UMLS:C0431698	hp.json		http://purl.obolibrary.org/obo/HP_0012582		
HP:0000594	biolink:PhenotypicFeature	Shallow anterior chamber	Reduced depth of the anterior chamber, i.e., the anteroposterior distance between the cornea and the iris is decreased.	SNOMEDCT_US:246986004|UMLS:C0423276	hp.json		http://purl.obolibrary.org/obo/HP_0000594		
HP:0000593	biolink:PhenotypicFeature	Abnormal anterior chamber morphology	Abnormality of the anterior chamber, which is the space in the eye that is behind the cornea and in front of the iris.	SNOMEDCT_US:204142009|UMLS:C3152182	hp.json	Ocular anterior chamber abnormality|Anterior chamber anomalies|Abnormality of the anterior chamber	http://purl.obolibrary.org/obo/HP_0000593		hposlim_core
HP:0000598	biolink:PhenotypicFeature	Abnormality of the ear	An abnormality of the ear.	UMLS:C0266589|SNOMEDCT_US:275259005	hp.json	Abnormality of the ear|Ear anomaly	http://purl.obolibrary.org/obo/HP_0000598		hposlim_core
HP:0000597	biolink:PhenotypicFeature	Ophthalmoparesis	Ophthalmoplegia is a paralysis or weakness of one or more of the muscles that control eye movement.	UMLS:C0751401|MSH:D009886	hp.json	Extraocular muscle paralysis|Weakness of muscles controlling eye movement|Weakness of extraocular eye movement|Extraocular muscle palsy	http://purl.obolibrary.org/obo/HP_0000597		
HP:0000599	biolink:PhenotypicFeature	Abnormality of the frontal hairline	An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not.	UMLS:C4025839	hp.json	Abnormality of hairline at front of head|Abnormality of the frontal hairline	http://purl.obolibrary.org/obo/HP_0000599		
HP:0000590	biolink:PhenotypicFeature	Progressive external ophthalmoplegia	Initial bilateral ptosis followed by limitation of eye movements in all directions and slowing of saccades.	UMLS:C0162674|SNOMEDCT_US:46252003|MSH:D017246	hp.json	External ophthalmoplegia, progressive	http://purl.obolibrary.org/obo/HP_0000590		
HP:0000592	biolink:PhenotypicFeature	Blue sclerae	An abnormal bluish coloration of the sclera.	SNOMEDCT_US:204164000|UMLS:C0542514	hp.json	Blue outer white part of eyeball|Bluish sclerae|Blue sclera|Whites of eyes are a bluish-gray colour|Whites of eyes are a bluish-gray color	http://purl.obolibrary.org/obo/HP_0000592		hposlim_core
HP:0000591	biolink:PhenotypicFeature	Abnormal sclera morphology	An abnormality of the sclera.	UMLS:C4025840	hp.json	Abnormality of the outer white part of eyeball|Abnormality of the sclera	http://purl.obolibrary.org/obo/HP_0000591		hposlim_core
HP:0012572	biolink:PhenotypicFeature	Ureter duplex	A complete duplication of the ureter, where the duplicated ureters have separate insertions into the bladder.	SNOMEDCT_US:49496001|UMLS:C0221365|ICD-10:Q62.5	hp.json		http://purl.obolibrary.org/obo/HP_0012572		
HP:0012573	biolink:PhenotypicFeature	Global proximal tubulopathy	A type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption with bicarbonate loss and resulting acidosis.	UMLS:C4022839	hp.json		http://purl.obolibrary.org/obo/HP_0012573		
HP:0012574	biolink:PhenotypicFeature	Mesangial hypercellularity	Increased numbers of mesangial cells per glomerulus, defined as more than 3 nuclei fully surrounded by matrix in one or more mesangial areas, not including perihilar region, on a standard 3-micron-thick tissue section, best evaluated on periodic acid-Schiff (PAS) stain.	SNOMEDCT_US:125510009|UMLS:C0545017	hp.json	Mesangial proliferation	http://purl.obolibrary.org/obo/HP_0012574		
HP:0012575	biolink:PhenotypicFeature	Abnormal nephron morphology	A structural anomaly of the nephron.	UMLS:C4022838	hp.json	Abnormality of the nephron	http://purl.obolibrary.org/obo/HP_0012575		
HP:0012576	biolink:PhenotypicFeature	Glomerular C3 deposition	The presence of complement 3 deposits in the glomerulus.	UMLS:C4022837	hp.json	C3 nephropathy|Renal C3 deposition	http://purl.obolibrary.org/obo/HP_0012576		
HP:0012577	biolink:PhenotypicFeature	Thin glomerular basement membrane	Decreased thickness of the glomerular basement membrane (GBM), measured from endothelial to visceral epithelial plasma membrane and mainly attributable to a decrease in thickness of the lamina densa, generally to an overall thickness more than 2 standard deviations less than that of the normal mean GBM thickness for health age- and sex matched individuals. May be focal or diffuse, although the term thin GBMs generally implies thinning of over 50% of GBMs.	UMLS:C3276821	hp.json		http://purl.obolibrary.org/obo/HP_0012577		
HP:0012578	biolink:PhenotypicFeature	Membranous nephropathy	A type of glomerulonephropathy characterized by thickening of the basement membrane and deposition of immune complexes in the subepithelial space.	SNOMEDCT_US:77182004|MSH:D015433|UMLS:C0017665	hp.json	Membranous glomerulonephritis	http://purl.obolibrary.org/obo/HP_0012578		
HP:0012579	biolink:PhenotypicFeature	Minimal change glomerulonephritis	The presence of minimal changes visible by light microscopy but flattened and fused podocyte foot processes on electron microscopy in a person with nephrotic range proteinuria.	UMLS:C0027721|MSH:D009402|SNOMEDCT_US:44785005	hp.json	Minimal change nephropathy|Minimal change disease	http://purl.obolibrary.org/obo/HP_0012579		
HP:0012570	biolink:PhenotypicFeature	Synovial sarcoma	A type of mesenchymal tissue cell tumor that exhibits epithelial differentiation, which most frequently arises in the extremities.	SNOMEDCT_US:302851001|MSH:D013584|SNOMEDCT_US:63211008|UMLS:C0039101	hp.json	Malignant synovioma	http://purl.obolibrary.org/obo/HP_0012570		
HP:0012571	biolink:PhenotypicFeature	Ureter fissus	A partial duplication of the ureter where the duplicated ureters fuse to a single ureter before their insertion into the bladder.	UMLS:C4021079|ICD-10:Q62.5	hp.json	Partially duplicated ureter	http://purl.obolibrary.org/obo/HP_0012571		
CHEBI:78954	biolink:ChemicalSubstance	(omega-1)-hydroxy fatty acid	A hydroxy fatty acid that is a straight-chain fatty acid in which one of the hydrogens attached to the carbon adjacent to the terminal methyl group (i.e. at the (omega-1) position) is replaced by a hydroxy group.		hp.json	(omega-1)-hydroxy fatty acids	http://purl.obolibrary.org/obo/CHEBI_78954		3_STAR
HP:0012561	biolink:PhenotypicFeature	Unicuspid aortic valve	The presence of an aortic valve with one instead of the normal three cusps (flaps).	SNOMEDCT_US:253610004|UMLS:C0345001	hp.json		http://purl.obolibrary.org/obo/HP_0012561		
HP:0012562	biolink:PhenotypicFeature	Premature epimetaphyseal fusion in hand	Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the hand, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.	UMLS:C4022844	hp.json		http://purl.obolibrary.org/obo/HP_0012562		
HP:0012563	biolink:PhenotypicFeature	Premature epimetaphyseal fusion in foot	Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the foot, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.	UMLS:C4022843	hp.json		http://purl.obolibrary.org/obo/HP_0012563		
HP:0012564	biolink:PhenotypicFeature	Premature epimetaphyseal fusion in tibia	Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the tibia, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.	UMLS:C4022842	hp.json		http://purl.obolibrary.org/obo/HP_0012564		
HP:0012565	biolink:PhenotypicFeature	Premature epimetaphyseal fusion in fibula	Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the fibula, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.	UMLS:C4021838	hp.json		http://purl.obolibrary.org/obo/HP_0012565		
HP:0012566	biolink:PhenotypicFeature	Premature epimetaphyseal fusion in radius	Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the radius, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.	UMLS:C4022841	hp.json		http://purl.obolibrary.org/obo/HP_0012566		
HP:0012567	biolink:PhenotypicFeature	Premature epimetaphyseal fusion in ulna	Stop of growth at the epiphyseal plate the hyaline cartilage plate in the metaphysis at one or more long bones in the ulna, at an earlier than normal age, resulting in growth arrest and shortening of the involved bone.	UMLS:C4022840	hp.json		http://purl.obolibrary.org/obo/HP_0012567		
HP:0012568	biolink:PhenotypicFeature	Lower eyelid edema	Edema in the region of the Lower eyelid.	UMLS:C3839997|UMLS:C2025810|SNOMEDCT_US:700327003	hp.json	Swelling of lower eyelid|Lower eyelid oedema|Cellulitis of lower eyelid|Puffiness of lower eyelid|Fullness of lower eyelid	http://purl.obolibrary.org/obo/HP_0012568		
HP:0000579	biolink:PhenotypicFeature	Nasolacrimal duct obstruction	Blockage of the lacrimal duct.	SNOMEDCT_US:246865000|UMLS:C0022906|UMLS:C1281931|MSH:D007767|SNOMEDCT_US:416920000|SNOMEDCT_US:314022009|SNOMEDCT_US:231841004	hp.json	Blocked tear duct|Lacrimal duct obstruction	http://purl.obolibrary.org/obo/HP_0000579		hposlim_core
HP:0012560	biolink:PhenotypicFeature	Decreased T3/T4 ratio	A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is lower than normal.	UMLS:C4022845	hp.json		http://purl.obolibrary.org/obo/HP_0012560		
HP:0000572	biolink:PhenotypicFeature	Visual loss	Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise the term reduced visual acuity should be used (or a subclass of that).	SNOMEDCT_US:7973008|UMLS:C3665386	hp.json	Vision loss|Loss of vision|Visual loss	http://purl.obolibrary.org/obo/HP_0000572		
HP:0000571	biolink:PhenotypicFeature	Hypometric saccades	Saccadic undershoot, i.e., a saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object.	UMLS:C0423082|SNOMEDCT_US:246768008	hp.json		http://purl.obolibrary.org/obo/HP_0000571		
HP:0000574	biolink:PhenotypicFeature	Thick eyebrow	Increased density/number and/or increased diameter of eyebrow hairs.	UMLS:C1853487	hp.json	Hypertrichosis of the eyebrows|Bushy eyebrows|Thick eyebrows|Hypertrichosis of the eyebrow|Dense eyebrow|Thick eyebrow|Prominent eyebrows|Heavy eyebrows	http://purl.obolibrary.org/obo/HP_0000574		hposlim_core
HP:0000573	biolink:PhenotypicFeature	Retinal hemorrhage	Hemorrhage occurring within the retina.	UMLS:C0035317|MSH:D012166|SNOMEDCT_US:28998008	hp.json	Retinal haemorrhage|Retinal bleeding|Retinal haemorrhages|Retinal hemorrhages	http://purl.obolibrary.org/obo/HP_0000573		hposlim_core
HP:0000576	biolink:PhenotypicFeature	Centrocecal scotoma	A scotoma (area of diminished vision within the visual field) located between the central point of fixation and the blind spot with a roughly horizontal oval shape.	SNOMEDCT_US:33014001|UMLS:C0271196|MSH:D012607	hp.json		http://purl.obolibrary.org/obo/HP_0000576		
HP:0000575	biolink:PhenotypicFeature	Scotoma	A regional and pathological increase of the light detection threshold in any region of the visual field surrounded by a field of normal or relatively well-preserved vision.	SNOMEDCT_US:81016008|MSH:D009898|SNOMEDCT_US:23388006|UMLS:C0036454|MSH:D012607|UMLS:C0344233	hp.json	Blind spot	http://purl.obolibrary.org/obo/HP_0000575		hposlim_core
HP:0000577	biolink:PhenotypicFeature	Exotropia	A form of strabismus with one or both eyes deviated outward.	MSH:D005099|UMLS:C0015310|SNOMEDCT_US:399054005|SNOMEDCT_US:399252000	hp.json	Outward facing eye ball	http://purl.obolibrary.org/obo/HP_0000577		hposlim_core
HP:0012569	biolink:PhenotypicFeature	Delayed menarche	First period after the age of 15 years.	UMLS:C0949173	hp.json	Delayed start of first period	http://purl.obolibrary.org/obo/HP_0012569		
HP:0000570	biolink:PhenotypicFeature	Abnormal saccadic eye movements	An abnormality of eye movement characterized by impairment of fast (saccadic) eye movements.	UMLS:C1842584|UMLS:C4025841	hp.json	Abnormality of saccadic eye movements|Impaired saccades	http://purl.obolibrary.org/obo/HP_0000570		
HP:0012550	biolink:PhenotypicFeature	Colonic varices	The presence of varices (enlarged and convoluted blood vessels) in the colon.	UMLS:C4022853	hp.json		http://purl.obolibrary.org/obo/HP_0012550		
HP:0012551	biolink:PhenotypicFeature	Absent neutrophil specific granules	Lack of specific granules in neutrophils.	UMLS:C4022852	hp.json		http://purl.obolibrary.org/obo/HP_0012551		
HP:0012552	biolink:PhenotypicFeature	Increased neutrophil nuclear projections	Presence of an elevated number of projections from nuclei of neutrophils. These projections can have the shape of hooks, tags, or clubs.	UMLS:C4022851	hp.json		http://purl.obolibrary.org/obo/HP_0012552		
HP:0012553	biolink:PhenotypicFeature	Hypoplastic thumbnail	A thumbnail that is diminished in length and width, i.e., underdeveloped thumb nail.	UMLS:C4022850	hp.json	Small thumbnail|Underdeveloped thumbnail	http://purl.obolibrary.org/obo/HP_0012553		
HP:0012554	biolink:PhenotypicFeature	Absent thumbnail	Absence of thumb nail.	UMLS:C4022849	hp.json		http://purl.obolibrary.org/obo/HP_0012554		
HP:0012555	biolink:PhenotypicFeature	Absent nail of hallux	Absent nail of big toe.	UMLS:C4021081	hp.json	Absent big toe nail|Absent nail of big toe	http://purl.obolibrary.org/obo/HP_0012555		
HP:0012556	biolink:PhenotypicFeature	Hyperbeta-alaninemia	Increased concentration of beta-alanine in the blood.	UMLS:C4021080	hp.json	Hyperbetaalaninemia|High blood beta-alanine levels	http://purl.obolibrary.org/obo/HP_0012556		
HP:0012557	biolink:PhenotypicFeature	EEG with centrotemporal focal spike waves	EEG with focal sharp transient waves in the centrotemporal region of the brain (also known as the central sulcus), i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.	UMLS:C4022848	hp.json		http://purl.obolibrary.org/obo/HP_0012557		
HP:0000582	biolink:PhenotypicFeature	Upslanted palpebral fissure	The palpebral fissure inclination is more than two standard deviations above the mean for age (objective); or, the inclination of the palpebral fissure is greater than typical for age.	SNOMEDCT_US:246799009|UMLS:C0423109	hp.json	Upslanting palpebral fissures|Mongoloid slant|Upward slanting of the opening between the eyelids|Upward slanted palpebral fissures|Upslanted palpebral fissures|Upward slanting of palpebral fissures|Upward slanting palpebral fissures	http://purl.obolibrary.org/obo/HP_0000582		hposlim_core
HP:0000585	biolink:PhenotypicFeature	Band keratopathy	An abnormality of the cornea characterized by the deposition of calcium in a band across the central cornea, leading to decreased vision, foreign body sensation, and ocular irritation.	MSH:C562399|SNOMEDCT_US:35055000|UMLS:C0155120	hp.json	Calcific band keratopathy	http://purl.obolibrary.org/obo/HP_0000585		hposlim_core
HP:0000584	biolink:PhenotypicFeature	Punctate corneal epithelial erosions		UMLS:C1832170	hp.json		http://purl.obolibrary.org/obo/HP_0000584		
HP:0000587	biolink:PhenotypicFeature	Abnormality of the optic nerve	Abnormality of the optic nerve.	UMLS:C0029131	hp.json	Optic nerve issue|optic nerve abnormalities	http://purl.obolibrary.org/obo/HP_0000587		hposlim_core
CHEBI:66998	biolink:ChemicalSubstance	histidinate derivative	A carboxylic acid anion which is a conjugate base of  a histidine derivative  having either D- or L-configuration.		hp.json	histidinate derivatives	http://purl.obolibrary.org/obo/CHEBI_66998		3_STAR
HP:0000586	biolink:PhenotypicFeature	Shallow orbits	Reduced depth of the orbits associated with prominent-appearing ocular globes.	UMLS:C1865244	hp.json	Decreased depth of orbits|Shallow eye sockets|Small shallow orbits|Decreased depth of eye sockets	http://purl.obolibrary.org/obo/HP_0000586		
HP:0000589	biolink:PhenotypicFeature	Coloboma	A developmental defect characterized by a cleft of some portion of the eye or ocular adnexa.	Fyler:4311|SNOMEDCT_US:92828000|UMLS:C0009363|MSH:D003103|SNOMEDCT_US:93390002	hp.json	Ocular coloboma|Ocular colobomas|Notched pupil	http://purl.obolibrary.org/obo/HP_0000589		
HP:0000588	biolink:PhenotypicFeature	Optic disc coloboma	A cleft of the optic nerve that extends inferiorly.	MSH:C535970|SNOMEDCT_US:17541006|SNOMEDCT_US:44295002|UMLS:C0155299	hp.json	Optic disk coloboma|Coloboma of optic nerve|Optic nerve coloboma	http://purl.obolibrary.org/obo/HP_0000588		hposlim_core
HP:0012558	biolink:PhenotypicFeature	Abnormal T3/T4 ratio	A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that deviates from normal.	UMLS:C4022847	hp.json		http://purl.obolibrary.org/obo/HP_0012558		
HP:0012559	biolink:PhenotypicFeature	Increased T3/T4 ratio	A ratio of serum triiodothyronine (T3) to thyroxine (T4) in the blood that is higher than normal.	UMLS:C4022846	hp.json		http://purl.obolibrary.org/obo/HP_0012559		
HP:0000581	biolink:PhenotypicFeature	Blepharophimosis	A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures.	MSH:D016569|UMLS:C0005744	hp.json	Narrow opening between the eyelids|Decreased width of palpebral fissure	http://purl.obolibrary.org/obo/HP_0000581		hposlim_core
HP:0000580	biolink:PhenotypicFeature	Pigmentary retinopathy	An abnormality of the retina characterized by pigment deposition. It is typically associated with migration and proliferation of macrophages or retinal pigment epithelial cells into the retina; melanin from these cells causes the pigmentary changes. Pigmentary retinopathy is a common final pathway of many retinal conditions and is often associated with visual loss.	SNOMEDCT_US:28835009|UMLS:C0035334|MSH:D012174	hp.json	Retinal pigmentary degeneration|Retinal pigmentary clumping|Pigmentary retinal deposits|Retinal pigment clumping	http://purl.obolibrary.org/obo/HP_0000580		
CHEBI:64365	biolink:ChemicalSubstance	aralkylamino compound	An organic amino compound in which an aminoalkyl group is linked to an arene.		hp.json	aralkylamino compounds	http://purl.obolibrary.org/obo/CHEBI_64365		3_STAR
HP:0012594	biolink:PhenotypicFeature	Moderate albuminuria	The presence of moderately increased concentrations of albumin in the urine, defined as and albumin-creatinine ratio (ACR) of 30 to 299 mg/gm (3.4 to 34 mg/mmol).	SNOMEDCT_US:312975006|UMLS:C1654921|UMLS:C0730345	hp.json	High urine albumin levels|Microalbuminuria	http://purl.obolibrary.org/obo/HP_0012594		
HP:0012595	biolink:PhenotypicFeature	Mild proteinuria	Mildly increased levels of protein in the urine (150-500 mg per day in adults).	UMLS:C4022832	hp.json		http://purl.obolibrary.org/obo/HP_0012595		
HP:0012596	biolink:PhenotypicFeature	Moderate proteinuria	Moderately increased levels of protein in the urine (500-1000 mg per day in adults).	UMLS:C4022831	hp.json		http://purl.obolibrary.org/obo/HP_0012596		
HP:0012597	biolink:PhenotypicFeature	Heavy proteinuria	Severely increased levels of protein in the urine (1000-3000 mg per day in adults).	UMLS:C4022830	hp.json	Severly high blood protein levels	http://purl.obolibrary.org/obo/HP_0012597		
HP:0012598	biolink:PhenotypicFeature	Abnormal urine potassium concentration	An abnormal concentration of potassium(1+) in the urine.	UMLS:C4022829	hp.json	Abnormal urine K concentration	http://purl.obolibrary.org/obo/HP_0012598		
HP:0012599	biolink:PhenotypicFeature	Abnormal urine phosphate concentration	An abnormal phosphate concentration in the urine.	UMLS:C4022828	hp.json		http://purl.obolibrary.org/obo/HP_0012599		
HP:0012590	biolink:PhenotypicFeature	Abnormal urine output	An abnormal amount of urine production.	UMLS:C3693260	hp.json		http://purl.obolibrary.org/obo/HP_0012590		
HP:0012591	biolink:PhenotypicFeature	Abnormal urinary electrolyte concentration	An abnormality in the concentration of electrolytes in the urine.	UMLS:C4022833	hp.json	Urinary electrolyte imbalance	http://purl.obolibrary.org/obo/HP_0012591		
HP:0012592	biolink:PhenotypicFeature	Albuminuria	Increased concentration of albumin in the urine.	MSH:D000419|SNOMEDCT_US:274769005|UMLS:C0001925	hp.json		http://purl.obolibrary.org/obo/HP_0012592		
HP:0012593	biolink:PhenotypicFeature	Nephrotic range proteinuria	Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children.	UMLS:C0445118|SNOMEDCT_US:264867001	hp.json		http://purl.obolibrary.org/obo/HP_0012593		
HP:0012740	biolink:PhenotypicFeature	Papilloma	A tumor of the skin or mucous membrane with finger-like projections.	MSH:D010212|UMLS:C0030354|SNOMEDCT_US:23730008|SNOMEDCT_US:711329002	hp.json		http://purl.obolibrary.org/obo/HP_0012740		
CHEBI:30921	biolink:ChemicalSubstance	glutarate(2-)	A dicarboxylic acid dianion obtained by deprotonation of both the carboxy groups of glutaric acid.	Reaxys:3904695|Beilstein:3904695|Gmelin:240388	hp.json	glutarate|pentanedioate	http://purl.obolibrary.org/obo/CHEBI_30921		3_STAR
HP:0012741	biolink:PhenotypicFeature	Unilateral cryptorchidism	Absence of a testis from the scrotum on one side owing to failure of the testis or testes to descend through the inguinal canal to the scrotum.	MSH:D003456|UMLS:C0431664|SNOMEDCT_US:268227001	hp.json	Cryptorchidism, unilateral	http://purl.obolibrary.org/obo/HP_0012741		
UBERON:0019198	biolink:AnatomicalEntity	dorsal nerve of clitoris	The deep terminal division of the pudendal nerve that runs along the dorsum of the clitoral shaft and innervates the the glans clitoris.	FMA:21870	hp.json	dorsal nerve of the clitoris|nervus dorsalis clitoridis	http://purl.obolibrary.org/obo/UBERON_0019198		
HP:0012742	biolink:PhenotypicFeature	Thin fingernail	Fingernail that appears thin when viewed on end.	UMLS:C4022750	hp.json	Thin fingernail	http://purl.obolibrary.org/obo/HP_0012742		
CHEBI:30920	biolink:ChemicalSubstance	3-hydroxy-3-methylglutarate(1-)	A dicarboxylic acid monoanion resulting from the removal of a proton from one of the carboxylic acid groups of 3-hydroxy-3-methylglutaric acid.		hp.json	4-carboxy-3-hydroxy-3-methylbutanoate	http://purl.obolibrary.org/obo/CHEBI_30920		3_STAR
HP:0012743	biolink:PhenotypicFeature	Abdominal obesity	Excessive fat around the stomach and abdomen.	MSH:D056128|SNOMEDCT_US:248311001|UMLS:C0311277	hp.json	Central obesity|Abdominal obesity	http://purl.obolibrary.org/obo/HP_0012743		
UBERON:0019196	biolink:AnatomicalEntity	iliac artery endothelium		BTO:0004661	hp.json		http://purl.obolibrary.org/obo/UBERON_0019196		
HP:0012744	biolink:PhenotypicFeature	Femoral aplasia	Failure of the femur to develop.	SNOMEDCT_US:47276000|UMLS:C0265629	hp.json	Absent femur|Aplasia of the femur|Absent thighbone	http://purl.obolibrary.org/obo/HP_0012744		
UBERON:0019197	biolink:AnatomicalEntity	dorsal nerve of penis	The deep terminal division of the pudendal nerve that runs along the dorsum of the penis and innervates the the corpus cavernosum penis, the prepuce and the glans penis.	FMA:21869	hp.json	nervus dorsalis penis <male>|nervus dorsalis penis|dorsal nerve of penis|dorsal nerves of the penis	http://purl.obolibrary.org/obo/UBERON_0019197		
HP:0000756	biolink:PhenotypicFeature	Agoraphobia	A type of anxiety disorder characterized by avoidance of public places, especially where crowds gather.	SNOMEDCT_US:70691001|MSH:D000379|SNOMEDCT_US:247830007|UMLS:C0001818	hp.json	Fear of open spaces	http://purl.obolibrary.org/obo/HP_0000756		
HP:0000758	biolink:PhenotypicFeature	Abnormal nonverbal communicative behavior	Any abnormal nonverbal communication, such as reduced use of eye-to-eye gaze, atypical facial expressions, body posture, and gestures.	UMLS:C4021798	hp.json	Impaired use of nonverbal behaviours|Impaired use of nonverbal behaviors	http://purl.obolibrary.org/obo/HP_0000758		
HP:0000757	biolink:PhenotypicFeature	Lack of insight		UMLS:C0233824|SNOMEDCT_US:24340004	hp.json	Lack of insight	http://purl.obolibrary.org/obo/HP_0000757		
HP:0000759	biolink:PhenotypicFeature	Abnormal peripheral nervous system morphology	A structural abnormality of the peripheral nervous system, which is composed of the nerves that lead to or branch off from the central nervous system. This includes the cranial nerves (olfactory and optic nerves are technically part of the central nervous system).	SNOMEDCT_US:42658009|MSH:D010523|UMLS:C0031117|UMLS:C4025831|SNOMEDCT_US:302226006	hp.json	Abnormal peripheral nervous system structure|Peripheral nervous system disease	http://purl.obolibrary.org/obo/HP_0000759		
BSPO:0015014	biolink:NamedThing	immediately superficial to	x immediately superficial to y iff x superficial to y and x is contiguous with y.	BSPO:0015014	hp.json		http://purl.obolibrary.org/obo/BSPO_0015014		
HP:0000750	biolink:PhenotypicFeature	Delayed speech and language development	A degree of language development that is significantly below the norm for a child of a specified age.	UMLS:C0233715|UMLS:C0454644|UMLS:C0241210|UMLS:C0023012|SNOMEDCT_US:29164008|SNOMEDCT_US:229721007|SNOMEDCT_US:62415009|SNOMEDCT_US:162294008|MSH:D007805	hp.json	Delayed speech and language development|Language delay|Delayed speech development|Delayed speech|Speech and language difficulties|Language delayed|Impaired speech and language development|Speech delay|Poor speech acquisition|Speech and language delay|Speech difficulties|Poor speech development|Delayed language development|Poor language development|Late-onset speech development|Impaired speech development|Deficiency of speech development|Language development deficit|Delayed speech acquisition	http://purl.obolibrary.org/obo/HP_0000750		
HP:0000752	biolink:PhenotypicFeature	Hyperactivity	Hyperactivity is a state of constantly being unusually or abnormally active, including in situations in which it is not appropriate.	UMLS:C0424295|SNOMEDCT_US:44548000|MSH:D006948	hp.json	Hyperactive behaviour|Hyperactive behavior|More active than typical	http://purl.obolibrary.org/obo/HP_0000752		
HP:0000751	biolink:PhenotypicFeature	Personality changes	An abnormal shift in patterns of thinking, acting, or feeling.	SNOMEDCT_US:192073007|SNOMEDCT_US:102943000|UMLS:C0240735	hp.json	Personality change|Personality changes	http://purl.obolibrary.org/obo/HP_0000751		
HP:0000753	biolink:PhenotypicFeature	Autism with high cognitive abilities		UMLS:C4025832	hp.json		http://purl.obolibrary.org/obo/HP_0000753		
HP:0012745	biolink:PhenotypicFeature	Short palpebral fissure	Distance between the medial and lateral canthi is more than 2 SD below the mean for age (objective); or, apparently reduced length of the palpebral fissures.	UMLS:C0423112|SNOMEDCT_US:246802000	hp.json	Short opening between the eyelids|Decreased height of palpebral fissure|Short palpebral fissures	http://purl.obolibrary.org/obo/HP_0012745		hposlim_core
HP:0012746	biolink:PhenotypicFeature	Thin toenail	Toenail that appears thin when viewed on end.	UMLS:C3554113	hp.json	Thin toenail|Thin toenails	http://purl.obolibrary.org/obo/HP_0012746		
HP:0012747	biolink:PhenotypicFeature	Abnormal brainstem MRI signal intensity	A deviation from normal signal on magnetic resonance imaging (MRI) of the brainstem.	UMLS:C4022749	hp.json		http://purl.obolibrary.org/obo/HP_0012747		
HP:0012748	biolink:PhenotypicFeature	Focal T2 hyperintense brainstem lesion	A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hyperintensity affecting a particular region of the brainstem.	UMLS:C4022748	hp.json		http://purl.obolibrary.org/obo/HP_0012748		
UBERON:0019190	biolink:AnatomicalEntity	mucous gland of lung		FMA:13119|SCTID:88410004|BTO:0004638	hp.json	bronchial mucous gland|peribronchial gland|bronchial gland	http://purl.obolibrary.org/obo/UBERON_0019190		human_reference_atlas
HP:0012749	biolink:PhenotypicFeature	Focal T2 hypointense brainstem lesion	A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a localized hypointensity affecting a particular region of the brainstem.	UMLS:C4022747	hp.json		http://purl.obolibrary.org/obo/HP_0012749		
UBERON:0019189	biolink:AnatomicalEntity	carotid artery endothelium		BTO:0004626	hp.json	carotid epithelium|carotid endothelium	http://purl.obolibrary.org/obo/UBERON_0019189		
HP:0012730	biolink:PhenotypicFeature	Aglossia	Absence of the tongue owing to a developmental abnormality.	SNOMEDCT_US:74788000|UMLS:C0158663	hp.json	Failure of development of tongue|Missing tongue|Absence of tongue	http://purl.obolibrary.org/obo/HP_0012730		
HP:0012731	biolink:PhenotypicFeature	Ectopic anterior pituitary gland	Abnormal anatomic location of the anterior pituitary gland.	UMLS:C4022751	hp.json		http://purl.obolibrary.org/obo/HP_0012731		
HP:0012732	biolink:PhenotypicFeature	Anorectal anomaly	An abnormality of the anus or rectum.	UMLS:C3495676|MSH:D000071056|SNOMEDCT_US:33225004	hp.json		http://purl.obolibrary.org/obo/HP_0012732		
HP:0012733	biolink:PhenotypicFeature	Macule	A flat, distinct, discolored area of skin less than 1 cm wide that does not involve any change in the thickness or texture of the skin.	SNOMEDCT_US:112629002|UMLS:C0332573	hp.json	Flat, discolored area of skin|Flat, discoloured area of skin	http://purl.obolibrary.org/obo/HP_0012733		
HP:0000767	biolink:PhenotypicFeature	Pectus excavatum	A defect of the chest wall characterized by a depression of the sternum, giving the chest ("pectus") a caved-in ("excavatum") appearance.	SNOMEDCT_US:391987005|UMLS:C2051831	hp.json	Funnel chest	http://purl.obolibrary.org/obo/HP_0000767		hposlim_core
HP:0000766	biolink:PhenotypicFeature	Abnormal sternum morphology	An anomaly of the sternum, also known as the breastbone.	UMLS:C1860493	hp.json	Pectus excavatum or carinatum|Sternal anomalies|Abnormality of the sternum|Pectus deformity|Pectus deformities|Pectus carinatum or pectus excavatum|Pectus excavatum or pectus carinatum|Pectus excavatum/carinatum	http://purl.obolibrary.org/obo/HP_0000766		hposlim_core
HP:0000769	biolink:PhenotypicFeature	Abnormality of the breast	An abnormality of the breast.	UMLS:C4025829	hp.json	Abnormality of the breast	http://purl.obolibrary.org/obo/HP_0000769		hposlim_core
HP:0000768	biolink:PhenotypicFeature	Pectus carinatum	A deformity of the chest caused by overgrowth of the ribs and characterized by protrusion of the sternum.	SNOMEDCT_US:205101001|MSH:D066166|UMLS:C0158731	hp.json	Pigeon chest	http://purl.obolibrary.org/obo/HP_0000768		hposlim_core
GO:1904178	biolink:BiologicalProcess	negative regulation of adipose tissue development	Any process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development.		hp.json	down regulation of adipose tissue development|inhibition of adipogenesis|inhibition of adipose tissue development|down-regulation of adipose tissue development|downregulation of adipogenesis|down regulation of adipogenesis|downregulation of adipose tissue development|down-regulation of adipogenesis|negative regulation of adipogenesis	http://purl.obolibrary.org/obo/GO_1904178		
GO:1904177	biolink:BiologicalProcess	regulation of adipose tissue development	Any process that modulates the frequency, rate or extent of adipose tissue development.		hp.json	regulation of adipogenesis	http://purl.obolibrary.org/obo/GO_1904177		
HP:0000763	biolink:PhenotypicFeature	Sensory neuropathy	Peripheral neuropathy affecting the sensory nerves.	UMLS:C0151313|SNOMEDCT_US:95662005	hp.json	Damage to nerves that sense feeling|Peripheral sensory neuropathy	http://purl.obolibrary.org/obo/HP_0000763		
HP:0000762	biolink:PhenotypicFeature	Decreased nerve conduction velocity	A reduction in the speed at which electrical signals propagate along the axon of a neuron.	UMLS:C1857640	hp.json	Slowed nerve conduction velocities|Reduced nerve conduction velocities|Decreased nerve conduction velocities|Decreased NCV|Delayed nerve conduction velocity|Slow nerve conduction velocity	http://purl.obolibrary.org/obo/HP_0000762		
CHEBI:17933	biolink:ChemicalSubstance	calcidiol	A hydroxycalciol that is calciol in which the hydrogen at position 25 has been replaced by a hydroxy group. A prehormone resulting from the oxidation of calciol in the liver, it is further hydroxylated in the kidney to give calcitriol, the active form of vitamin D3.	Drug_Central:464|PMID:22487892|PMID:9080330|DrugBank:DB00146|PDBeChem:VDY|PMID:22536761|PMID:18689406|CAS:19356-17-3|Wikipedia:Calcifediol|LIPID_MAPS_instance:LMST03020246|CAS:19356-17-3|PMID:23566108|PMID:23090338|Reaxys:4270041|Beilstein:4270041|KEGG:C01561|PMID:16549446	hp.json	(3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol|(3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol|25-hydroxyvitamin D3|calcifediol|Calcidiol|(5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-triene-3,25-diol|3-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANOL|(3S,5Z,7E)-9,10-secocholesta-5,7,10-triene-3,25-diol|calcifediol|Calcifediol anhydrous|Calcifediol|25-Hydroxyvitamin D3|calcidiol|25-hydroxycholecalciferol|25(OH)D3|calcifediolum|Rayaldee	http://purl.obolibrary.org/obo/CHEBI_17933		3_STAR
HP:0000765	biolink:PhenotypicFeature	Abnormal thorax morphology	Any abnormality of the thorax (the region of the body formed by the sternum, the thoracic vertebrae and the ribs).	UMLS:C4021797	hp.json	Abnormality of the thorax|Abnormality of the chest|Structural abnormality of the chest wall	http://purl.obolibrary.org/obo/HP_0000765		
GO:1904172	biolink:BiologicalProcess	positive regulation of bleb assembly	Any process that activates or increases the frequency, rate or extent of bleb assembly.		hp.json	upregulation of cell blebbing|up regulation of bleb assembly|activation of bleb assembly|upregulation of bleb assembly|up-regulation of cell blebbing|up regulation of cell blebbing|activation of cell blebbing|positive regulation of cell blebbing|up-regulation of bleb assembly	http://purl.obolibrary.org/obo/GO_1904172		
GO:1904171	biolink:BiologicalProcess	negative regulation of bleb assembly	Any process that stops, prevents or reduces the frequency, rate or extent of bleb assembly.		hp.json	down-regulation of cell blebbing|negative regulation of cell blebbing|down regulation of cell blebbing|down-regulation of bleb assembly|inhibition of cell blebbing|downregulation of cell blebbing|down regulation of bleb assembly|inhibition of bleb assembly|downregulation of bleb assembly	http://purl.obolibrary.org/obo/GO_1904171		
HP:0000764	biolink:PhenotypicFeature	Peripheral axonal degeneration	Progressive deterioration of peripheral axons.	UMLS:C4025830	hp.json		http://purl.obolibrary.org/obo/HP_0000764		
HP:0012734	biolink:PhenotypicFeature	Ketotic hypoglycemia	Low blood glucose is accompanied by elevated levels of ketone bodies in the body.	UMLS:C0271713|SNOMEDCT_US:20825002	hp.json	Ketotic low blood sugar	http://purl.obolibrary.org/obo/HP_0012734		
GO:1904170	biolink:BiologicalProcess	regulation of bleb assembly	Any process that modulates the frequency, rate or extent of bleb assembly.		hp.json	regulation of cell blebbing	http://purl.obolibrary.org/obo/GO_1904170		
HP:0012735	biolink:PhenotypicFeature	Cough	A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.	SNOMEDCT_US:49727002|UMLS:C0010200|SNOMEDCT_US:263731006|SNOMEDCT_US:272039006|MSH:D003371	hp.json	Cough|Coughing	http://purl.obolibrary.org/obo/HP_0012735		
HP:0012736	biolink:PhenotypicFeature	Profound global developmental delay	A profound delay in the achievement of motor or mental milestones in the domains of development of a child.	UMLS:C1855773|UMLS:C3553450	hp.json	Global developmental delay, profound|Psychomotor retardation, profound	http://purl.obolibrary.org/obo/HP_0012736		
HP:0012737	biolink:PhenotypicFeature	Small intestinal polyp	A discrete abnormal tissue mass that protrudes into the lumen of the small intestine and is attached to the intestinal wall either by a stalk, pedunculus, or a broad base.	UMLS:C1302645|SNOMEDCT_US:399723004	hp.json		http://purl.obolibrary.org/obo/HP_0012737		
HP:0012738	biolink:PhenotypicFeature	Agenesis of canine	Agenesis of canine tooth.	UMLS:C4280311|UMLS:C4021072	hp.json	Absence of eye tooth|Absent canines|Failure of development of eye tooth|Missing eye tooth|Missing canine|Failure of development of canine|Absence of canine	http://purl.obolibrary.org/obo/HP_0012738		
HP:0012739	biolink:PhenotypicFeature	Agenesis of the small intestine	Failure to develop of the small intestine.	UMLS:C4021071	hp.json	Small bowel agenesis|Undeveloped small intestine	http://purl.obolibrary.org/obo/HP_0012739		
HP:0012720	biolink:PhenotypicFeature	Neoplasm of the nose	Tumor (An abnormal mass of tissue resulting from abnormally dividing cells) of the nasal cavity.	NCIT:C3262|UMLS:C0751394|MSH:D009669|SNOMEDCT_US:126669004|UMLS:C0028433	hp.json	Nasal tumour|Nose cancer|Nasal tumor|Tumor of the nose|Nasal neoplasm|Tumour of the nose|Neoplasia of the nose	http://purl.obolibrary.org/obo/HP_0012720		
HP:0012721	biolink:PhenotypicFeature	Venous malformation	A vascular malformation resulting from a developmental error of venous tissue composed of dysmorphic channels lined by flattened endothelium and exhibiting slow turnover. A venous malformation may present as a blue patch on the skin ranging to a soft blue mass. Venous malformations are easily compressible and usually swell in thewhen venous pressure increases (e.g., when held in a dependent position or when a child cries). They may be relatively localized or quite extensive within an anatomic region.	UMLS:C2937220|SNOMEDCT_US:297222002	hp.json	Venous malformations	http://purl.obolibrary.org/obo/HP_0012721		
HP:0012722	biolink:PhenotypicFeature	Heart block	Impaired conduction of cardiac impulse occurring anywhere along the conduction pathway.	UMLS:C0018794|SNOMEDCT_US:233916004|MSH:D006327	hp.json		http://purl.obolibrary.org/obo/HP_0012722		
HP:0000734	biolink:PhenotypicFeature	Disinhibition	A lack of restraint manifested in several ways, including disregard for social conventions, impulsivity, and poor risk assessment.	UMLS:C0424296|SNOMEDCT_US:247977003	hp.json	Disinhibition	http://purl.obolibrary.org/obo/HP_0000734		
HP:0000733	biolink:PhenotypicFeature	Motor stereotypy	A stereotypy is a repetitive, simple movement that can be voluntarily suppressed. Stereotypies are typically simple back-and-forth movements such as waving of flapping the hands or arms, and they do not involve complex sequences or movement fragments. Movement is often but not always rhythmic and may involve fingers, wrists, or more proximal portions of the upper extremity. The lower extremity is not typically involved. Stereotypies are more commonly bilateral than unilateral.	SNOMEDCT_US:5507002|MSH:D013239|UMLS:C0038273|SNOMEDCT_US:84328007|UMLS:C0038271|MSH:D019956	hp.json	Stereotypical motor behavior|Stereotypic behavior|Repetitive or self-injurious behavior|Stereotyped, repetitive behaviour|Stereotypic behaviors|Repetitive or self-injurious behaviour|Stereotyped behaviours|Stereotyped behavior|Stereotyped behaviour|Stereotyped behaviors|Stereotypical motor behaviors|Repetitive movements|Stereotyped, repetitive behavior|Stereotypic behaviour|Stereotypical motor behaviours|Stereotypic behaviours	http://purl.obolibrary.org/obo/HP_0000733		
HP:0000736	biolink:PhenotypicFeature	Short attention span	Reduced attention span characterized by distractibility and impulsivity but not necessarily satisfying the diagnostic criteria for attention deficit hyperactivity disorder.	SNOMEDCT_US:247762003|UMLS:C0262630	hp.json	Short attention span|Easily distracted|Poor attention span|Problem paying attention	http://purl.obolibrary.org/obo/HP_0000736		
HP:0000735	biolink:PhenotypicFeature	Impaired social interactions	Difficulty in social interactions related to an impairment of characteristics such as eye contact, smiling, appropriate facial expressions, and body postures and characterized by difficulty in forming peer relationships and forming friendships.	UMLS:C0150080|MSH:D000067404|SNOMEDCT_US:88598008	hp.json	Impaired social interaction|Impaired social interactions|Poor social interactions	http://purl.obolibrary.org/obo/HP_0000735		
HP:0000738	biolink:PhenotypicFeature	Hallucinations	Perceptions in a conscious and awake state in the absence of external stimuli which have qualities of real perception, in that they are vivid, substantial, and located in external objective space.	MSH:D006212|UMLS:C0018524|UMLS:C0235153|SNOMEDCT_US:7011001	hp.json	Hallucinations|Sensory hallucination|Hallucination	http://purl.obolibrary.org/obo/HP_0000738		
HP:0000737	biolink:PhenotypicFeature	Irritability	A proneness to anger, i.e., a condition of being easily bothered or annoyed.	UMLS:C2700617	hp.json	Irritable|Irritability	http://purl.obolibrary.org/obo/HP_0000737		
HP:0000739	biolink:PhenotypicFeature	Anxiety	Intense feelings of nervousness, tenseness, or panic, often in reaction to interpersonal stresses; worry about the negative effects of past unpleasant experiences and future negative possibilities; feeling fearful, apprehensive, or threatened by uncertainty; fears of falling apart or losing control.	UMLS:C4020884|MSH:D001007|SNOMEDCT_US:48694002|UMLS:C0003467	hp.json	Anxiety disease|Anxiousness|Excessive, persistent worry and fear|Anxiety	http://purl.obolibrary.org/obo/HP_0000739		
GO:1904179	biolink:BiologicalProcess	positive regulation of adipose tissue development	Any process that activates or increases the frequency, rate or extent of adipose tissue development.		hp.json	positive regulation of adipogenesis|upregulation of adipose tissue development|up regulation of adipogenesis|up-regulation of adipogenesis|up regulation of adipose tissue development|activation of adipose tissue development|up-regulation of adipose tissue development|activation of adipogenesis|upregulation of adipogenesis	http://purl.obolibrary.org/obo/GO_1904179		
CHEBI:17968	biolink:ChemicalSubstance	butyrate	A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group.	CAS:461-55-2|UM-BBD_compID:c0035|Gmelin:324289|PMID:7496326|KEGG:C00246|PMID:17190852|Reaxys:3601060|Beilstein:3601060|MetaCyc:BUTYRIC_ACID	hp.json	propanecarboxylate|butanoate|n-butanoate|butanoate|butanoate|1-propanecarboxylate|butyrate|butanoic acid, ion(1-)|n-butyrate|CH3-[CH2]2-COO(-)|propylformate|1-butanoate|butanate|1-butyrate	http://purl.obolibrary.org/obo/CHEBI_17968		3_STAR
UBERON:0007197	biolink:AnatomicalEntity	hermaphroditic organism	Multicellular organism that can produce both male and female gametes.	TADS:0000601|WBbt:0007849|BILA:0000029|AAO:0010035|CARO:0000029|HAO:0000029	hp.json	dioecious organism|hermaphrodite	http://purl.obolibrary.org/obo/UBERON_0007197		
UBERON:0007196	biolink:AnatomicalEntity	tracheobronchial tree	The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells.	NCIT:C117875|FMA:7393	hp.json	tracheobronchial system|arbor tracheobronchialis	http://purl.obolibrary.org/obo/UBERON_0007196		organ_slim|pheno_slim
HP:0000732	biolink:PhenotypicFeature	Inflexible adherence to routines or rituals		UMLS:C1837653	hp.json		http://purl.obolibrary.org/obo/HP_0000732		
UBERON:0007195	biolink:AnatomicalEntity	stroma of bone marrow	The stroma of the bone marrow is all tissue not directly involved in the primary function of hematopoiesis. The yellow bone marrow belongs here, and makes the majority of the bone marrow stroma, in addition to stromal cells located in the red bone marrow. Yellow bone marrow is found in the Medullary cavity. Still, the stroma is indirectly involved in hematopoiesis, since it provides the hematopoietic microenvironment that facilitates hematopoiesis by the parenchymal cells. For instance, they generate colony stimulating factors, affecting hematopoiesis.	CALOHA:TS-0085|FMA:21426|Wikipedia:Bone_marrow#Stroma	hp.json	bone marrow stroma	http://purl.obolibrary.org/obo/UBERON_0007195		
HP:0012723	biolink:PhenotypicFeature	Sinoatrial block	Disturbance in the atrial activation that is caused by transient failure of impulse conduction from the sinoatrial node to the cardiac atria.	UMLS:C0037188|SNOMEDCT_US:65778007|Fyler:7014|MSH:D012848	hp.json		http://purl.obolibrary.org/obo/HP_0012723		
HP:0012724	biolink:PhenotypicFeature	Upper eyelid edema	Edema in the region of the upper eyelid.	UMLS:C2025988|SNOMEDCT_US:700339006|UMLS:C3839407	hp.json	Upper eyelid oedema|Cellulitis of upper eyelid|Swelling of upper eyelid|Puffiness of upper eyelid|Fullness of upper eyelid	http://purl.obolibrary.org/obo/HP_0012724		
HP:0012725	biolink:PhenotypicFeature	Cutaneous syndactyly	A soft tissue continuity in the A/P axis between two digits that extends distally to at least the level of the proximal interphalangeal joints, or a soft tissue continuity in the A/P axis between two digits that lies significantly distal to the flexion crease that overlies the metacarpophalangeal or metatarsophalangeal joint of the adjacent digits.	UMLS:C1861921	hp.json	Cutaneous syndactyly of digits|Syndactyly, cutaneous	http://purl.obolibrary.org/obo/HP_0012725		
HP:0012726	biolink:PhenotypicFeature	Episodic hypokalemia	An abnormally decreased potassium concentration in the blood occurring periodically with a return to normal between the episodes.	UMLS:C4022754	hp.json	Recurrent low potassium	http://purl.obolibrary.org/obo/HP_0012726		
HP:0012727	biolink:PhenotypicFeature	Thoracic aortic aneurysm	An abnormal localized widening (dilatation) of the thoracic aorta.	SNOMEDCT_US:433068007|UMLS:C0162872|MSH:D017545	hp.json	Dilatation of the thoracic aorta	http://purl.obolibrary.org/obo/HP_0012727		
HP:0012728	biolink:PhenotypicFeature	Fusiform descending thoracic aortic aneurysm	A concentric abnormal localized widening (dilatation) of the descending thoracic aorta that involves the full circumference of the vessel wall	UMLS:C4022753	hp.json	Dilatation of the fusiform descending thoracic aorta	http://purl.obolibrary.org/obo/HP_0012728		
HP:0012729	biolink:PhenotypicFeature	Saccular descending thoracic aortic aneurysm	An eccentric abnormal localized widening (dilatation) of the descending thoracic aorta that involves only a portion of the circumference of the vessel wall	UMLS:C4022752	hp.json	Dilatation of the saccular descending thoracic aorta	http://purl.obolibrary.org/obo/HP_0012729		
OBO:nbo#qualifier	biolink:NamedThing	qualifier			hp.json		http://purl.obolibrary.org/obo/nbo#qualifier		
CHEBI:30911	biolink:ChemicalSubstance	glucitol		Beilstein:1721909|Gmelin:83165|Wikipedia:Sorbitol	hp.json	rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol|glucitol|Sorbitol|gulitol	http://purl.obolibrary.org/obo/CHEBI_30911		3_STAR
HP:0012710	biolink:PhenotypicFeature	Ingrown nail	Excessive growth of a nail laterally into the nail fold.	UMLS:C0027343|SNOMEDCT_US:400097005|SNOMEDCT_US:400200009|MSH:D009263	hp.json	Ingrown nail	http://purl.obolibrary.org/obo/HP_0012710		
HP:0012711	biolink:PhenotypicFeature	Delayed ossification of vertebral epiphysis	A delay in the process of formation and maturation of the epiphysis of one or more vertebrae.	UMLS:C4022759|UMLS:C4280312	hp.json	Delayed maturation of the end part of the vertebral bone	http://purl.obolibrary.org/obo/HP_0012711		
CHEBI:29922	biolink:ChemicalSubstance	sulfo group		PDBeChem:SFO	hp.json	sulfo|hydroxydioxo-lambda(6)-sulfanyl|hydroxysulfonyl|-S(O)2(OH)|SULFO GROUP	http://purl.obolibrary.org/obo/CHEBI_29922		3_STAR
HP:0000745	biolink:PhenotypicFeature	Diminished motivation	A reduction in goal-directed behavior, that is, motivation, the determinant of behavior and adaptation that allows individuals to get started, be energized to perform a sustained and directed action.	UMLS:C0456814|SNOMEDCT_US:277521002	hp.json	Lacking in initiative|Lack of motivation|Lacks initiative|Diminished motivation|Lack of initiative	http://purl.obolibrary.org/obo/HP_0000745		
HP:0000744	biolink:PhenotypicFeature	Low frustration tolerance	The feeling of frustration can be defined as an emotional reaction that occurs if a desired goal is not achieved. Frustration intolerance is defined as an age-inappropriate response to frustration characterized by crying or temper tantrums (in children) or aggressive or other undesirable behaviors.	UMLS:C0548883	hp.json	Intolerance to frustration	http://purl.obolibrary.org/obo/HP_0000744		
UBERON:0007182	biolink:AnatomicalEntity	muscle layer of infundibulum of uterine tube	A muscle layer that is part of a uterine tube infundibulum.	EMAPA:31264|FMA:18336	hp.json	muscle layer of infundibulum of fallopian tube|muscle layer of infundibulum of oviduct|muscularis of infundibulum of uterine tube	http://purl.obolibrary.org/obo/UBERON_0007182		
UBERON:0007181	biolink:AnatomicalEntity	serosa of infundibulum of uterine tube	A serous membrane that is part of a uterine tube infundibulum.	EMAPA:29903|FMA:18324	hp.json	serosa of infundibulum of oviduct|serosa of infundibulum of fallopian tube	http://purl.obolibrary.org/obo/UBERON_0007181		
HP:0000746	biolink:PhenotypicFeature	Delusions	A false belief that is held despite evidence to the contrary.	MSH:D003702|SNOMEDCT_US:2073000|UMLS:C0011253	hp.json	Delusions	http://purl.obolibrary.org/obo/HP_0000746		
HP:0000749	biolink:PhenotypicFeature	Paroxysmal bursts of laughter		UMLS:C1839749	hp.json	Paroxysmal laughter	http://purl.obolibrary.org/obo/HP_0000749		
HP:0000748	biolink:PhenotypicFeature	Inappropriate laughter		SNOMEDCT_US:247985007|UMLS:C0424304	hp.json	Inappropriate laughter	http://purl.obolibrary.org/obo/HP_0000748		
CHEBI:30916	biolink:ChemicalSubstance	2-oxoglutarate(1-)	A dicarboxylic acid monoanion resulting from selective deprotonation of the 1-carboxy group of 2-oxoglutaric acid.	Gmelin:2159365|Beilstein:4132418|Reaxys:4132418	hp.json	2-ketoglutarate|4-carboxy-2-oxobutanoate	http://purl.obolibrary.org/obo/CHEBI_30916		3_STAR
CHEBI:30915	biolink:ChemicalSubstance	2-oxoglutaric acid	An oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle.	Wikipedia:Alpha-Ketoglutaric_acid|PMID:21964641|Reaxys:1705689|Beilstein:1705689|CAS:328-50-7|PMID:20200292|KEGG:C00026|HMDB:HMDB0000208|DrugBank:DB02926|PMID:20155414|PMID:20583149|CAS:328-50-7|CAS:328-50-7|PMID:17439666|MetaCyc:2-KETOGLUTARATE|PMID:18990406|KNApSAcK:C00000769|Gmelin:602480|PDBeChem:AKG|PMID:20636327	hp.json	alpha-ketoglutaric acid|alpha-Ketoglutaric acid|Oxoglutaric acid|2-oxopentanedioic acid|2-Ketoglutaric acid	http://purl.obolibrary.org/obo/CHEBI_30915		3_STAR
CHEBI:66916	biolink:ChemicalSubstance	alanine zwitterion	An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of alanine; major species at pH 7.3.		hp.json	2-azaniumylpropanoate|2-ammoniopropanoate	http://purl.obolibrary.org/obo/CHEBI_66916		3_STAR
UBERON:0007188	biolink:AnatomicalEntity	mesothelium of serous pericardium	A mesothelium that is part of a serous pericardium.	FMA:18149|EMAPA:16133|SCTID:67300002|BTO:0003157	hp.json	mesothelium of pericardium|pericardial mesothelium|serous pericardium mesothelium	http://purl.obolibrary.org/obo/UBERON_0007188		
HP:0000741	biolink:PhenotypicFeature	Apathy		UMLS:C0085632|MSH:D057565|SNOMEDCT_US:20602000	hp.json	Lack of feeling, emotion, interest	http://purl.obolibrary.org/obo/HP_0000741		
HP:0000740	biolink:PhenotypicFeature	Episodic paroxysmal anxiety	Recurrent attacks of severe anxiety, whose occurence is not restricted to any particular situation or set of circumstances and is therefore unpredictable.	UMLS:C1854339	hp.json		http://purl.obolibrary.org/obo/HP_0000740		
HP:0000743	biolink:PhenotypicFeature	Frontal release signs	Primitive reflexes traditionally held to be a sign of disorders that affect the frontal lobes.	UMLS:C1833297	hp.json	Frontal release reflexes	http://purl.obolibrary.org/obo/HP_0000743		
HP:0000742	biolink:PhenotypicFeature	Self-mutilation		SNOMEDCT_US:130968006|MSH:D012652|UMLS:C0036601	hp.json	Self mutilation|Deliberate self-harm|Self-mutilation	http://purl.obolibrary.org/obo/HP_0000742		
HP:0012712	biolink:PhenotypicFeature	Mild hearing impairment	The presence of a mild form of hearing impairment.	UMLS:C4022758	hp.json	Mild hearing impairment	http://purl.obolibrary.org/obo/HP_0012712		
HP:0012713	biolink:PhenotypicFeature	Moderate hearing impairment	The presence of a moderate form of hearing impairment.	UMLS:C4022757	hp.json	Moderate hearing impairment	http://purl.obolibrary.org/obo/HP_0012713		
HP:0012714	biolink:PhenotypicFeature	Severe hearing impairment	A severe form of hearing impairment.	SNOMEDCT_US:3561000119106|UMLS:C3874334	hp.json	Severe hearing loss|Severe deafness|Severe hearing impairment	http://purl.obolibrary.org/obo/HP_0012714		
HP:0012715	biolink:PhenotypicFeature	Profound hearing impairment	A profound (essentially complete) form of hearing impairment.	UMLS:C4022756	hp.json	Profound hearing impairment	http://purl.obolibrary.org/obo/HP_0012715		
HP:0012716	biolink:PhenotypicFeature	Moderate conductive hearing impairment	The presence of a moderate form of conductive hearing impairment.	UMLS:C4021075	hp.json	Conductive hearing loss, moderate	http://purl.obolibrary.org/obo/HP_0012716		
HP:0012717	biolink:PhenotypicFeature	Severe conductive hearing impairment	A severe form of conductive hearing impairment.	UMLS:C4021074	hp.json	Conductive hearing loss, severe	http://purl.obolibrary.org/obo/HP_0012717		
HP:0012718	biolink:PhenotypicFeature	Morphological abnormality of the gastrointestinal tract	Abnormal structure of the gastrointestinal tract.	UMLS:C4021073	hp.json	Morphological anomaly of the digestive system|Abnormal shape of the digestive system|Morphological abnormality of the GI tract	http://purl.obolibrary.org/obo/HP_0012718		
HP:0012719	biolink:PhenotypicFeature	Functional abnormality of the gastrointestinal tract	Abnormal functionality of the gastrointestinal tract.	UMLS:C4022755	hp.json	Functional abnormality of the GI tract|GI dysfunction	http://purl.obolibrary.org/obo/HP_0012719		
HP:0012781	biolink:PhenotypicFeature	Mid-frequency hearing loss	A type of hearing impairment affecting primarily the middle frequencies of sound (1000 Hz to 3000 Hz).	UMLS:C4022723	hp.json		http://purl.obolibrary.org/obo/HP_0012781		
HP:0012782	biolink:PhenotypicFeature	Perilobar nephrogenic rest	A type of nephrogenic rest associated with multiple lesions in the periphery of the renal lobe.	SNOMEDCT_US:405935000|UMLS:C1319017	hp.json	Perilobar nephrogenic rests	http://purl.obolibrary.org/obo/HP_0012782		
HP:0012783	biolink:PhenotypicFeature	Intralobar nephrogenic rest	A type of nephrogenic rest usually representing single lesions within the renal lobe, renal sinus, or calyceal walls.	SNOMEDCT_US:405934001|UMLS:C1319016	hp.json	Intralobar nephrogenic rests	http://purl.obolibrary.org/obo/HP_0012783		
HP:0009131	biolink:PhenotypicFeature	Abnormality of the musculature of the thorax	A disease or lesion affecting the muscles of the thorax.	UMLS:C4024580	hp.json		http://purl.obolibrary.org/obo/HP_0009131		
HP:0012784	biolink:PhenotypicFeature	Perinephritis	Inflammation of the connective and adipose tissues surrounding the kidney.	UMLS:C0031065|SNOMEDCT_US:111404004|MSH:D010501	hp.json		http://purl.obolibrary.org/obo/HP_0012784		
HP:0009130	biolink:PhenotypicFeature	Hand muscle atrophy	Muscular atrophy involving the muscles of the hand.	UMLS:C0239830	hp.json	Hand muscle degeneration|Amyotrophy of hand muscles|Amyotrophy involving the musculature of the hand|Hand muscle wasting|Hand muscle wasting, bilateral	http://purl.obolibrary.org/obo/HP_0009130		
HP:0012785	biolink:PhenotypicFeature	Flexion contracture of finger	Chronic loss of joint motion in a finger due to structural changes in non-bony tissue.	UMLS:C1857304	hp.json	Flexion deformity of finger	http://purl.obolibrary.org/obo/HP_0012785		
HP:0012786	biolink:PhenotypicFeature	Recurrent cystitis	Repeated infections of the urinary bladder.	SNOMEDCT_US:197853008|UMLS:C0581366	hp.json	Recurrent bladder infections	http://purl.obolibrary.org/obo/HP_0012786		
HP:0012787	biolink:PhenotypicFeature	Recurrent pyelonephritis	Repeated episodes of pyelonephritis.	UMLS:C0748199	hp.json		http://purl.obolibrary.org/obo/HP_0012787		
HP:0012788	biolink:PhenotypicFeature	Reticulate pigmentation of oral mucosa	A net-like pattern of increased pigmentation of the oral cavity.	UMLS:C1852148	hp.json	Reticulate pigmentation of oral mucous membrane|Mottled pigmentation of oral mucosa	http://purl.obolibrary.org/obo/HP_0012788		
HP:0010126	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the hallux	In contrast to the metatarsals 2-5, the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the big toe is equivalent to the middle phalanges of the other digits. This term applies to abnormalities affecting the proximal phalanx of the hallux.	UMLS:C4024033	hp.json	Abnormality of the end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010126		
HP:0010125	biolink:PhenotypicFeature	Abnormality of the epiphysis of the 1st metatarsal	In contrast to the metatarsals 2-5, the first metatarsal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5, whereas the proximal phalanx of the big toe is equivalent to the middle phalanges of the other digits. This term applies to abnormalities of the epiphysis of the first metatarsal bone.	UMLS:C4024034	hp.json	Abnormality of the end part of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010125		
HP:0000799	biolink:PhenotypicFeature	Renal steatosis	Abnormal fat accumulation in the kidneys.	UMLS:C4021796	hp.json	Fatty kidney	http://purl.obolibrary.org/obo/HP_0000799		
HP:0010124	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the hallux		UMLS:C4024035	hp.json	Abnormality of the end part of the outermost bone of the big toe bone	http://purl.obolibrary.org/obo/HP_0010124		
HP:0010123	biolink:PhenotypicFeature	Triangular epiphyses of the hallux		UMLS:C4024036	hp.json	Triangular end part of the big toe bone	http://purl.obolibrary.org/obo/HP_0010123		
HP:0010122	biolink:PhenotypicFeature	Stippling of the epiphyses of the hallux	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the hallux.	UMLS:C4024037	hp.json	Speckled calcifications in the end part of the big toe bone	http://purl.obolibrary.org/obo/HP_0010122		
HP:0010121	biolink:PhenotypicFeature	Small epiphyses of the hallux		UMLS:C4024038	hp.json	Small end part of the big toe bone	http://purl.obolibrary.org/obo/HP_0010121		
HP:0010120	biolink:PhenotypicFeature	Pseudoepiphyses of the hallux		UMLS:C4024039	hp.json		http://purl.obolibrary.org/obo/HP_0010120		
HP:0012780	biolink:PhenotypicFeature	Neoplasm of the ear	A tumor (abnormal growth of tissue) of the ear.	NCIT:C3262|MSH:D004428|UMLS:C0013449|SNOMEDCT_US:363228008	hp.json	Ear tumour|Ear tumor	http://purl.obolibrary.org/obo/HP_0012780		
HP:0000791	biolink:PhenotypicFeature	Uric acid nephrolithiasis	The presence of uric acid-containing calculi (stones) in the kidneys.	SNOMEDCT_US:267441009|UMLS:C0403719	hp.json	Uric acid urolithiasis|Uric acid stones	http://purl.obolibrary.org/obo/HP_0000791		
HP:0000794	biolink:PhenotypicFeature	IgA deposition in the glomerulus	The presence of immunoglobulin A deposits in the glomerulus.	SNOMEDCT_US:236407003|UMLS:C4025827|UMLS:C0017661|SNOMEDCT_US:68779003|MSH:D005922	hp.json	IgA nephropathy	http://purl.obolibrary.org/obo/HP_0000794		
HP:0000793	biolink:PhenotypicFeature	Membranoproliferative glomerulonephritis	A type of glomerulonephritis characterized by diffuse mesangial cell proliferation and the thickening of capillary walls due to subendothelial extension of the mesangium. The term membranoproliferative glomerulonephritis is often employed to denote a general pattern of glomerular injury seen in a variety of disease processes that share a common pathogenetic mechanism, rather than to describe a single disease entity	MSH:D015432|SNOMEDCT_US:80321008|UMLS:C0017662	hp.json	MPGN|Mesangiocapillary glomerulonephritis	http://purl.obolibrary.org/obo/HP_0000793		
HP:0000796	biolink:PhenotypicFeature	Urethral obstruction	Obstruction of the flow of urine through the urethra.	SNOMEDCT_US:95588004|MSH:D014524|UMLS:C0041972	hp.json		http://purl.obolibrary.org/obo/HP_0000796		
HP:0009129	biolink:PhenotypicFeature	Upper limb amyotrophy	Muscular atrophy involving the muscles of the upper limbs.	UMLS:C4021523	hp.json	Amyotrophy involving the upper limbs	http://purl.obolibrary.org/obo/HP_0009129		
HP:0000795	biolink:PhenotypicFeature	Abnormality of the urethra	An abnormality of the urethra, i.e., of the tube which connects the urinary bladder to the outside of the body.	UMLS:C4025826	hp.json	Urethra issue	http://purl.obolibrary.org/obo/HP_0000795		
CHEBI:66922	biolink:ChemicalSubstance	citrullinate	An alpha-amino acid anion that is the conjugate base of citrulline, obtained by deprotonation of the carboxy group.		hp.json	2-amino-5-(carbamoylamino)pentanoate	http://purl.obolibrary.org/obo/CHEBI_66922		3_STAR
HP:0010129	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the hallux		UMLS:C4024030	hp.json	Cone-shaped end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010129		
HP:0000798	biolink:PhenotypicFeature	Oligospermia	Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen.	MSH:D009845|UMLS:C0028960	hp.json	Low sperm count	http://purl.obolibrary.org/obo/HP_0000798		
OBO:uberon/core#protects	biolink:NamedThing	protects			hp.json		http://purl.obolibrary.org/obo/uberon/core#protects		
HP:0010128	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the hallux	The epiphysis of the proximal phalanx of the hallux surrounds the diaphysis, having a bracket-like form.	UMLS:C4024031	hp.json	Bracket shaped end part of the innermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010128		
CHEBI:66924	biolink:ChemicalSubstance	creatinate	A monocarboxylic acid anion that is the conjugate base of creatine, obtained by deprotonation of the carboxy group.		hp.json	N-[amino(imino)methyl]-N-methylglycinate|(N-methylcarbamimidamido)acetate|{[imino(amino)methyl](methyl)amino}acetate	http://purl.obolibrary.org/obo/CHEBI_66924		3_STAR
HP:0010127	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the hallux	Failure to form (agenesis) of the epiphysis of the proximal phalanx of the hallux.	UMLS:C4024032	hp.json	Absent end part of the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010127		
HP:0012789	biolink:PhenotypicFeature	Hypoplasia of the calcaneus	Underdevelopment of the heel bone.	UMLS:C3550873	hp.json	Underdeveloped heel bone|Hypoplastic calcaneus|Small heel bone	http://purl.obolibrary.org/obo/HP_0012789		
HP:0009126	biolink:PhenotypicFeature	Increased adipose tissue	An increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell).	UMLS:C4024583	hp.json	Increased fat tissue|Increased adipose tissue	http://purl.obolibrary.org/obo/HP_0009126		
HP:0009125	biolink:PhenotypicFeature	Lipodystrophy	Degenerative changes of the fat tissue.	MSH:D008060|UMLS:C0023787|SNOMEDCT_US:71325002	hp.json	Inability to make and keep healthy fat tissue	http://purl.obolibrary.org/obo/HP_0009125		
HP:0009128	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the musculature of the extremities		UMLS:C4024581	hp.json	Absent/underdeveloped muscles of extremities|Absent/small muscles of extremities	http://purl.obolibrary.org/obo/HP_0009128		
HP:0009127	biolink:PhenotypicFeature	Abnormality of the musculature of the limbs		UMLS:C4024582	hp.json	Abnormal limb muscles|Muscle issues in the arms and/or legs	http://purl.obolibrary.org/obo/HP_0009127		
HP:0009122	biolink:PhenotypicFeature	Aplasia/hypoplasia affecting bones of the axial skeleton	Absence (due to failure to form) or underdevelopment of bones of the axial skeleton.	UMLS:C4024585	hp.json		http://purl.obolibrary.org/obo/HP_0009122		
HP:0009121	biolink:PhenotypicFeature	Abnormal axial skeleton morphology	An abnormality of the axial skeleton, which comprises the skull, the vertebral column, the ribs and the sternum.	UMLS:C4020785|UMLS:C4024586	hp.json	Abnormality of the axial skeleton	http://purl.obolibrary.org/obo/HP_0009121		
HP:0009124	biolink:PhenotypicFeature	Abnormal adipose tissue morphology	An abnormality of adipose tissue, which is loose connective tissue composed of adipocytes.	UMLS:C4021524	hp.json	Abnormality of fat tissue|Abnormality of adipose tissue|Abnormality of fatty tissue	http://purl.obolibrary.org/obo/HP_0009124		
HP:0000790	biolink:PhenotypicFeature	Hematuria	The presence of blood in the urine. Hematuria may be gross hematuria (visible to the naked eye) or microscopic hematuria (detected by dipstick or microscopic examination of the urine).	UMLS:C0018965|SNOMEDCT_US:53298000|SNOMEDCT_US:34436003|MSH:D006417	hp.json	Blood in urine|High urine occult blood	http://purl.obolibrary.org/obo/HP_0000790		
HP:0009123	biolink:PhenotypicFeature	Mixed hypo- and hyperpigmentation of the skin		UMLS:C4024584	hp.json		http://purl.obolibrary.org/obo/HP_0009123		
HP:0012770	biolink:PhenotypicFeature	Reduced arm span	Decreased length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle).	UMLS:C4022730	hp.json	Reduced arm span	http://purl.obolibrary.org/obo/HP_0012770		
HP:0009140	biolink:PhenotypicFeature	Synostosis involving bones of the feet		UMLS:C4024575	hp.json	Fusion involving the bones of the feet	http://purl.obolibrary.org/obo/HP_0009140		
HP:0012771	biolink:PhenotypicFeature	Increased arm span	Increased length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle).	UMLS:C4022729	hp.json	Increased arm span	http://purl.obolibrary.org/obo/HP_0012771		
HP:0012772	biolink:PhenotypicFeature	Abnormal upper to lower segment ratio	A deviation from normal of the relation between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis.	UMLS:C4022728	hp.json		http://purl.obolibrary.org/obo/HP_0012772		
HP:0009142	biolink:PhenotypicFeature	Duplication of bones involving the upper extremities		UMLS:C4024574	hp.json	Duplication of bones involving the upper extremities	http://purl.obolibrary.org/obo/HP_0009142		
HP:0009141	biolink:PhenotypicFeature	Depletion of mitochondrial DNA in muscle tissue		UMLS:C4021521	hp.json	Depletion of mitochondrial dna in skeletal muscle tissue	http://purl.obolibrary.org/obo/HP_0009141		
HP:0012773	biolink:PhenotypicFeature	Reduced upper to lower segment ratio	Decreased ratio between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis. Consider the term Disproportionate tall stature (HP:0001519) if tall stature is also present.	UMLS:C1836996	hp.json		http://purl.obolibrary.org/obo/HP_0012773		
HP:0012774	biolink:PhenotypicFeature	Increased upper to lower segment ratio	Elevated ratio between the upper and the lower segment of the body, where the lower segment is defined as the length between the top of pubic symphysis to floor, and the upper segment is defined as the top of head to top of pubic symphysis.	UMLS:C1844571	hp.json		http://purl.obolibrary.org/obo/HP_0012774		
HP:0012775	biolink:PhenotypicFeature	Stellate iris	A lacy pattern or iris pigmentation that resembles the spokes of a bicycle wheel.	UMLS:C4022727	hp.json		http://purl.obolibrary.org/obo/HP_0012775		
HP:0012776	biolink:PhenotypicFeature	Abnormal ciliary body morphology	A structural anomaly of the ciliary body.	UMLS:C4022726	hp.json	Abnormality of the ciliary body	http://purl.obolibrary.org/obo/HP_0012776		
HP:0012777	biolink:PhenotypicFeature	Retinal neoplasm	A tumor (abnormal growth of tissue) of the retina.	UMLS:C0524801|NCIT:C3262|MSH:D019572|SNOMEDCT_US:127002001	hp.json		http://purl.obolibrary.org/obo/HP_0012777		
HP:0010115	biolink:PhenotypicFeature	Cone-shaped epiphyses of the hallux		UMLS:C4024044	hp.json	Cone-shaped end part of the big toe bone	http://purl.obolibrary.org/obo/HP_0010115		
HP:0010114	biolink:PhenotypicFeature	Bracket epiphyses of the hallux		UMLS:C4024045	hp.json	Bracket shaped end part of big toe bone	http://purl.obolibrary.org/obo/HP_0010114		
HP:0010113	biolink:PhenotypicFeature	Absent hallux epiphysis	Failure to form (agenesis) of one or more epiphyses of the big toe.	UMLS:C4020906	hp.json	Absent end part of big toe bone|Absent epiphyses of the hallux	http://purl.obolibrary.org/obo/HP_0010113		
HP:0010112	biolink:PhenotypicFeature	Mesoaxial foot polydactyly	The presence of a supernumerary toe (not a hallux) involving the third or fourth metatarsal with associated osseous syndactyly.	UMLS:C4021333	hp.json	Central polydactyly of feet	http://purl.obolibrary.org/obo/HP_0010112		hposlim_core
HP:0010111	biolink:PhenotypicFeature	Short phalanx of hallux	Underdevelopment (hypoplasia) of a phalanx of big toe.	UMLS:C4021334	hp.json	Hypoplastic phalanges of the hallux|Short bone of big toe	http://purl.obolibrary.org/obo/HP_0010111		
HP:0010110	biolink:PhenotypicFeature	Aplasia of the phalanges of the hallux		UMLS:C4024046	hp.json	Absent bone of big toe	http://purl.obolibrary.org/obo/HP_0010110		
HP:0010119	biolink:PhenotypicFeature	Ivory epiphyses of the hallux		UMLS:C4024040	hp.json	Increased bone density of end part of the big toe bone	http://purl.obolibrary.org/obo/HP_0010119		
CHEBI:66933	biolink:ChemicalSubstance	N-alkylglycine	Any glycine derivative in which glycine is substituted at position 2 by an alkyl group.	PMID:9989229|MetaCyc:N-Alkylglycine	hp.json	N-alkylglycines	http://purl.obolibrary.org/obo/CHEBI_66933		3_STAR
HP:0010118	biolink:PhenotypicFeature	Irregular epiphyses of the hallux		UMLS:C4024041	hp.json	Irregular end part of big toe bone	http://purl.obolibrary.org/obo/HP_0010118		
HP:0010117	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the hallux		UMLS:C4024042	hp.json	Fragmentation of the end part of the big toe bone	http://purl.obolibrary.org/obo/HP_0010117		
HP:0010116	biolink:PhenotypicFeature	Enlarged epiphyses of the hallux		UMLS:C4024043	hp.json	Enlarged end part of the big toe bone	http://purl.obolibrary.org/obo/HP_0010116		
HP:0012778	biolink:PhenotypicFeature	Retinal astrocytic hamartoma	A glial tumor of the retinal nerve fiber layer arising from a retinal astrocyte.	UMLS:C4022725	hp.json		http://purl.obolibrary.org/obo/HP_0012778		
HP:0009136	biolink:PhenotypicFeature	Duplication involving bones of the feet		UMLS:C4024578	hp.json	Duplication involving bones of the feet	http://purl.obolibrary.org/obo/HP_0009136		
HP:0012779	biolink:PhenotypicFeature	Transient hearing impairment	Hearing loss that occurs acutely and resolves completely.	UMLS:C4022724	hp.json		http://purl.obolibrary.org/obo/HP_0012779		
HP:0009139	biolink:PhenotypicFeature	Osteolysis involving bones of the lower limbs		UMLS:C4024576	hp.json		http://purl.obolibrary.org/obo/HP_0009139		
HP:0009138	biolink:PhenotypicFeature	Synostosis involving bones of the lower limbs	An abnormal union between bones or parts of bones lower limbs.	UMLS:C4024577	hp.json	Fusion involving the bones of the lower limbs	http://purl.obolibrary.org/obo/HP_0009138		
HP:0009132	biolink:PhenotypicFeature	Abnormal tarsal bone mineral density	This term applies to all changes in bone mineral density of the tarsal bones, which (depending on severity) can be seen on x-rays as a change in density and or structure of the bone.	UMLS:C4021522	hp.json	Abnormality of bone mineral density involving tarsal bones	http://purl.obolibrary.org/obo/HP_0009132		
HP:0009134	biolink:PhenotypicFeature	Osteolysis involving bones of the feet		UMLS:C4024579	hp.json		http://purl.obolibrary.org/obo/HP_0009134		
HP:0012760	biolink:PhenotypicFeature	Impaired social reciprocity	A reduced ability to participate in the back and forth flow of social interaction, which is normally characterized by an influence of the behavior of one person on the behavior of another person who is in conversation with the first.	UMLS:C4022736	hp.json		http://purl.obolibrary.org/obo/HP_0012760		
HP:0012761	biolink:PhenotypicFeature	Absent mastoid	A developmental anomaly in which the mastoid process fails to form and is thus found to be congenitally absent.	UMLS:C4021070	hp.json	Failure of development of mastoid|Mastoid agenesis|Absent mastoids	http://purl.obolibrary.org/obo/HP_0012761		
HP:0012762	biolink:PhenotypicFeature	Cerebral white matter atrophy	The presence of atrophy (wasting) of the cerebral white matter.	UMLS:C4022735	hp.json		http://purl.obolibrary.org/obo/HP_0012762		
HP:0012763	biolink:PhenotypicFeature	Paroxysmal dyspnea	A sudden attack of dyspnea that occurs while the affected person is at rest.	SNOMEDCT_US:59265000|MSH:D004418|UMLS:C0013405	hp.json	Paroxysmal dyspnoea	http://purl.obolibrary.org/obo/HP_0012763		
HP:0012764	biolink:PhenotypicFeature	Orthopnea	A sensation of breathlessness in the recumbent position, relieved by sitting or standing.	UMLS:C0085619|SNOMEDCT_US:62744007	hp.json		http://purl.obolibrary.org/obo/HP_0012764		
HP:0012765	biolink:PhenotypicFeature	Widened cerebellar subarachnoid space	An increase in size of the anatomic space between the arachnoid membrane and pia mater in the region surrounding the cerebellum.	UMLS:C4022734	hp.json		http://purl.obolibrary.org/obo/HP_0012765		
HP:0012766	biolink:PhenotypicFeature	Widened cerebral subarachnoid space	An increase in size of the anatomic space between the arachnoid membrane and pia mater in the region surrounding the cerebrum.	UMLS:C4022733	hp.json		http://purl.obolibrary.org/obo/HP_0012766		
HP:0010104	biolink:PhenotypicFeature	Absent first metatarsal	A developmental defect characterized by the absence of the first metatarsal bone.	UMLS:C1863382	hp.json	Aplasia of the 1st metatarsal|Absent 1st metatarsal|Absent 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010104		
HP:0000778	biolink:PhenotypicFeature	Hypoplasia of the thymus	Underdevelopment of the thymus.	UMLS:C4228227|UMLS:C0685891|SNOMEDCT_US:93297002	hp.json	Thymus hypoplasia|Small thymus|Thymic hypoplasia	http://purl.obolibrary.org/obo/HP_0000778		
HP:0010103	biolink:PhenotypicFeature	Short distal phalanx of hallux	Underdevelopment (hypoplasia) of the distal phalanx of big toe.	UMLS:C4021335	hp.json	Small distal phalanx of big toe|Small outermost bone of big toe|Small distal phalanx of hallux|Hypoplastic/small distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010103		
HP:0000777	biolink:PhenotypicFeature	Abnormality of the thymus	Abnormality of the thymus, an organ located in the upper anterior portion of the chest cavity just behind the sternum and whose main function is to provide an environment for T lymphocyte maturation.	UMLS:C0262650|UMLS:C0685891|SNOMEDCT_US:93297002	hp.json	Abnormality of the thymus	http://purl.obolibrary.org/obo/HP_0000777		
HP:0010102	biolink:PhenotypicFeature	Aplasia of the distal phalanx of the hallux		UMLS:C4024048	hp.json	Absent outermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010102		
HP:0010101	biolink:PhenotypicFeature	Partial duplication of the phalanges of the hallux		UMLS:C1855005	hp.json	Partial duplication of big toe|partial duplication of hallux	http://purl.obolibrary.org/obo/HP_0010101		
HP:0010100	biolink:PhenotypicFeature	Complete duplication of hallux phalanx	Complete duplication of one or more phalanx of big toe.	UMLS:C4021336	hp.json	Complete duplication of the phalanges of the hallux|Complete duplication of big toe bones	http://purl.obolibrary.org/obo/HP_0010100		
HP:0000772	biolink:PhenotypicFeature	Abnormal rib morphology	An anomaly of the rib.	UMLS:C1842083	hp.json	Abnormality of the ribs|Rib anomalies|Rib abnormalities	http://purl.obolibrary.org/obo/HP_0000772		hposlim_core
CHEBI:17924	biolink:ChemicalSubstance	D-glucitol	The D-enantiomer of glucitol (also known as D-sorbitol).	Drug_Central:2462|KNApSAcK:C00001173|CAS:50-70-4|PPDB:1320|PMID:23683321|PMID:16901854|HMDB:HMDB0000247|CAS:50-70-4|PMID:25568069|Reaxys:1721899|Beilstein:1721899|KEGG:D00096|Gmelin:83162|PMID:25108762|Wikipedia:Sorbitol|PMID:17979222|PMID:24643482|PMID:22735334|PMID:22878210|Beilstein:4656395|PMID:19695255|PMID:31537530|PMID:17336832|PDBeChem:SOR|CAS:50-70-4|KEGG:C00794|PMID:19443021|DrugBank:DB01638	hp.json	D-Sorbit|E 420|D-glucitol|D-Sorbitol|G-ol|(-)-sorbitol|D-Glucitol|D-SORBITOL|D-sorbitol|E420|L-Gulitol|Glc-ol|(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol|D-(-)-sorbitol|E-420	http://purl.obolibrary.org/obo/CHEBI_17924		3_STAR
HP:0010109	biolink:PhenotypicFeature	Short hallux	Underdevelopment (hypoplasia) of the big toe.	UMLS:C1865992	hp.json	Small hallux|Short big toe|Hypoplastic hallux|Short halluces|Hypoplastic big toes	http://purl.obolibrary.org/obo/HP_0010109		
HP:0000771	biolink:PhenotypicFeature	Gynecomastia	Abnormal development of large mammary glands in males resulting in breast enlargement.	UMLS:C0018418|MSH:D006177|SNOMEDCT_US:4754008	hp.json	Enlarged male breast|Gynaecomastia	http://purl.obolibrary.org/obo/HP_0000771		hposlim_core
HP:0009108	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the femoral head and neck		UMLS:C4024594	hp.json	Absent/underdeveloped head and neck of thighbone|Absent/small head and neck of thighbone	http://purl.obolibrary.org/obo/HP_0009108		
HP:0000774	biolink:PhenotypicFeature	Narrow chest	Reduced width of the chest from side to side, associated with a reduced distance from the sternal notch to the tip of the shoulder.	UMLS:C0426790|SNOMEDCT_US:249671009	hp.json	Reduced anterior-posterior chest diameter|Low chest circumference|Narrow shoulders|Narrow chest|Narrow thorax	http://purl.obolibrary.org/obo/HP_0000774		
HP:0010107	biolink:PhenotypicFeature	Short proximal phalanx of hallux	Underdevelopment (hypoplasia) of the proximal phalanx of big toe.	UMLS:C1862159	hp.json	Short proximal phalanx of halluces|Short proximal phalanges of halluces|Small proximal phalanx of hallux|Short innermost big toe bone|Hypoplastic proximal phalanx of the hallux|Small proximal phalanx of big toe	http://purl.obolibrary.org/obo/HP_0010107		
HP:0000773	biolink:PhenotypicFeature	Short ribs	Reduced rib length.	UMLS:C0426817|SNOMEDCT_US:249696007	hp.json	Rib hypoplasia|Hypoplastic ribs|Short ribs	http://purl.obolibrary.org/obo/HP_0000773		
HP:0009107	biolink:PhenotypicFeature	Abnormal ossification involving the femoral head and neck		UMLS:C4024595	hp.json	Abnormal maturation of thigh bone head and neck	http://purl.obolibrary.org/obo/HP_0009107		
HP:0000776	biolink:PhenotypicFeature	Congenital diaphragmatic hernia	The presence of a hernia of the diaphragm present at birth.	MSH:D065630|UMLS:C0235833|SNOMEDCT_US:17190001	hp.json	Diaphragmatic hernia	http://purl.obolibrary.org/obo/HP_0000776		
HP:0010106	biolink:PhenotypicFeature	Aplasia of the proximal phalanx of the hallux		UMLS:C4024047	hp.json	Absent innermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010106		
HP:0010105	biolink:PhenotypicFeature	Short first metatarsal	Short first metatarsal bone.	UMLS:C1841688	hp.json	First metatarsal hypoplasia|Short 1st long bone of foot|First metatarsals hypoplastic	http://purl.obolibrary.org/obo/HP_0010105		
HP:0000775	biolink:PhenotypicFeature	Abnormality of the diaphragm	Any abnormality of the diaphragm, the sheet of skeletal muscle that separates the thoracic cavity from the abdominal cavity.	UMLS:C1848873	hp.json	Abnormality of the diaphragm|Diaphragmatic defect|Diaphragm issues	http://purl.obolibrary.org/obo/HP_0000775		
HP:0009109	biolink:PhenotypicFeature	Denervation of the diaphragm	Interruption of the innervation of the diaphragm.	UMLS:C1858529	hp.json		http://purl.obolibrary.org/obo/HP_0009109		
HP:0012767	biolink:PhenotypicFeature	Abnormal placental size	A deviation from normal size of the placenta.	UMLS:C4022732	hp.json		http://purl.obolibrary.org/obo/HP_0012767		
HP:0009104	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the pubic bone	Absence or underdevelopment of the pubic bone.	UMLS:C1849305	hp.json	Absent/underdeveloped pubic bones|Absent/small pubic bones|Hypoplastic/aplastic pubic bones	http://purl.obolibrary.org/obo/HP_0009104		
HP:0009103	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the pelvis		UMLS:C4024597	hp.json	Absent/underdeveloped pelvis|Absent/small pelvis	http://purl.obolibrary.org/obo/HP_0009103		
HP:0012768	biolink:PhenotypicFeature	Neonatal asphyxia	Respiratory failure in the newborn.	SNOMEDCT_US:28314004|UMLS:C0004045|SNOMEDCT_US:413654009|MSH:D001238	hp.json	Asphyxia neonatorum	http://purl.obolibrary.org/obo/HP_0012768		
HP:0009106	biolink:PhenotypicFeature	Abnormal pelvis bone ossification	An abnormality of the formation and mineralization of any bone of the bony pelvis.	UMLS:C4280402|UMLS:C4021525	hp.json	Abnormal maturation of the pelvis bone|Abnormal ossification involving the bones of the pelvis	http://purl.obolibrary.org/obo/HP_0009106		
HP:0012769	biolink:PhenotypicFeature	Abnormal arm span	A deviation from normal of the length of the arm span (length from one end of an individual's arms measured at the fingertips to the other when raised parallel to the ground at shoulder height at a one-hundred eighty degree angle)	UMLS:C4022731	hp.json	Abnormal arm span	http://purl.obolibrary.org/obo/HP_0012769		
HP:0009105	biolink:PhenotypicFeature	Abnormal ossification of the pubic bone	Abnormal ossification (bone tissue formation) affecting the pubic bone, also known as the pubis.	UMLS:C4024596|UMLS:C4280403	hp.json	Abnormal maturation of the pubic bone	http://purl.obolibrary.org/obo/HP_0009105		
HP:0009100	biolink:PhenotypicFeature	Thick anterior alveolar ridges		UMLS:C1859377	hp.json	Thick anterior alveolar process of jaw	http://purl.obolibrary.org/obo/HP_0009100		
HP:0009102	biolink:PhenotypicFeature	Anterior open-bite malocclusion	Anterior open bite is a malocclusion characterized by a gap between the anterior teeth (incisors), that is, by a deficiency in the normal vertical overlap between antagonist incisal edges when the posterior teeth are in occlusion.	UMLS:C4024598	hp.json	Anterior openbite|Anterior open bite|Apertognathia malocclusion|AOB|Absence of overlap of anterior upper and lower teeth|Gap between upper and lower front teeth when biting|Anterior open bite between upper and lower teeth	http://purl.obolibrary.org/obo/HP_0009102		
HP:0009101	biolink:PhenotypicFeature	Submucous cleft lip	A cleft of the lip with overlying mucous membrane.	UMLS:C1839277	hp.json	Submucous labial cleft	http://purl.obolibrary.org/obo/HP_0009101		
HP:0012750	biolink:PhenotypicFeature	T2 hypointense brainstem	A darker than expected T2 signal on magnetic resonance imaging (MRI) of the brainstem. This term refers to a diffuse hypointensity affecting the entire brainstem.	UMLS:C4022746	hp.json		http://purl.obolibrary.org/obo/HP_0012750		
HP:0009120	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the sinuses	Absence or underdevelopment of a cranial sinus or sinuses.	UMLS:C4024587	hp.json		http://purl.obolibrary.org/obo/HP_0009120		
HP:0012751	biolink:PhenotypicFeature	Abnormal basal ganglia MRI signal intensity	A deviation from normal signal on magnetic resonance imaging (MRI) of the basal ganglia.	UMLS:C4022745	hp.json		http://purl.obolibrary.org/obo/HP_0012751		
HP:0012752	biolink:PhenotypicFeature	Focal T2 hypointense basal ganglia lesion	A darker than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a localized hypointensity affecting a particular region of the basal ganglia.	UMLS:C4022744	hp.json		http://purl.obolibrary.org/obo/HP_0012752		
HP:0012753	biolink:PhenotypicFeature	T2 hypointense basal ganglia	A darker than expected T2 signal on magnetic resonance imaging (MRI) of the basal ganglia. This term refers to a diffuse hypointensity affecting all of the basal ganglia.	UMLS:C4022743	hp.json		http://purl.obolibrary.org/obo/HP_0012753		
HP:0012754	biolink:PhenotypicFeature	CNS hypermyelination	Increased amount of myelin in the central nervous system.	UMLS:C4022742	hp.json		http://purl.obolibrary.org/obo/HP_0012754		
HP:0012755	biolink:PhenotypicFeature	Enlarged brainstem	Abnormal increase in size of the brainstem.	UMLS:C4022741	hp.json		http://purl.obolibrary.org/obo/HP_0012755		
HP:0000789	biolink:PhenotypicFeature	Infertility		UMLS:C0021359|SNOMEDCT_US:15296000|MSH:D007246|SNOMEDCT_US:8619003	hp.json	Infertility	http://purl.obolibrary.org/obo/HP_0000789		
HP:0000782	biolink:PhenotypicFeature	Abnormal scapula morphology	Any abnormality of the scapula, also known as the shoulder blade.	UMLS:C4025828	hp.json	Abnormality of the shoulder blade	http://purl.obolibrary.org/obo/HP_0000782		hposlim_core
HP:0009119	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the frontal sinuses	Absence or underdevelopment of frontal sinus.	UMLS:C4024588	hp.json	Abnormally small frontal sinus	http://purl.obolibrary.org/obo/HP_0009119		
HP:0009118	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the mandible	Absence or underdevelopment of the mandible.	UMLS:C4280401|UMLS:C3494426|UMLS:C4024589|UMLS:C4280261|MSH:D063173|UMLS:C4021371	hp.json		http://purl.obolibrary.org/obo/HP_0009118		
HP:0000787	biolink:PhenotypicFeature	Nephrolithiasis	The presence of calculi (stones) in the kidneys.	MSH:D053040|UMLS:C0392525	hp.json	Renal stones|Kidney stones|Renal calculi	http://purl.obolibrary.org/obo/HP_0000787		
HP:0000786	biolink:PhenotypicFeature	Primary amenorrhea		SNOMEDCT_US:8913004|UMLS:C0232939	hp.json		http://purl.obolibrary.org/obo/HP_0000786		
HP:0009115	biolink:PhenotypicFeature	Aplasia/hypoplasia involving the skeleton	Absence (due to failure to form) or underdevelopment of one or more components of the skeleton.	UMLS:C4024592	hp.json	Absent/small skeleton|Absent/underdeveloped skeleton	http://purl.obolibrary.org/obo/HP_0009115		
HP:0012756	biolink:PhenotypicFeature	CSF polymorphonuclear pleocytosis	An increased polymorphonuclear cell count in the cerebrospinal fluid.	UMLS:C4022740	hp.json		http://purl.obolibrary.org/obo/HP_0012756		
HP:0012757	biolink:PhenotypicFeature	Abnormal neuron morphology	A structural anomaly of a neuron. Neurons are electrically excitable cells that transmit signals throughout the body. Neurons employ both electrical and chemical components in the transmission of information. Neurons are connected to other neurons at synapses and connected to effector organs or cells at neuroeffector junctions.	UMLS:C4022739	hp.json	Abnormal neuronal morphology|Abnormal neuron shape	http://purl.obolibrary.org/obo/HP_0012757		
HP:0009117	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the maxilla	Absence or underdevelopment of the maxilla.	UMLS:C4024590	hp.json	Underdevelopment of upper jaw bones|Underdevelopment of maxilla	http://purl.obolibrary.org/obo/HP_0009117		
HP:0012758	biolink:PhenotypicFeature	Neurodevelopmental delay	Neurodevelopmental delay (NDD) refers to delays in the maturation of the brain and central nervous system; infants and young children with NDD may experience delays in the development of one or more skills including gross motor abilities, fine-motor coordination, language abilities and ability to solve increasingly complex problems.	UMLS:C4022738	hp.json	NDD	http://purl.obolibrary.org/obo/HP_0012758		
HP:0009116	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving bones of the skull		UMLS:C4024591	hp.json		http://purl.obolibrary.org/obo/HP_0009116		
HP:0012759	biolink:PhenotypicFeature	Neurodevelopmental abnormality	A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities.	UMLS:C4022737	hp.json		http://purl.obolibrary.org/obo/HP_0012759		
HP:0009110	biolink:PhenotypicFeature	Diaphragmatic eventration	A congenital failure of muscular development of part or all of one or both hemidiaphragms, resulting in superior displacement of abdominal viscera and altered lung development.	MSH:D003965|UMLS:C0011981|SNOMEDCT_US:34168003	hp.json	Eventration of the diaphragm	http://purl.obolibrary.org/obo/HP_0009110		
HP:0009113	biolink:PhenotypicFeature	Diaphragmatic weakness	A decrease in the strength of the diaphragm.	UMLS:C4020786|SNOMEDCT_US:95438009|UMLS:C0521532	hp.json	Diaphragmatic paraparesis|Weak diaphragm|Diminished diaphragmatic motion	http://purl.obolibrary.org/obo/HP_0009113		
HP:0009112	biolink:PhenotypicFeature	Aplasia of the left hemidiaphragm	Congenital absence of the left half of the diaphragm.	UMLS:C4024593	hp.json	Left diaphragmatic hernia|Absent left hemidiaphragm	http://purl.obolibrary.org/obo/HP_0009112		
CL:0000402	biolink:Cell	CNS interneuron			hp.json		http://purl.obolibrary.org/obo/CL_0000402		
CL:0000404	biolink:Cell	electrically signaling cell	A cell that initiates an electrical signal and passes that signal to another cell.		hp.json		http://purl.obolibrary.org/obo/CL_0000404		
CL:0000408	biolink:Cell	male gamete		BTO:0001277|CALOHA:TS-0949	hp.json		http://purl.obolibrary.org/obo/CL_0000408		
UBERON:0007135	biolink:AnatomicalEntity	neural keel	An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section.	TAO:0000131|EFO:0003497|ZFA:0000131	hp.json	presumptive central nervous system	http://purl.obolibrary.org/obo/UBERON_0007135		efo_slim
UBERON:0007134	biolink:AnatomicalEntity	trunk ganglion	Ganglion which is located in the trunk.	TAO:0001573|MIAA:0000344|EFO:0000901|ZFA:0001573|MAT:0000344	hp.json	body ganglion|trunk ganglia	http://purl.obolibrary.org/obo/UBERON_0007134		efo_slim
CHEBI:15366	biolink:ChemicalSubstance	acetic acid	A simple monocarboxylic acid containing two carbons.	KEGG:C00033|PMID:12005138|PMID:19416101|CAS:64-19-7|PDBeChem:ACT|CAS:64-19-7|PMID:15107950|KEGG:D00010|PMID:22173419|LIPID_MAPS_instance:LMFA01010002|HMDB:HMDB0000042|PMID:19469536|MetaCyc:ACET|Gmelin:1380|Beilstein:506007|PDBeChem:ACY|CAS:64-19-7|KNApSAcK:C00001176|PMID:16630552|Reaxys:506007|PMID:22153255|PPDB:1333|Wikipedia:Acetic_acid|PMID:16774200|PMID:17190852|Drug_Central:4211	hp.json	INS No. 260|E260|acide acetique|CH3-COOH|E-260|Essigsaeure|acetic acid|Methanecarboxylic acid|E 260|Ethanoic acid|CH3CO2H|MeCOOH|Acetic acid|ethoic acid|Ethylic acid|AcOH|MeCO2H|ACETIC ACID|HOAc	http://purl.obolibrary.org/obo/CHEBI_15366		3_STAR
CHEBI:15361	biolink:ChemicalSubstance	pyruvate	A 2-oxo monocarboxylic acid anion that is the conjugate base of pyruvic acid, arising from deprotonation of the carboxy group.	PMID:21823181|UM-BBD_compID:c0159|PMID:22215378|PMID:22458763|PMID:21603897|PMID:21854850|PMID:22451307|CAS:57-60-3|PMID:22006570|PMID:22016370|PMID:22311625|PMID:17190852|KEGG:C00022|Gmelin:2502|Reaxys:3587721|Beilstein:3587721	hp.json	2-oxopropanoate|2-oxopropanoic acid, ion(1-)|2-oxopropanoate|pyruvate	http://purl.obolibrary.org/obo/CHEBI_15361		3_STAR
CHEBI:27369	biolink:ChemicalSubstance	zwitterion	A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer).		hp.json	compose zwitterionique|zwitterions|zwitterionic compounds|zwitterion|zwitteriones|compuestos zwitterionicos	http://purl.obolibrary.org/obo/CHEBI_27369		3_STAR
CL:0000413	biolink:Cell	haploid cell	A cell whose nucleus contains a single haploid genome.		hp.json		http://purl.obolibrary.org/obo/CL_0000413		
UBERON:0034762	biolink:AnatomicalEntity	areolar sweat gland	Any sweat gland that is part of an areola.	FMA:62149	hp.json	sweat gland of areola|areolar aprocine sweat gland	http://purl.obolibrary.org/obo/UBERON_0034762		
CL:0000417	biolink:Cell	endopolyploid cell			hp.json		http://purl.obolibrary.org/obo/CL_0000417		
UBERON:0034763	biolink:AnatomicalEntity	hindbrain commissure	Any commissure within the hindbrain.	ZFA:0001692|TAO:0002199	hp.json		http://purl.obolibrary.org/obo/UBERON_0034763		
CHEBI:27363	biolink:ChemicalSubstance	zinc atom		CAS:7440-66-6|CAS:7440-66-6|WebElements:Zn|Gmelin:16321|KEGG:C00038|PDBeChem:ZN	hp.json	Zn|zinc|Zn2+|30Zn|Zink|Zn(II)|zincum|cinc|zinc	http://purl.obolibrary.org/obo/CHEBI_27363		3_STAR
UBERON:0034765	biolink:AnatomicalEntity	glabella skin	The zone of skin that overlaps with the glabella region.		hp.json	glabella	http://purl.obolibrary.org/obo/UBERON_0034765		
UBERON:0007125	biolink:AnatomicalEntity	pharyngeal pouch 4	A pharyngeal pouch between pharyngeal arch 4 and arch 5 or 6 (a fifth arch never establishes in amniotes).	TAO:0001134|FMA:295688|VHOG:0000578|RETIRED_EHDAA2:0000090|VHOG:0000971|EMAPA:16766|NCIT:C34181|EHDAA2:0000091|UMLS:C0231071|XAO:0000254|AAO:0011117|ZFA:0001134|EFO:0003637	hp.json	4th arch branchial pouch|4th arch branchial pouch endoderm|fourth arch pharyngeal pouch|fourth branchial pouch|4th branchial pouch|fourth pharyngeal pouch|4th pharyngeal pouch endoderm|fourth visceral pouch|pharyngeal pouches 4|visceral pouch 4	http://purl.obolibrary.org/obo/UBERON_0007125		pheno_slim|efo_slim|vertebrate_core
UBERON:0007124	biolink:AnatomicalEntity	pharyngeal pouch 3	A pharyngeal pouch that between pharyngeal arches 3 and 4.	ZFA:0001131|NCIT:C34311|VHOG:0000966|EFO:0003634|Wikipedia:Pharyngeal_pouch_(embryology)#Third_pouch|EHDAA2:0000077|TAO:0001131|FMA:295682|UMLS:C0231070|EMAPA:16586|VHOG:0001030|RETIRED_EHDAA2:0000076|SCTID:345450001|AAO:0011116|XAO:0000251	hp.json	3rd pharyngeal pouch endoderm|third visceral pouch|3rd arch branchial pouch|third arch pharyngeal pouch|3rd branchial pouch|visceral pouch 3|third pharyngeal pouch|3rd arch branchial pouch endoderm|pharyngeal pouches 3	http://purl.obolibrary.org/obo/UBERON_0007124		pheno_slim|efo_slim|vertebrate_core
UBERON:0007123	biolink:AnatomicalEntity	pharyngeal pouch 2	A pharyngeal puch that is between the pharyngeal arches 2 and 3.	NCIT:C34289|ZFA:0001130|FMA:295676|RETIRED_EHDAA2:0000060|EFO:0003633|TAO:0001130|UMLS:C0231069|SCTID:345349000|XAO:0000247|VHOG:0000561|EMAPA:16276|Wikipedia:Pharyngeal_pouch_(embryology)#Second_pouch|EMAPA:16275|VHOG:0000967|EHDAA2:0000058|AAO:0011115	hp.json	pharyngeal pouches 2|visceral pouch 2|2nd pharyngeal pouch endoderm|2nd arch branchial pouch|2nd branchial pouch|2nd arch branchial pouch endoderm|second visceral pouch|second pharyngeal pouch|second arch pharyngeal pouch|2nd arch pouch endoderm	http://purl.obolibrary.org/obo/UBERON_0007123		pheno_slim|efo_slim|vertebrate_core
UBERON:0007122	biolink:AnatomicalEntity	pharyngeal pouch 1	A pharyngeal pouch that is between pharyngeal arches 1 and 2.	SCTID:345248006|AAO:0011114|NCIT:C34176|EFO:0003631|UMLS:C0231068|VHOG:0000555|VHOG:0000970|ZFA:0001128|Wikipedia:Pharyngeal_pouch_(embryology)#First_pouch|XAO:0000102|EMAPA:16125|EMAPA:16124|TAO:0001128|EHDAA2:0000016|FMA:295668	hp.json	visceral pouch 1|1st arch branchial pouch|first visceral pouch|1st arch pouch endoderm|1st arch branchial pouch endoderm|hyomandibular pouch|pharyngeal pouches 1|1st branchial pouch|first arch pharyngeal pouch|1st pharyngeal pouch endoderm|first pharyngeal pouch	http://purl.obolibrary.org/obo/UBERON_0007122		pheno_slim|efo_slim|vertebrate_core
UBERON:0007120	biolink:AnatomicalEntity	premolar tooth	The premolar teeth or bicuspids are transitional teeth located between the canine and molar teeth.	UMLS:C1704302|GAID:1261|NCIT:C32201|FMA:55637|MESH:D001641	hp.json	secondary premolar tooth|bicuspid tooth|bicuspid teeth|premolar|biscuspid|mandibular bicuspid|dentes premolares|maxillary premolar|præmolares|praemolares|bicuspids|dentes premolares|bicuspid|premolar teeth|premolar tooth|maxillary bicuspid|pm3 (dentistry)|dens premolaris|premolars	http://purl.obolibrary.org/obo/UBERON_0007120		pheno_slim
CHEBI:15356	biolink:ChemicalSubstance	cysteine	A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	KNApSAcK:C00001351|KNApSAcK:C00007323|Gmelin:2933|PMID:17439666|Reaxys:1721406|Beilstein:1721406|PMID:25181601|CAS:3374-22-9|CAS:3374-22-9|KEGG:C00736|CAS:3374-22-9|Wikipedia:Cysteine	hp.json	Zystein|cysteine|Hcys|2-amino-3-sulfanylpropanoic acid|C|cysteine|Cystein|cisteina|Cysteine|2-amino-3-mercaptopropanoic acid|Cys|2-Amino-3-mercaptopropionic acid	http://purl.obolibrary.org/obo/CHEBI_15356		3_STAR
CL:0000412	biolink:Cell	polyploid cell	A cell whose nucleus, or nuclei, each contain more than two haploid genomes.		hp.json		http://purl.obolibrary.org/obo/CL_0000412		
UBERON:0007128	biolink:AnatomicalEntity	glomeral mesenchyme	Portion of tissue that consists of the precursors of the pronephric glomus or glomerulus; derived from the medial portion of the pronephric intermediate mesoderm.	XAO:0000110	hp.json	glomerulus|corpuscle	http://purl.obolibrary.org/obo/UBERON_0007128		
CHEBI:29994	biolink:ChemicalSubstance	D-aspartate(2-)	An aspartate(2-) that is the conjugate base of D-aspartate(1-).	Reaxys:14495011|Gmelin:327368	hp.json	(2R)-2-aminobutanedioate|D-aspartate|(2R)-2-aminosuccinate|D-aspartate(2-)|D-aspartic acid dianion	http://purl.obolibrary.org/obo/CHEBI_29994		3_STAR
CHEBI:29993	biolink:ChemicalSubstance	L-aspartate(2-)	An aspartate(2-) that is the conjugate base of  L-aspartate(1-).	Gmelin:327367|Beilstein:4133557|Reaxys:4133557	hp.json	L-aspartate(2-)|(2S)-2-aminobutanedioate|(2S)-2-aminosuccinate|L-aspartic acid dianion|L-aspartate	http://purl.obolibrary.org/obo/CHEBI_29993		3_STAR
CHEBI:29995	biolink:ChemicalSubstance	aspartate(2-)	A C4-dicarboxylate that is the dianion obtained by the deprotonation of both the carboxy groups of aspartic acid.		hp.json	aspartate(2-)|2-aminosuccinate|aspartic acid dianion|2-aminobutanedioate|aspartate	http://purl.obolibrary.org/obo/CHEBI_29995		3_STAR
CHEBI:29990	biolink:ChemicalSubstance	D-aspartate(1-)	An aspartate(1-) that is the conjugate base of D-aspartic acid.	Beilstein:8316944|Reaxys:8316944	hp.json	hydrogen D-aspartate|D-aspartate|D-aspartate(1-)|(2R)-2-ammoniobutanedioate|D-aspartic acid monoanion|(2R)-2-ammoniosuccinate	http://purl.obolibrary.org/obo/CHEBI_29990		3_STAR
UBERON:0010760	biolink:AnatomicalEntity	supraglenoid tubercle	The supraglenoid tubercle is a region of the scapula to which the long head of the biceps brachii muscle attaches.	FMA:23263	hp.json	supraglenoid tuberosity|tuberculum supraglenoidale	http://purl.obolibrary.org/obo/UBERON_0010760		
CHEBI:29991	biolink:ChemicalSubstance	L-aspartate(1-)	An aspartate(1-) that is the  conjugate base of L-aspartic acid.	Reaxys:15801578|Gmelin:327374	hp.json	L-aspartate(1-)|L-aspartic acid monoanion|hydrogen L-aspartate|(2S)-2-ammoniobutanedioate|(2S)-2-ammoniosuccinate|L-aspartate|L-aspartate	http://purl.obolibrary.org/obo/CHEBI_29991		3_STAR
UBERON:0010755	biolink:AnatomicalEntity	secondary follicle corona	The part of the secondary follicle that surrounds the germinal center.	NCIT:C33053|UMLS:C1512987	hp.json	B cell corona|mantle zone|dark zone of follicle|inactive zone of follicle|peripheral zone of follicle	http://purl.obolibrary.org/obo/UBERON_0010755		
CHEBI:39317	biolink:ChemicalSubstance	growth regulator	Any chemical substance that inhibits the life-cycle of an organism.		hp.json	growth regulators	http://purl.obolibrary.org/obo/CHEBI_39317		3_STAR
UBERON:0034766	biolink:AnatomicalEntity	glabella region	A region of the forehead corresponding to the space between the eyebrows and above the nose.		hp.json	glabella	http://purl.obolibrary.org/obo/UBERON_0034766		
GO:1904100	biolink:BiologicalProcess	positive regulation of protein O-linked glycosylation	Any process that activates or increases the frequency, rate or extent of protein O-linked glycosylation.		hp.json	up regulation of protein amino acid O-linked glycosylation|upregulation of protein O-linked glycosylation|positive regulation of protein amino acid O-linked glycosylation|activation of protein amino acid O-linked glycosylation|upregulation of protein amino acid O-linked glycosylation|up regulation of protein O-linked glycosylation|up-regulation of protein O-linked glycosylation|activation of protein O-linked glycosylation|up-regulation of protein amino acid O-linked glycosylation	http://purl.obolibrary.org/obo/GO_1904100		
UBERON:0009778	biolink:AnatomicalEntity	pleural sac	A serous sac that has the pleura and the pleural cavity as parts.	FMA:9690|SCTID:361996004|EHDAA2:0004737	hp.json		http://purl.obolibrary.org/obo/UBERON_0009778		non_informative
UBERON:0010753	biolink:AnatomicalEntity	lymph node secondary follicle	A secondary follicle that is located in a lymph node.	MA:0000744|EMAPA:35531|FMA:312352	hp.json		http://purl.obolibrary.org/obo/UBERON_0010753		human_reference_atlas|pheno_slim
UBERON:0034768	biolink:AnatomicalEntity	morphological feature	A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034768		
UBERON:0010754	biolink:AnatomicalEntity	germinal center	A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center.	EV:0100051|UMLS:C0282491|BTO:0003671|NCIT:C13337|MESH:D018858	hp.json	light zone of follicle|nodule|lymhpoid nodule|central zone of follice|reaction center of follicle	http://purl.obolibrary.org/obo/UBERON_0010754		
UBERON:0034769	biolink:AnatomicalEntity	lymphomyeloid tissue		FMA:79770|NCIT:C41168	hp.json		http://purl.obolibrary.org/obo/UBERON_0034769		
UBERON:0010758	biolink:AnatomicalEntity	subdivision of organism along appendicular axis	A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg.	FBbt:00007018	hp.json	appendicular segment|appendage segment	http://purl.obolibrary.org/obo/UBERON_0010758		upper_level
UBERON:0007119	biolink:AnatomicalEntity	neck of femur	The femur neck or neck of the femur is a flattened pyramidal process of bone, connecting the femoral head with the femoral shaft, and forming with the latter a wide angle opening medialward.	NCIT:C61563|GAID:201|UMLS:C0015815|galen:NeckOfFemur|FMA:42385|MESH:D005272	hp.json	femoral neck|collum femoris|neck of the femur|femur neck	http://purl.obolibrary.org/obo/UBERON_0007119		pheno_slim
UBERON:0007118	biolink:AnatomicalEntity	umbilicus	The pit in the center of the abdominal wall marking the point where the umbilical cord entered in the fetus.	GAID:29|NCIT:C77533|FMA:61584|galen:Umbilicus|UMLS:C0041638|MESH:D014472	hp.json	umbilical region|umbilical part of abdomen|navel	http://purl.obolibrary.org/obo/UBERON_0007118		pheno_slim
UBERON:0009773	biolink:AnatomicalEntity	renal tubule	A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.		hp.json	renal tubule (generic)|tubule of excretory system	http://purl.obolibrary.org/obo/UBERON_0009773		pheno_slim|grouping_class
UBERON:0007116	biolink:AnatomicalEntity	primary dentition	The set of teeth first in order or time of development that will be replaced by permanent dentition upon their loss.	GAID:1252|MESH:D014094|FMA:75151	hp.json	primary teeth|tooth of primary dentition|milk teeth|primary teeth|set of deciduous teeth|deciduous dentition|set of primary teeth|baby teeth|deciduous teeth|dentes decidui	http://purl.obolibrary.org/obo/UBERON_0007116		pheno_slim
UBERON:0007115	biolink:AnatomicalEntity	deciduous tooth	One of the first set of teeth in the growth development of humans and many other mammals[WP].	UMLS:C0040455|FMA:55655|GAID:1266|MESH:D014094|NCIT:C33745	hp.json	primary tooth|temporary tooth|dentes decidui	http://purl.obolibrary.org/obo/UBERON_0007115		pheno_slim
UBERON:0010751	biolink:AnatomicalEntity	squamous part of temporal bone primordium		EHDAA:9536|EHDAA2:0001907	hp.json	squamosal primordium|squamosal bone primordium	http://purl.obolibrary.org/obo/UBERON_0010751		
UBERON:0010744	biolink:AnatomicalEntity	sacral vertebra pre-cartilage condensation	A sacral vertebra endochondral element that is composed primarily of a pre-cartilage condensation.	EMAPA:17677|EHDAA2:0001774	hp.json	sacral vertebral pre-cartilage condensation group	http://purl.obolibrary.org/obo/UBERON_0010744		
UBERON:0010745	biolink:AnatomicalEntity	sacral vertebra cartilage element	A sacral vertebra endochondral element that is composed primarily of cartilage tissue.	EHDAA2:0001773|EMAPA:18009	hp.json	sacral vertebral cartilage condensation|sacral vertebral cartilage condensation group	http://purl.obolibrary.org/obo/UBERON_0010745		
UBERON:0009767	biolink:AnatomicalEntity	proximal interphalangeal joint	An inter-phalangeal joint that connects a proximal phalanx to either a medial or distal phalanx.	NCIT:C101528|FMA:65022	hp.json	PIJ joint|PIP joint	http://purl.obolibrary.org/obo/UBERON_0009767		pheno_slim
UBERON:0010742	biolink:AnatomicalEntity	bone of pelvic complex	A bone that is part of a pelvic complex. Examples: pubis, ischium, fot phalanx, any tarsal bone, any bone of the pelvic fin or girdle.	EMAPA:32633|MA:0000660|EMAPA:35934	hp.json	hindlimb bone	http://purl.obolibrary.org/obo/UBERON_0010742		pheno_slim
UBERON:0009768	biolink:AnatomicalEntity	distal interphalangeal joint	An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx.	FMA:65024|NCIT:C101529	hp.json	DIJ joint|DIP joint	http://purl.obolibrary.org/obo/UBERON_0009768		pheno_slim
UBERON:0007100	biolink:AnatomicalEntity	primary circulatory organ	A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].	SPD:0000130|TADS:0000147|http://www.sciencemag.org/content/313/5795/1922/F1.large.jpg	hp.json	heart|adult heart|dorsal tube|dorsal tube	http://purl.obolibrary.org/obo/UBERON_0007100		grouping_class
UBERON:0010743	biolink:AnatomicalEntity	meningeal cluster	The collection of all meningeal layers that line a central nervous system.	UMLS:C0228116|EHDAA2:0004661|EMAPA:32660|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1465|FMA:231572|NCIT:C12349|Wikipedia:Meninges|SCTID:362879001	hp.json	cluster of meninges|meninges|cerebral meninges	http://purl.obolibrary.org/obo/UBERON_0010743		pheno_slim
CHEBI:15379	biolink:ChemicalSubstance	dioxygen		CAS:7782-44-7|PDBeChem:OXY|HMDB:HMDB0001377|CAS:7782-44-7|Gmelin:485|CAS:7782-44-7|PMID:10906528|KEGG:C00007|Wikipedia:Oxygen|PMID:19840863|MolBase:750|PMID:9463773|PMID:7710549|MetaCyc:OXYGEN-MOLECULE|PMID:18638417|PMID:18210929|KEGG:D00003|PMID:16977326	hp.json	E948|dioxygen|Oxygen|E-948|O2|O2|E 948|molecular oxygen|dioxygene|Disauerstoff|[OO]|O2|OXYGEN MOLECULE	http://purl.obolibrary.org/obo/CHEBI_15379		3_STAR
UBERON:0010748	biolink:AnatomicalEntity	lymph node follicle	A lymphoid follicle that is part of a lymph node.	EMAPA:35527|MA:0000742	hp.json	follicle of lymph node	http://purl.obolibrary.org/obo/UBERON_0010748		
UBERON:0010746	biolink:AnatomicalEntity	iliac blade	The extension of the ilium above the level of the acetabulum. Attachment site for both hindlimb and caudal musculature. Medially is the site of attachment of the sacral ribs, where these exist[PHENOSCAPE:ad].	FMA:42826	hp.json	wing of ilium|a. ossis ilii|ala ossis ilii|ilium ala|wing of the ilium|ala of ilium	http://purl.obolibrary.org/obo/UBERON_0010746		pheno_slim
UBERON:0010747	biolink:AnatomicalEntity	body of ilium	The body of ilium enters into the formation of the acetabulum, of which it forms rather less than two-fifths. Its external surface is partly articular, partly non-articular; the articular segment forms part of the lunate surface of the acetabulum, the non-articular portion contributes to the acetabular fossa. The internal surface of the body is part of the wall of the lesser pelvis and gives origin to some fibers of the Obturator internus. Below, it is continuous with the pelvic surfaces of the ischium and pubis, only a faint line indicating the place of union.	FMA:42825	hp.json	ilium body|corpus ossis ilii	http://purl.obolibrary.org/obo/UBERON_0010747		pheno_slim
UBERON:0007106	biolink:AnatomicalEntity	chorionic villus	One of the minute vascular projections of the fetal chorion that combines with maternal uterine tissue to form the placenta.	Wikipedia:Chorionic_villi|SCTID:360403003|BTO:0001161|NCIT:C34125|UMLS:C0008508|EHDAA2:0004717|MESH:D002824	hp.json	placental villus|placental villous|chorionic villus|embryonic placenta|chorionic villi|embryonic part of placenta|villous chorion|fetal placenta|chorionic villous|villous of placenta|fetal part of placenta|placental villi	http://purl.obolibrary.org/obo/UBERON_0007106		
HP:0000719	biolink:PhenotypicFeature	Inappropriate behavior		UMLS:C0233522|SNOMEDCT_US:112082005	hp.json	Inappropriate behavior|Inappropriate behaviour	http://purl.obolibrary.org/obo/HP_0000719		
CHEBI:27314	biolink:ChemicalSubstance	water-soluble vitamin (role)	Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine.		hp.json	wasserloesliche Vitamine|water-soluble vitamin|water-soluble vitamins	http://purl.obolibrary.org/obo/CHEBI_27314		3_STAR
HP:0012700	biolink:PhenotypicFeature	Abnormal large intestine physiology	A functional anomaly of the large intestine.	UMLS:C4022766	hp.json		http://purl.obolibrary.org/obo/HP_0012700		
HP:0000712	biolink:PhenotypicFeature	Emotional lability	Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or out of proportion to events and circumstances.	UMLS:C0085633|SNOMEDCT_US:18963009	hp.json	Mood alterations|Mood lability|Mood swings|Emotional instability|Mood changes	http://purl.obolibrary.org/obo/HP_0000712		
UBERON:0007172	biolink:AnatomicalEntity	angle of scapula		FMA:23800|EMAPA:25125	hp.json	scapular angle	http://purl.obolibrary.org/obo/UBERON_0007172		
HP:0000711	biolink:PhenotypicFeature	Restlessness	A state of unease characterized by diffuse motor activity or motion subject to limited control, nonproductive or disorganized behavior, and subjective distress.	SNOMEDCT_US:162221009|UMLS:C3887611	hp.json	Restlessness	http://purl.obolibrary.org/obo/HP_0000711		
UBERON:0007171	biolink:AnatomicalEntity	border of scapula		FMA:23797|EMAPA:25124	hp.json	scapular border	http://purl.obolibrary.org/obo/UBERON_0007171		
CHEBI:27311	biolink:ChemicalSubstance	volatile oil component	Any plant metabolite that is found naturally as a component of a volatile oil.	Wikipedia:Essential_oil	hp.json	essential oil component|ethereal oil components|ethereal oil component|volatile oil components|essential oil components	http://purl.obolibrary.org/obo/CHEBI_27311		3_STAR
HP:0000713	biolink:PhenotypicFeature	Agitation	A state of exceeding restlessness and excessive motor activity associated with mental distress or a feeling of inner tension.	UMLS:C0085631|SNOMEDCT_US:24199005	hp.json		http://purl.obolibrary.org/obo/HP_0000713		
HP:0000716	biolink:PhenotypicFeature	Depression	Frequent feelings of being down, miserable, and/or hopeless; difficulty recovering from such moods; pessimism about the future; pervasive shame; feeling of inferior self-worth; thoughts of suicide and suicidal behavior.	SNOMEDCT_US:35489007|SNOMEDCT_US:21061000119107|SNOMEDCT_US:78667006|UMLS:C0011581|MSH:D003866	hp.json	Depression|Depressive disorder|Depressivity	http://purl.obolibrary.org/obo/HP_0000716		
GO:1904115	biolink:CellularComponent	axon cytoplasm	Any cytoplasm that is part of a axon.		hp.json	axoplasm	http://purl.obolibrary.org/obo/GO_1904115		
HP:0000718	biolink:PhenotypicFeature	Aggressive behavior	Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself.	MSH:D000374|UMLS:C0424323|UMLS:C1457883|UMLS:C0001807|SNOMEDCT_US:248004009|SNOMEDCT_US:61372001	hp.json	physical aggression|Aggression|Aggressive behaviour|Aggressive behavior|Aggressiveness	http://purl.obolibrary.org/obo/HP_0000718		
UBERON:0034710	biolink:AnatomicalEntity	spinal cord ventricular layer		EMAPA:17585|EHDAA2:0001267	hp.json	spinal cord lateral wall ventricular layer	http://purl.obolibrary.org/obo/UBERON_0034710		
HP:0000717	biolink:PhenotypicFeature	Autism	Autism is a neurodevelopmental disorder characterized by impaired social interaction and communication, and by restricted and repetitive behavior. Autism begins in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual (DSM-IV).	UMLS:C0004352|SNOMEDCT_US:408857007|SNOMEDCT_US:408856003|SNOMEDCT_US:43614003|MSH:D001321	hp.json	Autism	http://purl.obolibrary.org/obo/HP_0000717		
HP:0012709	biolink:PhenotypicFeature	Abnormal brain choline/creatine ratio by MRS	A deviation from normal in the ratio of choline to creatine in the brain identified by magnetic resonance spectroscopy (MRS).	UMLS:C4022760	hp.json		http://purl.obolibrary.org/obo/HP_0012709		
UBERON:0007177	biolink:AnatomicalEntity	lamina propria of mucosa of colon	A lamina propria that is part of a colonic mucosa.	EMAPA:27395|MA:0003196|FMA:15657|SCTID:113284008	hp.json	colonic lamina propria|lamina propria of colonic mucosa|lamina propria mucosae of colon|lamina propria of colonic mucous membrane	http://purl.obolibrary.org/obo/UBERON_0007177		human_reference_atlas
UBERON:0007175	biolink:AnatomicalEntity	inferior angle of scapula	An angle of the scapula formed by the union of the vertebral and axillary borders; its dorsal surface affords attachment to the Teres major and frequently to a few fibers of the Latissimus dorsi.[WP,unvetted].	FMA:13315|EMAPA:25128	hp.json	angulus inferior (scapula)|angulus inferior scapulae	http://purl.obolibrary.org/obo/UBERON_0007175		
UBERON:0034705	biolink:AnatomicalEntity	developing neuroepithelium	An embryonic or larval epithelium that is committed to form part of the nervous system.	BTO:0000314|AEO:0001008|EHDAA2_RETIRED:0004654|FMA:64807	hp.json	neuroepithelium|neurepithelium|embryonic neuroepithelium|embryonic neuroepithelium	http://purl.obolibrary.org/obo/UBERON_0034705		
UBERON:0007174	biolink:AnatomicalEntity	medial border of scapula	The medial border of the scapula (vertebral border, medial margin) is the longest of the three borders, and extends from the medial to the inferior angle. It is arched, intermediate in thickness between the superior and the axillary borders, and the portion of it above the spine forms an obtuse angle with the part below. This border presents an anterior and a posterior lip, and an intermediate narrow area. The anterior lip affords attachment to the Serratus anterior; the posterior lip, to the Supraspinatus above the spine, the Infraspinatus below; the area between the two lips, to the Levator scapulC& above the triangular surface at the commencement of the spine, to the Rhomboideus minor on the edge of that surface, and to the Rhomboideus major below it; this last is attached by means of a fibrous arch, connected above to the lower part of the triangular surface at the base of the spine, and below to the lower part of the border.	FMA:23242|EMAPA:25127	hp.json	vertebral border of the scapula|medial part of scapula|medial border of the scapula|medial margin of the scapula|vertebral border of scapula|vertebral border|margo medialis scapulae|margo medialis (scapula)	http://purl.obolibrary.org/obo/UBERON_0007174		
HP:0000710	biolink:PhenotypicFeature	Hyperorality	A tendency or compulsion to examine objects by mouth.	UMLS:C1838320	hp.json	Hyperoralia	http://purl.obolibrary.org/obo/HP_0000710		
UBERON:0034706	biolink:AnatomicalEntity	proliferating neuroepithelium	An epithelium that is undergoing proliferation to provide large numbers of neuronal cells.	AEO:0001009	hp.json		http://purl.obolibrary.org/obo/UBERON_0034706		
UBERON:0007173	biolink:AnatomicalEntity	lateral border of scapula	The lateral border (or axillary border, or margin) is the thickest of the three borders of the scapula. It begins above at the lower margin of the glenoid cavity, and inclines obliquely downward and backward to the inferior angle. Immediately below the glenoid cavity is a rough impression, the infraglenoid tuberosity, about 2.5 cm. in length, which gives origin to the long head of the Triceps brachii; in front of this is a longitudinal groove, which extends as far as the lower third of this border, and affords origin to part of the Subscapularis. The inferior third is thin and sharp, and serves for the attachment of a few fibers of the Teres major behind, and of the Subscapularis in front.	FMA:23239|EMAPA:25126	hp.json	lateral part of scapula|margo lateralis (scapula)|lateral border of scapula|axillary border of scapula|margo lateralis scapulae	http://purl.obolibrary.org/obo/UBERON_0007173		
UBERON:0034707	biolink:AnatomicalEntity	differentiating neuroepithelium	A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells.	AEO:0001010	hp.json		http://purl.obolibrary.org/obo/UBERON_0034707		
HP:0012701	biolink:PhenotypicFeature	Bowel urgency	A sudden, irresistible need to have a bowel movement.	UMLS:C0426636|SNOMEDCT_US:71820002	hp.json	Fecal urgency|Faecal urgency	http://purl.obolibrary.org/obo/HP_0012701		
UBERON:0034708	biolink:AnatomicalEntity	cerebellum marginal layer		DHBA:12695|EHDAA2:0001152|EMAPA:17789	hp.json	MZCB|marginal zone of cerebellum	http://purl.obolibrary.org/obo/UBERON_0034708		
HP:0012702	biolink:PhenotypicFeature	Tenesmus	A repeated, painful urge to defecate without excreting stool.	UMLS:C0232726|SNOMEDCT_US:267053000|SNOMEDCT_US:6548007	hp.json		http://purl.obolibrary.org/obo/HP_0012702		
UBERON:0034709	biolink:AnatomicalEntity	hindbrain marginal layer		DHBA:12694|EMAPA:32916	hp.json	marginal zone of hindbrain|MZH	http://purl.obolibrary.org/obo/UBERON_0034709		
HP:0012703	biolink:PhenotypicFeature	Abnormal subarachnoid space morphology	Abnormality in the space in the meninges beneath the arachnoid membrane and above the pia mater that contains the cerebrospinal fluid.	UMLS:C4022765	hp.json	Abnormality of the subarachnoid space	http://purl.obolibrary.org/obo/HP_0012703		
HP:0012704	biolink:PhenotypicFeature	Widened subarachnoid space	An increase in size of the anatomic space between the arachnoid membrane and pia mater.	UMLS:C1846151	hp.json	Enlarged subarachnoid space|Widened subarachnoid spaces	http://purl.obolibrary.org/obo/HP_0012704		
HP:0012705	biolink:PhenotypicFeature	Abnormal metabolic brain imaging by MRS	An anomaly of metabolism in the brain identified by magnetic resonance spectroscopy (MRS).	UMLS:C4022764	hp.json		http://purl.obolibrary.org/obo/HP_0012705		
HP:0012706	biolink:PhenotypicFeature	Elevated brain choline level by MRS	An increase in the level of choline-containing compounds in the brain identified by magnetic resonance spectroscopy (MRS).	UMLS:C4022763	hp.json		http://purl.obolibrary.org/obo/HP_0012706		
HP:0012707	biolink:PhenotypicFeature	Elevated brain lactate level by MRS	An increase in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS).	UMLS:C4022762	hp.json		http://purl.obolibrary.org/obo/HP_0012707		
HP:0012708	biolink:PhenotypicFeature	Reduced brain N-acetyl aspartate level by MRS	A decrease in the level of N-acetyl aspartate in the brain identified by magnetic resonance spectroscopy (MRS).	UMLS:C4022761	hp.json	Reduced brain N-acetyl aspartate level by magnetic resonance spectroscopy	http://purl.obolibrary.org/obo/HP_0012708		
CHEBI:29987	biolink:ChemicalSubstance	glutamate(2-)	A dicarboxylic acid dianion that is the conjugate base of glutamate(1-).	Gmelin:327903|Beilstein:4134100|Reaxys:4134100	hp.json	glutamic acid dianion|glutamate|2-aminopentanedioate|glutamate(2-)	http://purl.obolibrary.org/obo/CHEBI_29987		3_STAR
UBERON:0019143	biolink:AnatomicalEntity	intramuscular adipose tissue	Adipose tissue which is located throughout skeletal muscle and is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat is associated with insulin resistance and type 2 diabetes.	BTO:0004043	hp.json	intramuscular fat	http://purl.obolibrary.org/obo/UBERON_0019143		
CHEBI:29986	biolink:ChemicalSubstance	D-glutamate(1-)	An alpha-amino-acid anion that is the conjugate base of D-glutamic acid, having anionic carboxy groups and a cationic amino group	Beilstein:8319427|MetaCyc:D-GLT	hp.json	hydrogen D-glutamate|D-glutamate|(2R)-2-ammoniopentanedioate|D-glutamate(1-)|D-glutamic acid monoanion	http://purl.obolibrary.org/obo/CHEBI_29986		3_STAR
CHEBI:27325	biolink:ChemicalSubstance	xanthophyll			hp.json		http://purl.obolibrary.org/obo/CHEBI_27325		
CHEBI:29989	biolink:ChemicalSubstance	D-glutamate(2-)		Beilstein:8143000|Gmelin:327904	hp.json	D-glutamate|D-glutamate(2-)|D-glutamic acid dianion|(2R)-2-aminopentanedioate	http://purl.obolibrary.org/obo/CHEBI_29989		3_STAR
CHEBI:29988	biolink:ChemicalSubstance	L-glutamate(2-)	An L-alpha-amino acid anion that is the dianion obtained by the deprotonation of the both the carboxy groups of L-glutamic acid.	Gmelin:327905	hp.json	L-glutamic acid dianion|L-glutamate|(2S)-2-aminopentanedioate|L-glutamate(2-)	http://purl.obolibrary.org/obo/CHEBI_29988		3_STAR
HP:0000723	biolink:PhenotypicFeature	Restrictive behavior	Behavior characterized by an abnormal limitation to few interests and activities.	UMLS:C4021799|UMLS:C2675334	hp.json	Restricted behaviour|Restrictive behaviour|Restricted behavior|Restrictive behavior, interests, and activities	http://purl.obolibrary.org/obo/HP_0000723		
HP:0000722	biolink:PhenotypicFeature	Obsessive-compulsive behavior	Recurrent obsessions or compulsions that are severe enough to be time consuming (i.e., they take more than 1 hour a day) or cause marked distress or significant impairment (DSM-IV).	SNOMEDCT_US:12479006|UMLS:C0600104|MSH:D009771|MSH:D003192|SNOMEDCT_US:191736004|UMLS:C0028768	hp.json	Obsessive compulsive disorder|Obsessive compulsive behaviour|OCD|Obsessive-compulsive behavior|Obsessive-compulsive behaviour|Obsessive compulsive behavior|Obsessive-compulsive disorder	http://purl.obolibrary.org/obo/HP_0000722		
PR:P16872	biolink:Protein	interleukin-7 receptor subunit alpha (mouse)	An interleukin-7 receptor subunit alpha that is encoded in the genome of mouse.	UniProtKB:P16872	hp.json	mIL7R|IL-7R subunit alpha (mouse)|IL-7R-alpha (mouse)|CD127 (mouse)|Il7r|IL-7 receptor subunit alpha (mouse)|IL-7RA (mouse)	http://purl.obolibrary.org/obo/PR_P16872		
UBERON:0007160	biolink:AnatomicalEntity	inferior petrosal sinus	The inferior petrosal sinus, within the human head, is an area beneath the brain, which allows blood veins to span the area, from the center of the head downward. It drains from the cavernous sinus (beneath the brain) to the sigmoid sinuses above the internal jugular vein.	EMAPA:19234|FMA:50770	hp.json	sinus petrosal inferior	http://purl.obolibrary.org/obo/UBERON_0007160		human_reference_atlas
CHEBI:29985	biolink:ChemicalSubstance	L-glutamate(1-)	An alpha-amino-acid anion that is the conjugate base of L-glutamic acid, having anionic carboxy groups and a cationic amino group	Gmelin:936654|CAS:11070-68-1|MetaCyc:GLT	hp.json	(2S)-2-ammoniopentanedioate|hydrogen L-glutamate|L-glutamate|L-glutamate|L-glutamate(1-)|L-glutamic acid, ion(1-)|L-glutamic acid monoanion	http://purl.obolibrary.org/obo/CHEBI_29985		3_STAR
HP:0000725	biolink:PhenotypicFeature	Psychotic episodes		UMLS:C0338614	hp.json	Psychotic episodes	http://purl.obolibrary.org/obo/HP_0000725		
HP:0000727	biolink:PhenotypicFeature	Frontal lobe dementia		SNOMEDCT_US:278857002|UMLS:C0338455	hp.json		http://purl.obolibrary.org/obo/HP_0000727		
HP:0000726	biolink:PhenotypicFeature	Dementia	A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior.	MSH:D003704|SNOMEDCT_US:52448006|UMLS:C0497327	hp.json	Dementia, progressive|Progressive dementia|Dementia	http://purl.obolibrary.org/obo/HP_0000726		
HP:0000729	biolink:PhenotypicFeature	Autistic behavior	Persistent deficits in social interaction and communication and interaction as well as a markedly restricted repertoire of activity and interest as well as repetitive patterns of behavior.	MSH:D000067877|UMLS:C1510586|UMLS:C0856975	hp.json	Pervasive developmental disorder|ASD|Autism spectrum disorder|Autistic behaviour|Autistic behaviors|Autistic behaviours|Autism spectrum disorders	http://purl.obolibrary.org/obo/HP_0000729		
UBERON:0034720	biolink:AnatomicalEntity	head taste bud	A taste bud that is located on the skin of the head.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034720		
UBERON:0034721	biolink:AnatomicalEntity	pharyngeal taste bud	A taste bud that is located in the pharynx.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034721		
HP:0000728	biolink:PhenotypicFeature	Impaired ability to form peer relationships		UMLS:C1837649	hp.json		http://purl.obolibrary.org/obo/HP_0000728		
UBERON:0034711	biolink:AnatomicalEntity	cortical preplate	The layer of the developing cerebral cortex that is formed from the first cohort of neurons to migrate out of the cortical ventricular zone; split by the second wave into marginal zone and subplate.	EMAPA:35261	hp.json		http://purl.obolibrary.org/obo/UBERON_0034711		
UBERON:0034713	biolink:AnatomicalEntity	cranial neuron projection bundle	Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain.		hp.json	neuron projection bundle from brain|cranial nerve or tract|cranial nerve or tract|cranial nerve fiber bundle|cranial nerve fiber bundle|cranial nerve fiber tract|cranial nerve fiber tract|neuron projection bundle from brain	http://purl.obolibrary.org/obo/UBERON_0034713		
CHEBI:15318	biolink:ChemicalSubstance	xanthine	A purine nucleobase found in humans and other organisms.	YMDB:YMDB00263|PMID:24629268|PMID:9007687|PMID:1557408|ECMDB:ECMDB00292|KNApSAcK:C00019660	hp.json	2,6-dioxopurine|2,6-dioxopurines|xanthines|xanthine	http://purl.obolibrary.org/obo/CHEBI_15318		3_STAR
UBERON:0034714	biolink:AnatomicalEntity	epiphyseal tract	A cranial nerve fiber tract that innervates the parietal eye.		hp.json	epiphyseal nerve	http://purl.obolibrary.org/obo/UBERON_0034714		
UBERON:0034715	biolink:AnatomicalEntity	pineal tract	A cranial nerve fiber tract that innervates the pineal body.	FMA:77600	hp.json	pineal nerve	http://purl.obolibrary.org/obo/UBERON_0034715		
UBERON:0034717	biolink:AnatomicalEntity	integumental taste bud	A taste bud that is located external to the digestive tube, on the head or body, as found in species such as goldfish.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034717		
HP:0000721	biolink:PhenotypicFeature	Lack of spontaneous play		UMLS:C1837650	hp.json	Lack of spontaneous play	http://purl.obolibrary.org/obo/HP_0000721		
HP:0000720	biolink:PhenotypicFeature	obsolete Mood swings			hp.json		http://purl.obolibrary.org/obo/HP_0000720		
UBERON:0034719	biolink:AnatomicalEntity	lip taste bud	A taste bud that is located on a lip.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034719		
UBERON:0034730	biolink:AnatomicalEntity	olfactory tract linking bulb to ipsilateral dorsal telencephalon		ZFA:0000229|TAO:0000229	hp.json	lateral olfactory tract|tractus olfactorius lateralis	http://purl.obolibrary.org/obo/UBERON_0034730		
GO:1904145	biolink:BiologicalProcess	negative regulation of meiotic cell cycle process involved in oocyte maturation	Any process that stops, prevents or reduces the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.		hp.json	downregulation of meiotic cell cycle process involved in oocyte maturation|down regulation of meiotic cell cycle process involved in oocyte maturation|inhibition of meiotic cell cycle process involved in oocyte maturation|down-regulation of meiotic cell cycle process involved in oocyte maturation	http://purl.obolibrary.org/obo/GO_1904145		
UBERON:0034722	biolink:AnatomicalEntity	mouth roof taste bud	A taste bud that is located on the roof of the mouth.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034722		
UBERON:0007158	biolink:AnatomicalEntity	lumen of anal canal	An anatomical cavity that surrounded_by a anal canal.	EMAPA:18836|FMA:17357	hp.json	anal canal lumen	http://purl.obolibrary.org/obo/UBERON_0007158		
UBERON:0007156	biolink:AnatomicalEntity	inferior thyroid vein	The inferior thyroid veins two, frequently three or four, in number, arise in the venous plexus on the thyroid gland, communicating with the middle and superior thyroid veins. They form a plexus in front of the trachea, behind the Sternothyreoidei. From this plexus, a left vein descends and joins the left innominate trunk, and a right vein passes obliquely downward and to the right across the innominate artery to open into the right innominate vein, just at its junction with the superior vena cava; sometimes the right and left veins open by a common trunk in the latter situation. These veins receive esophageal tracheal, and inferior laryngeal veins, and are provided with valves at their terminations in the innominate veins.	EMAPA:18763|FMA:4728	hp.json	vena thyroidea inferioris|inferior thyroid venous tree	http://purl.obolibrary.org/obo/UBERON_0007156		human_reference_atlas
UBERON:0034724	biolink:AnatomicalEntity	esophageal taste bud	A taste bud that is located in the esophagus.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034724		
UBERON:0034726	biolink:AnatomicalEntity	trunk taste bud	A taste bud that is located on the skin of the trunk.		hp.json		http://purl.obolibrary.org/obo/UBERON_0034726		
UBERON:0034728	biolink:AnatomicalEntity	autonomic nerve	The autonomic nerve is a small nerve which carries postganglionic sympathetic and parasympathetic neurons from the zygomaticotemporal nerve; a branch of the maxillary nerve, to the lacrimal nerve; a branch of the ophthalmic nerve. These neurons derive from the superior cervical ganglion and the pterygopalatine ganglion respectively. They will travel to the lacrimal gland via the lacrimal nerve. Parasympathetic will induce lacrimation and vice versa.	MESH:D017776|SCTID:276145003|FMA:5866|Wikipedia:Autonomic_nerve|EMAPA:37957	hp.json	nervus visceralis|visceral nerve	http://purl.obolibrary.org/obo/UBERON_0034728		
UBERON:0007151	biolink:AnatomicalEntity	mitral valve leaflet	A valve leafleft that is part of a mitral valve.	FMA:7241|VHOG:0000822|EMAPA:18628	hp.json	mitral valvular leaflet|mitral valve leaflet|leaflet of mitral valve|mitral valve leaflets	http://purl.obolibrary.org/obo/UBERON_0007151		pheno_slim
UBERON:0034729	biolink:AnatomicalEntity	sympathetic nerve		SCTID:181098007|EMAPA:37958	hp.json		http://purl.obolibrary.org/obo/UBERON_0034729		human_reference_atlas
UBERON:0007159	biolink:AnatomicalEntity	lumen of colon	An anatomical cavity that surrounded_by a colon.	SCTID:362156004|EMAPA:18945|FMA:18374	hp.json	colon lumen|colonic lumen	http://purl.obolibrary.org/obo/UBERON_0007159		
HP:0000709	biolink:PhenotypicFeature	Psychosis	A condition characterized by changes of personality and thought patterns often accompanied by hallucinations and delusional beliefs.	UMLS:C0033975|MSH:D011618|SNOMEDCT_US:69322001	hp.json	Psychosis	http://purl.obolibrary.org/obo/HP_0000709		
HP:0000708	biolink:PhenotypicFeature	Behavioral abnormality	An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities.	UMLS:C0233514|UMLS:C0004941|SNOMEDCT_US:25786006|MSH:D000066553|SNOMEDCT_US:277843001|MSH:D001526	hp.json	Psychiatric disturbances|Behavioural/Psychiatric abnormality|Behavioural abnormality|Behavioral symptoms|Behavioural disturbances|Behavioural symptoms|Behavioral disturbances|Behavioural problems|Behavioral problems|Behavioural changes|Behavioural disorders|Behavioral abnormality|Behavioral disorders|Behavioral changes|Psychiatric disorders|Behavioral/psychiatric abnormalities	http://purl.obolibrary.org/obo/HP_0000708		
HP:0000700	biolink:PhenotypicFeature	Periapical bone loss	Radiolucency (reflecting a reduction in the bony substance) around the apex (the tip of the dental root).	UMLS:C0034543|UMLS:C1852169|SNOMEDCT_US:81407003|MSH:D011842|UMLS:C4280609|UMLS:C0031029|SNOMEDCT_US:89988002|MSH:D010484	hp.json	Periapical cyst|Periapical radiolucency|Periapical granuloma|Periapical lesion|Periapical radiolucencies|Dark spot around tooth root on x-ray|Bone loss around tooth root	http://purl.obolibrary.org/obo/HP_0000700		
HP:0000703	biolink:PhenotypicFeature	Dentinogenesis imperfecta	Developmental dysplasia of dentin.	MSH:D003811|UMLS:C0011436|SNOMEDCT_US:196286005	hp.json		http://purl.obolibrary.org/obo/HP_0000703		hposlim_core
CHEBI:27300	biolink:ChemicalSubstance	vitamin D	Any member of a group of fat-soluble hydroxy seco-steroids that exhibit biological activity against vitamin D deficiency. Vitamin D  can be obtained from sun exposure, food and supplements and is biologically inactive and converted into the biologically active calcitriol via double hydroxylation in the body.	MetaCyc:Vitamin-D|Wikipedia:Vitamin_D	hp.json	D vitamins|vitamin Ds|vitamins D|vitamin D vitamers|vitamin D vitamer	http://purl.obolibrary.org/obo/CHEBI_27300		3_STAR
HP:0000705	biolink:PhenotypicFeature	Amelogenesis imperfecta	A developmental dysplasia of the dental enamel.	SNOMEDCT_US:78494001|UMLS:C0002452|MSH:D000567	hp.json		http://purl.obolibrary.org/obo/HP_0000705		hposlim_core
HP:0000704	biolink:PhenotypicFeature	Periodontitis	Inflammation of the periodontium.	UMLS:C0031099|MSH:D005882|MSH:D010518|SNOMEDCT_US:41565005|UMLS:C0017563|SNOMEDCT_US:18718003|UMLS:C0031090|MSH:D010510|SNOMEDCT_US:2556008	hp.json	Pyorrhea|Gum disease|Periodontal disease	http://purl.obolibrary.org/obo/HP_0000704		hposlim_core
HP:0000707	biolink:PhenotypicFeature	Abnormality of the nervous system	An abnormality of the nervous system.	UMLS:C0497552|MSH:D009421|SNOMEDCT_US:88425004	hp.json	Neurologic abnormalities|Neurological abnormality|Brain and/or spinal cord issue|Abnormality of the nervous system	http://purl.obolibrary.org/obo/HP_0000707		
GO:1904146	biolink:BiologicalProcess	positive regulation of meiotic cell cycle process involved in oocyte maturation	Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.		hp.json	up regulation of meiotic cell cycle process involved in oocyte maturation|up-regulation of meiotic cell cycle process involved in oocyte maturation|activation of meiotic cell cycle process involved in oocyte maturation|upregulation of meiotic cell cycle process involved in oocyte maturation	http://purl.obolibrary.org/obo/GO_1904146		
HP:0000706	biolink:PhenotypicFeature	Eruption failure	A tooth which does not erupt within the teeth eruption timeline and after the loss of eruption potential.	SNOMEDCT_US:109542004|UMLS:C1290587	hp.json	Pseudoanodontia|Pseudo-anodontia|Failure of eruption of tooth|Unerupted dentition|Unerupted tooth	http://purl.obolibrary.org/obo/HP_0000706		
UBERON:0007147	biolink:AnatomicalEntity	lumen of midgut	An anatomical cavity that surrounded_by a midgut.	FMA:54366|EMAPA:18377	hp.json	midgut lumen	http://purl.obolibrary.org/obo/UBERON_0007147		
CHEBI:15339	biolink:ChemicalSubstance	acceptor	A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity.	KEGG:C00028|KEGG:C16722	hp.json	Hydrogen-acceptor|Akzeptor|accepteur|A|Acceptor|Oxidized donor	http://purl.obolibrary.org/obo/CHEBI_15339		3_STAR
UBERON:0007144	biolink:AnatomicalEntity	embryonic post-anal tail	An embryonic structure that will either develop into a post-anal tail or recede into a vestigial remnant of the tail.	EMAPA:16748|FMA:85540	hp.json	tail of embryo|embryo tail|embryonic tail	http://purl.obolibrary.org/obo/UBERON_0007144		
UBERON:0034736	biolink:AnatomicalEntity	coracoclavicular ligament	Any ligament that connects the coracoid process with the clavicle.	FMA:26029	hp.json	accessory ligament of acromioclavicular joint	http://purl.obolibrary.org/obo/UBERON_0034736		
UBERON:0007143	biolink:AnatomicalEntity	right internal carotid artery	An internal carotid artery that branching_part_of a right common carotid artery plus branches.	SCTID:161251001|FMA:3949|EMAPA:16330	hp.json	arteria carotis interna dextra	http://purl.obolibrary.org/obo/UBERON_0007143		
UBERON:0007142	biolink:AnatomicalEntity	left internal carotid artery	An internal carotid artery that branching_part_of a left common carotid artery plus branches.	EMAPA:16329|FMA:4062|SCTID:161452006	hp.json	arteria caritis interna sinistra	http://purl.obolibrary.org/obo/UBERON_0007142		
CHEBI:17996	biolink:ChemicalSubstance	chloride	A halide anion formed when chlorine picks up an electron to form an an anion.	Beilstein:3587171|PDBeChem:CL|CAS:16887-00-6|Gmelin:14910|CAS:16887-00-6|UM-BBD_compID:c0884|CAS:16887-00-6|KEGG:C00115|KEGG:C00698	hp.json	Cl(-)|Chloride|CHLORIDE ION|Cl-|Chloride(1-)|Chlorine anion|chloride(1-)|chloride|chloride|Chloride ion	http://purl.obolibrary.org/obo/CHEBI_17996		3_STAR
UBERON:0007148	biolink:AnatomicalEntity	lumen of hindgut	An anatomical cavity that surrounded_by a hindgut.	FMA:54367|EMAPA:18396	hp.json	hindgut lumen	http://purl.obolibrary.org/obo/UBERON_0007148		
HP:0034096	biolink:PhenotypicFeature	Anti-phosphatidic acid antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidic acid.		hp.json		http://purl.obolibrary.org/obo/HP_0034096		
HP:0034095	biolink:PhenotypicFeature	Anti-endothelin-1 type A receptor antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against endothelin-1 type A receptor.		hp.json	Anti-ETAR antibody positivity	http://purl.obolibrary.org/obo/HP_0034095		
HP:0034098	biolink:PhenotypicFeature	Anti-phosphatidyl glycerol antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl glycerol.		hp.json		http://purl.obolibrary.org/obo/HP_0034098		
HP:0034097	biolink:PhenotypicFeature	Anti-phosphatidyl choline antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl choline.		hp.json		http://purl.obolibrary.org/obo/HP_0034097		
HP:0034092	biolink:PhenotypicFeature	Anti-cyclic citrullinated peptide antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against cyclic citrullinated peptide.		hp.json	Anti-CCP antibody positivity	http://purl.obolibrary.org/obo/HP_0034092		
HP:0034091	biolink:PhenotypicFeature	Anti-platelet derived growth factor receptor	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against platelet derived growth factor receptor.		hp.json	Anti-PDGFR antibody positivity	http://purl.obolibrary.org/obo/HP_0034091		
HP:0034094	biolink:PhenotypicFeature	Anti-angiotensin receptor type-1 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against angiotensin receptor type-1.		hp.json	Anti-AT1R antibody positivity	http://purl.obolibrary.org/obo/HP_0034094		
HP:0034093	biolink:PhenotypicFeature	Anti-Ro52/TRIM21 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ro52/TRIM21.		hp.json	Anti-Ro52 antibody positivity	http://purl.obolibrary.org/obo/HP_0034093		
HP:0034099	biolink:PhenotypicFeature	Anti-phosphatidyl inositol antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl inositol.		hp.json		http://purl.obolibrary.org/obo/HP_0034099		
CL:0000488	biolink:Cell	visible light photoreceptor cell	A photoreceptor cell that detects visible light.		hp.json		http://purl.obolibrary.org/obo/CL_0000488		
CL:0000498	biolink:Cell	inhibitory interneuron	An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS).	FMA:84776	hp.json		http://purl.obolibrary.org/obo/CL_0000498		
UBERON:0010801	biolink:AnatomicalEntity	calcaneum pre-cartilage condensation	A calcaneum endochondral element that is composed primarily of a pre-cartilage condensation.	EMAPA:17736	hp.json	calcaneous pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010801		
CL:0000499	biolink:Cell	stromal cell	A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.	BTO:0002064|FMA:83624	hp.json		http://purl.obolibrary.org/obo/CL_0000499		
CL:0000492	biolink:Cell	CD4-positive helper T cell	A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions.	CALOHA:TS-1146|FMA:70572	hp.json	CD4-positive helper T-cell|CD4-positive helper T lymphocyte|CD4-positive T-helper cell|CD4-positive helper T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000492		
CL:0000467	biolink:Cell	adrenocorticotropic hormone secreting cell	A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin.		hp.json	ACTH secreting cell|adrenocorticotrophic hormone secreting cell|corticotropin secreting cell|corticotrophin hormone secreting cell|corticotropin hormone secreting cell	http://purl.obolibrary.org/obo/CL_0000467		
CHEBI:52254	biolink:ChemicalSubstance	apatite			hp.json		http://purl.obolibrary.org/obo/CHEBI_52254		
CHEBI:52255	biolink:ChemicalSubstance	hydroxylapatite			hp.json		http://purl.obolibrary.org/obo/CHEBI_52255		
HP:0010096	biolink:PhenotypicFeature	Complete duplication of the distal phalanx of the hallux		UMLS:C4024051	hp.json	Complete duplication of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010096		
HP:0010095	biolink:PhenotypicFeature	Partial duplication of the proximal phalanx of the hallux	Partial duplication of the proximal phalanx of big toe.	UMLS:C4024052	hp.json	Partial duplication of the innermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010095		
HP:0010094	biolink:PhenotypicFeature	Complete duplication of the proximal phalanx of the hallux	Complete duplication of the proximal phalanx of big toe.	UMLS:C4024053	hp.json	Complete duplication of the innermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010094		
HP:0010093	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the hallux	Partial or complete duplication of the proximal phalanx of big toe.	UMLS:C4024054	hp.json	Duplication of the innermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010093		
HP:0010092	biolink:PhenotypicFeature	Triangular shaped proximal phalanx of the hallux		UMLS:C4024055	hp.json	Triangular shaped innermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010092		
HP:0010091	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanx of the hallux		UMLS:C4024056	hp.json	Fused innermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010091		
HP:0010090	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the hallux		UMLS:C4024057	hp.json	Uneven increase in bone density in the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010090		
HP:0010099	biolink:PhenotypicFeature	Partial duplication of the 1st metatarsal	A developmental defect consisting in the duplication of part of the first metatarsal bone.	UMLS:C4024049	hp.json	Partial duplication of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010099		
HP:0010098	biolink:PhenotypicFeature	Complete duplication of the 1st metatarsal	A developmental defect consisting in the complete duplication of the first metatarsal bone.	UMLS:C4024050	hp.json	Complete duplication of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010098		
HP:0010097	biolink:PhenotypicFeature	Partial duplication of the distal phalanx of the hallux		UMLS:C4021337	hp.json	Partial duplication of the outermost bone of big toe|Notched outermost bone of big toe|Bifid distal phalanx of hallux	http://purl.obolibrary.org/obo/HP_0010097		
CL:0000473	biolink:Cell	defensive cell	A cell whose primary function is to protect the organism.		hp.json		http://purl.obolibrary.org/obo/CL_0000473		
HP:0034052	biolink:PhenotypicFeature	Impaired toe-walking ability	Difficulty or reduced ability to walk on toes. Toe-walking can be tested as a part of the neurological examination. Foot plantar flexion weakness leads to difficulties in walking on toes.		hp.json		http://purl.obolibrary.org/obo/HP_0034052		
HP:0034051	biolink:PhenotypicFeature	Hypoplastic anterior limbs of the internal capsule	Underdevelopment of the frontal part (anterior crus or anterior limb) of the internal capsule.		hp.json		http://purl.obolibrary.org/obo/HP_0034051		
HP:0034054	biolink:PhenotypicFeature	Probst bundles	Probst bundles (also known as longitudinal callosal fascicles) are neuroanatomical homologues to the corpus callosum and can occur in association with callosal agenesis. Probst bundles are white matter fibers that normally cross the corpus callosum but (because of the agenesis of the corpus callosum) fail to cross the midline, such that when they reach the corticoseptal boundary, they turn and run parallel to the interhemispheric fissure within the septal leaves, indenting the medial walls of the lateral ventricles.		hp.json		http://purl.obolibrary.org/obo/HP_0034054		
HP:0034053	biolink:PhenotypicFeature	Decreased acid ceramidase activity			hp.json		http://purl.obolibrary.org/obo/HP_0034053		
HP:0034050	biolink:PhenotypicFeature	Elevated urinary prostaglandin E2 metabolite level	An increased amount of prostaglandin E2 metabolite (PGE-M) in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0034050		
CL:0000446	biolink:Cell	chief cell of parathyroid gland	An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone.	FMA:69078|CALOHA:TS-2140|BTO:0004712	hp.json	principal cell of parathyroid gland|parathyroid chief cell|parathyroid hormone secreting cell|parathyroid gland chief cell	http://purl.obolibrary.org/obo/CL_0000446		
CL:0000447	biolink:Cell	carbohydrate secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000447		
HP:0034059	biolink:PhenotypicFeature	Abnormal fetal physiology	Any functional anomaly of the fetus.		hp.json	Functional fetal anomaly	http://purl.obolibrary.org/obo/HP_0034059		
HP:0034056	biolink:PhenotypicFeature	Increased fecal calprotectin level	An increased amount of calprotectin in the feces.		hp.json		http://purl.obolibrary.org/obo/HP_0034056		
HP:0034055	biolink:PhenotypicFeature	Anti-side-chain cleavage enzyme antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against cytochrome P450 cholesterol side-chain cleavage enzyme (P450scc), which is encoded by CYP11A1 cytochrome P450 family 11 subfamily A member 1 (Gene ID:1583).		hp.json	Anti-P450scc	http://purl.obolibrary.org/obo/HP_0034055		
HP:0034058	biolink:PhenotypicFeature	Abnormal fetal morphology	Any structural anomaly of the fetus.		hp.json	Structural fetal anomaly	http://purl.obolibrary.org/obo/HP_0034058		
HP:0034057	biolink:PhenotypicFeature	Fetal anomaly	Structural or functional abnormalities of the fetus. Note that this section comprises terms that describe abnormalities that are specific to the fetus or differ from the corresponding general terms. A term from anywhere in the Human Phenotype Ontology can be applied to a fetus if appropriate.		hp.json		http://purl.obolibrary.org/obo/HP_0034057		
UBERON:0007213	biolink:AnatomicalEntity	mesenchyme derived from head neural crest	Mesenchyme that develops_from a cranial neural crest.	EHDAA2:0000735|EMAPA:16169|TAO:0000787|EMAPA:16271|EMAPA_RETIRED:16271|EFO:0003572|ZFA:0000787	hp.json	head mesenchyme from cranial neural crest|head mesenchyme from neural crest|head neural crest derived mesenchyme	http://purl.obolibrary.org/obo/UBERON_0007213		vertebrate_core|efo_slim
UBERON:0009877	biolink:AnatomicalEntity	metapodium region	Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region.		hp.json	equine cannon region|metapodium|metacarpus/metatarsus|cannon region|metacarpal or metatarsal part of limb|metapodial segment|metacarpus/metatarsus region	http://purl.obolibrary.org/obo/UBERON_0009877		
CL:0000440	biolink:Cell	melanocyte stimulating hormone secreting cell	A cell of the intermediate pituitary that produces melanocyte stimulating hormone.	BTO:0002277	hp.json	melanotroph|melanotrope	http://purl.obolibrary.org/obo/CL_0000440		
UBERON:0010852	biolink:AnatomicalEntity	fibula pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a fibula.	EHDAA2:0000509|EHDAA:6196	hp.json	fibulal pre-cartilage condensation|fibular pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010852		
UBERON:0009878	biolink:AnatomicalEntity	mesopodial skeleton	The collection of all skeletal elements in a mesopodium. Examples: the tarsal skeleton, the carpal skeleton.	VSAO:0005022	hp.json	mesopodial skeleton|carpal/tarsal skeleton|skeletal parts of mesopodium|basipodium skeleton|basipodium|mesopodium|mesopodium skeleton	http://purl.obolibrary.org/obo/UBERON_0009878		
UBERON:0009879	biolink:AnatomicalEntity	tarsal skeleton	Subdivision of skeleton that consists of endochondral elements distal to the zeugopodial skeletal elements which constitute the proximal region of the posterior autopod skeleton[PHENOSCAPE:ad].	FMA:71339|VSAO:0005024|XAO:0003211|VHOG:0001160|EMAPA:19133|GAID:1223|AAO:0000220|MA:0000050	hp.json	hind mesopodial skeleton|basipodium|mesopodium|tarsus|tarsal bones set|hind mesopodium|tarsalia|skeletal parts of hind mesopodium|set of tarsal bones|hind mesopodium skeleton|tarsal bones	http://purl.obolibrary.org/obo/UBERON_0009879		pheno_slim
CHEBI:76283	biolink:ChemicalSubstance	sebacate(2-)	A dicarboxylic acid dianion obtained by deprotonation of both carboxy groups of suberic acid; major species at pH 7.3.	MetaCyc:CPD-3623|PMID:21886157|Reaxys:3906061	hp.json	C10-DCA(2-)|decanedioate(2-)|decanedioate|sebacate|decanedioate	http://purl.obolibrary.org/obo/CHEBI_76283		3_STAR
CL:0000443	biolink:Cell	calcitonin secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000443		
UBERON:0009870	biolink:AnatomicalEntity	zone of stomach	A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland.	MA:0002561|SCTID:245415005|EMAPA:35821|FMA:14558|Wikipedia:Stomach#Sections	hp.json	region of stomach|section of stomach|gastric zone	http://purl.obolibrary.org/obo/UBERON_0009870		
UBERON:0009871	biolink:AnatomicalEntity	nephrogenic zone	Outer portion of the renal cortex. Site of formation of medullary and cortical elements.	EMAPA:27721|MA:0002996	hp.json	cortical nephrogenic zone|cortical nephrogenic niche|nephrogenic tissue	http://purl.obolibrary.org/obo/UBERON_0009871		pheno_slim
UBERON:0007214	biolink:AnatomicalEntity	mesenchyme derived from trunk neural crest	Mesenchyme that develops_from a trunk neural crest.	EHDAA2:0002093|EMAPA:16182|ZFA:0000999|TAO:0000999	hp.json	trunk neural crest derived mesenchyme|trunk mesenchyme from neural crest	http://purl.obolibrary.org/obo/UBERON_0007214		vertebrate_core
HP:0034063	biolink:PhenotypicFeature	Anti-islet antigen-2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against tyrosine phosphatase IA-2.		hp.json	Anti-IA2A|Anti-IA2 antibody positivity|ICA512	http://purl.obolibrary.org/obo/HP_0034063		
HP:0034062	biolink:PhenotypicFeature	Anti-insulin antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against insulin.		hp.json	Insulin autoantibodies|IAA positivity	http://purl.obolibrary.org/obo/HP_0034062		
HP:0034065	biolink:PhenotypicFeature	Anti-Zinc transporter 8 antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against zinc transporter 8.		hp.json	Anti ZnT8 autoantibodies	http://purl.obolibrary.org/obo/HP_0034065		
HP:0034064	biolink:PhenotypicFeature	Anti-salivary protein antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against salivary protein.		hp.json	Anti-SP1 antibody positivity	http://purl.obolibrary.org/obo/HP_0034064		
HP:0034061	biolink:PhenotypicFeature	Anti-steroid 17alpha-hydroxylase antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against steroid 17alpha-hydroxylase.		hp.json	Anti-P450C17	http://purl.obolibrary.org/obo/HP_0034061		
HP:0034060	biolink:PhenotypicFeature	Triggered by fava bean ingestion	Applies to a sign or symptom that is provoked or brought about by eating fava beans.		hp.json		http://purl.obolibrary.org/obo/HP_0034060		
CL:0000457	biolink:Cell	biogenic amine secreting cell			hp.json		http://purl.obolibrary.org/obo/CL_0000457		
CL:0000458	biolink:Cell	serotonin secreting cell	A cell type that secretes 5-Hydroxytryptamine (serotonin).		hp.json	5-Hydroxytryptamine secreting cell|5-HT secreting cell	http://purl.obolibrary.org/obo/CL_0000458		
CL:0000459	biolink:Cell	noradrenergic cell	A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme.		hp.json	noradrenaline secreting cell|norepinephrine secreting cell|norepinephrin secreting cell	http://purl.obolibrary.org/obo/CL_0000459		
HP:0034067	biolink:PhenotypicFeature	Tonofilament clumping	Formation of lumps of tonofilaments, which are bundles of keratin filaments. In some but not all epithelia, keratin filaments are conspicuously bundled as tonofilaments. Inside the cell they braid the nucleus, span through the cytoplasm and are attached to the cytoplasmic plaques of the typical epithelial cell-cell junctions, the desmosomes.		hp.json	Clumping of the keratin tonofilaments	http://purl.obolibrary.org/obo/HP_0034067		
UBERON:0010850	biolink:AnatomicalEntity	tibia pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a tibia.	EHDAA2:0002036	hp.json		http://purl.obolibrary.org/obo/UBERON_0010850		
HP:0034066	biolink:PhenotypicFeature	Anti-carbonic anhydrase VI antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against carbonic anhydrase VI.		hp.json	Anti-CA6 antibody positivity	http://purl.obolibrary.org/obo/HP_0034066		
UBERON:0010851	biolink:AnatomicalEntity	fibula cartilage element	A cartilaginous condensation that has the potential to develop into a fibula.	EMAPA:18154	hp.json	fibulal cartilage condensation|fibular cartilage condensation|fibulra cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010851		
HP:0034069	biolink:PhenotypicFeature	Anti-parotid secretory protein antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against parotid secretory protein.		hp.json	Anti-PSP antibody positivity	http://purl.obolibrary.org/obo/HP_0034069		
HP:0034068	biolink:PhenotypicFeature	Anti-plasminogen binding peptide antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against plasminogen binding peptide.		hp.json	Anti-PBP antibody positivity	http://purl.obolibrary.org/obo/HP_0034068		
UBERON:0010843	biolink:AnatomicalEntity	clavicle cartilage element	A cartilaginous condensation that has the potential to develop into a clavicle.	EMAPA:18342	hp.json		http://purl.obolibrary.org/obo/UBERON_0010843		
UBERON:0010844	biolink:AnatomicalEntity	clavicle pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a clavicle.	EMAPA:18026	hp.json		http://purl.obolibrary.org/obo/UBERON_0010844		
CL:0000451	biolink:Cell	dendritic cell	A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).	CALOHA:TS-0194|FMA:83036|BTO:0002042	hp.json	interdigitating cell|veiled cell	http://purl.obolibrary.org/obo/CL_0000451		
UBERON:0010842	biolink:AnatomicalEntity	calcaneum cartilage element	A calcaneum endochondral element that is composed primarily of cartilage tissue.	EMAPA:18143	hp.json	calcaneous cartilage element	http://purl.obolibrary.org/obo/UBERON_0010842		
CL:0000453	biolink:Cell	Langerhans cell	Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus.	FMA:63072|CALOHA:TS-2375|BTO:0000705	hp.json	LC|Langerhans' cell	http://purl.obolibrary.org/obo/CL_0000453		
UBERON:0010847	biolink:AnatomicalEntity	ulna pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a ulna.	EHDAA:6226|EHDAA2:0002100	hp.json		http://purl.obolibrary.org/obo/UBERON_0010847		
CL:0000454	biolink:Cell	epinephrine secreting cell	A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types.		hp.json	epinephrin secreting cell|adrenaline secreting cell	http://purl.obolibrary.org/obo/CL_0000454		
UBERON:0010848	biolink:AnatomicalEntity	radius-ulna cartilage element	A radius-ulna endochondral element that is composed primarily of cartilage tissue.	EMAPA:17711	hp.json	radio-ulna cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010848		
UBERON:0010846	biolink:AnatomicalEntity	radius pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a radius bone.	EHDAA2:0001586	hp.json		http://purl.obolibrary.org/obo/UBERON_0010846		
UBERON:0010849	biolink:AnatomicalEntity	tibia cartilage element	A cartilaginous condensation that has the potential to develop into a tibia.	EMAPA:18155	hp.json		http://purl.obolibrary.org/obo/UBERON_0010849		
UBERON:0007204	biolink:AnatomicalEntity	brachiocephalic vasculature	The vasculature consisting of brachiocephalic arteries and veins.		hp.json		http://purl.obolibrary.org/obo/UBERON_0007204		
HP:0034074	biolink:PhenotypicFeature	Increased fetal long bone echogenicity	An abnormally elevated echogenicity of fetal long bones in a prenatal sonographic investigation. Ths finding is due to hypermineralization.		hp.json		http://purl.obolibrary.org/obo/HP_0034074		
HP:0034073	biolink:PhenotypicFeature	Reduced fetal long bone echogenicity	An abnormally decreased echogenicity of fetal long bones in a prenatal sonographic investigation. Ths finding is due to hypomineralization and can be seen in some disorders such as hypophosphatasia, osteogenesis imperfecta, and achondrogenesis.		hp.json		http://purl.obolibrary.org/obo/HP_0034073		
HP:0034076	biolink:PhenotypicFeature	Anti-ribosome Po antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against ribosome Po.		hp.json		http://purl.obolibrary.org/obo/HP_0034076		
HP:0034075	biolink:PhenotypicFeature	Decreased circulating apolipoprotein B concentration	Reduced circulating level of apolipoprotein B, which is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100.		hp.json		http://purl.obolibrary.org/obo/HP_0034075		
CHEBI:52214	biolink:ChemicalSubstance	ligand	Any molecule or ion capable of binding to a central metal atom to form coordination complexes.	Wikipedia:Ligand	hp.json	ligands	http://purl.obolibrary.org/obo/CHEBI_52214		3_STAR
HP:0034070	biolink:PhenotypicFeature	Anti-enterocyte antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against enterocytes.		hp.json	AEA	http://purl.obolibrary.org/obo/HP_0034070		
CHEBI:52215	biolink:ChemicalSubstance	photochemical role	A  chemical role played by the molecular entity or part thereof in a photochemical process.		hp.json	photochemical roles	http://purl.obolibrary.org/obo/CHEBI_52215		3_STAR
HP:0034072	biolink:PhenotypicFeature	Abnormal fetal long-bone echogenicity	Any deviation from the normal appearing echogenicity of the fetal bone. Echogenicity refers to the ability of tissue to reflect ultrasound waves back toward the transducer and produce an echo. Whenever there is an interface of structures with different echogenicities, a visible difference in contrast will be apparent on the screen. The higher the echogenicity of tissues, the brighter they appear on ultrasound imaging.		hp.json		http://purl.obolibrary.org/obo/HP_0034072		
CHEBI:52217	biolink:ChemicalSubstance	pharmaceutical	Any substance introduced into a living organism with therapeutic or diagnostic purpose.		hp.json	pharmaceuticals|medicament|farmaco	http://purl.obolibrary.org/obo/CHEBI_52217		3_STAR
HP:0034071	biolink:PhenotypicFeature	Anti-21-hydroxylase antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against 21-hydroxylase.		hp.json	Anti-P450c21	http://purl.obolibrary.org/obo/HP_0034071		
HP:0034078	biolink:PhenotypicFeature	Anti-centromere protein A antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CENP-A.		hp.json	Anti-CENP-A antibody positivity	http://purl.obolibrary.org/obo/HP_0034078		
HP:0034077	biolink:PhenotypicFeature	Anti-complement component C1q antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against C1q.		hp.json	Anti-C1q antibody positivity	http://purl.obolibrary.org/obo/HP_0034077		
HP:0034079	biolink:PhenotypicFeature	Anti-centromere protein B antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against CENP-B.		hp.json	Anti-CENP-B antibody positivity	http://purl.obolibrary.org/obo/HP_0034079		
UBERON:0009854	biolink:AnatomicalEntity	digestive tract diverticulum	Branch or outpocketing of the digestive tract.	FBbt:00100316	hp.json	intestinal pouch|diverticulum of gut	http://purl.obolibrary.org/obo/UBERON_0009854		
UBERON:0009856	biolink:AnatomicalEntity	sac		galen:Diverticulum	hp.json	pouch|diverticulum	http://purl.obolibrary.org/obo/UBERON_0009856		
UBERON:0009857	biolink:AnatomicalEntity	cavum septum pellucidum	A space enclosed within the laminae of the septum pelludicum, the membranous partition that seperates the frontal horns of the ventricle. contains cerebrospinal fluid (CSF) that filters from the ventricles through the septal laminae. bounded anteriorly by the genu of the corpus callosum; superiorly by the body of the corpus callosum; posteriorly by the anterior limb and pillars of the fornix; inferiorly by the anterior commissure and the rostrum of the corpus callosum; and laterally by the leaflets of the septum pellucidum.	NCIT:C32602|UMLS:C0228158|BAMS:CSP|FMA:61874|DHBA:12099|BTO:0003447	hp.json	ventriculus septi pellucidi|cavum septi pellucidi|septum pellucidum cave|fifth ventricle|cave of septum pellucidum|cavum of septum pellucidum|cavum septi pellucidi	http://purl.obolibrary.org/obo/UBERON_0009857		
UBERON:0009859	biolink:AnatomicalEntity	endosteum	A thin layer of connective tissue that lines the surface of the bony tissue that forms the medullary cavity of long bones.	NCIT:C13183|FMA:32692|UMLS:C0222658	hp.json		http://purl.obolibrary.org/obo/UBERON_0009859		pheno_slim
CHEBI:52210	biolink:ChemicalSubstance	pharmacological role	A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties.		hp.json		http://purl.obolibrary.org/obo/CHEBI_52210		3_STAR
CHEBI:52211	biolink:ChemicalSubstance	physiological role			hp.json		http://purl.obolibrary.org/obo/CHEBI_52211		1_STAR
HP:0034085	biolink:PhenotypicFeature	Anti-PM-Scl100 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against PM-Scl100.		hp.json		http://purl.obolibrary.org/obo/HP_0034085		
CHEBI:52208	biolink:ChemicalSubstance	biophysical role			hp.json		http://purl.obolibrary.org/obo/CHEBI_52208		1_STAR
HP:0034084	biolink:PhenotypicFeature	Anti-phosphatidyl ethanolamine antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against phosphatidyl ethanolamine.		hp.json		http://purl.obolibrary.org/obo/HP_0034084		
HP:0034087	biolink:PhenotypicFeature	Anti-U11/U12 RNP antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against U11/U12 RNP.		hp.json		http://purl.obolibrary.org/obo/HP_0034087		
CHEBI:52209	biolink:ChemicalSubstance	aetiopathogenetic role	A role played by the molecular entity or part thereof which causes the development of a pathological process.		hp.json	etiopathogenetic role|etiopathogenetic agent	http://purl.obolibrary.org/obo/CHEBI_52209		3_STAR
HP:0034086	biolink:PhenotypicFeature	Anti-PM-Scl75 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against PM-Scl75.		hp.json		http://purl.obolibrary.org/obo/HP_0034086		
HP:0034081	biolink:PhenotypicFeature	Anti-Th/To antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Th/To.		hp.json		http://purl.obolibrary.org/obo/HP_0034081		
UBERON:5002389	biolink:AnatomicalEntity	manual digit plus metapodial segment	A subdivision of the autopod consisting of manual digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	manual digit ( phalanges plus metapodial) plus soft tissue|manual digit ray|manual digit digitopodial subdivision|manual digit	http://purl.obolibrary.org/obo/UBERON_5002389		
HP:0034080	biolink:PhenotypicFeature	Anti-U3 RNP antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against U3 RNP.		hp.json	Anti-fibrillarin antibody positivity	http://purl.obolibrary.org/obo/HP_0034080		
HP:0034083	biolink:PhenotypicFeature	Anti-nucleolus-organizing region antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Nor90.		hp.json	Anti-Nor90 antibody positivity	http://purl.obolibrary.org/obo/HP_0034083		
HP:0034082	biolink:PhenotypicFeature	Anti-bicaudal D2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against bicaudal D2.		hp.json	Anti-BICD2 antibody positivity	http://purl.obolibrary.org/obo/HP_0034082		
CHEBI:52206	biolink:ChemicalSubstance	biochemical role	A biological role played by the molecular entity or part thereof within a biochemical context.		hp.json		http://purl.obolibrary.org/obo/CHEBI_52206		3_STAR
CHEBI:27266	biolink:ChemicalSubstance	valine	A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.	CAS:516-06-3|CAS:516-06-3|Wikipedia:Valine|Beilstein:506689|PMID:22770225|Reaxys:506689|KEGG:C16436|PMID:17190852|Gmelin:49877|CAS:516-06-3	hp.json	valine|2-amino-3-methylbutanoic acid|valina|Hval|Valin|DL-valine	http://purl.obolibrary.org/obo/CHEBI_27266		3_STAR
CL:0000438	biolink:Cell	luteinizing hormone secreting cell	A peptide hormone secreting cell pituitary that produces luteinizing hormone.		hp.json		http://purl.obolibrary.org/obo/CL_0000438		
CL:0000439	biolink:Cell	prolactin secreting cell	A peptide hormone cell that secretes prolactin.		hp.json		http://purl.obolibrary.org/obo/CL_0000439		
HP:0034089	biolink:PhenotypicFeature	Anti-B23 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against B23.		hp.json		http://purl.obolibrary.org/obo/HP_0034089		
HP:0034088	biolink:PhenotypicFeature	Anti-Ku antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against Ku.		hp.json		http://purl.obolibrary.org/obo/HP_0034088		
UBERON:0009843	biolink:AnatomicalEntity	prostate epithelial cord	A solid cord of prostate epithelium.		hp.json	cord of prostate epithelium|epithelial cord of prostate	http://purl.obolibrary.org/obo/UBERON_0009843		
UBERON:0009844	biolink:AnatomicalEntity	urogenital sinus lumen	An anatomical space that surrounded_by a primitive urogenital sinus.	EHDAA2:0002142	hp.json		http://purl.obolibrary.org/obo/UBERON_0009844		
UBERON:0009845	biolink:AnatomicalEntity	urogenital sinus mesenchyme	Mesenchyme that surrounds primitive urogenital sinus.	EMAPA:31500	hp.json	UGM	http://purl.obolibrary.org/obo/UBERON_0009845		
UBERON:0009846	biolink:AnatomicalEntity	embryonic cloacal epithelium	An epithelium that is part of a embryonic cloaca.	EHDAA2:0004585	hp.json	cloacal epithelium	http://purl.obolibrary.org/obo/UBERON_0009846		
UBERON:0009847	biolink:AnatomicalEntity	prostate field	A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop.		hp.json	prostate primordium	http://purl.obolibrary.org/obo/UBERON_0009847		
CL:0000432	biolink:Cell	reticular cell	Large, stellate fibroblast found along the network of collagen fibers of the reticulum of the spleen; synthesize the matrix components of the reticulum.	FMA:62877	hp.json	reticulum cell	http://purl.obolibrary.org/obo/CL_0000432		
HP:0034090	biolink:PhenotypicFeature	Anti-RuvBL1/2 antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against RuvBL1/2.		hp.json		http://purl.obolibrary.org/obo/HP_0034090		
UBERON:0009842	biolink:AnatomicalEntity	glandular acinus	The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form.	Wikipedia:Acinus|FMA:55588	hp.json	acini|acinus|acini	http://purl.obolibrary.org/obo/UBERON_0009842		
HP:0010041	biolink:PhenotypicFeature	Short 3rd metacarpal	Short third metacarpal bone.	UMLS:C1850631	hp.json	Small 3rd metacarpals|Shortened 3rd long bone of hand|Short third metacarpals|Hypoplastic 3rd metacarpal	http://purl.obolibrary.org/obo/HP_0010041		
HP:0010040	biolink:PhenotypicFeature	Aplasia of the 3rd metacarpal	Absence of the third long bone of the hand.	UMLS:C4024088	hp.json	Absent 3rd long bone of hand	http://purl.obolibrary.org/obo/HP_0010040		
HP:0009051	biolink:PhenotypicFeature	Increased muscle glycogen content	An increased amount of glycogen in muscle tissue.	UMLS:C1968729	hp.json		http://purl.obolibrary.org/obo/HP_0009051		
HP:0034010	biolink:PhenotypicFeature	Increased megakaryocyte colony forming unit count	Increased numbers of megakryocyte precursors (megakaryocyte colony forming units) in the bone marrow.		hp.json		http://purl.obolibrary.org/obo/HP_0034010		
HP:0009054	biolink:PhenotypicFeature	Scapuloperoneal myopathy		UMLS:C2931268|MSH:C536624	hp.json		http://purl.obolibrary.org/obo/HP_0009054		
HP:0009053	biolink:PhenotypicFeature	Distal lower limb muscle weakness	Reduced strength of the distal musculature of the legs.	UMLS:C1836450	hp.json	Distal muscle weakness in lower limbs|Muscle weakness, lower limb, distal	http://purl.obolibrary.org/obo/HP_0009053		
HP:0009050	biolink:PhenotypicFeature	Quadriceps muscle atrophy	Muscular atrophy involving the quadriceps muscle.	UMLS:C4024603	hp.json	Wasting of quad muscles	http://purl.obolibrary.org/obo/HP_0009050		
HP:0034016	biolink:PhenotypicFeature	Anti-HLA antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen (HLA).		hp.json	Anti-human leukocyte antigen antibody positivity	http://purl.obolibrary.org/obo/HP_0034016		
HP:0010049	biolink:PhenotypicFeature	Short metacarpal	Diminished length of one or more metacarpal bones in relation to the others of the same hand or to the contralateral metacarpal.	UMLS:C1837084	hp.json	Brachymetacarpalia|Short metacarpals|Shortening of metacarpals|Shortened long bones of hand|Shortened long bone of hand|Hypoplastic metacarpal|Shortened metacarpals|Short metacarpal bones|Metacarpal hypoplasia	http://purl.obolibrary.org/obo/HP_0010049		hposlim_core
HP:0034015	biolink:PhenotypicFeature	Cavitating pulmonary nodule	Thick-walled abnormal gas-filled interstitial nodule within a lung.		hp.json		http://purl.obolibrary.org/obo/HP_0034015		
HP:0010048	biolink:PhenotypicFeature	Aplasia of metacarpal bones	Developmental defect associated with absence of one or more metacarpal bones.	UMLS:C1846473	hp.json	Absent long bone of hand|Absent metacarpal|Absent metacarpals	http://purl.obolibrary.org/obo/HP_0010048		hposlim_core
HP:0010047	biolink:PhenotypicFeature	Short 5th metacarpal	Short fifth metacarpal bone.	UMLS:C1861388	hp.json	Shortened 5th long bone of hand|Hypoplastic 5th metacarpal|Fifth metacarpal hypoplasia|Short fifth metacarpals|Short fifth metacarpal	http://purl.obolibrary.org/obo/HP_0010047		
HP:0034018	biolink:PhenotypicFeature	Anti-class II HLA antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a class I human leukocyte antigen (HLA). Class I HLA corresponds to MHC class II (DP, DM, DO, DQ, and DR).		hp.json		http://purl.obolibrary.org/obo/HP_0034018		
HP:0010046	biolink:PhenotypicFeature	Aplasia of the 5th metacarpal	Absence of the fifth long bone of the hand.	UMLS:C1867929	hp.json	Absent 5th long bone of hand|Absent 5th metacarpal	http://purl.obolibrary.org/obo/HP_0010046		
HP:0034017	biolink:PhenotypicFeature	Anti-class I HLA antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a class I human leukocyte antigen (HLA). Class I HLA corresponds to MHC class I (A, B, and C).		hp.json		http://purl.obolibrary.org/obo/HP_0034017		
HP:0010045	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 5th metacarpal	Aplasia or Hypoplasia affecting the 5th metacarpal.	UMLS:C4024085	hp.json	Absent/small 5th long bone of hand|Absent/underdeveloped 5th long bone of hand	http://purl.obolibrary.org/obo/HP_0010045		
HP:0034012	biolink:PhenotypicFeature	Palmoplantar hypohidrosis	Decreased sweating on the palms and soles.		hp.json		http://purl.obolibrary.org/obo/HP_0034012		
HP:0010044	biolink:PhenotypicFeature	Short 4th metacarpal	Short fourth metacarpal bone.	UMLS:C1840309	hp.json	Shortened 4th long bone of hand|Short fourth metacarpals|Hypoplastic fourth metacarpal|Short 4th metacarpals	http://purl.obolibrary.org/obo/HP_0010044		
HP:0034011	biolink:PhenotypicFeature	Reduced progressive sperm motility	A reduced proportion of sperm that move in a straight line or large circles; alternatively, an increaed proportion of sperm that move in tight circles or in some other non-linear fashion.		hp.json	Non-progressive sperm motility	http://purl.obolibrary.org/obo/HP_0034011		
HP:0010043	biolink:PhenotypicFeature	Aplasia of the 4th metacarpal	Absence of the fourth long bone of the hand.	UMLS:C4024086	hp.json	Absent 4th long bone of hand	http://purl.obolibrary.org/obo/HP_0010043		
HP:0034014	biolink:PhenotypicFeature	Tubulonodular pericallosal lipoma	A type of pericallosal lipoma with a rounded or lobular appearance and a diameter that is usually above 2 cm. They are anteriorly situated and are associated with extensive callosal and often fronto-facial anomalies. A tubulonodular pericallosal lipoma can extend into the choroid plexus or lateral ventricles.		hp.json		http://purl.obolibrary.org/obo/HP_0034014		
HP:0034013	biolink:PhenotypicFeature	Curvilinear pericallosal lipoma	A type of pericallosal lipoma that is thin and curves around the posterior end of the splenium of the corpus callosum.		hp.json		http://purl.obolibrary.org/obo/HP_0034013		
HP:0010042	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 4th metacarpal	Aplasia or Hypoplasia affecting the 4th metacarpal.	UMLS:C4024087	hp.json	Absent/small 4th long bone of hand|Absent/underdeveloped 4th long bone of hand	http://purl.obolibrary.org/obo/HP_0010042		
HP:0034019	biolink:PhenotypicFeature	Anti-HLA-A antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen-A (HLA-A).		hp.json		http://purl.obolibrary.org/obo/HP_0034019		
HP:0009049	biolink:PhenotypicFeature	Peroneal muscle atrophy	Atrophy of the peroneous muscles, peroneus longus (also known as Fibularis longus), Peroneus brevis (also known as fibularis brevis, and Peroneus tertius (also known as fibularis tertius).	UMLS:C1389118	hp.json	Peroneal atrophy	http://purl.obolibrary.org/obo/HP_0009049		
HP:0009045	biolink:PhenotypicFeature	Exercise-induced rhabdomyolysis	Rhabdomyolysis induced by exercise.	UMLS:C4021526	hp.json	Rhabdomyolysis with exercise	http://purl.obolibrary.org/obo/HP_0009045		
HP:0009044	biolink:PhenotypicFeature	obsolete Hypoplasia of deltoid muscle			hp.json		http://purl.obolibrary.org/obo/HP_0009044		
HP:0009046	biolink:PhenotypicFeature	Difficulty running	Reduced ability to run.	SNOMEDCT_US:282479002|UMLS:C0560346	hp.json	Difficulty running	http://purl.obolibrary.org/obo/HP_0009046		
HP:0010030	biolink:PhenotypicFeature	Osteolytic defects of the 1st metacarpal	Dissolution or degeneration of bone tissue of the 1st metacarpal.	UMLS:C4024094	hp.json		http://purl.obolibrary.org/obo/HP_0010030		
HP:0012693	biolink:PhenotypicFeature	Abnormal thalamic size	Deviation from the normal range of size of the thalamus.	UMLS:C4022773	hp.json		http://purl.obolibrary.org/obo/HP_0012693		
HP:0009063	biolink:PhenotypicFeature	Progressive distal muscle weakness	Progressively reduced strength of the distal musculature.	UMLS:C1836609	hp.json	Muscle weakness, distal, progressive|Muscle weakness, progressive, distal	http://purl.obolibrary.org/obo/HP_0009063		
HP:0009062	biolink:PhenotypicFeature	Infantile axial hypotonia	Muscular hypotonia (abnormally low muscle tone) affecting the musculature of the trunk and with onset in infancy.	UMLS:C3806604	hp.json	Hypotonia, axial, in infancy	http://purl.obolibrary.org/obo/HP_0009062		
HP:0012694	biolink:PhenotypicFeature	Enlarged thalamic volume	An increase in the quantity of space occupied by the thalamus.	UMLS:C4022772	hp.json		http://purl.obolibrary.org/obo/HP_0012694		
HP:0034021	biolink:PhenotypicFeature	Anti-HLA-A IgG3 antibody positivity	The presence of IgG3 autoantibodies in the blood circulation that react against a human leukocyte antigen-A (HLA-A).		hp.json		http://purl.obolibrary.org/obo/HP_0034021		
HP:0012695	biolink:PhenotypicFeature	Decreased thalamic volume	A reduction in the quantity of space occupied by the thalamus.	UMLS:C4022771	hp.json		http://purl.obolibrary.org/obo/HP_0012695		
HP:0009064	biolink:PhenotypicFeature	Generalized lipodystrophy	Generalized degenerative changes of the fat tissue.	UMLS:C0221032|SNOMEDCT_US:284449005|MSH:D052497|SNOMEDCT_US:86907008	hp.json	Generalised lipodystrophy|Lipodystrophy, generalized|Lipodystrophy, generalised	http://purl.obolibrary.org/obo/HP_0009064		
HP:0034020	biolink:PhenotypicFeature	Anti-HLA-A IgG1 antibody positivity	The presence of IgG1 autoantibodies in the blood circulation that react against a human leukocyte antigen-A (HLA-A).		hp.json		http://purl.obolibrary.org/obo/HP_0034020		
HP:0012696	biolink:PhenotypicFeature	Abnormal thalamic MRI signal intensity	A deviation from normal signal on magnetic resonance imaging (MRI) of the thalamus.	UMLS:C4022770	hp.json		http://purl.obolibrary.org/obo/HP_0012696		
HP:0012697	biolink:PhenotypicFeature	Small basal ganglia	Decreased size of the basal ganglia.	UMLS:C4022769	hp.json		http://purl.obolibrary.org/obo/HP_0012697		
HP:0012698	biolink:PhenotypicFeature	Cerebellar gliosis	Focal proliferation of glial cells in the cerebellum.	UMLS:C4022768	hp.json		http://purl.obolibrary.org/obo/HP_0012698		
HP:0012699	biolink:PhenotypicFeature	Anomaly of lower limb diaphyses	A structural abnormality of a diaphysis of the leg.	UMLS:C4022767	hp.json	Anomaly of shaft of long bone of lower limb	http://purl.obolibrary.org/obo/HP_0012699		
HP:0009060	biolink:PhenotypicFeature	Scapular muscle atrophy	Atrophy of the muscles that are responsible for moving the scapula, which are the levator scapulae, the infraspinatus muscle, the teres major, the teres minor, and the supraspinatus muscle.	UMLS:C3805969	hp.json		http://purl.obolibrary.org/obo/HP_0009060		
HP:0034027	biolink:PhenotypicFeature	Abnormal urinary non-proteinogenic amino acid level	Any deviation from the normal amount in the urine of an alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.		hp.json		http://purl.obolibrary.org/obo/HP_0034027		
HP:0010038	biolink:PhenotypicFeature	Short 2nd metacarpal	Short second metacarpal bone because of developmental hypoplasia.	UMLS:C4020774|UMLS:C1969397	hp.json	Shortened 2nd long bone of hand|Rudimentary 2nd metacarpal|Hypoplastic 2nd metacarpal	http://purl.obolibrary.org/obo/HP_0010038		
HP:0010037	biolink:PhenotypicFeature	Aplasia of the 2nd metacarpal	Absence of the second long bone of the hand.	UMLS:C4024090	hp.json	Absent 2nd long bone of hand	http://purl.obolibrary.org/obo/HP_0010037		
HP:0034026	biolink:PhenotypicFeature	Elevated circulating sacchoropine concentration	An increased concentration of saccharopine in the blood circulation. L-saccharopine is the N(6)-(1,3-dicarboxypropan-1-yl) derivative of L-lysine.		hp.json		http://purl.obolibrary.org/obo/HP_0034026		
HP:0034029	biolink:PhenotypicFeature	Hepatic foam cells	The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, in the liver.		hp.json		http://purl.obolibrary.org/obo/HP_0034029		
HP:0010036	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 2nd metacarpal	Aplasia or Hypoplasia affecting the 2nd metacarpal.	UMLS:C4024091	hp.json	Absent/small 2nd long bone of hand|Absent/underdeveloped 2nd long bone of hand	http://purl.obolibrary.org/obo/HP_0010036		
HP:0034028	biolink:PhenotypicFeature	Saccharopinuria	Presence of saccharopine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0034028		
HP:0010035	biolink:PhenotypicFeature	Aplasia of the 1st metacarpal	Absent first metacarpal (long bone) of the hand.	UMLS:C1838610	hp.json	Absent 1st long bone of hand|Absent first metacarpal	http://purl.obolibrary.org/obo/HP_0010035		
HP:0010034	biolink:PhenotypicFeature	Short 1st metacarpal	A developmental defect characterized by reduced length of the first metacarpal (long bone) of the hand.	UMLS:C1849311	hp.json	First metacarpals hypoplastic|Short first metacarpals|Short first metacarpal|Shortened 1st long bone of hand|Hypoplastic 1st metacarpal|First metacarpal hypoplasia	http://purl.obolibrary.org/obo/HP_0010034		hposlim_core
HP:0034023	biolink:PhenotypicFeature	Anti-HLA-B IgG1 antibody positivity	The presence of IgG1 autoantibodies in the blood circulation that react against a human leukocyte antigen-B (HLA-B).		hp.json		http://purl.obolibrary.org/obo/HP_0034023		
HP:0012690	biolink:PhenotypicFeature	T2 hypointense thalamus	A darker than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a diffuse hypointensity affecting the entire thalamus.	UMLS:C4022776	hp.json		http://purl.obolibrary.org/obo/HP_0012690		
HP:0010033	biolink:PhenotypicFeature	Triangular shaped 1st metacarpal	This term applies to a triangular shaped 1st metacarpal.	UMLS:C4024092	hp.json	Triangular shaped 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010033		
HP:0034022	biolink:PhenotypicFeature	Anti-HLA-B antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against a human leukocyte antigen-B (HLA-B).		hp.json		http://purl.obolibrary.org/obo/HP_0034022		
HP:0034025	biolink:PhenotypicFeature	Abnormal circulating GABA concentration	Any deviation from the normal concentration of gamma-aminobutyric acid (GABA) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0034025		
HP:0012691	biolink:PhenotypicFeature	Focal T2 hypointense thalamic lesion	A darker than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a localized hypointensity affecting a particular region of the thalamus.	UMLS:C4022775	hp.json		http://purl.obolibrary.org/obo/HP_0012691		
HP:0010031	biolink:PhenotypicFeature	Patchy sclerosis of the 1st metacarpal	Uneven increase in bone density within the 1st metacarpal.	UMLS:C4024093	hp.json	Uneven increase in bone density in 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010031		
HP:0012692	biolink:PhenotypicFeature	Focal T2 hyperintense thalamic lesion	A lighter than expected T2 signal on magnetic resonance imaging (MRI) of the thalamus. This term refers to a localized hyperintensity affecting a particular region of the thalamus.	UMLS:C4022774	hp.json		http://purl.obolibrary.org/obo/HP_0012692		
HP:0034024	biolink:PhenotypicFeature	Anti-HLA-B IgG3 antibody positivity	The presence of IgG3 autoantibodies in the blood circulation that react against a human leukocyte antigen-B (HLA-B).		hp.json		http://purl.obolibrary.org/obo/HP_0034024		
HP:0010039	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 3rd metacarpal	Aplasia or Hypoplasia affecting the 3rd metacarpal.	UMLS:C4024089	hp.json	Absent/underdeveloped 3rd long bone of hand|Absent/small 3rd long bone of hand	http://purl.obolibrary.org/obo/HP_0010039		
HP:0009059	biolink:PhenotypicFeature	Congenital generalized lipodystrophy		SNOMEDCT_US:86907008|UMLS:C0221032|SNOMEDCT_US:284449005|MSH:D052497	hp.json	Congenital generalised lipodystrophy	http://purl.obolibrary.org/obo/HP_0009059		
HP:0009056	biolink:PhenotypicFeature	Loss of subcutaneous adipose tissue from upper limbs		UMLS:C4024602	hp.json	Loss of fat tissue below the skin from upper limbs	http://purl.obolibrary.org/obo/HP_0009056		
HP:0009055	biolink:PhenotypicFeature	Generalized limb muscle atrophy	Generalized (unlocalized) atrophy affecting muscles of the limbs in both proximal and distal locations.	UMLS:C1838114	hp.json	Generalised muscle atrophy, proximal and distal|Generalized muscle wasting|Generalised muscle wasting|Generalized muscle atrophy, proximal and distal|Generalised limb muscle atrophy	http://purl.obolibrary.org/obo/HP_0009055		
HP:0009058	biolink:PhenotypicFeature	Increased muscle lipid content	An abnormal accumulation of lipids in skeletal muscle.	UMLS:C1837262	hp.json	Increased muscle lipid content|Lipid accumulation in skeletal muscle|Muscle lipidosis|Fat accumulation in muscle fibres|Fat deposits in muscle fibres|Fat accumulation in muscle fibers|Skeletal muscle lipid accumulation|Fat deposits in muscle fibers	http://purl.obolibrary.org/obo/HP_0009058		
GO:1990009	biolink:BiologicalProcess	retinal cell apoptotic process	Any apoptotic process in a retinal cell.		hp.json	induction of retinal programmed cell death	http://purl.obolibrary.org/obo/GO_1990009		
HP:0012682	biolink:PhenotypicFeature	Pineal gland calcification	Accumulation of calcium salts in the pineal gland.	UMLS:C1398718	hp.json		http://purl.obolibrary.org/obo/HP_0012682		
HP:0034030	biolink:PhenotypicFeature	Lip cyanosis	Bluish discoloration of the lips.		hp.json	Cyanotic lips|Labial cyanosis|Bluish lips	http://purl.obolibrary.org/obo/HP_0034030		
HP:0012683	biolink:PhenotypicFeature	Pineal cyst	A glial uniloculated or multiloculated fluid-filled sac that either reside within or completely replace the pineal gland.	SNOMEDCT_US:413099000|UMLS:C1335411	hp.json		http://purl.obolibrary.org/obo/HP_0012683		
HP:0034032	biolink:PhenotypicFeature	Central cyanosis	Generalized bluish discoloration of the body and the visible mucous membranes, which occurs due to inadequate oxygenation secondary to conditions that lead to an increase in deoxygenated hemoglobin or presence of abnormal hemoglobin.		hp.json		http://purl.obolibrary.org/obo/HP_0034032		
HP:0012684	biolink:PhenotypicFeature	Abnormal pineal volume	An abnormal increase or decrease in the quantity of three-dimensional space taken up by the pineal gland.	UMLS:C4022781	hp.json		http://purl.obolibrary.org/obo/HP_0012684		
HP:0009031	biolink:PhenotypicFeature	Amyotrophy of ankle musculature	Atrophy of the muscles of the ankle.	UMLS:C4024604	hp.json		http://purl.obolibrary.org/obo/HP_0009031		
HP:0034031	biolink:PhenotypicFeature	Facial cyanosis	Bluish discoloration of one or more regions of the face.		hp.json	Bluish face|Cyanotic face	http://purl.obolibrary.org/obo/HP_0034031		
HP:0012685	biolink:PhenotypicFeature	Decreased pineal volume	An abnormal reduction in the quantity of three-dimensional space taken up by the pineal gland.	UMLS:C4022780	hp.json		http://purl.obolibrary.org/obo/HP_0012685		
HP:0012686	biolink:PhenotypicFeature	Increased pineal volume	An abnormal elevation in the quantity of three-dimensional space taken up by the pineal gland.	UMLS:C4022779	hp.json		http://purl.obolibrary.org/obo/HP_0012686		
GO:1990010	biolink:BiologicalProcess	compound eye retinal cell apoptotic process	Any apoptotic process in a compound eye retinal cell.		hp.json		http://purl.obolibrary.org/obo/GO_1990010		
HP:0012687	biolink:PhenotypicFeature	Agenesis of pineal gland	Failure to develop of the pineal gland, defined clinically as the absence of the pineal gland with no indication of the pineal gland even having been present.	UMLS:C3553078	hp.json		http://purl.obolibrary.org/obo/HP_0012687		
HP:0012688	biolink:PhenotypicFeature	Abnormality of pineal physiology	A functional abnormality of the pineal gland.	UMLS:C4022778	hp.json		http://purl.obolibrary.org/obo/HP_0012688		
HP:0012689	biolink:PhenotypicFeature	Abnormal pineal melatonin secretion	An anomaly in the amount or timing of melatonin secretion by the pineal gland. Note that melatonin is also synthesized by multiple tissues outside of the pineal gland.	UMLS:C4022777	hp.json		http://purl.obolibrary.org/obo/HP_0012689		
HP:0010027	biolink:PhenotypicFeature	Broad 1st metacarpal	Increased width of the 1st metacarpal. In contrast to the proximal phalanges of the digits 2-5, the proximal phalanx of the thumb is embryologically equivalent to the middle phalanges of the other digits, whereas the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the other digits.	UMLS:C4024097	hp.json	Wide 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010027		
HP:0034038	biolink:PhenotypicFeature	Silent hypoxemia	Abnormally low blood oxygen level without the presence of dyspnea.		hp.json		http://purl.obolibrary.org/obo/HP_0034038		
HP:0010026	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 1st metacarpal	Aplasia or Hypoplasia affecting the 1st metacarpal. In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits).	UMLS:C4024098	hp.json	Absent/underdeveloped 1st long bone of hand|Absent/small 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010026		
HP:0034037	biolink:PhenotypicFeature	Pseudo-chilblains on fingers	Inflammatory chilblain-like nodules on the hands and/or fingers.		hp.json	COVID finger|COVID fingers	http://purl.obolibrary.org/obo/HP_0034037		
HP:0010025	biolink:PhenotypicFeature	Triangular epiphysis of the 1st metacarpal		UMLS:C4024099	hp.json	Triangular end part of the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010025		
HP:0010024	biolink:PhenotypicFeature	Epiphyseal stippling of the first metacarpal	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the first metacarpal bone.	UMLS:C4021345	hp.json	Stippling of the epiphysis of the 1st metacarpal|Speckled calcifications in the end part of the first long bone of hand	http://purl.obolibrary.org/obo/HP_0010024		
HP:0034039	biolink:PhenotypicFeature	Ventricular couplet	Two consecutive premature ventricular contractions (PVCs) with no intervening normal beats.		hp.json	Doublet premature ventricular contractions	http://purl.obolibrary.org/obo/HP_0034039		
HP:0034034	biolink:PhenotypicFeature	Differential cyanosis	Differential degree of bluish discoloration between the upper and lower extremities.		hp.json		http://purl.obolibrary.org/obo/HP_0034034		
HP:0010023	biolink:PhenotypicFeature	Small epiphysis of the 1st metacarpal	Abnormally small size of the epiphysis of the 1st metacarpal with respect to age-dependent norms.	UMLS:C4024100	hp.json	Small end part of the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010023		
HP:0034033	biolink:PhenotypicFeature	Peripheral cyanosis	Bluish discoloration of the distal extremities (hands, fingertips, toes), and can sometimes involve circumoral and periorbital areas. Mucous membranes are generally not involved.		hp.json		http://purl.obolibrary.org/obo/HP_0034033		
HP:0010022	biolink:PhenotypicFeature	Pseudoepiphysis of the 1st metacarpal	The epiphysis of the first metacarpal is localized at the proximal end of the metacarpal bone although an accessory epiphysis may be located at the distal end of the metacarpal.	UMLS:C4024101	hp.json		http://purl.obolibrary.org/obo/HP_0010022		
HP:0010021	biolink:PhenotypicFeature	Ivory epiphysis of the 1st metacarpal	The epiphysis of the 1st metacarpal appears hard and dense like ivory. An ivory epiphysis has a uniformly dense appearance on radiographs.	UMLS:C4024102	hp.json	Increased bone density of end part of the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010021		
HP:0034036	biolink:PhenotypicFeature	Pseudo-chilblains on toes	Inflammatory chilblain-like nodules on the feet and/or toes.		hp.json	Chilblain-like toe lesions|Chilblain-like toes|COVID toe	http://purl.obolibrary.org/obo/HP_0034036		
HP:0012680	biolink:PhenotypicFeature	Abnormality of the pineal gland	An anomaly of the pineal gland,a small endocrine gland in the brain that produces melatonin.	UMLS:C4022783	hp.json		http://purl.obolibrary.org/obo/HP_0012680		
HP:0012681	biolink:PhenotypicFeature	Abnormal pineal morphology	A structural abnormality of the pineal gland.	UMLS:C4022782	hp.json	Abnormality of pineal morphology	http://purl.obolibrary.org/obo/HP_0012681		
HP:0034035	biolink:PhenotypicFeature	Pharyngeal exudate	Fluid exuded from the posterior wall of the pharynx.		hp.json	Pharyngeal fluid|Fluid from the pharynx	http://purl.obolibrary.org/obo/HP_0034035		
HP:0010020	biolink:PhenotypicFeature	Irregular epiphysis of the 1st metacarpal	Uneven radiographic opacity of the epiphysis of the 1st metacarpal.	UMLS:C4024103	hp.json	Irregular end part of the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010020		
HP:0000692	biolink:PhenotypicFeature	Tooth malposition	Abnormal alignment, positioning, or spacing of the teeth, i.e., misaligned teeth.	UMLS:C1852504|UMLS:C4280610	hp.json	Teeth, malposition|Abnormal dental position|Malposition of teeth|Abnormality of position of teeth|Abnormality of alignment of teeth|Abnormality of teeth spacing|Malpositioned teeth|Malaligned teeth|Crooked teeth|Misalignment of teeth|Abnormal teeth spacing	http://purl.obolibrary.org/obo/HP_0000692		
HP:0000695	biolink:PhenotypicFeature	Natal tooth	A tooth present at birth or erupting within the first month of life.	UMLS:C0027443|SNOMEDCT_US:58748004|SNOMEDCT_US:21995002|MSH:D009306	hp.json	Teeth present at birth|Natal teeth|Born with teeth|Neonatal teeth	http://purl.obolibrary.org/obo/HP_0000695		hposlim_core
HP:0000694	biolink:PhenotypicFeature	Odontodysplasia	The diagnosis odontodysplasia requires clinical and radiological exams, in which unusually large pulp chambers and large pulp room chambers with thin enamel and dentin are visible. It may affect either a single tooth or several teeth. The term regional odontodysplasia is used if several teeth are affected. It affects the deciduous and permanent dentitions in the maxilla, the mandible or both, although the maxilla is more frequently involved. A type of dental dysplasia occurring in dentinogenesis imperfecta in which the pulp chambers are enlarged and there is a reduced amount of coronal dentin.	SNOMEDCT_US:67504007|UMLS:C2981132	hp.json	Shell teeth|Teeth with dentinal dysplasia|Ghost teeth|Teeth with type iii dentinogenesis imperfecta|Teeth with thin dentin and large pulp chambers	http://purl.obolibrary.org/obo/HP_0000694		
HP:0000696	biolink:PhenotypicFeature	Delayed eruption of permanent teeth	Delayed tooth eruption affecting the secondary dentition.	UMLS:C1849540	hp.json	Delayed eruption of secondary teeth|Delayed eruption of permanent teeth|Delayed eruption of adult teeth|Delayed eruption of secondary dentition|Delayed permanent dentition	http://purl.obolibrary.org/obo/HP_0000696		
HP:0000699	biolink:PhenotypicFeature	Diastema	Increased space between two adjacent teeth in the same dental arch.	UMLS:C0011998|SNOMEDCT_US:35591002|MSH:D003970	hp.json	Gaps between teeth|Dental diastasis|Dental diastema|Gap between teeth|Diastasis of the teeth|Diastema of the teeth	http://purl.obolibrary.org/obo/HP_0000699		hposlim_core
HP:0010029	biolink:PhenotypicFeature	Curved 1st metacarpal	A deviation from the normal straight shape of the first metacarpal.	UMLS:C4024095	hp.json	Curved 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010029		
HP:0000698	biolink:PhenotypicFeature	Conical tooth	An abnormal conical form of the teeth, that is, a tooth whose sides converge or taper together incisally.	UMLS:C4012359|SNOMEDCT_US:29553002|UMLS:C0266037	hp.json	Conical teeth|Peg tooth|Pointed tooth|Conoid tooth|Peg shaped teeth|Peg-shaped teeth|Shark tooth|Cone shaped tooth|Peg shaped tooth	http://purl.obolibrary.org/obo/HP_0000698		hposlim_core
HP:0010028	biolink:PhenotypicFeature	Bullet-shaped 1st metacarpal	The presence of short and wide 1st metacarpal which tapers distally ("bullet shaped").	UMLS:C4024096	hp.json	Bullet-shaped 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010028		
HP:0009027	biolink:PhenotypicFeature	Foot dorsiflexor weakness	Weakness of the muscles responsible for dorsiflexion of the foot, that is, of the movement of the toes towards the shin. The foot dorsiflexors include the tibialis anterior, the extensor hallucis longus, the extensor digitorum longus, and the peroneus tertius muscles.	UMLS:C1866141|UMLS:C0085684|SNOMEDCT_US:6077001	hp.json	Inability to walk on heels|Inability to heel walk|Foot extensor weakness|Footdrop|Foot drop	http://purl.obolibrary.org/obo/HP_0009027		
CHEBI:78840	biolink:ChemicalSubstance	olefinic compound	Any organic molecular entity that contains at least one C=C bond.		hp.json	olefinic compounds	http://purl.obolibrary.org/obo/CHEBI_78840		3_STAR
HP:0009026	biolink:PhenotypicFeature	Hypoplasia of latissimus dorsi muscle	Underdevelopment of the latissimus dorsi muscle, which is involved in adduction, extension, internal rotation, and transverse extension of the shoulder and assists in movement of the scapula.	UMLS:C3805860	hp.json		http://purl.obolibrary.org/obo/HP_0009026		
HP:0009028	biolink:PhenotypicFeature	Generalized weakness of limb muscles	Generalized weakness of the muscles of the arms and legs.	UMLS:C4024605	hp.json	Generalised weakness of limb muscles	http://purl.obolibrary.org/obo/HP_0009028		
HP:0009023	biolink:PhenotypicFeature	Abdominal wall muscle weakness	Decreased strength of the abdominal musculature.	UMLS:C4021527	hp.json	Lax abdominal musculature	http://purl.obolibrary.org/obo/HP_0009023		
HP:0009025	biolink:PhenotypicFeature	Increased connective tissue	The presence of an abnormally increased amount of connective tissue.	UMLS:C1866021	hp.json		http://purl.obolibrary.org/obo/HP_0009025		
HP:0000691	biolink:PhenotypicFeature	Microdontia	Decreased size of the teeth, which can be defined as a mesiodistal tooth diameter (width) more than 2 SD below mean. Alternatively, an apparently decreased maximum width of tooth.	SNOMEDCT_US:32337007|UMLS:C0240340|UMLS:C4280612|UMLS:C4280611	hp.json	Small tooth|Small teeth|Tooth hypoplasia|Underdeveloped tooth|Decreased size of tooth|Decreased width of tooth|Hypotrophic tooth|Tooth hypotrophy	http://purl.obolibrary.org/obo/HP_0000691		hposlim_core
HP:0000690	biolink:PhenotypicFeature	Agenesis of maxillary lateral incisor	Agenesis of one or more maxillary lateral incisor, comprising the maxillary lateral primary incisor and maxillary lateral secondary incisor.	UMLS:C4083046|UMLS:C1849950	hp.json	Absent upper lateral incisors|Absence of maxillary lateral incisor|Absence of upper lateral incisor|Missing maxillary lateral incisor|Failure of development of maxillary lateral incisor|Missing upper lateral incisor	http://purl.obolibrary.org/obo/HP_0000690		
HP:0034041	biolink:PhenotypicFeature	Ventricular ectopy	Ventricular ectopics, also known as ventricular extrasystoles, premature ventricular contractions or complexes (PVC) and ventricular premature depolarisations (VPD) are beats arising from within the ventricles. When they occur in groupings such as bigeminy, trigeminy, couplets and triplets they are referred to as ventricular ectopy.		hp.json		http://purl.obolibrary.org/obo/HP_0034041		
HP:0012671	biolink:PhenotypicFeature	Abulia	Poverty of behavior and speech output, lack of initiative, loss of emotional responses, psychomotor slowing, and prolonged speech latency.	UMLS:C0919974	hp.json	Aboulia	http://purl.obolibrary.org/obo/HP_0012671		
HP:0012672	biolink:PhenotypicFeature	Akinetic mutism	Akinetic mutism is essentially characterized by a total absence of spontaneous behavior and speech occurring in the presence of preserved visual tracking.	SNOMEDCT_US:53333005|MSH:D000405|UMLS:C0001889	hp.json		http://purl.obolibrary.org/obo/HP_0012672		
HP:0034040	biolink:PhenotypicFeature	Bidirectional ventricular tachycardia	Bidirectional ventricular tachycardia (BDVT) is a regular ventricular tachyarrhythmia (VT) with two different QRS morphologies alternating at a rate typically between 140 and 180 bpm.		hp.json		http://purl.obolibrary.org/obo/HP_0034040		
HP:0034043	biolink:PhenotypicFeature	Increased fecal bile acid	Elevated amount of bile acids in the feces.		hp.json		http://purl.obolibrary.org/obo/HP_0034043		
HP:0012673	biolink:PhenotypicFeature	Aplasia of the upper vagina	A failure to develop of the upper vagina.	UMLS:C4022788	hp.json	Absent upper vagina	http://purl.obolibrary.org/obo/HP_0012673		
HP:0012674	biolink:PhenotypicFeature	Aplasia of the lower vagina	A failure to develop of the lower part of the vagina.	SNOMEDCT_US:253834007|UMLS:C0431646	hp.json	Absent lower vagina|Agenesis of the lower vagina	http://purl.obolibrary.org/obo/HP_0012674		
HP:0009042	biolink:PhenotypicFeature	obsolete Marked muscular hypertrophy			hp.json		http://purl.obolibrary.org/obo/HP_0009042		
HP:0034042	biolink:PhenotypicFeature	Dorsal hirsutism	Abnormally increased hair growth in the lskin of the back.		hp.json		http://purl.obolibrary.org/obo/HP_0034042		
HP:0012675	biolink:PhenotypicFeature	Iron accumulation in brain	An abnormal build up of iron (Fe) in brain tissue.	UMLS:C4021076	hp.json	Brain iron deposition|Iron accumulation in brain	http://purl.obolibrary.org/obo/HP_0012675		
HP:0012676	biolink:PhenotypicFeature	Copper accumulation in brain	An anomalous build up of copper (Cu) in the brain.	UMLS:C4022787	hp.json	Copper accumulation in brain|Brain copper accumulation	http://purl.obolibrary.org/obo/HP_0012676		
HP:0012677	biolink:PhenotypicFeature	obsolete Iron accumulation in globus pallidus			hp.json		http://purl.obolibrary.org/obo/HP_0012677		
HP:0012678	biolink:PhenotypicFeature	Iron accumulation in substantia nigra	An anomalous build up of iron (Fe) in the substantia nigra.	UMLS:C4022785	hp.json		http://purl.obolibrary.org/obo/HP_0012678		
HP:0034049	biolink:PhenotypicFeature	Elevated urinary prostaglandin E2 level	An increased amount of prostaglandin E2 in the urine.		hp.json	Elevated urinary PGE2 level	http://purl.obolibrary.org/obo/HP_0034049		
HP:0010016	biolink:PhenotypicFeature	Bracket epiphysis of the 1st metacarpal	An epiphysis that curves around from its transverse orientation to a longitudinal one from proximal to distal along one side of the phalanx, thus resembling the letter 'C' and forming a bracket around the diaphysis. This results in a so called delta phalanx characterized by a triangular or trapezoidal shaped bone with a C-shaped epiphyseal plate.	UMLS:C4024107	hp.json	Bracket shaped end part of 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010016		
CHEBI:66873	biolink:ChemicalSubstance	C4-dicarboxylic acid	Any dicarboxylic acid that contains four carbon atoms.		hp.json	C4-dicarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_66873		3_STAR
HP:0034048	biolink:PhenotypicFeature	Decreased circulating chenodeoxycholic acid concentration	A reduced concentration of chenodeoxycholic acid in the blood circulation.		hp.json	Decreased circulating chenodiol concentration	http://purl.obolibrary.org/obo/HP_0034048		
CHEBI:66874	biolink:ChemicalSubstance	carnosinate	An N-acyl-L-alpha-amino acid anion that is the conjugate base of carnosine, obtained by deprotonation of the carboxy group.	Reaxys:6337985	hp.json	carnosinate anion|carnosinate(1-)|N(alpha)-(beta-alanyl)-L-histidinate|(2S)-2-(beta-alanylamino)-3-(1H-imidazol-4-yl)propanoate	http://purl.obolibrary.org/obo/CHEBI_66874		3_STAR
HP:0010015	biolink:PhenotypicFeature	Absent epiphysis of the 1st metacarpal		UMLS:C4024108	hp.json	Absent end part of the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010015		
HP:0010014	biolink:PhenotypicFeature	Abnormality of the epiphysis of the 1st metacarpal	In contrast to the metacarpals 2-5, the first metacarpal is embryologically of phalangeal origin and as such equivalent to the proximal phalanges of the digits 2-5 (whereas the proximal phalanx of the thumb is equivalent to the middle phalanges of the other digits). The epiphysis of the first metacarpal is localized at the proximal end (as seen in the proximal phalanges of the other digits), whereas the epiphyses of the other metacarpal bones are located at the distal end. This term applies if the epiphysis of the 1st metacarpal is in any way abnormal, referring to age and gender depending norms, as seen on x-rays.	UMLS:C4024109	hp.json	Abnormality of the end part of the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010014		
HP:0010013	biolink:PhenotypicFeature	Abnormal 5th metacarpal morphology	Any abnormality of the fifth metacarpal bone.	UMLS:C4024110	hp.json	Abnormality of the 5th long bone of hand|Abnormality of the 5th metacarpal	http://purl.obolibrary.org/obo/HP_0010013		
HP:0034045	biolink:PhenotypicFeature	Angulated muscle fibers	Normal muscle fibers are polygonal-shaped in cross section, are multinucleated, and have minimal amounts of endomysial connective tissue. In contrast, angulated (also known as angular) muscle fibers have long and narrow vertices (corners) with sharp edges and a pointed tip.		hp.json	Angular muscle fibers	http://purl.obolibrary.org/obo/HP_0034045		
HP:0010012	biolink:PhenotypicFeature	Abnormal 4th metacarpal morphology	Any abnormality of the fourth metacarpal bone.	UMLS:C4024111	hp.json	Abnormality of the 4th long bone of hand|Abnormality of the 4th metacarpal	http://purl.obolibrary.org/obo/HP_0010012		
HP:0010011	biolink:PhenotypicFeature	Abnormal 3rd metacarpal morphology	Any abnormality of the third metacarpal bone.	UMLS:C4024112	hp.json	Abnormality of the 3rd metacarpal|Abnormality of the 3rd long bone of hand	http://purl.obolibrary.org/obo/HP_0010011		
HP:0034044	biolink:PhenotypicFeature	Trident pelvis	Spurs at the medial and lateral acetabular margin and in the center of the acetabulum gives rise to shape resembling a three-pronged spear known as trident.		hp.json	Trident sign	http://purl.obolibrary.org/obo/HP_0034044		
HP:0034047	biolink:PhenotypicFeature	Rib osteolysis	Osteolysis (destruction of bone through bone resorption with removal or loss of calcium) localized to a rib.		hp.json		http://purl.obolibrary.org/obo/HP_0034047		
HP:0010010	biolink:PhenotypicFeature	Abnormal 2nd metacarpal morphology	Any abnormality of the second metacarpal bone.	UMLS:C4024113	hp.json	Abnormality of the 2nd long bone of hand|Abnormality of the 2nd metacarpal	http://purl.obolibrary.org/obo/HP_0010010		
HP:0034046	biolink:PhenotypicFeature	Mandibular osteolysis	Osteolysis (destruction of bone through bone resorption with removal or loss of calcium) localized to the mandible.		hp.json		http://purl.obolibrary.org/obo/HP_0034046		
HP:0012670	biolink:PhenotypicFeature	Orthostatic syncope	Syncope following a quick change in position from lying down to standing.	UMLS:C0749201	hp.json		http://purl.obolibrary.org/obo/HP_0012670		
HP:0010019	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the 1st metacarpal	Epiphysis of the 1st metacarpal having multiple bony fragments.	UMLS:C4024104	hp.json	Fragmentation of the end part of the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010019		
HP:0010018	biolink:PhenotypicFeature	Enlarged epiphysis of the 1st metacarpal	Abnormally large size of the epiphyses of the 1st metacarpal with respect to age-dependent norms.	UMLS:C4024105	hp.json	Enlarged end part of the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010018		
HP:0010017	biolink:PhenotypicFeature	Cone-shaped epiphysis of the 1st metacarpal	A cone-shaped appearance of the epiphysis of the 1st metacarpal, producing a 'ball-in-a-socket' appearance.	UMLS:C4024106	hp.json	Cone-shaped end part of the 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0010017		
HP:0012679	biolink:PhenotypicFeature	Widened interpedicular distance	An increase in the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces.	UMLS:C4022784	hp.json		http://purl.obolibrary.org/obo/HP_0012679		
HP:0009037	biolink:PhenotypicFeature	Segmental spinal muscular atrophy		UMLS:C1866774|MSH:C566670	hp.json		http://purl.obolibrary.org/obo/HP_0009037		
HP:0010085	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the proximal phalanx of the hallux		UMLS:C4024061	hp.json	Absent/small innermost big toe bone|Absent/underdeveloped innermost big toe bone	http://purl.obolibrary.org/obo/HP_0010085		
HP:0010084	biolink:PhenotypicFeature	Duplication of the distal phalanx of the hallux		UMLS:C4021339	hp.json	Duplication of the outermost bone of big toe|Partial/complete duplication of the distal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010084		
HP:0010083	biolink:PhenotypicFeature	Triangular shaped distal phalanx of the hallux		UMLS:C4024062	hp.json	Triangular shaped outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010083		
HP:0009098	biolink:PhenotypicFeature	Chronic oral candidiasis	Chronic accumulation and overgrowth of the fungus Candida albicans on the mucous membranes of the mouth, generally manifested as associated with creamy white lesions on the tongue or inner cheeks, occasionally spreading to the gums, tonsils, palate or oropharynx.	UMLS:C4024599	hp.json	Chronic oral thrush	http://purl.obolibrary.org/obo/HP_0009098		
HP:0010082	biolink:PhenotypicFeature	Symphalangism affecting the distal phalanx of the hallux		UMLS:C4024063	hp.json	Fused outermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010082		
CHEBI:76206	biolink:ChemicalSubstance	xenobiotic metabolite	Any metabolite produced by metabolism of a xenobiotic compound.		hp.json	xenobiotic metabolites	http://purl.obolibrary.org/obo/CHEBI_76206		3_STAR
HP:0010081	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the hallux		UMLS:C4024064	hp.json	Uneven increase in bone density in the outermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010081		
HP:0009092	biolink:PhenotypicFeature	Progressive alveolar ridge hypertropy		UMLS:C4280407|UMLS:C1854934	hp.json	Progressive hypertrophy of alveolar process of jaw|Increasing overgrowth of gum ridge|Increasing size of gum ridge	http://purl.obolibrary.org/obo/HP_0009092		
HP:0010080	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanx of the hallux		UMLS:C4024065	hp.json		http://purl.obolibrary.org/obo/HP_0010080		
HP:0009094	biolink:PhenotypicFeature	Cleft lower alveolar ridge		UMLS:C4280406|UMLS:C4280405|UMLS:C1849350|UMLS:C4280404	hp.json	Notch of lower gum ridge|Notch of mandibular alveolar ridge|Cleft of lower gum ridge|Notch of lower alveolar ridge|Notch of mandibular alveolar process|Cleft of lower alveolar process|Cleft of mandibular alveolar process|Cleft of lower gingiva|Cleft of mandibular gingiva|Notch of lower alveolar process	http://purl.obolibrary.org/obo/HP_0009094		
CHEBI:66884	biolink:ChemicalSubstance	N-alkylglycine zwitterion	An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of any N-alkylglycine; major species at pH 7.3.	MetaCyc:N-Alkylglycine|PMID:9989229	hp.json	an N-alkylglycine	http://purl.obolibrary.org/obo/CHEBI_66884		3_STAR
HP:0009090	biolink:PhenotypicFeature	obsolete Facial diplegic appearance			hp.json		http://purl.obolibrary.org/obo/HP_0009090		
HP:0010089	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanx of the hallux		UMLS:C4024058	hp.json		http://purl.obolibrary.org/obo/HP_0010089		
HP:0010088	biolink:PhenotypicFeature	Curved proximal phalanx of the hallux	A deviation from the normal straight form of the proximal phalanx of the big toe.	UMLS:C4024059	hp.json	Curved innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010088		
HP:0010087	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the hallux	An abnormal morphology of the proximal phalanx of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4024060	hp.json	Bullet-shaped innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010087		
HP:0010086	biolink:PhenotypicFeature	Broad proximal phalanx of the hallux	Increased width of proximal phalanx of big toe.	UMLS:C4021338	hp.json	Broad innermost bone of the big toe|Broad proximal phalanx of the big toe	http://purl.obolibrary.org/obo/HP_0010086		
HP:0009088	biolink:PhenotypicFeature	Speech articulation difficulties	Impairment in the physical production of speech sounds.	UMLS:C1865313	hp.json		http://purl.obolibrary.org/obo/HP_0009088		
HP:0010074	biolink:PhenotypicFeature	Triangular shaped 1st metatarsal		UMLS:C4024070	hp.json	Triangular shaped 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010074		
HP:0010073	biolink:PhenotypicFeature	Synostosis involving the 1st metatarsal		UMLS:C4024071	hp.json	Fusion involving the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010073		
HP:0010072	biolink:PhenotypicFeature	Patchy sclerosis of the 1st metatarsal		UMLS:C4024072	hp.json	Uneven increase in bone density of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010072		
HP:0010071	biolink:PhenotypicFeature	Osteolytic defects of the 1st metatarsal	Dissolution or degeneration of bone tissue of the first metatarsal.	UMLS:C4024073	hp.json		http://purl.obolibrary.org/obo/HP_0010071		
HP:0010070	biolink:PhenotypicFeature	Curved 1st metatarsal	A deviation from the normal straight shape of a proximal phalanx of the 1st metatarsal bone.	UMLS:C4024074	hp.json	Curved 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010070		
HP:0010079	biolink:PhenotypicFeature	Curved distal phalanx of the hallux	A deviation from the normal straight form of the distal phalanx of the big toe.	UMLS:C4024066	hp.json	Curved outermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010079		
HP:0010078	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the hallux	An abnormal morphology of the distal phalanx of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4024067	hp.json	Bullet-shaped outermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010078		
HP:0010077	biolink:PhenotypicFeature	Broad distal phalanx of the hallux	An increase in width of the distal phalanx of the big toe.	UMLS:C4024068	hp.json	Wide outermost bone of big toe|Broad outermost bone of big toe	http://purl.obolibrary.org/obo/HP_0010077		
HP:0010076	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the hallux		UMLS:C4024069	hp.json	Absent/underdeveloped outermost big toe bone|Absent/small outermost big toe bone	http://purl.obolibrary.org/obo/HP_0010076		
UBERON:6000137	biolink:AnatomicalEntity	embryonic tagma	Any tagma (UBERON:6000002) that is part of some embryo (UBERON:6000052).	FBbt:00000137	hp.json		http://purl.obolibrary.org/obo/UBERON_6000137		
HP:0010075	biolink:PhenotypicFeature	Duplication of the 1st metatarsal	A developmental defect consisting in the duplication of the first metatarsal bone.	UMLS:C1851855	hp.json	Duplicated first metatarsals|Duplicated 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010075		
HP:0009099	biolink:PhenotypicFeature	Median cleft palate	Cleft palate of the midline of the palate.	UMLS:C1850968	hp.json	Central cleft palate|Midline cleft palate	http://purl.obolibrary.org/obo/HP_0009099		
HP:0010063	biolink:PhenotypicFeature	Patchy sclerosis of hallux phalanx	Patchy (irregular) increase in bone density of one or more phalanges of the big toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4021340	hp.json	Patchy sclerosis of the phalanges of the hallux|Uneven increase in bone density in big toe bone	http://purl.obolibrary.org/obo/HP_0010063		
HP:0009073	biolink:PhenotypicFeature	Progressive proximal muscle weakness	Lack of strength of the proximal muscles that becomes progressively more severe.	UMLS:C1836156	hp.json	Muscle weakness, progressive, proximal	http://purl.obolibrary.org/obo/HP_0009073		
HP:0010062	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the hallux		UMLS:C4024078	hp.json		http://purl.obolibrary.org/obo/HP_0010062		
HP:0010061	biolink:PhenotypicFeature	Curved hallux phalanx	A deviation from the normal straight form of one or more phalanges of the big toe.	UMLS:C4021341	hp.json	Curved phalanges of the hallux|Curve bones of big toe	http://purl.obolibrary.org/obo/HP_0010061		
HP:0010060	biolink:PhenotypicFeature	Bullet-shaped hallux phalanx	An abnormal morphology of one or more phalanges of the big toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4021342	hp.json	Bullet-shaped phalanges of the hallux|Bullet-shaped bone of big toe	http://purl.obolibrary.org/obo/HP_0010060		
HP:0009072	biolink:PhenotypicFeature	Decreased Achilles reflex	Decreased intensity of the Achilles reflex (also known as the ankle jerk reflex), which can be elicited by tapping the tendon is tapped while the foot is dorsiflexed.	UMLS:C1837323	hp.json	Hyporeflexia at ankle joints	http://purl.obolibrary.org/obo/HP_0009072		
HP:0009071	biolink:PhenotypicFeature	Inflammatory myopathy	Chronic muscle inflammation accompanied by muscle weakness.	MSH:D009220|UMLS:C0027121|SNOMEDCT_US:26889001|SNOMEDCT_US:128496001	hp.json		http://purl.obolibrary.org/obo/HP_0009071		
HP:0010069	biolink:PhenotypicFeature	Bullet-shaped 1st metatarsal	An abnormal morphology of the firstmetatarsal bone, which is short and wide and tapers distally, and lacks the normal diaphyseal constriction.	UMLS:C4024075	hp.json	Bullet-shaped 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010069		
HP:0010068	biolink:PhenotypicFeature	Broad first metatarsal	Increased side-to-side width of the first metatarsal bone.	UMLS:C1855899	hp.json	Wide 1st long bone of foot|Enlarged first metatarsal|Broad 1st metatarsal	http://purl.obolibrary.org/obo/HP_0010068		
HP:0010067	biolink:PhenotypicFeature	Aplasia/hypoplasia of the 1st metatarsal	Absence or underdevelopment of the first metatarsal bone.	UMLS:C4024076	hp.json	Absent/small 1st long bone of foot|Absent/underdeveloped 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010067		
HP:0010066	biolink:PhenotypicFeature	Duplication of phalanx of hallux	Partial or complete duplication of one or more phalanx of big toe.	UMLS:C4020691|UMLS:C1860164	hp.json	Duplicated hallux|Partial/complete duplication of the phalanges of the hallux|Hallucal duplication|Duplication of phalanx of big toe|Duplication of big toe bone|Duplication of great toes	http://purl.obolibrary.org/obo/HP_0010066		
HP:0010065	biolink:PhenotypicFeature	Triangular shaped phalanges of the hallux		UMLS:C4024077	hp.json	Triangular shaped bones of big toe	http://purl.obolibrary.org/obo/HP_0010065		
HP:0010064	biolink:PhenotypicFeature	Symphalangism affecting the phalanges of the hallux		UMLS:C1836216	hp.json	Fused big toe bones|hallucal symphalangism	http://purl.obolibrary.org/obo/HP_0010064		
CHEBI:52290	biolink:ChemicalSubstance	mitogen	A chemical substance that encourages a cell to commence cell division, triggering mitosis.		hp.json	mitogens	http://purl.obolibrary.org/obo/CHEBI_52290		3_STAR
HP:0009067	biolink:PhenotypicFeature	Progressive spinal muscular atrophy	Progressive spinal muscular atrophy, i.e., muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem.	UMLS:C4082951	hp.json	Progressive spinal muscle degeneration|Progressive spinal muscle wasting	http://purl.obolibrary.org/obo/HP_0009067		
HP:0009069	biolink:PhenotypicFeature	Lethal infantile mitochondrial myopathy		UMLS:C1838876|MSH:C564017	hp.json		http://purl.obolibrary.org/obo/HP_0009069		
HP:0009085	biolink:PhenotypicFeature	Alveolar ridge overgrowth	Increased width of the alveolar ridges.	UMLS:C1856164|UMLS:C1865598	hp.json	Thickened alveolar ridges|Increased size of alveolar ridge|Hypertrophied alveolar ridge|Hyperplasia of alveolar process of jaw|Increased size of gum ridge|Thick alveolar ridges|Overgrowth of gum ridge|Alveolar ridge excess|Enlarged alveolar ridge|Overgrowth of alveolar ridge|Hyperplasia of alveolar ridge	http://purl.obolibrary.org/obo/HP_0009085		hposlim_core
HP:0010052	biolink:PhenotypicFeature	Abnormal morphology of the proximal phalanx of the hallux	An abnormal shape or form of the proximal phalanx of the big toe.	UMLS:C4024084	hp.json	Abnormal innermost big toe bone|Abnormality of the proximal phalanx of the hallux	http://purl.obolibrary.org/obo/HP_0010052		
HP:0010051	biolink:PhenotypicFeature	Deviation of the hallux	Displacement of the big toe from its normal position.	UMLS:C4021344	hp.json	Displacement of the hallux|Displacement of big toe	http://purl.obolibrary.org/obo/HP_0010051		
HP:0009084	biolink:PhenotypicFeature	Midline notch of upper alveolar ridge		UMLS:C1851853	hp.json	Midline cleft of maxillary alveolar process|Midline notch of maxillary alveolar process|Midline cleft of upper alveolar ridge|Midline notch of upper gum ridge|Midline notch of maxillary alveolar ridge	http://purl.obolibrary.org/obo/HP_0009084		
HP:0009087	biolink:PhenotypicFeature	Posteriorly placed tongue		UMLS:C4024600	hp.json	Posteriorly placed tongue	http://purl.obolibrary.org/obo/HP_0009087		
HP:0034005	biolink:PhenotypicFeature	Decreased dendritic spine number	An abnormal reduction in the amount of spines on a given dendrite.		hp.json		http://purl.obolibrary.org/obo/HP_0034005		
HP:0010059	biolink:PhenotypicFeature	Broad hallux phalanx	An increase in width in one or more phalanges of the big toe.	UMLS:C4021343	hp.json	Broad phalanges of the hallux|Wide bone of big toe|Broad bone of big toe	http://purl.obolibrary.org/obo/HP_0010059		
HP:0034004	biolink:PhenotypicFeature	Parosmia	Misperception of existing odor, that is, distorted or altered olfactory perception in the presence of known stimuli.		hp.json		http://purl.obolibrary.org/obo/HP_0034004		
HP:0010058	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the phalanges of the hallux		UMLS:C4024079	hp.json	Absent/small big toe bone|Absent/underdeveloped big toe bone	http://purl.obolibrary.org/obo/HP_0010058		
HP:0034007	biolink:PhenotypicFeature	Posterior atrophy of corpus callosum	The presence of atrophy (wasting) of the posterior portion of the corpus callosum.		hp.json		http://purl.obolibrary.org/obo/HP_0034007		
HP:0034006	biolink:PhenotypicFeature	Decreased urinary lysyl-pyridinoline-hydroxylysyl-pyridinoline ratio	A decreased amount of the urinary cross-links lysyl-pyridinoline (LP, or deoxypyridinoline DPD) as compared to hydroxylysyl-pyridinoline (HP, or pyridinoline PYD). Both are established biochemical markers of osteoclastic bone resorption and collagen degradation.		hp.json		http://purl.obolibrary.org/obo/HP_0034006		
HP:0010057	biolink:PhenotypicFeature	Abnormal hallux phalanx morphology		UMLS:C4024080	hp.json	Abnormality of the phalanges of the hallux|Abnormal big toe bones	http://purl.obolibrary.org/obo/HP_0010057		
HP:0010056	biolink:PhenotypicFeature	Abnormality of the epiphyses of the hallux		UMLS:C4024081	hp.json	Abnormality of the end part of the big toe bone	http://purl.obolibrary.org/obo/HP_0010056		
HP:0034001	biolink:PhenotypicFeature	Anti-Complement factor H antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against complement factor H.		hp.json	CFH autoantibodies	http://purl.obolibrary.org/obo/HP_0034001		
HP:0010055	biolink:PhenotypicFeature	Broad hallux	Visible increase in width of the hallux without an increase in the dorso-ventral dimension.	UMLS:C1867131	hp.json	Broad halluces|Broad great toes|Broad great toe|Wide big toe|Abnormally broad great toes|Broad big toe	http://purl.obolibrary.org/obo/HP_0010055		hposlim_core
HP:0034000	biolink:PhenotypicFeature	Tracheal hemorrhage	Tracheal hemorrhage is a focal bleeding within the trachea. It be diagnosed by tracheobronchoscopy.		hp.json	Tracheal bleeding	http://purl.obolibrary.org/obo/HP_0034000		
HP:0034003	biolink:PhenotypicFeature	Broad medial eyebrow	Regional increase in the width (height) of the middle portion of the eyebrow.		hp.json	Medial broadening of eyebrows	http://purl.obolibrary.org/obo/HP_0034003		
HP:0010054	biolink:PhenotypicFeature	Abnormality of the first metatarsal bone	An anomaly of the first metatarsal bone.	UMLS:C4024082	hp.json	Abnormality of the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0010054		
HP:0034002	biolink:PhenotypicFeature	Anti-phospholipase A2 receptor antibody positivity	The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the phospholipase A2 receptor.		hp.json	Anti-PLA2R antibody positivity	http://purl.obolibrary.org/obo/HP_0034002		
HP:0010053	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the hallux		UMLS:C4024083	hp.json	Abnormality of the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0010053		
CHEBI:545959	biolink:ChemicalSubstance	homovanillic acid	A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.	KEGG:C05582|CAS:306-08-1|PMID:8353435|CAS:306-08-1|PMID:24007816|MetaCyc:CPD-7651|KNApSAcK:C00029504|PMID:24423636|Wikipedia:Homovanillic_acid|PMID:14688447|PMID:24416192|HMDB:HMDB0000118|Reaxys:2213447	hp.json	2-(4-hydroxy-3-methoxyphenyl)acetic acid|Vanillacetic acid|Homovanillic acid|3-Methoxy-4-hydroxyphenylacetate|(4-hydroxy-3-methoxyphenyl)acetic acid|4-Hydroxy-3-methoxybenzeneacetic acid|3-Methoxy-4-hydroxyphenylacetic acid|HVA	http://purl.obolibrary.org/obo/CHEBI_545959		3_STAR
HP:0034009	biolink:PhenotypicFeature	Pelvic lipomatosis	Overgrowth of fat in the perivesical and perirectal area.		hp.json		http://purl.obolibrary.org/obo/HP_0034009		
HP:0034008	biolink:PhenotypicFeature	Opto-chiasmatic atrophy	Wasting (atrophy) of the optic chiasm.		hp.json		http://purl.obolibrary.org/obo/HP_0034008		
HP:0009077	biolink:PhenotypicFeature	Weakness of long finger extensor muscles		UMLS:C4024601	hp.json		http://purl.obolibrary.org/obo/HP_0009077		
GO:0062094	biolink:BiologicalProcess	stomach development	The process whose specific outcome is the progression of the stomach over time, from its formation to the mature structure. The stomach is an expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ.		hp.json		http://purl.obolibrary.org/obo/GO_0062094		
CHEBI:30807	biolink:ChemicalSubstance	tetradecanoate	A long-chain fatty acid anion that is the conjugate base of myristic acid; major species at pH 7.3.	Reaxys:3589340|Gmelin:335122|Beilstein:3589340|KEGG:C06424	hp.json	n-tetradecan-1-oate|myristate|Tetradecanoate|1-tetradecanecarboxylate|tetradecanoate|tetradecoate|n-tetradecoate|tetradecanoate|CH3-[CH2]12-COO(-)	http://purl.obolibrary.org/obo/CHEBI_30807		3_STAR
CHEBI:17822	biolink:ChemicalSubstance	serine	An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	Reaxys:1721402|Beilstein:1721402|Wikipedia:Serine|CAS:302-84-1|Gmelin:26429|KNApSAcK:C00001393|CAS:302-84-1|CAS:302-84-1|KEGG:C00716	hp.json	2-Amino-3-hydroxypropionic acid|2-amino-3-hydroxypropanoic acid|serine|Serine|3-Hydroxyalanine|Serin	http://purl.obolibrary.org/obo/CHEBI_17822		3_STAR
CHEBI:17823	biolink:ChemicalSubstance	calcitriol	A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.	DrugBank:DB00136|Wikipedia:Calcitriol|PMID:20599255|MetaCyc:CALCITRIOL|PDBeChem:VDX|PMID:10217585|KEGG:D00129|LIPID_MAPS_instance:LMST03020258|PMID:15928596|PMID:6687801|PMID:23144765|PMID:19429426|KEGG:C01673|PMID:22905919|Drug_Central:466|CAS:32222-06-3|Reaxys:2227647|Beilstein:2227647|CAS:32222-06-3|PMID:23103122	hp.json	Rocaltrol|1alpha,25-dihydroxyvitamin D3|calcitriol|1-alpha-25-Dihydroxyvitamin D3|1alpha,25-dihydroxycholecalciferol|Decostriol|5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL|Calcitriol|calcitriol|(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol|(1alpha,3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol|calcitriolum|1,25-DHCC|calcitriol|1alpha,25(OH)2D3|Calcijex|(5Z,7E)-(1S,3R)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol|(1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol	http://purl.obolibrary.org/obo/CHEBI_17823		3_STAR
HP:0000403	biolink:PhenotypicFeature	Recurrent otitis media	Increased susceptibility to otitis media, as manifested by recurrent episodes of otitis media.	UMLS:C0747085	hp.json	Recurrent middle ear infection|Multiple episodes of otitis media|Susceptibility to otitis media|Recurrent episodes of otitis media|Otitis media, recurrent|Frequent otitis media	http://purl.obolibrary.org/obo/HP_0000403		
HP:0000405	biolink:PhenotypicFeature	Conductive hearing impairment	An abnormality of vibrational conductance of sound to the inner ear leading to impairment of sensory perception of sound.	MSH:D006314|UMLS:C0018777|SNOMEDCT_US:44057004	hp.json	Conductive deafness|Conduction deafness|Hearing loss, conductive|Conductive hearing loss	http://purl.obolibrary.org/obo/HP_0000405		hposlim_core
UBERON:0010498	biolink:AnatomicalEntity	pseudostratified columnar epithelium	A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels.	UMLS:C1514590|FMA:45572|NCIT:C49316|UMLS:C0836138|Wikipedia:Pseudostratified_columnar_epithelium|NCIT:C33419	hp.json		http://purl.obolibrary.org/obo/UBERON_0010498		
HP:0000408	biolink:PhenotypicFeature	Progressive sensorineural hearing impairment	A progressive form of sensorineural hearing impairment.	UMLS:C1843156	hp.json	Hearing loss, sensorineural, progressive|Sensorineural hearing loss, progressive|Bilateral progressive sensorineural hearing loss|Hearing loss, progressive sensorineural|Progressive bilateral sensorineural hearing loss|Hearing loss, sensorineural, bilateral, progressive	http://purl.obolibrary.org/obo/HP_0000408		
HP:0000407	biolink:PhenotypicFeature	Sensorineural hearing impairment	A type of hearing impairment in one or both ears related to an abnormal functionality of the cochlear nerve.	SNOMEDCT_US:60700002|UMLS:C0018784|MSH:D006319	hp.json	Sensorineural hearing loss|Sensorineural deafness|Hearing loss, sensorineural	http://purl.obolibrary.org/obo/HP_0000407		hposlim_core
UBERON:0010499	biolink:AnatomicalEntity	pseudostratified ciliated columnar epithelium	Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile.	FMA:13146|UMLS:C0506992|NCIT:C13181	hp.json	epithelium pseudostratificatum columnare ciliatum (trachea et bronchi)	http://purl.obolibrary.org/obo/UBERON_0010499		
HP:0000400	biolink:PhenotypicFeature	Macrotia	Median longitudinal ear length greater than two standard deviations above the mean and median ear width greater than two standard deviations above the mean (objective); or, apparent increase in length and width of the pinna (subjective).	UMLS:C1848570|SNOMEDCT_US:69056000|UMLS:C1850189|UMLS:C0554972|UMLS:C1860838|SNOMEDCT_US:275480001|UMLS:C1855062|UMLS:C1835581|UMLS:C0152421	hp.json	Large ears|Large pinnae	http://purl.obolibrary.org/obo/HP_0000400		hposlim_core
HP:0000402	biolink:PhenotypicFeature	Stenosis of the external auditory canal	An abnormal narrowing of the external auditory canal.	SNOMEDCT_US:300127002|SNOMEDCT_US:301061006|UMLS:C0576860|UMLS:C0395837	hp.json	Narrow external auditory meatus|Narrow external auditory canals|External auditory canal stenosis|Narrow ear canal|Narrow auditory canals|Narrowing of passageway from outer ear to middle ear|Stenotic external auditory canal	http://purl.obolibrary.org/obo/HP_0000402		hposlim_core
UBERON:0009494	biolink:AnatomicalEntity	pharyngeal arch mesenchymal region	A portion of mesenchymal tissue associated with an individual pharyngeal arch.	FMA:295694|EMAPA:32755	hp.json	pharyngeal arch mesenchyme|branchial arch mesenchyme|pharyngeal arch mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009494		pheno_slim
UBERON:0009497	biolink:AnatomicalEntity	epithelium of foregut-midgut junction	An epithelium that is part of a foregut-midgut junction.	EHDAA2:0000573|EMAPA:16564	hp.json		http://purl.obolibrary.org/obo/UBERON_0009497		emapa_ehdaa2
GO:0086070	biolink:BiologicalProcess	SA node cell to atrial cardiac muscle cell communication	The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.		hp.json	sinoatrial node cardiomyocyte to atrial cardiomyocyte communication|SA node cardiomyocyte to atrial cardiomyocyte communication|SA node cardiac muscle cell to atrial cardiac muscle cell communication|sinus node cardiomyocyte to atrial cardiomyocyte communication|SAN cardiomyocyte to atrial cardiomyocyte communication	http://purl.obolibrary.org/obo/GO_0086070		
UBERON:0009480	biolink:AnatomicalEntity	endoderm of buccopharyngeal membrane	An endoderm that is part of a buccopharyngeal membrane.	EHDAA2:0000191|EMAPA:16261	hp.json		http://purl.obolibrary.org/obo/UBERON_0009480		emapa_ehdaa2
UBERON:0009482	biolink:AnatomicalEntity	associated mesenchyme of foregut-midgut junction	Mesenchyme that is part of a foregut-midgut junction.	EHDAA2:0000570|EMAPA:16364	hp.json		http://purl.obolibrary.org/obo/UBERON_0009482		emapa_ehdaa2
BSPO:0015101	biolink:NamedThing	in dorsal side of	X dorsal side of Y <=> if Y is subdivided into two dorsal and ventral portions, X is part of the dorsal portion.	BSPO:0015101	hp.json		http://purl.obolibrary.org/obo/BSPO_0015101		
BSPO:0015102	biolink:NamedThing	in ventral side of	X ventral side of Y <=> if Y is subdivided into two dorsal and ventral portions, X is part of the ventral portion.	BSPO:0015102	hp.json		http://purl.obolibrary.org/obo/BSPO_0015102		
GO:0086068	biolink:BiologicalProcess	Purkinje myocyte to ventricular cardiac muscle cell communication	The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.		hp.json		http://purl.obolibrary.org/obo/GO_0086068		
GO:0086067	biolink:BiologicalProcess	AV node cell to bundle of His cell communication	The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.		hp.json	atrioventricular node cell to bundle of His cell communication	http://purl.obolibrary.org/obo/GO_0086067		
GO:0086065	biolink:BiologicalProcess	cell communication involved in cardiac conduction	Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.		hp.json		http://purl.obolibrary.org/obo/GO_0086065		
UBERON:0009483	biolink:AnatomicalEntity	mesentery of foregut-midgut junction	A mesentery that is part of a foregut-midgut junction.	VHOG:0000430|EMAPA:16365|EHDAA2:0000575	hp.json	foregut-midgut junction mesentery	http://purl.obolibrary.org/obo/UBERON_0009483		emapa_ehdaa2
HP:0012420	biolink:PhenotypicFeature	Meconium stained amniotic fluid	Amniotic fluid containing the earliest stools of a mammalian infant.	UMLS:C0426209|SNOMEDCT_US:168092006|SNOMEDCT_US:249135009	hp.json	Meconium-stained amniotic fluid|Meconium staining of amniotic fluid	http://purl.obolibrary.org/obo/HP_0012420		
HP:0012421	biolink:PhenotypicFeature	Congenital absence of foreskin	Congenital lack of the skin of prepuce of penis, that is, of the double-layered fold of skin and mucous membrane that covers the glans penis.	UMLS:C0577242|SNOMEDCT_US:300519001	hp.json	Absent foreskin|Aposthia	http://purl.obolibrary.org/obo/HP_0012421		
HP:0012422	biolink:PhenotypicFeature	Villous hypertrophy of choroid plexus	Overgrowth of the choroid plexus.	UMLS:C4021089|UMLS:C4020728	hp.json	Diffuse villous hypertrophy of choroid plexus|Choroid plexus hypertrophy	http://purl.obolibrary.org/obo/HP_0012422		
HP:0012423	biolink:PhenotypicFeature	Colonic inertia	The inability of the colon to modify stool to an acceptable consistency and move the stool from the cecum to the rectosigmoid area at least once every three days.	UMLS:C1257861|MSH:D003248	hp.json		http://purl.obolibrary.org/obo/HP_0012423		
HP:0012424	biolink:PhenotypicFeature	Chorioretinitis	An inflammation of the choroid and retina.	UMLS:C0008513|MSH:D002825|SNOMEDCT_US:46627006	hp.json		http://purl.obolibrary.org/obo/HP_0012424		
HP:0012425	biolink:PhenotypicFeature	Stercoral ulcer	An ulcer of the colon due to pressure and irritation from retained fecal masses.	SNOMEDCT_US:38084005|UMLS:C0267491|SNOMEDCT_US:46040000|UMLS:C0333302|SNOMEDCT_US:235766003	hp.json	Colon ulcer|Recto-sigmoid colon stercoral ulcer	http://purl.obolibrary.org/obo/HP_0012425		
HP:0000437	biolink:PhenotypicFeature	Depressed nasal tip	Decreased distance from the nasal tip to the nasal base.	UMLS:C1859717	hp.json	Caved in nasal tip|Nasal tip, retruded|Flat tip of nose|Flat nasal tip|Retruded tip of nose|Flattened nasal tip|Depressed tip of nose|Nasal tip, recessed|Depressed nasal tip|Nasal tip, depressed	http://purl.obolibrary.org/obo/HP_0000437		hposlim_core
HP:0000436	biolink:PhenotypicFeature	Abnormality of the nasal tip	An abnormality of the nasal tip.	UMLS:C4025852	hp.json	Deformity of the nasal tip|Malformation of the nasal tip|Deformity of tip of nose|Malformation of tip of nose|Abnormality of tip of nose|Abnormality of the nasal tip	http://purl.obolibrary.org/obo/HP_0000436		hposlim_core
HP:0000431	biolink:PhenotypicFeature	Wide nasal bridge	Increased breadth of the nasal bridge (and with it, the nasal root).	SNOMEDCT_US:249321001|UMLS:C1839764|UMLS:C1849367	hp.json	Nasal bridge broad|Increased width of nasal bridge|Nasal bridge, wide|Increased breadth of bridge of nose|Broad flat nasal bridge|Broad nasal bridge|Wide nasal bridge|Increased width of bridge of nose|Increased breadth of nasal bridge|Broad nasal root|Broadened nasal bridge|Widened nasal bridge|Wide bridge of nose	http://purl.obolibrary.org/obo/HP_0000431		
HP:0000430	biolink:PhenotypicFeature	Underdeveloped nasal alae	Thinned, deficient, or excessively arched ala nasi.	UMLS:C1834055	hp.json	Hypoplastic alar cartilage|Small nasal alae|Hypoplastic nasal alae|Hypoplastic nasal wings|Hypoplastic alae nasae|Thin hypoplastic alae nasi|Decreased size of nasal alae|Hypoplastic nostrils|Hypoplastic alar nasae|Nasal cartilage hypoplasia|Alar cartilage hypoplasia|Hypoplastic nares|Underdeveloped tissue around nostril|Ala nasi, underdeveloped|Hypoplastic alae nasi	http://purl.obolibrary.org/obo/HP_0000430		hposlim_core
HP:0000433	biolink:PhenotypicFeature	Abnormal nasal mucosa morphology		UMLS:C4025854	hp.json	Abnormality of mucous membrane of nose|Abnormality of nasal mucous membrane|Abnormality of mucosa of nose|Abnormality of the nasal mucosa	http://purl.obolibrary.org/obo/HP_0000433		
HP:0000434	biolink:PhenotypicFeature	Nasal mucosa telangiectasia	Telangiectasia of the nasal mucosa.	UMLS:C4025853	hp.json	Spider veins of mucous membrane of nose|Telangiectasia of mucous membrane of nose|Spider veins of nasal mucous membrane|Telangiectasia of nasal mucous membrane|Telangiectasia of mucosa of nose|Nasal mucous membrane telangiectasia|Spider veins of mucosa of nose|Angioectasia of mucosa of nose|Angioectasia of mucous membrane of nose|Angioectasia of nasal mucous membrane	http://purl.obolibrary.org/obo/HP_0000434		
HP:0012426	biolink:PhenotypicFeature	Optic disc drusen	Optic disc drusen are acellular, calcified deposits within the optic nerve head. Optic disc drusen are congenital and developmental anomalies of the optic nerve head, representing hyaline-containing bodies that, over time, appear as elevated, lumpy irregularities on the anterior portion of the optic nerve.	MSH:D015594|UMLS:C0029128|SNOMEDCT_US:33629003	hp.json	Optic nerve head drusen	http://purl.obolibrary.org/obo/HP_0012426		
HP:0012427	biolink:PhenotypicFeature	Increased femoral anteversion	An increased degree of femoral version, which is defined as the angular difference between axis of femoral neck and transcondylar axis of the knee. Thus, femoral anteversion is an inward twisting of the femur that causes the knees and feet to turn inward.	UMLS:C4022909	hp.json	Increased femoral neck anteversion|Excessive femoral anteversion|Internally rotated hips	http://purl.obolibrary.org/obo/HP_0012427		
HP:0012428	biolink:PhenotypicFeature	Prominent calcaneus	Protruding heel bone, or calcaneus.	UMLS:C4021088	hp.json	Prominent heel bone	http://purl.obolibrary.org/obo/HP_0012428		
HP:0012429	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the cerebral white matter	Absence or underdevelopment of the cerebral white matter.	UMLS:C4021844	hp.json	Absent/underdeveloped cerebral white matter|Absent/small cerebral white matter	http://purl.obolibrary.org/obo/HP_0012429		
HP:0012410	biolink:PhenotypicFeature	Pure red cell aplasia	A type of anemia resulting from suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production. Erythroblasts are virtually absent in bone marrow; however, leukocyte and platelet production show little or no reduction.	UMLS:C0034902|MSH:D012010|SNOMEDCT_US:50715003	hp.json	Red cell aplasia	http://purl.obolibrary.org/obo/HP_0012410		
HP:0012411	biolink:PhenotypicFeature	Premature pubarche	The onset of growth of pubic hair at an earlier age than normal.	UMLS:C0342541|SNOMEDCT_US:237815000	hp.json	Premature pubic hair growth	http://purl.obolibrary.org/obo/HP_0012411		
HP:0012412	biolink:PhenotypicFeature	Premature adrenarche	Onset of adrenarche at an earlier age than usual.	SNOMEDCT_US:103021001|UMLS:C0342546	hp.json		http://purl.obolibrary.org/obo/HP_0012412		
HP:0012413	biolink:PhenotypicFeature	Notched primary central incisor	The presence of a V-shaped indentation (notch) in the primary central incisor.	UMLS:C0020186|MSH:D013590|SNOMEDCT_US:86443005|UMLS:C4022912|UMLS:C1444627|SNOMEDCT_US:410500004	hp.json	Notched front deciduous tooth|Notched front baby tooth|Notched front primary tooth|Syphilitic primary incisor	http://purl.obolibrary.org/obo/HP_0012413		
HP:0012414	biolink:PhenotypicFeature	Duodenal atrophy	Wasting or decrease in size of all or part of the duodenum.	UMLS:C4022911	hp.json		http://purl.obolibrary.org/obo/HP_0012414		
HP:0000448	biolink:PhenotypicFeature	Prominent nose	Distance between subnasale and pronasale more than two standard deviations above the mean, or alternatively, an apparently increased anterior protrusion of the nasal tip.	UMLS:C0426415|SNOMEDCT_US:249311009|UMLS:C4280629|UMLS:C1400105	hp.json	Disproportionately large nose|Prominent nose|Hyperplasia of nose|Increased size of nose|Nasal hyperplasia|Pronounced nose|Large nose|Hypertrophy of nose|Increased nasal size|Nasal hypertrophy|Big nose	http://purl.obolibrary.org/obo/HP_0000448		hposlim_core
HP:0000447	biolink:PhenotypicFeature	Pear-shaped nose		UMLS:C1853482	hp.json	Pear-shaped nose	http://purl.obolibrary.org/obo/HP_0000447		
HP:0000444	biolink:PhenotypicFeature	Convex nasal ridge	Nasal ridge curving anteriorly to an imaginary line that connects the nasal root and tip. The nose appears often also prominent, and the columella low.	UMLS:C0240538	hp.json	Hooked nose|Convex dorsum of nose|Beaklike protrusion|Polly beak nasal deformity|Beaked nose|Convex nasal dorsum	http://purl.obolibrary.org/obo/HP_0000444		hposlim_core
HP:0000446	biolink:PhenotypicFeature	Narrow nasal bridge	Decreased width of the bony bridge of the nose.	UMLS:C4551564	hp.json	Pinched nasal bridge|Nasal Bridge, Narrow|Nasal bridge, thin|Narrow bridge of nose|Pinched bridge of nose|Narrow nasal root|Narrow nasal bridge	http://purl.obolibrary.org/obo/HP_0000446		hposlim_core
HP:0000445	biolink:PhenotypicFeature	Wide nose	Interalar distance more than two standard deviations above the mean for age, i.e., an apparently increased width of the nasal base and alae.	UMLS:C0426421|SNOMEDCT_US:249321001	hp.json	Broad nose|Wide nose|Increased breadth of nose|Increased nasal breadth|Increased width of nose|Increased nasal width	http://purl.obolibrary.org/obo/HP_0000445		hposlim_core
HP:0012415	biolink:PhenotypicFeature	Abnormal blood gas level	An abnormality of the partial pressure of oxygen or carbon dioxide in the arterial blood.	SNOMEDCT_US:312391003|UMLS:C0476337	hp.json	Abnormal blood gas level	http://purl.obolibrary.org/obo/HP_0012415		
HP:0012416	biolink:PhenotypicFeature	Hypercapnia	Abnormally elevated blood carbon dioxide (CO2) level.	UMLS:C0020440|SNOMEDCT_US:29596007|MSH:D006935	hp.json	High blood carbon dioxide level|Hypercarbia	http://purl.obolibrary.org/obo/HP_0012416		
HP:0012417	biolink:PhenotypicFeature	Hypocapnia	Abnormally reduced blood carbon dioxide (CO2) level.	SNOMEDCT_US:61031008|UMLS:C0085383|MSH:D016857	hp.json	Reduced carbon dioxide in the blood|Hypocarbia	http://purl.obolibrary.org/obo/HP_0012417		
HP:0012418	biolink:PhenotypicFeature	Hypoxemia	An abnormally low level of blood oxygen.	UMLS:C0700292|SNOMEDCT_US:389087006|MSH:D000860	hp.json	Hypoxia|Low blood oxygen level	http://purl.obolibrary.org/obo/HP_0012418		
HP:0012419	biolink:PhenotypicFeature	Hyperoxemia	An abnormally high level of blood oxygen.	UMLS:C4022910	hp.json		http://purl.obolibrary.org/obo/HP_0012419		
CHEBI:78804	biolink:ChemicalSubstance	Caenorhabditis elegans metabolite	A nematode metabolite produced by Caenorhabditis elegans.		hp.json	C. elegans metabolites|Caenorhabditis elegans metabolites|C. elegans metabolite	http://purl.obolibrary.org/obo/CHEBI_78804		3_STAR
CHEBI:78803	biolink:ChemicalSubstance	nematode metabolite	An animal metabolite produced by any member of the phylum Nematoda.		hp.json	nematode metabolites	http://purl.obolibrary.org/obo/CHEBI_78803		3_STAR
HP:0012400	biolink:PhenotypicFeature	Abnormal aldolase level	An abnormal concentration of aldolase in the serum. Aldolase is an enzyme responsible for converting fructose 1,6-bisphosphate into the triose phosphates dihydroxyacetone phosphate and glyceraldehyde 3-phosphate.	UMLS:C4022916	hp.json		http://purl.obolibrary.org/obo/HP_0012400		
HP:0012401	biolink:PhenotypicFeature	Abnormal urine alpha-ketoglutarate concentration	A deviation from normal of the concentration of 2-oxoglutaric acid in the urine.	UMLS:C4020902	hp.json	Abnormal urinary 2-oxoglutarate level|Abnormality of urine alpha ketoglutarate concentration	http://purl.obolibrary.org/obo/HP_0012401		
HP:0012402	biolink:PhenotypicFeature	Increased urine alpha-ketoglutarate concentration	A greater than normal concentration of 2-oxoglutaric acid in the urine.	UMLS:C4022915	hp.json	Elevated urinary 2-oxoglutarate|Increased urine alpha-ketoglutarate concentration	http://purl.obolibrary.org/obo/HP_0012402		
HP:0012403	biolink:PhenotypicFeature	Decreased urine alpha-ketoglutarate concentration	A lower than normal concentration of 2-oxoglutaric acid in the urine.	UMLS:C4022914	hp.json	Decreased urinary 2-oxoglutarate	http://purl.obolibrary.org/obo/HP_0012403		
HP:0000415	biolink:PhenotypicFeature	Abnormality of the choanae	Abnormality of the choanae (the posterior nasal apertures).	UMLS:C4025855	hp.json		http://purl.obolibrary.org/obo/HP_0000415		
HP:0000414	biolink:PhenotypicFeature	Bulbous nose	Increased volume and globular shape of the anteroinferior aspect of the nose.	UMLS:C1834118|UMLS:C1855751|MSH:C538354|UMLS:C0240543	hp.json	Bulbous nose|Bulbous nasal tip|Potato nose	http://purl.obolibrary.org/obo/HP_0000414		
HP:0000417	biolink:PhenotypicFeature	Slender nose		UMLS:C1857645	hp.json	Slender nose	http://purl.obolibrary.org/obo/HP_0000417		
HP:0000419	biolink:PhenotypicFeature	Abnormality of the nasal septum	An abnormality of the nasal septum.	SNOMEDCT_US:95433000|UMLS:C0151790	hp.json	Anomaly of septum of nose|Anomaly of nasal septum|Abnormality of the nasal septum|Abnormality of septum of nose	http://purl.obolibrary.org/obo/HP_0000419		hposlim_core
HP:0000418	biolink:PhenotypicFeature	Narrow nasal ridge	Decreased width of the nasal ridge.	UMLS:C1837761	hp.json	Thin nasal dorsum|Narrow nasal dorsum|Decreased width of nasal dorsum|Decreased width of nasal ridge|Narrow nasal ridge|Thin dorsum of nose|Thin nasal ridge|Narrow dorsum of nose|Decreased width of dorsum of nose|Pinched nose	http://purl.obolibrary.org/obo/HP_0000418		
HP:0000411	biolink:PhenotypicFeature	Protruding ear	Angle formed by the plane of the ear and the mastoid bone greater than the 97th centile for age (objective); or, outer edge of the helix more than 2 cm from the mastoid at the point of maximum distance (objective).	UMLS:C1305420|UMLS:C1855285|SNOMEDCT_US:275478007	hp.json	Prominent ear|Protruding ears|Prominent ears	http://purl.obolibrary.org/obo/HP_0000411		
HP:0000410	biolink:PhenotypicFeature	Mixed hearing impairment	A type of hearing loss resulting from a combination of conductive hearing impairment and sensorineural hearing impairment.	UMLS:C0155552|SNOMEDCT_US:77507001|MSH:D046089	hp.json	Mixed hearing loss|Hearing loss, mixed|Mixed hearing impairment	http://purl.obolibrary.org/obo/HP_0000410		
HP:0000413	biolink:PhenotypicFeature	Atresia of the external auditory canal	Absence or failure to form of the external auditory canal.	UMLS:C1866190|UMLS:C1857079|UMLS:C1398325|UMLS:C1840305	hp.json	Auditory canal atresia|External auditory meatal atresia|External acoustic meatus atresia|Absent auditory canals|Atretic auditory canals|Atretic external auditory canal|Absent ear canal|Atresia of the external auditory canals|Atretic external auditory canals|External auditory canal atresia|Absent external auditory canals|External auditory meatus atresia|Atretic auditory canal	http://purl.obolibrary.org/obo/HP_0000413		hposlim_core
HP:0012404	biolink:PhenotypicFeature	Abnormal urine citrate concentration	A deviation from normal of the concentration of citrate(3-) in the urine.	UMLS:C4022913	hp.json	Abnormal urine citrate concentration|Abnormal urine citric acid concentration	http://purl.obolibrary.org/obo/HP_0012404		
HP:0012405	biolink:PhenotypicFeature	Hypocitraturia	A lower than normal concentration of citrate(3-) in the urine.	UMLS:C2673444	hp.json	Decreased urine citrate concentration	http://purl.obolibrary.org/obo/HP_0012405		
HP:0012406	biolink:PhenotypicFeature	Hypercitraturia	A greater than normal concentration of citrate(3-) in the urine.	UMLS:C4021090	hp.json	Increased urine citrate concentration	http://purl.obolibrary.org/obo/HP_0012406		
HP:0012407	biolink:PhenotypicFeature	Scissor gait	A type of spastic paraparetic gait in which the muscle tone in the adductors is marked. It is characterized by hypertonia and flexion in the legs, hips and pelvis accompanied by extreme adduction leading to the knees and thighs hitting, or sometimes even crossing, in a scissors-like movement. The opposing muscles (abductors) become comparatively weak from lack of use.	UMLS:C0231698|SNOMEDCT_US:22090007|MSH:D020233	hp.json	Scissor walk|Scissor gait|Scissors gait	http://purl.obolibrary.org/obo/HP_0012407		
HP:0012408	biolink:PhenotypicFeature	Medullary nephrocalcinosis	The deposition of calcium salts in the parenchyma of the renal medulla (innermost part of the kidney).	SNOMEDCT_US:236447005|UMLS:C0403477	hp.json		http://purl.obolibrary.org/obo/HP_0012408		
HP:0012409	biolink:PhenotypicFeature	Cortical nephrocalcinosis	The deposition of calcium salts in the parenchyma of the renal cortex (the outer portion of the kidney between the renal capsule and the renal medulla).	SNOMEDCT_US:236446001|UMLS:C0403476	hp.json		http://purl.obolibrary.org/obo/HP_0012409		
HP:0000426	biolink:PhenotypicFeature	Prominent nasal bridge	Anterior positioning of the nasal root in comparison to the usual positioning for age.	UMLS:C1854113|UMLS:C4230640	hp.json	Elevated nasal bridge|Convex nasal bridge|Prominent nasal root|Prominent bridge of nose|Protruding bridge of nose|High nasal bridge|Convex bridge of nose|Prominent nasal bridge|Protruding nasal bridge	http://purl.obolibrary.org/obo/HP_0000426		
HP:0000429	biolink:PhenotypicFeature	Abnormality of the nasal alae	An abnormality of the Ala of nose.	UMLS:C4021804|UMLS:C4280632|UMLS:C4280631|UMLS:C2227020	hp.json	Deformity of the nasal alar cartilage|Malformation of the nasal alar cartilage|Abnormality of the nasal alar cartilage|Abnormality of the nasal ala|Deformity of the nasal ala|Malformation of the nasal ala	http://purl.obolibrary.org/obo/HP_0000429		hposlim_core
HP:0000420	biolink:PhenotypicFeature	Short nasal septum	Reduced superior to inferior length of the nasal septum.	UMLS:C1844857	hp.json	Short septum of nose|Decreased length of nasal septum|Short nasal septum|Decreased length of septum of nose	http://purl.obolibrary.org/obo/HP_0000420		hposlim_core
HP:0000422	biolink:PhenotypicFeature	Abnormal nasal bridge morphology	Abnormality of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi.	UMLS:C4021805	hp.json	Abnormality of the bridge of the nose|Abnormality of the nasal root|Abnormality of the nasal bridge|Malformation of the bridge of the nose|Deformity of the bridge of the nose|Deformity of the nasal bridge|Malformation of the nasal bridge	http://purl.obolibrary.org/obo/HP_0000422		hposlim_core
HP:0000421	biolink:PhenotypicFeature	Epistaxis	Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose.	ICD10:R04.0|SNOMEDCT_US:12441001|EFO:0003895|SNOMEDCT_US:249366005|UMLS:C0014591|ICD9:784.7|MSH:D004844|COHD:318556|NCIT:C26766	hp.json	Nose bleed|Frequent nosebleeds|Nasal hemorrhage|Nasal haemorrhage|Nosebleed|Nose bleeding|Bloody nose	http://purl.obolibrary.org/obo/HP_0000421		
CL:0000765	biolink:Cell	erythroblast	A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.	BTO:0001571|CALOHA:TS-0289|FMA:83504	hp.json	normoblast	http://purl.obolibrary.org/obo/CL_0000765		
CL:0000766	biolink:Cell	myeloid leukocyte	A cell of the monocyte, granulocyte, or mast cell lineage.		hp.json		http://purl.obolibrary.org/obo/CL_0000766		
CL:0000767	biolink:Cell	basophil	Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.	BTO:0000129|CALOHA:TS-0073|FMA:62862	hp.json	basophilic leukocyte|polymorphonuclear leucocyte|basophilic leucocyte|polymorphonuclear leukocyte	http://purl.obolibrary.org/obo/CL_0000767		
UBERON:0010421	biolink:AnatomicalEntity	spleen B cell corona	The area of the (spleen) secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes.	EMAPA:37962	hp.json	B cell domain of the spleen|spleen lymphocytic corona|splenic B cell corona|spleen B-cell corona|spleen B cell corona|splenic corona|spleen mantle zone|follicle mantle|B lymphocyte domain of the spleen|lymphocytic corona	http://purl.obolibrary.org/obo/UBERON_0010421		pheno_slim|human_reference_atlas
UBERON:0010422	biolink:AnatomicalEntity	primary nodular lymphoid tissue	A lymphoid follicle containing naive B cells.	FMA:55223	hp.json	primary lymphoid follicle|primary lymphoid nodule|primary follicle	http://purl.obolibrary.org/obo/UBERON_0010422		
GO:0062013	biolink:BiologicalProcess	positive regulation of small molecule metabolic process	Any process that activates or increases the frequency, rate or extent of a small molecule metabolic process.		hp.json	positive regulation of small molecule metabolism	http://purl.obolibrary.org/obo/GO_0062013		
UBERON:0010420	biolink:AnatomicalEntity	lymph node germinal center mantle zone	A part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it.	MA:0002990|EMAPA:37661	hp.json	lymph node follicular mantle|lymph node follicular corona|germinal center mantle zone|mantle zone of lymph node germinal center|lymph node inactive zone|lymph node dark zone|lymph node peripheral zone|mantle zone of germinal center|lymph node B cell corona	http://purl.obolibrary.org/obo/UBERON_0010420		pheno_slim|human_reference_atlas
GO:0062012	biolink:BiologicalProcess	regulation of small molecule metabolic process	Any process that modulates the rate, frequency or extent of a small molecule metabolic process.		hp.json	regulation of small molecule metabolism	http://purl.obolibrary.org/obo/GO_0062012		
GO:0062014	biolink:BiologicalProcess	negative regulation of small molecule metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of a small molecule metabolic process.		hp.json	negative regulation of small molecule metabolism	http://purl.obolibrary.org/obo/GO_0062014		
UBERON:0010412	biolink:AnatomicalEntity	epididymal fat pad	Encapsulated adipose tissue associated with the epididymis.	MA:0002550|EMAPA:35316	hp.json	periepididymal fat pad	http://purl.obolibrary.org/obo/UBERON_0010412		pheno_slim
UBERON:0010418	biolink:AnatomicalEntity	urethral opening	An orifice that is part of a lower urinary tract.	MA:0002867|EMAPA:35965	hp.json	urethral orifice	http://purl.obolibrary.org/obo/UBERON_0010418		pheno_slim
CL:0000763	biolink:Cell	myeloid cell	A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.	CALOHA:TS-0647|BTO:0001441	hp.json		http://purl.obolibrary.org/obo/CL_0000763		
UBERON:0010416	biolink:AnatomicalEntity	lymph node B cell domain	A part of the lymph node cortex in which B lymphocytes home to primary follicles to survey follicular dendritic cells (FDCs); antigen stimulated B cells proliferate and differentiate within the follicles forming distinctive germinal centers.	MA:0002851	hp.json	nodular lymph node cortex|lymph node B-cell domain|lymph node B cell dependent cortex	http://purl.obolibrary.org/obo/UBERON_0010416		pheno_slim
UBERON:0010417	biolink:AnatomicalEntity	lymph node T cell domain	The paracortex and interfollicular cortex of the lymph node in which T lymphocytes home to survey dendritic cells.	MA:0002852|EMAPA:37663	hp.json	T cell zone of lymph node|lymph node T zone|T zone of lymph node|lymph node T-cell domain|lymph node deep cortex|lymph node T cell dependent paracortex	http://purl.obolibrary.org/obo/UBERON_0010417		pheno_slim
CL:0000764	biolink:Cell	erythroid lineage cell	A immature or mature cell in the lineage leading to and including erythrocytes.	CALOHA:TS-0290|FMA:83516|FMA:62845	hp.json	erythropoietic cell	http://purl.obolibrary.org/obo/CL_0000764		
GO:0003723	biolink:MolecularActivity	RNA binding	Binding to an RNA molecule or a portion thereof.	Reactome:R-HSA-203922	hp.json	base pairing with RNA|poly-A RNA binding|poly(A)-RNA binding|poly(A) RNA binding	http://purl.obolibrary.org/obo/GO_0003723		goslim_plant|goslim_flybase_ribbon|goslim_drosophila|goslim_aspergillus|goslim_chembl|goslim_mouse|goslim_yeast|goslim_candida|goslim_agr|goslim_generic
CHEBI:27247	biolink:ChemicalSubstance	urocanate	An monocarboxylic acid anion that is the conjugate base of urocanic acid.	MetaCyc:UROCANATE|KEGG:C00785|ECMDB:ECMDB21396	hp.json	3-(1H-imidazol-4-yl)prop-2-enoate|urocanate	http://purl.obolibrary.org/obo/CHEBI_27247		3_STAR
CHEBI:88184	biolink:ChemicalSubstance	metal allergen	Any metal which causes the onset of an allergic reaction.		hp.json	allergenic metal|allergenic metals|metal allergens	http://purl.obolibrary.org/obo/CHEBI_88184		3_STAR
CHEBI:27248	biolink:ChemicalSubstance	urocanic acid	An alpha,beta-unsaturated monocarboxylic acid that is prop-2-enoic acid substituted by a 1H-imidazol-4-yl group at position 3. It is a metabolite of hidtidine.	HMDB:HMDB0000301|PMID:11669511|MetaCyc:UROCANATE|Beilstein:8128219|Wikipedia:Urocanic_acid|Reaxys:8128219|ECMDB:ECMDB21396|CAS:104-98-3|PMID:24397532|PMID:24627570|PDBeChem:URO	hp.json	3-(1H-imidazol-4-yl)-2-propenoic acid|3-imidazol-4-ylacrylic acid|3-(1H-imidazol-4-yl)prop-2-enoic acid	http://purl.obolibrary.org/obo/CHEBI_27248		3_STAR
CHEBI:88188	biolink:ChemicalSubstance	drug allergen	Any drug which causes the onset of an allergic reaction.		hp.json	allergenic drug	http://purl.obolibrary.org/obo/CHEBI_88188		3_STAR
CL:0000778	biolink:Cell	mononuclear osteoclast	A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts.		hp.json		http://purl.obolibrary.org/obo/CL_0000778		
CL:0000779	biolink:Cell	multinuclear osteoclast	A specialized multinuclear osteoclast associated with the absorption and removal of bone.		hp.json	multinucleated osteoclast	http://purl.obolibrary.org/obo/CL_0000779		
UBERON:0010411	biolink:AnatomicalEntity	retroperitoneal fat pad	Encapsulated adipose tissue found on the dorsal side of the peritoneum.	MA:0002549	hp.json	retroperitoneal fat depot	http://purl.obolibrary.org/obo/UBERON_0010411		pheno_slim
UBERON:0010402	biolink:AnatomicalEntity	epidermis suprabasal layer	Any layer of the epidermis that is superior to the stratum basale.	MA:0000808|EMAPA:35315	hp.json	suprabasal layer|suprabasal layer of epidermis|suprabasal cell layer of skin	http://purl.obolibrary.org/obo/UBERON_0010402		pheno_slim
CL:0000771	biolink:Cell	eosinophil	Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive.	FMA:62861|BTO:0000399|CALOHA:TS-0279	hp.json	eosinocyte|polymorphonuclear leucocyte|eosinophilic leucocyte|polymorphonuclear leukocyte|eosinophilic granulocyte|eosinophilic leukocyte	http://purl.obolibrary.org/obo/CL_0000771		
UBERON:0010408	biolink:AnatomicalEntity	ocular angle artery	The angular artery is the terminal part of the facial artery; it ascends to the medial angle of the eye's orbit, imbedded in the fibers of the angular head of the Quadratus labii superioris, and accompanied by the angular vein.	UMLS:C0226116|FMA:49583|MA:0002010|NCIT:C32076|EMAPA:37673	hp.json	angular artery	http://purl.obolibrary.org/obo/UBERON_0010408		human_reference_atlas
CL:0000775	biolink:Cell	neutrophil	Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.	FMA:62860|CALOHA:TS-0688|BTO:0000130	hp.json	polynuclear neutrophilic leukocyte|neutrocyte|polymorphonuclear leucocyte|neutrophilic leucocyte|PMN|neutrophil leukocyte|polynuclear neutrophilic leucocyte|poly|polymorphonuclear neutrophil|neutrophilic leukocyte|polymorphonuclear leukocyte|neutrophil leucocyte	http://purl.obolibrary.org/obo/CL_0000775		
UBERON:0010409	biolink:AnatomicalEntity	ocular surface region	The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms.	EMAPA:35336|MA:0002486	hp.json	ocular surface|eye surface|eye surface region	http://purl.obolibrary.org/obo/UBERON_0010409		pheno_slim
CHEBI:17893	biolink:ChemicalSubstance	(2R)-2-hydroxy monocarboxylic acid	A 2-hydroxy monocarboxylic acid having (2R)-configuration.	KEGG:C02489|KEGG:C15487	hp.json	(2R)-2-hydroxy monocarboxylic acids|(R)-2-Hydroxyacid|(R)-2-Hydroxycarboxylic acid|(2R)-Hydroxy-carboxylate	http://purl.obolibrary.org/obo/CHEBI_17893		3_STAR
CHEBI:17891	biolink:ChemicalSubstance	donor	A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity.	KEGG:C01351	hp.json	Donor|Donator|donneur	http://purl.obolibrary.org/obo/CHEBI_17891		3_STAR
CHEBI:27216	biolink:ChemicalSubstance	urate(2-)			hp.json	urate dianion	http://purl.obolibrary.org/obo/CHEBI_27216		3_STAR
CL:0000745	biolink:Cell	retina horizontal cell	A neuron that laterally connects other neurons in the inner nuclear layer of the retina.	BTO:0004120	hp.json	horizontal cell	http://purl.obolibrary.org/obo/CL_0000745		
CL:0000746	biolink:Cell	cardiac muscle cell	Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.	FMA:14067|BTO:0001539|CALOHA:TS-0115	hp.json	cardiocyte|cardiac muscle fiber|heart muscle cell|cardiac myocyte|cardiomyocyte	http://purl.obolibrary.org/obo/CL_0000746		
GO:1904457	biolink:BiologicalProcess	positive regulation of neuronal action potential	Any process that activates or increases the frequency, rate or extent of neuronal action potential.		hp.json	activation of neuronal action potential|positive regulation of generation of action potential|up regulation of generation of action potential|upregulation of neuronal action potential|up-regulation of generation of action potential|up-regulation of neuronal action potential|activation of generation of action potential|upregulation of generation of action potential|up regulation of neuronal action potential	http://purl.obolibrary.org/obo/GO_1904457		
GO:0062033	biolink:BiologicalProcess	positive regulation of mitotic sister chromatid segregation	Any process that starts or increases the frequency, rate or extent of sister chromatid segregation during mitosis.		hp.json		http://purl.obolibrary.org/obo/GO_0062033		
CL:0000748	biolink:Cell	retinal bipolar neuron	A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer.		hp.json		http://purl.obolibrary.org/obo/CL_0000748		
UBERON:0010400	biolink:AnatomicalEntity	spleen trabecular vein	One of the veins that feed the splenic vein.	MA:0000760|NCIT:C49779|UMLS:C1710160	hp.json	trabecular vein	http://purl.obolibrary.org/obo/UBERON_0010400		pheno_slim|human_reference_atlas
GO:1904456	biolink:BiologicalProcess	negative regulation of neuronal action potential	Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential.		hp.json	inhibition of generation of action potential|down-regulation of neuronal action potential|downregulation of generation of action potential|down regulation of neuronal action potential|inhibition of neuronal action potential|down regulation of generation of action potential|downregulation of neuronal action potential|down-regulation of generation of action potential|negative regulation of generation of action potential	http://purl.obolibrary.org/obo/GO_1904456		
CL:0000740	biolink:Cell	retinal ganglion cell	The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.	BTO:0001800|FMA:67765	hp.json	RGC|ganglion cell of retina|gangliocyte	http://purl.obolibrary.org/obo/CL_0000740		
CL:4028001	biolink:Cell	pulmonary capillary endothelial cell	Any capillary endothelial cell that is part of a lung.		hp.json	lung capillary endothelial cell	http://purl.obolibrary.org/obo/CL_4028001		
CHEBI:30861	biolink:ChemicalSubstance	methylmalonate(1-)	A dicarboxylic acid monoanion resulting from the removal of a proton from one of the carboxylic acid groups of methylmalonic acid.	Beilstein:5499681|Reaxys:5499681|Gmelin:142213	hp.json	2-carboxypropanoate	http://purl.obolibrary.org/obo/CHEBI_30861		3_STAR
CHEBI:30860	biolink:ChemicalSubstance	methylmalonic acid	A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.	PMID:15770414|CAS:516-05-2|KEGG:C02170|Gmelin:50008|PMID:22233538|CAS:516-05-2|PMID:22104738|PMID:22422209|PMID:22332180|CAS:516-05-2|LIPID_MAPS_instance:LMFA01170118|PMID:22770225|PMID:21802231|MetaCyc:CPD-546|PMID:21652239|PMID:22377700|PMID:22301932|PMID:11673368|PMID:22537172|PDBeChem:DXX|PMID:17190852|PMID:22509143|PMID:21687976|Wikipedia:Methylmalonic_acid|PMID:22424943|Beilstein:1756084|PMID:21896502|Reaxys:1756084|DrugBank:DB04183|PMID:21748409|PMID:21478039|HMDB:HMDB0000202	hp.json	methylpropanedioic acid|2-methylmalonic acid|Isosuccinic acid|alpha-methylmalonic acid|Methylmalonic acid|METHYLMALONIC ACID|1,1-Ethanedicarboxylic acid	http://purl.obolibrary.org/obo/CHEBI_30860		3_STAR
CHEBI:30879	biolink:ChemicalSubstance	alcohol	A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom.	KEGG:C00069	hp.json	an alcohol|Alcohol|alcohols	http://purl.obolibrary.org/obo/CHEBI_30879		3_STAR
CHEBI:29888	biolink:ChemicalSubstance	diphosphoric acid	An acyclic phosphorus acid anhydride obtained by condensation of two molecules of phosphoric acid.	DrugBank:DB04160|ECMDB:ECMDB04142|Gmelin:82619|KNApSAcK:C00019561|CAS:2466-09-3|PMID:6291941|CAS:2466-09-3|CAS:2466-09-3|Reaxys:3942075|PDBeChem:PPV|KEGG:C00013	hp.json	H4P2O7|[(HO)2P(O)OP(O)(OH)2]|Diphosphoric acid|Pyrophosphate|mu-oxido-bis(dihydroxidooxidophosphorus)|Pyrophosphorsaeure|1,5-dihydrido-2,4-dihydroxido-2,4-dioxido-1,3,5-trioxy-2,4-diphosphy-[5]catena|Pyrophosphoric acid|Diphosphorsaeure|acide diphosphorique|PYROPHOSPHATE|diphosphoric acid	http://purl.obolibrary.org/obo/CHEBI_29888		3_STAR
CHEBI:27226	biolink:ChemicalSubstance	uric acid	An oxopurine that is the final oxidation product of purine metabolism.	HMDB:HMDB0000289|Wikipedia:Uric_acid	hp.json	uric acids	http://purl.obolibrary.org/obo/CHEBI_27226		3_STAR
NCBITaxon:3312	biolink:OrganismalEntity	Coniferophyta		GC_ID:1	hp.json	conifers	http://purl.obolibrary.org/obo/NCBITaxon_3312		
GO:0062023	biolink:CellularComponent	collagen-containing extracellular matrix	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.		hp.json		http://purl.obolibrary.org/obo/GO_0062023		
GO:0003707	biolink:MolecularActivity	nuclear steroid receptor activity	Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.		hp.json	steroid hormone receptor activity	http://purl.obolibrary.org/obo/GO_0003707		
CHEBI:30848	biolink:ChemicalSubstance	urate(1-)		CAS:3106-08-9	hp.json	uric acid, ion(1-)|uric acid monoanion|7,9-dihydro-1H-purine-2,6,8(3H)-trione, ion(1-)	http://purl.obolibrary.org/obo/CHEBI_30848		3_STAR
HGNC:1437	biolink:Gene	CALCA (human)	A protein coding gene CALCA in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=1437		
UBERON:0009471	biolink:AnatomicalEntity	dorsum of tongue	The superior surface of the tongue divided by the sulcus terminalis into an anterior two-thirds, the presulcal part (pars presulcalis). and a posterior one-third, the postsulcal part (pars postsulcalis).	UMLS:C0226952|NCIT:C32482|FMA:54651|SCTID:66938003	hp.json	dorsum linguae|dorsum linguae|tongue dorsum|dorsal tongue	http://purl.obolibrary.org/obo/UBERON_0009471		
CL:0000723	biolink:Cell	somatic stem cell	A stem cell that can give rise to cell types of the body other than those of the germ-line.	CALOHA:TS-2086|FMA:63368	hp.json		http://purl.obolibrary.org/obo/CL_0000723		
GO:0086019	biolink:BiologicalProcess	cell-cell signaling involved in cardiac conduction	Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.		hp.json	cell-cell signalling involved in cardiac conduction	http://purl.obolibrary.org/obo/GO_0086019		
GO:1904479	biolink:BiologicalProcess	negative regulation of intestinal absorption	Any process that stops, prevents or reduces the frequency, rate or extent of intestinal absorption.		hp.json	down regulation of intestinal absorption|downregulation of intestinal absorption|inhibition of intestinal absorption|down-regulation of intestinal absorption	http://purl.obolibrary.org/obo/GO_1904479		
GO:0086018	biolink:BiologicalProcess	SA node cell to atrial cardiac muscle cell signaling	Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.		hp.json	sinoatrial node cardiomyocyte to atrial cardiomyocyte signalling|sinus node cardiomyocyte to atrial cardiomyocyte signalling|SAN cardiomyocyte to atrial cardiomyocyte signalling|SA node cardiac muscle cell to atrial cardiac muscle cell signalling|SA node cardiomyocyte to atrial cardiomyocyte signalling	http://purl.obolibrary.org/obo/GO_0086018		
GO:1904478	biolink:BiologicalProcess	regulation of intestinal absorption	Any process that modulates the frequency, rate or extent of intestinal absorption.		hp.json		http://purl.obolibrary.org/obo/GO_1904478		
GO:0086017	biolink:BiologicalProcess	Purkinje myocyte action potential	An action potential that occurs in a Purkinje myocyte.		hp.json		http://purl.obolibrary.org/obo/GO_0086017		
GO:0086016	biolink:BiologicalProcess	AV node cell action potential	An action potential that occurs in an atrioventricular node cardiac muscle cell.		hp.json	atrioventricular node cardiac muscle cell action potential|AV node cardiac muscle cell action potential	http://purl.obolibrary.org/obo/GO_0086016		
GO:0086015	biolink:BiologicalProcess	SA node cell action potential	An action potential that occurs in a sinoatrial node cardiac muscle cell.		hp.json	SA node cardiac muscle cell action potential|sinoatrial node cardiac muscle cell action potential|sinus node cardiac muscle cell action potential|SAN cardiac muscle cell action potential	http://purl.obolibrary.org/obo/GO_0086015		
GO:1904484	biolink:BiologicalProcess	cloacal gland development	The process whose specific outcome is the progression of a cloacal gland over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_1904484		
GO:1904480	biolink:BiologicalProcess	positive regulation of intestinal absorption	Any process that activates or increases the frequency, rate or extent of intestinal absorption.		hp.json	up-regulation of intestinal absorption|up regulation of intestinal absorption|activation of intestinal absorption|upregulation of intestinal absorption	http://purl.obolibrary.org/obo/GO_1904480		
UBERON:0009472	biolink:AnatomicalEntity	axilla	The axilla is the area directly under the joint where the forelimb connects to the shoulder.	NCIT:C12674|MESH:D001365|CALOHA:TS-2208|UMLS:C0004454|FMA:24864|EFO:0001395|galen:Axilla	hp.json	axillary region|axillary region|arm pit|oxter|regio axillaris|axillae|armpit|armpits|underarm|axilla	http://purl.obolibrary.org/obo/UBERON_0009472		pheno_slim|efo_slim
UBERON:0009477	biolink:AnatomicalEntity	associated mesenchyme of otic placode	Mesenchyme that is part of a otic placode.	EMAPA:16196|EHDAA2:0001340	hp.json		http://purl.obolibrary.org/obo/UBERON_0009477		emapa_ehdaa2
UBERON:0009479	biolink:AnatomicalEntity	ectoderm of buccopharyngeal membrane	An ectoderm that is part of a buccopharyngeal membrane.	EMAPA:16260|EHDAA2:0000190	hp.json		http://purl.obolibrary.org/obo/UBERON_0009479		emapa_ehdaa2
CHEBI:27207	biolink:ChemicalSubstance	univalent carboacyl group	A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid.		hp.json	univalent acyl group|univalent carboxylic acyl groups|univalent carboacyl groups	http://purl.obolibrary.org/obo/CHEBI_27207		3_STAR
CHEBI:27208	biolink:ChemicalSubstance	unsaturated fatty acid	Any fatty acid containing at least one C=C or C#C bond.	LIPID_MAPS_class:LMFA0103|PMID:5322381	hp.json	alkene acid|olefinic acid|unsaturated fatty acids|unsaturated fatty acids	http://purl.obolibrary.org/obo/CHEBI_27208		3_STAR
CL:0000737	biolink:Cell	striated muscle cell	Muscle cell which has as its direct parts myofilaments organized into sarcomeres.	CALOHA:TS-2157|BTO:0002916|FMA:86936	hp.json		http://purl.obolibrary.org/obo/CL_0000737		
CL:0000738	biolink:Cell	leukocyte	An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.	FMA:62852|CALOHA:TS-0549|BTO:0000751	hp.json	white blood cell|immune cell|leucocyte	http://purl.obolibrary.org/obo/CL_0000738		
CHEBI:17859	biolink:ChemicalSubstance	glutaric acid	An alpha,omega-dicarboxylic acid that is a linear five-carbon dicarboxylic acid.	CAS:110-94-1|DrugBank:DB03553|Gmelin:26809|KEGG:C00489|PMID:24587932|CAS:110-94-1|CAS:110-94-1|PMID:24900967|PDBeChem:GUA|KNApSAcK:C00001184|PMID:24297153|LIPID_MAPS_instance:LMFA01170046|Wikipedia:Glutaric_acid|Beilstein:1209725|HMDB:HMDB0000661|Reaxys:1209725	hp.json	Pentanedioic acid|1,3-Propanedicarboxylic acid|1,5-pentanedioic acid|Glutaric acid|pentanedioic acid|Glutarsaeure|GLUTARIC ACID	http://purl.obolibrary.org/obo/CHEBI_17859		3_STAR
GO:0086001	biolink:BiologicalProcess	cardiac muscle cell action potential	An action potential that occurs in a cardiac muscle cell.		hp.json		http://purl.obolibrary.org/obo/GO_0086001		
CHEBI:17855	biolink:ChemicalSubstance	triglyceride	Any glyceride resulting from the condensation of all three hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.	KEGG:C00422|PMID:2474544|LIPID_MAPS_class:LMGL0301	hp.json	Triglyceride|a triacylglycerol|Triglyzerid|triacylglycerols|Triglycerid|triglycerides|triglycerides|Triacylglycerol	http://purl.obolibrary.org/obo/CHEBI_17855		3_STAR
GO:1904491	biolink:BiologicalProcess	protein localization to ciliary transition zone	A process in which a protein is transported to, or maintained in, a location within a ciliary transition zone.		hp.json	protein localization in ciliary transition zone|protein localisation to ciliary transition zone|protein localisation in ciliary transition zone	http://purl.obolibrary.org/obo/GO_1904491		
OIO:hasDbXref	biolink:NamedThing	database_cross_reference			hp.json		http://www.geneontology.org/formats/oboInOwl#hasDbXref		
UBERON:0010437	biolink:AnatomicalEntity	zygomaticus muscle	One of: zygomaticus major, zygomaticus minor.	EMAPA:37703|UMLS:C1710708|NCIT:C53182|MA:0002404	hp.json	m. zygomaticus|zygomaticus|m. levator nasii	http://purl.obolibrary.org/obo/UBERON_0010437		grouping_class
HGNC:10848	biolink:Gene	SHH (human)	A protein coding gene SHH in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=10848		
CHEBI:17883	biolink:ChemicalSubstance	hydrogen chloride	A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.	KEGG:D02057|PMID:15823700|Gmelin:322|CAS:7647-01-0|CAS:7647-01-0|PMID:17492841|Wikipedia:Hydrochloric_acid|KEGG:C01327|Drug_Central:4568|PMID:22804993|MetaCyc:HCL|Wikipedia:HCl|HMDB:HMDB0002306|Reaxys:1098214|CAS:7647-01-0	hp.json	[HCl]|HCl|Hydrochloride|Hydrogenchlorid|hydrogen chloride|chlorane|chlorure d'hydrogene|Wasserstoffchlorid|hydrochloric acid|Chlorwasserstoff|Hydrogen chloride|chloridohydrogen|cloruro de hidrogeno	http://purl.obolibrary.org/obo/CHEBI_17883		3_STAR
CL:0000710	biolink:Cell	neurecto-epithelial cell	Epithelial cells derived from neural plate and neural crest.	BTO:0004301|FMA:70557	hp.json	neuroepithelial cell	http://purl.obolibrary.org/obo/CL_0000710		
CL:0000712	biolink:Cell	stratum granulosum cell			hp.json		http://purl.obolibrary.org/obo/CL_0000712		
GO:0086029	biolink:BiologicalProcess	Purkinje myocyte to ventricular cardiac muscle cell signaling	Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.		hp.json	Purkinje myocyte to ventricular cardiac muscle cell signalling	http://purl.obolibrary.org/obo/GO_0086029		
CHEBI:30839	biolink:ChemicalSubstance	orotate		CAS:73-97-2|Gmelin:464718|Beilstein:3651747	hp.json	orotate|2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate	http://purl.obolibrary.org/obo/CHEBI_30839		3_STAR
GO:0086027	biolink:BiologicalProcess	AV node cell to bundle of His cell signaling	Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.		hp.json	atrioventricular node to bundle of His cell signaling|AV node cell to bundle of His cell signalling	http://purl.obolibrary.org/obo/GO_0086027		
UBERON:0010425	biolink:AnatomicalEntity	internal naris	A naris that is located inside the nasal cavity and connects to the pharynx.	NCIT:C32856	hp.json	choanae|internal choana|internal nares|internal nostril|choana	http://purl.obolibrary.org/obo/UBERON_0010425		pheno_slim
UBERON:0010423	biolink:AnatomicalEntity	primary lymphoid nodule of tonsil	A primary nodular lymphoid tissue that is part of a tonsil.	FMA:86018	hp.json	lymphoid nodule of tonsil	http://purl.obolibrary.org/obo/UBERON_0010423		
UBERON:0010424	biolink:AnatomicalEntity	distal segment of rib		MA:0001397|MA:0001418|EMAPA:37492	hp.json	distal rib segment|vertical segment of rib|distal part of rib|sternal rib|distal rib	http://purl.obolibrary.org/obo/UBERON_0010424		
UBERON:0010427	biolink:AnatomicalEntity	ciliary processes	The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens.	SCTID:280860001|FMA:76551|Wikipedia:Ciliary_processes	hp.json	processus ciliares|processus ciliares|ciliary process|set of ciliary processes|ciliary processes set|processus ciliares|ciliary processes|ciliary process	http://purl.obolibrary.org/obo/UBERON_0010427		
UBERON:0010428	biolink:AnatomicalEntity	flat bone	A bone that is shaped as a broad flat plate and composed of two thin layers of compact tissue enclosing between them a variable quantity of cancellous tissue, which is the location of red bone marrow.	SCTID:332907008|FMA:7476|galen:FlatBone|UMLS:C0222649|Wikipedia:Flat_bone|NCIT:C32616	hp.json	os planum|os planum	http://purl.obolibrary.org/obo/UBERON_0010428		
GO:0003674	biolink:MolecularActivity	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process.		hp.json	molecular function	http://purl.obolibrary.org/obo/GO_0003674		goslim_pir|goslim_plant|goslim_aspergillus|goslim_metagenomics|goslim_chembl|goslim_candida|goslim_yeast
GO:0003676	biolink:MolecularActivity	nucleic acid binding	Binding to a nucleic acid.		hp.json	base pairing	http://purl.obolibrary.org/obo/GO_0003676		goslim_pir|goslim_plant|goslim_chembl|goslim_metagenomics
GO:0003682	biolink:MolecularActivity	chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.		hp.json	microtubule/chromatin interaction|lamin/chromatin binding|nuclear membrane vesicle binding to chromatin	http://purl.obolibrary.org/obo/GO_0003682		goslim_pir|goslim_plant|goslim_drosophila|goslim_chembl|goslim_yeast
OIO:consider	biolink:NamedThing	consider			hp.json		http://www.geneontology.org/formats/oboInOwl#consider		
GO:0015669	biolink:BiologicalProcess	gas transport	The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0015669		goslim_pir
GO:0015630	biolink:CellularComponent	microtubule cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.		hp.json		http://purl.obolibrary.org/obo/GO_0015630		goslim_aspergillus
GO:0015631	biolink:MolecularActivity	tubulin binding	Binding to monomeric or multimeric forms of tubulin, including microtubules.		hp.json		http://purl.obolibrary.org/obo/GO_0015631		
HP:0012396	biolink:PhenotypicFeature	Biliary dyskinesia	A motility disorder characterized by biliary colic in the absence of gallstones with a reduced gallbladder ejection fraction.	MSH:D001657|SNOMEDCT_US:197432008|UMLS:C0005416	hp.json		http://purl.obolibrary.org/obo/HP_0012396		
HP:0012397	biolink:PhenotypicFeature	Aortic atherosclerotic lesion	The presence of atheromas or atherosclerotic plaques in the aorta.	SNOMEDCT_US:81817003|UMLS:C0155733	hp.json	Aortic atherosclerosis|Atherosclerosis of the aorta|Plaque build-up in aorta artery|Atherosclerotic changes of aorta	http://purl.obolibrary.org/obo/HP_0012397		
HP:0012398	biolink:PhenotypicFeature	Peripheral edema	An abnormal accumulation of interstitial fluid in the soft tissues of the limbs.	SNOMEDCT_US:82014009|UMLS:C0085649|SNOMEDCT_US:271809000	hp.json	Peripheral oedema	http://purl.obolibrary.org/obo/HP_0012398		
HP:0012399	biolink:PhenotypicFeature	Pressure ulcer	A type of ulcer that is caused when an area of skin is subject to pressure over a prolonged period of time, ranging in range in severity from patches of discolored skin to open wounds that expose the underlying bone or muscle. The most common sites are the sacrum, coccyx, heels and the hips.	SNOMEDCT_US:399912005|MSH:D003668|UMLS:C0011127|SNOMEDCT_US:420226006	hp.json	Bedsore|Pressure ulcer|Decubitus Ulcer|Pressure Sore	http://purl.obolibrary.org/obo/HP_0012399		
NCBITaxon:3398	biolink:OrganismalEntity	Magnoliopsida		GC_ID:1|PMID:25249442	hp.json	angiosperms|Angiospermae|Magnoliophyta|flowering plants|flowering plants	http://purl.obolibrary.org/obo/NCBITaxon_3398		
HP:0012390	biolink:PhenotypicFeature	Anal fissure	A small tear in the thin, moist tissue (mucosa) that lines the anus. It appears as a crack or slit in the mucous membrane of the anus.	MSH:D005401|SNOMEDCT_US:20928004|UMLS:C0016167|SNOMEDCT_US:30037006	hp.json	Anal erosion	http://purl.obolibrary.org/obo/HP_0012390		
HP:0012391	biolink:PhenotypicFeature	Hyporeflexia of upper limbs	Reduced intensity of muscle tendon reflexes in the upper limbs. Reflexes are elicited by stretching the tendon of a muscle, e.g., by tapping.	UMLS:C1836835	hp.json		http://purl.obolibrary.org/obo/HP_0012391		
HP:0012392	biolink:PhenotypicFeature	Jaw hyporeflexia	Reduced intensity of muscle tendon reflexes in jaw.	UMLS:C4022918	hp.json	Mandibular hyporeflexia	http://purl.obolibrary.org/obo/HP_0012392		
HP:0012393	biolink:PhenotypicFeature	Allergy	An allergy is an immune response or reaction to substances that are usually not harmful.	MSH:D006967|SNOMEDCT_US:419076005|UMLS:C1527304	hp.json	Allergy	http://purl.obolibrary.org/obo/HP_0012393		
HP:0012394	biolink:PhenotypicFeature	Iodine contrast allergy	Allergy to iodine contrast media used in radiological studies.	UMLS:C4022917	hp.json		http://purl.obolibrary.org/obo/HP_0012394		
HP:0012395	biolink:PhenotypicFeature	Seasonal allergy	An allergy experienced at a particular time of year when trees or grasses pollinate and elicit an allergic reaction.	UMLS:C0018621|SNOMEDCT_US:300910009|SNOMEDCT_US:367498001|SNOMEDCT_US:444316004|MSH:D006255|SNOMEDCT_US:21719001	hp.json	Seasonal allergy	http://purl.obolibrary.org/obo/HP_0012395		
CHEBI:39150	biolink:ChemicalSubstance	4-oxopentanoate	A member of the class of oxopentanoates that is the conjugate base of 4-oxopentanoic acid.	Gmelin:325844|Reaxys:3537533|Beilstein:3537533	hp.json	4-oxopentanoate|levulinate|4-ketovalerate|4-oxovalerate|laevulinate|gamma-ketovalerate|beta-acetylpropionate|levulate|3-acetylpropionate	http://purl.obolibrary.org/obo/CHEBI_39150		3_STAR
GO:1904409	biolink:BiologicalProcess	regulation of secretory granule organization	Any process that modulates the frequency, rate or extent of secretory granule organization.		hp.json	regulation of secretory granule organisation|regulation of secretory granule organization and biogenesis	http://purl.obolibrary.org/obo/GO_1904409		
CHEBI:27162	biolink:ChemicalSubstance	tryptamines	Tryptamine and its substitution derivatives.		hp.json		http://purl.obolibrary.org/obo/CHEBI_27162		3_STAR
GO:0015629	biolink:CellularComponent	actin cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.		hp.json		http://purl.obolibrary.org/obo/GO_0015629		goslim_aspergillus
UBERON:0009503	biolink:AnatomicalEntity	mesenchyme of hindgut	Mesenchyme that is part of a developing hindgut.	EMAPA:16716|EHDAA2:0000780	hp.json	hindgut associated mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009503		emapa_ehdaa2
CHEBI:27171	biolink:ChemicalSubstance	organic heterobicyclic compound			hp.json	organic heterobicyclic compounds|heterobicyclic compounds	http://purl.obolibrary.org/obo/CHEBI_27171		3_STAR
UBERON:0009505	biolink:AnatomicalEntity	mesenchyme of trachea	Mesenchyme that is part of a developing trachea.	EHDAA2:0002067|EMAPA:16854	hp.json	trachea associated mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009505		emapa_ehdaa2
UBERON:0009506	biolink:AnatomicalEntity	mesenchyme of middle ear	Mesenchyme that is part of a developing middle ear.	EMAPA:17001|EHDAA2:0001182	hp.json	otic mesenchyme|middle ear associated mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009506		emapa_ehdaa2
CHEBI:39144	biolink:ChemicalSubstance	Lewis base	A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct.		hp.json	Lewis base|donneur d'une paire d'electrons|base de Lewis|electron donor|Lewis-Base	http://purl.obolibrary.org/obo/CHEBI_39144		3_STAR
CHEBI:39142	biolink:ChemicalSubstance	Bronsted base	A molecular entity capable of accepting a hydron from a donor (Bronsted acid).		hp.json	accepteur d'hydron|Bronsted base|base de Bronsted|Bronsted-Base|hydron acceptor	http://purl.obolibrary.org/obo/CHEBI_39142		3_STAR
CHEBI:39141	biolink:ChemicalSubstance	Bronsted acid	A molecular entity capable of donating a hydron to an acceptor (Bronsted base).		hp.json	donneur d'hydron|acide de Bronsted|hydron donor|Bronsted acid|Bronsted-Saeure	http://purl.obolibrary.org/obo/CHEBI_39141		3_STAR
UBERON:0009500	biolink:AnatomicalEntity	periotic mesenchyme	Anatomical region that surrounds the otic vesicle.	EMAPA:16670|XAO:0004474|EHDAA2:0001343	hp.json	otocyst associated mesenchyme|periotic region|otocyst mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009500		emapa_ehdaa2
UBERON:0009501	biolink:AnatomicalEntity	mesenchyme of fronto-nasal process	The embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head.	EMAPA:16683|FMA:295821|EHDAA2:0004109	hp.json	frontonasal mesenchyme|naso-frontal mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009501		emapa_ehdaa2|pheno_slim
CL:0000787	biolink:Cell	memory B cell	A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative.		hp.json	memory B lymphocyte|memory B-lymphocyte|memory B-cell	http://purl.obolibrary.org/obo/CL_0000787		
CL:0000788	biolink:Cell	naive B cell	A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery.		hp.json	naive B-cell|naive B lymphocyte|naive B-lymphocyte	http://purl.obolibrary.org/obo/CL_0000788		
CL:0000789	biolink:Cell	alpha-beta T cell	A T cell that expresses an alpha-beta T cell receptor complex.		hp.json	alpha-beta T lymphocyte|alpha-beta T-lymphocyte|alpha-beta T-cell	http://purl.obolibrary.org/obo/CL_0000789		
GO:1904414	biolink:BiologicalProcess	positive regulation of cardiac ventricle development	Any process that activates or increases the frequency, rate or extent of cardiac ventricle development.		hp.json	up-regulation of cardiac ventricle development|up regulation of cardiac ventricle development|activation of cardiac ventricle development|upregulation of cardiac ventricle development	http://purl.obolibrary.org/obo/GO_1904414		
CHEBI:27136	biolink:ChemicalSubstance	triol	A chemical compound containing three hydroxy groups.		hp.json	triols	http://purl.obolibrary.org/obo/CHEBI_27136		3_STAR
GO:1904413	biolink:BiologicalProcess	negative regulation of cardiac ventricle development	Any process that stops, prevents or reduces the frequency, rate or extent of cardiac ventricle development.		hp.json	inhibition of cardiac ventricle development|downregulation of cardiac ventricle development|down-regulation of cardiac ventricle development|down regulation of cardiac ventricle development	http://purl.obolibrary.org/obo/GO_1904413		
GO:1904412	biolink:BiologicalProcess	regulation of cardiac ventricle development	Any process that modulates the frequency, rate or extent of cardiac ventricle development.		hp.json		http://purl.obolibrary.org/obo/GO_1904412		
GO:1904411	biolink:BiologicalProcess	positive regulation of secretory granule organization	Any process that activates or increases the frequency, rate or extent of secretory granule organization.		hp.json	up regulation of secretory granule organization|upregulation of secretory granule organization and biogenesis|activation of secretory granule organization and biogenesis|up-regulation of secretory granule organization|upregulation of secretory granule organisation|activation of secretory granule organization|positive regulation of secretory granule organisation|up-regulation of secretory granule organization and biogenesis|up regulation of secretory granule organisation|upregulation of secretory granule organization|up regulation of secretory granule organization and biogenesis|positive regulation of secretory granule organization and biogenesis|up-regulation of secretory granule organisation|activation of secretory granule organisation	http://purl.obolibrary.org/obo/GO_1904411		
CHEBI:29793	biolink:ChemicalSubstance	hydridodioxygen(1+)		Gmelin:508	hp.json	HOO(+)|HO2(+)|[HO2](+)|hydridodioxygen(1+)|dioxidenium	http://purl.obolibrary.org/obo/CHEBI_29793		3_STAR
GO:1904410	biolink:BiologicalProcess	negative regulation of secretory granule organization	Any process that stops, prevents or reduces the frequency, rate or extent of secretory granule organization.		hp.json	down-regulation of secretory granule organization and biogenesis|negative regulation of secretory granule organization and biogenesis|down regulation of secretory granule organisation|inhibition of secretory granule organisation|down regulation of secretory granule organization and biogenesis|down-regulation of secretory granule organisation|downregulation of secretory granule organization|negative regulation of secretory granule organisation|downregulation of secretory granule organization and biogenesis|down regulation of secretory granule organization|inhibition of secretory granule organization|down-regulation of secretory granule organization|inhibition of secretory granule organization and biogenesis|downregulation of secretory granule organisation	http://purl.obolibrary.org/obo/GO_1904410		
CL:0000782	biolink:Cell	myeloid dendritic cell	A dendritic cell of the myeloid lineage.	BTO:0004721	hp.json	veiled cell|mDC|CD11c+CD123- DC|interdigitating cell	http://purl.obolibrary.org/obo/CL_0000782		
CL:0000785	biolink:Cell	mature B cell	A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen.		hp.json	mature B-cell|mature B lymphocyte|mature B-lymphocyte	http://purl.obolibrary.org/obo/CL_0000785		
PR:Q12882	biolink:Protein	dihydropyrimidine dehydrogenase [NADP(+)] (human)	A dihydropyrimidine dehydrogenase [NADP(+)] that is encoded in the genome of human.	UniProtKB:Q12882	hp.json	DPYD|DPD (human)|hDPYD|DHPDHase (human)|dihydrouracil dehydrogenase (human)|dihydrothymine dehydrogenase (human)	http://purl.obolibrary.org/obo/PR_Q12882		
GO:0050000	biolink:BiologicalProcess	chromosome localization	Any process in which a chromosome is transported to, or maintained in, a specific location.		hp.json	establishment and maintenance of chromosome position|establishment and maintenance of chromosome localization|chromosome localisation	http://purl.obolibrary.org/obo/GO_0050000		
CL:0000798	biolink:Cell	gamma-delta T cell	A T cell that expresses a gamma-delta T cell receptor complex.		hp.json	gamma-delta T-cell|gamma-delta T lymphocyte|gamma-delta T-lymphocyte|gammadelta T cell|gd T cell	http://purl.obolibrary.org/obo/CL_0000798		
CL:0000799	biolink:Cell	immature gamma-delta T cell	A gamma-delta T cell that has an immature phenotype.		hp.json	immature gamma-delta T-lymphocyte|immature gamma-delta T-cell|immature gamma-delta T lymphocyte	http://purl.obolibrary.org/obo/CL_0000799		
CHEBI:88167	biolink:ChemicalSubstance	N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide	A glycotetraosylceramide having N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl  component attached to the primary hydroxy function of a ceramide with undefined sphingoid base.		hp.json	globoside Gb4Cer|beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer|beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer	http://purl.obolibrary.org/obo/CHEBI_88167		3_STAR
CL:0000790	biolink:Cell	immature alpha-beta T cell	An alpha-beta T cell that has an immature phenotype and has not completed T cell selection.		hp.json	immature alpha-beta T-lymphocyte|immature alpha-beta T-cell|immature alpha-beta T lymphocyte	http://purl.obolibrary.org/obo/CL_0000790		
CL:0000791	biolink:Cell	mature alpha-beta T cell	A alpha-beta T cell that has a mature phenotype.		hp.json	mature alpha-beta T-cell|mature alpha-beta T lymphocyte|mature alpha-beta T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000791		
CL:0000792	biolink:Cell	CD4-positive, CD25-positive, alpha-beta regulatory T cell	A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.		hp.json	suppressor T-lymphocyte|CD4-positive, CD25-positive, alpha-beta regulatory T-cell|CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte|Treg|CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte|suppressor T cell|suppressor T-cell|suppressor T lymphocyte	http://purl.obolibrary.org/obo/CL_0000792		
CHEBI:27150	biolink:ChemicalSubstance	trisaccharide		Wikipedia:Trisaccharide	hp.json	trisaccharides	http://purl.obolibrary.org/obo/CHEBI_27150		3_STAR
CHEBI:30795	biolink:ChemicalSubstance	malonate(1-)		Gmelin:324637|Beilstein:3904186	hp.json	HOOC-CH2-COO(-)|Malonic acid, conjugate base|carboxyacetate|Hmalo	http://purl.obolibrary.org/obo/CHEBI_30795		3_STAR
CHEBI:30794	biolink:ChemicalSubstance	malonic acid	An alpha,omega-dicarboxylic acid in which the two carboxy groups are separated by a single methylene group.	MetaCyc:MALONATE|PDBeChem:MLA|KNApSAcK:C00001193|KEGG:C00383|CAS:141-82-2|LIPID_MAPS_instance:LMFA01170041|Gmelin:2550|HMDB:HMDB0000691|CAS:141-82-2|CAS:141-82-2|DrugBank:DB02175|Reaxys:1751370|Beilstein:1751370|PMID:22770225|Wikipedia:Malonic_acid	hp.json	HOOC-CH2-COOH|Malonic acid|Propanedioic acid|MALONIC ACID|H2malo|propanedioic acid	http://purl.obolibrary.org/obo/CHEBI_30794		3_STAR
HP:0012341	biolink:PhenotypicFeature	Microprolactinoma	A pituitary prolactin cell adenoma of less than 10 mm diameter.	SNOMEDCT_US:253010003|MSH:D015175|UMLS:C0344452	hp.json		http://purl.obolibrary.org/obo/HP_0012341		
HP:0012342	biolink:PhenotypicFeature	Macroprolactinoma	A pituitary prolactin cell adenoma of more than 10 mm diameter.	SNOMEDCT_US:253011004|MSH:D015175|UMLS:C0344453	hp.json		http://purl.obolibrary.org/obo/HP_0012342		
HP:0012343	biolink:PhenotypicFeature	Decreased circulating ferritin concentration	Abnormally reduced concentration of ferritin, a ubiquitous intracellular protein that stores iron, in the blood.	UMLS:C0241012	hp.json	Reduced serum ferritin|Decreased serum ferritin|Low ferritin level|Decreased plasma ferritin	http://purl.obolibrary.org/obo/HP_0012343		
HP:0012344	biolink:PhenotypicFeature	Morphea	Isolated patches of hardened skin (scleroderma).	UMLS:C1527383|SNOMEDCT_US:201049004|MSH:D012594	hp.json		http://purl.obolibrary.org/obo/HP_0012344		
HP:0012345	biolink:PhenotypicFeature	Abnormal glycosylation	An anomaly of a glycosylation process, i.e., a process involved in the covalent attachment of a glycosyl residue to a substrate molecule.	UMLS:C4022946	hp.json		http://purl.obolibrary.org/obo/HP_0012345		
HP:0012346	biolink:PhenotypicFeature	Abnormal protein glycosylation	An anomaly of a protein glycosylation process, i.e., of a protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.	UMLS:C4022945	hp.json		http://purl.obolibrary.org/obo/HP_0012346		
HP:0012347	biolink:PhenotypicFeature	Abnormal protein N-linked glycosylation	An anomaly of protein N-linked glycosylation, i.e., an abnormality of the protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a nitrogen atom in an amino acid residue in a protein.	UMLS:C4022944	hp.json		http://purl.obolibrary.org/obo/HP_0012347		
HP:0012348	biolink:PhenotypicFeature	Decreased galactosylation of N-linked protein glycosylation	A reduction in the amount of galactose residues of N-glycans.	UMLS:C4022943	hp.json		http://purl.obolibrary.org/obo/HP_0012348		
NCBITaxon:119089	biolink:OrganismalEntity	Chromadorea		GC_ID:1	hp.json	Adenophorea	http://purl.obolibrary.org/obo/NCBITaxon_119089		
HP:0000359	biolink:PhenotypicFeature	Abnormality of the inner ear	An abnormality of the inner ear.	UMLS:C4021809	hp.json	Inner ear abnormality|Abnormality of the inner ear	http://purl.obolibrary.org/obo/HP_0000359		
HP:0012340	biolink:PhenotypicFeature	Decreased resting energy expenditure	A reduction in the number of calories used per unit time.	UMLS:C4022947	hp.json		http://purl.obolibrary.org/obo/HP_0012340		
HP:0000356	biolink:PhenotypicFeature	Abnormality of the outer ear	An abnormality of the external ear.	UMLS:C1846460|UMLS:C0266589|SNOMEDCT_US:275259005	hp.json	Malformed pinnae|External ear malformations|Ear anomalies|Outer ear abnormality|Abnormality of the outer ear|Abnormal pinnae|Abnormality of the external ear|Abnormality of the auricle	http://purl.obolibrary.org/obo/HP_0000356		
HP:0000358	biolink:PhenotypicFeature	Posteriorly rotated ears	A type of abnormal location of the ears in which the position of the ears is characterized by posterior rotation (the superior part of the ears is rotated towards the back of the head, and the inferior part of the ears towards the front).	SNOMEDCT_US:253251006|UMLS:C0431478	hp.json	Ear, posterior angulation, increased|Posteriorly angulated ears|Posteriorly rotated auricles|Posteriorly-angulated ears|Ears rotated toward back of head|Posteriorly-rotated ears|Posteriorly rotated	http://purl.obolibrary.org/obo/HP_0000358		hposlim_core
HP:0000357	biolink:PhenotypicFeature	Abnormal location of ears	Abnormal location of the ear.	UMLS:C4021810	hp.json	Abnormal location of ears|External ear position defect	http://purl.obolibrary.org/obo/HP_0000357		
HP:0012349	biolink:PhenotypicFeature	Abnormal sialylation of N-linked protein glycosylation	An anomaly of the addition of sialic acids to N-linked glycans.	UMLS:C4022942	hp.json		http://purl.obolibrary.org/obo/HP_0012349		
HP:0000350	biolink:PhenotypicFeature	Small forehead	The presence of a forehead that is abnormally small.	UMLS:C1845250|UMLS:C4280634|UMLS:C4280633	hp.json	Small forehead|Hypoplasia of forehead|Hypotrophic forehead|Decreased size of forehead|Decreased size of frontal region of face	http://purl.obolibrary.org/obo/HP_0000350		
HP:0012330	biolink:PhenotypicFeature	Pyelonephritis	An inflammation of the kidney involving the parenchyma of kidney, the renal pelvis and the kidney calices.	SNOMEDCT_US:45816000|MSH:D011704|UMLS:C0034186	hp.json		http://purl.obolibrary.org/obo/HP_0012330		
HP:0012331	biolink:PhenotypicFeature	Abnormal autonomic nervous system morphology	A structural abnormality of the autonomic nervous system.	UMLS:C4022953	hp.json		http://purl.obolibrary.org/obo/HP_0012331		
HP:0012332	biolink:PhenotypicFeature	Abnormal autonomic nervous system physiology	A functional abnormality of the autonomic nervous system.	UMLS:C4022952	hp.json	Autonomic dysregulation|Autonomic dysfunction|Dysautonomia	http://purl.obolibrary.org/obo/HP_0012332		
HP:0012333	biolink:PhenotypicFeature	Abnormal sudomotor regulation	An abnormal regulation of the sweat glands by the sympathetic nervous system associated with abnormal perspiration.	UMLS:C4021092	hp.json	Sudomotor sympathetic dysfunction	http://purl.obolibrary.org/obo/HP_0012333		
HP:0012334	biolink:PhenotypicFeature	Extrahepatic cholestasis	Impairment of bile flow due to obstruction in large bile ducts outside the liver.	MSH:D001651|SNOMEDCT_US:20719006|SNOMEDCT_US:8262006|UMLS:C0005398	hp.json		http://purl.obolibrary.org/obo/HP_0012334		
HP:0012335	biolink:PhenotypicFeature	Abnormality of folate metabolism	An abnormality of the metabolism of folic acid, which is also known as vitamin B9.	UMLS:C4022951	hp.json		http://purl.obolibrary.org/obo/HP_0012335		
HP:0012336	biolink:PhenotypicFeature	obsolete Reduced cerebrospinal fluid 5-methyltetrahydrofolate concentration			hp.json		http://purl.obolibrary.org/obo/HP_0012336		
HP:0012337	biolink:PhenotypicFeature	Abnormal homeostasis	An anomaly in the processes involved in the maintenance of an internal equilibrium.	UMLS:C4022950|MP:0001764	hp.json		http://purl.obolibrary.org/obo/HP_0012337		
HP:0000363	biolink:PhenotypicFeature	Abnormal earlobe morphology	An abnormality of the lobule of pinna.	UMLS:C4021808	hp.json	Abnormal lobe of ear|Abnormality of auricular lobule|Abnormal earlobe|Abnormality of lobulus auriculae|Abnormality of ear lobe|Abnormality of earlobe	http://purl.obolibrary.org/obo/HP_0000363		hposlim_core
HP:0000362	biolink:PhenotypicFeature	Otosclerosis	In otosclerosis, a callus of bone accumulates on the stapes creating a partial fixation. This limits the movement of the stapes bone, which results in hearing loss.	MSH:D010040|UMLS:C0029899|SNOMEDCT_US:11543004	hp.json		http://purl.obolibrary.org/obo/HP_0000362		hposlim_core
HP:0000365	biolink:PhenotypicFeature	Hearing impairment	A decreased magnitude of the sensory perception of sound.	SNOMEDCT_US:103276001|SNOMEDCT_US:343087000|SNOMEDCT_US:95828007|SNOMEDCT_US:15188001|Fyler:4868|MSH:D034381|UMLS:C0339789|UMLS:C0011053|MSH:D003638|UMLS:C0018772|UMLS:C1384666	hp.json	Hearing impairment|Hypacusis|Hypoacusis|Hearing defect|Deafness|Hearing loss	http://purl.obolibrary.org/obo/HP_0000365		
HP:0000364	biolink:PhenotypicFeature	Hearing abnormality	An abnormality of the sensory perception of sound.	UMLS:C4025860	hp.json	Abnormal hearing|Hearing abnormality	http://purl.obolibrary.org/obo/HP_0000364		
HP:0000366	biolink:PhenotypicFeature	Abnormality of the nose	An abnormality of the nose.	UMLS:C2235909|SNOMEDCT_US:128274005|UMLS:C0240547|UMLS:C0265736|SNOMEDCT_US:72089000	hp.json	Nasal malformation|Nasal abnormality|Nasal anomaly|Anomaly of the nose|Abnormality of the nose|Deformity of the nose|Malformation of the nose|Nasal deformity	http://purl.obolibrary.org/obo/HP_0000366		hposlim_core
HP:0000369	biolink:PhenotypicFeature	Low-set ears	Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear.	UMLS:C0239234|SNOMEDCT_US:95515009	hp.json	Melotia|Low set ears|Low-set ears|Lowset ears|Low-set pinnae	http://purl.obolibrary.org/obo/HP_0000369		hposlim_core
HP:0000368	biolink:PhenotypicFeature	Low-set, posteriorly rotated ears	Ears that are low-set (HP:0000369) and posteriorly rotated (HP:0000358).	UMLS:C1857486	hp.json	Low-set posteriorly rotated ears	http://purl.obolibrary.org/obo/HP_0000368		
HP:0012338	biolink:PhenotypicFeature	Abnormal energy expenditure	Any anomaly in the utilization of energy (calories).	UMLS:C4022949	hp.json	Abnormal energy expenditure	http://purl.obolibrary.org/obo/HP_0012338		
HP:0012339	biolink:PhenotypicFeature	Increased resting energy expenditure	An increase in the number of calories used per unit time.	UMLS:C4022948	hp.json		http://purl.obolibrary.org/obo/HP_0012339		
HP:0000361	biolink:PhenotypicFeature	obsolete Pulsatile tinnitus (tympanic paraganglioma)			hp.json		http://purl.obolibrary.org/obo/HP_0000361		
HP:0000360	biolink:PhenotypicFeature	Tinnitus	Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation.	UMLS:C0040264|MSH:D014012|SNOMEDCT_US:162349004|SNOMEDCT_US:162352007|SNOMEDCT_US:60862001	hp.json	Ringing in the ears|Ringing in ears	http://purl.obolibrary.org/obo/HP_0000360		hposlim_core
HP:0012320	biolink:PhenotypicFeature	Absent pigmentation of the limbs	Lack of skin pigmentation (coloring) of the arms and legs.	UMLS:C4022955	hp.json		http://purl.obolibrary.org/obo/HP_0012320		
HP:0012321	biolink:PhenotypicFeature	D-2-hydroxyglutaric aciduria	An increased concentration of 2-hydroxyglutaric acid in the urine.	SNOMEDCT_US:237960000|UMLS:C1833429	hp.json		http://purl.obolibrary.org/obo/HP_0012321		
HP:0012322	biolink:PhenotypicFeature	Perifolliculitis	Inflammation surrounding hair follicles.	UMLS:C0263006|SNOMEDCT_US:83341004	hp.json	Perifollicular inflammation	http://purl.obolibrary.org/obo/HP_0012322		
HP:0012323	biolink:PhenotypicFeature	Sleep myoclonus	Myoclonus that occurs during the initial phases of sleep.	SNOMEDCT_US:34101000119105|MSH:D009207|UMLS:C0751352	hp.json		http://purl.obolibrary.org/obo/HP_0012323		
HP:0012324	biolink:PhenotypicFeature	Myeloid leukemia	A leukemia that originates from a myeloid cell, that is the blood forming cells of the bone marrow.	SNOMEDCT_US:188732008|SNOMEDCT_US:128934006|SNOMEDCT_US:37810007|MSH:D007951|UMLS:C0023470	hp.json	Myeloid leukaemia	http://purl.obolibrary.org/obo/HP_0012324		
HP:0012325	biolink:PhenotypicFeature	Chronic myelomonocytic leukemia	A myelodysplastic/myeloproliferative neoplasm which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20 percent blasts in the bone marrow and blood, myelodysplasia, and absence of PDGFRA or PDGFRB rearrangement.	UMLS:C0023480|SNOMEDCT_US:127225006|SNOMEDCT_US:128831004|MSH:D015477	hp.json	Chronic myelomonocytic leukaemia	http://purl.obolibrary.org/obo/HP_0012325		
HP:0012326	biolink:PhenotypicFeature	Abnormal celiac artery morphology	An anomaly of the celiac artery.	UMLS:C4022954	hp.json	Abnormal coeliac artery morphology|Abnormality of the coeliac artery|Abnormality of the celiac artery	http://purl.obolibrary.org/obo/HP_0012326		
HP:0000338	biolink:PhenotypicFeature	Hypomimic face	A reduced degree of motion of the muscles beneath the skin of the face, often associated with reduced facial crease formation.	SNOMEDCT_US:248149005|UMLS:C4280635|UMLS:C1862474|UMLS:C0813217	hp.json	Decreased facial muscle movement|Dull facial expression|Decreased facial expressions|Hypomimia	http://purl.obolibrary.org/obo/HP_0000338		
HP:0000337	biolink:PhenotypicFeature	Broad forehead	Width of the forehead or distance between the frontotemporales is more than two standard deviations above the mean (objective); or apparently increased distance between the two sides of the forehead.	UMLS:C1849089	hp.json	Increased width of the forehead|Intertemporal widening|Broad forehead|Wide forehead|Increased bitemporal dimension|Increased bitemporal width|Bitemporal widening	http://purl.obolibrary.org/obo/HP_0000337		hposlim_core
HP:0002999	biolink:PhenotypicFeature	Patellar dislocation	The kneecap normally is located within the groove termed trochlea on the distal femur and can slide up and down in it. Patellar dislocation occurs if the patella fully dislocates out of the groove.	MSH:D031222|UMLS:C1135812|SNOMEDCT_US:263029007	hp.json	Dislocation of patella|Dislocated patellae|Dislocated kneecap	http://purl.obolibrary.org/obo/HP_0002999		
HP:0000339	biolink:PhenotypicFeature	Pugilistic facies	Coarse facial features reminiscent of those of a boxer.	UMLS:C1846011	hp.json	Pugilistic facial appearance|Boxer-like facial appearance	http://purl.obolibrary.org/obo/HP_0000339		
HP:0002991	biolink:PhenotypicFeature	Abnormality of fibula morphology	An anomaly of the calf bone (fibula), one of the two bones of the calf.	UMLS:C4025664	hp.json	Abnormality of the calf bone	http://purl.obolibrary.org/obo/HP_0002991		hposlim_core
HP:0000331	biolink:PhenotypicFeature	Short chin	Decreased vertical distance from the vermilion border of the lower lip to the inferior-most point of the chin.	UMLS:C1839323|UMLS:C3697248|SNOMEDCT_US:699439001	hp.json	Vertical hypoplasia of chin|Short lower third of face|Vertical deficiency of chin|Decreased height of chin|Small chin|Short chin	http://purl.obolibrary.org/obo/HP_0000331		
HP:0002992	biolink:PhenotypicFeature	Abnormality of tibia morphology	Abnormality of the tibia (shinbone).	UMLS:C4025663	hp.json	Abnormality of the shankbone|Abnormality of the shinbone	http://purl.obolibrary.org/obo/HP_0002992		
HP:0002997	biolink:PhenotypicFeature	obsolete Abnormality of the ulna			hp.json		http://purl.obolibrary.org/obo/HP_0002997		
HP:0000336	biolink:PhenotypicFeature	Prominent supraorbital ridges	Greater than average forward and/or lateral protrusion of the supraorbital portion of the frontal bones.	UMLS:C4280639|UMLS:C1842060|UMLS:C4280638|UMLS:C4280637|UMLS:C4280636	hp.json	Hyperplasia of supraorbital ridge|Prominent supraorbital margins|Hypertrophy of supraorbital margins|Prominent supraorbital ridge|Hypertrophy of supraorbital ridge|Protruding supraorbital ridge|Supraorbital hyperostosis|Prominent brow|Hyperplasia of supraorbital margins	http://purl.obolibrary.org/obo/HP_0000336		hposlim_core
HP:0002996	biolink:PhenotypicFeature	Limited elbow movement		UMLS:C1849955	hp.json	Limited elbow mobility|Restricted elbow motion|Decreased elbow mobility|Limited elbow movement	http://purl.obolibrary.org/obo/HP_0002996		
HP:0012327	biolink:PhenotypicFeature	Celiac artery compression	Compression of the celiac artery.	UMLS:C4020693|UMLS:C0152098|SNOMEDCT_US:9250002	hp.json	Dunbar syndrome|Coeliac axis syndrome|Median arcuate ligament syndrome|Celiac axis syndrome|Coeliac artery compression	http://purl.obolibrary.org/obo/HP_0012327		
HP:0012328	biolink:PhenotypicFeature	Cementoma	An odontogenic tumor of the cementum of tooth.	SNOMEDCT_US:37258009|MSH:D002485|UMLS:C0007659|SNOMEDCT_US:23255001	hp.json		http://purl.obolibrary.org/obo/HP_0012328		
HP:0012329	biolink:PhenotypicFeature	Tufted angioma	A vascular tumor of the skin and subcutaneous tissues and characterized by slow angiomatous proliferation.	UMLS:C0346073|MSH:C536924|SNOMEDCT_US:705155008|SNOMEDCT_US:254786000	hp.json	Tufted hemangioma|Angioblastoma of Nakagawa|Hypertrophic hemangioma|Angioblastoma|Progressive capillary hemangioma	http://purl.obolibrary.org/obo/HP_0012329		
HP:0002990	biolink:PhenotypicFeature	Fibular aplasia	Absence of the fibula.	UMLS:C1836186|MEDDRA:10054882	hp.json	Absent calf bone|Absent-hypoplastic fibulae|Absent fibulae	http://purl.obolibrary.org/obo/HP_0002990		hposlim_core
HP:0012310	biolink:PhenotypicFeature	Abnormal monocyte count	An anomaly in the number of monocytes, which are myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.	SNOMEDCT_US:165540007|SNOMEDCT_US:165541006|UMLS:C0580319	hp.json	Abnormal monocyte number	http://purl.obolibrary.org/obo/HP_0012310		
HP:0012311	biolink:PhenotypicFeature	Monocytosis	An increased number of circulating monocytes.	UMLS:C0085702|SNOMEDCT_US:19636003	hp.json	High blood monocyte number	http://purl.obolibrary.org/obo/HP_0012311		
HP:0012312	biolink:PhenotypicFeature	Monocytopenia	An decreased number of circulating monocytes.	SNOMEDCT_US:165539005|UMLS:C0427544	hp.json	Low blood monocyte number	http://purl.obolibrary.org/obo/HP_0012312		
HP:0012313	biolink:PhenotypicFeature	Heberden's node	Bony swelling of the distal interphalangeal joint (DIP) associated with the formation of osteophytes (calcific spurs) of the articular (joint) cartilage that are visible radiographically.	UMLS:C0018862|SNOMEDCT_US:371598009	hp.json		http://purl.obolibrary.org/obo/HP_0012313		
HP:0012314	biolink:PhenotypicFeature	Bouchard's node	Bony swelling of the proximal interphalangeal joint (PIP) associated with the formation of osteophytes (calcific spurs) of the articular (joint) cartilage that are visible radiographically.	SNOMEDCT_US:20243008|UMLS:C0263780	hp.json		http://purl.obolibrary.org/obo/HP_0012314		
HP:0012315	biolink:PhenotypicFeature	Histiocytoma	A neoplasm containing histiocytes.	MSH:D051642|SNOMEDCT_US:128741006|UMLS:C1509147|SNOMEDCT_US:302843004	hp.json		http://purl.obolibrary.org/obo/HP_0012315		
HP:0000349	biolink:PhenotypicFeature	Widow's peak	Frontal hairline with bilateral arcs to a low point in the midline of the forehead.	UMLS:C1853486	hp.json	Pointed hairline at front of head|Pointed frontal hairline|Hairline peak|V-shaped frontal hairline|Widow's peak|Hairline point	http://purl.obolibrary.org/obo/HP_0000349		hposlim_core
HP:0000348	biolink:PhenotypicFeature	High forehead	An abnormally increased height of the forehead.	UMLS:C2677762|UMLS:C0239676	hp.json	Tall forehead|High forehead	http://purl.obolibrary.org/obo/HP_0000348		
HP:0000341	biolink:PhenotypicFeature	Narrow forehead	Width of the forehead or distance between the frontotemporales is more than two standard deviations below the mean (objective); or apparently narrow intertemporal region (subjective).	UMLS:C1839758	hp.json	Bitemporal narrowing|Temporal narrowness|Narrow bitemporal diameter|Bitemporal skull narrowing|Bitemporal narrowness|Narrow forehead|Decreased width of the forehead|Intertemporal narrowing|Narrow bitemporal width	http://purl.obolibrary.org/obo/HP_0000341		hposlim_core
HP:0000340	biolink:PhenotypicFeature	Sloping forehead	Inclination of the anterior surface of the forehead from the vertical more than two standard deviations above the mean (objective); or apparently excessive posterior sloping of the forehead in a lateral view.	UMLS:C1857679	hp.json	Inclined forehead|Receding forehead|Sloping forehead|Posteriorly sloping forehead	http://purl.obolibrary.org/obo/HP_0000340		hposlim_core
HP:0000343	biolink:PhenotypicFeature	Long philtrum	Distance between nasal base and midline upper lip vermilion border more than 2 SD above the mean. Alternatively, an apparently increased distance between nasal base and midline upper lip vermilion border.	UMLS:C1865014	hp.json	Increased vertical dimension of philtrum|Vertical hyperplasia of philtrum|Increased height of philtrum|Increased length of philtrum|Elongated philtrum	http://purl.obolibrary.org/obo/HP_0000343		hposlim_core
HP:0000347	biolink:PhenotypicFeature	Micrognathia	Developmental hypoplasia of the mandible.	SNOMEDCT_US:32958008|Fyler:4163|UMLS:C1857130|MSH:D008844|UMLS:C0240295|UMLS:C0025990	hp.json	Retrusion of lower jaw|Mandibular retrusion|Lower jaw hypoplasia|Robin mandible|Hypotrophic mandible|Decreased size of mandible|Micromandible|Decreased projection of lower jaw|Small lower jaw|Mandibular deficiency|Small jaw|Little lower jaw|Mandibular retrognathia|Decreased size of lower jaw|Decreased projection of mandible|Deficiency of lower jaw|Hypotrophic lower jaw|Hypoplastic mandible|Hypoplastic mandible condyle|Hypoplasia of mandible|Mandibular hypoplasia|Hypoplasia of lower jaw|Lower jaw retrusion|Lower jaw deficiency|Underdevelopment of mandible|Severe hypoplasia of mandible|Mandibular micrognathia|Little mandible|Micrognathia of lower jaw|Underdevelopment of lower jaw|Small mandible	http://purl.obolibrary.org/obo/HP_0000347		hposlim_core
HP:0000346	biolink:PhenotypicFeature	Whistling appearance	An abnormality of facial morphology characterized by a small mouth opening and constant contraction of the lips as if the patient were whistling.	UMLS:C1848473	hp.json	Whistling facial appearance|Whistling appearance	http://purl.obolibrary.org/obo/HP_0000346		
HP:0012316	biolink:PhenotypicFeature	Fibrous tissue neoplasm	Any neoplasm composed of fibrous tissue.	UMLS:C0206643|MSH:D018218	hp.json		http://purl.obolibrary.org/obo/HP_0012316		
HP:0012317	biolink:PhenotypicFeature	Sacroiliac arthritis	Inflammation of the sacroiliac joint, generally accompanied by lower back pain.	MSH:C563037|UMLS:C0748473	hp.json	Sacroiliitis	http://purl.obolibrary.org/obo/HP_0012317		
HP:0012318	biolink:PhenotypicFeature	Occipital neuralgia	A distinct type of headache characterized by piercing, throbbing, or electric-shock-like chronic pain in the upper neck, back of the head, and behind the ears, usually on one side.	UMLS:C0007863|SNOMEDCT_US:71760005	hp.json		http://purl.obolibrary.org/obo/HP_0012318		
HP:0012319	biolink:PhenotypicFeature	Absent pigmentation of the abdomen	Lack of skin pigmentation (coloring) of the abdomen.	UMLS:C4022956	hp.json		http://purl.obolibrary.org/obo/HP_0012319		
HP:0012385	biolink:PhenotypicFeature	Camptodactyly	The distal interphalangeal joint and/or the proximal interphalangeal joint of the fingers or toes cannot be extended to 180 degrees by either active or passive extension.	UMLS:C0685409|SNOMEDCT_US:29271008	hp.json	Permanent flexion of the finger or toe	http://purl.obolibrary.org/obo/HP_0012385		hposlim_core
HP:0012386	biolink:PhenotypicFeature	Absent hallux	Aplasia of the hallux, that is, a development defect such that the big toe does not develop.	UMLS:C1841686	hp.json	Missing big toe|Agenesis of the halluces|Absent big toe|Aplasia of the hallux	http://purl.obolibrary.org/obo/HP_0012386		
HP:0012387	biolink:PhenotypicFeature	Bronchitis	Inflammation of the large airways in the lung including any part of the bronchi from the primary bronchi to the tertiary bronchi.	SNOMEDCT_US:32398004|UMLS:C0006277|MSH:D001991	hp.json		http://purl.obolibrary.org/obo/HP_0012387		
HP:0012388	biolink:PhenotypicFeature	Acute bronchitis	Inflammation of the large airways of the lung with rapid onset and short course usually associated with cough, mucus production, shortness of breath, wheezing, and chest tightness.	UMLS:C0149514|SNOMEDCT_US:35301006|SNOMEDCT_US:10509002	hp.json		http://purl.obolibrary.org/obo/HP_0012388		
HP:0012389	biolink:PhenotypicFeature	Appendicular hypotonia	Muscular hypotonia of one or more limbs.	UMLS:C4022919	hp.json		http://purl.obolibrary.org/obo/HP_0012389		
HP:0012380	biolink:PhenotypicFeature	Reduced carnitine O-palmitoyltransferase level	Reduced carnitine O-palmitoyltransferase level, leading to a reduced activity of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.	UMLS:C4022921	hp.json		http://purl.obolibrary.org/obo/HP_0012380		
HP:0012381	biolink:PhenotypicFeature	Delayed self-feeding during toddler years	A delay in the development of skills required to feed oneself in the toddler period (between one and three years of age).	UMLS:C4022920	hp.json		http://purl.obolibrary.org/obo/HP_0012381		
HP:0012382	biolink:PhenotypicFeature	Left-to-right shunt	Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from the left side of the heart to the right.	UMLS:C0428870|SNOMEDCT_US:66130006	hp.json		http://purl.obolibrary.org/obo/HP_0012382		
HP:0012383	biolink:PhenotypicFeature	Bidirectional shunt	Pattern of blood flow in the heart that deviates from the normal circuit of the circulatory system from both right side of the heart to the left and vice versa.	UMLS:C0428872|SNOMEDCT_US:13352000	hp.json		http://purl.obolibrary.org/obo/HP_0012383		
HP:0012384	biolink:PhenotypicFeature	Rhinitis	Inflammation of the nasal mucosa with nasal congestion.	UMLS:C2718128|SNOMEDCT_US:70076002|MSH:D012220|UMLS:C0035455	hp.json	Nasal inflammation	http://purl.obolibrary.org/obo/HP_0012384		hposlim_core
HP:0000396	biolink:PhenotypicFeature	Overfolded helix	A condition in which the helix is folded over to a greater degree than normal. That is, excessive curling of the helix edge, whereby the free edge is parallel to the plane of the ear.	UMLS:C1837731	hp.json	Over-folded helices|Overfolded ears|Overfolded helices	http://purl.obolibrary.org/obo/HP_0000396		hposlim_core
HP:0000395	biolink:PhenotypicFeature	Prominent antihelix	The presence of an abnormally prominent antihelix.	UMLS:C1845272	hp.json		http://purl.obolibrary.org/obo/HP_0000395		hposlim_core
HP:0000399	biolink:PhenotypicFeature	Prelingual sensorineural hearing impairment	A form of sensorineural deafness with either congenital onset or infantile onset, i.e., before the acquisition of speech.	UMLS:C4021806	hp.json	Prelingual sensorineural deafness|Deafness, sensorineural, prelingual	http://purl.obolibrary.org/obo/HP_0000399		
GO:0015698	biolink:BiologicalProcess	inorganic anion transport	The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.		hp.json		http://purl.obolibrary.org/obo/GO_0015698		
GO:0015695	biolink:BiologicalProcess	organic cation transport	The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.		hp.json		http://purl.obolibrary.org/obo/GO_0015695		
HP:0000391	biolink:PhenotypicFeature	Thickened helices	Increased thickness of the helix of the ear.	UMLS:C1837732	hp.json	Thick helix	http://purl.obolibrary.org/obo/HP_0000391		hposlim_core
HP:0000394	biolink:PhenotypicFeature	Lop ear	Anterior and inferior folding of the upper portion of the ear that obliterates triangular fossa and scapha.	SNOMEDCT_US:76223006|UMLS:C0266614	hp.json		http://purl.obolibrary.org/obo/HP_0000394		hposlim_core
HP:0012374	biolink:PhenotypicFeature	obsolete Abnormal globe morphology			hp.json		http://purl.obolibrary.org/obo/HP_0012374		
HP:0012375	biolink:PhenotypicFeature	Chemosis	Edema (swelling) of the bulbar conjunctiva.	SNOMEDCT_US:8148005|UMLS:C0271298	hp.json		http://purl.obolibrary.org/obo/HP_0012375		
HP:0012376	biolink:PhenotypicFeature	Microphakia	Abnormal smallness of the lens.	UMLS:C0266541|SNOMEDCT_US:35272001	hp.json	Small lens	http://purl.obolibrary.org/obo/HP_0012376		hposlim_core
HP:0012377	biolink:PhenotypicFeature	Hemianopia	Partial or complete loss of vision in one half of the visual field of one or both eyes.	MSH:D006423|SNOMEDCT_US:77674003|UMLS:C0018979	hp.json	Hemianopsia	http://purl.obolibrary.org/obo/HP_0012377		
HP:0012378	biolink:PhenotypicFeature	Fatigue	A subjective feeling of tiredness characterized by a lack of energy and motivation.	SNOMEDCT_US:84229001|MSH:D005221|UMLS:C0015672|SNOMEDCT_US:248274002	hp.json	Tiredness|Tired|Fatigue	http://purl.obolibrary.org/obo/HP_0012378		
HP:0012379	biolink:PhenotypicFeature	Abnormal enzyme/coenzyme activity	An altered ability of any enzyme or their cofactors to act as catalysts. This term includes changes due to altered levels of an enzyme.	UMLS:C4022922	hp.json		http://purl.obolibrary.org/obo/HP_0012379		
HP:0012370	biolink:PhenotypicFeature	Prominence of the zygomatic bone	Large or prominent malar surface of the zygomatic bone of the skull, which is convex and forms the prominence of the 'cheek bones'.	UMLS:C4082245|UMLS:C1997760|SNOMEDCT_US:427888001|UMLS:C0375511	hp.json	Prominence of cheekbone|Cheekbone prominence|Zygomatic bone excess|Malar hypertrophy|Zygomatic hypertrophy|Hyperplasia of cheekbone|Pronounced cheekbone|Hyperplasia of zygomatic bone|Cheekbone excess	http://purl.obolibrary.org/obo/HP_0012370		hposlim_core
HP:0012371	biolink:PhenotypicFeature	Hyperplasia of midface	Abnormally anterior positioning of the infraorbital and perialar regions, or increased convexity of the face, or increased nasolabial angle. The midface includes the maxilla, the cheeks, the zygomas, and the infraorbital and perialar regions of the face	UMLS:C0240309	hp.json	Midfacial excess|Midface hyperplasia|Hypertrophy of midface|Midfacial prominence|Big midface|Overgrowth of the midface|Large midface	http://purl.obolibrary.org/obo/HP_0012371		hposlim_core
HP:0012372	biolink:PhenotypicFeature	Abnormal eye morphology	A structural anomaly of the globe of the eye, or bulbus oculi.	UMLS:C4022925|Fyler:4863	hp.json	Abnormally shaped eye|Abnormal eye structure|Abnormality of the globe	http://purl.obolibrary.org/obo/HP_0012372		
HP:0012373	biolink:PhenotypicFeature	Abnormal eye physiology	A functional anomaly of the eye.	UMLS:C4022924	hp.json	Abnormal eye physiology	http://purl.obolibrary.org/obo/HP_0012373		
HP:0012363	biolink:PhenotypicFeature	Decreased sialylation of O-linked protein glycosylation	An reduced addition of sialic acids to O-linked glycans.	UMLS:C4022928	hp.json		http://purl.obolibrary.org/obo/HP_0012363		
HP:0012364	biolink:PhenotypicFeature	Decreased urinary potassium	A decreased concentration of potassium(1+) in the urine.	SNOMEDCT_US:54781007|UMLS:C0268024	hp.json	Hypokaluria|Low urine potassium levels|Hypokaliuria|Decreased urinary K	http://purl.obolibrary.org/obo/HP_0012364		
HP:0012365	biolink:PhenotypicFeature	Hypophosphaturia	An abnormally decreased phosphate concentration in the urine.	UMLS:C0268077|SNOMEDCT_US:91632005	hp.json	Low urine phosphate levels	http://purl.obolibrary.org/obo/HP_0012365		
HP:0012366	biolink:PhenotypicFeature	Basilar invagination	Projection of the tip of the dens more than 5 mm above a line joining the hard palate to the posterior lip of the foramen magnum (Chamberlain's line) or the tip of the dens is greater than 7 mm above McGregor's line (the back of the hard palate to the lowest point of the occipital squama).	UMLS:C3887851	hp.json		http://purl.obolibrary.org/obo/HP_0012366		
HP:0012367	biolink:PhenotypicFeature	Extra fontanelles	Bony defects situated along the cranial suture lines or at the junction of the bone plates of the skull.	UMLS:C4022927	hp.json		http://purl.obolibrary.org/obo/HP_0012367		hposlim_core
HP:0012368	biolink:PhenotypicFeature	Flat face	Absence of concavity or convexity of the face when viewed in profile.	UMLS:C1853241	hp.json	Flat facial profile|Flat facial shape|Flat face|Flat facies	http://purl.obolibrary.org/obo/HP_0012368		hposlim_core
HP:0012369	biolink:PhenotypicFeature	obsolete Abnormal malar bone morphology			hp.json		http://purl.obolibrary.org/obo/HP_0012369		
HP:0012360	biolink:PhenotypicFeature	Decreased fucosylation of O-linked protein glycosylation	A reduction of the addition of fucose sugar units to O-linked glycans.	UMLS:C4022931	hp.json		http://purl.obolibrary.org/obo/HP_0012360		
HP:0012361	biolink:PhenotypicFeature	Increased fucosylation of O-linked protein glycosylation	Increased addition of fucose sugar units to O-linked glycans.	UMLS:C4022930	hp.json		http://purl.obolibrary.org/obo/HP_0012361		
HP:0012362	biolink:PhenotypicFeature	Abnormal sialylation of O-linked protein glycosylation	An anomaly of the addition of sialic acids to O-linked glycans.	UMLS:C4022929	hp.json		http://purl.obolibrary.org/obo/HP_0012362		
HP:0000376	biolink:PhenotypicFeature	Incomplete partition of the cochlea type II	With incomplete partition II, the cochlea consists of 1.5 turns; the apical and middle cochlea turns are undifferentiated and form a cystic apex. The vestibule is normal while the vestibular aqueduct is always enlarged. Developmental arrest occurs at the seventh week of gestation.	UMLS:C4025857|UMLS:C1857078	hp.json	Mondini dysplasia|Mondini malformation|Mondini defect|Cochlear malformation defect (Mondini dysplasia)	http://purl.obolibrary.org/obo/HP_0000376		
HP:0000375	biolink:PhenotypicFeature	Abnormal cochlea morphology	An abnormality of the cochlea.	UMLS:C4025858	hp.json	Abnormality of cochlea	http://purl.obolibrary.org/obo/HP_0000375		
HP:0000378	biolink:PhenotypicFeature	Cupped ear	Laterally protruding ear that lacks antihelical folding (including absence of inferior and superior crura).	UMLS:C1845447|UMLS:C4020892	hp.json	Cupped ear|Capuchin ears|Simple, cup-shaped ears|Cupped ears|Cup-shaped ears	http://purl.obolibrary.org/obo/HP_0000378		hposlim_core
HP:0000377	biolink:PhenotypicFeature	Abnormal pinna morphology	An abnormality of the pinna, which is also referred to as the auricle or external ear.	SNOMEDCT_US:253255002|UMLS:C0431483|UMLS:C0857379	hp.json	Malformation of auricle|Deformed auricles|Minor malformation of the auricles|Malformed external ears|Dysplastic ears|Malformed ears|Malformed auricles|Abnormally shaped ears|Poorly defined conchae|Abnormal form of ears|Deformed ears|Auricular malformation	http://purl.obolibrary.org/obo/HP_0000377		
GO:0015671	biolink:BiologicalProcess	oxygen transport	The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0015671		
HP:0000370	biolink:PhenotypicFeature	Abnormality of the middle ear	An abnormality of the middle ear.	UMLS:C1861141	hp.json	Middle ear abnormality|Middle ear abnormalities	http://purl.obolibrary.org/obo/HP_0000370		hposlim_core
HP:0000372	biolink:PhenotypicFeature	Abnormality of the auditory canal	An abnormality of the External acoustic tube (also known as the auditory canal).	UMLS:C4021807	hp.json	Auditory canal abnormality	http://purl.obolibrary.org/obo/HP_0000372		
HP:0000371	biolink:PhenotypicFeature	Acute otitis media	Acute otitis media is a short and generally painful infection of the middle ear.	UMLS:C0271429|SNOMEDCT_US:3110003	hp.json	Acute middle ear infection	http://purl.obolibrary.org/obo/HP_0000371		
HP:0012352	biolink:PhenotypicFeature	Abnormal fucosylation of protein N-linked glycosylation	An anomaly of the addition of fucose sugar units to N-linked glycans.	UMLS:C4022939	hp.json		http://purl.obolibrary.org/obo/HP_0012352		
HP:0012353	biolink:PhenotypicFeature	Decreased fucosylation of N-linked protein glycosylation	Decreased addition of fucose sugar units to N-linked glycans.	UMLS:C4022938	hp.json		http://purl.obolibrary.org/obo/HP_0012353		
HP:0012354	biolink:PhenotypicFeature	Increased fucosylation of N-linked protein glycosylation	Increased addition of fucose sugar units to N-linked glycans.	UMLS:C4022937	hp.json		http://purl.obolibrary.org/obo/HP_0012354		
HP:0012355	biolink:PhenotypicFeature	Abnormal mannosylation of N-linked protein glycosylation	An anomaly of the addition of mannose to N-linked glycans.	UMLS:C4022936	hp.json		http://purl.obolibrary.org/obo/HP_0012355		
HP:0012356	biolink:PhenotypicFeature	Decreased mannosylation of N-linked protein glycosylation	Reduced addition of mannose to N-linked glycans.	UMLS:C4022935	hp.json		http://purl.obolibrary.org/obo/HP_0012356		
HP:0012357	biolink:PhenotypicFeature	Increased mannosylation of N-linked protein glycosylation	Increased addition of mannose to N-linked glycans.	UMLS:C4022934	hp.json		http://purl.obolibrary.org/obo/HP_0012357		
HP:0012358	biolink:PhenotypicFeature	Abnormal protein O-linked glycosylation	An anomaly of protein O-linked glycosylation, i.e., of the process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of a serine or threonine residue.	UMLS:C4022933	hp.json		http://purl.obolibrary.org/obo/HP_0012358		
HP:0012359	biolink:PhenotypicFeature	Abnormal fucosylation of O-linked protein glycosylation	An anomaly of the addition of fucose sugar units to O-linked glycans.	UMLS:C4022932	hp.json		http://purl.obolibrary.org/obo/HP_0012359		
CHEBI:146306	biolink:ChemicalSubstance	partially-defined glycan	A member of the class of carbohydrates and carbohydrate derivatives that is any oligosaccharide or polysaccharide in which the identity of one or more of the individual monosaccharide units, their connectivity (position of attachment) or the stereochemistry (alpha- or beta-) of one or more of the glycosidic linkages is not known.		hp.json	partially defined glycan|partially-defined glycans|partially defined glycans	http://purl.obolibrary.org/obo/CHEBI_146306		3_STAR
HP:0012350	biolink:PhenotypicFeature	Decreased sialylation of N-linked protein glycosylation	Decreased addition of sialic acids to N-linked glycans.	UMLS:C4022941	hp.json		http://purl.obolibrary.org/obo/HP_0012350		
HP:0012351	biolink:PhenotypicFeature	Increased sialylation of N-linked protein glycosylation	Increased addition of sialic acids to N-linked glycans.	UMLS:C4022940	hp.json		http://purl.obolibrary.org/obo/HP_0012351		
HP:0000385	biolink:PhenotypicFeature	Small earlobe	Reduced volume of the earlobe.	UMLS:C1842680	hp.json	Small earlobe|Hypoplastic earlobes|Hypoplastic lobules|Small earlobes	http://purl.obolibrary.org/obo/HP_0000385		hposlim_core
HP:0000384	biolink:PhenotypicFeature	Preauricular skin tag	A rudimentary tag of skin often containing ear tissue including a core of cartilage and located just anterior to the auricle (outer part of the ear).	UMLS:C1860816|UMLS:C4072826	hp.json	Skin tag on the posterior cheek|Preauricular skin tags|Preauricular tag|Ear tag|Periauricular skin tag|Skin tag in front of the ear|Preauricular acrochordon|Preauricular fibroepithelial polyp|Preauricular tags	http://purl.obolibrary.org/obo/HP_0000384		
HP:0000387	biolink:PhenotypicFeature	Absent earlobe	Absence of fleshy non-cartilaginous tissue inferior to the tragus and incisura.	UMLS:C1849364	hp.json	Absent ear lobes|Absent earlobe|Lobule aplasia|Lobeless ears|Earlobe, absent	http://purl.obolibrary.org/obo/HP_0000387		hposlim_core
HP:0000389	biolink:PhenotypicFeature	Chronic otitis media	Chronic otitis media refers to fluid, swelling, or infection of the middle ear that does not heal and may cause permanent damage to the ear.	SNOMEDCT_US:21186006|UMLS:C0743359|UMLS:C0271441	hp.json	Chronic middle ear infection|Chronic ear infection|Chronic infections of the middle ear|Otitis media, chronic	http://purl.obolibrary.org/obo/HP_0000389		hposlim_core
HP:0000388	biolink:PhenotypicFeature	Otitis media	Inflammation or infection of the middle ear.	SNOMEDCT_US:65363002|UMLS:C0029882|MSH:D010033	hp.json	Middle ear infection	http://purl.obolibrary.org/obo/HP_0000388		
HP:0000381	biolink:PhenotypicFeature	Stapes ankylosis	Stapes ankylosis refers to congenital or acquired fixation of the stapes (the stirrup-shaped small bone or ossicle in the middle ear), which is associated with conductive hearing resulting from impairment of the sound-conduction mechanism (the external auditory canal, tympanic membrane, and/or middle-ear ossicles).	UMLS:C1861326	hp.json	Stapes fixation	http://purl.obolibrary.org/obo/HP_0000381		hposlim_core
HP:0000383	biolink:PhenotypicFeature	Abnormal periauricular region morphology		UMLS:C4025856	hp.json	Anomaly of the periauricular region|Malformation of the periauricular region|Deformity of the periauricular region|Abnormality of periauricular region|Abnormality of the region around the ear	http://purl.obolibrary.org/obo/HP_0000383		
BFO:0000141	biolink:NamedThing	immaterial entity			hp.json		http://purl.obolibrary.org/obo/BFO_0000141		
HP:0012500	biolink:PhenotypicFeature	Verrucous papule	A wartlike (with multiple small elevated projections) papule.	UMLS:C4022877	hp.json	Papillomatous papule	http://purl.obolibrary.org/obo/HP_0012500		
HP:0012501	biolink:PhenotypicFeature	Abnormal brainstem white matter morphology	An anomaly of the white matter of brainstem.	UMLS:C4022876	hp.json	Abnormality of the brainstem white matter	http://purl.obolibrary.org/obo/HP_0012501		
HP:0012502	biolink:PhenotypicFeature	Abnormality of the internal capsule	An anomaly of the internal capsule, which is an area of white matter in the brain that separates the caudate nucleus and the thalamus from the putamen and the globus pallidus.	UMLS:C4022875	hp.json		http://purl.obolibrary.org/obo/HP_0012502		
HP:0000514	biolink:PhenotypicFeature	Slow saccadic eye movements	An abnormally slow velocity of the saccadic eye movements.	UMLS:C1321329|SNOMEDCT_US:404686001	hp.json	Slow eye movements|Slow saccades|Slow visual tracking	http://purl.obolibrary.org/obo/HP_0000514		hposlim_core
HP:0000518	biolink:PhenotypicFeature	Cataract	A cataract is an opacity or clouding that develops in the crystalline lens of the eye or in its capsule.	SNOMEDCT_US:128306009|SNOMEDCT_US:193570009|UMLS:C0086543|MSH:D002386|SNOMEDCT_US:247053007|Fyler:4865|UMLS:C1510497	hp.json	Cloudy lens|Clouding of the lens of the eye|Lens opacity|Cataracts|Lens opacities	http://purl.obolibrary.org/obo/HP_0000518		hposlim_core
HP:0000517	biolink:PhenotypicFeature	Abnormal lens morphology	An abnormality of the lens.	UMLS:C0023308|UMLS:C0549651|SNOMEDCT_US:10810001|MSH:D007905	hp.json	Abnormality of the lens|Lens issue|Lens disease	http://purl.obolibrary.org/obo/HP_0000517		
HP:0000519	biolink:PhenotypicFeature	Developmental cataract	A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens.	UMLS:C0009691|UMLS:C3277059|SNOMEDCT_US:609587005|SNOMEDCT_US:79410001	hp.json	Cataract, congenital|Congenital cataracts, bilateral|Congenital cataracts|Bilateral congenital cataracts|Clouding of the lens of the eye at birth|Congenital cataract	http://purl.obolibrary.org/obo/HP_0000519		hposlim_core
HP:0000510	biolink:PhenotypicFeature	Rod-cone dystrophy	An inherited retinal disease subtype in which the rod photoreceptors appear to be more severely affected than the cone photoreceptors. Typical presentation is with nyctalopia (due to rod dysfunction) followed by loss of mid-peripheral field of vision, which gradually extends and leaves many patients with a small central island of vision due to the preservation of macular cones.	SNOMEDCT_US:28835009|UMLS:C0035334|MSH:D012174	hp.json	Rod cone dystrophy|Retinitis pigmentosa	http://purl.obolibrary.org/obo/HP_0000510		hposlim_core
HP:0000512	biolink:PhenotypicFeature	Abnormal electroretinogram	Any abnormality of the electrical responses of various cell types in the retina as measured by electroretinography.	UMLS:C0476397|SNOMEDCT_US:274524001	hp.json	Abnormal ERG|ERG abnormal|Abnormal electroretinography	http://purl.obolibrary.org/obo/HP_0000512		hposlim_core
HP:0000511	biolink:PhenotypicFeature	Vertical supranuclear gaze palsy	A supranuclear gaze palsy is an inability to look in a vertical direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal.	SNOMEDCT_US:246773002|UMLS:C1843369|UMLS:C0339652	hp.json	Vertical gaze palsy	http://purl.obolibrary.org/obo/HP_0000511		
HP:0012503	biolink:PhenotypicFeature	Abnormality of the pituitary gland	An anomaly of the pituitary gland.	SNOMEDCT_US:399244003|UMLS:C0032002|MSH:D010900	hp.json	disorder of pituitary gland	http://purl.obolibrary.org/obo/HP_0012503		
HP:0012504	biolink:PhenotypicFeature	Abnormal size of pituitary gland	A deviation from the normal size of the pituitary gland.	UMLS:C4022874	hp.json		http://purl.obolibrary.org/obo/HP_0012504		
HP:0012505	biolink:PhenotypicFeature	Enlarged pituitary gland	An abnormally increased size of the pituitary gland.	UMLS:C0342422|SNOMEDCT_US:237718009	hp.json		http://purl.obolibrary.org/obo/HP_0012505		
HP:0012506	biolink:PhenotypicFeature	Small pituitary gland	An abnormally decreased size of the pituitary gland.	UMLS:C4022873	hp.json		http://purl.obolibrary.org/obo/HP_0012506		
HP:0012507	biolink:PhenotypicFeature	Weakness of orbicularis oculi muscle	Reduced strength of the orbicularis oculi, the circumorbital muscle in the face that closes the eyelid.	UMLS:C1839030	hp.json	Weakness of orbicularis oculi muscles	http://purl.obolibrary.org/obo/HP_0012507		
HP:0012508	biolink:PhenotypicFeature	Metamorphopsia	A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank.	MSH:D014786|UMLS:C0271185|SNOMEDCT_US:42134006	hp.json		http://purl.obolibrary.org/obo/HP_0012508		
HP:0012509	biolink:PhenotypicFeature	Reduced thyroxin-binding globulin	An abnormally decreased amount of thyroxin-binding globulin (TBG) in blood. TBG is responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream.	UMLS:C4022872	hp.json		http://purl.obolibrary.org/obo/HP_0012509		
HP:0000525	biolink:PhenotypicFeature	Abnormality iris morphology	An abnormality of the iris, which is the pigmented muscular tissue between the cornea and the lens, that is perforated by an opening called the pupil.	UMLS:C4025845	hp.json	Abnormality of the iris	http://purl.obolibrary.org/obo/HP_0000525		hposlim_core
HP:0000524	biolink:PhenotypicFeature	Conjunctival telangiectasia	The presence of small (ca. 0.5-1.0 mm) dilated blood vessels near the surface of the mucous membranes of the conjunctiva.	UMLS:C0239105|SNOMEDCT_US:231870008	hp.json	Small dilated blood vessels near membrane covering front of eye and eyelids|Telangiectasia, conjunctival|Conjunctival telangiectases	http://purl.obolibrary.org/obo/HP_0000524		hposlim_core
HP:0000527	biolink:PhenotypicFeature	Long eyelashes	Mid upper eyelash length >10 mm or increased length of the eyelashes (subjective).	UMLS:C1853738	hp.json	Long eyelashes|Ciliary trichomegaly|Unusually long eyelashes|Increased length of eyelashes|Eyelash trichomegaly	http://purl.obolibrary.org/obo/HP_0000527		hposlim_core
HP:0000526	biolink:PhenotypicFeature	Aniridia	Abnormality of the iris characterized by, typically bilateral, complete or partial iris hypoplasia. The phenotype ranges from mild defects of anterior iris stroma only to almost complete absence of the iris.	MSH:D015783|SNOMEDCT_US:69278003|UMLS:C0003076	hp.json	Absent iris	http://purl.obolibrary.org/obo/HP_0000526		hposlim_core
HP:0000529	biolink:PhenotypicFeature	Progressive visual loss	A reduction of previously attained ability to see.	UMLS:C3277697|UMLS:C1839364	hp.json	Slowly progressive visual loss|Decreased visual acuity, progressive|Loss of visual acuity|Progressive loss of vision|Vision loss, progressive|Progressive visual acuity loss|Progressive visual impairment|Progressive vision loss|Visual loss, progressive	http://purl.obolibrary.org/obo/HP_0000529		hposlim_core
HP:0000528	biolink:PhenotypicFeature	Anophthalmia	Absence of the globe or eyeball.	UMLS:C0003119|SNOMEDCT_US:7183006|Fyler:4864|SNOMEDCT_US:204099004|MSH:D000853	hp.json	Missing globe of eye|Missing eyeball|Absence of globes of eyes|Absence of eyeballs|No eyeball|No globe of eye|Failure of development of eyeball|Ocular absence|Clinical anophthalmia, unilateral/bilateral|Anophthalmia, clinical	http://purl.obolibrary.org/obo/HP_0000528		hposlim_core
HP:0000520	biolink:PhenotypicFeature	Proptosis	An eye that is protruding anterior to the plane of the face to a greater extent than is typical.	UMLS:C1862425|UMLS:C1848490|UMLS:C0015300|SNOMEDCT_US:18265008|MSH:D005094|UMLS:C1837760	hp.json	Protrusio bulbi|Anterior bulging of the globe of eye|Exophthalmos|Eyeballs bulging out|Bulging eye|Ocular proptosis|Anterior bulging of the globe|Prominent globes|Prominent eyes|Protruding eyes	http://purl.obolibrary.org/obo/HP_0000520		hposlim_core
HP:0000523	biolink:PhenotypicFeature	Subcapsular cataract	A cataract that affects the region of the lens directly beneath the capsule of the lens.	UMLS:C0235259|SNOMEDCT_US:95723009	hp.json	Subcapsular lenticular cataracts|Subcapsular opacities|Subcapsular cataracts	http://purl.obolibrary.org/obo/HP_0000523		
HP:0000522	biolink:PhenotypicFeature	Alacrima	Absence of tear secretion.	SNOMEDCT_US:253215004|MSH:C562827|UMLS:C0344505	hp.json	Absent lacrimal fluids|Absent tear secretion|Absence of tears in the eyes	http://purl.obolibrary.org/obo/HP_0000522		hposlim_core
HP:0000503	biolink:PhenotypicFeature	Tortuosity of conjunctival vessels	The presence of an increased number of twists and turns of the conjunctival blood vessels.	UMLS:C1855391	hp.json		http://purl.obolibrary.org/obo/HP_0000503		
HP:0000502	biolink:PhenotypicFeature	Abnormal conjunctiva morphology	An abnormality of the conjunctiva.	UMLS:C4025847	hp.json		http://purl.obolibrary.org/obo/HP_0000502		hposlim_core
HP:0000505	biolink:PhenotypicFeature	Visual impairment	Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery.	UMLS:C0042798|MSH:D014786|SNOMEDCT_US:246635007|SNOMEDCT_US:397540003|UMLS:C3665347|MSH:D015354|SNOMEDCT_US:7973008	hp.json	Visual impairment|Impaired vision|Loss of eyesight|Poor vision	http://purl.obolibrary.org/obo/HP_0000505		hposlim_core
HP:0000504	biolink:PhenotypicFeature	Abnormality of vision	Abnormality of eyesight (visual perception).	UMLS:C4025846	hp.json	Abnormality of vision|Abnormality of sight|Vision issue	http://purl.obolibrary.org/obo/HP_0000504		hposlim_core
HP:0000506	biolink:PhenotypicFeature	Telecanthus	Distance between the inner canthi more than two standard deviations above the mean (objective); or, apparently increased distance between the inner canthi.	MSH:C562941|SNOMEDCT_US:246803005|UMLS:C0423113	hp.json	Increased distance between medial canthi|Dystopia canthorum|Corners of eye widely separated|Increased intercanthal distance	http://purl.obolibrary.org/obo/HP_0000506		hposlim_core
HP:0000509	biolink:PhenotypicFeature	Conjunctivitis	Inflammation of the conjunctiva.	UMLS:C1864156|UMLS:C0009763|SNOMEDCT_US:9826008|MSH:D003231	hp.json	Pink eye|Conjunctivitis, recurrent	http://purl.obolibrary.org/obo/HP_0000509		hposlim_core
HP:0000508	biolink:PhenotypicFeature	Ptosis	The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective).	MSH:D001763|SNOMEDCT_US:11934000|UMLS:C0005745	hp.json	Eye drop|Blepharoptosis|Drooping upper eyelid|Eyelid ptosis	http://purl.obolibrary.org/obo/HP_0000508		hposlim_core
HP:0000501	biolink:PhenotypicFeature	Glaucoma	Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure.	SNOMEDCT_US:23986001|MSH:D005901|UMLS:C0017601	hp.json		http://purl.obolibrary.org/obo/HP_0000501		hposlim_core
HP:0012540	biolink:PhenotypicFeature	Axillary epidermoid cyst	An epidermoid cyst in the armpit.	UMLS:C4022859	hp.json	Armpit cyst	http://purl.obolibrary.org/obo/HP_0012540		
HP:0012541	biolink:PhenotypicFeature	Cephalohematoma	Hemorrhage between the skull and periosteum of a newborn resulting from rupture of blood vessels that cross the periosteum.	UMLS:C0007722|SNOMEDCT_US:83095000|SNOMEDCT_US:206200000	hp.json	Cephalohaematoma	http://purl.obolibrary.org/obo/HP_0012541		
HP:0012542	biolink:PhenotypicFeature	Onychauxis	Thickened nails without deformity.	UMLS:C0263536|SNOMEDCT_US:30654002	hp.json		http://purl.obolibrary.org/obo/HP_0012542		
HP:0012543	biolink:PhenotypicFeature	Hemosiderinuria	The presence of hemosiderin in the urine.	UMLS:C2721579	hp.json		http://purl.obolibrary.org/obo/HP_0012543		
HP:0012544	biolink:PhenotypicFeature	Elevated aldolase level	An increased concentration of fructose 1,6-bisphosphate aldolase in the serum.	UMLS:C4022858	hp.json		http://purl.obolibrary.org/obo/HP_0012544		
HP:0012545	biolink:PhenotypicFeature	Reduced aldolase level	An decreased concentration of fructose 1,6-bisphosphate aldolase in the serum.	UMLS:C4022857	hp.json		http://purl.obolibrary.org/obo/HP_0012545		
HP:0012546	biolink:PhenotypicFeature	Skewed maternal X inactivation	A deviation from equal (50%) inactivation of each parental X chromosome in maternal cells.	UMLS:C4022856	hp.json		http://purl.obolibrary.org/obo/HP_0012546		
HP:0000558	biolink:PhenotypicFeature	Rieger anomaly	A congenital malformation of the anterior segment characterized by iridicorneal malformation, glaucoma, iris stroma hypoplasia, posterior embryotoxon, and corneal opacities.	UMLS:C0265341|SNOMEDCT_US:47507006|MSH:C535679	hp.json		http://purl.obolibrary.org/obo/HP_0000558		
HP:0000557	biolink:PhenotypicFeature	Buphthalmos	Diffusely large eye (with megalocornea) associated with glaucoma.	MSH:D006871|UMLS:C4551507	hp.json	Enlarged eyeball	http://purl.obolibrary.org/obo/HP_0000557		hposlim_core
HP:0000559	biolink:PhenotypicFeature	Corneal scarring		UMLS:C0349702|SNOMEDCT_US:95726001|MSH:D065306	hp.json		http://purl.obolibrary.org/obo/HP_0000559		
HP:0000550	biolink:PhenotypicFeature	Undetectable electroretinogram	Lack of any response to stimulation upon electroretinography.	UMLS:C1855685	hp.json	Absent electroretinogram|Extinguished electroretinogram|Extinction of electroretinogram|Undetectable ERG|No light-evoked response on electroretinogram|Abolished electroretinogram	http://purl.obolibrary.org/obo/HP_0000550		
HP:0000552	biolink:PhenotypicFeature	Tritanomaly	Difficulty distinguishing between yellow and blue, possible related to dysfunction of the S photopigment.	UMLS:C1970167|SNOMEDCT_US:85049009|SNOMEDCT_US:51886007|MSH:D003117|UMLS:C0155017	hp.json	Dyschromatopsia, blue-yellow|Blue/yellow colour vision defect|Blue yellow color blindness|Blue-yellow dyschromatopsia|Blue/yellow color vision defect|Blue yellow colour blindness	http://purl.obolibrary.org/obo/HP_0000552		
HP:0000551	biolink:PhenotypicFeature	Color vision defect	An anomaly in the ability to discriminate between or recognize colors.	SNOMEDCT_US:367469000|SNOMEDCT_US:23289000|UMLS:C0234629|UMLS:C0009398|MSH:D003117|UMLS:C3552853	hp.json	Colour vision defects|Loss in colour vision|Colour vision defect, severe|Disturbed color vision|Colour vision defect|Abnormal colour vision|Abnormal color vision|Color vision defects|Color vision defect, severe|Loss in color vision|Abnormality of colour vision|Abnormality of color vision	http://purl.obolibrary.org/obo/HP_0000551		
HP:0000554	biolink:PhenotypicFeature	Uveitis	Inflammation of one or all portions of the uveal tract.	UMLS:C0042164|MSH:D014605|SNOMEDCT_US:128473001	hp.json		http://purl.obolibrary.org/obo/HP_0000554		hposlim_core
HP:0000553	biolink:PhenotypicFeature	Abnormal uvea morphology	An abnormality of the uvea, the vascular layer of the eyeball.	UMLS:C4025842	hp.json	Abnormality of the uvea	http://purl.obolibrary.org/obo/HP_0000553		
HP:0000556	biolink:PhenotypicFeature	Retinal dystrophy	Retinal dystrophy is an abnormality of the retina associated with a hereditary process. Retinal dystrophies are defined by their predominantly monogenic inheritance and they are frequently associated with loss or dysfunction of photoreceptor cells as a primary or secondary event.	SNOMEDCT_US:314407005|UMLS:C0854723|MSH:D058499	hp.json	Breakdown of light-sensitive cells in back of eye	http://purl.obolibrary.org/obo/HP_0000556		
HP:0000555	biolink:PhenotypicFeature	Leukocoria	An abnormal white reflection from the pupil rather than the usual black reflection.	SNOMEDCT_US:1361009|UMLS:C0152458	hp.json	White pupillary reflex|Leukokoria	http://purl.obolibrary.org/obo/HP_0000555		
HP:0012547	biolink:PhenotypicFeature	Abnormal involuntary eye movements	Anomalous movements of the eyes that occur without the subject wanting them to happen.	UMLS:C4022855	hp.json		http://purl.obolibrary.org/obo/HP_0012547		
HP:0012548	biolink:PhenotypicFeature	Fatty replacement of skeletal muscle	Muscle fibers degeneration resulting in fatty replacement of skeletal muscle fibers	UMLS:C4021082	hp.json	Skeletal muscle fatty infiltration	http://purl.obolibrary.org/obo/HP_0012548		
HP:0012549	biolink:PhenotypicFeature	Conjunctival lipoma	A lipoma (a benign tumor composed of adipose tissue) located in the conjunctiva.	UMLS:C4022854|NCIT:C3192	hp.json		http://purl.obolibrary.org/obo/HP_0012549		
HP:0012530	biolink:PhenotypicFeature	Abnormal number of dense granules	A deviation from the normal count of dense granules per thrombocyte.	UMLS:C4022861	hp.json		http://purl.obolibrary.org/obo/HP_0012530		
HP:0012531	biolink:PhenotypicFeature	Pain	An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage.	SNOMEDCT_US:22253000|UMLS:C0030193|MSH:D010146	hp.json	Pain	http://purl.obolibrary.org/obo/HP_0012531		
HP:0012532	biolink:PhenotypicFeature	Chronic pain	Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months.	MSH:D059350|UMLS:C0150055|SNOMEDCT_US:82423001	hp.json	Chronic pain|Long-lasting pain	http://purl.obolibrary.org/obo/HP_0012532		
HP:0012533	biolink:PhenotypicFeature	Allodynia	Pain due to a stimulus that does not normally provoke pain.	UMLS:C0458247|MSH:D006930|SNOMEDCT_US:247404004	hp.json		http://purl.obolibrary.org/obo/HP_0012533		
HP:0012534	biolink:PhenotypicFeature	Dysesthesia	Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds.	MSH:D010292|UMLS:C0392699|SNOMEDCT_US:279079003	hp.json	Dysaesthesia|Hyperpathia|Dysesthesias|Hyperalgesia	http://purl.obolibrary.org/obo/HP_0012534		
HP:0012535	biolink:PhenotypicFeature	Abnormal synaptic transmission	An anomaly in the communication from a neuron to a target across a synapse. This is a four step process, comprising (i) synthesis and storage of neurotransmitters; (ii) neurotransmitter release; (iii) activation of postsynaptic receptors by the neurotransmitter; and (iv) inactivation of the neurotransmitter. Thus, this term is defined as an anomaly of neurotransmitter metabolic process.	UMLS:C4021083	hp.json	Abnormality of neurotransmitter metabolism	http://purl.obolibrary.org/obo/HP_0012535		
HP:0000568	biolink:PhenotypicFeature	Microphthalmia	A developmental anomaly characterized by abnormal smallness of one or both eyes.	Fyler:4877|MSH:D008850|SNOMEDCT_US:204108000|SNOMEDCT_US:61142002|UMLS:C0026010|UMLS:C4280808|UMLS:C4280625	hp.json	Abnormally small globe of eye|Decreased size of eyeball|Microphthalmos|Abnormally small eyeball|Nanophthalmos|Decreased size of globe of eye	http://purl.obolibrary.org/obo/HP_0000568		hposlim_core
HP:0000561	biolink:PhenotypicFeature	Absent eyelashes	Lack of eyelashes.	UMLS:C4280627|UMLS:C4280626|UMLS:C1843005	hp.json	Failure of development of eyelashes|Absent eyelashes|Agenesis of eyelashes|Aplasia of eyelashes|Atrichia of eyelashes	http://purl.obolibrary.org/obo/HP_0000561		hposlim_core
HP:0000563	biolink:PhenotypicFeature	Keratoconus	A cone-shaped deformity of the cornea characterized by the presence of corneal distortion secondary to thinning of the apex.	MSH:D007640|SNOMEDCT_US:65636009|UMLS:C0022578	hp.json	Conical cornea|Bulging cornea	http://purl.obolibrary.org/obo/HP_0000563		hposlim_core
HP:0000565	biolink:PhenotypicFeature	Esotropia	A form of strabismus with one or both eyes turned inward ('crossed') to a relatively severe degree, usually defined as 10 diopters or more.	MSH:D004948|SNOMEDCT_US:16596007|UMLS:C0014877	hp.json	Inward turning cross eyed	http://purl.obolibrary.org/obo/HP_0000565		hposlim_core
HP:0000564	biolink:PhenotypicFeature	Lacrimal duct atresia	A developmental disorder of the lacrimal drainage system that most often affects the lacrimal ostium and resulting in non-opening of the nasolacrimal duct. It usually results from a non-canalization of the nasolacrimal duct.	SNOMEDCT_US:278530008|UMLS:C0344511	hp.json	Nasolacrimal duct atresia|Imperforate nasolacrimal ducts|Unopened tear duct	http://purl.obolibrary.org/obo/HP_0000564		
HP:0000567	biolink:PhenotypicFeature	Chorioretinal coloboma	Absence of a region of the retina, retinal pigment epithelium, and choroid.	SNOMEDCT_US:39302008|UMLS:C0240896	hp.json	Birth defect that causes a hole in the innermost layer at the back of the eye|Choroid coloboma|Coloboma of choroid|Choroidal coloboma|Choroidoretinal coloboma	http://purl.obolibrary.org/obo/HP_0000567		
HP:0012536	biolink:PhenotypicFeature	Maternal anticardiolipin antibody positive	The presence of circulating autoantibodies to anticardiolipin in the mother.	UMLS:C4022860	hp.json		http://purl.obolibrary.org/obo/HP_0012536		
HP:0012537	biolink:PhenotypicFeature	Food intolerance	A detrimental reaction to a food, beverage, food additive, or compound found in foods that produces symptoms in one or more body organs and systems that is not mediated by an immune reaction.	UMLS:C0149696|SNOMEDCT_US:235719002	hp.json	Food intolerance|Non-allergic food hypersensitivity	http://purl.obolibrary.org/obo/HP_0012537		
HP:0012538	biolink:PhenotypicFeature	Gluten intolerance	A detrimental reaction to the presence of gluten in food, which may include abdominal pain, fatigue, headaches and paresthesia, or celiac disease.	SNOMEDCT_US:441831003|UMLS:C0850024|MSH:D002446|UMLS:C0007570|SNOMEDCT_US:396331005	hp.json	Gluten intolerance|Gluten sensitivity	http://purl.obolibrary.org/obo/HP_0012538		
HP:0012539	biolink:PhenotypicFeature	Non-Hodgkin lymphoma	A type of lymphoma characterized microscopically by the absence of multinucleated Reed-Sternberg cells.	MSH:D008228|SNOMEDCT_US:128929007|SNOMEDCT_US:118601006|SNOMEDCT_US:1929004|UMLS:C0024305|SNOMEDCT_US:188675007	hp.json		http://purl.obolibrary.org/obo/HP_0012539		
HP:0012520	biolink:PhenotypicFeature	Dilation of Virchow-Robin spaces	Increased dimensions of the Virchow-Robin spaces (also known as perivascular spaces), which surround the walls of vessels as they course from the subarachnoid space through the brain parenchyma. Perivascular spaces are commonly microscopic, and not visible on conventional neuroimaging. This term refers to an increase of size of these spaces such that they are visible on neuroimaging (usually magnetic resonance imaging). The dilatations are regular cavities that always contain a patent artery.	UMLS:C1853618|UMLS:C4020719	hp.json	Dilated Virchow-Robin spaces|Dilated cerebral perivascular spaces|Perivascular spaces	http://purl.obolibrary.org/obo/HP_0012520		
HP:0012521	biolink:PhenotypicFeature	Optic nerve aplasia	Congenital absence of the optic nerve.	UMLS:C4021084	hp.json	Absent optic nerve|Aplastic optic nerve	http://purl.obolibrary.org/obo/HP_0012521		
HP:0012522	biolink:PhenotypicFeature	Spider hemangioma	A form of telangiectasis characterized by a central elevated red dot the size of a pinhead, representing an arteriole, with numerous small blood vessels that radiate out thereby resembling the legs of a spider. Characteristically, compression of the central arteriole causes the entire lesion to blanch, and the lesion quickly refills once the compression is released.	UMLS:C4022867	hp.json		http://purl.obolibrary.org/obo/HP_0012522		
HP:0012523	biolink:PhenotypicFeature	Oral aversion	Reluctance or refusal of a child to be breastfed or eat, manifested as gagging, vomiting, turning head away from food, or avoidance of sensation in or around the mouth (i.e. toothbrushing or face-washing).	UMLS:C3665983	hp.json		http://purl.obolibrary.org/obo/HP_0012523		
HP:0012524	biolink:PhenotypicFeature	Abnormal platelet shape	A deviation from the normal discoid platelet shape.	UMLS:C4022866	hp.json		http://purl.obolibrary.org/obo/HP_0012524		
OBO:uberon/core#channels_from	biolink:NamedThing	channels_from			hp.json		http://purl.obolibrary.org/obo/uberon/core#channels_from		
HP:0000535	biolink:PhenotypicFeature	obsolete Sparse and thin eyebrow			hp.json		http://purl.obolibrary.org/obo/HP_0000535		
HP:0000538	biolink:PhenotypicFeature	Pseudopapilledema	Apparent optic disc swelling in the absence of increased intracranial pressure.	MSH:C562401|SNOMEDCT_US:57138009|UMLS:C0155300	hp.json		http://purl.obolibrary.org/obo/HP_0000538		hposlim_core
HP:0000537	biolink:PhenotypicFeature	Epicanthus inversus	A fold of skin starting at or just below the medial aspect of the lower lid and arching upward to cover, extend in front of and lateral to the medial canthus.	UMLS:C1303003|SNOMEDCT_US:400956000	hp.json		http://purl.obolibrary.org/obo/HP_0000537		hposlim_core
HP:0000539	biolink:PhenotypicFeature	Abnormality of refraction	An abnormality in the process of focusing of light by the eye in order to produce a sharp image on the retina.	UMLS:C4025843	hp.json		http://purl.obolibrary.org/obo/HP_0000539		
HP:0000532	biolink:PhenotypicFeature	Abnormal chorioretinal morphology	An abnormality of the choroid and retina.	UMLS:C4025844	hp.json	Chorioretinal abnormality	http://purl.obolibrary.org/obo/HP_0000532		
HP:0000531	biolink:PhenotypicFeature	Corneal crystals		UMLS:C1096610	hp.json	Corneal deposits	http://purl.obolibrary.org/obo/HP_0000531		
HP:0000534	biolink:PhenotypicFeature	Abnormal eyebrow morphology	An abnormality of the eyebrow.	UMLS:C4011556	hp.json	Abnormality of the eyebrow	http://purl.obolibrary.org/obo/HP_0000534		hposlim_core
HP:0000533	biolink:PhenotypicFeature	Chorioretinal atrophy	Atrophy of the choroid and retinal layers of the fundus.	UMLS:C4048273|SNOMEDCT_US:95686007	hp.json	Chorioretinal thinning	http://purl.obolibrary.org/obo/HP_0000533		
HP:0012525	biolink:PhenotypicFeature	Abnormal alpha granule distribution	An anomalous location and arrangement of platelet alpha granules.	UMLS:C4022865	hp.json		http://purl.obolibrary.org/obo/HP_0012525		
HP:0012526	biolink:PhenotypicFeature	Absence of alpha granules	A lack of platelet alpha granules. This typically results in the grey appearance of platelets in giemsa stained blood smears.	UMLS:C4022864	hp.json	Grey platelets|Gray platelets	http://purl.obolibrary.org/obo/HP_0012526		
HP:0012527	biolink:PhenotypicFeature	Abnormal alpha granule content	A deviation from the normal contents of the platelet alpha granules, which normally contain hemostatic proteins such as fibrinogen, von Willebrand factor, and growth factors such as platelet-derived growth factor.	UMLS:C4022863	hp.json		http://purl.obolibrary.org/obo/HP_0012527		
HP:0012528	biolink:PhenotypicFeature	Abnormal number of alpha granules	A deviation from the normal count of alpha granules per thrombocyte.	UMLS:C4022862	hp.json		http://purl.obolibrary.org/obo/HP_0012528		
HP:0012529	biolink:PhenotypicFeature	Abnormal dense granule content	A deviation from the normal contents of the platelet alpha granules, which normally contain adenosine triphosphate (ATP), adenosine diphosphate (ADP), serotonin, calcium, and pyrophosphate, which are secreted when platelets are activated.	UMLS:C4021839	hp.json		http://purl.obolibrary.org/obo/HP_0012529		
HP:0012510	biolink:PhenotypicFeature	Extra-axial cerebrospinal fluid accumulation	An increased amount of cerebrospinal fluid (CSF) in the subarachnoid space.	UMLS:C4022871	hp.json	Extra-axial CSF accumulation	http://purl.obolibrary.org/obo/HP_0012510		
HP:0012511	biolink:PhenotypicFeature	Temporal optic disc pallor	A pale yellow discoloration of the temporal (lateral) portion of the optic disc.	UMLS:C0344299|SNOMEDCT_US:247220006	hp.json		http://purl.obolibrary.org/obo/HP_0012511		
HP:0012512	biolink:PhenotypicFeature	Diffuse optic disc pallor	A pale yellow discoloration of the entire optic disc.	UMLS:C4022870	hp.json		http://purl.obolibrary.org/obo/HP_0012512		
HP:0012513	biolink:PhenotypicFeature	Upper limb pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the arm.	SNOMEDCT_US:102556003|UMLS:C0239377	hp.json	Upper limb pain	http://purl.obolibrary.org/obo/HP_0012513		
HP:0000547	biolink:PhenotypicFeature	obsolete Tapetoretinal degeneration			hp.json	Retinotapetal degeneration	http://purl.obolibrary.org/obo/HP_0000547		
HP:0000546	biolink:PhenotypicFeature	Retinal degeneration	A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells.	MSH:D012162|SNOMEDCT_US:95695004|UMLS:C0035304	hp.json	Retina degeneration	http://purl.obolibrary.org/obo/HP_0000546		hposlim_core
HP:0000549	biolink:PhenotypicFeature	Abnormal conjugate eye movement	Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object.	UMLS:C1845274	hp.json	Disconjugate eye movements	http://purl.obolibrary.org/obo/HP_0000549		
HP:0000548	biolink:PhenotypicFeature	Cone/cone-rod dystrophy		MSH:D012174	hp.json	Cone-rod retinal dystrophy|Cone rod dystrophy	http://purl.obolibrary.org/obo/HP_0000548		
CHEBI:8504	biolink:ChemicalSubstance	prostanoic acid	A carbocyclic fatty acid composed of heptanoic acid having a (1S,2S)-2-octylcyclopentyl substituent at position 7.	Reaxys:5744307|Beilstein:5744307|KEGG:C02064|LIPID_MAPS_instance:LMFA03010000|PMID:6234649	hp.json	prostan-1-oic acid|7-[(1S,2S)-2-octylcyclopentyl]heptanoic acid|Prostanoic acid	http://purl.obolibrary.org/obo/CHEBI_8504		3_STAR
HP:0000541	biolink:PhenotypicFeature	Retinal detachment	Separation of the inner layers of the retina (neural retina) from the pigment epithelium.	MSH:D012163|SNOMEDCT_US:42059000|UMLS:C0035305	hp.json	Retinal detachment|Detached retina	http://purl.obolibrary.org/obo/HP_0000541		hposlim_core
HP:0000540	biolink:PhenotypicFeature	Hypermetropia	An abnormality of refraction characterized by the ability to see objects in the distance clearly, while objects nearby appear blurry.	UMLS:C0020490|MSH:D006956|SNOMEDCT_US:38101003	hp.json	Long-sightedness|Hyperopia|Farsightedness	http://purl.obolibrary.org/obo/HP_0000540		hposlim_core
HP:0000543	biolink:PhenotypicFeature	Optic disc pallor	A pale yellow discoloration of the optic disk (the area of the optic nerve head in the retina). The optic disc normally has a pinkish hue with a central yellowish depression.	UMLS:C0554970|SNOMEDCT_US:302200001	hp.json	Disc pallor|Pale optic disk|Pale optic discs|Pale optic disc	http://purl.obolibrary.org/obo/HP_0000543		hposlim_core
HP:0000542	biolink:PhenotypicFeature	Impaired ocular adduction	Reduced ability to move the eye in the direction of the nose.	UMLS:C1846463	hp.json		http://purl.obolibrary.org/obo/HP_0000542		
HP:0000545	biolink:PhenotypicFeature	Myopia	An abnormality of refraction characterized by the ability to see objects nearby clearly, while objects in the distance appear blurry.	UMLS:C0027092|MSH:D009216|SNOMEDCT_US:57190000	hp.json	Near sightedness|Nearsightedness|Close sighted|Near sighted	http://purl.obolibrary.org/obo/HP_0000545		hposlim_core
HP:0000544	biolink:PhenotypicFeature	External ophthalmoplegia	Paralysis of the external ocular muscles.	MSH:D017246|MSH:D009886|SNOMEDCT_US:19373007|UMLS:C0162292|UMLS:C0162674|SNOMEDCT_US:46252003	hp.json	Progressive paralysis or weakness of muscles of eye movement|Paralysis or weakness of muscles within or surrounding outer part of eye|Chronic progressive external ophthalmoplegia|Progressive paralysis or weakness of muscles of eye motility|Ophthalmoplegia externa|CPEO	http://purl.obolibrary.org/obo/HP_0000544		
HP:0012514	biolink:PhenotypicFeature	Lower limb pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the leg.	UMLS:C0023222|SNOMEDCT_US:10601006	hp.json	Leg pain|Lower limb pain	http://purl.obolibrary.org/obo/HP_0012514		
HP:0012515	biolink:PhenotypicFeature	Hip flexor weakness	Reduced ability to flex the femur, that is, to pull the knee upward.	UMLS:C3279725	hp.json		http://purl.obolibrary.org/obo/HP_0012515		
HP:0012516	biolink:PhenotypicFeature	Tetralogy of Fallot with pulmonary atresia	An extreme form of tetralogy of Fallot characterized by absence of flow from the right ventricle to the pulmonary arteries.	SNOMEDCT_US:253513005|UMLS:C0344882	hp.json		http://purl.obolibrary.org/obo/HP_0012516		
HP:0012517	biolink:PhenotypicFeature	Reduced catalase level	An abnormally decreased amount of catalase level.	UMLS:C4022869	hp.json		http://purl.obolibrary.org/obo/HP_0012517		
HP:0012518	biolink:PhenotypicFeature	Abnormal circle of Willis morphology	An anomaly of the circle of Willis, also known as the cerebral arterial circle.	UMLS:C4022868	hp.json	Abnormality of the cerebral arterial circle	http://purl.obolibrary.org/obo/HP_0012518		
HP:0012519	biolink:PhenotypicFeature	Hypoplastic posterior communicating artery	Underdeveloped posterior communicating artery.	UMLS:C4020720	hp.json	Hypoplastic posterior communicating arteries	http://purl.obolibrary.org/obo/HP_0012519		
CHEBI:30769	biolink:ChemicalSubstance	citric acid	A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.	PMID:17357118|BPDB:1359|PMID:19288211|PMID:18298573|PMID:22509852|PMID:22115968|HMDB:HMDB0000094|KEGG:C00158|Gmelin:4240|CAS:77-92-9|PMID:22264346|KEGG:D00037|Beilstein:782061|PMID:11762832|Drug_Central:666|PMID:17190852|DrugBank:DB04272|CAS:77-92-9|Reaxys:782061|CAS:77-92-9|MetaCyc:CIT|PMID:11782123|PMID:15311880|PMID:14537820|Wikipedia:Citric_Acid|PMID:22373571|PMID:16232627|PMID:11857437|KNApSAcK:C00007619|PDBeChem:CIT|PMID:22192423|PMID:17604395|PMID:18960216|PMID:15934243	hp.json	Citronensaeure|2-hydroxypropane-1,2,3-tricarboxylic acid|Citric acid|E330|2-Hydroxytricarballylic acid|CITRIC ACID|2-Hydroxy-1,2,3-propanetricarboxylic acid|H3cit|3-Carboxy-3-hydroxypentane-1,5-dioic acid	http://purl.obolibrary.org/obo/CHEBI_30769		3_STAR
CHEBI:88071	biolink:ChemicalSubstance	monosialodiglycosylceramide(1-)	An anionic ganglioside in which the oligosaccharide portion is composed of a disaccharide, to which one sialic acid residue is attached.		hp.json		http://purl.obolibrary.org/obo/CHEBI_88071		3_STAR
CHEBI:30768	biolink:ChemicalSubstance	propionic acid	A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.	CAS:79-09-4|Beilstein:506071|PDBeChem:PPI|PMID:1628870|Gmelin:1821|KEGG:D02310|PPDB:1341|KEGG:C00163|PMID:16763906|CAS:79-09-4|DrugBank:DB03766|LIPID_MAPS_instance:LMFA01010003|CAS:79-09-4|PMID:15868474	hp.json	ethanecarboxylic acid|acide propanoique|acide propionique|metacetonic acid|Propanoic acid|Propionic acid|pseudoacetic acid|propioic acid|methylacetic acid|ethylformic acid|propoic acid|PROPANOIC ACID|propanoic acid|Propionsaeure|carboxyethane|CH3-CH2-COOH|propionic acid|PA	http://purl.obolibrary.org/obo/CHEBI_30768		3_STAR
GO:1904319	biolink:BiologicalProcess	negative regulation of smooth muscle contraction involved in micturition	Any process that stops, prevents or reduces the frequency, rate or extent of smooth muscle contraction involved in micturition.		hp.json	downregulation of smooth muscle contraction involved in urination|down regulation of urinary bladder smooth muscle contraction involved in micturition|down-regulation of smooth muscle contraction involved in micturition|inhibition of smooth muscle contraction involved in urination|downregulation of urinary bladder smooth muscle contraction involved in micturition|down regulation of smooth muscle contraction involved in micturition|down-regulation of smooth muscle contraction involved in urination|negative regulation of smooth muscle contraction involved in urination|inhibition of smooth muscle contraction involved in micturition|downregulation of smooth muscle contraction involved in micturition|inhibition of urinary bladder smooth muscle contraction involved in micturition|down regulation of smooth muscle contraction involved in urination|down-regulation of urinary bladder smooth muscle contraction involved in micturition|negative regulation of urinary bladder smooth muscle contraction involved in micturition	http://purl.obolibrary.org/obo/GO_1904319		
GO:1904318	biolink:BiologicalProcess	regulation of smooth muscle contraction involved in micturition	Any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition.		hp.json	regulation of urinary bladder smooth muscle contraction involved in micturition|regulation of smooth muscle contraction involved in urination	http://purl.obolibrary.org/obo/GO_1904318		
CL:0000646	biolink:Cell	basal cell	Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament.	BTO:0000939|FMA:62516	hp.json		http://purl.obolibrary.org/obo/CL_0000646		
UBERON:0010543	biolink:AnatomicalEntity	acropodial skeleton	The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified].	FMA:231315|VSAO:0005028	hp.json	phalangeal skeleton|acropodial skeleton|acropodium|skeletal parts of acropodium|skeleton of digits|set of phalanges|skeletal parts of acropodial region|digits skeleton|acropodium skeleton|digital skeleton	http://purl.obolibrary.org/obo/UBERON_0010543		
CL:0000649	biolink:Cell	prickle cell	A cell with delicate radiating processes known as desmosomes that form intercellular bridges between other cells of this type. This cell type forms the stratum spinosum (prickle cell layer). A function of this cell is to generate keratin.	FMA:69059	hp.json	prickle cell of epidermis	http://purl.obolibrary.org/obo/CL_0000649		
UBERON:0010540	biolink:AnatomicalEntity	tarsus pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a tarsal bone.	EHDAA2:0001978	hp.json		http://purl.obolibrary.org/obo/UBERON_0010540		
UBERON:0010541	biolink:AnatomicalEntity	tarsus cartilage element	A cartilaginous condensation that has the potential to develop into a tarsal bone.	EHDAA2:0001977	hp.json		http://purl.obolibrary.org/obo/UBERON_0010541		
UBERON:0010535	biolink:AnatomicalEntity	primitive metanephric nephron	A primitive nephron that is part of a metanephros.	EHDAA2:0001516	hp.json	primitive metanephric nephron|primitive nephron|developing metanephric nephron	http://purl.obolibrary.org/obo/UBERON_0010535		
GO:1904320	biolink:BiologicalProcess	positive regulation of smooth muscle contraction involved in micturition	Any process that activates or increases the frequency, rate or extent of smooth muscle contraction involved in micturition.		hp.json	up-regulation of urinary bladder smooth muscle contraction involved in micturition|up regulation of urinary bladder smooth muscle contraction involved in micturition|upregulation of smooth muscle contraction involved in urination|activation of smooth muscle contraction involved in urination|positive regulation of urinary bladder smooth muscle contraction involved in micturition|up-regulation of smooth muscle contraction involved in micturition|up regulation of smooth muscle contraction involved in micturition|activation of smooth muscle contraction involved in micturition|upregulation of urinary bladder smooth muscle contraction involved in micturition|activation of urinary bladder smooth muscle contraction involved in micturition|up-regulation of smooth muscle contraction involved in urination|up regulation of smooth muscle contraction involved in urination|upregulation of smooth muscle contraction involved in micturition|positive regulation of smooth muscle contraction involved in urination	http://purl.obolibrary.org/obo/GO_1904320		
UBERON:0010536	biolink:AnatomicalEntity	nephron progenitor			hp.json		http://purl.obolibrary.org/obo/UBERON_0010536		
UBERON:0010533	biolink:AnatomicalEntity	metanephros cortex	The metanephric cortex is the outer region of the metanephros[GO].	VHOG:0000714	hp.json		http://purl.obolibrary.org/obo/UBERON_0010533		
UBERON:0009559	biolink:AnatomicalEntity	metacarpal/tarsal-phalangeal joint	A skeletal joint that connects a mesopodium bone and connects a proximal phalanx.		hp.json	metapodial-phalangeal joint|metapodium-phalanx joint|metacarpo-tarsophalangeal joint|fetlock	http://purl.obolibrary.org/obo/UBERON_0009559		
UBERON:0010534	biolink:AnatomicalEntity	primitive mesonephric nephron	Anatomical cluster which give rise to mature mesonephric nephrons. Zebrafish continously generate new mesonephric nephrons.	ZFA:0005584	hp.json	primitive mesonephric nephron|developing mesonephric nephron	http://purl.obolibrary.org/obo/UBERON_0010534		
UBERON:0010537	biolink:AnatomicalEntity	mesonephric nephron progenitor	Cluster of cells comprising a portion of tissue which gives rise to new mesonephric nephrons. The cluster contains self-renewing stem cells.	ZFA:0005587	hp.json		http://purl.obolibrary.org/obo/UBERON_0010537		
CL:0000642	biolink:Cell	folliculostellate cell	A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones.		hp.json		http://purl.obolibrary.org/obo/CL_0000642		
UBERON:0010538	biolink:AnatomicalEntity	paired limb/fin segment	An appendage segment that is part of a limb/fin.		hp.json	limb/fin segment	http://purl.obolibrary.org/obo/UBERON_0010538		homology_grouping
UBERON:0009550	biolink:AnatomicalEntity	endoderm of foregut-midgut junction	An endoderm that is part of a foregut-midgut junction.	EMAPA:18403|EHDAA2:0000572	hp.json		http://purl.obolibrary.org/obo/UBERON_0009550		emapa_ehdaa2
UBERON:0009551	biolink:AnatomicalEntity	distal segment of digit	A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium).		hp.json	tip of digit|digit tip|distal digit segment	http://purl.obolibrary.org/obo/UBERON_0009551		
UBERON:0009552	biolink:AnatomicalEntity	distal segment of manual digit	A segment of the manual digit containing the distal phalanx.	OpenCyc:Mx4rvVjpf5wpEbGdrcN5Y29ycA	hp.json	finger distal segment|tip of finger|finger tip|forelimb digit tip|finger digit tip|fingertip	http://purl.obolibrary.org/obo/UBERON_0009552		pheno_slim
UBERON:0009553	biolink:AnatomicalEntity	distal segment of pedal digit	A segment of the pedal digit containing the distal phalanx. Note this class represents a digit segment and thus includes tissues in addition to bone.		hp.json	toe distal segment|tip of toe|P3 segment of pedal digit|toe digit tip|hindlimb digit tip|distalmost part of toe	http://purl.obolibrary.org/obo/UBERON_0009553		
CHEBI:30776	biolink:ChemicalSubstance	hexanoic acid	A C6, straight-chain saturated fatty acid.	CAS:142-62-1|PMID:10685018|Beilstein:773837|KEGG:C01585|HMDB:HMDB0000535|PMID:24357269|Reaxys:773837|YMDB:YMDB01424|ECMDB:ECMDB21229|LIPID_MAPS_instance:LMFA01010006|MetaCyc:HEXANOATE|Gmelin:185066|KNApSAcK:C00001218|Wikipedia:Hexanoic_acid|CAS:142-62-1|PMID:24924750|CAS:142-62-1|PMID:1556177|PDBeChem:6NA	hp.json	1-pentanecarboxylic acid|Hexylic acid|6:0|capronic acid|CH3-[CH2]4-COOH|n-Caproic acid|C6:0|n-hexylic acid|Hexanoic acid|hexoic acid|pentiformic acid|pentylformic acid|n-hexanoic acid|1-hexanoic acid|n-hexoic acid|HEXANOIC ACID|caproic acid|butylacetic acid|Hexanoate|Pentanecarboxylic acid|hexanoic acid	http://purl.obolibrary.org/obo/CHEBI_30776		3_STAR
CL:0000656	biolink:Cell	primary spermatocyte	A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes.	CALOHA:TS-2194|BTO:0001115|FMA:72292	hp.json		http://purl.obolibrary.org/obo/CL_0000656		
CL:0000657	biolink:Cell	secondary spermatocyte	One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids.	CALOHA:TS-2195|BTO:0000709|FMA:72293|FBbt:00004941	hp.json		http://purl.obolibrary.org/obo/CL_0000657		
UBERON:0010531	biolink:AnatomicalEntity	metanephros induced blastemal cells		VHOG:0001241|EHDAA:7007|EHDAA:8105|EHDAA2:0001143|EMAPA:17953|MA:0002998|EMAPA:27621	hp.json	peripheral blastema|cap mesenchyme of metanephros of urinary system|induced blastemal cells|nephrogenic interstitium|nephrogenic interstitium of nephrogenic zone	http://purl.obolibrary.org/obo/UBERON_0010531		
UBERON:0010532	biolink:AnatomicalEntity	primitive nephron	An epithelial tube that is fated to become a nephron.		hp.json	presumptive nephron|primitive nephron|developing nephron|future nephron	http://purl.obolibrary.org/obo/UBERON_0010532		
GO:0062125	biolink:BiologicalProcess	regulation of mitochondrial gene expression	Any process that modulates the frequency, rate or extent of mitochondrial gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).		hp.json		http://purl.obolibrary.org/obo/GO_0062125		
UBERON:0009548	biolink:AnatomicalEntity	hepatic sinusoid of left of lobe of liver	A hepatic sinusoid that is part of a left lobe of liver.	EHDAA2:0001001|EMAPA:18309|VHOG:0000709	hp.json	left lobe hepatic sinusoids	http://purl.obolibrary.org/obo/UBERON_0009548		emapa_ehdaa2
UBERON:0010522	biolink:AnatomicalEntity	replacement element	Skeletal element that forms as a replacement or substitution of another element or tissue.	ZFA:0005624|XAO:0004016|VSAO:0000135	hp.json		http://purl.obolibrary.org/obo/UBERON_0010522		
CL:0000650	biolink:Cell	mesangial cell	A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries.	FMA:70972|CALOHA:TS-0617|BTO:0000853	hp.json	kidney mesangial cell	http://purl.obolibrary.org/obo/CL_0000650		
UBERON:0010523	biolink:AnatomicalEntity	microcirculatory vessel	A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses.	MESH:A07.231.432|TAO:0005251|MESH:D055806|ZFA:0005251	hp.json	microcirculatory vessels	http://purl.obolibrary.org/obo/UBERON_0010523		
UBERON:0009549	biolink:AnatomicalEntity	hepatic sinusoid of right of lobe of liver	A hepatic sinusoid that is part of a right lobe of liver.	VHOG:0000710|EMAPA:18316|EHDAA2:0001009	hp.json	right lobe hepatic sinusoids	http://purl.obolibrary.org/obo/UBERON_0009549		emapa_ehdaa2
UBERON:0010528	biolink:AnatomicalEntity	pneumatic cavity of bone		FMA:24028	hp.json	air space of bone	http://purl.obolibrary.org/obo/UBERON_0010528		
CL:0000652	biolink:Cell	pinealocyte	This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation.	BTO:0001068|FMA:83417	hp.json		http://purl.obolibrary.org/obo/CL_0000652		
UBERON:0010527	biolink:AnatomicalEntity	cavity of bone organ	An organ cavity that surrounded_by a bone.	FMA:24021	hp.json	bone organ cavity	http://purl.obolibrary.org/obo/UBERON_0010527		
CHEBI:30772	biolink:ChemicalSubstance	butyric acid	A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group.	CAS:107-92-6|PMID:22322557|PMID:22194341|PMID:19703412|PMID:19318247|PMID:11208715|PMID:15810631|HMDB:HMDB0000039|CAS:107-92-6|PMID:22038864|PMID:14962641|PMID:13678314|Wikipedia:Butyric_acid|CAS:107-92-6|PMID:11238216|PMID:12068484|PMID:15809727|MetaCyc:BUTYRIC_ACID|KNApSAcK:C00001180|PDBeChem:BUA|LIPID_MAPS_instance:LMFA01010004|PMID:22466881|PMID:11201044|DrugBank:DB03568|PMID:11305323|PMID:10956204|PMID:10736622|PMID:19366864|Beilstein:906770|PMID:21699495|Reaxys:906770|PMID:22339023|Gmelin:26242|PMID:1542095|KEGG:C00246|PMID:15938880	hp.json	n-butanoic acid|1-butanoic acid|acide butyrique|4:0|Butanoic acid|1-butyric acid|propylformic acid|propanecarboxylic acid|Butanoate|C4:0|Butyric acid|butoic acid|butanic acid|BUTANOIC ACID|butanoic acid|acide butanoique|Buttersaeure|n-butyric acid|butyric acid|1-propanecarboxylic acid|ethylacetic acid|CH3-[CH2]2-COOH	http://purl.obolibrary.org/obo/CHEBI_30772		3_STAR
CHEBI:30745	biolink:ChemicalSubstance	phenylacetic acid	A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.	PMID:24631718|YMDB:YMDB00891|PMID:15057459|PMID:17622769|PMID:12147706|Drug_Central:4624|KEGG:C07086|KNApSAcK:C00000750|PMID:7544181|ECMDB:ECMDB04128|Beilstein:1099647|CAS:103-82-2|HMDB:HMDB0000209|Reaxys:1099647|Gmelin:68976|CAS:103-82-2|PMID:15646820|PMID:12569987|PDBeChem:PAC|CAS:103-82-2|PMID:24587751|MetaCyc:PHENYLACETATE|PMID:15506622|Wikipedia:Phenylacetic_acid|PMID:7716788|PMID:2083978	hp.json	PA|2-Phenylethanoic acid|phenylacetic acid|benzeneacetic acid|Benzeneacetic acid|Phenylacetic acid|alpha-toluic acid|Omega-Phenylacetic acid|2-PHENYLACETIC ACID|omega-phenylacetic acid|Benzylformic acid	http://purl.obolibrary.org/obo/CHEBI_30745		3_STAR
UBERON:2005273	biolink:AnatomicalEntity	intestinal mucosal muscle	A thin layer of smooth muscle immediately beneath the base of the villi which permits the intestinal mucosa to dynamically move and fold.	ZFA:0005273	hp.json	intestinal lamina muscularis mucosae	http://purl.obolibrary.org/obo/UBERON_2005273		
CL:0000622	biolink:Cell	acinar cell	A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).	FMA:83625	hp.json	acinous cell|acinic cell	http://purl.obolibrary.org/obo/CL_0000622		
CL:0000623	biolink:Cell	natural killer cell	A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.	FMA:83601|BTO:0004716|FMA:63147|VHOG:0001697|CALOHA:TS-0664|BTO:0000914	hp.json	large granular lymphocyte|NK cell|null cell	http://purl.obolibrary.org/obo/CL_0000623		
CL:0000624	biolink:Cell	CD4-positive, alpha-beta T cell	A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor.		hp.json	CD4-positive, alpha-beta T-cell|CD4-positive, alpha-beta T lymphocyte|CD4-positive, alpha-beta T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000624		
CL:0000625	biolink:Cell	CD8-positive, alpha-beta T cell	A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor.		hp.json	CD8-positive, alpha-beta T-cell|CD8-positive, alpha-beta T lymphocyte|CD8-positive, alpha-beta T-lymphocyte	http://purl.obolibrary.org/obo/CL_0000625		
CL:0000626	biolink:Cell	olfactory granule cell	Granule cell that is part of the olfactory bulb.		hp.json		http://purl.obolibrary.org/obo/CL_0000626		
GO:1904343	biolink:BiologicalProcess	positive regulation of colon smooth muscle contraction	Any process that activates or increases the frequency, rate or extent of colon smooth muscle contraction.		hp.json	up-regulation of colon smooth muscle contraction|up regulation of colon smooth muscle contraction|activation of colon smooth muscle contraction|upregulation of colon smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904343		
GO:1904342	biolink:BiologicalProcess	negative regulation of colon smooth muscle contraction	Any process that stops, prevents or reduces the frequency, rate or extent of colon smooth muscle contraction.		hp.json	down regulation of colon smooth muscle contraction|downregulation of colon smooth muscle contraction|inhibition of colon smooth muscle contraction|down-regulation of colon smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904342		
UBERON:0009536	biolink:AnatomicalEntity	vascular element of left lung	A vascular plexus that is part of a left lung.	EHDAA2:0000963|EMAPA:17660	hp.json		http://purl.obolibrary.org/obo/UBERON_0009536		emapa_ehdaa2
GO:1904341	biolink:BiologicalProcess	regulation of colon smooth muscle contraction	Any process that modulates the frequency, rate or extent of colon smooth muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_1904341		
UBERON:0009537	biolink:AnatomicalEntity	vascular element of right lung	A vascular plexus that is part of a right lung.	EMAPA:17668|EHDAA2:0001757	hp.json		http://purl.obolibrary.org/obo/UBERON_0009537		emapa_ehdaa2
UBERON:0009538	biolink:AnatomicalEntity	mesenchyme of sublingual gland primordium	Mesenchyme that is part of a sublingual gland primordium.	EHDAA2:0001937|EMAPA:17754	hp.json		http://purl.obolibrary.org/obo/UBERON_0009538		emapa_ehdaa2
UBERON:0009539	biolink:AnatomicalEntity	mesenchyme of submandibular gland primordium	Mesenchyme that is part of a submandibular gland primordium.	EMAPA:17757|EHDAA2:0001941	hp.json	submaxillary gland primordium mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009539		emapa_ehdaa2
UBERON:2005260	biolink:AnatomicalEntity	fenestrated capillary	Capillary that has pores in the endothelial cells (60-80 nm in diameter) that are spanned by a diaphragm of radially oriented fibrils and allow small molecules and limited amounts of protein to diffuse.	NCIT:C32595|UMLS:C1179615|Wikipedia:Capillary#Types|ZFA:0005260|FMA:63196|TAO:0005260	hp.json	fenestrated capillary vessel|fenestrated blood vessel endothelium	http://purl.obolibrary.org/obo/UBERON_2005260		
GO:0015807	biolink:BiologicalProcess	L-amino acid transport	The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0015807		
GO:1904349	biolink:BiologicalProcess	positive regulation of small intestine smooth muscle contraction	Any process that activates or increases the frequency, rate or extent of small intestine smooth muscle contraction.		hp.json	up-regulation of small intestine smooth muscle contraction|up regulation of small intestine smooth muscle contraction|activation of small intestine smooth muscle contraction|upregulation of small intestine smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904349		
GO:1904348	biolink:BiologicalProcess	negative regulation of small intestine smooth muscle contraction	Any process that stops, prevents or reduces the frequency, rate or extent of small intestine smooth muscle contraction.		hp.json	down regulation of small intestine smooth muscle contraction|inhibition of small intestine smooth muscle contraction|downregulation of small intestine smooth muscle contraction|down-regulation of small intestine smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904348		
CL:0000636	biolink:Cell	Mueller cell	Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer.	BTO:0003064	hp.json	Muller glia|Müller cell	http://purl.obolibrary.org/obo/CL_0000636		
GO:1904347	biolink:BiologicalProcess	regulation of small intestine smooth muscle contraction	Any process that modulates the frequency, rate or extent of small intestine smooth muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_1904347		
CL:0000637	biolink:Cell	chromophil cell of anterior pituitary gland	A cell that stains readily in the anterior pituitary gland.	FMA:83089	hp.json		http://purl.obolibrary.org/obo/CL_0000637		
GO:1904346	biolink:BiologicalProcess	positive regulation of gastric mucosal blood circulation	Any process that activates or increases the frequency, rate or extent of gastric mucosal blood circulation.		hp.json	activation of stomach mucosal blood circulation|positive regulation of stomach mucosal blood circulation|up-regulation of gastric mucosal blood circulation|up regulation of gastric mucosal blood circulation|upregulation of stomach mucosal blood circulation|activation of gastric mucosal blood circulation|upregulation of gastric mucosal blood circulation|up-regulation of stomach mucosal blood circulation|up regulation of stomach mucosal blood circulation	http://purl.obolibrary.org/obo/GO_1904346		
CL:0000638	biolink:Cell	acidophil cell of pars distalis of adenohypophysis	An acidophilic chromophil cell that of the anterior pituitary gland.	FMA:83093	hp.json	acidophil cell of pars anterior of adenohypophysis|acidophil of pars anterior of adenohypophysis|acidophil of pars distalis of adenohypophysis|pituitary alpha cell	http://purl.obolibrary.org/obo/CL_0000638		
GO:1904345	biolink:BiologicalProcess	negative regulation of gastric mucosal blood circulation	Any process that stops, prevents or reduces the frequency, rate or extent of gastric mucosal blood circulation.		hp.json	inhibition of gastric mucosal blood circulation|downregulation of gastric mucosal blood circulation|negative regulation of stomach mucosal blood circulation|down-regulation of stomach mucosal blood circulation|down regulation of stomach mucosal blood circulation|down-regulation of gastric mucosal blood circulation|inhibition of stomach mucosal blood circulation|downregulation of stomach mucosal blood circulation|down regulation of gastric mucosal blood circulation	http://purl.obolibrary.org/obo/GO_1904345		
GO:1904344	biolink:BiologicalProcess	regulation of gastric mucosal blood circulation	Any process that modulates the frequency, rate or extent of gastric mucosal blood circulation.		hp.json	regulation of stomach mucosal blood circulation	http://purl.obolibrary.org/obo/GO_1904344		
GO:0086103	biolink:BiologicalProcess	G protein-coupled receptor signaling pathway involved in heart process	An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart.		hp.json	GPCR signaling pathway involved in cardiac process|G-protein coupled receptor signaling pathway involved in heart process|G-protein coupled receptor signalling pathway involved in heart process|GPCR signaling pathway involved in heart process	http://purl.obolibrary.org/obo/GO_0086103		
GO:0015800	biolink:BiologicalProcess	acidic amino acid transport	The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0015800		
UBERON:0009526	biolink:AnatomicalEntity	maxillary process mesenchyme	Mesenchyme that is part of a maxillary prominence.	FMA:312691|EMAPA:17361|EHDAA2:0001071	hp.json	mesenchyme of maxillary process|mesenchyme of maxillary prominence	http://purl.obolibrary.org/obo/UBERON_0009526		emapa_ehdaa2
CL:0000630	biolink:Cell	supporting cell	A cell whose primary function is to support other cell types.	BTO:0002315	hp.json	supportive cell	http://purl.obolibrary.org/obo/CL_0000630		
CHEBI:30751	biolink:ChemicalSubstance	formic acid	The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.	PMID:22280475|PMID:16222862|PMID:22622393|Reaxys:1209246|PMID:16230297|PMID:7361809|Beilstein:1209246|KEGG:C00058|Patent:CN101481304|PMID:16465784|LIPID_MAPS_instance:LMFA01010040|CAS:64-18-6|Gmelin:1008|PMID:22080171|PMID:22540994|PMID:15811469|MetaCyc:FORMATE|PMID:22304812|Wikipedia:Formic_acid|KNApSAcK:C00001182|DrugBank:DB01942|BPDB:1749|PMID:22483350|PMID:22499553|CAS:64-18-6|PMID:3946945|PMID:12591956|CAS:64-18-6|PMID:18034701|PMID:16120414|PMID:22447125|PDBeChem:FMT|PMID:22385261|PMID:14637377|PMID:16185830|PMID:22606986|HMDB:HMDB0000142|PMID:16445901|PMID:18397576	hp.json	hydrogen carboxylic acid|H-COOH|Formic acid|HCO2H|Acide formique|aminic acid|FORMIC ACID|HCOOH|Methanoic acid|Ameisensaeure|bilorin|formylic acid|formic acid|methoic acid	http://purl.obolibrary.org/obo/CHEBI_30751		3_STAR
NCBITaxon:88770	biolink:OrganismalEntity	Panarthropoda		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_88770		
CHEBI:17792	biolink:ChemicalSubstance	organohalogen compound	A compound containing at least one carbon-halogen bond (where X is a halogen atom).	MetaCyc:Organohalogen-Compounds|KEGG:C01322	hp.json	organohalogen compounds|RX|organic halides|RX|organic halide	http://purl.obolibrary.org/obo/CHEBI_17792		3_STAR
UBERON:0009521	biolink:AnatomicalEntity	anal membrane endodermal component	An endoderm that is part of a anal region.	EHDAA2:0004020|EMAPA:17177	hp.json		http://purl.obolibrary.org/obo/UBERON_0009521		emapa_ehdaa2
GO:0003824	biolink:MolecularActivity	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.	Wikipedia:Enzyme	hp.json	enzyme activity	http://purl.obolibrary.org/obo/GO_0003824		goslim_pir|goslim_plant|goslim_flybase_ribbon|goslim_metagenomics|goslim_chembl|goslim_agr|goslim_generic
UBERON:0009522	biolink:AnatomicalEntity	lateral lingual swelling epithelium	An epithelium that is part of a lateral lingual swelling.	FMA:313717|EHDAA2:0000913|EMAPA:17190	hp.json		http://purl.obolibrary.org/obo/UBERON_0009522		emapa_ehdaa2
CHEBI:17790	biolink:ChemicalSubstance	methanol	The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	UM-BBD_compID:c0132|PMID:14760634|PMID:14012711|PMID:11430978|MetaCyc:METOH|PMID:19064074|PMID:19850112|Reaxys:1098229|Beilstein:1098229|PDBeChem:MOH|PMID:16705261|PMID:15906011|CAS:67-56-1|Gmelin:449|PMID:14678513|KEGG:C00132|HMDB:HMDB0001875|PMID:11684179|CAS:67-56-1|PMID:11489599|CAS:67-56-1|Wikipedia:Methanol|PMID:11141607|PMID:15172721|PMID:17451998|PMID:11680737|PMID:20314698|KEGG:D02309|PMID:17733096	hp.json	wood alcohol|Methylalkohol|METHANOL|wood spirit|methanol|spirit of wood|methanol|CH3OH|carbinol|Methyl alcohol|wood naphtha|Methanol|MeOH	http://purl.obolibrary.org/obo/CHEBI_17790		3_STAR
UBERON:0009523	biolink:AnatomicalEntity	mesenchyme of handplate	Mesenchyme that is part of a handplate.	EMAPA:17457|EMAPA:17248|EHDAA2:0000731	hp.json	handplate mesenchyme|hand plate mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009523		emapa_ehdaa2
UBERON:0010582	biolink:AnatomicalEntity	pedal digit 3 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a pedal digit 3 mesenchyme.	EHDAA2:0002051|EMAPA:17730	hp.json	foot digit 3 phalanx pre-cartilage condensation|pedal digit III phalanx pre-cartilage condensation|hind limb digit 3 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010582		
UBERON:0010583	biolink:AnatomicalEntity	pedal digit 4 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a pedal digit 4 mesenchyme.	EHDAA2:0002056|EMAPA:17732	hp.json	hind limb digit 4 phalanx pre-cartilage condensation|foot digit 4 phalanx pre-cartilage condensation|pedal digit IV phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010583		
UBERON:0010580	biolink:AnatomicalEntity	pedal digit 1 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a pedal digit 1 mesenchyme.	EMAPA:17726|EHDAA2:0002041	hp.json	foot digit 1 phalanx pre-cartilage condensation|pedal digit I phalanx pre-cartilage condensation|hind limb digit 1 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010580		
UBERON:0010581	biolink:AnatomicalEntity	pedal digit 2 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a pedal digit 2 mesenchyme.	EMAPA:17728|EHDAA2:0002046	hp.json	pedal digit II phalanx pre-cartilage condensation|foot digit 2 phalanx pre-cartilage condensation|hind limb digit 2 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010581		
UBERON:0010586	biolink:AnatomicalEntity	manual digit phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a manual digit mesenchyme.	VHOG:0000954|EMAPA:32639	hp.json	forelimb phalanx pre-cartilage condensation|hand digit phalanx pre-cartilage condensation|fore limb digit phalanx pre-cartilage condensation|hand phalanx pre-cartilage condensation|manus phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010586		
CL:0000604	biolink:Cell	retinal rod cell	One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.	CALOHA:TS-0870|FMA:67747|BTO:0001024	hp.json		http://purl.obolibrary.org/obo/CL_0000604		
UBERON:0010584	biolink:AnatomicalEntity	pedal digit 5 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a pedal digit 5 mesenchyme.	EMAPA:17734|EHDAA2:0002061	hp.json	hind limb digit 5 phalanx pre-cartilage condensation|pedal digit V phalanx pre-cartilage condensation|foot digit 5 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010584		
UBERON:0010585	biolink:AnatomicalEntity	pedal digit phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a pedal digit mesenchyme.	VHOG:0000952|EMAPA:32950	hp.json	foot digit phalanx pre-cartilage condensation|pes phalanx pre-cartilage condensation|foot phalanx pre-cartilage condensation|hind limb digit phalanx pre-cartilage condensation|hindlimb phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010585		
UBERON:0010579	biolink:AnatomicalEntity	manual digit 5 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a manual digit 5 mesenchyme.	EHDAA2:0000540|EMAPA:17723	hp.json	fore limb digit 5 phalanx pre-cartilage condensation|manual digit V phalanx pre-cartilage condensation|hand digit 5 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010579		
GO:1904364	biolink:NamedThing	positive regulation of calcitonin secretion			hp.json		http://purl.obolibrary.org/obo/GO_1904364		
UBERON:0010577	biolink:AnatomicalEntity	manual digit 3 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a manual digit 3 mesenchyme.	EMAPA:17719|EHDAA2:0000528	hp.json	manual digit III phalanx pre-cartilage condensation|hand digit 3 phalanx pre-cartilage condensation|fore limb digit 3 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010577		
GO:1904363	biolink:NamedThing	negative regulation of calcitonin secretion			hp.json		http://purl.obolibrary.org/obo/GO_1904363		
UBERON:0010578	biolink:AnatomicalEntity	manual digit 4 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a manual digit 4 mesenchyme.	EMAPA:17721|EHDAA2:0000534	hp.json	manual digit IV phalanx pre-cartilage condensation|hand digit 4 phalanx pre-cartilage condensation|fore limb digit 4 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010578		
GO:1904362	biolink:NamedThing	regulation of calcitonin secretion			hp.json		http://purl.obolibrary.org/obo/GO_1904362		
UBERON:0009580	biolink:AnatomicalEntity	diencephalon mantle layer		VHOG:0000912|EMAPA:16906|EHDAA2:0000397	hp.json	mantle layer lateral wall diencephalon|diencephalon lateral wall mantle layer	http://purl.obolibrary.org/obo/UBERON_0009580		
UBERON:0009581	biolink:AnatomicalEntity	midbrain mantle layer		VHOG:0000910|EMAPA:16977|EHDAA2:0001172	hp.json	mantle layer lateral wall mesencephalon|mantle layer lateral wall midbrain|midbrain lateral wall mantle layer	http://purl.obolibrary.org/obo/UBERON_0009581		
UBERON:0010571	biolink:AnatomicalEntity	manual digit 2 metacarpus cartilage element	A manual digit metacarpus cartilage element that is part of a manual digit 2 mesenchyme.	EMAPA:18070|EHDAA2:0000520	hp.json	metacarpus 2 cartilage element|manual digit II metacarpus cartilage element|hand digit 2 metacarpus cartilage element|finger 2 metacarpus cartilage element|fore limb digit 2 metacarpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0010571		
UBERON:0010572	biolink:AnatomicalEntity	manual digit 3 metacarpus cartilage element	A manual digit metacarpus cartilage element that is part of a manual digit 3 mesenchyme.	EMAPA:18075|EHDAA2:0000526	hp.json	manual digit III metacarpus cartilage element|hand digit 3 metacarpus cartilage element|fore limb digit 3 metacarpus cartilage element|finger 3 metacarpus cartilage element|metacarpus 3 cartilage element	http://purl.obolibrary.org/obo/UBERON_0010572		
UBERON:0010570	biolink:AnatomicalEntity	manual digit 1 metacarpus cartilage element	A manual digit metacarpus cartilage element that is part of a manual digit 1 mesenchyme.	EHDAA2:0000514|EMAPA:18065	hp.json	manual digit I metacarpus cartilage element|metacarpus 1 cartilage element|hand digit 1 metacarpus cartilage element|fore limb digit 1 metacarpus cartilage element|finger 1 metacarpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0010570		
UBERON:0010575	biolink:AnatomicalEntity	manual digit 1 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a manual digit 1 mesenchyme.	EMAPA:17715|EHDAA2:0000516	hp.json	hand digit 1 phalanx pre-cartilage condensation|manual digit I phalanx pre-cartilage condensation|fore limb digit 1 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010575		
UBERON:0010576	biolink:AnatomicalEntity	manual digit 2 phalanx pre-cartilage condensation	A pre-cartilage condensation that is part of a manual digit 2 mesenchyme.	EMAPA:17717|EHDAA2:0000522	hp.json	manual digit II phalanx pre-cartilage condensation|hand digit 2 phalanx pre-cartilage condensation|fore limb digit 2 phalanx pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010576		
UBERON:0010573	biolink:AnatomicalEntity	manual digit 4 metacarpus cartilage element	A manual digit metacarpus cartilage element that is part of a manual digit 4 mesenchyme.	EMAPA:18080|EHDAA2:0000532	hp.json	manual digit IV metacarpus cartilage element|finger 4 metacarpus cartilage condensation|hand digit 4 metacarpus cartilage element|fore limb digit 4 metacarpus cartilage element|metacarpus 4 cartilage element	http://purl.obolibrary.org/obo/UBERON_0010573		
CL:0000617	biolink:Cell	GABAergic neuron	A neuron that uses GABA as a vesicular neurotransmitter	FMA:84788|WBbt:0005190	hp.json	GABA-ergic neuron	http://purl.obolibrary.org/obo/CL_0000617		
UBERON:0010574	biolink:AnatomicalEntity	manual digit 5 metacarpus cartilage element	A manual digit metacarpus cartilage element that is part of a manual digit 5 mesenchyme.	EMAPA:18085|EHDAA2:0000538	hp.json	hand digit 5 metacarpus cartilage element|finger 5 metacarpus cartilage condensation|fore limb digit 5 metacarpus cartilage element|metacarpus 5 cartilage element|manual digit V metacarpus cartilage element	http://purl.obolibrary.org/obo/UBERON_0010574		
GO:1904376	biolink:BiologicalProcess	negative regulation of protein localization to cell periphery	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell periphery.		hp.json	down-regulation of protein localization to cell periphery|downregulation of protein localization to cell periphery|down regulation of protein localization to cell periphery|inhibition of protein localization to cell periphery	http://purl.obolibrary.org/obo/GO_1904376		
UBERON:0010568	biolink:AnatomicalEntity	manual digit 4 metacarpus pre-cartilage condensation	A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 4 mesenchyme.	EHDAA2:0000533|EMAPA:17720	hp.json	metacarpal 4 pre-cartilage condensation|hand digit 4 metacarpus pre-cartilage condensation|fore limb digit 4 metacarpus pre-cartilage condensation|manual digit IV metacarpus pre-cartilage condensation|finger 4 metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010568		
UBERON:0010569	biolink:AnatomicalEntity	manual digit 5 metacarpus pre-cartilage condensation	A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 5 mesenchyme.	EHDAA2:0000539|EMAPA:17722	hp.json	hand digit 5 metacarpus pre-cartilage condensation|metacarpal 5 pre-cartilage condensation|finger 5 metacarpus pre-cartilage condensation|fore limb digit 5 metacarpus pre-cartilage condensation|manual digit V metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010569		
GO:1904375	biolink:BiologicalProcess	regulation of protein localization to cell periphery	Any process that modulates the frequency, rate or extent of protein localization to cell periphery.		hp.json		http://purl.obolibrary.org/obo/GO_1904375		
UBERON:0010566	biolink:AnatomicalEntity	manual digit 2 metacarpus pre-cartilage condensation	A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 2 mesenchyme.	EHDAA2:0000521|EMAPA:17716	hp.json	metacarpal 2 pre-cartilage condensation|hand digit 2 metacarpus pre-cartilage condensation|manual digit II metacarpus pre-cartilage condensation|fore limb digit 2 metacarpus pre-cartilage condensation|finger 2 metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010566		
UBERON:0010567	biolink:AnatomicalEntity	manual digit 3 metacarpus pre-cartilage condensation	A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 3 mesenchyme.	EMAPA:17718|EHDAA2:0000527	hp.json	metacarpal 3 pre-cartilage condensation|finger 3 metacarpus pre-cartilage condensation|hand digit 3 metacarpus pre-cartilage condensation|manual digit III metacarpus pre-cartilage condensation|fore limb digit 3 metacarpus pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010567		
UBERON:0009583	biolink:AnatomicalEntity	spinal cord mantle layer		VHOG:0000911|EMAPA:17580	hp.json	mantle layer lateral wall spinal cord|spinal cord lateral wall mantle layer	http://purl.obolibrary.org/obo/UBERON_0009583		
UBERON:0009584	biolink:AnatomicalEntity	1st arch mandibular mesenchyme	Mesenchyme that is part of a 1st arch mandibular component.	EMAPA:16385|EHDAA2:0000034	hp.json	mesenchymal region of mandibular component of first pharyngeal arch|mandibular component mesenchyme|mandibular mesenchyme|mesenchymal region of mandibular component of first pharyngeal arch|mesenchyme of mandibular component	http://purl.obolibrary.org/obo/UBERON_0009584		
UBERON:0009570	biolink:AnatomicalEntity	spinal cord sulcus limitans	A sulcus limitans of neural tube that is part of a future spinal cord.	EMAPA:17584|VHOG:0001548|EHDAA2:0001265	hp.json	spinal cord lateral wall sulcus limitans	http://purl.obolibrary.org/obo/UBERON_0009570		
UBERON:0010560	biolink:AnatomicalEntity	pedal digit 4 metatarsal cartilage element	A pedal digit metatarsal cartilage element that is part of a pedal digit 4 mesenchyme.	EMAPA:18121	hp.json	toe 4 metatarsal cartilage element|foot digit 4 metatarsal cartilage element|hind limb digit 4 metatarsal cartilage condensation|pedal digit IV metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0010560		
UBERON:0010561	biolink:AnatomicalEntity	pedal digit 5 metatarsal cartilage element	A pedal digit metatarsal cartilage element that is part of a pedal digit 5 mesenchyme.	EMAPA:18126	hp.json	hind limb digit 5 metatarsal cartilage element|toe 5 metatarsal cartilage element|pedal digit V metatarsal cartilage element|foot digit 5 metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0010561		
UBERON:0010564	biolink:AnatomicalEntity	manual digit 1 mesenchyme	Mesenchyme that is part of a developing manual digit 1.	EHDAA2:0000513|EMAPA:17431	hp.json	manual digit I mesenchyme|hand digit 1 mesenchyme|fore limb digit 1 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010564		
UBERON:0010565	biolink:AnatomicalEntity	manual digit 1 metacarpus pre-cartilage condensation	A manual digit metacarpus pre-cartilage condensation that is part of a manual digit 1 mesenchyme.	EMAPA:17714|EHDAA2:0000515	hp.json	finger 1 metacarpus pre-cartilage condensation|hand digit 1 metacarpus pre-cartilage condensation|manual digit I metacarpus pre-cartilage condensation|fore limb digit 1 metacarpus pre-cartilage condensation|metacarpal 1 pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010565		
UBERON:0010562	biolink:AnatomicalEntity	pedal digit 1 mesenchyme	Mesenchyme that is part of a developing pedal digit 1.	EMAPA:17462|EHDAA2:0002039	hp.json	foot digit 1 mesenchyme|pedal digit I mesenchyme|hind limb digit 1 mesenchyme	http://purl.obolibrary.org/obo/UBERON_0010562		
GO:1904377	biolink:BiologicalProcess	positive regulation of protein localization to cell periphery	Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery.		hp.json	upregulation of protein localization to cell periphery|up regulation of protein localization to cell periphery|activation of protein localization to cell periphery|up-regulation of protein localization to cell periphery	http://purl.obolibrary.org/obo/GO_1904377		
UBERON:0010557	biolink:AnatomicalEntity	pedal digit 1 metatarsal cartilage element	A pedal digit metatarsal cartilage condensation that is part of a pedal digit 1 mesenchyme.	EMAPA:18106	hp.json	toe 1 metatarsal cartilage condensation|hind limb digit 1 metatarsal cartilage condensation|foot digit 1 metatarsal cartilage element|pedal digit I metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0010557		
UBERON:0010558	biolink:AnatomicalEntity	pedal digit 2 metatarsal cartilage element	A pedal digit metatarsal cartilage element that is part of a pedal digit 2 mesenchyme.	EMAPA:18111	hp.json	hind limb digit 2 metatarsal cartilage condensation|pedal digit II metatarsal cartilage element|toe 2 metatarsal cartilage element|foot digit 2 metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0010558		
UBERON:0010559	biolink:AnatomicalEntity	pedal digit 3 metatarsal cartilage element	A pedal digit metatarsal cartilage element that is part of a pedal digit 3 mesenchyme.	EMAPA:18116	hp.json	hind limb digit 3 metatarsal cartilage condensation|toe 3 metatarsal cartilage element|foot digit 3 metatarsal cartilage element|pedal digit III metatarsal cartilage element	http://purl.obolibrary.org/obo/UBERON_0010559		
UBERON:0009572	biolink:AnatomicalEntity	lumen of central canal of spinal cord	A cerebrospinal fluid-filled space that runs longitudinally through the length of the entire spinal cord. The central canal is contiguous with the ventricular system of the brain. The central canal represents the adult remainder of the neural tube.	EMAPA:25042|FMA:242845	hp.json	cavity of central canal of spinal cord|neural lumen|spinal cord lumen|central canal lumen	http://purl.obolibrary.org/obo/UBERON_0009572		
CHEBI:17761	biolink:ChemicalSubstance	ceramide	Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms; the presence of a hydroxyl group on carbon 2 is fairly common. Ceramides are generally precursors of more complex sphingolipids. In the illustrated generalised structure, R(1) = OH, OX (where X = acyl, glycosyl, phosphate, phosphonate, etc.), or H.	KEGG:C00195|LIPID_MAPS_class:LMSP02|Wikipedia:Ceramide|PMID:7542630	hp.json	ceramides|N-acylated sphingoid|a ceramide|Ceramide|Cer	http://purl.obolibrary.org/obo/CHEBI_17761		3_STAR
UBERON:0009576	biolink:AnatomicalEntity	medulla oblongata sulcus limitans	A sulcus limitans of neural tube that is part of a future medulla oblongata.	EMAPA:17561|EHDAA2:0001100	hp.json		http://purl.obolibrary.org/obo/UBERON_0009576		
UBERON:0009577	biolink:AnatomicalEntity	metencephalon sulcus limitans	A sulcus limitans of neural tube that is part of a future metencephalon.	EMAPA:17567|EHDAA2:0001161	hp.json		http://purl.obolibrary.org/obo/UBERON_0009577		
UBERON:0009578	biolink:AnatomicalEntity	myelencephalon sulcus limitans	A sulcus limitans of neural tube that is part of a future myelencephalon.	EHDAA2:0001945	hp.json		http://purl.obolibrary.org/obo/UBERON_0009578		
UBERON:0010550	biolink:AnatomicalEntity	pedal digit 4 metatarsal pre-cartilage condensation	A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 4 mesenchyme.	EHDAA2:0002055|EMAPA:17731	hp.json	foot digit 4 metatarsal pre-cartilage condensation|hind limb digit 4 metatarsal pre-cartilage condensation|toe 4 metatarsal pre-cartilage condensation|pedal digit IV metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010550		
UBERON:0010551	biolink:AnatomicalEntity	pedal digit 5 metatarsal pre-cartilage condensation	A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 5 mesenchyme.	EMAPA:17733|EHDAA2:0002060	hp.json	foot digit 5 metatarsal pre-cartilage condensation|hind limb digit 5 metatarsal pre-cartilage condensation|pedal digit V metatarsal pre-cartilage condensation|toe 5 metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010551		
GO:1904398	biolink:BiologicalProcess	positive regulation of neuromuscular junction development	Any process that activates or increases the frequency, rate or extent of neuromuscular junction development.		hp.json	activation of neuromuscular junction organization|positive regulation of neuromuscular junction organization|activation of NMJ stability|upregulation of neuromuscular junction organization|up regulation of neuromuscular junction development|activation of neuromuscular junction stability|upregulation of neuromuscular junction stability|up-regulation of NMJ stability|up-regulation of neuromuscular junction development|activation of neuromuscular junction development|up regulation of NMJ stability|positive regulation of neuromuscular junction stability|up-regulation of neuromuscular junction organization|up regulation of neuromuscular junction stability|positive regulation of NMJ stability|up regulation of neuromuscular junction organization|upregulation of neuromuscular junction development|up-regulation of neuromuscular junction stability|upregulation of NMJ stability	http://purl.obolibrary.org/obo/GO_1904398		
UBERON:0010546	biolink:AnatomicalEntity	metapodial skeleton	Subdivision of skeleton that corresponds to metapodium region, between acropodial skeleton and mesopdoial skeleton.	VSAO:0005025	hp.json	skeletal parts of metapodium|metapodium|metapodial skeleton|metacarpal/metatarsal skeleton|skeleton of metapodium|metapodium skeleton	http://purl.obolibrary.org/obo/UBERON_0010546		
UBERON:0009568	biolink:AnatomicalEntity	trunk region of vertebral column	Subdivision of vertebral column that corresponds to the trunk of the body, containing the trunk/presacral vertebrae. In organisms that have a thoracic and lumbar distinction, this corresponds to the sum of both of these regions.	NCIT:C92597|AAO:0000612|FMA:72066	hp.json	trunk skeleton|trunk vertebral column|thoracolumbar vertebral column|trunk spine|trunk region|thoracolumbar column|thoracolumbar region|thoracolumbar region of vertebral column|thoracolumbar vertebrae set|trunk vertebrae series|presacral region	http://purl.obolibrary.org/obo/UBERON_0009568		pheno_slim
GO:1904397	biolink:BiologicalProcess	negative regulation of neuromuscular junction development	Any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development.		hp.json	down regulation of NMJ stability|down regulation of neuromuscular junction stability|negative regulation of neuromuscular junction organization|down-regulation of neuromuscular junction organization|down-regulation of neuromuscular junction stability|negative regulation of neuromuscular junction stability|downregulation of NMJ stability|downregulation of neuromuscular junction development|down regulation of neuromuscular junction organization|inhibition of neuromuscular junction stability|inhibition of neuromuscular junction organization|inhibition of NMJ stability|down regulation of neuromuscular junction development|downregulation of neuromuscular junction organization|inhibition of neuromuscular junction development|downregulation of neuromuscular junction stability|down-regulation of neuromuscular junction development|down-regulation of NMJ stability|negative regulation of NMJ stability	http://purl.obolibrary.org/obo/GO_1904397		
UBERON:0009569	biolink:AnatomicalEntity	subdivision of trunk		FMA:25054|SCTID:22943007	hp.json	region of trunk|trunk subdivision	http://purl.obolibrary.org/obo/UBERON_0009569		non_informative
UBERON:0010547	biolink:AnatomicalEntity	pedal digit 1 metatarsal pre-cartilage condensation	A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 1 mesenchyme.	EMAPA:17725|EHDAA2:0002040	hp.json	pedal digit I metatarsal pre-cartilage condensation|toe 1 metatarsal pre-cartilage condensation|hind limb digit 1 metatarsal pre-cartilage condensation|foot digit 1 metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010547		
GO:1904396	biolink:BiologicalProcess	regulation of neuromuscular junction development	Any process that modulates the frequency, rate or extent of neuromuscular junction development.		hp.json	regulation of NMJ stability|regulation of neuromuscular junction organization|regulation of neuromuscular junction stability	http://purl.obolibrary.org/obo/GO_1904396		
UBERON:0010544	biolink:AnatomicalEntity	metacarpus skeleton	The metacarpus is the intermediate part of the manus skeleton that is located between the phalanges (bones of the fingers) distally and the carpus which forms the connection to the forearm. The metacarpus consists of metacarpal bones. The metacarpals form a transverse arch to which the rigid row of distal carpal bones are fixed. The peripheral metacarpals (those of the thumb and little finger) form the sides of the cup of the palmar gutter and as they are brought together they deepen this concavity. The index metacarpal is the most firmly fixed, while the thumb metacarpal articulates with the trapezium and acts independently from the others. The middle metacarpals are tightly united to the carpus by intrinsic interlocking bone elements at their bases. The ring metacarpal forms a transitional element of the semi-independent last metacarpal. [WP,unvetted].	FMA:71336|XAO:0003208|EMAPA:36158|AAO:0000946|VSAO:0005026|MESH:D050279	hp.json	fore metapodial skeleton|metacarpals set|set of metacarpal bones|ossa metacarpi [I-V]|set of metacarpals [I-V]|metacarpalia|anterior metapodium|skeleton of metacarpus|ossa metacarpalia [I-V]|metacarpals [I-V]|set of metacarpals|metacarpal skeleton|anterior metapodial skeleton|fore metapodium|metacarpal bones	http://purl.obolibrary.org/obo/UBERON_0010544		
UBERON:0010545	biolink:AnatomicalEntity	metatarsus skeleton	Limb segment that consists of the long bones of the pes. The metatarsals are analogous to the metacarpal bones of the manus.	XAO:0003212|OpenCyc:Mx4rva_rBJwpEbGdrcN5Y29ycA|AAO:0000221|FMA:71340|MESH:D008684|VSAO:0005027	hp.json	ossa metatarsi[I-V]|metatarsal skeleton|posterior metapodium|set of metatarsals [I-V]|ossa metatarsalia [I-V]|metatarsal bones set|ossa metatarsalia|posterior metapodial skeleton|skeleton of metatarsus|metatarsals [I-V]|set of metatarsal bones|metatarsalia	http://purl.obolibrary.org/obo/UBERON_0010545		
CHEBI:17759	biolink:ChemicalSubstance	cholesta-5,7-dien-3beta-ol		Beilstein:2224615|LIPID_MAPS_instance:LMST01010069|KEGG:C01164|KNApSAcK:C00023747|CAS:434-16-2|CAS:434-16-2|Gmelin:893079|CAS:434-16-2	hp.json	7-Dehydrocholesterol|cholesta-5,7-dien-3beta-ol|Cholesta-5,7-dien-3beta-ol|7-dehydrocholesterol|5,7-cholestadien-3-beta-ol|5,7-cholestadien-3beta-ol|Provitamin D3|(3beta)-cholesta-5,7-dien-3-ol	http://purl.obolibrary.org/obo/CHEBI_17759		3_STAR
CHEBI:17754	biolink:ChemicalSubstance	glycerol	A triol with a structure of propane substituted at positions 1, 2 and 3 by hydroxy groups.	KNApSAcK:C00001163|PDBeChem:GOL|PMID:558160|PMID:16664750|Reaxys:635685|PMID:16901854|PMID:19548674|PMID:17439666|PMID:15026783|PMID:16349488|CAS:56-81-5|PMID:24835191|Wikipedia:Glycerol|PMID:23562176|PMID:16319039|PMID:12689633|MetaCyc:GLYCEROL|PMID:15786693|PMID:11958517|PMID:11994365|PMID:11302662|PMID:17979222|PMID:25108762|CAS:56-81-5|PMID:14563847|Gmelin:26279|Drug_Central:1316|CAS:56-81-5|PMID:16475911|PMID:19795216|PMID:16244855|PMID:16258193|FooDB:FDB000756|PMID:7031247|PMID:19231894|PMID:24643482|PMID:6299616|PMID:16651733|UM-BBD_compID:c0066|PMID:15342117|PMID:15983192|LINCS:LSM-37180|HMDB:HMDB0000131|PMID:22705534|PMID:7392035|PMID:12672239|PMID:19460032|PDB:2AJS|PMID:12713573|PPDB:1317|KEGG:C00116|YMDB:YMDB00283|PMID:17336832|KEGG:D00028|PMID:14559393|PMID:23747440|PDB:2D03|PMID:12687625|DrugBank:DB04077|PMID:19956799|Beilstein:635685|Chemspider:733|PMID:19184438|ECMDB:ECMDB00131	hp.json	1,2,3-Propanetriol|glycyl alcohol|Glyceritol|Glyzerin|Glycerin|Propanetriol|1,2,3-Trihydroxypropane|Gro|Glycerol|glycerine|Trihydroxypropane|glycerol|propane-1,2,3-triol|GLYCEROL|glycerol|glycerol|Oelsuess|glycerolum	http://purl.obolibrary.org/obo/CHEBI_17754		3_STAR
UBERON:0010548	biolink:AnatomicalEntity	pedal digit 2 metatarsal pre-cartilage condensation	A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 2 mesenchyme.	EHDAA2:0002045|EMAPA:17727	hp.json	hind limb digit 2 metatarsal pre-cartilage condensation|foot digit 2 metatarsal pre-cartilage condensation|toe 2 metatarsal pre-cartilage condensation|pedal digit II metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010548		
CHEBI:17755	biolink:ChemicalSubstance	cystathionine	A modified amino acid generated by enzymic means from homocysteine and serine.	PMID:12907234|Reaxys:2416815|PMID:22212096|PMID:15033753|PMID:22264337|CAS:535-34-2|KEGG:C00542|CAS:535-34-2	hp.json	S-(2-amino-2-carboxyethyl)homocysteine|DL-Cystathionine|Cystathionine|2-amino-4-[(2-amino-2-carboxyethyl)sulfanyl]butanoic acid|cystathione	http://purl.obolibrary.org/obo/CHEBI_17755		3_STAR
UBERON:0010549	biolink:AnatomicalEntity	pedal digit 3 metatarsal pre-cartilage condensation	A pedal digit metatarsal pre-cartilage condensation that is part of a pedal digit 3 mesenchyme.	EHDAA2:0002050|EMAPA:17729	hp.json	toe 3 metatarsal pre-cartilage condensation|pedal digit III metatarsal pre-cartilage condensation|foot digit 3 metatarsal pre-cartilage condensation|hind limb digit 3 metatarsal pre-cartilage condensation	http://purl.obolibrary.org/obo/UBERON_0010549		
UBERON:0009564	biolink:AnatomicalEntity	distal limb integumentary appendage	A nail, hoof or claw.	MESH:D006724	hp.json	keratin plate|keratin sheath|hoof, claw or nail|unguis|hoof or claw	http://purl.obolibrary.org/obo/UBERON_0009564		
UBERON:0009565	biolink:AnatomicalEntity	nail of manual digit	A nail that is part of a manual digit.	FMA:54327|NCIT:C32609|EMAPA:35349|UMLS:C0222001	hp.json	nail plate of finger|nail of finger|manual claw|claw of hand|forelimb digit claw|fingernail|finger nail|claw of manus	http://purl.obolibrary.org/obo/UBERON_0009565		pheno_slim
UBERON:0009566	biolink:AnatomicalEntity	intestinal submucosa	A submucosa that is part of a intestine.	FMA:15696	hp.json	submucosa of intestine	http://purl.obolibrary.org/obo/UBERON_0009566		
UBERON:0009567	biolink:AnatomicalEntity	nail of pedal digit	A nail that is part of a pedal digit.	EMAPA:36457|UMLS:C0222007|XAO:0003103|FMA:54328|NCIT:C33790	hp.json	toe nail|nail of toe|nail of pes|hindlimb digit claw|claw of pes|claw of foot|pedal claw|nail plate of toe|hindlimb claw|toenail|claw of toe	http://purl.obolibrary.org/obo/UBERON_0009567		pheno_slim
CL:0009063	biolink:Cell	enteroendocrine cell of anorectum	An enteroendocrine cell that is located in the anorectum.		hp.json	anorectum enteroendocrine cell	http://purl.obolibrary.org/obo/CL_0009063		location_grouping
CHEBI:27081	biolink:ChemicalSubstance	transition element atom	An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell.		hp.json	transition element|Uebergangsmetalle|metaux de transition|transition metal|metal de transicion|Uebergangselement|metal de transition|metales de transicion|transition metals|transition elements|transition element	http://purl.obolibrary.org/obo/CHEBI_27081		3_STAR
GO:0015774	biolink:BiologicalProcess	polysaccharide transport	The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.		hp.json		http://purl.obolibrary.org/obo/GO_0015774		
CHEBI:27092	biolink:ChemicalSubstance	tricarboxylic acid trianion			hp.json	tricarboxylate|tricarboxylates|tricarboxylic acid trianions	http://purl.obolibrary.org/obo/CHEBI_27092		3_STAR
CHEBI:27093	biolink:ChemicalSubstance	tricarboxylic acid	An oxoacid containing three carboxy groups.	Wikipedia:Tricarboxylic_acid	hp.json	Tricarbonsaeure|tricarboxylic acids|Trikarbonsaeure	http://purl.obolibrary.org/obo/CHEBI_27093		3_STAR
CHEBI:78675	biolink:ChemicalSubstance	fundamental metabolite	Any metabolite produced by all living cells.		hp.json	fundamental metabolites|essential metabolite|essential metabolites	http://purl.obolibrary.org/obo/CHEBI_78675		3_STAR
CL:0009066	biolink:Cell	stratified squamous epithelial cell of anal canal	A stratified squamous epithelial cell that is part of the anal canal.		hp.json	anal canal stratified squamous epithelial cell	http://purl.obolibrary.org/obo/CL_0009066		location_grouping
CL:0009040	biolink:Cell	stromal cell of lamina propria of colon	A stromal cell found in the lamina propria of the colon.		hp.json	stromal cell of colon lamina propria	http://purl.obolibrary.org/obo/CL_0009040		location_grouping
CL:0009042	biolink:Cell	enteroendocrine cell of colon	An enteroendocrine cell that is located in the colon.		hp.json	colon enteroendocrine cell	http://purl.obolibrary.org/obo/CL_0009042		location_grouping
CHEBI:64049	biolink:ChemicalSubstance	food acidity regulator	A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents.	Wikipedia:Acidity_regulator	hp.json	pH control agent|pH control agents|food acidity regulators|acidity regulator|acidity regulators	http://purl.obolibrary.org/obo/CHEBI_64049		3_STAR
CHEBI:64047	biolink:ChemicalSubstance	food additive	Any substance which is added to food to preserve or enhance its flavour and/or appearance.	Wikipedia:Food_additive	hp.json	food additives	http://purl.obolibrary.org/obo/CHEBI_64047		3_STAR
CL:0009038	biolink:Cell	colon macrophage	A macrophage that is located in the colon.		hp.json	macrophage of colon	http://purl.obolibrary.org/obo/CL_0009038		location_grouping
CL:0009051	biolink:Cell	T cell of anorectum	A T cell that is located in the anorectum.		hp.json		http://purl.obolibrary.org/obo/CL_0009051		location_grouping
CL:0009052	biolink:Cell	smooth muscle cell of anorectum	A smooth muscle cell that is located in the anorectum.		hp.json	anorectum smooth muscle cell	http://purl.obolibrary.org/obo/CL_0009052		location_grouping
CL:0009053	biolink:Cell	stromal cell of anorectum lamina propria	A stromal cell found in the lamina propria of the anorectum.		hp.json		http://purl.obolibrary.org/obo/CL_0009053		location_grouping
CL:0010021	biolink:Cell	cardiac myoblast			hp.json		http://purl.obolibrary.org/obo/CL_0010021		
CL:0010022	biolink:Cell	cardiac neuron			hp.json		http://purl.obolibrary.org/obo/CL_0010022		
CL:0010020	biolink:Cell	cardiac glial cell			hp.json		http://purl.obolibrary.org/obo/CL_0010020		
CL:0009048	biolink:Cell	anorectum macrophage	A macrophage that is located in the anorectum.		hp.json	macrophage of anorectum	http://purl.obolibrary.org/obo/CL_0009048		location_grouping
CL:0010012	biolink:Cell	cerebral cortex neuron	A CNS neuron of the cerebral cortex.	BTO:0004102|FMA:84104	hp.json	neuron of cerebral cortex|cortical neuron	http://purl.obolibrary.org/obo/CL_0010012		
CL:0000680	biolink:Cell	muscle precursor cell	A non-terminally differentiated cell that is capable of developing into a muscle cell.		hp.json		http://purl.obolibrary.org/obo/CL_0000680		
CL:0000681	biolink:Cell	radial glial cell	A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration.		hp.json	forebrain radial glial cell	http://purl.obolibrary.org/obo/CL_0000681		
UBERON:0009636	biolink:AnatomicalEntity	prechordal cartilage	Chondrocranium chondrification center that that forms anterior body of sphenoid, containing the sella turcica and posterior body of sphenoid.		hp.json		http://purl.obolibrary.org/obo/UBERON_0009636		
UBERON:0009638	biolink:AnatomicalEntity	orbitosphenoid ossification center			hp.json	orbitosphenoid center	http://purl.obolibrary.org/obo/UBERON_0009638		
CL:0009018	biolink:Cell	lymphocyte of large intestine lamina propria	A lymphocyte that resides in the lamina propria of the large intestine.		hp.json	lamina propria lymphocyte of large intestine	http://purl.obolibrary.org/obo/CL_0009018		location_grouping
CHEBI:76042	biolink:ChemicalSubstance	aromatic amino-acid zwitterion	An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any aromatic amino-acid.	MetaCyc:Aromatic-Amino-Acids	hp.json	aromatic amino-acid zwitterions|an aromatic amino-acid	http://purl.obolibrary.org/obo/CHEBI_76042		3_STAR
UBERON:0009639	biolink:AnatomicalEntity	body of sphenoid	The body of the sphenoid bone, more or less cubical in shape, is hollowed out in its interior to form two large cavities, the sphenoidal air sinuses, which are separated from each other by a septum.	FMA:52867	hp.json	body of sphenoidal bone|corpus (os sphenoidale)|corpus ossis sphenoidalis|Entire body of sphenoid bone|sphenoid body|central body of sphenoid	http://purl.obolibrary.org/obo/UBERON_0009639		
CL:0010017	biolink:Cell	zygote	A zygote in a plant or an animal.		hp.json		http://purl.obolibrary.org/obo/CL_0010017		
CHEBI:39015	biolink:ChemicalSubstance	apolipoprotein	Protein component on the surface of lipoprotein.		hp.json	apolipoproteins	http://purl.obolibrary.org/obo/CHEBI_39015		3_STAR
GO:0001101	biolink:BiologicalProcess	response to acid chemical	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.		hp.json	response to acid anion|response to acid|response to oxoanion	http://purl.obolibrary.org/obo/GO_0001101		gocheck_do_not_manually_annotate
CL:0010003	biolink:Cell	epithelial cell of alveolus of lung	An epithelial cell that is part_of a alveolus of lung.		hp.json	alveolus of lung epithelial cell	http://purl.obolibrary.org/obo/CL_0010003		
GO:1990280	biolink:BiologicalProcess	RNA localization to chromatin	A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.		hp.json	RNA localisation to chromatin	http://purl.obolibrary.org/obo/GO_1990280		
CL:0010004	biolink:Cell	mononuclear cell of bone marrow	A mononuclear cell that is part_of a bone marrow.		hp.json	bone marrow mononuclear cell	http://purl.obolibrary.org/obo/CL_0010004		
CL:0010001	biolink:Cell	stromal cell of bone marrow	A stromal cell that is part_of a bone marrow.		hp.json	bone marrow stromal cell	http://purl.obolibrary.org/obo/CL_0010001		
GO:0015749	biolink:BiologicalProcess	monosaccharide transmembrane transport	The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.		hp.json	monosaccharide transport	http://purl.obolibrary.org/obo/GO_0015749		
UBERON:0009624	biolink:AnatomicalEntity	lumbar nerve	The lumbar nerves are the five spinal nerves emerging from the lumbar vertebrae. They are divided into posterior and anterior divisions.	FMA:5861|NCIT:C33015|UMLS:C0228897	hp.json	lumbar spinal nerve|nervus lumbalis|nervi lumbales	http://purl.obolibrary.org/obo/UBERON_0009624		
UBERON:0009625	biolink:AnatomicalEntity	sacral nerve	The five sacral nerves emerge from the sacrum. Although the vertebral components of the sacrum are fused into a single bone, the sacral vertebrae are still used to number the sacral nerves. Posteriorly, they emerge from the posterior sacral foramina, and form the posterior branches of sacral nerves. Anteriorly, they emerge from the anterior sacral foramina, and contribute to the sacral plexus (S1-S4) and coccygeal plexus.	FMA:5862|UMLS:C0228922|NCIT:C33505	hp.json	nervi sacrales|nervus sacralis|sacral spinal nerve	http://purl.obolibrary.org/obo/UBERON_0009625		
CL:0010009	biolink:Cell	camera-type eye photoreceptor cell			hp.json	camera type eye photoreceptor cell	http://purl.obolibrary.org/obo/CL_0010009		
CL:0010007	biolink:Cell	His-Purkinje system cell			hp.json		http://purl.obolibrary.org/obo/CL_0010007		
CL:0000696	biolink:Cell	PP cell	A cell that stores and secretes pancreatic polypeptide hormone.	FMA:62938|FMA:83409	hp.json	type F enteroendocrine cell	http://purl.obolibrary.org/obo/CL_0000696		
CL:0010008	biolink:Cell	cardiac endothelial cell			hp.json		http://purl.obolibrary.org/obo/CL_0010008		
CL:0010006	biolink:Cell	cardiac blood vessel endothelial cell			hp.json		http://purl.obolibrary.org/obo/CL_0010006		
CHEBI:30697	biolink:ChemicalSubstance	beta-D-glucosyl group	A D-glucosyl group obtained by removing the hydroxy group from the hemiacetal function of beta-D-glucose and, by extension, of a lower oligosaccharide having beta-D-glucose at the reducing end. The unsubstituted parent of the class of beta-D-glucosyl groups.	PMID:28979944	hp.json	beta-D-glucosyl group|beta-D-glucosyl|beta-glucopyranosyl group|beta-D-glucopyranosyl|beta-glucosyl|beta-D-glucopyranosyl group	http://purl.obolibrary.org/obo/CHEBI_30697		3_STAR
CL:0009025	biolink:Cell	mesothelial cell of colon	A mesothelial cell that is part of the colon.		hp.json	mesothelial cell of large intestine	http://purl.obolibrary.org/obo/CL_0009025		location_grouping
CHEBI:39022	biolink:ChemicalSubstance	inclusion compound	A complex in which one component (the host) forms a cavity or, in the case of a crystal, a crystal lattice containing spaces in the shape of long tunnels or channels in which molecular entities of a second chemical species (the guest) are located. There is no covalent bonding between guest and host, the attraction being generally due to van der Waals forces.		hp.json	compuestos de inclusion|inclusion compounds|inclusion compound|compuesto de inclusion|inclusion complex|compose d'inclusion	http://purl.obolibrary.org/obo/CHEBI_39022		3_STAR
CL:0009021	biolink:Cell	stromal cell of lamina propria of large intestine	A stromal cell found in the lamina propria of the large intestine.		hp.json		http://purl.obolibrary.org/obo/CL_0009021		location_grouping
CHEBI:39026	biolink:ChemicalSubstance	low-density lipoprotein	A class of lipoproteins of small size (18-25 nm) and low density (1.019-1.063 g/ml) particles with a core composed mainly of cholesterol esters and smaller amounts of triglycerides. The surface monolayer consists mostly of phospholipids, a single copy of apolipoprotein B-100, and free cholesterol molecules. The main function of LDL is to transport cholesterol and cholesterol esters from the liver. Excessive levels are associated with cardiovascular disease.	PMID:19349632|PMID:28432662|PMID:15583011|PMID:28847800|PMID:28792690|PMID:15913955|PMID:28859941|PMID:28401639|Wikipedia:Low-density_lipoprotein|PMID:28827781|PMID:28870972|PMID:11082530	hp.json	low-density lipoproteins|beta-lipoproteins|LDL	http://purl.obolibrary.org/obo/CHEBI_39026		3_STAR
UBERON:0009621	biolink:AnatomicalEntity	tail somite	A somite that is part of a tail.	EMAPA:16860|XAO:0003143|AAO:0010383	hp.json		http://purl.obolibrary.org/obo/UBERON_0009621		
CHEBI:39024	biolink:ChemicalSubstance	clathrate compound	Inclusion compound in which the guest molecule is in a cage formed by the host molecule or by a lattice of host molecules.		hp.json	clathrates|Clathrat|clatrato|Clathratverbindung|clathrate compounds|compuesto de clatrato|Klathrat|cage compound|Klathratverbindung|clatratos|clathrate	http://purl.obolibrary.org/obo/CHEBI_39024		3_STAR
CL:0000667	biolink:Cell	collagen secreting cell	An extracellular matrix secreting cell that secretes collagen.		hp.json		http://purl.obolibrary.org/obo/CL_0000667		
CL:0000669	biolink:Cell	pericyte cell	An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.	BTO:0002441|FMA:63174	hp.json	pericyte of Rouget|cell of Rouget|pericyte|ARC|adventitial reticular cell|adventitial cell	http://purl.obolibrary.org/obo/CL_0000669		
GO:0015718	biolink:BiologicalProcess	monocarboxylic acid transport	The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0015718		
GO:0015711	biolink:BiologicalProcess	organic anion transport	The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.		hp.json		http://purl.obolibrary.org/obo/GO_0015711		
UBERON:0009614	biolink:AnatomicalEntity	hindbrain neural plate	A neural plate that develops_from a presumptive hindbrain.	ZFA:0007022|TAO:0007022	hp.json		http://purl.obolibrary.org/obo/UBERON_0009614		
UBERON:0009615	biolink:AnatomicalEntity	midbrain hindbrain boundary neural plate		TAO:0007044|ZFA:0007044	hp.json	MHB neural plate|midbrain-hindbrain boundary neural plate|MHB neural plate	http://purl.obolibrary.org/obo/UBERON_0009615		
UBERON:0009616	biolink:AnatomicalEntity	presumptive midbrain	A presumptive structure that has the potential to develop into a midbrain.	EHDAA2:0000615|ZFA:0000148|TAO:0000148|EMAPA:16140|BAMS:MES|Wikipedia:Mesencephalon|EFO:0003432	hp.json	early midbrain|future midbrain|early midbrain|future midbrain|presumptive mesencephalon|mesencephalon	http://purl.obolibrary.org/obo/UBERON_0009616		efo_slim
UBERON:0009617	biolink:AnatomicalEntity	head paraxial mesoderm	Bilateral mesenchymal mesoderm parallel and immediately adjacent to the neural tube/notochord; it generates a subset of extra-ocular, and other head, muscles.	EHDAA2:0000736|EHDAA:364|EMAPA:16171	hp.json	head paraxial mesenchyme|head paraxial mesenchyme|cranial paraxial mesoderm|cephalic paraxial mesenchyme|cranial paraxial mesenchyme|cephalic paraxial mesoderm|somitomeric mesoderm|somitomere|cranial paraxial mesenchyme|cephalic paraxial mesoderm|cranial paraxial mesoderm|cephalic paraxial mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009617		
UBERON:0009618	biolink:AnatomicalEntity	trunk paraxial mesoderm		EHDAA2:0002094	hp.json	trunk and cervical paraxial mesenchyme|trunk paraxial mesenchyme|trunk paraxial mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009618		
CHEBI:30661	biolink:ChemicalSubstance	thyronine	A tyrosine derivative where the phenolic hydrogen of tyrosine is substituted by 4-hydroxyphenyl.	CAS:1034-10-2|Reaxys:2947040|Beilstein:2947040|PMID:15643926|Gmelin:419747	hp.json	thyronine|2-amino-3-[4-(4-hydroxyphenoxy)phenyl]propanoic acid|O-(4-hydroxyphenyl)-DL-tyrosine	http://purl.obolibrary.org/obo/CHEBI_30661		3_STAR
CHEBI:30660	biolink:ChemicalSubstance	thyroxine	An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	Beilstein:2228514|PMID:15206581|PMID:9824273|PMID:24375501|CAS:300-30-1	hp.json	Thx|O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-DL-tyrosine|thyroxine|DL-Thyroxine|2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid	http://purl.obolibrary.org/obo/CHEBI_30660		3_STAR
UBERON:0009610	biolink:AnatomicalEntity	forebrain neural plate	A neural plate that develops_from a future forebrain.	ZFA:0007018|TAO:0007018	hp.json		http://purl.obolibrary.org/obo/UBERON_0009610		
UBERON:0009611	biolink:AnatomicalEntity	midbrain neural plate	A neural plate that develops_from a presumptive midbrain.	ZFA:0007019|TAO:0007019	hp.json		http://purl.obolibrary.org/obo/UBERON_0009611		
CHEBI:27027	biolink:ChemicalSubstance	micronutrient	Any nutrient required in small quantities by organisms throughout their life in order to orchestrate a range of physiological functions.	Wikipedia:Micronutrient	hp.json	micronutrients|trace elements	http://purl.obolibrary.org/obo/CHEBI_27027		3_STAR
GO:1904306	biolink:BiologicalProcess	positive regulation of gastro-intestinal system smooth muscle contraction	Any process that activates or increases the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.		hp.json	activation of gastro-intestinal system smooth muscle contraction|upregulation of gastro-intestinal system smooth muscle contraction|up regulation of gastro-intestinal system smooth muscle contraction|up-regulation of gastro-intestinal system smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904306		
CHEBI:27024	biolink:ChemicalSubstance	toluenes	Any member of the class of benzenes that is a substituted benzene in which the substituents include one (and only one) methyl group.		hp.json		http://purl.obolibrary.org/obo/CHEBI_27024		3_STAR
GO:1904305	biolink:BiologicalProcess	negative regulation of gastro-intestinal system smooth muscle contraction	Any process that stops, prevents or reduces the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.		hp.json	down regulation of gastro-intestinal system smooth muscle contraction|inhibition of gastro-intestinal system smooth muscle contraction|down-regulation of gastro-intestinal system smooth muscle contraction|downregulation of gastro-intestinal system smooth muscle contraction	http://purl.obolibrary.org/obo/GO_1904305		
CL:0000679	biolink:Cell	glutamatergic neuron		WBbt:0006829	hp.json		http://purl.obolibrary.org/obo/CL_0000679		
CHEBI:27026	biolink:ChemicalSubstance	toxin	Poisonous substance produced by a biological organism such as a microbe, animal or plant.	Wikipedia:Toxin	hp.json	toxin|toxins	http://purl.obolibrary.org/obo/CHEBI_27026		3_STAR
GO:1904304	biolink:BiologicalProcess	regulation of gastro-intestinal system smooth muscle contraction	Any process that modulates the frequency, rate or extent of gastro-intestinal system smooth muscle contraction.		hp.json		http://purl.obolibrary.org/obo/GO_1904304		
UBERON:0009602	biolink:AnatomicalEntity	left lung associated mesenchyme	Mesenchyme that is part of a developing left lung.	EHDAA2:0000944|EMAPA:16730|EMAPA:17654	hp.json	left lung mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009602		
CL:0000670	biolink:Cell	primordial germ cell	A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells.	FMA:70567	hp.json	gonocyte|primitive germ cell	http://purl.obolibrary.org/obo/CL_0000670		
UBERON:0009603	biolink:AnatomicalEntity	right lung associated mesenchyme	Mesenchyme that is part of a developing right lung.	EMAPA:17662|EHDAA2:0001739	hp.json	right lung mesenchyme	http://purl.obolibrary.org/obo/UBERON_0009603		
CL:0000675	biolink:Cell	female gamete	A mature sexual reproductive cell of the female germline.		hp.json		http://purl.obolibrary.org/obo/CL_0000675		
GO:0015721	biolink:NamedThing	bile acid and bile salt transport			hp.json		http://purl.obolibrary.org/obo/GO_0015721		
CL:0009004	biolink:Cell	retinal cell	Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.	PMID:10702418	hp.json		http://purl.obolibrary.org/obo/CL_0009004		
CL:0009000	biolink:Cell	sensory neuron of spinal nerve	A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord.		hp.json	spinal sensory neuron	http://purl.obolibrary.org/obo/CL_0009000		
CL:0009001	biolink:Cell	compound eye retinal cell	Any cell in the compound eye, a light sensing organ composed of ommatidia.	GOC:pr|PMID:12021768	hp.json		http://purl.obolibrary.org/obo/CL_0009001		
HP:0012462	biolink:PhenotypicFeature	Chin myoclonus	Involuntary and irregular twitches of the chin.	UMLS:C1860972|MSH:C537682	hp.json	Geniospasm|Chin spasms	http://purl.obolibrary.org/obo/HP_0012462		
GO:1990234	biolink:CellularComponent	transferase complex	A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).		hp.json		http://purl.obolibrary.org/obo/GO_1990234		
HP:0012463	biolink:PhenotypicFeature	Elevated transferrin saturation	An above normal level of saturation of serum transferrin with iron.	UMLS:C4022892	hp.json		http://purl.obolibrary.org/obo/HP_0012463		
HP:0012464	biolink:PhenotypicFeature	Decreased transferrin saturation	A below normal level of saturation of serum transferrin with iron.	UMLS:C0919785	hp.json		http://purl.obolibrary.org/obo/HP_0012464		
HP:0012465	biolink:PhenotypicFeature	Elevated hepatic iron concentration	An increased level of iron in liver tissues.	UMLS:C4022891	hp.json	Increased iron concentration in liver|Increased liver iron level	http://purl.obolibrary.org/obo/HP_0012465		
HP:0012466	biolink:PhenotypicFeature	Chronic respiratory acidosis	Longstanding impairment in ventilation such that the partial pressure of carbon dioxide (PaCO2) is elevated above the upper limit of the reference range (more than 45 mm Hg), with a normal or near-normal pH secondary to renal compensation and an elevated serum bicarbonate levels (more than30 mEq/L).	UMLS:C0268048|SNOMEDCT_US:8764008	hp.json		http://purl.obolibrary.org/obo/HP_0012466		
HP:0012467	biolink:PhenotypicFeature	Acute respiratory acidosis	Sudden onset of impairment in ventilation such that the removal of carbon dioxide by the respiratory system is less than the production of carbon dioxide in the tissues, leading to an elevation of the partial pressure of carbon dioxide (PaCO2) above the normal limits (more than 45 mm Hg) with an accompanying acidemia (pH less than 7.35).	SNOMEDCT_US:70644008|UMLS:C0268047	hp.json		http://purl.obolibrary.org/obo/HP_0012467		
HP:0012468	biolink:PhenotypicFeature	Chronic acidosis	Longstanding abnormal acid accumulation or depletion of base.	UMLS:C1735903	hp.json		http://purl.obolibrary.org/obo/HP_0012468		
HP:0012469	biolink:PhenotypicFeature	Infantile spasms	Infantile spasms represent a subset of "epileptic spasms". Infantile Spasms are epileptic spasms starting in the first year of life (infancy).	UMLS:C3887898	hp.json		http://purl.obolibrary.org/obo/HP_0012469		
HP:0012460	biolink:PhenotypicFeature	Dysmorphic inferior cerebellar vermis	A structural anomaly of the inferior portion of the vermis of cerebellum.	UMLS:C4022893	hp.json		http://purl.obolibrary.org/obo/HP_0012460		
HP:0012461	biolink:PhenotypicFeature	Bacteriuria	The presence of bacteria in the urine.	UMLS:C0004659|SNOMEDCT_US:61373006|MSH:D001437	hp.json	Bacteria in urine|High urine bacteria	http://purl.obolibrary.org/obo/HP_0012461		
HP:0000473	biolink:PhenotypicFeature	Torticollis	Involuntary contractions of the neck musculature resulting in an abnormal posture of or abnormal movements of the head.	UMLS:C0152116|UMLS:C0949445|SNOMEDCT_US:70070008|MSH:D014103|UMLS:C0040485|SNOMEDCT_US:270476009|SNOMEDCT_US:74333002	hp.json	Cervical dystonia|Spasmodic torticollis|Wry neck|Loxia	http://purl.obolibrary.org/obo/HP_0000473		
HP:0000472	biolink:PhenotypicFeature	Long neck	Increased inferior-superior length of the neck.	UMLS:C1839816	hp.json	Long neck|Increased cervical length|Elongated neck|Increased length of neck|Cervical elongation	http://purl.obolibrary.org/obo/HP_0000472		hposlim_core
HP:0000475	biolink:PhenotypicFeature	Broad neck	Increased side-to-side width of the neck.	UMLS:C1853638	hp.json	Increased width of neck|Thick neck|Broad neck|Wide neck	http://purl.obolibrary.org/obo/HP_0000475		hposlim_core
BFO:0000050	biolink:NamedThing	part of	a core relation that holds between a part and its whole	BFO:0000050	hp.json		http://purl.obolibrary.org/obo/BFO_0000050		http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_gp2term|http://purl.obolibrary.org/obo/valid_for_go_ontology
HP:0000474	biolink:PhenotypicFeature	Thickened nuchal skin fold	A thickening of the skin thickness in the posterior aspect of the fetal neck. A nuchal fold (NF) measurement is obtained in a transverse section of the fetal head at the level of the cavum septum pellucidum and thalami, angled posteriorly to include the cerebellum. The measurement is taken from the outer edge of the occiput bone to the outer skin limit directly in the midline. An NF measurement greater than 5 mm at 14 to 17+6 weeks of gestation, or 6 mm at 18 to 28 weeks has been associated with a markedly increased risk for Down syndrome.	UMLS:C1836940	hp.json	Increased nuchal fold thickness|Increased nuchal fold|Excess nuchal skin|Thickened skin over the neck|Thickened skin folds of neck|Thick nuchal fold|Thickened nuchal skin	http://purl.obolibrary.org/obo/HP_0000474		hposlim_core
HP:0000476	biolink:PhenotypicFeature	Cystic hygroma	A cystic lymphatic lesion of the neck.	MSH:D018191|SNOMEDCT_US:423984004|SNOMEDCT_US:40225001|SNOMEDCT_US:399882002|NCIT:C8965|UMLS:C0206620	hp.json	Cystic hygroma of the neck	http://purl.obolibrary.org/obo/HP_0000476		
HP:0000479	biolink:PhenotypicFeature	Abnormal retinal morphology	A structural abnormality of the retina.	UMLS:C0035309|SNOMEDCT_US:29555009|MSH:D012164|UMLS:C0035300	hp.json	Abnormal retina|Retina issue|Retinal disease|Abnormality of the retina|Anomaly of the retina	http://purl.obolibrary.org/obo/HP_0000479		hposlim_core
HP:0000478	biolink:PhenotypicFeature	Abnormality of the eye	Any abnormality of the eye, including location, spacing, and intraocular abnormalities.	SNOMEDCT_US:371405004|UMLS:C0015393|SNOMEDCT_US:371409005|MSH:D005128|SNOMEDCT_US:19416009|MSH:D005124|UMLS:C0015397	hp.json	Eye disease|Abnormal eye|Abnormality of the eye	http://purl.obolibrary.org/obo/HP_0000478		hposlim_core
BFO:0000051	biolink:NamedThing	has part	Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2.	BFO:0000051	hp.json		http://purl.obolibrary.org/obo/BFO_0000051		http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_ontology
GO:1990239	biolink:MolecularActivity	steroid hormone binding	Binding to a steroid hormone.		hp.json		http://purl.obolibrary.org/obo/GO_1990239		
HP:0000471	biolink:PhenotypicFeature	Gastrointestinal angiodysplasia	Dysplasia affecting the vasculature of the gastrointestinal tract.	UMLS:C0854242	hp.json	GI angiodysplasia	http://purl.obolibrary.org/obo/HP_0000471		
HP:0000470	biolink:PhenotypicFeature	Short neck	Diminished length of the neck.	UMLS:C0521525|SNOMEDCT_US:95427009	hp.json	Decreased length of neck|Cervical shortening|Decreased cervical height|Decreased cervical length|Short neck	http://purl.obolibrary.org/obo/HP_0000470		hposlim_core
HP:0012451	biolink:PhenotypicFeature	Acute constipation	Constipation of sudden onset and lasting for less than three months.	UMLS:C0401148|SNOMEDCT_US:197119006	hp.json		http://purl.obolibrary.org/obo/HP_0012451		
HP:0012452	biolink:PhenotypicFeature	Restless legs	A feeling of uneasiness and restlessness in the legs after going to bed (sometimes causing insomnia).	SNOMEDCT_US:32914008|MSH:D012148|UMLS:C0035258	hp.json	Wittmaack-Ekbom syndrome|Willis-Ekbom disease|Restless legs syndrome	http://purl.obolibrary.org/obo/HP_0012452		
HP:0012453	biolink:PhenotypicFeature	Bilateral wrist flexion contracture	A chronic loss of wrist joint motion on the right and left sides.	UMLS:C4020723|UMLS:C4022899	hp.json	Bilateral wrist contracture	http://purl.obolibrary.org/obo/HP_0012453		
HP:0012454	biolink:PhenotypicFeature	Unilateral wrist flexion contracture	A chronic loss of wrist joint motion on one side only.	UMLS:C4020722|UMLS:C4022898	hp.json	Unilateral wrist contracture	http://purl.obolibrary.org/obo/HP_0012454		
HP:0012455	biolink:PhenotypicFeature	obsolete Large artery calcification			hp.json		http://purl.obolibrary.org/obo/HP_0012455		
HP:0012456	biolink:PhenotypicFeature	Medial arterial calcification	Calcification, that is, pathological deposition of calcium salts in the tunica media of arteries.	UMLS:C4022896	hp.json		http://purl.obolibrary.org/obo/HP_0012456		
HP:0012457	biolink:PhenotypicFeature	Medial calcification of medium-sized arteries	Calcification, that is, pathological deposition of calcium salts in the tunica media of medium-sized (muscular or distributive) arteries.	UMLS:C4022895	hp.json		http://purl.obolibrary.org/obo/HP_0012457		
HP:0012458	biolink:PhenotypicFeature	Medial calcification of small arteries	Calcification, that is, pathological deposition of calcium salts in the tunica media of small arteries.	UMLS:C4022894	hp.json		http://purl.obolibrary.org/obo/HP_0012458		
HP:0012450	biolink:PhenotypicFeature	Chronic constipation	Constipation for longer than three months with fewer than 3 bowel movements per week, straining, lumpy or hard stools, and a sensation of anorectal obstruction or incomplete defecation.	UMLS:C0401149|SNOMEDCT_US:236069009	hp.json	Infrequent bowel movements|Chronic constipation	http://purl.obolibrary.org/obo/HP_0012450		
HP:0000484	biolink:PhenotypicFeature	Hyperopic astigmatism	A form of astigmatism in which one meridian is hyperopic while the one at a right angle to it has no refractive error.	SNOMEDCT_US:449734001|UMLS:C1847524	hp.json		http://purl.obolibrary.org/obo/HP_0000484		
HP:0000483	biolink:PhenotypicFeature	Astigmatism	A type of astigmatism associated with abnormal curvatures on the anterior and/or posterior surface of the cornea.	UMLS:C0004106|MSH:D001251|SNOMEDCT_US:82649003	hp.json	Astigmatism|Abnormal curving of the cornea or lens of the eye	http://purl.obolibrary.org/obo/HP_0000483		hposlim_core
HP:0000486	biolink:PhenotypicFeature	Strabismus	A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error.	SNOMEDCT_US:22066006|MSH:D013285|SNOMEDCT_US:128602000|UMLS:C0038379	hp.json	Squint|Cross-eyed|Squint eyes	http://purl.obolibrary.org/obo/HP_0000486		hposlim_core
HP:0000485	biolink:PhenotypicFeature	Megalocornea	An enlargement of the cornea with normal clarity and function. Megalocornea is diagnosed with a horizontal corneal diameter of 12 mm or more at birth or 13 mm or more after two years of age.	UMLS:C1167712|SNOMEDCT_US:204118005|MSH:C562829|UMLS:C0344530|SNOMEDCT_US:268158009	hp.json	Macrocornea|Anterior megalophthalmos|Enlarged cornea|Increased corneal diameter	http://purl.obolibrary.org/obo/HP_0000485		hposlim_core
HP:0000488	biolink:PhenotypicFeature	Retinopathy	Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality.	SNOMEDCT_US:29555009|MSH:D012164|UMLS:C0035309	hp.json	Noninflammatory retina disease	http://purl.obolibrary.org/obo/HP_0000488		hposlim_core
HP:0000487	biolink:PhenotypicFeature	obsolete Congenital strabismus			hp.json		http://purl.obolibrary.org/obo/HP_0000487		
HP:0000489	biolink:PhenotypicFeature	obsolete Abnormality of globe location or size			hp.json		http://purl.obolibrary.org/obo/HP_0000489		
HP:0012459	biolink:PhenotypicFeature	Hypnic headache	A headache disorder that occurs exclusively at night, waking the affected individual from sleep.	SNOMEDCT_US:122711000119109|UMLS:C0752150|MSH:D051270	hp.json	Alarm clock headache	http://purl.obolibrary.org/obo/HP_0012459		
HP:0000480	biolink:PhenotypicFeature	Retinal coloboma	A notch or cleft of the retina.	UMLS:C3540764	hp.json	Hole in the back of the eye	http://purl.obolibrary.org/obo/HP_0000480		hposlim_core
BFO:0000040	biolink:NamedThing	material entity	An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.		hp.json		http://purl.obolibrary.org/obo/BFO_0000040		
HP:0000482	biolink:PhenotypicFeature	Microcornea	A congenital abnormality of the cornea in which the cornea and the anterior segment of the eye are smaller than normal. The horizontal diameter of the cornea does not reach 10 mm even in adulthood.	SNOMEDCT_US:26098002|UMLS:C0266544|UMLS:C1167713	hp.json	Decreased corneal diameter|Cornea of eye less than 10mm in diameter	http://purl.obolibrary.org/obo/HP_0000482		hposlim_core
HP:0000481	biolink:PhenotypicFeature	Abnormal cornea morphology	Any abnormality of the cornea, which is the transparent tissue at the front of the eye that covers the iris, pupil, and anterior chamber.	UMLS:C4020889|UMLS:C1855670	hp.json	Corneal abnormality|Corneal abnormalities|Cornela disease|Abnormality of the cornea	http://purl.obolibrary.org/obo/HP_0000481		hposlim_core
HP:0012440	biolink:PhenotypicFeature	Abnormal biliary tract morphology	A structural abnormality of the biliary tree.	UMLS:C4021086	hp.json	Anomaly of the biliary tract	http://purl.obolibrary.org/obo/HP_0012440		
HP:0012441	biolink:PhenotypicFeature	Sphincter of Oddi dyskinesia	Reduced motility through the sphincter of Oddi, resulting in impedance of bile and pancreatic juice flow from the common bile duct into the duodenum.	UMLS:C4048750|MSH:D046628|SNOMEDCT_US:430887001|UMLS:C0878588	hp.json	Sphincter of Oddi dysfunction	http://purl.obolibrary.org/obo/HP_0012441		
HP:0012442	biolink:PhenotypicFeature	Gallbladder dyskinesia	Reduced motility of the gallbladder with reduced emptying fraction.	MSH:D001657|UMLS:C1449631	hp.json		http://purl.obolibrary.org/obo/HP_0012442		
HP:0012443	biolink:PhenotypicFeature	Abnormality of brain morphology	A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain.	UMLS:C4021085	hp.json	Abnormality of the brain|Abnormal shape of brain	http://purl.obolibrary.org/obo/HP_0012443		
HP:0012444	biolink:PhenotypicFeature	Brain atrophy	Partial or complete wasting (loss) of brain tissue that was once present.	SNOMEDCT_US:278849000|SNOMEDCT_US:52522001|UMLS:C0235946|UMLS:C0154671|SNOMEDCT_US:418143002	hp.json	Brain degeneration|Brain wasting	http://purl.obolibrary.org/obo/HP_0012444		
CHEBI:78608	biolink:ChemicalSubstance	alpha-amino acid zwitterion	An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3.	MetaCyc:Alpha-Amino-Acids	hp.json	an alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_78608		3_STAR
HP:0012446	biolink:PhenotypicFeature	Decreased CSF 5-methyltetrahydrofolate concentration	A reduced concentration of 5-methyltetrahydrofolate(2-) in the cerebrospinal fluid (CSF). 5-methyltetrahydrofolate is the active folate metabolite.	MSH:C567791|SNOMEDCT_US:711403001|UMLS:C2751584|UMLS:C4022901	hp.json	Reduced CSF 5-methyltetrahydrofolate concentration|Cerebral folate deficiency|Low CSF 5-methyltetrahydrofolate	http://purl.obolibrary.org/obo/HP_0012446		
HP:0012447	biolink:PhenotypicFeature	Abnormal myelination	Any anomaly in the process by which myelin sheaths are formed and maintained around neurons.	UMLS:C1857704	hp.json		http://purl.obolibrary.org/obo/HP_0012447		
HP:0000458	biolink:PhenotypicFeature	Anosmia	An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell.	MSH:D000857|SNOMEDCT_US:44169009|UMLS:C0003126	hp.json	Lost smell|Loss of smell	http://purl.obolibrary.org/obo/HP_0000458		hposlim_core
HP:0000451	biolink:PhenotypicFeature	Triangular nasal tip		UMLS:C1839765	hp.json	Triangular nasal tip|Triangular shaped tip of nose	http://purl.obolibrary.org/obo/HP_0000451		
HP:0000453	biolink:PhenotypicFeature	Choanal atresia	Absence or abnormal closure of the choana (the posterior nasal aperture). Most embryologists believe that posterior choanal atresia results from a failure of rupture between the 35th and 38th day of fetal life of the partition which separates the bucconasal or buccopharyngeal membranes. The resultant choanal atresia may be unilateral or bilateral, bony or membranous, complete or incomplete. In over 90 per cent of cases the obstruction is bony, while in the remainder it is membranous. The bony type of atresia is commonly located 1-2 mm. anterior to the posterior edge of the hard palate, and the osseous septum varies in thickness from 1 to 10 mm. In the membranous form of choanal atresia the obstruction usually occurs further posteriorly. In approximately one third of cases the atresia is bilateral.	MSH:D002754|UMLS:C0008297|SNOMEDCT_US:204508009|Fyler:4203	hp.json	Blockage of the rear opening of the nasal cavity	http://purl.obolibrary.org/obo/HP_0000453		hposlim_core
HP:0000452	biolink:PhenotypicFeature	Choanal stenosis	Abnormal narrowing of the choana (the posterior nasal aperture).	UMLS:C0584837|SNOMEDCT_US:306963008	hp.json	Narrowing of the rear opening of the nasal cavity|Coanal stenosis	http://purl.obolibrary.org/obo/HP_0000452		hposlim_core
HP:0000455	biolink:PhenotypicFeature	Broad nasal tip	Increase in width of the nasal tip.	UMLS:C0426429|SNOMEDCT_US:249327002	hp.json	Increased breadth of nasal tip|Nasal tip, wide|Wide tip of nose|Broad tip of nose|Broad upturned nose|Broad nasal tip|Nasal tip, broad|Increased width of tip of nose|Broad, upturned nose|Increased width of nasal tip|Increased breadth of tip of nose	http://purl.obolibrary.org/obo/HP_0000455		
HP:0000454	biolink:PhenotypicFeature	Flared nostrils		SNOMEDCT_US:21558008|SNOMEDCT_US:248568003|UMLS:C0277873	hp.json	Flared nostrils|Flared nasal alae	http://purl.obolibrary.org/obo/HP_0000454		
HP:0000457	biolink:PhenotypicFeature	Depressed nasal ridge	Lack of prominence of the nose resulting from a posteriorly-placed nasal ridge.	UMLS:C1842876	hp.json	Recessed dorsum of nose|Retruded nasal dorsum|Depressed nasal dorsum|Recessed nasal ridge|Flat dorsum of nose|Flat nose|Recessed nasal dorsum|Retruded nasal ridge|Retruded dorsum of nose|Flat nasal dorsum|Depressed dorsum of nose	http://purl.obolibrary.org/obo/HP_0000457		hposlim_core
CHEBI:52090	biolink:ChemicalSubstance	methoxide	An organic anion that is the conjugate base of methanol.	Reaxys:1839368	hp.json	methoxide ion	http://purl.obolibrary.org/obo/CHEBI_52090		3_STAR
HP:0000456	biolink:PhenotypicFeature	Bifid nasal tip	A splitting of the nasal tip. Visually assessable vertical indentation, cleft, or depression of the nasal tip.	SNOMEDCT_US:249326006|UMLS:C4020890|UMLS:C0426428	hp.json	Cleft tip of nose|Notched tip of nose|Notched nasal tip|Bifid tip of nose|Cleft nasal tip	http://purl.obolibrary.org/obo/HP_0000456		
HP:0012448	biolink:PhenotypicFeature	Delayed myelination	Delayed myelination.	UMLS:C1277241|SNOMEDCT_US:135810007	hp.json		http://purl.obolibrary.org/obo/HP_0012448		
HP:0012449	biolink:PhenotypicFeature	Sacroiliac joint synovitis	Inflammation of the synovial membrane of the sacroiliac joint.	UMLS:C4022900	hp.json		http://purl.obolibrary.org/obo/HP_0012449		
GO:1990266	biolink:BiologicalProcess	neutrophil migration	The movement of a neutrophil within or between different tissues and organs of the body.		hp.json		http://purl.obolibrary.org/obo/GO_1990266		
HP:0012430	biolink:PhenotypicFeature	Cerebral white matter hypoplasia	Underdevelopment of the cerebral white matter.	UMLS:C4022908|UMLS:C4020727	hp.json	Paucity of cerebral white matter	http://purl.obolibrary.org/obo/HP_0012430		
CHEBI:78616	biolink:ChemicalSubstance	carbohydrates and carbohydrate derivatives	Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation.		hp.json	carbohydrates and derivatives|carbohydrates and their derivatives	http://purl.obolibrary.org/obo/CHEBI_78616		3_STAR
HP:0012431	biolink:PhenotypicFeature	Episodic fatigue	Intermittent and recurrent bouts of a subjective feeling of tiredness characterized by a lack of energy and motivation.	UMLS:C4022907	hp.json		http://purl.obolibrary.org/obo/HP_0012431		
HP:0012432	biolink:PhenotypicFeature	Chronic fatigue	Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer.	UMLS:C0518656	hp.json	Chronic fatigue|Chronic extreme exhaustion	http://purl.obolibrary.org/obo/HP_0012432		
HP:0012433	biolink:PhenotypicFeature	Abnormal social behavior	An abnormality of actions or reactions of a person taking place during interactions with others.	UMLS:C4021087|UMLS:C4020726	hp.json	Abnormal social behavior|Abnormal social interactions|Abnormal social behaviour	http://purl.obolibrary.org/obo/HP_0012433		
HP:0012434	biolink:PhenotypicFeature	Delayed social development	A failure to meet one or more age-related milestones of social behavior.	UMLS:C4022906	hp.json	Delayed social development	http://purl.obolibrary.org/obo/HP_0012434		
HP:0012435	biolink:PhenotypicFeature	Ventral shortening of foreskin	Reduction in length of the ventral (lower) skin of prepuce of penis.	UMLS:C4022905	hp.json		http://purl.obolibrary.org/obo/HP_0012435		
HP:0012436	biolink:PhenotypicFeature	Nonocclusive coronary artery atherosclerosis	Coronary disease that has not progressed to the point of causing significant occlusion (blockage) of the coronary arteries.	UMLS:C4020724|UMLS:C4020725	hp.json	Non-occlusive coronary artery stenosis|Non-occlusive coronary artery disease|Nonocclusive coronary artery stenosis|Nonocclusive coronary artery disease	http://purl.obolibrary.org/obo/HP_0012436		
HP:0000464	biolink:PhenotypicFeature	Abnormality of the neck	An abnormality of the neck.	UMLS:C4280628|UMLS:C0266623|UMLS:C0575167|SNOMEDCT_US:40052002|SNOMEDCT_US:298390003	hp.json	Anomaly of the neck|Abnormality of the neck|Deformity of the neck|Malformation of the neck	http://purl.obolibrary.org/obo/HP_0000464		hposlim_core
HP:0000463	biolink:PhenotypicFeature	Anteverted nares	Anteriorly-facing nostrils viewed with the head in the Frankfurt horizontal and the eyes of the observer level with the eyes of the subject. This gives the appearance of an upturned nose (upturned nasal tip).	SNOMEDCT_US:708670007|UMLS:C1840077	hp.json	Upturned nasal tip|Upturned nose|Anteverted nostrils|Upturned nasal tips|Upturned nostrils|Upturned nares|Nostrils anteverted|Nasal tip, upturned|Anteverted nose	http://purl.obolibrary.org/obo/HP_0000463		
HP:0000466	biolink:PhenotypicFeature	Limited neck range of motion		UMLS:C1859212	hp.json	Limited neck range of motion|Limited cervical range of motion	http://purl.obolibrary.org/obo/HP_0000466		
HP:0000465	biolink:PhenotypicFeature	Webbed neck	Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline.	UMLS:C0221217|SNOMEDCT_US:11731003	hp.json	Pterygium colli|Neck webbing|Webbed neck	http://purl.obolibrary.org/obo/HP_0000465		hposlim_core
HP:0000468	biolink:PhenotypicFeature	Increased adipose tissue around the neck	An increased amount of subcutaneous fat tissue around the neck.	UMLS:C4025850	hp.json	Increased fat around the neck	http://purl.obolibrary.org/obo/HP_0000468		
HP:0000467	biolink:PhenotypicFeature	Neck muscle weakness	Decreased strength of the neck musculature.	UMLS:C0240479	hp.json	Flaccid neck|Neck muscle weakness|Floppy neck	http://purl.obolibrary.org/obo/HP_0000467		
BFO:0000066	biolink:NamedThing	occurs in	b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t	BFO:0000066	hp.json		http://purl.obolibrary.org/obo/BFO_0000066		http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_ontology
HP:0012437	biolink:PhenotypicFeature	Abnormal gallbladder morphology	A structural anomaly of the gallbladder.	UMLS:C4022904	hp.json	Abnormal shape of gallbladder|Abnormal gallbladder structure	http://purl.obolibrary.org/obo/HP_0012437		
HP:0012438	biolink:PhenotypicFeature	Abnormal gallbladder physiology	A functional anomaly of the gallbladder.	UMLS:C4022903	hp.json		http://purl.obolibrary.org/obo/HP_0012438		
BFO:0000067	biolink:NamedThing	contains process	[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t	BFO:0000067	hp.json		http://purl.obolibrary.org/obo/BFO_0000067		
HP:0012439	biolink:PhenotypicFeature	Abnormal biliary tract physiology	A functional abnormality of the biliary tree.	UMLS:C4022902	hp.json		http://purl.obolibrary.org/obo/HP_0012439		
BFO:0000062	biolink:NamedThing	preceded by	X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X)	BFO:0000062	hp.json	takes place after|is preceded by	http://purl.obolibrary.org/obo/BFO_0000062		ro-eco
BFO:0000063	biolink:NamedThing	precedes	x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.	BFO:0000063	hp.json		http://purl.obolibrary.org/obo/BFO_0000063		ro-eco
HP:0000460	biolink:PhenotypicFeature	Narrow nose	Interalar distance more than 2 SD below the mean for age, or alternatively, an apparently decreased width of the nasal base and alae.	SNOMEDCT_US:249322008|UMLS:C0426422	hp.json	Thin nose|Narrow nose|Decreased nasal width|Decreased nasal breadth	http://purl.obolibrary.org/obo/HP_0000460		
BFO:0000019	biolink:NamedThing	quality			hp.json		http://purl.obolibrary.org/obo/BFO_0000019		
BFO:0000015	biolink:NamedThing	process	An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.		hp.json		http://purl.obolibrary.org/obo/BFO_0000015		
BFO:0000016	biolink:NamedThing	disposition			hp.json		http://purl.obolibrary.org/obo/BFO_0000016		
BFO:0000017	biolink:NamedThing	realizable entity	A specifically dependent continuant  that inheres in continuant  entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances.		hp.json		http://purl.obolibrary.org/obo/BFO_0000017		
HP:0012495	biolink:PhenotypicFeature	Posterior cerebral artery stenosis	Narrowing or constriction of the inner surface (lumen) of the posterior cerebral artery.	UMLS:C1504569	hp.json		http://purl.obolibrary.org/obo/HP_0012495		
HP:0012496	biolink:PhenotypicFeature	Reduced maximal inspiratory pressure	A decrease in the maximum amount of negative pressure a person can generate during an inhalation.	UMLS:C4022880	hp.json		http://purl.obolibrary.org/obo/HP_0012496		
HP:0012497	biolink:PhenotypicFeature	Reduced maximal expiratory pressure	A decrease in the maximum amount of pressure of expired air achieved by a person after a full inspiration.	UMLS:C4022879	hp.json		http://purl.obolibrary.org/obo/HP_0012497		
HP:0012498	biolink:PhenotypicFeature	Nuchal cord	A complication of pregnancy and delivery in which the umbilical cord wraps around the fetal neck once or multiple times.	SNOMEDCT_US:302929008|MSH:D053589|UMLS:C0405124	hp.json		http://purl.obolibrary.org/obo/HP_0012498		
HP:0012499	biolink:PhenotypicFeature	Descending aortic dissection	A separation of the layers within the wall of the descending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space.	UMLS:C4022878	hp.json	Type B aortic dissection	http://purl.obolibrary.org/obo/HP_0012499		
BFO:0000004	biolink:NamedThing	independent continuant	b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])		hp.json		http://purl.obolibrary.org/obo/BFO_0000004		
BFO:0000006	biolink:NamedThing	spatial region			hp.json		http://purl.obolibrary.org/obo/BFO_0000006		
HP:0012490	biolink:PhenotypicFeature	Panniculitis	Inflammation of adipose tissue.	UMLS:C0030326|MSH:D015434|SNOMEDCT_US:22125009	hp.json	Inflammation of adipose tissue|Inflammation of fat tissue	http://purl.obolibrary.org/obo/HP_0012490		
HP:0012491	biolink:PhenotypicFeature	Abnormal dense tubular system	An anomaly of the intracellular membrane complexes known as the dense tubular system.	UMLS:C4022881	hp.json		http://purl.obolibrary.org/obo/HP_0012491		
HP:0012492	biolink:PhenotypicFeature	Cerebral artery stenosis	Narrowing or constriction of the inner surface (lumen) of a cerebral artery.	UMLS:C1504438	hp.json	Narrowing of a cerebral artery	http://purl.obolibrary.org/obo/HP_0012492		
HP:0012493	biolink:PhenotypicFeature	Middle cerebral artery stenosis	Narrowing or constriction of the inner surface (lumen) of the middle cerebral artery.	UMLS:C1504568|SNOMEDCT_US:21290001000004104	hp.json		http://purl.obolibrary.org/obo/HP_0012493		
HP:0012494	biolink:PhenotypicFeature	Anterior cerebral artery stenosis	Narrowing or constriction of the inner surface (lumen) of the anterior cerebral artery.	UMLS:C1504567	hp.json		http://purl.obolibrary.org/obo/HP_0012494		
CHEBI:78631	biolink:ChemicalSubstance	chroman-6-ol	A chromanol that is chromane in which the hydrogen at position 6 is replaced by a hydroxy group.	Reaxys:1283166	hp.json	3,4-dihydrobenzopyran-6-ol|3,4-dihydro-2H-chromen-6-ol	http://purl.obolibrary.org/obo/CHEBI_78631		3_STAR
BFO:0000001	biolink:NamedThing	entity			hp.json		http://purl.obolibrary.org/obo/BFO_0000001		
BFO:0000002	biolink:NamedThing	continuant	An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts.		hp.json		http://purl.obolibrary.org/obo/BFO_0000002		
BFO:0000003	biolink:NamedThing	occurrent	An entity that has temporal parts and that happens, unfolds or develops through time.		hp.json		http://purl.obolibrary.org/obo/BFO_0000003		
HP:0012484	biolink:PhenotypicFeature	Abnormal dense granules	Defective structure, size or content of dense granules, platelet organelles that contain granules proaggregatory factors such as adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium, histamine and serotonin.	UMLS:C4022885	hp.json		http://purl.obolibrary.org/obo/HP_0012484		
HP:0012485	biolink:PhenotypicFeature	Abnormal surface-connected open canalicular system	An anomaly of the invaginations of the surface membrane that form the open canalicular system (OCS). The OCS serve as the pathway for transport of substances into the cells and as conduits for the discharge of alpha granule products secreted during the platelet release reaction.	UMLS:C4021840	hp.json		http://purl.obolibrary.org/obo/HP_0012485		
CL:0009084	biolink:Cell	epithelial cell of endometrial gland	An epithelial cell that is part of an endometrial gland.	EFO:0010710	hp.json	endometrial glandular epithelial cell	http://purl.obolibrary.org/obo/CL_0009084		location_grouping
HP:0012486	biolink:PhenotypicFeature	Myelitis	Inflammation of the spinal cord.	UMLS:C0026975|SNOMEDCT_US:41370002|MSH:D009187	hp.json	Inflammation of spinal cord	http://purl.obolibrary.org/obo/HP_0012486		
HP:0012487	biolink:PhenotypicFeature	Cerebellopontine angle arachnoid cyst	An arachnoid cyst located at the margin of the cerebellum and pons.	UMLS:C4022884	hp.json		http://purl.obolibrary.org/obo/HP_0012487		
HP:0012488	biolink:PhenotypicFeature	Intraventricular arachnoid cyst	An arachnoid cyst located within the ventricular system.	UMLS:C4022883	hp.json		http://purl.obolibrary.org/obo/HP_0012488		
HP:0012489	biolink:PhenotypicFeature	Suprasellar arachnoid cyst	An arachnoid cyst that progressively enlarges from an abnormality in the membrane of Liliequist or in the interpeduncular cistern, and typically, expands from the prepontine space, displacing the floor of the third ventricle upwards, the pituitary stalk and optic chiasm upwards and forwards, and the mammillary bodies upwards and backwards.	UMLS:C4022882	hp.json		http://purl.obolibrary.org/obo/HP_0012489		
HP:0012480	biolink:PhenotypicFeature	Abnormal cerebral vein morphology	An anomaly of cerebral veins.	UMLS:C4022888	hp.json	Abnormality of cerebral veins	http://purl.obolibrary.org/obo/HP_0012480		
HP:0012481	biolink:PhenotypicFeature	Cerebral venous angioma	A congenital malformation of veins which drain normal brain characterized by a caput medusae or an umbrellalike convergence of multiple venules on a single, or occasionally multiple, enlarged parenchymal or medullary vein, like the trunk of a tree or the shank of an umbrella. This dilated terminal vein penetrates the cortex to drain either (a) superficially to cortical veins or sinuses, (b) deeply to subependymal veins of the lateral ventricle and then into the galenic system, (c) to the fourth ventricle and then to the pontomesencephalic vein, or (d) to the precentral cerebellar vein and into the galenic system.	MSH:D020787|UMLS:C1956261	hp.json	Developmental Venous Anomaly	http://purl.obolibrary.org/obo/HP_0012481		
HP:0012482	biolink:PhenotypicFeature	Frontal venous angioma	A venous angioma of the frontal lobe of the brain.	UMLS:C4022887	hp.json		http://purl.obolibrary.org/obo/HP_0012482		
HP:0012483	biolink:PhenotypicFeature	Abnormal alpha granules	Defective structure, size or content of alpha granules, platelet organelles that contain several growth factors destined for release during platelet activation at sites of vessel wall injury.	UMLS:C4022886	hp.json		http://purl.obolibrary.org/obo/HP_0012483		
HP:0000495	biolink:PhenotypicFeature	Recurrent corneal erosions	The presence of recurrent corneal epithelial erosions. Although most corneal epithelial defects heal quickly, some may show recurrent ulcerations.	MSH:D003320|UMLS:C0010043|SNOMEDCT_US:91514001|UMLS:C4020888|UMLS:C0155119|SNOMEDCT_US:2055003	hp.json	Recurrent corneal ulceration|Corneal erosions, recurrent|Recurrent breakdown of clear protective layer of eye|Epithelial corneal erosions|Recurrent corneal ulcerations	http://purl.obolibrary.org/obo/HP_0000495		
HP:0000494	biolink:PhenotypicFeature	Downslanted palpebral fissures	The palpebral fissure inclination is more than two standard deviations below the mean.	UMLS:C0423110|SNOMEDCT_US:246800008	hp.json	Downward slanting palpebral fissures|Downslanting palpebral fissures|Antimongoloid slant of palpebral fissures|Downward slanted palpebral fissures|Downward slanting of the opening between the eyelids|Antimongoloid slanted palpebral fissures|Downslanting palpebral fissure|Down-slanting palpebral fissures|Down slanting palpebral fissures|Down-slanted palpebral fissures|Downward-slanting palpebral fissures|Antimongoloid eye slant|Down-slanting palpebral fissure|Palpebral fissures down-slanted	http://purl.obolibrary.org/obo/HP_0000494		hposlim_core
HP:0000497	biolink:PhenotypicFeature	Globe retraction and deviation on abduction		UMLS:C4025848	hp.json		http://purl.obolibrary.org/obo/HP_0000497		
HP:0000496	biolink:PhenotypicFeature	Abnormality of eye movement	An abnormality in voluntary or involuntary eye movements or their control.	UMLS:C0497202|SNOMEDCT_US:103252009	hp.json	Eye movement issue|Abnormal eye movement|Abnormal extraocular movement|Abnormal ocular movements|Abnormal movement of the globe of the eye|Eye movement abnormalities|Abnormal extraocular movements|Ocular movement abnormalities|Oculomotor abnormalities|Abnormality of eye movement|Abnormal eye movements|Abnormal motility of the globe of the eye|Abnormal eye motility	http://purl.obolibrary.org/obo/HP_0000496		hposlim_core
HP:0000499	biolink:PhenotypicFeature	Abnormal eyelash morphology	An abnormality of the eyelashes.	UMLS:C2675111	hp.json	Eyelash abnormality|Abnormal eyelashes|Abnormality of the eyelashes	http://purl.obolibrary.org/obo/HP_0000499		hposlim_core
HP:0000498	biolink:PhenotypicFeature	Blepharitis	Inflammation of the eyelids.	MSH:D001762|SNOMEDCT_US:41446000|UMLS:C0339063|SNOMEDCT_US:231796003|UMLS:C0005741	hp.json	Cellulitis of eyelids|Inflammation of eyelids	http://purl.obolibrary.org/obo/HP_0000498		hposlim_core
BFO:0000034	biolink:NamedThing	function			hp.json		http://purl.obolibrary.org/obo/BFO_0000034		
HP:0000491	biolink:PhenotypicFeature	Keratitis	Inflammation of the cornea.	MSH:D007634|SNOMEDCT_US:5888003|UMLS:C0022568	hp.json	Corneal inflammation	http://purl.obolibrary.org/obo/HP_0000491		hposlim_core
HP:0000490	biolink:PhenotypicFeature	Deeply set eye	An eye that is more deeply recessed into the plane of the face than is typical.	SNOMEDCT_US:80093006|SNOMEDCT_US:246923005|UMLS:C0423224|UMLS:C0014306|MSH:D015841	hp.json	Ocular depression|Sunken eyes|Deep-set eyes|Deep set eye|Enophthalmos|Deeply set eye|Sunken eye	http://purl.obolibrary.org/obo/HP_0000490		hposlim_core
BFO:0000030	biolink:NamedThing	object			hp.json		http://purl.obolibrary.org/obo/BFO_0000030		
HP:0000493	biolink:PhenotypicFeature	Abnormal foveal morphology	An abnormality of the fovea centralis, the central area of the macula that mediates central, high resolution vision and contains the largest concentration of cone cells in the retina.	UMLS:C4025849	hp.json	Abnormality of the fovea	http://purl.obolibrary.org/obo/HP_0000493		
HP:0000492	biolink:PhenotypicFeature	Abnormal eyelid morphology	An abnormality of the eyelids.	UMLS:C4021803	hp.json	Abnormality of the eyelid|Abnormality of the eyelids	http://purl.obolibrary.org/obo/HP_0000492		hposlim_core
HP:0012473	biolink:PhenotypicFeature	Tongue atrophy	Wasting of the tongue.	UMLS:C0241423|SNOMEDCT_US:249382006|SNOMEDCT_US:50805004|UMLS:C0426494	hp.json	Atrophy of the tongue|Lingual wasting|Wasting of the tongue|Lingual atrophy	http://purl.obolibrary.org/obo/HP_0012473		
HP:0012474	biolink:PhenotypicFeature	Carotid artery occlusion	Complete obstruction of a carotid artery.	SNOMEDCT_US:69798007|UMLS:C0265101|SNOMEDCT_US:266254007	hp.json	Obstructed carotid artery	http://purl.obolibrary.org/obo/HP_0012474		
CL:0009095	biolink:Cell	endothelial cell of uterus	An endothelial cell that is part of a uterus.	EFO:0010711	hp.json	uterine endothelial cell	http://purl.obolibrary.org/obo/CL_0009095		location_grouping
HP:0012475	biolink:PhenotypicFeature	Decreased circulating level of specific antibody	The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against a specific antigen or microorganism.	UMLS:C0398711|SNOMEDCT_US:234556002	hp.json	Abnormal specific antibody response|Decreased specific antibody in blood|Specific antibody deficiency	http://purl.obolibrary.org/obo/HP_0012475		
HP:0012476	biolink:PhenotypicFeature	Decreased specific pneumococcal antibody level	The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against pneumococci.	UMLS:C4022890	hp.json	Low pneumococcal antibody titer|Specific pneumococcal antibody deficiency	http://purl.obolibrary.org/obo/HP_0012476		
HP:0012477	biolink:PhenotypicFeature	Vocal tremor	A wavering, unsteady voice that reflects involuntary and approximately sinusoidal oscillation of motor unit firings of laryngeal muscles. Vocal tremor results in low frequency modulations of voice frequency or amplitude and intermittent voice instability.	UMLS:C4022889	hp.json	Shakey voice|Vocal tremor	http://purl.obolibrary.org/obo/HP_0012477		
HP:0012478	biolink:PhenotypicFeature	Temporomandibular joint ankylosis	Bony fusion of the mandibular condyle to the base of the skull, resulting in limitation of jaw opening.	UMLS:C0685924|SNOMEDCT_US:50603008|SNOMEDCT_US:298231004|MSH:C536957|SNOMEDCT_US:91866004|UMLS:C2931375|UMLS:C0575010	hp.json	Ankylosis of temporomandibular joint|Adhesion of the temporomandibular joint|Rigidity of the temporomandibular joint|Freezing of the temporomandibular joint|Temporomandibular joint fusion|Freezing of jaw joint	http://purl.obolibrary.org/obo/HP_0012478		
CL:0009092	biolink:Cell	endothelial cell of placenta	An endothelial cell that is part of a placenta.	EFO:0010708	hp.json	placental endothelial cell	http://purl.obolibrary.org/obo/CL_0009092		location_grouping
HP:0012479	biolink:PhenotypicFeature	Temporomandibular joint crepitus	Noises from the temporomandibular joint during mandibular movement (e.g., chewing). Temporomandibular joint crepitus is often described as a clicking, popping, grating sound.	SNOMEDCT_US:298377005|UMLS:C4280315|UMLS:C4280314|UMLS:C4280313|UMLS:C0575154	hp.json	Jaw joint noise|Temporomandibular joint grating sound|Temporomandibular joint popping sound|Jaw joint clicking sound|Temporomandibular joint clicking sound|Jaw joint grating sound|Jaw joint popping sound|Jaw joint sounds|Temporomandibular joint sounds|Temporomandibular joint noise|Jaw joint crepitus	http://purl.obolibrary.org/obo/HP_0012479		
UBERON:5002544	biolink:AnatomicalEntity	digit plus metapodial segment	A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	digit|digit digitopodial subdivision|digit ( phalanges plus metapodial) plus soft tissue|digit ray	http://purl.obolibrary.org/obo/UBERON_5002544		
CL:0009093	biolink:Cell	smooth muscle cell of placenta	A smooth muscle cell that is part of a placenta.	EFO:0010709	hp.json	placental smooth muscle cell	http://purl.obolibrary.org/obo/CL_0009093		location_grouping
HP:0012470	biolink:PhenotypicFeature	Setting-sun eye phenomenon	An ophthalmologic sign in young children resulting from upward-gaze paresis. In this condition, the eyes appear driven downward, the sclera may be seen between the upper eyelid and the iris, and part of the lower pupil may be covered by the lower eyelid.	UMLS:C0423128|UMLS:C4020721|SNOMEDCT_US:63342001	hp.json	Setting-sun eye phenomenon|Sun setting eyes|Sunsetting eye|Eyes fixed downward	http://purl.obolibrary.org/obo/HP_0012470		
HP:0012471	biolink:PhenotypicFeature	Thick vermilion border	Increased width of the skin of vermilion border region of upper lip.	UMLS:C1836543	hp.json	Prominent lips|Plump lips|Increased volume of lip|Thick lips|Full lips|Increased volume of lip vermillion	http://purl.obolibrary.org/obo/HP_0012471		
HP:0012472	biolink:PhenotypicFeature	Eclabion	A turning outward of the lip or lips, that is, eversion of the lips.	UMLS:C3550430	hp.json	Outward turned lips|Everted lips|Eclabium	http://purl.obolibrary.org/obo/HP_0012472		
BFO:0000023	biolink:NamedThing	role	A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts.		hp.json		http://purl.obolibrary.org/obo/BFO_0000023		
BFO:0000020	biolink:NamedThing	specifically dependent continuant	A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.		hp.json		http://purl.obolibrary.org/obo/BFO_0000020		
HP:0100488	biolink:PhenotypicFeature	Synostosis of the proximal phalanx of the hallux with the 1st metatarsal		UMLS:C4022043	hp.json	Fusion of the innermost big toe bone with the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0100488		
HP:0100489	biolink:PhenotypicFeature	Proximal/middle symphalangism of 2nd toe	Bony fusion of the middle and proximal phalanges of the 2nd toe.	UMLS:C4020972	hp.json	Symphalangism of the middle and proximal phalanges of the 2nd toe|Fused middle and innermost bones of 2nd toe	http://purl.obolibrary.org/obo/HP_0100489		
GO:0032438	biolink:BiologicalProcess	melanosome organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.		hp.json	melanosome organisation|melanosome organization and biogenesis	http://purl.obolibrary.org/obo/GO_0032438		
HP:0100486	biolink:PhenotypicFeature	Symphalangism of the proximal phalanx of the 5th toe with the 5th metatarsal		UMLS:C4022045	hp.json	Fused innermost pinky toe bone with the 5th long bone of foot	http://purl.obolibrary.org/obo/HP_0100486		
HP:0100487	biolink:PhenotypicFeature	Triangular shaped distal phalanx of the 5th toe		UMLS:C4022044	hp.json	Triangular shaped outermost bone of the pinky toe|Triangular shaped outermost bone of the little toe|Triangular shaped outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100487		
HP:0100484	biolink:PhenotypicFeature	Symphalangism of the proximal phalanx of the 3rd toe with the 3rd metatarsal		UMLS:C4022047	hp.json	Fused innermost bones of third toe with 3rd long bone of foot	http://purl.obolibrary.org/obo/HP_0100484		
HP:0100485	biolink:PhenotypicFeature	Symphalangism of the proximal phalanx of the 4th toe with the 4th metatarsal		UMLS:C4022046	hp.json	Fused innermost bone of the 4th toe with 4th long bone of foot	http://purl.obolibrary.org/obo/HP_0100485		
HP:0100482	biolink:PhenotypicFeature	Proximal/middle symphalangism of 5th toe	Bony fusion of the middle and proximal phalanges of the 5th toe.	UMLS:C4020973	hp.json	Symphalangism of the middle and proximal phalanges of the 5th toe|Fused innermost and middle pinkie toe bones|Fused innermost and middle pinky toe bones|Fused innermost and middle little toe bones	http://purl.obolibrary.org/obo/HP_0100482		
HP:0100483	biolink:PhenotypicFeature	Symphalangism of the proximal phalanx of the 2nd toe with the 2nd metatarsal		UMLS:C4022048	hp.json	Fused innermost bone of 2nd toe with the 2nd long bone of foot	http://purl.obolibrary.org/obo/HP_0100483		
HP:0100480	biolink:PhenotypicFeature	Proximal/middle symphalangism of 3rd toe	Bony fusion of the middle and proximal phalanges of the 3rd toe.	UMLS:C4020975	hp.json	Fused innermost and middle bones of 3rd toe|Symphalangism of the middle and proximal phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100480		
HP:0100481	biolink:PhenotypicFeature	Proximal/middle symphalangism of 4th toe	Bony fusion of the middle and proximal phalanges of the 4th toe.	UMLS:C4020974	hp.json	Symphalangism of the middle and proximal phalanges of the 4th toe|Fused innermost and middle bones of 4th toe	http://purl.obolibrary.org/obo/HP_0100481		
GO:0032432	biolink:NamedThing	actin filament bundle			hp.json		http://purl.obolibrary.org/obo/GO_0032432		
HP:0100499	biolink:PhenotypicFeature	Tibial deviation of toes		UMLS:C3806533	hp.json	Medial deviation of toes	http://purl.obolibrary.org/obo/HP_0100499		
HP:0100497	biolink:PhenotypicFeature	Vitamin B3 deficiency		SNOMEDCT_US:418279001|UMLS:C0030783|MSH:D010383|SNOMEDCT_US:418186002	hp.json	Vitamin B3 deficiency	http://purl.obolibrary.org/obo/HP_0100497		
HP:0100498	biolink:PhenotypicFeature	Deviation of toes		UMLS:C4022039	hp.json		http://purl.obolibrary.org/obo/HP_0100498		
HP:0100495	biolink:PhenotypicFeature	Mastocytosis	The presence of an increased number of mast cells and CD34+ mast cell precursors in the body.	SNOMEDCT_US:125541005|UMLS:C0024899|MSH:D008415|SNOMEDCT_US:397007003	hp.json		http://purl.obolibrary.org/obo/HP_0100495		
HP:0100496	biolink:PhenotypicFeature	Abnormality of the vitamin B3 metabolism		UMLS:C4022040	hp.json	Abnormality of the vitamin B3 metabolism	http://purl.obolibrary.org/obo/HP_0100496		
HP:0100493	biolink:PhenotypicFeature	Hypoammonemia	A decreased concentration of ammonia in the blood.	UMLS:C4022041	hp.json		http://purl.obolibrary.org/obo/HP_0100493		
HP:0100494	biolink:PhenotypicFeature	Abnormal mast cell morphology	Any structural anomaly of mast cells, which are found in almost all tissues and contain numerous basophilic granules and are capable of releasing large amounts of histamine and heparin upon activation.	SNOMEDCT_US:397017008|UMLS:C1301149	hp.json	Abnormality of mastocytes|Abnormality of mast cells	http://purl.obolibrary.org/obo/HP_0100494		
CHEBI:140785	biolink:ChemicalSubstance	R-cob(III)alamin		MetaCyc:CPD-20938	hp.json	an R-cob(III)alamin	http://purl.obolibrary.org/obo/CHEBI_140785		2_STAR
HP:0100491	biolink:PhenotypicFeature	Abnormality of lower limb joint		UMLS:C4020971	hp.json	Abnormality of lower limb joint|Abnormality of the joints of the lower limbs	http://purl.obolibrary.org/obo/HP_0100491		
HP:0100492	biolink:PhenotypicFeature	obsolete Joint contractures involving the joints of the feet			hp.json		http://purl.obolibrary.org/obo/HP_0100492		
HP:0100490	biolink:PhenotypicFeature	Camptodactyly of finger	The distal interphalangeal joint and/or the proximal interphalangeal joint of the fingers cannot be extended to 180 degrees by either active or passive extension.	SNOMEDCT_US:202281000|UMLS:C0409348	hp.json	Camptodactyly of hands|Camptodactyly of proximal interphalangeal joint|Contractures of the proximal interphalangeal joints of the fingers|Permanent flexion of the finger|Proximal interphalangeal finger joint contractures|Flexion contractures of proximal interphalangeal joints	http://purl.obolibrary.org/obo/HP_0100490		
GO:0007492	biolink:BiologicalProcess	endoderm development	The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.		hp.json		http://purl.obolibrary.org/obo/GO_0007492		
GO:0032418	biolink:BiologicalProcess	lysosome localization	Any process in which a lysosome is transported to, and/or maintained in, a specific location.		hp.json	lysosome localisation	http://purl.obolibrary.org/obo/GO_0032418		
GO:0019438	biolink:BiologicalProcess	aromatic compound biosynthetic process	The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring.		hp.json	aromatic compound formation|aromatic compound biosynthesis|aromatic hydrocarbon biosynthesis|aromatic hydrocarbon biosynthetic process|aromatic compound anabolism|aromatic compound synthesis	http://purl.obolibrary.org/obo/GO_0019438		
GO:0032402	biolink:BiologicalProcess	melanosome transport	The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0032402		
PATO:0002212	biolink:NamedThing	slender	A shape quality inhering in a bearer by virtue of the bearer's being small or narrow in circumference or width in proportion to length or height.		hp.json	gracile	http://purl.obolibrary.org/obo/PATO_0002212		value_slim
GO:0044458	biolink:BiologicalProcess	motile cilium assembly	The aggregation, arrangement and bonding together of a set of components to form a motile cilium.		hp.json	motile primary cilia formation|nodal cilium formation|motile primary cilium assembly|motile primary cilium formation|nodal cilium assembly|motile primary cilia assembly	http://purl.obolibrary.org/obo/GO_0044458		
GO:0032401	biolink:BiologicalProcess	establishment of melanosome localization	The directed movement of a melanosome to a specific location.		hp.json	establishment of melanosome localisation	http://purl.obolibrary.org/obo/GO_0032401		
GO:0032400	biolink:BiologicalProcess	melanosome localization	Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell.		hp.json	melanosome localisation	http://purl.obolibrary.org/obo/GO_0032400		
GO:0007439	biolink:BiologicalProcess	ectodermal digestive tract development	The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm.		hp.json	ectodermal gut development	http://purl.obolibrary.org/obo/GO_0007439		
GO:0007442	biolink:BiologicalProcess	hindgut morphogenesis	The process in which the anatomical structures of the hindgut are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0007442		
GO:0007440	biolink:BiologicalProcess	foregut morphogenesis	The process in which the anatomical structures of the foregut are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0007440		
GO:0007417	biolink:BiologicalProcess	central nervous system development	The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.	Wikipedia:Neural_development	hp.json	CNS development	http://purl.obolibrary.org/obo/GO_0007417		
GO:0007416	biolink:BiologicalProcess	synapse assembly	The aggregation, arrangement and bonding together of a set of components to form a synapse.  This process ends when the synapse is mature (functional).	Wikipedia:Synaptogenesis	hp.json	synapse biogenesis|synaptogenesis	http://purl.obolibrary.org/obo/GO_0007416		goslim_synapse
GO:0007423	biolink:BiologicalProcess	sensory organ development	The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.		hp.json	sense organ development	http://purl.obolibrary.org/obo/GO_0007423		goslim_drosophila
GO:0007422	biolink:BiologicalProcess	peripheral nervous system development	The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.		hp.json		http://purl.obolibrary.org/obo/GO_0007422		
GO:0007420	biolink:BiologicalProcess	brain development	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).		hp.json		http://purl.obolibrary.org/obo/GO_0007420		
HP:0100402	biolink:PhenotypicFeature	Duplication of the middle phalanx of the 4th toe	Partial or complete duplication of middle phalanx of fourth toe.	UMLS:C4020995	hp.json	Partial/complete duplication of the middle phalanx of the 4th toe|Duplication of the middle phalanx of the fourth toe|Duplication of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100402		
HP:0100403	biolink:PhenotypicFeature	Duplication of the middle phalanx of the 5th toe	Partial or complete duplication of the middle phalanx of the 5th toe.	UMLS:C4020994	hp.json	Partial/complete duplication of the middle phalanx of the 5th toe|Duplication of the middle bone of the little toe|Duplication of the middle bone of the pinkie toe|Duplication of the middle bone of the pinky toe|Duplication of the middle phalanx of the fifth toe	http://purl.obolibrary.org/obo/HP_0100403		
HP:0100400	biolink:PhenotypicFeature	Duplication of the distal phalanx of the 5th toe	Partial or complete duplication of the distal phalanx of little toe.	UMLS:C4020997	hp.json	Duplication of the outermost bone of the pinky toe|Duplication of the outermost bone of the little toe|Duplication of the distal phalanx of the fifth toe|Duplication of the outermost bone of the pinkie toe|Duplication of the outermost bone of the fifth toe|Partial/complete duplication of the distal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100400		
HP:0100401	biolink:PhenotypicFeature	Duplication of the middle phalanx of the 3rd toe	Partial or complete duplication of middle phalanx of third toe.	UMLS:C4020996	hp.json	Partial/complete duplication of the middle phalanx of the 3rd toe|Duplication of the middle bone of the 3rd toe|Duplication of the middle phalanx of the third toe	http://purl.obolibrary.org/obo/HP_0100401		
CHEBI:67011	biolink:ChemicalSubstance	folates	An N-acyl-L-alpha-amino acid anion obtained by deprotonation of any folic acid.		hp.json	folate|folate anion|folate anions	http://purl.obolibrary.org/obo/CHEBI_67011		3_STAR
CHEBI:67016	biolink:ChemicalSubstance	tetrahydrofolate	A folate obtained by deprotonation of any tetrahydrofolic acid.		hp.json	tetrahydrofolates|tetrahydrofolate anions|tetrahydrofolate anion	http://purl.obolibrary.org/obo/CHEBI_67016		3_STAR
CHEBI:67013	biolink:ChemicalSubstance	methyl-branched fatty acid anion	Any branched-chain fatty acid anion containing methyl branches only.		hp.json	methyl-branched fatty acid anions	http://purl.obolibrary.org/obo/CHEBI_67013		3_STAR
HP:0100408	biolink:PhenotypicFeature	Complete duplication of the distal phalanx of the 4th toe	Complete duplication of the distal phalanx of fourth toe.	UMLS:C4020989	hp.json	Complete duplication of the distal phalanx of the fourth toe|Complete duplication of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100408		
HP:0100409	biolink:PhenotypicFeature	Complete duplication of the distal phalanx of the 5th toe	Complete duplication of the distal phalanx of little toe.	UMLS:C4020988	hp.json	Complete duplication of the outermost bone of the little toe|Complete duplication of the outermost bone of the pinkie toe|Complete duplication of the distal phalanx of the fifth toe|Complete duplication of the outermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100409		
HP:0100406	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the 5th toe	Partial or complete duplication of the proximal phalanx of fifth toe.	UMLS:C4020991	hp.json	Duplication of the innermost bone of the little toe|Duplication of the proximal phalanx of the fifth toe|Duplication of the innermost bone of the pinkie toe|Duplication of the innermost bone of the pinky toe|Partial/complete duplication of the proximal phalanx of the 5th toe	http://purl.obolibrary.org/obo/HP_0100406		
HP:0100407	biolink:PhenotypicFeature	Complete duplication of the distal phalanx of the 3rd toe	Complete duplication of distal phalanx of third toe.	UMLS:C4020990	hp.json	Complete duplication of the distal phalanx of the third toe|Complete duplication of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100407		
HP:0100404	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the 3rd toe	Partial or complete duplication of proximal phalanx of third toe.	UMLS:C4020993	hp.json	Duplication of the proximal phalanx of the third toe|Duplication of the innermost 3rd toe bone|Partial/complete duplication of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100404		
HP:0100405	biolink:PhenotypicFeature	Duplication of the proximal phalanx of the 4th toe	Partial or complete duplication of the proximal phalanx of fourth toe.	UMLS:C4020992	hp.json	Duplication of the proximal phalanx of the fourth toe|Partial/complete duplication of the proximal phalanx of the 4th toe|Duplication of the innermost 4th toe bone	http://purl.obolibrary.org/obo/HP_0100405		
HP:0100413	biolink:PhenotypicFeature	Complete duplication of the proximal phalanx of the 3rd toe	Complete duplication of proximal phalanx of third toe.	UMLS:C4022105	hp.json	Complete duplication of the innermost 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100413		
HP:0100414	biolink:PhenotypicFeature	Complete duplication of the proximal phalanx of the 4th toe		UMLS:C4022104	hp.json	Complete duplication of the innermost 4th toe bone	http://purl.obolibrary.org/obo/HP_0100414		
HP:0100411	biolink:PhenotypicFeature	Complete duplication of the middle phalanx of the 4th toe	Complete duplication of middle phalanx of fourth toe.	UMLS:C4020986	hp.json	Complete duplication of the middle phalanx of the fourth toe|Complete duplication of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100411		
HP:0100412	biolink:PhenotypicFeature	Complete duplication of the middle phalanx of the 5th toe	Complete duplication of the middle phalanx of the 5th toe.	UMLS:C4020985	hp.json	Complete duplication of the middle bone of the little toe|Complete duplication of the middle bone of the pinky toe|Complete duplication of the middle bone of the pinkie toe|Complete duplication of the middle phalanx of the fifth toe	http://purl.obolibrary.org/obo/HP_0100412		
HP:0100410	biolink:PhenotypicFeature	Complete duplication of the middle phalanx of the 3rd toe	Complete duplication of middle phalanx of third toe.	UMLS:C4020987	hp.json	Complete duplication of the middle bone of the 3rd toe|Complete duplication of the middle phalanx of the third toe	http://purl.obolibrary.org/obo/HP_0100410		
HP:0100419	biolink:PhenotypicFeature	Partial duplication of the middle phalanx of the 3rd toe	Partial duplication of middle phalanx of third toe.	UMLS:C4020980	hp.json	Partial duplication of the middle bone of 3rd toe|Partial duplication of the middle phalanx of the third toe	http://purl.obolibrary.org/obo/HP_0100419		
HP:0100417	biolink:PhenotypicFeature	Partial duplication of the distal phalanx of the 4th toe	Partial duplication of the distal phalanx of fourth toe.	UMLS:C4020982	hp.json	Partial duplication of the outermost bone of the fourth toe|Partial duplication of the distal phalanx of the fourth toe	http://purl.obolibrary.org/obo/HP_0100417		
HP:0100418	biolink:PhenotypicFeature	Partial duplication of the distal phalanx of the 5th toe	Partial duplication of the distal phalanx of little toe.	UMLS:C4020981	hp.json	Partial duplication of the outermost bone of the pinky toe|Partial duplication of the outermost bone of the little toe|Partial duplication of the outermost bone of the pinkie toe|Partial duplication of the distal phalanx of the fifth toe|Partial duplication of the outermost bone of the fifth toe	http://purl.obolibrary.org/obo/HP_0100418		
HP:0100415	biolink:PhenotypicFeature	Complete duplication of the proximal phalanx of the 5th toe	Complete duplication of the proximal phalanx of fifth toe.	UMLS:C4020984	hp.json	Complete duplication of the innermost bone of the little toe|Complete duplication of the innermost bone of the pinkie toe|Complete duplication of the proximal phalanx of the fifth toe|Complete duplication of the innermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100415		
HP:0100416	biolink:PhenotypicFeature	Partial duplication of the distal phalanx of the 3rd toe	Partial duplication of distal phalanx of third toe.	UMLS:C4020983	hp.json	Partial duplication of the distal phalanx of the third toe|Partial duplication of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100416		
HP:0100424	biolink:PhenotypicFeature	Partial duplication of the proximal phalanx of the 5th toe	Partial duplication of the proximal phalanx of fifth toe.	UMLS:C4020976	hp.json	Partial duplication of the proximal phalanx of the fifth toe|Partial duplication of the innermost bone of the pinkie toe|Partial duplication of the innermost bone of the pinky toe|Partial duplication of the innermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100424		
HP:0100425	biolink:PhenotypicFeature	Broad middle phalanx of the 3rd toe		UMLS:C4022102	hp.json	Broad middle 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100425		
HP:0100422	biolink:PhenotypicFeature	Partial duplication of the proximal phalanx of the 3rd toe	Partial duplication of proximal phalanx of third toe.	UMLS:C4020977	hp.json	Partial duplication of the innermost bone of 3rd toe|Partial duplication of the proximal phalanx of the third toe	http://purl.obolibrary.org/obo/HP_0100422		
HP:0100423	biolink:PhenotypicFeature	Partial duplication of the proximal phalanx of the 4th toe		UMLS:C4022103	hp.json	Partial duplication of the innermost bone of 4th toe	http://purl.obolibrary.org/obo/HP_0100423		
HP:0100420	biolink:PhenotypicFeature	Partial duplication of the middle phalanx of the 4th toe	Partial duplication of middle phalanx of fourth toe.	UMLS:C4020979	hp.json	Partial duplication of the middle bone of the 4th toe|Partial duplication of the middle phalanx of the fourth toe	http://purl.obolibrary.org/obo/HP_0100420		
HP:0100421	biolink:PhenotypicFeature	Partial duplication of the middle phalanx of the 5th toe	Partial duplication of the middle phalanx of the 5th toe.	UMLS:C4020978	hp.json	Partial duplication of the middle bone of the little toe|Partial duplication of the middle bone of the pinky toe|Partial duplication of the middle bone of the pinkie toe|Partial duplication of the middle phalanx of the fifth toe	http://purl.obolibrary.org/obo/HP_0100421		
CHEBI:82663	biolink:ChemicalSubstance	elemental iron	An elemental molecular entity in which all of the atoms have atomic number 26.		hp.json		http://purl.obolibrary.org/obo/CHEBI_82663		3_STAR
HP:0100428	biolink:PhenotypicFeature	Broad proximal phalanx of the 3rd toe		UMLS:C4022099	hp.json	Wide innermost bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0100428		
HP:0100429	biolink:PhenotypicFeature	Broad proximal phalanx of the 4th toe		UMLS:C4022098	hp.json	Wide innermost bone of 4th toe	http://purl.obolibrary.org/obo/HP_0100429		
HP:0100426	biolink:PhenotypicFeature	Broad middle phalanx of the 4th toe		UMLS:C4022101	hp.json	Broad middle 4th toe bone	http://purl.obolibrary.org/obo/HP_0100426		
HP:0100427	biolink:PhenotypicFeature	Broad middle phalanx of the 5th toe		UMLS:C4022100	hp.json	Broad middle bone of the pinkie toe|Broad middle bone of the pinky toe|Broad middle bone of the little toe	http://purl.obolibrary.org/obo/HP_0100427		
HP:0100435	biolink:PhenotypicFeature	Bullet-shaped middle phalanx of the 4th toe	An abnormal morphology of the middle phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4022092	hp.json	Bullet-shaped middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100435		
HP:0100436	biolink:PhenotypicFeature	Bullet-shaped middle phalanx of the 5th toe	An abnormal morphology of the middle phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4022091	hp.json	Bullet-shaped middle bone of the little toe|Bullet-shaped middle bone of the pinkie toe|Bullet-shaped middle bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100436		
HP:0100433	biolink:PhenotypicFeature	Broad distal phalanx of the 5th toe		UMLS:C4022094	hp.json	Wide outermost bone of the pinky toe|Wide outermost bone of the little toe|Broad outermost bone of the 5th toe|Wide outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100433		
HP:0100434	biolink:PhenotypicFeature	Bullet-shaped middle phalanx of the 3rd toe	An abnormal morphology of the middle phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4022093	hp.json	Bullet-shaped middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100434		
HP:0100431	biolink:PhenotypicFeature	Broad distal phalanx of the 3rd toe		UMLS:C4022096	hp.json	Broad outermost bone of the 3rd toe|Wide outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100431		
HP:0100432	biolink:PhenotypicFeature	Broad distal phalanx of the 4th toe		UMLS:C4022095	hp.json	Wide outermost bone of the 4th toe|Broad outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100432		
HP:0100430	biolink:PhenotypicFeature	Broad proximal phalanx of the 5th toe		UMLS:C4022097	hp.json	Broad innermost bone of the little toe|Broad innermost bone of the pinkie toe|Broad innermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100430		
PR:000008730	biolink:Protein	4-hydroxyphenylpyruvate dioxygenase	A protein that is a translation product of the human HPD gene or a 1:1 ortholog thereof.	IUPHARobj:2621	hp.json	HPPDase|F Alloantigen|4-hydroxyphenylpyruvic acid oxidase|4HPPD|HPD|PPD|F protein	http://purl.obolibrary.org/obo/PR_000008730		
CHEBI:79020	biolink:ChemicalSubstance	alpha,beta-unsaturated monocarboxylic acid	A monocarboxylic acid in which the carbon of the carboxy group is directly attached to a C=C or C#C bond.		hp.json	2,3-unsaturated monocarboxylic acid|2,3-unsaturated monocarboxylic acids|alpha,beta-unsaturated monocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_79020		3_STAR
CHEBI:79026	biolink:ChemicalSubstance	molybdenum cofactor(3-)	An organic anionic group derived from molybdenum cofactor(3-).  It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).		hp.json	molybdenum cofactor	http://purl.obolibrary.org/obo/CHEBI_79026		3_STAR
HP:0100439	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the 5th toe	An abnormal morphology of the proximal phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4022088	hp.json	Bullet-shaped innermost bone of pinky toe|Bullet-shaped innermost bone of little toe|Bullet-shaped innermost bone of pinkie toe	http://purl.obolibrary.org/obo/HP_0100439		
HP:0100437	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the 3rd toe	An abnormal morphology of the proximal phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4022090	hp.json	Bullet-shaped proximal bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100437		
HP:0100438	biolink:PhenotypicFeature	Bullet-shaped proximal phalanx of the 4th toe	An abnormal morphology of the proximal phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4022089	hp.json	Bullet-shaped proximal bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100438		
HP:0100446	biolink:PhenotypicFeature	Curved proximal phalanx of the 3rd toe	A deviation from the normal straight form of the proximal phalanx of the third toe.	UMLS:C4022081	hp.json	Curved innermost bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0100446		
HP:0100447	biolink:PhenotypicFeature	Curved proximal phalanx of the 4th toe	A deviation from the normal straight form of the proximal phalanx of the fourth toe.	UMLS:C4022080	hp.json	Curved innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100447		
HP:0100444	biolink:PhenotypicFeature	Curved middle phalanx of the 4th toe	A deviation from the normal straight form of the middle phalanx of the fourth toe.	UMLS:C4022083	hp.json	Curved middle bone of 4th toe	http://purl.obolibrary.org/obo/HP_0100444		
HP:0100445	biolink:PhenotypicFeature	Curved middle phalanx of the 5th toe	A deviation from the normal straight form of the middle phalanx of the fifth toe.	UMLS:C4022082	hp.json	Curved middle bone of pinky toe|Curved middle bone of little toe|Curved middle bone of pinkie toe	http://purl.obolibrary.org/obo/HP_0100445		
HP:0100442	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the 5th toe	An abnormal morphology of the distal phalanx of the fifth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4022085	hp.json	Bullet-shaped outermost bone of the little toe|Bullet-shaped outermost bone of the pinky toe|Bullet-shaped outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100442		
HP:0100443	biolink:PhenotypicFeature	Curved middle phalanx of the 3rd toe	A deviation from the normal straight form of the middle phalanx of the third toe.	UMLS:C4022084	hp.json	Curved middle bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0100443		
HP:0100440	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the 3rd toe	An abnormal morphology of the distal phalanx of the third toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4022087	hp.json	Bullet-shaped outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100440		
HP:0100441	biolink:PhenotypicFeature	Bullet-shaped distal phalanx of the 4th toe	An abnormal morphology of the distal phalanx of the fourth toe, with a short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.	UMLS:C4022086	hp.json	Bullet-shaped outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100441		
HP:0100448	biolink:PhenotypicFeature	Curved proximal phalanx of the 5th toe	A deviation from the normal straight form of the proximal phalanx of the fifth toe.	UMLS:C4022079	hp.json	Curved innermost little toe bone|Curved innermost pinky toe bone|Curved innermost pinkie toe bone	http://purl.obolibrary.org/obo/HP_0100448		
HP:0100449	biolink:PhenotypicFeature	Curved distal phalanx of the 3rd toe	A deviation from the normal straight form of the distal phalanx of the third toe.	UMLS:C4022078	hp.json	Curved outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100449		
HP:0100457	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanx of the 5th toe		UMLS:C4022070	hp.json		http://purl.obolibrary.org/obo/HP_0100457		
HP:0100458	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanx of the 3rd toe		UMLS:C4022069	hp.json	Osteolytic defects of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100458		
HP:0100455	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanx of the 3rd toe		UMLS:C4022072	hp.json		http://purl.obolibrary.org/obo/HP_0100455		
HP:0100456	biolink:PhenotypicFeature	Osteolytic defects of the proximal phalanx of the 4th toe		UMLS:C4022071	hp.json		http://purl.obolibrary.org/obo/HP_0100456		
HP:0100453	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanx of the 4th toe		UMLS:C4022074	hp.json		http://purl.obolibrary.org/obo/HP_0100453		
HP:0100454	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanx of the 5th toe		UMLS:C4022073	hp.json		http://purl.obolibrary.org/obo/HP_0100454		
HP:0100451	biolink:PhenotypicFeature	Curved distal phalanx of the 5th toe	A deviation from the normal straight form of the distal phalanx of the fifth toe.	UMLS:C4022076	hp.json	Curved outermost bone of the little toe|Curved outermost bone of the pinkie toe|Curved outermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100451		
HP:0100452	biolink:PhenotypicFeature	Osteolytic defects of the middle phalanx of the 3rd toe		UMLS:C4022075	hp.json		http://purl.obolibrary.org/obo/HP_0100452		
HP:0100450	biolink:PhenotypicFeature	Curved distal phalanx of the 4th toe	A deviation from the normal straight form of the distal phalanx of the fourth toe.	UMLS:C4022077	hp.json	Curved outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100450		
HP:0100459	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanx of the 4th toe		UMLS:C4022068	hp.json	Osteolytic defects of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100459		
HP:0100468	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the 4th toe	Uneven increase in bone density of the distal phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4022059	hp.json	Uneven increase in bone density in the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100468		
HP:0100469	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the 5th toe	Patchy (irregular) increase in bone density of the distal phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4022058	hp.json	Uneven increase in bone density in the outermost pinky toe bone|Uneven increase in bone density in the outermost pinkie toe bone|Uneven increase in bone density in the outermost little toe bone	http://purl.obolibrary.org/obo/HP_0100469		
HP:0100466	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the 5th toe	Uneven increase in bone density of the proximal phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4022061	hp.json	Uneven increase in bone density in the innermost bone of the pinkie toe|Uneven increase in bone density in the innermost bone of the pinky toe|Uneven increase in bone density in the innermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100466		
HP:0100467	biolink:PhenotypicFeature	Patchy sclerosis of the distal phalanx of the 3rd toe		UMLS:C4022060	hp.json	Uneven increase in bone density in the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100467		
HP:0100464	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the 3rd toe		UMLS:C4022063	hp.json	Uneven increase in bone density in the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100464		
HP:0100465	biolink:PhenotypicFeature	Patchy sclerosis of the proximal phalanx of the 4th toe	Uneven increase in bone density of the proximal phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4022062	hp.json	Uneven increase in bone density in the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100465		
HP:0100462	biolink:PhenotypicFeature	Patchy sclerosis of the middle phalanx of the 4th toe	Uneven increase in bone density of the middle phalanx of the fourth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4022065	hp.json	Uneven increase in bone density in middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100462		
HP:0100463	biolink:PhenotypicFeature	Patchy sclerosis of the middle phalanx of the 5th toe	Uneven increase in bone density of the middle phalanx of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.	UMLS:C4022064	hp.json	Uneven increase in bone density in the middle bone of the little toe|Uneven increase in bone density in the middle bone of the pinky toe|Uneven increase in bone density in the middle bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100463		
HP:0100460	biolink:PhenotypicFeature	Osteolytic defects of the distal phalanx of the 5th toe		UMLS:C4022067	hp.json	Osteolytic defects of the outermost bone of the 5th toe	http://purl.obolibrary.org/obo/HP_0100460		
HP:0100461	biolink:PhenotypicFeature	Patchy sclerosis of the middle phalanx of the 3rd toe		UMLS:C4022066	hp.json	Uneven increase in bone density in the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100461		
GO:0007498	biolink:BiologicalProcess	mesoderm development	The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0007498		goslim_drosophila
CHEBI:67079	biolink:ChemicalSubstance	anti-inflammatory agent	Any compound that has anti-inflammatory effects.		hp.json	anti-inflammatory agents|antiinflammatory agent|antiinflammatory agents	http://purl.obolibrary.org/obo/CHEBI_67079		3_STAR
GO:0007494	biolink:BiologicalProcess	midgut development	The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.		hp.json		http://purl.obolibrary.org/obo/GO_0007494		
GO:0044403	biolink:BiologicalProcess	biological process involved in symbiotic interaction	A process carried out by gene products in an organism that enable the organism to engage in a symbiotic relationship, a more or less intimate association, with another organism. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts.		hp.json	symbiosis|symbiotic process|symbiotic interaction between host and organism|symbiosis, encompassing mutualism through parasitism|symbiotic interaction between organisms|host-pathogen interaction|commensalism|symbiotic interaction between species|parasitism|symbiotic interaction	http://purl.obolibrary.org/obo/GO_0044403		goslim_chembl
HP:0100477	biolink:PhenotypicFeature	Symphalangism affecting the distal phalanx of the 4th toe		UMLS:C4022050	hp.json	Fused outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100477		
HP:0100478	biolink:PhenotypicFeature	Symphalangism affecting the distal phalanx of the 5th toe		UMLS:C4022049	hp.json	Fused outermost bones of the little toe|Fused outermost bones of the pinky toe|Fused outermost bones of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100478		
HP:0100475	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanx of the 5th toe		UMLS:C4022052	hp.json	Fused innermost bone of pinkie toe|Fused innermost bone of pinky toe|Fused innermost bone of little toe	http://purl.obolibrary.org/obo/HP_0100475		
HP:0100476	biolink:PhenotypicFeature	Symphalangism affecting the distal phalanx of the 3rd toe		UMLS:C4022051	hp.json	Fused outermost bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0100476		
HP:0100473	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanx of the 3rd toe		UMLS:C4022054	hp.json	Fused innermost bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0100473		
HP:0100474	biolink:PhenotypicFeature	Symphalangism affecting the proximal phalanx of the 4th toe		UMLS:C4022053	hp.json	Fused innermost bones of 4th toe	http://purl.obolibrary.org/obo/HP_0100474		
HP:0100471	biolink:PhenotypicFeature	Symphalangism affecting the middle phalanx of the 4th toe		UMLS:C4022056	hp.json	Fused middle bones of 4th toe	http://purl.obolibrary.org/obo/HP_0100471		
HP:0100472	biolink:PhenotypicFeature	Symphalangism affecting the middle phalanx of the 5th toe		UMLS:C4022055	hp.json	Fused middle bones of 5th toe	http://purl.obolibrary.org/obo/HP_0100472		
HP:0100470	biolink:PhenotypicFeature	Symphalangism affecting the middle phalanx of the 3rd toe		UMLS:C4022057	hp.json	Fused middle bones of 3rd toe	http://purl.obolibrary.org/obo/HP_0100470		
GO:0044419	biolink:BiologicalProcess	biological process involved in interspecies interaction between organisms	Any process evolved to enable an interaction with an organism of a different species.		hp.json	interspecies interaction with other organisms|interaction with another species|interspecies interaction|interspecies interaction between organisms	http://purl.obolibrary.org/obo/GO_0044419		gocheck_do_not_annotate|goslim_pir|goslim_candida
NBO:0000616	biolink:NamedThing	eye contact	"A nonverbal communication behavior that is characterised by the meeting the eyes between two individuals." [wikipedia:Eye_contact]		hp.json		http://purl.obolibrary.org/obo/NBO_0000616		
NBO:0000613	biolink:NamedThing	nonverbal communication behavior	"Communication behavior related to the process of conveying meaning in the form of non-word messages through for example gesture, body language or posture; facial expression and eye contact etc." [wikipedia:.wikipedia.org/wiki/Nonverbal_communication]		hp.json	non-verbal communication behaviour|nonverbal communication behaviour	http://purl.obolibrary.org/obo/NBO_0000613		
CHEBI:57606	biolink:ChemicalSubstance	5-oxoprolinate	The conjugate base of 5-oxoproline.	Gmelin:327019|Beilstein:4135383	hp.json	5-oxoproline|Pyroglutamate|5-oxopyrrolidine-2-carboxylate|5-oxopyrrolidine-2-carboxylate|5-oxoprolinate anion	http://purl.obolibrary.org/obo/CHEBI_57606		3_STAR
UBERON:0016480	biolink:AnatomicalEntity	interlobular stroma of liver		FMA:17525	hp.json		http://purl.obolibrary.org/obo/UBERON_0016480		pheno_slim
NBO:0000612	biolink:NamedThing	communication behavior	"A social behavior related to the activity of conveying information." [wikipedia:Communication]		hp.json	communicating|signal exchange	http://purl.obolibrary.org/obo/NBO_0000612		
UBERON:0016481	biolink:AnatomicalEntity	bronchial lymph node	A lymph node that is part of a bronchus.	NCIT:C32232|MA:0003078	hp.json		http://purl.obolibrary.org/obo/UBERON_0016481		
CHEBI:33635	biolink:ChemicalSubstance	polycyclic compound			hp.json	polycyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33635		3_STAR
CHEBI:33636	biolink:ChemicalSubstance	bicyclic compound	A molecule that features two fused rings.		hp.json	bicyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33636		3_STAR
NBO:0000617	biolink:NamedThing	laughing behavior			hp.json		http://purl.obolibrary.org/obo/NBO_0000617		
HP:0004554	biolink:PhenotypicFeature	Generalized hypertrichosis	Generalized excessive, abnormal hairiness.	UMLS:C3277940	hp.json	Generalised hypertrichosis	http://purl.obolibrary.org/obo/HP_0004554		
HP:0004558	biolink:PhenotypicFeature	Cervical platyspondyly	A flattened vertebral body shape with reduced distance between the vertebral endplates affecting the cervical spine.	UMLS:C1856641	hp.json	Flattened cervical vertebral bodies	http://purl.obolibrary.org/obo/HP_0004558		
HP:0004557	biolink:PhenotypicFeature	Anterior vertebral fusion		UMLS:C1969393	hp.json		http://purl.obolibrary.org/obo/HP_0004557		
HP:0004552	biolink:PhenotypicFeature	Scarring alopecia of scalp		UMLS:C3806301	hp.json	Hair loss on scalp from scarring condition|Cicatricial alopecia	http://purl.obolibrary.org/obo/HP_0004552		
UBERON:0016475	biolink:AnatomicalEntity	skin of forehead	A zone of skin that is part of a forehead.	EMAPA:37952|FMA:63883	hp.json	forehead skin	http://purl.obolibrary.org/obo/UBERON_0016475		pheno_slim
NBO:0000623	biolink:NamedThing	echolalia	"Stereotypic behavior characterised by a tendency to repeat vocalizations." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000623		
CHEBI:21663	biolink:ChemicalSubstance	N-acylneuraminates			hp.json	N-acylneuraminate	http://purl.obolibrary.org/obo/CHEBI_21663		3_STAR
NBO:0000621	biolink:NamedThing	selective mutism	"A communication disorder in which a person, most often a child, who is normally capable of speech is unable to speak in given situations, or to specific people." [wikipedia:Selective_mutism]		hp.json		http://purl.obolibrary.org/obo/NBO_0000621		
NBO:0000620	biolink:NamedThing	frustration behavior	"An emotional behavior that arises from the perceived resistance to the fulfillment of individual will." [wikipedia:Frustration]		hp.json		http://purl.obolibrary.org/obo/NBO_0000620		
UBERON:0016476	biolink:AnatomicalEntity	primary incisor tooth	An incisor tooth that is part of a primary dentition.	FMA:84200	hp.json	deciduous incisor tooth|temporary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0016476		pheno_slim
UBERON:0016479	biolink:AnatomicalEntity	capsule of liver	A collagenous capsule covering the external surface of the liver.	FMA:15813	hp.json	hepatic capsule|glisson's capsule|fibrous capsule of Glisson|liver capsule|tunica fibrosa hepatis|tunica fibrosa (hepar)|capsula fibrosa perivascularis|fibrous capsule of liver	http://purl.obolibrary.org/obo/UBERON_0016479		
UBERON:0016478	biolink:AnatomicalEntity	liver stroma	A stroma that is part of a liver.	FMA:17553	hp.json	hepatic stroma|stroma of liver	http://purl.obolibrary.org/obo/UBERON_0016478		human_reference_atlas
UBERON:0004495	biolink:AnatomicalEntity	skeletal muscle tissue of diaphragm	A portion of skeletal muscle tissue that is part of a diaphragm [Automatically generated definition].	FMA:261898	hp.json		http://purl.obolibrary.org/obo/UBERON_0004495		
OBO:pr#has_gene_template	biolink:Protein	has_gene_template			hp.json		http://purl.obolibrary.org/obo/pr#has_gene_template		
HP:0004566	biolink:PhenotypicFeature	Pear-shaped vertebrae	Bulbous appearance of the anterior vertebral bodies, such that the vertebral bodies have the greatest vertical height anteriorly as well as bulbous anterior superior-inferior contours.	UMLS:C1866731	hp.json	Pear-shaped vertebral bodies	http://purl.obolibrary.org/obo/HP_0004566		
UBERON:0004493	biolink:AnatomicalEntity	cardiac muscle tissue of myocardium	A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition].	EMAPA:32688|FMA:261726|MA:0002441	hp.json		http://purl.obolibrary.org/obo/UBERON_0004493		pheno_slim
HP:0004565	biolink:PhenotypicFeature	Severe platyspondyly		UMLS:C1850293	hp.json	platyspondyly, extreme	http://purl.obolibrary.org/obo/HP_0004565		
UBERON:0004491	biolink:AnatomicalEntity	cardiac muscle tissue of interatrial septum	A portion of cardiac muscle tissue that is part of a interatrial septum [Automatically generated definition].	FMA:84083	hp.json	interatrial septum myocardium|interatrial septum myocardium|interatrial septum heart muscle|interatrial septum heart muscle|interatrial septum cardiac muscle tissue|interatrial septum cardiac muscle tissue|interatrial septum muscle|interatrial septum muscle	http://purl.obolibrary.org/obo/UBERON_0004491		
UBERON:0004492	biolink:AnatomicalEntity	cardiac muscle tissue of cardiac septum	A portion of cardiac muscle tissue that is part of a cardiac septum [Automatically generated definition].	FMA:226279	hp.json	cardiac septum cardiac muscle tissue|cardiac septum cardiac muscle tissue|cardiac septum muscle|cardiac septum muscle|cardiac septum myocardium|cardiac septum myocardium|cardiac septum heart muscle|cardiac septum heart muscle	http://purl.obolibrary.org/obo/UBERON_0004492		
HP:0004568	biolink:PhenotypicFeature	Beaking of vertebral bodies	Anterior tongue-like protrusions of the vertebral bodies.	SNOMEDCT_US:19888007|UMLS:C0264112|UMLS:C1856599	hp.json	Anterior beaking of vertebrae|Vertebral tongue-like protrusion|anterior beaking|Anterior beaking of vertebral bodies|Beaked vertebral bodies	http://purl.obolibrary.org/obo/HP_0004568		hposlim_core
UBERON:0004490	biolink:AnatomicalEntity	cardiac muscle tissue of atrium	A portion of cardiac muscle tissue that is part of an atrium [Automatically generated definition].	FMA:7283	hp.json	cardiac atrium muscle|atrial heart muscle|atrial cardiac muscle tissue|atrial myocardium	http://purl.obolibrary.org/obo/UBERON_0004490		
HP:0004563	biolink:PhenotypicFeature	Increased spinal bone density	Increased bone density affecting the bones of the spine (vertebral column).	UMLS:C4020828|UMLS:C4280515|UMLS:C4280514|UMLS:C4280513|UMLS:C4280254	hp.json	Compact spinal bone|Concrete spinal bone|Sclerosis of spinal bone|Increased density of spinal bone|Increased spinal bone density Z-score|Ivory spinal bone|Dense spinal bone|Eburnation of spinal bone	http://purl.obolibrary.org/obo/HP_0004563		
UBERON:0004499	biolink:AnatomicalEntity	skeletal muscle tissue of tibialis anterior	A portion of skeletal muscle tissue that is part of a tibialis anterior [Automatically generated definition].	FMA:262004	hp.json		http://purl.obolibrary.org/obo/UBERON_0004499		
HP:0004562	biolink:PhenotypicFeature	Beaking of vertebral bodies T12-L3		UMLS:C1854941	hp.json		http://purl.obolibrary.org/obo/HP_0004562		
UBERON:0004498	biolink:AnatomicalEntity	skeletal muscle tissue of quadriceps femoris	A portion of skeletal muscle tissue that is part of a quadriceps femoris [Automatically generated definition].	FMA:261998	hp.json		http://purl.obolibrary.org/obo/UBERON_0004498		
UBERON:0016462	biolink:AnatomicalEntity	periorbital skin	A zone of skin in the periorbital region of the face.	FMA:59350|EMAPA:37937	hp.json	skin of orbital part of face	http://purl.obolibrary.org/obo/UBERON_0016462		pheno_slim
UBERON:0016464	biolink:AnatomicalEntity	dorsum of nose	The midline prominence of the nose, extending from the nasal root to the tip.	FMA:59517	hp.json	nasal ridge|nasal dorsum	http://purl.obolibrary.org/obo/UBERON_0016464		pheno_slim
UBERON:0016466	biolink:AnatomicalEntity	antihelix	On the pinna, a curved prominence of cartilage, parallel with and in front of the helix, is called the antihelix, also known as the anthelix; this divides above into two crura, the crura antihelicis, between which is a triangular depression, the fossa triangularis.	FMA:60995|NCIT:C32120	hp.json	antihelix (auricula)|antihelix of pinna|antihelical part of pinna|anthelix	http://purl.obolibrary.org/obo/UBERON_0016466		pheno_slim
UBERON:0016467	biolink:AnatomicalEntity	antitragus	The antitragus is a feature of human ear anatomy. It is a small tubercle that points anteriorly. It is separated from the tragus by the intertragic notch.	NCIT:C32121|FMA:61001	hp.json	antitragal part of pinna	http://purl.obolibrary.org/obo/UBERON_0016467		pheno_slim
UBERON:0004482	biolink:AnatomicalEntity	musculature of lower limb	Any collection of muscles that is part of a hindlimb [Automatically generated definition].	FMA:50399	hp.json	muscle group of free lower limb|free lower limb musculature|musculature of free lower limb|set of muscles of free lower limb	http://purl.obolibrary.org/obo/UBERON_0004482		pheno_slim
HP:0004532	biolink:PhenotypicFeature	Sacral hypertrichosis	Excessive, increased hair growth located in the sacral region.	UMLS:C4025313	hp.json		http://purl.obolibrary.org/obo/HP_0004532		
UBERON:0004480	biolink:AnatomicalEntity	musculature of limb	Any collection of muscles that is part of a limb [Automatically generated definition].	EMAPA:32700|FMA:50188|EHDAA2:0000995	hp.json	muscle group of limb|limb muscle system|limb musculature|set of muscles of limb	http://purl.obolibrary.org/obo/UBERON_0004480		pheno_slim
UBERON:0004481	biolink:AnatomicalEntity	musculature of upper limb	Any collection of muscles that is part of a forelimb [Automatically generated definition].	FMA:50396	hp.json	muscle group of free upper limb|free upper limb musculature|musculature of free upper limb|set of muscles of free upper limb	http://purl.obolibrary.org/obo/UBERON_0004481		pheno_slim
HP:0004535	biolink:PhenotypicFeature	Anterior cervical hypertrichosis	Anterior cervical hypertrichosis (ACH) or 'hairy throat' refers to the presence of a tuft of terminal hair on the anterior neck, just above the laryngeal prominence.	UMLS:C1838123|MSH:C538390	hp.json	Hypertrichosis, congenital anterior cervical|Congenital cervical hypertrichosis	http://purl.obolibrary.org/obo/HP_0004535		
UBERON:0004488	biolink:AnatomicalEntity	musculature of pes	Any collection of muscles that is part of a foot [Automatically generated definition].	FMA:50214	hp.json	foot musculature|set of muscles of foot|musculature of foot|muscle group of foot	http://purl.obolibrary.org/obo/UBERON_0004488		pheno_slim
UBERON:0004489	biolink:AnatomicalEntity	musculature of manus	Any collection of muscles that is part of a manus [Automatically generated definition].	FMA:42368	hp.json	set of muscles of hand|musculature of hand|muscle group of hand|hand musculature	http://purl.obolibrary.org/obo/UBERON_0004489		pheno_slim
UBERON:0004486	biolink:AnatomicalEntity	musculature of perineum	Any collection of muscles that is part of a perineum [Automatically generated definition].	EMAPA:36629|FMA:71295	hp.json	set of perineal muscles|musculi perinei|perineal muscles set|perineal muscles	http://purl.obolibrary.org/obo/UBERON_0004486		
UBERON:0004487	biolink:AnatomicalEntity	musculature of forelimb zeugopod	Any collection of muscles that is part of a lower arm [Automatically generated definition].	FMA:39089	hp.json	musculature of forearm|set of muscles of forearm|muscle group of forearm	http://purl.obolibrary.org/obo/UBERON_0004487		
NBO:0000605	biolink:NamedThing	sexual inhibition	"A social behavior characterised by conscious or unconscious constraint or curtailment of behavior relating to specific sexual matters or practices." [wikipedia:Sexual_inhibition]		hp.json		http://purl.obolibrary.org/obo/NBO_0000605		
NBO:0000604	biolink:NamedThing	social inhibition	"A social behavior characterised by conscious or unconscious constraint of a behavior that might be considered objectionable in a social setting." [wikipedia:Social_inhibition]		hp.json		http://purl.obolibrary.org/obo/NBO_0000604		
UBERON:0016453	biolink:AnatomicalEntity	lower secondary premolar tooth		FMA:55717	hp.json	lower permanent premolar tooth|mandibular secondary premolar tooth|permanent lower premolar tooth	http://purl.obolibrary.org/obo/UBERON_0016453		pheno_slim
NBO:0000603	biolink:NamedThing	delusion	"A belief that is either mistaken or not substantiated that is held with vehemence." [wikipedia:Delusion]		hp.json		http://purl.obolibrary.org/obo/NBO_0000603		
UBERON:0016452	biolink:AnatomicalEntity	upper secondary premolar tooth		FMA:55716	hp.json	secondary upper premolar tooth|upper permanent premolar tooth|permanent upper premolar tooth|maxillary secondary premolar tooth	http://purl.obolibrary.org/obo/UBERON_0016452		pheno_slim
NBO:0000602	biolink:NamedThing	apathy	"Exhibiting indifference, or suppression of emotions such as concern, excitement, motivation and passion." [wikipedia:Indifference_(emotion)]		hp.json	impassivity|perfunctoriness	http://purl.obolibrary.org/obo/NBO_0000602		
NBO:0000601	biolink:NamedThing	emotional behavior phenotype	"Observable characteristic of behavior related to the complex psychophysiological experience of an individual's state of mind as interacting with biochemical (internal) and environmental (external) influences." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000601		
CHEBI:21644	biolink:ChemicalSubstance	N-acyl-L-amino acid	Any N-acylamino acid having L-configuration.		hp.json		http://purl.obolibrary.org/obo/CHEBI_21644		3_STAR
UBERON:0016459	biolink:AnatomicalEntity	posterior pole of lens	The central point on the posterior surface of the lens.	NCIT:C33375|FMA:58898	hp.json	polus posterior (lens)|polus posterior lentis	http://purl.obolibrary.org/obo/UBERON_0016459		pheno_slim
UBERON:0016458	biolink:AnatomicalEntity	esophageal hiatus	A hole in the diaphragm through which the esophagus passes.	FMA:58289	hp.json	esophageal hiatus of diaphragm|oesophageal hiatus|oesophageal aperture	http://purl.obolibrary.org/obo/UBERON_0016458		pheno_slim
UBERON:0016455	biolink:AnatomicalEntity	upper lateral secondary incisor tooth		FMA:55724	hp.json	maxillary lateral secondary incisor tooth|upper lateral permanent incisor tooth	http://purl.obolibrary.org/obo/UBERON_0016455		pheno_slim
NBO:0000608	biolink:NamedThing	hallucination	"Perception in the absence of a stimulus." [wikipedia:Hallucination]		hp.json		http://purl.obolibrary.org/obo/NBO_0000608		
UBERON:0016454	biolink:AnatomicalEntity	upper central secondary incisor tooth		FMA:55722	hp.json	permanent upper central incisor tooth|maxillary central secondary incisor tooth|maxillary central permanent incisor tooth|upper central permanent incisor tooth	http://purl.obolibrary.org/obo/UBERON_0016454		pheno_slim
NBO:0000607	biolink:NamedThing	cognitive behavior	"Behaviour related to cognitive processes." [NBO:JH]		hp.json		http://purl.obolibrary.org/obo/NBO_0000607		
NBO:0000606	biolink:NamedThing	forgetfulness	"Loss of information already encoded and stored in an individual's long term memory." [wikipedia:Forgetting]		hp.json	retention loss|pathological forgetting	http://purl.obolibrary.org/obo/NBO_0000606		
UBERON:0004473	biolink:AnatomicalEntity	musculature of face	Any collection of muscles that is part of a face.	FMA:71288	hp.json	musculi faciei|entire facial musculature|facial muscles|entire facial musculature|set of muscles of face|muscle group of face|set of facial muscles	http://purl.obolibrary.org/obo/UBERON_0004473		pheno_slim
UBERON:0004474	biolink:AnatomicalEntity	musculature of arm	Any collection of muscles that is part of an arm [Automatically generated definition].	EHDAA2:0000141	hp.json	muscle group of arm|arm musculature|arm muscle system|set of muscles of arm	http://purl.obolibrary.org/obo/UBERON_0004474		pheno_slim
HP:0004544	biolink:PhenotypicFeature	obsolete Pointed frontal hairline			hp.json		http://purl.obolibrary.org/obo/HP_0004544		
UBERON:0004471	biolink:AnatomicalEntity	musculature of pectoral girdle	A subdivision of the musculature of the body in the pectoral girdle region. Includes pectoral and shoulder muscles.	AAO:0000423|FMA:33519|EMAPA:37857	hp.json	muscle group of pectoral girdle|pectoral girdle musculature|pectoral girdle muscles|set of muscles of pectoral girdle	http://purl.obolibrary.org/obo/UBERON_0004471		pheno_slim
GO:0140353	biolink:BiologicalProcess	lipid export from cell	The directed movement of a lipid from a cell, into the extracellular region.		hp.json	lipid efflux	http://purl.obolibrary.org/obo/GO_0140353		
UBERON:0004470	biolink:AnatomicalEntity	musculature of pelvic girdle	Any collection of muscles that is part of a pelvic girdle [Automatically generated definition].	EMAPA:18184|EHDAA2:0001429|AAO:0000427|FMA:50205|FMA:50248	hp.json	set of muscles of pelvis|set of muscles of pelvic girdle|pelvic girdle muscles|muscle group of pelvis|muscular system of pelvis|pelvic girdle muscle system|muscle group of pelvic girdle|pelvic girdle musculature	http://purl.obolibrary.org/obo/UBERON_0004470		pheno_slim
GO:0140352	biolink:BiologicalProcess	export from cell	The directed movement of some substance from a cell, into the extracellular region. This may occur via transport across the plasma membrane or via exocytosis.		hp.json	efflux	http://purl.obolibrary.org/obo/GO_0140352		
GO:0140354	biolink:BiologicalProcess	lipid import into cell	The directed movement of a lipid from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.		hp.json	lipid uptake	http://purl.obolibrary.org/obo/GO_0140354		
UBERON:0004479	biolink:AnatomicalEntity	musculature of trunk	Any collection of muscles that is part of a trunk [Automatically generated definition].	AAO:0011572|FMA:50187|EFO:0003531	hp.json	muscle group of trunk|muscular system of trunk|set of muscles of trunk	http://purl.obolibrary.org/obo/UBERON_0004479		pheno_slim|efo_slim
HP:0004540	biolink:PhenotypicFeature	Congenital, generalized hypertrichosis	A confluent, generalized overgrowth of silvery blonde to gray lanugo hair at birth.	UMLS:C1855900|MSH:C538388	hp.json	Congenital generalised hypertrichosis|Congenital, generalised hypertrichosis|Hypertrichosis universalis|Congenital generalized hypertrichosis	http://purl.obolibrary.org/obo/HP_0004540		
UBERON:0004478	biolink:AnatomicalEntity	musculature of larynx	The collection of muscles that are part of the larynx.	Wikipedia:Muscles_of_larynx|FMA:46616|MESH:D007821|FMA:264611	hp.json	set of laryngeal muscles|muscle group of larynx|laryngeal muscles set|laryngeal muscles|set of muscles of larynx	http://purl.obolibrary.org/obo/UBERON_0004478		
UBERON:0004475	biolink:AnatomicalEntity	musculature of hip	The collection of muscles that form attachments to the hip skeleton.	FMA:50227	hp.json	muscle group of hip|hip musculature|set of muscles of hip	http://purl.obolibrary.org/obo/UBERON_0004475		pheno_slim
UBERON:0004476	biolink:AnatomicalEntity	musculature of shoulder	The collection of muscles that form attachments to the shoulder skeleton.	FMA:50220	hp.json	set of muscles of shoulder|muscle group of shoulder	http://purl.obolibrary.org/obo/UBERON_0004476		pheno_slim
PR:P00797	biolink:Protein	renin (human)	A renin that is encoded in the genome of human.	UniProtKB:P00797	hp.json	angiotensinogenase (human)|REN|hREN	http://purl.obolibrary.org/obo/PR_P00797		
NBO:0000656	biolink:NamedThing	somatic sensation related behavior phenotype	"A phenotype manifested by a behavior related to the sensations arising from the skin and from the muscles, tendons, and joints." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000656		
NBO:0000655	biolink:NamedThing	sensation behavior phenotype	"Observable characteristic of behavior related any of the five senses -- vision, touch, smell, taste, and hearing." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000655		
HP:0004599	biolink:PhenotypicFeature	Absent or minimally ossified vertebral bodies		UMLS:C1832983	hp.json		http://purl.obolibrary.org/obo/HP_0004599		
HP:0004598	biolink:PhenotypicFeature	Supernumerary vertebral ossification centers	Three ossification sites are present in typical vertebral bodies (C3-L5): a single ossification center in the vertebral body, and one each in the two neural arches. This term applies if there are additional vertebral ossification centers present during the development and maturation of the spine.	UMLS:C4025309	hp.json	Supernumerary vertebral ossification centres	http://purl.obolibrary.org/obo/HP_0004598		
HP:0004592	biolink:PhenotypicFeature	Thoracic platyspondyly	A flattened vertebral body shape with reduced distance beween the vertebral endplates affecting the thoracic spine.	UMLS:C1862428	hp.json		http://purl.obolibrary.org/obo/HP_0004592		
HP:0004591	biolink:PhenotypicFeature	Disc-like vertebral bodies		UMLS:C1835444	hp.json		http://purl.obolibrary.org/obo/HP_0004591		
HP:0004590	biolink:PhenotypicFeature	Hypoplastic sacrum		UMLS:C1970816	hp.json	Small sacrum	http://purl.obolibrary.org/obo/HP_0004590		
PATO:0002182	biolink:NamedThing	molecular quality	A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc.		hp.json	relational molecular quality	http://purl.obolibrary.org/obo/PATO_0002182		
CHEBI:21619	biolink:ChemicalSubstance	N-acetylneuraminates			hp.json	N-acetylneuraminate	http://purl.obolibrary.org/obo/CHEBI_21619		3_STAR
HP:0004594	biolink:PhenotypicFeature	Hump-shaped mound of bone in central and posterior portions of vertebral endplate		UMLS:C1839252	hp.json		http://purl.obolibrary.org/obo/HP_0004594		
PATO:0002180	biolink:NamedThing	straight	A shape quality inhering in a bearer by virtue of the bearer's being free of curves, bends, or angles.		hp.json		http://purl.obolibrary.org/obo/PATO_0002180		value_slim
PATO:0002181	biolink:NamedThing	displaced	A positional quality inhering in a bearer by virtue the bearer's being changed in position.		hp.json		http://purl.obolibrary.org/obo/PATO_0002181		attribute_slim
CHEBI:21622	biolink:ChemicalSubstance	N-acetylneuraminic acids			hp.json		http://purl.obolibrary.org/obo/CHEBI_21622		3_STAR
CHEBI:33608	biolink:ChemicalSubstance	hydrogen molecular entity			hp.json	hydrogen compounds|hydrogen molecular entities	http://purl.obolibrary.org/obo/CHEBI_33608		3_STAR
PATO:0002198	biolink:NamedThing	quality of a substance	A quality inhering in a bearer by virtue of its constitution.		hp.json		http://purl.obolibrary.org/obo/PATO_0002198		attribute_slim
HP:0100501	biolink:PhenotypicFeature	Recurrent bronchiolitis	An increased susceptibility to bronchiolitis as manifested by a history of recurrent bronchiolitis.	UMLS:C4015136	hp.json		http://purl.obolibrary.org/obo/HP_0100501		
HP:0100502	biolink:PhenotypicFeature	Vitamin B12 deficiency		MSH:D014806|UMLS:C0042847|SNOMEDCT_US:190634004	hp.json	Vitamin B12 deficiency	http://purl.obolibrary.org/obo/HP_0100502		
HP:0100500	biolink:PhenotypicFeature	Fibular deviation of toes		UMLS:C4020970	hp.json	Lateral deviation of toes	http://purl.obolibrary.org/obo/HP_0100500		
HP:0004576	biolink:PhenotypicFeature	Sclerotic vertebral endplates	Sclerosis (increased density) affecting vertebral end plates.	UMLS:C1859698	hp.json	Endplate sclerosis	http://purl.obolibrary.org/obo/HP_0004576		
HP:0004575	biolink:PhenotypicFeature	Fusion of midcervical facet joints		UMLS:C1847394	hp.json		http://purl.obolibrary.org/obo/HP_0004575		
HP:0100509	biolink:PhenotypicFeature	Abnormality of vitamin C metabolism		UMLS:C4021863	hp.json	Abnormality of vitamin C metabolism	http://purl.obolibrary.org/obo/HP_0100509		
HP:0004570	biolink:PhenotypicFeature	Increased vertebral height	Increased top to bottom height of vertebral bodies.	UMLS:C1864853	hp.json	Tall vertebral bodies	http://purl.obolibrary.org/obo/HP_0004570		
HP:0100507	biolink:PhenotypicFeature	Reduced blood folate concentration	A reduced circulating concentration of folic acid, which is also known as vitamin B9.	UMLS:C0016412|MSH:D005494|SNOMEDCT_US:190633005	hp.json	Vitamin B9 deficiency|Folate deficiency	http://purl.obolibrary.org/obo/HP_0100507		
HP:0100508	biolink:PhenotypicFeature	Abnormality of vitamin metabolism	An anomaly in the metabolism of a vitamin.	UMLS:C4022036	hp.json	Abnormality of vitamin metabolism	http://purl.obolibrary.org/obo/HP_0100508		
HP:0100505	biolink:PhenotypicFeature	Low levels of vitamin B5	A reduced concentration of vitamin B5.	UMLS:C4022038	hp.json	Vitamin B5 deficiency	http://purl.obolibrary.org/obo/HP_0100505		
HP:0004573	biolink:PhenotypicFeature	Anterior wedging of T11	An abnormality of the shape of the thoracic vertebra T11 such that it is wedge-shaped (narrow towards the front).	UMLS:C4021652	hp.json	Anterior wedging of the 11th thoracic vertebra|Wedge-shaped 11th thoracic vertebra	http://purl.obolibrary.org/obo/HP_0004573		
HP:0100506	biolink:PhenotypicFeature	Low levels of vitamin B8	A reduced concentration of vitamin B8.	UMLS:C4022037	hp.json	Vitamin B8 deficiency	http://purl.obolibrary.org/obo/HP_0100506		
HP:0100503	biolink:PhenotypicFeature	Low levels of vitamin B1	A reduced concentration of vitamin B1.	UMLS:C0039841|SNOMEDCT_US:399357009|MSH:D013832	hp.json	Vitamin B1 deficiency|Reduced blood thiamine level	http://purl.obolibrary.org/obo/HP_0100503		
HP:0004571	biolink:PhenotypicFeature	Widening of cervical spinal canal		UMLS:C3807591	hp.json		http://purl.obolibrary.org/obo/HP_0004571		
HP:0100504	biolink:PhenotypicFeature	Low levels of vitamin B2	A reduced concentration of vitamin B2.	UMLS:C0035528|MSH:D012257|SNOMEDCT_US:20307000	hp.json	Riboflavin deficiency|Vitamin B2 deficiency	http://purl.obolibrary.org/obo/HP_0100504		
HP:0100512	biolink:PhenotypicFeature	Low levels of vitamin D	A reduced concentration of Vitamin D.	SNOMEDCT_US:34713006|UMLS:C0042870|MSH:D014808	hp.json	Deficient in vitamin D|Vitamin D deficiency	http://purl.obolibrary.org/obo/HP_0100512		
HP:0100513	biolink:PhenotypicFeature	Low levels of vitamin E	A reduced concentration of vitamin E in the blood circulation. Vitamin E is a lipophilic vitamin that is also known as alpha-tocopherol.	MSH:D014811|UMLS:C0042875|SNOMEDCT_US:54137008	hp.json	Alpha-tocopherol deficiency|Vitamin E deficiency	http://purl.obolibrary.org/obo/HP_0100513		
HP:0100510	biolink:PhenotypicFeature	Low levels of vitamin C	A reduced concentration of Vitamin C.	MSH:D001206|SNOMEDCT_US:76169001|UMLS:C0003969	hp.json	Vitamin C deficiency	http://purl.obolibrary.org/obo/HP_0100510		
HP:0100511	biolink:PhenotypicFeature	Abnormality of vitamin D metabolism		UMLS:C4022035	hp.json	Abnormality of vitamin D metabolism	http://purl.obolibrary.org/obo/HP_0100511		
UBERON:0016491	biolink:AnatomicalEntity	vertebral centrum element	Skeletal element that functionally replaces the notochord[VSAP,modified].	VSAO:0000183	hp.json	centrum|centrum of vertebra	http://purl.obolibrary.org/obo/UBERON_0016491		
UBERON:0016490	biolink:AnatomicalEntity	auditory system	Is the sensory system for the sense of hearing.	FMA:7192|Wikipedia:Auditory_system|UMLS:C0587901|NCIT:C12889|EMAPA:36002|MA:0002443|NLXANAT:090817|OpenCyc:Mx4rvViwtJwpEbGdrcN5Y29ycA|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2888	hp.json		http://purl.obolibrary.org/obo/UBERON_0016490		
NBO:0000644	biolink:NamedThing	voluntary movement behavior phenotype	"Observable characteristic of behavior related to movements executed with intent." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000644		
NBO:0000643	biolink:NamedThing	involuntary movement behavior phenotype	"Observable characteristic of behavior related to movements that occur independent of planning." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000643		
OBO:chebi#is_enantiomer_of	biolink:NamedThing	is enantiomer of			hp.json		http://purl.obolibrary.org/obo/chebi#is_enantiomer_of		
HP:0004589	biolink:PhenotypicFeature	Dysplasia of second lumbar vertebra		UMLS:C4025310	hp.json		http://purl.obolibrary.org/obo/HP_0004589		
HP:0004586	biolink:PhenotypicFeature	Biconcave vertebral bodies	Exaggerated concavity of the anterior or posterior surface of the vertebral body, i.e., the upper and lower vertebral endplates are hollowed inward.	UMLS:C1856087	hp.json	Biconcave 'codfish' vertebrae|Scalloping of vertebral bodies|Codfish vertebrae|Fish vertebrae|Biconcave vertebrae	http://purl.obolibrary.org/obo/HP_0004586		hposlim_core
HP:0004581	biolink:PhenotypicFeature	Increased anterior vertebral height		UMLS:C1866732	hp.json		http://purl.obolibrary.org/obo/HP_0004581		
HP:0004580	biolink:PhenotypicFeature	Anterior scalloping of vertebral bodies	An excessive concavity of the anterior surface of one or more vertebral bodies.	UMLS:C2673652	hp.json	Anterior scalloping vertebral bodies	http://purl.obolibrary.org/obo/HP_0004580		
HP:0100518	biolink:PhenotypicFeature	Dysuria	Painful or difficult urination.	MSH:D053159|UMLS:C0013428|SNOMEDCT_US:49650001	hp.json	Dull burning sensation with urination|Painful or difficult urination	http://purl.obolibrary.org/obo/HP_0100518		
HP:0100519	biolink:PhenotypicFeature	Anuria	Absence of urine, clinically classified as below 50ml/day.	UMLS:C0003460|SNOMEDCT_US:2472002|MSH:D001002	hp.json	Absent urine output	http://purl.obolibrary.org/obo/HP_0100519		
HP:0100516	biolink:PhenotypicFeature	Neoplasm of the ureter	The presence of a neoplasm of the ureter.	SNOMEDCT_US:126882009|UMLS:C0041955|NCIT:C3262|MSH:D014516|SNOMEDCT_US:363458004|UMLS:C0153619	hp.json	ureter, cancer of|Neoplasia of the ureters	http://purl.obolibrary.org/obo/HP_0100516		
HP:0100517	biolink:PhenotypicFeature	Neoplasm of the urethra	The presence of a neoplasm of the urethra.	SNOMEDCT_US:126883004|MSH:D014523|UMLS:C0041971|NCIT:C2974	hp.json	Neoplasia of the urethra	http://purl.obolibrary.org/obo/HP_0100517		
HP:0100514	biolink:PhenotypicFeature	Abnormality of vitamin E metabolism		UMLS:C4022034	hp.json	Abnormality of vitamin E metabolism	http://purl.obolibrary.org/obo/HP_0100514		
HP:0100515	biolink:PhenotypicFeature	Pollakisuria	Increased frequency of urination.	SNOMEDCT_US:300471006|SNOMEDCT_US:162116003|UMLS:C0042023	hp.json	Frequent urination|Constant urination	http://purl.obolibrary.org/obo/HP_0100515		
HP:0004582	biolink:PhenotypicFeature	Irregularity of vertebral bodies		UMLS:C4025311	hp.json		http://purl.obolibrary.org/obo/HP_0004582		
CHEBI:18085	biolink:ChemicalSubstance	glycosaminoglycan	Any polysaccharide containing a substantial proportion of aminomonosaccharide residues.	Wikipedia:Glycosaminoglycan|KEGG:C02545	hp.json	glycosaminoglycan|Glykosaminoglykan|Glycosaminoglycan|glycosaminoglycane|glycosaminoglycans|glicosaminoglicano	http://purl.obolibrary.org/obo/CHEBI_18085		3_STAR
GO:0044380	biolink:BiologicalProcess	protein localization to cytoskeleton	A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.		hp.json	protein localisation to cytoskeleton	http://purl.obolibrary.org/obo/GO_0044380		
UBERON:0004419	biolink:AnatomicalEntity	proximal epiphysis of phalanx of manual digit 3	A proximal epiphysis that is part of a manual digit 3 phalanx [Automatically generated definition].	FMA:37510	hp.json	proximal epiphysis of phalanx of middle finger|base of phalanx of third finger|proximal epiphysis of phalanx of manual digit 3|basal epiphysis of phalanx of middle finger|base of phalanx of third digit of hand|base of phalanx of middle finger|proximal epiphysis of phalanx of manual digit III	http://purl.obolibrary.org/obo/UBERON_0004419		
UBERON:0004417	biolink:AnatomicalEntity	proximal epiphysis of phalanx of manual digit 1	A proximal epiphysis that is part of a manual digit 1 phalanx [Automatically generated definition].	FMA:37489	hp.json	basal epiphysis of phalanx of thumb|proximal epiphysis of phalanx of manual digit 1|base of phalanx of thumb|base of phalanx of first digit of hand|proximal epiphysis of phalanx of manual digit I|proximal epiphysis of phalanx of thumb	http://purl.obolibrary.org/obo/UBERON_0004417		
UBERON:0004418	biolink:AnatomicalEntity	proximal epiphysis of phalanx of manual digit 2	A proximal epiphysis that is part of a manual digit 2 phalanx [Automatically generated definition].	FMA:37498	hp.json	proximal epiphysis of phalanx of manual digit 2|basal epiphysis of phalanx of index finger|proximal epiphysis of phalanx of index finger|proximal epiphysis of phalanx of manual digit II|base of phalanx of second digit of hand|base of phalanx of index finger|base of phalanx of second finger	http://purl.obolibrary.org/obo/UBERON_0004418		
UBERON:0016404	biolink:AnatomicalEntity	cervical vertebral arch joint	A vertebral arch joint that is part of a cervical region of vertebral column.	FMA:13668	hp.json	cervical facet joint|zygapophyseal joint of cervical vertebrae|joint of cervical vertebral arch|joint of cervical vertebral articular process|zygapophysial joint of cervical vertebrae	http://purl.obolibrary.org/obo/UBERON_0016404		pheno_slim
UBERON:0016405	biolink:AnatomicalEntity	pulmonary capillary	A capillary that is part of a lung.	FMA:14121	hp.json	capillary of lung	http://purl.obolibrary.org/obo/UBERON_0016405		pheno_slim|human_reference_atlas
PATO:0002149	biolink:NamedThing	ivory	A quality inhering in a bearer by virtue of the bearer exhibiting increased density resulting in exhibiting increased degree of radiopacity (in X-rays).		hp.json		http://purl.obolibrary.org/obo/PATO_0002149		value_slim
UBERON:0016400	biolink:AnatomicalEntity	infrapatellar fat pad	The infrapatellar fat pad, also known as Hoffa's fat pad, is a cylindrical piece of fat that is situated under and behind the patella bone within the knee.	FMA:58772	hp.json		http://purl.obolibrary.org/obo/UBERON_0016400		human_reference_atlas
PATO:0002142	biolink:NamedThing	bracket			hp.json		http://purl.obolibrary.org/obo/PATO_0002142		value_slim
PATO:0002143	biolink:NamedThing	sloped downward			hp.json		http://purl.obolibrary.org/obo/PATO_0002143		value_slim
PATO:0002141	biolink:NamedThing	irregular density	A density quality which lacks pattern.		hp.json		http://purl.obolibrary.org/obo/PATO_0002141		value_slim
UBERON:0004426	biolink:AnatomicalEntity	proximal epiphysis of fifth metacarpal bone	A proximal epiphysis that is part of a metacarpal bone of digit 5 [Automatically generated definition].	FMA:42800	hp.json	proximal epiphysis of metacarpal 5|base of fifth metacarpal bone|fifth metacarpal bone base|proximal end of fifth metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004426		
UBERON:0004427	biolink:AnatomicalEntity	proximal epiphysis of first metatarsal bone	A proximal epiphysis that is part of a metatarsal bone of digit 1 [Automatically generated definition].	FMA:42963	hp.json	base of first metatarsal bone|proximal end of first metatarsal bone|proximal epiphysis of metatarsal 1	http://purl.obolibrary.org/obo/UBERON_0004427		
UBERON:0004424	biolink:AnatomicalEntity	proximal epiphysis of third metacarpal bone	A proximal epiphysis that is part of a metacarpal bone of digit 3 [Automatically generated definition].	FMA:42794	hp.json	base of third metacarpal bone|third metacarpal bone base|proximal end of third metacarpal bone|proximal epiphysis of metacarpal 3	http://purl.obolibrary.org/obo/UBERON_0004424		
UBERON:0004425	biolink:AnatomicalEntity	proximal epiphysis of fourth metacarpal bone	A proximal epiphysis that is part of a metacarpal bone of digit 4 [Automatically generated definition].	FMA:42797	hp.json	base of fourth metacarpal bone|proximal epiphysis of metacarpal 4|proximal end of fourth metacarpal bone|fourth metacarpal bone base	http://purl.obolibrary.org/obo/UBERON_0004425		
UBERON:0004422	biolink:AnatomicalEntity	proximal epiphysis of first metacarpal bone	A proximal epiphysis that is part of a metacarpal bone of digit 1 [Automatically generated definition].	FMA:42788	hp.json	first metacarpal bone base|proximal epiphysis of metacarpal 1|base of first metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004422		
UBERON:0004423	biolink:AnatomicalEntity	proximal epiphysis of second metacarpal bone	A proximal epiphysis that is part of a metacarpal bone of digit 2 [Automatically generated definition].	FMA:42791	hp.json	second metacarpal bone base|proximal end of second metacarpal bone|proximal epiphysis of metacarpal 2|base of second metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004423		
UBERON:0004420	biolink:AnatomicalEntity	proximal epiphysis of phalanx of manual digit 4	A proximal epiphysis that is part of a manual digit 4 phalanx [Automatically generated definition].	FMA:37522	hp.json	base of phalanx of ring finger|proximal epiphysis of phalanx of manual digit IV|proximal epiphysis of phalanx of ring finger|proximal epiphysis of phalanx of manual digit 4|basal epiphysis of phalanx of ring finger|base of phalanx of fourth finger|base of phalanx of fourth digit of hand	http://purl.obolibrary.org/obo/UBERON_0004420		
UBERON:0004421	biolink:AnatomicalEntity	proximal epiphysis of phalanx of manual digit 5	A proximal epiphysis that is part of a manual digit 5 phalanx [Automatically generated definition].	FMA:37534	hp.json	base of phalanx of fifth digit of hand|basal epiphysis of phalanx of little finger|basal epiphysis of phalanx of fifth finger|proximal epiphysis of phalanx of manual digit 5|base of phalanx of little finger|proximal epiphysis of phalanx of manual digit V|base of phalanx of fifth finger|proximal epiphysis of phalanx of little finger	http://purl.obolibrary.org/obo/UBERON_0004421		
GO:0007409	biolink:BiologicalProcess	axonogenesis	De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.		hp.json	axon growth|axon morphogenesis|neuron long process generation	http://purl.obolibrary.org/obo/GO_0007409		
GO:0007407	biolink:BiologicalProcess	neuroblast activation	A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.		hp.json		http://purl.obolibrary.org/obo/GO_0007407		
GO:0007406	biolink:BiologicalProcess	negative regulation of neuroblast proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.		hp.json	down-regulation of neuroblast proliferation|suppression of neuroblast proliferation|downregulation of neuroblast proliferation|down regulation of neuroblast proliferation|inhibition of neuroblast proliferation	http://purl.obolibrary.org/obo/GO_0007406		
GO:0007405	biolink:BiologicalProcess	neuroblast proliferation	The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.		hp.json		http://purl.obolibrary.org/obo/GO_0007405		
UBERON:0004408	biolink:AnatomicalEntity	distal epiphysis of ulna	A distal epiphysis that is part of a ulna [Automatically generated definition].	FMA:33754	hp.json	distal end of ulna|lower end of ulna	http://purl.obolibrary.org/obo/UBERON_0004408		pheno_slim
UBERON:0004409	biolink:AnatomicalEntity	distal epiphysis of phalanx of manus	A distal epiphysis that is part of a phalanx of manus [Automatically generated definition].	FMA:226577	hp.json	ungual tuberosity of distal phalanx of finger|distal epiphysis of phalanx of hand|distal end of phalanx of hand|distal epiphysis of phalanx of finger|head of phalanx of hand|head of phalanx of finger	http://purl.obolibrary.org/obo/UBERON_0004409		
UBERON:0004406	biolink:AnatomicalEntity	distal epiphysis of femur	A distal epiphysis that is part of a femur [Automatically generated definition].	FMA:32844|AAO:0000893	hp.json	distal head of femur|distal femoral epiphysis	http://purl.obolibrary.org/obo/UBERON_0004406		pheno_slim
UBERON:0004407	biolink:AnatomicalEntity	distal epiphysis of radius	A distal epiphysis that is part of a radius [Automatically generated definition].	FMA:33776	hp.json	distal end of radius|lower end of radius	http://purl.obolibrary.org/obo/UBERON_0004407		pheno_slim
CHEBI:45696	biolink:ChemicalSubstance	hydrogensulfate		Gmelin:2121	hp.json	HSO4(-)|hydrogentetraoxosulfate(VI)|hydroxidotrioxidosulfate(1-)|hydrogensulfate(1-)|hydrogensulfate|[SO3(OH)](-)|hydrogen(tetraoxidosulfate)(1-)|HYDROGEN SULFATE|hydrogentetraoxosulfate(1-)	http://purl.obolibrary.org/obo/CHEBI_45696		3_STAR
PATO:0002154	biolink:NamedThing	splayed ventral	A curvature quality inhering in a bearer by virtue of the bearer's being curved outwards the abdomen of an organism.		hp.json	splayed inferior (human head)|splayed anterior (human torso)	http://purl.obolibrary.org/obo/PATO_0002154		value_slim
CHEBI:57670	biolink:ChemicalSubstance	N-acylglycinate	A carboxylic acid anion obtained by deprotonation of the carboxy group of any N-acylglycine.		hp.json	an N-acylglycine	http://purl.obolibrary.org/obo/CHEBI_57670		3_STAR
PATO:0002157	biolink:NamedThing	partially dislocated	A positional quality inhering in a bearer by virtue of the bearer's being slightly out of its usual or proper place, or position.		hp.json	subluxation|partial dislocated towards|suluxated towards	http://purl.obolibrary.org/obo/PATO_0002157		value_slim|relational_slim
PATO:0002155	biolink:NamedThing	medially rotated	A rotation quality inhering in a bearer by virtue of being rotated towards the middle of an organism.		hp.json	internally rotated	http://purl.obolibrary.org/obo/PATO_0002155		mpath_slim|value_slim
PATO:0002156	biolink:NamedThing	laterally rotated	A rotation quality inhering in a bearer by virtue of being rotated towards the side of an organism.		hp.json	externally rotated	http://purl.obolibrary.org/obo/PATO_0002156		value_slim|mpath_slim
UBERON:0004415	biolink:AnatomicalEntity	proximal epiphysis of metatarsal bone	A proximal epiphysis that is part of a metatarsal bone [Automatically generated definition].	FMA:33817	hp.json	basis ossis metatarsi|upper end of metatarsal bone|base of metatarsal bone|proximal end of metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004415		
UBERON:0004416	biolink:AnatomicalEntity	proximal epiphysis of metacarpal bone	A proximal epiphysis that is part of a metacarpal bone [Automatically generated definition].	FMA:33795	hp.json	proximal end of metacarpal bone|metacarpal bone base|basis ossis metacarpi|upper end of metacarpal bone|base of metacarpal bone	http://purl.obolibrary.org/obo/UBERON_0004416		
UBERON:0004413	biolink:AnatomicalEntity	proximal epiphysis of radius	A proximal epiphysis that is part of a radius [Automatically generated definition].	FMA:39780	hp.json	upper end of radius|proximal radial epiphysis|proximal end of radius	http://purl.obolibrary.org/obo/UBERON_0004413		pheno_slim
UBERON:0004414	biolink:AnatomicalEntity	proximal epiphysis of phalanx of manus	A proximal epiphysis that is part of a phalanx of manus [Automatically generated definition].	FMA:226482	hp.json	proximal epiphysis of phalanx of hand|basis phalangis manus|basal epiphysis of phalanx of finger|proximal epiphysis of phalanx of finger|base of phalanx of finger	http://purl.obolibrary.org/obo/UBERON_0004414		
UBERON:0004411	biolink:AnatomicalEntity	proximal epiphysis of humerus	The upper extremity of the humerus (proximal humerus) consists of a large rounded head joined to the body by a constricted portion called the neck, and two eminences, the greater and lesser tubercles.	FMA:23362	hp.json	proximal humeral epiphysis|proximal humerus|head of the humerus|proximal end of humerus|upper extremity of humerus|humeral head|upper end of humerus	http://purl.obolibrary.org/obo/UBERON_0004411		pheno_slim
UBERON:0004412	biolink:AnatomicalEntity	proximal epiphysis of femur	A proximal epiphysis that is part of a femur [Automatically generated definition].	FMA:32841	hp.json	capital femoral epiphysis|proximal femoral epiphysis	http://purl.obolibrary.org/obo/UBERON_0004412		pheno_slim
UBERON:0004410	biolink:AnatomicalEntity	distal epiphysis of fibula	A distal epiphysis that is part of a fibula [Automatically generated definition].	FMA:33732	hp.json	distal end of fibula|lower end of fibula	http://purl.obolibrary.org/obo/UBERON_0004410		pheno_slim
CHEBI:33693	biolink:ChemicalSubstance	oxygen hydride			hp.json	hydrides of oxygen|oxygen hydride|oxygen hydrides	http://purl.obolibrary.org/obo/CHEBI_33693		3_STAR
PATO:0002165	biolink:NamedThing	drooping	To bent or hang downwards.		hp.json	sagging	http://purl.obolibrary.org/obo/PATO_0002165		value_slim
CHEBI:33694	biolink:ChemicalSubstance	biomacromolecule	A macromolecule formed by a living organism.		hp.json	Biopolymere|biopolymers|biomacromolecules|biopolymer	http://purl.obolibrary.org/obo/CHEBI_33694		3_STAR
CHEBI:33695	biolink:ChemicalSubstance	information biomacromolecule			hp.json	information macromolecules|information biomacromolecules|information macromolecule|genetically encoded biopolymers|information biopolymers|genetically encoded biomacromolecules	http://purl.obolibrary.org/obo/CHEBI_33695		3_STAR
PATO:0002162	biolink:NamedThing	high-arched	A concave quality inhering in a bearer by virtue of the bearer's forming or resembling an arch of an increased apical height.		hp.json		http://purl.obolibrary.org/obo/PATO_0002162		value_slim
CHEBI:33696	biolink:ChemicalSubstance	nucleic acid	A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.		hp.json	nucleic acids|acide nucleique|acidos nucleicos|Nukleinsaeure|NA|acido nucleico|acides nucleiques|Nukleinsaeuren	http://purl.obolibrary.org/obo/CHEBI_33696		3_STAR
PATO:0002163	biolink:NamedThing	herniated into	A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it into the surface or boundary of another entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0002163		mpath_slim|relational_slim|value_slim
CHEBI:33697	biolink:ChemicalSubstance	ribonucleic acid	High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.	CAS:63231-63-0	hp.json	ribose nucleic acid|ribonucleic acid|yeast nucleic acid|RNS|RNA|RNA|pentosenucleic acids|ribonucleic acids|ribonucleic acids|Ribonukleinsaeure	http://purl.obolibrary.org/obo/CHEBI_33697		3_STAR
PATO:0002169	biolink:NamedThing	split medially	A shape quality inhering in a bearer by virtue of the bearer's being split along the median axis.		hp.json		http://purl.obolibrary.org/obo/PATO_0002169		value_slim
PATO:0002166	biolink:NamedThing	premature closure	A duration quality of a process inhering in a bearer by virtue of the bearer's premature completion of the closure of the opening of an anatomical entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0002166		value_slim
UBERON:0004404	biolink:AnatomicalEntity	distal epiphysis of humerus	A distal epiphysis that is part of a humerus [Automatically generated definition].	FMA:32826	hp.json	distal end of humerus|lower end of humerus	http://purl.obolibrary.org/obo/UBERON_0004404		pheno_slim
UBERON:0004405	biolink:AnatomicalEntity	distal epiphysis of tibia	A distal epiphysis that is part of a tibia [Automatically generated definition].	FMA:33116	hp.json	distal end of tibia|lower end of tibia	http://purl.obolibrary.org/obo/UBERON_0004405		pheno_slim
UBERON:0004402	biolink:AnatomicalEntity	bone tissue of proximal epiphysis	A portion of bone tissue that is part of a proximal epiphysis [Automatically generated definition].	FMA:241372	hp.json		http://purl.obolibrary.org/obo/UBERON_0004402		
UBERON:0004403	biolink:AnatomicalEntity	periosteum of epiphysis	A periosteum that is part of a epiphysis [Automatically generated definition].	FMA:32687	hp.json	epiphysis periosteum	http://purl.obolibrary.org/obo/UBERON_0004403		
UBERON:0004400	biolink:AnatomicalEntity	bone tissue of epiphysis	A portion of bone tissue that is part of a epiphysis [Automatically generated definition].	FMA:241364	hp.json		http://purl.obolibrary.org/obo/UBERON_0004400		
UBERON:0004401	biolink:AnatomicalEntity	bone tissue of distal epiphysis	A portion of bone tissue that is part of a distal epiphysis [Automatically generated definition].	FMA:241374	hp.json		http://purl.obolibrary.org/obo/UBERON_0004401		
PATO:0002161	biolink:NamedThing	bicornuate	Having two horns or horn-shaped branches.		hp.json		http://purl.obolibrary.org/obo/PATO_0002161		value_slim
CHEBI:33692	biolink:ChemicalSubstance	hydrides	Hydrides are chemical compounds of hydrogen with other chemical elements.		hp.json		http://purl.obolibrary.org/obo/CHEBI_33692		3_STAR
CHEBI:18095	biolink:ChemicalSubstance	trans-4-hydroxy-L-proline	An optically active form of 4-hydroxyproline having L-trans-configuration.	PMID:17021603|PMID:590925|PMID:16096557|PMID:6783274|PMID:12148113|MetaCyc:4-HYDROXY-L-PROLINE|CAS:51-35-4|PMID:7283558|Drug_Central:4272|PMID:7446210|PMID:14995121|PDBeChem:HYP|PMID:1117843|PMID:7248905|PMID:1166829|PMID:15558350|CAS:51-35-4|PMID:899882|CAS:51-35-4|PMID:14104082|PMID:16665943|PMID:616023|PMID:946341|PMID:16662024|HMDB:HMDB0000725|PMID:16656634|Reaxys:81441|KEGG:C01157|PMID:19286848|PMID:6625779|PMID:6616407|KNApSAcK:C00001370	hp.json	Hydroxyproline|(2S,4R)-trans-4-hydroxyproline|(4R)-4-hydroxy-L-proline|Hypro|trans-4-Hydroxy-L-proline|Hyp|L-4-Hydroxyproline|(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid|L-threo-4-hydroxyproline|trans-L-Hydroxyproline|trans-Hydroxyproline|delta-hydroxyproline|trans-4-hydroxy-L-proline|Hydroxy-L-proline	http://purl.obolibrary.org/obo/CHEBI_18095		3_STAR
PATO:0002175	biolink:NamedThing	deviation	A spatial quality inhering in a bearer by virtue of the bearer's changed direction of position towards another entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0002175		attribute_slim
PATO:0002176	biolink:NamedThing	deviation towards the lateral side	A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the side.		hp.json		http://purl.obolibrary.org/obo/PATO_0002176		value_slim
PATO:0002179	biolink:NamedThing	mislocalised proximally	A positional quality inhering in a bearer by virtue of the bearer's being positioned towards to point of attachment or origin.		hp.json		http://purl.obolibrary.org/obo/PATO_0002179		value_slim
PATO:0002177	biolink:NamedThing	deviation towards the medial side	A deviation quality inhering in a bearer by virtue of the bearer's changed direction of position towards the middle.		hp.json		http://purl.obolibrary.org/obo/PATO_0002177		value_slim
NCBITaxon:8457	biolink:OrganismalEntity	Sauropsida		GC_ID:1	hp.json	sauropsids	http://purl.obolibrary.org/obo/NCBITaxon_8457		
CHEBI:18089	biolink:ChemicalSubstance	N-benzoylglycine	An N-acylglycine in which the acyl group is specified as benzoyl.	MetaCyc:CPD-425|KEGG:C01586|PMID:16760132|CAS:495-69-2|PMID:19891605|PMID:17190852|CAS:495-69-2|CAS:495-69-2|PMID:19283696|PMID:9120876|PMID:9609721|PMID:14646363|PMID:15879000|PMID:8734460|PMID:7153346|Reaxys:1073987|KNApSAcK:C00030483|Wikipedia:Hippuric_acid|PMID:20405919|HMDB:HMDB0000714|PMID:22770225	hp.json	N-Benzoylglycine|Hippursaeure|N-benzoylglycine|Benzamidoessigsaeure|N-benzoylglycine|Benzoylaminoessigsaeure|Benzoylaminoacetic acid|Benzamidoacetic acid|Phenylcarbonylaminoacetic acid|Hippuric acid|Hippurate	http://purl.obolibrary.org/obo/CHEBI_18089		3_STAR
CHEBI:57652	biolink:ChemicalSubstance	chondroitin D-glucuronate anion	Anionic form of chondroitin D-glucuronate arising from deprotonation of the carboxylic acid groups of the repeating units; major species at pH 7.3.		hp.json	chondroitin D-glucuronate|chondroitin D-glucuronate polyanion	http://purl.obolibrary.org/obo/CHEBI_57652		3_STAR
UBERON:0016440	biolink:AnatomicalEntity	glabella region of bone	A zone of the frontal bone that connects the supraorbital rirdges.	FMA:52851|FMA:57136	hp.json	glabellar surface of frontal bone|glabella	http://purl.obolibrary.org/obo/UBERON_0016440		pheno_slim
UBERON:0016442	biolink:AnatomicalEntity	median palatine suture	The line of junction between the horizontal parts of the palatine bones that extends from both sides of the skull to form the posterior part of the hard palate.	FMA:52966	hp.json	median palatine suture of skull|midpalatal suture of skull|middle palatine suture of skull	http://purl.obolibrary.org/obo/UBERON_0016442		pheno_slim
UBERON:0016447	biolink:AnatomicalEntity	hair of trunk	A strand of hair that is part of a trunk.	FMA:54250	hp.json	trunk hair	http://purl.obolibrary.org/obo/UBERON_0016447		pheno_slim
UBERON:0016446	biolink:AnatomicalEntity	hair of head	A strand of hair that is part of a head.	FMA:54241	hp.json	hair of scalp|head hair	http://purl.obolibrary.org/obo/UBERON_0016446		pheno_slim
UBERON:0004462	biolink:AnatomicalEntity	musculature of body wall	Any collection of muscles that is part of a body wall [Automatically generated definition].	BSA:0000058|FMA:86931|EMAPA:37853|WBbt:0005813|BTO:0001863	hp.json	body wall musculature|body wall muscles	http://purl.obolibrary.org/obo/UBERON_0004462		
CHEBI:33671	biolink:ChemicalSubstance	heteropolycyclic compound	A polycyclic compound in which at least one of the rings contains at least one non-carbon atom.		hp.json	polyheterocyclic compounds|heteropolycyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33671		3_STAR
UBERON:0004463	biolink:AnatomicalEntity	musculature of hindlimb stylopod	Any collection of muscles that is part of a hindlimb stylopod (upper leg / thigh)[Automatically generated definition].	FMA:50208	hp.json	thigh musculature|musculature of thigh|set of muscles of thigh|muscle group of thigh	http://purl.obolibrary.org/obo/UBERON_0004463		pheno_slim
CHEBI:33672	biolink:ChemicalSubstance	heterobicyclic compound	A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom.		hp.json	heterobicyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33672		3_STAR
HP:0004510	biolink:PhenotypicFeature	Pancreatic islet-cell hyperplasia	Hyperplasia of the islets of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells.	UMLS:C0597167	hp.json	Islet of Langerhans hyperplasia|Pancreatic islet-cell hypertrophy|Hypertrophic pancreatic islets|Islets of langerhans hypertrophy|Hyperplastic islets of langerhans	http://purl.obolibrary.org/obo/HP_0004510		
UBERON:0004461	biolink:AnatomicalEntity	skeletal musculature of head	Any collection of skeletal muscles that is part of a head [Automatically generated definition].	FMA:71287|EMAPA:18171	hp.json	set of muscles of head|muscles of head|muscle group of head|musculi capitis|head musculature	http://purl.obolibrary.org/obo/UBERON_0004461		non_informative
CHEBI:33674	biolink:ChemicalSubstance	s-block molecular entity	An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element.		hp.json	s-block molecular entity|s-block molecular entities|s-block compounds	http://purl.obolibrary.org/obo/CHEBI_33674		3_STAR
CHEBI:33675	biolink:ChemicalSubstance	p-block molecular entity	A main group molecular entity that contains one or more atoms of a p-block element.		hp.json	p-block compounds|p-block molecular entitiy|p-block molecular entities	http://purl.obolibrary.org/obo/CHEBI_33675		3_STAR
CHEBI:33676	biolink:ChemicalSubstance	d-block molecular entity	A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element.		hp.json	d-block molecular entity|d-block molecular entities|d-block compounds	http://purl.obolibrary.org/obo/CHEBI_33676		3_STAR
UBERON:0004468	biolink:AnatomicalEntity	set of muscles of vertebral column		FMA:33061	hp.json	muscle group of vertebral column	http://purl.obolibrary.org/obo/UBERON_0004468		
UBERON:0004469	biolink:AnatomicalEntity	musculature of back	Any collection of muscles that is part of a back [Automatically generated definition].	FMA:71291	hp.json	muscle group of back|musculi dorsi|set of muscles of back|muscles of back	http://purl.obolibrary.org/obo/UBERON_0004469		
UBERON:0004466	biolink:AnatomicalEntity	musculature of leg	Any collection of muscles that is part of a lower leg or upper leg [Automatically generated definition].	EHDAA2:0000973	hp.json	leg muscle system	http://purl.obolibrary.org/obo/UBERON_0004466		
CHEBI:31011	biolink:ChemicalSubstance	valerate	A short-chain fatty acid anion that is the conjugate base of valeric acid; present in ester form as component of many steroid-based pharmaceuticals.	PMID:17314444|Gmelin:325619|PMID:18783570|Beilstein:3903735|Reaxys:3903735|CAS:10023-74-2	hp.json	pentanoate|CH3-[CH2]3-COO(-)|pentanoic acid, ion(1-)|pentanoate|n-propylacetate	http://purl.obolibrary.org/obo/CHEBI_31011		3_STAR
UBERON:0004467	biolink:AnatomicalEntity	musculature of pharynx	The collection of muscles that acts on the pharynx.	FMA:264609|ZFA:0001307|TAO:0001307	hp.json	pharyngeal musculature|set of muscles of pharynx	http://purl.obolibrary.org/obo/UBERON_0004467		vertebrate_core
UBERON:0004464	biolink:AnatomicalEntity	musculature of thorax	Any collection of muscles that is part of a thorax [Automatically generated definition].	FMA:71293|BTO:0000508|EMAPA:37260	hp.json	musculi thoracis|set of muscles of thorax|thoracic musculature|muscles of thorax|muscle group of thorax	http://purl.obolibrary.org/obo/UBERON_0004464		pheno_slim
UBERON:0004465	biolink:AnatomicalEntity	musculature of neck	Any collection of muscles that is part of a neck [Automatically generated definition].	AAO:0000091|EMAPA:36050|MESH:D009334|FMA:71290	hp.json	musculi colli|muscles of neck|muscle group of neck|musculi cervicis|neck musculature|set of muscles of neck|cervical muscles	http://purl.obolibrary.org/obo/UBERON_0004465		pheno_slim
CHEBI:33670	biolink:ChemicalSubstance	heteromonocyclic compound			hp.json	heteromonocyclic compound|heteromonocyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33670		3_STAR
UBERON:0016430	biolink:AnatomicalEntity	palmar branch of median nerve	The palmar branch of the median nerve is a branch of the median nerve which arises at the lower part of the forearm and innervates skin of proximal central palm and thenar eminence.	FMA:44836	hp.json	ramus palmaris nervus interossei antebrachii anterior|palmar branch of anterior interosseous nerve|ramus palmaris (nervus medianus)|palmar cutaneous branch of median nerve|median nerve palmar branch	http://purl.obolibrary.org/obo/UBERON_0016430		pheno_slim
PATO:0002118	biolink:NamedThing	multiple	A quality inhering in a bearer by virtue of the bearer's being present in more than two copies.		hp.json		http://purl.obolibrary.org/obo/PATO_0002118		value_slim|mpath_slim
HP:0004529	biolink:PhenotypicFeature	Atrophic, patchy alopecia		UMLS:C4025314	hp.json		http://purl.obolibrary.org/obo/HP_0004529		
HP:0004528	biolink:PhenotypicFeature	Generalized hypotrichosis	Reduced or lacking hair growth in a generalized distribution.	UMLS:C4021653	hp.json	Hypotrichosis, generalized|Hypotrichosis, generalised|Generalised hypotrichosis	http://purl.obolibrary.org/obo/HP_0004528		
UBERON:0016435	biolink:AnatomicalEntity	chest wall	Subdivision of thorax which includes all structures from the skin to the costal pleura. Examples: There is only one chest wall.	FMA:50060|NCIT:C62484|EMAPA:37233	hp.json		http://purl.obolibrary.org/obo/UBERON_0016435		pheno_slim
UBERON:0004451	biolink:AnatomicalEntity	trunk or cervical vertebra	A vertebra in the trunk or cervical region. Includes all cervical, thoracic and lumbar vertebrae, but excludes caudal vertebra.	XAO:0003077|EMAPA:37722|MA:0002869	hp.json	presacral vertebra	http://purl.obolibrary.org/obo/UBERON_0004451		pheno_slim
HP:0004523	biolink:PhenotypicFeature	Long eyebrows	Increased length of the hairs of the eyebrows.	UMLS:C3280131	hp.json	Increased horizontal length of eyebrow|Long eyebrows|Elongated eyebrow|Increased transverse length of eyebrow	http://purl.obolibrary.org/obo/HP_0004523		
UBERON:0004452	biolink:AnatomicalEntity	carpal region	A mesopodium that is part of a manus. Includes as parts the carpal skeleton and associated tissues[cjm]. The anatomical region surrounding the carpus including the distal parts of the bones of the forearm and the proximal parts of the metacarpus or five metacarpal bones and the series of joints between these bones, thus referred to as wrist joints. This region also includes the carpal tunnel, the anatomical snuff box, the flexor retinaculum, and the extensor retinaculum[WP,unvetted].	MESH:D014953|EMAPA:19122|GAID:59|NCIT:C111033|FMA:24922|EMAPA:32784|OpenCyc:Mx4rvVjncpwpEbGdrcN5Y29ycA|EHDAA:5196|EHDAA2:0000218|MA:0000039|galen:Wrist	hp.json	carpus|carpal limb segment|fore basipodium|fore mesopodium|carpal segment|regio carpalis|manus mesopodium|carpus of fore-paw|articulatio radiocarpea|wrist region|wrist|hand mesopodium	http://purl.obolibrary.org/obo/UBERON_0004452		pheno_slim|uberon_slim
HP:0004527	biolink:PhenotypicFeature	Large clumps of pigment irregularly distributed along hair shaft		UMLS:C4025315	hp.json	Large clumps of pigment irregularly distributed along hair shaft	http://purl.obolibrary.org/obo/HP_0004527		
PATO:0002112	biolink:NamedThing	perforate	A structural quality inhering in a bearer by virtue of the bearer's having a hole or holes, especially a row or array of small holes.		hp.json	permeable|pierced	http://purl.obolibrary.org/obo/PATO_0002112		value_slim|mpath_slim
HP:0004524	biolink:PhenotypicFeature	Temporal hypotrichosis	Reduced or lacking hair growth in the temporal region (i.e., around the temples on the side of the skull).	UMLS:C4025316	hp.json	Reduced hair growth in temporal region	http://purl.obolibrary.org/obo/HP_0004524		
UBERON:0004455	biolink:AnatomicalEntity	neurula embryo	An embryo at the neurula stage.	NCIT:C34229|BILA:0000061|BTO:0001766|UMLS:C1518306	hp.json	neurula	http://purl.obolibrary.org/obo/UBERON_0004455		
UBERON:0004456	biolink:AnatomicalEntity	entire sense organ system	Sum of all sensory systems in an organism.	FMA:78499	hp.json	sense organ system	http://purl.obolibrary.org/obo/UBERON_0004456		uberon_slim
UBERON:0004453	biolink:AnatomicalEntity	metacarpus region	A metapodium region that is part of a manus.	FMA:24925|MA:0000042|EMAPA:32654|CALOHA:TS-2218	hp.json	metacarpal region|distal segment of hand proper|metacarpus|metacarpal part of manus|metacarpal part of hand|forelimb cannon region|forelimb equine cannon region	http://purl.obolibrary.org/obo/UBERON_0004453		pheno_slim
UBERON:0004454	biolink:AnatomicalEntity	tarsal region	Mesopodial segment of the pes, including the tarsal skeleton and associated tissues.	EFO:0001409|MESH:D000842|FMA:9665|MA:0000043|OpenCyc:Mx4rvVi-R5wpEbGdrcN5Y29ycA|galen:Ankle|CALOHA:TS-2219|EMAPA:32783|GAID:41	hp.json	ankle|hind basipodium|ankle region|tarsal limb segment|hock|hind mesopodium|articulatio talocruralis	http://purl.obolibrary.org/obo/UBERON_0004454		pheno_slim|efo_slim|uberon_slim
CHEBI:57630	biolink:ChemicalSubstance	gamma-amino-beta-hydroxybutyric acid zwitterion	Zwitterionic form of gamma-amino-beta-hydroxybutyric acid having an anionic carboxy group and a protonated amino group.		hp.json	4-ammonio-3-hydroxybutanoate|4-azaniumyl-3-hydroxybutanoate|4-amino-3-hydroxybutanoate	http://purl.obolibrary.org/obo/CHEBI_57630		3_STAR
UBERON:0004439	biolink:AnatomicalEntity	proximal epiphysis of middle phalanx of manual digit 5	A proximal epiphysis that is part of a middle phalanx of manual digit 5 [Automatically generated definition].	FMA:37538	hp.json	basal epiphysis of middle phalanx of little finger|basal epiphysis of middle phalanx of fifth finger|proximal epiphysis of middle phalanx of little finger|base of middle phalanx of little finger|base of middle phalanx of fifth finger|proximal epiphysis of middle phalanx of manual digit V|base of middle phalanx of fifth digit of hand	http://purl.obolibrary.org/obo/UBERON_0004439		
UBERON:0016426	biolink:AnatomicalEntity	proximal interphalangeal joint of little finger		FMA:35324	hp.json		http://purl.obolibrary.org/obo/UBERON_0016426		pheno_slim
CHEBI:33658	biolink:ChemicalSubstance	arene	Any monocyclic or polycyclic aromatic hydrocarbon.		hp.json	arene|aromatic hydrocarbons|arenes	http://purl.obolibrary.org/obo/CHEBI_33658		3_STAR
UBERON:0016425	biolink:AnatomicalEntity	epiphyseal plate of radius	An epiphyseal plate that is part of a radius bone.	FMA:34354	hp.json		http://purl.obolibrary.org/obo/UBERON_0016425		pheno_slim
CHEBI:33659	biolink:ChemicalSubstance	organic aromatic compound			hp.json	organic aromatic compounds	http://purl.obolibrary.org/obo/CHEBI_33659		3_STAR
UBERON:0016422	biolink:AnatomicalEntity	compact bone of long bone	A compact bone tissue that is part of a bone tissue of long bone.	FMA:32674	hp.json		http://purl.obolibrary.org/obo/UBERON_0016422		pheno_slim
UBERON:0016423	biolink:AnatomicalEntity	compact bone of diaphysis	A compact bone tissue that is part of a diaphysis.	FMA:32678	hp.json		http://purl.obolibrary.org/obo/UBERON_0016423		pheno_slim
UBERON:0004440	biolink:AnatomicalEntity	proximal epiphysis of proximal phalanx of manual digit 2	A proximal epiphysis that is part of a proximal phalanx of manual digit 2 [Automatically generated definition].	FMA:37499	hp.json	base of proximal phalanx of second digit of hand|base of proximal phalanx of index finger|proximal epiphysis of proximal phalanx of index finger|base of proximal phalanx of second finger|proximal epiphysis of proximal phalanx of manual digit II	http://purl.obolibrary.org/obo/UBERON_0004440		
UBERON:0004441	biolink:AnatomicalEntity	proximal epiphysis of proximal phalanx of manual digit 3	A proximal epiphysis that is part of a proximal phalanx of manual digit 3 [Automatically generated definition].	FMA:37511	hp.json	proximal epiphysis of proximal phalanx of manual digit III|base of proximal phalanx of middle finger|base of proximal phalanx of third finger|base of proximal phalanx of third digit of hand|basal epiphysis of proximal phalanx of middle finger|proximal epiphysis of proximal phalanx of middle finger	http://purl.obolibrary.org/obo/UBERON_0004441		
PATO:0002124	biolink:NamedThing	laminar	A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer.		hp.json		http://purl.obolibrary.org/obo/PATO_0002124		value_slim|mpath_slim
UBERON:0016419	biolink:AnatomicalEntity	bony part of vertebral arch		FMA:29741	hp.json	bony part of arch of vertebra	http://purl.obolibrary.org/obo/UBERON_0016419		
CHEBI:33653	biolink:ChemicalSubstance	aliphatic compound	Any acyclic or cyclic, saturated or unsaturated carbon compound, excluding aromatic compounds.		hp.json	aliphatic compounds	http://purl.obolibrary.org/obo/CHEBI_33653		3_STAR
UBERON:0016418	biolink:AnatomicalEntity	nasion	The intersection of the frontal and two nasal bones of the human skull. Its manifestation on the visible surface of the face is a distinctly depressed area directly between the eyes, just superior to the bridge of the nose.	FMA:264779	hp.json		http://purl.obolibrary.org/obo/UBERON_0016418		pheno_slim
CHEBI:33655	biolink:ChemicalSubstance	aromatic compound	A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character.		hp.json	aromatic molecular entity|aromatics|aromatic compounds|aromatische Verbindungen	http://purl.obolibrary.org/obo/CHEBI_33655		3_STAR
UBERON:0004448	biolink:AnatomicalEntity	distal epiphysis of phalanx	A distal epiphysis that is part of a phalanx [Automatically generated definition].		hp.json	head of phalanx	http://purl.obolibrary.org/obo/UBERON_0004448		
UBERON:0004449	biolink:AnatomicalEntity	cerebral artery	One of three main pairs of arteries and their branches, which irrigate the cerebrum of the brain.	AAO:0010493|NCIT:C12691|CALOHA:TS-0126|EHDAA:5294|EMAPA:18613|XAO:0000367|UMLS:C0007770|MESH:D002536|SCTID:181308008|GAID:484|MA:0002562|EHDAA2:0000233|Wikipedia:Cerebral_artery|BTO:0005205	hp.json		http://purl.obolibrary.org/obo/UBERON_0004449		pheno_slim
UBERON:0004446	biolink:AnatomicalEntity	epiphysis of phalanx	An epiphysis that is part of a phalanx [Automatically generated definition].		hp.json		http://purl.obolibrary.org/obo/UBERON_0004446		pheno_slim
CHEBI:18059	biolink:ChemicalSubstance	lipid	'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids.	KEGG:C01356	hp.json	Lipid|lipids	http://purl.obolibrary.org/obo/CHEBI_18059		3_STAR
UBERON:0004447	biolink:AnatomicalEntity	proximal epiphysis of phalanx	A proximal epiphysis that is part of a phalanx [Automatically generated definition].		hp.json		http://purl.obolibrary.org/obo/UBERON_0004447		
UBERON:0004444	biolink:AnatomicalEntity	proximal epiphysis of distal phalanx of manual digit 1	A proximal epiphysis that is part of a distal phalanx of manual digit 1 [Automatically generated definition].	FMA:37493	hp.json	base of distal phalanx of thumb|proximal epiphysis of distal phalanx of manual digit I|proximal epiphysis of distal phalanx of thumb	http://purl.obolibrary.org/obo/UBERON_0004444		
UBERON:0004445	biolink:AnatomicalEntity	proximal epiphysis of proximal phalanx of manual digit 1	A proximal epiphysis that is part of a proximal phalanx of manual digit 1 [Automatically generated definition].	FMA:37490	hp.json	basal epiphysis of proximal phalanx of thumb|proximal epiphysis of proximal phalanx of thumb|proximal epiphysis of proximal phalanx of manual digit I|base of proximal phalanx of thumb	http://purl.obolibrary.org/obo/UBERON_0004445		
UBERON:0004442	biolink:AnatomicalEntity	proximal epiphysis of proximal phalanx of manual digit 4	A proximal epiphysis that is part of a proximal phalanx of manual digit 4 [Automatically generated definition].	FMA:37523	hp.json	basal epiphysis of proximal phalanx of fourth finger|proximal epiphysis of proximal phalanx of manual digit IV|basal epiphysis of proximal phalanx of ring finger|base of proximal phalanx of fourth finger|proximal epiphysis of proximal phalanx of ring finger|base of proximal phalanx of ring finger|base of proximal phalanx of fourth digit of hand	http://purl.obolibrary.org/obo/UBERON_0004442		
UBERON:0004443	biolink:AnatomicalEntity	proximal epiphysis of proximal phalanx of manual digit 5	A proximal epiphysis that is part of a proximal phalanx of manual digit 5 [Automatically generated definition].	FMA:37535	hp.json	proximal epiphysis of proximal phalanx of little finger|proximal epiphysis of proximal phalanx of manual digit V|base of proximal phalanx of little finger|base of proximal phalanx of fifth digit of hand|base of proximal phalanx of fifth finger|basal epiphysis of proximal phalanx of little finger	http://purl.obolibrary.org/obo/UBERON_0004443		
UBERON:0004428	biolink:AnatomicalEntity	proximal epiphysis of second metatarsal bone	A proximal epiphysis that is part of a metatarsal bone of digit 2 [Automatically generated definition].	FMA:42964	hp.json	proximal end of second metatarsal bone|proximal epiphysis of metatarsal 2|base of second metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004428		
UBERON:0004429	biolink:AnatomicalEntity	proximal epiphysis of third metatarsal bone	A proximal epiphysis that is part of a metatarsal bone of digit 3 [Automatically generated definition].	FMA:42965	hp.json	proximal end of third metatarsal bone|proximal epiphysis of metatarsal 3|base of third metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004429		
UBERON:0016416	biolink:AnatomicalEntity	anterior chest	Subdivision of thorax which is anterior to the plane of the posterior boundary of the middle mediastinum.	FMA:24816	hp.json	front of chest|ventral chest|anterior thoracic region	http://purl.obolibrary.org/obo/UBERON_0016416		pheno_slim
CHEBI:45630	biolink:ChemicalSubstance	4-oxopentanoic acid	An oxopentanoic acid with the oxo group in the 4-position.	CAS:123-76-2|PMID:23627123|Gmelin:164703|PMID:13215009|PMID:16662002|LIPID_MAPS_instance:LMFA01060006|Beilstein:506796|Wikipedia:Levulinic_acid|HMDB:HMDB0000720|Reaxys:506796|PDBeChem:SHF|DrugBank:DB02239|PMID:19246769|CAS:123-76-2	hp.json	3-ketobutane-1-carboxylic acid|Levulinsaeure|4-oxopentanoic acid|4-oxovaleric acid|LEVA|gamma-ketovaleric acid|4-ketovaleric acid|beta-acetylpropionic acid|LAEVULINIC ACID|Laevulinsaeure|3-acetylpropionic acid|gamma-ketovaleric acid|levulic acid|levulinic acid	http://purl.obolibrary.org/obo/CHEBI_45630		3_STAR
UBERON:0016410	biolink:AnatomicalEntity	male breast	A breast that is part of a male organism.	FMA:19901|NCIT:C33048	hp.json	mamma masculina	http://purl.obolibrary.org/obo/UBERON_0016410		pheno_slim
UBERON:0016413	biolink:AnatomicalEntity	medullary cavity of long bone		FMA:24023	hp.json	central medullary cavity of long bone	http://purl.obolibrary.org/obo/UBERON_0016413		pheno_slim
UBERON:0016412	biolink:AnatomicalEntity	central part of body of bony vertebral centrum		FMA:24003	hp.json	central part of body of vertebra	http://purl.obolibrary.org/obo/UBERON_0016412		pheno_slim
UBERON:0004430	biolink:AnatomicalEntity	proximal epiphysis of fourth metatarsal bone	A proximal epiphysis that is part of a metatarsal bone of digit 4 [Automatically generated definition].	FMA:42966	hp.json	base of fourth metatarsal bone|proximal epiphysis of metatarsal 4|proximal end of fourth metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004430		
CHEBI:33661	biolink:ChemicalSubstance	monocyclic compound			hp.json	monocyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33661		3_STAR
NCBITaxon:8492	biolink:OrganismalEntity	Archosauria		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_8492		
CHEBI:33662	biolink:ChemicalSubstance	annulene	A mancude monocyclic hydrocarbon without side chains of the general formula CnHn (n is an even number) or CnHn+1 (n is an odd number). In systematic nomenclature an annulene with seven or more carbon atoms may be named [n]annulene, where n is the number of carbon atoms.		hp.json	annulene|annulenes	http://purl.obolibrary.org/obo/CHEBI_33662		3_STAR
CHEBI:33663	biolink:ChemicalSubstance	cyclic hydrocarbon			hp.json	cyclic hydrocarbon|cyclic hydrocarbons	http://purl.obolibrary.org/obo/CHEBI_33663		3_STAR
UBERON:0016408	biolink:AnatomicalEntity	corona of glans penis	The circumference of the base of the glans forms a rounded projecting border, the corona of the glans penis, overhanging a deep retroglandular sulcus, behind which is the neck of the penis.	FMA:19627	hp.json	glans corona|corona glandis|corona of penis	http://purl.obolibrary.org/obo/UBERON_0016408		pheno_slim
CHEBI:33664	biolink:ChemicalSubstance	monocyclic hydrocarbon			hp.json	monocyclic hydrocarbons|monocyclic hydrocarbons|monocyclic hydrocarbon	http://purl.obolibrary.org/obo/CHEBI_33664		3_STAR
PATO:0002135	biolink:NamedThing	delayed closure	A duration quality of a process inhering in a bearer by virtue of the bearer's delay to complete the closure of the opening of an anatomical entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0002135		
UBERON:0016409	biolink:AnatomicalEntity	base of glans penis		FMA:19649	hp.json	glans penile base	http://purl.obolibrary.org/obo/UBERON_0016409		pheno_slim
HP:0004502	biolink:PhenotypicFeature	Bilateral choanal atresia	Bilateral absence (atresia) of the posterior nasal aperture (choana).	UMLS:C4025317	hp.json	Bilateral blockage of the rear opening of the nasal cavity|Bilateral obstruction of the rear opening of the nasal cavity	http://purl.obolibrary.org/obo/HP_0004502		
UBERON:0004437	biolink:AnatomicalEntity	proximal epiphysis of middle phalanx of manual digit 3	A proximal epiphysis that is part of a middle phalanx of manual digit 3 [Automatically generated definition].	FMA:37514	hp.json	base of middle phalanx of middle finger|base of middle phalanx of third finger|proximal epiphysis of middle phalanx of manual digit III|base of middle phalanx of third digit of hand|basal epiphysis of middle phalanx of middle finger|proximal epiphysis of middle phalanx of middle finger	http://purl.obolibrary.org/obo/UBERON_0004437		
UBERON:0004438	biolink:AnatomicalEntity	proximal epiphysis of middle phalanx of manual digit 4	A proximal epiphysis that is part of a middle phalanx of manual digit 4 [Automatically generated definition].	FMA:37526	hp.json	base of middle phalanx of ring finger|proximal epiphysis of middle phalanx of manual digit IV|basal epiphysis of middle phalanx of fourth finger|basal epiphysis of middle phalanx of ring finger|base of middle phalanx of fourth digit of hand|proximal epiphysis of middle phalanx of ring finger|base of middle phalanx of fourth finger	http://purl.obolibrary.org/obo/UBERON_0004438		
UBERON:0004435	biolink:AnatomicalEntity	proximal epiphysis of distal phalanx of manual digit 5	A proximal epiphysis that is part of a distal phalanx of manual digit 5 [Automatically generated definition].	FMA:37541	hp.json	proximal epiphysis of distal phalanx of manual digit V|base of distal phalanx of fifth digit of hand|basal epiphysis of distal phalanx of little finger|base of distal phalanx of fifth finger|proximal epiphysis of distal phalanx of little finger|base of distal phalanx of little finger|basal epiphysis of distal phalanx of fifth finger	http://purl.obolibrary.org/obo/UBERON_0004435		
UBERON:0004436	biolink:AnatomicalEntity	proximal epiphysis of middle phalanx of manual digit 2	A proximal epiphysis that is part of a middle phalanx of manual digit 2 [Automatically generated definition].	FMA:37502	hp.json	base of middle phalanx of index finger|base of middle phalanx of second finger|proximal epiphysis of middle phalanx of index finger|basal epiphysis of middle phalanx of index finger|base of middle phalanx of second digit of hand|proximal epiphysis of middle phalanx of manual digit II	http://purl.obolibrary.org/obo/UBERON_0004436		
UBERON:0004433	biolink:AnatomicalEntity	proximal epiphysis of distal phalanx of manual digit 3	A proximal epiphysis that is part of a distal phalanx of manual digit 3 [Automatically generated definition].	FMA:37517	hp.json	base of distal phalanx of middle finger|base of distal phalanx of third digit of hand|proximal epiphysis of distal phalanx of manual digit III|base of distal phalanx of third finger|proximal epiphysis of distal phalanx of middle finger	http://purl.obolibrary.org/obo/UBERON_0004433		
UBERON:0004434	biolink:AnatomicalEntity	proximal epiphysis of distal phalanx of manual digit 4	A proximal epiphysis that is part of a distal phalanx of manual digit 4 [Automatically generated definition].	FMA:37529	hp.json	basal epiphysis of distal phalanx of fourth finger|base of distal phalanx of fourth digit of hand|basal epiphysis of distal phalanx of ring finger|proximal epiphysis of distal phalanx of ring finger|base of distal phalanx of fourth finger|proximal epiphysis of distal phalanx of manual digit IV|base of distal phalanx of ring finger	http://purl.obolibrary.org/obo/UBERON_0004434		
UBERON:0004431	biolink:AnatomicalEntity	proximal epiphysis of fifth metatarsal bone	A proximal epiphysis that is part of a metatarsal bone of digit 5 [Automatically generated definition].	FMA:42967	hp.json	proximal epiphysis of metatarsal 5|base of fifth metatarsal bone|proximal end of fifth metatarsal bone	http://purl.obolibrary.org/obo/UBERON_0004431		
UBERON:0004432	biolink:AnatomicalEntity	proximal epiphysis of distal phalanx of manual digit 2	A proximal epiphysis that is part of a distal phalanx of manual digit 2 [Automatically generated definition].	FMA:37505	hp.json	base of distal phalanx of second digit of hand|base of distal phalanx of index finger|proximal epiphysis of distal phalanx of manual digit II|proximal epiphysis of distal phalanx of index finger|basal epiphysis of distal phalanx of index finger|base of distal phalanx of second finger	http://purl.obolibrary.org/obo/UBERON_0004432		
HP:0100369	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the 3rd toe		UMLS:C4022122	hp.json	Absent/small outermost 3rd toe bone|Absent/underdeveloped outermost 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100369		
HP:0100367	biolink:PhenotypicFeature	Short phalanx of the 4th toe	Developmental hypoplasia of one or more phalanx of fourth toe.	UMLS:C4021013	hp.json	Short 4th toe bone|Short phalanx of the fourth toe|Hypoplastic/small phalanges of the 4th toe	http://purl.obolibrary.org/obo/HP_0100367		
HP:0100368	biolink:PhenotypicFeature	Short phalanx of the 5th toe	Developmental hypoplasia of one or more phalanx of little toe.	UMLS:C4021012	hp.json	Short pinky toe bone|Short phalanx of the fifth toe|Hypoplastic/small phalanges of the 5th toe|Short pinkie toe bone|Short little toe bone	http://purl.obolibrary.org/obo/HP_0100368		
HP:0100366	biolink:PhenotypicFeature	Short phalanx of the 3rd toe	Developmental hypoplasia of the phalanx of third toe.	UMLS:C4021014	hp.json	Short phalanx of the third toe|Short 3rd toe bone|Hypoplastic/small phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100366		
HP:0100363	biolink:PhenotypicFeature	Aplasia of the phalanges of the 4th toe		UMLS:C4022124	hp.json	Absent bones of the 4th toe	http://purl.obolibrary.org/obo/HP_0100363		
HP:0100364	biolink:PhenotypicFeature	Aplasia of the phalanges of the 5th toe		UMLS:C4022123	hp.json	Absent little toe bones|Absent pinky toe bones|Absent pinkie toe bones	http://purl.obolibrary.org/obo/HP_0100364		
GO:0007599	biolink:BiologicalProcess	hemostasis	The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.	Wikipedia:Hemostasis	hp.json		http://purl.obolibrary.org/obo/GO_0007599		
HP:0100362	biolink:PhenotypicFeature	Aplasia of the phalanges of the 3rd toe		UMLS:C4022125	hp.json	Absent digital bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100362		
GO:0007598	biolink:BiologicalProcess	blood coagulation, extrinsic pathway	A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X.		hp.json		http://purl.obolibrary.org/obo/GO_0007598		
GO:0007597	biolink:BiologicalProcess	blood coagulation, intrinsic pathway	A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.		hp.json		http://purl.obolibrary.org/obo/GO_0007597		
HP:0100360	biolink:PhenotypicFeature	Upper-limb joint contracture	A limitation in the passive range of motion of a joint of the upper limb resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin.	UMLS:C2750635	hp.json	Contractures of the joints of the upper limbs	http://purl.obolibrary.org/obo/HP_0100360		
GO:0007596	biolink:BiologicalProcess	blood coagulation	The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.	Wikipedia:Coagulation	hp.json	blood clotting	http://purl.obolibrary.org/obo/GO_0007596		
GO:0007595	biolink:NamedThing	lactation			hp.json		http://purl.obolibrary.org/obo/GO_0007595		
HP:0100378	biolink:PhenotypicFeature	Absent distal phalanx of the 3rd toe	Developmental aplasia of the distal phalanx of third toe.	UMLS:C4021011	hp.json	Absent outermost bone of the 3rd toe|Aplasia of the distal phalanx of the 3rd toe|Absent distal phalanx of the third toe	http://purl.obolibrary.org/obo/HP_0100378		
HP:0100379	biolink:PhenotypicFeature	Aplasia of the distal phalanx of the 4th toe		UMLS:C4022113	hp.json	Absent distal phalanx of the 4th toe|Absent outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100379		
HP:0100376	biolink:PhenotypicFeature	Aplasia/hypoplasia of the proximal phalanx of the 4th toe	Absence (agenesis) or underdevelopment of the proximal phalanx of the 4th toe.	UMLS:C4022115	hp.json	Absent/small innermost 4th toe bone|Absent/underdeveloped innermost 4th toe bone	http://purl.obolibrary.org/obo/HP_0100376		
HP:0100377	biolink:PhenotypicFeature	Aplasia/hypoplasia of the proximal phalanx of the 5th toe	Absence (agenesis) or underdevelopment of the proximal phalanx of the 5th toe.	UMLS:C4022114	hp.json	Absent/small innermost pinkie toe bone|Absent/small innermost little toe bone|Absent/underdeveloped innermost 5th toe bone|Absent/small innermost pinky toe bone	http://purl.obolibrary.org/obo/HP_0100377		
HP:0100374	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanx of the 5th toe		UMLS:C4022117	hp.json	Absent/underdeveloped middle bone of little toe|Absent/underdeveloped middle bone of pinkie toe|Absent/small middle 5th toe bone|Absent/underdeveloped middle bone of pinky toe	http://purl.obolibrary.org/obo/HP_0100374		
HP:0100375	biolink:PhenotypicFeature	Aplasia/hypoplasia of the proximal phalanx of the 3rd toe	Absence (agenesis) or underdevelopment of the proximal phalanx of the 3rd toe.	UMLS:C4022116	hp.json	Absent/underdeveloped innermost bone of 3rd toe|Absent/small innermost bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0100375		
HP:0100372	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanx of the 3rd toe		UMLS:C4022119	hp.json	Absent/small middle 3rd toe bone|Absent/underdeveloped middle 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100372		
HP:0100373	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle phalanx of the 4th toe		UMLS:C4022118	hp.json	Absent/underdeveloped middle bone of the 4th toe|Absent/small middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100373		
HP:0100370	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the 4th toe		UMLS:C4022121	hp.json	Absent/small outermost bone of 4th toe|Absent/underdeveloped outermost bone of 4th toe	http://purl.obolibrary.org/obo/HP_0100370		
HP:0100371	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the distal phalanx of the 5th toe		UMLS:C4022120	hp.json	Absent/small outermost pinkie toe bone|Absent/small outermost little toe bone|Absent/underdeveloped outermost pinky toe bone|Absent/small outermost pinky toe bone	http://purl.obolibrary.org/obo/HP_0100371		
PR:000018263	biolink:Protein	amino acid chain	An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds.		hp.json	polypeptide|peptide	http://purl.obolibrary.org/obo/PR_000018263		
PR:000018264	biolink:Protein	proteolytic cleavage product	A protein that is produced as the result of proteolytic processing of a longer protein.		hp.json	ClvPrd|polypeptide|peptide	http://purl.obolibrary.org/obo/PR_000018264		
HP:0100389	biolink:PhenotypicFeature	Short distal phalanx of the 3rd toe	Developmental hypoplasia of the distal phalanx of third toe.	UMLS:C4021008	hp.json	Short distal phalanx of the third toe|Hypoplastic/small distal phalanx of the 3rd toe|Short outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100389		
HP:0100387	biolink:PhenotypicFeature	Aplasia of the middle phalanges of the toes		UMLS:C4022107	hp.json	Absent middle toe bones	http://purl.obolibrary.org/obo/HP_0100387		
HP:0100388	biolink:PhenotypicFeature	Aplasia of the proximal phalanges of the toes		UMLS:C4022106	hp.json	Absent innermost toe bones	http://purl.obolibrary.org/obo/HP_0100388		
HP:0100385	biolink:PhenotypicFeature	Aplasia of the proximal phalanx of the 4th toe		UMLS:C4022109	hp.json	Absent innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100385		
HP:0100386	biolink:PhenotypicFeature	Aplasia of the proximal phalanx of the 5th toe		UMLS:C4022108	hp.json	Absent innermost bone of the pinkie toe|Absent innermost bone of the pinky toe|Absent innermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100386		
GO:0044566	biolink:BiologicalProcess	chondrocyte activation	A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage.		hp.json		http://purl.obolibrary.org/obo/GO_0044566		
HP:0100383	biolink:PhenotypicFeature	Aplasia of the middle phalanx of the 5th toe		UMLS:C4022110	hp.json	Absent middle bone of little toe|Absent middle bone of pinkie toe|Absent middle bone of pinky toe	http://purl.obolibrary.org/obo/HP_0100383		
HP:0100384	biolink:PhenotypicFeature	Absent proximal phalanx of the 3rd toe	Absence of proximal phalanx of third toe, owing to a congenital defect of development.	UMLS:C4021009	hp.json	Absent innermost bone of the 3rd toe|Aplasia of the proximal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100384		
HP:0100381	biolink:PhenotypicFeature	Absent middle phalanx of the 3rd toe	Developmental aplasia of the middle phalanx of third toe.	UMLS:C4021010	hp.json	Aplasia of the middle phalanx of the 3rd toe|Absent middle bone of the 3rd toe|Absent middle phalanx of the third toe	http://purl.obolibrary.org/obo/HP_0100381		
HP:0100382	biolink:PhenotypicFeature	Aplasia of the middle phalanx of the 4th toe		UMLS:C4022111	hp.json	Absent middle bone of 4th toe	http://purl.obolibrary.org/obo/HP_0100382		
GO:0044565	biolink:BiologicalProcess	dendritic cell proliferation	The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.		hp.json		http://purl.obolibrary.org/obo/GO_0044565		
HP:0100380	biolink:PhenotypicFeature	Aplasia of the distal phalanx of the 5th toe		UMLS:C4022112	hp.json	Absent outermost bone of the pinkie toe|Absent outermost bone of the pinky toe|Absent outermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100380		
NCBITaxon:2605435	biolink:OrganismalEntity	Evosea		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_2605435		
NCBITaxon:8287	biolink:OrganismalEntity	Sarcopterygii		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_8287		
HP:0100398	biolink:PhenotypicFeature	Duplication of the distal phalanx of the 3rd toe	Partial or complete duplication of distal phalanx of third toe.	UMLS:C4020999	hp.json	Duplication of the distal phalanx of the third toe|Duplication of the outermost bone of the 3rd toe|Partial/complete duplication of the distal phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100398		
HP:0100399	biolink:PhenotypicFeature	Duplication of the distal phalanx of the 4th toe	Partial or complete duplication of the distal phalanx of fourth toe.	UMLS:C4020998	hp.json	Duplication of the distal phalanx of the fourth toe|Duplication of the outermost bone of the 4th toe|Partial/complete duplication of the distal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100399		
HP:0100396	biolink:PhenotypicFeature	Short proximal phalanx of the 4th toe	Developmental hypoplasia of the proximal phalanx of fourth toe.	UMLS:C4021001	hp.json	Short fourth toe proximal phalanx|Short proximal phalanx of the fourth toe|Hypoplastic/small proximal phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100396		
HP:0100397	biolink:PhenotypicFeature	Short proximal phalanx of the 5th toe	Developmental hypoplasia of the proximal phalanx of fifth toe.	UMLS:C4021000	hp.json	Short innermost bone of pinky toe|Short innermost bone of pinkie toe|Short proximal phalanx of the fifth toe|Hypoplastic/small proximal phalanx of the 5th toe|Short innermost bone of little toe	http://purl.obolibrary.org/obo/HP_0100397		
GO:0007589	biolink:BiologicalProcess	body fluid secretion	The controlled release of a fluid by a cell or tissue in an animal.		hp.json		http://purl.obolibrary.org/obo/GO_0007589		
HP:0100394	biolink:PhenotypicFeature	Short middle phalanx of the 5th toe	Developmental hypoplasia of the middle phalanx of the 5th toe.	UMLS:C4021003	hp.json	Short middle bone of little toe|Hypoplastic/small middle phalanx of the 5th toe|Short middle bone of pinkie toe|Short middle phalanx of the fifth toe|Short middle bone of pinky toe	http://purl.obolibrary.org/obo/HP_0100394		
GO:0007588	biolink:BiologicalProcess	excretion	The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.	Wikipedia:Excretion	hp.json		http://purl.obolibrary.org/obo/GO_0007588		gocheck_do_not_annotate|goslim_pir
HP:0100395	biolink:PhenotypicFeature	Short proximal phalanx of the 3rd toe	Abnormal reduction in length of proximal phalanx of third toe.	UMLS:C4021002	hp.json	Hypoplastic/small proximal phalanx of the 3rd toe|Short proximal phalanx of the third toe	http://purl.obolibrary.org/obo/HP_0100395		
HP:0100392	biolink:PhenotypicFeature	Short middle phalanx of the 3rd toe	Developmental hypoplasia of the middle phalanx of third toe.	UMLS:C4021005	hp.json	Short middle phalanx of the third toe|Hypoplastic/small middle phalanx of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100392		
GO:0007586	biolink:BiologicalProcess	digestion	The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.	Wikipedia:Digestion	hp.json		http://purl.obolibrary.org/obo/GO_0007586		goslim_pir|goslim_chembl
HP:0100393	biolink:PhenotypicFeature	Short middle phalanx of the 4th toe	Developmental hypoplasia of the middle phalanx of fourth toe.	UMLS:C4021004	hp.json	Short middle phalanx of the fourth toe|Short middle bone of 4th toe|Hypoplastic/small middle phalanx of the 4th toe	http://purl.obolibrary.org/obo/HP_0100393		
GO:0007585	biolink:BiologicalProcess	respiratory gaseous exchange by respiratory system	The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.		hp.json	breathing|respiration	http://purl.obolibrary.org/obo/GO_0007585		goslim_chembl
HP:0100390	biolink:PhenotypicFeature	Short distal phalanx of the 4th toe	Developmental hypoplasia of the distal phalanx of fourth toe.	UMLS:C4021007	hp.json	Hypoplastic/small distal phalanx of the 4th toe|Short outermost bone of the 4th toe|Short distal phalanx of the fourth toe	http://purl.obolibrary.org/obo/HP_0100390		
HP:0100391	biolink:PhenotypicFeature	Short distal phalanx of the 5th toe	Developmental hypoplasia of the distal phalanx of little toe.	UMLS:C4021006	hp.json	Short distal phalanx of the fifth toe|Short outermost bone of the little toe|Hypoplastic/small distal phalanx of the 5th toe|Short outermost bone of the pinkie toe|Short outermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100391		
GO:0019538	biolink:BiologicalProcess	protein metabolic process	The chemical reactions and pathways involving a protein. Includes protein modification.	Wikipedia:Protein_metabolism	hp.json	multicellular organismal protein metabolic process|cellular protein metabolic process|protein metabolic process and modification|protein metabolism and modification|cellular protein metabolism|protein metabolism	http://purl.obolibrary.org/obo/GO_0019538		goslim_mouse|goslim_agr|goslim_pir|goslim_plant|goslim_flybase_ribbon
UBERON:0004503	biolink:AnatomicalEntity	skeletal muscle tissue of digastric	A portion of skeletal muscle tissue that is part of a digastric [Automatically generated definition].	FMA:261872	hp.json		http://purl.obolibrary.org/obo/UBERON_0004503		
UBERON:0004504	biolink:AnatomicalEntity	skeletal muscle tissue of mylohyoid	A portion of skeletal muscle tissue that is part of a mylohyoid [Automatically generated definition].	FMA:261878	hp.json		http://purl.obolibrary.org/obo/UBERON_0004504		
UBERON:0004502	biolink:AnatomicalEntity	skeletal muscle tissue of biceps brachii	A portion of skeletal muscle tissue that is part of a biceps brachii [Automatically generated definition].	FMA:261974	hp.json	skeletal muscle tissue of biceps brachii muscle	http://purl.obolibrary.org/obo/UBERON_0004502		
UBERON:0004500	biolink:AnatomicalEntity	skeletal muscle tissue of deltoid	A portion of skeletal muscle tissue that is part of a deltoid [Automatically generated definition].	FMA:261732	hp.json	skeletal muscle tissue of deltoid muscle	http://purl.obolibrary.org/obo/UBERON_0004500		
GO:0032504	biolink:BiologicalProcess	multicellular organism reproduction	The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.		hp.json		http://purl.obolibrary.org/obo/GO_0032504		goslim_drosophila
GO:0032502	biolink:BiologicalProcess	developmental process	A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.		hp.json	single-organism developmental process|development	http://purl.obolibrary.org/obo/GO_0032502		goslim_agr|goslim_pir|goslim_flybase_ribbon|goslim_aspergillus
GO:0032501	biolink:BiologicalProcess	multicellular organismal process	Any biological process, occurring at the level of a multicellular organism, pertinent to its function.		hp.json	single-multicellular organism process|organismal physiological process	http://purl.obolibrary.org/obo/GO_0032501		gocheck_do_not_annotate|goslim_pir
GO:0007567	biolink:BiologicalProcess	parturition	The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.		hp.json	egg laying|giving birth	http://purl.obolibrary.org/obo/GO_0007567		
GO:0007566	biolink:BiologicalProcess	embryo implantation	Attachment of the blastocyst to the uterine lining.		hp.json	blastocyst implantation	http://purl.obolibrary.org/obo/GO_0007566		
GO:0007565	biolink:BiologicalProcess	female pregnancy	The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.	Wikipedia:Gestation	hp.json	gestation|carrying of young	http://purl.obolibrary.org/obo/GO_0007565		goslim_chembl
GO:0007548	biolink:BiologicalProcess	sex differentiation	The establishment of the sex of an organism by physical differentiation.	Wikipedia:Sexual_differentiation	hp.json		http://purl.obolibrary.org/obo/GO_0007548		
OBO:uberon/core#anteriorly_connected_to	biolink:NamedThing	anteriorly connected to	x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y.		hp.json		http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to		
OBO:uberon/core#in_innermost_side_of	biolink:NamedThing	in_innermost_side_of			hp.json		http://purl.obolibrary.org/obo/uberon/core#in_innermost_side_of		
HP:0002094	biolink:PhenotypicFeature	Dyspnea	Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.	MSH:D004417|SNOMEDCT_US:267036007|UMLS:C0013404|SNOMEDCT_US:230145002	hp.json	Difficulty breathing|Shortness of breath|Trouble breathing|Dyspnoea|Breathing difficulty|Panting|Abnormal breathing|Difficult to breathe	http://purl.obolibrary.org/obo/HP_0002094		
NBO:0000586	biolink:NamedThing	opisthotonus	"A form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward." [JAX:]		hp.json		http://purl.obolibrary.org/obo/NBO_0000586		
HP:0002092	biolink:PhenotypicFeature	Pulmonary arterial hypertension	Pulmonary hypertension is defined mean pulmonary artery pressure of 25mmHg or more and pulmonary capillary wedge pressure of 15mmHg or less when measured by right heart catheterisation at rest and in a supine position.	SNOMEDCT_US:11399002|SNOMEDCT_US:70995007|UMLS:C2973725|SNOMEDCT_US:697898008|MSH:D006976|UMLS:C0020542|UMLS:C3203102|MSH:D065627	hp.json	Increased blood pressure in blood vessels of lungs|Pulmonary artery hypertension|Primary pulmonary hypertension	http://purl.obolibrary.org/obo/HP_0002092		
HP:0002093	biolink:PhenotypicFeature	Respiratory insufficiency		UMLS:C4020855|SNOMEDCT_US:409623005|UMLS:C0035229|MSH:D012131	hp.json	Respiratory function loss|Respiratory impairment	http://purl.obolibrary.org/obo/HP_0002093		
HP:0002098	biolink:PhenotypicFeature	Respiratory distress	Respiratory distress is objectively observable as the physical or emotional consequences from the experience of dyspnea. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.	UMLS:C0476273|MSH:D004417|SNOMEDCT_US:267036007|SNOMEDCT_US:271825005|UMLS:C0013404|SNOMEDCT_US:230145002	hp.json	Labored breathing|Respiratory difficulties|Breathing difficulties	http://purl.obolibrary.org/obo/HP_0002098		
HP:0002099	biolink:PhenotypicFeature	Asthma	Asthma is characterized by increased responsiveness of the tracheobronchial tree to multiple stimuli, leading to narrowing of the air passages with resultant dyspnea, cough, and wheezing.	SNOMEDCT_US:991000119106|UMLS:C3714497|MSH:D001249|UMLS:C0004096|SNOMEDCT_US:195967001	hp.json	Bronchial asthma|Reactive airway disease|Asthma	http://purl.obolibrary.org/obo/HP_0002099		
HP:0002097	biolink:PhenotypicFeature	Emphysema		MSH:D011656|SNOMEDCT_US:87433001|UMLS:C0034067	hp.json	Pulmonary emphysema	http://purl.obolibrary.org/obo/HP_0002097		
NBO:0000589	biolink:NamedThing	tremor	"An involuntary rhythmical, oscillatory movement of a body part." [NBO:GVG]		hp.json	quivering|shivering|trembling	http://purl.obolibrary.org/obo/NBO_0000589		
NBO:0000588	biolink:NamedThing	spasm	"A sudden, involuntary contraction of a muscle or group of muscles." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000588		
NBO:0000587	biolink:NamedThing	tetanic spasm	"A sudden, involuntary contraction of a muscle or group of muscles associated with strychnine poisoning and tetanus." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000587		
NBO:0000591	biolink:NamedThing	motor coordination phenotype	"Observable characteristic of behavior related to the coordination of combinations of body movements created with the kinematic (such as spatial direction) and kinetic (force) parameters that result in intended actions." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000591		
HP:0100303	biolink:PhenotypicFeature	Muscle fiber cytoplasmatic inclusion bodies	The presence of inclusion bodies within the cytoplasm of muscle cells. Inclusion bodies are aggregates (deposits) or stainable material, usually misfolded proteins.	UMLS:C4022157	hp.json	Muscle fibre cytoplasmatic inclusion bodies|Muscle fibre cytoplasmic bodies|Muscle fiber cytoplasmic bodies	http://purl.obolibrary.org/obo/HP_0100303		
HP:0100304	biolink:PhenotypicFeature	Muscle fiber intranuclear inclusion bodies	The presence of inclusion bodies within the nucleus of muscle cells. Inclusion bodies are aggregates (deposits) or stainable material, usually misfolded proteins.	UMLS:C4022156	hp.json	Muscle fibre intranuclear inclusion bodies	http://purl.obolibrary.org/obo/HP_0100304		
HP:0100301	biolink:PhenotypicFeature	Muscle fiber tubular inclusions	Unusual regions of densely packed membranous tubules known as tubular aggregates which present as membranous inclusions, derived from membranes of sarcoplasmic reticulum and mitochondria, containing miscellaneous proteins with a variety of enzymatic activities.	UMLS:C4021024	hp.json	Muscle fiber tubular aggregates|Muscle fibre tubular inclusions|Muscle fibre tubular aggregates	http://purl.obolibrary.org/obo/HP_0100301		
HP:0100302	biolink:PhenotypicFeature	Muscle fiber tubuloreticular inclusions		UMLS:C4021023	hp.json	Muscle fiber tubuloreticular aggregates|Muscle fibre tubuloreticular inclusions|Muscle fibre tubuloreticular aggregates	http://purl.obolibrary.org/obo/HP_0100302		
HP:0100300	biolink:PhenotypicFeature	Desmin bodies		UMLS:C4022158	hp.json		http://purl.obolibrary.org/obo/HP_0100300		
HP:0002080	biolink:PhenotypicFeature	Intention tremor	A type of kinetic tremor that occurs during target directed movement is called intention tremor. That is, an oscillatory cerebellar ataxia that tends to be absent when the limbs are inactive and during the first part of voluntary movement but worsening as the movement continues and greater precision is required (e.g., in touching a target such as the patient's nose or a physician's finger).	SNOMEDCT_US:30721006|MSH:D014202|UMLS:C0234376|UMLS:C4020856	hp.json	Cerebellar tremor|Terminal tremor	http://purl.obolibrary.org/obo/HP_0002080		
HP:0002078	biolink:PhenotypicFeature	Truncal ataxia	Truncal ataxia is a sign of ataxia characterized by instability of the trunk. It usually occurs during sitting.	UMLS:C0427190|MSH:D001259|SNOMEDCT_US:250067008	hp.json	Instability or lack of coordination of central trunk muscles|Trunk ataxia	http://purl.obolibrary.org/obo/HP_0002078		
HP:0002079	biolink:PhenotypicFeature	Hypoplasia of the corpus callosum	Underdevelopment of the corpus callosum.	SNOMEDCT_US:204043002|UMLS:C0344482	hp.json	Corpus callosum hypoplasia|Hypoplasia of corpus callosum|Hypoplastic corpus callosum|Underdevelopment of part of brain called corpus callosum	http://purl.obolibrary.org/obo/HP_0002079		
HP:0002072	biolink:PhenotypicFeature	Chorea	Chorea (Greek for 'dance') refers to widespread arrhythmic involuntary movements of a forcible, jerky and restless fashion. It is a random-appearing sequence of one or more discrete involuntary movements or movement fragments. Movements appear random because of variability in timing, duration or location. Each movement may have a distinct start and end. However, movements may be strung together and thus may appear to flow randomly from one muscle group to another. Chorea can involve the trunk, neck, face, tongue, and extremities.	UMLS:C4020858|SNOMEDCT_US:271700006|UMLS:C0008489|MSH:D002819	hp.json	Choreiform movements|Choreatic disease|Choreic movements	http://purl.obolibrary.org/obo/HP_0002072		
NBO:0000564	biolink:NamedThing	social behavior phenotype	"Observable characteristic of behavior that occurs predominantly or only, in individuals that are part of a group." [NBO:GVG]		hp.json	pathological social behaviour	http://purl.obolibrary.org/obo/NBO_0000564		
HP:0002073	biolink:PhenotypicFeature	Progressive cerebellar ataxia		SNOMEDCT_US:230233000|UMLS:C0393525	hp.json	Progressive ataxia|Cerebellar ataxia, progressive	http://purl.obolibrary.org/obo/HP_0002073		
HP:0100309	biolink:PhenotypicFeature	Subdural hemorrhage	Hemorrhage occurring between the dura mater and the arachnoid mater.	UMLS:C0018946|SNOMEDCT_US:35486000|MSH:D006408|SNOMEDCT_US:95453001	hp.json	Subdural haemorrhage|Subdural haematoma|Subdural hematoma	http://purl.obolibrary.org/obo/HP_0100309		
HP:0002070	biolink:PhenotypicFeature	Limb ataxia	A kind of ataxia that affects movements of the extremities.	UMLS:C0750937|MSH:D001259	hp.json	Appendicular ataxia	http://purl.obolibrary.org/obo/HP_0002070		
HP:0002071	biolink:PhenotypicFeature	Abnormality of extrapyramidal motor function	A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless).	MSH:D001480|UMLS:C0234133|SNOMEDCT_US:43378000|UMLS:C0015371|SNOMEDCT_US:76349003	hp.json	Extrapyramidal syndrome|Extrapyramidal tract signs|Extrapyramidal signs|Extrapyramidal dysfunction|Extrapyramidal symptoms	http://purl.obolibrary.org/obo/HP_0002071		
HP:0002076	biolink:PhenotypicFeature	Migraine	Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.	UMLS:C0149931|MSH:D008881|UMLS:C0744641|SNOMEDCT_US:37796009	hp.json	Migraine|Migraine headaches|Migraine headache|Intermittent migraine headaches	http://purl.obolibrary.org/obo/HP_0002076		
HP:0100307	biolink:PhenotypicFeature	Cerebellar hemisphere hypoplasia		UMLS:C4022154	hp.json		http://purl.obolibrary.org/obo/HP_0100307		
HP:0100308	biolink:PhenotypicFeature	Cerebral cortical hemiatrophy	Atrophy of one side of the brain, characterized by findings including thinning of the cerebral cortex, reduced volume of the cerebral white matter with abnormal myelination, and enlargement of the ispilateral fourth ventricle.	UMLS:C4022153	hp.json		http://purl.obolibrary.org/obo/HP_0100308		
HP:0002077	biolink:PhenotypicFeature	Migraine with aura	A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.	SNOMEDCT_US:4473006|MSH:D020325|UMLS:C0154723	hp.json		http://purl.obolibrary.org/obo/HP_0002077		
HP:0002074	biolink:PhenotypicFeature	Increased neuronal autofluorescent lipopigment	Lipofuscin, a generic term applied to autofluorescent lipopigment, is a mixture of protein and lipid that accumulates in most aging cells, particularly those involved in high lipid turnover (e.g., the adrenal medulla) or phagocytosis of other cell types (e g., the retinal pigment epithelium or RPE; macrophage). This term pertains if there is an increase in the neuronal accumulation of lipofuscin (also known as autofluorescent lipoprotein) more than expected for the age of the patient.	UMLS:C4020857|UMLS:C4025728	hp.json	Neuronal lipopigments	http://purl.obolibrary.org/obo/HP_0002074		
HP:0100305	biolink:PhenotypicFeature	Ring fibers	Ring fibers are formed by a bundle of peripheral myofibrils which are circumferentially oriented such that they encircle the internal portion of the sarcoplasm which is normal in structure and orientation.	SNOMEDCT_US:47913008|UMLS:C0333770	hp.json	Ring fibres	http://purl.obolibrary.org/obo/HP_0100305		
HP:0002075	biolink:PhenotypicFeature	Dysdiadochokinesis	A type of ataxia characterized by the impairment of the ability to perform rapidly alternating movements, such as pronating and supinating his or her hand on the dorsum of the other hand as rapidly as possible.	SNOMEDCT_US:23133003|UMLS:C0234979	hp.json	Dysdiadochokinesia|Difficulty performing quick and alternating movements	http://purl.obolibrary.org/obo/HP_0002075		
HP:0100306	biolink:PhenotypicFeature	Muscle fiber hyaline bodies		UMLS:C4022155	hp.json	Muscle fibre hyaline bodies	http://purl.obolibrary.org/obo/HP_0100306		
HP:0100314	biolink:PhenotypicFeature	Cerebral inclusion bodies	Nuclear or cytoplasmic aggregates of stainable substances within cells of the brain.	UMLS:C4022149	hp.json		http://purl.obolibrary.org/obo/HP_0100314		
HP:0100315	biolink:PhenotypicFeature	Lewy bodies		MSH:D016631|UMLS:C0752347|SNOMEDCT_US:312991009|MSH:D020961|SNOMEDCT_US:43127003|SNOMEDCT_US:80098002|UMLS:C0085200	hp.json	Lewy body disease	http://purl.obolibrary.org/obo/HP_0100315		
HP:0100312	biolink:PhenotypicFeature	Cerebral germinoma	The presence of a germ cell tumor of the cerebrum.	UMLS:C4022151|NCIT:C3708	hp.json		http://purl.obolibrary.org/obo/HP_0100312		
HP:0100313	biolink:PhenotypicFeature	Cerebral granulomatosis	Cerebral inflammation involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells.	UMLS:C4022150	hp.json		http://purl.obolibrary.org/obo/HP_0100313		
HP:0100310	biolink:PhenotypicFeature	Epidural hemorrhage	Hemorrhage occurring between the dura mater and the skull.	SNOMEDCT_US:82999001|SNOMEDCT_US:428268007|UMLS:C0238154|MSH:D006407	hp.json	Extradural haematoma|Extradural hematoma|Epidural haemorrhage|Epidural hematoma|Epidural haematoma	http://purl.obolibrary.org/obo/HP_0100310		
NBO:0000568	biolink:NamedThing	kinesthetic behavior phenotype	"Observable characteristic of behavior related to the movement of the body's muscles, tendons, and joints." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000568		
HP:0002090	biolink:PhenotypicFeature	Pneumonia	Inflammation of any part of the lung parenchyma.	MSH:D011014|SNOMEDCT_US:233604007|UMLS:C0032285	hp.json	Pneumonia	http://purl.obolibrary.org/obo/HP_0002090		
NBO:0000567	biolink:NamedThing	stereotypic behavior	"A pathological behavior associated with repetitive or ritualistic movement, posture, or utterance." [wikipedia:Stereotypy]		hp.json	stereotypic behaviour|stereotypy	http://purl.obolibrary.org/obo/NBO_0000567		
HP:0100311	biolink:PhenotypicFeature	Cerebral ventricular adhesions	Bands of scar-like tisssue that hve formed within a cerebral ventricle.	UMLS:C4022152	hp.json		http://purl.obolibrary.org/obo/HP_0100311		
HP:0002091	biolink:PhenotypicFeature	Restrictive ventilatory defect	A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Spirometrically, a restrictive defect is defined as FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) less than 80 per cent. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus.	UMLS:C3277226|SNOMEDCT_US:36485005|UMLS:C0085581	hp.json	Spirometric restriction|Restrictive lung disease|Restrictive respiratory disease|Restrictive respiratory insufficiency|Stiff lung or chest wall causing decreased lung volume|Restrictive deficit on pulmonary function tests|Restrictive deficit on pulmonary function testing|Restrictive respiratory syndrome	http://purl.obolibrary.org/obo/HP_0002091		
HP:0002089	biolink:PhenotypicFeature	Pulmonary hypoplasia		UMLS:C0265783|SNOMEDCT_US:80825009	hp.json	Underdeveloped lung|Small lung|Lung hypoplasia|Poorly developed lungs|Hypoplastic lung|Hypoplastic lungs	http://purl.obolibrary.org/obo/HP_0002089		
HP:0002083	biolink:PhenotypicFeature	Migraine without aura	Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia.	MSH:D020326|SNOMEDCT_US:56097005|UMLS:C0338480	hp.json		http://purl.obolibrary.org/obo/HP_0002083		
HP:0002084	biolink:PhenotypicFeature	Encephalocele	A neural tube defect characterized by sac-like protrusions of the brain and the membranes that cover it through openings in the skull.	SNOMEDCT_US:48777005|UMLS:C0014065|SNOMEDCT_US:55999004|SNOMEDCT_US:253101008|MSH:D004677	hp.json	Bifid skull|Cranium bifidum	http://purl.obolibrary.org/obo/HP_0002084		
HP:0002087	biolink:PhenotypicFeature	Abnormality of the upper respiratory tract	An abnormality of the upper respiratory tract.	UMLS:C4025727	hp.json	Abnormality of the upper respiratory tract|Upper respiratory tract issues	http://purl.obolibrary.org/obo/HP_0002087		
HP:0100318	biolink:PhenotypicFeature	Lafora bodies	An intraneuronal inclusion body composed of acid mucopolysaccharides.	SNOMEDCT_US:87554006|UMLS:C0333749	hp.json		http://purl.obolibrary.org/obo/HP_0100318		
HP:0002088	biolink:PhenotypicFeature	Abnormal lung morphology	Any structural anomaly of the lung.	SNOMEDCT_US:19829001|MSH:D008171|UMLS:C4021760|UMLS:C0024115	hp.json	Abnormally shaped lung|Abnormality of lung structure|Abnormality of the lungs|Unusal lung shape|Lung disease	http://purl.obolibrary.org/obo/HP_0002088		
HP:0100319	biolink:PhenotypicFeature	Cerebral hyaline bodies	Cerebral eosinophilic, discrete, intracytoplasmatic inclusions of unknown significance.	UMLS:C4021021	hp.json	Cerebral colloid bodies	http://purl.obolibrary.org/obo/HP_0100319		
HP:0002085	biolink:PhenotypicFeature	Occipital encephalocele	A type of encephalocele (that is, a a protrusion of part of the cranial contents including brain tissue through a congenital opening in the cranium, typically covered with skin or mucous membrane) in the occipital region of the skull. Occipital encephalocele presents as a midline swelling over the occipital bone. It is usually covered with normal full-thickness scalp.	SNOMEDCT_US:42376006|UMLS:C0014067|MSH:D004677	hp.json	Brain tissue sticks out through back of skull|Occipital meningoencephalocele|Posterior encephalocele	http://purl.obolibrary.org/obo/HP_0002085		
HP:0100316	biolink:PhenotypicFeature	Hirano bodies	Intracellular aggregates of actin and actin-associated proteins within nerve cells.	UMLS:C0521178|SNOMEDCT_US:57458003	hp.json		http://purl.obolibrary.org/obo/HP_0100316		
HP:0100317	biolink:PhenotypicFeature	Argyrophilic inclusion bodies	Presence of abundant argyrophilic grains and coiled bodies on microscopic examination of brain tissue.	UMLS:C4021022	hp.json	Agyrophilic inclusion bodies|Pick inclusion bodies	http://purl.obolibrary.org/obo/HP_0100317		
HP:0002086	biolink:PhenotypicFeature	Abnormality of the respiratory system	An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles.	UMLS:C4018871	hp.json	Respiratory abnormality	http://purl.obolibrary.org/obo/HP_0002086		
HP:0100326	biolink:PhenotypicFeature	Immunologic hypersensitivity	Immunological states where the immune system produces harmful responses upon reexposure to sensitising antigens.	UMLS:C0237653	hp.json		http://purl.obolibrary.org/obo/HP_0100326		
HP:0100323	biolink:PhenotypicFeature	Juvenile aseptic necrosis	Juvenile aseptic necrosis comprises a group of orthopedic diseases characterized by interruption of the blood supply of a bone, followed by localized bony necrosis most often of the epiphyses of bones of children or teenagers.	UMLS:C4020710|UMLS:C4022146	hp.json	Aseptic epiphyseal necrosis	http://purl.obolibrary.org/obo/HP_0100323		
HP:0100324	biolink:PhenotypicFeature	Scleroderma	A chronic autoimmune phenomenon characterized by fibrosis (or hardening) and vascular alterations of the skin.	UMLS:C1274865|SNOMEDCT_US:89155008|UMLS:C0011644|SNOMEDCT_US:403524003|MSH:D012594	hp.json	Pseudoscleroderma|Progressive systemic scleroderma	http://purl.obolibrary.org/obo/HP_0100324		
HP:0100321	biolink:PhenotypicFeature	Abnormal dentate nucleus morphology	An abnormality of the dentate nucleus.	UMLS:C4022148	hp.json	Abnormality of the dentate nucleus	http://purl.obolibrary.org/obo/HP_0100321		
HP:0100322	biolink:PhenotypicFeature	Aplasia of the pyramidal tract		UMLS:C4022147	hp.json	Absent pyramidal tract	http://purl.obolibrary.org/obo/HP_0100322		
HP:0100320	biolink:PhenotypicFeature	Rosenthal fibers	Thick, elongated, worm-like or corkscrew eosinophilic bundle that are found on H&E staining of the brain in the presence of long standing gliosis, occasional tumors, and some metabolic disorders.	SNOMEDCT_US:84605001|UMLS:C0333731	hp.json	Rosenthal fibres	http://purl.obolibrary.org/obo/HP_0100320		
NCBITaxon:32525	biolink:OrganismalEntity	Theria <mammals>		GC_ID:1	hp.json	Theria	http://purl.obolibrary.org/obo/NCBITaxon_32525		
NCBITaxon:32524	biolink:OrganismalEntity	Amniota		GC_ID:1	hp.json	amniotes	http://purl.obolibrary.org/obo/NCBITaxon_32524		
NCBITaxon:32523	biolink:OrganismalEntity	Tetrapoda		GC_ID:1	hp.json	tetrapods	http://purl.obolibrary.org/obo/NCBITaxon_32523		
HP:0100329	biolink:PhenotypicFeature	Tarsometatarsal synostosis		UMLS:C4022144	hp.json	Fused bones of the midfoot	http://purl.obolibrary.org/obo/HP_0100329		
GO:0032594	biolink:BiologicalProcess	protein transport within lipid bilayer	The directed movement of a protein from one location to another within a lipid bilayer.		hp.json	protein translocation within membrane|receptor translocation within membrane|receptor transport within lipid bilayer	http://purl.obolibrary.org/obo/GO_0032594		
HP:0100327	biolink:PhenotypicFeature	Cow milk allergy	Hypersensitivity in form of an adverse immune reaction against cow milk protein.	SNOMEDCT_US:15911003|UMLS:C0266815	hp.json	IgE-mediated cow milk allergy|Immunoglobulin E-mediated cow milk allergy|Cow milk allergy|Milk allergy	http://purl.obolibrary.org/obo/HP_0100327		
HP:0100328	biolink:PhenotypicFeature	Carpometacarpal synostosis	Fusion involving carpal and metacarpal bones.	UMLS:C4022145	hp.json	Fused wrist bones and long bones of hand	http://purl.obolibrary.org/obo/HP_0100328		
HP:0100336	biolink:PhenotypicFeature	Bilateral cleft lip	A non-midline cleft of the upper lip on the left and right sides.	SNOMEDCT_US:304068004|UMLS:C0392005	hp.json	Bilateral cheiloschisis|Right and left cleft lip|Both sided cleft lip	http://purl.obolibrary.org/obo/HP_0100336		hposlim_core
HP:0100337	biolink:PhenotypicFeature	Bilateral cleft palate	Nonmidline cleft palate on the left and right sides.	UMLS:C3553084	hp.json	Bilateral palatoschisis|Right and left cleft palate	http://purl.obolibrary.org/obo/HP_0100337		hposlim_core
HP:0100334	biolink:PhenotypicFeature	Unilateral cleft palate		UMLS:C4022143	hp.json	One sided cleft palate|Unilateral palatoschisis	http://purl.obolibrary.org/obo/HP_0100334		
HP:0100335	biolink:PhenotypicFeature	Non-midline cleft lip	Clefting of the upper lip affecting the lateral portions of the upper lip rather than the midline/median region.	UMLS:C4021020	hp.json	Paramedian cleft of the upper lip|Non-midline cleft of the upper lip	http://purl.obolibrary.org/obo/HP_0100335		
HP:0100333	biolink:PhenotypicFeature	Unilateral cleft lip	A non-midline cleft of the upper lip on one side only.	UMLS:C0392006|SNOMEDCT_US:304067009	hp.json	Unilateral cleft upper lip|Unilateral cheiloschisis|One sided cleft upper lip	http://purl.obolibrary.org/obo/HP_0100333		
GO:0032589	biolink:CellularComponent	neuron projection membrane	The portion of the plasma membrane surrounding a neuron projection.		hp.json		http://purl.obolibrary.org/obo/GO_0032589		
HP:0100338	biolink:PhenotypicFeature	Non-midline cleft palate		UMLS:C4022142	hp.json	Paramedian cleft palate	http://purl.obolibrary.org/obo/HP_0100338		
HP:0100339	biolink:PhenotypicFeature	Abnormality of the os naviculare pedis		UMLS:C4022141	hp.json		http://purl.obolibrary.org/obo/HP_0100339		
HP:0100347	biolink:PhenotypicFeature	Tibial deviation of the 5th toe		UMLS:C4022133	hp.json		http://purl.obolibrary.org/obo/HP_0100347		
HP:0100348	biolink:PhenotypicFeature	Contracture of the proximal interphalangeal joint of the 2nd toe	The proximal interphalangeal joint of the 2nd toe cannot be straightened actively or passively.	UMLS:C4021019	hp.json	Camptodactyly of the second toe|Camptodactyly of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100348		
HP:0100345	biolink:PhenotypicFeature	Tibial deviation of the 2nd toe		UMLS:C4022135	hp.json		http://purl.obolibrary.org/obo/HP_0100345		
HP:0100346	biolink:PhenotypicFeature	Fibular deviation of the 5th toe		UMLS:C4022134	hp.json		http://purl.obolibrary.org/obo/HP_0100346		
HP:0100343	biolink:PhenotypicFeature	Tibial deviation of the 3rd toe		UMLS:C4022137	hp.json		http://purl.obolibrary.org/obo/HP_0100343		
HP:0100344	biolink:PhenotypicFeature	Fibular deviation of the 2nd toe		UMLS:C4022136	hp.json		http://purl.obolibrary.org/obo/HP_0100344		
HP:0100341	biolink:PhenotypicFeature	Tibial deviation of the 4th toe		UMLS:C4022139	hp.json		http://purl.obolibrary.org/obo/HP_0100341		
NBO:0000598	biolink:NamedThing	dystonia	"A locomotory disorder in which sustained muscle contractions cause twisting and repetitive movements or abnormal postures." [wikipedia:Dystonia]		hp.json		http://purl.obolibrary.org/obo/NBO_0000598		
HP:0100342	biolink:PhenotypicFeature	Fibular deviation of the 3rd toe		UMLS:C4022138	hp.json		http://purl.obolibrary.org/obo/HP_0100342		
HP:0100340	biolink:PhenotypicFeature	Fibular deviation of the 4th toe		UMLS:C4022140	hp.json		http://purl.obolibrary.org/obo/HP_0100340		
CHEBI:176843	biolink:ChemicalSubstance	vitamin B12	Any member of a group of cobalamin vitamers that exhibit biological activity against vitamin B12 deficiency. Vitamin B12 deficiency is associated with low red blood cell count and anemia. The vitamers are found in foods such as cereals, meat, fish, and poultry. The vitamers include adenosylcobalamin, hydroxocobalamin, cyanocobalamin, aquacobalamin, nitritocobalamin and methylcobabalamin (also includes their ionized, salt and phosphate derivatives).		hp.json	vitamins B12|vitamin B12 vitamers|vitamin B12 vitamer|vitamin B12|vitamin B-12	http://purl.obolibrary.org/obo/CHEBI_176843		3_STAR
CHEBI:176842	biolink:ChemicalSubstance	vitamin B9	Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.		hp.json	vitamins B9|vitamin B9 vitamers|vitamin B-9|vitamin B9 vitamer|vitamin B9|folate vitamers|folate vitamer	http://purl.obolibrary.org/obo/CHEBI_176842		3_STAR
HP:0100349	biolink:PhenotypicFeature	Contracture of the proximal interphalangeal joint of the 3rd toe	The proximal interphalangeal joint of the 3rd toe cannot be straightened actively or passively.	UMLS:C4021018	hp.json	Camptodactyly of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100349		
HP:0100358	biolink:PhenotypicFeature	Contracture of the metatarsophalangeal joint of the 4th toe	The joint between the fourth metatarsal and the proximal phalanx of the fourth toe cannot be straightened actively or passively.	UMLS:C4022127	hp.json		http://purl.obolibrary.org/obo/HP_0100358		
HP:0100359	biolink:PhenotypicFeature	Contracture of the metatarsophalangeal joint of the 5th toe	The joint between the fifth metatarsal and the proximal phalanx of the fifth toe cannot be straightened actively or passively.	UMLS:C4022126	hp.json		http://purl.obolibrary.org/obo/HP_0100359		
HP:0100356	biolink:PhenotypicFeature	Contracture of the metatarsophalangeal joint of the 2nd toe	The joint between the second metatarsal and the proximal phalanx of the 2nd toe cannot be straightened actively or passively.	UMLS:C4022129	hp.json		http://purl.obolibrary.org/obo/HP_0100356		
HP:0100357	biolink:PhenotypicFeature	Contracture of the metatarsophalangeal joint of the 3rd toe	The joint between the third metatarsal and the proximal phalanx of the third toe cannot be straightened actively or passively.	UMLS:C4022128	hp.json		http://purl.obolibrary.org/obo/HP_0100357		
HP:0100354	biolink:PhenotypicFeature	Contracture of the distal interphalangeal joint of the 4th toe	The distal interphalangeal joint of the 4th toe cannot be straightened actively or passively.	UMLS:C4022131	hp.json		http://purl.obolibrary.org/obo/HP_0100354		
HP:0100355	biolink:PhenotypicFeature	Contractures of the distal interphalangeal joint of the 5th toe	The distal interphalangeal joint of the 5th toe cannot be straightened actively or passively.	UMLS:C4022130	hp.json	Contracture of the outermost hinge joint of the 5th toe	http://purl.obolibrary.org/obo/HP_0100355		
HP:0100352	biolink:PhenotypicFeature	Contracture of the distal interphalangeal joint of the 2nd toe	The distal interphalangeal joint of the 2nd toe cannot be straightened actively or passively.	UMLS:C4021015	hp.json	Contracture of the distal interphalangeal joint of the second toe	http://purl.obolibrary.org/obo/HP_0100352		
HP:0100353	biolink:PhenotypicFeature	Contracture of the distal interphalangeal joint of the 3rd toe	The distal interphalangeal joint of the 3rd toe cannot be straightened actively or passively.	UMLS:C4022132	hp.json		http://purl.obolibrary.org/obo/HP_0100353		
HP:0100350	biolink:PhenotypicFeature	Contracture of the proximal interphalangeal joint of the 4th toe	The proximal interphalangeal joint of the 4th toe cannot be straightened actively or passively.	UMLS:C4021017	hp.json	Contracture of the innermost hinge joint of the 4th toe|Camptodactyly of the 4th toe|Camptodactyly of the fourth toe	http://purl.obolibrary.org/obo/HP_0100350		
HP:0100351	biolink:PhenotypicFeature	Contractures of the proximal interphalangeal joint of the 5th toe	The proximal interphalangeal joint of the fifth toe cannot be straightened actively or passively.	UMLS:C4021016	hp.json	Camptodactyly of the 5th toe|Camptodactyly of the fifth toe	http://purl.obolibrary.org/obo/HP_0100351		
PR:000008894	biolink:Protein	iduronate 2-sulfatase	A protein that is a translation product of the human IDS gene or a 1:1 ortholog thereof.		hp.json	idursulfase|SIDS|IDS|alpha-L-iduronate sulfate sulfatase	http://purl.obolibrary.org/obo/PR_000008894		
CHEBI:33515	biolink:ChemicalSubstance	transition element cation			hp.json	transition metal cation|transition element cations	http://purl.obolibrary.org/obo/CHEBI_33515		3_STAR
HP:0002014	biolink:PhenotypicFeature	Diarrhea	Abnormally increased frequency (usually defined as three or more) loose or watery bowel movements a day.	SNOMEDCT_US:62315008|MSH:D003967|UMLS:C0011991|SNOMEDCT_US:267060006	hp.json	Watery stool|Diarrhoea|Diarrhea	http://purl.obolibrary.org/obo/HP_0002014		
HP:0002015	biolink:PhenotypicFeature	Dysphagia	Difficulty in swallowing.	SNOMEDCT_US:40739000|SNOMEDCT_US:288939007|MEDDRA:10013950|UMLS:C0011168|MSH:D003680	hp.json	Swallowing difficulty|Deglutition disorder|Swallowing difficulties|Difficulty swallowing|Poor swallowing	http://purl.obolibrary.org/obo/HP_0002015		hposlim_core
HP:0004676	biolink:PhenotypicFeature	Prominent supraorbital arches in adult		UMLS:C1834993	hp.json		http://purl.obolibrary.org/obo/HP_0004676		
HP:0002012	biolink:PhenotypicFeature	Abnormality of the abdominal organs	An abnormality of the viscera of the abdomen.	UMLS:C4021764	hp.json	Abnormality of the abdominal organs|Gastrointestinal tract defects	http://purl.obolibrary.org/obo/HP_0002012		
HP:0002013	biolink:PhenotypicFeature	Vomiting	Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.	SNOMEDCT_US:422400008|MEDDRA:10047700|UMLS:C0042963|SNOMEDCT_US:300359004|SNOMEDCT_US:249497008|MSH:D014839	hp.json	Throwing up|Emesis|Vomiting	http://purl.obolibrary.org/obo/HP_0002013		hposlim_core
HP:0002018	biolink:PhenotypicFeature	Nausea	A sensation of unease in the stomach together with an urge to vomit.	MEDDRA:10028813|UMLS:C0027497|SNOMEDCT_US:422587007|MSH:D009325	hp.json	Nausea	http://purl.obolibrary.org/obo/HP_0002018		hposlim_core
HP:0002019	biolink:PhenotypicFeature	Constipation	Infrequent or difficult evacuation of feces.	SNOMEDCT_US:225595004|SNOMEDCT_US:14760008|MSH:D003248|UMLS:C0009806|UMLS:C0237326	hp.json	Costiveness|Constipation|Dyschezia	http://purl.obolibrary.org/obo/HP_0002019		
HP:0004679	biolink:PhenotypicFeature	Large tarsal bones		UMLS:C1859116	hp.json	Large ankle bones	http://purl.obolibrary.org/obo/HP_0004679		
HP:0002017	biolink:PhenotypicFeature	Nausea and vomiting	Nausea is a commonly encountered symptom that has been defined as an unpleasant painless subjective feeling that one will imminently vomit. Vomiting has been defined as the forceful expulsion of the contents of the stomach, duodenum, or jejunum through the oral cavity. While nausea and vomiting are often thought to exist on a temporal continuum, this is not always the case. There are situations when severe nausea may be present without emesis and less frequently, when emesis may be present without preceding nausea.	UMLS:C0027498|SNOMEDCT_US:16932000	hp.json	Nausea and vomiting	http://purl.obolibrary.org/obo/HP_0002017		
HP:0002010	biolink:PhenotypicFeature	Narrow maxilla		UMLS:C1851835	hp.json	Decreased width of upper jaw bones|Transverse hypoplasia of maxilla|Narrow upper jaw bones|Transverse maxillary deficiency|Decreased width of maxilla|Transverse maxillary insufficiency|Decreased transverse dimension of maxilla|Decreased breadth of upper jaw bones	http://purl.obolibrary.org/obo/HP_0002010		
HP:0004673	biolink:PhenotypicFeature	Decreased facial expression	A reduced degree of voluntary and involuntary facial movements involved in responded to others or expressing emotions.	UMLS:C1862474	hp.json	Decreased facial expression	http://purl.obolibrary.org/obo/HP_0004673		
HP:0002011	biolink:PhenotypicFeature	Morphological central nervous system abnormality	A structural abnormality of the central nervous system.	UMLS:C4021765|SNOMEDCT_US:23853001|UMLS:C0007682|MSH:D002493	hp.json	Morphological abnormality of the CNS|Central nervous system disease|Morphological abnormality of the central nervous system|Abnormality of the central nervous system	http://purl.obolibrary.org/obo/HP_0002011		
NCBITaxon:32561	biolink:OrganismalEntity	Sauria		GC_ID:1	hp.json	Diapsida|diapsids	http://purl.obolibrary.org/obo/NCBITaxon_32561		
HP:0004688	biolink:PhenotypicFeature	Irregular tarsal bones		UMLS:C1855240	hp.json	Abnormal shape of ankle bones	http://purl.obolibrary.org/obo/HP_0004688		
HP:0002025	biolink:PhenotypicFeature	Anal stenosis	Abnormal narrowing of the anal opening.	SNOMEDCT_US:69914001|MEDDRA:10002176|UMLS:C0262374|SNOMEDCT_US:250037002	hp.json	Narrowing of anal opening	http://purl.obolibrary.org/obo/HP_0002025		hposlim_core
HP:0002023	biolink:PhenotypicFeature	Anal atresia	Congenital absence of the anus, i.e., the opening at the bottom end of the intestinal tract.	Fyler:4443|SNOMEDCT_US:204731006|MSH:D001006|MEDDRA:10002120|UMLS:C0003466|SNOMEDCT_US:204712000|Fyler:4402	hp.json	Imperforate anus|Absent anus	http://purl.obolibrary.org/obo/HP_0002023		hposlim_core
HP:0004686	biolink:PhenotypicFeature	Short third metatarsal	Underdevelopment of the Third metatarsal bone leading to a short (hypoplastic) third metatarsal bone.	UMLS:C4021650	hp.json	Hypoplasia of the 3rd metatarsal bone|Short 3rd long bone of foot	http://purl.obolibrary.org/obo/HP_0004686		
HP:0002024	biolink:PhenotypicFeature	Malabsorption	Impaired ability to absorb one or more nutrients from the intestine.	UMLS:C3714745	hp.json	Intestinal malabsorption|Malabsorption	http://purl.obolibrary.org/obo/HP_0002024		
CHEBI:33521	biolink:ChemicalSubstance	metal atom	An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity.	KEGG:C00050|PMID:21784043|Wikipedia:Metal	hp.json	metals|elemental metals|metal element|metal elements|elemental metal	http://purl.obolibrary.org/obo/CHEBI_33521		3_STAR
HP:0002027	biolink:PhenotypicFeature	Abdominal pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.	UMLS:C0000737|MEDDRA:10000081|SNOMEDCT_US:21522001|MSH:D015746	hp.json	Upset stomach|Gastrointestinal pain|Abdominal discomfort|Pain in stomach|Stomach pain|Abdominal pain|Gastro pain	http://purl.obolibrary.org/obo/HP_0002027		hposlim_core
HP:0002028	biolink:PhenotypicFeature	Chronic diarrhea	The presence of chronic diarrhea, which is usually taken to mean diarrhea that has persisted for over 4 weeks.	UMLS:C0401151|SNOMEDCT_US:236071009	hp.json	Diarrhea, recurrent|Chronic diarrhoea|Recurrent diarrhoea|Recurrent diarrhea|Chronic diarrhea	http://purl.obolibrary.org/obo/HP_0002028		
HP:0004689	biolink:PhenotypicFeature	Short fourth metatarsal	Short fourth metatarsal bone.	UMLS:C1848514	hp.json	Short fourth metatarsus|Short fourth metatarsals|Short 4th long bone of foot|Bilateral fourth metatarsal shortening	http://purl.obolibrary.org/obo/HP_0004689		
HP:0004684	biolink:PhenotypicFeature	Talipes valgus	Outward turning of the heel, resulting in clubfoot with the person walking on the inner part of the foot.	UMLS:C0152236|SNOMEDCT_US:79807003	hp.json		http://purl.obolibrary.org/obo/HP_0004684		
HP:0002021	biolink:PhenotypicFeature	Pyloric stenosis	Pyloric stenosis, also known as infantile hypertrophic pyloric stenosis, is an uncommon condition in infants characterized by abnormal thickening of the pylorus muscles in the stomach leading to gastric outlet obstruction. Clinically infants are well at birth. Then, at 3 to 6 weeks of age, the infants present with projectile vomiting, potentially leading to dehydration and weight loss.	MSH:D011707|SNOMEDCT_US:367403001|MEDDRA:10037621|Fyler:4444|UMLS:C0034194	hp.json	Infantile hypertrophic pyloric stenosis|Pylorus stenosis	http://purl.obolibrary.org/obo/HP_0002021		hposlim_core
HP:0004681	biolink:PhenotypicFeature	Deep longitudinal plantar crease	Narrow, paramedian longitudinal depressions in the plantar skin of the forefoot.	UMLS:C1859223|UMLS:C4280508	hp.json	Foot crease|Longitudinal groove on soles	http://purl.obolibrary.org/obo/HP_0004681		hposlim_core
HP:0002020	biolink:PhenotypicFeature	Gastroesophageal reflux	A condition in which the stomach contents leak backwards from the stomach into the esophagus through the lower esophageal sphincter.	SNOMEDCT_US:698065002|MSH:D005764|UMLS:C0018834|MSH:D006356|SNOMEDCT_US:16331000|SNOMEDCT_US:235595009|UMLS:C0017168	hp.json	Gastro-oesophageal reflux|Acid reflux disease|Heartburn|Gastroesophageal reflux disease|Gastro-esophageal reflux|GERD|Acid reflux	http://purl.obolibrary.org/obo/HP_0002020		hposlim_core
GO:0140241	biolink:BiologicalProcess	translation at synapse	Translation that occurs at the synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0140241		goslim_synapse
GO:0140243	biolink:BiologicalProcess	regulation of translation at synapse	Any process that regulates translation occurring at the synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0140243		goslim_synapse
GO:0140242	biolink:BiologicalProcess	translation at postsynapse	Translation that occurs at the postsynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0140242		goslim_synapse
GO:0140245	biolink:BiologicalProcess	regulation of translation at postsynapse	Any process that regulates translation occurring at the postsynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0140245		goslim_synapse
GO:0140244	biolink:BiologicalProcess	regulation of translation at presynapse	Any process that regulates translation occurring at the presynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0140244		goslim_synapse
UBERON:0016570	biolink:AnatomicalEntity	lamina of gray matter of spinal cord		http://neurolex.org/wiki/Category:Rexed_spinal_cord_parcellation_scheme_region|Wikipedia:Rexed_laminae|FMA:68861	hp.json	rexed lamina	http://purl.obolibrary.org/obo/UBERON_0016570		
GO:0140236	biolink:BiologicalProcess	translation at presynapse	Translation that occurs at the presynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0140236		goslim_synapse
HGNC:5147	biolink:Gene	HPD (human)	A protein coding gene HPD in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5147		
CHEBI:33504	biolink:ChemicalSubstance	alkali metal cation			hp.json	alkali metal cations	http://purl.obolibrary.org/obo/CHEBI_33504		3_STAR
HP:0002009	biolink:PhenotypicFeature	Potter facies	A facial appearance characteristic of a fetus or neonate due to oligohydramnios experienced in the womb, comprising ocular hypertelorism, low-set ears, receding chin, and flattening of the nose.	UMLS:C0266619|SNOMEDCT_US:24814002	hp.json		http://purl.obolibrary.org/obo/HP_0002009		
GO:0140237	biolink:BiologicalProcess	translation at presynapse, modulating chemical synaptic transmission	Translation that occurs at the presynapse, and that modulates chemical synaptic transmission.		hp.json		http://purl.obolibrary.org/obo/GO_0140237		goslim_synapse
HP:0002003	biolink:PhenotypicFeature	Large forehead		UMLS:C4280584|UMLS:C4280583|UMLS:C1839783	hp.json	Increased size of frontal region of face|Large forehead|Hyperplasia of forehead|Hypertrophy of forehead|Increased size of forehead	http://purl.obolibrary.org/obo/HP_0002003		
HP:0004664	biolink:PhenotypicFeature	Facial midline hemangioma	Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the midline region of the face.	UMLS:C1862496	hp.json		http://purl.obolibrary.org/obo/HP_0004664		
HP:0002002	biolink:PhenotypicFeature	Deep philtrum	Accentuated, prominent philtral ridges giving rise to an exaggerated groove in the midline between the nasal base and upper vermillion border.	UMLS:C4020861|UMLS:C1839797	hp.json	Philtrum, deep|Pronounced philtrum|Prominent philtrum|Depressed philtrum|Increased depth of philtrum	http://purl.obolibrary.org/obo/HP_0002002		hposlim_core
HP:0002007	biolink:PhenotypicFeature	Frontal bossing	Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline.	UMLS:C0221354|SNOMEDCT_US:90145001	hp.json	Frontal protruberance|Skull bossing	http://purl.obolibrary.org/obo/HP_0002007		hposlim_core
UBERON:0004590	biolink:AnatomicalEntity	sphincter muscle	A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.	UMLS:C1409894|FMA:75004|NCIT:C28381	hp.json	sphincter|circular muscle	http://purl.obolibrary.org/obo/UBERON_0004590		
HP:0002006	biolink:PhenotypicFeature	Facial cleft	A congenital malformation with a cleft (gap or opening) in the face.	SNOMEDCT_US:92821006|UMLS:C0685787	hp.json	Facial clefts|Cleft of the face|Facial cleft|Tessier facial cleft	http://purl.obolibrary.org/obo/HP_0002006		hposlim_core
HP:0002000	biolink:PhenotypicFeature	Short columella	Reduced distance from the anterior border of the naris to the subnasale.	UMLS:C1857479|UMLS:C4280585	hp.json	Decreased length of columella|Columella, short|Hypoplasia of columella	http://purl.obolibrary.org/obo/HP_0002000		hposlim_core
HP:0004661	biolink:PhenotypicFeature	Frontalis muscle weakness	Reduced strength of the frontalis muscle (which is located on the forehead).	UMLS:C1859438	hp.json	Weakness of forehead muscle|Weak frontalis muscle	http://purl.obolibrary.org/obo/HP_0004661		
HP:0004660	biolink:PhenotypicFeature	Hypoplasia of facial musculature	Underdevelopment of one or more muscles innervated by the facial nerve (the seventh cranial nerve).	UMLS:C4280509|UMLS:C1834042|UMLS:C4280511|UMLS:C4280510	hp.json	Small facial muscles|Hypotrophic facial musculature|Underdevelopment of facial muscles|Atrophy of facial musculature|Deficiency of facial musculature|Decreased size of facial muscles	http://purl.obolibrary.org/obo/HP_0004660		
NBO:0000539	biolink:NamedThing	eating behavior phenotype	"Observable characteristic of feeding behavior that relates to eating." [NBO:GVG]		hp.json	eating disorder	http://purl.obolibrary.org/obo/NBO_0000539		
HP:0002058	biolink:PhenotypicFeature	Myopathic facies	A facial appearance characteristic of myopathic conditions. The face appears expressionless with sunken cheeks, bilateral ptosis, and inability to elevate the corners of the mouth, due to muscle weakness.	UMLS:C0332615|SNOMEDCT_US:26432009	hp.json	Myopathic face|Myopathic facial appearance	http://purl.obolibrary.org/obo/HP_0002058		
HP:0002059	biolink:PhenotypicFeature	Cerebral atrophy	Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum.	UMLS:C4020860|SNOMEDCT_US:278849000|UMLS:C0235946|SNOMEDCT_US:52522001|UMLS:C0154671|SNOMEDCT_US:418143002	hp.json	Supratentorial atrophy|Degeneration of cerebrum	http://purl.obolibrary.org/obo/HP_0002059		
HP:0002056	biolink:PhenotypicFeature	Abnormality of the glabella	An abnormality of the glabella.	UMLS:C4021763	hp.json	Malformation of the area between the eyebrows|Deformity of the area between the eyebrows|Abnormality of the area between the eyebrows|Glabellar abnormality	http://purl.obolibrary.org/obo/HP_0002056		
HP:0002057	biolink:PhenotypicFeature	Prominent glabella	Forward protrusion of the glabella.	UMLS:C1860247	hp.json	Hyperplasia of glabella|Convex glabella|Protruding area between the eyebrows|Prominent area between the eyebrows	http://purl.obolibrary.org/obo/HP_0002057		hposlim_core
HP:0002050	biolink:PhenotypicFeature	Macroorchidism, postpubertal		UMLS:C1839782	hp.json		http://purl.obolibrary.org/obo/HP_0002050		
NBO:0000542	biolink:NamedThing	polydipsia	"A pathological drinking behavior characterised by large intake of fluids by mouth, usually due to excessive thirst that is relatively prolonged." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000542		
NBO:0000541	biolink:NamedThing	dipsosis	"A pathological drinking behavior characterised by an excessive desire to drink." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000541		
NBO:0000540	biolink:NamedThing	drinking behavior phenotype	"Observable characteristic of feeding behavior that relates to drinking." [NBO:GVG]		hp.json	pathological drinking behaviour|drinking disorder	http://purl.obolibrary.org/obo/NBO_0000540		
HP:0002054	biolink:PhenotypicFeature	Heavy supraorbital ridges		UMLS:C1845107	hp.json	Heavy brow of the face|Heavy supraorbital ridge	http://purl.obolibrary.org/obo/HP_0002054		
PATO:0002062	biolink:NamedThing	physical quality of a process			hp.json		http://purl.obolibrary.org/obo/PATO_0002062		attribute_slim
HP:0002055	biolink:PhenotypicFeature	Curved linear dimple below the lower lip		UMLS:C1844572	hp.json		http://purl.obolibrary.org/obo/HP_0002055		
NBO:0000546	biolink:NamedThing	polyphagia	"A pathological eating behavior characterised by an abnormally large intake of food by mouth, usually due to excessive hunger that is relatively prolonged." [NBO:GVG]		hp.json	hyperphagia	http://purl.obolibrary.org/obo/NBO_0000546		
NBO:0000544	biolink:NamedThing	aphagia	"A pathological feeding behavior characterised by failure to eat." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000544		
NBO:0000543	biolink:NamedThing	hyperdipsia	"A pathological drinking behavior characterised by an excessive relative temporal desire to drink." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000543		
HP:0002069	biolink:PhenotypicFeature	Bilateral tonic-clonic seizure	A bilateral tonic-clonic seizure is a seizure defined by a tonic (bilateral increased tone, lasting seconds to minutes) and then a clonic (bilateral sustained rhythmic jerking) phase.	MSH:D012640|UMLS:C0494475|SNOMEDCT_US:54200006	hp.json	Generalised convulsion|Bilateral convulsive seizures|Tonic-clonic convulsion|Generalised tonic-clonic seizure (without specification of onset)|Generalized convulsion|Seizures, tonic-clonic|Grand mal|Generalized tonic-clonic seizure (without specification of onset)|Tonic-clonic convulsions|Grand mal seizures	http://purl.obolibrary.org/obo/HP_0002069		
PATO:0002076	biolink:NamedThing	movement behavioral quality	A behavioral quality inhering in a bearer by virtue of the bearer's movement.		hp.json	movement behavioural quality	http://purl.obolibrary.org/obo/PATO_0002076		attribute_slim
HP:0002067	biolink:PhenotypicFeature	Bradykinesia	Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement).	UMLS:C0233565|SNOMEDCT_US:399317006|MSH:D018476	hp.json	Slow movements|Slowness of movements	http://purl.obolibrary.org/obo/HP_0002067		
HP:0002068	biolink:PhenotypicFeature	Neuromuscular dysphagia		UMLS:C4025729	hp.json		http://purl.obolibrary.org/obo/HP_0002068		
PATO:0002078	biolink:NamedThing	hollow	A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within.		hp.json		http://purl.obolibrary.org/obo/PATO_0002078		value_slim
HP:0002061	biolink:PhenotypicFeature	Lower limb spasticity	Spasticity (velocity-dependent increase in tonic stretch reflexes with increased muscle tone and hyperexcitable tendon reflexes) in the muscles of the lower limbs, hips, and pelvis	SNOMEDCT_US:394679006|UMLS:C1271100	hp.json		http://purl.obolibrary.org/obo/HP_0002061		
HP:0002062	biolink:PhenotypicFeature	Morphological abnormality of the pyramidal tract	Any structural abnormality of the pyramidal tract, whose chief element, the corticospinal tract, is the only direct connection between the brain and the spinal cord. In addition to the corticospinal tract, the pyramidal system includes the corticobulbar, corticomesencephalic, and corticopontine tracts.	UMLS:C4020859|UMLS:C4021761	hp.json	Pyramidal tract disease|Abnormality of the pyramidal tracts	http://purl.obolibrary.org/obo/HP_0002062		
HP:0002060	biolink:PhenotypicFeature	Abnormal cerebral morphology	Any structural abnormality of the telencephalon, which is also known as the cerebrum.	UMLS:C4021762	hp.json	Abnormality of the cerebrum|Abnormality of the telencephalon|Cerebral lesion	http://purl.obolibrary.org/obo/HP_0002060		
HP:0002066	biolink:PhenotypicFeature	Gait ataxia	A type of ataxia characterized by the impairment of the ability to coordinate the movements required for normal walking. Gait ataxia is characteirzed by a wide-based staggering gait with a tendency to fall.	MSH:D020234|UMLS:C0751837|SNOMEDCT_US:25136009	hp.json	Inability to coordinate movements when walking|Ataxic gait|Ataxia of gait	http://purl.obolibrary.org/obo/HP_0002066		
HP:0002063	biolink:PhenotypicFeature	Rigidity	Continuous involuntary sustained muscle contraction. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from muscle spasticity.	MSH:D009127|UMLS:C0026837|SNOMEDCT_US:16046003	hp.json	Rigidity|Muscle rigidity	http://purl.obolibrary.org/obo/HP_0002063		
HP:0002064	biolink:PhenotypicFeature	Spastic gait	Spasticity is manifested by increased stretch reflex which is intensified with movement velocity. This results in excessive and inappropriate muscle activation which can contribute to muscle hypertonia. Spastic gait is characterized by manifestations such as muscle hypertonia, stiff knee, and circumduction of the leg.	MSH:D020233|SNOMEDCT_US:9447003|UMLS:C0231687	hp.json	Spastic walk	http://purl.obolibrary.org/obo/HP_0002064		
NBO:0000515	biolink:NamedThing	depressive disorder			hp.json	depressive disorder not otherwise specified|DD-NOS	http://purl.obolibrary.org/obo/NBO_0000515		
HP:0002036	biolink:PhenotypicFeature	Hiatus hernia	The presence of a hernia in which the upper part of the stomach, i.e., mainly the gastric cardia protrudes through the diaphragmatic esophageal hiatus.	SNOMEDCT_US:84089009|MEDDRA:10020028|MSH:D006551|UMLS:C3489393	hp.json	Stomach hernia|Hiatal hernia	http://purl.obolibrary.org/obo/HP_0002036		hposlim_core
HP:0004699	biolink:PhenotypicFeature	Osteoporotic metatarsal	Decrease in mass and density of the metatarsal bones.	UMLS:C1836873	hp.json		http://purl.obolibrary.org/obo/HP_0004699		
PATO:0002087	biolink:NamedThing	bullet-shaped	A quality inhering in a bearer by virtue of the bearer's being short and wide and tapered distally.		hp.json		http://purl.obolibrary.org/obo/PATO_0002087		value_slim
HP:0002037	biolink:PhenotypicFeature	Inflammation of the large intestine	Inflammation, or an inflammatory state in the large intestine.	UMLS:C0021390|SNOMEDCT_US:24526004|SNOMEDCT_US:302168000|MSH:D015212|UMLS:C0578878	hp.json	Inflammation of the large intestine|Inflammatory bowel disease	http://purl.obolibrary.org/obo/HP_0002037		
HP:0002034	biolink:PhenotypicFeature	Abnormal rectum morphology	An abnormaltiy of the rectum, the final segment of the large intestine that stores solid waste until it passes through the anus.	UMLS:C0266210|SNOMEDCT_US:86993003	hp.json	Abnormality of the rectum|Anomaly of the rectum	http://purl.obolibrary.org/obo/HP_0002034		
HP:0002035	biolink:PhenotypicFeature	Rectal prolapse	Protrusion of the rectal mucous membrane through the anus.	MSH:D012005|UMLS:C0034888|MEDDRA:10038077|SNOMEDCT_US:57773001	hp.json	Rectal prolapsed|Rectum protrudes through anus	http://purl.obolibrary.org/obo/HP_0002035		hposlim_core
HP:0004696	biolink:PhenotypicFeature	Talipes cavus equinovarus		UMLS:C1832342	hp.json		http://purl.obolibrary.org/obo/HP_0004696		
HP:0002038	biolink:PhenotypicFeature	Protein avoidance		UMLS:C1839531	hp.json		http://purl.obolibrary.org/obo/HP_0002038		
PATO:0002089	biolink:NamedThing	polycystic	A structure quality inhering in a bearer by virtue of the bearer's body containing more than one cyst - formations of sac-like closed membranous structures not associated with neoplasia.		hp.json	multicystic	http://purl.obolibrary.org/obo/PATO_0002089		value_slim
HP:0002039	biolink:PhenotypicFeature	Anorexia	A lack or loss of appetite for food (as a medical condition).	MSH:D000855|SNOMEDCT_US:79890006|UMLS:C0003123	hp.json	Anorexia	http://purl.obolibrary.org/obo/HP_0002039		
HP:0004691	biolink:PhenotypicFeature	2-3 toe syndactyly	Syndactyly with fusion of toes two and three.	UMLS:C0432040|SNOMEDCT_US:205145001	hp.json	partial or complete syndactyly 2nd-3rd toes|2-3 syndactyly of feet|2-3 toes syndactyly|Toe syndactyly, 2-3|Syndactyly of second and third toes|2-3 toe soft tissue syndactyly|Webbed 2nd and 3rd toes	http://purl.obolibrary.org/obo/HP_0004691		
HP:0004690	biolink:PhenotypicFeature	Thickened Achilles tendon	An abnormal thickening of the Achilles tendon.	UMLS:C0919997	hp.json	Thickened Achilles tendon	http://purl.obolibrary.org/obo/HP_0004690		
HP:0002032	biolink:PhenotypicFeature	Esophageal atresia	A developmental defect resulting in complete obliteration of the lumen of the esophagus such that the esophagus ends in a blind pouch rather than connecting to the stomach.	MSH:D004933|SNOMEDCT_US:26179002|UMLS:C0014850|Fyler:4412	hp.json	Birth defect in which part of esophagus did not develop|Birth defect in which part of oesophagus did not develop	http://purl.obolibrary.org/obo/HP_0002032		
PATO:0002083	biolink:NamedThing	altered number of	Having extra or fewer parts.		hp.json		http://purl.obolibrary.org/obo/PATO_0002083		relational_slim|attribute_slim
HP:0004695	biolink:PhenotypicFeature	Calcaneal epiphyseal stippling	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the calcaneus.	UMLS:C1861708	hp.json		http://purl.obolibrary.org/obo/HP_0004695		
HP:0002033	biolink:PhenotypicFeature	Poor suck	An inadequate sucking reflex, resulting in the difficult of newborns to be breast-fed.	UMLS:C1837142	hp.json	Poor suck|Poor sucking|Sucking weakness	http://purl.obolibrary.org/obo/HP_0002033		
HP:0002031	biolink:PhenotypicFeature	Abnormal esophagus morphology	A structural abnormality of the esophagus.	SNOMEDCT_US:69771008|UMLS:C0266126	hp.json	Anomaly of the esophagus|Abnormality of oesophagus structure|Anomaly of the oesophagus|Abnormality of esophagus structure|Abnormal oesophagus morphology	http://purl.obolibrary.org/obo/HP_0002031		
HP:0004692	biolink:PhenotypicFeature	4-5 toe syndactyly	Syndactyly with fusion of toes four and five.	UMLS:C1837836	hp.json	Symmetric syndactyly, toes 4 and 5|Syndactyly of toes 4 and 5|Webbed 4th-5th toes	http://purl.obolibrary.org/obo/HP_0004692		
HP:0002047	biolink:PhenotypicFeature	Malignant hyperthermia	Malignant hyperthermia is characterized by a rapid increase in temperature to 39-42 degrees C in response to inhalational anesthetics such as halothane or to muscle relaxants such as succinylcholine.	SNOMEDCT_US:213026003|MSH:D008305|SNOMEDCT_US:405501007|UMLS:C0024591	hp.json	Malignant hyperthermia with anaesthesia|Malignant hyperthermia with anesthesia	http://purl.obolibrary.org/obo/HP_0002047		
HP:0002048	biolink:PhenotypicFeature	Renal cortical atrophy	Atrophy of the cortex of the kidney.	UMLS:C4025730	hp.json		http://purl.obolibrary.org/obo/HP_0002048		
HP:0002045	biolink:PhenotypicFeature	Hypothermia	Reduced body temperature due to failed thermoregulation.	SNOMEDCT_US:386689009|UMLS:C0020672|MSH:D007035	hp.json	Hypothermia|Abnormally low body temperature	http://purl.obolibrary.org/obo/HP_0002045		
PATO:0002096	biolink:NamedThing	neoplastic, non-malignant	A disposition inhering in a tumour by virtue of the bearer's disposition not to progress, invade surrounding tissues or metastasize.		hp.json	benign	http://purl.obolibrary.org/obo/PATO_0002096		disposition_slim|value_slim|mpath_slim
PATO:0002097	biolink:NamedThing	neoplastic, malignant	A disposition inhering in a tumour by virtue of the bearer's disposition to progress, invade surrounding tissues or metastasize.		hp.json		http://purl.obolibrary.org/obo/PATO_0002097		disposition_slim|value_slim|mpath_slim
HP:0002046	biolink:PhenotypicFeature	Heat intolerance	The inability to maintain a comfortable body temperature in warm or hot weather.	SNOMEDCT_US:69215007|UMLS:C0231274	hp.json	Intolerance to heat and fevers|Heat intolerance	http://purl.obolibrary.org/obo/HP_0002046		hposlim_core
HP:0002049	biolink:PhenotypicFeature	Proximal renal tubular acidosis	A type of renal tubular acidosis characterized by a failure of the proximal tubular cells to reabsorb bicarbonate, leading to urinary bicarbonate wasting and subsequent acidemia.	SNOMEDCT_US:24790002|MSH:D000141|UMLS:C0268435	hp.json	Renal tubular acidosis, proximal|Proximal tubular acidosis|Renal tubular acidosis, type II	http://purl.obolibrary.org/obo/HP_0002049		
HP:0002040	biolink:PhenotypicFeature	Esophageal varix	Extreme dilation of the submucusoal veins in the lower portion of the esophagus.	UMLS:C0014867|MEDDRA:10056091|SNOMEDCT_US:28670008|MSH:D004932	hp.json	Enlarged vein in oesophagus|Esophageal varices|Enlarged vein in esophagus	http://purl.obolibrary.org/obo/HP_0002040		hposlim_core
PATO:0002094	biolink:NamedThing	basophilic	An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for basic dyes under specific pH conditions.		hp.json		http://purl.obolibrary.org/obo/PATO_0002094		disposition_slim|value_slim|mpath_slim
HP:0002043	biolink:PhenotypicFeature	Esophageal stricture	A pathological narrowing of the esophagus that is caused by the development of a ring of scar tissue that constricts the esophageal lumen.	MSH:D004940|UMLS:C0014866|SNOMEDCT_US:63305008	hp.json	Narrowing of esophagus due to inflammation and scar tissue|Narrowing of oesophagus due to inflammation and scar tissue	http://purl.obolibrary.org/obo/HP_0002043		
HP:0002044	biolink:PhenotypicFeature	Zollinger-Ellison syndrome	A condition in which there is increased production of gastrin by a gastrin-secreting tumor (usually located in the pancreas, duodenum, or abdominal lymph nodes) that stimulates the gastric mucosa to maximal activity, with consequent gastrointestinal mucosal ulceration.	MEDDRA:10048281|SNOMEDCT_US:53132006|MSH:D015043|UMLS:C0043515	hp.json		http://purl.obolibrary.org/obo/HP_0002044		hposlim_core
HP:0002041	biolink:PhenotypicFeature	Intractable diarrhea		UMLS:C0743178	hp.json	Intractable diarrhoea	http://purl.obolibrary.org/obo/HP_0002041		
PATO:0002093	biolink:NamedThing	ballooning	A volume quality inhering in a degenerating cell by virtue of the bearer's exhibiting an increase in volume associated with cytoplasmic abnormalities.		hp.json		http://purl.obolibrary.org/obo/PATO_0002093		value_slim|mpath_slim
GO:0007519	biolink:BiologicalProcess	skeletal muscle tissue development	The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.		hp.json	myogenesis	http://purl.obolibrary.org/obo/GO_0007519		
GO:0007517	biolink:BiologicalProcess	muscle organ development	The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.		hp.json		http://purl.obolibrary.org/obo/GO_0007517		
UBERON:0004538	biolink:AnatomicalEntity	left kidney	A kidney that is part of a left side of organism [Automatically generated definition].	UMLS:C0227614|EMAPA:36589|FMA:7205|MA:0001655|NCIT:C34006	hp.json		http://purl.obolibrary.org/obo/UBERON_0004538		pheno_slim
UBERON:0004539	biolink:AnatomicalEntity	right kidney	A kidney that is part of a right side of organism [Automatically generated definition].	NCIT:C34005|MA:0001683|EMAPA:36590|UMLS:C0227613|FMA:7204	hp.json		http://purl.obolibrary.org/obo/UBERON_0004539		pheno_slim
UBERON:0016525	biolink:AnatomicalEntity	frontal lobe	Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border.	HBA:4009|EV:0100167|BAMS:Frontal_lobe|NCIT:C12352|UMLS:C0016733|BM:Tel-Cx-FR|CALOHA:TS-0389|BIRNLEX:928|MAT:0000505|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=56|FMA:61824|EFO:0000913|UMLS:C1268977|OpenCyc:Mx4rv3OJ8JwpEbGdrcN5Y29ycA|MESH:D005625|DHBA:12113|UMLS:C0016733	hp.json	lobi frontales|frontal region|regio frontalis|frontal cortex|regio frontalis|lobus frontalis	http://purl.obolibrary.org/obo/UBERON_0016525		human_reference_atlas|efo_slim
UBERON:0016527	biolink:AnatomicalEntity	white matter of cerebral lobe		FMA:256176	hp.json		http://purl.obolibrary.org/obo/UBERON_0016527		
UBERON:0016526	biolink:AnatomicalEntity	lobe of cerebral hemisphere	Subdivision of telencephalon which is one of a number of subdivisions of each hemisphere separated by both real landmarks (sulci and fissures) and arbitrary boundaries[FMA,modified].	BTO:0000445|FMA:61823|BIRNLEX:922	hp.json	lobe parts of cerebral cortex|lobe of cerebral cortex|segment of cerebral cortex|cerebral hemisphere lobe|lobes of the brain|cerebral lobe|lobi cerebri|cerebral cortical segment|regional organ part of cerebral cortex	http://purl.obolibrary.org/obo/UBERON_0016526		
UBERON:0016520	biolink:AnatomicalEntity	epithelium of female urethra	An epithelium that is part of a female urethra.	EMAPA:30470|FMA:19774	hp.json	urethral epithelium of female|female urethral epithelium	http://purl.obolibrary.org/obo/UBERON_0016520		
UBERON:0016522	biolink:AnatomicalEntity	cavity of right atrium	Luminal space of the right atrium of the heart.	FMA:11359|EMAPA:26020	hp.json	right atrial cavity	http://purl.obolibrary.org/obo/UBERON_0016522		
PATO:0002021	biolink:NamedThing	conical	A convex 3-D shape quality inhering in a bearer by virtue of the bearer's resembling a cone (a 3-D shape with a round cross section that tapers).	Image:http://upload.wikimedia.org/wikipedia/commons/d/d2/Cone_3d.png	hp.json	cone-shaped	http://purl.obolibrary.org/obo/PATO_0002021		value_slim
CHEBI:33595	biolink:ChemicalSubstance	cyclic compound	Any molecule that consists of a series of atoms joined together to form a ring.	Wikipedia:Cyclic_compound	hp.json	cyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33595		3_STAR
CHEBI:57560	biolink:ChemicalSubstance	long-chain fatty acid anion	A fatty acid anion with a chain length of C13 to C22.		hp.json	a long-chain fatty acid|long-chain fatty acid anions|a long-chain carboxylate	http://purl.obolibrary.org/obo/CHEBI_57560		3_STAR
CHEBI:33597	biolink:ChemicalSubstance	homocyclic compound	A cyclic compound having as ring members atoms of the same element only.		hp.json	homocyclic compounds|homocyclic compound|isocyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33597		3_STAR
CHEBI:33598	biolink:ChemicalSubstance	carbocyclic compound	A homocyclic compound in which all of the ring members are carbon atoms.		hp.json	carbocyclic compound|carbocycle|carbocyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33598		3_STAR
PATO:0002026	biolink:NamedThing	non-progressive	A quality of a single process inhering in a bearer by virtue of the bearer's not increasing over time.		hp.json		http://purl.obolibrary.org/obo/PATO_0002026		value_slim|mpath_slim|hpo_slim
UBERON:0016517	biolink:AnatomicalEntity	lumen of jejunum	An anatomical space that is part of a jejunum.	FMA:14590|EMAPA:18729	hp.json	jejunal lumen|jejunum lumen	http://purl.obolibrary.org/obo/UBERON_0016517		
UBERON:0004548	biolink:AnatomicalEntity	left eye	An eye that is part of a left side of organism [Automatically generated definition].	FMA:12515|MA:0002949|NCIT:C119334|SCTID:362503005|EMAPA:37362	hp.json	left orbital part of face|left eyeball|left orbital region	http://purl.obolibrary.org/obo/UBERON_0004548		pheno_slim
UBERON:0004544	biolink:AnatomicalEntity	epididymis epithelium	The layer of secretory cells which lines the epididymis.	MA:0002825|CALOHA:TS-2063|EMAPA:30445|BTO:0005768|FMA:19153	hp.json	epididymis epithelium|epithelium of epididymis	http://purl.obolibrary.org/obo/UBERON_0004544		pheno_slim
GO:0007528	biolink:BiologicalProcess	neuromuscular junction development	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.		hp.json	NMJ stability|neuromuscular junction stability|neuromuscular junction organization	http://purl.obolibrary.org/obo/GO_0007528		
UBERON:0004529	biolink:AnatomicalEntity	anatomical projection	A projection or outgrowth of tissue from a larger body or organ.	galen:Ridge|VSAO:0000180|AAO:0010278|FMA:67601|XAO:0004020|NCIT:C61549|HAO:0000822|TAO:0001834	hp.json	spine|flange|laminae|processes|papilla|process|projection|protrusion|ridge|ridges|shelves|anatomical protrusion|anatomical process|shelf|organ process|projections|flanges|lamellae|lamina|lamella|processus|projection|process of organ	http://purl.obolibrary.org/obo/UBERON_0004529		upper_level
UBERON:0004527	biolink:AnatomicalEntity	alveolar process of maxilla	The thickened ridge of bone that contains the tooth sockets on the maxilla.	FMA:52897|MA:0001492|AAO:0000396	hp.json	alveolar margin of maxilla|alveolar process of maxilla|maxilla alveolar process|processus alveolaris (maxilla)|alveolar part of maxilla|pars dentalis of maxilla|posterior alveolar ridge|processus alveolaris maxillae|lower alveolar ridge|alveolar ridge of maxilla	http://purl.obolibrary.org/obo/UBERON_0004527		pheno_slim
UBERON:0004528	biolink:AnatomicalEntity	alveolar ridge of mandible	The thickened ridge of bone that contains the tooth sockets on the mandible.	FMA:52832	hp.json	anterior alveolar ridge|alveolar margin of mandible|alveolar arch of mandible|alveolar process of mandible|pars alveolaris mandibulae|pars alveolaris (mandibula)|upper alveolar ridge|alveolar part of mandible	http://purl.obolibrary.org/obo/UBERON_0004528		pheno_slim
HP:0004608	biolink:PhenotypicFeature	Anteriorly placed odontoid process	Anterior mislocalization of the dens of the axis.	UMLS:C1844512	hp.json		http://purl.obolibrary.org/obo/HP_0004608		
UBERON:0016514	biolink:AnatomicalEntity	cavity of left ventricle	Luminal space of the left ventricle of the heart.	EMAPA:26038|FMA:9466	hp.json	left ventricular cavity	http://purl.obolibrary.org/obo/UBERON_0016514		
HP:0004607	biolink:PhenotypicFeature	Anterior beaking of lower thoracic vertebrae	Anterior tongue-like protrusions of the lower thoracic vertebral bodies.	UMLS:C4025306	hp.json		http://purl.obolibrary.org/obo/HP_0004607		
UBERON:0016513	biolink:AnatomicalEntity	cavity of left atrium	Luminal space of the left atrium of the heart.	EMAPA:26011|FMA:9465	hp.json	left atrial cavity|left atrium lumen	http://purl.obolibrary.org/obo/UBERON_0016513		
HP:0004606	biolink:PhenotypicFeature	Unossified vertebral bodies	A lack of ossification of the vertebral bodies.	UMLS:C1860202	hp.json		http://purl.obolibrary.org/obo/HP_0004606		
PATO:0002039	biolink:NamedThing	biconcave	A concave quality inhering in a bearer by virtue of the bearer's curving inward on both sides or surfaces.		hp.json		http://purl.obolibrary.org/obo/PATO_0002039		value_slim
HP:0004605	biolink:PhenotypicFeature	Absent vertebral body mineralization	A lack of bone mineralization of the vertebral bodies.	UMLS:C1860191	hp.json		http://purl.obolibrary.org/obo/HP_0004605		
UBERON:0016510	biolink:AnatomicalEntity	epithelium of male urethra	An epithelium that is part of a male urethra.	EMAPA:30467|FMA:19684	hp.json	urethral epithelium of male|male urethral epithelium	http://purl.obolibrary.org/obo/UBERON_0016510		
UBERON:0016512	biolink:AnatomicalEntity	lumen of duodenum	An anatomical space that is part of a duodenum.	FMA:14589|EMAPA:19080	hp.json	doudenal lumen|duodenal lumen	http://purl.obolibrary.org/obo/UBERON_0016512		
HP:0004609	biolink:PhenotypicFeature	Patchy distortion of vertebrae		UMLS:C4025305	hp.json		http://purl.obolibrary.org/obo/HP_0004609		
PATO:0002037	biolink:NamedThing	degeneration	A structural quality inhering in a bearer by virtue of the bearer exhibiting deterioration of its structure.		hp.json		http://purl.obolibrary.org/obo/PATO_0002037		scalar_slim|attribute_slim
GO:0140297	biolink:MolecularActivity	DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.		hp.json	transcription activator binding|activating transcription factor binding|repressing transcription factor binding	http://purl.obolibrary.org/obo/GO_0140297		
HP:0004603	biolink:PhenotypicFeature	Hyperconvex vertebral body endplates		UMLS:C4025307	hp.json		http://purl.obolibrary.org/obo/HP_0004603		
HP:0004602	biolink:PhenotypicFeature	Cervical C2/C3 vertebral fusion	Fusion of cervical vertebrae at C2 and C3, caused by a failure in the normal segmentation or division of the cervical vertebrae during the early weeks of fetal development, leading to a short neck with a low hairline at the back of the head, and restricted mobility of the upper spine.	SNOMEDCT_US:5601008|MSH:D007714|SNOMEDCT_US:388981000|UMLS:C0022738	hp.json	Klippel-Feil syndrome|Fusion of cervical vertebrae c2-3|Klippel-Feil anomaly	http://purl.obolibrary.org/obo/HP_0004602		
PATO:0002034	biolink:NamedThing	undivided	A shape quality inhering in a bearer by virtue of the bearer's being unseparated into parts or divisions.		hp.json	unseparated	http://purl.obolibrary.org/obo/PATO_0002034		value_slim
UBERON:0016509	biolink:AnatomicalEntity	cavity of right ventricle	Luminal space of the right ventricle of the heart.	FMA:9291|EMAPA:26047	hp.json	right ventricle lumen|right ventricular cavity	http://purl.obolibrary.org/obo/UBERON_0016509		
HP:0004601	biolink:PhenotypicFeature	Spina bifida occulta at L5	The closed form of spina bifida with incomplete closure of the vertebra L5 with intact overlying skin.	UMLS:C4025308	hp.json		http://purl.obolibrary.org/obo/HP_0004601		
UBERON:0004536	biolink:AnatomicalEntity	lymph vasculature	A network of blunt ended vessels lacking direct connection to the blood vascular system. These vessels collect and drain fluids and macromolecules from interstitial spaces throughout the animal. They derive from a subpopulation of endothelial cells and have walls that are much thinner than the blood carrying vessels. Lymphatic vessels are usually classified as either superficial or deep.	TAO:0005105|FMA:63815|ZFA:0005105	hp.json	lymphatic vasculature|lymphatic vessels set|set of lymphatic vessels|lymphatic trunks and ducts|trunci et ductus lymphatici|lymphatic vessel network|lymph vessels	http://purl.obolibrary.org/obo/UBERON_0004536		human_reference_atlas|vertebrate_core
UBERON:0004537	biolink:AnatomicalEntity	blood vasculature	A vascular network consisting of blood vessels.	TAO:0001079|ZFA:0001079	hp.json	blood vessels|blood vascular network|blood system|blood vessel system|set of blood vessels	http://purl.obolibrary.org/obo/UBERON_0004537		human_reference_atlas
UBERON:0004534	biolink:AnatomicalEntity	right testis	A testis that is in the right side of the genitalia [Automatically generated definition].	OpenCyc:Mx4rvVjM25wpEbGdrcN5Y29ycA|UMLS:C0227997|MA:0001747|EMAPA:37371|FMA:7211|NCIT:C49326	hp.json	right testicle	http://purl.obolibrary.org/obo/UBERON_0004534		
UBERON:0004535	biolink:AnatomicalEntity	cardiovascular system	Anatomical system that has as its parts the heart and blood vessels.	MA:0000010|UMLS:C0007226|MIAA:0000016|BILA:0000016|TAO:0000010|EMAPA:16370|AAO:0011001|VHOG:0000302|FMA:7161|EHDAA:394|BTO:0000088|EFO:0000791|GAID:467|MESH:D002319|WikipediaCategory:Cardiovascular_system|OpenCyc:Mx4rvVjzG5wpEbGdrcN5Y29ycA|EMAPA:16104|SCTID:278198007|EHDAA2:0000216|XAO:0000100|CALOHA:TS-1297|EV:0100017|MAT:0000016|XAO:0001010|NCIT:C12686|ZFA:0000010	hp.json	CV system|Herz und Gefaesssystem	http://purl.obolibrary.org/obo/UBERON_0004535		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0004533	biolink:AnatomicalEntity	left testis	A testis that is in the left side of the genitalia [Automatically generated definition].	NCIT:C49323|MA:0001746|EMAPA:37370|FMA:7212|UMLS:C0227998	hp.json	left testicle	http://purl.obolibrary.org/obo/UBERON_0004533		
UBERON:0004530	biolink:AnatomicalEntity	bony projection	Anatomical projection that is composed of bone tissue.	FMA:75433|ZFA:0001637	hp.json	bone process|projection of bone|bony projections	http://purl.obolibrary.org/obo/UBERON_0004530		vertebrate_core
UBERON:0004518	biolink:AnatomicalEntity	muscle of vertebral column	A muscle that is attached to a vertebra of the vertebral column.	FMA:22594	hp.json	vertebral column muscle	http://purl.obolibrary.org/obo/UBERON_0004518		
UBERON:0004519	biolink:AnatomicalEntity	muscle of anal triangle	Any muscle organ that is part of a anal part of perineum.	FMA:77304	hp.json	anal triangle muscle	http://purl.obolibrary.org/obo/UBERON_0004519		
UBERON:0004516	biolink:AnatomicalEntity	smooth muscle tissue of terminal bronchiole	A portion of smooth muscle tissue that is part of a terminal bronchiole [Automatically generated definition].	FMA:261051	hp.json		http://purl.obolibrary.org/obo/UBERON_0004516		human_reference_atlas
PATO:0002049	biolink:NamedThing	lateral and rotional curvature	A curvature quality inhering in a bearer by virtue of the bearer's being curved around an axis and towards the side.		hp.json		http://purl.obolibrary.org/obo/PATO_0002049		value_slim
PATO:0002043	biolink:NamedThing	increased anterior-posterior diameter	An anterior-posterior diameter quality which is relatively large.		hp.json	high anterior-posterior diameter	http://purl.obolibrary.org/obo/PATO_0002043		value_slim
PATO:0002044	biolink:NamedThing	trapezoid	A shape quality inhering in a bearer by virtue of the bearer's being a quadrilateral with two parallel sides.		hp.json	trapezoidal	http://purl.obolibrary.org/obo/PATO_0002044		value_slim
PATO:0002041	biolink:NamedThing	anterior-posterior diameter	A diameter that is along the anterior-posterior axis.		hp.json		http://purl.obolibrary.org/obo/PATO_0002041		scalar_slim|attribute_slim
CHEBI:33575	biolink:ChemicalSubstance	carboxylic acid	A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid.	Wikipedia:Carboxylic_acid|PMID:18433345|PMID:17147560	hp.json	Karbonsaeure|Carbonsaeuren|acido carboxilico|Carbonsaeure|acides carboxyliques|carboxylic acids|acide carboxylique|carboxylic acid|RC(=O)OH|acidos carboxilicos	http://purl.obolibrary.org/obo/CHEBI_33575		3_STAR
PATO:0002042	biolink:NamedThing	decreased anterior-posterior diameter	An anterior-posterior diameter quality which is relatively small.		hp.json	low anterior-posterior diameter	http://purl.obolibrary.org/obo/PATO_0002042		value_slim
CHEBI:33576	biolink:ChemicalSubstance	sulfur-containing carboxylic acid	Any carboxylic acid having a sulfur substituent.		hp.json	S-containing carboxylic acids|S-containing carboxylic acid|sulfur-containing carboxylic acids	http://purl.obolibrary.org/obo/CHEBI_33576		3_STAR
PATO:0002045	biolink:NamedThing	dendritic	A branched quality inhering in a bearer by virtue of the bearer's having smaller branches arising from larger branches. Resembling a tree in branching structure.		hp.json	dendriform|dendroid|dendroidal	http://purl.obolibrary.org/obo/PATO_0002045		value_slim
CHEBI:33579	biolink:ChemicalSubstance	main group molecular entity	A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table.		hp.json	main group compounds|main group molecular entities	http://purl.obolibrary.org/obo/CHEBI_33579		3_STAR
UBERON:0004521	biolink:AnatomicalEntity	vasculature of muscle organ	A vasculature that is part of a muscle organ [Automatically generated definition].	FMA:87123	hp.json	muscular organ vasculature	http://purl.obolibrary.org/obo/UBERON_0004521		
UBERON:0004522	biolink:AnatomicalEntity	vasculature of musculoskeletal system	A vasculature that is part of a musculoskeletal system [Automatically generated definition].	FMA:239607	hp.json		http://purl.obolibrary.org/obo/UBERON_0004522		
PATO:0002040	biolink:NamedThing	biconvex	A shape quality inhering in a bearer by virtue of the bearer's being convex on both sides or surface.	Image:http://www.thefreedictionary.com/_/viewer.aspx?path=hm&name=A4bicovx	hp.json		http://purl.obolibrary.org/obo/PATO_0002040		value_slim
CHEBI:33570	biolink:ChemicalSubstance	benzenediols			hp.json		http://purl.obolibrary.org/obo/CHEBI_33570		3_STAR
UBERON:0004520	biolink:AnatomicalEntity	striated muscle tissue of prostate	A portion of striated muscle tissue that is part of a prostate gland [Automatically generated definition].	FMA:45716	hp.json		http://purl.obolibrary.org/obo/UBERON_0004520		
GO:0007507	biolink:BiologicalProcess	heart development	The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.	Wikipedia:Heart_development	hp.json	cardiac development|dorsal vessel development	http://purl.obolibrary.org/obo/GO_0007507		
UBERON:0004509	biolink:AnatomicalEntity	skeletal muscle tissue of trapezius	A portion of skeletal muscle tissue that is part of a trapezius [Automatically generated definition].	FMA:261938	hp.json	skeletal muscle tissue of trapezius muscle	http://purl.obolibrary.org/obo/UBERON_0004509		
GO:0007506	biolink:BiologicalProcess	gonadal mesoderm development	The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.		hp.json		http://purl.obolibrary.org/obo/GO_0007506		
UBERON:0004507	biolink:AnatomicalEntity	skeletal muscle tissue of temporalis	A portion of skeletal muscle tissue that is part of a temporalis [Automatically generated definition].	FMA:261740	hp.json		http://purl.obolibrary.org/obo/UBERON_0004507		
UBERON:0004508	biolink:AnatomicalEntity	skeletal muscle tissue of levator palpebrae superioris	A portion of skeletal muscle tissue that is part of a levator palpebrae superioris [Automatically generated definition].	FMA:261782	hp.json		http://purl.obolibrary.org/obo/UBERON_0004508		
UBERON:0004505	biolink:AnatomicalEntity	skeletal muscle tissue of orbicularis oculi	A portion of skeletal muscle tissue that is part of a orbicularis oculi [Automatically generated definition].	FMA:261812	hp.json		http://purl.obolibrary.org/obo/UBERON_0004505		
UBERON:0004506	biolink:AnatomicalEntity	skeletal muscle tissue of masseter	A portion of skeletal muscle tissue that is part of a masseter [Automatically generated definition].	FMA:261824	hp.json		http://purl.obolibrary.org/obo/UBERON_0004506		
CHEBI:45557	biolink:ChemicalSubstance	sec-butyl group		PDBeChem:NBU	hp.json	isoleucine side-chain|1-methylpropyl|-CH(CH3)-CH2-CH3|CH3-CH2-CH(CH3)-|butan-2-yl|SEC-BUTYL GROUP|butan-2-ido|sec-butyl|s-butyl|but-2-yl	http://purl.obolibrary.org/obo/CHEBI_45557		3_STAR
PATO:0002055	biolink:NamedThing	increased fragility	A fragility which is relatively high.		hp.json		http://purl.obolibrary.org/obo/PATO_0002055		disposition_slim|value_slim
PATO:0002052	biolink:NamedThing	decreased occurrence	An occurrence which is relatively low.		hp.json	decreased incidence	http://purl.obolibrary.org/obo/PATO_0002052		
PATO:0002056	biolink:NamedThing	decreased fragility	A fragility which is relatively low.		hp.json		http://purl.obolibrary.org/obo/PATO_0002056		disposition_slim|value_slim
UBERON:0004515	biolink:AnatomicalEntity	smooth muscle tissue of bronchiole	A portion of smooth muscle tissue that is part of a bronchiole [Automatically generated definition].	FMA:261081|FMA:261045	hp.json	smooth muscle tissue of lobular bronchiole	http://purl.obolibrary.org/obo/UBERON_0004515		
UBERON:0004510	biolink:AnatomicalEntity	skeletal muscle tissue of pectoralis major	A portion of skeletal muscle tissue that is part of a pectoralis major [Automatically generated definition].	FMA:261968	hp.json	skeletal muscle tissue of pectoralis major muscle	http://purl.obolibrary.org/obo/UBERON_0004510		
PATO:0002051	biolink:NamedThing	increased occurrence	An occurrence which is relatively high.		hp.json	increased incidence	http://purl.obolibrary.org/obo/PATO_0002051		
UBERON:0004511	biolink:AnatomicalEntity	skeletal muscle tissue of rectus abdominis	A portion of skeletal muscle tissue that is part of a rectus abdominis [Automatically generated definition].	FMA:261924	hp.json		http://purl.obolibrary.org/obo/UBERON_0004511		
CHEBI:33582	biolink:ChemicalSubstance	carbon group molecular entity			hp.json	carbon group molecular entity|carbon group molecular entities	http://purl.obolibrary.org/obo/CHEBI_33582		3_STAR
CHEBI:33558	biolink:ChemicalSubstance	alpha-amino-acid anion	An amino-acid anion obtained by deprotonation of any alpha-amino acid.		hp.json	alpha-amino-acid anion|alpha-amino acid anions|alpha-amino-acid anions	http://purl.obolibrary.org/obo/CHEBI_33558		3_STAR
CHEBI:33559	biolink:ChemicalSubstance	s-block element atom			hp.json	s-block elements|s-block element	http://purl.obolibrary.org/obo/CHEBI_33559		3_STAR
HP:0004639	biolink:PhenotypicFeature	Elevated amniotic fluid alpha-fetoprotein	An elevation of alpha-feto protein measured in the amniotic fluid.	UMLS:C1839860	hp.json	Elevated amniotic fluid alpha fetal protein|Elevated amniotic fluid alpha-fetoglobulin|Elevated amniotic fluid alpha-1-fetoprotein|Elevated amniotic fluid alpha foetal protein	http://purl.obolibrary.org/obo/HP_0004639		
UBERON:0016565	biolink:AnatomicalEntity	cerebral blood vessel	A blood vessel that is part of a cerebellum.		hp.json		http://purl.obolibrary.org/obo/UBERON_0016565		
UBERON:0016566	biolink:AnatomicalEntity	pit	An roughly circular indentation in a surface.	AEO:0000204	hp.json		http://purl.obolibrary.org/obo/UBERON_0016566		upper_level
HP:0004633	biolink:PhenotypicFeature	Lower thoracic kyphosis	Over curvature of the lower thoracic region, leading to a round back or if sever to a hump.	UMLS:C1864361	hp.json	Round mid-back	http://purl.obolibrary.org/obo/HP_0004633		
CHEBI:33551	biolink:ChemicalSubstance	organosulfonic acid	An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon.		hp.json	sulfonic acids|organosulfonic acids	http://purl.obolibrary.org/obo/CHEBI_33551		3_STAR
HP:0004632	biolink:PhenotypicFeature	Cervical segmentation defect	An abnormality related to a defect of vertebral separation of cervical vertebrae during development.	UMLS:C1862415	hp.json	Cervical spine segmentation defect	http://purl.obolibrary.org/obo/HP_0004632		
UBERON:0004581	biolink:AnatomicalEntity	systemic venous system	The part of the venous system that drains the general body tissues[Kardong].	Wikipedia:Systemic_venous_system|FMA:45626	hp.json	systemic venous circulatory system	http://purl.obolibrary.org/obo/UBERON_0004581		
HP:0004631	biolink:PhenotypicFeature	Decreased cervical spine flexion due to contractures of posterior cervical muscles		UMLS:C4280512|UMLS:C1839653	hp.json	Contracture of post-cervical muscles|Inability to touch chin to chest	http://purl.obolibrary.org/obo/HP_0004631		
CHEBI:33552	biolink:ChemicalSubstance	sulfonic acid derivative			hp.json	sulfonic acid derivatives|sulfonic acid derivative|derivatives of sulfonic acid	http://purl.obolibrary.org/obo/CHEBI_33552		3_STAR
UBERON:0004582	biolink:AnatomicalEntity	venous system	The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions.	BTO:0004692|SCTID:362060003|MA:0002720|EMAPA:16240|EHDAA:486|UMLS:C1267406|VHOG:0000277|NCIT:C33858|EHDAA2:0002171	hp.json	vein system	http://purl.obolibrary.org/obo/UBERON_0004582		
HP:0004630	biolink:PhenotypicFeature	Anterior beaking of thoracic vertebrae	Anterior tongue-like protrusions of thoracic vertebral bodies.	UMLS:C4025302	hp.json		http://purl.obolibrary.org/obo/HP_0004630		
HP:0004637	biolink:PhenotypicFeature	Decreased cervical spine mobility		UMLS:C1859692	hp.json	Limited neck movement	http://purl.obolibrary.org/obo/HP_0004637		
CHEBI:33554	biolink:ChemicalSubstance	organosulfonate oxoanion	An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid.		hp.json	organosulfonate|organosulfonate oxoanions|organosulfonates	http://purl.obolibrary.org/obo/CHEBI_33554		3_STAR
HP:0004635	biolink:PhenotypicFeature	Cervical C5/C6 vertebrae fusion	Fusion of the C5 and C6 cervical vertebrae.	UMLS:C4025301	hp.json		http://purl.obolibrary.org/obo/HP_0004635		
HP:0004634	biolink:PhenotypicFeature	Cuboid-shaped vertebral bodies		UMLS:C2673653	hp.json	Cuboid vertebral bodies	http://purl.obolibrary.org/obo/HP_0004634		
UBERON:0016550	biolink:AnatomicalEntity	spinal cord column			hp.json		http://purl.obolibrary.org/obo/UBERON_0016550		
UBERON:0016552	biolink:AnatomicalEntity	phlegm	Mucus produced in the respiratory tract.	NCIT:C93171|UMLS:C0225378	hp.json		http://purl.obolibrary.org/obo/UBERON_0016552		
UBERON:0016551	biolink:AnatomicalEntity	subdivision of spinal cord ventral column			hp.json		http://purl.obolibrary.org/obo/UBERON_0016551		non_informative
CHEBI:33569	biolink:ChemicalSubstance	noradrenaline	A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted.	Gmelin:863925|Beilstein:2210994|CAS:138-65-8|LINCS:LSM-5181|CAS:138-65-8	hp.json	4-(2-amino-1-hydroxyethyl)benzene-1,2-diol|noradrenalina|norepinephrine	http://purl.obolibrary.org/obo/CHEBI_33569		3_STAR
UBERON:0016554	biolink:AnatomicalEntity	white matter of midbrain	A white matter that is part of the midbrain.	HBA:265505382|FMA:83936|DHBA:10650	hp.json	mesencephalic white matter	http://purl.obolibrary.org/obo/UBERON_0016554		human_reference_atlas
UBERON:0016553	biolink:AnatomicalEntity	respiratory system mucus	Any mucus produced by a mucosae of the respiratory system. This includes the mucus produced in the nasal cavity (nasal mucus) and mucus produced in the respiratory tract (phlegm).		hp.json		http://purl.obolibrary.org/obo/UBERON_0016553		
UBERON:0004572	biolink:AnatomicalEntity	arterial system	The part of the cardiovascular system consisting of all arteries.	SCTID:362030008|EMAPA:16201|VHOG:0000273|BTO:0004690|EMAPA:16371|EHDAA2:0000143|MA:0002719|EHDAA:396	hp.json		http://purl.obolibrary.org/obo/UBERON_0004572		pheno_slim
CHEBI:33561	biolink:ChemicalSubstance	d-block element atom			hp.json	d-block elements|d-block element	http://purl.obolibrary.org/obo/CHEBI_33561		3_STAR
UBERON:0004573	biolink:AnatomicalEntity	systemic artery	An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart.	EMAPA:37126|Wikipedia:Artery#Systemic_arteries|FMA:66464	hp.json	systemic arterial subtree	http://purl.obolibrary.org/obo/UBERON_0004573		pheno_slim
CHEBI:33563	biolink:ChemicalSubstance	glycolipid	Any member of class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar part acylated by one or more fatty acids and the glycerol part may be absent.	Wikipedia:Glycolipids|KEGG:C05005	hp.json	glycolipids|Glycolipid	http://purl.obolibrary.org/obo/CHEBI_33563		3_STAR
UBERON:0004571	biolink:AnatomicalEntity	systemic arterial system	The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart.	Wikipedia:Systemic_circulation#Arteries|FMA:45623	hp.json	systemic arterial circulatory system	http://purl.obolibrary.org/obo/UBERON_0004571		pheno_slim
GO:0140253	biolink:BiologicalProcess	cell-cell fusion	A cellular process in which two or more cells combine together, their plasma membrane fusing, producing a single cell. In some cases, nuclei fuse, producing a polyploid cell, while in other cases, nuclei remain separate, producing a syncytium.		hp.json	cell fusion|cell cell fusion	http://purl.obolibrary.org/obo/GO_0140253		
CHEBI:33566	biolink:ChemicalSubstance	catechols	Any compound containing an o-diphenol component.	KEGG:C15571	hp.json	a catechol|benzene-1,2-diols|1,2-benzenediols	http://purl.obolibrary.org/obo/CHEBI_33566		3_STAR
HP:0004646	biolink:PhenotypicFeature	Hypoplasia of the nasal bone	Underdevelopment of the nasal bone.	UMLS:C4021651	hp.json	Hypotrophic nasal bone|Decreased size of nasal bone|Deficiency of nasal bone|Small nasal bone|Nasal bone hypoplasia|Underdevelopment of nasal bone	http://purl.obolibrary.org/obo/HP_0004646		
CHEBI:33567	biolink:ChemicalSubstance	catecholamine	4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.	KEGG:C02012	hp.json	catecholamines|catecholamines|Catecholamine	http://purl.obolibrary.org/obo/CHEBI_33567		3_STAR
CHEBI:33568	biolink:ChemicalSubstance	adrenaline	A catecholamine in which the aminoethyl side-chain is hydroxy-substituted at C-1 and methylated on nitrogen.	PMID:24252294|PMID:24719616|LINCS:LSM-4958|Drug_Central:4508|Gmelin:51559|PMID:10052027|Beilstein:2212160|Reaxys:2212160|CAS:329-65-7	hp.json	4-[1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol|racepinefrina|dl-adrenaline|2-(methylamino)-1-(3,4-dihydroxyphenyl)ethanol|epinephrine racemic|racepinefrinum|(+-)-epinephrine|(+-)-adrenaline|racepinefrine	http://purl.obolibrary.org/obo/CHEBI_33568		3_STAR
CHEBI:33560	biolink:ChemicalSubstance	p-block element atom	Any main group element atom belonging to the p-block of the periodic table.		hp.json	p-block element|p-block elements	http://purl.obolibrary.org/obo/CHEBI_33560		3_STAR
PATO:0002007	biolink:NamedThing	convex 3-D shape	A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave.	Image:http://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png	hp.json		http://purl.obolibrary.org/obo/PATO_0002007		attribute_slim
HP:0004619	biolink:PhenotypicFeature	Lumbar kyphoscoliosis		UMLS:C1834953	hp.json		http://purl.obolibrary.org/obo/HP_0004619		
PATO:0002008	biolink:NamedThing	concave 3-D shape	A complete three dimensional shape in which there is a line connecting pair of points on the object that lies outside the object. Or: a shape with cavities. Contrast: concave.	Image:http://en.wikipedia.org/wiki/Image:Convex_polygon_illustration2.png	hp.json		http://purl.obolibrary.org/obo/PATO_0002008		attribute_slim
HP:0004618	biolink:PhenotypicFeature	Sandwich appearance of vertebral bodies		UMLS:C1850134	hp.json		http://purl.obolibrary.org/obo/HP_0004618		
UBERON:0016549	biolink:AnatomicalEntity	central nervous system white matter layer	A layer of of the central nervous system that is composed of white matter.	FMA:83898	hp.json	CNS white matter layer|white matter layer|white matter layer of neuraxis	http://purl.obolibrary.org/obo/UBERON_0016549		
HP:0004617	biolink:PhenotypicFeature	Butterfly vertebral arch	Butterfly vertebrae have a cleft through the body of the vertebrae and a funnel shape at the ends.	UMLS:C1861627	hp.json		http://purl.obolibrary.org/obo/HP_0004617		
PATO:0002005	biolink:NamedThing	concavity	Surface shape that refers to the inward or outward curvature of the surface.		hp.json		http://purl.obolibrary.org/obo/PATO_0002005		attribute_slim
PATO:0002006	biolink:NamedThing	2-D shape	A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity.		hp.json	2-D projection|cross-sectional	http://purl.obolibrary.org/obo/PATO_0002006		attribute_slim
UBERON:0016548	biolink:AnatomicalEntity	central nervous system gray matter layer	A layer of of the central nervous system that is part of gray matter.	FMA:83142	hp.json	CNS gray matter layer|grey matter layer of neuraxis|gray matter layer of neuraxis|CNS grey matter layer|grey matter layer	http://purl.obolibrary.org/obo/UBERON_0016548		
HP:0004616	biolink:PhenotypicFeature	Cleft vertebral arch	A discontinuity of the vertebral arch, i.e., of the posterior part of a vertebra.	UMLS:C1859458	hp.json	Cleft vertebral arches	http://purl.obolibrary.org/obo/HP_0004616		
UBERON:0016542	biolink:AnatomicalEntity	limbic cortex		FMA:242234	hp.json	cortex of limbic lobe|gray matter of limbic lobe|limbic lobe cortex	http://purl.obolibrary.org/obo/UBERON_0016542		
PATO:0002009	biolink:NamedThing	branchiness	A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0002009		attribute_slim|cell_quality
UBERON:0016545	biolink:AnatomicalEntity	pharyngeal ectoderm	The external part of the developing pharynx that is made of ectoderm. During vertebrate development, pockets form in pharyngeal ectoderm between the pharyngeal arches.	ZFA:0001379|TAO:0001379	hp.json		http://purl.obolibrary.org/obo/UBERON_0016545		
HP:0004611	biolink:PhenotypicFeature	Anterior concavity of thoracic vertebrae		UMLS:C1839822	hp.json	Anteriorly concave vertebrae	http://purl.obolibrary.org/obo/HP_0004611		
PATO:0002000	biolink:NamedThing	lacks all parts of type	A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity.	OBO_REL:lacks_part	hp.json	lacks all physical parts of type	http://purl.obolibrary.org/obo/PATO_0002000		relational_slim
HP:0004610	biolink:PhenotypicFeature	Lumbar spinal canal stenosis	An abnormal narrowing of the lumbar spinal canal.	UMLS:C0158288|SNOMEDCT_US:18347007	hp.json	Lumbar spinal stenosis|Narrow lumbar spinal canal	http://purl.obolibrary.org/obo/HP_0004610		
HP:0004614	biolink:PhenotypicFeature	Spina bifida occulta at S1	The closed form of spina bifida with incomplete closure of S1 with intact overlying skin.	UMLS:C4025304	hp.json		http://purl.obolibrary.org/obo/HP_0004614		
PATO:0002001	biolink:NamedThing	has fewer parts of type	The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly.		hp.json	has fewer physical parts of type|decreased number of|has decreased number of	http://purl.obolibrary.org/obo/PATO_0002001		relational_slim
PATO:0002002	biolink:NamedThing	has extra parts of type	The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part.		hp.json	has increased number of|having extra physical parts|having supernumerary physical parts|increased number of|has extra parts of	http://purl.obolibrary.org/obo/PATO_0002002		relational_slim
UBERON:0016530	biolink:AnatomicalEntity	parietal cortex	Gray matter of the parietal region of the neocortex, located in the parietal lobe of gyrencephalic animals. It is continuous anteriorly with the frontal cortex, posteriorly with the occipital cortex and medially with the insular cortex and with the temporal cortex on the posterior/inferior border.	DHBA:10208|DMBA:16016|NLX:79282|MA:0000916|EMAPA:35667|FMA:242203	hp.json	gray matter of parietal lobe|parietal lobe cortex|parietal neocortex|cortex of parietal lobe	http://purl.obolibrary.org/obo/UBERON_0016530		pheno_slim
UBERON:0004549	biolink:AnatomicalEntity	right eye	An eye that is part of a right side of organism [Automatically generated definition].	FMA:12514|NCIT:C119333|EMAPA:37363|SCTID:362502000|MA:0002950	hp.json	right eyeball|right orbital part of face|right orbital region	http://purl.obolibrary.org/obo/UBERON_0004549		pheno_slim
UBERON:0016536	biolink:AnatomicalEntity	white matter of limbic lobe	A white matter of cerebral lobe that is part of a limbic lobe.	FMA:261091	hp.json		http://purl.obolibrary.org/obo/UBERON_0016536		
HP:0004629	biolink:PhenotypicFeature	Small cervical vertebral bodies	Reduced size of cervical vertebrae.	UMLS:C1851130	hp.json	Small cervical vertebrae	http://purl.obolibrary.org/obo/HP_0004629		
UBERON:0016538	biolink:AnatomicalEntity	temporal cortex	Gray matter of the temporal region of the neocortex, located in the temporal lobe in gyrencephalic animals.	BM:Tel-Cx-Te|NLX:94939|FMA:242201|MA:0000941|DHBA:10235|DMBA:16044	hp.json	cortex of temporal lobe|gray matter of temporal lobe|temporal neocortex|temporal lobe cortex	http://purl.obolibrary.org/obo/UBERON_0016538		
UBERON:0016531	biolink:AnatomicalEntity	white matter of parietal lobe	A white matter of cerebral lobe that is part of a parietal lobe.	FMA:256184	hp.json		http://purl.obolibrary.org/obo/UBERON_0016531		
UBERON:0016534	biolink:AnatomicalEntity	white matter of temporal lobe	A white matter of cerebral lobe that is part of a temporal lobe.	FMA:256186	hp.json		http://purl.obolibrary.org/obo/UBERON_0016534		
HP:0004622	biolink:PhenotypicFeature	Progressive intervertebral space narrowing	A progressive form of decreased height of the intervertebral disk.	UMLS:C1837670	hp.json		http://purl.obolibrary.org/obo/HP_0004622		
PATO:0002011	biolink:NamedThing	neoplastic	A structural quality which is held by a bearer when the latter's disposition the presence of abnormally proliferating masses of cells.		hp.json	tumorous	http://purl.obolibrary.org/obo/PATO_0002011		value_slim|mpath_slim|disposition_slim
CHEBI:33540	biolink:ChemicalSubstance	thiosulfuric acid			hp.json	sulfurothioic acid|thiosulfuric acid	http://purl.obolibrary.org/obo/CHEBI_33540		3_STAR
HP:0004621	biolink:PhenotypicFeature	Enlarged vertebral pedicles	Increased size of the vertebral pedicle.	UMLS:C4025303	hp.json	Hyperplastic vertebral pedicles	http://purl.obolibrary.org/obo/HP_0004621		
CHEBI:33541	biolink:ChemicalSubstance	thiosulfate(1-)		KEGG:C00320	hp.json	HS2O3(-)|hydrogen sulfurothioate	http://purl.obolibrary.org/obo/CHEBI_33541		3_STAR
CHEBI:33543	biolink:ChemicalSubstance	sulfonate	The sulfur oxoanion formed by deprotonation of sulfonic acid.	Gmelin:971569	hp.json	hydridotrioxidosulfate(1-)|SHO3(-)|sulfonates|[SHO3](-)	http://purl.obolibrary.org/obo/CHEBI_33543		3_STAR
UBERON:0016529	biolink:AnatomicalEntity	cortex of cerebral lobe	Grey matter neocortex region of a lobe of the cerebral hemisphere.	FMA:242197	hp.json	neocortical part of cerebral hemisphere|cortex of lobe of cerebral hemisphere|gray matter of lobe of cerebral hemisphere|cortex of cerebral hemisphere lobe	http://purl.obolibrary.org/obo/UBERON_0016529		
PATO:0002014	biolink:NamedThing	structure, cavities	A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas.		hp.json		http://purl.obolibrary.org/obo/PATO_0002014		attribute_slim
HP:0004626	biolink:PhenotypicFeature	Lumbar scoliosis		UMLS:C2748518	hp.json		http://purl.obolibrary.org/obo/HP_0004626		
UBERON:0016528	biolink:AnatomicalEntity	white matter of frontal lobe	A white matter of cerebral lobe that is part of a frontal lobe.	FMA:256178	hp.json	frontal lobe white matter	http://purl.obolibrary.org/obo/UBERON_0016528		
HP:0004625	biolink:PhenotypicFeature	Biconvex vertebral bodies	Presence of abnormal convexity of the upper and lower end plates of the vertebrae, i.e., an exaggerated bulging out of the upper and lower vertebral end plates.	UMLS:C1866675	hp.json		http://purl.obolibrary.org/obo/HP_0004625		
UBERON:0004554	biolink:AnatomicalEntity	hindlimb digital artery	A digital artery that is part of a hindlimb [Automatically generated definition].	MA:0001964|EMAPA:37214|FMA:69713	hp.json	digital artery of foot|hindlimb digital arteries	http://purl.obolibrary.org/obo/UBERON_0004554		
UBERON:0004552	biolink:AnatomicalEntity	digital artery	An artery that is part of a digit [Automatically generated definition].	EMAPA:37076|MA:0001941	hp.json		http://purl.obolibrary.org/obo/UBERON_0004552		
UBERON:0004553	biolink:AnatomicalEntity	forelimb digital artery	A digital artery that is part of a forelimb [Automatically generated definition].	EMAPA:37210|MA:0001953	hp.json	forelimb digital arteries|digital artery of manus|wing digital artery	http://purl.obolibrary.org/obo/UBERON_0004553		
HP:0100248	biolink:PhenotypicFeature	Hemiballismus	Hemiballismus is a rare movement disorder that is caused primarily by damage to various areas in the basal ganglia. Hemiballismus is usually characterized by involuntary flinging motions of the extremities. The movements are often violent and have wide amplitudes of motion. They are continuous and random and can involve proximal and/or distal muscles on one side of the body, while some cases even include the facial muscles. The more a patient is active, the more the movements increase. With relaxation comes a decrease in movements.	SNOMEDCT_US:66637005|UMLS:C0221169|MSH:D020820	hp.json	Ballismus	http://purl.obolibrary.org/obo/HP_0100248		
HP:0100249	biolink:PhenotypicFeature	Calcification of muscles	Deposition of calcium salts in muscle tissue.	SNOMEDCT_US:446993003|UMLS:C2960760	hp.json	Skeletal muscle calcinosis	http://purl.obolibrary.org/obo/HP_0100249		
HP:0100246	biolink:PhenotypicFeature	Osteoma	Osteomas are bony growths found most commonly on the skull and mandible; however, they may occur in any bone of the body. Osteomas do not usually cause clinical problems and do not become malignant.	MSH:D010016|UMLS:C0029440|SNOMEDCT_US:302858007|SNOMEDCT_US:83612000|NCIT:C3296	hp.json		http://purl.obolibrary.org/obo/HP_0100246		
HP:0100247	biolink:PhenotypicFeature	Recurrent singultus	A contraction of the diaphragm that repeats several times per minute. In humans, the abrupt rush of air into the lungs causes the epiglottis to close, creating a hic sound. Also known as synchronous diaphragmatic flutter (SDF), or singultus, from the Latin singult, the act of catching one's breath while sobbing. The hiccup is an involuntary action involving a reflex arc.	MSH:D006606|SNOMEDCT_US:65958008|UMLS:C0744897|UMLS:C0019521	hp.json	Hiccups|Recurrent hiccough|Recurrent synchronous diaphragmatic flutter|Hiccup|Recurrent hiccup	http://purl.obolibrary.org/obo/HP_0100247		
GO:0030017	biolink:CellularComponent	sarcomere	The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.	Wikipedia:Sarcomere	hp.json		http://purl.obolibrary.org/obo/GO_0030017		
HP:0100244	biolink:PhenotypicFeature	Fibrosarcoma	A fibroblastic sarcoma is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells.	SNOMEDCT_US:443250000|NCIT:C6605|MSH:D005354|SNOMEDCT_US:53654007|UMLS:C0016057	hp.json		http://purl.obolibrary.org/obo/HP_0100244		
HP:0100245	biolink:PhenotypicFeature	Desmoid tumors	Benign, slow-growing tumors without any metastatic potential. Despite their benign nature, they can damage nearby structures causing organ dysfunction. Histologically they resemble low-grade fibrosarcomas, but they are very locally aggressive and tend to recur even after complete resection. There is a tendency for recurrence in the setting of prior surgery and the most common localisation of these tumors is intraabdominal from smooth muscle cells of the instestine.	SNOMEDCT_US:400055004|UMLS:C0079218|SNOMEDCT_US:399994005|SNOMEDCT_US:47284001|MSH:D018222|NCIT:C3042	hp.json	Desmoid tumours	http://purl.obolibrary.org/obo/HP_0100245		
HP:0100242	biolink:PhenotypicFeature	Sarcoma	A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.	SNOMEDCT_US:269469005|SNOMEDCT_US:424952003|UMLS:C1261473|SNOMEDCT_US:424413001|SNOMEDCT_US:2424003|MSH:D012509|NCIT:C9118	hp.json	Malignant connective tissue tumor|Malignant connective tissue tumour|Cancer of connective tissue	http://purl.obolibrary.org/obo/HP_0100242		
HP:0100243	biolink:PhenotypicFeature	Leiomyosarcoma	A smooth muscle connective tissue tumor, which is rare type of cancer that is a malignant neoplasm of smooth muscle. When such a neoplasm is benign, it is called a leiomyoma.	SNOMEDCT_US:443719001|UMLS:C0023269|SNOMEDCT_US:51549004|NCIT:C3158|MSH:D007890	hp.json		http://purl.obolibrary.org/obo/HP_0100243		
GO:0030016	biolink:CellularComponent	myofibril	The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.	Wikipedia:Myofibril	hp.json		http://purl.obolibrary.org/obo/GO_0030016		
HP:0100240	biolink:PhenotypicFeature	Synostosis of joints	The abnormal fusion of neighboring bones across a joint.	UMLS:C4022183	hp.json	Fusion of joints|Bony ankylosis	http://purl.obolibrary.org/obo/HP_0100240		
HP:0100241	biolink:PhenotypicFeature	Ectopic respiratory mucosa	Ectopic respiratory epithelium presenting as a superficial lesion in the skin usually localised unilateral in the skin of the forearm and associated with ipsilateral hand malformations.	UMLS:C4022182	hp.json		http://purl.obolibrary.org/obo/HP_0100241		
PATO:0002422	biolink:NamedThing	acinar	Pertaining to the individual parts making up an aggregate fruit like a many-lobed "berry," such as a raspberry.		hp.json		http://purl.obolibrary.org/obo/PATO_0002422		value_slim|mpath_slim
GO:0030010	biolink:BiologicalProcess	establishment of cell polarity	The specification and formation of anisotropic intracellular organization or cell growth patterns.		hp.json	cell polarization|bud site selection/establishment of cell polarity	http://purl.obolibrary.org/obo/GO_0030010		
GO:0019693	biolink:BiologicalProcess	ribose phosphate metabolic process	The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar.		hp.json	ribose phosphate metabolism	http://purl.obolibrary.org/obo/GO_0019693		
HP:0100259	biolink:PhenotypicFeature	Postaxial polydactyly	A form of polydactyly in which the extra digit or digits are localized on the side of the fifth finger or fifth toe.	UMLS:C0220697|MSH:C562429	hp.json	Postaxial hexadactyly|Polydactyly, postaxial	http://purl.obolibrary.org/obo/HP_0100259		
HP:0100257	biolink:PhenotypicFeature	Ectrodactyly	A condition in which middle parts of the hands and/or feet (digits and meta-carpals and -tarsals) are missing giving a cleft appearance. The severity is very variable ranging from slightly hypoplastic 3rd toe/fingers over absent 2nd or 3rd toes/fingers as far as oligo- or monodactyl hands and/or feet.	SNOMEDCT_US:81208006|UMLS:C0265554|MSH:C574275|SNOMEDCT_US:13624003	hp.json	Cleft hand|Lobster claw hand	http://purl.obolibrary.org/obo/HP_0100257		hposlim_core
HP:0100258	biolink:PhenotypicFeature	Preaxial polydactyly	A form of polydactyly in which the extra digit or digits are localized on the side of the thumb or great toe.	SNOMEDCT_US:205135003|UMLS:C0345354	hp.json	Polydactyly, preaxial	http://purl.obolibrary.org/obo/HP_0100258		
HP:0100255	biolink:PhenotypicFeature	Metaphyseal dysplasia	The presence of dysplastic regions in metaphyseal regions.	UMLS:C0265294|SNOMEDCT_US:27837003|MSH:C536252	hp.json		http://purl.obolibrary.org/obo/HP_0100255		
HP:0100256	biolink:PhenotypicFeature	Senile plaques	Senile plaques are extracellular deposits of amyloid in the gray matter of the brain.	MSH:D058225|SNOMEDCT_US:38551001|UMLS:C0333463	hp.json	Neuritic plaques|Senile druse|Braindruse	http://purl.obolibrary.org/obo/HP_0100256		
GO:0030004	biolink:BiologicalProcess	cellular monovalent inorganic cation homeostasis	Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0030004		
HP:0100253	biolink:PhenotypicFeature	Abnormality of the medullary cavity of the long bones	An abnormality of the medullary cavity (medulla, innermost part), which is the central cavity of bone shafts where red bone marrow and/or yellow bone marrow (adipose tissue) is stored.	UMLS:C4021027	hp.json	Abnormality of the marrow cavity of the long bones	http://purl.obolibrary.org/obo/HP_0100253		
HP:0100254	biolink:PhenotypicFeature	Stenosis of the medullary cavity of the long bones		UMLS:C4022179	hp.json		http://purl.obolibrary.org/obo/HP_0100254		
HP:0100251	biolink:PhenotypicFeature	Multiple central nervous system lipomas	The presence of mulitple lipomas located in the central nervous system.	UMLS:C4022180|NCIT:C3192	hp.json	Lipomas of the central nervous system	http://purl.obolibrary.org/obo/HP_0100251		
HP:0100252	biolink:PhenotypicFeature	Diaphyseal dysplasia		SNOMEDCT_US:34643004|UMLS:C0011989|MSH:D003966|SNOMEDCT_US:318761000119105	hp.json		http://purl.obolibrary.org/obo/HP_0100252		
HP:0100250	biolink:PhenotypicFeature	Meningeal calcification	Calcium deposition affecting the Meninges.	UMLS:C4022181	hp.json		http://purl.obolibrary.org/obo/HP_0100250		
GO:0017046	biolink:MolecularActivity	peptide hormone binding	Binding to a peptide with hormonal activity in animals.		hp.json	polypeptide hormone binding	http://purl.obolibrary.org/obo/GO_0017046		
GO:0030002	biolink:BiologicalProcess	cellular anion homeostasis	Any process involved in the maintenance of an internal steady state of anions at the level of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0030002		
GO:0030003	biolink:BiologicalProcess	cellular cation homeostasis	Any process involved in the maintenance of an internal steady state of cations at the level of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0030003		
GO:0030001	biolink:BiologicalProcess	metal ion transport	The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	heavy metal ion transport|divalent metal ion transport|divalent metal ion export|metal ion export	http://purl.obolibrary.org/obo/GO_0030001		
HP:0100268	biolink:PhenotypicFeature	Upper lip pit	Depression located on the vermilion of the upper lip, usually paramedian.	UMLS:C4022176	hp.json		http://purl.obolibrary.org/obo/HP_0100268		
HP:0100269	biolink:PhenotypicFeature	Paramedian lip pit	Depression located paramedially on the vermilion of a lip.	UMLS:C4022175	hp.json	Paramedian labial pits	http://purl.obolibrary.org/obo/HP_0100269		
HP:0100266	biolink:PhenotypicFeature	Synostosis of carpals/tarsals	The carpus consists of the scaphoid, lunate, triquetal, pisiform, captitate, hamate, trapezoid, and trapezium bones. The tarsus consists of the talus, calcaneus, cuboid, cuneiform, and navicular bones. This term applies if there is any fusion among the bones of the carpus or tarsus.	UMLS:C4021025	hp.json	Wrist bone/ankle bone fusions|Fusion of carpal and tarsal bones|Carpal and tarsal fusions|Coalescence of carpal and tarsal bones	http://purl.obolibrary.org/obo/HP_0100266		
HP:0100267	biolink:PhenotypicFeature	Lip pit	A depression located on a lip.	UMLS:C0341059	hp.json		http://purl.obolibrary.org/obo/HP_0100267		hposlim_core
HP:0100264	biolink:PhenotypicFeature	Proximal symphalangism		UMLS:C1861385|MSH:C536223	hp.json	Cushing's symphalangism	http://purl.obolibrary.org/obo/HP_0100264		
HP:0100265	biolink:PhenotypicFeature	Synostosis of metacarpals/metatarsals		UMLS:C4022177	hp.json	Fusion of long bones of hand/long bones of foot	http://purl.obolibrary.org/obo/HP_0100265		
HP:0100262	biolink:PhenotypicFeature	Synostosis involving digits		UMLS:C4022178	hp.json	Fusion involving digits	http://purl.obolibrary.org/obo/HP_0100262		
HP:0100263	biolink:PhenotypicFeature	Distal symphalangism		UMLS:C1861401|MSH:C566099	hp.json	Symphalangism, distal	http://purl.obolibrary.org/obo/HP_0100263		
HP:0100260	biolink:PhenotypicFeature	Mesoaxial polydactyly	The presence of a supernumerary finger or toe (not a thumb or hallux) involving the third or fourth metacarpal/tarsal with associated osseous syndactyly.	UMLS:C4020689|UMLS:C1848595	hp.json	Intercalary polydactyly|Insertional polydactyly|Central polydactyly	http://purl.obolibrary.org/obo/HP_0100260		
HP:0100261	biolink:PhenotypicFeature	Abnormal tendon morphology	An abnormality of the structure or form of the tendons, also often called sinews.	UMLS:C4021026	hp.json	Abnormality of the sinew|Abnormal shape of tendon	http://purl.obolibrary.org/obo/HP_0100261		
PATO:0002444	biolink:NamedThing	mineralized			hp.json		http://purl.obolibrary.org/obo/PATO_0002444		
HP:0100279	biolink:PhenotypicFeature	Ulcerative colitis	A chronic inflammatory bowel disease that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset and intermittent periods of exacerbated symptoms contrasting with periods that are relatively symptom-free. In contrast to Crohn's disease this special form of colitis begins in the distal parts of the rectum, spreads continually upwards and affects only mucose and submucose tissue of the colon.	UMLS:C0009324|MSH:D003093|SNOMEDCT_US:64766004	hp.json	Colitis ulcerosa	http://purl.obolibrary.org/obo/HP_0100279		
HP:0100277	biolink:PhenotypicFeature	Periauricular skin pits	Benign congenital lesions of the periauricular soft tissue consisting of a blind-ending narrow tube or pit.	UMLS:C4022171	hp.json	Periauricular pits|Periauricular earpits|Pits around the ear|Periauricular sinus|Periauricular fistulas	http://purl.obolibrary.org/obo/HP_0100277		
HP:0100275	biolink:PhenotypicFeature	Diffuse cerebellar atrophy	Diffuse unlocalised atrophy affecting the cerebellum.	UMLS:C1854699	hp.json		http://purl.obolibrary.org/obo/HP_0100275		
HP:0100276	biolink:PhenotypicFeature	Skin pit	A small, skin-lined tract that leads from the surface to deep within the tissues.	UMLS:C4022172|UMLS:C4020712	hp.json	Skin pit|Skin pits	http://purl.obolibrary.org/obo/HP_0100276		
HP:0100273	biolink:PhenotypicFeature	Neoplasm of the colon		MSH:D003110|NCIT:C3262|SNOMEDCT_US:126838000|UMLS:C0009375	hp.json	Colon tumor|Colon tumour	http://purl.obolibrary.org/obo/HP_0100273		
RO:0002022	biolink:NamedThing	directly regulated by			hp.json		http://purl.obolibrary.org/obo/RO_0002022		
HP:0100274	biolink:PhenotypicFeature	Gustatory lacrimation	Gustatory lacrimation results from an aberrant innervation of fibres from the seventh cranial nerve to the pterygopalatine ganglion which are destined originally for the submandibular ganglion. This aberrant innervation leads to uncontrollable tearing while eating or in anticipation of a meal.	UMLS:C1862052	hp.json		http://purl.obolibrary.org/obo/HP_0100274		
RO:0002023	biolink:NamedThing	directly negatively regulated by	Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.		hp.json		http://purl.obolibrary.org/obo/RO_0002023		
HP:0100271	biolink:PhenotypicFeature	Hyponasal speech	Hyponasal speech is when there is an abnormally reduced nasal airflow during speech often in a setting of nasal obstruction or congestion.	UMLS:C4022173	hp.json		http://purl.obolibrary.org/obo/HP_0100271		
RO:0002024	biolink:NamedThing	directly positively regulated by	Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.		hp.json		http://purl.obolibrary.org/obo/RO_0002024		
RO:0002025	biolink:NamedThing	has effector activity	A 'has effector activity' B if A and B are GO molecular functions (GO_0003674),  A 'has component activity' B and B is the effector (output function) of B.  Each compound function has only one effector activity.		hp.json		http://purl.obolibrary.org/obo/RO_0002025		
HP:0100272	biolink:PhenotypicFeature	Branchial sinus	A congenital branchial sinus is a remnant of the embryonic branchial arches and their intervening clefts and pouches that has failed to regress completely. Sinuses typically have their external orifice inferior to the ramus of the mandible. They may traverse the parotid gland, and run in close vicinity to the facial nerve in the external auditory canal.	UMLS:C0266624|SNOMEDCT_US:253259008	hp.json	Branchial cleft sinus	http://purl.obolibrary.org/obo/HP_0100272		
HP:0100270	biolink:PhenotypicFeature	Abnormality of dorsoventral patterning of the limbs	An abnormality resulting from a defect or disruption of dorsoventral patterning that normally happens during early development of the limbs. A disruption of the normal development of the dorsoventral axis may lead to a variable spectrum of different phenotypic abnormalities that may affect the nails and or palmar and dorsal side of the hands and/or feet, ultimately changing the normal dorsoventral appearance of the affected limbs.	UMLS:C4022174	hp.json		http://purl.obolibrary.org/obo/HP_0100270		
RO:0002021	biolink:NamedThing	occurs across	A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization.		hp.json		http://purl.obolibrary.org/obo/RO_0002021		
RO:0002015	biolink:NamedThing	has positive regulatory component activity	A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.		hp.json		http://purl.obolibrary.org/obo/RO_0002015		
RO:0002017	biolink:NamedThing	has component activity			hp.json		http://purl.obolibrary.org/obo/RO_0002017		
RO:0002018	biolink:NamedThing	has component process	w 'has process component' p if p and w are processes,  w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.		hp.json		http://purl.obolibrary.org/obo/RO_0002018		
GO:0032642	biolink:BiologicalProcess	regulation of chemokine production	Any process that modulates the frequency, rate, or extent of chemokine production.		hp.json	regulation of chemokine secretion|regulation of chemokine biosynthetic process	http://purl.obolibrary.org/obo/GO_0032642		
HP:0100288	biolink:PhenotypicFeature	EMG: myokymic discharges	The presence of spontaneous bursts of rapidly firing potentials that recur at regular intervals of 2-10 per second and are unaffected by voluntary effort. This is an electromyographic (EMG) finding.	UMLS:C4022166	hp.json		http://purl.obolibrary.org/obo/HP_0100288		
HP:0100289	biolink:PhenotypicFeature	Abnormality of pattern reversal visual evoked potentials		UMLS:C4022165	hp.json	Abnormality of pattern reversal VEP	http://purl.obolibrary.org/obo/HP_0100289		
HP:0100287	biolink:PhenotypicFeature	EMG: slow motor conduction	The presence of reduced conduction velocity of motor nerves on electromyography.	UMLS:C4022167	hp.json		http://purl.obolibrary.org/obo/HP_0100287		
HP:0100284	biolink:PhenotypicFeature	EMG: myotonic discharges	High frequency discharges in electromyography (EMG) that vary in amplitude and frequency, waxing and waning continuously with firing frequencies ranging from 150/second down to 20/second and producing a sound that has been referred to as a dive bomber sound.	UMLS:C4022169	hp.json		http://purl.obolibrary.org/obo/HP_0100284		
HP:0100285	biolink:PhenotypicFeature	EMG: impaired neuromuscular transmission	An electromyographic finding associated with erratic or absent neuromuscular transmission with erratic, moment-to-moment changes in the shape of the motor unit potential (MUP).	UMLS:C4022168	hp.json		http://purl.obolibrary.org/obo/HP_0100285		
RO:0002013	biolink:NamedThing	has regulatory component activity	A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.	RO:0002013	hp.json		http://purl.obolibrary.org/obo/RO_0002013		
HP:0100282	biolink:PhenotypicFeature	Acute colitis	An acute and self-limited inflammatory disease of the large intestine (colon, cecum and rectum).	UMLS:C2118460	hp.json		http://purl.obolibrary.org/obo/HP_0100282		
RO:0002014	biolink:NamedThing	has negative regulatory component activity	A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole.  More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.	RO:0002014	hp.json		http://purl.obolibrary.org/obo/RO_0002014		
HP:0100283	biolink:PhenotypicFeature	EMG: continuous motor unit activity at rest	Continuous electromyographic activity of motor units at rest, i.e., without voluntary movement of the muscles.	UMLS:C4022170	hp.json		http://purl.obolibrary.org/obo/HP_0100283		
HP:0100280	biolink:PhenotypicFeature	Crohn's disease	A chronic granulomatous inflammatory disease of the intestines that may affect any part of the gastrointestinal tract from mouth to anus, causing a wide variety of symptoms. It primarily causes abdominal pain, diarrhea which may be bloody, vomiting, or weight loss, but may also cause complications outside of the gastrointestinal tract such as skin rashes, arthritis, inflammation of the eye, tiredness, and lack of concentration. Crohn's disease is thought to be an autoimmune disease, in which the body's immune system attacks the gastrointestinal tract, causing inflammation.	MSH:D003424|UMLS:C0010346|SNOMEDCT_US:34000006	hp.json	Morbus Crohn|Granulomatous enteritis and colitis	http://purl.obolibrary.org/obo/HP_0100280		
HP:0100281	biolink:PhenotypicFeature	Chronic colitis	A chronic inflammatory disease of the large intestine (colon, cecum and rectum).	UMLS:C0267375|SNOMEDCT_US:54597004	hp.json		http://purl.obolibrary.org/obo/HP_0100281		
GO:0042044	biolink:NamedThing	fluid transport			hp.json		http://purl.obolibrary.org/obo/GO_0042044		
CHEBI:57485	biolink:ChemicalSubstance	carnosine zwitterion	Zwitterionic form of carnosine.	Gmelin:397437|MetaCyc:CARNOSINE	hp.json	(2S)-2-[(3-azaniumylpropanoyl)amino]-3-(1H-imidazol-4-yl)propanoate|N(alpha)-(beta-alaniniumyl)-L-histidinate|carnosine	http://purl.obolibrary.org/obo/CHEBI_57485		3_STAR
RO:0002005	biolink:NamedThing	innervated_by		RO:0002005	hp.json		http://purl.obolibrary.org/obo/RO_0002005		
RO:0002007	biolink:NamedThing	bounding layer of	X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y . exists Z :surface . X has_boundary Z . Z boundary_of Y  has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000	RO:0002007	hp.json		http://purl.obolibrary.org/obo/RO_0002007		ro-eco
UBERON:0006801	biolink:AnatomicalEntity	proximal head of humerus	Hemispherical structure on proximal epiphysis of humerus that articulates with glenoid cavity[WP,modified].	EMAPA:25050|UMLS:C0223683|FMA:13304|galen:HeadOfHumerus|AAO:0000835|NCIT:C32720	hp.json	humeral head|head of humerus|caput humeri	http://purl.obolibrary.org/obo/UBERON_0006801		pheno_slim
UBERON:0006800	biolink:AnatomicalEntity	anatomical line	Non-material anatomical entity of one dimension, which forms a boundary of an anatomical surface or is a modulation of an anatomical surface.	HAO:0000008|TAO:0001837|ZFA:0001689|FMA:9657|EHDAA2:0003008|XAO:0004003|TGMA:0001828|BILA:0000008|AEO:0000008|AAO:0010267|CARO:0000008	hp.json		http://purl.obolibrary.org/obo/UBERON_0006800		upper_level
HP:0100299	biolink:PhenotypicFeature	Muscle fiber inclusion bodies		UMLS:C4022159	hp.json	Muscle fibre inclusion bodies	http://purl.obolibrary.org/obo/HP_0100299		
HP:0100297	biolink:PhenotypicFeature	Increased endomysial connective tissue	An increased volume of the endomysium, which is a connective tissue sheath that surrounds each muscule fiber. Together, bundles of muscle fibers form a fasciculus, surrounded by another layer of connective tissue called the perimysium.	UMLS:C4022161	hp.json	Endomysial fibrosis	http://purl.obolibrary.org/obo/HP_0100297		
HP:0100298	biolink:PhenotypicFeature	Motheaten muscle fibers		UMLS:C4022160	hp.json	Motheaten muscle fibres	http://purl.obolibrary.org/obo/HP_0100298		
RO:0002000	biolink:NamedThing	2D boundary of	a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity		hp.json		http://purl.obolibrary.org/obo/RO_0002000		
HP:0100295	biolink:PhenotypicFeature	Muscle fiber atrophy		UMLS:C0333751|SNOMEDCT_US:67867005	hp.json	Muscle fibre degeneration|Muscle fiber degeneration|Muscle fibre atrophy	http://purl.obolibrary.org/obo/HP_0100295		
HP:0100296	biolink:PhenotypicFeature	Perifascicular muscle fiber atrophy		UMLS:C0333757|SNOMEDCT_US:87196003	hp.json	Perifascicular muscle fibre atrophy	http://purl.obolibrary.org/obo/HP_0100296		
RO:0002002	biolink:NamedThing	has 2D boundary	a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity	RO:0002002	hp.json		http://purl.obolibrary.org/obo/RO_0002002		
HP:0100293	biolink:PhenotypicFeature	Hypertrophied muscle fibers	The presence of an increased amount of muscle fibers with an increased diameter. This feature can be ascertained by microscopic examination of a muscle biopsy sample. Together with fiber size variation and atrophied muscle fibers, and hypertrophied muscle fibers are commonly found in myopathies.	SNOMEDCT_US:42091004|UMLS:C0333759	hp.json	Muscle fiber hypertrophy|Muscle fibre hypertrophy	http://purl.obolibrary.org/obo/HP_0100293		
GO:0042053	biolink:BiologicalProcess	regulation of dopamine metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine.		hp.json	regulation of dopamine metabolism	http://purl.obolibrary.org/obo/GO_0042053		
HP:0100291	biolink:PhenotypicFeature	Abnormality of central somatosensory evoked potentials		UMLS:C4022163	hp.json		http://purl.obolibrary.org/obo/HP_0100291		
HP:0100292	biolink:PhenotypicFeature	Amyloidosis of peripheral nerves	The presence of amyloid deposition in the nerves of the peripheral nervous system.	UMLS:C4022162	hp.json		http://purl.obolibrary.org/obo/HP_0100292		
HP:0100290	biolink:PhenotypicFeature	Abnormality of peripheral somatosensory evoked potentials		UMLS:C4022164	hp.json		http://purl.obolibrary.org/obo/HP_0100290		
GO:0042060	biolink:BiologicalProcess	wound healing	The series of events that restore integrity to a damaged tissue, following an injury.	Wikipedia:Wound_healing	hp.json		http://purl.obolibrary.org/obo/GO_0042060		goslim_generic
PATO:0002403	biolink:NamedThing	generalized	Affecting all regions without specificity of distribution.		hp.json	generalised	http://purl.obolibrary.org/obo/PATO_0002403		value_slim|mpath_slim|hpo_slim
OBO:nbo#by_means	biolink:NamedThing	by_means			hp.json		http://purl.obolibrary.org/obo/nbo#by_means		
GO:0042069	biolink:BiologicalProcess	regulation of catecholamine metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.		hp.json	regulation of catecholamine metabolism	http://purl.obolibrary.org/obo/GO_0042069		
GO:0042063	biolink:BiologicalProcess	gliogenesis	The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.		hp.json	glial cell generation	http://purl.obolibrary.org/obo/GO_0042063		
GO:0042065	biolink:BiologicalProcess	glial cell growth	Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0042065		
CHEBI:33497	biolink:ChemicalSubstance	transition element molecular entity	A molecular entity containing one or more atoms of a transition element.		hp.json	transition metal molecular entity|transition element molecular entities	http://purl.obolibrary.org/obo/CHEBI_33497		3_STAR
GO:0019637	biolink:BiologicalProcess	organophosphate metabolic process	The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.		hp.json	organophosphate metabolism	http://purl.obolibrary.org/obo/GO_0019637		
PATO:0002400	biolink:NamedThing	fusiform	Having a spindle-like shape that is wide in the middle and tapers at both ends.		hp.json		http://purl.obolibrary.org/obo/PATO_0002400		value_slim|mpath_slim
GO:0042073	biolink:BiologicalProcess	intraciliary transport	The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.	Wikipedia:Intraflagellar_transport	hp.json	intraflagellar transport involved in cilium organization|intraflagellar transport|IFT|intraflagellar transport involved in microtubule-based flagellum organisation	http://purl.obolibrary.org/obo/GO_0042073		
GO:0032602	biolink:BiologicalProcess	chemokine production	The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.		hp.json	chemokine metabolic process|chemokine anabolism|chemokine synthesis|chemokine biosynthetic process|chemokine formation|chemokine secretion|chemokine biosynthesis	http://purl.obolibrary.org/obo/GO_0032602		gocheck_do_not_annotate
GO:0042078	biolink:BiologicalProcess	germ-line stem cell division	The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.		hp.json	germ-line stem cell renewal	http://purl.obolibrary.org/obo/GO_0042078		
PATO:0002418	biolink:NamedThing	acidophilic	An affinity inhering in an anatomical structure by virtue of the bearer exhibiting a molecular interaction for acidic dyes under specific pH conditions.		hp.json		http://purl.obolibrary.org/obo/PATO_0002418		value_slim|mpath_slim
GO:0042074	biolink:BiologicalProcess	cell migration involved in gastrulation	The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).		hp.json		http://purl.obolibrary.org/obo/GO_0042074		
NBO:0000455	biolink:NamedThing	attention behavior	"The sustained focus of cognitive resources on information while filtering or ignoring extraneous information.  Intended to encompass only attention to perceptual stimuli. " [wikipedia:Attention]		hp.json		http://purl.obolibrary.org/obo/NBO_0000455		
HP:0004399	biolink:PhenotypicFeature	Congenital pyloric atresia	Congenital atresia of the pylorus.	UMLS:C4025327	hp.json		http://purl.obolibrary.org/obo/HP_0004399		hposlim_core
HP:0004394	biolink:PhenotypicFeature	Multiple gastric polyps		SNOMEDCT_US:87252009|MSH:C562464|SNOMEDCT_US:78809005|UMLS:C0236048	hp.json		http://purl.obolibrary.org/obo/HP_0004394		
HP:0004392	biolink:PhenotypicFeature	Prune belly	A kind of congenital defect of the anterior abdominal wall in which the intestines are evident through the thin, lax, and protruding abdominal wall in affected infants.	UMLS:C0033770|SNOMEDCT_US:5187006|MSH:D011535	hp.json	Prune belly	http://purl.obolibrary.org/obo/HP_0004392		
GO:0030099	biolink:BiologicalProcess	myeloid cell differentiation	The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.		hp.json		http://purl.obolibrary.org/obo/GO_0030099		
GO:0030097	biolink:BiologicalProcess	hemopoiesis	The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.	Wikipedia:Haematopoiesis	hp.json	blood cell formation|hematopoiesis|blood cell biosynthesis|haemopoiesis	http://purl.obolibrary.org/obo/GO_0030097		
HP:0004398	biolink:PhenotypicFeature	Peptic ulcer	The term peptic ulcer refers to acid peptic injury of the digestive tract, resulting in mucosal break reaching the submucosa. Peptic ulcers are usually located in the stomach or proximal duodenum, but they can also be found in the oesophagus or Meckel's diverticulum. Infection with Helicobacter pylori and the use of non steroidal antiinflammatory drugs (NSAIDs) or aspirin are the main risk factors of both gastric and duodenal peptic ulcers.	UMLS:C0030920|SNOMEDCT_US:13200003|MSH:D010437	hp.json	Sore in the lining of gastrointestinal tract	http://purl.obolibrary.org/obo/HP_0004398		
GO:0030098	biolink:BiologicalProcess	lymphocyte differentiation	The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.		hp.json	lymphocytic blood cell differentiation|lymphocyte cell differentiation|lymphocyte development	http://purl.obolibrary.org/obo/GO_0030098		
HP:0004397	biolink:PhenotypicFeature	Ectopic anus	Abnormal displacement or malposition of the anus.	SNOMEDCT_US:5153001|UMLS:C0266231	hp.json	Abnormal anus position|Anus malposition	http://purl.obolibrary.org/obo/HP_0004397		hposlim_core
HP:0004396	biolink:PhenotypicFeature	Poor appetite	A reduced desire to eat.	UMLS:C0232462|SNOMEDCT_US:64379006	hp.json	Poor appetite|Decreased appetite|No appetite|Loss of appetite	http://purl.obolibrary.org/obo/HP_0004396		
HP:0004395	biolink:PhenotypicFeature	Malnutrition	A deficiency in the intake of energy and nutrients.	SNOMEDCT_US:47563007|MSH:D044342|SNOMEDCT_US:248325000|SNOMEDCT_US:2492009|SNOMEDCT_US:70241007|SNOMEDCT_US:65404009|UMLS:C0162429	hp.json	Malnutrition	http://purl.obolibrary.org/obo/HP_0004395		
NBO:0000469	biolink:NamedThing	stress related behavior	"Behavior related to how the body reacts to a stressor ( a stimulus that causes stress), real or imagined." [wikipedia:Stress_(biological)]		hp.json		http://purl.obolibrary.org/obo/NBO_0000469		
NBO:0000474	biolink:NamedThing	circadian behavior phenotype			hp.json	pathological circadian behaviour	http://purl.obolibrary.org/obo/NBO_0000474		
NBO:0000473	biolink:NamedThing	rhythmic behavior phenotype			hp.json		http://purl.obolibrary.org/obo/NBO_0000473		
GO:0030072	biolink:BiologicalProcess	peptide hormone secretion	The regulated release of a peptide hormone from a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0030072		
HP:0004379	biolink:PhenotypicFeature	Abnormality of alkaline phosphatase level	An abnormality of alkaline phosphatase level.	UMLS:C4025328|UMLS:C4020829	hp.json	Abnormality of ALP level|Alkaline phosphatase abnormal|Abnormality of alkaline phosphatase activity	http://purl.obolibrary.org/obo/HP_0004379		
HP:0004378	biolink:PhenotypicFeature	Abnormality of the anus	Abnormality of the anal canal.	UMLS:C4025329	hp.json	Abnormality of the anus	http://purl.obolibrary.org/obo/HP_0004378		
HP:0004377	biolink:PhenotypicFeature	Hematological neoplasm	Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue).	SNOMEDCT_US:129154003|SNOMEDCT_US:269475001|UMLS:C0376545|MSH:D019337	hp.json	Blood tumor|Blood tumour|Haematological neoplasm	http://purl.obolibrary.org/obo/HP_0004377		
HP:0004372	biolink:PhenotypicFeature	Reduced consciousness/confusion		UMLS:C0234428|SNOMEDCT_US:3006004	hp.json	Disturbances of consciousness|Lowered consciousness|Reduced consciousness/confusion	http://purl.obolibrary.org/obo/HP_0004372		
HP:0004371	biolink:PhenotypicFeature	Abnormality of glycosaminoglycan metabolism	Abnormality of glycosaminoglycan metabolism.	UMLS:C4025330	hp.json		http://purl.obolibrary.org/obo/HP_0004371		
HP:0004370	biolink:PhenotypicFeature	Abnormality of temperature regulation	An abnormality of temperature homeostasis.	MSH:D001832|UMLS:C0005904|UMLS:C1832160	hp.json	Abnormality of temperature regulation|Poor temperature regulation|Body temperature changes	http://purl.obolibrary.org/obo/HP_0004370		
HP:0004376	biolink:PhenotypicFeature	Neuroblastic tumor	A family of tumours arising in the embryonal remnants of the sympathetic nervous system, which includes neuroblastoma, ganglioneuroblastoma, and ganglioneuroma.	UMLS:C1334953	hp.json	Neuroblastic tumour	http://purl.obolibrary.org/obo/HP_0004376		
HP:0004375	biolink:PhenotypicFeature	Neoplasm of the nervous system	A tumor (abnormal growth of tissue) of the nervous system.	NCIT:C3262|SNOMEDCT_US:126950007|UMLS:C0027766|MSH:D009423	hp.json	Tumour of the nervous system|Tumor of the nervous system|Neoplasia of the nervous system|Nervous system cancer	http://purl.obolibrary.org/obo/HP_0004375		
HP:0004374	biolink:PhenotypicFeature	Hemiplegia/hemiparesis	Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a severe or complete loss of strength, whereas hemiparesis refers to a relatively mild loss of strength.	UMLS:C0375206	hp.json	Paralysis or weakness of one side of body	http://purl.obolibrary.org/obo/HP_0004374		
GO:0030073	biolink:NamedThing	insulin secretion			hp.json		http://purl.obolibrary.org/obo/GO_0030073		
HP:0004373	biolink:PhenotypicFeature	Focal dystonia	A type of dystonia that is localized to a specific part of the body.	UMLS:C0743332|SNOMEDCT_US:445006008|MSH:D020821	hp.json		http://purl.obolibrary.org/obo/HP_0004373		
HP:0004390	biolink:PhenotypicFeature	Hamartomatous polyposis	Polyp-like protrusions which are histologically hamartomas. These can occur throughout the gastrointestinal tract. Hamartomatous polyps are composed of the normal cellular elements of the gastrointestinal tract, but have a markedly distorted architecture.	UMLS:C0334092|SNOMEDCT_US:27391005|UMLS:C3277418	hp.json	Gastrointestinal hamartomatous polyps|Gastrointestinal hamartoma|Hamartomatous polyps	http://purl.obolibrary.org/obo/HP_0004390		
NBO:0000446	biolink:NamedThing	visual pursuit	"Selectively track a moving object." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000446		
NBO:0000444	biolink:NamedThing	eye movement			hp.json		http://purl.obolibrary.org/obo/NBO_0000444		
UBERON:0004190	biolink:AnatomicalEntity	renal glomerulus vasculature	The glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the glomerulus.		hp.json	glomerulus vasculature|renal glomerulus vasculature|renal glomerulus vascular network|vasculature of renal glomerulus|vascular network of renal glomerulus	http://purl.obolibrary.org/obo/UBERON_0004190		human_reference_atlas
GO:0140513	biolink:CellularComponent	nuclear protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus.		hp.json	nuclear complex	http://purl.obolibrary.org/obo/GO_0140513		gocheck_do_not_annotate
UBERON:0004198	biolink:AnatomicalEntity	comma-shaped body	The comma-shaped body is the precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron.	ZFA:0005588|EMAPA:27681	hp.json	CSB	http://purl.obolibrary.org/obo/UBERON_0004198		pheno_slim
UBERON:0004199	biolink:AnatomicalEntity	S-shaped body	The S-shaped body is the successor of the comma-shaped body that contributes to the morphogenesis of the nephron.	ZFA:0005589|EMAPA:27756	hp.json	stage II nephron|SSB	http://purl.obolibrary.org/obo/UBERON_0004199		pheno_slim
HP:0004389	biolink:PhenotypicFeature	Intestinal pseudo-obstruction	A functional rather than mechanical obstruction of the intestines, associated with manifestations that resemble those caused by an intestinal obstruction, including distension, abdominal pain, nausea, vomiting, constipation or diarrhea, in an individual in whom a mechanical blockage has been excluded.	UMLS:C0021847|MSH:D007418|SNOMEDCT_US:235825006|SNOMEDCT_US:715201005	hp.json	Intestinal pseudoobstruction	http://purl.obolibrary.org/obo/HP_0004389		
HP:0004388	biolink:PhenotypicFeature	Microcolon	A colon of abnormally small caliber.	SNOMEDCT_US:18389004|MSH:C562563|UMLS:C0266200|UMLS:C3553395	hp.json	Microcolon on contrast enema	http://purl.obolibrary.org/obo/HP_0004388		
HP:0004383	biolink:PhenotypicFeature	Hypoplastic left heart	Underdevelopment of the left side of the heart. May include atresia of the aortic or mitral orifice and hypoplasia of the ascending aorta.	MSH:D018636|UMLS:C0152101|SNOMEDCT_US:62067003	hp.json	Underdeveloped left heart|Left ventricular hypoplasia|Heart left ventricle hypoplasia	http://purl.obolibrary.org/obo/HP_0004383		
HP:0004382	biolink:PhenotypicFeature	Mitral valve calcification	Abnormal calcification of the mitral valve.	SNOMEDCT_US:473372009|UMLS:C0919718	hp.json		http://purl.obolibrary.org/obo/HP_0004382		
HP:0004381	biolink:PhenotypicFeature	Supravalvular aortic stenosis	A pathological narrowing in the region above the aortic valve associated with restricted left ventricular outflow.	SNOMEDCT_US:268185002|UMLS:C0003499|MSH:D021921|Fyler:1430	hp.json		http://purl.obolibrary.org/obo/HP_0004381		
HP:0004380	biolink:PhenotypicFeature	Aortic valve calcification	Deposition of calcium salts in the aortic valve.	MSH:C562942|SNOMEDCT_US:250978003|UMLS:C0428791	hp.json		http://purl.obolibrary.org/obo/HP_0004380		
HP:0004387	biolink:PhenotypicFeature	Enterocolitis	An inflammation of the colon and small intestine. However, most conditions are either categorized as Enteritis (inflammation of the small intestine) or Colitis (inflammation of the large intestine).	MSH:D004760|UMLS:C0014356|SNOMEDCT_US:43752006	hp.json		http://purl.obolibrary.org/obo/HP_0004387		
HP:0004386	biolink:PhenotypicFeature	Gastrointestinal inflammation	Inflammation of the alimentary part of the gastrointestinal system.	UMLS:C1535950	hp.json	GI inflammation|Gastrointestinal inflammation	http://purl.obolibrary.org/obo/HP_0004386		
HP:0004385	biolink:PhenotypicFeature	Protracted diarrhea		UMLS:C0473133|SNOMEDCT_US:236077008	hp.json	Protracted diarrhoea	http://purl.obolibrary.org/obo/HP_0004385		
HP:0004384	biolink:PhenotypicFeature	Type I truncus arteriosus	Truncus arteriosus (single great artery leaving the base of the heart, giving rise to the coronary, pulmonary, and systemic arteries) with a short pulmonary trunk arises from the truncus arteriosus, giving rise to both pulmonary arteries.	Fyler:510|UMLS:C1834934|Fyler:0510	hp.json	Persistent truncus arteriosus type I|Type 1 truncus arteriosus	http://purl.obolibrary.org/obo/HP_0004384		
HP:0100204	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the 5th toe		UMLS:C4022217	hp.json	Cone-shaped end part of the outermost bone of the little toe|Cone-shaped end part of the outermost bone of the pinkie toe|Cone-shaped end part of the outermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100204		
HP:0100205	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the 5th toe		UMLS:C4022216	hp.json	Enlarged end part of the outermost bone of the pinky toe|Enlarged end part of the outermost bone of the little toe|Enlarged end part of the outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100205		
HP:0100202	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the 5th toe		UMLS:C4022219	hp.json	Absent end part of the outermost bone of the pinky toe|Absent end part of the outermost bone of the little toe|Absent end part of the outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100202		
HP:0100203	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the 5th toe		UMLS:C4022218	hp.json	Bracket shaped end part of the outermost bone of the pinkie toe|Bracket shaped end part of the outermost bone of the pinky toe|Bracket shaped end part of the outermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100203		
HP:0100200	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the 4th toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 4th toe.	UMLS:C4022221	hp.json	Speckled calcifications in the end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100200		
HP:0100201	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022220	hp.json	Triangular end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100201		
NBO:0000499	biolink:NamedThing	NREM parasomnia	"A type of parasomnia that occurs during NREM sleep." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000499		
HP:0031980	biolink:PhenotypicFeature	Abnormal urine carboxylic acid level	Any deviation from the normal concentration of a carboxylic acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031980		
HP:0031981	biolink:PhenotypicFeature	Elevated urine glycolate	An increased concentration of glycolate in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031981		
HP:0031982	biolink:PhenotypicFeature	Abnormal putamen morphology	Any structural anomaly of the putamen, a brain nucleus which together with the caudate nucleus and fundus striati makes up the striatum.		hp.json		http://purl.obolibrary.org/obo/HP_0031982		
HP:0031983	biolink:PhenotypicFeature	Abnormal pulmonary thoracic imaging finding	This term groups terms representing abnormal findings derived from chest X-ray investigation of the lung. In general, lung abnormalities can manifest as opacities (areas of increased density) or as regions with decreased density.		hp.json	Abnormal chest radiograph finding (lung)	http://purl.obolibrary.org/obo/HP_0031983		
HP:0031988	biolink:PhenotypicFeature	obsolete Muscle spasm			hp.json		http://purl.obolibrary.org/obo/HP_0031988		
HP:0031989	biolink:PhenotypicFeature	Perioral spasm	A sudden involuntary contraction of the musculature surrounding the mouth.		hp.json		http://purl.obolibrary.org/obo/HP_0031989		
HP:0031984	biolink:PhenotypicFeature	Esophageal food impaction	A piece of food that has gotten stuck in the esophagus and prevents further swallowing.		hp.json		http://purl.obolibrary.org/obo/HP_0031984		
HP:0031985	biolink:PhenotypicFeature	Esophageal exudate	An exudate is a mass of fluid and cells that has seeped out of blood vessels or an organ, usually related to inflammation. In the esophagus, exudates usually present as whitish plagues on the surface of the esophageal mucosa.		hp.json		http://purl.obolibrary.org/obo/HP_0031985		
HP:0031986	biolink:PhenotypicFeature	Polyminimyoclonus	Irregular, small-amplitude myoclonic movements of the hands and/or fingers on keeping outstretched posture (jerky postural tremor). Polyminimyoclonus is stimulus-sensitive and accentuated during voluntary movements. A cortical origin can be demonstrated by back-averaging techniques, and somatosensory evoked potentials (SSEPs) are sometimes giant.		hp.json		http://purl.obolibrary.org/obo/HP_0031986		
HP:0031987	biolink:PhenotypicFeature	Diminished ability to concentrate	Being unable to focus one's attention or mental effort on a particular object or activity.		hp.json	Lack of concentration|Concentration problems|Poor concentration	http://purl.obolibrary.org/obo/HP_0031987		
HP:0100208	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the 5th toe		UMLS:C4022213	hp.json	Increased bone density of end part of the outermost bone of the little toe|Increased bone density of end part of the outermost bone of the pinkie toe|Increased bone density of end part of the outermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100208		
HP:0100209	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the 5th toe		UMLS:C4022212	hp.json		http://purl.obolibrary.org/obo/HP_0100209		
GO:0030054	biolink:CellularComponent	cell junction	A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella.	Wikipedia:Cell_junction	hp.json		http://purl.obolibrary.org/obo/GO_0030054		goslim_agr|goslim_flybase_ribbon|goslim_drosophila
HP:0100206	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the 5th toe		UMLS:C4022215	hp.json	Fragmentation of the end part of the outermost bone of the pinky toe|Fragmentation of the end part of the outermost bone of the little toe|Fragmentation of the end part of the outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100206		
HP:0100207	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the 5th toe		UMLS:C4022214	hp.json	Irregular end part of the outermost bone of the pinky toe|Irregular end part of the outermost bone of the little toe|Irregular end part of the outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100207		
HP:0100215	biolink:PhenotypicFeature	Cone-shaped epiphysis of the middle phalanx of the 5th toe		UMLS:C4022206	hp.json	Cone-shaped end part of the middle bone of the pinky toe|Cone-shaped end part of the middle bone of the little toe|Cone-shaped end part of the middle bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100215		
HP:0100216	biolink:PhenotypicFeature	Enlarged epiphysis of the middle phalanx of the 5th toe		UMLS:C4022205	hp.json	Enlarged end part of the middle bone of the little toe|Enlarged end part of the middle bone of the pinkie toe|Enlarged end part of the middle bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100216		
HP:0100213	biolink:PhenotypicFeature	Absent epiphysis of the middle phalanx of the 5th toe		UMLS:C4022208	hp.json	Absent end part of the middle bone of the pinky toe|Absent end part of the middle bone of the pinkie toe|Absent end part of the middle bone of the little toe	http://purl.obolibrary.org/obo/HP_0100213		
HP:0100214	biolink:PhenotypicFeature	Bracket epiphysis of the middle phalanx of the 5th toe		UMLS:C4022207	hp.json	Bracket shaped end part of the middle bone of the pinkie toe|Bracket shaped end part of the middle bone of the pinky toe|Bracket shaped end part of the middle bone of the little toe	http://purl.obolibrary.org/obo/HP_0100214		
HP:0100211	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the 5th toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 5th toe.	UMLS:C4022210	hp.json	Speckled calcifications in the end part of the outermost bone of the little toe|Speckled calcifications in the end part of the outermost bone of the pinky toe|Speckled calcifications in the end part of the outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100211		
HP:0100212	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the 5th toe		UMLS:C4022209	hp.json	Triangular end part of the outermost bone of the little toe|Triangular end part of the outermost bone of the pinky toe|Triangular end part of the outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100212		
HP:0100210	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the 5th toe		UMLS:C4022211	hp.json	Small end part of the outermost bone of the little toe|Small end part of the outermost bone of the pinky toe|Small end part of the outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100210		
HP:0031991	biolink:PhenotypicFeature	Increased urinary excretion of galactosyl hydroxylysine	An increased concentration of beta-1-galactosyl-O-hydroxylysine (Gal-Hyl) in the urine. This is a biochemical marker of bone resorption.		hp.json		http://purl.obolibrary.org/obo/HP_0031991		
HP:0031992	biolink:PhenotypicFeature	Apical hypertrophic cardiomyopathy	Apical hypertrophic cardiomyopathy (AHCM) is diastolic dysfunction due to abnormal stiffness of the left ventricle during diastole, with resultant impaired ventricular filling. In AHCM thickened apical segments produce a crowded, spade-shaped, small apical cavity.		hp.json		http://purl.obolibrary.org/obo/HP_0031992		
HP:0031993	biolink:PhenotypicFeature	Hoffmann sign	A Hoffman test is performed by flicking the fingernail of the long finger, from dorsal to volar, on each hand while the hand was supported by the examiner's hand. The test was done with the neck in the neutral position and then with the neck maximally forward flexed. Any flexion of the ipsilateral thumb and/or index finger was interpreted as a positive test.		hp.json	Hoffmann's sign	http://purl.obolibrary.org/obo/HP_0031993		
HP:0031994	biolink:PhenotypicFeature	Bronchial breath sound	Bronchial breath sounds contain much higher frequency components than normal breath sounds due to alteration of the low pass filtering function of the alveoli, as occurs in consolidation. It is loud, hollow, and high pitch. Expiratory phase is longer than inspiratory phase with the inspiratory-expiratory ratio (I:E) changing from normal 3:1 to 1:2. There is distinct pause between inspiration and expiration due to absent alveolar phase. It is associated with whispering pectoriloquy.		hp.json		http://purl.obolibrary.org/obo/HP_0031994		
HP:0031990	biolink:PhenotypicFeature	Chvostek sign	A contraction of ipsilateral facial muscles subsequent to percussion over the facial nerve.		hp.json		http://purl.obolibrary.org/obo/HP_0031990		
HP:0031999	biolink:PhenotypicFeature	Expiratory crackles	Crackles that occur during expiration.		hp.json		http://purl.obolibrary.org/obo/HP_0031999		
HP:0031995	biolink:PhenotypicFeature	Squawks	Squawks are short inspiratory wheezes of less than 200 ms duration and are also known as squeaks. Acoustic analysis shows the fundamental frequency varying between 200 and 300 Hz. Squawks usually occur in late inspiration and are often preceded by late inspiratory crackles.		hp.json		http://purl.obolibrary.org/obo/HP_0031995		
HP:0031996	biolink:PhenotypicFeature	Inspiratory crackles	Crackles that are heard during the inspiratory phase.		hp.json		http://purl.obolibrary.org/obo/HP_0031996		
HP:0031997	biolink:PhenotypicFeature	Early inspiratory crackles	Crackles that appear at the beginning of inspiration and end before mid-inspiration.		hp.json		http://purl.obolibrary.org/obo/HP_0031997		
HP:0031998	biolink:PhenotypicFeature	Late inspiratory crackles	Crackles that appear any time after the beginning of inspiration and last till the end of inspiration.		hp.json		http://purl.obolibrary.org/obo/HP_0031998		
HP:0100219	biolink:PhenotypicFeature	Ivory epiphysis of the middle phalanx of the 5th toe		UMLS:C4022202	hp.json	Increased bone density of end part of the middle bone of the pinkie toe|Increased bone density of end part of the middle bone of the pinky toe|Increased bone density of end part of the middle bone of the little toe	http://purl.obolibrary.org/obo/HP_0100219		
GO:0017085	biolink:BiologicalProcess	response to insecticide	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects.		hp.json	insecticide susceptibility/resistance|insecticide resistance	http://purl.obolibrary.org/obo/GO_0017085		
HP:0100217	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the middle phalanx of the 5th toe		UMLS:C4022204	hp.json	Fragmentation of the end part of the middle bone of the little toe|Fragmentation of the end part of the middle bone of the pinkie toe|Fragmentation of the end part of the middle bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100217		
HP:0100218	biolink:PhenotypicFeature	Irregular epiphysis of the middle phalanx of the 5th toe		UMLS:C4022203	hp.json	Irregular end part of the middle bone of the little toe|Irregular end part of the middle bone of the pinkie toe|Irregular end part of the middle bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100218		
HP:0100226	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022195	hp.json	Cone-shaped end part of the innermost bone of the pinky toe|Cone-shaped end part of the innermost bone of the little toe|Cone-shaped end part of the innermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100226		
HP:0100227	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022194	hp.json	Enlarged end part of the innermost bone of the pinkie toe|Enlarged end part of the innermost bone of the pinky toe|Enlarged end part of the innermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100227		
HP:0100224	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022197	hp.json	Absent end part of the innermost bone of the little toe|Absent end part of the innermost bone of the pinkie toe|Absent end part of the innermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100224		
HP:0100225	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022196	hp.json	Bracket shaped end part of the innermost bone of the little toe|Bracket shaped end part of the innermost bone of the pinky toe|Bracket shaped end part of the innermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100225		
HP:0100222	biolink:PhenotypicFeature	Stippling of the epiphysis of the middle phalanx of the 5th toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 5th toe.	UMLS:C4022199	hp.json	Speckled calcifications in end part of the innermost bone of the pinkie toe|Speckled calcifications in middle part of the innermost bone of the little toe|Speckled calcifications in middle part of the innermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100222		
HP:0100223	biolink:PhenotypicFeature	Triangular epiphysis of the middle phalanx of the 5th toe		UMLS:C4022198	hp.json	Triangular end part of the middle bone of the pinkie toe|Triangular end part of the middle bone of the pinky toe|Triangular end part of the middle bone of the little toe	http://purl.obolibrary.org/obo/HP_0100223		
HP:0100220	biolink:PhenotypicFeature	Pseudoepiphysis of the middle phalanx of the 5th toe	A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the middle phalanx of the fifth toe.	UMLS:C4022201	hp.json		http://purl.obolibrary.org/obo/HP_0100220		
HP:0100221	biolink:PhenotypicFeature	Small epiphysis of the middle phalanx of the 5th toe		UMLS:C4022200	hp.json	Small end part of the middle bone of the pinkie toe|Small end part of the middle bone of the pinky toe|Small end part of the middle bone of the little toe	http://purl.obolibrary.org/obo/HP_0100221		
GO:0030036	biolink:BiologicalProcess	actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.		hp.json	actin cytoskeleton organization and biogenesis|actin cytoskeleton organisation|actin modulating activity	http://purl.obolibrary.org/obo/GO_0030036		goslim_pombe
GO:0030031	biolink:BiologicalProcess	cell projection assembly	Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.		hp.json	cell projection biogenesis|formation of a cell surface projection	http://purl.obolibrary.org/obo/GO_0030031		
HP:0100228	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022193	hp.json	Fragmentation of the end part of the innermost bone of the pinky toe|Fragmentation of the end part of the innermost bone of the pinkie toe|Fragmentation of the end part of the innermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100228		
GO:0030030	biolink:BiologicalProcess	cell projection organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.		hp.json	cell surface structure organization and biogenesis|cell projection organisation|cell projection organization and biogenesis	http://purl.obolibrary.org/obo/GO_0030030		
HP:0100229	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022192	hp.json	Irregular end part of the innermost bone of the pinky toe|Irregular end part of the innermost bone of the pinkie toe|Irregular end part of the innermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100229		
HP:0100237	biolink:PhenotypicFeature	Proximal foot symphalangism		UMLS:C4022185	hp.json		http://purl.obolibrary.org/obo/HP_0100237		
CHEBI:139590	biolink:ChemicalSubstance	primary alpha-hydroxy ketone	An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a -CH2 (methylene) group.		hp.json	primary alpha-hydroxy ketones|primary alpha-hydroxy-ketone|primary alpha-hydroxyketones|primary alpha-hydroxyketone|primary alpha-hydroxy-ketones	http://purl.obolibrary.org/obo/CHEBI_139590		3_STAR
HP:0100238	biolink:PhenotypicFeature	Synostosis involving bones of the upper limbs	An abnormal union between bones or parts of bones of the upper limbs.	UMLS:C4022184	hp.json	Fusion involving bones of the upper limbs	http://purl.obolibrary.org/obo/HP_0100238		
HP:0100235	biolink:PhenotypicFeature	Synostosis involving bones of the toes		UMLS:C4022186	hp.json	Fusion involving bones of the toes	http://purl.obolibrary.org/obo/HP_0100235		
CHEBI:139592	biolink:ChemicalSubstance	tertiary alpha-hydroxy ketone	An alpha-hydroxy ketone in which the carbonyl group and the hydroxy group are linked by a carbon bearing two organyl groups.		hp.json	tertiary alpha-hydroxy-ketones|tertiary alpha-hydroxy ketones|tertiary alpha-hydroxy-ketone|tertiary alpha-hydroxyketones|tertiary alpha-hydroxyketone	http://purl.obolibrary.org/obo/CHEBI_139592		3_STAR
HP:0100233	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the 5th toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 5th toe.	UMLS:C4022188	hp.json	Speckled calcifications in the end part of the innermost bone of the pinkie toe|Speckled calcifications in the end part of the innermost bone of the pinky toe|Speckled calcifications in the end part of the innermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100233		
GO:0030029	biolink:BiologicalProcess	actin filament-based process	Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.		hp.json	microfilament-based process	http://purl.obolibrary.org/obo/GO_0030029		
HP:0100234	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022187	hp.json	Triangular end part of the innermost bone of the pinkie toe|Triangular end part of the innermost bone of the pinky toe|Triangular end part of the innermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100234		
HP:0100231	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the 5th toe	A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the fifth toe.	UMLS:C4022190	hp.json		http://purl.obolibrary.org/obo/HP_0100231		
HP:0100232	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022189	hp.json	Small end part of the innermost bone of the pinkie toe|Small end part of the innermost bone of the pinky toe|Small end part of the innermost bone of the little toe	http://purl.obolibrary.org/obo/HP_0100232		
OBO:uberon/core#transitively_distally_connected_to	biolink:NamedThing	transitively distally connected to	.		hp.json		http://purl.obolibrary.org/obo/uberon/core#transitively_distally_connected_to		
HP:0100230	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022191	hp.json	Increased bone density of end part of the innermost bone of the pinky toe|Increased bone density of end part of the innermost bone of the little toe|Increased bone density of end part of the innermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100230		
CHEBI:139588	biolink:ChemicalSubstance	alpha-hydroxy ketone	An alpha-oxyketone that has a hydroxy group as the alpha-oxy moiety.	PMID:23295224|PMID:15326516|PMID:20382022|PMID:19908854	hp.json	alpha-hydroxyketone|alpha-hydroxy-ketones|alpha-hydroxy ketones|alpha-hydroxy-ketone|alpha-hydroxyketones	http://purl.obolibrary.org/obo/CHEBI_139588		3_STAR
NBO:0000493	biolink:NamedThing	parasomnia	"A sleeping behavior phenotype that involve abnormal and unnatural movements, emotions, perceptions, and dreams that occur while falling asleep, sleeping, between sleep stages, or during arousal from sleep." [wikipedia:Parasomnia]		hp.json		http://purl.obolibrary.org/obo/NBO_0000493		
GO:0032682	biolink:BiologicalProcess	negative regulation of chemokine production	Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production.		hp.json	down regulation of chemokine production|inhibition of chemokine production|down-regulation of chemokine production|negative regulation of chemokine biosynthetic process|downregulation of chemokine production|negative regulation of chemokine secretion	http://purl.obolibrary.org/obo/GO_0032682		
HP:0004319	biolink:PhenotypicFeature	Decreased circulating aldosterone level	Abnormally reduced levels of aldosterone.	SNOMEDCT_US:60086000|UMLS:C0020595|MSH:D006994|UMLS:C0857899|UMLS:C1846226	hp.json	Mineralocorticoid insufficiency|Decreased aldosterone production|Decreased serum aldosterone|Low blood aldosterone level|Hypoaldosteronism|Decreased aldosterone	http://purl.obolibrary.org/obo/HP_0004319		
UBERON:0004264	biolink:AnatomicalEntity	lower leg skin	A zone of skin that is part of a lower leg [Automatically generated definition].	EMAPA:18156|MA:0000680	hp.json	hind limb zeugopod skin|hind limb middle limb segment skin	http://purl.obolibrary.org/obo/UBERON_0004264		
HP:0031944	biolink:PhenotypicFeature	Pleural thickening	An increase in the thickness of the pleura, generally related to scarring of the pleural tissue.		hp.json	Pleural incrassation	http://purl.obolibrary.org/obo/HP_0031944		
HP:0006977	biolink:PhenotypicFeature	Grammar-specific speech disorder		UMLS:C4024956	hp.json	Grammar-specific speech disorder	http://purl.obolibrary.org/obo/HP_0006977		
HP:0004313	biolink:PhenotypicFeature	Decreased circulating antibody level	An abnormally decreased level of immunoglobulin in blood.	MSH:D000361|SNOMEDCT_US:119250001|UMLS:C4048270|UMLS:C0086438	hp.json	Decreased immunoglobulin level|Decreased antibody level in blood|Reduced immunoglobulin levels|Hypogammaglobulinemia|Immunoglobulin deficiency|Decreased serum immunoglobulin	http://purl.obolibrary.org/obo/HP_0004313		
HP:0006978	biolink:PhenotypicFeature	Dysmyelinating leukodystrophy		UMLS:C3278204	hp.json		http://purl.obolibrary.org/obo/HP_0006978		
UBERON:0004265	biolink:AnatomicalEntity	outflow tract myocardium	A myocardium that is part of a outflow tract [Automatically generated definition].	MA:0000489|EHDAA2:0001358|VHOG:0000603|EMAPA:35623	hp.json	cardiac muscle of outflow tract|heart myocardium of outflow tract|outflow tract muscle of heart|heart muscle of outflow tract|outflow tract heart muscle|muscle of heart of outflow tract|myocardium of outflow tract|outflow tract heart myocardium|outflow tract cardiac muscle	http://purl.obolibrary.org/obo/UBERON_0004265		
HP:0031945	biolink:PhenotypicFeature	Elevated circulating N,N-dimethylglycine concentration	An increased concentration of N,N-dimethylglycine in the circulation.		hp.json	Elevated N,N-dimethylglycine level	http://purl.obolibrary.org/obo/HP_0031945		
HP:0004312	biolink:PhenotypicFeature	Abnormal reticulocyte morphology	A reticulocyte abnormality.	UMLS:C4025358	hp.json	Abnormality of reticulocytes	http://purl.obolibrary.org/obo/HP_0004312		
UBERON:0004262	biolink:AnatomicalEntity	upper leg skin	A zone of skin that is part of a hindlimb stylopod [Automatically generated definition].	EMAPA:18159|MA:0000686|FMA:37790	hp.json	thigh skin|hind limb stylopod skin|skin of thigh|hindlimb stylopod skin|skin of upper leg	http://purl.obolibrary.org/obo/UBERON_0004262		
HP:0031946	biolink:PhenotypicFeature	Elevated urinary N,N-dimethylglycine level	An increased concentration of N,N-dimethylglycine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031946		
HP:0006979	biolink:PhenotypicFeature	Sleep-wake cycle disturbance	Any abnormal alteration of an individual's circadian rhythm that affects the timing of sleeping and being awake.	UMLS:C1833362	hp.json	Sleep-wake cycle disturbance	http://purl.obolibrary.org/obo/HP_0006979		
UBERON:0004263	biolink:AnatomicalEntity	upper arm skin	A zone of skin that is part of a forelimb stylopod [Automatically generated definition].	FMA:37721|MA:0000608|EMAPA:18062	hp.json	skin of arm stylopod|arm stylopod skin|skin of upper arm	http://purl.obolibrary.org/obo/UBERON_0004263		
HP:0004311	biolink:PhenotypicFeature	Abnormal macrophage morphology	An abnormality of macrophages.	UMLS:C4021661	hp.json	Abnormality of macrophages|Abnormality of histiocytes	http://purl.obolibrary.org/obo/HP_0004311		
HP:0031947	biolink:PhenotypicFeature	Tongue tremor	An unintentional, oscillating to-and-fro muscle movement affecting the tongue.		hp.json	Jerky movements of the tongue	http://purl.obolibrary.org/obo/HP_0031947		
UBERON:0004260	biolink:AnatomicalEntity	upper arm blood vessel	A blood vessel that is part of a forelimb stylopod [Automatically generated definition].	EMAPA:37294|MA:0000603	hp.json	forelimb stylopod blood vessel	http://purl.obolibrary.org/obo/UBERON_0004260		
HP:0031941	biolink:PhenotypicFeature	Abnormal portal venous system morphology	Any structural anomaly of the portal venous sytem, which comprises all of the veins draining the abdominal part of the digestive tract, including the lower esophagus but excluding the lower anal canal. The portal vein conveys blood from viscera and ramifies like an artery at the liver, ending at the sinusoids. Tributaries of the portal vein, which make up the portal venous system, are the splenic, superior mesenteric, left gastric, right gastric, paraumbilical, and cystic veins.		hp.json		http://purl.obolibrary.org/obo/HP_0031941		
UBERON:0004261	biolink:AnatomicalEntity	lower leg blood vessel	A blood vessel that is part of a lower leg [Automatically generated definition].	MA:0000675|EMAPA:37300	hp.json	hindlimb zeugopod blood vessel	http://purl.obolibrary.org/obo/UBERON_0004261		
HP:0031942	biolink:PhenotypicFeature	Congenital absence of portal vein	Anomaly where the intestinal and the splenic venous drainage bypass the liver and drain into systemic veins through other possible venous shunts.		hp.json	Missing portal vein|CAPV	http://purl.obolibrary.org/obo/HP_0031942		
HP:0006976	biolink:PhenotypicFeature	Necrotizing encephalopathy	A type of encephalopathy (brain disease, damage, or malfunction accompanied by an altered mental state) that is characterized by evidence of necrosis of brain tissue.	UMLS:C1396481	hp.json		http://purl.obolibrary.org/obo/HP_0006976		
HP:0004315	biolink:PhenotypicFeature	Decreased circulating IgG level	An abnormally decreased level of immunoglobulin G (IgG) in blood.	SNOMEDCT_US:190981001|SNOMEDCT_US:123785006|UMLS:C0162539|MSH:D017099	hp.json	Decreased immunoglobulin G|IgG deficiency|Decreased IgG level in blood|Decreased gamma-globin expression|Reduced IgG levels|Decreased serum IgG|Decreased IgG level	http://purl.obolibrary.org/obo/HP_0004315		
HP:0031943	biolink:PhenotypicFeature	Akathisia	A state of motor restlessness, usually in the lower extremities, that is often but not always accompanied by a subjective sense of inner restlessness, an urge to move, and anxiety or dysphoria.		hp.json		http://purl.obolibrary.org/obo/HP_0031943		
HP:0006970	biolink:PhenotypicFeature	Periventricular leukomalacia	Periventricular leukomalacia is characterized by diffuse injury of deep cerebral white matter, accompanied in its most severe form by focal necrosis. The neuropathologic hallmarks of PVL are microglial activation and focal and diffuse periventricular depletion of premyelinating oligodendroglia.	SNOMEDCT_US:230769007|UMLS:C0023529|MSH:D007969	hp.json	PVL	http://purl.obolibrary.org/obo/HP_0006970		
PR:P22304	biolink:Protein	iduronate 2-sulfatase (human)	An iduronate 2-sulfatase that is encoded in the genome of human.	UniProtKB:P22304	hp.json	IDS|alpha-L-iduronate sulfate sulfatase (human)|SIDS|idursulfase (human)|hIDS	http://purl.obolibrary.org/obo/PR_P22304		
HP:0031948	biolink:PhenotypicFeature	Snowball lesion of corpus callosum	Centrally located corpus callosum hyperintensities said to resemble snowballs upon magnetic resonance imaging (with T2 or Sagittal fluid attenuated inversion recovery [FLAIR] sequences). The central location in the callosum makes them pathognomonic for Susac syndrome.		hp.json		http://purl.obolibrary.org/obo/HP_0031948		
UBERON:0004268	biolink:AnatomicalEntity	lower arm connective tissue	A portion of connective tissue that is part of a lower arm [Automatically generated definition].	MA:0000599|EMAPA:37319	hp.json		http://purl.obolibrary.org/obo/UBERON_0004268		
UBERON:0004269	biolink:AnatomicalEntity	upper arm connective tissue	A portion of connective tissue that is part of a forelimb stylopod [Automatically generated definition].	MA:0000605|EMAPA:37317	hp.json		http://purl.obolibrary.org/obo/UBERON_0004269		
HP:0031949	biolink:PhenotypicFeature	Recurrent bacterial upper respiratory tract infections	An increased susceptibility to bacterial upper respiratory tract infections as manifested by a history of recurrent bacterial upper respiratory tract infections (running ears - otitis, sinusitis, pharyngitis, tonsillitis).		hp.json	Recurrent bacterial URI	http://purl.obolibrary.org/obo/HP_0031949		
UBERON:0004266	biolink:AnatomicalEntity	upper leg connective tissue	A portion of connective tissue that is part of a hindlimb stylopod [Automatically generated definition].	MA:0000683|EMAPA:37325	hp.json		http://purl.obolibrary.org/obo/UBERON_0004266		
UBERON:0004267	biolink:AnatomicalEntity	back connective tissue	A portion of connective tissue that is part of a back [Automatically generated definition].	EMAPA:37256|MA:0000495	hp.json	mesenchyne of back	http://purl.obolibrary.org/obo/UBERON_0004267		
CHEBI:33405	biolink:ChemicalSubstance	hydracid	A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).		hp.json	hydracid|hydracids	http://purl.obolibrary.org/obo/CHEBI_33405		3_STAR
HP:0031950	biolink:PhenotypicFeature	Usual interstitial pneumonia	Temporal and spatial heterogeneity in lungs based on presence of fibrosis and honeycombing.		hp.json		http://purl.obolibrary.org/obo/HP_0031950		
CHEBI:33408	biolink:ChemicalSubstance	pnictogen oxoacid			hp.json	pnictogen oxoacids	http://purl.obolibrary.org/obo/CHEBI_33408		3_STAR
HP:0004325	biolink:PhenotypicFeature	Decreased body weight	Abnormally low body weight.	UMLS:C1262477|UMLS:C1844806|MSH:D013851|SNOMEDCT_US:89362005|SNOMEDCT_US:262285001|MSH:D015431|SNOMEDCT_US:248342006|UMLS:C0041667|SNOMEDCT_US:161832001	hp.json	Low body weight|Weight less than 3rd percentile|Low weight|Decreased weight|Decreased body weight	http://purl.obolibrary.org/obo/HP_0004325		
HP:0006988	biolink:PhenotypicFeature	Alobar holoprosencephaly	A type of holoprosencephaly characterized by the presence of a single ventricle and no separation of the cerebral hemisphere. The single midline ventricle is often greatly enlarged.	SNOMEDCT_US:253137003|UMLS:C0431363|MSH:D016142	hp.json		http://purl.obolibrary.org/obo/HP_0006988		
UBERON:0004253	biolink:AnatomicalEntity	skin muscle	Any muscle organ that is part of a skin of body [Automatically generated definition].	EMAPA:35776|MA:0002710|MA:0003139|EMAPA:18187	hp.json	skin muscle organ|integumental system muscle|muscle of integumental system|muscle organ of skin	http://purl.obolibrary.org/obo/UBERON_0004253		
HP:0031955	biolink:PhenotypicFeature	Antalgic gait	To avoid pain weight is put on the affected leg for as short a time as possible, resulting in a limp. The patients appear to be walking as if there were a thorn in the sole of the foot. To reduce the load on the affected leg the patients lift and lower their foot in a fixed ankle position.		hp.json	Limp	http://purl.obolibrary.org/obo/HP_0031955		
UBERON:0004254	biolink:AnatomicalEntity	forelimb zeugopod muscle	Any muscle organ that is part of a forelimb zeugopod (lower arm)[Automatically generated definition].	MA:0000600|FMA:37371|EMAPA:32622	hp.json	lower arm muscle|wing zeugopod muscle|muscle of forearm|forearm muscle	http://purl.obolibrary.org/obo/UBERON_0004254		
HP:0006989	biolink:PhenotypicFeature	Dysplastic corpus callosum	Dysplasia and dysgenesis of the corpus callosum are nonspecific descriptions that imply defective development of the corpus callosum. The term dysplasia is applied when the morphology of the corpus callosum is altered as a congenital trait. For instance, the corpus callosum may be hump-shaped, kinked, or a striped corpus callosum that lacks an anatomically distinct genu and splenium.	UMLS:C0431369	hp.json	Dysgenesis of corpus callosum|Dysplasia of corpus callosum	http://purl.obolibrary.org/obo/HP_0006989		
HP:0004324	biolink:PhenotypicFeature	Increased body weight	Abnormally increased body weight.	SNOMEDCT_US:8943002|MSH:D015430|SNOMEDCT_US:161831008|SNOMEDCT_US:262286000|UMLS:C0043094	hp.json	Increased body weight|Weight gain	http://purl.obolibrary.org/obo/HP_0004324		
HP:0031956	biolink:PhenotypicFeature	Elevated circulating aspartate aminotransferase concentration	An abnormally high concentration in the circulation of aspartate aminotransferase (AST).		hp.json	Aspartate aminotransferase increased|Elevated serum AST|Elevated serum glutamic oxaloacetic transaminase|Elevated serum aspartate aminotransferase	http://purl.obolibrary.org/obo/HP_0031956		
UBERON:0004251	biolink:AnatomicalEntity	hindlimb zeugopod bone	A bone that is part of a lower leg [Automatically generated definition].	MA:0000676|EMAPA:35519	hp.json	bone of middle limb segment of hindlimb|zeugopod of hind limb bone|bone of zeugopod of leg|zeugopod of inferior member bone organ|bone organ of inferior member zeugopod|bone of hind limb zeugopod|intermediate segment of free lower limb bone organ|intermediate segment of free lower limb bone|bone of inferior member zeugopod|bone organ of middle limb segment of hindlimb|zeugopod of inferior member bone|bone organ of zeugopod of leg|bone of intermediate segment of free lower limb|middle limb segment of hind limb bone organ|middle limb segment of hindlimb bone organ|zeugopod of leg bone organ|bone of zeugopod of inferior member|bone organ of zeugopod of hindlimb|zeugopod of leg bone|middle limb segment of inferior member bone organ|bone of zeugopod of hind limb|middle limb segment of hind limb bone|bone organ of intermediate segment of free lower limb|bone of lower leg|middle limb segment of hindlimb bone|bone organ of zeugopod of inferior member|bone of zeugopod of hindlimb|middle limb segment of inferior member bone|bone organ of lower leg|bone organ of zeugopod of hind limb|bone organ of middle limb segment of inferior member|zeugopod of hindlimb bone organ|bone of middle limb segment of inferior member|bone organ of middle limb segment of hind limb|bone of middle limb segment of hind limb|zeugopod of hindlimb bone|lower extremity middle limb segment bone organ|bone of inferior member middle limb segment|lower extremity middle limb segment bone|inferior member zeugopod bone organ|bone of hind limb middle limb segment|bone organ of inferior member middle limb segment|bone organ of hind limb middle limb segment|bone of zeugopod of lower extremity|bone of hindlimb zeugopod|inferior member zeugopod bone|hind limb zeugopod bone organ|bone organ of hindlimb zeugopod|hind limb zeugopod bone|bone organ of zeugopod of lower extremity|hindlimb middle limb segment bone organ|hindlimb middle limb segment bone|bone organ of middle limb segment of lower extremity|bone organ of lower extremity zeugopod|hindlimb zeugopod bone organ|zeugopod of lower extremity bone organ|zeugopod of lower extremity bone|bone of middle limb segment of lower extremity|bone of lower extremity zeugopod|hindlimb zeugopod bone|hind limb middle limb segment bone organ|inferior member middle limb segment bone organ|hind limb middle limb segment bone|bone of lower extremity middle limb segment|inferior member middle limb segment bone|middle limb segment of lower extremity bone organ|bone organ of lower extremity middle limb segment|lower extremity zeugopod bone organ|lower leg bone|bone organ of hindlimb middle limb segment|lower extremity zeugopod bone|middle limb segment of lower extremity bone|bone of hindlimb middle limb segment|zeugopod of hind limb bone organ|bone organ of hind limb zeugopod	http://purl.obolibrary.org/obo/UBERON_0004251		
HP:0004323	biolink:PhenotypicFeature	Abnormality of body weight	An abnormal increase or decrease of weight or an abnormal distribution of mass in the body.	UMLS:C4025357|UMLS:C0878621	hp.json	Abnormality of habitus|Abnormality of body weight	http://purl.obolibrary.org/obo/HP_0004323		
HP:0031957	biolink:PhenotypicFeature	Spastic hemiparetic gait	Spastic hemiparesis is characterized by a dominance of the tonus in the upper limb flexor muscles: the arm is held in an adducted posture and is bent and rotated inwards, the forearm is pronated and the hand and the fingers are flexed. The leg is slightly bent at the hip, the knee cannot be extended fully at the end of the stance phase and the foot is inverted and in a plantar flexed position. Gait is slow, with a wide base and asymmetrical with a shortened weight-bearing phase on the paretic side. During the swing phase, the paretic leg performs a lateral movement (circumduction) which is characteristic of this gait disorder, also termed Wernicke-Mann gait. Spastic gait problems typically worsen on attempts to walk faster.		hp.json	Wernicke-Mann gait	http://purl.obolibrary.org/obo/HP_0031957		
UBERON:0004252	biolink:AnatomicalEntity	hindlimb stylopod muscle	Any muscle organ that is part of a hindlimb stylopod (upper leg)[Automatically generated definition].	FMA:22470|MA:0000684|EMAPA:19144|BTO:0001367	hp.json	upper leg muscle|muscle of thigh|thigh muscle	http://purl.obolibrary.org/obo/UBERON_0004252		pheno_slim
HP:0031958	biolink:PhenotypicFeature	Spastic paraparetic gait	A type of spastic gait in which the legs are usually slightly bent at the hip and in an adducted position. The knees are extended or slightly bent and the feet are in a plantar flexion position. This posture requires circumduction of the legs during walking. The gait may appear stiff (spastic gait disorder) or stiff as well as insecure (spastic ataxic gait disorder). In spastic paraparetic gait, each leg appears to be dragged forward. If the muscle tone in the adductors is marked, the resulting gait disorder is referred to as scissor gait.		hp.json		http://purl.obolibrary.org/obo/HP_0031958		
HP:0004322	biolink:PhenotypicFeature	Short stature	A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms).	SNOMEDCT_US:237836003|UMLS:C0349588	hp.json	Height less than 3rd percentile|Short stature|Stature below 3rd percentile|Small stature|Decreased body height	http://purl.obolibrary.org/obo/HP_0004322		
HP:0031951	biolink:PhenotypicFeature	Nocturnal seizures	Seizures that occur while the affected individual is sleeping.		hp.json	Sleep seizures	http://purl.obolibrary.org/obo/HP_0031951		
HP:0004329	biolink:PhenotypicFeature	Abnormal posterior eye segment morphology		UMLS:C4025354	hp.json	Abnormality of the posterior segment of the globe|Abnormal morphology of the posterior segment of the globe|Abnormality of the posterior segment of the eye|Abnormality of the posterior segment of the eyeball	http://purl.obolibrary.org/obo/HP_0004329		
HP:0006984	biolink:PhenotypicFeature	obsolete Distal sensory loss of all modalities			hp.json		http://purl.obolibrary.org/obo/HP_0006984		
UBERON:0004250	biolink:AnatomicalEntity	upper arm bone	A bone that is part of a forelimb stylopod [Automatically generated definition].	MA:0000604|EMAPA:35892	hp.json	humerus	http://purl.obolibrary.org/obo/UBERON_0004250		
GO:0140572	biolink:BiologicalProcess	vacuole fission	The division of a vacuole within a cell to form two or more separate vacuoles.		hp.json		http://purl.obolibrary.org/obo/GO_0140572		
HP:0031952	biolink:PhenotypicFeature	Neurogenic claudication	Lumbar spinal stenoses may induce symptoms following an individually typical latency on standing or when walking due to swelling of the cauda equina, which leads to compression. This is referred to as neurogenic claudication. The symptoms of lumbar spinal stenosis can be explained by an increase in lumbar lordosis and spinal canal stenosis in an upright position compared to the sitting position or if spondylolisthesis is present by a shift of the vertebrae while standing and walking. Following an individually characteristic distance, walking becomes associated with deep muscular pain and with neurological deficits, such as sensory deficits and paresis in the lower limbs, which resolve within minutes when the affected person sits or lies down. Activities performed in a flexed posture, such as cycling often cause less problems than walking. For the same reason, walking uphill may be tolerated better than walking downhill. Clinical neurological examination at rest may be entirely normal but there is usually pain on hyperextension of the lumbar spine.		hp.json		http://purl.obolibrary.org/obo/HP_0031952		
HP:0004328	biolink:PhenotypicFeature	Abnormal anterior eye segment morphology	An abnormality of the anterior segment of the eyeball (which comprises the structures in front of the vitreous humour: the cornea, iris, ciliary body, and lens).	UMLS:C4025355	hp.json	Abnormality of the anterior segment of the eye|Abnormality of the anterior segment of the eyeball|Abnormality of the anterior segment of the globe|Abnormal anterior segment morphology	http://purl.obolibrary.org/obo/HP_0004328		
HP:0004327	biolink:PhenotypicFeature	Abnormal vitreous humor morphology	Any structural anomaly of the vitreous body.	UMLS:C4025356	hp.json	Abnormal vitreous humour morphology	http://purl.obolibrary.org/obo/HP_0004327		hposlim_core
HP:0006986	biolink:PhenotypicFeature	Upper limb spasticity		UMLS:C1273957|SNOMEDCT_US:394680009	hp.json	Uncontrollable movement in upper arms	http://purl.obolibrary.org/obo/HP_0006986		
HP:0031953	biolink:PhenotypicFeature	Cautious gait	Cautious gait refers to an excessive degree of age-related changes in walking and fear of falling. The walking difficulties seem out of proportion when considering the patient's actual sensory or motor deficits. The gait appears slow, with a wider base than normal, reduced arm swing bilaterally and a slightly stooped posture. This type of gait change often occurs after the first time a patient has fallen.		hp.json	Senile gait	http://purl.obolibrary.org/obo/HP_0031953		
CHEBI:33402	biolink:ChemicalSubstance	sulfur oxoacid			hp.json	sulfur oxoacids|oxoacids of sulfur	http://purl.obolibrary.org/obo/CHEBI_33402		3_STAR
HP:0004326	biolink:PhenotypicFeature	Cachexia	Severe weight loss, wasting of muscle, loss of appetite, and general debility related to a chronic disease.	SNOMEDCT_US:238108007|SNOMEDCT_US:285384003|UMLS:C0006625|MSH:D002100	hp.json	Wasting syndrome	http://purl.obolibrary.org/obo/HP_0004326		
HP:0031954	biolink:PhenotypicFeature	Dystonic gait	Dystonic gait disorders frequently appear bizarre, particularly because activity increases dystonic tonus and posture. The abnormal posture of the foot in dystonic gait typically involves inversion, plantar flexion and tonic extension of the big toe. In many patients complex types of walking, such as walking backwards and running are paradoxically less impaired than walking forward and may seem completely unaffected. Sensory tricks, for instance, if the affected individual rests a hand on his or her neck, may improve or even normalize dystonic gait in some patients.		hp.json		http://purl.obolibrary.org/obo/HP_0031954		
HP:0006980	biolink:PhenotypicFeature	Progressive leukoencephalopathy	Leukoencephalopathy that gets more severe with time.	UMLS:C1855010	hp.json	Leukoencephalopathy, progressive	http://purl.obolibrary.org/obo/HP_0006980		
UBERON:0004259	biolink:AnatomicalEntity	lower arm blood vessel	A blood vessel that is part of a lower arm [Automatically generated definition].	EMAPA:37295|MA:0000597	hp.json	forelimb zeugopod blood vessel	http://purl.obolibrary.org/obo/UBERON_0004259		
HP:0006983	biolink:PhenotypicFeature	obsolete Slowly progressive spastic quadriparesis			hp.json		http://purl.obolibrary.org/obo/HP_0006983		
HP:0004321	biolink:PhenotypicFeature	Bladder fistula	The presence of a fistula connecting the urinary bladder to another organ or the skin. The fistula can involve the bowel, the vagina, or rarely, the skin.	MSH:D001747|SNOMEDCT_US:68666001|UMLS:C0005690	hp.json		http://purl.obolibrary.org/obo/HP_0004321		
UBERON:0004257	biolink:AnatomicalEntity	upper leg blood vessel	A blood vessel that is part of a hindlimb stylopod [Automatically generated definition].	EMAPA:37299|MA:0000681	hp.json	thigh blood vessel|blood vessel of stylopod of hind limb|blood vessel of thigh|blood vessel of stylopod of hindlimb|hind limb stylopod blood vessel|hindlimb stylopod blood vessel|blood vessel of upper leg	http://purl.obolibrary.org/obo/UBERON_0004257		
HP:0031959	biolink:PhenotypicFeature	Leg dystonia	A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the legs.		hp.json		http://purl.obolibrary.org/obo/HP_0031959		
UBERON:0004258	biolink:AnatomicalEntity	back blood vessel	A blood vessel that is part of a back [Automatically generated definition].	MA:0000493|EMAPA:37243	hp.json	blood vessel of back	http://purl.obolibrary.org/obo/UBERON_0004258		
HP:0004320	biolink:PhenotypicFeature	Vaginal fistula	The presence of a fistula of the vagina.	UMLS:C0042253|SNOMEDCT_US:45135002|MSH:D014624	hp.json		http://purl.obolibrary.org/obo/HP_0004320		
UBERON:0004255	biolink:AnatomicalEntity	forelimb stylopod muscle	Any muscle organ that is part of a forelimb stylopod (upper arm)[Automatically generated definition].	MA:0000606|EMAPA:19107|FMA:37370	hp.json	muscle of arm|muscle of upper arm|upper arm muscle|skeletal muscle of upper arm|wing stylopod muscle	http://purl.obolibrary.org/obo/UBERON_0004255		pheno_slim
UBERON:0004256	biolink:AnatomicalEntity	hindlimb zeugopod muscle	Any muscle organ that is part of a hindlimb zeugopod (lower leg) [Automatically generated definition].	EMAPA:19318|MA:0000678|FMA:22471	hp.json	calf muscle|lower leg muscle|muscle of leg	http://purl.obolibrary.org/obo/UBERON_0004256		pheno_slim
HP:0031960	biolink:PhenotypicFeature	Arm dystonia	A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the arms.		hp.json		http://purl.obolibrary.org/obo/HP_0031960		
HP:0031961	biolink:PhenotypicFeature	Abnormal serum anion gap	Any deviation from the normal value of the serum anion gap, which is calculated from the electrolytes measured in the chemical laboratory, is defined as the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration.		hp.json		http://purl.obolibrary.org/obo/HP_0031961		
HP:0006959	biolink:PhenotypicFeature	Proximal spinal muscular atrophy	Proximal spinal muscular atrophy, i.e., muscular weakness and atrophy related to loss of the motor neurons of the spinal cord and brainstem.	UMLS:C4024957	hp.json		http://purl.obolibrary.org/obo/HP_0006959		
UBERON:0004242	biolink:AnatomicalEntity	bronchus smooth muscle	A portion of smooth muscle tissue that is part of a bronchus [Automatically generated definition].	NCIT:C49213|BTO:0004401|UMLS:C1707055|MA:0001840|EMAPA:35195	hp.json	bronchial trunk smooth muscle|involuntary muscle of bronchi|non-striated muscle of bronchi|involuntary muscle of bronchial trunk|bronchial smooth muscle|non-striated muscle of bronchial trunk|bronchus involuntary muscle|bronchial trunk involuntary muscle|non-striated muscle of bronchus|bronchi involuntary muscle|involuntary muscle of bronchus|bronchus smooth muscle tissue|bronchial trunk smooth muscle tissue|smooth muscle of bronchus|smooth muscle tissue of bronchus|bronchi smooth muscle tissue|bronchi non-striated muscle|bronchial trunk non-striated muscle|smooth muscle tissue of bronchi|smooth muscle of bronchi|bronchus non-striated muscle|smooth muscle tissue of bronchial trunk|bronchi smooth muscle|smooth muscle of bronchial trunk	http://purl.obolibrary.org/obo/UBERON_0004242		human_reference_atlas
HP:0006955	biolink:PhenotypicFeature	Olivopontocerebellar hypoplasia	Hypoplasia of the cerebellum, pontine nuclei, and inferior olivary nucleus.	UMLS:C1859341	hp.json		http://purl.obolibrary.org/obo/HP_0006955		
HP:0006956	biolink:PhenotypicFeature	Lateral ventricle dilatation		UMLS:C1856409	hp.json	Lateral ventricle dilatation|Dilation of lateral ventricles|Enlarged lateral ventricles|Dilatation of lateral cerebral ventricles	http://purl.obolibrary.org/obo/HP_0006956		
UBERON:0004243	biolink:AnatomicalEntity	prostate gland smooth muscle	A portion of smooth muscle tissue that is part of a prostate gland [Automatically generated definition].	EMAPA:35713|FMA:74245|BTO:0003159|MA:0001741	hp.json	prostate smooth muscle|non-striated muscle of prostate gland|involuntary muscle of prostate gland|non-striated muscle of prostate|involuntary muscle of prostate|prostate involuntary muscle|smooth muscle of prostate gland|substantia muscularis prostatae|smooth muscle tissue of prostate gland|smooth muscle of prostate|prostate gland involuntary muscle|smooth muscle tissue of prostate|prostate smooth muscle tissue|muscular tissue of prostate|prostate gland non-striated muscle|prostate gland smooth muscle tissue|prostate non-striated muscle	http://purl.obolibrary.org/obo/UBERON_0004243		
HP:0031967	biolink:PhenotypicFeature	Cloudy urine	The appearance of the urine having visible material in suspension, i.e., appearing cloudy.		hp.json	Turbid urine	http://purl.obolibrary.org/obo/HP_0031967		
UBERON:0004240	biolink:AnatomicalEntity	gall bladder smooth muscle	A portion of smooth muscle tissue that is part of a gallbladder [Automatically generated definition].	UMLS:C1708179|MA:0001635|NCIT:C49483|EMAPA:35373	hp.json	gall bladder non-striated muscle|gall bladder smooth muscle tissue|biliary smooth muscle|gallbladder non-striated muscle|smooth muscle tissue of gallbladder|non-striated muscle of gall bladder|smooth muscle of gallbladder|involuntary muscle of gall bladder|gallbladder smooth muscle|gallbladder involuntary muscle|involuntary muscle of gallbladder|smooth muscle of gall bladder|non-striated muscle of gallbladder|smooth muscle tissue of gall bladder|gall bladder involuntary muscle|gallbladder smooth muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004240		
HP:0006957	biolink:PhenotypicFeature	obsolete Loss of ability to walk			hp.json		http://purl.obolibrary.org/obo/HP_0006957		
HP:0006958	biolink:PhenotypicFeature	Abnormal auditory evoked potentials	An abnormality of the auditory evoked potentials, which are used to trace the signal generated by a sound, from the cochlear nerve, through the lateral lemniscus, to the medial geniculate nucleus, and to the cortex.	SNOMEDCT_US:102971006|UMLS:C0522216	hp.json	Abnormal brainstem auditory-evoked potentials	http://purl.obolibrary.org/obo/HP_0006958		
HP:0031969	biolink:PhenotypicFeature	Reduced blood urea nitrogen	An abnormally low concentration of urea nitrogen in the blood.		hp.json	Reduced BUN	http://purl.obolibrary.org/obo/HP_0031969		
HP:0006951	biolink:PhenotypicFeature	Retrocerebellar cyst		UMLS:C1845370	hp.json		http://purl.obolibrary.org/obo/HP_0006951		
HP:0031962	biolink:PhenotypicFeature	Elevated serum anion gap	An abnormally high value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration).		hp.json		http://purl.obolibrary.org/obo/HP_0031962		
HP:0031963	biolink:PhenotypicFeature	Decreased serum anion gap	An abnormally low value of the serum anion gap (the sum of serum chloride and bicarbonate concentrations subtracted from the serum sodium concentration).		hp.json		http://purl.obolibrary.org/obo/HP_0031963		
HP:0031964	biolink:PhenotypicFeature	Elevated circulating alanine aminotransferase concentration	An abnormally high concentration in the circulation of alanine aminotransferase (ALT).		hp.json	Elevated serum ALT|Alanine aminotransferase increased|Elevated serum alanine aminotransferase|Elevated serum glutamic-pyruvic transaminase	http://purl.obolibrary.org/obo/HP_0031964		
HP:0031965	biolink:PhenotypicFeature	Increased RBC distribution width	Red blood cell distribution width (RDW) is a simple parameter of the standard full blood count and a measure of heterogeneity in the size of circulating erythrocytes. It is provided by automated hematology analyzers and it reflects the range of the red cell size. It is calculated by dividing the standard deviation of erythrocyte volume by the mean corpuscular volume (MCV) and multiplied by 100 to convert to a percentage.		hp.json	Increased red blood cell distribution width	http://purl.obolibrary.org/obo/HP_0031965		
UBERON:0004248	biolink:AnatomicalEntity	pedal digit bone	A bone that is part of a hindlimb digit. Typically phalanges but may include sesamoids.	MA:0000646|EMAPA:37309	hp.json	foot digit bone organ|toe bone|digital bone of pes|foot digit bone|bone of digit of foot|foot digit bone|digital bone of foot|digitus pedis bone organ|digit of foot bone|digitus pedis bone|hind limb digit bone|toe bone organ	http://purl.obolibrary.org/obo/UBERON_0004248		
UBERON:0004249	biolink:AnatomicalEntity	manual digit bone	A bone that is part of a forelimb digit. Typically phalanges but may include sesamoids.	EMAPA:37305|MA:0000622	hp.json	finger bone|hand digit bone|hand digit bone|digital bone of hand|digital bone of manus|fore limb digit bone	http://purl.obolibrary.org/obo/UBERON_0004249		
UBERON:0004246	biolink:AnatomicalEntity	outflow tract smooth muscle	A portion of smooth muscle tissue that is part of a outflow tract [Automatically generated definition].	MA:0000492|EMAPA:37708	hp.json	outflow tract non-striated muscle|outflow tract involuntary muscle|smooth muscle tissue of outflow tract|smooth muscle of outflow tract|outflow tract smooth muscle tissue|involuntary muscle of outflow tract|non-striated muscle of outflow tract	http://purl.obolibrary.org/obo/UBERON_0004246		
UBERON:0004247	biolink:AnatomicalEntity	bone of dorsum	A bone that is part of the dorsal region of an animal.	MA:0000494|EMAPA:37248	hp.json	dorsal region bone|dorsal region bone|back bone|bone of back	http://purl.obolibrary.org/obo/UBERON_0004247		grouping_class
UBERON:0004245	biolink:AnatomicalEntity	oviduct smooth muscle	A portion of smooth muscle tissue that is part of a fallopian tube [Automatically generated definition].	MA:0001721|EMAPA:29046	hp.json	involuntary muscle of fallopian tube|fallopian tube smooth muscle tissue|smooth muscle of fallopian tube|smooth muscle tissue of fallopian tube|fallopian tube non-striated muscle|fallopian tube smooth muscle|fallopian tube involuntary muscle|non-striated muscle of fallopian tube	http://purl.obolibrary.org/obo/UBERON_0004245		
HP:0031970	biolink:PhenotypicFeature	Abnormal blood urea nitrogen concentration	Any deviation from the normal concentration of urea nitrogen in the blood.		hp.json	Abnormal BUN concentration	http://purl.obolibrary.org/obo/HP_0031970		
HP:0004309	biolink:PhenotypicFeature	Ventricular preexcitation	An abnormality in which the cardiac ventricles depolarize too early as a result of an abnormality of cardiac conduction pathways such as an accessory pathway.	SNOMEDCT_US:195060002|UMLS:C0559106	hp.json	Ventricular pre-excitation|Preexcitation|Pre-excitation syndrome	http://purl.obolibrary.org/obo/HP_0004309		
HP:0031971	biolink:PhenotypicFeature	Subaortic ventricular septal bulge	A localized hypertrophy of the subaortic segment of the ventricular septum has been frequently described in elderly persons, and variously termed subaortic ventricular septal bulge (VSB), sigmoid-shaped septum, localized or discrete upper septal hypertrophy.		hp.json		http://purl.obolibrary.org/obo/HP_0031971		
HP:0031972	biolink:PhenotypicFeature	Presyncope	Presyncope is a state of lightheadedness, muscular weakness, blurred vision, and feeling faint. Presyncope is most often cardiovascular in cause.		hp.json		http://purl.obolibrary.org/obo/HP_0031972		
HP:0004308	biolink:PhenotypicFeature	Ventricular arrhythmia		UMLS:C0085612|SNOMEDCT_US:44103008	hp.json	Ventricular arrhythmias	http://purl.obolibrary.org/obo/HP_0004308		
UBERON:0004231	biolink:AnatomicalEntity	anal region smooth muscle	A portion of smooth muscle tissue that is part of an anal region [Automatically generated definition].	EMAPA:37394|MA:0001532	hp.json	anal triangle non-striated muscle|anal part of perineum involuntary muscle|anal region smooth muscle tissue|anal part of perineum non-striated muscle|anal triangle involuntary muscle|smooth muscle tissue of anal triangle|smooth muscle of anal triangle|smooth muscle tissue of anal part of perineum|anal triangle smooth muscle|smooth muscle of anal part of perineum|anal region non-striated muscle|anal part of perineum smooth muscle tissue|anal triangle smooth muscle tissue|anal part of perineum smooth muscle|smooth muscle tissue of anal region|involuntary muscle of anal triangle|involuntary muscle of anal part of perineum|smooth muscle of anal region|non-striated muscle of anal triangle|non-striated muscle of anal part of perineum|involuntary muscle of anal region|non-striated muscle of anal region|anal region involuntary muscle	http://purl.obolibrary.org/obo/UBERON_0004231		
HP:0004303	biolink:PhenotypicFeature	Abnormal muscle fiber morphology	Any abnormality of the skeletal muscle cell. Muscle fibers are subdivided into two types. Type I fibers are fatigue-resistant and rich in oxidative enzymes (they stain light with the myosin ATPase reaction), and type II fibers are fast-contracting, fatigue-prone, and rich in glycolytic enzymes (these fibers stain darkly). Normal muscle tissue has a random distribution of type I and type II fibers.	UMLS:C4021663	hp.json	Abnormality of muscle fibres|Abnormal muscle fibre morphology|Abnormal skeletal muscle fiber morphology|Abnormal skeletal muscle fibre morphology|Abnormality of muscle fibers	http://purl.obolibrary.org/obo/HP_0004303		
HP:0031977	biolink:PhenotypicFeature	Increased vertical cup-to-disc ratio - 0.9	Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.9 (The normal cup-to-disc ratio is 0.3).		hp.json		http://purl.obolibrary.org/obo/HP_0031977		
UBERON:0004232	biolink:AnatomicalEntity	lymphatic vessel smooth muscle	A portion of smooth muscle tissue that is part of a lymphatic vessel [Automatically generated definition].	FMA:262026|EMAPA:36313|NCIT:C49260|UMLS:C1708791|MA:0000751	hp.json	smooth muscle tissue of lymph vessel|lymphatic vessel non-striated muscle|lymph vessel involuntary muscle|lymphatic vessel involuntary muscle|lymph vessel non-striated muscle|lymph vessel smooth muscle tissue|non-striated muscle of lymphatic vessel|lymph vessel smooth muscle|lymphatic vessel smooth muscle tissue|involuntary muscle of lymphatic vessel|non-striated muscle of lymph vessel|smooth muscle of lymphatic vessel|involuntary muscle of lymph vessel|smooth muscle tissue of lymphatic vessel|smooth muscle of lymph vessel	http://purl.obolibrary.org/obo/UBERON_0004232		pheno_slim
HP:0031978	biolink:PhenotypicFeature	Increased vertical cup-to-disc ratio - 1.0	Ratio of the height of the cup of the optic nerve head to the height of the disc is 1.0 (The normal cup-to-disc ratio is 0.3).		hp.json		http://purl.obolibrary.org/obo/HP_0031978		
HP:0004302	biolink:PhenotypicFeature	Functional motor deficit		UMLS:C4025360	hp.json	Functional motor problems	http://purl.obolibrary.org/obo/HP_0004302		
HP:0031979	biolink:PhenotypicFeature	Abnormal urine carbohydrate level	Any deviation from the normal concentration of a carbohydrate in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031979		
UBERON:0004230	biolink:AnatomicalEntity	urinary bladder neck smooth muscle	A portion of smooth muscle tissue that is part of a neck of urinary bladder [Automatically generated definition].	EMAPA:30123|FMA:67990|MA:0001699	hp.json	trigonal muscle of urinary bladder|bladder neck smooth muscle tissue|smooth muscle tissue of neck of urinary bladder|smooth muscle of bladder neck|smooth muscle tissue of bladder neck|neck of bladder smooth muscle tissue|smooth muscle of neck of urinary bladder|non-striated muscle of vesical neck|non-striated muscle of urinary bladder neck|involuntary muscle of vesical neck|neck of urinary bladder smooth muscle|involuntary muscle of urinary bladder neck|neck of urinary bladder involuntary muscle|neck of bladder non-striated muscle|involuntary muscle of neck of urinary bladder|bladder neck non-striated muscle|non-striated muscle of neck of urinary bladder|smooth muscle of vesical neck|urinary bladder neck involuntary muscle|smooth muscle tissue of neck of bladder|smooth muscle of urinary bladder neck|smooth muscle tissue of vesical neck|smooth muscle tissue of urinary bladder neck|vesical neck involuntary muscle|smooth muscle of neck of bladder|neck of urinary bladder smooth muscle tissue|neck of bladder smooth muscle|bladder neck smooth muscle|urinary bladder neck muscle|vesical neck non-striated muscle|involuntary muscle of neck of bladder|urinary bladder neck smooth muscle tissue|trigonal muscle|vesical neck smooth muscle tissue|urinary bladder neck non-striated muscle|non-striated muscle of neck of bladder|non-striated muscle of bladder neck|bladder neck involuntary muscle|involuntary muscle of bladder neck|neck of bladder involuntary muscle|neck of urinary bladder non-striated muscle|vesical neck smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004230		
HP:0031973	biolink:PhenotypicFeature	Increased vertical cup-to-disc ratio	An abnormal increase in the ratio of the height of the cup of the optic nerve head to the height of the disc.		hp.json		http://purl.obolibrary.org/obo/HP_0031973		
HP:0006962	biolink:PhenotypicFeature	Gait instability, worse in the dark		UMLS:C1837016	hp.json	Unstable walking, worse in the dark	http://purl.obolibrary.org/obo/HP_0006962		
HP:0004307	biolink:PhenotypicFeature	Abnormal anatomic location of the heart	Developmental defect characterized by an anomalous anatomic location of the heart.	UMLS:C4025359	hp.json		http://purl.obolibrary.org/obo/HP_0004307		
HP:0004306	biolink:PhenotypicFeature	Abnormal endocardium morphology	An abnormality of the endocardium.	UMLS:C4021662	hp.json	Abnormality of the endocardium|Abnormality of the endomycoardium	http://purl.obolibrary.org/obo/HP_0004306		
HP:0031974	biolink:PhenotypicFeature	Increased vertical cup-to-disc ratio - 0.6	Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.6 (The normal cup-to-disc ratio is 0.3).		hp.json		http://purl.obolibrary.org/obo/HP_0031974		
HP:0004305	biolink:PhenotypicFeature	Involuntary movements	Involuntary contractions of muscle leading to involuntary movements of extremities, neck, trunk, or face.	UMLS:C0235086|SNOMEDCT_US:102542000	hp.json	Involuntary muscle contractions|Involuntary movements	http://purl.obolibrary.org/obo/HP_0004305		
HP:0031975	biolink:PhenotypicFeature	Increased vertical cup-to-disc ratio - 0.7	Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.7 (The normal cup-to-disc ratio is 0.3).		hp.json		http://purl.obolibrary.org/obo/HP_0031975		
HP:0006964	biolink:PhenotypicFeature	Cerebral cortical neurodegeneration		UMLS:C1859863	hp.json		http://purl.obolibrary.org/obo/HP_0006964		
HP:0031976	biolink:PhenotypicFeature	Increased vertical cup-to-disc ratio - 0.8	Ratio of the height of the cup of the optic nerve head to the height of the disc is 0.8 (The normal cup-to-disc ratio is 0.3).		hp.json		http://purl.obolibrary.org/obo/HP_0031976		
HP:0006965	biolink:PhenotypicFeature	Acute necrotizing encephalopathy		UMLS:C1855020	hp.json		http://purl.obolibrary.org/obo/HP_0006965		
UBERON:0004239	biolink:AnatomicalEntity	small intestine smooth muscle	A portion of smooth muscle tissue that is part of a small intestine [Automatically generated definition].	MA:0001559|EMAPA:35783	hp.json	smooth muscle tissue of small bowel|smooth muscle of small bowel|small bowel smooth muscle|small bowel smooth muscle tissue|involuntary muscle of small bowel|non-striated muscle of small bowel|small intestine non-striated muscle|small intestine involuntary muscle|smooth muscle tissue of small intestine|smooth muscle of small intestine|small intestine smooth muscle tissue|involuntary muscle of small intestine|non-striated muscle of small intestine|small bowel non-striated muscle|small bowel involuntary muscle	http://purl.obolibrary.org/obo/UBERON_0004239		pheno_slim
UBERON:0004237	biolink:AnatomicalEntity	blood vessel smooth muscle	Smooth muscle found within, and composing the majority of the wall of blood vessels.	Wikipedia:Vascular_smooth_muscle|ZFA:0005321|CALOHA:TS-1107|TAO:0005321|BTO:0001431|MA:0000710|EMAPA:35177|MESH:D009131|NCIT:C33853|UMLS:C1519956	hp.json	non-striated muscle of blood vessel|involuntary muscle of blood vessel|blood vessel involuntary muscle|smooth muscle of blood vessel|smooth muscle tissue of blood vessel|blood vessel smooth muscle tissue|blood vessel non-striated muscle|vascular smooth muscle tissue|vascular smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004237		pheno_slim
HP:0006960	biolink:PhenotypicFeature	Choroid plexus calcification	The presence of calcium deposition in the choroid plexus.	UMLS:C1863184	hp.json	Calcified choroid plexus	http://purl.obolibrary.org/obo/HP_0006960		
UBERON:0004238	biolink:AnatomicalEntity	spleen smooth muscle	A portion of smooth muscle tissue that is part of a spleen [Automatically generated definition].	MA:0000757|EMAPA:35807	hp.json	smooth muscle of spleen|smooth muscle tissue of spleen|spleen involuntary muscle|spleen non-striated muscle|spleen smooth muscle tissue|non-striated muscle of spleen|involuntary muscle of spleen	http://purl.obolibrary.org/obo/UBERON_0004238		
HP:0006961	biolink:PhenotypicFeature	Jerky head movements		UMLS:C1855568	hp.json	Jerking head movements|Head jerking	http://purl.obolibrary.org/obo/HP_0006961		
UBERON:0004235	biolink:AnatomicalEntity	mammary gland smooth muscle	A portion of smooth muscle tissue that is part of a mammary gland [Automatically generated definition].	MA:0000795|EMAPA:37669	hp.json	smooth muscle tissue of mammary gland	http://purl.obolibrary.org/obo/UBERON_0004235		
UBERON:0004236	biolink:AnatomicalEntity	arteriole smooth muscle	A portion of smooth muscle tissue that is part of an arteriole [Automatically generated definition].	FMA:312251|MA:0000706|EMAPA:36287	hp.json		http://purl.obolibrary.org/obo/UBERON_0004236		
UBERON:0004233	biolink:AnatomicalEntity	lower respiratory tract smooth muscle	A portion of smooth muscle tissue that is part of a lower respiratory tract [Automatically generated definition].	EMAPA:35520|MA:0002410	hp.json	lower respiratory tract involuntary muscle|lower respiratory tract non-striated muscle|smooth muscle tissue of lower respiratory tract|smooth muscle of lower respiratory tract|lower respiratory tract smooth muscle tissue|involuntary muscle of lower respiratory tract|non-striated muscle of lower respiratory tract	http://purl.obolibrary.org/obo/UBERON_0004233		
UBERON:0004234	biolink:AnatomicalEntity	iris smooth muscle	A portion of smooth muscle tissue that is part of a iris [Automatically generated definition].	BTO:0000655|EMAPA:35448|MA:0001270|FMA:312338	hp.json	iris non-striated muscle|iridial smooth muscle|iridial smooth muscle|iris involuntary muscle|non-striated muscle of iris|involuntary muscle of iris|iris smooth muscle tissue|smooth muscle of iris|smooth muscle tissue of iris	http://purl.obolibrary.org/obo/UBERON_0004234		
NBO:0000417	biolink:NamedThing	physiologic nystagmus	"A form of involuntary eye movement that is part of the vestibulo-ocular reflex (VOR). It is characterized by alternating smooth pursuit in one direction and saccadic movement in the other direction." [wikipedia:Physiologic_nystagmus]		hp.json		http://purl.obolibrary.org/obo/NBO_0000417		
NBO:0000416	biolink:NamedThing	vestibulo-ocular reflex	"A reflex eye movement that stabilizes images on the retina during head movement by producing an eye movement in the direction opposite to head movement, thus preserving the image on the center of the visual field." [wikipedia:Vestibulo-ocular_reflex]		hp.json	VOR|oculovestibular reflex|vestibuloocular reflex	http://purl.obolibrary.org/obo/NBO_0000416		
NBO:0000411	biolink:NamedThing	cranial nerve related reflex	"A reflex that involves cranial nerves." [wikipedia:Reflex]		hp.json		http://purl.obolibrary.org/obo/NBO_0000411		
GO:0140546	biolink:BiologicalProcess	defense response to symbiont	Reactions triggered in response to the presence of a symbiont that act to protect the cell or organism from damage caused by that symbiont.		hp.json		http://purl.obolibrary.org/obo/GO_0140546		
NBO:0000419	biolink:NamedThing	sleeping behavior phenotype	"Observable characteristic of behavior related to the readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000419		
HP:0031900	biolink:PhenotypicFeature	obsolete Abnormal serum tryptase concentration			hp.json		http://purl.obolibrary.org/obo/HP_0031900		
HP:0004358	biolink:PhenotypicFeature	Abnormality of superoxide metabolism		UMLS:C4025340	hp.json		http://purl.obolibrary.org/obo/HP_0004358		
HP:0004357	biolink:PhenotypicFeature	Abnormal circulating leucine concentration	Any deviation from the normal circulation of leucine in the blood circulation.	UMLS:C4025341	hp.json		http://purl.obolibrary.org/obo/HP_0004357		
HP:0031901	biolink:PhenotypicFeature	Elevated total serum tryptase	An abnormally elevated concentration of total tryptase (alpha and beta tryptase) in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031901		
HP:0004356	biolink:PhenotypicFeature	Abnormality of lysosomal metabolism		UMLS:C4025342	hp.json		http://purl.obolibrary.org/obo/HP_0004356		
HP:0031902	biolink:PhenotypicFeature	obsolete Decreased serum mast cell beta-tryptase concentration			hp.json		http://purl.obolibrary.org/obo/HP_0031902		
HP:0031903	biolink:PhenotypicFeature	Abnormal circulating selenium concentration	Any deviation from the normal circulating concentration of selenium.		hp.json	Abnormal serum selenium concentration	http://purl.obolibrary.org/obo/HP_0031903		
HP:0004355	biolink:PhenotypicFeature	obsolete Abnormality of proteoglycan metabolism			hp.json		http://purl.obolibrary.org/obo/HP_0004355		
HP:0004359	biolink:PhenotypicFeature	Abnormal circulating fatty-acid concentration	A deviation from the normal concentration of a fatty acid in the blood circulation.	UMLS:C4021656|UMLS:C4020830	hp.json	Abnormality of fatty acid metabolism|Fatty acids abnormal	http://purl.obolibrary.org/obo/HP_0004359		
HP:0031908	biolink:PhenotypicFeature	Micrographia	Abnormally small sized handwriting defined formally as an impairment of a fine motor skill manifesting mainly as a progressive or stable reduction in amplitude during a writing task.		hp.json		http://purl.obolibrary.org/obo/HP_0031908		
HP:0031909	biolink:PhenotypicFeature	Unicornuate uterus	A uterus that has a single horn, with a banana-like shape that may or may not have a secondary rudimentary uterine horn.		hp.json		http://purl.obolibrary.org/obo/HP_0031909		
NBO:0000420	biolink:NamedThing	bruxism	"A NREM parasomnia characterised by Involuntarily grinding of teeth while sleeping." [MBP:GVG]		hp.json	teeth grinding|<new synonym>	http://purl.obolibrary.org/obo/NBO_0000420		
HP:0031904	biolink:PhenotypicFeature	Abnormal total hemolytic complement activity	Any deviation from the normal total hemolytic complement activity in the circulation.		hp.json	Abnormal CH50	http://purl.obolibrary.org/obo/HP_0031904		
HP:0004354	biolink:PhenotypicFeature	Abnormal circulating carboxylic acid concentration	Any deviation from the normal concentration of a carboxylic acid in the blood circulation.	UMLS:C4025344	hp.json		http://purl.obolibrary.org/obo/HP_0004354		
HP:0004353	biolink:PhenotypicFeature	Abnormal circulating pyrimidine concentration	Any deviation from the normal concentration of a pyrimidine in the blood circulation.	UMLS:C4025345	hp.json		http://purl.obolibrary.org/obo/HP_0004353		
HP:0031905	biolink:PhenotypicFeature	Increased total hemolytic complement activity	An abnormally elevated total hemolytic complement activity in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031905		
HP:0031906	biolink:PhenotypicFeature	Decreased total hemolytic complement activity	An abnormally reduced total hemolytic complement activity in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031906		
HP:0004352	biolink:PhenotypicFeature	Abnormal circulating purine concentration	Any deviation from the normal concentration of a purine in the blood circulation.	UMLS:C4025346	hp.json	Abnormal circulating purine level	http://purl.obolibrary.org/obo/HP_0004352		
HP:0031907	biolink:PhenotypicFeature	Anti-mitochondrial M2 antibody positivity	The presence of M2 anti-mitochondrial antibody (immunoglobulins) in the serum.		hp.json	Anti-pyruvate dehydrogenase antibody positivity|AMA-M2 positive	http://purl.obolibrary.org/obo/HP_0031907		
UBERON:0004290	biolink:AnatomicalEntity	dermomyotome	The bilaminar epithelium formed from the myotome and dermatome.	EMAPA:31109|EHDAA2:0003259|FMA:295654|AAO:0010572|AEO:0000214|VHOG:0000676|NCIT:C34140|UMLS:C1511786|ZFA:0001513|TAO:0001513	hp.json	dermamyotome|dermomyotomes	http://purl.obolibrary.org/obo/UBERON_0004290		
HP:0004369	biolink:PhenotypicFeature	Decreased circulating purine concentration	Abnormally reduced concentration of a purine compound. Purine compounds are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring.	UMLS:C4025331	hp.json	Decreased purine levels|Decreased purine level	http://purl.obolibrary.org/obo/HP_0004369		
HP:0031911	biolink:PhenotypicFeature	Abnormal fifth cranial nerve physiology			hp.json		http://purl.obolibrary.org/obo/HP_0031911		
UBERON:0004297	biolink:AnatomicalEntity	respiratory system blood vessel smooth muscle	A blood vessel smooth muscle that is part of a respiratory system [Automatically generated definition].	MA:0001806|EMAPA:37573	hp.json	smooth muscle tissue of blood vessel of respiratory system	http://purl.obolibrary.org/obo/UBERON_0004297		
HP:0031912	biolink:PhenotypicFeature	Trigeminal anesthesia	Decreased or absent sensation in the distribution of the trigeminal nerve, which provides tactile, proprioceptive, and nociceptive sensation in the area of the face and mouth.		hp.json	Trigeminal anaesthesia	http://purl.obolibrary.org/obo/HP_0031912		
HP:0004368	biolink:PhenotypicFeature	Increased circulating purine concentration	Abnormally elevated concentration of a purine compound. Purine compounds are aromatic heterocyclic compounds containing a purine moiety, which is formed a pyrimidine-ring ring fused to an imidazole ring.	UMLS:C4025332	hp.json	Increased purine level|Increased purine levels	http://purl.obolibrary.org/obo/HP_0004368		
UBERON:0004295	biolink:AnatomicalEntity	sympathetic nerve trunk	A nerve trunk that is part of a sympathetic nervous system [Automatically generated definition].	EHDAA2:0001970|EMAPA:35845|MA:0000227	hp.json	nerve trunk of sympathetic nervous system|nerve trunk of sympathetic part of autonomic division of nervous system|sympathetic nervous system nerve trunk	http://purl.obolibrary.org/obo/UBERON_0004295		pheno_slim
HP:0031913	biolink:PhenotypicFeature	Rhombencephalosynapsis	Rhombencephalosynapsis is a rare brain malformation defined by midline fusion of the cerebellar hemispheres with partial or complete loss of the intervening vermis.		hp.json		http://purl.obolibrary.org/obo/HP_0031913		
HP:0004367	biolink:PhenotypicFeature	obsolete Abnormality of glycoprotein metabolism			hp.json		http://purl.obolibrary.org/obo/HP_0004367		
UBERON:0004296	biolink:AnatomicalEntity	respiratory system lymphatic vessel smooth muscle	A lymphatic vessel smooth muscle that is part of a respiratory system [Automatically generated definition].	MA:0001826|EMAPA:37582	hp.json	smooth muscle of lymph vessel of respiratory system	http://purl.obolibrary.org/obo/UBERON_0004296		human_reference_atlas
HP:0031914	biolink:PhenotypicFeature	Fluctuating	Varying irregularly over time in severity, amount, or amplitude.		hp.json		http://purl.obolibrary.org/obo/HP_0031914		
HP:0004366	biolink:PhenotypicFeature	Abnormality of glycolysis	An abnormality of glycolysis.	UMLS:C4025334	hp.json		http://purl.obolibrary.org/obo/HP_0004366		
UBERON:0004293	biolink:AnatomicalEntity	parasympathetic nerve	A nerve that is part of a parasympathetic nervous system [Automatically generated definition].	MA:0000224|EHDAA2:0001401|EMAPA:17271|SCTID:276146002|VHOG:0000641	hp.json	nerve of parasympathetic nervous system	http://purl.obolibrary.org/obo/UBERON_0004293		
UBERON:0004294	biolink:AnatomicalEntity	glomerular capillary endothelium	An endothelium that is part of a glomerular capillary.	NCIT:C32522|UMLS:C0227647|MA:0001658	hp.json	renal glomerulus capillary endothelium	http://purl.obolibrary.org/obo/UBERON_0004294		pheno_slim|human_reference_atlas
UBERON:0004291	biolink:AnatomicalEntity	heart rudiment	A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.	TAO:0000115|ZFA:0000115	hp.json	rudimentary heart|heart cone	http://purl.obolibrary.org/obo/UBERON_0004291		
UBERON:0004292	biolink:AnatomicalEntity	cardiac skeleton	Dense connective tissue that separates the atria from the ventricles and provides physical support for the heart.	FMA:9496|Wikipedia:Cardiac_skeleton|EMAPA:36645	hp.json	trigona fibrosa|trigonum fibrosum dextrum cordis|anulus fibrosus dexter cordis|heart fibrous skeleton|trigona fibrosa|trigonum fibrosum dextrum cordis|anulus fibrosus sinister cordis|skeleton of heart|fibrous skeleton of heart|anulus fibrosus sinister cordis|cardiac fibrous skeleton|trigonum fibrosum sinistrum cordis|trigonum fibrosum sinistrum cordis|anulus fibrosus dexter cordis	http://purl.obolibrary.org/obo/UBERON_0004292		
HP:0031910	biolink:PhenotypicFeature	Abnormal cranial nerve physiology	A functional abnormality affecting one or more of the cranial nerves, which emerge directly from the brain stem.		hp.json		http://purl.obolibrary.org/obo/HP_0031910		
HP:0004361	biolink:PhenotypicFeature	Abnormality of circulating leptin level	An abnormal concentration of leptin in the blood.	UMLS:C4025339	hp.json		http://purl.obolibrary.org/obo/HP_0004361		
HP:0031919	biolink:PhenotypicFeature	Juvenile type ovarian granulosa cell tumor	Juvenile granulosa cell ovarian tumor (JGCOT) is a rare sex cord stromal tumor, occuring most frequently in premenarchal girls or young women. In contrast to adult granulosa cell tumor, JGCOT has a high mitotic index and more aggressive tumor growth. Microscopically it is seen as diffuse and regularly distributed neoplastic cells with a wide cytoplasm and pleomorphic hyperchromatic nucleus. Follicle formation, in various sizes and shapes, is important in JGCOT. Call-Exner bodies are infrequently seen in JGCOT in contrast to the adult type.		hp.json	Ovarian juvenile granulosa cell tumour|Juvenile type ovarian granulosa cell tumour|Ovarian juvenile granulosa cell tumor	http://purl.obolibrary.org/obo/HP_0031919		
HP:0004360	biolink:PhenotypicFeature	Abnormality of acid-base homeostasis	An abnormality of the balance or maintenance of the balance of acids and bases in bodily fluids, resulting in an abnormal pH.	MSH:D000137|UMLS:C0001118	hp.json	Acid base imbalance	http://purl.obolibrary.org/obo/HP_0004360		
HP:0004365	biolink:PhenotypicFeature	Abnormal circulating tryptophan concentration	Any deviation from the normal concentration of tryptophan in the blood circulation.	UMLS:C4025335	hp.json	Abnormality of tryptophan metabolism	http://purl.obolibrary.org/obo/HP_0004365		
HP:0031915	biolink:PhenotypicFeature	Stable	This modifier can be applied to a phenotypic feature that does not vary in severity or amount over time.		hp.json		http://purl.obolibrary.org/obo/HP_0031915		
HP:0004364	biolink:PhenotypicFeature	Abnormal circulating nitrogen compound concentration	Any deviation from the normal concentration of a nitrogen compound in the blood circulation.	UMLS:C4025336	hp.json		http://purl.obolibrary.org/obo/HP_0004364		
HP:0031917	biolink:PhenotypicFeature	Digital ulcer	An open sore on the surface of the skin of a finger or toe.		hp.json		http://purl.obolibrary.org/obo/HP_0031917		
HP:0004363	biolink:PhenotypicFeature	Abnormal circulating calcium concentration	Any deviation from the normal concentration of calcium in the blood circulation.		hp.json	Abnormal circulating Ca2+ concentration|Abnormal blood calcium levels|Abnormal circulating Ca concentration|Abnormal blood calcium concentration	http://purl.obolibrary.org/obo/HP_0004363		
HP:0031918	biolink:PhenotypicFeature	Ovarian sex cord-stromal tumor	A benign or malignant neoplasm that arises from the ovary and is composed of granulosa cells, Sertoli cells, Leydig cells, theca cells, and fibroblasts.		hp.json	Ovarian sex cord-stromal tumour	http://purl.obolibrary.org/obo/HP_0031918		
HP:0004362	biolink:PhenotypicFeature	Abnormality of enteric ganglion morphology	An abnormality of the enteric nervous system, which comprises two types of ganglia, the myenteric (Auerbach's) and submucosal (Meissner's) plexuses. The enteric nervous system functions to control gut movement, fluid exchange between the gut and its lumen, and local blood flow.	UMLS:C4025338	hp.json	Abnormality of the enteric ganglia	http://purl.obolibrary.org/obo/HP_0004362		
HP:0031922	biolink:PhenotypicFeature	Renal artery duplication	The renal arteries carry blood from the aorta to the kidney; normally one renal artery is present on each side of the body. Renal artery duplication refers to the presence of two rather than one renal artery on a given side of the body.		hp.json	Double renal artery|Accessory renal artery	http://purl.obolibrary.org/obo/HP_0031922		
HP:0004336	biolink:PhenotypicFeature	Myelin outfoldings	The presence of excessive redundant myelin in the peripheral nerve sheath.	UMLS:C1843168	hp.json	Irregular myelin foldings|Excessive focal folding of myelin sheaths	http://purl.obolibrary.org/obo/HP_0004336		
HP:0006999	biolink:PhenotypicFeature	Basal ganglia gliosis	Focal proliferation of glial cells in the basal ganglia.	UMLS:C1864114|UMLS:C2750915	hp.json	Gliosis in the basal ganglia	http://purl.obolibrary.org/obo/HP_0006999		
HP:0031923	biolink:PhenotypicFeature	Hematocolpos	Accumulation of blood in the vagina usually due to vaginal obstruction.		hp.json	Haematocolpos	http://purl.obolibrary.org/obo/HP_0031923		
HP:0004334	biolink:PhenotypicFeature	Dermal atrophy	Partial or complete wasting (atrophy) of the skin.	MEDDRA:10040799|SNOMEDCT_US:400190005|SNOMEDCT_US:399979006|UMLS:C0151514	hp.json	Skin atrophy|Atrophic skin|Skin degeneration	http://purl.obolibrary.org/obo/HP_0004334		hposlim_core
HP:0031924	biolink:PhenotypicFeature	Rope sign	The presence of linear erythematous palpable cords, often on the lateral trunk.		hp.json		http://purl.obolibrary.org/obo/HP_0031924		
HP:0031925	biolink:PhenotypicFeature	Rosette	A halo or spoke-wheel arrangement of cells surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core; the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub.		hp.json		http://purl.obolibrary.org/obo/HP_0031925		
HP:0004333	biolink:PhenotypicFeature	Bone-marrow foam cells	The presence of foam cells in the bone marrow, generally demonstrated by bone-marrow aspiration or biopsy. Foam cells have a vacuolated appearance due to the presence of complex lipid deposits, giving them a foamy or soap-suds appearance.	UMLS:C1856560	hp.json	Large vacuolated foam cells on bone marrow biopsy|Large vacuolated foam cells ('NP cells') on bone marrow biopsy|Bone marrow foam cells	http://purl.obolibrary.org/obo/HP_0004333		
HP:0004339	biolink:PhenotypicFeature	Abnormal circulating sulfur amino acid concentration	Any deviation from the normal concentration of a sulfur amino acid in the blood circulation.	UMLS:C4021660	hp.json	Abnormality of sulfur-containing amino acids|Abnormal circulating sulphur amino acid concentration	http://purl.obolibrary.org/obo/HP_0004339		
HP:0031920	biolink:PhenotypicFeature	Malignant ovarian granulosa cell tumor	An aggressive granulosa cell tumor that arises from the ovary.		hp.json	Malignant ovarian granulosa cell tumour	http://purl.obolibrary.org/obo/HP_0031920		
HP:0004338	biolink:PhenotypicFeature	Abnormal circulating aromatic amino acid concentration	Any deviation from the normal concentration of a aromatic amino acid in the blood circulation.	UMLS:C4025352	hp.json	Abnormality of aromatic amino acid family metabolism	http://purl.obolibrary.org/obo/HP_0004338		
HP:0004337	biolink:PhenotypicFeature	Abnormality of amino acid metabolism	Abnormality of an amino acid metabolic process.	UMLS:C1328440	hp.json	Amino acid levels abnormal	http://purl.obolibrary.org/obo/HP_0004337		
HP:0031921	biolink:PhenotypicFeature	Gastrocnemius myalgia	Pain of the gastrocnemius muscle.		hp.json	Calf muscle pain|Calf myalgia	http://purl.obolibrary.org/obo/HP_0031921		
HP:0006992	biolink:PhenotypicFeature	Anterior basal encephalocele		UMLS:C1850961	hp.json		http://purl.obolibrary.org/obo/HP_0006992		
HP:0006994	biolink:PhenotypicFeature	Diffuse leukoencephalopathy		UMLS:C1868514	hp.json		http://purl.obolibrary.org/obo/HP_0006994		
HP:0004332	biolink:PhenotypicFeature	Abnormal lymphocyte morphology	An abnormality of lymphocytes.	UMLS:C0427546|SNOMEDCT_US:250284007	hp.json	Abnormal lymphocytes|Abnormality of cells of the lymphoid lineage	http://purl.obolibrary.org/obo/HP_0004332		
HP:0031926	biolink:PhenotypicFeature	Homer Wright rosette	A type of rosette in which the central lumen or hub is filled with fiber-like processes.		hp.json		http://purl.obolibrary.org/obo/HP_0031926		
HP:0004331	biolink:PhenotypicFeature	Decreased skull ossification	A reduction in the magnitude or amount of ossification of the skull.	UMLS:C4280533|SNOMEDCT_US:253980008|UMLS:C0432073	hp.json	Ossification defect of skull|Poorly ossified skull bones|Decreased calcification of skull|Poorly mineralized skull|Poorly ossified skull|Decreased mineralization of skull|Deficient skull ossification|Decreased bone formation of skull|Hypoossification of skull	http://purl.obolibrary.org/obo/HP_0004331		hposlim_core
HP:0031927	biolink:PhenotypicFeature	Flexner-Wintersteiner rosette	The tumor cells that form the Flexner-Wintersteiner rosette circumscribe a central lumen that contains small cytoplasmic extensions of the encircling cells; however, unlike the center of the Homer Wright rosette, the central lumen does not contain the fiber-rich neuropil.		hp.json		http://purl.obolibrary.org/obo/HP_0031927		
HP:0004330	biolink:PhenotypicFeature	Increased skull ossification	An increase in the magnitude or amount of ossification of the skull.	UMLS:C0020496|UMLS:C4072851|UMLS:C4072850|SNOMEDCT_US:17401000119104	hp.json	Increased calcification of skull|Hyperostosis of skull|Sclerosis of skull|Hyperossification of skull|Sclerosis of bones of skull|Increased Mineralization of skull	http://purl.obolibrary.org/obo/HP_0004330		hposlim_core
UBERON:0004288	biolink:AnatomicalEntity	skeleton	Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body.	MIAA:0000032|Wikipedia:Skeleton|EMAPA:17213|EHDAA2:0001843|MA:0003006|GAID:177|galen:Skeleton|MESH:D012863|OpenCyc:Mx4rvVi1rpwpEbGdrcN5Y29ycA|EHDAA:5047|XAO:0004053|MAT:0000032|FMA:23875|VSAO:0000026|AEO:0000168|SCTID:361378004	hp.json	set of bones of body|set of all bones	http://purl.obolibrary.org/obo/UBERON_0004288		uberon_slim|pheno_slim|efo_slim
HP:0031928	biolink:PhenotypicFeature	True ependymal rosette	A type of rosette in which a halo of cells surrounds an empty lumen.		hp.json		http://purl.obolibrary.org/obo/HP_0031928		
HP:0006990	biolink:PhenotypicFeature	Myelin-dependent gliosis	A type of gliosis that occurs in the vicinity of injured neurons.	UMLS:C4024954	hp.json		http://purl.obolibrary.org/obo/HP_0006990		
HP:0031929	biolink:PhenotypicFeature	Perivascular pseudorosette	A type of rosette in which a spoke-wheel arrangement of cells with tapered cellular processes radiates around a wall of a centrally placed vessel.		hp.json		http://purl.obolibrary.org/obo/HP_0031929		
NBO:0000403	biolink:NamedThing	voluntary movement behavior	"Behavior related to movements executed with intent." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000403		
UBERON:0004275	biolink:AnatomicalEntity	third ventricle choroid plexus epithelium	A choroid plexus epithelium that is part of a third ventricle [Automatically generated definition].	EMAPA:37055|MA:0000880|FMA:242821	hp.json	third ventricle epithelium of chorioid plexus of cerebral hemisphere|third ventricle epithelial tissue of chorioid plexus of cerebral hemisphere|epithelium of choroid plexus of third ventricle|epithelial tissue of chorioid plexus of cerebral hemisphere of third ventricle|choroid plexus epithelium of third ventricle|epithelial tissue of choroid plexus of third ventricle|chorioid plexus of cerebral hemisphere epithelium of third ventricle|third ventricle choroid plexus epithelial tissue|third ventricle chorioid plexus of cerebral hemisphere epithelial tissue|chorioid plexus of cerebral hemisphere epithelial tissue of third ventricle|choroid plexus epithelial tissue of third ventricle|third ventricle chorioid plexus of cerebral hemisphere epithelium|third ventricle epithelium of choroid plexus|third ventricle epithelial tissue of choroid plexus|epithelium of chorioid plexus of cerebral hemisphere of third ventricle	http://purl.obolibrary.org/obo/UBERON_0004275		
HP:0004347	biolink:PhenotypicFeature	Weakness of muscles of respiration	Reduced function of the muscles required to generate subatmospheric pressure in the thoracic cavity during breathing: the diaphragm, the external intercostal and the interchondral part of the internal intercostal muscles.	UMLS:C4025347	hp.json		http://purl.obolibrary.org/obo/HP_0004347		
HP:0031933	biolink:PhenotypicFeature	Aorto-right ventricular tunnel	The presence of an extracardiac channel that connects the ascending aorta above the sinotubular junction to the cavity of the right ventricle.		hp.json	Right ventricle to aorta tunnel	http://purl.obolibrary.org/obo/HP_0031933		
UBERON:0004276	biolink:AnatomicalEntity	fourth ventricle choroid plexus epithelium	A choroid plexus epithelium that is part of a fourth ventricle [Automatically generated definition].	NCIT:C49230|MA:0000984|UMLS:C1707392|FMA:242823	hp.json	fourth ventricle epithelium of choroid plexus|chorioid plexus of cerebral hemisphere epithelium of fourth ventricle|epithelial tissue of choroid plexus of fourth ventricle|fourth ventricle epithelium of chorioid plexus of cerebral hemisphere|choroid plexus epithelium of fourth ventricle|epithelium of choroid plexus of fourth ventricle|epithelial tissue of chorioid plexus of cerebral hemisphere of fourth ventricle|epithelium of chorioid plexus of cerebral hemisphere of fourth ventricle|fourth ventricle choroid plexus epithelial tissue|fourth ventricle chorioid plexus of cerebral hemisphere epithelium|fourth ventricle chorioid plexus of cerebral hemisphere epithelial tissue|fourth ventricle epithelial tissue of choroid plexus|choroid plexus epithelial tissue of fourth ventricle|fourth ventricle epithelial tissue of chorioid plexus of cerebral hemisphere|chorioid plexus of cerebral hemisphere epithelial tissue of fourth ventricle	http://purl.obolibrary.org/obo/UBERON_0004276		
HP:0031934	biolink:PhenotypicFeature	Abnormal descending aorta morphology	A structural abnormality of the part of the aorta that begins at the aortic arch and then descends through the chest and abdomen.		hp.json		http://purl.obolibrary.org/obo/HP_0031934		
HP:0004345	biolink:PhenotypicFeature	Ganglioside accumulation	Defects in the lysosomal glycosidases or specific co-activators, result in accumulation of the substrates, such as glycosphingolipids, including gangliosides in GM1 gangliosidosis (Tay-Sachs disease) and GM2 gangliosidosis (Sandhoff disease).	UMLS:C4025348	hp.json		http://purl.obolibrary.org/obo/HP_0004345		
UBERON:0004273	biolink:AnatomicalEntity	cartilaginous joint suture	A cranial suture that is part of a cartilaginous joint [Automatically generated definition].	MA:0001498|EMAPA:37463	hp.json	articulatio cartilaginea cranial sutures|cranial suture of cartilaginous joint|articulatio cartilaginea cranial suture|cartilaginous joint cranial sutures set|cranium suture of cartilaginous joint|cartilaginous joint suture of cranium|cartilaginous joint cranial sutures|cranial sutures set of articulatio cartilaginea|suture of cranium of articulatio cartilaginea|cranial sutures of cartilaginous joint|cranial sutures of articulatio cartilaginea|suture of cranium of cartilaginous joint|cranial sutures set of cartilaginous joint|cartilaginous joint cranium suture|cranium suture of articulatio cartilaginea|cartilaginous joint cranial suture|articulatio cartilaginea cranial sutures set|cranial suture of articulatio cartilaginea|articulatio cartilaginea cranium suture|articulatio cartilaginea suture of cranium	http://purl.obolibrary.org/obo/UBERON_0004273		
HP:0031935	biolink:PhenotypicFeature	Ascending aorta hypoplasia	Significant luminal narrowing of a long segment of or the entire ascending aorta.		hp.json		http://purl.obolibrary.org/obo/HP_0031935		
UBERON:0004274	biolink:AnatomicalEntity	lateral ventricle choroid plexus epithelium	A choroid plexus epithelium that is part of a lateral ventricle [Automatically generated definition].	EHDAA2:0004450|MA:0000962|UMLS:C1711323|FMA:242815|NCIT:C49248	hp.json	lateral ventricle epithelial tissue of chorioid plexus of cerebral hemisphere|lateral ventricle epithelium of chorioid plexus of cerebral hemisphere|epithelium of choroid plexus of lateral ventricle|epithelial tissue of chorioid plexus of cerebral hemisphere of lateral ventricle|choroid plexus epithelium of lateral ventricle|epithelial tissue of choroid plexus of lateral ventricle|chorioid plexus of cerebral hemisphere epithelium of lateral ventricle|lateral ventricle choroid plexus epithelial tissue|lateral ventricle chorioid plexus of cerebral hemisphere epithelial tissue|chorioid plexus of cerebral hemisphere epithelial tissue of lateral ventricle|choroid plexus epithelial tissue of lateral ventricle|lateral ventricle chorioid plexus of cerebral hemisphere epithelium|lateral ventricle epithelial tissue of choroid plexus|lateral ventricle epithelium of choroid plexus|epithelium of chorioid plexus of cerebral hemisphere of lateral ventricle	http://purl.obolibrary.org/obo/UBERON_0004274		
HP:0031936	biolink:PhenotypicFeature	Delayed ability to walk	A failure to achieve the ability to walk at an appropriate developmental stage. Most children learn to walk in a series of stages, and learn to walk short distances independently between 12 and 15 months.		hp.json	Delayed walking	http://purl.obolibrary.org/obo/HP_0031936		
HP:0004344	biolink:PhenotypicFeature	Abnormality of cerebrosidase metabolism		UMLS:C4025349	hp.json		http://purl.obolibrary.org/obo/HP_0004344		
UBERON:0004271	biolink:AnatomicalEntity	outflow tract pericardium	A pericardium that is part of a outflow tract [Automatically generated definition].	EMAPA:37707|MA:0000491	hp.json	pericardium of outflow tract	http://purl.obolibrary.org/obo/UBERON_0004271		
HP:0031930	biolink:PhenotypicFeature	Neurocytic rosette	A type of rosette that is similar to the Homer Wright rosette, but the central fiber-rich neuropil island is larger and more irregular.		hp.json	Pineocytomatous rosette	http://purl.obolibrary.org/obo/HP_0031930		
HP:0004349	biolink:PhenotypicFeature	Reduced bone mineral density	A reduction of bone mineral density, that is, of the amount of matter per cubic centimeter of bones.	UMLS:C2674432	hp.json	Low solidness and mass of the bones|Decreased bone mineral density Z score|Decreased bone mineral density	http://purl.obolibrary.org/obo/HP_0004349		
HP:0031931	biolink:PhenotypicFeature	Ocular flutter	Ocular flutter is an abnormal eye movement consisting of repetitive, irregular, involuntary bursts of horizontal saccades without an intersaccadic interval. It is generally superimposed on normal oculomotor behaviour and its occurrence may be favoured by various events, such as blinks, the triggering of normal saccades or optokinetic stimulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031931		
UBERON:0004270	biolink:AnatomicalEntity	lower leg connective tissue	A portion of connective tissue that is part of a lower leg [Automatically generated definition].	MA:0000677|EMAPA:37327	hp.json		http://purl.obolibrary.org/obo/UBERON_0004270		
HP:0004348	biolink:PhenotypicFeature	Abnormality of bone mineral density	This term applies to all changes in bone mineral density which (depending on severity) can be seen on x-rays as a change in density and or structure of the bone. Changes may affect all bones of the organism, just certain bones or only parts of bones and include decreased mineralisation as may be seen in osteoporosis or increased mineralisation and or ossification as in osteopetrosis, exostoses or any kind of atopic calicfications of different origin and distribution. The overall amount of mineralization of the bone-organ can be measured as the amount of matter per cubic centimeter of bones, usually measured by densitometry of the lumbar spine or hip. The measurements are usually reported as g/cm3 or as a Z-score (the number of standard deviations above or below the mean for the patient's age and sex). Note that measurement with this method does not reflect local changes in other bones, and as such might not be correct with regard the hole bone-organ.	UMLS:C4021657	hp.json	Abnormality of bone mineralisation and ossification	http://purl.obolibrary.org/obo/HP_0004348		
HP:0031932	biolink:PhenotypicFeature	Aorto-left ventricular tunnel	Aorto-left ventricular tunnel (ALVT) is a congenital extracardiac channel connecting the ascending aorta above the sino-tubular junction to either left ventricular cavity.		hp.json	Left ventricle to aorta tunnel	http://purl.obolibrary.org/obo/HP_0031932		
HP:0031937	biolink:PhenotypicFeature	Tachylalia	Extreme rapidity of speech.		hp.json	Tachylogia	http://purl.obolibrary.org/obo/HP_0031937		
HP:0004343	biolink:PhenotypicFeature	Abnormal glycosphingolipid metabolism	An abnormality of glycosphingolipid metabolism.	UMLS:C4025350	hp.json	Abnormality of glycosphingolipid metabolism	http://purl.obolibrary.org/obo/HP_0004343		
HP:0031938	biolink:PhenotypicFeature	Abnormal conus terminalis morphology	Any structural anomaly of the conus terminalis, which is the distal bulbous part of the spinal cord at the location where the spinal cord tapers and ends (usually between the L1 and L2 lumbar vertebrae).		hp.json	Abnormal conus medullaris morphology	http://purl.obolibrary.org/obo/HP_0031938		
HP:0004342	biolink:PhenotypicFeature	Abnormality of galactoside metabolism	Abnormality of galactoside metabolism. A galactoside is a glycoside (a suger moiety bound to some other moiety) containing galactose.	UMLS:C4025351	hp.json		http://purl.obolibrary.org/obo/HP_0004342		
UBERON:0004277	biolink:AnatomicalEntity	eye muscle	A muscle that is part of the eye region.	EMAPA:35335|OpenCyc:Mx8Ngx4rwKSh9pwpEbGdrcN5Y29ycB4rvViTvpwpEbGdrcN5Y29ycB4rvYA8cJwpEbGdrcN5Y29ycA|AAO:0000156|MA:0000271	hp.json		http://purl.obolibrary.org/obo/UBERON_0004277		pheno_slim
HP:0031939	biolink:PhenotypicFeature	Conus terminalis arteriovenous malformation			hp.json		http://purl.obolibrary.org/obo/HP_0031939		
HP:0004341	biolink:PhenotypicFeature	Abnormality of vitamin B12 metabolism		UMLS:C4021658	hp.json	Abnormality of the vitamin B12 metabolism	http://purl.obolibrary.org/obo/HP_0004341		
HP:0004340	biolink:PhenotypicFeature	Abnormality of vitamin B metabolism		UMLS:C4021659	hp.json	Abnormality of B-vitamin metabolism	http://purl.obolibrary.org/obo/HP_0004340		
UBERON:0006839	biolink:AnatomicalEntity	dorsal ramus of spinal nerve	Branch of spinal nerve that innervates the epaxial muscles.	FMA:5983	hp.json	ramus posterior|ramus posterior nervi spinalis|posterior branch of spinal nerve|posterior primary ramus|posterior ramus of spinal nerve|dorsal ramus	http://purl.obolibrary.org/obo/UBERON_0006839		
UBERON:0006838	biolink:AnatomicalEntity	ventral ramus of spinal nerve	Branch of spinal nerve that innervates the hypaxial muscles.	FMA:5982	hp.json	ramus anterior|ramus anterior nervi spinalis|anterior branch of spinal nerve|anterior primary ramus of spinal nerve|ventral ramus|anterior ramus of spinal nerve|ventral ramus of spinal nerve	http://purl.obolibrary.org/obo/UBERON_0006838		
GO:0007631	biolink:BiologicalProcess	feeding behavior	Behavior associated with the intake of food.	Wikipedia:List_of_feeding_behaviours	hp.json	feeding from xylem of other organism|feeding from plant phloem|behavioral response to food|injection of substance into other organism during feeding on blood of other organism|feeding on blood of other organism|feeding on or from other organism|feeding from vascular tissue of another organism|hematophagy|feeding behaviour|feeding from tissue of other organism|eating|feeding from phloem of other organism|feeding on plant sap|behavioural response to food|taking of blood meal	http://purl.obolibrary.org/obo/GO_0007631		
CHEBI:3424	biolink:ChemicalSubstance	carnitinium	A quaternary ammonium ion that is the the conjugate acid of carnitine.	CAS:406-76-8|KEGG:C00487|CAS:461-06-3	hp.json	Carnitine|3-hydroxy-4-(trimethylammonio)butanoic acid|3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium	http://purl.obolibrary.org/obo/CHEBI_3424		3_STAR
UBERON:0006847	biolink:AnatomicalEntity	cerebellar commissure	A nervous system commissure that connects a left hemisphere of cerebellum and connects a right hemisphere of cerebellum.	TAO:0000490|BAMS:cbc|DMBA:17754|MBA:744|ZFA:0000490|FMA:77522	hp.json	commissure of cerebellum|commissura cerebelli	http://purl.obolibrary.org/obo/UBERON_0006847		vertebrate_core
UBERON:0006846	biolink:AnatomicalEntity	surface groove	A furrow or an incomplete tube.	AEO:0000161|EHDAA2_RETIRED:0003161	hp.json	groove	http://purl.obolibrary.org/obo/UBERON_0006846		grouping_class
UBERON:0006844	biolink:AnatomicalEntity	cusp of tooth	A raised area of the biting surface of a tooth.	FMA:56481|UMLS:C0226994|TAO:0001973|ZFA:0005434|NCIT:C94568	hp.json	tooth cone|tooth cusp|cusp	http://purl.obolibrary.org/obo/UBERON_0006844		vertebrate_core
UBERON:0006841	biolink:AnatomicalEntity	central vein of liver	Vein that is central to a lobule in the liver.	FMA:17544|ZFA:0005168|TAO:0005168|NCIT:C32281	hp.json	vena centralis (hepar)|central vein|terminal hepatic venule|terminal branch of hepatic vein	http://purl.obolibrary.org/obo/UBERON_0006841		vertebrate_core|human_reference_atlas
HP:0006904	biolink:PhenotypicFeature	Late-onset spinocerebellar degeneration		UMLS:C1856604	hp.json		http://purl.obolibrary.org/obo/HP_0006904		
HP:0006906	biolink:PhenotypicFeature	Congenital intracerebral calcification	The presence of calcium deposition within brain structures that is present already at the time of birth.	UMLS:C4024966	hp.json		http://purl.obolibrary.org/obo/HP_0006906		
CHEBI:33484	biolink:ChemicalSubstance	chalcogen oxoacid			hp.json	chalcogen oxoacids|chalcogen oxoacid	http://purl.obolibrary.org/obo/CHEBI_33484		3_STAR
CHEBI:33485	biolink:ChemicalSubstance	chalcogen oxoanion			hp.json	chalcogen oxoanion|chalcogen oxoanions	http://purl.obolibrary.org/obo/CHEBI_33485		3_STAR
HP:0006901	biolink:PhenotypicFeature	obsolete Impaired thermal sensitivity			hp.json		http://purl.obolibrary.org/obo/HP_0006901		
HP:0006903	biolink:PhenotypicFeature	Congenital peripheral neuropathy		UMLS:C4024967	hp.json		http://purl.obolibrary.org/obo/HP_0006903		
UBERON:0006834	biolink:AnatomicalEntity	uterus or analog	A subdivision of a the reproductive tract in a female organism that is the site of embryo development.	FBbt:00004924|WBbt:0006760|TADS:0000421	hp.json	uterus	http://purl.obolibrary.org/obo/UBERON_0006834		grouping_class
UBERON:0006833	biolink:AnatomicalEntity	lumen of trachea	An anatomical space that surrounded_by a trachea.	FMA:7469	hp.json	lumen of cartilaginous trachea|tracheal lumen	http://purl.obolibrary.org/obo/UBERON_0006833		
CHEBI:57433	biolink:ChemicalSubstance	sarcosine zwitterion	An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of sarcosine; major species at pH 7.3.	MetaCyc:SARCOSINE|Gmelin:323777	hp.json	(methylazaniumyl)acetate|sarcosine|2-(methylazaniumyl)acetate|(methylammonio)acetate	http://purl.obolibrary.org/obo/CHEBI_57433		3_STAR
CHEBI:33482	biolink:ChemicalSubstance	sulfur oxoanion			hp.json	sulfur oxoanions|sulfur oxoanion|oxoanions of sulfur	http://purl.obolibrary.org/obo/CHEBI_33482		3_STAR
GO:0007618	biolink:BiologicalProcess	mating	The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.		hp.json		http://purl.obolibrary.org/obo/GO_0007618		
GO:0007617	biolink:BiologicalProcess	mating behavior	The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.	Wikipedia:Mating_behaviour	hp.json	mating behaviour	http://purl.obolibrary.org/obo/GO_0007617		
GO:0007613	biolink:BiologicalProcess	memory	The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).	Wikipedia:Memory	hp.json		http://purl.obolibrary.org/obo/GO_0007613		
UBERON:0006815	biolink:AnatomicalEntity	areolar connective tissue	Loose connective tissue located at the outer and inner layers of organs. Examples: submucosal connective tissue, tunica adventitia of artery, papillary dermis, superficial fascia of dorsum of hand.	SCTID:68477002|AAO:0000027|FMA:63897	hp.json	loose connective tissue|loose areolar connective tissue|areolar tissue	http://purl.obolibrary.org/obo/UBERON_0006815		
GO:0007611	biolink:BiologicalProcess	learning or memory	The acquisition and processing of information and/or the storage and retrieval of this information over time.		hp.json		http://purl.obolibrary.org/obo/GO_0007611		
GO:0007610	biolink:BiologicalProcess	behavior	The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.	Wikipedia:Behavior	hp.json	behaviour|behavioural response to stimulus|single-organism behavior|behavioral response to stimulus	http://purl.obolibrary.org/obo/GO_0007610		gocheck_do_not_manually_annotate|goslim_flybase_ribbon|goslim_agr
CHEBI:33459	biolink:ChemicalSubstance	pnictogen oxoanion			hp.json	pnictogen oxoanion|pnictogen oxoanions	http://purl.obolibrary.org/obo/CHEBI_33459		3_STAR
CHEBI:33452	biolink:ChemicalSubstance	benzylic group	Arylmethyl groups and derivatives formed by substitution: ArCR2-.		hp.json	benzylic group|benzylic groups|benzylic groups|groupe benzylique	http://purl.obolibrary.org/obo/CHEBI_33452		3_STAR
CHEBI:33457	biolink:ChemicalSubstance	phosphorus oxoacid	A pnictogen oxoacid which contains phosphorus and oxygen, at least one hydrogen atom bound to oxygen, and forms an ion by the loss of one or more protons.		hp.json	Oxosaeure des Phosphors|oxoacids of phosphorus|phosphorus oxoacid|phosphorus oxoacids	http://purl.obolibrary.org/obo/CHEBI_33457		3_STAR
UBERON:0006822	biolink:AnatomicalEntity	proximal epiphysis of ulna	The head of ulna presents an articular surface, part of which, of an oval or semilunar form, is directed downward, and articulates with the upper surface of the triangular articular disk which separates it from the wrist-joint; the remaining portion, directed lateralward, is narrow, convex, and received into the ulnar notch of the radius.	FMA:33751|galen:HeadOfUlna	hp.json	caput ulnae|head of ulna|caput ulnae|upper end of ulna|proximal end of ulna	http://purl.obolibrary.org/obo/UBERON_0006822		pheno_slim
GO:0007626	biolink:BiologicalProcess	locomotory behavior	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.		hp.json	locomotory behavioral response to stimulus|locomotory behavioural response to stimulus|behavior via locomotion|locomotion in response to stimulus|locomotory behaviour	http://purl.obolibrary.org/obo/GO_0007626		goslim_drosophila
UBERON:0006805	biolink:AnatomicalEntity	sternal end of clavicle	Medial end of the clavicle, which usually lies on the ventral side of the epicoracoid cartilage, just posterior to the epicoracoid bridge.	FMA:23297|AAO:0000812	hp.json	extremitas medialis|medial end|extremitas sternalis claviculae|medial end of clavicle|extremitas sternalis (clavicula)|proximal epyphysis of clavicle	http://purl.obolibrary.org/obo/UBERON_0006805		
GO:0007623	biolink:BiologicalProcess	circadian rhythm	Any biological process in an organism that recurs with a regularity of approximately 24 hours.	Wikipedia:Circadian_rhythm	hp.json	response to circadian rhythm|circadian process|circadian response	http://purl.obolibrary.org/obo/GO_0007623		goslim_plant|goslim_drosophila
GO:0007622	biolink:BiologicalProcess	rhythmic behavior	The specific behavior of an organism that recur with measured regularity.		hp.json	rhythmic behavioural response to stimulus|rhythmic behavioral response to stimulus|rhythmic behaviour	http://purl.obolibrary.org/obo/GO_0007622		
GO:0007620	biolink:BiologicalProcess	copulation	The act of sexual union between male and female, involving the transfer of sperm.		hp.json		http://purl.obolibrary.org/obo/GO_0007620		
UBERON:0006813	biolink:AnatomicalEntity	nasal skeleton	Structural framework that provides support to the nasal sacs and ducts.	AAO:0000320|FMA:60116	hp.json	skeleton of nose	http://purl.obolibrary.org/obo/UBERON_0006813		pheno_slim
UBERON:0006812	biolink:AnatomicalEntity	mental foramen	The mental foramen is one of two holes ('foramina') located on the anterior surface of the mandible. It permits passage of the mental nerve and vessels. The mental foramen descends slightly in edentulous individuals.	AAO:0000298|MESH:D000080383|FMA:53171	hp.json	mental foramina|foramen mentalis|foramen mentale	http://purl.obolibrary.org/obo/UBERON_0006812		
UBERON:0006810	biolink:AnatomicalEntity	olecranon	The olecranon is a large, thick, curved bony eminence of the forearm that projects behind the elbow. It is situated at the upper (proximal) end of the ulna, one of the two bones in the forearm. When the hand faces forward the olecranon faces towards the back (posteriorly). It is bent forward at the summit so as to present a prominent lip which is received into the olecranon fossa of the humerus in extension of the forearm. Its base is contracted where it joins the body and the narrowest part of the upper end of the ulna. Its posterior surface, directed backward, is triangular, smooth, subcutaneous, and covered by a bursa. Its superior surface is of quadrilateral form, marked behind by a rough impression for the insertion of the Triceps brachii; and in front, near the margin, by a slight transverse groove for the attachment of part of the posterior ligament of the elbow-joint. Its anterior surface is smooth, concave, and forms the upper part of the semilunar notch. Its borders present continuations of the groove on the margin of the superior surface; they serve for the attachment of ligaments, viz. , the back part of the ulnar collateral ligament medially, and the posterior ligament laterally. From the medial border a part of the Flexor carpi ulnaris arises; while to the lateral border the anconeus muscle is attached.	FMA:39795|UMLS:C0223710|AAO:0000843|NCIT:C33200	hp.json	olecranon process of ulna|olecranon process|ulnar process	http://purl.obolibrary.org/obo/UBERON_0006810		pheno_slim
CHEBI:33461	biolink:ChemicalSubstance	phosphorus oxoanion			hp.json	oxoanions of phosphorus|phosphorus oxoanion|phosphorus oxoanions	http://purl.obolibrary.org/obo/CHEBI_33461		3_STAR
NCBITaxon:1329799	biolink:OrganismalEntity	Archelosauria		PMID:22839753|PMID:25450099|GC_ID:1	hp.json	Testudines + Archosauria group|Archosauria-Testudines	http://purl.obolibrary.org/obo/NCBITaxon_1329799		
UBERON:0004219	biolink:AnatomicalEntity	urethra smooth muscle layer	A portion of smooth muscle tissue that is part of a urethra [Automatically generated definition].	EMAPA:36630|MA:0001691|FMA:76909	hp.json	smooth muscle tissue of urethra|muscular layer of urethra|smooth muscle of urethra|muscle layer of urethra|urethral smooth muscle|urethra smooth muscle tissue|tunica muscularis urethrae|muscular coat of urethra	http://purl.obolibrary.org/obo/UBERON_0004219		
RO:0002090	biolink:NamedThing	immediately_precedes		RO:0002090	hp.json		http://purl.obolibrary.org/obo/RO_0002090		ro-eco
HP:0006937	biolink:PhenotypicFeature	Impaired distal tactile sensation	A reduced sense of touch (tactile sensation) on the skin of the distal limbs. This is usually tested with a wisp of cotton or a fine camel's hair brush, by asking patients to say 'now' each time they feel the stimulus.	UMLS:C4021583	hp.json	Decreased distal touch sense|Decreased touch sensation in extremities	http://purl.obolibrary.org/obo/HP_0006937		
HP:0006938	biolink:PhenotypicFeature	Impaired vibration sensation at ankles	A decrease in the ability to perceive vibration at the ankles. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to the malleoli of the ankles.	UMLS:C1854372	hp.json	Decreased vibration sense at ankles|Decreased vibration sense in feet|Impaired vibration sensation at ankles	http://purl.obolibrary.org/obo/HP_0006938		
UBERON:0004220	biolink:AnatomicalEntity	large intestine smooth muscle	A portion of smooth muscle tissue that is part of a large intestine [Automatically generated definition].	EMAPA:35469|MA:0001547	hp.json	smooth muscle tissue of large intestine|smooth muscle of large intestine|involuntary muscle of large intestine|non-striated muscle of large intestine|large intestine involuntary muscle|large intestine smooth muscle tissue|large intestine non-striated muscle	http://purl.obolibrary.org/obo/UBERON_0004220		
UBERON:0004221	biolink:AnatomicalEntity	intestine smooth muscle	A portion of smooth muscle tissue that is part of a intestine [Automatically generated definition].	BTO:0000643|MA:0001539|NCIT:C49243|EMAPA:35443|EMAPA:35441|UMLS:C1708547	hp.json	involuntary muscle of intestine|non-striated muscle of intestine|intestine smooth muscle tissue|bowel non-striated muscle|smooth muscle tissue of bowel|bowel involuntary muscle|smooth muscle of bowel|bowel smooth muscle|involuntary muscle of bowel|bowel smooth muscle tissue|non-striated muscle of bowel|intestine non-striated muscle|intestinal muscularis|smooth muscle tissue of intestine|intestinal smooth muscle|intestine involuntary muscle|smooth muscle of intestine	http://purl.obolibrary.org/obo/UBERON_0004221		pheno_slim
HP:0006934	biolink:PhenotypicFeature	Congenital nystagmus	Nystagmus dating from or present at birth.	SNOMEDCT_US:64635004|MSH:D020417|UMLS:C0700501	hp.json	Nystagmus, congenital	http://purl.obolibrary.org/obo/HP_0006934		
CHEBI:33431	biolink:ChemicalSubstance	elemental chlorine			hp.json		http://purl.obolibrary.org/obo/CHEBI_33431		3_STAR
CHEBI:33432	biolink:ChemicalSubstance	monoatomic chlorine			hp.json	atomic chlorine	http://purl.obolibrary.org/obo/CHEBI_33432		3_STAR
CHEBI:33433	biolink:ChemicalSubstance	monoatomic halogen			hp.json	monoatomic halogens	http://purl.obolibrary.org/obo/CHEBI_33433		3_STAR
CHEBI:33434	biolink:ChemicalSubstance	elemental halogen			hp.json	elemental halogens|elemental halogen	http://purl.obolibrary.org/obo/CHEBI_33434		3_STAR
HP:0006930	biolink:PhenotypicFeature	Frontoparietal cortical dysplasia	The presence of developmental dysplasia of the cortex of frontal lobe and the cortex of parietal lobe.	UMLS:C4024959	hp.json		http://purl.obolibrary.org/obo/HP_0006930		
HP:0006931	biolink:PhenotypicFeature	Pericallosal lipoma	Pericallosal lipomas are congenital soft masses of adipose cells encapsulated by a thin layer of fibrous tissue, appearing adjacent to the corpus callosum of the brain.	UMLS:C1333160	hp.json	Lipoma of corpus callosum	http://purl.obolibrary.org/obo/HP_0006931		
HP:0006932	biolink:PhenotypicFeature	Transient psychotic episodes		UMLS:C4024958	hp.json		http://purl.obolibrary.org/obo/HP_0006932		
UBERON:0004228	biolink:AnatomicalEntity	urinary bladder smooth muscle	A portion of smooth muscle tissue that is part of a urinary bladder [Automatically generated definition].	MA:0001697|CALOHA:TS-1087|EMAPA:37791|BTO:0001849	hp.json	bladder smooth muscle tissue|smooth muscle of urinary bladder|urinary bladder involuntary muscle|urinary bladder muscle|bladder non-striated muscle|involuntary muscle of urinary bladder|non-striated muscle of urinary bladder|smooth muscle tissue of bladder|smooth muscle of bladder|urinary bladder smooth muscle tissue|bladder smooth muscle|involuntary muscle of bladder|non-striated muscle of bladder|bladder involuntary muscle|urinary bladder non-striated muscle|smooth muscle layer of bladder|smooth muscle tissue of urinary bladder	http://purl.obolibrary.org/obo/UBERON_0004228		
UBERON:0004226	biolink:AnatomicalEntity	gastrointestinal system smooth muscle	A portion of smooth muscle tissue that is part of a digestive system [Automatically generated definition].	EMAPA:35117|MA:0001523	hp.json	smooth muscle tissue of gastrointestinal system	http://purl.obolibrary.org/obo/UBERON_0004226		
UBERON:0004227	biolink:AnatomicalEntity	kidney pelvis smooth muscle	The smooth muscle tissue surrounding the urothelium of the kidney pelvis.	MA:0002631|EMAPA:28120|FMA:262022	hp.json	renal pelvis smooth muscle|smooth muscle tissue of renal pelvis|kidney pelvis smooth muscle|pelvic smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004227		pheno_slim
UBERON:0004224	biolink:AnatomicalEntity	muscular coat of vas deferens	A muscular coat that is part of a vas deferens [Automatically generated definition].	MA:0001750|EMAPA:29270|FMA:19239	hp.json	muscle layer of vas deferens|tunica muscularis ductus deferentis|tunica muscularis (ductus deferens)|muscularis of vas deferens|muscular coat of ductus deferens|muscular layer of ductus deferens|muscle layer of deferent duct|muscle layer of ductus deferens	http://purl.obolibrary.org/obo/UBERON_0004224		
UBERON:0004225	biolink:AnatomicalEntity	respiratory system smooth muscle	A portion of smooth muscle tissue that is part of a respiratory system [Automatically generated definition].	EMAPA:35734|BTO:0001660|MA:0001830	hp.json	respiratory smooth muscle|airway smooth muscle cell|airway smooth muscle|smooth muscle of respiratory system	http://purl.obolibrary.org/obo/UBERON_0004225		
UBERON:0004222	biolink:AnatomicalEntity	stomach smooth muscle	A portion of smooth muscle tissue that is part of a stomach [Automatically generated definition].	EMAPA:35823|MA:0001627|BTO:0001818	hp.json	smooth muscle of stomach|gastric muscle|stomach smooth muscle tissue|ventriculus involuntary muscle|involuntary muscle of stomach|non-striated muscle of stomach|ventriculus smooth muscle tissue|stomach muscle|ventriculus non-striated muscle|smooth muscle tissue of ventriculus|smooth muscle of ventriculus|stomach involuntary muscle|ventriculus smooth muscle|stomach non-striated muscle|involuntary muscle of ventriculus|gastric smooth muscle|smooth muscle tissue of stomach|non-striated muscle of ventriculus	http://purl.obolibrary.org/obo/UBERON_0004222		
UBERON:0004223	biolink:AnatomicalEntity	vagina smooth muscle	A portion of smooth muscle tissue that is part of a vagina [Automatically generated definition].	EMAPA:30997|BTO:0004999|MA:0001733	hp.json	smooth muscle of vagina|smooth muscle tissue of vagina|vaginal smooth muscle|vagina smooth muscle|vagina non-striated muscle|vagina involuntary muscle|vagina smooth muscle tissue|non-striated muscle of vagina|involuntary muscle of vagina	http://purl.obolibrary.org/obo/UBERON_0004223		
RO:0002081	biolink:NamedThing	before or simultaneous with			hp.json		http://purl.obolibrary.org/obo/RO_0002081		ro-eco
GO:0007606	biolink:BiologicalProcess	sensory perception of chemical stimulus	The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.		hp.json	chemosensory perception	http://purl.obolibrary.org/obo/GO_0007606		
GO:0007605	biolink:BiologicalProcess	sensory perception of sound	The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.	Wikipedia:Hearing_(sense)	hp.json	perception of sound|hearing	http://purl.obolibrary.org/obo/GO_0007605		
RO:0002082	biolink:NamedThing	simultaneous with		RO:0002082	hp.json		http://purl.obolibrary.org/obo/RO_0002082		ro-eco
UBERON:0004208	biolink:AnatomicalEntity	nephrogenic mesenchyme	Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchymal cells in the nephron.		hp.json	mesenchyme of nephron|nephron mesenchyme	http://purl.obolibrary.org/obo/UBERON_0004208		
GO:0007601	biolink:BiologicalProcess	visual perception	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.	Wikipedia:Visual_perception	hp.json	vision|sense of sight|sensory visual perception	http://purl.obolibrary.org/obo/GO_0007601		
GO:0007600	biolink:BiologicalProcess	sensory perception	The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.	Wikipedia:Perception	hp.json		http://purl.obolibrary.org/obo/GO_0007600		goslim_drosophila
UBERON:0004209	biolink:AnatomicalEntity	renal vesicle	The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells.		hp.json	stage I nephron	http://purl.obolibrary.org/obo/UBERON_0004209		
PATO:0002359	biolink:NamedThing	broad	A quality inhering in a bearer by virtue of the bearer's width being notably higher than its length.		hp.json		http://purl.obolibrary.org/obo/PATO_0002359		value_slim
PATO:0002358	biolink:NamedThing	ridged			hp.json		http://purl.obolibrary.org/obo/PATO_0002358		
HP:0006949	biolink:PhenotypicFeature	Episodic peripheral neuropathy		UMLS:C1848695	hp.json		http://purl.obolibrary.org/obo/HP_0006949		
RO:0002086	biolink:NamedThing	ends after			hp.json		http://purl.obolibrary.org/obo/RO_0002086		ro-eco
RO:0002087	biolink:NamedThing	immediately preceded by	X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y)	RO:0002087	hp.json	is directly preceded by|is immediately preceded by|directly preceded by|starts_at_end_of	http://purl.obolibrary.org/obo/RO_0002087		
UBERON:0006872	biolink:AnatomicalEntity	handplate apical ectodermal ridge	An apical ectodermal ridge that is part of a handplate.	EHDAA2:0000729|EMAPA:17247	hp.json		http://purl.obolibrary.org/obo/UBERON_0006872		
HP:0006944	biolink:PhenotypicFeature	Abolished vibration sense	A complete loss of the ability to perceive vibration.	UMLS:C1837520	hp.json	Apallesthesia	http://purl.obolibrary.org/obo/HP_0006944		
UBERON:0006871	biolink:AnatomicalEntity	embryonic footplate	The distal elements of the developing limb of vertebrates that will give rise to the pes (foot).	FMA:296800|NCIT:C34177|EHDAA:5143|EMAPA:17249|EHDAA:6096|UMLS:C1517291	hp.json	foot disk|foot plate|distal part of hindlimb bud|footplate	http://purl.obolibrary.org/obo/UBERON_0006871		pheno_slim
HP:0006946	biolink:PhenotypicFeature	Recurrent meningitis	An increased susceptibility to meningitis as manifested by a medical history of recurrent episodes of meningitis.	UMLS:C0746495	hp.json		http://purl.obolibrary.org/obo/HP_0006946		
HP:0006943	biolink:PhenotypicFeature	Diffuse spongiform leukoencephalopathy		UMLS:C1858857	hp.json		http://purl.obolibrary.org/obo/HP_0006943		
UBERON:0004217	biolink:AnatomicalEntity	upper arm nerve	A nerve that is part of a forelimb stylopod [Automatically generated definition].	EMAPA:37337|MA:0000607	hp.json		http://purl.obolibrary.org/obo/UBERON_0004217		
UBERON:0004218	biolink:AnatomicalEntity	lower leg nerve	A nerve that is part of a lower leg [Automatically generated definition].	EMAPA:37345|MA:0000679	hp.json		http://purl.obolibrary.org/obo/UBERON_0004218		
UBERON:0004215	biolink:AnatomicalEntity	back nerve	A nerve that is part of a back [Automatically generated definition].	MA:0000497|EMAPA:37268	hp.json	nerve of back	http://purl.obolibrary.org/obo/UBERON_0004215		
UBERON:0004216	biolink:AnatomicalEntity	lower arm nerve	A nerve that is part of a lower arm [Automatically generated definition].	EMAPA:37338|MA:0000601	hp.json		http://purl.obolibrary.org/obo/UBERON_0004216		
UBERON:0006877	biolink:AnatomicalEntity	vasculature of liver	A vasculature that is part of a liver.	EHDAA2:0003454|EMAPA:35501|FMA:73748	hp.json	liver vascular system|hepatic vascular element|hepatic vasculature|liver vascular element	http://purl.obolibrary.org/obo/UBERON_0006877		pheno_slim
UBERON:0006876	biolink:AnatomicalEntity	vasculature of organ	A vasculature that is part of a organ.	FMA:74612	hp.json	organ vasculature|set of blood vessels of organ	http://purl.obolibrary.org/obo/UBERON_0006876		non_informative
UBERON:0004214	biolink:AnatomicalEntity	upper leg nerve	A nerve that is part of a hindlimb stylopod [Automatically generated definition].	MA:0000685|EMAPA:37344	hp.json	lower extremity stylopod nerve|hindlimb stylopod nerve|hind limb stylopod nerve|thigh RELATED	http://purl.obolibrary.org/obo/UBERON_0004214		
UBERON:0006875	biolink:AnatomicalEntity	embryonic handplate	The distal elements of the developing limb of vertebrates that will give rise to the manus (hand).	NCIT:C34185|EHDAA:6242|FMA:296794|EHDAA:4194|EMAPA:17245|UMLS:C1512334	hp.json	distal part of forelimb bud|handplate|hand plate	http://purl.obolibrary.org/obo/UBERON_0006875		
UBERON:0004211	biolink:AnatomicalEntity	nephron epithelium	The nephron epithelium is a tissue that covers the surface of a nephron.		hp.json	nephron epithelial tissue|epithelium of nephron|epithelial tissue of nephron	http://purl.obolibrary.org/obo/UBERON_0004211		
UBERON:0004212	biolink:AnatomicalEntity	glomerular capillary	The small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus.	EMAPA:28245|MA:0002587|NCIT:C32684|UMLS:C0226356|FMA:274259|ZFA:0005284|TAO:0005284	hp.json	capillary vessel of renal glomerulus|renal glomerulus blood capillary|capillary of renal glomerulus|glomerular capillaries|glomerular capillary system|renal glomerulus capillary vessel|blood capillary of renal glomerulus|renal glomerulus capillary	http://purl.obolibrary.org/obo/UBERON_0004212		pheno_slim|human_reference_atlas|vertebrate_core
GO:0007608	biolink:BiologicalProcess	sensory perception of smell	The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.	Wikipedia:Olfaction	hp.json	olfaction|smell perception|scent perception|sense of smell	http://purl.obolibrary.org/obo/GO_0007608		
HP:0006919	biolink:PhenotypicFeature	Abnormal aggressive, impulsive or violent behavior		UMLS:C4024963	hp.json	Aggressive/violent behavior|Abnormal aggressive, impulsive or violent behaviour|Aggressive/violent behaviour	http://purl.obolibrary.org/obo/HP_0006919		
HP:0006915	biolink:PhenotypicFeature	Inability to walk by childhood/adolescence		UMLS:C1859200	hp.json	Inability to walk by childhood/adolescence	http://purl.obolibrary.org/obo/HP_0006915		
HP:0006916	biolink:PhenotypicFeature	Intraaxonal accumulation of curvilinear autofluorescent lipopigment storage material	Curvilinear intracellular accumulation of autofluorescent lipopigment storage material within axons.	UMLS:C1832339|UMLS:C4024964	hp.json	Intraaxonal accumulation of curvilinear profiles	http://purl.obolibrary.org/obo/HP_0006916		
HP:0006918	biolink:PhenotypicFeature	Diffuse cerebral sclerosis		MSH:D002549|UMLS:C0007795|SNOMEDCT_US:49692006	hp.json		http://purl.obolibrary.org/obo/HP_0006918		
UBERON:0006861	biolink:AnatomicalEntity	diaphysis proper	Subdivision of long bone which forms the part of the bone between two metaphyses. Note that the diaphysis includes the metaphyses, but the diaphysis proper excludes these.	FMA:32688|MA:0002803	hp.json	body proper of long bone|shaft proper of long bone|long bone diaphysis	http://purl.obolibrary.org/obo/UBERON_0006861		pheno_slim
HP:0006913	biolink:PhenotypicFeature	Frontal cortical atrophy	Atrophy of the frontal cortex.	UMLS:C4024965	hp.json	Frontal cortex degeneration	http://purl.obolibrary.org/obo/HP_0006913		
UBERON:0006868	biolink:AnatomicalEntity	seminal fluid secreting gland	A gland that secretes a seminal fluid.	WBbt:0006870|FBbt:00004958	hp.json		http://purl.obolibrary.org/obo/UBERON_0006868		organ_slim|grouping_class
UBERON:0006867	biolink:AnatomicalEntity	anal part of perineum	The anal triangle is the posterior part of the perineum. It contains the anal canal. [WP,unvetted].	FMA:20347	hp.json	anal region|anal triangle|regio analis	http://purl.obolibrary.org/obo/UBERON_0006867		
UBERON:0006866	biolink:AnatomicalEntity	terminal part of digestive tract	The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus.	WBbt:0005773|FBbt:00005756	hp.json	terminal section of digestive tract|rectal part of digestive tract|rectum	http://purl.obolibrary.org/obo/UBERON_0006866		
UBERON:0004205	biolink:AnatomicalEntity	inner medullary collecting duct	The inner medullary collecting duct is the portion of the collecting duct that lies in the renal inner medulla.	MA:0002598|EMAPA:28370|BTO:0004544	hp.json	kidney inner medulla collecting duct|papillary collecting duct|inner renal medulla collecting duct	http://purl.obolibrary.org/obo/UBERON_0004205		human_reference_atlas
UBERON:0006865	biolink:AnatomicalEntity	metaphysis of femur	A metaphysis that is part of a femur.	FMA:32875|MA:0003052|EMAPA:37540	hp.json	femoral metaphysis	http://purl.obolibrary.org/obo/UBERON_0006865		pheno_slim
UBERON:0004203	biolink:AnatomicalEntity	cortical collecting duct	The cortical collecting duct is the portion of the collecting duct that resides in the renal cortex.	MA:0002600|EMAPA:28130|BTO:0002643	hp.json	renal cortex collecting duct|kidney cortex collecting duct	http://purl.obolibrary.org/obo/UBERON_0004203		human_reference_atlas
UBERON:0006864	biolink:AnatomicalEntity	distal metaphysis of femur	A distal metaphysis that is part of a femur.	FMA:32881	hp.json		http://purl.obolibrary.org/obo/UBERON_0006864		pheno_slim
UBERON:0004200	biolink:AnatomicalEntity	kidney pyramid	Kidney pyramids are the conical arrangements of tubules that constitute the renal medulla in a multi-lobed mammalian kidney; they contain the loops of Henle and the medullary collecting ducts.	MA:0001654|UMLS:C1514613|NCIT:C33436|BTO:0003926|UMLS:C0227629|NCIT:C12886|FMA:258870	hp.json	Malpighian pyramid|pyramis renalis|renal pyramid|Malphigian pyramid|medullary pyramid|Malpighian pyramid|pyramid of Malpighi|pyramides renales|pyramid of Malphigi|pyramid|renal medullary region	http://purl.obolibrary.org/obo/UBERON_0004200		pheno_slim|human_reference_atlas
UBERON:0006863	biolink:AnatomicalEntity	proximal metaphysis of femur	A proximal metaphysis that is part of a femur.	FMA:32878	hp.json		http://purl.obolibrary.org/obo/UBERON_0006863		pheno_slim
UBERON:0006862	biolink:AnatomicalEntity	diaphysis of femur	A diaphysis that is part of a femur[Automatically generated definition].	EMAPA:37538|FMA:32847|MA:0003055|NCIT:C96209	hp.json	shaft of femur|femoral diaphysis|body of femur|femoral shaft|corpus femoris	http://purl.obolibrary.org/obo/UBERON_0006862		pheno_slim
UBERON:0006849	biolink:AnatomicalEntity	scapula	Endochondral bone that is dorsoventrally compressed and provides attachment site for muscles of the pectoral appendage.	CALOHA:TS-0897|VSAO:0000157|UMLS:C0036277|VHOG:0001398|EMAPA:18722|galen:Scapula|FMA:13394|ZFA:0000583|BTO:0001218|OpenCyc:Mx4rvVji0JwpEbGdrcN5Y29ycA|GAID:186|MA:0001330|TAO:0000583|NCIT:C12783|AAO:0000751|MESH:D012540|EFO:0001400	hp.json	scapulae|shoulder blade|scapulas|scapula bone	http://purl.obolibrary.org/obo/UBERON_0006849		uberon_slim|pheno_slim|efo_slim
CHEBI:33429	biolink:ChemicalSubstance	monoatomic monoanion			hp.json	monoatomic monoanions	http://purl.obolibrary.org/obo/CHEBI_33429		3_STAR
HP:0006926	biolink:PhenotypicFeature	Metachromatic leukodystrophy variant		UMLS:C4024961	hp.json		http://purl.obolibrary.org/obo/HP_0006926		
HP:0006927	biolink:PhenotypicFeature	Unilateral polymicrogyria	Excessive number of small gyri (convolutions) on the surface of one side of the brain.	UMLS:C4024960|SNOMEDCT_US:715905006	hp.json		http://purl.obolibrary.org/obo/HP_0006927		
HP:0006929	biolink:PhenotypicFeature	Hypoglycemic encephalopathy	Brain damage related to a lowering of blood glucose below a critical level (around 30 mg/dl), which may lead to confusion, lethargy and delirium followed by seizures and coma. Prolonged hypoglycemia may lead to irreversible brain damage.	UMLS:C0149877|SNOMEDCT_US:64624009	hp.json		http://purl.obolibrary.org/obo/HP_0006929		
NCBITaxon:6072	biolink:OrganismalEntity	Eumetazoa		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_6072		
CHEBI:33424	biolink:ChemicalSubstance	sulfur oxoacid derivative			hp.json	sulfur oxoacid derivatives|sulfur oxoacid derivative	http://purl.obolibrary.org/obo/CHEBI_33424		3_STAR
HP:0006921	biolink:PhenotypicFeature	Axial muscle stiffness	Stiffness (a condition in which muscles cannot be moved quickly without accompanying pain or spasm) of the axial musculature.	UMLS:C4024962	hp.json		http://purl.obolibrary.org/obo/HP_0006921		
UBERON:0006858	biolink:AnatomicalEntity	adrenal/interrenal gland	This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells[GO].	VHOG:0001141	hp.json	adrenal gland/interrenal tissue|adrenal gland - interrenal gland|adrenal - interrenal gland|suprarenal gland - interrenal gland	http://purl.obolibrary.org/obo/UBERON_0006858		homology_grouping|organ_slim
UBERON:0006855	biolink:AnatomicalEntity	muscular coat of ureter	A muscular coat that is part of a ureter.	FMA:15893|MA:0002654|EMAPA:28811	hp.json	muscularis of ureter|tunica muscularis ureteris|muscular layer of ureter|ureteral smooth muscle layer|muscular coat of ureter|tunica muscularis (ureter)	http://purl.obolibrary.org/obo/UBERON_0006855		
HP:0100127	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022294	hp.json	Irregular end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100127		
HP:0100128	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022293	hp.json	Increased bone density of end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100128		
HP:0100125	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022296	hp.json	Enlarged end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100125		
RO:0002170	biolink:NamedThing	connected to	a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b	RO:0002170	hp.json		http://purl.obolibrary.org/obo/RO_0002170		
HP:0100126	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022295	hp.json	Fragmentation of the end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100126		
HP:0100123	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022298	hp.json	Bracket shaped end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100123		
HP:0100124	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022297	hp.json	Cone-shaped end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100124		
HP:0100121	biolink:PhenotypicFeature	Triangular epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022300	hp.json	Triangular end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100121		
HP:0100122	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022299	hp.json	Absent end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100122		
RO:0002176	biolink:NamedThing	connects	Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship.	RO:0002176	hp.json		http://purl.obolibrary.org/obo/RO_0002176		
PATO:0002304	biolink:NamedThing	increased process quality	A quality of a process that has a value that is increased compared to normal or average.		hp.json		http://purl.obolibrary.org/obo/PATO_0002304		
PATO:0002305	biolink:NamedThing	increased object quality	A quality of an object that has a value that is increased compared to normal or average.		hp.json		http://purl.obolibrary.org/obo/PATO_0002305		
HP:0100120	biolink:PhenotypicFeature	Stippling of the epiphysis of the middle phalanx of the 2nd toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the middle phalanx of the 2nd toe.	UMLS:C4022301	hp.json	Speckled calcifications in of the end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100120		
RO:0002177	biolink:NamedThing	attached to part of	a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b.	RO:0002177	hp.json		http://purl.obolibrary.org/obo/RO_0002177		
PATO:0002302	biolink:NamedThing	decreased process quality	A quality of a process that has a value that is decreased compared to normal or average.		hp.json		http://purl.obolibrary.org/obo/PATO_0002302		
RO:0002178	biolink:NamedThing	supplies	Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy.	RO:0002178	hp.json		http://purl.obolibrary.org/obo/RO_0002178		
PATO:0002303	biolink:NamedThing	decreased object quality	A quality of an object that has a value that is decreased compared to normal or average.		hp.json		http://purl.obolibrary.org/obo/PATO_0002303		
RO:0002179	biolink:NamedThing	drains	Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure.	RO:0002179	hp.json	drains from|drains blood from	http://purl.obolibrary.org/obo/RO_0002179		
GO:0044782	biolink:BiologicalProcess	cilium organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.		hp.json	microtubule-based flagellum organization	http://purl.obolibrary.org/obo/GO_0044782		goslim_drosophila|goslim_generic
PATO:0002309	biolink:NamedThing	fiber shaped	A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter.		hp.json		http://purl.obolibrary.org/obo/PATO_0002309		value_slim
GO:0005172	biolink:MolecularActivity	vascular endothelial growth factor receptor binding	Binding to a vascular endothelial growth factor receptor.		hp.json	VEGFR binding|vascular endothelial growth factor receptor ligand|vascular endothelial growth factor|VEGF receptor binding	http://purl.obolibrary.org/obo/GO_0005172		
GO:0005173	biolink:MolecularActivity	stem cell factor receptor binding	Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.		hp.json	stem cell factor receptor ligand|SCF|stem cell factor|KIT binding|SCFR binding	http://purl.obolibrary.org/obo/GO_0005173		
PATO:0002300	biolink:NamedThing	increased quality	A quality that has a value that is increased compared to normal or average.		hp.json		http://purl.obolibrary.org/obo/PATO_0002300		
GO:0042127	biolink:BiologicalProcess	regulation of cell population proliferation	Any process that modulates the frequency, rate or extent of cell proliferation.		hp.json	regulation of cell proliferation	http://purl.obolibrary.org/obo/GO_0042127		
PATO:0002301	biolink:NamedThing	decreased quality	A quality that has a value that is decreased compared to normal or average.		hp.json		http://purl.obolibrary.org/obo/PATO_0002301		
GO:0042129	biolink:BiologicalProcess	regulation of T cell proliferation	Any process that modulates the frequency, rate or extent of T cell proliferation.		hp.json	regulation of T-cell proliferation|regulation of T lymphocyte proliferation|regulation of T-lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0042129		
GO:0017157	biolink:BiologicalProcess	regulation of exocytosis	Any process that modulates the frequency, rate or extent of exocytosis.		hp.json		http://purl.obolibrary.org/obo/GO_0017157		
GO:0030133	biolink:CellularComponent	transport vesicle	Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.	NIF_Subcellular:sao885490876	hp.json	Golgi-vacuole transport vesicle|secretory vesicle|Golgi to vacuole transport vesicle|constitutive secretory pathway transport vesicle	http://purl.obolibrary.org/obo/GO_0030133		
HP:0100129	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the 2nd toe	A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the second toe.	UMLS:C4022292	hp.json		http://purl.obolibrary.org/obo/HP_0100129		
GO:0032790	biolink:BiologicalProcess	ribosome disassembly	The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.		hp.json	ribosome recycling|ribosome dissociation factor	http://purl.obolibrary.org/obo/GO_0032790		
HP:0100138	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022283	hp.json	Enlarged end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100138		
HP:0100139	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022282	hp.json	Fragmentation of the end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100139		
HP:0100136	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022285	hp.json	Bracket shaped end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100136		
HP:0100137	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022284	hp.json	Cone-shaped end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100137		
RO:0002160	biolink:Protein	only in taxon	U only_in_taxon T: U is a feature found in only in organisms of species of taxon T. The feature cannot be found in an organism of any species outside of (not subsumed by) that taxon. Down-propagates in U hierarchy, up-propagates in T hierarchy (species taxonomy). Implies applicable_to_taxon.	RO:0002160	hp.json	never_outside_taxon|specific_to|specific_to_taxon	http://purl.obolibrary.org/obo/RO_0002160		
HP:0100134	biolink:PhenotypicFeature	Abnormality of the axillary hair	Abnormality of the growth of the axillary hair. Axillary hair is part of the secondary sexual hair, which normally ensues during puberty.	UMLS:C4022287	hp.json		http://purl.obolibrary.org/obo/HP_0100134		
HP:0100135	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022286	hp.json	Absent end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100135		
HP:0100132	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022289	hp.json	Triangular end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100132		
HP:0100133	biolink:PhenotypicFeature	Abnormality of the pubic hair	Abnormality of the growth of the pubic hair. Pubic hair is part of the secondary sexual hair, which normally ensues during puberty.	UMLS:C4022288	hp.json	Abnormality of the pubic hair	http://purl.obolibrary.org/obo/HP_0100133		
GO:0032787	biolink:BiologicalProcess	monocarboxylic acid metabolic process	The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).		hp.json	monocarboxylate metabolic process|monocarboxylic acid metabolism	http://purl.obolibrary.org/obo/GO_0032787		goslim_yeast
HP:0100130	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022291	hp.json	Small end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100130		
HP:0100131	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the 2nd toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 2nd toe.	UMLS:C4022290	hp.json	Speckled calcifications in the end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100131		
GO:0042130	biolink:BiologicalProcess	negative regulation of T cell proliferation	Any process that stops, prevents or reduces the rate or extent of T cell proliferation.		hp.json	negative regulation of T-cell proliferation|negative regulation of T lymphocyte proliferation|negative regulation of T-lymphocyte proliferation|downregulation of T cell proliferation|down regulation of T cell proliferation|inhibition of T cell proliferation|down-regulation of T cell proliferation	http://purl.obolibrary.org/obo/GO_0042130		
RO:0002162	biolink:NamedThing	in taxon	x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed.	RO:0002162	hp.json		http://purl.obolibrary.org/obo/RO_0002162		ro-eco
PATO:0002317	biolink:NamedThing	parallelogram	A convex quadrilateral is a parallelogram if and only if any one of the following statements are true: 1. Each diagonal divides the quadrilateral into two congruent triangles with the same orientation. 2. The opposite sides are congruent in pairs. 3. The diagonals bisect each other. 4. The opposite angles are congruent in pairs. 5. The sum of the squares of the sides equals the sum of the squares of the diagonals. (This is the parallelogram law) 6.It possesses rotational symmetry. 7.One pair of opposite sides are parallel and congruent. 8.Two pairs of adjacent angles are supplementary.		hp.json		http://purl.obolibrary.org/obo/PATO_0002317		value_slim
RO:0002163	biolink:NamedThing	spatially disjoint from	A is spatially_disjoint_from B if and only if they have no parts in common		hp.json		http://purl.obolibrary.org/obo/RO_0002163		ro-eco
PATO:0002318	biolink:NamedThing	superelliptic	A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt		hp.json	Lamé curve	http://purl.obolibrary.org/obo/PATO_0002318		
RO:0002158	biolink:NamedThing	shares ancestor with	two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a.	RO:0002158	hp.json		http://purl.obolibrary.org/obo/RO_0002158		
RO:0002159	biolink:NamedThing	serially homologous to		RO:0002159	hp.json		http://purl.obolibrary.org/obo/RO_0002159		
UBERON:5102389	biolink:AnatomicalEntity	manual digit digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of manual digit plus the associated metapodial element.		hp.json	manual digit skeleton|manual digit	http://purl.obolibrary.org/obo/UBERON_5102389		
HP:0100149	biolink:PhenotypicFeature	Enlarged epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022272	hp.json	Enlarged end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100149		
HP:0100147	biolink:PhenotypicFeature	Bracket epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022274	hp.json	Bracket shaped end part of the middle bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0100147		
HP:0100148	biolink:PhenotypicFeature	Cone-shaped epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022273	hp.json	Cone-shaped end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100148		
HP:0100145	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022276	hp.json	Triangular end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100145		
HP:0100146	biolink:PhenotypicFeature	Absent epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022275	hp.json	Absent end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100146		
PR:Q05117	biolink:Protein	tartrate-resistant acid phosphatase type 5 (mouse)	A tartrate-resistant acid phosphatase type 5 that is encoded in the genome of mouse.	UniProtKB:Q05117	hp.json	TrATPase (mouse)|mACP5|Acp5|TR-AP (mouse)|T5ap|type 5 acid phosphatase (mouse)|Trap|tartrate-resistant acid ATPase (mouse)	http://purl.obolibrary.org/obo/PR_Q05117		
HP:0100143	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022278	hp.json	Small end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100143		
HP:0100144	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the 3rd toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 3rd toe.	UMLS:C4022277	hp.json	Speckled calcifications in the end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100144		
PATO:0002326	biolink:NamedThing	angle	An orientation inhering in a bearer by virtue of the bearer's placement at an angle.		hp.json		http://purl.obolibrary.org/obo/PATO_0002326		relational_slim|attribute_slim
HP:0100141	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022280	hp.json	Increased bone density of end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100141		
PATO:0002327	biolink:NamedThing	increased angle to	An angle which is relatively high.		hp.json		http://purl.obolibrary.org/obo/PATO_0002327		value_slim|relational_slim
HP:0100142	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the 3rd toe		UMLS:C4022279	hp.json		http://purl.obolibrary.org/obo/HP_0100142		
PATO:0002324	biolink:NamedThing	offset quality	The temporal relation between the end of the process with respect to a reference process.		hp.json	completeness|extent	http://purl.obolibrary.org/obo/PATO_0002324		attribute_slim
RO:0002156	biolink:NamedThing	derived by descent from	d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a.		hp.json		http://purl.obolibrary.org/obo/RO_0002156		
PATO:0002325	biolink:NamedThing	onset quality	The temporal relation between the start of the process with respect to a reference process.		hp.json	initiation	http://purl.obolibrary.org/obo/PATO_0002325		attribute_slim
HP:0100140	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022281	hp.json	Irregular end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100140		
RO:0002157	biolink:NamedThing	has derived by descendant	inverse of derived by descent from		hp.json		http://purl.obolibrary.org/obo/RO_0002157		
RO:0002150	biolink:NamedThing	continuous with	X continuous_with Y if and only if X and Y share a fiat boundary.	RO:0002150	hp.json		http://purl.obolibrary.org/obo/RO_0002150		
PATO:0002328	biolink:NamedThing	decreased angle to	An angle which is relatively low.		hp.json		http://purl.obolibrary.org/obo/PATO_0002328		value_slim|relational_slim
PATO:0002323	biolink:NamedThing	temporal distribution quality	A temporal distribution pattern of process occurrences within a regulation/reference process.		hp.json		http://purl.obolibrary.org/obo/PATO_0002323		attribute_slim
GO:0032774	biolink:BiologicalProcess	RNA biosynthetic process	The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.		hp.json	RNA synthesis|RNA biosynthesis|RNA formation|RNA anabolism	http://purl.obolibrary.org/obo/GO_0032774		
PR:Q07763	biolink:Protein	natural killer cell receptor 2B4 (mouse)	A natural killer cell receptor 2B4 that is encoded in the genome of mouse.	UniProtKB:Q07763	hp.json	mCD244|NKR2B4 (mouse)|SLAM family member 4 (mouse)|signaling lymphocytic activation molecule 4 (mouse)|non-MHC restricted killing associated (mouse)|Nmrk|2b4|NK cell type I receptor protein 2B4 (mouse)|SLAMF4 (mouse)|Cd244|CD244 (mouse)	http://purl.obolibrary.org/obo/PR_Q07763		
HP:0100158	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022263	hp.json	Bracket shaped end part of the innermost bone of 3rd toe	http://purl.obolibrary.org/obo/HP_0100158		
HP:0100159	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022262	hp.json	Cone-shaped end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100159		
HP:0100156	biolink:PhenotypicFeature	Triangular epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022265	hp.json	Triangular end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100156		
HP:0100157	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022264	hp.json	Absent end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100157		
HP:0100154	biolink:PhenotypicFeature	Small epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022267	hp.json	Small end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100154		
GO:0030103	biolink:NamedThing	vasopressin secretion			hp.json		http://purl.obolibrary.org/obo/GO_0030103		
HP:0100155	biolink:PhenotypicFeature	Stippling of the epiphysis of the middle phalanx of the 3rd toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 3rd toe.	UMLS:C4022266	hp.json	Speckled calcifications in the end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100155		
GO:0030104	biolink:NamedThing	water homeostasis			hp.json		http://purl.obolibrary.org/obo/GO_0030104		
HP:0100152	biolink:PhenotypicFeature	Ivory epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022269	hp.json	Increased bone density of end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100152		
HP:0100153	biolink:PhenotypicFeature	Pseudoepiphysis of the middle phalanx of the 3rd toe		UMLS:C4022268	hp.json		http://purl.obolibrary.org/obo/HP_0100153		
HP:0100150	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022271	hp.json	Fragmentation of the end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100150		
HP:0100151	biolink:PhenotypicFeature	Irregular epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022270	hp.json	Irregular end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100151		
OBO:chebi#is_conjugate_acid_of	biolink:NamedThing	is conjugate acid of			hp.json		http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of		
GO:0017148	biolink:BiologicalProcess	negative regulation of translation	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.		hp.json	downregulation of protein biosynthetic process|negative regulation of protein anabolism|down regulation of protein biosynthetic process|negative regulation of protein synthesis|inhibition of protein biosynthetic process|protein biosynthetic process inhibitor activity|negative regulation of protein biosynthesis|down-regulation of protein biosynthetic process|protein biosynthesis inhibitor activity|negative regulation of protein biosynthetic process|negative regulation of protein formation	http://purl.obolibrary.org/obo/GO_0017148		
GO:0017145	biolink:BiologicalProcess	stem cell division	The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types.		hp.json	stem cell renewal	http://purl.obolibrary.org/obo/GO_0017145		
HP:0100169	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the 4th toe		UMLS:C4022252	hp.json	Absent end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100169		
UBERON:0006919	biolink:AnatomicalEntity	tongue squamous epithelium	A squamous epithelium that is part of a tongue.	MA:0002786	hp.json	squamous epithelium of tongue	http://purl.obolibrary.org/obo/UBERON_0006919		pheno_slim
HP:0100167	biolink:PhenotypicFeature	Triangular epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022254	hp.json	Triangular end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100167		
HP:0100168	biolink:PhenotypicFeature	Fragmented epiphyses	Fragmented appearance of the epiphyses.	UMLS:C4022253	hp.json	Fragmented end part of bone	http://purl.obolibrary.org/obo/HP_0100168		
UBERON:0006916	biolink:AnatomicalEntity	non-keratinized epithelium of tongue	A non-keratinized stratified squamous epithelium that is part of a tongue.	FMA:62130	hp.json		http://purl.obolibrary.org/obo/UBERON_0006916		
UBERON:0006915	biolink:AnatomicalEntity	stratified squamous epithelium	Multilaminar epithelium which consists of more than one layer of squamous cells only one layer of which is in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, epithelium of wall of esophagus.[FMA].	Wikipedia:Stratified_squamous_epithelium|UMLS:C0836131|FMA:45563|NCIT:C13180	hp.json	epithelium stratificatum squamosum	http://purl.obolibrary.org/obo/UBERON_0006915		pheno_slim
HP:0100165	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022256	hp.json	Small end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100165		
UBERON:0006914	biolink:AnatomicalEntity	squamous epithelium	An epithelium characterised by its most superficial layer consisting of squamous epithelial cells.	BTO:0002072|Wikipedia:Squamous_epithelium|SCTID:40118003|NCIT:C12848|UMLS:C0221909	hp.json		http://purl.obolibrary.org/obo/UBERON_0006914		
HP:0100166	biolink:PhenotypicFeature	Stippling of the epiphysis of the proximal phalanx of the 3rd toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the proximal phalanx of the 3rd toe.	UMLS:C4022255	hp.json	Speckled calcifications in of the end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100166		
HP:0100163	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022258	hp.json	Increased bone density of end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100163		
HP:0100164	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the 3rd toe	A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the third toe.	UMLS:C4022257	hp.json		http://purl.obolibrary.org/obo/HP_0100164		
RO:0002134	biolink:NamedThing	innervates	Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.	RO:0002134	hp.json		http://purl.obolibrary.org/obo/RO_0002134		
HP:0100161	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022260	hp.json	Fragmentation of the end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100161		
GO:0042168	biolink:BiologicalProcess	heme metabolic process	The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.		hp.json	haem metabolic process|heme metabolism|haem metabolism	http://purl.obolibrary.org/obo/GO_0042168		
HP:0100162	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022259	hp.json	Irregular end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100162		
HP:0100160	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022261	hp.json	Enlarged end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100160		
RO:0002131	biolink:NamedThing	overlaps	x overlaps y if and only if there exists some z such that x has part z and z part of y	RO:0002131	hp.json		http://purl.obolibrary.org/obo/RO_0002131		ro-eco|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
UBERON:0006924	biolink:AnatomicalEntity	stomach glandular epithelium	A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands.	FMA:63458|EMAPA:35814|EMAPA:17623|MA:0002784	hp.json	gastric gland epithelium|epithelium of gastric gland	http://purl.obolibrary.org/obo/UBERON_0006924		pheno_slim
UBERON:0006923	biolink:AnatomicalEntity	vagina squamous epithelium	A squamous epithelium that is part of a vagina.	NCIT:C49314|EMAPA:37794|UMLS:C1711259|MA:0001731	hp.json	vaginal squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006923		
UBERON:0006922	biolink:AnatomicalEntity	cervix squamous epithelium	The squamous epithelium of the cervical portio is similar to that of the vagina, except that it is generally smooth and lacks rete pegs. Colposcopically, it appears featureless except for a fine network of vessels which is sometimes visible. The relative opacity and pale pink coloration of the squamous epithelium derives from its multi-layered histology and the location of its supporting vessels below the basement membrane.	UMLS:C1707351|MA:0001725|NCIT:C49219	hp.json	cervical squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006922		pheno_slim|human_reference_atlas
UBERON:0006921	biolink:AnatomicalEntity	stomach squamous epithelium	A squamous epithelium that is part of a stomach.	EMAPA:35824|MA:0001611	hp.json		http://purl.obolibrary.org/obo/UBERON_0006921		pheno_slim
UBERON:0006920	biolink:AnatomicalEntity	esophagus squamous epithelium	A squamous epithelium that is part of a esophagus.	BTO:0003635|NCIT:C49222|EMAPA:35324|MA:0001567|UMLS:C1707950|CALOHA:TS-1250	hp.json	squamous epithelium of esophagus|squamous oesophageal epithelium|esophageal squamous epithelium	http://purl.obolibrary.org/obo/UBERON_0006920		pheno_slim
UBERON:0006909	biolink:AnatomicalEntity	lumen of digestive tract	An anatomical space that surrounded_by a digestive tract.	BTO:0000349|FMA:45677|EMAPA:32908	hp.json	gut lumen|lumen of alimentary tract|digestive tract lumen|lumen of gut|lumen of digestive tract|lumen of alimentary tract|digestive tract lumen|gut cavity|lumen of digestive tract	http://purl.obolibrary.org/obo/UBERON_0006909		
UBERON:0006906	biolink:AnatomicalEntity	ala of nose	The lateral surface parts of the external nose, inferiorly, surrounding the naris[EoM].	FMA:59519	hp.json	wing of nose|wing of the nose|wings of the nose|ala nasi|nasal ala|ala nasi|ala of the nose	http://purl.obolibrary.org/obo/UBERON_0006906		pheno_slim
HP:0100178	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the 4th toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the 4th toe.	UMLS:C4022243	hp.json	Speckled calcifications in the end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100178		
UBERON:0006905	biolink:AnatomicalEntity	mandibular process mesenchyme	Mesenchyme that is part of a mandibular prominence.	EHDAA:5873|EHDAA:5861|EHDAA2:0001062|EMAPA:17357	hp.json	mesenchyme of mandibular process|mesenchyme of mandibular prominence|mesenchyme of mandibular prominence	http://purl.obolibrary.org/obo/UBERON_0006905		
HP:0100179	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the 4th toe		UMLS:C4022242	hp.json	Triangular end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100179		
UBERON:0006904	biolink:AnatomicalEntity	head mesenchyme from mesoderm	A head mesenchyme that develops_from a mesoderm.	VHOG:0000185|EHDAA2:0001118|EHDAA:655|EMAPA:16099|EFO:0003603|XAO:0000053|EFO:0003337|ZFA:0000998|AAO:0011051|EMAPA_RETIRED:16270|TAO:0000998|FMA:293859	hp.json	head mesenchyme from mesoderm|mesenchyme derived from head mesoderm|head mesenchyme derived from mesoderm|head mesenchyme from head mesoderm|head mesoderm|mesenchyme from head mesoderm|cranial mesoderm	http://purl.obolibrary.org/obo/UBERON_0006904		vertebrate_core|efo_slim
HP:0100176	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the 4th toe		UMLS:C4022245	hp.json		http://purl.obolibrary.org/obo/HP_0100176		
HP:0100177	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the 4th toe		UMLS:C4022244	hp.json	Small end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100177		
HP:0100174	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the 4th toe		UMLS:C4022247	hp.json	Irregular end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100174		
HP:0100175	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the 4th toe		UMLS:C4022246	hp.json	Increased bone density of end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100175		
HP:0100172	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the 4th toe		UMLS:C4022249	hp.json	Enlarged end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100172		
HP:0100173	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the 4th toe		UMLS:C4022248	hp.json	Fragmentation of the end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100173		
HP:0100170	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the 4th toe		UMLS:C4022251	hp.json	Bracket shaped end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100170		
HP:0100171	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the 4th toe		UMLS:C4022250	hp.json	Cone-shaped end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100171		
GO:0042175	biolink:CellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.		hp.json	nuclear envelope-endoplasmic reticulum continuum|NE-ER network|nuclear envelope-ER network|nuclear membrane-ER network|NE-ER continuum|nuclear envelope-endoplasmic reticulum network|nuclear membrane-endoplasmic reticulum continuum	http://purl.obolibrary.org/obo/GO_0042175		
GO:0017126	biolink:BiologicalProcess	nucleologenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells.		hp.json	nucleolus biogenesis|nucleolus assembly	http://purl.obolibrary.org/obo/GO_0017126		
UBERON:0006913	biolink:AnatomicalEntity	lip epithelium	An epithelium that is part of a lip.	ZFA:0005334|TAO:0005334|BTO:0004468	hp.json		http://purl.obolibrary.org/obo/UBERON_0006913		
GO:0042181	biolink:BiologicalProcess	ketone biosynthetic process	The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.		hp.json	ketone formation|ketone anabolism|ketone synthesis|ketone biosynthesis	http://purl.obolibrary.org/obo/GO_0042181		
GO:0042180	biolink:BiologicalProcess	cellular ketone metabolic process	The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.		hp.json	ketone metabolism	http://purl.obolibrary.org/obo/GO_0042180		goslim_pir
GO:0042182	biolink:BiologicalProcess	ketone catabolic process	The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.		hp.json	ketone breakdown|ketone catabolism|ketone degradation	http://purl.obolibrary.org/obo/GO_0042182		
HP:0100189	biolink:PhenotypicFeature	Stippling of the epiphysis of the middle phalanx of the 4th toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the middle phalanx of the 4th toe.	UMLS:C4022232	hp.json	Speckled calcifications in the end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100189		
HP:0100187	biolink:PhenotypicFeature	Pseudoepiphysis of the middle phalanx of the 4th toe	A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the middle phalanx of the fourth toe.	UMLS:C4022234	hp.json		http://purl.obolibrary.org/obo/HP_0100187		
HP:0100188	biolink:PhenotypicFeature	Small epiphysis of the middle phalanx of the 4th toe		UMLS:C4022233	hp.json	Small end part of middle long bone of 4th toe	http://purl.obolibrary.org/obo/HP_0100188		
HP:0100185	biolink:PhenotypicFeature	Irregular epiphysis of the middle phalanx of the 4th toe		UMLS:C4022236	hp.json	Irregular end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100185		
HP:0100186	biolink:PhenotypicFeature	Ivory epiphysis of the middle phalanx of the 4th toe		UMLS:C4022235	hp.json	Increased bone density of end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100186		
HP:0100183	biolink:PhenotypicFeature	Enlarged epiphysis of the middle phalanx of the 4th toe		UMLS:C4022238	hp.json	Enlarged end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100183		
HP:0100184	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the middle phalanx of the 4th toe		UMLS:C4022237	hp.json	Fragmentation of the end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100184		
HP:0100181	biolink:PhenotypicFeature	Bracket epiphysis of the middle phalanx of the 4th toe		UMLS:C4022240	hp.json	Bracket shaped end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100181		
HP:0100182	biolink:PhenotypicFeature	Cone-shaped epiphysis of the middle phalanx of the 4th toe		UMLS:C4022239	hp.json	Cone-shaped end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100182		
HP:0100180	biolink:PhenotypicFeature	Absent epiphysis of the middle phalanx of the 4th toe		UMLS:C4022241	hp.json	Absent end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100180		
RO:0002104	biolink:NamedThing	has plasma membrane part	Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.		hp.json		http://purl.obolibrary.org/obo/RO_0002104		
GO:0019755	biolink:BiologicalProcess	one-carbon compound transport	The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	one carbon compound transport	http://purl.obolibrary.org/obo/GO_0019755		
GO:0019752	biolink:BiologicalProcess	carboxylic acid metabolic process	The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).		hp.json	carboxylic acid metabolism	http://purl.obolibrary.org/obo/GO_0019752		
GO:0032722	biolink:BiologicalProcess	positive regulation of chemokine production	Any process that activates or increases the frequency, rate, or extent of chemokine production.		hp.json	positive regulation of chemokine biosynthetic process|upregulation of chemokine production|positive regulation of chemokine secretion|up regulation of chemokine production|stimulation of chemokine production|activation of chemokine production|up-regulation of chemokine production	http://purl.obolibrary.org/obo/GO_0032722		
HP:0100198	biolink:PhenotypicFeature	Pseudoepiphysis of the proximal phalanx of the 4th toe	A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the proximal phalanx of the fourth toe.	UMLS:C4022223	hp.json		http://purl.obolibrary.org/obo/HP_0100198		
GO:0005126	biolink:MolecularActivity	cytokine receptor binding	Binding to a cytokine receptor.		hp.json	hematopoietin/interferon-class (D200-domain) cytokine receptor ligand|hematopoietin/interferon-class (D200-domain) cytokine receptor binding	http://purl.obolibrary.org/obo/GO_0005126		
HP:0100199	biolink:PhenotypicFeature	Small epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022222	hp.json	Small end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100199		
HP:0100196	biolink:PhenotypicFeature	Irregular epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022225	hp.json	Irregular end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100196		
HP:0100197	biolink:PhenotypicFeature	Ivory epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022224	hp.json	Increased bone density of end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100197		
RO:0002100	biolink:NamedThing	has soma location	Relation between a neuron and an anatomical structure that its soma is part of.		hp.json		http://purl.obolibrary.org/obo/RO_0002100		
HP:0100194	biolink:PhenotypicFeature	Enlarged epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022227	hp.json	Enlarged end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100194		
HP:0100195	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022226	hp.json	Fragmentation of the end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100195		
HP:0100192	biolink:PhenotypicFeature	Bracket epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022229	hp.json	Bracket shaped end part of the innermost bone of 4th toe	http://purl.obolibrary.org/obo/HP_0100192		
HP:0100193	biolink:PhenotypicFeature	Cone-shaped epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022228	hp.json	Cone-shaped end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100193		
HP:0100190	biolink:PhenotypicFeature	Triangular epiphysis of the middle phalanx of the 4th toe		UMLS:C4022231	hp.json	Triangular end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100190		
HP:0100191	biolink:PhenotypicFeature	Absent epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022230	hp.json	Absent end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100191		
CHEBI:140601	biolink:ChemicalSubstance	fatty acid 4:0	Any saturated fatty acid containing 4 carbons.		hp.json		http://purl.obolibrary.org/obo/CHEBI_140601		3_STAR
CHEBI:59999	biolink:ChemicalSubstance	chemical substance	A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.		hp.json	Chemische Substanz	http://purl.obolibrary.org/obo/CHEBI_59999		3_STAR
NBO:0000339	biolink:NamedThing	motor coordination	"The coordination of combinations of body movements created with the kinematic (such as spatial direction) and kinetic (force) parameters that result in intended actions." [wikipedia:Motor_coordination]		hp.json		http://purl.obolibrary.org/obo/NBO_0000339		
NBO:0000338	biolink:NamedThing	kinesthetic behavior	"Movement behavior of the body or its parts."		hp.json		http://purl.obolibrary.org/obo/NBO_0000338		
GO:0044706	biolink:BiologicalProcess	multi-multicellular organism process	A multicellular organism process which involves another multicellular organism of the same or different species.		hp.json		http://purl.obolibrary.org/obo/GO_0044706		
GO:0044703	biolink:BiologicalProcess	multi-organism reproductive process	A biological process that directly contributes to the process of producing new individuals, involving another organism.		hp.json		http://purl.obolibrary.org/obo/GO_0044703		goslim_drosophila
NBO:0000347	biolink:NamedThing	gross motor coordination	"The coordination of large muscle groups and whole body movement." [NBO:GVG]		hp.json	whole body coordination|large muscle coordination	http://purl.obolibrary.org/obo/NBO_0000347		
NBO:0000355	biolink:NamedThing	posture	"Intentionally or habitually assumed arrangement of the body and its limbs." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000355		
NBO:0000317	biolink:NamedThing	vestibular behavior	"Behavior related to the awareness of body balance and movement." [MBP:GVG]		hp.json	proprioception	http://purl.obolibrary.org/obo/NBO_0000317		
NBO:0000313	biolink:NamedThing	behavior process	"The action, reaction, or performance of an organism in response to external or internal stimuli." [GO:GO\:0007610]		hp.json	behavior|behaviour	http://purl.obolibrary.org/obo/NBO_0000313		
GO:0030193	biolink:BiologicalProcess	regulation of blood coagulation	Any process that modulates the frequency, rate or extent of blood coagulation.		hp.json		http://purl.obolibrary.org/obo/GO_0030193		
HP:0004499	biolink:PhenotypicFeature	Chronic rhinitis due to narrow nasal airway		UMLS:C4025318	hp.json	Chronic nasal inflammation due to narrow nasal airway	http://purl.obolibrary.org/obo/HP_0004499		
HP:0004493	biolink:PhenotypicFeature	Craniofacial hyperostosis	Excessive growth of the craniofacial bones.	UMLS:C4280518|UMLS:C4280517|UMLS:C4280516|UMLS:C1868085	hp.json	Excessive growth of craniofacial bones|Enlargement of craniofacial bones|Hyperostosis of craniofacial bones|Excessive bone growth of the skull and face|Hypertrophy of craniofacial bones|Overgrowth of craniofacial bones|Increased ossification of craniofacial bones|Thick craniofacial bones	http://purl.obolibrary.org/obo/HP_0004493		hposlim_core
HP:0004492	biolink:PhenotypicFeature	Widely patent fontanelles and sutures	An abnormally increased width of the cranial fontanelles and sutures.	UMLS:C1849300	hp.json	Widely patent fontanels and sutures	http://purl.obolibrary.org/obo/HP_0004492		
GO:0030198	biolink:BiologicalProcess	extracellular matrix organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.		hp.json	extracellular matrix organization and biogenesis|extracellular matrix organisation	http://purl.obolibrary.org/obo/GO_0030198		goslim_generic|goslim_drosophila|goslim_chembl
HP:0004491	biolink:PhenotypicFeature	Large posterior fontanelle	An enlargement of the posterior fontanelle relative to age-dependent norms.	UMLS:C1855233	hp.json	Large posterior fontanel	http://purl.obolibrary.org/obo/HP_0004491		
HP:0004490	biolink:PhenotypicFeature	Calvarial hyperostosis	Excessive growth of the calvaria.	UMLS:C1863351|UMLS:C4280519|MSH:C537963|UMLS:C4280520	hp.json	Thick calvarial bones|Overgrowth of calvarial bones|Hypertrophy of calvarial bones|Overgrowth of skullcap|Enlargement of calvarial bones|Increased ossification of calvarial bones|Excessive growth of calvarial bones|Hyperostosis of calvarial bones	http://purl.obolibrary.org/obo/HP_0004490		
GO:0030199	biolink:BiologicalProcess	collagen fibril organization	Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.		hp.json	collagen fibril organisation|fibrillar collagen organization	http://purl.obolibrary.org/obo/GO_0030199		
HP:0004496	biolink:PhenotypicFeature	obsolete Posterior choanal atresia			hp.json		http://purl.obolibrary.org/obo/HP_0004496		
GO:0030194	biolink:BiologicalProcess	positive regulation of blood coagulation	Any process that activates or increases the frequency, rate or extent of blood coagulation.		hp.json	up regulation of blood coagulation|activation of blood coagulation|stimulation of blood coagulation|upregulation of blood coagulation|up-regulation of blood coagulation	http://purl.obolibrary.org/obo/GO_0030194		
HP:0004495	biolink:PhenotypicFeature	Thin anteverted nares		UMLS:C1834056	hp.json		http://purl.obolibrary.org/obo/HP_0004495		
GO:0030195	biolink:BiologicalProcess	negative regulation of blood coagulation	Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.		hp.json	down-regulation of blood coagulation|down regulation of blood coagulation|downregulation of blood coagulation|inhibition of blood coagulation	http://purl.obolibrary.org/obo/GO_0030195		
NBO:0000327	biolink:NamedThing	somatic sensation related behavior	"Behavior related to the sensations arising from the skin and from the muscles, tendons, and joints." [OBP:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000327		
GO:0030182	biolink:BiologicalProcess	neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron.		hp.json		http://purl.obolibrary.org/obo/GO_0030182		
GO:0030187	biolink:NamedThing	melatonin biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0030187		
GO:0030186	biolink:NamedThing	melatonin metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0030186		
GO:0030183	biolink:BiologicalProcess	B cell differentiation	The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.		hp.json	B-lymphocyte differentiation|B cell development|B-cell differentiation|B lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_0030183		
CHEBI:84981	biolink:ChemicalSubstance	2-aminoadipate(2-)	A dicarboxylic acid dianion that is the conjugate base of 2-aminoadipic acid.		hp.json	2-aminohexanedioate|alpha-aminoadipate	http://purl.obolibrary.org/obo/CHEBI_84981		3_STAR
NBO:0000388	biolink:NamedThing	involuntary movement behavior	"Behavior related to movements that occur independent of planning." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000388		
NBO:0000389	biolink:NamedThing	reflexive behavior	"Behavior related to involuntary movement in response to a stimulus." [NBO:GVG]		hp.json	reflex behaviour	http://purl.obolibrary.org/obo/NBO_0000389		
GO:0030168	biolink:BiologicalProcess	platelet activation	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.		hp.json	blood coagulation, platelet activation	http://purl.obolibrary.org/obo/GO_0030168		
HP:0100105	biolink:PhenotypicFeature	Irregular epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022316	hp.json	Irregular end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100105		
HP:0100106	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022315	hp.json	Increased bone density of end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100106		
HP:0100103	biolink:PhenotypicFeature	Enlarged epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022318	hp.json	Enlarged end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100103		
HP:0100104	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022317	hp.json	Fragmentation of the end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100104		
HP:0100101	biolink:PhenotypicFeature	Bracket epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022320	hp.json	Bracket shaped end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100101		
HP:0100102	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022319	hp.json	Cone-shaped end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100102		
HP:0100100	biolink:PhenotypicFeature	Absent epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022321	hp.json	Absent end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100100		
GO:0042100	biolink:BiologicalProcess	B cell proliferation	The expansion of a B cell population by cell division. Follows B cell activation.		hp.json	B-cell proliferation|B lymphocyte proliferation|B-lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0042100		
GO:0042103	biolink:BiologicalProcess	positive regulation of T cell homeostatic proliferation	Any process that activates or increases the rate or extent of resting T cell proliferation.		hp.json	up-regulation of T cell homeostatic proliferation|activation of T cell homeostatic proliferation|positive regulation of T-lymphocyte homeostatic proliferation|upregulation of T cell homeostatic proliferation|positive regulation of resting T cell proliferation|up regulation of T cell homeostatic proliferation|positive regulation of T-cell homeostatic proliferation|stimulation of T cell homeostatic proliferation|positive regulation of T lymphocyte homeostatic proliferation	http://purl.obolibrary.org/obo/GO_0042103		
GO:0042102	biolink:BiologicalProcess	positive regulation of T cell proliferation	Any process that activates or increases the rate or extent of T cell proliferation.		hp.json	positive regulation of T-lymphocyte proliferation|upregulation of T cell proliferation|stimulation of T cell proliferation|up regulation of T cell proliferation|positive regulation of T lymphocyte proliferation|activation of T cell proliferation|up-regulation of T cell proliferation	http://purl.obolibrary.org/obo/GO_0042102		
GO:0030154	biolink:BiologicalProcess	cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.	Wikipedia:Cellular_differentiation	hp.json		http://purl.obolibrary.org/obo/GO_0030154		goslim_drosophila|goslim_chembl|goslim_mouse|goslim_agr|goslim_generic|goslim_plant
GO:0030155	biolink:BiologicalProcess	regulation of cell adhesion	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.		hp.json	cell adhesion receptor regulator activity	http://purl.obolibrary.org/obo/GO_0030155		
HP:0100109	biolink:PhenotypicFeature	Stippling of the epiphysis of the distal phalanx of the 2nd toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the distal phalanx of the 2nd toe.	UMLS:C4022312	hp.json	Speckled calcifications in the end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100109		
HP:0100107	biolink:PhenotypicFeature	Pseudoepiphysis of the distal phalanx of the 2nd toe		UMLS:C4022314	hp.json		http://purl.obolibrary.org/obo/HP_0100107		
HP:0100108	biolink:PhenotypicFeature	Small epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022313	hp.json	Small end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100108		
HP:0100116	biolink:PhenotypicFeature	Irregular epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022305	hp.json	Irregular end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100116		
HP:0100117	biolink:PhenotypicFeature	Ivory epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022304	hp.json	Increased bone density of end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100117		
HP:0100114	biolink:PhenotypicFeature	Enlarged epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022307	hp.json	Enlarged end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100114		
HP:0100115	biolink:PhenotypicFeature	Fragmentation of the epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022306	hp.json	Fragmentation of the end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100115		
HP:0100112	biolink:PhenotypicFeature	Bracket epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022309	hp.json	Bracket shaped end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100112		
HP:0100113	biolink:PhenotypicFeature	Cone-shaped epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022308	hp.json	Cone-shaped end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100113		
HP:0100110	biolink:PhenotypicFeature	Triangular epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022311	hp.json	Triangular end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100110		
HP:0100111	biolink:PhenotypicFeature	Absent epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022310	hp.json	Absent end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100111		
GO:0042113	biolink:BiologicalProcess	B cell activation	The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.		hp.json	B lymphocyte activation|B-cell activation|B-lymphocyte activation	http://purl.obolibrary.org/obo/GO_0042113		
GO:0042110	biolink:BiologicalProcess	T cell activation	The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.		hp.json	T-lymphocyte activation|T lymphocyte activation|T-cell activation	http://purl.obolibrary.org/obo/GO_0042110		
GO:0042119	biolink:BiologicalProcess	neutrophil activation	The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.		hp.json		http://purl.obolibrary.org/obo/GO_0042119		
GO:0042116	biolink:BiologicalProcess	macrophage activation	A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.		hp.json	macrophage polarization	http://purl.obolibrary.org/obo/GO_0042116		
GO:0042118	biolink:BiologicalProcess	endothelial cell activation	The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.		hp.json		http://purl.obolibrary.org/obo/GO_0042118		
GO:0042117	biolink:BiologicalProcess	monocyte activation	The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.		hp.json		http://purl.obolibrary.org/obo/GO_0042117		
GO:0030141	biolink:CellularComponent	secretory granule	A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.		hp.json	secretory vesicle	http://purl.obolibrary.org/obo/GO_0030141		
HP:0100118	biolink:PhenotypicFeature	Pseudoepiphysis of the middle phalanx of the 2nd toe	A pseudoepiphysis (an accessory epiphysis that does not significantly contribute to the longitudinal growth of a tubular bone) located in the middle phalanx of the second toe.	UMLS:C4022303	hp.json		http://purl.obolibrary.org/obo/HP_0100118		
HP:0100119	biolink:PhenotypicFeature	Small epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022302	hp.json	Small end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100119		
CHEBI:59905	biolink:ChemicalSubstance	dopaminium(1+)	An ammonium ion that is the conjugate acid of dopamine; major species at pH 7.3.	Gmelin:328863	hp.json	dopaminium cation|2-(3,4-dihydroxyphenyl)ethan-1-aminium|2-(3,4-dihydroxyphenyl)ethanaminium|dopamine	http://purl.obolibrary.org/obo/CHEBI_59905		3_STAR
UBERON:0004385	biolink:AnatomicalEntity	epiphysis of radius	An epiphysis that is part of a radius [Automatically generated definition].	FMA:33770	hp.json	radial epiphysis	http://purl.obolibrary.org/obo/UBERON_0004385		pheno_slim
UBERON:0004386	biolink:AnatomicalEntity	epiphysis of ulna	An epiphysis that is part of an ulna [Automatically generated definition].	FMA:33748	hp.json	ulnar epiphysis	http://purl.obolibrary.org/obo/UBERON_0004386		pheno_slim
HP:0004434	biolink:PhenotypicFeature	Decreased serum complement C8	A reduced level of the complement component C8 in circulation.	UMLS:C3151082	hp.json	C8 deficiency	http://purl.obolibrary.org/obo/HP_0004434		
UBERON:0004383	biolink:AnatomicalEntity	epiphysis of tibia	An epiphysis that is part of a tibia [Automatically generated definition].	EMAPA:37771|FMA:33112|MA:0003113	hp.json	tibial epiphysis	http://purl.obolibrary.org/obo/UBERON_0004383		pheno_slim
HP:0004433	biolink:PhenotypicFeature	Secretory IgA deficiency	Deficiency of secretory IgA (polymers of 2-4 IgA monomers are linked by two additional chains) and is the primary antibody response at the mucosal level, where it forms immune complexes with pathogens and allergens.	SNOMEDCT_US:234554004|UMLS:C0398709|MSH:C562869	hp.json		http://purl.obolibrary.org/obo/HP_0004433		
HP:0004432	biolink:PhenotypicFeature	Agammaglobulinemia	A lasting absence of total IgG and total IgA and total IgM in the blood circulation, whereby at most trace quantities can be measured.	UMLS:C0001768|SNOMEDCT_US:119249001|MSH:D000361	hp.json	Agammaglobulinaemia	http://purl.obolibrary.org/obo/HP_0004432		
UBERON:0004384	biolink:AnatomicalEntity	epiphysis of femur	An epiphysis that is part of a femur [Automatically generated definition].	EMAPA:37539|FMA:32838|MA:0003056	hp.json	femoral epiphysis	http://purl.obolibrary.org/obo/UBERON_0004384		pheno_slim
UBERON:0004381	biolink:AnatomicalEntity	skeleton of limb	The collection of all skeletal elements in an individual limb.	VSAO:0000300|EMAPA:32702|EHDAA2:0002221	hp.json	free limb skeleton|set of bones of limb|limb skeleton	http://purl.obolibrary.org/obo/UBERON_0004381		
CHEBI:35931	biolink:ChemicalSubstance	delta-amino acid	A non-proteinogenic amino acid in which the amino group is located on the carbon atom at the position delta to the carboxy group.		hp.json	delta-amino acids	http://purl.obolibrary.org/obo/CHEBI_35931		3_STAR
HP:0004439	biolink:PhenotypicFeature	Craniofacial dysostosis	A characteristic appearance resulting from defective ossification of craniofacial bones.	SNOMEDCT_US:28861008|UMLS:C0010273|MSH:D003394	hp.json	Crouzon syndrome	http://purl.obolibrary.org/obo/HP_0004439		
UBERON:0004382	biolink:AnatomicalEntity	epiphysis of humerus	An epiphysis that is part of a humerus [Automatically generated definition].	FMA:32825	hp.json	humeral epiphysis	http://purl.obolibrary.org/obo/UBERON_0004382		pheno_slim
HP:0004438	biolink:PhenotypicFeature	Hyperostosis frontalis interna	Bony overgrowth of the internal (endosteal) surface of the frontal bone.	MSH:D006957|UMLS:C4280527|UMLS:C4280526|UMLS:C4280525|UMLS:C4280524|UMLS:C0020494|SNOMEDCT_US:82054006	hp.json	Thick inner surface of the frontal bone|Hypertrophy of the internal surface of the frontal bone|Thick internal surface of the frontal bone|Overgrowth of the inner surface of the frontal bone|Enlargement of the inner surface of the frontal bone|Excessive growth of inner surface of the frontal bone|Increased ossification of the internal surface of the frontal bone|Overgrowth of the inside of the frontal bone|Hyperostosis of the internal surface of the frontal bone	http://purl.obolibrary.org/obo/HP_0004438		
HP:0004437	biolink:PhenotypicFeature	Cranial hyperostosis	Excessive growth of the bones of cranium, i.e., of the skull.	UMLS:C1832451|UMLS:C4280529|UMLS:C4280528|UMLS:C4280531|UMLS:C4280530	hp.json	Overgrowth of skull bones|Hypertrophy of cranial bones|Hyperostosis of cranial vault|Enlargement of skull bones|Excessive growth of skull bones|Increased ossification of cranial bones|Hyperostosis of cranial bones|Thick skull bones	http://purl.obolibrary.org/obo/HP_0004437		
UBERON:0004380	biolink:AnatomicalEntity	proximal epiphysis	An epiphysis that is on the proximal side of the bone.	FMA:32821	hp.json	proximal end of long bone	http://purl.obolibrary.org/obo/UBERON_0004380		
UBERON:0004389	biolink:AnatomicalEntity	epiphysis of metatarsal bone	An epiphysis that is part of a metatarsal bone [Automatically generated definition].	FMA:33814	hp.json	metatarsal epiphysis|metatarsal bone epiphysis|epiphysis of metatarsal	http://purl.obolibrary.org/obo/UBERON_0004389		pheno_slim
HP:0004431	biolink:PhenotypicFeature	Complement deficiency	An immunodeficiency defined by the absent or suboptimal functioning of one of the complement system proteins.	UMLS:C0272242|SNOMEDCT_US:24743004	hp.json		http://purl.obolibrary.org/obo/HP_0004431		
HP:0004430	biolink:PhenotypicFeature	Severe combined immunodeficiency	A type of primary immune deficiency that is characterized by a more severe defect in both the T- and B-lymphocyte systems.	SNOMEDCT_US:31323000|MSH:D016511|UMLS:C0085110	hp.json	Immunodeficiency, severe combined	http://purl.obolibrary.org/obo/HP_0004430		
UBERON:0004387	biolink:AnatomicalEntity	epiphysis of phalanx of manus	An epiphysis that is part of a phalanx of a manus [Automatically generated definition].	FMA:240707	hp.json	epiphysis of phalanx of finger|epiphysis of phalanx of hand	http://purl.obolibrary.org/obo/UBERON_0004387		pheno_slim
UBERON:0004388	biolink:AnatomicalEntity	epiphysis of fibula	An epiphysis that is part of a fibula [Automatically generated definition].	FMA:33726	hp.json	fibula epiphysis	http://purl.obolibrary.org/obo/UBERON_0004388		pheno_slim
CHEBI:23965	biolink:ChemicalSubstance	estradiol	A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17.	PMID:10696569|Wikipedia:Estradiol|PMID:24084694	hp.json	oestradiol|estra-1,3,5(10)-triene-3,17-diol	http://purl.obolibrary.org/obo/CHEBI_23965		3_STAR
CHEBI:11955	biolink:ChemicalSubstance	4-amino-3-hydroxybutanoate	The conjugate base of gamma-amino-beta-hydroxybutyric acid arising from deprotonation of the carboxy group.	KEGG:C03678|CAS:352-21-6	hp.json	4-Amino-3-hydroxybutanoate	http://purl.obolibrary.org/obo/CHEBI_11955		3_STAR
UBERON:0004374	biolink:AnatomicalEntity	vitelline vasculature	Vascular network that is connected to the yolk sac.	Wikipedia:Vitelline_circulation	hp.json	omphalomesenteric system|vitelline system|vitelline bloos vessel system|vitelline system|omphalomesenteric system|vitelline bloos vessel system	http://purl.obolibrary.org/obo/UBERON_0004374		pheno_slim
HP:0004446	biolink:PhenotypicFeature	Stomatocytosis	The presence of erythrocytes with a mouth-shaped (stoma) area of central pallor on peripheral blood smear.	UMLS:C0677598	hp.json	Red cell stomatocytosis|erythrocyte stomatocytes	http://purl.obolibrary.org/obo/HP_0004446		
UBERON:0004375	biolink:AnatomicalEntity	bone of free limb or fin	A bone that is part of an appendage [Automatically generated definition].		hp.json	bone of appendage|appendage bone|bone of free segment of appendicular skeleton	http://purl.obolibrary.org/obo/UBERON_0004375		homology_grouping
HP:0004445	biolink:PhenotypicFeature	Elliptocytosis	The presence of elliptical, cigar-shaped erythrocytes on peripheral blood smear.	MSH:D004612|SNOMEDCT_US:250242004|UMLS:C0427480|SNOMEDCT_US:178935009|SNOMEDCT_US:191169008|UMLS:C0013902	hp.json	Ovalocytosis|Ovalocytes|Elliptocyte|Hereditary elliptocytosis	http://purl.obolibrary.org/obo/HP_0004445		
HP:0004444	biolink:PhenotypicFeature	Spherocytosis	The presence of erythrocytes that are sphere-shaped.	UMLS:C0553720|SNOMEDCT_US:17235000	hp.json		http://purl.obolibrary.org/obo/HP_0004444		
HP:0004443	biolink:PhenotypicFeature	Lambdoidal craniosynostosis	A kind of craniosynostosis affecting the lambdoidal suture.	MSH:D003398|UMLS:C1833340|SNOMEDCT_US:109417006	hp.json	Lambdoid suture synostosis|Lambdoid suture craniosynostosis	http://purl.obolibrary.org/obo/HP_0004443		hposlim_core
UBERON:0004370	biolink:AnatomicalEntity	anterior limiting lamina of cornea	A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane.	SCTID:281075003|NCIT:C32226|ZFA:0001684|UMLS:C0229127|FMA:58273|MA:0001240|TAO:0002155|Wikipedia:Bowman%27s_membrane	hp.json	anterior limiting membrane|Bowman's layer|lamina limitans anterior (cornea)|anterior limiting lamina|lamina limitans anterior corneae|Reichert's membrane|Bowman's membrane|anterior elastic lamina|Bowman's anterior elastic lamina|Reichert's membrane|anterior limiting lamina of cornea	http://purl.obolibrary.org/obo/UBERON_0004370		vertebrate_core|pheno_slim
CHEBI:35942	biolink:ChemicalSubstance	neurotransmitter agent	A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.		hp.json	neurotransmitter agents	http://purl.obolibrary.org/obo/CHEBI_35942		3_STAR
CHEBI:60911	biolink:ChemicalSubstance	racemate	A racemate is an equimolar mixture of a pair of enantiomers.		hp.json	melange racemique|racemates|racemic mixture	http://purl.obolibrary.org/obo/CHEBI_60911		3_STAR
HP:0004448	biolink:PhenotypicFeature	Fulminant hepatic failure	Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as fulminant if there is onset of encephalopathy within 4 weeks of the onset of symptoms in a patient with a previously healthy liver.	MSH:D017114|SNOMEDCT_US:197270009|SNOMEDCT_US:235884008|UMLS:C0162557	hp.json		http://purl.obolibrary.org/obo/HP_0004448		
HP:0004447	biolink:PhenotypicFeature	Poikilocytosis	The presence of abnormally shaped erythrocytes.	SNOMEDCT_US:165479004|UMLS:C0221281	hp.json		http://purl.obolibrary.org/obo/HP_0004447		
CHEBI:23966	biolink:ChemicalSubstance	estrane		Beilstein:3125721|LIPID_MAPS_instance:LMST02010000	hp.json	Oestran|oestrane|estrane	http://purl.obolibrary.org/obo/CHEBI_23966		3_STAR
HP:0004442	biolink:PhenotypicFeature	Sagittal craniosynostosis	A kind of craniosynostosis affecting the sagittal suture.	SNOMEDCT_US:109418001|UMLS:C0432123	hp.json	Craniosynostosis, sagittal suture|Craniosynostosis, sagittal|Early closure of midline skull joint|Sagittal suture synostosis|Midline skull joint closes early	http://purl.obolibrary.org/obo/HP_0004442		hposlim_core
UBERON:0004378	biolink:AnatomicalEntity	proximal metaphysis	A metaphysis that is in the proximal side of a diaphysis.	FMA:32823	hp.json	proximal diaphyseal end of long bone	http://purl.obolibrary.org/obo/UBERON_0004378		
UBERON:0004379	biolink:AnatomicalEntity	distal epiphysis	An epiphysis that is on the distal side of the bone.	FMA:32822	hp.json	distal end of long bone	http://purl.obolibrary.org/obo/UBERON_0004379		
HP:0004440	biolink:PhenotypicFeature	Coronal craniosynostosis	Premature closure of the coronal suture of skull.	UMLS:C1856266	hp.json	Coronal suture craniosynostosis|Coronal suture synostosis|Craniosynostosis of coronal suture	http://purl.obolibrary.org/obo/HP_0004440		hposlim_core
UBERON:0004377	biolink:AnatomicalEntity	distal metaphysis	A metaphysis that is in the distal side of a diaphysis.	FMA:32824	hp.json	distal diaphyseal end of long bone	http://purl.obolibrary.org/obo/UBERON_0004377		
HP:0004419	biolink:PhenotypicFeature	Recurrent thrombophlebitis	Repeated episodes of inflammation of a vein associated with venous thrombosis (blood clot formation within the vein).	UMLS:C3550150	hp.json	Recurrent thrombosis|Recurrent phlebitis	http://purl.obolibrary.org/obo/HP_0004419		
CHEBI:35915	biolink:ChemicalSubstance	sterol ester	A steroid ester obtained by formal condensation of the carboxy group of any carboxylic acid with the 3-hydroxy group of a sterol.	KEGG:C01958	hp.json	a sterol ester|3-hydroxysteroid esters|Steryl ester|Sterol ester|3-hydroxysteroid ester	http://purl.obolibrary.org/obo/CHEBI_35915		3_STAR
HP:0004418	biolink:PhenotypicFeature	Thrombophlebitis	Inflammation of a vein associated with venous thrombosis (blood clot formation within the vein).	MSH:D013924|SNOMEDCT_US:64156001|UMLS:C0040046	hp.json		http://purl.obolibrary.org/obo/HP_0004418		
UBERON:0004363	biolink:AnatomicalEntity	pharyngeal arch artery	One of a series of paired embryological vascular structures formed within a pharyngeal arch; in the adult, some of these vessels give rise to the great vessels[MP].	TAO:0005004|Wikipedia:Aortic_arches|EHDAA2:0000186|EFO:0003695|UMLS:C0003489|VHOG:0000122|AAO:0010414|EMAPA:16684|XAO:0000341|EHDAA:7327|NCIT:C32123|ZFA:0005004|EHDAA:398	hp.json	branchial arch artery|arteriae arcuum pharyngeorum|a. arcuum pharyngeorum|pharyngeal arch artery|aortic arches|aortic arch|pharyngeal arch artery|embryonic aortic arch artery|branchial aortic arches|PAA|arteriae arcuum pharyngeorum|branchial aortic arches|a. arcuum pharyngeorum|aortic arch artery|pharyngeal arch arteries	http://purl.obolibrary.org/obo/UBERON_0004363		pheno_slim|efo_slim|uberon_slim|vertebrate_core
HP:0004411	biolink:PhenotypicFeature	Deviated nasal septum	Positioning of the nasal septum to the right or left in contrast to the normal midline position of the nasal septum.	UMLS:C0549397|SNOMEDCT_US:126660000	hp.json	Deviated nasal septum|Crooked nasal septum|Deviated septum of nose|Crooked septum of nose	http://purl.obolibrary.org/obo/HP_0004411		hposlim_core
UBERON:0004362	biolink:AnatomicalEntity	pharyngeal arch 1	The first of the series of pharyngeal arches that develop into jaw bones or their homologs, and their associated nerves and arteries.	TAO:0001595|EHDAA:573|AAO:0010364|NCIT:C34175|UMLS:C1517197|EMAPA:16118|ZFA:0001612|SCTID:308767008|VHOG:0000296|CALOHA:TS-2089|MFMO:0000095|EHDAA2:0000006|Wikipedia:First_pharyngeal_arch|FMA:293019|XAO:0000097	hp.json	arcus pharyngeus primus|branchial arch 1|1st arch|first branchial arch|1st pharyngeal arch|first pharyngeal arch|arcus pharyngeus primus|visceral arch 1|1st visceral arch|mandibular arch|first visceral arch	http://purl.obolibrary.org/obo/UBERON_0004362		pheno_slim|uberon_slim|vertebrate_core
HP:0004417	biolink:PhenotypicFeature	Intermittent claudication	Intermittent claudication is a symptom of peripheral arterial occlusive disease. After having walked over a distance which is individually characteristic, the patients experience pain or cramps in the calves, feet or thighs which typically subsides on standing still.	MSH:D007383|UMLS:C0021775|SNOMEDCT_US:63491006	hp.json		http://purl.obolibrary.org/obo/HP_0004417		
HP:0004416	biolink:PhenotypicFeature	Precocious atherosclerosis		UMLS:C4021654|UMLS:C4280264	hp.json	Premature atherosclerosis|Premature plaque build-up in arteries	http://purl.obolibrary.org/obo/HP_0004416		
HP:0004415	biolink:PhenotypicFeature	Pulmonary artery stenosis	An abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches.	UMLS:C0238397|SNOMEDCT_US:95441000|MSH:D000071079|Fyler:1622	hp.json	Narrowing of lung artery	http://purl.obolibrary.org/obo/HP_0004415		
CHEBI:35910	biolink:ChemicalSubstance	2-oxo monocarboxylic acid	Any monocarboxylic acid having a 2-oxo substituent.	KEGG:C00161	hp.json	2-Oxo acid|2-Oxocarboxylate|2-oxo monocarboxylic acids|2-oxo acid|2-oxo carboxylic acids	http://purl.obolibrary.org/obo/CHEBI_35910		3_STAR
HP:0004414	biolink:PhenotypicFeature	Abnormality of the pulmonary artery	An abnormality of the pulmonary artery.	SNOMEDCT_US:128588008|SNOMEDCT_US:198914002|UMLS:C0009681|SNOMEDCT_US:36110001	hp.json	Abnormality of lung artery	http://purl.obolibrary.org/obo/HP_0004414		
CHEBI:60924	biolink:ChemicalSubstance	keratan sulfate	A sulfated glycosaminoglycan, a linear polymer that consists of the repeating disaccharide  [3)-beta-Gal-(1->4)-beta-GlcNAc-(1->] and containing sulfo groups located at random positions.		hp.json	keratosulfate|keratan sulfates	http://purl.obolibrary.org/obo/CHEBI_60924		3_STAR
UBERON:0004367	biolink:AnatomicalEntity	Descemet's membrane	A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].	MESH:D003886|FMA:58309|TAO:0002157|EMAPA:18804|SCTID:281076002|ZFA:0001686|GAID:894|Wikipedia:Descemet%27s_membrane|MA:0001246|UMLS:C0011665|NCIT:C32454	hp.json	Descemet membrane|lamina limitans posterior corneae|Descemet's posterior elastic lamina|posterior limiting lamina of cornea|posterior limiting lamina|lamina limitans posterior|posterior limiting membrane	http://purl.obolibrary.org/obo/UBERON_0004367		pheno_slim|vertebrate_core
UBERON:0004368	biolink:AnatomicalEntity	Reichert's cartilage	A continuous cartilaginous formation in mesenchyme of the second pharyngeal arch in the embryo. The longer cranial or styloid segment is continuous with the otic capsule; its inferior end is angulated and is situated very close to the oropharynx. The smaller caudal segment is in contact with the body and greater horn of the hyoid cartilaginous structure.	FMA:295800|EHDAA2:0000793|EMAPA:17622	hp.json	second branchial arch cartilage|hyaloid cartilage|Reichert cartilage|hyoid cartilage|second pharyngeal arch cartilage	http://purl.obolibrary.org/obo/UBERON_0004368		pheno_slim
UBERON:0004365	biolink:AnatomicalEntity	vitelline blood vessel	Blood vessel that is connected to the yolk sac.	EMAPA:36494	hp.json		http://purl.obolibrary.org/obo/UBERON_0004365		pheno_slim
CHEBI:47909	biolink:ChemicalSubstance	3-oxo-Delta(4) steroid	A 3-oxo steroid conjugated to a C=C double bond at the alpha,beta position.	KEGG:C00619|MetaCyc:3-Oxo-Delta-4-Steroids	hp.json	3-oxo-Delta(4) steroids|3-oxo Delta(4)-steroids|3-oxo Delta(4)-steroid|a 3-oxo-Delta(4)-steroid|3-Oxo-delta4-steroid	http://purl.obolibrary.org/obo/CHEBI_47909		3_STAR
HGNC:5389	biolink:Gene	IDS (human)	A protein coding gene IDS in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5389		
HP:0004429	biolink:PhenotypicFeature	Recurrent viral infections	Increased susceptibility to viral infections, as manifested by recurrent episodes of viral infection.	UMLS:C1837066	hp.json		http://purl.obolibrary.org/obo/HP_0004429		
HP:0004423	biolink:PhenotypicFeature	Cranium bifidum occultum	Cranium bifidum occultum, also known as Catlin mark, is a congenital midline skull defect presenting as an enlarged posterior fontanelle in the upper posterior angle of the parietal bone close to the intersection of the sagittal and lambdoid sutures.1, 2, 3 Cranium bifidum occultum occurs due to a defect in intramembranous ossification, a process through which skull bones (frontal, parietal, squamous temporal and occipital bones superior to the mendosal suture) ossify under a vascularized membrane toward the midline to cover the brain.1, 4, 5 Unlike cranium bifidum cysticum, cranium bifidum occultum does not have herniation of intracranial contents. As the skull grows, the midline cranium bifidum occultum defect is separated into bilateral enlarged parietal foramina (EPF) by a midline osseous bridge.	UMLS:C1868598|MSH:C566826|SNOMEDCT_US:718099006	hp.json		http://purl.obolibrary.org/obo/HP_0004423		
UBERON:0004353	biolink:AnatomicalEntity	female inguinal canal	An inguinal canal that is part of a female organism. Conveys the round ligament + the ilioinguinal nerve.[WP,unvetted].	EMAPA:19171|MA:0003249	hp.json	inguinal canal of female	http://purl.obolibrary.org/obo/UBERON_0004353		pheno_slim
HP:0004422	biolink:PhenotypicFeature	Biparietal narrowing	A narrowing of the biparietal diameter (i.e., of the transverse distance between the protuberances of the two parietal bones of the skull).	UMLS:C1854418|UMLS:C4280532	hp.json	Decreased width of the skull	http://purl.obolibrary.org/obo/HP_0004422		
HP:0004421	biolink:PhenotypicFeature	Elevated systolic blood pressure	Abnormal increase in systolic blood pressure.	UMLS:C1840374	hp.json	Elevated systolic BP	http://purl.obolibrary.org/obo/HP_0004421		
HP:0004428	biolink:PhenotypicFeature	Elfin facies	This is a description previously used to describe a facial form characterized by a short, upturned nose, wide mouth, widely spaced eyes, and full cheeks. Because of the imprecision in this definition it is preferable to describe these features precisely. This term is retained because it was often used in the past, but it should not be used for new annotations.	UMLS:C0332606|SNOMEDCT_US:69288002	hp.json	Elf-like facial appearance|Elf-like facial features|Leprechaun facies	http://purl.obolibrary.org/obo/HP_0004428		hposlim_core
HP:0004426	biolink:PhenotypicFeature	Abnormal cheek morphology	An abnormality of the cheek- one of two bilateral soft tissue facial structures in the region of the face inferior to the eyes and between the nose and the ear. "Buccal" means relating to the cheek. The cheek is part of the midface	UMLS:C4025324	hp.json	Anomaly of the cheeks|Abnormality of the cheek|Deformity of the cheeks|Malformation of the cheeks|Abnormality of the cheeks	http://purl.obolibrary.org/obo/HP_0004426		
HP:0004425	biolink:PhenotypicFeature	Flat forehead	A forehead with abnormal flatness.	UMLS:C1857485	hp.json	Frontal flattening|Flattened forehead|Flat forehead	http://purl.obolibrary.org/obo/HP_0004425		
UBERON:0004356	biolink:AnatomicalEntity	apical ectodermal ridge	Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP].	TAO:0002146|XAO:0004121|EMAPA:32744|AAO:0010760|Wikipedia:Apical_ectodermal_ridge|ZFA:0001702|UMLS:C1516037|NCIT:C34109	hp.json	crista ectodermalis apicalis|crista ectodermalis apicalis|AER|apical epidermal ridge	http://purl.obolibrary.org/obo/UBERON_0004356		pheno_slim
HP:0004420	biolink:PhenotypicFeature	Arterial thrombosis	The formation of a blood clot inside an artery.	SNOMEDCT_US:65198009|UMLS:C0151942	hp.json	Blood clot in artery	http://purl.obolibrary.org/obo/HP_0004420		
UBERON:0004357	biolink:AnatomicalEntity	paired limb/fin bud	An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP].	VHOG:0001258	hp.json	limb - fin bud|paired limb/fin bud|paired appendage bud	http://purl.obolibrary.org/obo/UBERON_0004357		homology_grouping
UBERON:0004354	biolink:AnatomicalEntity	male inguinal canal	An inguinal canal that is part of a male organism. Conveys the spermatic cord and its coverings + the ilioinguinal nerve.[WP,unvetted].	MA:0003256|EMAPA:26913	hp.json	inguinal canal of male	http://purl.obolibrary.org/obo/UBERON_0004354		pheno_slim
HP:0004478	biolink:PhenotypicFeature	Ethmoidal encephalocele		UMLS:C1843495	hp.json		http://purl.obolibrary.org/obo/HP_0004478		
HP:0004476	biolink:PhenotypicFeature	Aplasia cutis congenita over parietal area	A developmental defect resulting in the congenital absence of skin on the scalp in the parietal area.	UMLS:C1863492	hp.json	Absent cutis congenita over parietal area	http://purl.obolibrary.org/obo/HP_0004476		
HP:0004471	biolink:PhenotypicFeature	Aplasia cutis congenita over the scalp vertex	A developmental defect resulting in the congenital absence of skin on the scalp vertex, often just lateral to the midline.	UMLS:C1970112	hp.json	Aplasia cutis congenita of vertex|Absent cutis congenita of vertex	http://purl.obolibrary.org/obo/HP_0004471		
HP:0004470	biolink:PhenotypicFeature	Atretic occipital cephalocele	A congenital defect in the occipital region of the skull, covered by skin of the scalp and containing meninges or remnants of glial or neural tissues.	UMLS:C1836600	hp.json		http://purl.obolibrary.org/obo/HP_0004470		
CHEBI:60948	biolink:ChemicalSubstance	alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc	A linear trisaccharide comprising D-glucose (at the reducing end) having an alpha-D-galactosyl-(1->4)-beta-D-galactosyl moiety at the 4-position.	PMID:16133831|KEGG:G03416|PMID:17991151|PMID:2292729|GlyTouCan:G06000DZ|Reaxys:5386141|PMID:12020649|CAS:80446-87-3|PMID:2456994|PMID:9538266|GlyGen:G06000DZ	hp.json	(Gal)2 (Glc)1|WURCS=2.0/3,3,2/[a2122h-1x_1-5][a2112h-1b_1-5][a2112h-1a_1-5]/1-2-3/a4-b1_b4-c1|Galalpha1,4Gal-beta1,4Glc|Galalpha1-4Gal-beta1-4Glc|Pk|Galalpha1-4Gal-beta1-4Glc~OH|4-O-(4-O-alpha-D-galactopyranosyl-beta-D-galactopyranosyl)-D-glucopyranose|4'-galactosyllactose|alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-D-Glcp|Gal-alpha1,4Gal-beta1,4-Glc|alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-D-glucose|Gal-alpha-1,4-Gal-beta-1,4-Glc|alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-D-glucopyranose	http://purl.obolibrary.org/obo/CHEBI_60948		3_STAR
HP:0004474	biolink:PhenotypicFeature	Persistent open anterior fontanelle	The anterior fontanelle generally ossifies by around the 18th month of life. A persistent open anterior fontanelle is diagnosed if closure is delayed beyond this age.	UMLS:C1849537	hp.json	Front fontanelle stays open|Anterior fontanelle open in adults|Persistent, open anterior fontanel	http://purl.obolibrary.org/obo/HP_0004474		
HP:0004472	biolink:PhenotypicFeature	Mandibular hyperostosis	Hyperostosis (bony overgrowth) of the mandible.	UMLS:C4280523|UMLS:C4280522|UMLS:C4280521|UMLS:C4025321	hp.json	Hyperostosis of mandibular bone|Increased ossification of mandible|Thick mandibular bone|Overgrowth of mandibular bone|Thick lower jaw bone|Hyperostosis of lower jaw|Increased ossification of lower jaw|Increased ossification of mandibular bone|Excessive growth of mandibular bone	http://purl.obolibrary.org/obo/HP_0004472		
NBO:0000308	biolink:NamedThing	sensation behavior	"Cognitive perception of a sensation by any of the five senses -- vision, touch, smell, taste, and hearing." [NBO:GVG]		hp.json	behavior involving perception|perception behavior	http://purl.obolibrary.org/obo/NBO_0000308		
UBERON:0016398	biolink:AnatomicalEntity	lymph node of lower limb	A lymph node that is part of a hindlimb.	FMA:44310	hp.json		http://purl.obolibrary.org/obo/UBERON_0016398		
NBO:0000304	biolink:NamedThing	memory loss behavior	"Behavior related with the gradual loss of information and experiences stored in the memory of an organism." [NBO:GVG]		hp.json	forgetting	http://purl.obolibrary.org/obo/NBO_0000304		
CHEBI:35902	biolink:ChemicalSubstance	oxo monocarboxylic acid anion			hp.json	oxo monocarboxylic acid anions	http://purl.obolibrary.org/obo/CHEBI_35902		3_STAR
CHEBI:35903	biolink:ChemicalSubstance	oxo carboxylic acid anion	Any carboxylic acid anion containing at least one oxo group.		hp.json	oxo carboxylic acid anions	http://purl.obolibrary.org/obo/CHEBI_35903		3_STAR
UBERON:0016399	biolink:AnatomicalEntity	lymph node of upper limb	A lymph node that is part of a forelimb.	FMA:44311	hp.json		http://purl.obolibrary.org/obo/UBERON_0016399		
CHEBI:35907	biolink:ChemicalSubstance	glutarate(1-)	A dicarboxylic acid monoanion that is the conjugate base of glutaric acid.	Beilstein:3904478|Reaxys:3904478|Gmelin:326031	hp.json	hydrogen glutarate|4-carboxybutanoate	http://purl.obolibrary.org/obo/CHEBI_35907		3_STAR
CHEBI:5931	biolink:ChemicalSubstance	insulin (human)	An insulin that is produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two peptide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes.	PMID:32208558|PMID:32398693|KEGG:C00723|PMID:22715632|PMID:31876563|PMID:31821343|PMID:31301295|DrugBank:DB00030|PMID:32797824|PMID:32629793|PMID:22843207|PMID:8019699|PMID:22617471|PMID:22249812|CAS:11061-68-0|KEGG:D00085	hp.json	Insulin recombinant|insuline humaine|Insulin|insulin human|insulinum humanum|insulin (recombinant)|Exubera|human insulin|insulina humana	http://purl.obolibrary.org/obo/CHEBI_5931		3_STAR
HP:0004488	biolink:PhenotypicFeature	Macrocephaly at birth	The presence of an abnormally large skull with onset at birth.	UMLS:C1836599	hp.json	Big skull present since birth|Large skull present at birth|Congenital large skull|Large head present since birth|Congenital macrocephaly|Large skull present since birth|Big cranium present since birth|Big head present at birth|Head circumference large for gestational age|Big skull present at birth|Large cranium present at birth|Big head present since birth|Large head present at birth|Congenital large cranium|Large cranium present since birth|Congenital large head|Big cranium present at birth	http://purl.obolibrary.org/obo/HP_0004488		hposlim_core
HP:0004487	biolink:PhenotypicFeature	Acrobrachycephaly	An abnormality of head shape characterized by the presence of a short, wide head as well as a pointy or conical form of the top of the head owing to premature closure of the coronal and lambdoid sutures.	UMLS:C1863395|SNOMEDCT_US:711039004	hp.json		http://purl.obolibrary.org/obo/HP_0004487		
HP:0004482	biolink:PhenotypicFeature	Relative macrocephaly	A relatively mild degree of macrocephaly in which the head circumference is not above two standard deviations from the mean, but appears dysproportionately large when other factors such as body stature are taken into account.	SNOMEDCT_US:3961000119101|UMLS:C1849075	hp.json	Macrocephaly, relative|Relatively large head|Disproportionately large head	http://purl.obolibrary.org/obo/HP_0004482		
CHEBI:23924	biolink:ChemicalSubstance	enzyme inhibitor	A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.		hp.json	inhibidores enzimaticos|enzyme inhibitor|inhibiteur enzymatique|inhibiteurs enzymatiques|enzyme inhibitors|inhibidor enzimatico	http://purl.obolibrary.org/obo/CHEBI_23924		3_STAR
HP:0004481	biolink:PhenotypicFeature	Progressive macrocephaly	The progressive development of an abnormally large skull.	UMLS:C1859896	hp.json	Progressively abnormally enlarging skull|Macrocephaly, progressive|Progressively abnormally enlarging cranium	http://purl.obolibrary.org/obo/HP_0004481		
HP:0004485	biolink:PhenotypicFeature	Cessation of head growth	Stagnation of head growth seen as flattening of the head circumference curve.	UMLS:C4025319	hp.json	Skull stopped growing|Head stopped growing|Cranium stopped growing	http://purl.obolibrary.org/obo/HP_0004485		
HP:0004484	biolink:PhenotypicFeature	Craniofacial asymmetry	Asymmetry of the bones of the skull and the face.	UMLS:C4025320	hp.json	Malformation of craniofacial shape|Abnormality of craniofacial shape|Uneven craniofacial structures	http://purl.obolibrary.org/obo/HP_0004484		
HP:0004454	biolink:PhenotypicFeature	Abnormal middle ear reflexes		UMLS:C1970887	hp.json		http://purl.obolibrary.org/obo/HP_0004454		
HP:0004459	biolink:PhenotypicFeature	Exostosis of the external auditory canal	A benign bony growth projecting outward from a bone surface within the external auditory canal.	UMLS:C0155411|SNOMEDCT_US:19560007	hp.json	External auditory canal exostoses	http://purl.obolibrary.org/obo/HP_0004459		
HP:0004458	biolink:PhenotypicFeature	Dilatated internal auditory canal	The presence of a dilated inner part of external acoustic meatus.	UMLS:C2676973	hp.json	Bulbous internal auditory canal|Enlarged internal auditory canal	http://purl.obolibrary.org/obo/HP_0004458		
HP:0004453	biolink:PhenotypicFeature	Overfolding of the superior helices	A condition in which the superior portion of the helix is folded over to a greater degree than normal.	UMLS:C1865304	hp.json	Overfolding of superior helix	http://purl.obolibrary.org/obo/HP_0004453		
HP:0004452	biolink:PhenotypicFeature	Abnormality of the middle ear ossicles	An abnormality of the middle-ear ossicles (three small bones called malleus, incus, and stapes) that are contained within the middle ear and serve to transmit sounds from the air to the fluid-filled labyrinth (cochlea).	UMLS:C1836678	hp.json	Ossicular malformation|Malformed ossicles	http://purl.obolibrary.org/obo/HP_0004452		hposlim_core
HP:0004451	biolink:PhenotypicFeature	Postauricular skin tag	A rudimentary tag of ear tissue often containing a core of cartilage and located just in back of the auricle (outer part of the ear).	UMLS:C4025323	hp.json	Postauricular acrochordon|Postauricular fibroepithelial polyp|Skin tag behind the ear	http://purl.obolibrary.org/obo/HP_0004451		
HP:0004450	biolink:PhenotypicFeature	Preauricular skin furrow	A groove of the skin immediately in front of the ear.	UMLS:C1852411	hp.json	Preauricular skin furrows|Skin groove in front of the ear|Skin sulcus in front of the ear|Preauricular skin groove|Preauricular skin sulcus	http://purl.obolibrary.org/obo/HP_0004450		
HP:0004468	biolink:PhenotypicFeature	Anomalous tracheal cartilage	An abnormality of the C-shaped rings of hyaline cartilage, normally 16 to 20 in number, that occupy the anterior two-thirds of the circumference of the trachea (the posterior portion of the ring is completed by fibrous and smooth muscle tissue).	UMLS:C1863406	hp.json	Abnormal tracheal cartilaginous ring	http://purl.obolibrary.org/obo/HP_0004468		
UBERON:0004396	biolink:AnatomicalEntity	epiphysis of second metatarsal bone	An epiphysis that is part of a metatarsal bone of digit 2 [Automatically generated definition].	FMA:33816	hp.json	metatarsal 2 epiphysis|second metatarsal bone epiphysis	http://purl.obolibrary.org/obo/UBERON_0004396		
HP:0004467	biolink:PhenotypicFeature	Preauricular pit	Small indentation anterior to the insertion of the ear.	UMLS:C0546969|MSH:C563015|UMLS:C0266610|SNOMEDCT_US:204272007|SNOMEDCT_US:1955003|SNOMEDCT_US:204271000|UMLS:C0266625	hp.json	Preauricular pits|Preauricular earpits|Ear pit|Preauricular sinus|Pit in front of the ear|Preauricular fistulas	http://purl.obolibrary.org/obo/HP_0004467		
UBERON:0004397	biolink:AnatomicalEntity	epiphysis of third metatarsal bone	An epiphysis that is part of a metatarsal bone of digit 3 [Automatically generated definition].	FMA:86313	hp.json	third metatarsal bone epiphysis|metatarsal 3 epiphysis	http://purl.obolibrary.org/obo/UBERON_0004397		
HP:0004466	biolink:PhenotypicFeature	Prolonged brainstem auditory evoked potentials		UMLS:C4025322	hp.json		http://purl.obolibrary.org/obo/HP_0004466		
UBERON:0004394	biolink:AnatomicalEntity	epiphysis of fourth metacarpal bone	An epiphysis that is part of a metacarpal bone of digit 4 [Automatically generated definition].	FMA:86329	hp.json	fourth metacarpal bone epiphysis|metacarpal 4 epiphysis	http://purl.obolibrary.org/obo/UBERON_0004394		
UBERON:0004395	biolink:AnatomicalEntity	epiphysis of first metatarsal bone	An epiphysis that is part of a metatarsal bone of digit 1 [Automatically generated definition].	FMA:33815	hp.json	metatarsal 1 epiphysis|first metatarsal bone epiphysis	http://purl.obolibrary.org/obo/UBERON_0004395		pheno_slim
UBERON:0004392	biolink:AnatomicalEntity	epiphysis of second metacarpal bone	An epiphysis that is part of a metacarpal bone of digit 2 [Automatically generated definition].	FMA:33794	hp.json	metacarpal 2 epiphysis|second metacarpal bone epiphysis	http://purl.obolibrary.org/obo/UBERON_0004392		
UBERON:0004393	biolink:AnatomicalEntity	epiphysis of third metacarpal bone	An epiphysis that is part of a metacarpal bone of digit 3 [Automatically generated definition].	FMA:86328	hp.json	third metacarpal bone epiphysis|metacarpal 3 epiphysis	http://purl.obolibrary.org/obo/UBERON_0004393		
UBERON:0004390	biolink:AnatomicalEntity	epiphysis of metacarpal bone	An epiphysis that is part of a metacarpal bone [Automatically generated definition].	FMA:33792	hp.json	epiphysis of metacarpal|metacarpal epiphysis|metacarpal bone epiphysis	http://purl.obolibrary.org/obo/UBERON_0004390		pheno_slim
UBERON:0004391	biolink:AnatomicalEntity	epiphysis of first metacarpal bone	An epiphysis that is part of a metacarpal bone of digit 1 [Automatically generated definition].	FMA:33793	hp.json	first metacarpal bone epiphysis|metacarpal 1 epiphysis	http://purl.obolibrary.org/obo/UBERON_0004391		pheno_slim
HP:0004469	biolink:PhenotypicFeature	Chronic bronchitis	Chronic inflammation of the bronchi.	SNOMEDCT_US:63480004|UMLS:C0008677|MSH:D029481	hp.json		http://purl.obolibrary.org/obo/HP_0004469		
HP:0004464	biolink:PhenotypicFeature	Postauricular pit	Benign congenital lesion of the postauricular soft tissue consisting of a blind-ending narrow tube or pit.	UMLS:C0395905|SNOMEDCT_US:43887004	hp.json	Posterior auricular pit|Postauricular earpits|Postauricular fistula|Posterior auricular sinus|Pit behind the ear	http://purl.obolibrary.org/obo/HP_0004464		hposlim_core
CHEBI:23906	biolink:ChemicalSubstance	monoatomic cation			hp.json	monoatomic cations	http://purl.obolibrary.org/obo/CHEBI_23906		3_STAR
HP:0004463	biolink:PhenotypicFeature	Absent brainstem auditory responses	Lack of measurable response to stimulation of auditory evoked potentials.	UMLS:C1836742	hp.json	No auditory brainstem response	http://purl.obolibrary.org/obo/HP_0004463		
UBERON:0004398	biolink:AnatomicalEntity	epiphysis of fourth metatarsal bone	An epiphysis that is part of a metatarsal bone of digit 4 [Automatically generated definition].	FMA:86314	hp.json	fourth metatarsal bone epiphysis|metatarsal 4 epiphysis	http://purl.obolibrary.org/obo/UBERON_0004398		
CHEBI:23905	biolink:ChemicalSubstance	monoatomic anion			hp.json	monoatomic anions	http://purl.obolibrary.org/obo/CHEBI_23905		3_STAR
UBERON:0004399	biolink:AnatomicalEntity	epiphysis of fifth metatarsal bone	An epiphysis that is part of a metatarsal bone of digit 5 [Automatically generated definition].	FMA:86315	hp.json	fifth metatarsal bone epiphysis|metatarsal 5 epiphysis	http://purl.obolibrary.org/obo/UBERON_0004399		
HP:0004461	biolink:PhenotypicFeature	Congenital earlobe sinuses	Pits in the earlobes at the location where ears are typically pierced for earrings.	UMLS:C1969394	hp.json		http://purl.obolibrary.org/obo/HP_0004461		
PATO:0002269	biolink:NamedThing	accumulation	A structural quality of the collection or massing of one physical object within another physical object.		hp.json	pooled	http://purl.obolibrary.org/obo/PATO_0002269		scalar_slim|relational_slim|attribute_slim
UBERON:0006960	biolink:AnatomicalEntity	ovary stroma	The stroma of the ovary is a peculiar soft tissue, abundantly supplied with blood vessels, consisting for the most part of spindle-shaped cells with a small amount of ordinary connective tissue. These cells have been regarded by some anatomists as unstriped muscle cells, which, indeed, they most resemble; by others as connective-tissue cells. On the surface of the organ this tissue is much condensed, and forms a layer composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial cells resembling those of the testis.	CALOHA:TS-1246|UMLS:C0737271|EMAPA:28880|MA:0002991|SCTID:259306002|FMA:18626|Wikipedia:Stroma_of_ovary|NCIT:C33638	hp.json	stroma ovarii|stroma ovarica|interstitial tissue of ovary|ovary stroma|stroma ovarii|stroma of the ovary|stroma of the ovary|ovarian stroma	http://purl.obolibrary.org/obo/UBERON_0006960		
CHEBI:33356	biolink:ChemicalSubstance	iron group element atom			hp.json	iron group elements|iron group element|group 8 elements	http://purl.obolibrary.org/obo/CHEBI_33356		3_STAR
PATO:0002265	biolink:NamedThing	behavioural activity	A behavioral quality of a process inhering in a bearer by virtue of the bearer's disposition to exhibit marked activity.		hp.json		http://purl.obolibrary.org/obo/PATO_0002265		scalar_slim|disposition_slim|attribute_slim
CHEBI:33358	biolink:ChemicalSubstance	cobalt group element atom			hp.json	group 9 elements|cobalt group element|cobalt group elements	http://purl.obolibrary.org/obo/CHEBI_33358		3_STAR
PATO:0002266	biolink:NamedThing	3-D shape	A shape that inheres in a 3 dimensional entity.		hp.json		http://purl.obolibrary.org/obo/PATO_0002266		
UBERON:0006966	biolink:AnatomicalEntity	coronary capillary	A capillary that is part of the coronary system.	ZFA:0005813	hp.json	heart capillary	http://purl.obolibrary.org/obo/UBERON_0006966		
UBERON:0006965	biolink:AnatomicalEntity	vascular cord	The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA].	TAO:0005077|EFO:0003709|ZFA:0005077	hp.json		http://purl.obolibrary.org/obo/UBERON_0006965		efo_slim
GO:0019730	biolink:BiologicalProcess	antimicrobial humoral response	An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.		hp.json		http://purl.obolibrary.org/obo/GO_0019730		
UBERON:0004301	biolink:AnatomicalEntity	middle phalanx	A phalanx located between proximal and distal phalanges.	EMAPA:35572|AAO:0010677|MA:0002915	hp.json	penultimate phalanx|phalanx II|intermediate phalanx|medial phalanx|phalanx 2	http://purl.obolibrary.org/obo/UBERON_0004301		
UBERON:0004302	biolink:AnatomicalEntity	proximal phalanx	Proximal-most phalanx within a digit.	EMAPA:35716|MA:0002916|AAO:0010680	hp.json	phalanx I|proximal-most phalanx|phalanx 1	http://purl.obolibrary.org/obo/UBERON_0004302		
UBERON:0004300	biolink:AnatomicalEntity	distal phalanx	Distal-most phalanx within a digit.	EMAPA:35287|AAO:0010676|MA:0002914	hp.json	phalanx distalis|terminal phalanx|phalanx distalis|ungual phalanx	http://purl.obolibrary.org/obo/UBERON_0004300		pheno_slim
UBERON:0006948	biolink:AnatomicalEntity	efferent duct epithelium	An epithelium that is part of a efferent duct.	FMA:19195|EMAPA:29747|MA:0001734	hp.json	epithelium of efferent ductule of testis	http://purl.obolibrary.org/obo/UBERON_0006948		
UBERON:0006947	biolink:AnatomicalEntity	male genital duct	A duct or series of ducts that transports sperm from the gonad. In mammals this is from the seminiferous tubules through rete testis, vas efferentia, epididymis, vas deferens, ejeculatory duct to the urethra.	FMA:55678|ZFA:0001268|TAO:0001268	hp.json	sperm duct|sperm ducts	http://purl.obolibrary.org/obo/UBERON_0006947		grouping_class
GO:0005102	biolink:MolecularActivity	signaling receptor binding	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.	Wikipedia:Ligand_(biochemistry)	hp.json	receptor ligand|receptor binding|receptor-associated protein activity	http://purl.obolibrary.org/obo/GO_0005102		goslim_plant|goslim_flybase_ribbon|goslim_chembl|goslim_mouse|goslim_agr
GO:0042098	biolink:BiologicalProcess	T cell proliferation	The expansion of a T cell population by cell division. Follows T cell activation.		hp.json	T-cell proliferation|T lymphocyte proliferation|T-lymphocyte proliferation	http://purl.obolibrary.org/obo/GO_0042098		
GO:0019748	biolink:BiologicalProcess	secondary metabolic process	The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.	Wikipedia:Secondary_metabolism	hp.json	secondary metabolite metabolism|secondary metabolism|secondary metabolite metabolic process	http://purl.obolibrary.org/obo/GO_0019748		goslim_pombe|goslim_pir|goslim_plant|goslim_chembl
CHEBI:33366	biolink:ChemicalSubstance	copper group element atom			hp.json	coinage metals|group 11 elements|copper group element|copper group elements	http://purl.obolibrary.org/obo/CHEBI_33366		3_STAR
GO:0019747	biolink:BiologicalProcess	regulation of isoprenoid metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.		hp.json	regulation of isoprenoid metabolism	http://purl.obolibrary.org/obo/GO_0019747		
UBERON:0006957	biolink:AnatomicalEntity	submandibular gland primordium epithelium	An epithelium that is part of a submandibular gland primordium.	EHDAA:9257|EMAPA:17756|EHDAA2:0001940	hp.json	submaxillary gland primordium epithelium	http://purl.obolibrary.org/obo/UBERON_0006957		
UBERON:0006956	biolink:AnatomicalEntity	buccal mucosa	The inner lining of the cheeks and lips.	CALOHA:TS-2349|NCIT:C12505|FMA:59785|UMLS:C1578559|BTO:0003833	hp.json		http://purl.obolibrary.org/obo/UBERON_0006956		pheno_slim
UBERON:0006955	biolink:AnatomicalEntity	uterine epithelium	An epithelium that is part of a uterus.	BTO:0003082	hp.json	uterus epithelium	http://purl.obolibrary.org/obo/UBERON_0006955		
PATO:0002270	biolink:NamedThing	increased accumulation	An increased number of physical objects that are accumulated within another physical object usually as a result of a failure to break down or remove objects in a timely manner.		hp.json	accumulated	http://purl.obolibrary.org/obo/PATO_0002270		relational_slim|value_slim
UBERON:0006953	biolink:AnatomicalEntity	ejaculatory duct epithelium	The ejaculatory duct epithelium is composed of cuboidal to columnar cells between or through which project the terminal parts of the ducts of the unicellular prostate glands.	EMAPA:29786|BTO:0002618	hp.json		http://purl.obolibrary.org/obo/UBERON_0006953		
UBERON:0006938	biolink:AnatomicalEntity	pinna surface epithelium	An epithelium that is part of a pinna.	EMAPA:17592|VHOG:0000632|EHDAA:8983|EHDAA2:0001470	hp.json		http://purl.obolibrary.org/obo/UBERON_0006938		
UBERON:0006937	biolink:AnatomicalEntity	inner ear epithelium	The epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals.	EMAPA:32883|MA:0001189	hp.json		http://purl.obolibrary.org/obo/UBERON_0006937		pheno_slim
UBERON:0006936	biolink:AnatomicalEntity	thymus subcapsular epithelium	The epithelial cells lining the capsule and trabeculae of the thymus.	MA:0000769	hp.json		http://purl.obolibrary.org/obo/UBERON_0006936		pheno_slim|human_reference_atlas
PATO:0002283	biolink:NamedThing	decreased mobility	A mobility which is relative low.		hp.json		http://purl.obolibrary.org/obo/PATO_0002283		value_slim
PATO:0002287	biolink:NamedThing	increased elasticity	An elasticity which is relatively high.		hp.json		http://purl.obolibrary.org/obo/PATO_0002287		value_slim
PATO:0002288	biolink:NamedThing	decreased elasticity	An elasticity which is relatively low.		hp.json		http://purl.obolibrary.org/obo/PATO_0002288		value_slim
UBERON:0006946	biolink:AnatomicalEntity	efferent duct	The efferent ducts (or efferent ductules or ductuli efferentes) connect the rete testis with the initial section of the epididymis. The ductuli are unilaminar and composed of columnar ciliated and non-ciliated (absorptive) cells. The ciliated cells serve to stir the luminal fluids, possibly to help ensure homogeneous absorption of water from the fluid produced by the testis, which results in an increase in the concentration of luminal sperm. The epithelium is surrounded by a band of smooth muscle that helps to propel the sperm toward the epididymis.	NCIT:C32492|FMA:19081|EMAPA:18993|MA:0000398|AAO:0010532|UMLS:C0228013	hp.json	seminal duct|efferent ductule|ductuli efferentes testis|efferent ductule|vasa efferentia|ductuli efferentes testis	http://purl.obolibrary.org/obo/UBERON_0006946		pheno_slim
CHEBI:57305	biolink:ChemicalSubstance	glycine zwitterion	An amino acid zwitterion arising from transfer of a proton from the carboxy to the amino group of glycine.	Gmelin:1807|MetaCyc:GLY	hp.json	glycine|2-azaniumylacetate	http://purl.obolibrary.org/obo/CHEBI_57305		3_STAR
PATO:0002281	biolink:NamedThing	biscupidate	A cuscpidate quality inhering in a bearer by virtue of the bearer possessing two cusps.		hp.json	bicuspid	http://purl.obolibrary.org/obo/PATO_0002281		
PATO:0002282	biolink:NamedThing	increased mobility	A mobility which is relative high.		hp.json		http://purl.obolibrary.org/obo/PATO_0002282		value_slim
UBERON:0006929	biolink:AnatomicalEntity	glandular columnar epithelium	Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA].	FMA:64800|NCIT:C13182|UMLS:C0225337	hp.json		http://purl.obolibrary.org/obo/UBERON_0006929		
UBERON:0006925	biolink:AnatomicalEntity	digestive system gland	Any gland that is part of the digestive system.	BTO:0000345|AAO:0000130	hp.json	digestive gland	http://purl.obolibrary.org/obo/UBERON_0006925		organ_slim
PATO:0002297	biolink:NamedThing	decreased cellular motility	A cellular motility which is lower relative to the normal or average.		hp.json		http://purl.obolibrary.org/obo/PATO_0002297		value_slim
GO:0019725	biolink:BiologicalProcess	cellular homeostasis	Any process involved in the maintenance of an internal steady state at the level of the cell.		hp.json		http://purl.obolibrary.org/obo/GO_0019725		goslim_candida|goslim_plant|goslim_aspergillus
PATO:0002298	biolink:NamedThing	increased cellular motility	A cellular motility which is higher relative to the normal or average.		hp.json		http://purl.obolibrary.org/obo/PATO_0002298		value_slim
PATO:0002299	biolink:NamedThing	tubular	A cylindrical shape that is hollow.		hp.json	tube like|tube-shaped|tubulate	http://purl.obolibrary.org/obo/PATO_0002299		
UBERON:0006934	biolink:AnatomicalEntity	sensory epithelium	Simple columnar epithelium made up of cells specialized to serve as sensory cells for the reception of external stimuli, as the sensory cells of the cochlea, vestibule, nasal mucosa, and tongue.	FMA:62410|SCTID:309045006|CALOHA:TS-0682	hp.json	neuroepithelium	http://purl.obolibrary.org/obo/UBERON_0006934		
UBERON:0006932	biolink:AnatomicalEntity	vestibular epithelium	An epithelium that is part of a vestibular labyrinth.	EMAPA:35921|RETIRED_EHDAA2:0000834|EMAPA:32884|FMA:75606|BTO:0005581|MA:0002892	hp.json	epithelium of vestibular labyrinth|inner ear vestibular component epithelium|vestibular sensory epithelium	http://purl.obolibrary.org/obo/UBERON_0006932		
UBERON:0006931	biolink:AnatomicalEntity	stomach glandular region mucosa	Stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region.	MA:0001614|EMAPA:27167	hp.json	stomach glandular region glandular mucous membrane	http://purl.obolibrary.org/obo/UBERON_0006931		
UBERON:0006930	biolink:AnatomicalEntity	glandular cuboidal epithelium		FMA:66809	hp.json		http://purl.obolibrary.org/obo/UBERON_0006930		
PATO:0002290	biolink:NamedThing	aplastic/hypoplastic			hp.json		http://purl.obolibrary.org/obo/PATO_0002290		
CHEBI:33340	biolink:ChemicalSubstance	zinc group element atom			hp.json	zinc group element|group 12 elements|zinc group elements	http://purl.obolibrary.org/obo/CHEBI_33340		3_STAR
PATO:0002291	biolink:NamedThing	agenesis	Absence of a tissue or organ due to failure to develop.		hp.json		http://purl.obolibrary.org/obo/PATO_0002291		
CHEBI:33318	biolink:ChemicalSubstance	main group element atom	An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table.		hp.json	Hauptgruppenelement|main group element|main group elements|Hauptgruppenelemente	http://purl.obolibrary.org/obo/CHEBI_33318		3_STAR
PATO:0002226	biolink:NamedThing	subcylindrical	A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical.		hp.json		http://purl.obolibrary.org/obo/PATO_0002226		value_slim
UBERON:0004341	biolink:AnatomicalEntity	primitive streak	The primitive streak is a structure that forms during the early stages of avian, reptilian and mammalian embryonic development[WP]. the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm[MP].	NCIT:C28402|EMAPA:16072|MESH:D054240|EHDAA:185|FMA:293110|VHOG:0001202|EHDAA2:0001525|UMLS:C0033153	hp.json	primitive streak - blastopore - germ ring	http://purl.obolibrary.org/obo/UBERON_0004341		pheno_slim|early_development
UBERON:0004340	biolink:AnatomicalEntity	allantois	A membranous sac that develops from the posterior part of the alimentary canal in the embryos of mammals, birds, and reptiles, and it is important in the formation of the umbilical cord and placenta in mammals[VHOG].	NCIT:C34101|MESH:D000482|UMLS:C0002084|BTO:0000474|EMAPA:16107|EMAPA_RETIRED:16084|RETIRED_EHDAA2:0000114|Wikipedia:Allantois|EHDAA2:0001504|VHOG:0000738|SCTID:308825007	hp.json	allantoic bud	http://purl.obolibrary.org/obo/UBERON_0004340		pheno_slim
CHEBI:35972	biolink:ChemicalSubstance	dihydroxy monocarboxylic acid	Any  hydroxy monocarboxylic acid carrying at least two hydroxy groups.		hp.json	dihydroxy monocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_35972		3_STAR
UBERON:0004347	biolink:AnatomicalEntity	limb bud	An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP].	GAID:1307|NCIT:C34203|MESH:D018878|AAO:0010375|EMAPA:35944|XAO:0003161|BTO:0001640|FMA:296780|UMLS:C0282505	hp.json	limbbud|gemmae membrorum|limb buds	http://purl.obolibrary.org/obo/UBERON_0004347		pheno_slim
UBERON:0004348	biolink:AnatomicalEntity	optic eminence	The embryonic structure that gives rise to the corneal ectoderm.	EMAPA:16322|VHOG:0001296|RETIRED_EHDAA2:0001308|EHDAA:938	hp.json		http://purl.obolibrary.org/obo/UBERON_0004348		pheno_slim
UBERON:0004345	biolink:AnatomicalEntity	trophectoderm	Outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition.	EHDAA2:0002091|EMAPA:16046|VHOG:0000979|EHDAA:56|BTO:0001840	hp.json		http://purl.obolibrary.org/obo/UBERON_0004345		pheno_slim|early_development
UBERON:0004346	biolink:AnatomicalEntity	gubernaculum (male or female)	Embryonic structures which begin as undifferentiated mesenchyme attaching to the caudal end of the gonads. The gubernaculum is present only during the development of the urinary and reproductive organs, being replaced by distinct vestiges in males and females[WP]. Enitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus[MP].	UMLS:C0228051|NCIT:C82952	hp.json	gubernaculae|caudal suspensory ligament|Gabernaculum|gubernaculum	http://purl.obolibrary.org/obo/UBERON_0004346		pheno_slim
UBERON:0004344	biolink:AnatomicalEntity	cardinal vein	Any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column.	EMAPA:16354|NCIT:C34116|EHDAA2:0000213|EHDAA:1310|XAO:0000052|UMLS:C0231085|AAO:0011022|BTO:0004385|VHOG:0001197	hp.json	Cuvierian vein|cardinal vein system|cardinal sinus	http://purl.obolibrary.org/obo/UBERON_0004344		pheno_slim
UBERON:0004329	biolink:AnatomicalEntity	proximal phalanx of manual digit 3	A proximal phalanx that is part of a hand digit 3 [Automatically generated definition].	FMA:23920	hp.json	proximal phalanx of manual digit III|hand digit 3 proximal phalanx|third finger proximal phalanx|proximal phalanx of 3rd finger|proximal phalanx of 3rd digit of hand|manual digit 3 proximal phalanx|third proximal phalanx of hand|3rd finger proximal phalanx|manual phalanx III-1|proximal phalanx of third finger|proximal phalanx of third digit of hand|3rd digit of hand proximal phalanx|proximal phalanx of middle finger	http://purl.obolibrary.org/obo/UBERON_0004329		pheno_slim
HP:0004409	biolink:PhenotypicFeature	Hyposmia	A decreased sensitivity to odorants (that is, a decreased ability to perceive odors).	SNOMEDCT_US:83156004|UMLS:C2364082	hp.json	Sense of smell impaired|Decreased smell sensation	http://purl.obolibrary.org/obo/HP_0004409		hposlim_core
HP:0004408	biolink:PhenotypicFeature	Abnormality of the sense of smell	An anomaly in the ability to perceive and distinguish scents (odors).	UMLS:C4021655	hp.json	Abnormality of the sense of smell|Abnormality of olfaction|Abnormal sense of smell|Smell defect	http://purl.obolibrary.org/obo/HP_0004408		hposlim_core
HP:0004407	biolink:PhenotypicFeature	Bony paranasal bossing		UMLS:C1857499	hp.json		http://purl.obolibrary.org/obo/HP_0004407		
UBERON:0004330	biolink:AnatomicalEntity	proximal phalanx of manual digit 4	A proximal phalanx that is part of a hand digit 4 [Automatically generated definition].	FMA:23921	hp.json	manual digit 4 proximal phalanx|proximal phalanx of 4th finger|proximal phalanx of manual digit IV|fourth proximal phalanx of hand|proximal phalanx of ring finger|4th digit of hand proximal phalanx|manual phalanx IV-1|proximal phalanx of fourth finger|proximal phalanx of fourth digit of hand|fourth finger proximal phalanx|hand digit 4 proximal phalanx|proximal phalanx of 4th digit of hand|4th finger proximal phalanx	http://purl.obolibrary.org/obo/UBERON_0004330		pheno_slim
HP:0004401	biolink:PhenotypicFeature	Meconium ileus	Obstruction of the intestine due to abnormally thick meconium.	SNOMEDCT_US:233662009|SNOMEDCT_US:86092005|UMLS:C0398349|SNOMEDCT_US:206523001|UMLS:C2939175|UMLS:C3553397	hp.json	Meconium ileus on ultrasonography|Distal intestinal obstruction syndrome|Meconium ileus in neonates	http://purl.obolibrary.org/obo/HP_0004401		
UBERON:0004331	biolink:AnatomicalEntity	proximal phalanx of manual digit 5	A proximal phalanx that is part of a hand digit 5 [Automatically generated definition].	FMA:23922	hp.json	proximal phalanx of fifth finger|manual digit 5 proximal phalanx|fifth proximal phalanx of hand|proximal phalanx of 5th finger|proximal phalanx of fifth digit of hand|manual phalanx V-1|5th digit of hand proximal phalanx|proximal phalanx of 5th digit of hand|5th finger proximal phalanx|proximal phalanx of manual digit V|proximal phalanx of little finger|hand digit 5 proximal phalanx|fifth finger proximal phalanx	http://purl.obolibrary.org/obo/UBERON_0004331		pheno_slim
HP:0004400	biolink:PhenotypicFeature	Abnormality of the pylorus	An abnormality of the pylorus.	UMLS:C4025326	hp.json		http://purl.obolibrary.org/obo/HP_0004400		
HP:0004406	biolink:PhenotypicFeature	Spontaneous, recurrent epistaxis		UMLS:C3809715	hp.json	Recurrent epistaxis|Spontaneous, recurrent nosebleed|Recurring nosebleed|Recurrent epistaxes	http://purl.obolibrary.org/obo/HP_0004406		
HP:0004405	biolink:PhenotypicFeature	Prominent nipples		UMLS:C1855513	hp.json	Prominent nipples	http://purl.obolibrary.org/obo/HP_0004405		hposlim_core
HP:0004404	biolink:PhenotypicFeature	Abnormal nipple morphology	An abnormality of the nipple.	SNOMEDCT_US:700153004|UMLS:C3839073	hp.json	Abnormality of the nipple	http://purl.obolibrary.org/obo/HP_0004404		hposlim_core
CHEBI:35987	biolink:ChemicalSubstance	diamino acid	Any amino acid carrying two amino groups.		hp.json		http://purl.obolibrary.org/obo/CHEBI_35987		3_STAR
HP:0004403	biolink:PhenotypicFeature	Proximal esophageal atresia		UMLS:C4025325	hp.json		http://purl.obolibrary.org/obo/HP_0004403		
UBERON:0004338	biolink:AnatomicalEntity	proximal phalanx of manual digit 1	A proximal phalanx that is part of a hand digit 1 [Automatically generated definition].	FMA:23918	hp.json	manual digit 1 proximal phalanx|manual phalanx I-1|first proximal phalanx of hand|proximal phalanx of first digit of hand|proximal phalanx of thumb|thumb proximal|proximal phalanx of manual digit I	http://purl.obolibrary.org/obo/UBERON_0004338		pheno_slim
UBERON:0004339	biolink:AnatomicalEntity	vault of skull	Upper part of skull, consisting of parietals, frontals, post-parietals, and in some species the squamosal and a portion of the alisphenoid.	VHOG:0000331|NCIT:C81188|EMAPA:18016|UMLS:C0205950|FMA:52800|EHDAA:9538|EHDAA2:0002167|ZFA:0005606	hp.json	calva|skullcap|skull vault|calvaria|skull roof|cranial vault|calvarium	http://purl.obolibrary.org/obo/UBERON_0004339		pheno_slim
UBERON:0004336	biolink:AnatomicalEntity	proximal phalanx of pedal digit 5	A proximal phalanx that is part of a pedal digit 5 [Automatically generated definition].	FMA:32621	hp.json	5th toe proximal phalanx|pedal phalanx V-1|proximal phalanx of pedal digit V|fifth proximal phalanx of foot|proximal phalanx of foot digit 5|proximal phalanx of fifth digit of foot|proximal phalanx of little toe|proximal phalanx of 5th toe|proximal phalanx of the 5th toe|predal digit 5 proximal phalanx|foot digit 5 proximal phalanx|proximal phalanx of fifth toe	http://purl.obolibrary.org/obo/UBERON_0004336		pheno_slim
UBERON:0004337	biolink:AnatomicalEntity	distal phalanx of manual digit 1	A distal phalanx that is part of a hand digit 1 [Automatically generated definition].	FMA:23945	hp.json	distal phalanx of first digit of hand|distal phalanx of manual digit I|PDP|first distal phalanx of hand|manual digit 1 distal phalanx|distal phalanx of thumb|thumb distal phalanx|pollical distal phalanx	http://purl.obolibrary.org/obo/UBERON_0004337		pheno_slim
UBERON:0004334	biolink:AnatomicalEntity	proximal phalanx of pedal digit 3	A proximal phalanx that is part of a pedal digit 3 [Automatically generated definition].	FMA:32619	hp.json	proximal phalanx of foot digit 3|proximal phalanx of third toe|predal digit 3 proximal phalanx|proximal phalanx of the 3rd toe|proximal phalanx of 3rd toe|foot digit 3 proximal phalanx|third proximal phalanx of foot|3rd toe proximal phalanx|proximal phalanx of third digit of foot|pedal phalanx III-1|proximal phalanx of pedal digit III	http://purl.obolibrary.org/obo/UBERON_0004334		pheno_slim
UBERON:0004335	biolink:AnatomicalEntity	proximal phalanx of pedal digit 4	A proximal phalanx that is part of a pedal digit 4 [Automatically generated definition].	FMA:32620	hp.json	4th toe proximal phalanx|proximal phalanx of pedal digit IV|proximal phalanx of fourth toe|fourth proximal phalanx of foot|proximal phalanx of foot digit 4|proximal phalanx of the 4th toe|proximal phalanx of 4th toe|predal digit 4 proximal phalanx|proximal phalanx of fourth digit of foot|foot digit 4 proximal phalanx|pedal phalanx IV-1	http://purl.obolibrary.org/obo/UBERON_0004335		pheno_slim
UBERON:0004332	biolink:AnatomicalEntity	proximal phalanx of pedal digit 1	A proximal phalanx that is part of a pedal digit 1 [Automatically generated definition].	FMA:43252	hp.json	proximal phalanx of great toe|predal digit 1 proximal phalanx|proximal phalanx of foot digit 1|proximal phalanx of hallux|foot digit 1 proximal phalanx|hallux proximal phalanx|proximal phalanx of the 1st toe|pedal phalanx I-1|proximal phalanx of pedal digit I|proximal phalanx of big toe	http://purl.obolibrary.org/obo/UBERON_0004332		pheno_slim
UBERON:0004333	biolink:AnatomicalEntity	proximal phalanx of pedal digit 2	A proximal phalanx that is part of a pedal digit 2 [Automatically generated definition].	FMA:32618	hp.json	proximal phalanx of second toe|predal digit 2 proximal phalanx|proximal phalanx of foot digit 2|second proximal phalanx of foot|proximal phalanx of the 2nd toe|proximal phalanx of 2nd toe|proximal phalanx of second digit of foot|foot digit 2 proximal phalanx|pedal phalanx II-1|proximal phalanx of pedal digit II|2nd toe proximal phalanx	http://purl.obolibrary.org/obo/UBERON_0004333		pheno_slim
UBERON:0004318	biolink:AnatomicalEntity	distal phalanx of pedal digit 4	A distal phalanx that is part of a foot digit 4 [Automatically generated definition].	FMA:32630	hp.json	distal phalanx of pedal digit IV|distal phalanx of fourth toe|fourth distal phalanx of foot|distal phalanx of the 4th toe|distal phalanx of foot digit 4|distal phalanx of 4th toe|distal phalanx of fourth digit of foot|foot digit 4 distal phalanx|4th toe distal phalanx	http://purl.obolibrary.org/obo/UBERON_0004318		pheno_slim
UBERON:0004319	biolink:AnatomicalEntity	distal phalanx of pedal digit 5	A distal phalanx that is part of a foot digit 5 [Automatically generated definition].	FMA:32631	hp.json	distal phalanx of fifth digit of foot|fifth distal phalanx of foot|distal phalanx of foot digit 5|distal phalanx of the 5th toe|distal phalanx of 5th toe|distal phalanx of little toe|distal phalanx of fifth toe|foot digit 5 distal phalanx|distal phalanx of pedal digit V|5th toe distal phalanx	http://purl.obolibrary.org/obo/UBERON_0004319		pheno_slim
UBERON:0004320	biolink:AnatomicalEntity	middle phalanx of manual digit 2	A middle phalanx that is part of a hand digit 2 [Automatically generated definition].	FMA:23933	hp.json	hand digit 2 middle phalanx|middle phalanx of second finger|2nd finger middle phalanx|second finger intermediate phalanx|intermediate phalanx of second finger|intermediate phalanx of 2nd finger|second middle phalanx of hand|second finger middle phalanx|middle phalanx of second digit of hand|intermediate phalanx of hand digit 2|middle phalanx of 2nd finger|middle phalanx of 2nd digit of hand|middle phalanx of index finger|2nd digit of hand intermediate phalanx|hand digit 2 intermediate phalanx|middle phalanx of manual digit II|intermediate phalanx of 2nd digit of hand|2nd finger intermediate phalanx|2nd digit of hand middle phalanx	http://purl.obolibrary.org/obo/UBERON_0004320		pheno_slim
CHEBI:35950	biolink:ChemicalSubstance	4-oxo monocarboxylic acid			hp.json	4-oxo acid|4-oxo monocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_35950		3_STAR
UBERON:0004327	biolink:AnatomicalEntity	middle phalanx of pedal digit 5	A middle phalanx that is part of a pedal digit 5 [Automatically generated definition].	FMA:230984	hp.json	foot digit 5 intermediate phalanx|5th toe intermediate phalanx|middle phalanx of the 5th toe|middle phalanx of 5th toe|foot digit 5 middle phalanx|intermediate phalanx of foot digit 5|5th toe middle phalanx|intermediate phalanx of 5th toe|middle phalanx of foot digit 5|middle phalanx of little toe|middle phalanx of pedal digit V	http://purl.obolibrary.org/obo/UBERON_0004327		pheno_slim
UBERON:0004328	biolink:AnatomicalEntity	proximal phalanx of manual digit 2	A proximal phalanx that is part of a hand digit 2 [Automatically generated definition].	FMA:23919	hp.json	proximal phalanx of index finger|proximal phalanx of 2nd digit of hand|2nd finger proximal phalanx|manual digit 2 proximal phalanx|proximal phalanx of manual digit II|second finger proximal phalanx|proximal phalanx of 2nd finger|proximal phalanx of second finger|manual phalanx II-1|second proximal phalanx of hand|proximal phalanx of second digit of hand|2nd digit of hand proximal phalanx|hand digit 2 proximal phalanx	http://purl.obolibrary.org/obo/UBERON_0004328		pheno_slim
UBERON:0004325	biolink:AnatomicalEntity	middle phalanx of pedal digit 3	A middle phalanx that is part of a foot digit 3 [Automatically generated definition].	FMA:32624	hp.json	hindlimb short pastern bone|foot digit 3 middle phalanx|3rd toe middle phalanx|middle phalanx of third digit of foot|middle phalanx of the 3rd toe|middle phalanx of 3rd toe|intermediate phalanx of foot digit 3|hindlimb digit III P2|middle phalanx of pedal digit III|intermediate phalanx of 3rd toe|third middle phalanx of foot|middle phalanx of foot digit 3|foot digit 3 intermediate phalanx|middle phalanx of third toe|3rd toe intermediate phalanx	http://purl.obolibrary.org/obo/UBERON_0004325		pheno_slim
UBERON:0004326	biolink:AnatomicalEntity	middle phalanx of pedal digit 4	A middle phalanx that is part of a pedal digit 4 [Automatically generated definition].	FMA:32625	hp.json	foot digit 4 intermediate phalanx|fourth middle phalanx of foot|4th toe intermediate phalanx|foot digit 4 middle phalanx|middle phalanx of the 4th toe|middle phalanx of 4th toe|4th toe middle phalanx|middle phalanx of fourth digit of foot|middle phalanx of fourth toe|intermediate phalanx of foot digit 4|middle phalanx of pedal digit IV|intermediate phalanx of 4th toe|middle phalanx of foot digit 4	http://purl.obolibrary.org/obo/UBERON_0004326		pheno_slim
UBERON:0004323	biolink:AnatomicalEntity	middle phalanx of manual digit 5	A middle phalanx that is part of a hand digit 5 [Automatically generated definition].	FMA:23936	hp.json	5th finger intermediate phalanx|hand digit 5 intermediate phalanx|fifth finger intermediate phalanx|5th digit of hand middle phalanx|middle phalanx of little finger|5th finger middle phalanx|middle phalanx of manual digit V|hand digit 5 middle phalanx|intermediate phalanx of fifth finger|middle phalanx of fifth digit of hand|intermediate phalanx of hand digit 5|fifth finger middle phalanx|intermediate phalanx of 5th finger|middle phalanx of fifth finger|middle phalanx of 5th digit of hand|middle phalanx of 5th finger|intermediate phalanx of 5th digit of hand|fifth middle phalanx of hand|5th digit of hand intermediate phalanx	http://purl.obolibrary.org/obo/UBERON_0004323		pheno_slim
UBERON:0004324	biolink:AnatomicalEntity	middle phalanx of pedal digit 2	A middle phalanx that is part of a foot digit 2 [Automatically generated definition].	FMA:32623	hp.json	foot digit 2 middle phalanx|2nd toe intermediate phalanx|middle phalanx of second toe|middle phalanx of the 2nd toe|middle phalanx of 2nd toe|2nd toe middle phalanx|middle phalanx of pedal digit II|second middle phalanx of foot|intermediate phalanx of 2nd toe|middle phalanx of second digit of foot|intermediate phalanx of foot digit 2|foot digit 2 intermediate phalanx|middle phalanx of foot digit 2	http://purl.obolibrary.org/obo/UBERON_0004324		pheno_slim
UBERON:0004321	biolink:AnatomicalEntity	middle phalanx of manual digit 3	A middle phalanx that is part of a hand digit 3 [Automatically generated definition].	FMA:23934	hp.json	intermediate phalanx of 3rd digit of hand|third finger intermediate phalanx|middle phalanx of manual digit III|middle phalanx of middle finger|middle phalanx of third digit of hand|hand digit 3 middle phalanx|intermediate phalanx of 3rd finger|3rd finger intermediate phalanx|forelimb short pastern bone|intermediate phalanx of third finger|third finger middle phalanx|middle phalanx of 3rd finger|intermediate phalanx of hand digit 3|3rd finger middle phalanx|middle phalanx of third finger|3rd digit of hand intermediate phalanx|third middle phalanx of hand|middle phalanx of 3rd digit of hand|forelimb digit III P2|3rd digit of hand middle phalanx|hand digit 3 intermediate phalanx	http://purl.obolibrary.org/obo/UBERON_0004321		pheno_slim
UBERON:0006984	biolink:AnatomicalEntity	anatomical surface	A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n.	EHDAA2_RETIRED:0003192|NCIT:C34022|FMA:24137|CARO:0001002|BILA:0000010|UMLS:C1515977	hp.json		http://purl.obolibrary.org/obo/UBERON_0006984		upper_level
UBERON:0004322	biolink:AnatomicalEntity	middle phalanx of manual digit 4	A middle phalanx that is part of a hand digit 4 [Automatically generated definition].	FMA:23935	hp.json	4th finger intermediate phalanx|4th digit of hand middle phalanx|middle phalanx of manual digit IV|fourth finger middle phalanx|hand digit 4 middle phalanx|middle phalanx of fourth digit of hand|4th finger middle phalanx|intermediate phalanx of 4th finger|intermediate phalanx of hand digit 4|middle phalanx of fourth finger|middle phalanx of 4th digit of hand|middle phalanx of 4th finger|intermediate phalanx of fourth finger|4th digit of hand intermediate phalanx|intermediate phalanx of 4th digit of hand|middle phalanx of ring finger|fourth finger intermediate phalanx|fourth middle phalanx of hand|hand digit 4 intermediate phalanx	http://purl.obolibrary.org/obo/UBERON_0004322		pheno_slim
UBERON:0006983	biolink:AnatomicalEntity	anatomical point	Non-material anatomical entity of zero dimension, which forms a boundary of an anatomical line or surface.	EHDAA2:0003009|BILA:0000009|AEO:0000009|CARO:0000009|AAO:0010266|TAO:0001839|FMA:9658	hp.json		http://purl.obolibrary.org/obo/UBERON_0006983		upper_level
RO:0002180	biolink:NamedThing	has component	w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.	RO:0002180	hp.json		http://purl.obolibrary.org/obo/RO_0002180		ro-eco
CHEBI:23981	biolink:ChemicalSubstance	ethanolamines			hp.json	ethanolamine	http://purl.obolibrary.org/obo/CHEBI_23981		3_STAR
CHEBI:33306	biolink:ChemicalSubstance	carbon group element atom			hp.json	group IV elements|carbon group element|group 14 elements|cristallogenes|cristallogene|carbonoides|carbon group elements	http://purl.obolibrary.org/obo/CHEBI_33306		3_STAR
CHEBI:35969	biolink:ChemicalSubstance	3-hydroxy monocarboxylic acid	A hydroxy monocarboxylic acid that has a hydroxy group beta to the carboxy group.		hp.json	beta-hydroxy acid|beta-hydroxy carboxylic acids|3-hydroxy monocarboxylic acids|3-hydroxy acid|beta-hydroxy carboxylic acid|beta-hydroxy acids	http://purl.obolibrary.org/obo/CHEBI_35969		3_STAR
CHEBI:33308	biolink:ChemicalSubstance	carboxylic ester	An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl.	KEGG:C02391|Wikipedia:Ester	hp.json	carboxylic acid esters|a carboxylic ester|Carboxylic ester|carboxylic esters	http://purl.obolibrary.org/obo/CHEBI_33308		3_STAR
CHEBI:33300	biolink:ChemicalSubstance	pnictogen	Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth.		hp.json	group 15 elements|group V elements|nitrogenoides|pnictogenes|nitrogenoideos|pnictogene|pnictogens	http://purl.obolibrary.org/obo/CHEBI_33300		3_STAR
PATO:0002257	biolink:NamedThing	multicuspidate	A cuscpidate quality inhering in a bearer by virtue of the bearer possessing more than one cusp.		hp.json		http://purl.obolibrary.org/obo/PATO_0002257		value_slim
CHEBI:33302	biolink:ChemicalSubstance	pnictogen molecular entity	A p-block molecular entity containing any pnictogen.		hp.json	pnictogen molecular entities|pnictogen molecular entity	http://purl.obolibrary.org/obo/CHEBI_33302		3_STAR
PATO:0002254	biolink:NamedThing	flattened	A quality inhering in a bearer by virtue of the bearer's surface becoming more extended in a plane.		hp.json	compressed	http://purl.obolibrary.org/obo/PATO_0002254		value_slim
CHEBI:33303	biolink:ChemicalSubstance	chalcogen	Any p-block element belonging to the group 16 family of the periodic table.	PMID:17084588|PMID:17084588	hp.json	chalcogen|anfigenos|group VI elements|chalcogenes|group 16 elements|chalcogene|chalcogens|anfigeno|Chalkogen|calcogenos|calcogeno|Chalkogene	http://purl.obolibrary.org/obo/CHEBI_33303		3_STAR
PATO:0002255	biolink:NamedThing	grooved	Texture quality inhering in a bearer by virtue of the bearer's being marked with one or more channels.		hp.json	channeled|creased	http://purl.obolibrary.org/obo/PATO_0002255		value_slim
CHEBI:33304	biolink:ChemicalSubstance	chalcogen molecular entity	Any p-block molecular entity containing a chalcogen.		hp.json	chalcogen molecular entity|chalcogen molecular entities|chalcogen compounds	http://purl.obolibrary.org/obo/CHEBI_33304		3_STAR
UBERON:0004316	biolink:AnatomicalEntity	distal phalanx of pedal digit 2	A distal phalanx that is part of a foot digit 2 [Automatically generated definition].	FMA:32628	hp.json	distal phalanx of second toe|distal phalanx of the 2nd toe|distal phalanx of 2nd toe|second distal phalanx of foot|distal phalanx of foot digit 2|distal phalanx of second digit of foot|foot digit 2 distal phalanx|2nd toe distal phalanx|distal phalanx of pedal digit II	http://purl.obolibrary.org/obo/UBERON_0004316		pheno_slim
UBERON:0004317	biolink:AnatomicalEntity	distal phalanx of pedal digit 3	A distal phalanx that is part of a foot digit 3 [Automatically generated definition].	FMA:32629	hp.json	distal phalanx of third toe|distal phalanx of foot digit 3|hindlimb medial ungual phalanx of artiodactyl|hindlimb pedal bone|distal phalanx of the 3rd toe|distal phalanx of 3rd toe|third distal phalanx of foot|distal phalanx of third digit of foot|hindlimb medial claw of artiodactyl|foot digit 3 distal phalanx|3rd toe distal phalanx|distal phalanx of pedal digit III|hindlimb coffin bone|equine hindlimb distal phalanx|equine 3rd phalanx of hindlimb digit 3|hindlimb medial claw of ruminant hoof	http://purl.obolibrary.org/obo/UBERON_0004317		pheno_slim
UBERON:0004314	biolink:AnatomicalEntity	distal phalanx of manual digit 5	A distal phalanx that is part of a hand digit 5 [Automatically generated definition].	FMA:23949	hp.json	distal phalanx of 5th finger|fifth distal phalanx of hand|distal phalanx of fifth digit of hand|distal phalanx of 5th digit of hand|5th digit of hand distal phalanx|5th finger distal phalanx|hand digit 5 distal phalanx|distal phalanx of manual digit V|fifth finger distal phalanx|distal phalanx of little finger|distal phalanx of fifth finger	http://purl.obolibrary.org/obo/UBERON_0004314		pheno_slim
UBERON:0004315	biolink:AnatomicalEntity	distal phalanx of pedal digit 1	A distal phalanx that is part of a foot digit 1 [Automatically generated definition].	FMA:32627	hp.json	distal phalanx of foot digit 1|distal phalanx of hallux|foot digit 1 distal phalanx|hallux distal phalanx|distal phalanx of big toe|distal phalanx of great toe|distal phalanx of pedal digit I|distal phalanx of first digit of foot|first distal phalanx of foot	http://purl.obolibrary.org/obo/UBERON_0004315		pheno_slim
UBERON:0004312	biolink:AnatomicalEntity	distal phalanx of manual digit 3	A distal phalanx that is part of a hand digit 3 [Automatically generated definition].	FMA:23947	hp.json	forelimb medial claw of ruminant hoof|distal phalanx of third digit of hand|third distal phalanx of hand|3rd digit of hand distal phalanx|forelimb coffin bone|equine 3rd phalanx of forelimb digit 3|forelimb medial ungual phalanx of artiodactyl|distal phalanx of manual digit III|hand digit 3 distal phalanx|forelimb pedal bone|distal phalanx of 3rd digit of hand|distal phalanx of middle finger|third finger distal phalanx|distal phalanx of 3rd finger|forelimb medial claw of artiodactyl|3rd finger distal phalanx|distal phalanx of third finger|equine forelimb distal phalanx	http://purl.obolibrary.org/obo/UBERON_0004312		pheno_slim
UBERON:0004313	biolink:AnatomicalEntity	distal phalanx of manual digit 4	A distal phalanx that is part of a hand digit 4 [Automatically generated definition].	FMA:23948	hp.json	distal phalanx of fourth finger|fourth distal phalanx of hand|4th digit of hand distal phalanx|distal phalanx of ring finger|distal phalanx of 4th digit of hand|fourth finger distal phalanx|hand digit 4 distal phalanx|4th finger distal phalanx|distal phalanx of fourth digit of hand|distal phalanx of manual digit IV|distal phalanx of 4th finger	http://purl.obolibrary.org/obo/UBERON_0004313		pheno_slim
UBERON:0004311	biolink:AnatomicalEntity	distal phalanx of manual digit 2	A distal phalanx that is part of a hand digit 2 [Automatically generated definition].	FMA:23946	hp.json	distal phalanx of second digit of hand|distal phalanx of index finger|2nd digit of hand distal phalanx|hand digit 2 distal phalanx|distal phalanx of 2nd digit of hand|2nd finger distal phalanx|distal phalanx of manual digit II|second distal phalanx of hand|second finger distal phalanx|distal phalanx of 2nd finger|distal phalanx of second finger	http://purl.obolibrary.org/obo/UBERON_0004311		pheno_slim
GO:0030258	biolink:BiologicalProcess	lipid modification	The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid.		hp.json		http://purl.obolibrary.org/obo/GO_0030258		
RO:0002297	biolink:NamedThing	results in formation of		RO:0002297	hp.json		http://purl.obolibrary.org/obo/RO_0002297		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
PATO:0000004	biolink:NamedThing	mobility	A quality of inhering in a bearer by virtue of the bearer's disposition to move freely.		hp.json		http://purl.obolibrary.org/obo/PATO_0000004		scalar_slim|disposition_slim|attribute_slim
RO:0002298	biolink:NamedThing	results in morphogenesis of	The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state.	RO:0002298	hp.json		http://purl.obolibrary.org/obo/RO_0002298		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
RO:0002299	biolink:NamedThing	results in maturation of	The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity.	RO:0002299	hp.json		http://purl.obolibrary.org/obo/RO_0002299		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
GO:0042246	biolink:BiologicalProcess	tissue regeneration	The regrowth of lost or destroyed tissues.		hp.json		http://purl.obolibrary.org/obo/GO_0042246		
RO:0002295	biolink:NamedThing	results in developmental progression of	p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).	RO:0002295	hp.json		http://purl.obolibrary.org/obo/RO_0002295		
RO:0002296	biolink:NamedThing	results in development of	p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state.	RO:0002296	hp.json		http://purl.obolibrary.org/obo/RO_0002296		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
PATO:0000001	biolink:NamedThing	quality	A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities		hp.json		http://purl.obolibrary.org/obo/PATO_0000001		
GO:0030252	biolink:BiologicalProcess	growth hormone secretion	The regulated release of growth hormone from secretory granules into the blood.		hp.json	somatotropin secretion	http://purl.obolibrary.org/obo/GO_0030252		
GO:0030246	biolink:MolecularActivity	carbohydrate binding	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.		hp.json	selectin|sugar binding	http://purl.obolibrary.org/obo/GO_0030246		goslim_agr|goslim_pir|goslim_plant|goslim_flybase_ribbon|goslim_drosophila|goslim_metagenomics|goslim_chembl
GO:0030247	biolink:MolecularActivity	polysaccharide binding	Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.		hp.json	polysaccharide assembly with MHC class II protein complex	http://purl.obolibrary.org/obo/GO_0030247		
GO:0042255	biolink:BiologicalProcess	ribosome assembly	The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.		hp.json	ribosomal subunit assembly	http://purl.obolibrary.org/obo/GO_0042255		goslim_yeast
RO:0002286	biolink:NamedThing	developmentally succeeded by	Inverse of developmentally preceded by		hp.json		http://purl.obolibrary.org/obo/RO_0002286		
GO:0042254	biolink:BiologicalProcess	ribosome biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.		hp.json	ribosome biogenesis and assembly	http://purl.obolibrary.org/obo/GO_0042254		goslim_pombe|goslim_pir|goslim_drosophila|goslim_chembl|goslim_aspergillus|goslim_generic|goslim_candida
PATO:0000014	biolink:NamedThing	color	A composite chromatic quality composed of hue, saturation and intensity parts.		hp.json	colour|relative color	http://purl.obolibrary.org/obo/PATO_0000014		attribute_slim
RO:0002287	biolink:NamedThing	part of developmental precursor of			hp.json		http://purl.obolibrary.org/obo/RO_0002287		
PATO:0000017	biolink:NamedThing	color saturation	A scalar chromatic property that is the degree of purity of perceived light.		hp.json		http://purl.obolibrary.org/obo/PATO_0000017		attribute_slim
PATO:0000016	biolink:NamedThing	color brightness	A scalar optical property that is the intensity, value or amount of perceived light.		hp.json	color intensity|color value|color lightness	http://purl.obolibrary.org/obo/PATO_0000016		attribute_slim
RO:0002285	biolink:NamedThing	developmentally replaces	x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else	RO:0002285	hp.json		http://purl.obolibrary.org/obo/RO_0002285		
OBO:cl#lacks_part	biolink:NamedThing	lacks_part			hp.json		http://purl.obolibrary.org/obo/cl#lacks_part		
GO:0030239	biolink:BiologicalProcess	myofibril assembly	Formation of myofibrils, the repeating units of striated muscle.		hp.json		http://purl.obolibrary.org/obo/GO_0030239		
PATO:0000025	biolink:NamedThing	composition	A single physical entity inhering in an bearer by virtue of the bearer's quantities or relative ratios of subparts.		hp.json	content|compositionality|composed of|structure, composition	http://purl.obolibrary.org/obo/PATO_0000025		scalar_slim|attribute_slim
GO:0032892	biolink:BiologicalProcess	positive regulation of organic acid transport	Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	upregulation of organic acid transport|up regulation of organic acid transport|stimulation of organic acid transport|up-regulation of organic acid transport|activation of organic acid transport	http://purl.obolibrary.org/obo/GO_0032892		
GO:0032891	biolink:BiologicalProcess	negative regulation of organic acid transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	down regulation of organic acid transport|inhibition of organic acid transport|down-regulation of organic acid transport|downregulation of organic acid transport	http://purl.obolibrary.org/obo/GO_0032891		
GO:0032890	biolink:BiologicalProcess	regulation of organic acid transport	Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0032890		
GO:0030224	biolink:BiologicalProcess	monocyte differentiation	The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.		hp.json	monocyte cell differentiation	http://purl.obolibrary.org/obo/GO_0030224		
GO:0032886	biolink:BiologicalProcess	regulation of microtubule-based process	Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.		hp.json		http://purl.obolibrary.org/obo/GO_0032886		
GO:0030225	biolink:BiologicalProcess	macrophage differentiation	The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.		hp.json	macrophage cell differentiation	http://purl.obolibrary.org/obo/GO_0030225		
RO:0002264	biolink:NamedThing	acts upstream of or within	c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process.		hp.json	affects	http://purl.obolibrary.org/obo/RO_0002264		http://purl.obolibrary.org/obo/valid_for_go_gp2term
GO:0042277	biolink:MolecularActivity	peptide binding	Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds.		hp.json		http://purl.obolibrary.org/obo/GO_0042277		goslim_chembl|goslim_pir
RO:0002263	biolink:NamedThing	acts upstream of	c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes.		hp.json		http://purl.obolibrary.org/obo/RO_0002263		http://purl.obolibrary.org/obo/valid_for_go_gp2term
PATO:0000033	biolink:NamedThing	concentration of	A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance.		hp.json	concentration	http://purl.obolibrary.org/obo/PATO_0000033		relational_slim|attribute_slim|scalar_slim
RO:0002257	biolink:NamedThing	developmentally induces	Inverse of developmentally induced by		hp.json		http://purl.obolibrary.org/obo/RO_0002257		
RO:0002258	biolink:NamedThing	developmentally preceded by	Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p		hp.json		http://purl.obolibrary.org/obo/RO_0002258		
GO:0032885	biolink:BiologicalProcess	regulation of polysaccharide biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.		hp.json		http://purl.obolibrary.org/obo/GO_0032885		
GO:0030223	biolink:BiologicalProcess	neutrophil differentiation	The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.		hp.json	neutrophil granulocyte differentiation|neutrophil cell differentiation|neutrophil granulocytopoiesis	http://purl.obolibrary.org/obo/GO_0030223		
GO:0032881	biolink:BiologicalProcess	regulation of polysaccharide metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides.		hp.json		http://purl.obolibrary.org/obo/GO_0032881		
GO:0032880	biolink:BiologicalProcess	regulation of protein localization	Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.		hp.json	regulation of protein localisation|regulation of cellular protein localization|regulation of cellular protein localisation	http://purl.obolibrary.org/obo/GO_0032880		goslim_chembl
GO:0030219	biolink:BiologicalProcess	megakaryocyte differentiation	The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.		hp.json	megakaryocyte cell differentiation	http://purl.obolibrary.org/obo/GO_0030219		
GO:0030217	biolink:BiologicalProcess	T cell differentiation	The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.		hp.json	T cell development|T-cell differentiation|T lymphocyte differentiation|T-lymphocyte differentiation	http://purl.obolibrary.org/obo/GO_0030217		
GO:0030218	biolink:BiologicalProcess	erythrocyte differentiation	The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.	Wikipedia:Erythropoiesis	hp.json	erythropoiesis|erythrocyte cell differentiation|red blood cell differentiation|RBC differentiation	http://purl.obolibrary.org/obo/GO_0030218		
GO:0032879	biolink:BiologicalProcess	regulation of localization	Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.		hp.json	regulation of localisation	http://purl.obolibrary.org/obo/GO_0032879		
GO:0032878	biolink:BiologicalProcess	regulation of establishment or maintenance of cell polarity	Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.		hp.json		http://purl.obolibrary.org/obo/GO_0032878		
GO:0030216	biolink:BiologicalProcess	keratinocyte differentiation	The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.		hp.json	keratinocyte cell differentiation	http://purl.obolibrary.org/obo/GO_0030216		
GO:0030213	biolink:BiologicalProcess	hyaluronan biosynthetic process	The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.		hp.json	hyaluronan anabolism|hyaluronan synthesis|hyaluronan biosynthesis|hyaluronan formation	http://purl.obolibrary.org/obo/GO_0030213		
RO:0002254	biolink:NamedThing	has developmental contribution from	x has developmental contribution from y iff x has some part z such that z develops from y	RO:0002254	hp.json		http://purl.obolibrary.org/obo/RO_0002254		
RO:0002255	biolink:NamedThing	developmentally contributes to	inverse of has developmental contribution from	RO:0002255	hp.json		http://purl.obolibrary.org/obo/RO_0002255		http://purl.obolibrary.org/obo/RO_0002259
RO:0002256	biolink:NamedThing	developmentally induced by	t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T.	RO:0002256	hp.json		http://purl.obolibrary.org/obo/RO_0002256		
GO:0030212	biolink:BiologicalProcess	hyaluronan metabolic process	The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.		hp.json	hyaluronan metabolism	http://purl.obolibrary.org/obo/GO_0030212		
GO:0032871	biolink:BiologicalProcess	regulation of karyogamy	Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion.		hp.json		http://purl.obolibrary.org/obo/GO_0032871		
GO:0032870	biolink:BiologicalProcess	cellular response to hormone stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0032870		
GO:0030203	biolink:BiologicalProcess	glycosaminoglycan metabolic process	The chemical reactions and pathways involving glycosaminoglycans, any of a group of polysaccharides that contain amino sugars.		hp.json	glycosaminoglycan metabolism	http://purl.obolibrary.org/obo/GO_0030203		
RO:0002231	biolink:NamedThing	has start location	x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y	RO:0002231	hp.json		http://purl.obolibrary.org/obo/RO_0002231		ro-eco
RO:0002232	biolink:NamedThing	has end location	x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y	RO:0002232	hp.json		http://purl.obolibrary.org/obo/RO_0002232		ro-eco
RO:0002233	biolink:NamedThing	has input	p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.	RO:0002233	hp.json		http://purl.obolibrary.org/obo/RO_0002233		ro-eco|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_ontology
RO:0002234	biolink:NamedThing	has output	p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p.	RO:0002234	hp.json		http://purl.obolibrary.org/obo/RO_0002234		ro-eco|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_ontology
RO:0002230	biolink:NamedThing	ends with	x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.	RO:0002230	hp.json		http://purl.obolibrary.org/obo/RO_0002230		ro-eco
RO:0002229	biolink:NamedThing	ends	Relation between occurrents, shares an end boundary with.	RO:0002229	hp.json	finishes	http://purl.obolibrary.org/obo/RO_0002229		ro-eco
RO:0002224	biolink:NamedThing	starts with	x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.	RO:0002224	hp.json		http://purl.obolibrary.org/obo/RO_0002224		ro-eco
RO:0002225	biolink:NamedThing	develops from part of	x develops from part of y if and only if there exists some z such that x develops from z and z is part of y	RO:0002225	hp.json		http://purl.obolibrary.org/obo/RO_0002225		
RO:0002226	biolink:NamedThing	develops in	x develops_in y if x is located in y whilst x is developing	RO:0002226	hp.json		http://purl.obolibrary.org/obo/RO_0002226		
RO:0002220	biolink:NamedThing	adjacent to	x adjacent to y if and only if x and y share a boundary.	RO:0002220	hp.json		http://purl.obolibrary.org/obo/RO_0002220		http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_ontology
RO:0002221	biolink:NamedThing	surrounds	inverse of surrounded_by	RO:0002221	hp.json		http://purl.obolibrary.org/obo/RO_0002221		http://purl.obolibrary.org/obo/RO_0002259
RO:0002222	biolink:NamedThing	temporally related to			hp.json		http://purl.obolibrary.org/obo/RO_0002222		ro-eco
RO:0002223	biolink:NamedThing	starts	Relation between occurrents, shares a start boundary with.	RO:0002223	hp.json		http://purl.obolibrary.org/obo/RO_0002223		ro-eco
RO:0002219	biolink:NamedThing	surrounded by	x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y	RO:0002219	hp.json		http://purl.obolibrary.org/obo/RO_0002219		
RO:0002213	biolink:NamedThing	positively regulates	Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.	RO:0002213	hp.json		http://purl.obolibrary.org/obo/RO_0002213		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_gp2term
RO:0002215	biolink:Protein	capable_of	A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. 	RO:0002215	hp.json		http://purl.obolibrary.org/obo/RO_0002215		ro-eco|ro-eco
RO:0002216	biolink:NamedThing	capable of part of	c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p.	RO:0002216	hp.json		http://purl.obolibrary.org/obo/RO_0002216		
GO:0019882	biolink:BiologicalProcess	antigen processing and presentation	The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.	Wikipedia:Antigen_presentation	hp.json	antigen processing|antigen presentation	http://purl.obolibrary.org/obo/GO_0019882		
HP:0100886	biolink:PhenotypicFeature	Abnormality of globe location	An abnormality in the placement of the ocular globe (eyeball).	UMLS:C4021946	hp.json	Abnormality of globe position|Abnormality of eyeball position|Abnormality of eyeball location	http://purl.obolibrary.org/obo/HP_0100886		
HP:0100887	biolink:PhenotypicFeature	Abnormality of globe size	An abnormality in the size of the ocular globe (eyeball).	UMLS:C4021945	hp.json	Abnormality of eyeball size|Eye size difference	http://purl.obolibrary.org/obo/HP_0100887		
HP:0100884	biolink:PhenotypicFeature	Compensatory scoliosis	A scoliosis which is the results of a difference in leg length (which might be due to hemihypertrophy or hemihypotrophy of a leg) and the resulting tilting of the pelvis. If untreated this will lead to the development of scoliosis over time.	UMLS:C0343292|SNOMEDCT_US:203645000	hp.json		http://purl.obolibrary.org/obo/HP_0100884		
HP:0100885	biolink:PhenotypicFeature	Lateral venous anomaly	Persistence of the embryonic dorsal or sciatic vein system that normally should have involuted around the tenth to twelfth week of intrauterine life.	UMLS:C4020945	hp.json	Vein of servelle|Lateral marginal vein of Servelle	http://purl.obolibrary.org/obo/HP_0100885		
HP:0100882	biolink:PhenotypicFeature	Fibrous hamartoma	A rare, benign soft tissue tumor that typically occurs within the first two years of life.	SNOMEDCT_US:22257004|UMLS:C0265979|SNOMEDCT_US:56364004	hp.json	Fibrous hamartoma of infancy	http://purl.obolibrary.org/obo/HP_0100882		
HP:0100883	biolink:PhenotypicFeature	Chorangioma	Hamartoma-like growth in the placenta consisting of blood vessels.	SNOMEDCT_US:699948001|SNOMEDCT_US:2099007|MSH:D006391|UMLS:C0677608|SNOMEDCT_US:237268002	hp.json	Placental hamartoma	http://purl.obolibrary.org/obo/HP_0100883		
HP:0100880	biolink:PhenotypicFeature	Nephrogenic rest	Abnormally persistent clusters of embryonal cells, representing microscopic malformations (dysplasias) of the developing kidney.	SNOMEDCT_US:405933007|UMLS:C1320468	hp.json		http://purl.obolibrary.org/obo/HP_0100880		
HP:0100881	biolink:PhenotypicFeature	Congenital mesoblastic nephroma	Congenital mesoblastic nephroma is a type of kidney tumor that is usually found before birth by ultrasound or within the first 3 months of life. It contains fibroblastic cells (connective tissue cells), and may spread to the other kidney or to nearby tissue.	UMLS:C1332965|MSH:D018201	hp.json		http://purl.obolibrary.org/obo/HP_0100881		
RO:0002210	biolink:NamedThing	directly develops into	inverse of directly develops from		hp.json		http://purl.obolibrary.org/obo/RO_0002210		http://purl.obolibrary.org/obo/RO_0002259
RO:0002211	biolink:NamedThing	regulates	process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.	RO:0002211	hp.json		http://purl.obolibrary.org/obo/RO_0002211		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_gp2term
RO:0002212	biolink:NamedThing	negatively regulates	Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.	RO:0002212	hp.json		http://purl.obolibrary.org/obo/RO_0002212		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_go_gp2term
RO:0002207	biolink:NamedThing	directly develops from	Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y.	RO:0002207	hp.json		http://purl.obolibrary.org/obo/RO_0002207		
RO:0002202	biolink:NamedThing	develops_from	x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y	RO:0002202	hp.json		http://purl.obolibrary.org/obo/RO_0002202		
RO:0002203	biolink:NamedThing	develops into	inverse of develops from	RO:0002203	hp.json		http://purl.obolibrary.org/obo/RO_0002203		http://purl.obolibrary.org/obo/RO_0002259
HP:0100888	biolink:PhenotypicFeature	Interdigital loops		UMLS:C4021944	hp.json		http://purl.obolibrary.org/obo/HP_0100888		
HP:0100889	biolink:PhenotypicFeature	Abnormality of the ductus choledochus	An abnormality of the Common bile duct, a tube-like anatomic structure in the human gastrointestinal tract, formed by the union of the Common hepatic duct and the Cystic duct from the gall bladder.	UMLS:C4020944	hp.json	Abnormality of the common bile duct	http://purl.obolibrary.org/obo/HP_0100889		
HP:0100898	biolink:PhenotypicFeature	Connective tissue nevi	Connective tissue nevi are hamartomas in which one or several components of the dermis is altered.	MSH:C562737|UMLS:C0334083|SNOMEDCT_US:22858003|SNOMEDCT_US:400091006	hp.json		http://purl.obolibrary.org/obo/HP_0100898		
HP:0100896	biolink:PhenotypicFeature	Rectal polyposis	The presence of multiple rectal hyperplastic/adenomatous polyps.	SNOMEDCT_US:39772007|UMLS:C0034887	hp.json	Rectal polyps|Multiple rectal polyps	http://purl.obolibrary.org/obo/HP_0100896		
HP:0100893	biolink:PhenotypicFeature	Prominent xiphoid process	Increased prominence of the xiphoid process of the sternum.	UMLS:C4020942	hp.json	Prominent xiphisternum	http://purl.obolibrary.org/obo/HP_0100893		
HP:0100894	biolink:PhenotypicFeature	Broad xiphoid process	Increased side-to-side width of the xiphoid process of the sternum.	UMLS:C4020901	hp.json	Broad xiphisternum	http://purl.obolibrary.org/obo/HP_0100894		
HP:0100891	biolink:PhenotypicFeature	Bifid xiphoid process	A cleft of the xiphoid process of the sternum.	UMLS:C4020943	hp.json	Bifid xiphisternum	http://purl.obolibrary.org/obo/HP_0100891		
HP:0100892	biolink:PhenotypicFeature	Abnormality of the xiphoid process	An abnormality of the xiphoid process of the sternum.	UMLS:C4021943	hp.json		http://purl.obolibrary.org/obo/HP_0100892		
HP:0100890	biolink:PhenotypicFeature	Cyst of the ductus choledochus		SNOMEDCT_US:440471007|UMLS:C0008340|SNOMEDCT_US:397868007|SNOMEDCT_US:398197009|MSH:D015529	hp.json	Choledochal cyst	http://purl.obolibrary.org/obo/HP_0100890		
GO:0140734	biolink:BiologicalProcess	ammonium excretion	The elimination of ammonium ions from an excretory cell.		hp.json	ammonia excretion	http://purl.obolibrary.org/obo/GO_0140734		
HP:0100899	biolink:PhenotypicFeature	Sclerosis of finger phalanx	An elevation in bone density in one or more phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020941	hp.json	Increased bone density in the finger bone|Sclerosis of the phalanges of the hand	http://purl.obolibrary.org/obo/HP_0100899		
GO:0044848	biolink:BiologicalProcess	biological phase	A distinct period or stage in a biological process or cycle.		hp.json		http://purl.obolibrary.org/obo/GO_0044848		gocheck_do_not_manually_annotate
UBERON:0018597	biolink:AnatomicalEntity	upper primary canine tooth	A primary canine tooth that is part of a upper jaw region.	FMA:84228	hp.json	upper deciduous canine tooth|upper primary tooth C|deciduous upper canine tooth	http://purl.obolibrary.org/obo/UBERON_0018597		
UBERON:0018598	biolink:AnatomicalEntity	lower primary canine tooth	A primary canine tooth that is part of a lower jaw region.	FMA:84229	hp.json	lower deciduous canine tooth|primary lower canine tooth|lower primary tooth C|deciduous lower canine tooth	http://purl.obolibrary.org/obo/UBERON_0018598		
UBERON:0018595	biolink:AnatomicalEntity	lower central primary incisor tooth	A lower primary incisor tooth that is in_the_central_side_of a dentition.	FMA:84218	hp.json	lower central deciduous incisor tooth|lower primary tooth A|deciduous lower central incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018595		pheno_slim
UBERON:0018596	biolink:AnatomicalEntity	lower lateral primary incisor tooth	A lower primary incisor tooth that is in_the_lateral_side_of a dentition.	FMA:84219	hp.json	lower lateral deciduous incisor tooth|lower primary tooth B|deciduous lower lateral incisor tooth|mandibular lateral primary incisor	http://purl.obolibrary.org/obo/UBERON_0018596		pheno_slim
UBERON:0018593	biolink:AnatomicalEntity	upper central primary incisor tooth	A upper primary canine tooth that is in_the_central_side_of a dentition.	FMA:84216	hp.json	upper central deciduous incisor tooth|upper primary tooth A	http://purl.obolibrary.org/obo/UBERON_0018593		pheno_slim
UBERON:0018594	biolink:AnatomicalEntity	upper lateral primary incisor tooth	A upper primary canine tooth that is in_the_lateral_side_of a dentition.	FMA:84217	hp.json	upper lateral deciduous incisor tooth|upper primary tooth B	http://purl.obolibrary.org/obo/UBERON_0018594		pheno_slim
UBERON:0018591	biolink:AnatomicalEntity	upper primary incisor tooth	A primary incisor tooth that is part of a upper jaw region.	FMA:84214	hp.json	upper deciduous incisor tooth|deciduous upper incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018591		
UBERON:0018599	biolink:AnatomicalEntity	upper second primary molar tooth		FMA:84236	hp.json	upper primary tooth E|upper second deciduous molar tooth	http://purl.obolibrary.org/obo/UBERON_0018599		
OBO:hp#obsolete_synonym	biolink:NamedThing	discarded/obsoleted synonym			hp.json		http://purl.obolibrary.org/obo/hp#obsolete_synonym		
GO:0044877	biolink:MolecularActivity	protein-containing complex binding	Binding to a macromolecular complex.		hp.json	protein complex binding|macromolecular complex binding	http://purl.obolibrary.org/obo/GO_0044877		goslim_chembl
GO:0030282	biolink:BiologicalProcess	bone mineralization	The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.		hp.json	bone calcification	http://purl.obolibrary.org/obo/GO_0030282		
GO:0030279	biolink:BiologicalProcess	negative regulation of ossification	Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.		hp.json	negative regulation of bone biosynthesis|downregulation of ossification|negative regulation of bone formation|down regulation of ossification|inhibition of ossification|down-regulation of ossification	http://purl.obolibrary.org/obo/GO_0030279		
GO:0042221	biolink:BiologicalProcess	response to chemical	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.		hp.json	response to chemical stimulus|response to chemical substance	http://purl.obolibrary.org/obo/GO_0042221		goslim_candida|gocheck_do_not_manually_annotate|goslim_plant|goslim_drosophila|goslim_metagenomics|goslim_aspergillus|goslim_yeast
GO:0030278	biolink:BiologicalProcess	regulation of ossification	Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.		hp.json	regulation of bone formation|regulation of bone biosynthesis	http://purl.obolibrary.org/obo/GO_0030278		
NCBITaxon:862507	biolink:OrganismalEntity	Mus <subgenus>		GC_ID:1	hp.json	Mus	http://purl.obolibrary.org/obo/NCBITaxon_862507		
NCBITaxon:1437010	biolink:OrganismalEntity	Boreoeutheria		PMID:11743200|PMID:11791233|GC_ID:1	hp.json	Boreotheria	http://purl.obolibrary.org/obo/NCBITaxon_1437010		
GO:0030264	biolink:BiologicalProcess	nuclear fragmentation involved in apoptotic nuclear change	The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.		hp.json	nucleus fragmentation|nuclear fragmentation during apoptosis|apoptotic nuclear fragmentation	http://purl.obolibrary.org/obo/GO_0030264		
GO:0030262	biolink:BiologicalProcess	apoptotic nuclear changes	Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis.		hp.json	apoptotic nuclear change	http://purl.obolibrary.org/obo/GO_0030262		
GO:0030263	biolink:BiologicalProcess	apoptotic chromosome condensation	The compaction of chromatin during apoptosis.	Wikipedia:Pyknosis	hp.json	pyknosis	http://purl.obolibrary.org/obo/GO_0030263		
GO:0030261	biolink:BiologicalProcess	chromosome condensation	The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.		hp.json	DNA condensation|eukaryotic chromosome condensation|nuclear chromosome condensation	http://purl.obolibrary.org/obo/GO_0030261		
HP:0100920	biolink:PhenotypicFeature	Sclerosis of 4th finger phalanx	An elevation in bone density in one or more phalanges of the fourth finger. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020935	hp.json	Sclerosis of the phalanges of the 4th finger|Increased bone density in ring finger bone	http://purl.obolibrary.org/obo/HP_0100920		
UBERON:0018664	biolink:AnatomicalEntity	neck of bone element	The neck region of a bone organ.		hp.json	neck of bone|bone neck	http://purl.obolibrary.org/obo/UBERON_0018664		
UBERON:0018667	biolink:AnatomicalEntity	neck of scapula		FMA:23254	hp.json	scapular neck|anatomical neck of scapula|collum scapulae	http://purl.obolibrary.org/obo/UBERON_0018667		
UBERON:0004022	biolink:AnatomicalEntity	germinal neuroepithelium	The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells.		hp.json	germinal neuroepithelium|original neural tube|germinal neuroepithelial layer|germinal neuroepithelial layer	http://purl.obolibrary.org/obo/UBERON_0004022		pheno_slim
HP:0002377	biolink:PhenotypicFeature	obsolete Paraganglioma-related cranial nerve palsy			hp.json		http://purl.obolibrary.org/obo/HP_0002377		
HP:0002378	biolink:PhenotypicFeature	Hand tremor	An unintentional, oscillating to-and-fro muscle movement affecting the hand.	UMLS:C0239842	hp.json	Tremor of hands|Tremor of hand|tremors in hands|Hand tremor	http://purl.obolibrary.org/obo/HP_0002378		
UBERON:0006683	biolink:AnatomicalEntity	posterior fontanelle	A gap between bones in the skull at the junction of the sagittal suture and lambdoidal suture.	EMAPA:19200|FMA:75440	hp.json	fonticulus posterior|occipital fontanelle|posterior fontanelle of skull	http://purl.obolibrary.org/obo/UBERON_0006683		pheno_slim
HP:0002375	biolink:PhenotypicFeature	Hypokinesia	Abnormally diminished motor activity. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.	MSH:D018476|UMLS:C0086439|SNOMEDCT_US:255385008|SNOMEDCT_US:43994002	hp.json	Decreased spontaneous movement|Decreased spontaneous movements|Decreased muscle movement	http://purl.obolibrary.org/obo/HP_0002375		
HP:0002376	biolink:PhenotypicFeature	Developmental regression	Loss of developmental skills, as manifested by loss of developmental milestones.	UMLS:C1855019|SNOMEDCT_US:609225004|UMLS:C1855996|UMLS:C1850493|UMLS:C1859678|UMLS:C1836830|UMLS:C1857121|UMLS:C1836550|UMLS:C1855009	hp.json	Psychomotor regression, progressive|Neurodevelopmental regression|Psychomotor regression in infants|Mental deterioration in childhood|Psychomotor regression|Loss of developmental milestones|Psychomotor regression beginning in infancy	http://purl.obolibrary.org/obo/HP_0002376		
UBERON:0006682	biolink:AnatomicalEntity	hypoglossal canal	The hypoglossal canal is a bony canal in the occipital bone of the skull.	FMA:75370|Wikipedia:Hypoglossal_canal|EMAPA:19012|SCTID:139380001	hp.json	canalis nervi hypoglossi|anterior condylar canal|hyperglossal canal|canalis nervi hypoglossi|hyperglossal canal	http://purl.obolibrary.org/obo/UBERON_0006682		
HP:0100929	biolink:PhenotypicFeature	Sclerosis of 5th toe phalanx	An elevation in bone density in one or more phalanges of the fifth toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020927	hp.json	Increased bone density in little toe bone|Increased bone density in pinky toe bone|Sclerosis of the phalanges of the 5th toe|Increased bone density in pinkie toe bone	http://purl.obolibrary.org/obo/HP_0100929		
HP:0100927	biolink:PhenotypicFeature	Sclerosis of 3rd toe phalanx	An elevation in bone density in one or more phalanges of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020929	hp.json	Increased bone density in 3rd toe bone|Sclerosis of the phalanges of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100927		
HP:0002370	biolink:PhenotypicFeature	Poor coordination		UMLS:C0563243	hp.json	Poor coordination	http://purl.obolibrary.org/obo/HP_0002370		
HP:0100928	biolink:PhenotypicFeature	Sclerosis of 4th toe phalanx	An elevation in bone density in one or more phalanges of the fourth toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020928	hp.json	Sclerosis of the phalanges of the 4th toe|Increased bone density in 4th toe bone	http://purl.obolibrary.org/obo/HP_0100928		
HP:0100925	biolink:PhenotypicFeature	Sclerosis of foot bone	An elevation in bone density in one or more foot bones. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020931	hp.json	Sclerosis of bones of the feet|Increased bone density in foot bone	http://purl.obolibrary.org/obo/HP_0100925		
HP:0100926	biolink:PhenotypicFeature	Sclerosis of 2nd toe phalanx	An elevation in bone density in one or more phalanges of the second toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020930	hp.json	Sclerosis of the phalanges of the 2nd toe|Increased bone density in 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100926		
HP:0100923	biolink:PhenotypicFeature	Clavicular sclerosis	An increase in bone density within the clavicle.	UMLS:C3554669	hp.json	Osteosclerosis of the clavicles|Osteosclerosis of the clavicle|Increased bone density in collarbone	http://purl.obolibrary.org/obo/HP_0100923		
UBERON:0006689	biolink:AnatomicalEntity	frenulum of tongue	A small fold of mucous membrane extending from the floor of the mouth to the midline of the underside of the tongue.	EMAPA:18656|UMLS:C2339893|FMA:54659|NCIT:C87076	hp.json	frenulum linguæ|frenulum of the tongue|lingual frenum|frenulum linguae|frenulum|lingual frenulum|tongue frenulum|frenulum linguae	http://purl.obolibrary.org/obo/UBERON_0006689		pheno_slim
HP:0002373	biolink:PhenotypicFeature	Febrile seizure (within the age range of 3 months to 6 years)	A febrile seizure is any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in children between the ages of 3 months and 6 years.	MSH:D003294|UMLS:C0009952|SNOMEDCT_US:41497008	hp.json	Fever induced seizures|Seizures, febrile, in early childhood|Febrile seizures|Febrile convulsion|Seizures, generalized, associated with fever	http://purl.obolibrary.org/obo/HP_0002373		
HP:0100924	biolink:PhenotypicFeature	Sclerosis of toe phalanx	An elevation in bone density in one or more phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020932	hp.json	Increased bone density in the toe bone|Sclerosis of the phalanges of the toes	http://purl.obolibrary.org/obo/HP_0100924		
UBERON:0004027	biolink:AnatomicalEntity	chorionic plate	That portion of the chorionic wall in the region of its uterine attachment, which gives rise to chorionic villi; it consists of the mesoderm that lines the chorionic vesicle and, on the maternal side, of the trophoblast that lines the intervillous spaces; in the last half of gestation, the mesodermal connective tissue is largely replaced by fibrinoid material, and the amnionic membrane is adherent to the fetal side of the plate.	UMLS:C0230972|SCTID:256391000|BTO:0002879|NCIT:C34123|EMAPA:31872	hp.json		http://purl.obolibrary.org/obo/UBERON_0004027		pheno_slim
HP:0002374	biolink:PhenotypicFeature	Diminished movement		UMLS:C4025710	hp.json	Diminished movement	http://purl.obolibrary.org/obo/HP_0002374		
HP:0100921	biolink:PhenotypicFeature	Sclerosis of 5th finger phalanx	An elevation in bone density in one or more phalanges of the fifth finger. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020934	hp.json	Increased bone density in pinky finger bone|Increased bone density in little finger bone|Sclerosis of the phalanges of the 5th finger|Increased bone density in pinkie finger bone	http://purl.obolibrary.org/obo/HP_0100921		
HP:0002371	biolink:PhenotypicFeature	Loss of speech		UMLS:C0542223	hp.json	Loss of speech	http://purl.obolibrary.org/obo/HP_0002371		
HP:0100922	biolink:PhenotypicFeature	Sclerosis of thumb phalanx		UMLS:C4020933	hp.json	Sclerosis of the phalanges of the thumb|Increased bone density in thumb bone	http://purl.obolibrary.org/obo/HP_0100922		
UBERON:0006686	biolink:AnatomicalEntity	spinal vein	A vein that is part of a vertebral column.	MA:0002108|EMAPA:18255|FMA:76735	hp.json	vena spinalis|spinal branch	http://purl.obolibrary.org/obo/UBERON_0006686		
HP:0002372	biolink:PhenotypicFeature	Normal interictal EEG	Lack of observable abnormal electroencephalographic (EEG) patterns in an individual with a history of seizures. About half of individuals with epilepsy show interictal epileptiform discharges upon the first investigation. The yield can be increased by repeated studies, sleep studies, or by ambulatory EEG recordings over 24 hours. Normal interictal EEG is a sign that can be useful in the differential diagnosis.	UMLS:C1843146	hp.json		http://purl.obolibrary.org/obo/HP_0002372		
HP:0100930	biolink:PhenotypicFeature	Sclerosis of hallux phalanx	An elevation in bone density in one or more phalanges of the big toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020926	hp.json	Sclerosis of the phalanges of the hallux|Increased bone density in big toe bone	http://purl.obolibrary.org/obo/HP_0100930		
HP:0100931	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the 2nd toe	An elevation in bone density in the proximal phalanx of the second toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4021927	hp.json	Increased bone density in the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100931		
UBERON:0006674	biolink:AnatomicalEntity	inguinal ring	An entrance or exit of the inguinal canal.	FMA:65075|EMAPA:29307	hp.json		http://purl.obolibrary.org/obo/UBERON_0006674		pheno_slim
HP:0002389	biolink:PhenotypicFeature	Cavum septum pellucidum	If the two laminae of the septum pellucidum are not fused then a fluid-filled space or cavum is present. The cavum septum pellucidum is present at birth but usually obliterates by the age of 3 to 6 months. It is up to 1cm in width and the walls are parallel. It is an enclosed space and is not part of the ventricular system or connected with the subarachnoid space.	UMLS:C1840380	hp.json	Large cavum septi pellucidi|Widened cavum septum pellucidum|Persistent cavum septum pellucidum	http://purl.obolibrary.org/obo/HP_0002389		
UBERON:0006673	biolink:AnatomicalEntity	mandibular canal	A canal within the mandible that contains the inferior alveolar nerve, inferior alveolar artery, and inferior alveolar vein. It runs obliquely downward and forward in the ramus, and then horizontally forward in the body, where it is placed under the alveoli and communicates with them by small openings.	FMA:59473|EMAPA:19161	hp.json	inferior alveolar canal	http://purl.obolibrary.org/obo/UBERON_0006673		
UBERON:0006671	biolink:AnatomicalEntity	orbital fat pad	A fat pad that is part of a orbital region.	FMA:59005|EMAPA:19152	hp.json	retrobulbar fat|orbital fat|orbital fat body|intraorbital fat pad	http://purl.obolibrary.org/obo/UBERON_0006671		
UBERON:0006670	biolink:AnatomicalEntity	central tendon of diaphragm	The three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers.	NCIT:C34119|Wikipedia:Central_tendon_of_diaphragm|UMLS:C0230162|EMAPA:17702|VHOG:0001399|SCTID:244943002|FMA:58279	hp.json	central tendon|centrum tendineum diaphragmatis|centrum tendineum	http://purl.obolibrary.org/obo/UBERON_0006670		pheno_slim
HP:0100938	biolink:PhenotypicFeature	Sclerosis of the middle phalanx of the 5th toe		UMLS:C4021920	hp.json	Increased bone density in the middle bone of the pinkie toe|Increased bone density in the middle bone of the pinky toe|Increased bone density in the middle bone of the little toe	http://purl.obolibrary.org/obo/HP_0100938		
HP:0002380	biolink:PhenotypicFeature	Fasciculations	Fasciculations are observed as small, local, involuntary muscle contractions (twitching) visible under the skin. Fasciculations result from increased irritability of an axon (which in turn is often a manifestation of disease of a motor neuron). This leads to sporadic discharges of all the muscle fibers controlled by the axon in isolation from other motor units.	SNOMEDCT_US:82470000|MSH:D005207|UMLS:C0015644	hp.json	Muscle twitch|Muscle fasciculation|Fasciculation	http://purl.obolibrary.org/obo/HP_0002380		
HP:0002381	biolink:PhenotypicFeature	Aphasia	An acquired language impairment of some or all of the abilities to produce or comprehend speech and to read or write.	MSH:D001037|UMLS:C0003537|SNOMEDCT_US:87486003	hp.json	Difficulty finding words|Loss of words|Losing words	http://purl.obolibrary.org/obo/HP_0002381		
HP:0100939	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the 2nd toe		UMLS:C4021919	hp.json	Increased bone density in the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100939		
HP:0100936	biolink:PhenotypicFeature	Sclerosis of the middle phalanx of the 3rd toe	An elevation in bone density in the middle phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4021922	hp.json	Increased bone density in the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100936		
HP:0100937	biolink:PhenotypicFeature	Sclerosis of the middle phalanx of the 4th toe		UMLS:C4021921	hp.json	Increased bone density in the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100937		
HP:0002384	biolink:PhenotypicFeature	Focal impaired awareness seizure	Focal impaired awareness seizure (or focal seizure with impaired or lost awareness) is a type of focal-onset seizure characterized by some degree (which may be partial) of impairment of the person's awareness of themselves or their surroundings at any point during the seizure.	UMLS:C0270834|UMLS:C0149958|SNOMEDCT_US:4103001	hp.json	Focal seizures with impairment of consciousness or awareness|Localized dyscognitive seizure|Localised seizure with loss of awareness|Complex partial seizure|Focal seizure with loss of awareness|Localised seizure with impaired awareness|Focal impaired awareness seizures|Dyscognitive seizures|Partial seizure with impairment of awareness|Partial dyscognitive seizure|Localized seizure with loss of awareness|Localised dyscognitive seizure|Complex partial seizures|Localized seizure with impaired awareness|Focal seizure with impairment of awareness|Focal dyscognitive seizure|Complex focal seizures|Partial seizure with loss of awareness	http://purl.obolibrary.org/obo/HP_0002384		
HP:0100934	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the 5th toe		UMLS:C4021924	hp.json	Increased bone density in the innermost bone of the little toe|Increased bone density in the innermost bone of the pinky toe|Increased bone density in the innermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100934		
UBERON:0004015	biolink:AnatomicalEntity	embryonic-extraembryonic boundary	The connection between the embryo proper and extraembryonic tissues.		hp.json		http://purl.obolibrary.org/obo/UBERON_0004015		pheno_slim
HP:0002385	biolink:PhenotypicFeature	Paraparesis	Weakness or partial paralysis in the lower limbs.	MSH:D020335|SNOMEDCT_US:1845001|UMLS:C0221166	hp.json	Partial paralysis of legs	http://purl.obolibrary.org/obo/HP_0002385		
UBERON:0004016	biolink:AnatomicalEntity	dermatome	A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells.	EHDAA:1737|EHDAA:1725|EMAPA:32838|EHDAA:1731|XAO:0000220|NCIT:C61572|AAO:0011028|UMLS:C0180383|FMA:295656|Wikipedia:Dermatome_(embryology)|EHDAA2_RETIRED:0003428|EHDAA:1719|AEO:0001017	hp.json	cutis plate|dermatomal mesenchyme|epimere mesoderm|mesenchyma dermatomiale|mesenchyma dermatomiale|cutis plate|dermatomal mesenchyme	http://purl.obolibrary.org/obo/UBERON_0004016		pheno_slim
UBERON:0006677	biolink:AnatomicalEntity	surface of epithelium	An anatomical boundary that adjacent_to a epithelium.	FMA:70997	hp.json	epithelium surface	http://purl.obolibrary.org/obo/UBERON_0006677		
HP:0100935	biolink:PhenotypicFeature	Sclerosis of the middle phalanx of the 2nd toe		UMLS:C4021923	hp.json	Increased bone density in the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100935		
HP:0100932	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the 3rd toe	An elevation in bone density in the proximal phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4021926	hp.json	Increased bone density in the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100932		
HP:0002383	biolink:PhenotypicFeature	Infectious encephalitis	A disorder of the brain caused by an infectious agent that presents with fever, headache, and an altered level of consciousness. There may also be focal or multifocal neurologic deficits, and focal or generalized seizure activity.	SNOMEDCT_US:45170000|UMLS:C0014038|MSH:D004660	hp.json	Brain inflammation	http://purl.obolibrary.org/obo/HP_0002383		
UBERON:0004014	biolink:AnatomicalEntity	labium minora	One of the folds of skin which form the inner lips on both sides of the vaginal opening.	galen:LabiaMinora|FMA:20374|MA:0002845|NCIT:C12307|UMLS:C0227766	hp.json	labium minus pudendi|labium minus|labium minus pudendi|labia minorum|labium minorum|labium minora	http://purl.obolibrary.org/obo/UBERON_0004014		pheno_slim
HP:0100933	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the 4th toe		UMLS:C4021925	hp.json	Increased bone density in the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100933		
UBERON:0006675	biolink:AnatomicalEntity	venous valve	A valve that is part of a vein.	MESH:D055422|FMA:68095	hp.json	valve of vein	http://purl.obolibrary.org/obo/UBERON_0006675		
HP:0100941	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the 4th toe		UMLS:C4021917	hp.json	Increased bone density in the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100941		
HP:0100942	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the 5th toe		UMLS:C4021916	hp.json	Increased bone density in the outermost bone of the little toe|Increased bone density in the outermost bone of the pinkie toe|Increased bone density in the outermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100942		
HP:0100940	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the 3rd toe	An elevation in bone density in the distal phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4021918	hp.json	Increased bone density in the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100940		
UBERON:0018649	biolink:AnatomicalEntity	cardiac muscle tissue of ventricle		FMA:83450	hp.json	ventricular cardiac muscle tissue|ventricular cardiac muscle tissue|ventricular muscle|ventricular heart muscle|ventricular muscle|ventricular heart muscle	http://purl.obolibrary.org/obo/UBERON_0018649		
UBERON:0018645	biolink:AnatomicalEntity	incisor region of dentition	The subdivision of the dentition that consists entire of incisor teeth.		hp.json	set of incisors	http://purl.obolibrary.org/obo/UBERON_0018645		
UBERON:0018643	biolink:AnatomicalEntity	deciduous molar tooth 2			hp.json	deciduous second molar tooth	http://purl.obolibrary.org/obo/UBERON_0018643		
UBERON:0018644	biolink:AnatomicalEntity	deciduous molar tooth 1			hp.json	deciduous molar 1|first temporarary molar|deciduous first molar tooth	http://purl.obolibrary.org/obo/UBERON_0018644		
HP:0002355	biolink:PhenotypicFeature	Difficulty walking	Reduced ability to walk (ambulate).	SNOMEDCT_US:228158008|MSH:D051346|UMLS:C0311394	hp.json	Difficulty walking|Difficulty in walking|Walking disability	http://purl.obolibrary.org/obo/HP_0002355		
UBERON:0004000	biolink:AnatomicalEntity	tarsal gland acinus	A sac-like structure comprising a sebaceous gland.	EMAPA:37972	hp.json	palpebral gland acinus|Meibomian gland acinus|acinus of tarsal gland	http://purl.obolibrary.org/obo/UBERON_0004000		pheno_slim
HP:0002356	biolink:PhenotypicFeature	Writer's cramp	A focal dystonia of the fingers, hand, and/or forearm that appears when the affected person attempts to do a task that requires fine motor movements such as writing or playing a musical instrument.	UMLS:C0154676|MSH:D020821|SNOMEDCT_US:52008007	hp.json	Writer's cramp	http://purl.obolibrary.org/obo/HP_0002356		
UBERON:0004001	biolink:AnatomicalEntity	olfactory bulb layer		EMAPA:37917|NLXANAT:20090402	hp.json	cytoarchitectural part of olfactory bulb	http://purl.obolibrary.org/obo/UBERON_0004001		pheno_slim
UBERON:0006661	biolink:AnatomicalEntity	epicranial aponeurosis	The galea aponeurotica (epicranial aponeurosis, aponeurosis epicranialis) is a tough layer of dense fibrous tissue which covers the upper part of the cranium; behind, it is attached, in the interval between its union with the Occipitales, to the external occipital protuberance and highest nuchal lines of the occipital bone; in front, it forms a short and narrow prolongation between its union with the Frontales. On either side it gives origin to the Auriculares anterior and superior; in this situation it loses its aponeurotic character, and is continued over the temporal fascia to the zygomatic arch as a layer of laminated areolar tissue. It is closely connected to the integument by the firm, dense, fibro-fatty layer which forms the superficial fascia of the scalp: it is attached to the pericranium by loose cellular tissue, which allows the aponeurosis, carrying with it the integument to move through a considerable distance.	EMAPA:19210|FMA:46768	hp.json	galea aponeurosis|galeal aponeurosis|aponeurosis epicranialis|aponeurosis of epicranius|epicranial aponeurosis|cranial aponeurosis|galea aponeurotica|epicranius aponeurosis|galea aponeurotica; aponeurosis epicranialis|epicranial aponeurosis	http://purl.obolibrary.org/obo/UBERON_0006661		
HP:0002353	biolink:PhenotypicFeature	EEG abnormality	Abnormality observed by electroencephalogram (EEG), which is used to record of the brain's spontaneous electrical activity from multiple electrodes placed on the scalp.	UMLS:C0151611|SNOMEDCT_US:274521009	hp.json	Electroencephalogram abnormal|Abnormal EEG|EEG abnormalities|Abnormal electroencephalogram|Electroencephalogram abnormalities	http://purl.obolibrary.org/obo/HP_0002353		
HP:0002354	biolink:PhenotypicFeature	Memory impairment	An impairment of memory as manifested by a reduced ability to remember things such as dates and names, and increased forgetfulness.	MSH:D008569|SNOMEDCT_US:55533009|UMLS:C0233794|UMLS:C0542476|UMLS:C0751295|SNOMEDCT_US:386807006	hp.json	Forgetfulness|Memory problems|Memory loss|Poor memory|Memory impairment	http://purl.obolibrary.org/obo/HP_0002354		
UBERON:0006660	biolink:AnatomicalEntity	muscular coat	A region of muscle in many organs in the vertebrate body, adjacent to the submucosa membrane. It is responsible for gut movement such as peristalsis.	SCTID:86915006|BTO:0004838|Wikipedia:Muscular_layer|UMLS:C0225358	hp.json	transverse muscular fibers|muscular layer|muscularis propria|tunica muscularis|muscular coat|transverse muscular fibers|tunica externa|muscularis externa|tunica muscularis|muscularis propria|tunica muscularis|muscular coat|muscularis layer|muscularis	http://purl.obolibrary.org/obo/UBERON_0006660		
HP:0002359	biolink:PhenotypicFeature	Frequent falls		UMLS:C0850703	hp.json	Frequent falls	http://purl.obolibrary.org/obo/HP_0002359		
HP:0002357	biolink:PhenotypicFeature	obsolete Dysphasia			hp.json		http://purl.obolibrary.org/obo/HP_0002357		
UBERON:0004008	biolink:AnatomicalEntity	cerebellar plate	The embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium.	EHDAA2:0004401|DHBA:12698	hp.json	cerebellum plate|cerebellum roof plate	http://purl.obolibrary.org/obo/UBERON_0004008		pheno_slim
HP:0100947	biolink:PhenotypicFeature	Sclerosis of middle toe phalanx	An elevation in bone density in one or more middle phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020924	hp.json	Sclerosis of the middle phalanges of the toes|Increased bone density in middle toe bone	http://purl.obolibrary.org/obo/HP_0100947		
HP:0100948	biolink:PhenotypicFeature	Sclerosis of distal toe phalanx	An elevation in bone density in one or more distal phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020923	hp.json	Sclerosis of the distal phalanges of the toes|Increased bone density in the outermost bone of the toes	http://purl.obolibrary.org/obo/HP_0100948		
UBERON:0006668	biolink:AnatomicalEntity	carotid canal	On the interior surface of the temporal bone, behind the rough surface of the apex, is the large circular aperture of the carotid canal, which ascends at first vertically, and then, making a bend, runs horizontally forward and medialward. It transmits into the cranium, the internal carotid artery, and the carotid plexus of nerves. Sympathetics to the head also pass through the carotid canal. They have several motor functions: raise the eyelid (superior tarsal muscle), dilate pupil, innervate sweat glands of face and scalp and constricts blood vessels in head[WP].	FMA:55805|Wikipedia:Carotid_canal|EMAPA:18707	hp.json	canalis caroticus|canalis caroticus	http://purl.obolibrary.org/obo/UBERON_0006668		
HP:0100945	biolink:PhenotypicFeature	Sclerosis of the 1st metatarsal		UMLS:C4021913	hp.json	Increased bone density in the 1st long bone of foot	http://purl.obolibrary.org/obo/HP_0100945		
HP:0002352	biolink:PhenotypicFeature	Leukoencephalopathy	This term describes abnormality of the white matter of the cerebrum resulting from damage to the myelin sheaths of nerve cells.	SNOMEDCT_US:22811006|UMLS:C0270612|MSH:D056784	hp.json		http://purl.obolibrary.org/obo/HP_0002352		
HP:0100946	biolink:PhenotypicFeature	Sclerosis of proximal toe phalanx	An elevation in bone density in one or more proximal phalanges of the toes. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020925	hp.json	Increased bone density in innermost toe bone|Sclerosis of the proximal phalanges of the toes	http://purl.obolibrary.org/obo/HP_0100946		
HP:0100943	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the hallux		UMLS:C4021915	hp.json	Increased bone density in the innermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0100943		
HP:0002350	biolink:PhenotypicFeature	Cerebellar cyst		UMLS:C1847762	hp.json	Cerebellar cysts	http://purl.obolibrary.org/obo/HP_0002350		
HP:0100944	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the hallux		UMLS:C4021914	hp.json	Increased bone density in the outermost bone of the big toe	http://purl.obolibrary.org/obo/HP_0100944		
UBERON:0006664	biolink:AnatomicalEntity	greater palatine artery	The greater palatine artery is a terminal branch of the maxillary artery. It branches off of the maxillary artery in the pterygopalatine fossa and descends through the greater palatine foramen along with the greater palatine nerve and supplies the hard palate. It also anastomosis through the incisive canal with the sphenopalatine artery to supply the nasal cavity.	EMAPA:18754|FMA:49795|MA:0001993	hp.json	arteria palatina major|major palatine artery	http://purl.obolibrary.org/obo/UBERON_0006664		human_reference_atlas
HP:0100952	biolink:PhenotypicFeature	Enlarged sylvian cistern	An increase in size of the subarachnoid space associated with the lateral cerebral sulcus (Sylvian fissure).	UMLS:C4020921	hp.json	Enlarged lateral fissure|Enlarged lateral sulcus|Enlarged sylvian fissure	http://purl.obolibrary.org/obo/HP_0100952		
HP:0100953	biolink:PhenotypicFeature	Enlarged interhemispheric fissure		UMLS:C4020920	hp.json	Enlarged longitudinal cerebral fissure|Enlarged great longitudinal fissure|Enlarged longitudinal fissure	http://purl.obolibrary.org/obo/HP_0100953		
HP:0100950	biolink:PhenotypicFeature	Decreased 3-hydroxyacyl-CoA dehydrogenase level		SNOMEDCT_US:237999008|MSH:C566945|UMLS:C1969443	hp.json	Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase deficiency|Long chain 3 hydroxyacyl coA dehydrogenase deficiency|Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency	http://purl.obolibrary.org/obo/HP_0100950		
HP:0100951	biolink:PhenotypicFeature	Enlarged fossa interpeduncularis		UMLS:C4020922	hp.json	Enlarged interpeduncular cistern|Enlarged basal cistern	http://purl.obolibrary.org/obo/HP_0100951		
HP:0002366	biolink:PhenotypicFeature	Abnormal lower motor neuron morphology	Any structural anomaly of the lower motor neuron.	UMLS:C1865412	hp.json	Lower motor neuron disease|Lower motor neuron signs|Lower motor neuron manifestations	http://purl.obolibrary.org/obo/HP_0002366		
UBERON:0006652	biolink:AnatomicalEntity	muscular layer of vagina		FMA:19976|EMAPA:30997	hp.json	vaginal muscularis|tunica muscularis vaginae|muscular coat of vagina	http://purl.obolibrary.org/obo/UBERON_0006652		
HP:0002367	biolink:PhenotypicFeature	Visual hallucinations	Visual perceptions that are not elicited by a corresponding stimulus from the outside world.	UMLS:C0233763|MSH:D006212|SNOMEDCT_US:64269007	hp.json	Visual hallucinations	http://purl.obolibrary.org/obo/HP_0002367		
HP:0002365	biolink:PhenotypicFeature	Hypoplasia of the brainstem	Underdevelopment of the brainstem.	UMLS:C1842688	hp.json	Underdeveloped brainstem|Small brainstem|Brainstem hypoplasia|Hypoplastic brain stem|Hypoplastic brainstem	http://purl.obolibrary.org/obo/HP_0002365		
GO:0150147	biolink:BiologicalProcess	cell-cell junction disassembly	The disaggregation of a cell-cell junction into its constituent components.		hp.json		http://purl.obolibrary.org/obo/GO_0150147		
GO:0150146	biolink:BiologicalProcess	cell junction disassembly	The disaggregation of a cell junction into its constituent components.		hp.json		http://purl.obolibrary.org/obo/GO_0150146		
UBERON:0006658	biolink:AnatomicalEntity	interphalangeal joint	A joint that connects one phalanx to another along a proximodistal axis.	FMA:42765|EMAPA:37884|galen:InterphalangealJoint|NCIT:C101527	hp.json	inter-phalanx joint|inter-phalangeal joint	http://purl.obolibrary.org/obo/UBERON_0006658		pheno_slim
HP:0100958	biolink:PhenotypicFeature	Narrow foramen obturatorium	Decreased width of the foramen obturatorium. The foramen obturatorium (also known as the obturator foramen) is a hole located between the ischium and pubis bones of the pelvis.	UMLS:C4021910	hp.json		http://purl.obolibrary.org/obo/HP_0100958		
UBERON:0006657	biolink:AnatomicalEntity	glenoid fossa	Anatomical cavity for the proximal articular surface of the proximal limb or fin element with the scapulocoracoid or equivalent structure.	AAO:0000749|FMA:23275|EMAPA:25122|UMLS:C1261046|NCIT:C32682	hp.json	glenoid cavity|cavitus glenoidalis|cavitas glenoidalis|glenoid facet|cavitas glenoidalis scapulae|glenoid cavity|glenoid cavity of scapula	http://purl.obolibrary.org/obo/UBERON_0006657		pheno_slim
HP:0100959	biolink:PhenotypicFeature	Dense metaphyseal bands	Dense radiopaque bands of bone which are thicker than the adjacent diaphyseal cortex and may form at the metaphysis of growing bones. They appear on radiographs as bone that is more radiopaque that the adjacent diaphyseal cortex.	UMLS:C4020919	hp.json	Transverse metaphyseal bands|Dense metaphyseal lines	http://purl.obolibrary.org/obo/HP_0100959		
HP:0002362	biolink:PhenotypicFeature	Shuffling gait	A type of gait (walking) characterized by by dragging one's feet along or without lifting the feet fully from the ground.	SNOMEDCT_US:43005009|MSH:D020233|UMLS:C0231688	hp.json	Shuffled walk	http://purl.obolibrary.org/obo/HP_0002362		
UBERON:0006655	biolink:AnatomicalEntity	septum of scrotum	An incomplete wall of connective tissue and nonstriated muscle (dartos fascia) dividing the scrotum into two sacs, each containing a testis.	EMAPA:29745|FMA:20729	hp.json	septum scroti|scrotal septum	http://purl.obolibrary.org/obo/UBERON_0006655		
HP:0100957	biolink:PhenotypicFeature	Abnormal renal medulla morphology	Any structural abnormality of the medulla of the kidney.	UMLS:C4021911	hp.json	Abnormality of the renal medulla	http://purl.obolibrary.org/obo/HP_0100957		
HP:0002363	biolink:PhenotypicFeature	Abnormal brainstem morphology	An anomaly of the brainstem.	UMLS:C1850601	hp.json	Abnormal shape of brainstem|Abnormality of the brainstem|Abnormality of brainstem morphology	http://purl.obolibrary.org/obo/HP_0002363		
HP:0002360	biolink:PhenotypicFeature	Sleep disturbance	An abnormality of sleep including such phenomena as 1) insomnia/hypersomnia, 2) non-restorative sleep, 3) sleep schedule disorder, 4) excessive daytime somnolence, 5) sleep apnea, and 6) restlessness.	SNOMEDCT_US:53888004|UMLS:C0037317	hp.json	Trouble sleeping|Difficulty sleeping|Sleep disturbances|Sleep dysfunction	http://purl.obolibrary.org/obo/HP_0002360		
HP:0100954	biolink:PhenotypicFeature	Open operculum	Underdevelopment of the operculum.	UMLS:C2675973	hp.json		http://purl.obolibrary.org/obo/HP_0100954		
HP:0100955	biolink:PhenotypicFeature	Giant cell granuloma of mandible		UMLS:C4021912	hp.json		http://purl.obolibrary.org/obo/HP_0100955		
HP:0002361	biolink:PhenotypicFeature	Psychomotor deterioration	Loss of previously present mental and motor abilities.	UMLS:C1836842	hp.json	Psychomotor degeneration	http://purl.obolibrary.org/obo/HP_0002361		
UBERON:0006653	biolink:AnatomicalEntity	glans clitoris	Erectile tissue at the end of the clitoris, which is continuous with the intermediate part of the vestibulovaginal bulbs[BTO]. The clitoral glans (glans clitoridis) is an external portion of the clitoris[WP].	EMAPA:30829|EMAPA:19170|FMA:19999|UMLS:C0227769|NCIT:C32681|BTO:0003117	hp.json	clitoris glans|glans clitoris|glans clitoridis|glans of clitoris	http://purl.obolibrary.org/obo/UBERON_0006653		
HP:0100963	biolink:PhenotypicFeature	Hyperesthesia	Increased sensitivity to stimulation, excluding the special senses, which may refer to various modes of cutaneous sensibility including touch and thermal sensation without pain, as well as to pain.	UMLS:C0020453|MSH:D006941|SNOMEDCT_US:14151009	hp.json	Hyperaesthesia	http://purl.obolibrary.org/obo/HP_0100963		
HP:0100961	biolink:PhenotypicFeature	Enlarged hippocampus	Increase in size of the hippocampus.	UMLS:C4021908	hp.json		http://purl.obolibrary.org/obo/HP_0100961		
HP:0100962	biolink:PhenotypicFeature	Shyness		MSH:D012792|UMLS:C0037020	hp.json	Shyness	http://purl.obolibrary.org/obo/HP_0100962		
HP:0100960	biolink:PhenotypicFeature	Lateral ventricular asymmetry	Abnormal difference in size between the left and right lateral cerebral ventricles.	UMLS:C4021909	hp.json	Asymmetric ventricles|Asymmetric lateral ventricles|Cerebral lateral ventricular asymmetry	http://purl.obolibrary.org/obo/HP_0100960		
NCBITaxon:6236	biolink:OrganismalEntity	Rhabditida		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_6236		
NCBITaxon:6237	biolink:OrganismalEntity	Caenorhabditis		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_6237		
GO:0150111	biolink:BiologicalProcess	regulation of transepithelial transport	Any process that modulates the frequency, rate or extent of transepithelial transport.		hp.json		http://purl.obolibrary.org/obo/GO_0150111		
GO:0150110	biolink:BiologicalProcess	negative regulation of cholesterol esterification	Any process that stops, prevents or reduces the frequency, rate or extent of cholesterol esterification.		hp.json		http://purl.obolibrary.org/obo/GO_0150110		
UBERON:0004066	biolink:AnatomicalEntity	frontonasal prominence	The unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout.	VHOG:0001319|EMAPA:16681|FMA:293101|UMLS:C1517321|NCIT:C34182|EHDAA2:0000578|EHDAA:4778	hp.json	prominentia frontonasalis|forebrain prominence|embryonic frontonasal prominence|frontonasal process|frontonasal mass	http://purl.obolibrary.org/obo/UBERON_0004066		pheno_slim
GO:0150119	biolink:BiologicalProcess	negative regulation of protein localization to cell-cell junction	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell-cell junction.		hp.json	negative regulation of protein localisation to cell-cell junction	http://purl.obolibrary.org/obo/GO_0150119		
UBERON:0004067	biolink:AnatomicalEntity	lateral nasal prominence	The lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it.	EHDAA:4786|EMAPA:16805|FMA:295864|EHDAA2:0000916	hp.json	latero-nasal process|prominentia nasalis lateralis|lateral nasal swelling|lateral nasal process	http://purl.obolibrary.org/obo/UBERON_0004067		pheno_slim
UBERON:0004064	biolink:AnatomicalEntity	neural tube basal plate	The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons.	NCIT:C34111|AAO:0010561|Wikipedia:Basal_plate_(neural_tube)|EFO:0001904|UMLS:C1511061|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1372	hp.json	ventral part of neural tube|basal plate of neural tube|motor part of neural tube|basal plate of neural tube|basal plate|spinal cord basal plate	http://purl.obolibrary.org/obo/UBERON_0004064		pheno_slim|efo_slim
UBERON:0004062	biolink:AnatomicalEntity	neural tube marginal layer	The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter.	EMAPA:17151|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1368	hp.json	brain marginal zone|neural tube marginal zone	http://purl.obolibrary.org/obo/UBERON_0004062		pheno_slim
UBERON:0004060	biolink:AnatomicalEntity	neural tube ventricular layer	The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium.	EMAPA:17152|EMAPA_RETIRED:16783|MA:0003193|EMAPA:35362	hp.json	neural tube ependymal zone|neural tube ventricular germinal zone|ependymal layer|neural tube ependymal layer|neural tube ventricular zone	http://purl.obolibrary.org/obo/UBERON_0004060		pheno_slim
UBERON:0004061	biolink:AnatomicalEntity	neural tube mantle layer	The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer.	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1367|EMAPA:17148|EMAPA:35360	hp.json	neural tube intermediate zone|neural tube intermediate zone|future brain marginal layer	http://purl.obolibrary.org/obo/UBERON_0004061		pheno_slim
NCBITaxon:6243	biolink:OrganismalEntity	Rhabditidae		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_6243		
UBERON:0004068	biolink:AnatomicalEntity	medial nasal prominence	The central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it.	VHOG:0000804|EMAPA:16808|EHDAA2:0001076|EHDAA:4792|FMA:295858	hp.json	nasomedial prominence|medial-nasal process|prominentia nasalis medialis|medial nasal swelling|medial nasal process	http://purl.obolibrary.org/obo/UBERON_0004068		pheno_slim
UBERON:0018692	biolink:AnatomicalEntity	dorsal side of post-anal tail			hp.json		http://purl.obolibrary.org/obo/UBERON_0018692		
UBERON:0018691	biolink:AnatomicalEntity	ventral side of post-anal tail			hp.json		http://purl.obolibrary.org/obo/UBERON_0018691		
UBERON:0004053	biolink:AnatomicalEntity	external male genitalia	The external masculine genital organs, including the penis and scrotum.	EMAPA:30977|galen:MaleExternalGenitalia|FMA:45642|BTO:0003097	hp.json	external male genital organ|male external genitalia|organa genitalia masculina externa	http://purl.obolibrary.org/obo/UBERON_0004053		organ_slim|pheno_slim
UBERON:0004054	biolink:AnatomicalEntity	internal male genitalia	The internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands.	FMA:45655|BTO:0003096	hp.json	organa genitalia masculina interna|internal male genital organ|male internal genitalia	http://purl.obolibrary.org/obo/UBERON_0004054		organ_slim|pheno_slim
UBERON:0004058	biolink:AnatomicalEntity	biliary ductule	One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP].	ZFA:0005164|BTO:0002840|TAO:0005164|EMAPA:37440	hp.json	cholangiole|biliary ductule|bile capillary|ductuli biliferi|biliary ductule|bile ductule|terminal cholangiole	http://purl.obolibrary.org/obo/UBERON_0004058		pheno_slim
PR:P26952	biolink:Protein	interleukin-3 receptor subunit alpha (mouse)	An interleukin-3 receptor class 2 alpha chain that is encoded in the genome of mouse.	UniProtKB:P26952	hp.json	IL-3RA (mouse)|IL-3 receptor subunit alpha (mouse)|Sut-1|mIL3RA|CD123 (mouse)|interleukin-3 receptor class II alpha chain (mouse)|Il3ra|IL-3R subunit alpha (mouse)|IL-3R-alpha (mouse)	http://purl.obolibrary.org/obo/PR_P26952		
UBERON:0004042	biolink:AnatomicalEntity	spleen secondary B follicle	The nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp.	EMAPA:37961	hp.json	secondary spleen B cell follicle|splenic secondary B cell follicle	http://purl.obolibrary.org/obo/UBERON_0004042		pheno_slim|human_reference_atlas
HP:0002398	biolink:PhenotypicFeature	Degeneration of anterior horn cells		UMLS:C1843505	hp.json	Spinal cord anterior horn cell degeneration|Loss of spinal cord anterior horn cells|Degeneration of alpha-motor neurons in anterior horn cells of the spinal cord|Anterior horn cell loss|Degeneration of spinal cord anterior horn cells|Progressive loss of anterior horn cells	http://purl.obolibrary.org/obo/HP_0002398		
UBERON:0004040	biolink:AnatomicalEntity	cortical intermediate zone	The region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone.	EMAPA:32712|EMAPA:17545	hp.json	cortical mantle layer|cerebral cortex mantle zone|IZ|cerebral cortex mantle layer	http://purl.obolibrary.org/obo/UBERON_0004040		pheno_slim
UBERON:0004041	biolink:AnatomicalEntity	spleen primary B follicle	The nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp.	EMAPA:37960|FMA:15843	hp.json	primary spleen B cell follicle	http://purl.obolibrary.org/obo/UBERON_0004041		pheno_slim|human_reference_atlas
HP:0002392	biolink:PhenotypicFeature	EEG with polyspike wave complexes	The presence of complexes of repetitive spikes and waves in EEG.	UMLS:C4021757	hp.json	EEG: spike and multispike waves, 3-4 hz	http://purl.obolibrary.org/obo/HP_0002392		
HP:0002390	biolink:PhenotypicFeature	Spinal arteriovenous malformation		UMLS:C0348023|SNOMEDCT_US:261482004	hp.json		http://purl.obolibrary.org/obo/HP_0002390		
HP:0002395	biolink:PhenotypicFeature	Lower limb hyperreflexia		UMLS:C1836696	hp.json	Brisk lower extremity reflexes|Leg hyperreflexia|Overactive lower leg reflex|Increased deep tendon reflexes in the lower limbs|Hyperreflexia in the lower limbs|Hyperreflexia in lower limbs	http://purl.obolibrary.org/obo/HP_0002395		
HP:0002396	biolink:PhenotypicFeature	Cogwheel rigidity	A type of rigidity in which a muscle responds with cogwheellike jerks to the use of constant force in bending the limb (i.e., it gives way in little, repeated jerks when the muscle is passively stretched).	SNOMEDCT_US:55630000|UMLS:C0151564|MSH:D009127	hp.json		http://purl.obolibrary.org/obo/HP_0002396		
UBERON:0018674	biolink:AnatomicalEntity	heart vasculature	An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart.	ZFA:0005811|FMA:73747	hp.json	cardiac vasculature	http://purl.obolibrary.org/obo/UBERON_0018674		
UBERON:0018673	biolink:AnatomicalEntity	neck of fibula		FMA:35508|EMAPA:37891	hp.json	fibula neck|fibular neck	http://purl.obolibrary.org/obo/UBERON_0018673		
UBERON:0018679	biolink:AnatomicalEntity	thoracic splanchnic nerve	Thoracic splanchnic nerves are splanchnic nerves that arise from the sympathetic trunk in the thorax and travel inferiorly to provide sympathetic innervation to the abdomen. The nerves contain preganglionic sympathetic and general visceral afferent fibers.	FMA:6280	hp.json		http://purl.obolibrary.org/obo/UBERON_0018679		
GO:0150107	biolink:BiologicalProcess	positive regulation of protein localization to cell-cell junction	Any process that activates or increases the frequency, rate or extent of protein localization to cell-cell junction.		hp.json		http://purl.obolibrary.org/obo/GO_0150107		
UBERON:0006694	biolink:AnatomicalEntity	cerebellum vasculature	A vasculature that is part of a cerebellum.	FMA:268519	hp.json		http://purl.obolibrary.org/obo/UBERON_0006694		
GO:0150106	biolink:BiologicalProcess	regulation of protein localization to cell-cell junction	Any process that modulates the frequency, rate or extent of protein localization to cell-cell junction.		hp.json		http://purl.obolibrary.org/obo/GO_0150106		
GO:0044815	biolink:CellularComponent	DNA packaging complex	A protein complex that plays a role in the process of DNA packaging.		hp.json		http://purl.obolibrary.org/obo/GO_0044815		
UBERON:0006692	biolink:AnatomicalEntity	vertebral canal	A conduit enclosed within the vertebral foramen of the vertebrae through which the spinal cord passes.	GAID:242|UMLS:C1522467|NCIT:C34221|UMLS:C0037922|AAO:0000693|FMA:9680|NCIT:C33869	hp.json	vertebral canal|spinal cavity|neural canal|c. vertebralis|spinal canal|foramen vertebrale	http://purl.obolibrary.org/obo/UBERON_0006692		pheno_slim
GO:0150105	biolink:BiologicalProcess	protein localization to cell-cell junction	A process in which a protein is transported to, or maintained, in a location within a cell-cell junction.		hp.json		http://purl.obolibrary.org/obo/GO_0150105		
GO:0150102	biolink:BiologicalProcess	negative regulation of monocyte activation	Any process that stops, prevents or reduces the frequency, rate or extent of monocyte activation.		hp.json	repression of monocyte activation	http://purl.obolibrary.org/obo/GO_0150102		
NCBITaxon:6231	biolink:OrganismalEntity	Nematoda		GC_ID:1	hp.json	roundworms|roundworm|nematodes|Nemata|nematodes|nematode	http://purl.obolibrary.org/obo/NCBITaxon_6231		
UBERON:0004035	biolink:AnatomicalEntity	cortical subplate	The transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate.	DHBA:10522|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3233|EMAPA:32703|PBA:294021932|Wikipedia:Subplate|https://upload.wikimedia.org/wikipedia/commons/thumb/a/ac/Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png/360px-Corticogenesis_in_a_wild-type_mouse_with_captions_in_english_copy.png	hp.json	SP|cerebral cortex subplate|subplate zone|subplate	http://purl.obolibrary.org/obo/UBERON_0004035		pheno_slim
GO:0032838	biolink:CellularComponent	plasma membrane bounded cell projection cytoplasm	All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.		hp.json		http://purl.obolibrary.org/obo/GO_0032838		
HGNC:3012	biolink:Gene	DPYD (human)	A protein coding gene DPYD in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3012		
HP:0004959	biolink:PhenotypicFeature	Descending thoracic aorta aneurysm	An abnormal localized widening (dilatation) of the descending thoracic aorta.	Fyler:2754|UMLS:C4025266	hp.json	Dilatation of the descending thoracic aorta	http://purl.obolibrary.org/obo/HP_0004959		
GO:0032839	biolink:CellularComponent	dendrite cytoplasm	All of the contents of a dendrite, excluding the surrounding plasma membrane.		hp.json	dendritic cytoplasm	http://purl.obolibrary.org/obo/GO_0032839		
HP:0004952	biolink:PhenotypicFeature	Pulmonary arteriovenous fistulas	A rare vascular anomaly with a direct communication between pulmonary artery and pulmonary vein without an intervening capillary bed.	MSH:C562404|SNOMEDCT_US:111289009|UMLS:C0155675	hp.json		http://purl.obolibrary.org/obo/HP_0004952		
HP:0004950	biolink:PhenotypicFeature	Peripheral arterial stenosis	Narrowing of peripheral arteries with reduction of blood flow to the limbs. This feature may be quantified as an ankle-brachial index of less than 0.9, and may be manifested clinically as claudication.	MSH:D016491|SNOMEDCT_US:399957001|SNOMEDCT_US:400047006|UMLS:C0085096|MSH:D058729|UMLS:C1704436	hp.json	Peripheral artery disease|Peripheral artery occlusive disease|Occlusive arterial disease|Occlusive vascular disease|Peripheral vascular disease|Arterial disease of legs	http://purl.obolibrary.org/obo/HP_0004950		
HP:0004955	biolink:PhenotypicFeature	Generalized arterial tortuosity	Abnormal tortuous (i.e., twisted) form of arteries affecting most or all arteries.	UMLS:C3279191|UMLS:C1836651	hp.json	Generalised twisted arteries|Arterial tortuosity, generalized|Arterial tortuosity, general|Generalized twisted arteries|Generalised arterial tortuosity|Arterial tortuosity, generalised	http://purl.obolibrary.org/obo/HP_0004955		
HP:0004954	biolink:PhenotypicFeature	obsolete Dilatation of the descending aorta			hp.json		http://purl.obolibrary.org/obo/HP_0004954		
HP:0004953	biolink:PhenotypicFeature	obsolete Dilatation of abdominal aorta			hp.json		http://purl.obolibrary.org/obo/HP_0004953		
GO:0019852	biolink:BiologicalProcess	L-ascorbic acid metabolic process	The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.		hp.json	vitamin C metabolic process|ascorbate metabolic process|L-ascorbic acid metabolism|ascorbate metabolism|vitamin C metabolism	http://purl.obolibrary.org/obo/GO_0019852		
UBERON:0006603	biolink:AnatomicalEntity	presumptive mesoderm	Presumptive structure of the blastula that will develop into mesoderm.	ZFA:0001377|TAO:0001377|AAO:0000476|EFO:0003467	hp.json		http://purl.obolibrary.org/obo/UBERON_0006603		efo_slim
UBERON:0006601	biolink:AnatomicalEntity	presumptive ectoderm	Presumptive structure of the blastula that will develop into ectoderm.	ZFA:0001376|TAO:0001376|XAO:0004132|EFO:0003466|AAO:0000470	hp.json	presumptive epidermis	http://purl.obolibrary.org/obo/UBERON_0006601		efo_slim
UBERON:0006600	biolink:AnatomicalEntity	presumptive enteric nervous system		TAO:0001334|AAO:0000472|EFO:0003462|ZFA:0001334	hp.json	future enteric nervous system	http://purl.obolibrary.org/obo/UBERON_0006600		efo_slim
HP:0002308	biolink:PhenotypicFeature	Chiari malformation	Chiari malformation consists of a downward displacement of the cerebellar tonsils and the medulla through the foramen magnum, sometimes causing hydrocephalus as a result of obstruction of CSF outflow.	MSH:D001139|UMLS:C0003803|SNOMEDCT_US:253184003	hp.json	Arnold-Chiari malformation	http://purl.obolibrary.org/obo/HP_0002308		
HP:0004969	biolink:PhenotypicFeature	Peripheral pulmonary artery stenosis	Stenosis of a peripheral branch of the pulmonary artery.	UMLS:C0345030|SNOMEDCT_US:253631001	hp.json	Peripheral pulmonic stenosis|Narrowing of peripheral lung artery|peripheral pulmonary stenosis	http://purl.obolibrary.org/obo/HP_0004969		
HP:0002307	biolink:PhenotypicFeature	Drooling	Habitual flow of saliva out of the mouth.	UMLS:C0037036|UMLS:C0013132|MSH:D012798|SNOMEDCT_US:275295002|SNOMEDCT_US:53827007|SNOMEDCT_US:62718007	hp.json	Dribbling|Sialorrhea|Drooling	http://purl.obolibrary.org/obo/HP_0002307		
HP:0004968	biolink:PhenotypicFeature	Recurrent cerebral hemorrhage	Recurrent bleeding into the parenchyma of the brain.	UMLS:C4025264	hp.json	Recurrent hemorrhagic stroke|Recurrent cerebral haemorrhage	http://purl.obolibrary.org/obo/HP_0004968		
HP:0004963	biolink:PhenotypicFeature	Calcification of the aorta	Calcification, that is, pathological deposition of calcium salts in the aorta.	UMLS:C1096249	hp.json		http://purl.obolibrary.org/obo/HP_0004963		
HP:0002300	biolink:PhenotypicFeature	Mutism		MSH:D009155|SNOMEDCT_US:88052002|UMLS:C0026884	hp.json	Inability to speak|Muteness	http://purl.obolibrary.org/obo/HP_0002300		
HP:0002301	biolink:PhenotypicFeature	Hemiplegia	Paralysis (complete loss of muscle function) in the arm, leg, and in some cases the face on one side of the body.	UMLS:C0018991|MSH:D006429|SNOMEDCT_US:50582007	hp.json	Paralysis on one side of body	http://purl.obolibrary.org/obo/HP_0002301		
HP:0004962	biolink:PhenotypicFeature	Thoracic aorta calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the thoracic aorta.	UMLS:C1969292	hp.json		http://purl.obolibrary.org/obo/HP_0004962		
HP:0004961	biolink:PhenotypicFeature	Pulmonary artery sling	An anomalous origin of the left pulmonary artery, such that it arises from the posterior aspect of the right pulmonary artery and passes between the trachea and esophagus to reach the left hilum.	UMLS:C1856123	hp.json		http://purl.obolibrary.org/obo/HP_0004961		
HP:0004960	biolink:PhenotypicFeature	Absent pulmonary artery	A congenital defect with aplasia (absence) of one of the right or left pulmonary artery.	SNOMEDCT_US:86252004|UMLS:C0265905	hp.json	Absent lung artery|Missing pulmonary artery	http://purl.obolibrary.org/obo/HP_0004960		
HP:0002304	biolink:PhenotypicFeature	Akinesia	Inability to initiate changes in activity or movement and to perform ordinary volitional movements rapidly and easily.	SNOMEDCT_US:33994004|UMLS:C0085623	hp.json		http://purl.obolibrary.org/obo/HP_0002304		
GO:0019867	biolink:CellularComponent	outer membrane	The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.		hp.json		http://purl.obolibrary.org/obo/GO_0019867		goslim_metagenomics
HP:0004966	biolink:PhenotypicFeature	Medial calcification of large arteries	Calcification, that is, pathological deposition of calcium salts in the tunica media of large (conduit) arteries.	UMLS:C4025265	hp.json		http://purl.obolibrary.org/obo/HP_0004966		
HP:0002305	biolink:PhenotypicFeature	Athetosis	A slow, continuous, involuntary writhing movement that prevents maintenance of a stable posture. Athetosis involves continuous smooth movements that appear random and are not composed of recognizable sub-movements or movement fragments. In contrast to chorea, in athetosis, the same regions of the body are repeatedly involved. Athetosis may worsen with attempts at movement of posture, but athetosis can also occur at rest.	UMLS:C1845265|SNOMEDCT_US:58593005|SNOMEDCT_US:44913001|MSH:D001264|UMLS:C0004158	hp.json	Involuntary writhing movements in fingers, hands, toes, and feet|Athetoid movements|Involuntary writhing movements	http://purl.obolibrary.org/obo/HP_0002305		
GO:0019866	biolink:CellularComponent	organelle inner membrane	The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.		hp.json		http://purl.obolibrary.org/obo/GO_0019866		
HP:0004964	biolink:PhenotypicFeature	Pulmonary arterial medial hypertrophy	Increase in mass of the tunica media of the arteries in the pulmonary circulation.	UMLS:C1504382	hp.json	Hypertrophy of the pulmonary artery wall	http://purl.obolibrary.org/obo/HP_0004964		
HP:0004938	biolink:PhenotypicFeature	Tortuous cerebral arteries	Excessive bending, twisting, and winding of a cerebral artery.	UMLS:C1836791	hp.json	Twisted cerebral arteries	http://purl.obolibrary.org/obo/HP_0004938		
HP:0004937	biolink:PhenotypicFeature	Pulmonary artery aneurysm	An aneurysm (severe localized balloon-like outward bulging) in the pulmonary artery.	SNOMEDCT_US:194892009|UMLS:C0155676	hp.json		http://purl.obolibrary.org/obo/HP_0004937		
HP:0004936	biolink:PhenotypicFeature	Venous thrombosis	Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow.	SNOMEDCT_US:111293003|MSH:D020246|UMLS:C0042487	hp.json	Blood clot in vein	http://purl.obolibrary.org/obo/HP_0004936		
HP:0004935	biolink:PhenotypicFeature	Pulmonary artery atresia	A congenital anomaly with a narrowing or complete absence of the opening between the right ventricle and the pulmonary artery.	UMLS:C0265908|SNOMEDCT_US:204443008|SNOMEDCT_US:10930001	hp.json	Pulmonary atresia	http://purl.obolibrary.org/obo/HP_0004935		
HP:0004930	biolink:PhenotypicFeature	Abnormality of the pulmonary vasculature		UMLS:C4025271	hp.json	Abnormality of the lung blood vessels	http://purl.obolibrary.org/obo/HP_0004930		
HP:0004934	biolink:PhenotypicFeature	Vascular calcification	Abnormal calcification of the vasculature.	MSH:D061205|SNOMEDCT_US:237897009|UMLS:C0342649	hp.json		http://purl.obolibrary.org/obo/HP_0004934		
HP:0004933	biolink:PhenotypicFeature	Ascending aortic dissection	A separation of the layers within the wall of the ascending aorta. Tears in the intimal layer result in the propagation of dissection (proximally or distally) secondary to blood entering the intima-media space.	UMLS:C1836653	hp.json	Type A aortic dissection	http://purl.obolibrary.org/obo/HP_0004933		
HP:0004931	biolink:PhenotypicFeature	Arteriosclerosis of small cerebral arteries	Arteriosclerosis (increased thickness, increased stiffness, loss of elasticity) of the small arteries of the brain.	UMLS:C4025270|UMLS:C4280505	hp.json	Hardened artery wall in small cerebral arteries	http://purl.obolibrary.org/obo/HP_0004931		
HP:0004948	biolink:PhenotypicFeature	Vascular tortuosity	Abnormal twisting of arteries or veins.	UMLS:C2673776	hp.json	Twisted blood vessels	http://purl.obolibrary.org/obo/HP_0004948		
HP:0004947	biolink:PhenotypicFeature	Arteriovenous fistula	An abnormal connection between an artery and vein.	SNOMEDCT_US:439470001|SNOMEDCT_US:128617001|UMLS:C0003855|MSH:D001164	hp.json	Arteriovenous fistulas	http://purl.obolibrary.org/obo/HP_0004947		
HP:0004941	biolink:PhenotypicFeature	Extrahepatic portal hypertension	Increased pressure in the pre-hepatic portal vein.	UMLS:C4025268	hp.json		http://purl.obolibrary.org/obo/HP_0004941		
HP:0004940	biolink:PhenotypicFeature	Generalized arterial calcification	Calcification, that is, pathological deposition of calcium salts, affecting arteries distributed throughout the body.	UMLS:C4025269	hp.json	Generalised arterial calcification	http://purl.obolibrary.org/obo/HP_0004940		
HP:0004945	biolink:PhenotypicFeature	Extracranial internal carotid artery dissection	A separation (dissection) of the layers of the extracranial portion of the internal carotid artery wall.	UMLS:C4025267	hp.json		http://purl.obolibrary.org/obo/HP_0004945		
HP:0004944	biolink:PhenotypicFeature	Dilatation of the cerebral artery	The presence of a localized dilatation or ballooning of a cerebral artery.	UMLS:C0751003|SNOMEDCT_US:128608001|UMLS:C1290398|MSH:D002532	hp.json	Intracranial aneurysm|Brain aneurysm|Cerebral aneurysm|Cerebral artery aneurysm	http://purl.obolibrary.org/obo/HP_0004944		
HP:0004943	biolink:PhenotypicFeature	Accelerated atherosclerosis	Atherosclerosis which occurs in a person with certain risk factors (e.g., SLE, diabetes, smoking, hypertension, hypercholesterolaemia, family history of early heart disease) at an earlier age than would occur in another person without those risk factors.	UMLS:C4280504|UMLS:C1849618	hp.json	Accelerated plaque build-up in arteries	http://purl.obolibrary.org/obo/HP_0004943		
HP:0004942	biolink:PhenotypicFeature	Aortic aneurysm	Aortic dilatation refers to a dimension that is greater than the 95th percentile for the normal person age, sex and body size. In contrast, an aneurysm is defined as a localized dilation of the aorta that is more than 150 percent of predicted (ratio of observed to expected diameter 1.5 or more). Aneurysm should be distinguished from ectasia, which represents a diffuse dilation of the aorta less than 50 percent of normal aorta diameter.	UMLS:C0003486|Fyler:2301|Fyler:2708|SNOMEDCT_US:67362008|MSH:D001014	hp.json	Bulge in wall of large artery that carries blood away from heart|Aortic dilatation	http://purl.obolibrary.org/obo/HP_0004942		
HP:0002339	biolink:PhenotypicFeature	Abnormal caudate nucleus morphology	Any structural abnormality of the caudate nucleus.	UMLS:C4025711	hp.json	Abnormality of the caudate nucleus	http://purl.obolibrary.org/obo/HP_0002339		
UBERON:0018623	biolink:AnatomicalEntity	lower secondary incisor tooth		FMA:55713	hp.json	permanent lower incisor tooth|lower permanent incisor tooth|mandibular secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018623		
UBERON:0018621	biolink:AnatomicalEntity	upper canine tooth			hp.json	upper cuspid|maxillary canine tooth|upper canine	http://purl.obolibrary.org/obo/UBERON_0018621		
UBERON:0018622	biolink:AnatomicalEntity	lower canine tooth			hp.json	lower cuspid|lower canine|mandibular canine tooth	http://purl.obolibrary.org/obo/UBERON_0018622		
HP:0002333	biolink:PhenotypicFeature	Motor deterioration	Loss of previously present motor (i.e., movement) abilities.	UMLS:C1866284	hp.json	Progressive degeneration of movement	http://purl.obolibrary.org/obo/HP_0002333		
HP:0002334	biolink:PhenotypicFeature	Abnormal cerebellar vermis morphology	An anomaly of the vermis of cerebellum.	UMLS:C4025712	hp.json	Abnormality of the cerebellar vermis	http://purl.obolibrary.org/obo/HP_0002334		
HP:0002331	biolink:PhenotypicFeature	Recurrent paroxysmal headache	Repeated episodes of headache with rapid onset, reaching a peak within minutes and of short duration (less than one hour) with pain that is throbbing, pulsating, or bursting in quality.	UMLS:C1854337	hp.json		http://purl.obolibrary.org/obo/HP_0002331		
GO:0019814	biolink:CellularComponent	immunoglobulin complex	A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json	antibody	http://purl.obolibrary.org/obo/GO_0019814		goslim_pir
HP:0004993	biolink:PhenotypicFeature	Slender long bones with narrow diaphyses	Reduced diameter of a long bone with a more pronounced reduction of the diameter of the diaphysis of the long bones.	UMLS:C2675547	hp.json	Slender long bones with narrow shaft	http://purl.obolibrary.org/obo/HP_0004993		
HP:0002332	biolink:PhenotypicFeature	Lack of peer relationships		UMLS:C1845337	hp.json	Lack of peer relationships	http://purl.obolibrary.org/obo/HP_0002332		
HP:0002335	biolink:PhenotypicFeature	Agenesis of cerebellar vermis	Congenital absence of the vermis of cerebellum.	MSH:C536293|SNOMEDCT_US:253175003|UMLS:C0431399|SNOMEDCT_US:716997004	hp.json	Cerebellar vermis aplasia|Vermian agenesis	http://purl.obolibrary.org/obo/HP_0002335		
HP:0004997	biolink:PhenotypicFeature	Multicentric ossification of proximal humeral epiphyses		UMLS:C1857192	hp.json		http://purl.obolibrary.org/obo/HP_0004997		
UBERON:0006648	biolink:AnatomicalEntity	adventitia of seminal vesicle	An adventitia that is part of a seminal vesicle.	FMA:19403|EMAPA:29775	hp.json	tunica adventitia glandulae vesiculosae|tunica adventitia (vesicula seminalis)|seminal vesicle adventitia|adventitia of seminal gland	http://purl.obolibrary.org/obo/UBERON_0006648		
UBERON:0006647	biolink:AnatomicalEntity	adventitia of ductus deferens	An adventitia that is part of a vas deferens.	EMAPA:29767|FMA:19238	hp.json	deferent ductal adventitia|adventitia of deferent duct|adventitia of ductus deferens|adventitia of vas deferens|tunica adventitia ductus deferentis|tunica adventitia (ductus deferens)	http://purl.obolibrary.org/obo/UBERON_0006647		
UBERON:0006646	biolink:AnatomicalEntity	muscle layer of epididymis	A muscle layer that is part of a epididymis.	FMA:19149|EMAPA:30747	hp.json		http://purl.obolibrary.org/obo/UBERON_0006646		
UBERON:0006645	biolink:AnatomicalEntity	adventitia of epididymis	An adventitia that is part of a epididymis.	EMAPA:30443|FMA:19136	hp.json	epididymis adventitia	http://purl.obolibrary.org/obo/UBERON_0006645		
HP:0002330	biolink:PhenotypicFeature	Paroxysmal drowsiness	Attacks of disabling daytime drowsiness and low alertness.	UMLS:C4025713	hp.json		http://purl.obolibrary.org/obo/HP_0002330		
HP:0004991	biolink:PhenotypicFeature	Rhizomelic arm shortening	Disproportionate shortening of the proximal segment of the arm (i.e. the humerus).	UMLS:C1969532	hp.json		http://purl.obolibrary.org/obo/HP_0004991		
HP:0004990	biolink:PhenotypicFeature	Epiphyseal streaking		UMLS:C1858039	hp.json		http://purl.obolibrary.org/obo/HP_0004990		
UBERON:0006642	biolink:AnatomicalEntity	muscle layer of oviduct	A muscle layer that is part of a fallopian tube.	SCTID:259488000|FMA:18318|EMAPA:29046	hp.json	muscle layer of oviduct|muscular coat of uterine tube|tunica muscularis tubae uterinae|muscle layer of fallopian tube|muscularis of uterine tube|tunica muscularis (Tuba uterina)|muscle layer of uterine tube|uterine tubal muscularis|muscular layer of uterine tube	http://purl.obolibrary.org/obo/UBERON_0006642		human_reference_atlas
UBERON:0018616	biolink:AnatomicalEntity	primary upper tooth			hp.json	deciduous upper tooth	http://purl.obolibrary.org/obo/UBERON_0018616		
UBERON:0018617	biolink:AnatomicalEntity	primary lower tooth			hp.json	deciduous lower tooth	http://purl.obolibrary.org/obo/UBERON_0018617		
UBERON:0018614	biolink:AnatomicalEntity	permanent lower tooth			hp.json	secondary lower tooth	http://purl.obolibrary.org/obo/UBERON_0018614		
CHEBI:43474	biolink:ChemicalSubstance	hydrogenphosphate	A phosphate ion that is the conjugate base of dihydrogenphosphate.	PDBeChem:PO4|PDBeChem:PI|Gmelin:1998|MolBase:1628	hp.json	hydrogentetraoxophosphate(2-)|hydrogenphosphate|hydrogen phosphate|phosphate|[P(OH)O3](2-)|HYDROGENPHOSPHATE ION|hydroxidotrioxidophosphate(2-)|INORGANIC PHOSPHATE GROUP|HPO4(2-)|[PO3(OH)](2-)|hydrogen(tetraoxidophosphate)(2-)|hydrogentetraoxophosphate(V)	http://purl.obolibrary.org/obo/CHEBI_43474		3_STAR
UBERON:0018613	biolink:AnatomicalEntity	secondary upper tooth			hp.json	permanent upper tooth	http://purl.obolibrary.org/obo/UBERON_0018613		
HP:0002344	biolink:PhenotypicFeature	Progressive neurologic deterioration		UMLS:C1854838	hp.json	Progressive neurodegeneration|Neurologic deterioration|Neurologic deterioration, progressive|Progressive mental deterioration|Worsening neurological symptoms	http://purl.obolibrary.org/obo/HP_0002344		
HP:0002345	biolink:PhenotypicFeature	Action tremor	A tremor present when the limbs are active, either when outstretched in a certain position or throughout a voluntary movement.	MSH:D014202|UMLS:C0234376|UMLS:C4020853|SNOMEDCT_US:30721006	hp.json	Ataxic tremor	http://purl.obolibrary.org/obo/HP_0002345		
HP:0002342	biolink:PhenotypicFeature	Intellectual disability, moderate	Moderate mental retardation is defined as an intelligence quotient (IQ) in the range of 35-49.	SNOMEDCT_US:61152003|UMLS:C0026351	hp.json	Moderate mental retardation|IQ between 34 and 49|Mental retardation, moderate|Moderate mental deficiency	http://purl.obolibrary.org/obo/HP_0002342		
GO:0019825	biolink:MolecularActivity	oxygen binding	Binding to oxygen (O2).		hp.json	cytochrome P450|cytochrome P450 activity	http://purl.obolibrary.org/obo/GO_0019825		goslim_plant|goslim_pir
HP:0002343	biolink:PhenotypicFeature	Normal pressure hydrocephalus	A form of hydrocephalus characterized by enlarged cerebral ventricles and normal cerebrospinal fluid (CSF) pressure upon lumbar puncture.	MSH:D006850|SNOMEDCT_US:30753002|UMLS:C0020258	hp.json	Normal-pressure hydrocephalus	http://purl.obolibrary.org/obo/HP_0002343		
HP:0002349	biolink:PhenotypicFeature	Focal aware seizure	A type of focal-onset seizure in which awareness is preserved. Awareness during a seizure is defined as the patient being fully aware of themself and their environment throughout the seizure, even if immobile.	UMLS:C0234974|SNOMEDCT_US:117891000119100|MSH:D004828|SNOMEDCT_US:79348005	hp.json	Focal seizure without impairment of awareness|Simple partial seizures|Focal aware seizures|Focal seizure without impairment of consciousness or awareness|Partial seizure without impairment of awareness|Focal seizure with retained awareness|Partial seizure with retained awareness|Simple partial seizure|Focal seizures without impairment of consciousness or awareness	http://purl.obolibrary.org/obo/HP_0002349		
HP:0002346	biolink:PhenotypicFeature	Head tremor	An unintentional, oscillating to-and-fro muscle movement affecting head movement.	UMLS:C0239882	hp.json	Head tremor	http://purl.obolibrary.org/obo/HP_0002346		
UBERON:0018607	biolink:AnatomicalEntity	permanent molar tooth 2			hp.json	second permanent molar|permanent second molar tooth|second permanent molar tooth|secondary second molar tooth	http://purl.obolibrary.org/obo/UBERON_0018607		pheno_slim
UBERON:0018608	biolink:AnatomicalEntity	permanent molar tooth 1			hp.json	first permanent molar|permanent first molar tooth|first permanent molar tooth	http://purl.obolibrary.org/obo/UBERON_0018608		pheno_slim
UBERON:0006635	biolink:AnatomicalEntity	anterior abdominal wall	The abdominal wall represents the boundaries of the abdominal cavity. The abdominal wall is split into the posterior (back), lateral (sides) and anterior (front) walls. There is a common set of layers covering and forming all the walls: the deepest being the extraperitoneal fat, the parietal peritoneum, and a layer of fascia which has different names over where it covers (eg transversalis, psoas fascia). Superficial to these, but not present in the posterior wall are the three layers of muscle, the transversus abdominis (transverse abdominal muscle), the internal (obliquus internus) and the external oblique (obliquus externus).	FMA:14627|VHOG:0000764|EMAPA:17744|EHDAA:5976	hp.json	ventral abdominal wall	http://purl.obolibrary.org/obo/UBERON_0006635		
HP:0002340	biolink:PhenotypicFeature	Caudate atrophy		UMLS:C1858116	hp.json	Caudate degeneration	http://purl.obolibrary.org/obo/HP_0002340		
UBERON:0006633	biolink:AnatomicalEntity	coracoid process of scapula	A process of the scapula in most mammals representing the remnant of the coracoid bone of lower vertebrates thas has become fused with the scapula.	FMA:13455|EMAPA:25121	hp.json	coracoid process|processus coracoideus|coracoid process of the scapula	http://purl.obolibrary.org/obo/UBERON_0006633		
HP:0002341	biolink:PhenotypicFeature	Cervical cord compression	Compression of the spinal cord in the cervical region, generally manifested by paresthesias and numbness, weakness, difficulty walking, abnormalities of coordination, and neck pain or stiffness.	UMLS:C0852866	hp.json	Cervical cord compression myelopathy	http://purl.obolibrary.org/obo/HP_0002341		
UBERON:0006632	biolink:AnatomicalEntity	musculo-phrenic artery	An artery with its origin in the lateral terminal branch of the internal thoracic artery, with distribution to the diaphragm and the intercostal muscles, and with anastomoses to the branches of the pericardiacophrenic and inferior phrenic.	FMA:10645|EMAPA:19215	hp.json	musculophrenic artery	http://purl.obolibrary.org/obo/UBERON_0006632		human_reference_atlas
UBERON:0006617	biolink:AnatomicalEntity	left external ear	An external ear that is in the left side of a multicellular organism.	FMA:53644|EMAPA:37360	hp.json	left auricular region	http://purl.obolibrary.org/obo/UBERON_0006617		pheno_slim
UBERON:0018606	biolink:AnatomicalEntity	molar tooth 2	The molar tooth of the upper or lower jaw that is phylogenetically number 2.	FMA:321613	hp.json	molar 2|second molar tooth|molar 2 tooth	http://purl.obolibrary.org/obo/UBERON_0018606		
HP:0002317	biolink:PhenotypicFeature	Unsteady gait		SNOMEDCT_US:394616008|MSH:D020233|UMLS:C0231686|SNOMEDCT_US:22631008	hp.json	Gait instability|Unsteady walk	http://purl.obolibrary.org/obo/HP_0002317		
UBERON:0018603	biolink:AnatomicalEntity	upper central incisor tooth	An incisor tooth that is in_the_central_side_of a dentition and is part of a upper jaw region.	FMA:290180	hp.json	maxillary central incisor|upper central incisor	http://purl.obolibrary.org/obo/UBERON_0018603		pheno_slim
HP:0004979	biolink:PhenotypicFeature	Metaphyseal sclerosis	Abnormally increased density of metaphyseal bone.	UMLS:C3552526	hp.json	Sclerotic metaphyses|Increased bone density in wide portion of long bone	http://purl.obolibrary.org/obo/HP_0004979		
UBERON:0018604	biolink:AnatomicalEntity	upper lateral incisor tooth	An incisor tooth that is in_the_lateral_side_of a dentition and is part of a upper jaw region.	FMA:290194	hp.json	maxillary lateral incisor|upper lateral incisor	http://purl.obolibrary.org/obo/UBERON_0018604		pheno_slim
HP:0002318	biolink:PhenotypicFeature	Cervical myelopathy		SNOMEDCT_US:202664003|UMLS:C0149645	hp.json		http://purl.obolibrary.org/obo/HP_0002318		
UBERON:0018601	biolink:AnatomicalEntity	lower central incisor tooth	An incisor tooth that is in_the_central_side_of a dentition and is part of a lower jaw region.	FMA:290182	hp.json	mandibular central incisor|lower central incisor	http://purl.obolibrary.org/obo/UBERON_0018601		pheno_slim
UBERON:0018602	biolink:AnatomicalEntity	lower lateral incisor tooth	An incisor tooth that is in_the_lateral_side_of a dentition and is part of a lower jaw region.	FMA:290197	hp.json	mandibular lateral incisor|lower lateral incisor	http://purl.obolibrary.org/obo/UBERON_0018602		pheno_slim
UBERON:0018600	biolink:AnatomicalEntity	lower second primary molar tooth		FMA:84237	hp.json	lower primary tooth E|lower second deciduous molar tooth	http://purl.obolibrary.org/obo/UBERON_0018600		
HP:0002311	biolink:PhenotypicFeature	Incoordination		MSH:D001259|SNOMEDCT_US:302289002|UMLS:C0520966|SNOMEDCT_US:281016006	hp.json	Limb incoordination|Incoordination|Difficulties in coordination|Incoordination of limb movements	http://purl.obolibrary.org/obo/HP_0002311		
HP:0004974	biolink:PhenotypicFeature	Coarctation of abdominal aorta	Coarctation of the aorta is a narrowing or constriction of a segment of the abdominal aorta.	UMLS:C4025263	hp.json		http://purl.obolibrary.org/obo/HP_0004974		
HP:0002312	biolink:PhenotypicFeature	Clumsiness	Lack of physical coordination resulting in an abnormal tendency to drop items or bump into objects.	UMLS:C0233844|SNOMEDCT_US:7006003	hp.json	Clumsiness	http://purl.obolibrary.org/obo/HP_0002312		
HP:0004972	biolink:PhenotypicFeature	Elevated mean arterial pressure	An abnormal increase in the average blood pressure in an individual during a single cardiac cycle.	UMLS:C1840376	hp.json		http://purl.obolibrary.org/obo/HP_0004972		
HP:0004971	biolink:PhenotypicFeature	Pulmonary artery hypoplasia	Underdevelopment of the pulmonary artery.	UMLS:C0265910|SNOMEDCT_US:54682008|Fyler:2966	hp.json	Underdeveloped pulmonary artery|Underdeveloped lung artery	http://purl.obolibrary.org/obo/HP_0004971		
HP:0002310	biolink:PhenotypicFeature	Orofacial dyskinesia		SNOMEDCT_US:49386006|UMLS:C0152115|MSH:D020820	hp.json	Orofacial dyskinesias	http://purl.obolibrary.org/obo/HP_0002310		
HP:0002315	biolink:PhenotypicFeature	Headache	Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.	MSH:D006261|UMLS:C0018681|SNOMEDCT_US:25064002	hp.json	Headache|Headaches	http://purl.obolibrary.org/obo/HP_0002315		
HP:0100909	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the 3rd finger		UMLS:C4021933	hp.json	Increased bone density in innermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0100909		
HP:0004977	biolink:PhenotypicFeature	Bilateral radial aplasia	Missing radius bone on both sides associated with congenital failure of development.	UMLS:C1848840	hp.json	Bilateral absence of radius	http://purl.obolibrary.org/obo/HP_0004977		
HP:0100907	biolink:PhenotypicFeature	Sclerosis of the middle phalanx of the 5th finger		UMLS:C4021935	hp.json	Increased bone density in the middle bone of the pinkie finger|Increased bone density in the middle bone of the little finger|Increased bone density in the middle bone of the pinky finger	http://purl.obolibrary.org/obo/HP_0100907		
HP:0004976	biolink:PhenotypicFeature	Knee dislocation		MSH:D031221|SNOMEDCT_US:58320001|UMLS:C0159970	hp.json	Knee dislocations|Dislocations of the knees	http://purl.obolibrary.org/obo/HP_0004976		
HP:0002313	biolink:PhenotypicFeature	Spastic paraparesis		SNOMEDCT_US:312444006|UMLS:C0037771|MSH:D020336	hp.json		http://purl.obolibrary.org/obo/HP_0002313		
HP:0002314	biolink:PhenotypicFeature	Degeneration of the lateral corticospinal tracts	Deterioration of the tissues of the lateral corticospinal tracts.	UMLS:C1846566	hp.json	Degeneration of lateral corticospinal tracts	http://purl.obolibrary.org/obo/HP_0002314		
HP:0004975	biolink:PhenotypicFeature	Erlenmeyer flask deformity of the femurs	Flaring of distal femur.	UMLS:C1855895	hp.json	Erlenmeyer flask shaped thighbone|Erlenmeyer flask femora|Erlenmeyer flask deformity of distal femur	http://purl.obolibrary.org/obo/HP_0004975		
HP:0100908	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the 2nd finger		UMLS:C4021934	hp.json	Increased bone density in the innermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0100908		
HP:0100905	biolink:PhenotypicFeature	Sclerosis of the middle phalanx of the 3rd finger		UMLS:C4021937	hp.json	Increased bone density in the middle bone of the middle finger	http://purl.obolibrary.org/obo/HP_0100905		
HP:0100906	biolink:PhenotypicFeature	Sclerosis of the middle phalanx of the 4th finger		UMLS:C4021936	hp.json	Increased bone density in the middle bone of the ring finger	http://purl.obolibrary.org/obo/HP_0100906		
HP:0100903	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the 5th finger		UMLS:C4021939	hp.json	Increased bone density in the outermost pinky finger bone|Increased bone density in the outermost little finger bone|Increased bone density in the outermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0100903		
HP:0100904	biolink:PhenotypicFeature	Sclerosis of the middle phalanx of the 2nd finger		UMLS:C4021938	hp.json	Increased bone density in the middle bone of the index finger	http://purl.obolibrary.org/obo/HP_0100904		
HP:0004970	biolink:PhenotypicFeature	Ascending tubular aorta aneurysm	An abnormal localized widening (dilatation) of the tubular part of the ascending aorta.	Fyler:2701|SNOMEDCT_US:253645007|UMLS:C0345049|Fyler:2310	hp.json	Bulging of wall of large artery located above heart|Aneurysm of the ascending tubular aorta|Ascending aortic dilation|Ascending aortic aneurysm|Ascending aorta dilation|Dilatation of ascending aorta	http://purl.obolibrary.org/obo/HP_0004970		
HP:0100901	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the 3rd finger		UMLS:C4021941	hp.json	Increased bone density in the outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0100901		
HP:0100902	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the 4th finger		UMLS:C4021940	hp.json	Increased bone density in the outermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0100902		
HP:0100900	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the 2nd finger		UMLS:C4021942	hp.json	Increased bone density in the outermost bone of the index finger	http://purl.obolibrary.org/obo/HP_0100900		
UBERON:0006609	biolink:AnatomicalEntity	corpus cavernosum		FMA:321004|BTO:0005454	hp.json		http://purl.obolibrary.org/obo/UBERON_0006609		pheno_slim
UBERON:0006608	biolink:AnatomicalEntity	corpus cavernosum clitoridis	The corpus cavernosum clitoridis is one of a pair of sponge-like regions of erectile tissue which contain most of the blood in the clitoris during clitoral erection. This is homologous to the corpus cavernosum penis in the male; the body of the clitoris contains erectile tissue in a pair of corpora cavernosa (literally 'cave-like bodies'), with a recognisably similar structure.	FMA:20172|BTO:0002018	hp.json	corpus cavernosum|corpus cavernosum clitoridis|cavernous body of clitoris|corpus cavernosum of clitoris|clitoral corpus cavernosum	http://purl.obolibrary.org/obo/UBERON_0006608		
UBERON:0006606	biolink:AnatomicalEntity	mandibular symphysis	A cartilaginous joint that connects left and right mandibles/dentary bones. Mandibular symphysis is unpaired[TAO,modified].	Wikipedia:Symphysis_menti|FMA:75779|TAO:0001851|ZFA:0005488|AAO:0000277|MA:0001490	hp.json	inter-dentary joint|symphysis mandibulae|symphysis mandibulae|mental symphysis|inter-mandibular joint|symphysis menti|dentary symphysis|mental symphysis	http://purl.obolibrary.org/obo/UBERON_0006606		vertebrate_core|pheno_slim
HP:0002329	biolink:PhenotypicFeature	Drowsiness	Excessive daytime sleepiness.	SNOMEDCT_US:79519003|MSH:D012894|UMLS:C0013144|SNOMEDCT_US:271782001	hp.json	Sleepy|Drowsiness	http://purl.obolibrary.org/obo/HP_0002329		
HP:0002322	biolink:PhenotypicFeature	Resting tremor	A resting tremor occurs when muscles are at rest and becomes less noticeable or disappears when the affected muscles are moved. Resting tremors are often slow and coarse.	MSH:D014202|UMLS:C0234379|SNOMEDCT_US:25082004	hp.json	Resting tremor|Parkinsonian tremor|Tremor at rest|Rest tremor	http://purl.obolibrary.org/obo/HP_0002322		
HP:0002323	biolink:PhenotypicFeature	Anencephaly	Anencephaly is a developmental anomaly characterized by a fetus that has no calvarium, with a lack of most or all of the fetus' brain tissue. Anencephaly belongs to a collective group known as neural tube defects (NTD) and is a result of the neural tube failing to close in its rostral end during fetal development.	Fyler:4332|SNOMEDCT_US:89369001|UMLS:C0002902|MSH:D000757	hp.json	Foetal anencephaly|Fetal anencephaly|Embryonic anencephaly	http://purl.obolibrary.org/obo/HP_0002323		
HP:0002321	biolink:PhenotypicFeature	Vertigo	An abnormal sensation of spinning while the body is actually stationary.	SNOMEDCT_US:399153001|UMLS:C0012833|MSH:D004244|UMLS:C0042571|SNOMEDCT_US:399090003|MSH:D014717|SNOMEDCT_US:404640003|SNOMEDCT_US:271789005	hp.json	Dizzy spell|Dizziness	http://purl.obolibrary.org/obo/HP_0002321		
HP:0002326	biolink:PhenotypicFeature	Transient ischemic attack		MSH:D002546|UMLS:C0917805	hp.json	Transient ischemic attacks|TIA|Mini stroke|Transient ischaemic attack|Transient ischaemic attacks	http://purl.obolibrary.org/obo/HP_0002326		
HP:0004987	biolink:PhenotypicFeature	Mesomelic leg shortening	Shortening of the middle parts of the leg in relation to the upper and terminal segments.	UMLS:C1969178	hp.json	Mesomelia of the lower limbs|Mesomelic lower limb shortening	http://purl.obolibrary.org/obo/HP_0004987		
HP:0100918	biolink:PhenotypicFeature	Sclerosis of 2nd finger phalanx	An elevation in bone density in one or more phalanges of the second finger. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020937	hp.json	Increased bone density in 2nd finger bone|Sclerosis of the phalanges of the 2nd finger	http://purl.obolibrary.org/obo/HP_0100918		
HP:0002324	biolink:PhenotypicFeature	Hydranencephaly	A defect of development of the brain characterized by replacement of greater portions of the cerebral hemispheres and the corpus striatum by cerebrospinal fluid (CSF) and glial tissue.	UMLS:C0020225|MSH:D006832|SNOMEDCT_US:30023002	hp.json	Hydrancephaly	http://purl.obolibrary.org/obo/HP_0002324		
HP:0100919	biolink:PhenotypicFeature	Sclerosis of 3rd finger phalanx	An elevation in bone density in one or more phalanges of the third finger. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020936	hp.json	Sclerosis of the phalanges of the 3rd finger|Increased bone density in middle finger bone	http://purl.obolibrary.org/obo/HP_0100919		
HP:0004986	biolink:PhenotypicFeature	obsolete Rudimentary to absent fibulae			hp.json		http://purl.obolibrary.org/obo/HP_0004986		
HP:0100916	biolink:PhenotypicFeature	Sclerosis of middle finger phalanx	An elevation in bone density in one or more middle phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020939	hp.json	Increased bone density in middle finger bone of hand|Sclerosis of the middle phalanges of the hand	http://purl.obolibrary.org/obo/HP_0100916		
UBERON:0006616	biolink:AnatomicalEntity	right external ear	An external ear that is in the right side of a multicellular organism.	FMA:53643|EMAPA:37361	hp.json	right auricular region	http://purl.obolibrary.org/obo/UBERON_0006616		pheno_slim
UBERON:0006615	biolink:AnatomicalEntity	venous sinus	A large vein or channel for the circulation of venous blood.	NCIT:C12877|UMLS:C0226504|MA:0000070|ZFA:0007072	hp.json	blood sinus	http://purl.obolibrary.org/obo/UBERON_0006615		pheno_slim
HP:0100917	biolink:PhenotypicFeature	Sclerosis of proximal finger phalanx	An elevation in bone density in one or more proximal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020938	hp.json	Increased bone density in innermost finger bone|Sclerosis of the proximal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0100917		
UBERON:0006614	biolink:AnatomicalEntity	aponeurosis	A sheet of extracellular matrix.	EHDAA2:0003092|MESH:D000070606|UMLS:C0225205|AEO:0000092|NCIT:C32133|ZFA:0005652|FMA:9722	hp.json	aponeurotic|aponeuroses	http://purl.obolibrary.org/obo/UBERON_0006614		
HP:0100914	biolink:PhenotypicFeature	Sclerosis of the 1st metacarpal		UMLS:C4021928	hp.json	Increased bone density in 1st long bone of hand	http://purl.obolibrary.org/obo/HP_0100914		
HP:0100915	biolink:PhenotypicFeature	Sclerosis of distal finger phalanx	An elevation in bone density in one or more distal phalanges of the fingers. Sclerosis is normally detected on a radiograph as an area of increased opacity.	UMLS:C4020940	hp.json	Increased bone density in outermost finger bone|Sclerosis of the distal phalanges of the hand	http://purl.obolibrary.org/obo/HP_0100915		
HP:0100912	biolink:PhenotypicFeature	Sclerosis of the distal phalanx of the thumb	An elevation of bone density in the distal phalanx of the thumb.	UMLS:C4021930	hp.json	Increased bone density in the outermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0100912		
HP:0004981	biolink:PhenotypicFeature	Prominent styloid process of ulna		UMLS:C4025262	hp.json		http://purl.obolibrary.org/obo/HP_0004981		
HP:0004980	biolink:PhenotypicFeature	Metaphyseal rarefaction	Reduction in density of metaphyseal bony tissue.	UMLS:C1832146	hp.json	Rarefaction of the metaphyses	http://purl.obolibrary.org/obo/HP_0004980		
HP:0100913	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the thumb	An elevation of bone density in the proximal phalanx of the thumb.	UMLS:C4021929	hp.json	Increased bone density in the innermost bone of the thumb	http://purl.obolibrary.org/obo/HP_0100913		
HP:0100910	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the 4th finger		UMLS:C4021932	hp.json	Increased bone density in the innermost bone of the ring finger	http://purl.obolibrary.org/obo/HP_0100910		
HP:0100911	biolink:PhenotypicFeature	Sclerosis of the proximal phalanx of the 5th finger		UMLS:C4021931	hp.json	Increased bone density in innermost little finger bone|Increased bone density in innermost pinkie finger bone|Increased bone density in innermost pinky finger bone	http://purl.obolibrary.org/obo/HP_0100911		
GO:0042360	biolink:BiologicalProcess	vitamin E metabolic process	The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.		hp.json	alpha-tocopherol metabolism|vitamin E metabolism|tocopherol metabolism|alpha-tocopherol metabolic process|tocopherol metabolic process	http://purl.obolibrary.org/obo/GO_0042360		
CHEBI:5686	biolink:ChemicalSubstance	heterocyclic compound	A cyclic compound having as ring members atoms of at least two different elements.		hp.json	heterocyclic compounds|compuesto heterociclico|heterocycle|compuestos heterociclicos|Heterocyclic compound	http://purl.obolibrary.org/obo/CHEBI_5686		3_STAR
GO:0042373	biolink:BiologicalProcess	vitamin K metabolic process	The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.		hp.json	naphthoquinone metabolic process|naphthoquinone metabolism|vitamin K metabolism	http://purl.obolibrary.org/obo/GO_0042373		
RO:0002380	biolink:NamedThing	branching part of	x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y	RO:0002380	hp.json		http://purl.obolibrary.org/obo/RO_0002380		ro-eco
GO:0042391	biolink:BiologicalProcess	regulation of membrane potential	Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0042391		
RO:0002385	biolink:NamedThing	has potential to developmentally contribute to	x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y	RO:0002385	hp.json		http://purl.obolibrary.org/obo/RO_0002385		
RO:0002386	biolink:NamedThing	has potential to developmentally induce	x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y		hp.json		http://purl.obolibrary.org/obo/RO_0002386		
RO:0002387	biolink:NamedThing	has potential to develop into	x has the potential to develop into y iff x develops into y or if x is capable of developing into y	RO:0002387	hp.json		http://purl.obolibrary.org/obo/RO_0002387		
RO:0002388	biolink:NamedThing	has potential to directly develop into	x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y		hp.json		http://purl.obolibrary.org/obo/RO_0002388		
RO:0002384	biolink:NamedThing	has developmental potential involving	x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).		hp.json		http://purl.obolibrary.org/obo/RO_0002384		
PR:000004089	biolink:Protein	aldehyde oxidase	A protein that is a translation product of the human AOX1 gene or a 1:1 ortholog thereof.		hp.json	AOX1|AO|Ro|retinal oxidase	http://purl.obolibrary.org/obo/PR_000004089		
RO:0002379	biolink:NamedThing	spatially coextensive with	x spatially_coextensive_with y if and inly if x and y have the same location		hp.json		http://purl.obolibrary.org/obo/RO_0002379		
GO:0030336	biolink:BiologicalProcess	negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.		hp.json	downregulation of cell migration|down regulation of cell migration|inhibition of cell migration|down-regulation of cell migration	http://purl.obolibrary.org/obo/GO_0030336		
GO:0032997	biolink:CellularComponent	Fc receptor complex	A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.		hp.json	immunoglobulin receptor complex|Fc-receptor complex|FcR complex	http://purl.obolibrary.org/obo/GO_0032997		goslim_pir
GO:0030334	biolink:BiologicalProcess	regulation of cell migration	Any process that modulates the frequency, rate or extent of cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0030334		
GO:0030335	biolink:BiologicalProcess	positive regulation of cell migration	Any process that activates or increases the frequency, rate or extent of cell migration.		hp.json	activation of cell migration|upregulation of cell migration|up regulation of cell migration|stimulation of cell migration|up-regulation of cell migration	http://purl.obolibrary.org/obo/GO_0030335		
RO:0002374	biolink:NamedThing	derived from ancestral fusion of	x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat	RO:0002374	hp.json		http://purl.obolibrary.org/obo/RO_0002374		
RO:0002375	biolink:NamedThing	in branching relationship with	A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network.		hp.json		http://purl.obolibrary.org/obo/RO_0002375		
RO:0002376	biolink:NamedThing	tributary of	x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein.	RO:0002376	hp.json	drains into	http://purl.obolibrary.org/obo/RO_0002376		ro-eco
RO:0002371	biolink:NamedThing	attached to	a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a	RO:0002371	hp.json		http://purl.obolibrary.org/obo/RO_0002371		ro-eco
PATO:0002507	biolink:NamedThing	keratinous			hp.json		http://purl.obolibrary.org/obo/PATO_0002507		
RO:0002372	biolink:NamedThing	has muscle origin	m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.	RO:0002372	hp.json		http://purl.obolibrary.org/obo/RO_0002372		
PATO:0002505	biolink:NamedThing	nucleated	A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus.		hp.json		http://purl.obolibrary.org/obo/PATO_0002505		mpath_slim|value_slim
RO:0002373	biolink:NamedThing	has muscle insertion	m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.	RO:0002373	hp.json		http://purl.obolibrary.org/obo/RO_0002373		
NCBITaxon:1437180	biolink:OrganismalEntity	Acrogymnospermae		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_1437180		
GO:0032994	biolink:CellularComponent	protein-lipid complex	A macromolecular complex containing separate protein and lipid molecules.  Separate in this context means not covalently bound to each other.		hp.json		http://purl.obolibrary.org/obo/GO_0032994		
GO:0032991	biolink:CellularComponent	protein-containing complex	Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.		hp.json	protein-protein complex|protein containing complex|protein complex|protein-protein complex|macromolecular complex|macromolecule complex	http://purl.obolibrary.org/obo/GO_0032991		goslim_agr|goslim_pir|goslim_flybase_ribbon|goslim_chembl|goslim_mouse
GO:0032990	biolink:BiologicalProcess	cell part morphogenesis	The process in which the anatomical structures of a cell part are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0032990		
PATO:0002519	biolink:NamedThing	cancellous			hp.json		http://purl.obolibrary.org/obo/PATO_0002519		
GO:0032989	biolink:BiologicalProcess	cellular component morphogenesis	The process in which cellular structures, including whole cells or cell parts, are generated and organized.		hp.json	cellular structure morphogenesis	http://purl.obolibrary.org/obo/GO_0032989		goslim_pir
GO:0032988	biolink:BiologicalProcess	ribonucleoprotein complex disassembly	The disaggregation of a protein-RNA complex into its constituent components.		hp.json	protein-RNA complex disassembly|RNA-protein complex disassembly|RNP complex disassembly	http://purl.obolibrary.org/obo/GO_0032988		
GO:0030323	biolink:BiologicalProcess	respiratory tube development	The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.		hp.json		http://purl.obolibrary.org/obo/GO_0030323		
GO:0030324	biolink:BiologicalProcess	lung development	The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.		hp.json		http://purl.obolibrary.org/obo/GO_0030324		
HP:0002506	biolink:PhenotypicFeature	Diffuse cerebral atrophy	Diffuse unlocalised atrophy affecting the cerebrum.	UMLS:C0598275	hp.json	Cerebral atrophy, diffuse	http://purl.obolibrary.org/obo/HP_0002506		
HP:0002507	biolink:PhenotypicFeature	Semilobar holoprosencephaly	A type of holoprosencephaly in which the left and right frontal and parietal lobes are fused and the interhemispheric fissure is only present posteriorly.	UMLS:C0751617|SNOMEDCT_US:253138008|MSH:D016142	hp.json		http://purl.obolibrary.org/obo/HP_0002507		
HP:0002504	biolink:PhenotypicFeature	Calcification of the small brain vessels	Deposition of calcium salts within small blood vessels of the brain.	UMLS:C4025703	hp.json		http://purl.obolibrary.org/obo/HP_0002504		
HP:0002505	biolink:PhenotypicFeature	Loss of ambulation	Inability to walk in a person who previous had the ability to walk.	UMLS:C1836843	hp.json	Loss of ability to walk	http://purl.obolibrary.org/obo/HP_0002505		
HP:0002508	biolink:PhenotypicFeature	Brainstem dysplasia	A developmental structural anomaly of the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord.	UMLS:C1855677	hp.json	Malformation of brainstem structures|Brainstem hypoplasia/dysplasia	http://purl.obolibrary.org/obo/HP_0002508		
HP:0002509	biolink:PhenotypicFeature	Limb hypertonia		UMLS:C1838391	hp.json	Increased muscle tone of arm or leg	http://purl.obolibrary.org/obo/HP_0002509		
HP:0002503	biolink:PhenotypicFeature	Spinocerebellar tract degeneration		UMLS:C1866751	hp.json	Degeneration of the spinocerebellar tracts|Spinocerebellar degeneration	http://purl.obolibrary.org/obo/HP_0002503		
HP:0002500	biolink:PhenotypicFeature	Abnormal cerebral white matter morphology	An abnormality of the cerebral white matter.	UMLS:C0948163|UMLS:C4020851|MSH:D049292	hp.json	Cortical white matter abnormalities seen on MRI|Cerebral white matter abnormalities|White matter abnormalities|White matter alterations|Abnormality of the cerebral white matter|Abnormality of subcortical white matter|Leukoaraiosis	http://purl.obolibrary.org/obo/HP_0002500		
HP:0002501	biolink:PhenotypicFeature	Spasticity of pharyngeal muscles		UMLS:C1853398	hp.json		http://purl.obolibrary.org/obo/HP_0002501		
GO:0032984	biolink:BiologicalProcess	protein-containing complex disassembly	The disaggregation of a protein-containing macromolecular complex into its constituent components.		hp.json	macromolecule complex disassembly|cellular protein complex disassembly|cellular macromolecule complex disassembly|protein complex disassembly	http://purl.obolibrary.org/obo/GO_0032984		
GO:0030320	biolink:BiologicalProcess	cellular monovalent inorganic anion homeostasis	Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0030320		
GO:0032980	biolink:BiologicalProcess	keratinocyte activation	A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines.		hp.json		http://purl.obolibrary.org/obo/GO_0032980		
GO:0030318	biolink:BiologicalProcess	melanocyte differentiation	The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.		hp.json	melanocyte cell differentiation|melanophore differentiation	http://purl.obolibrary.org/obo/GO_0030318		
GO:0030316	biolink:BiologicalProcess	osteoclast differentiation	The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.		hp.json	osteoclast cell differentiation	http://purl.obolibrary.org/obo/GO_0030316		
GO:0030317	biolink:NamedThing	flagellated sperm motility			hp.json		http://purl.obolibrary.org/obo/GO_0030317		
GO:0030312	biolink:CellularComponent	external encapsulating structure	A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space.		hp.json		http://purl.obolibrary.org/obo/GO_0030312		goslim_plant|goslim_pir|goslim_chembl|goslim_drosophila|goslim_generic
RO:0002352	biolink:NamedThing	input of	inverse of has input	RO:0002352	hp.json		http://purl.obolibrary.org/obo/RO_0002352		ro-eco|http://purl.obolibrary.org/obo/RO_0002259
RO:0002353	biolink:Protein	output_of	inverse of has output	RO:0002353	hp.json		http://purl.obolibrary.org/obo/RO_0002353		ro-eco|http://purl.obolibrary.org/obo/RO_0002259
RO:0002354	biolink:NamedThing	formed as result of			hp.json		http://purl.obolibrary.org/obo/RO_0002354		
RO:0002350	biolink:NamedThing	member of	is member of is a mereological relation between a item and a collection.	RO:0002350	hp.json		http://purl.obolibrary.org/obo/RO_0002350		
RO:0002351	biolink:NamedThing	has member	has member is a mereological relation between a collection and an item.	RO:0002351	hp.json		http://purl.obolibrary.org/obo/RO_0002351		
GO:0032970	biolink:BiologicalProcess	regulation of actin filament-based process	Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.		hp.json		http://purl.obolibrary.org/obo/GO_0032970		
GO:0030307	biolink:BiologicalProcess	positive regulation of cell growth	Any process that activates or increases the frequency, rate, extent or direction of cell growth.		hp.json	activation of cell growth|stimulation of cell growth|upregulation of cell growth|up-regulation of cell growth|up regulation of cell growth	http://purl.obolibrary.org/obo/GO_0030307		
GO:0030308	biolink:BiologicalProcess	negative regulation of cell growth	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.		hp.json	down-regulation of cell growth|down regulation of cell growth|inhibition of cell growth|downregulation of cell growth	http://purl.obolibrary.org/obo/GO_0030308		
GO:0032967	biolink:BiologicalProcess	positive regulation of collagen biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.		hp.json	positive regulation of collagen synthesis|positive regulation of collagen biosynthesis|positive regulation of collagen formation|positive regulation of collagen anabolism	http://purl.obolibrary.org/obo/GO_0032967		
GO:0032966	biolink:BiologicalProcess	negative regulation of collagen biosynthetic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.		hp.json	negative regulation of collagen biosynthesis|negative regulation of collagen anabolism|negative regulation of collagen synthesis|negative regulation of collagen formation	http://purl.obolibrary.org/obo/GO_0032966		
GO:0032965	biolink:BiologicalProcess	regulation of collagen biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.		hp.json	regulation of collagen anabolism|regulation of collagen synthesis|regulation of collagen formation|regulation of collagen biosynthesis	http://purl.obolibrary.org/obo/GO_0032965		
GO:0032964	biolink:BiologicalProcess	collagen biosynthetic process	The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).		hp.json	collagen anabolism|collagen biosynthesis|collagen synthesis|collagen formation	http://purl.obolibrary.org/obo/GO_0032964		
GO:0032963	biolink:BiologicalProcess	collagen metabolic process	The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).		hp.json	collagen metabolism	http://purl.obolibrary.org/obo/GO_0032963		
RO:0002341	biolink:NamedThing	results in transport along	Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l 	RO:0002341	hp.json		http://purl.obolibrary.org/obo/RO_0002341		
RO:0002342	biolink:NamedThing	results in transport across	Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m.	RO:0002342	hp.json		http://purl.obolibrary.org/obo/RO_0002342		http://purl.obolibrary.org/obo/valid_for_go_ontology
RO:0002343	biolink:NamedThing	results in growth of		RO:0002343	hp.json		http://purl.obolibrary.org/obo/RO_0002343		
RO:0002344	biolink:NamedThing	results in transport to from or in		RO:0002344	hp.json		http://purl.obolibrary.org/obo/RO_0002344		
RO:0002338	biolink:NamedThing	has target start location	This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination.	RO:0002338	hp.json		http://purl.obolibrary.org/obo/RO_0002338		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
RO:0002339	biolink:NamedThing	has target end location	This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l.	RO:0002339	hp.json		http://purl.obolibrary.org/obo/RO_0002339		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
RO:0002334	biolink:NamedThing	regulated by	inverse of regulates	RO:0002334	hp.json		http://purl.obolibrary.org/obo/RO_0002334		http://purl.obolibrary.org/obo/RO_0002259
RO:0002335	biolink:NamedThing	negatively regulated by	inverse of negatively regulates	RO:0002335	hp.json		http://purl.obolibrary.org/obo/RO_0002335		http://purl.obolibrary.org/obo/RO_0002259
RO:0002336	biolink:NamedThing	positively regulated by	inverse of positively regulates	RO:0002336	hp.json		http://purl.obolibrary.org/obo/RO_0002336		http://purl.obolibrary.org/obo/RO_0002259
RO:0002337	biolink:NamedThing	related via localization to	A relationship that holds via some process of localization		hp.json		http://purl.obolibrary.org/obo/RO_0002337		
CHEBI:137682	biolink:ChemicalSubstance	methylhistidine			hp.json	methylhistidines	http://purl.obolibrary.org/obo/CHEBI_137682		2_STAR
HP:0100765	biolink:PhenotypicFeature	Abnormality of the tonsils	An abnormality of the tonsils.	UMLS:C4021975	hp.json		http://purl.obolibrary.org/obo/HP_0100765		
HP:0100766	biolink:PhenotypicFeature	Abnormal lymphatic vessel morphology	A structural anomaly of the vessel that contains or conveys lymph fluid.	UMLS:C4021974	hp.json	Abnormality of the lymphatic vessels	http://purl.obolibrary.org/obo/HP_0100766		
HP:0100763	biolink:PhenotypicFeature	Abnormality of the lymphatic system	An anomaly of the lymphatic system, a network of lymphatic vessels that carry a clear fluid called lymph unidirectionally towards either the right lymphatic duct or the thoracic duct, which in turn drain into the right and left subclavian veins respectively.	UMLS:C4021976|SNOMEDCT_US:234087005|SNOMEDCT_US:111590001|UMLS:C0024228|MSH:D008206|SNOMEDCT_US:3305006|SNOMEDCT_US:362971004	hp.json	Lymphatic disease	http://purl.obolibrary.org/obo/HP_0100763		
HP:0100764	biolink:PhenotypicFeature	Lymphangioma	Lymphangiomas are rare congenital malformations consisting of focal proliferations of well-differentiated lymphatic tissue in multi cystic or sponge like structures. Lymphangioma is usually asymptomatic due to its soft consistency but compression of adjacent structures can be seen due to the mass effect of a large tumor.	SNOMEDCT_US:400178008|SNOMEDCT_US:254836000|SNOMEDCT_US:69044001|SNOMEDCT_US:253057002|NCIT:C8965|MSH:D008202|UMLS:C0024221	hp.json		http://purl.obolibrary.org/obo/HP_0100764		
HP:0100761	biolink:PhenotypicFeature	Visceral angiomatosis		UMLS:C4021977	hp.json		http://purl.obolibrary.org/obo/HP_0100761		
HP:0100762	biolink:PhenotypicFeature	Hemobilia	Bleeding into the biliary tree.	UMLS:C0018994|MSH:D006431|SNOMEDCT_US:66556007	hp.json	Haemobilia	http://purl.obolibrary.org/obo/HP_0100762		
HP:0100760	biolink:PhenotypicFeature	Clubbing of toes	Terminal broadening of the toes (distal phalanges of the toes).	SNOMEDCT_US:249808002|MSH:D003025|UMLS:C3887489|UMLS:C0009081|SNOMEDCT_US:53148007|SNOMEDCT_US:397932003	hp.json	Clubbed toes	http://purl.obolibrary.org/obo/HP_0100760		
GO:0101024	biolink:BiologicalProcess	mitotic nuclear membrane organization	A mitotic cell cycle process which results in the assembly, arrangement, or disassembly of the nuclear inner or outer membrane during mitosis.		hp.json	nuclear membrane organization involved in mitotic nuclear division	http://purl.obolibrary.org/obo/GO_0101024		
RO:0002331	biolink:NamedThing	involved in	c involved_in p if and only if c enables some process p', and p' is part of p		hp.json		http://purl.obolibrary.org/obo/RO_0002331		
GO:0101023	biolink:BiologicalProcess	vascular endothelial cell proliferation	The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0101023		
RO:0002332	biolink:NamedThing	regulates levels of	p regulates levels of c if p regulates some amount (PATO:0000070) of c	RO:0002332	hp.json		http://purl.obolibrary.org/obo/RO_0002332		
GO:0101025	biolink:BiologicalProcess	nuclear membrane biogenesis	The process in which a nuclear membrane is synthesized, aggregates, and bonds together.		hp.json		http://purl.obolibrary.org/obo/GO_0101025		
RO:0002333	biolink:NamedThing	enabled by	inverse of enables		hp.json		http://purl.obolibrary.org/obo/RO_0002333		http://purl.obolibrary.org/obo/valid_for_gocam
RO:0002327	biolink:NamedThing	enables			hp.json		http://purl.obolibrary.org/obo/RO_0002327		http://purl.obolibrary.org/obo/valid_for_go_gp2term
RO:0002328	biolink:NamedThing	functionally related to	A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities.	RO:0002328	hp.json		http://purl.obolibrary.org/obo/RO_0002328		
RO:0002329	biolink:NamedThing	part of structure that is capable of	this relation holds between c and p when c is part of some c', and c' is capable of p.		hp.json		http://purl.obolibrary.org/obo/RO_0002329		
RO:0002323	biolink:NamedThing	mereotopologically related to	A mereological relationship or a topological relationship		hp.json		http://purl.obolibrary.org/obo/RO_0002323		
RO:0002324	biolink:NamedThing	developmentally related to	A relationship that holds between entities participating in some developmental process (GO:0032502)		hp.json		http://purl.obolibrary.org/obo/RO_0002324		
PR:000006678	biolink:Protein	dihydropyrimidine dehydrogenase [NADP(+)]	A protein that is a translation product of the human DPYD gene or a 1:1 ortholog thereof.		hp.json	DHPDHase|DPD|DPYD|dihydrouracil dehydrogenase|dihydrothymine dehydrogenase	http://purl.obolibrary.org/obo/PR_000006678		
HP:0100769	biolink:PhenotypicFeature	Synovitis		UMLS:C0039103|SNOMEDCT_US:416209007|MSH:D013585	hp.json		http://purl.obolibrary.org/obo/HP_0100769		
HP:0100767	biolink:PhenotypicFeature	Abnormal placenta morphology	An abnormality of the placenta, the organ that connects the developing fetus to the uterine wall to enable nutrient uptake, waste elimination, and gas exchange.	UMLS:C1306893|SNOMEDCT_US:33552005|SNOMEDCT_US:169957005	hp.json	Placental issue|Abnormality of the placenta	http://purl.obolibrary.org/obo/HP_0100767		
HP:0100768	biolink:PhenotypicFeature	Choriocarcinoma	A malignant, trophoblastic and aggressive cancer, usually of the placenta. It is characterized by early hematogenous spread to the lungs and belongs to the far end of the spectrum of gestational trophoblastic disease (GTD), a subset of germ cell tumors.	SNOMEDCT_US:188188009|MSH:D002822|UMLS:C0008497|SNOMEDCT_US:44769000	hp.json		http://purl.obolibrary.org/obo/HP_0100768		
HP:0100776	biolink:PhenotypicFeature	Recurrent pharyngitis	An increased susceptibility to pharyngitis as manifested by a history of recurrent pharyngitis.	UMLS:C0747556	hp.json	Pharyngitis, recurrent|Recurrent sore throat	http://purl.obolibrary.org/obo/HP_0100776		
HP:0100777	biolink:PhenotypicFeature	Exostoses	An exostosis is a benign growth the projects outward from the bone surface. It is capped by cartilage, and arises from a bone that develops from cartilage.	SNOMEDCT_US:416189003|MSH:D005096|SNOMEDCT_US:80400009|UMLS:C1442903	hp.json	Formation of new noncancerous bone on top of existing bone	http://purl.obolibrary.org/obo/HP_0100777		
HP:0100774	biolink:PhenotypicFeature	Hyperostosis	Excessive growth or abnormal thickening of bone tissue.	SNOMEDCT_US:203514008|MSH:D015576|UMLS:C0020492|SNOMEDCT_US:13814009	hp.json	Bone overgrowth|Bone Hypertrophy	http://purl.obolibrary.org/obo/HP_0100774		
HP:0100775	biolink:PhenotypicFeature	Dural ectasia	A widening or ballooning of the dural sac surrounding the spinal cord usually at the lumbosacral level.	UMLS:C1851712	hp.json		http://purl.obolibrary.org/obo/HP_0100775		
HP:0100773	biolink:PhenotypicFeature	Cartilage destruction		UMLS:C4021973	hp.json	Cartilage destruction	http://purl.obolibrary.org/obo/HP_0100773		
HP:0100770	biolink:PhenotypicFeature	Hyperperistalsis	Excessively active peristalsis (wave of contraction of the tubular organs of the gastrointestinal tract) marked by excessive rapidity of the passage of food through the stomach and intestine.	SNOMEDCT_US:271838002|UMLS:C0232474|UMLS:C0857071|SNOMEDCT_US:80306002	hp.json	Stomach churning	http://purl.obolibrary.org/obo/HP_0100770		
HP:0100771	biolink:PhenotypicFeature	Hypoperistalsis	Reduced or inadequate peristalsis, with resultant slow passage of contents through the digestive tract.	SNOMEDCT_US:77853002|UMLS:C0232475|UMLS:C4020700	hp.json	Intestinal hypoperistalsis	http://purl.obolibrary.org/obo/HP_0100771		
RO:0002320	biolink:NamedThing	evolutionarily related to	A relationship that holds via some environmental process		hp.json		http://purl.obolibrary.org/obo/RO_0002320		
UBERON:0004092	biolink:AnatomicalEntity	hypothalamus-pituitary axis			hp.json		http://purl.obolibrary.org/obo/UBERON_0004092		pheno_slim
RO:0002321	biolink:NamedThing	ecologically related to	A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)		hp.json		http://purl.obolibrary.org/obo/RO_0002321		
RO:0002322	biolink:NamedThing	confers advantage in		RO:0002322	hp.json		http://purl.obolibrary.org/obo/RO_0002322		
UBERON:0004090	biolink:AnatomicalEntity	periorbital region		MA:0002875|FMA:59351	hp.json	periorbita|periorbital area	http://purl.obolibrary.org/obo/UBERON_0004090		pheno_slim
UBERON:0004099	biolink:AnatomicalEntity	joint space of elbow	Joint cavity shared by all the joints of the elbow. The elbow joint is a compound joint that actually comprises three separate joints: the joints connecting the upper and lower arm: 1) Articulatio humero-ulnaris and 2) Articulatio humero-radialis as well as the proximal joint connecting the forarm bones: 3) Articulatio radio-ulnaris proximalis. All three share a joint cavity which is highly sinuated/scalloped/coved. Joint spaces of the elbow summarizes the joint cavity shared by all three adjoining joints of the elbow joint.	FMA:38911	hp.json	synovial cavity of elbow joint	http://purl.obolibrary.org/obo/UBERON_0004099		pheno_slim
UBERON:0004098	biolink:AnatomicalEntity	tibial plateaux			hp.json		http://purl.obolibrary.org/obo/UBERON_0004098		human_reference_atlas|pheno_slim
UBERON:0004096	biolink:AnatomicalEntity	odontoid process of cervical vertebra 2	The toothlike process on the upper surface of the axis, which articulates with the atlas above[GAID].	UMLS:C0028881|EMAPA:26535|GAID:238|MESH:D009809|OpenCyc:Mx4rwIYGoJwpEbGdrcN5Y29ycA|FMA:24043|AAO:0000721|MA:0002872|NCIT:C86970	hp.json	dens axis|dens|dens of axis|axis odontoid process|odontoid process|odontoid|cervical vertebra 2 odontoid process|axis dens|odontoid process of axis	http://purl.obolibrary.org/obo/UBERON_0004096		pheno_slim
RO:0002314	biolink:NamedThing	characteristic of part of	q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w.	RO:0002314	hp.json		http://purl.obolibrary.org/obo/RO_0002314		
RO:0002315	biolink:NamedThing	results in acquisition of features of	The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity	RO:0002315	hp.json		http://purl.obolibrary.org/obo/RO_0002315		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
UBERON:5102544	biolink:AnatomicalEntity	individual digit of digitopodial skeleton	A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element.		hp.json	digit skeleton|digit	http://purl.obolibrary.org/obo/UBERON_5102544		
HP:0100778	biolink:PhenotypicFeature	Cryoglobulinemia	Increased level of cryoglobulins in the blood. Cryoglobulins are abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when serum is cooled below 37 degrees Celsius.	MSH:D003449|UMLS:C0010403|SNOMEDCT_US:30911005	hp.json	Cryoprecipitable immune complexes	http://purl.obolibrary.org/obo/HP_0100778		
HP:0100779	biolink:PhenotypicFeature	Urogenital sinus anomaly	A rare birth defect in women where the urethra and vagina both open into a common channel.	UMLS:C4021972	hp.json		http://purl.obolibrary.org/obo/HP_0100779		
HP:0100787	biolink:PhenotypicFeature	Prostate neoplasm		UMLS:C0033578|MSH:D011471|SNOMEDCT_US:126906006	hp.json		http://purl.obolibrary.org/obo/HP_0100787		
HP:0100788	biolink:PhenotypicFeature	Fused lips	Lack of separation of the upper and lower lips.	UMLS:C4021970	hp.json	Fused lips|Adhesion of upper and lower lips|Fusion of upper and lower lips	http://purl.obolibrary.org/obo/HP_0100788		hposlim_core
HP:0100785	biolink:PhenotypicFeature	Insomnia	Persistent difficulty initiating or maintaining sleep.	UMLS:C0917801|MSH:D007319|SNOMEDCT_US:193462001	hp.json	Fragmented sleep|Difficulty staying or falling asleep	http://purl.obolibrary.org/obo/HP_0100785		
HP:0100786	biolink:PhenotypicFeature	Hypersomnia		UMLS:C0917799|SNOMEDCT_US:77692006|MSH:D006970	hp.json	Excessive sleepiness	http://purl.obolibrary.org/obo/HP_0100786		
HP:0100783	biolink:PhenotypicFeature	Breast aplasia	Failure to develop and congenital absence of the breast.	UMLS:C0266009|SNOMEDCT_US:111324004	hp.json	Mammary gland aplasia|Absent breast|Congenital absence of breast	http://purl.obolibrary.org/obo/HP_0100783		
HP:0100784	biolink:PhenotypicFeature	Peripheral arteriovenous fistula		UMLS:C4021971	hp.json		http://purl.obolibrary.org/obo/HP_0100784		
HP:0100781	biolink:PhenotypicFeature	Abnormal sacroiliac joint morphology	An anomaly of the sacroiliac joint, which connects the base of the spine (sacrum) to the ilium (a hip bone).	UMLS:C0262621	hp.json	Abnormality of the sacroiliac joint	http://purl.obolibrary.org/obo/HP_0100781		
HP:0100780	biolink:PhenotypicFeature	Conjunctival hamartoma	A hamartoma (disordered proliferation of mature tissues) of the conjunctiva.	UMLS:C4021849	hp.json		http://purl.obolibrary.org/obo/HP_0100780		
GO:0042301	biolink:MolecularActivity	phosphate ion binding	Binding to a phosphate ion.		hp.json		http://purl.obolibrary.org/obo/GO_0042301		
UBERON:0004088	biolink:AnatomicalEntity	orbital region	The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present.	FMA:260119	hp.json	orbital part of face|orbital part of face|eye region|eye region|ocular region|ocular and peri-ocular region|orbital content|orbital part of eye|content of orbital part of eye	http://purl.obolibrary.org/obo/UBERON_0004088		pheno_slim
RO:0002305	biolink:NamedThing	causally upstream of, negative effect		RO:0002305	hp.json		http://purl.obolibrary.org/obo/RO_0002305		
UBERON:0004089	biolink:AnatomicalEntity	midface	The middle of the face including the nose and its associated bony structures[MW].	MA:0001910|EMAPA:32806|FMA:285406	hp.json	snout|lower face|midface/lower face	http://purl.obolibrary.org/obo/UBERON_0004089		pheno_slim
UBERON:0004086	biolink:AnatomicalEntity	brain ventricle	One of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid.	MESH:D002552|FMA:78447|UMLS:C0007799|HBA:9418|EMAPA:32674|BTO:0001442|BIRNLEX:1356|EFO:0001914|OpenCyc:Mx4rvmTY65wpEbGdrcN5Y29ycA|NCIT:C12356|MA:0000818	hp.json	brain ventricles|cerebral ventricle|region of ventricular system of brain	http://purl.obolibrary.org/obo/UBERON_0004086		pheno_slim|efo_slim|human_reference_atlas
UBERON:0004087	biolink:AnatomicalEntity	vena cava	Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart.	UMLS:C0042460|OpenCyc:Mx4rkJQ4U6gEEdudWQACs5b6Bw|MESH:D014684|SCTID:244405007|NCIT:C12817|FMA:321896|GAID:547|EMAPA:18415|Wikipedia:Venae_cavae|AAO:0010215|MA:0000068|BTO:0001438	hp.json	venae cavae|caval vein|venae cavae	http://purl.obolibrary.org/obo/UBERON_0004087		pheno_slim
UBERON:0004084	biolink:AnatomicalEntity	genital labium	One of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening.	galen:Labia|UMLS:C0227759|NCIT:C52559|EMAPA:30837|CALOHA:TS-2210|MA:0002464|FMA:321903	hp.json	genital labia|labia|labium	http://purl.obolibrary.org/obo/UBERON_0004084		pheno_slim
UBERON:0004085	biolink:AnatomicalEntity	labium majora	One of the folds of skin which form the outer lips on both sides of the vaginal opening.	UMLS:C0227760|FMA:20367|MA:0002844|NCIT:C12306|galen:LabiaMajora	hp.json	labium majus|labium majorum|labia majorum|labium majus pudendi|labium majora|labium majus pudendi	http://purl.obolibrary.org/obo/UBERON_0004085		pheno_slim
RO:0002304	biolink:NamedThing	causally upstream of, positive effect		RO:0002304	hp.json		http://purl.obolibrary.org/obo/RO_0002304		http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_gocam
GO:0140640	biolink:MolecularActivity	catalytic activity, acting on a nucleic acid	Catalytic activity that acts to modify a nucleic acid.		hp.json		http://purl.obolibrary.org/obo/GO_0140640		
HP:0100789	biolink:PhenotypicFeature	Torus palatinus	A bony protrusion present on the midline of the hard palate.	SNOMEDCT_US:244683008|SNOMEDCT_US:697945009|UMLS:C1840236|UMLS:C0266981|SNOMEDCT_US:46752004|UMLS:C0447996	hp.json	Palate exostoses|Palatal tori|Prominent midpalatal ridge|Palatal torus|Maxillary torus	http://purl.obolibrary.org/obo/HP_0100789		hposlim_core
HP:0100798	biolink:PhenotypicFeature	Fingernail dysplasia	An abnormality of the development of the fingernails.	UMLS:C4020952	hp.json	Abnormal fingernail development|Dysplastic fingernails	http://purl.obolibrary.org/obo/HP_0100798		
HP:0100799	biolink:PhenotypicFeature	Neoplasm of the middle ear	A tumor (abnormal growth of tissue) of the middle ear.	UMLS:C0345617|SNOMEDCT_US:127006003|NCIT:C3262	hp.json	Middle ear tumor|Neoplasia of the middle ear|Middle ear tumour	http://purl.obolibrary.org/obo/HP_0100799		
HP:0100796	biolink:PhenotypicFeature	Orchitis	Testicular inflammation.	SNOMEDCT_US:274718005|UMLS:C0029191|MSH:D009920	hp.json	Inflammation of testicles	http://purl.obolibrary.org/obo/HP_0100796		
HP:0100797	biolink:PhenotypicFeature	Toenail dysplasia	An abnormality of the development of the toenails.	UMLS:C3276623	hp.json	Dysplastic toenails|Abnormal toenail development	http://purl.obolibrary.org/obo/HP_0100797		
HP:0100795	biolink:PhenotypicFeature	Abnormally straight spine	The absence of the normal curvature of the vertebral column.	UMLS:C4021969	hp.json	Abnormally straight spine	http://purl.obolibrary.org/obo/HP_0100795		hposlim_core
HP:0100792	biolink:PhenotypicFeature	Acantholysis	The loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes.	UMLS:C0000887|MSH:D000051|SNOMEDCT_US:43327007|SNOMEDCT_US:441837004|UMLS:C0241128	hp.json	Nikolsky's sign	http://purl.obolibrary.org/obo/HP_0100792		
HP:0100790	biolink:PhenotypicFeature	Hernia		MSH:D006547|UMLS:C0019270|SNOMEDCT_US:52515009|SNOMEDCT_US:414403008	hp.json	Hernias	http://purl.obolibrary.org/obo/HP_0100790		
CHEBI:18408	biolink:ChemicalSubstance	cobamamide	A member of the class of cobalamins that is vitamin B12 in which the cyano group is replaced by a 5'-deoxyadenos-5'-yl moiety. It is one of the two metabolically active form of vitamin B12.	Gmelin:439994|PMID:12093296|PMID:11792214|Wikipedia:Cobamamide|CAS:13870-90-1|DrugBank:DB11191|MetaCyc:ADENOSYLCOBALAMIN|CAS:13870-90-1|KEGG:C00194|PMID:17011224|PDBeChem:B1Z|Beilstein:4122932|HMDB:HMDB0002086|Reaxys:4122932	hp.json	DBC coenzyme|5'-deoxyadenosyl vitamin B12|(5,6-dimethylbenzimidazolyl)cobamide coenzyme|5'-deoxyadenosylcobalamin|AdoCbl|cobamamidum|DMBC coenzyme|Dibencozide|cobamamid|Cobamamide|Adenosylcob(III)alamin|coenzyme B-12|adenosylcobalamin|Deoxyadenosylcobalamin|5,6-Dimethylbenzimidazolyl-5-deoxyadenosyl-cobamide|5'-deoxyadenosyl-5,6-dimethylbenzimidazolylcobamide|Coenzyme B12|Adenosylcobalamin|Calomide|Calomide|5'-Deoxy-5'-adenosylcobalamin|cobamamide|alpha-(5,6-Dimethylbenzimidazolyl)cobamide coenzyme|cobamamide|cobamide coenzyme|(5,6-Dimethylbenzimidazolyl)cobamide coenzyme|Funacomide|5,6-Dimethylbenzimidazolyl-Co-5'-deoxy-5'-adenosylcobamide|adenosylcob(III)alamin|Cobalamin coenzyme|5'-Deoxy-5'-adenosyl vitamin B12|5'-Deoxy-5'-adenosyl-5,6-dimethylbenzimidazolylcobamide|cobamamida|Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-(5'-deoxy-5'-adenosyl)cobamide|Vitamin B12 coenzyme|Coalpha-[alpha-(5,6-dimethylbenzimidazolyl)]-Cobeta-adenosylcobamide	http://purl.obolibrary.org/obo/CHEBI_18408		3_STAR
CHEBI:18401	biolink:ChemicalSubstance	phenylacetate	A monocarboxylic acid anion that is the conjugate base of phenylacetic acid.	MetaCyc:PHENYLACETATE|UM-BBD_compID:c0211|Beilstein:3539899|Reaxys:3539899|Gmelin:327522	hp.json	phenylacetic acid anion|phenylacetate anion|2-phenylacetate|phenylacetate(1-)|phenylacetate|2-phenylethanoate	http://purl.obolibrary.org/obo/CHEBI_18401		3_STAR
CHEBI:79389	biolink:ChemicalSubstance	monovalent inorganic anion	Any inorganic anion with a valency of one.		hp.json	monovalent inorganic anions	http://purl.obolibrary.org/obo/CHEBI_79389		3_STAR
CHEBI:79388	biolink:ChemicalSubstance	divalent inorganic anion	Any inorganic anion with a valency of two.		hp.json	divalent inorganic anions	http://purl.obolibrary.org/obo/CHEBI_79388		3_STAR
CHEBI:79387	biolink:ChemicalSubstance	trivalent inorganic anion	Any inorganic anion with a valency of three.		hp.json	trivalent inorganic anions	http://purl.obolibrary.org/obo/CHEBI_79387		3_STAR
CHEBI:3098	biolink:ChemicalSubstance	bile acid	Any member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.	KEGG:C01558	hp.json	5beta-bile acids|Bile salt|Gallensaeuren|Bile acid|bile acids|5beta-bile acid|Gallensaeure	http://purl.obolibrary.org/obo/CHEBI_3098		3_STAR
GO:0042321	biolink:BiologicalProcess	negative regulation of circadian sleep/wake cycle, sleep	Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.		hp.json	down-regulation of circadian sleep/wake cycle, sleep|down regulation of circadian sleep/wake cycle, sleep|negative regulation of sleep|inhibition of circadian sleep/wake cycle, sleep|downregulation of circadian sleep/wake cycle, sleep	http://purl.obolibrary.org/obo/GO_0042321		
GO:0042320	biolink:BiologicalProcess	regulation of circadian sleep/wake cycle, REM sleep	Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep.		hp.json	regulation of REM sleep	http://purl.obolibrary.org/obo/GO_0042320		
GO:0042322	biolink:BiologicalProcess	negative regulation of circadian sleep/wake cycle, REM sleep	Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.		hp.json	inhibition of circadian sleep/wake cycle, REM sleep|negative regulation of REM sleep|downregulation of circadian sleep/wake cycle, REM sleep|down-regulation of circadian sleep/wake cycle, REM sleep|down regulation of circadian sleep/wake cycle, REM sleep	http://purl.obolibrary.org/obo/GO_0042322		
GO:0042325	biolink:BiologicalProcess	regulation of phosphorylation	Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.		hp.json		http://purl.obolibrary.org/obo/GO_0042325		
GO:0042327	biolink:BiologicalProcess	positive regulation of phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.		hp.json	up regulation of phosphorylation|activation of phosphorylation|stimulation of phosphorylation|upregulation of phosphorylation|up-regulation of phosphorylation	http://purl.obolibrary.org/obo/GO_0042327		
GO:0042326	biolink:BiologicalProcess	negative regulation of phosphorylation	Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.		hp.json	down-regulation of phosphorylation|down regulation of phosphorylation|downregulation of phosphorylation|inhibition of phosphorylation	http://purl.obolibrary.org/obo/GO_0042326		
GO:0042330	biolink:BiologicalProcess	taxis	The directed movement of a motile cell or organism in response to an external stimulus.	Wikipedia:Taxis	hp.json	directed movement in response to stimulus	http://purl.obolibrary.org/obo/GO_0042330		
PR:000016043	biolink:Protein	T-cell acute lymphocytic leukemia protein 1	A protein that is a translation product of the human TAL1 gene or a 1:1 ortholog thereof.		hp.json	class A basic helix-loop-helix protein 17|bHLHa17|TAL1|SCL|TAL-1|TCL5|T-cell leukemia/lymphoma protein 5|stem cell protein|BHLHA17	http://purl.obolibrary.org/obo/PR_000016043		
GO:0030397	biolink:BiologicalProcess	membrane disassembly	The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.		hp.json	membrane degradation|membrane breakdown|membrane catabolism	http://purl.obolibrary.org/obo/GO_0030397		
GO:0042359	biolink:BiologicalProcess	vitamin D metabolic process	The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).		hp.json	cholecalciferol metabolism|ergocalciferol metabolism|ergocalciferol metabolic process|cholecalciferol metabolic process|calciferol metabolic process|vitamin D metabolism|calciferol metabolism	http://purl.obolibrary.org/obo/GO_0042359		
CHEBI:18361	biolink:ChemicalSubstance	diphosphate(4-)		PDBeChem:DPO|CAS:14000-31-8|Gmelin:26938|KEGG:C00013	hp.json	mu-oxido-bis(trioxidophosphate)(4-)|mu-oxo-hexaoxodiphosphate|pyrophosphate ion|P2O7(4-)|Diphosphate|[O3POPO3](4-)|PPi|Pyrophosphate|Pyrophosphat|Diphosphat|DIPHOSPHATE|diphosphate	http://purl.obolibrary.org/obo/CHEBI_18361		3_STAR
GO:0150033	biolink:BiologicalProcess	negative regulation of protein localization to lysosome	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.		hp.json		http://purl.obolibrary.org/obo/GO_0150033		
GO:0150032	biolink:BiologicalProcess	positive regulation of protein localization to lysosome	Any process that activates or increases the frequency, rate or extent of protein localization to lysosome.		hp.json		http://purl.obolibrary.org/obo/GO_0150032		
GO:0150031	biolink:BiologicalProcess	regulation of protein localization to lysosome	Any process that modulates the frequency, rate or extent of protein localization to lysosome.		hp.json		http://purl.obolibrary.org/obo/GO_0150031		
UBERON:0004141	biolink:AnatomicalEntity	heart tube	An epithelial tube that will give rise to the mature heart.	NCIT:C34161|AAO:0010411|EFO:0003526|ZFA:0000360|TAO:0000360|EMAPA:32685|XAO:0000337	hp.json	endocardial tube|endocardial heart tube|embryonic heart tube	http://purl.obolibrary.org/obo/UBERON_0004141		vertebrate_core|pheno_slim|efo_slim
HP:0002497	biolink:PhenotypicFeature	Spastic ataxia		MSH:C564815|UMLS:C1849156	hp.json		http://purl.obolibrary.org/obo/HP_0002497		
UBERON:0004142	biolink:AnatomicalEntity	outflow tract septum	The outflow tract septum is a partition in the outflow tract.	XAO:0004141	hp.json		http://purl.obolibrary.org/obo/UBERON_0004142		
UBERON:0004140	biolink:AnatomicalEntity	primary heart field	A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.	XAO:0004185	hp.json	FHF|primary heart field|first heart field|primary heart field|PHF|heart field	http://purl.obolibrary.org/obo/UBERON_0004140		
HP:0100808	biolink:PhenotypicFeature	Gastric diverticulum	An outpouching of the gastric wall.	MSH:D013273|UMLS:C0038355|SNOMEDCT_US:75198005	hp.json	Stomach diverticulum	http://purl.obolibrary.org/obo/HP_0100808		
HP:0100809	biolink:PhenotypicFeature	Scalp tenderness	Pain or discomfort of the scalp elicited by palpation.	MEDDRA:10039521|SNOMEDCT_US:75851004|UMLS:C0151206|UMLS:C0240940|UMLS:C4073183	hp.json	Allodynia of scalp|Scalp pain|Scalp hypersensitivity|Scalp tenderness	http://purl.obolibrary.org/obo/HP_0100809		
HP:0002490	biolink:PhenotypicFeature	Increased CSF lactate	Increased concentration of lactate in the cerebrospinal fluid.	UMLS:C1167918	hp.json	Hyperlactatorachia|Increased CSF lactic acid|Increased cerebrospinal fluid lactate	http://purl.obolibrary.org/obo/HP_0002490		
HP:0100806	biolink:PhenotypicFeature	Sepsis	Systemic inflammatory response to infection.	UMLS:C0036690|MSH:D018805	hp.json	Infection in blood stream	http://purl.obolibrary.org/obo/HP_0100806		
CHEBI:57966	biolink:ChemicalSubstance	beta-alanine zwitterion	Zwitterionic form of beta-alanine arising from transfer of a proton from the carboxy to the amino group; major species at pH 7.3.	Gmelin:454332	hp.json	3-ammoniopropanoate|beta-alanine|3-azaniumylpropanoate	http://purl.obolibrary.org/obo/CHEBI_57966		3_STAR
HP:0100807	biolink:PhenotypicFeature	Long fingers	The middle finger is more than 2 SD above the mean for newborns 27 to 41 weeks EGA or above the 97th centile for children from birth to 16 years of age AND the five digits retain their normal length proportions relative to each other (i.e., it is not the case that the middle finger is the only lengthened digit), or, Fingers that appear disproportionately long compared to the palm of the hand.	UMLS:C1858091	hp.json	Long fingers	http://purl.obolibrary.org/obo/HP_0100807		
HP:0002491	biolink:PhenotypicFeature	Spasticity of facial muscles	Spasticity of one or more muscles innervated by the facial nerve.	UMLS:C4280571|UMLS:C4280570|UMLS:C1853404	hp.json	Spasticity of the facial muscles|Increased stiffness of facial muscles|Increased tone of facial muscles	http://purl.obolibrary.org/obo/HP_0002491		
HP:0100804	biolink:PhenotypicFeature	Ungual fibroma	Flesh-colored papule in or around the nail bed. Ungual fibromas may be periungual (arising under the proximal nail fold) or subungual (originating under the nail plate).	UMLS:C0442880|SNOMEDCT_US:264561009	hp.json	Koenen tumor|Koenen's tumor|Parungual fibromas|Periungual fibroma|Koenen's tumour|Koenen tumour	http://purl.obolibrary.org/obo/HP_0100804		
HP:0100805	biolink:PhenotypicFeature	obsolete Precocious menopause			hp.json		http://purl.obolibrary.org/obo/HP_0100805		
HP:0002494	biolink:PhenotypicFeature	Abnormal rapid eye movement sleep	Abnormality of REM sleep. Phases of REM sleep are characterized by desynchronized EEG patterns, increases in heart rate and blood pressure, sympathetic activation, and a profound loss of muscle tonus except for the eye and middle-ear muscles. There are then phases of rapid eye movements.	SNOMEDCT_US:69020003|UMLS:C0392188	hp.json	Abnormal REM sleep	http://purl.obolibrary.org/obo/HP_0002494		
HP:0100802	biolink:PhenotypicFeature	Malposition of the stomach	Abnormal anatomical location of the stomach. This feature may be due to intestinal malrotation.	UMLS:C1402983	hp.json	Gastric malposition|Abnormal stomach location|Gastric ectopia	http://purl.obolibrary.org/obo/HP_0100802		
UBERON:0004148	biolink:AnatomicalEntity	cardiac vein	Vein of heart that drains the myocardium.	SCTID:277726009|UMLS:C0226737|ZFA:0005814|EHDAA2:0004507|NCIT:C12878|Wikipedia:Coronary_circulation|UMLS:C0226654|FMA:12846|EMAPA:37137|NCIT:C12882|galen:CoronaryVein	hp.json	cardiac vein|coronary vein|coronary vein|heart vein|coronary vein|vein of heart	http://purl.obolibrary.org/obo/UBERON_0004148		pheno_slim
HP:0100803	biolink:PhenotypicFeature	Abnormality of the periungual region	An abnormality of the region around the nails of the fingers or toes.	UMLS:C4021966	hp.json		http://purl.obolibrary.org/obo/HP_0100803		
HP:0002495	biolink:PhenotypicFeature	Impaired vibratory sensation	A decrease in the ability to perceive vibration. Clinically, this is usually tested with a tuning fork which vibrates at 128 Hz and is applied to bony prominences such as the malleoli at the ankles or the metacarpal-phalangeal joints. There is a slow decay of vibration from the tuning fork. The degree of vibratory sense loss can be crudely estimated by counting the number of seconds that the examiner can perceive the vibration longer than the patient.	SNOMEDCT_US:130980003|UMLS:C1295585	hp.json	Decreased vibratory sense|Hypopallesthesia|Diminished vibratory sense|Impaired vibratory sense|Impaired vibratory sensation|Decreased vibration sense	http://purl.obolibrary.org/obo/HP_0002495		
UBERON:0004145	biolink:AnatomicalEntity	outflow tract	The outflow tract is the portion of the heart through which blood flows into the arteries.	EMAPA:16346|XAO:0004139|VHOG:0000670|EHDAA:798|MA:0000100|EHDAA:464|EHDAA2:0001351	hp.json	cardiac outflow tract|arterial (outflow) pole|cardiac outflow tract|arterial (outflow) pole|heart outflow tract	http://purl.obolibrary.org/obo/UBERON_0004145		pheno_slim
HP:0100800	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the pancreas	A congenital underdevelopment (aplasia or hypoplasia) of the pancreas.	UMLS:C4021968	hp.json	Absent/small pancreas|Absent/underdeveloped pancreas	http://purl.obolibrary.org/obo/HP_0100800		
HP:0002492	biolink:PhenotypicFeature	Morphological abnormality of the corticospinal tract	Abnormality of the corticospinal tract, which is the chief element of the pyramidal system (the principle motor tract) and is the only direct connection between the cerebrum and the spinal cord.	UMLS:C4025704|UMLS:C4020852	hp.json	Abnormality of the corticospinal tract|Involvement of the corticospinal pathways	http://purl.obolibrary.org/obo/HP_0002492		
HP:0002493	biolink:PhenotypicFeature	Upper motor neuron dysfunction	A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs.	UMLS:C1839042|UMLS:C1504405	hp.json	Pyramidal tract dysfunction|Corticospinal tract dysfunction	http://purl.obolibrary.org/obo/HP_0002493		
HP:0100801	biolink:PhenotypicFeature	Pancreatic aplasia	Aplasia of the pancreas.	UMLS:C4021967	hp.json	Absent pancreas	http://purl.obolibrary.org/obo/HP_0100801		
UBERON:0004146	biolink:AnatomicalEntity	His-Purkinje system	The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.		hp.json	His-Purkinji network|HPS|ventricular conduction system|VCS	http://purl.obolibrary.org/obo/UBERON_0004146		
HP:0100810	biolink:PhenotypicFeature	Pointed helix		UMLS:C4020951	hp.json	Pointed ear|Spock ear|Elfin ear|Vulcan ear|Spock's ear	http://purl.obolibrary.org/obo/HP_0100810		
UBERON:0004133	biolink:AnatomicalEntity	salivatory nucleus	.		hp.json	salivary nucleus	http://purl.obolibrary.org/obo/UBERON_0004133		
UBERON:0004130	biolink:AnatomicalEntity	cerebellar layer	A cortical cell layer of the cerebellum. Examples: the granular (inner+outer) layer, molecular layer, Purkinje cell layer, and the ventricular layer of the embryo.	FMA:83141|BIRNLEX:880|EMAPA:35212|UMLS:C1707522|MA:0000201|NCIT:C49137	hp.json	layer of cerebellar cortex|cell layer of cerebellar cortex|layer of cerebellum|cytoarchitectural part of the cerebellar cortex|gray matter layer of cerebellum	http://purl.obolibrary.org/obo/UBERON_0004130		pheno_slim
CHEBI:70959	biolink:ChemicalSubstance	3-methylhistidine	A methylhistidine in which the methyl group is located at N-3.	PMID:24009031|PMID:24681531|PMID:22770225|Reaxys:83652	hp.json	3-methylhistidine|2-amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid|3-methyl-DL-histidine	http://purl.obolibrary.org/obo/CHEBI_70959		3_STAR
CHEBI:70958	biolink:ChemicalSubstance	1-methylhistidine	A methylhistidine in which the methyl group is located at N-1.	Reaxys:611190|PMID:22770225	hp.json	1-methyl-DL-histidine|1-methylhistidine|2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid	http://purl.obolibrary.org/obo/CHEBI_70958		3_STAR
GO:0140694	biolink:BiologicalProcess	non-membrane-bounded organelle assembly	The aggregation, arrangement and bonding together of a set of components to form a non-membrane-bounded organelle.		hp.json	non-membrane-enclosed organelle assembly|non-membrane-bounded organelle formation|non-membrane-enclosed organelle formation	http://purl.obolibrary.org/obo/GO_0140694		
HP:0100819	biolink:PhenotypicFeature	Intestinal fistula	An abnormal connection between the gut and another hollow organ, such as the bladder, urethra, vagina, or other regions of the gastrointestinal tract.	UMLS:C0021833|SNOMEDCT_US:38851006|MEDDRA:10022647|MSH:D007412	hp.json		http://purl.obolibrary.org/obo/HP_0100819		hposlim_core
HP:0100817	biolink:PhenotypicFeature	Renovascular hypertension	The presence of hypertension related to stenosis of the renal artery.	MSH:D006978|UMLS:C0020545|SNOMEDCT_US:123799005	hp.json	Hypertension due to renal artery hyperplasia	http://purl.obolibrary.org/obo/HP_0100817		
NBO:0000993	biolink:NamedThing	decreased frequency of drinking			hp.json		http://purl.obolibrary.org/obo/NBO_0000993		
HP:0100818	biolink:PhenotypicFeature	Long thorax	Increased inferior to superior extent of the thorax.	SNOMEDCT_US:298710001|UMLS:C0575484	hp.json	Long rib cage	http://purl.obolibrary.org/obo/HP_0100818		hposlim_core
UBERON:0004139	biolink:AnatomicalEntity	cardiogenic plate	The first recognizable structure derived from the heart field.	VHOG:0000975|EMAPA:16106|EHDAA2:0000215	hp.json	cardiac crescent|cardiogenic crescent|myocardial plate|heart rudiment	http://purl.obolibrary.org/obo/UBERON_0004139		pheno_slim
HP:0100816	biolink:PhenotypicFeature	Lip hyperpigmentation		UMLS:C4021963	hp.json	Increased pigmentation on the lips|Hyperpigmentation of lip vermillion|Darkening of skin of the lips	http://purl.obolibrary.org/obo/HP_0100816		
UBERON:0006799	biolink:AnatomicalEntity	glandular epithelium	An epithelium that is composed primarily of secretory cells.	NCIT:C43370|BTO:0002991|NCIT:C45715|UMLS:C0682578|UMLS:C1708242	hp.json		http://purl.obolibrary.org/obo/UBERON_0006799		
HP:0100813	biolink:PhenotypicFeature	Testicular torsion	Testicular torsion is when the spermatic cord to a testicle twists, cutting off the blood supply. The most common symptom is acute testicular pain.	SNOMEDCT_US:49198006|SNOMEDCT_US:81996005|UMLS:C0037856|MSH:D013086	hp.json	Spermatic cord torsion	http://purl.obolibrary.org/obo/HP_0100813		
HP:0100814	biolink:PhenotypicFeature	Blue nevus		UMLS:C4020699|MSH:D049328|UMLS:C0265985|SNOMEDCT_US:40467008	hp.json	Congenital dermal melanocytosis|Mongolian spot	http://purl.obolibrary.org/obo/HP_0100814		
HP:0100811	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the colon	Congenital absence or underdevelopment of the colon.	UMLS:C4021964	hp.json	Absent/underdeveloped colon|Absent/small colon	http://purl.obolibrary.org/obo/HP_0100811		
HP:0100812	biolink:PhenotypicFeature	Halitosis	Noticeably unpleasant odors exhaled in breathing.	MSH:D006209|SNOMEDCT_US:79879001|MEDDRA:10006326|UMLS:C0018520	hp.json	Bad breath|Foetor ex ore	http://purl.obolibrary.org/obo/HP_0100812		hposlim_core
HP:0100820	biolink:PhenotypicFeature	Glomerulopathy	Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron.	UMLS:C0268731|SNOMEDCT_US:197679002	hp.json	Diseased glomeruli	http://purl.obolibrary.org/obo/HP_0100820		
HP:0100821	biolink:PhenotypicFeature	Urethrocele	The prolapse of the female urethra into the vagina.	SNOMEDCT_US:12068006|UMLS:C0238502|ICD-9:618.03	hp.json		http://purl.obolibrary.org/obo/HP_0100821		
CHEBI:57947	biolink:ChemicalSubstance	creatine zwitterion	Zwitterionic form of creatine arising from transfer of a proton from the carboxy to the guanidino group; major species at pH 7.3.	MetaCyc:CREATINE	hp.json	creatine|{[amino(iminio)methyl](methyl)amino}acetate	http://purl.obolibrary.org/obo/CHEBI_57947		3_STAR
CHEBI:57948	biolink:ChemicalSubstance	5-oxo-D-prolinate	The conjugate base of 5-oxo-D-proline; major species at pH 7.3.		hp.json	5-oxo-D-prolinate(1-)|5-oxo-D-proline|5-oxo-D-prolinate|5-oxo-D-prolinate anion|(2R)-5-oxopyrrolidine-2-carboxylate	http://purl.obolibrary.org/obo/CHEBI_57948		3_STAR
UBERON:0004121	biolink:AnatomicalEntity	ectoderm-derived structure	An anatomical structure that develops (entirely or partially) from the ectoderm.	FBbt:00025990	hp.json	ectodermal deriviative	http://purl.obolibrary.org/obo/UBERON_0004121		grouping_class
HP:0002476	biolink:PhenotypicFeature	Primitive reflex	The primitive reflexes are a group of behavioural motor responses which are found in normal early development, are subsequently inhibited, but may be released from inhibition by cerebral, usually frontal, damage. They are thus part of a broader group of reflexes which reflect release phenomena, such as exaggerated stretch reflexes and extensor plantars. They do however involve more complex motor responses than such simple stretch reflexes, and are often a normal feature in the neonate or infant.	UMLS:C1838319	hp.json	Archaic reflex|Primitive reflexes	http://purl.obolibrary.org/obo/HP_0002476		
UBERON:0004122	biolink:AnatomicalEntity	genitourinary system	Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction.	OpenCyc:Mx4rQRpVMgAKEdyHxgDggVfs8g|BILA:0000122|galen:GenitoUrinarySystem|EV:0100094|VHOG:0000286|EMAPA:16367|SCTID:278861008|AAO:0000624|NCIT:C12810|UMLS:C0042066|FMA:280610|EHDAA:1013|GAID:362|MESH:D014566|XAO:0000140|BTO:0003091|EFO:0003864	hp.json	genito-urinary system|UG tract|genitourinary tract|GU tract|urogenital tract|urogenital system|Urogenitalsystem	http://purl.obolibrary.org/obo/UBERON_0004122		efo_slim|pheno_slim
HP:0002474	biolink:PhenotypicFeature	Expressive language delay	A delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.	UMLS:C0454641|UMLS:C1847610|UMLS:C4280573|SNOMEDCT_US:229734008	hp.json	Deficit in expressive language|Communication delay	http://purl.obolibrary.org/obo/HP_0002474		
HP:0002475	biolink:PhenotypicFeature	Myelomeningocele	Protrusion of the meninges and portions of the spinal cord through a defect of the vertebral column.	SNOMEDCT_US:203994003|Fyler:4309|SNOMEDCT_US:414667000|UMLS:C0025312|MSH:D008591	hp.json	Spina bifida cystica|Meningomyelocele	http://purl.obolibrary.org/obo/HP_0002475		
UBERON:0004120	biolink:AnatomicalEntity	mesoderm-derived structure	An anatomical structure that develops (entirely or partially) from the mesoderm.	FBbt:00025998	hp.json	mesodermal derivative	http://purl.obolibrary.org/obo/UBERON_0004120		grouping_class
HP:0002478	biolink:PhenotypicFeature	Progressive spastic quadriplegia		UMLS:C1859736	hp.json	Progressive spastic quadriparesis	http://purl.obolibrary.org/obo/HP_0002478		
HP:0100828	biolink:PhenotypicFeature	Increased T cell count	An abnormal increase in the total number of T cells detected in the blood.	UMLS:C4021960	hp.json	Increase in T cell number|Increase in T cell count	http://purl.obolibrary.org/obo/HP_0100828		
HP:0100829	biolink:PhenotypicFeature	Galactorrhea	Spontaneous flow of milk from the breast, unassociated with childbirth or nursing.	UMLS:C3665358|MSH:D005687	hp.json	Galactorrhoea|Spontaneous milk flow from breast	http://purl.obolibrary.org/obo/HP_0100829		
HP:0100826	biolink:PhenotypicFeature	Neoplasm of the nail	A tumor (abnormal growth of tissue) of the nail.	UMLS:C4021961|NCIT:C3262	hp.json	Nail tumor|Nail tumour	http://purl.obolibrary.org/obo/HP_0100826		
HP:0100827	biolink:PhenotypicFeature	Lymphocytosis	Increase in the number or proportion of lymphocytes in the blood.	UMLS:C0024282|SNOMEDCT_US:67023009|MSH:D008218	hp.json	High lymphocyte count	http://purl.obolibrary.org/obo/HP_0100827		
UBERON:0004128	biolink:AnatomicalEntity	optic vesicle	The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA].	FMA:293357|EHDAA2:0001320|SCTID:362864008|ZFA:0000050|XAO:0000228|TAO:0000050|Wikipedia:Optic_vesicles|VHOG:0000165|UMLS:C0231106|EMAPA:16540|AAO:0011039|NCIT:C34236	hp.json	evagination|optic vesicles|eye vesicle|ocular vesicle	http://purl.obolibrary.org/obo/UBERON_0004128		pheno_slim|vertebrate_core
HP:0002472	biolink:PhenotypicFeature	Small cerebral cortex	Reduced size of the cerebral cortex.	UMLS:C1837503	hp.json	Decreased volume of cerebral cortex	http://purl.obolibrary.org/obo/HP_0002472		
CHEBI:18376	biolink:ChemicalSubstance	dermatan sulfate	Any of a group of glycosaminoglycans with repeating units consisting of variously sulfated beta1->4-linked L-iduronyl-(alpha1->3)-N-acetyl-D-galactosamine units.	CAS:24967-94-0|CAS:24967-94-0|KEGG:C00426|Beilstein:8390617	hp.json	beta-Heparin|Dermatan L-iduronate|Chondroitin sulfate B	http://purl.obolibrary.org/obo/CHEBI_18376		3_STAR
UBERON:0004126	biolink:AnatomicalEntity	trabecular layer of ventricle	A myocardium trabecular layer that is part of a cardiac ventricle.	ZFA:0005060|TAO:0005060|FMA:83511	hp.json	trabecular cardiac ventricle muscle|myocardium of region of ventricle|ventricular trabecular myocardium	http://purl.obolibrary.org/obo/UBERON_0004126		vertebrate_core
HP:0100825	biolink:PhenotypicFeature	Cheilitis	Inflammation of the lip.	MSH:D002613|SNOMEDCT_US:7847004|UMLS:C0007971|UMLS:C4280288	hp.json	Inflammation of the lips|Red and sore lips	http://purl.obolibrary.org/obo/HP_0100825		hposlim_core
UBERON:0004123	biolink:AnatomicalEntity	myocardial layer	Any of the layers of the myocardium. Example: compact layer, trabecular layer.	EMAPA:37475|MA:0000080	hp.json	layer of myocardium|myocardium layer	http://purl.obolibrary.org/obo/UBERON_0004123		non_informative|pheno_slim
HP:0100822	biolink:PhenotypicFeature	Rectocele	A Rectocele results from a tear in the rectovaginal septum (which is normally a tough, fibrous, sheet-like divider between the rectum and vagina). Rectal tissue bulges through this tear and into the vagina as a hernia. There are two main causes of this tear: childbirth, and hysterectomy.	MSH:D020047|SNOMEDCT_US:62730001|SNOMEDCT_US:447072005|ICD-9:618.04|UMLS:C0149771	hp.json		http://purl.obolibrary.org/obo/HP_0100822		
HP:0002470	biolink:PhenotypicFeature	Nonprogressive cerebellar ataxia		UMLS:C1845029	hp.json		http://purl.obolibrary.org/obo/HP_0002470		
UBERON:0004124	biolink:AnatomicalEntity	myocardium trabecular layer	The layer of the myocardium composed of projections of contractile myocytes. The trabecular layer is bounded internally by the endocardium. In zebrafish, unlike the trabeculations of higher vertebrates, both atrial and ventricular trabeculae have more strut-like character, and are more uniform without apparent regional differences[ZFA].	TAO:0005059|MA:0002866|EFO:0003706|ZFA:0005059	hp.json	myocardial trabeculae carneae|myocardial trabecular layer|heart muscle trabecula|heart muscle trabeculae|trabeculae|trabecular layer|trabecula of heart muscle	http://purl.obolibrary.org/obo/UBERON_0004124		efo_slim|vertebrate_core
HP:0100823	biolink:PhenotypicFeature	Genital hernia		UMLS:C4021962	hp.json		http://purl.obolibrary.org/obo/HP_0100823		
HP:0100831	biolink:PhenotypicFeature	Abnormality of vitamin K metabolism	Vitamin K is a fat-soluble vitamin with a role in promoting the coagulation cascade.	UMLS:C4021958	hp.json	Abnormality of vitamin K metabolism	http://purl.obolibrary.org/obo/HP_0100831		
HP:0100832	biolink:PhenotypicFeature	Vitreous floaters	Deposits of various size, shape, consistency, refractive index, and motility within the eye's vitreous humour, which is normally transparent.	SNOMEDCT_US:15013002|SNOMEDCT_US:162278001|UMLS:C0016242|SNOMEDCT_US:420999000|UMLS:C1720491	hp.json	Flitting flies|Spots in front of eyes|Vitreous condensations|Mouches volantes|Myodesopsia|Vitreous veils|Myodeopsia|Eye floaters|Vitreous opacities|Vitreous debris	http://purl.obolibrary.org/obo/HP_0100832		
HP:0100830	biolink:PhenotypicFeature	Round ear		UMLS:C4021959	hp.json	Round ear	http://purl.obolibrary.org/obo/HP_0100830		
UBERON:0004109	biolink:AnatomicalEntity	cortex of humerus	The outer or sperficial part of the humerus.	FMA:31542	hp.json	compact bone of humerus|humerus cortical bone|humerus compact bone|cortex of the humerus	http://purl.obolibrary.org/obo/UBERON_0004109		pheno_slim
NBO:0000961	biolink:NamedThing	increased frequency of drinking			hp.json		http://purl.obolibrary.org/obo/NBO_0000961		
HP:0002487	biolink:PhenotypicFeature	Hyperkinetic movements	Motor hyperactivity with excessive movement of muscles of the body as a whole.	SNOMEDCT_US:45352006|SNOMEDCT_US:44548000|MSH:D013035|UMLS:C0037763|MSH:D006948|UMLS:C0424295	hp.json	Muscle spasms|Hyperkinesis|Hyperkinesia	http://purl.obolibrary.org/obo/HP_0002487		
UBERON:0004110	biolink:AnatomicalEntity	midnasal cavity	An anatomical cavity that is the combination of the cavity between the nares and the choanae[HP,modified].	FMA:59675	hp.json		http://purl.obolibrary.org/obo/UBERON_0004110		pheno_slim
UBERON:0004111	biolink:AnatomicalEntity	anatomical conduit	Any tube, opening or passage that connects two distinct anatomical spaces.	FMA:242873|SCTID:346902003|EHDAA2:0003080|Wikipedia:Foramen|AEO:0000080	hp.json	foramen|opening|foramina|ostium|foramina|ostia	http://purl.obolibrary.org/obo/UBERON_0004111		
HP:0002488	biolink:PhenotypicFeature	Acute leukemia	A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).	SNOMEDCT_US:91855006|UMLS:C0085669|SNOMEDCT_US:24072005|UMLS:C4280572	hp.json	Acute leukemias|Acute leukaemia|Acute blood cancer	http://purl.obolibrary.org/obo/HP_0002488		
HP:0002486	biolink:PhenotypicFeature	Myotonia	An involuntary and painless delay in the relaxation of skeletal muscle following contraction or electrical stimulation.	SNOMEDCT_US:3434004|UMLS:C0027125|MSH:D009222	hp.json	Delayed relaxation of muscle fibers after contraction|Delayed relaxation of muscle fibres after contraction	http://purl.obolibrary.org/obo/HP_0002486		
CHEBI:70979	biolink:ChemicalSubstance	N-isobutyrylglycine	An N-acylglycine in which the acyl group is specified as isobutryl.	PMID:17712735|PMID:14723814|PMID:22770225|Reaxys:1762789|PMID:7360517|HMDB:HMDB0000730|PMID:23062437|PMID:7408214|PMID:20836999|PMID:8548022|PMID:20528888	hp.json	isobutyrylglycine|N-(2-methylpropanoyl)glycine|isobutanoylglycine|[(2-methylpropanoyl)amino]acetic acid|N-isobutanoylglycine	http://purl.obolibrary.org/obo/CHEBI_70979		3_STAR
CHEBI:33984	biolink:ChemicalSubstance	fucose	Any deoxygalactose that is deoxygenated at the 6-position.	KEGG:C00382|CAS:7724-73-4|PMID:12651883	hp.json	Fuc|6-Deoxygalactose|fucose|6-deoxygalactose|Fucose	http://purl.obolibrary.org/obo/CHEBI_33984		3_STAR
HP:0100839	biolink:PhenotypicFeature	Hepatic agenesis	Absence of the liver owing to a failure of the liver to develop.	SNOMEDCT_US:3650004|UMLS:C0266258	hp.json	Liver agenesis|Failed liver development	http://purl.obolibrary.org/obo/HP_0100839		
UBERON:0004118	biolink:AnatomicalEntity	vasculature of iris	A vasculature that is part of a iris [Automatically generated definition].	ZFA:0005568	hp.json	iris vasculature|iris blood vessels|iris vascular network|vascular network of iris	http://purl.obolibrary.org/obo/UBERON_0004118		pheno_slim
HP:0002480	biolink:PhenotypicFeature	Hepatic encephalopathy	Central nervous system dysfunction in association with liver failure and characterized clinically (depending on degree of severity) by lethargy, confusion, nystagmus, decorticate posturing, spasticity, and bilateral Babinski reflexes.	SNOMEDCT_US:13920009|UMLS:C0019151|MSH:D006501|SNOMEDCT_US:449902003	hp.json		http://purl.obolibrary.org/obo/HP_0002480		
UBERON:0004119	biolink:AnatomicalEntity	endoderm-derived structure	An anatomical structure that develops (entirely or partially) from the endoderm.		hp.json		http://purl.obolibrary.org/obo/UBERON_0004119		grouping_class
UBERON:0004116	biolink:AnatomicalEntity	nerve of tympanic cavity	A nerve that is part of a tympanic cavity [Automatically generated definition].	EMAPA:37777|MA:0001222	hp.json	tympanic cavity nerves|middle ear anatomical cavity nerve|nerve of middle ear cavity|middle ear cavity nerve|nerve of anatomical cavity of middle ear|cavity of middle ear nerve|anatomical cavity of middle ear nerve|nerve of middle ear anatomical cavity|tympanic cavity nerve|nerve of cavity of middle ear	http://purl.obolibrary.org/obo/UBERON_0004116		
HP:0100837	biolink:PhenotypicFeature	Atrophodermia vermiculata	Symmetrical vermiform facial atrophy that affects mainly the forehead, the chin, the ear lobes and helices. Atrophodermia vermiculata is characterized by erythema and follicular plugs on the cheeks, developing into painless reticular impressions.	SNOMEDCT_US:400059005|SNOMEDCT_US:400126005|MSH:C537412|UMLS:C0263428	hp.json	Vermiculata atrophoderma	http://purl.obolibrary.org/obo/HP_0100837		
HP:0100838	biolink:PhenotypicFeature	Recurrent cutaneous abscess formation	An increased susceptibility to cutaneous abscess formation, as manifested by a medical history of recurrent cutaneous abscesses.	UMLS:C4021957	hp.json		http://purl.obolibrary.org/obo/HP_0100838		
CHEBI:18367	biolink:ChemicalSubstance	phosphate(3-)	A phosphate ion that is the conjugate base of hydrogenphosphate.	Beilstein:3903772|Reaxys:3903772|Gmelin:1997|CAS:14265-44-2|PDBeChem:PO4|CAS:14265-44-2|KEGG:C00009	hp.json	[PO4](3-)|PHOSPHATE ION|Phosphate|tetraoxophosphate(3-)|tetraoxophosphate(V)|phosphate|tetraoxidophosphate(3-)|PO4(3-)|Orthophosphate	http://purl.obolibrary.org/obo/CHEBI_18367		3_STAR
UBERON:0004117	biolink:AnatomicalEntity	pharyngeal pouch	An internal pocketing of pharyngeal endoderm that contacts a region of ectoderm (a pharyngeal cleft) and interdigitates in the anterior and posterior directions with the pharyngeal arches.	AAO:0011113|XAO:0000282|Wikipedia:Pharyngeal_pouch_(embryology)|EHDAA:1086|NCIT:C34252|EMAPA:32752|VHOG:0001203|EHDAA:617|UMLS:C0231067|EHDAA:1669|FMA:293063|ZFA:0001106|EHDAA:579|TAO:0001106|EFO:0003627|SCTID:34674002	hp.json	pharyngeal pouches|visceral pouch|branchial pouch|branchial pouch|visceral pouches	http://purl.obolibrary.org/obo/UBERON_0004117		pheno_slim|efo_slim|vertebrate_core
HP:0100835	biolink:PhenotypicFeature	Benign neoplasm of the central nervous system		UMLS:C0347509|SNOMEDCT_US:92048008	hp.json	Benign neoplasm of the CNS	http://purl.obolibrary.org/obo/HP_0100835		
UBERON:0004114	biolink:AnatomicalEntity	tympanic cavity	Small cavity surrounding the bones of the middle ear.	BTO:0002098|FMA:56461|EHDAA2:0004119|EV:0100358|EMAPA:37778	hp.json	tympanum|middle-ear cavity|anatomical cavity of middle ear|cavitas tympanica|cavitas tympani|middle ear cavity|cavity of middle ear	http://purl.obolibrary.org/obo/UBERON_0004114		
HP:0002483	biolink:PhenotypicFeature	Bulbar signs		UMLS:C1856507	hp.json		http://purl.obolibrary.org/obo/HP_0002483		
HP:0100836	biolink:PhenotypicFeature	Malignant neoplasm of the central nervous system	A tumor that originates in the pineal gland, has moderate cellularity and tends to form rosette patterns.	UMLS:C0348374|SNOMEDCT_US:372062007	hp.json	Malignant neoplasm of the CNS	http://purl.obolibrary.org/obo/HP_0100836		
UBERON:0004115	biolink:AnatomicalEntity	blood vessel of tympanic cavity	A blood vessel that is part of a tympanic cavity [Automatically generated definition].	EMAPA:37775|MA:0001219	hp.json	blood vessel of middle ear cavity|anatomical cavity of middle ear blood vessel|tympanic cavity blood vessel|blood vessel of middle ear anatomical cavity|cavity of middle ear blood vessel|blood vessel of anatomical cavity of middle ear|middle ear cavity blood vessel|middle ear blood vessel|blood vessel of cavity of middle ear|middle ear anatomical cavity blood vessel	http://purl.obolibrary.org/obo/UBERON_0004115		
HP:0100833	biolink:PhenotypicFeature	Neoplasm of the small intestine	The presence of a neoplasm of the small intestine.	SNOMEDCT_US:126832004|UMLS:C0345832|NCIT:C3262	hp.json	Small intestine tumour|Small intestine tumor	http://purl.obolibrary.org/obo/HP_0100833		
UBERON:0004113	biolink:AnatomicalEntity	muscle of auditory ossicle	A muscle of the tympanic cavity that attaches to an auditory ossicle.	EMAPA:37776|UMLS:C1513769|FMA:49026|MA:0000256|NCIT:C33148	hp.json	ossicular muscle|muscle of middle ear|tympanic cavity muscle|muscle of auditory ossicles|auditory ossicles muscle|muscle of tympanic cavity	http://purl.obolibrary.org/obo/UBERON_0004113		
HP:0100834	biolink:PhenotypicFeature	Neoplasm of the large intestine	The presence of a neoplasm of the large intestine.	MSH:D015179|SNOMEDCT_US:126837005|UMLS:C0009404|NCIT:C3262	hp.json	Large intestine tumor|Large intestine tumour	http://purl.obolibrary.org/obo/HP_0100834		
HP:0100842	biolink:PhenotypicFeature	Septo-optic dysplasia	Underdevelopment of the optic nerve and absence of the septum pellucidum.	SNOMEDCT_US:7611002|UMLS:C0338503|MSH:D025962	hp.json	De Morsier syndrome	http://purl.obolibrary.org/obo/HP_0100842		
HP:0100843	biolink:PhenotypicFeature	obsolete Glioblastoma			hp.json		http://purl.obolibrary.org/obo/HP_0100843		
HP:0100840	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the eyebrow	Absence or underdevelopment of the eyebrow.	UMLS:C3551430|UMLS:C4021956|UMLS:C2266639|UMLS:C1848765	hp.json	Absence of eyebrow|Lack of eyebrow|Sparse to absent eyebrows|Missing eyebrow|Hypotrophic eyebrow|Agenesis of eyebrow|Sparse or absent eyebrows|Sparse/absent eyebrows	http://purl.obolibrary.org/obo/HP_0100840		
HP:0100841	biolink:PhenotypicFeature	Microgastria	A developmental anomaly wtih a small tubular or saccular midline stomach.	SNOMEDCT_US:83714006|UMLS:C0266150	hp.json		http://purl.obolibrary.org/obo/HP_0100841		
PR:P00439	biolink:Protein	phenylalanine-4-hydroxylase (human)	A phenylalanine-4-hydroxylase that is encoded in the genome of human.	UniProtKB:P00439	hp.json	PAH|Phe-4-monooxygenase (human)|hPAH	http://purl.obolibrary.org/obo/PR_P00439		
UBERON:0004180	biolink:AnatomicalEntity	mammary gland fat	The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts.	EMAPA:35539|MA:0002911	hp.json	fat tissue of lactiferous gland|adipose tissue of lactiferous gland|mammary gland adipose tissue|lactiferous gland fatty tissue|lobe of mammary gland adipose tissue|fatty tissue of lobe of mammary gland|mammary gland fat tissue|fatty tissue of mammary gland|lobe of mammary gland fat tissue|lobe of breast adipose tissue|fat tissue of lobe of mammary gland|mammary gland fatty tissue|fat tissue of mammary gland|fat tissue of lobe of breast|lobe of mammary gland fatty tissue|lobe of breast fat tissue|fatty tissue of lactiferous gland|adipose tissue of mammary gland|lactiferous gland adipose tissue|lactiferous gland fat tissue|fatty tissue of lobe of breast|lobe of breast fatty tissue	http://purl.obolibrary.org/obo/UBERON_0004180		
UBERON:0004188	biolink:AnatomicalEntity	glomerular epithelium	The glomerular epithelium is an epithelial tissue that covers the outer surfaces of the glomerulus. The glomerular epithelium consists of both parietal and visceral epithelium. Metanephric glomerular parietal epithelial cells are specialized epithelial cells that form tight junctions as a barrier to protein transport. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros.	BTO:0001515|EMAPA:35458|MA:0002847	hp.json	kidney glomerular epithelium|epithelium of kidney glomerulus|epithelium of glomerulus|glomerular epithelial cell|epithelium of renal glomerulus	http://purl.obolibrary.org/obo/UBERON_0004188		human_reference_atlas
UBERON:0004185	biolink:AnatomicalEntity	endodermal part of digestive tract	A portions of the gut that is derived from endoderm.	EMAPA:32930	hp.json	gut endoderm|endodermal gut	http://purl.obolibrary.org/obo/UBERON_0004185		
UBERON:0004183	biolink:AnatomicalEntity	placental labyrinth blood vessel	The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.		hp.json	labyrinthine layer blood vessel|placenta labyrinth blood vessel|blood vessel of placenta labyrinth|blood vessel of labyrinthine layer|blood vessel of labyrinthine layer of placenta|labyrinthine layer of placenta blood vessel	http://purl.obolibrary.org/obo/UBERON_0004183		
UBERON:0004184	biolink:AnatomicalEntity	prostate gland stroma	The prostate gland stroma is made up of the mesenchymal or fibroblast cells of the prostate gland.	NCIT:C13104|EMAPA:35714|MA:0002912|FMA:45719|UMLS:C1521760	hp.json	stroma of glandular part of prostate|prostatic stroma|stroma of prostate gland|stroma of prostate|prostate stroma	http://purl.obolibrary.org/obo/UBERON_0004184		human_reference_atlas
UBERON:0004182	biolink:AnatomicalEntity	mammary gland cord	The solid cord of epithelial cells that emerges from the mammary bud and grows down from the primary mammary mesenchyme and into a second stromal compartment, the fat pad precursor, beneath the dermis.		hp.json	mammary cord|mammary sprout|lactiferous gland cord	http://purl.obolibrary.org/obo/UBERON_0004182		
HP:0100848	biolink:PhenotypicFeature	Neoplasm of the male external genitalia	A tumor (abnormal growth of tissue) of the male external genitalia.	NCIT:C3262|UMLS:C4020950	hp.json	Neoplasia of the male external genitalia	http://purl.obolibrary.org/obo/HP_0100848		
HP:0100849	biolink:PhenotypicFeature	Neoplasm of the scrotum	A tumor (abnormal growth of tissue) of the scrotum.	SNOMEDCT_US:126905005|UMLS:C0341790|NCIT:C3262	hp.json	Scrotum tumour|Neoplasia of the scrotum|Scrotum tumor	http://purl.obolibrary.org/obo/HP_0100849		
HP:0100847	biolink:PhenotypicFeature	Palmoplantar pustulosis	A chronic, relapsing, pustular eruption that is localized to the palms and soles.	MSH:D011565|UMLS:C0030246|SNOMEDCT_US:27520001|MEDDRA:10050185	hp.json	Palmoplantar pustules|Pustulosis palmaris et plantaris|Pustulosis of palms and soles	http://purl.obolibrary.org/obo/HP_0100847		
CHEBI:18310	biolink:ChemicalSubstance	alkane	An acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, and therefore consisting entirely of hydrogen atoms and saturated carbon atoms.	KEGG:C01371	hp.json	alcane|alkanes|Alkan|RH|alcano|an alkane|alkane|alcanos|Alkane|alcanes	http://purl.obolibrary.org/obo/CHEBI_18310		3_STAR
NCBITaxon:8782	biolink:OrganismalEntity	Aves		GC_ID:1	hp.json	birds|birds|avian	http://purl.obolibrary.org/obo/NCBITaxon_8782		
HP:0100844	biolink:PhenotypicFeature	Pancreatic fistula		MSH:D010185|UMLS:C0030290|SNOMEDCT_US:25803005	hp.json		http://purl.obolibrary.org/obo/HP_0100844		
UBERON:0004189	biolink:AnatomicalEntity	glomerular endothelium	The glomerular endothelium is an epithelial tissue that covers the internal surfaces of the glomerulus.	BTO:0004631	hp.json	endothelium of renal glomerulus|renal glomerulus endothelium	http://purl.obolibrary.org/obo/UBERON_0004189		
HP:0100845	biolink:PhenotypicFeature	Anaphylactic shock	An acute hypersensitivity reaction due to exposure to a previously encountered antigen.	MSH:D000707|SNOMEDCT_US:39579001|UMLS:C0002792	hp.json	Anaphylaxis	http://purl.obolibrary.org/obo/HP_0100845		
HP:0100853	biolink:PhenotypicFeature	Hypoplastic areola	Underdevelopment of the areola, the circular area of pigmented skin surrounding the nipple.	UMLS:C3276032	hp.json	Hypoplastic areolae	http://purl.obolibrary.org/obo/HP_0100853		hposlim_core
HP:0100854	biolink:PhenotypicFeature	Aplasia of the musculature	Absence of the musculature.	UMLS:C4021955	hp.json	Absent musculature	http://purl.obolibrary.org/obo/HP_0100854		
HP:0100851	biolink:PhenotypicFeature	Abnormal emotion/affect behavior	An abnormality of emotional behaviour.	UMLS:C4020949	hp.json	Abnormal emotion/affect behaviour	http://purl.obolibrary.org/obo/HP_0100851		
HP:0100852	biolink:PhenotypicFeature	Abnormal fear/anxiety-related behavior	An abnormality of fear/anxiety-related behavior, which may relate to either abnormally reduced fear/anxiety-related response or increased fear/anxiety-related response.	UMLS:C4018849	hp.json	Abnormal fear/anxiety-related behaviour	http://purl.obolibrary.org/obo/HP_0100852		
HP:0100850	biolink:PhenotypicFeature	Neoplasm of the penis	A tumor (abnormal growth of tissue) of the penis.	UMLS:C0030849|NCIT:C3262|MSH:D010412|SNOMEDCT_US:126896003	hp.json	Penis tumor|Penis tumour|Neoplasia of the penis	http://purl.obolibrary.org/obo/HP_0100850		
UBERON:0004176	biolink:AnatomicalEntity	external genitalia	The external genitalia are the outer sex organs, such as the penis or vulva in mammals.	FMA:45643|SCTID:362207005	hp.json	external reproductive organ|external sex organ|external genitalia	http://purl.obolibrary.org/obo/UBERON_0004176		organ_slim|pheno_slim
UBERON:0004177	biolink:AnatomicalEntity	hemopoietic organ	Organ that is part of the hematopoietic system.	BTO:0004605|FMA:7143|EMAPA:37665|MA:0000747|SCTID:361338006	hp.json	hematopoeitic organ|organa haemopoietica organ|lymph organ|haemopoietic system organ|hematopoietic system organ|organ of haematological system|organ of organa haemopoietica|hematopoeitic or lymphoid organ|lymphoid organ|organ of hematopoietic system|haematological system organ|organ of haemopoietic system	http://purl.obolibrary.org/obo/UBERON_0004177		organ_slim|pheno_slim
UBERON:0004175	biolink:AnatomicalEntity	internal genitalia	The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.	FMA:45652	hp.json	internal sex organ|internal reproductive organ|internal genitalia|internal genitals	http://purl.obolibrary.org/obo/UBERON_0004175		organ_slim|pheno_slim
HP:0100859	biolink:PhenotypicFeature	Dilatation of superior mesenteric artery	Abnormal outpouching or sac-like dilatation in the wall of the superior mesenteric artery .	UMLS:C0264974|SNOMEDCT_US:65498003	hp.json	Superior mesenteric artery aneurysm	http://purl.obolibrary.org/obo/HP_0100859		
HP:0100857	biolink:PhenotypicFeature	Flat sella turcica	An abnormally flat sella turcica.	UMLS:C4021952	hp.json		http://purl.obolibrary.org/obo/HP_0100857		
HP:0100858	biolink:PhenotypicFeature	Dilatation of celiac artery	Abnormal outpouching or sac-like dilatation in the wall of the celiac artery.	UMLS:C0264969|SNOMEDCT_US:111290000	hp.json	Celiac artery aneurysm|Dilatation of coeliac artery|Coeliac artery aneurysm	http://purl.obolibrary.org/obo/HP_0100858		
HP:0100855	biolink:PhenotypicFeature	Triceps hypoplasia	Hypoplasia of the triceps muscle.	UMLS:C4021954	hp.json	Underdeveloped triceps|Small triceps	http://purl.obolibrary.org/obo/HP_0100855		
UBERON:0004178	biolink:AnatomicalEntity	aorta smooth muscle tissue	The nonstriated, involuntary muscle tissue located in the wall of the aorta.	NCIT:C49191|EFO:0002775|BTO:0001685|MA:0000702|UMLS:C1706825|CALOHA:TS-0048|EMAPA:35135	hp.json	aortic smooth muscle|aorta non-striated muscle|aorta smooth muscle	http://purl.obolibrary.org/obo/UBERON_0004178		pheno_slim|efo_slim
HP:0100856	biolink:PhenotypicFeature	Poorly ossified vertebrae	Decreased ossification of the vertebral bodies.	UMLS:C4021953	hp.json		http://purl.obolibrary.org/obo/HP_0100856		
HP:0100864	biolink:PhenotypicFeature	Short femoral neck	An abnormally short femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft).	UMLS:C1836184	hp.json	Short femoral necks|Short neck of thighbone|Hypoplastic femoral neck|Hypoplasia of the femoral neck	http://purl.obolibrary.org/obo/HP_0100864		hposlim_core
HP:0100865	biolink:PhenotypicFeature	Broad ischia	Increased width of the ischium, which forms the lower and back part of the hip bone.	UMLS:C1836868	hp.json		http://purl.obolibrary.org/obo/HP_0100865		
HP:0100862	biolink:PhenotypicFeature	Aplasia of the femoral head		UMLS:C4021950	hp.json	Absent femoral head	http://purl.obolibrary.org/obo/HP_0100862		
HP:0100863	biolink:PhenotypicFeature	Aplasia of the femoral neck		UMLS:C4021949	hp.json	Absent neck of thighbone	http://purl.obolibrary.org/obo/HP_0100863		
HP:0100860	biolink:PhenotypicFeature	Dilatation of Inferior mesenteric artery	Abnormal outpouching or sac-like dilatation in the wall of the inferior mesenteric artery .	SNOMEDCT_US:195289005|UMLS:C0340625	hp.json	Inferior mesenteric artery aneurysm	http://purl.obolibrary.org/obo/HP_0100860		
HP:0100861	biolink:PhenotypicFeature	Sclerotic vertebral body	Increase in bone density of the vertebral body.	UMLS:C4021951	hp.json	Vertebral body sclerosis	http://purl.obolibrary.org/obo/HP_0100861		
CHEBI:33937	biolink:ChemicalSubstance	macronutrient	Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals.		hp.json	macronutrients	http://purl.obolibrary.org/obo/CHEBI_33937		3_STAR|1_STAR
UBERON:0004161	biolink:AnatomicalEntity	septum transversum	A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG].	UMLS:C0231004|SCTID:308819008|VHOG:0000019|EHDAA2:0001829|NCIT:C34296|EMAPA:16318|Wikipedia:Septum_transversum|EHDAA:736|FMA:295593	hp.json	transverse septum|transverse septum	http://purl.obolibrary.org/obo/UBERON_0004161		pheno_slim
UBERON:0004160	biolink:AnatomicalEntity	proepicardium	An embryonic group of progenitor cells that forms from an outpouching of the septum transversum near the venous pole of the heart and gives rise to the epicardium.	ZFA:0005808|EMAPA:36025	hp.json	proepicardial cluster|proepicardial organ	http://purl.obolibrary.org/obo/UBERON_0004160		
PR:P00450	biolink:Protein	ceruloplasmin (human)	A ceruloplasmin that is encoded in the genome of human.	UniProtKB:P00450	hp.json	CP|hCP|ferroxidase (human)	http://purl.obolibrary.org/obo/PR_P00450		
HP:0100869	biolink:PhenotypicFeature	Palmar telangiectasia	The presence of telangiectases on the skin of palm of hand.	UMLS:C4020948	hp.json	Teleangiectases of palms|Telangiectases of palms and soles	http://purl.obolibrary.org/obo/HP_0100869		
HP:0100866	biolink:PhenotypicFeature	Short iliac bones	Underdevelopment of the iliac bones.	UMLS:C1849063	hp.json	Short pelvis bones	http://purl.obolibrary.org/obo/HP_0100866		
HP:0100867	biolink:PhenotypicFeature	Duodenal stenosis	The narrowing or partial blockage of a portion of the duodenum.	UMLS:C0238093|MSH:C535720|SNOMEDCT_US:73120006|UMLS:C1860791|MEDDRA:10050094	hp.json	Duodenal stenosis/atresia	http://purl.obolibrary.org/obo/HP_0100867		hposlim_core
HP:0100875	biolink:PhenotypicFeature	Hemimacroglossia	Increased length and width of one half of the tounge.	UMLS:C4021947|UMLS:C4280287	hp.json	Hyperplasia of half of the tongue|Hemiglossal hypertrophy|Increased size of half of the tongue|Hypertrophy of half of the tongue|Large half of tongue|Hemiglossal hyperplasia	http://purl.obolibrary.org/obo/HP_0100875		
HP:0100876	biolink:PhenotypicFeature	Infra-orbital crease	Skin crease extending from below the inner canthus laterally along the malar process of the maxilla and zygoma.	UMLS:C1857280	hp.json	Infraorbital creases|Infraorbital crease|Crease in skin under the eye|Underorbital skin creases|Groove in skin under the eye	http://purl.obolibrary.org/obo/HP_0100876		hposlim_core
HP:0100874	biolink:PhenotypicFeature	Thick hair	Increased density of hairs, i.e., and elevated number of hairs per unit area.	UMLS:C4073184	hp.json	Increased hair density|Increased follicular density|Thick hair	http://purl.obolibrary.org/obo/HP_0100874		hposlim_core
HP:0100871	biolink:PhenotypicFeature	Abnormal palm morphology	An abnormality of the palm, that is, of the front of the hand.	UMLS:C4021948	hp.json	Abnormality of the palm	http://purl.obolibrary.org/obo/HP_0100871		
HP:0100872	biolink:PhenotypicFeature	Abnormality of the plantar skin of foot	An abnormality of the plantar part of foot, that is of the soles of the feet.	UMLS:C4020946	hp.json	Minor feet anomalies	http://purl.obolibrary.org/obo/HP_0100872		
HP:0100870	biolink:PhenotypicFeature	Plantar telangiectasia	Telangiectases (small dilated blood vessels) located on the skin of sole of foot.	UMLS:C4020947	hp.json	Teleangiectases of soles|Plantar teleangiectasia|Telangiectases of soles	http://purl.obolibrary.org/obo/HP_0100870		
UBERON:0004151	biolink:AnatomicalEntity	cardiac chamber	A cardiac chamber surrounds an enclosed cavity within the heart.	SCTID:276456008|FMA:7095|OpenCyc:Mx4rmexpjPdAEduAAAAOpmP6tw	hp.json	chamber of heart|heart chamber	http://purl.obolibrary.org/obo/UBERON_0004151		
CHEBI:33942	biolink:ChemicalSubstance	ribose	Any aldopentose where the open-chain form has all the hydroxy groups on the same side in the Fischer projection. Occurrs in two enantiomeric forms, D- and L-ribose, of which only the former is found in nature.		hp.json	Rib|ribose|ribo-pentose	http://purl.obolibrary.org/obo/CHEBI_33942		3_STAR
CHEBI:79346	biolink:ChemicalSubstance	anionic ganglioside	Any carbohydrate acid derivative anion obtained by deprotonation of at least one of the neuraminosyl carboxy groups of a ganglioside.		hp.json	ganglioside anion	http://purl.obolibrary.org/obo/CHEBI_79346		3_STAR
HP:0100879	biolink:PhenotypicFeature	Enlarged ovaries		UMLS:C0392039|SNOMEDCT_US:66998000	hp.json	Enlarged ovaries	http://purl.obolibrary.org/obo/HP_0100879		
HP:0100877	biolink:PhenotypicFeature	Renal diverticulum	Cystic, urine-containing intrarenal cavities lined with transitional cell epithelium that communicate through a narrow channel with the collecting system.	UMLS:C2315541|SNOMEDCT_US:433036004	hp.json	Caliceal diverticulum|Pelvic diverticulum|Renal pelvic diverticulum	http://purl.obolibrary.org/obo/HP_0100877		
HP:0100878	biolink:PhenotypicFeature	Enlarged uterus		SNOMEDCT_US:198319004|UMLS:C0151994	hp.json	Enlarged uterus	http://purl.obolibrary.org/obo/HP_0100878		
GO:0032956	biolink:BiologicalProcess	regulation of actin cytoskeleton organization	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.		hp.json	regulation of actin cytoskeleton organization and biogenesis|regulation of actin cytoskeleton organisation	http://purl.obolibrary.org/obo/GO_0032956		
UBERON:0006719	biolink:AnatomicalEntity	lateral pterygoid muscle	Pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors, is innervated by the lateral pterygoid nerve branches, and attaches to the condylar process of the mandible and temporomandibular joint (TMJ) capsule, and the cranial base.	FMA:49015|MFMO:0000074|UMLS:C1517045|EMAPA:25140|NCIT:C32570|MA:0002360	hp.json	m. pterygoideus lateralis|pterygoid lateralis|m. pterygoideus externus|pterygoideus externus|musculus pterygoideus externus|lateral pteregoid muscle|musculus pterygoides lateralis|pterygoideus lateral muscle|external pterygoid muscle|pterygoideus lateral|lateral pteregoid|lateral pterygoid|musculus pterygoideus lateralis|pterygoideus externus muscle	http://purl.obolibrary.org/obo/UBERON_0006719		pheno_slim
UBERON:0006718	biolink:AnatomicalEntity	medial pterygoid muscle	The medial pterygoid is a pharyngeal arch 1 muscle that participates in oral/pharyngeal behaviors and is innervated by the nerve to the medial pterygoid and attaches to the cranial base and the medial side of the mandibular angle.	BTO:0005226|UMLS:C1512882|MFMO:0000083|NCIT:C32861|EMAPA:25141|FMA:49011|MA:0002361	hp.json	internal pterygoid muscle|pterygoid medialis|internal pterygoid|pterygoideus internus|pterygoideus medial|medial pterygoid|musculus pterygoideus medialis|pterygoidei internus|musculus pterygoideus internus|pterygoideus medialis	http://purl.obolibrary.org/obo/UBERON_0006718		pheno_slim
UBERON:0006717	biolink:AnatomicalEntity	autopodial skeleton	The collection of all skeletal elements in an autopodium region.	VSAO:0005019	hp.json	autopod skeleton|skeletal parts of autopod|autopodial skeleton|autopodium|skeleton of autopod	http://purl.obolibrary.org/obo/UBERON_0006717		
UBERON:0006716	biolink:AnatomicalEntity	mesopodium region	The third segment of the limb, including either the wrist segment (carpus) or the ankle segment (tarsus).		hp.json	carpus/tarsus|mesopod|mesopodial limb segment|mesopodial segment	http://purl.obolibrary.org/obo/UBERON_0006716		
HP:0002418	biolink:PhenotypicFeature	Abnormal midbrain morphology	An abnormality of the midbrain, which has as its parts the tectum, cerebral peduncle, midbrain tegmentum and cerebral aqueduct.	UMLS:C4021755	hp.json	Abnormality of the mesencephalon|Abnormal shape of midbrain|Abnormality of the midbrain|Abnormality of midbrain morphology	http://purl.obolibrary.org/obo/HP_0002418		
HP:0002419	biolink:PhenotypicFeature	Molar tooth sign on MRI	An abnormal appearance of the midbrain in axial magnetic resonance imaging in which the elongated superior cerebellar peduncles give the midbrain an appearance reminiscent of a molar or wisdom tooth.	UMLS:C1865060	hp.json	Molar tooth sign|Molar tooth sign on brain imaging|Molar tooth sign on imaging	http://purl.obolibrary.org/obo/HP_0002419		
HP:0002416	biolink:PhenotypicFeature	Subependymal cysts	Cerebral cysts, usually located in the wall of the caudate nucleus or in the caudothalamic groove. They are found in up to 5.2% of all neonates, using transfontanellar ultrasound in the first days of life.	UMLS:C1833431	hp.json	Subependymal germinolytic cyst|Subependymal pseudocyst	http://purl.obolibrary.org/obo/HP_0002416		
HP:0002410	biolink:PhenotypicFeature	Aqueductal stenosis	Stenosis of the cerebral aqueduct (also known as the mesencephalic duct, aqueductus mesencephali, or aqueduct of Sylvius), which connects the third cerebral ventricle in the diencephalon to the fourth ventricle, which is between the pons and cerebellum.	MSH:D006849|UMLS:C2936786	hp.json	Aqueduct stenosis|Narrowing of aqueduct of Sylvius|Aqueduct of Sylvius stenosis	http://purl.obolibrary.org/obo/HP_0002410		
HP:0002411	biolink:PhenotypicFeature	Myokymia	Myokymia consists of involuntary, fine, continuous, undulating contractions that spread across the affected striated muscle.	SNOMEDCT_US:27678003|UMLS:C0684219|MSH:D020385	hp.json		http://purl.obolibrary.org/obo/HP_0002411		
HP:0002414	biolink:PhenotypicFeature	Spina bifida	Incomplete closure of the embryonic neural tube, whereby some vertebral arches remain unfused and open. The mildest form is spina bifida occulta, followed by meningocele and meningomyelocele.	SNOMEDCT_US:67531005|Fyler:4157|UMLS:C0080178|MSH:D016135	hp.json	Split spine	http://purl.obolibrary.org/obo/HP_0002414		
HP:0002415	biolink:PhenotypicFeature	Leukodystrophy	Leukodystrophy refers to deterioration of white matter of the brain resulting from degeneration of myelin sheaths in the CNS. Their basic defect is directly related to the synthesis and maintenance of myelin membranes. Symmetric white matter involvement at MRI is a typical finding in patients with leukodystrophies.	SNOMEDCT_US:192781003|UMLS:C0023520	hp.json	Degeneration of white matter of brain	http://purl.obolibrary.org/obo/HP_0002415		
UBERON:0006726	biolink:AnatomicalEntity	outer canthus	A corner of the outer (lateral) part of an eye.	EHDAA2:0000910|VHOG:0001571|UMLS:C1711189|MA:0001264|EMAPA:37458|EHDAA:9039|NCIT:C49597|FMA:59315	hp.json	lateral canthus of eye|temporal canthus|lateral angle of eye|lateral canthus|outer canthi|lateral palpebral commissure	http://purl.obolibrary.org/obo/UBERON_0006726		
UBERON:0006723	biolink:AnatomicalEntity	cochlear modiolus	The central cone shaped core of spongy bone about which turns the spiral canal.	NCIT:C33135|FMA:61278|MA:0001182|UMLS:C0229503|BTO:0001693|EMAPA:35575	hp.json	modiolus cochleae|modiolus of cochlea|cochlea modiolus|columella cochleae|modiolus	http://purl.obolibrary.org/obo/UBERON_0006723		organ_slim|pheno_slim
UBERON:0006722	biolink:AnatomicalEntity	manubrium of malleus	The handle of the malleus; the portion that extends downward, inward, and backward from the neck of the malleus; it is embedded throughout its length in the tympanic membrane.	MA:0002985|FMA:52760	hp.json	manubrium mallei|malleal manubrium|manubrium of malleus|manubrium of malleus|handle of malleus|malleus handle|malleus handle|malleus manubrium	http://purl.obolibrary.org/obo/UBERON_0006722		pheno_slim
UBERON:0006720	biolink:AnatomicalEntity	pterygoid muscle		AAO:0010730|EMAPA:25139|MESH:D011626|GAID:147	hp.json	pterygoid|pterygoideus muscle|pterygoideus	http://purl.obolibrary.org/obo/UBERON_0006720		grouping_class
GO:0032946	biolink:BiologicalProcess	positive regulation of mononuclear cell proliferation	Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.		hp.json	upregulation of mononuclear cell proliferation|up regulation of mononuclear cell proliferation|positive regulation of PBMC proliferation|stimulation of mononuclear cell proliferation|positive regulation of peripheral blood mononuclear cell proliferation|up-regulation of mononuclear cell proliferation|activation of mononuclear cell proliferation	http://purl.obolibrary.org/obo/GO_0032946		
GO:0032945	biolink:BiologicalProcess	negative regulation of mononuclear cell proliferation	Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.		hp.json	negative regulation of peripheral blood mononuclear cell proliferation|negative regulation of PBMC proliferation	http://purl.obolibrary.org/obo/GO_0032945		
GO:0032944	biolink:BiologicalProcess	regulation of mononuclear cell proliferation	Any process that modulates the frequency, rate or extent of mononuclear cell proliferation.		hp.json	regulation of peripheral blood mononuclear cell proliferation|regulation of PBMC proliferation	http://purl.obolibrary.org/obo/GO_0032944		
GO:0032943	biolink:BiologicalProcess	mononuclear cell proliferation	The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.		hp.json	peripheral blood mononuclear cell proliferation|PBMC proliferation	http://purl.obolibrary.org/obo/GO_0032943		
GO:0032941	biolink:BiologicalProcess	secretion by tissue	The controlled release of a substance by a tissue.		hp.json	expulsion of gland contents|tissue secretion	http://purl.obolibrary.org/obo/GO_0032941		
HP:0002427	biolink:PhenotypicFeature	Expressive aphasia	Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it.	SNOMEDCT_US:229665008|UMLS:C0003550|UMLS:C0917814|SNOMEDCT_US:229654003|MSH:D001039|SNOMEDCT_US:328681008	hp.json	Loss of expressive speech|Non-fluent aphasia|Broca's aphasia|Motor aphasia	http://purl.obolibrary.org/obo/HP_0002427		
HP:0002421	biolink:PhenotypicFeature	Poor head control	Difficulty to maintain correct position of the head while standing or sitting.	UMLS:C1836038	hp.json	Poor head control	http://purl.obolibrary.org/obo/HP_0002421		
CHEBI:55370	biolink:ChemicalSubstance	imidazolidinone	An imidazolidine containing one or more oxo groups.		hp.json	imidazolidinones	http://purl.obolibrary.org/obo/CHEBI_55370		3_STAR
HP:0002425	biolink:PhenotypicFeature	Anarthria	A defect in the motor ability that enables speech.	UMLS:C0234517|SNOMEDCT_US:48257004	hp.json	Loss of articulate speech	http://purl.obolibrary.org/obo/HP_0002425		
HP:0002423	biolink:PhenotypicFeature	Long-tract signs		UMLS:C1865903	hp.json	Long tract signs	http://purl.obolibrary.org/obo/HP_0002423		
UBERON:0006715	biolink:AnatomicalEntity	radio-ulna	Paired, long bones of endochondral origin formed by the fusion of the radius and ulna.	AAO:0000901|XAO:0003209	hp.json	radioulna|radius-ulna|radius+ulna	http://purl.obolibrary.org/obo/UBERON_0006715		
GO:0032940	biolink:BiologicalProcess	secretion by cell	The controlled release of a substance by a cell.	Wikipedia:Secretion	hp.json	cellular secretion	http://purl.obolibrary.org/obo/GO_0032940		
GO:0150099	biolink:BiologicalProcess	neuron-glial cell signaling	Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signalling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine.		hp.json	neurone-glia signaling|neuron-glia signaling|neuron-glial cell signalling|neurone-glial cell signalling|neurone-glial cell signaling|neuron-glia signalling|neurone-glia signalling	http://purl.obolibrary.org/obo/GO_0150099		
GO:0150098	biolink:BiologicalProcess	glial cell-neuron signaling	Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signalling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum.		hp.json	glial cell-neurone singaling|glia-neuron signaling|glia-neurone signaling|glia-neurone signalling|glia-neuron signalling|glial cell-neurone signalling|glial cell- neuron signalling	http://purl.obolibrary.org/obo/GO_0150098		
GO:0019953	biolink:BiologicalProcess	sexual reproduction	A type of reproduction that combines the genetic material of two gametes (such as a sperm or egg cell or fungal spores). The gametes have an haploid genome (with a single set of chromosomes, the product of a meiotic division) and combines with one another to produce a zygote (diploid).	Wikipedia:Sexual_reproduction	hp.json		http://purl.obolibrary.org/obo/GO_0019953		
HP:0002408	biolink:PhenotypicFeature	Cerebral arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the brain.	SNOMEDCT_US:234142008|Fyler:2201|UMLS:C0917804|MSH:D002538	hp.json	Cerebral AV malformation	http://purl.obolibrary.org/obo/HP_0002408		
HP:0002406	biolink:PhenotypicFeature	Limb dysmetria	A type of dysmetria involving the limbs.	UMLS:C4280577|UMLS:C1854489	hp.json	Uncoordinated limb movement	http://purl.obolibrary.org/obo/HP_0002406		
HP:0002403	biolink:PhenotypicFeature	Positive Romberg sign	The patient stands with the feet placed together and balance and is asked to close his or her eyes. A loss of balance upon eye closure is a positive Romberg sign and is interpreted as indicating a deficit in proprioception.	UMLS:C0240914|SNOMEDCT_US:298310004	hp.json		http://purl.obolibrary.org/obo/HP_0002403		
HP:0002404	biolink:PhenotypicFeature	Thickened superior cerebellar peduncle	Increased width of the superior cerebellar peduncle.	UMLS:C4021756	hp.json	Thick cerebellar peduncles	http://purl.obolibrary.org/obo/HP_0002404		
HP:0002401	biolink:PhenotypicFeature	Stroke-like episode	No consensus exists on what a stroke-like episode is, but these episodes can be functionally defined as a new neurological deficit, occurring with or without the context of seizures, which last longer than 24 hours.	UMLS:C1857287	hp.json	Stroke-like episodes|Strokelike episodes	http://purl.obolibrary.org/obo/HP_0002401		
GO:0150079	biolink:BiologicalProcess	negative regulation of neuroinflammatory response	Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.		hp.json		http://purl.obolibrary.org/obo/GO_0150079		
GO:0150078	biolink:BiologicalProcess	positive regulation of neuroinflammatory response	Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.		hp.json		http://purl.obolibrary.org/obo/GO_0150078		
GO:0150077	biolink:BiologicalProcess	regulation of neuroinflammatory response	Any process that modulates the frequency, rate or extent of neuroinflammatory response.		hp.json		http://purl.obolibrary.org/obo/GO_0150077		
PATO:0002468	biolink:NamedThing	distensible			hp.json		http://purl.obolibrary.org/obo/PATO_0002468		
GO:0150076	biolink:BiologicalProcess	neuroinflammatory response	The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents.		hp.json	nerve tissue inflammatory response|neural tissue inflammatory response|nervous tissue inflammatory response	http://purl.obolibrary.org/obo/GO_0150076		
UBERON:0006762	biolink:AnatomicalEntity	suspensory ligament of lens	The zonule of Zinn (Zinn's membrane, ciliary zonule) is a ring of fibrous strands connecting the ciliary body with the crystalline lens of the eye. The zonule of Zinn is split into two layers: a thin layer, which lines the hyaloid fossa, and a thicker layer, which is a collection of zonular fibers. Together, the fibers are known as the suspensory ligament of the lens[WP]. Modified or toughened vitreous that suspend the lens at the equator to the non-pigmented epithelium of the ciliary zone. In zebrafish, dorsal zonules are thickened as compared to ventral zonules. In both dorsal and ventral regions, these fibers delimit the vitreous body aqueous humor boundary[ZFA].	ZFA:0005573|FMA:58838	hp.json	zonula ciliaris|zonular fiber|ciliary zonule|zonules|zonule of Zinn|zonule|Zinn's membrane|zonula|suspensory ligament of the lens|ciliary zonule|zonula ciliaris	http://purl.obolibrary.org/obo/UBERON_0006762		pheno_slim|human_reference_atlas|vertebrate_core
HP:0002454	biolink:PhenotypicFeature	Eye of the tiger anomaly of globus pallidus	The presence, on T2-weighted magnetic resonance imaging, of markedly low signal intensity of the globus pallidus that surrounds a central region of high signal intensity in the anteromedial globus pallidus, producing an eye-of-the-tiger appearance. The sign is thought to represent iron accumulation in the globus pallidus.	UMLS:C4025705	hp.json		http://purl.obolibrary.org/obo/HP_0002454		
UBERON:0006761	biolink:AnatomicalEntity	corneo-scleral junction	The edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm.	MESH:D016850|ZFA:0005570|SCTID:63716004|GAID:896|FMA:58342|EMAPA:37835|EFO:0001403|Wikipedia:Corneal_limbus	hp.json	limbus corneae|corneal-scleral limbus|limbus corneae|sclerocorneal junction|corneoscleral junction|limbus corneae|sclerocorneal limbus|corneal-scleral limbus|corneal limbus|cornea limbus|limbus corneae|corneal limbus	http://purl.obolibrary.org/obo/UBERON_0006761		pheno_slim|efo_slim|vertebrate_core
UBERON:0004100	biolink:AnatomicalEntity	renal collecting system	The collecting duct system of the kidney consists of a series of tubules and ducts that connect the nephrons to the ureter. It participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and antidiuretic hormone.	FMA:265239	hp.json	collecting duct system|kidney collecting duct system|tubulus renalis colligens	http://purl.obolibrary.org/obo/UBERON_0004100		pheno_slim|human_reference_atlas
PATO:0002462	biolink:NamedThing	collagenous	A composition quality inhering in an bearer by virtue of the bearer's consisting of collagen.		hp.json		http://purl.obolibrary.org/obo/PATO_0002462		value_slim
HP:0002453	biolink:PhenotypicFeature	Abnormal globus pallidus morphology	An abnormality of the globus pallidus.	UMLS:C4025706	hp.json		http://purl.obolibrary.org/obo/HP_0002453		
HP:0002459	biolink:PhenotypicFeature	obsolete Dysautonomia			hp.json		http://purl.obolibrary.org/obo/HP_0002459		
HP:0002457	biolink:PhenotypicFeature	Abnormal head movements		SNOMEDCT_US:271799000|UMLS:C0476217	hp.json	Abnormal head movements	http://purl.obolibrary.org/obo/HP_0002457		
UBERON:0004108	biolink:AnatomicalEntity	clivus of occipital bone	Part of the cranium, the clivus is a shallow depression behind the dorsum sellC& that slopes obliquely backward. It forms a gradual sloping process at the anterior most portion of the basilar occipital bone at its junction with the sphenoid bone. On axial planes, it sits just posterior to the sphenoid sinuses. Just lateral to the clivus bilaterally is the foramen lacerum which contains the internal carotid artery, proximal to its anastamosis with the Circle of Willis. Posterior to the clivus is the basilar artery. The clivus supports the upper part of the pons.	FMA:75747|UMLS:C0222724|NCIT:C12494	hp.json	clivus ossis occipitalis|Wackenheim's clivus line|occipital bone clivus|clivus	http://purl.obolibrary.org/obo/UBERON_0004108		pheno_slim
UBERON:0004105	biolink:AnatomicalEntity	subungual region	Region beneath a nail or claw.	CALOHA:TS-2351	hp.json		http://purl.obolibrary.org/obo/UBERON_0004105		pheno_slim
UBERON:0006767	biolink:AnatomicalEntity	head of femur	The hemispheric articular surface at the upper extremity of the thigh bone[Stedman, 26th ed]. The femur head is the highest part of the thigh bone. It is supported by the neck of the femur. The head is globular and forms rather more than a hemisphere, is directed upward, medialward, and a little forward, the greater part of its convexity being above and in front. Its surface is smooth, coated with cartilage in the fresh state, except over an ovoid depression, the fovea capitis femoris, which is situated a little below and behind the center of the head, and gives attachment to the ligament of head of femur. If there is a fracture of the neck of the femur, the blood supply through the ligament becomes crucial. In orthopedic surgery, the head of the femur is important because it can undergo avascular necrosis and consequent osteochondritis dissecans. The head is removed in total hip replacement surgery [WP].	AAO:0000892|NCIT:C32718|FMA:32851|EMAPA:37541|MA:0003050|UMLS:C0015813|MESH:D005270|galen:FemoralHead	hp.json	femur head|caput femoris|kopf des Schenkelbeins|caput femoris|capital femoral epiphysis|acetabular head|femoral head	http://purl.obolibrary.org/obo/UBERON_0006767		pheno_slim
UBERON:0004106	biolink:AnatomicalEntity	crus of ear	Horizontal piece of cartilage located outside the ear canal that divides the upper and lower parts of the ear.	NCIT:C32410|FMA:61024|UMLS:C0229319	hp.json	crus of helix|crus helicis|crus of helical part of auricular cartilage	http://purl.obolibrary.org/obo/UBERON_0004106		pheno_slim
UBERON:0004103	biolink:AnatomicalEntity	alveolar ridge	One of the two jaw ridges either on the roof of the mouth between the upper teeth and the hard palate or on the bottom of the mouth behind the lower teeth[WP]. The alveolar ridges contain the sockets (alveoli) of the teeth[HP].	EMAPA:35118|FMA:313923|NCIT:C89749|MESH:D000539|GAID:215|BTO:0001383|MA:0003119|UMLS:C0447411	hp.json	alveolar process|alveolar bone|alveolar margin|alveolar body|margo alveolaris	http://purl.obolibrary.org/obo/UBERON_0004103		pheno_slim
HP:0002450	biolink:PhenotypicFeature	Abnormal motor neuron morphology	Any structural anomaly that affects the motor neuron.	UMLS:C4025707	hp.json	Abnormal shape of motor neuron	http://purl.obolibrary.org/obo/HP_0002450		
HP:0002451	biolink:PhenotypicFeature	Limb dystonia	A type of dystonia (abnormally increased muscular tone causing fixed abnormal postures) that affects muscles of the limbs.	UMLS:C0751093|MSH:D004421	hp.json		http://purl.obolibrary.org/obo/HP_0002451		
UBERON:0004104	biolink:AnatomicalEntity	hairline	Anatomical line demarcating the boundary between forehead and scalp.	FMA:285412	hp.json		http://purl.obolibrary.org/obo/UBERON_0004104		pheno_slim
UBERON:0004101	biolink:AnatomicalEntity	nasolabial region			hp.json		http://purl.obolibrary.org/obo/UBERON_0004101		pheno_slim
UBERON:0006763	biolink:AnatomicalEntity	epithelium of conjunctiva	Layer of nonkeratinized squamous epithelium lining the conjunctiva, overlying scleral tissue.	FMA:62131|UMLS:C1179037|EFO:0001916|BTO:0005131|NCIT:C32365	hp.json	conjunctiva epithelium|conjunctival epithelium	http://purl.obolibrary.org/obo/UBERON_0006763		pheno_slim|efo_slim
PATO:0002478	biolink:NamedThing	transversely striated	A shape quality inhering in a bearer by virtue of the bearer's being marked by narrow lines or grooves, usually parallel, that are oriented transversely relative to the long axis of the bearer.		hp.json		http://purl.obolibrary.org/obo/PATO_0002478		cell_quality|value_slim|mpath_slim
HP:0002465	biolink:PhenotypicFeature	Poor speech		UMLS:C1848207|UMLS:C4280574	hp.json	Problems speaking|Difficulty speaking|Poor speech	http://purl.obolibrary.org/obo/HP_0002465		
HP:0002463	biolink:PhenotypicFeature	Language impairment	Language impairment is a deficit in comprehension or production of language that includes reduced vocabulary, limited sentence structure or impairments in written or spoken communication. Language abilities are substantially and quantifiably below age expectations.	SNOMEDCT_US:62305002|UMLS:C0023015|MSH:D007806	hp.json	Language impairment|Language disorder	http://purl.obolibrary.org/obo/HP_0002463		
HP:0002464	biolink:PhenotypicFeature	Spastic dysarthria	A type of dysarthria related to bilateral damage of the upper motor neuron tracts of the pyramidal and extra- pyramidal tracts. Speech of affected individuals is slow, effortful, and has a harsh vocal quality.	MSH:D004401|SNOMEDCT_US:229684006|UMLS:C0454596	hp.json	Rigid dysarthria	http://purl.obolibrary.org/obo/HP_0002464		
UBERON:0006757	biolink:AnatomicalEntity	lateral lingual swelling	During the third week there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings (or distal tongue bud) which rise from the inner surface of the mandibular arch and meet in the middle line.	EMAPA:17189|FMA:313628|VHOG:0000731|Wikipedia:Lateral_lingual_swelling|EHDAA2:0000911	hp.json	lateral lingual prominence|tuberculum laterale|lateral swellings|tuberculum laterale|lateral swellings|tuberculum linguale laterale|tuberculum linguale laterale	http://purl.obolibrary.org/obo/UBERON_0006757		
UBERON:0006756	biolink:AnatomicalEntity	median lingual swelling	During the third week of embryological development there appears, immediately behind the ventral ends of the two halves of the mandibular arch, a rounded swelling named the tuberculum impar, which was described by His as undergoing enlargement to form the buccal part of the tongue. More recent researches, however, show that this part of the tongue is mainly, if not entirely, developed from a pair of lateral swellings which rise from the inner surface of the mandibular arch and meet in the middle line. The site of their meeting remains post-embryonically as the median sulcus of the tongue. The tuberculum impar is said to form the central part of the tongue immediately in front of the foramen cecum, but Hammar insists that it is purely a transitory structure and forms no part of the adult tongue[WP, Gray's].	EMAPA:17187|Wikipedia:Tuberculum_impar|VHOG:0000730|FMA:312476|EHDAA2:0001081|SCTID:308821003	hp.json	median tongue bud|tuberculum linguale mediale|tuberculum linguale mediale|tuberculum impar|median lingual swelling|median tongue bud	http://purl.obolibrary.org/obo/UBERON_0006756		
HP:0002461	biolink:PhenotypicFeature	Dense calcifications in the cerebellar dentate nucleus		UMLS:C1859273	hp.json		http://purl.obolibrary.org/obo/HP_0002461		
HP:0002460	biolink:PhenotypicFeature	Distal muscle weakness	Reduced strength of the musculature of the distal extremities.	UMLS:C1864696|SNOMEDCT_US:249942005|UMLS:C0427065	hp.json	Distal limb muscle weakness|Distal limb weakness|Weakness of distal muscles|Distal paresis|Muscle weakness, distal limbs, due to neuronopathy|Muscle weakness, distal|Weakness of outermost muscles|Distal limb muscle weakness due to peripheral neuropathy|Distal muscular weakness	http://purl.obolibrary.org/obo/HP_0002460		
HP:0002438	biolink:PhenotypicFeature	Cerebellar malformation		UMLS:C4025708	hp.json		http://purl.obolibrary.org/obo/HP_0002438		
HP:0002439	biolink:PhenotypicFeature	Frontolimbic dementia		UMLS:C1836151	hp.json		http://purl.obolibrary.org/obo/HP_0002439		
GO:0150052	biolink:BiologicalProcess	regulation of postsynapse assembly	Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse.		hp.json		http://purl.obolibrary.org/obo/GO_0150052		goslim_synapse
HP:0002436	biolink:PhenotypicFeature	Occipital meningocele	A herniation of meninges through a congenital bone defect in the skull in the occipital region.	UMLS:C1848652|SNOMEDCT_US:445468002	hp.json		http://purl.obolibrary.org/obo/HP_0002436		
HP:0002435	biolink:PhenotypicFeature	Meningocele	Protrusion of the meninges through a defect of the skull or vertebral column.	SNOMEDCT_US:171131006|MSH:D008588|UMLS:C0025299	hp.json		http://purl.obolibrary.org/obo/HP_0002435		
UBERON:0006742	biolink:AnatomicalEntity	canthus	A canthus is a corner of the eye where the upper and lower eyelids meet. The bicanthal plane is the transversal plane linking both canthi and defines the upper boundary of the midface.	EMAPA:37457|FMA:59222	hp.json	bicanthal plane|canthi|canthorum|canthus of eye|palpebral commissure|angle of eye|canthoplasty|canthus (anatomy)|bicanthal	http://purl.obolibrary.org/obo/UBERON_0006742		
NBO:0000929	biolink:NamedThing	frequency of drinking			hp.json		http://purl.obolibrary.org/obo/NBO_0000929		
GO:0150063	biolink:BiologicalProcess	visual system development	The process whose specific outcome is the progression of the visual system over time, from its formation to the mature structure, including the eye, parts of the central nervous system (CNS) involved in processing of visual inputs, and connecting nerve pathways.		hp.json	visual pathway development|optic pathway development	http://purl.obolibrary.org/obo/GO_0150063		
HP:0002444	biolink:PhenotypicFeature	Hypothalamic hamartoma	The presence of a hamartoma of the hypothalamus.	UMLS:C0342418|SNOMEDCT_US:237714006|MSH:C537158	hp.json		http://purl.obolibrary.org/obo/HP_0002444		
HP:0002442	biolink:PhenotypicFeature	Dyscalculia	A specific learning disability involving mathematics and arithmetic.	UMLS:C1411876|SNOMEDCT_US:47916000|UMLS:C4280576	hp.json	Difficulty making arithmetical calculations	http://purl.obolibrary.org/obo/HP_0002442		
HP:0002448	biolink:PhenotypicFeature	Progressive encephalopathy		UMLS:C4280575|UMLS:C1838578	hp.json	Progressive brain disease	http://purl.obolibrary.org/obo/HP_0002448		
HP:0002445	biolink:PhenotypicFeature	Tetraplegia	Paralysis of all four limbs, and trunk of the body below the level of an associated injury to the spinal cord. The etiology of quadriplegia is similar to that of paraplegia except that the lesion is in the cervical spinal cord rather than in the thoracic or lumbar segments of the spinal cord.	SNOMEDCT_US:11538006|MSH:D011782|UMLS:C0034372	hp.json	Quadriplegia|Paralysis of all four limbs	http://purl.obolibrary.org/obo/HP_0002445		
HP:0002446	biolink:PhenotypicFeature	Astrocytosis	Proliferation of astrocytes in the area of a lesion of the central nervous system.	MSH:D005911|SNOMEDCT_US:81415000|UMLS:C3887640	hp.json	Increase in astrocyte number	http://purl.obolibrary.org/obo/HP_0002446		
UBERON:0018707	biolink:AnatomicalEntity	bladder organ	A membranous sac in animals that serves as the receptacle of a liquid or contains gas.	BTO:0000123	hp.json	bladder	http://purl.obolibrary.org/obo/UBERON_0018707		
CHEBI:57977	biolink:ChemicalSubstance	bilirubin(2-)	A dicarboxylic acid dianion obtained by deprotonation of the two carboxy groups of bilirubin; major species at pH 7.3.	Beilstein:4083310	hp.json	bilirubin IXalpha|2,7,13,17-tetramethyl-1,19-dioxo-3,18-divinyl-1,10,19,22,23,24-hexahydro-21H-biline-8,12-dipropanoate|bilirubin dianion	http://purl.obolibrary.org/obo/CHEBI_57977		3_STAR
GO:0042480	biolink:BiologicalProcess	negative regulation of eye photoreceptor cell development	Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development.		hp.json	downregulation of eye photoreceptor cell development|down regulation of eye photoreceptor cell development|inhibition of eye photoreceptor cell development|negative regulation of eye photoreceptor development|down-regulation of eye photoreceptor cell development	http://purl.obolibrary.org/obo/GO_0042480		
GO:0042488	biolink:BiologicalProcess	positive regulation of odontogenesis of dentin-containing tooth	Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.		hp.json	activation of odontogenesis|positive regulation of odontogenesis of dentine-containing tooth|stimulation of odontogenesis|up-regulation of odontogenesis|up regulation of odontogenesis|positive regulation of odontogenesis of dentine-containing teeth|upregulation of odontogenesis	http://purl.obolibrary.org/obo/GO_0042488		
GO:0042487	biolink:BiologicalProcess	regulation of odontogenesis of dentin-containing tooth	Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.		hp.json	regulation of odontogenesis of dentine-containing teeth|regulation of odontogenesis of dentine-containing tooth	http://purl.obolibrary.org/obo/GO_0042487		
GO:0042482	biolink:BiologicalProcess	positive regulation of odontogenesis	Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth.		hp.json	stimulation of odontogenesis|upregulation of odontogenesis|positive regulation of tooth development|up-regulation of odontogenesis|positive regulation of odontogenesis of calcareous or chitinous tooth|up regulation of odontogenesis|activation of odontogenesis	http://purl.obolibrary.org/obo/GO_0042482		
GO:0042481	biolink:BiologicalProcess	regulation of odontogenesis	Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.		hp.json	regulation of odontogenesis of calcareous or chitinous tooth|regulation of tooth development	http://purl.obolibrary.org/obo/GO_0042481		
GO:0042483	biolink:BiologicalProcess	negative regulation of odontogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth.		hp.json	down-regulation of odontogenesis|down regulation of odontogenesis|negative regulation of odontogenesis of calcareous or chitinous tooth|negative regulation of tooth development|inhibition of odontogenesis|downregulation of odontogenesis	http://purl.obolibrary.org/obo/GO_0042483		
GO:0042489	biolink:BiologicalProcess	negative regulation of odontogenesis of dentin-containing tooth	Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx.		hp.json	negative regulation of odontogenesis of dentine-containing teeth|down regulation of odontogenesis|negative regulation of odontogenesis of dentine-containing tooth|downregulation of odontogenesis|inhibition of odontogenesis|down-regulation of odontogenesis|negative regulation of odontogenesis	http://purl.obolibrary.org/obo/GO_0042489		
GO:0030485	biolink:CellularComponent	smooth muscle contractile fiber	The contractile fiber of smooth muscle cells.		hp.json		http://purl.obolibrary.org/obo/GO_0030485		
BSPO:0000099	biolink:NamedThing	posterior_to	x posterior to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that extends through an organism from head end to opposite end of body or tail.	BSPO:0000099	hp.json	caudal_to	http://purl.obolibrary.org/obo/BSPO_0000099		
BSPO:0000098	biolink:NamedThing	dorsal_to	x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).	BSPO:0000098	hp.json		http://purl.obolibrary.org/obo/BSPO_0000098		
PATO:0000261	biolink:NamedThing	maturity	A quality of a single physical entity which is held by a bearer when the latter exhibits a state of growth, differentiation, or development.		hp.json		http://purl.obolibrary.org/obo/PATO_0000261		attribute_slim
GO:0030473	biolink:BiologicalProcess	nuclear migration along microtubule	The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.		hp.json	transport of nucleus, microtubule-mediated|microtubule-mediated nuclear migration|microtubule-dependent nucleus positioning|microtubule cytoskeleton-dependent nuclear positioning|nuclear movement, microtubule-mediated|transport of nucleus by microtubules|microtubule cytoskeleton-dependent nucleus positioning|nucleus migration|nuclear migration, microtubule-mediated|microtubule-dependent nuclear positioning	http://purl.obolibrary.org/obo/GO_0030473		
BSPO:0000097	biolink:NamedThing	distal_to	x distal to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal).	BSPO:0000097	hp.json		http://purl.obolibrary.org/obo/BSPO_0000097		
BSPO:0000096	biolink:NamedThing	anterior_to	x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer	BSPO:0000096	hp.json		http://purl.obolibrary.org/obo/BSPO_0000096		
PATO:0000274	biolink:NamedThing	fertility	A reproductive quality inhering in a bearer by virtue of the bearer's initiating, sustaining, or supporting reproduction.		hp.json		http://purl.obolibrary.org/obo/PATO_0000274		disposition_slim|attribute_slim
RO:0002490	biolink:NamedThing	existence overlaps	x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))		hp.json		http://purl.obolibrary.org/obo/RO_0002490		
RO:0002495	biolink:NamedThing	immediate transformation of	x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t	RO:0002495	hp.json	direct_transformation_of|immediately transforms from	http://purl.obolibrary.org/obo/RO_0002495		
RO:0002496	biolink:NamedThing	existence starts during or after	x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y).	RO:0002496	hp.json		http://purl.obolibrary.org/obo/RO_0002496		
RO:0002497	biolink:NamedThing	existence ends during or before	x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends.	RO:0002497	hp.json		http://purl.obolibrary.org/obo/RO_0002497		
GO:0005496	biolink:MolecularActivity	steroid binding	Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.		hp.json		http://purl.obolibrary.org/obo/GO_0005496		goslim_pir
RO:0002491	biolink:NamedThing	existence starts and ends during	x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)	RO:0002491	hp.json	exists during	http://purl.obolibrary.org/obo/RO_0002491		
RO:0002492	biolink:NamedThing	existence ends during	Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely.	RO:0002492	hp.json	ceases_to_exist_during	http://purl.obolibrary.org/obo/RO_0002492		
RO:0002493	biolink:NamedThing	existence ends with	Relation between continuant and occurrent, such that c ceases to exist at the end of p.	RO:0002493	hp.json		http://purl.obolibrary.org/obo/RO_0002493		
RO:0002494	biolink:NamedThing	transformation of	x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships	RO:0002494	hp.json	transforms from	http://purl.obolibrary.org/obo/RO_0002494		
RO:0002488	biolink:NamedThing	existence starts during	Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s.	RO:0002488	hp.json	begins_to_exist_during	http://purl.obolibrary.org/obo/RO_0002488		
RO:0002489	biolink:NamedThing	existence starts with	x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y).	RO:0002489	hp.json		http://purl.obolibrary.org/obo/RO_0002489		
GO:0030449	biolink:BiologicalProcess	regulation of complement activation	Any process that modulates the frequency, rate or extent of complement activation.		hp.json	regulation of complement cascade	http://purl.obolibrary.org/obo/GO_0030449		
HP:0004804	biolink:PhenotypicFeature	Congenital hemolytic anemia	A form of hemolytic anemia with congenital onset.	UMLS:C0002881|SNOMEDCT_US:42601008|MSH:D000745|UMLS:C4020827|SNOMEDCT_US:38911009	hp.json	Congenital hemolytic anaemia|Neonatal hemolytic anaemia|Congenital haemolytic anaemia|Neonatal hemolytic anemia|Congenital haemolytic anemia	http://purl.obolibrary.org/obo/HP_0004804		
RO:0002487	biolink:NamedThing	relation between physical entity and a process or stage			hp.json		http://purl.obolibrary.org/obo/RO_0002487		
HP:0004809	biolink:PhenotypicFeature	Neonatal alloimmune thrombocytopenia	Low platelet count associated with maternal platelet-specific alloantibodies.	MSH:D054098|SNOMEDCT_US:240305000|UMLS:C3853779	hp.json		http://purl.obolibrary.org/obo/HP_0004809		
RO:0002481	biolink:NamedThing	is kinase activity			hp.json		http://purl.obolibrary.org/obo/RO_0002481		
HP:0004808	biolink:PhenotypicFeature	Acute myeloid leukemia	A form of leukemia characterized by overproduction of an early myeloid cell.	SNOMEDCT_US:17788007|UMLS:C0023467|SNOMEDCT_US:413443009|MSH:D015470|SNOMEDCT_US:91861009	hp.json	Acute myeloid leukaemia|Acute myeloblastic leukemia|Acute myelocytic leukaemia|AML|Acute myelocytic leukemia|Acute myeloblastic leukaemia|Acute myelogenous leukemia|Acute myelogenous leukaemia	http://purl.obolibrary.org/obo/HP_0004808		
HP:0004802	biolink:PhenotypicFeature	Episodic hemolytic anemia	A form of hemolytic anemia that occurs in repeated episodes.	UMLS:C1859495	hp.json	Episodic hemolytic anaemia|Episodic hemolysis	http://purl.obolibrary.org/obo/HP_0004802		
RO:0002479	biolink:NamedThing	has part that occurs in	p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c.		hp.json		http://purl.obolibrary.org/obo/RO_0002479		ro-eco
HP:0004800	biolink:PhenotypicFeature	Duodenal diverticula		SNOMEDCT_US:197083003|UMLS:C0341266	hp.json		http://purl.obolibrary.org/obo/HP_0004800		
RO:0002473	biolink:NamedThing	composed primarily of	x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y.	RO:0002473	hp.json		http://purl.obolibrary.org/obo/RO_0002473		ro-eco
GO:0030431	biolink:BiologicalProcess	sleep	Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.	Wikipedia:Sleep	hp.json	diapause|dormancy|lethargus	http://purl.obolibrary.org/obo/GO_0030431		goslim_pir
GO:0030432	biolink:BiologicalProcess	peristalsis	A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.	Wikipedia:Peristalsis	hp.json		http://purl.obolibrary.org/obo/GO_0030432		
GO:0030424	biolink:CellularComponent	axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.	Wikipedia:Axon|NIF_Subcellular:sao1770195789	hp.json		http://purl.obolibrary.org/obo/GO_0030424		
GO:0030425	biolink:CellularComponent	dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.	NIF_Subcellular:sao1211023249|Wikipedia:Dendrite	hp.json		http://purl.obolibrary.org/obo/GO_0030425		
GO:0005488	biolink:MolecularActivity	binding	The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.	Wikipedia:Binding_(molecular)	hp.json	ligand	http://purl.obolibrary.org/obo/GO_0005488		gocheck_do_not_annotate|goslim_pir|goslim_plant
RO:0002464	biolink:NamedThing	helper property (not for use in curation)			hp.json		http://purl.obolibrary.org/obo/RO_0002464		
GO:0030421	biolink:BiologicalProcess	defecation	The expulsion of feces from the rectum.	Wikipedia:Defecation	hp.json		http://purl.obolibrary.org/obo/GO_0030421		
HP:0100644	biolink:PhenotypicFeature	Melanonychia	Brown or black discoloration of the nails.	UMLS:C1142305|SNOMEDCT_US:402633003|MEDDRA:10058330	hp.json		http://purl.obolibrary.org/obo/HP_0100644		
HP:0100645	biolink:PhenotypicFeature	Cystocele	Anterior vaginal wall prolapse with bulging of the bladder into the vagina.	ICD-9:618.00|SNOMEDCT_US:252005008|UMLS:C1394494	hp.json	Bladder hernia|Bladder prolapse|Dropped bladder|Prolapsed bladder	http://purl.obolibrary.org/obo/HP_0100645		
HP:0100642	biolink:PhenotypicFeature	Neoplasm of the adrenal medulla	The presence of a neoplasm of the adrenal medulla.	NCIT:C3262|UMLS:C0596046|SNOMEDCT_US:127023007	hp.json	Medullar adrenal neoplasia	http://purl.obolibrary.org/obo/HP_0100642		
HP:0100643	biolink:PhenotypicFeature	Abnormality of nail color	An anomaly of the color of the nail.	UMLS:C4020960	hp.json	Nail dyschromia|Abnormality of nail color|Abnormality of nail colour	http://purl.obolibrary.org/obo/HP_0100643		
HP:0100640	biolink:PhenotypicFeature	Laryngeal cyst	Presence of a cyst (sac-like structure) located in the larynx.	UMLS:C0339880|SNOMEDCT_US:195867000	hp.json		http://purl.obolibrary.org/obo/HP_0100640		
HP:0100641	biolink:PhenotypicFeature	Neoplasm of the adrenal cortex	The presence of a neoplasm of the adrenal cortex.	SNOMEDCT_US:127022002|SNOMEDCT_US:18365006|MSH:D000306|NCIT:C3262|UMLS:C0001618	hp.json	Cortical adrenal neoplasia	http://purl.obolibrary.org/obo/HP_0100641		
CHEBI:33913	biolink:ChemicalSubstance	corrinoid	A derivative of the corrin nucleus, which contains four reduced or partly reduced pyrrole rings joined in a macrocycle by three =C- groups and one direct carbon-carbon bond linking alpha positions.	KEGG:C06021	hp.json	Corrinoid protein|Corrinoid protein Co+|Korrinoid|corrinoid|corrinoide|corrinoids|corrinoides|Corrinoid	http://purl.obolibrary.org/obo/CHEBI_33913		3_STAR
CHEBI:33916	biolink:ChemicalSubstance	aldopentose	A pentose with a (potential) aldehyde group at one end.	PMID:10723607	hp.json	aldopentose|aldopentoses	http://purl.obolibrary.org/obo/CHEBI_33916		3_STAR
CHEBI:33917	biolink:ChemicalSubstance	aldohexose	A hexose with a (potential) aldehyde group at one end.		hp.json	aldohexose|aldohexoses	http://purl.obolibrary.org/obo/CHEBI_33917		3_STAR
RO:0002450	biolink:NamedThing	directly positively regulates activity of	The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B.  For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B.		hp.json	molecularly increases activity of	http://purl.obolibrary.org/obo/RO_0002450		
RO:0002448	biolink:NamedThing	directly regulates activity of	The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B.  A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B.		hp.json	molecularly controls	http://purl.obolibrary.org/obo/RO_0002448		
RO:0002449	biolink:NamedThing	directly negatively regulates activity of	The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B.  For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B.		hp.json	molecularly decreases activity of	http://purl.obolibrary.org/obo/RO_0002449		
GO:0042401	biolink:BiologicalProcess	cellular biogenic amine biosynthetic process	The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.		hp.json	biogenic amine synthesis|biogenic amine formation|biogenic amine biosynthesis|biogenic amine anabolism	http://purl.obolibrary.org/obo/GO_0042401		
RO:0002447	biolink:NamedThing	phosphorylates			hp.json		http://purl.obolibrary.org/obo/RO_0002447		
GO:0042403	biolink:NamedThing	thyroid hormone metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0042403		
HP:0100648	biolink:PhenotypicFeature	Neoplasm of the tongue	A tumor (abnormal growth of tissue) of the tongue.	MSH:D014062|NCIT:C3262|UMLS:C0040411|SNOMEDCT_US:126778001	hp.json		http://purl.obolibrary.org/obo/HP_0100648		
HP:0100649	biolink:PhenotypicFeature	Neoplasm of the oral cavity	A tumor (abnormal growth of tissue) of the oral cavity.	SNOMEDCT_US:235075007|UMLS:C0026640|UMLS:C4280289|NCIT:C3262|SNOMEDCT_US:1071000119107|MSH:D009062|SNOMEDCT_US:126797001|UMLS:C0149744	hp.json	Neoplasm of the mouth|Tumour of oral cavity|Mouth neoplasm|Lesion of oral cavity|Tumor of oral cavity|Mouth tumor	http://purl.obolibrary.org/obo/HP_0100649		
HP:0100646	biolink:PhenotypicFeature	Thyroiditis	Inflammation of the thyroid gland.	MSH:D013966|UMLS:C0040147|SNOMEDCT_US:82119001	hp.json	Thyroid gland inflammation	http://purl.obolibrary.org/obo/HP_0100646		
HP:0100647	biolink:PhenotypicFeature	Graves disease	An autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones (a serious metabolic imbalance known as hyperthyroidism and thyrotoxicosis). This is caused by autoantibodies to the TSH-receptor (TSHR-Ab) that activate that TSH-receptor (TSHR), thereby stimulating thyroid hormone synthesis and secretion, and thyroid growth (causing a diffusely enlarged goiter). The resulting state of hyperthyroidism can cause a dramatic constellation of neuropsychological and physical signs and symptoms, which can severely compromise the patients.	UMLS:C0018213|SNOMEDCT_US:353295004|SNOMEDCT_US:55807009|MSH:D006111	hp.json	Morbus Basedow	http://purl.obolibrary.org/obo/HP_0100647		
HP:0100656	biolink:PhenotypicFeature	Thoracoabdominal wall defect	Failure to close of the chest and abdominal wall likely caused by the failure of the ventral wall to close during week 4 of development.	UMLS:C4022002	hp.json	Thoracoabdominal schisis	http://purl.obolibrary.org/obo/HP_0100656		
HP:0100653	biolink:PhenotypicFeature	Optic neuritis	Inflammation of the optic nerve.	MSH:D009902|SNOMEDCT_US:66760008|UMLS:C0029134	hp.json		http://purl.obolibrary.org/obo/HP_0100653		
UBERON:0018376	biolink:AnatomicalEntity	molar tooth 1	The molar tooth of the upper or lower jaw that is phylogenetically number 1.	FMA:321614	hp.json	first molar tooth|m1|molar 1|molar 1 tooth	http://purl.obolibrary.org/obo/UBERON_0018376		
HP:0100654	biolink:PhenotypicFeature	Retrobulbar optic neuritis	Optic neuritis that occurs in the section of the optic nerve located behind the eyeball.	MSH:D009902|UMLS:C0085582|SNOMEDCT_US:230507009	hp.json	Retrobulbar neuritis	http://purl.obolibrary.org/obo/HP_0100654		
HP:0100651	biolink:PhenotypicFeature	Type I diabetes mellitus	A chronic condition in which the pancreas produces little or no insulin. Type I diabetes mellitus is manifested by the sudden onset of severe hyperglycemia with rapid progression to diabetic ketoacidosis unless treated with insulin.	UMLS:C0011854|SNOMEDCT_US:46635009|MSH:D003922	hp.json	Type 1 diabetes|Juvenile diabetes mellitus|Type I diabetes|Insulin-dependent diabetes mellitus|Diabetes mellitus Type I	http://purl.obolibrary.org/obo/HP_0100651		
HP:0100650	biolink:PhenotypicFeature	Vaginal neoplasm	A tumor (abnormal growth of tissue) of the vagina.	UMLS:C0750081|UMLS:C0042258|SNOMEDCT_US:126921000|NCIT:C3262|MSH:D014625	hp.json	Vaginal neoplasia|Vaginal tumor|Vaginal tumour	http://purl.obolibrary.org/obo/HP_0100650		
GO:0042417	biolink:BiologicalProcess	dopamine metabolic process	The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.		hp.json	dopamine metabolism	http://purl.obolibrary.org/obo/GO_0042417		
GO:0042416	biolink:BiologicalProcess	dopamine biosynthetic process	The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.		hp.json	dopamine anabolism|dopamine synthesis|dopamine formation|dopamine biosynthesis	http://purl.obolibrary.org/obo/GO_0042416		
RO:0002433	biolink:NamedThing	contributes to morphology of	p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm.	RO:0002433	hp.json		http://purl.obolibrary.org/obo/RO_0002433		
RO:0002434	biolink:NamedThing	interacts with	A relationship that holds between two entities in which the processes executed by the two entities are causally connected.		hp.json	in pairwise interaction with	http://purl.obolibrary.org/obo/RO_0002434		ro-eco
GO:0042415	biolink:BiologicalProcess	norepinephrine metabolic process	The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.		hp.json	noradrenaline metabolism|noradrenaline metabolic process|levarterenol metabolism|norepinephrine metabolism|levarterenol metabolic process	http://purl.obolibrary.org/obo/GO_0042415		
RO:0002436	biolink:NamedThing	molecularly interacts with	An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other.		hp.json		http://purl.obolibrary.org/obo/RO_0002436		
HP:0100659	biolink:PhenotypicFeature	Abnormal cerebral vascular morphology	An anomaly of the cerebral blood vessels.	UMLS:C4022001	hp.json	Abnormality of the cerebral vasculature|Abnormality of the cerebral blood vessels	http://purl.obolibrary.org/obo/HP_0100659		
HP:0100657	biolink:PhenotypicFeature	Thoracoabdominal eventration	Congenital protrusion of the abdominal or thoracic viscera, usually with a defect of the sternum and ribs as well as of the abdominal walls.	SNOMEDCT_US:44518003|UMLS:C0266682	hp.json	Celosomia|Kelosomia	http://purl.obolibrary.org/obo/HP_0100657		
HP:0100658	biolink:PhenotypicFeature	Cellulitis	A bacterial infection and inflammation of the skin und subcutaneous tissues.	UMLS:C0007642|SNOMEDCT_US:385627004|MSH:D017192|SNOMEDCT_US:128936008|MSH:D002481|SNOMEDCT_US:128045006|UMLS:C0162627	hp.json	Skin infection|Skin infections|Bacterial infection of skin	http://purl.obolibrary.org/obo/HP_0100658		hposlim_core
HP:0100665	biolink:PhenotypicFeature	Angioedema	Rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues of the skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue during a period of minutes to several hours. The swelling can also occur elsewhere, typically in the hands. Angioedema is similar to urticaria, but the swelling is subcutaneous rather than on the epidermis.	SNOMEDCT_US:41291007|UMLS:C0002994|SNOMEDCT_US:400075008|MSH:D000799	hp.json	Quincke edema|Angiooedema|Angioneurotic oedema|Quincke oedema	http://purl.obolibrary.org/obo/HP_0100665		
HP:0100662	biolink:PhenotypicFeature	Chondritis	Inflammation of cartilage.	UMLS:C0008439|SNOMEDCT_US:46176001	hp.json	Cartilage inflammation	http://purl.obolibrary.org/obo/HP_0100662		
HP:0100663	biolink:PhenotypicFeature	Synotia	A congenital malformation characterized by the union or approximation of the ears in front of the neck, often accompanied by the absence or defective development of the lower jaw.	SNOMEDCT_US:77471004|UMLS:C0266677	hp.json		http://purl.obolibrary.org/obo/HP_0100663		
HP:0100660	biolink:PhenotypicFeature	Dyskinesia	A movement disorder which consists of effects including diminished voluntary movements and the presence of involuntary movements.	UMLS:C0013384|MSH:D020820|SNOMEDCT_US:9748009	hp.json	Disorder of involuntary muscle movements|Dyskinesis|Dyskinesias	http://purl.obolibrary.org/obo/HP_0100660		
HP:0100661	biolink:PhenotypicFeature	Trigeminal neuralgia	A neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve. One, two, or all three branches of the nerve may be affected.	MSH:D014277|SNOMEDCT_US:31681005|UMLS:C0040997	hp.json	Tic douloureux	http://purl.obolibrary.org/obo/HP_0100661		
RO:0002430	biolink:NamedThing	involved in negative regulation of	c involved in regulation of p if c is involved in some p' and p' negatively regulates some p		hp.json		http://purl.obolibrary.org/obo/RO_0002430		
RO:0002431	biolink:NamedThing	involved in or involved in regulation of	c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p		hp.json		http://purl.obolibrary.org/obo/RO_0002431		
RO:0002432	biolink:NamedThing	is active in	c executes activity in d if and only if c enables p and p occurs_in d.  Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.		hp.json	enables activity in	http://purl.obolibrary.org/obo/RO_0002432		
GO:0042421	biolink:BiologicalProcess	norepinephrine biosynthetic process	The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.		hp.json	levarterenol biosynthesis|levarterenol biosynthetic process|norepinephrine biosynthesis|norepinephrine anabolism|noradrenaline biosynthesis|noradrenaline biosynthetic process|norepinephrine synthesis|norepinephrine formation	http://purl.obolibrary.org/obo/GO_0042421		
GO:0042428	biolink:BiologicalProcess	serotonin metabolic process	The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.		hp.json	serotonin metabolism	http://purl.obolibrary.org/obo/GO_0042428		
RO:0002427	biolink:NamedThing	causally downstream of or within	inverse of causally upstream of or within	RO:0002427	hp.json		http://purl.obolibrary.org/obo/RO_0002427		http://purl.obolibrary.org/obo/RO_0002259
GO:0042427	biolink:BiologicalProcess	serotonin biosynthetic process	The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.	Wikipedia:Serotonin	hp.json	serotonin formation|serotonin biosynthesis|serotonin anabolism|serotonin synthesis	http://purl.obolibrary.org/obo/GO_0042427		
HP:0002199	biolink:PhenotypicFeature	Hypocalcemic seizures		UMLS:C1855841	hp.json	Seizures due to hypocalcemia|Low calcium seizures	http://purl.obolibrary.org/obo/HP_0002199		
RO:0002428	biolink:NamedThing	involved in regulation of	c involved in regulation of p if c is involved in some p' and p' regulates some p		hp.json		http://purl.obolibrary.org/obo/RO_0002428		
RO:0002429	biolink:NamedThing	involved in positive regulation of	c involved in regulation of p if c is involved in some p' and p' positively regulates some p		hp.json		http://purl.obolibrary.org/obo/RO_0002429		
GO:0042423	biolink:BiologicalProcess	catecholamine biosynthetic process	The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.	Wikipedia:Catecholamines	hp.json	catecholamine synthesis|catecholamine formation|catecholamine anabolism|catecholamine biosynthesis	http://purl.obolibrary.org/obo/GO_0042423		
HP:0002193	biolink:PhenotypicFeature	Pseudobulbar behavioral symptoms	Individuals with Pseudobulbar signs often also demonstrate abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc.	UMLS:C4025720	hp.json	Pseudobulbar behavioural symptoms	http://purl.obolibrary.org/obo/HP_0002193		
HP:0002194	biolink:PhenotypicFeature	Delayed gross motor development	A type of motor delay characterized by a delay in acquiring the ability to control the large muscles of the body for walking, running, sitting, and crawling.	UMLS:C1837658|SNOMEDCT_US:430099007	hp.json	Gross motor delay|Developmental delay, gross motor|Delayed gross motor skills|Delayed motor skills|Limited gross motor development	http://purl.obolibrary.org/obo/HP_0002194		
HP:0002191	biolink:PhenotypicFeature	Progressive spasticity	Spasticity that increases in degree with time.	UMLS:C1859520	hp.json	Spasticity, progressive	http://purl.obolibrary.org/obo/HP_0002191		
HP:0002197	biolink:PhenotypicFeature	Generalized-onset seizure	A generalized-onset seizure is a type of seizure originating at some point within, and rapidly engaging, bilaterally distributed networks. The networks may include cortical and subcortical structures but not necessarily the entire cortex.	UMLS:C0234533|SNOMEDCT_US:246545002|UMLS:C1833488|MSH:D012640	hp.json	Generalised seizures|Generalised-onset seizure|Generalised onset seizure|Generalized seizures|Primary generalised seizure|Generalized-onset seizures|Generalized onset seizure|Primary generalized seizure	http://purl.obolibrary.org/obo/HP_0002197		
HP:0002198	biolink:PhenotypicFeature	Dilated fourth ventricle	An abnormal dilatation of the fourth cerebral ventricle.	UMLS:C1847117	hp.json	Enlarged fourth ventricle	http://purl.obolibrary.org/obo/HP_0002198		
HP:0100668	biolink:PhenotypicFeature	Intestinal duplication	A developmental disorder in which there is a duplication the entire intestine or of a portion of the intestine.	SNOMEDCT_US:3845008|UMLS:C0266166|UMLS:C4020702	hp.json	Gut duplication|Bowel duplication	http://purl.obolibrary.org/obo/HP_0100668		
HP:0002195	biolink:PhenotypicFeature	Dysgenesis of the cerebellar vermis	Defective development of the vermis of cerebellum.	UMLS:C4025719	hp.json		http://purl.obolibrary.org/obo/HP_0002195		
HP:0100669	biolink:PhenotypicFeature	Abnormal pigmentation of the oral mucosa	An abnormality of the pigmentation of the mucosa of the mouth.	UMLS:C4020959	hp.json	Abnormal pigmentation of oral mucous membrane|Abnormal pigmentation of the oral mucosa/gingivae|Abnormal color of the oral mucosa|Abnormal pigmentation of oral cavity|Abnormal colour of the oral mucosa	http://purl.obolibrary.org/obo/HP_0100669		
HP:0002196	biolink:PhenotypicFeature	Myelopathy		SNOMEDCT_US:48522003|UMLS:C0037928|MSH:D013118	hp.json		http://purl.obolibrary.org/obo/HP_0002196		
HP:0100677	biolink:PhenotypicFeature	Vulval varicose vein	Varicosity of veins in the vulval region.	UMLS:C0155796|SNOMEDCT_US:48868008	hp.json		http://purl.obolibrary.org/obo/HP_0100677		
HP:0100678	biolink:PhenotypicFeature	Premature skin wrinkling	The presence of an increased degree of wrinkling (irregular folds and indentations) of the skin as compared with age-related norms.	MEDDRA:10040954|MSH:D015595|UMLS:C0037301|SNOMEDCT_US:247434009	hp.json	Wrinkled skin|Premature skin wrinkling	http://purl.obolibrary.org/obo/HP_0100678		hposlim_core
HP:0100675	biolink:PhenotypicFeature	Vaginal pyocele		UMLS:C4022000	hp.json		http://purl.obolibrary.org/obo/HP_0100675		
CHEBI:33909	biolink:ChemicalSubstance	metallotetrapyrrole			hp.json	metal-tetrapyrrole complex|metal-tetrapyrrole|metallotetrapyrroles	http://purl.obolibrary.org/obo/CHEBI_33909		3_STAR
HP:0100676	biolink:PhenotypicFeature	Vaginal lymphocele		UMLS:C4021999	hp.json		http://purl.obolibrary.org/obo/HP_0100676		
HP:0100673	biolink:PhenotypicFeature	Vaginal hydrocele	A type of hydrocele testis in which the processus vaginalis remains patent only around the testes, and, as fluid accumulates, it renders the testes impalpable.	UMLS:C1720771|SNOMEDCT_US:386152007|SNOMEDCT_US:26614003|MSH:D006848|SNOMEDCT_US:55434001	hp.json		http://purl.obolibrary.org/obo/HP_0100673		
HP:0100674	biolink:PhenotypicFeature	Vaginal hematocele		UMLS:C1456401	hp.json		http://purl.obolibrary.org/obo/HP_0100674		
HP:0100671	biolink:PhenotypicFeature	Abnormal trabecular bone morphology	Abnormal structure or form of trabecular bone.	UMLS:C4020957	hp.json	Abnormal shape of spongy bone|Abnormality of bone trabeculation	http://purl.obolibrary.org/obo/HP_0100671		
HP:0100672	biolink:PhenotypicFeature	Vaginal hernia	The presence of a hernia of the vagina.	SNOMEDCT_US:397786004|UMLS:C1442998	hp.json		http://purl.obolibrary.org/obo/HP_0100672		
HP:0100670	biolink:PhenotypicFeature	Coarse metaphyseal trabecularization	Coarse appearance of the components of the network of osseous tissue that makes up the cancellous structure of a bone, i.e., thickening of the (usually fine) white lines that are produced by trabeculae in radiograms.	UMLS:C4020958	hp.json	Rough bone trabeculation|Rough trabeculation of bone|Coarse trabeculation at metaphyses	http://purl.obolibrary.org/obo/HP_0100670		
GO:0042430	biolink:BiologicalProcess	indole-containing compound metabolic process	The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton.		hp.json	indole and derivative metabolism|indole derivative metabolism|ketole metabolic process|indole-containing compound metabolism|ketole metabolism|indole and derivative metabolic process|indole derivative metabolic process	http://purl.obolibrary.org/obo/GO_0042430		
CHEBI:33906	biolink:ChemicalSubstance	cobalt corrinoid			hp.json	cobalt corrinoids|cobalt-corrinoids	http://purl.obolibrary.org/obo/CHEBI_33906		3_STAR
RO:0002418	biolink:NamedThing	causally upstream of or within	p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.	RO:0002418	hp.json	affects	http://purl.obolibrary.org/obo/RO_0002418		
RO:0002411	biolink:NamedThing	causally upstream of	p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain	RO:0002411	hp.json		http://purl.obolibrary.org/obo/RO_0002411		http://purl.obolibrary.org/obo/valid_for_go_annotation_extension|http://purl.obolibrary.org/obo/valid_for_gocam
GO:0042435	biolink:BiologicalProcess	indole-containing compound biosynthetic process	The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton.		hp.json	indole-containing compound biosynthesis|indole-containing compound anabolism|indole derivative biosynthesis|indole derivative biosynthetic process|indole-containing compound synthesis|indole-containing compound formation	http://purl.obolibrary.org/obo/GO_0042435		
RO:0002412	biolink:NamedThing	immediately causally upstream of	p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p  must be an input of q.	RO:0002412	hp.json		http://purl.obolibrary.org/obo/RO_0002412		
HP:0100679	biolink:PhenotypicFeature	Lack of skin elasticity		UMLS:C0558242|SNOMEDCT_US:297957009|UMLS:C4021998	hp.json	Tight skin	http://purl.obolibrary.org/obo/HP_0100679		
HP:0100689	biolink:PhenotypicFeature	Decreased corneal thickness	A decreased anteroposterior thickness of the cornea.	SNOMEDCT_US:423459005|UMLS:C1096274	hp.json	Thin cornea	http://purl.obolibrary.org/obo/HP_0100689		
HP:0100686	biolink:PhenotypicFeature	Enthesitis		UMLS:C1282952|SNOMEDCT_US:359643005	hp.json	Inflammation of sharpey fibres|Inflammation of sharpey fibers	http://purl.obolibrary.org/obo/HP_0100686		
HP:0100687	biolink:PhenotypicFeature	Polyotia	The presence of an extra auricle on one or both sides of the head.	UMLS:C0266611|SNOMEDCT_US:35547002	hp.json		http://purl.obolibrary.org/obo/HP_0100687		
HP:0100684	biolink:PhenotypicFeature	Salivary gland neoplasm	A tumor (abnormal growth of tissue) of a salivary gland.	NCIT:C3262|SNOMEDCT_US:255072001|SNOMEDCT_US:235132004|UMLS:C0036095|MSH:D012468|UMLS:C0220636	hp.json	Tumour of salivary gland|Salivary gland neoplasia|Cancer of salivary gland|Tumor of salivary gland	http://purl.obolibrary.org/obo/HP_0100684		
HP:0100685	biolink:PhenotypicFeature	Abnormal Sharpey fiber morphology	An abnormality of Sharpey's fibers (bone fibers, or perforating fibers), which are a matrix of connective tissue consisting of bundles of strong collagenous fibres connecting periosteum to bone.	UMLS:C4020701|UMLS:C4021997	hp.json	Abnormality of Sharpey fibers|Enthesis abnormality|Abnormal Sharpey fibre morphology|Abnormality of Sharpey fibres	http://purl.obolibrary.org/obo/HP_0100685		
HP:0100682	biolink:PhenotypicFeature	Tracheal atresia	A congenital absence or considerable underdevelopment of the trachea such that communication between the larynx proximally and the alveoli of the lungs distally is lacking.	SNOMEDCT_US:53189005|UMLS:C0265766	hp.json		http://purl.obolibrary.org/obo/HP_0100682		
HP:0100681	biolink:PhenotypicFeature	Esophageal duplication	A developmental disorder in which there is a duplication of a portion of the muscle and submucosa of the esophagus without epithelial duplication.	UMLS:C0266135|SNOMEDCT_US:66865009	hp.json		http://purl.obolibrary.org/obo/HP_0100681		
RO:0002410	biolink:NamedThing	causally related to	This relation groups causal relations between material entities and causal relations between processes		hp.json		http://purl.obolibrary.org/obo/RO_0002410		
GO:0042440	biolink:BiologicalProcess	pigment metabolic process	The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.		hp.json	pigment metabolism	http://purl.obolibrary.org/obo/GO_0042440		goslim_pir|goslim_drosophila
RO:0002404	biolink:NamedThing	causally downstream of	inverse of upstream of	RO:0002404	hp.json		http://purl.obolibrary.org/obo/RO_0002404		
RO:0002405	biolink:NamedThing	immediately causally downstream of		RO:0002405	hp.json		http://purl.obolibrary.org/obo/RO_0002405		
GO:0042446	biolink:NamedThing	hormone biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0042446		
GO:0042445	biolink:NamedThing	hormone metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0042445		
HP:0100699	biolink:PhenotypicFeature	Scarring	A scar refers to a lesion in which wound, burn, or sore has not healed completely and fibrous connective tissue has developed.	SNOMEDCT_US:48677004|UMLS:C0008767|MSH:D002921	hp.json	Scarring|Scar tissue	http://purl.obolibrary.org/obo/HP_0100699		
HP:0100697	biolink:PhenotypicFeature	Neurofibrosarcoma	A form of malignant cancer of the connective tissue surrounding nerves. Given its origin and behavior, it is classified as a sarcoma.	NCIT:C3798|MSH:D009442|UMLS:C0751690|MSH:D018319|SNOMEDCT_US:404037002|SNOMEDCT_US:77418004|UMLS:C0206729|SNOMEDCT_US:19897006	hp.json	Malignant peripheral nerve sheath tumor|Neurosarcoma|Malignant peripheral nerve sheath tumour|Malignant schwannoma	http://purl.obolibrary.org/obo/HP_0100697		
HP:0100698	biolink:PhenotypicFeature	Subcutaneous neurofibromas	The presence of Neurofibromas in the subcutis.	SNOMEDCT_US:425327002|UMLS:C1827970	hp.json		http://purl.obolibrary.org/obo/HP_0100698		
HP:0100695	biolink:PhenotypicFeature	Lipedema	Excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise .	UMLS:C0398370|MSH:D065134|SNOMEDCT_US:234102003	hp.json		http://purl.obolibrary.org/obo/HP_0100695		
HP:0100693	biolink:PhenotypicFeature	Iridodonesis	Tremulousness of the iris on movement of the eye, occurring in subluxation of the lens.	SNOMEDCT_US:118166004|UMLS:C0423320	hp.json		http://purl.obolibrary.org/obo/HP_0100693		
HP:0100694	biolink:PhenotypicFeature	Tibial torsion	Twisted position of the tibia (shin bone) associated with pathological rotation of the leg.	UMLS:C0426900|SNOMEDCT_US:249785006	hp.json		http://purl.obolibrary.org/obo/HP_0100694		
HP:0100691	biolink:PhenotypicFeature	Abnormality of the curvature of the cornea		UMLS:C4021995	hp.json		http://purl.obolibrary.org/obo/HP_0100691		
HP:0100692	biolink:PhenotypicFeature	Increased corneal curvature	An increase in the degree of curvature of the cornea compared to normal.	UMLS:C4020956	hp.json	Steep corneal curvature	http://purl.obolibrary.org/obo/HP_0100692		
HP:0100690	biolink:PhenotypicFeature	Mosaic central corneal dystrophy		UMLS:C4021996	hp.json		http://purl.obolibrary.org/obo/HP_0100690		
GO:0042465	biolink:BiologicalProcess	kinesis	The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus.	Wikipedia:Kinesis	hp.json		http://purl.obolibrary.org/obo/GO_0042465		
GO:0042462	biolink:BiologicalProcess	eye photoreceptor cell development	Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.		hp.json		http://purl.obolibrary.org/obo/GO_0042462		
GO:0042461	biolink:BiologicalProcess	photoreceptor cell development	Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.		hp.json	photoreceptor morphogenesis	http://purl.obolibrary.org/obo/GO_0042461		
GO:0042475	biolink:BiologicalProcess	odontogenesis of dentin-containing tooth	The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.		hp.json	odontogeny|odontogenesis of dentine-containing teeth|odontogenesis of dentine-containing tooth|tooth development|odontosis	http://purl.obolibrary.org/obo/GO_0042475		
GO:0042476	biolink:BiologicalProcess	odontogenesis	The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.	Wikipedia:Odontogenesis	hp.json	tooth development|odontosis|odontogenesis of calcareous or chitinous tooth|tooth morphogenesis|odontogeny	http://purl.obolibrary.org/obo/GO_0042476		
GO:0042470	biolink:CellularComponent	melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.	Wikipedia:Melanosome	hp.json		http://purl.obolibrary.org/obo/GO_0042470		
GO:0042479	biolink:BiologicalProcess	positive regulation of eye photoreceptor cell development	Any process that activates or increases the frequency, rate or extent of eye photoreceptor development.		hp.json	positive regulation of eye photoreceptor development|upregulation of eye photoreceptor cell development|up regulation of eye photoreceptor cell development|stimulation of eye photoreceptor cell development|up-regulation of eye photoreceptor cell development|activation of eye photoreceptor cell development	http://purl.obolibrary.org/obo/GO_0042479		
GO:0042478	biolink:BiologicalProcess	regulation of eye photoreceptor cell development	Any process that modulates the frequency, rate or extent of eye photoreceptor development.		hp.json	regulation of eye photoreceptor development	http://purl.obolibrary.org/obo/GO_0042478		
CHEBI:18240	biolink:ChemicalSubstance	4-hydroxy-L-proline	The L-stereoisomer of 4-hydroxyproline.	KNApSAcK:C00001370|Wikipedia:4-hydroxy-L-proline|CAS:51-35-4|KEGG:C01015|HMDB:HMDB0006055|Reaxys:81441	hp.json	4-Hydroxy-L-proline|(2S)-4-hydroxypyrrolidine-2-carboxylic acid|hydroxy-L-proline|cis-4-Hydroxy-L-Proline|4-hydroxy-L-proline|L-Hydroxyproline	http://purl.obolibrary.org/obo/CHEBI_18240		3_STAR
NBO:0000851	biolink:NamedThing	increased amount of liquid in a single drinking act			hp.json		http://purl.obolibrary.org/obo/NBO_0000851		
HP:0002135	biolink:PhenotypicFeature	Basal ganglia calcification	The presence of calcium deposition affecting one or more structures of the basal ganglia.	UMLS:C1389280	hp.json	Calcification of the basal ganglia|Basal ganglia calcifications|Basal ganglion calcification	http://purl.obolibrary.org/obo/HP_0002135		
HP:0004798	biolink:PhenotypicFeature	Recurrent infection of the gastrointestinal tract	Recurrent infection of the gastrointestinal tract.	SNOMEDCT_US:715852004|UMLS:C1854495|UMLS:C4082764	hp.json	Gastrointestinal infections|Recurrent infection of the GI tract|Gastrointestinal infections, recurrent|Recurrent gastrointestinal infections|Recurrent infection of the gastrointestinal tract	http://purl.obolibrary.org/obo/HP_0004798		
HP:0002136	biolink:PhenotypicFeature	Broad-based gait	An abnormal gait pattern in which persons stand and walk with their feet spaced widely apart. This is often a component of cerebellar ataxia.	UMLS:C0856863	hp.json	Broad based gait|Wide based gait|Wide based walk|Wide-based gait	http://purl.obolibrary.org/obo/HP_0002136		
HP:0004797	biolink:PhenotypicFeature	Multiple small bowel atresias	The presence of multiple areas of atresia affecting the small intestine.	UMLS:C1857476	hp.json		http://purl.obolibrary.org/obo/HP_0004797		
HP:0004796	biolink:PhenotypicFeature	Gastrointestinal obstruction		SNOMEDCT_US:126765001|UMLS:C0236124	hp.json	Obstruction in digestive tract|Gastrointestinal obstruction|GI obstruction	http://purl.obolibrary.org/obo/HP_0004796		
HP:0002133	biolink:PhenotypicFeature	Status epilepticus	Status epilepticus is a type of prolonged seizure resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms which lead to abnormally prolonged seizures (after time point t1). It is a condition that can have long-term consequences (after time point t2), including neuronal death, neuronal injury, and alteration of neuronal networks, depending on the type and duration of seizures.	UMLS:C0038220|MSH:D013226|SNOMEDCT_US:230456007	hp.json	Repeated seizures without recovery between them|Repeated seizure without recovery|Prolonged seizure	http://purl.obolibrary.org/obo/HP_0002133		
UBERON:0006440	biolink:AnatomicalEntity	os clitoris	The ossified region of endochondral and membranous bone located in the clitoris of most mammals except humans; it is homologous to the penile bone (aka as baculum, penis bone or os penis) in male mammals.	EMAPA:30823|MA:0000387	hp.json	clitoral bone|baubellum|os clitoridis|clitoris bone	http://purl.obolibrary.org/obo/UBERON_0006440		pheno_slim
HP:0002134	biolink:PhenotypicFeature	Abnormal basal ganglia morphology	Abnormality of the basal ganglia.	UMLS:C0004782|SNOMEDCT_US:70835005|MSH:D001480	hp.json	Anomaly of the basal ganglia|Abnormality of the basal ganglia|Basal ganglia disease	http://purl.obolibrary.org/obo/HP_0002134		
HP:0004795	biolink:PhenotypicFeature	Hamartomatous stomach polyps	Polyp-like protrusions which are histologically hamartomas located in the stomach.	UMLS:C1862304	hp.json		http://purl.obolibrary.org/obo/HP_0004795		
HP:0002139	biolink:PhenotypicFeature	Arrhinencephaly		MSH:D016142|UMLS:C0078982	hp.json		http://purl.obolibrary.org/obo/HP_0002139		
HP:0002138	biolink:PhenotypicFeature	Subarachnoid hemorrhage	Hemorrhage occurring between the arachnoid mater and the pia mater.	MSH:D013345|UMLS:C0038525|SNOMEDCT_US:21454007	hp.json	Subarachnoid haemorrhage	http://purl.obolibrary.org/obo/HP_0002138		
HP:0004799	biolink:PhenotypicFeature	Jejunoileal diverticula		UMLS:C4025290	hp.json		http://purl.obolibrary.org/obo/HP_0004799		
HP:0004790	biolink:PhenotypicFeature	Hypoplasia of the small intestine	Underdevelopment of the small intestine.	UMLS:C4025291	hp.json	Underdeveloped small intestine	http://purl.obolibrary.org/obo/HP_0004790		
CHEBI:18237	biolink:ChemicalSubstance	glutamic acid	An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	Wikipedia:Glutamic_acid|PMID:17190852|KNApSAcK:C00019577|CAS:617-65-2|CAS:617-65-2|CAS:617-65-2|PMID:24984001|KEGG:D04341|Gmelin:101971|Reaxys:1723799|Beilstein:1723799|KNApSAcK:C00001358|PMID:15739367|PMID:24616376|KEGG:C00302	hp.json	Glutamate|Glutaminsaeure|Glutaminic acid|E|2-aminopentanedioic acid|glutamic acid|2-Aminoglutaric acid|DL-Glutaminic acid|DL-Glutamic acid|Glu|Glutamic acid	http://purl.obolibrary.org/obo/CHEBI_18237		3_STAR
HP:0004794	biolink:PhenotypicFeature	Malrotation of small bowel	A deviation from the normal rotation of the midgut during embryologic development with mislocalization of the small bowel.	UMLS:C1860244	hp.json	Malrotation of the small intestine	http://purl.obolibrary.org/obo/HP_0004794		
HP:0002131	biolink:PhenotypicFeature	Episodic ataxia	Periodic spells of incoordination and imbalance, that is, episodes of ataxia typically lasting from 10 minutes to several hours or days.	SNOMEDCT_US:421455009|MSH:C580065|UMLS:C1720189	hp.json	Paroxysmal ataxia|Intermittent cerebellar ataxia	http://purl.obolibrary.org/obo/HP_0002131		
HP:0002132	biolink:PhenotypicFeature	Porencephalic cyst	A cavity within the cerebral hemisphere, filled with cerebrospinal fluid, that communicates directly with the ventricular system.	UMLS:C4082173|MSH:D065708	hp.json	Cavity within brain	http://purl.obolibrary.org/obo/HP_0002132		
HP:0004792	biolink:PhenotypicFeature	Rectoperineal fistula	The presence of a fistula between the perineum and the rectum.	UMLS:C0240880	hp.json		http://purl.obolibrary.org/obo/HP_0004792		
UBERON:0006444	biolink:AnatomicalEntity	annulus fibrosus	A ring of fibrous or fibrocartilaginous tissue (as of an intervertebral disk or surrounding an orifice of the heart).	FMA:76704|MESH:D000070616|BTO:0003627|EMAPA:32670	hp.json	anulus|anulus fibrosus|fibrous ring|fibrocartilaginous ring	http://purl.obolibrary.org/obo/UBERON_0006444		grouping_class
HP:0004791	biolink:PhenotypicFeature	Esophageal ulceration	Defect in the epithelium of the esophagus, essentially an open sore in the lining of the esophagus.	UMLS:C0151970|SNOMEDCT_US:30811009	hp.json	Esophagus ulcer|Oesophagus ulcer|Oesophagus ulceration	http://purl.obolibrary.org/obo/HP_0004791		
UBERON:0018411	biolink:AnatomicalEntity	ligament of hip joint	A skeletal ligament that is part of a hip joint.	FMA:42868	hp.json	hip joint ligament	http://purl.obolibrary.org/obo/UBERON_0018411		
CHEBI:33888	biolink:ChemicalSubstance	cobalt molecular entity			hp.json	cobalt molecular entities|cobalt compounds|cobalt molecular entity	http://purl.obolibrary.org/obo/CHEBI_33888		3_STAR
UBERON:0018415	biolink:AnatomicalEntity	ethmoid foramen	An bone foramen in the ethmoid bone.		hp.json	ethmoid foramina|ethmoidal foramen|ethmoidal foramina|foramina ethmoidalia	http://purl.obolibrary.org/obo/UBERON_0018415		
UBERON:0018413	biolink:AnatomicalEntity	facial nerve canal	A Z-shaped canal running through the temporal bone from the internal acoustic meatus to the stylomastoid foramen. It is located within the middle ear region, according to its shape it is divided into three main segments: the labyrinthine, the tympanic, and the mastoidal segment .	FMA:54952	hp.json	facial canal|fallopian canal|canalis nervi facialis	http://purl.obolibrary.org/obo/UBERON_0018413		
UBERON:0006431	biolink:AnatomicalEntity	xiphoid process bone	A bone tissue that is part of a xiphoid process.	FMA:32577|GAID:248	hp.json	xiphoid bone|bone tissue of xiphoid process	http://purl.obolibrary.org/obo/UBERON_0006431		
UBERON:0006430	biolink:AnatomicalEntity	xiphoid cartilage	A costal cartilage that is part of a xiphoid process.	MA:0001884|AAO:0000940|FMA:32574|EMAPA:18725	hp.json	xiphoid cartilage|ensiform cartilage|xiphoid process cartilage|cartilage of xiphoid process	http://purl.obolibrary.org/obo/UBERON_0006430		pheno_slim|uberon_slim
HP:0002144	biolink:PhenotypicFeature	Tethered cord	During normal embryological development, the spinal cord first occupies the entire length of the vertebral column but goes on to assume a position at the level of L1 due to differential growth of the conus medullaris and the vertebral column. The filum terminale is a slender, threadlike structure that remains after the normal regression of the distal embryonic spinal cord and attaches the spinal cord to the coccyx. A tethered cord results if there is a thickened rope-like filum terminale which anchors the cord at the level of L2 or below, potentially causing neurologic signs owing to abnormal tension on the spinal cord.	MSH:D009436|UMLS:C0080218|SNOMEDCT_US:70534000	hp.json	Occult spinal dysraphism	http://purl.obolibrary.org/obo/HP_0002144		
HP:0002145	biolink:PhenotypicFeature	Frontotemporal dementia	A dementia associated with degeneration of the frontotemporal lobe and clinically associated with personality and behavioral changes such as disinhibition, apathy, and lack of insight. The hallmark feature of frontotemporal dementia is the presentation with focal syndromes such as progressive language dysfunction, or aphasia, or behavioral changes characteristic of frontal lobe disorders.	MSH:D057180|UMLS:C0338451|SNOMEDCT_US:230270009	hp.json		http://purl.obolibrary.org/obo/HP_0002145		
HP:0002148	biolink:PhenotypicFeature	Hypophosphatemia	An abnormally decreased phosphate concentration in the blood.	UMLS:C0085682|MSH:D017674|SNOMEDCT_US:4996001	hp.json	Low blood phosphate level|Hypophosphataemia	http://purl.obolibrary.org/obo/HP_0002148		
HP:0002149	biolink:PhenotypicFeature	Hyperuricemia	An abnormally high level of uric acid in the blood.	UMLS:C0740394|MSH:D033461|SNOMEDCT_US:35885006	hp.json	High blood uric acid level|Hyperuricaemia	http://purl.obolibrary.org/obo/HP_0002149		
NCBITaxon:186623	biolink:OrganismalEntity	Actinopteri		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_186623		
HP:0002143	biolink:PhenotypicFeature	Abnormality of the spinal cord	An abnormality of the spinal cord (myelon).	UMLS:C0037928|MSH:D013118|UMLS:C4025722|SNOMEDCT_US:48522003	hp.json	Spinal cord disease|Spinal cord pathology|Abnormality of the spinal cord	http://purl.obolibrary.org/obo/HP_0002143		
UBERON:0006435	biolink:AnatomicalEntity	os penis	The unique bone located in the glans penis of most mammals except humans; it is used for copulation and varies in size and shape by species.	MA:0000406|EMAPA:29769	hp.json	baculum|penis bone|penile bone|penile bone|os baculum	http://purl.obolibrary.org/obo/UBERON_0006435		pheno_slim
HP:0002140	biolink:PhenotypicFeature	Ischemic stroke	Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured.	UMLS:C0948008|SNOMEDCT_US:422504002	hp.json	Ischaemic stroke	http://purl.obolibrary.org/obo/HP_0002140		
HP:0002141	biolink:PhenotypicFeature	Gait imbalance		UMLS:C1836150	hp.json	Abnormality of balance|Abnormality of equilibrium|Imbalanced walk	http://purl.obolibrary.org/obo/HP_0002141		
HP:0100700	biolink:PhenotypicFeature	Abnormal arachnoid mater morphology	An abnormality of the Arachnoid mater.	UMLS:C4020955	hp.json	Abnormality of the arachnoid mater|Abnormality of the arachnoidea	http://purl.obolibrary.org/obo/HP_0100700		
CHEBI:33856	biolink:ChemicalSubstance	aromatic amino acid	An amino acid whose structure includes an aromatic ring.	KEGG:C01021|Wikipedia:Aromatic_amino_acid	hp.json	aromatic amino acids|Aromatic amino acid	http://purl.obolibrary.org/obo/CHEBI_33856		3_STAR
UBERON:0018408	biolink:AnatomicalEntity	infra-orbital nerve	A branch of the maxillary nerve that enters the infraorbital canal and innervates the lower eyelid, upper lip, the nasal vestibule, the upper incisors, canines, premolars, upper gums, lower eyelid and conjunctiva, and part of the nose.	FMA:52978	hp.json	infraorbital portion|infraorbital nerve|infra-orbital nerve	http://purl.obolibrary.org/obo/UBERON_0018408		
HP:0002119	biolink:PhenotypicFeature	Ventriculomegaly	An increase in size of the ventricular system of the brain.	UMLS:C3278923	hp.json	Enlarged ventricular system|Cerebral ventricular dilatation|Dilated cerebral ventricles|Ventricular dilatation|Dilated ventricles|Dilated cerebral ventricle|Enlarged cerebral ventricles|Large cerebral ventricles and cisternae|Enlarged ventricles	http://purl.obolibrary.org/obo/HP_0002119		
UBERON:0018405	biolink:AnatomicalEntity	inferior alveolar nerve		FMA:53243	hp.json	inferior dental nerve	http://purl.obolibrary.org/obo/UBERON_0018405		
UBERON:0018406	biolink:AnatomicalEntity	mental nerve	Mental nerve is a general somatic afferent (sensory) nerve which provides sensation to the anterior aspects of the chin and lower lip as well as the buccal gingivae of the mandibular anterior teeth and the premolars. It is a branch of the posterior trunk of the inferior alveolar nerve, which is itself a branch of the mandibular division of the trigeminal nerve (CN V). The nerve emerges at the mental foramen in the mandibula, and divides beneath the Depressor anguli oris muscle into three branches: one descends to the skin of the chin. two ascend to the skin and mucous membrane of the lower lip. These branches communicate freely with the facial nerve.	FMA:53250	hp.json		http://purl.obolibrary.org/obo/UBERON_0018406		
CHEBI:33859	biolink:ChemicalSubstance	aromatic carboxylic acid	Any carboxylic acid in which the carboxy group is directly bonded to an aromatic ring.		hp.json	aromatic carboxylic acids	http://purl.obolibrary.org/obo/CHEBI_33859		3_STAR
HP:0002113	biolink:PhenotypicFeature	Pulmonary infiltrates		UMLS:C0235896	hp.json	Pulmonic infiltration|Lung infiltrates	http://purl.obolibrary.org/obo/HP_0002113		
HP:0002111	biolink:PhenotypicFeature	obsolete Restrictive deficit on pulmonary function testing			hp.json		http://purl.obolibrary.org/obo/HP_0002111		
HP:0004779	biolink:PhenotypicFeature	Brittle scalp hair	Fragile, easily breakable scalp hair.	UMLS:C4025296	hp.json	Brittle scalp hair	http://purl.obolibrary.org/obo/HP_0004779		
HP:0002118	biolink:PhenotypicFeature	Abnormal cerebral ventricle morphology	Any structural abnormality of the cerebral ventricles.	UMLS:C4025724	hp.json	Abnormality of the cerebral ventricles	http://purl.obolibrary.org/obo/HP_0002118		
CHEBI:33853	biolink:ChemicalSubstance	phenols	Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.	KEGG:C15584|MetaCyc:Phenols|Wikipedia:Phenols	hp.json	phenols|a phenol|arenols|Aryl alcohol	http://purl.obolibrary.org/obo/CHEBI_33853		3_STAR
HP:0100709	biolink:PhenotypicFeature	Reduction of oligodendroglia		UMLS:C4021852	hp.json		http://purl.obolibrary.org/obo/HP_0100709		
CHEBI:18258	biolink:ChemicalSubstance	3,3',5-triiodo-L-thyronine	An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.	KEGG:C02465|LINCS:LSM-3991|Wikipedia:Triiodothyronine|KEGG:D08128|Beilstein:2710227|Reaxys:2710227|PMID:19339791|DrugBank:DB00279|HMDB:HMDB0000265|PDBeChem:T3|PMID:15206581|PMID:11738632|CAS:6893-02-3|MetaCyc:CPD-10813|CAS:6893-02-3|Drug_Central:1585	hp.json	Liothyronine|3,5,3'-Triiodothyronine|L-3,5,3'-Triiodothyronine|T3|L-T3|O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine|liothyroninum|4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-L-phenylalanine|liothyronine|3,5,3'-Triiodo-L-thyronine|Triiodothyronine|T3|3,5,3'TRIIODOTHYRONINE|3,3',5-triiodo-L-thyronine|Tresitope|Tertroxin|liothyronine|liotironina	http://purl.obolibrary.org/obo/CHEBI_18258		3_STAR
HP:0100707	biolink:PhenotypicFeature	Abnormal astrocyte morphology	An abnormality of astrocytes.	UMLS:C4021991	hp.json	Abnormality of the astrocytes	http://purl.obolibrary.org/obo/HP_0100707		
CHEBI:18259	biolink:ChemicalSubstance	N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide	A glycotetraosylceramide having N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose as the tetrasaccharide component.	PMID:15495792|PMID:7690848|PMID:4026313|PMID:15661151|PMID:1528196|PMID:21376640|PMID:8161226|PMID:21252262|KEGG:C03272|PMID:2456994|CAS:11034-93-8|CAS:11034-93-8|KEGG:G00094|PMID:7691279|PMID:1724444|PMID:7287743|PMID:3220436|PMID:1601891|PMID:2448252	hp.json	Gb4 Globotetraosyl ceramide|GalNAc-1->3-Gal-1->4-Gal-1->4-Glc-Cer|(Gal)2 (GalNAc)1 (Glc)1 (Cer)1|N-Acetyl-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide|globoside Gb4Cer (d18:1(4E))|Gbose4Cer|beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer|N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosylceramides|N-[(2S,3R,4E)-1-{[2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->3)-alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]alkanamide|Globoside GL-4|GbOse4Cer|CTH/Gb4|Globotetraosyl ceramide|N-Acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide|Globoside I|VT2vp1 Receptor|Slt-iiv receptor|Gb4Cer|Gb4Cer|Gb4 Globoside|beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer|GalNAcbeta1-3-Galalpha1-4Galbeta1-4Glcbeta1-1Cer	http://purl.obolibrary.org/obo/CHEBI_18259		3_STAR
HP:0100708	biolink:PhenotypicFeature	Abnormal microglia morphology	An abnormality of the microglial cells. They are also known as brain-resident macrophages or hortega cells.	UMLS:C4021990	hp.json	Abnormality of the microglia	http://purl.obolibrary.org/obo/HP_0100708		
HP:0100705	biolink:PhenotypicFeature	Abnormal glial cell morphology	An abnormality of the glia cell.	UMLS:C4021993	hp.json	Abnormality of the glial cells	http://purl.obolibrary.org/obo/HP_0100705		
CHEBI:18257	biolink:ChemicalSubstance	ornithine	An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5.	PMID:17190852|CAS:616-07-9|KEGG:C01602|PMID:15449570|PMID:22264337|Reaxys:1722296|Beilstein:1722296|KNApSAcK:C00001384|Gmelin:847696	hp.json	2,5-diaminopentanoic acid|2,5-Diaminovaleric acid|ornithine|DL-Ornithine|Orn|Ornithine|2,5-Diaminopentanoic acid	http://purl.obolibrary.org/obo/CHEBI_18257		3_STAR
HP:0100706	biolink:PhenotypicFeature	Abnormal oligodendroglia morphology	One of the three types of glia cells that, with the nerve cells, compose the central nervous system and are characterized by sheetlike processes that wrap around individual axons to form the myelin sheath of nerve fibers.	UMLS:C4021992	hp.json	Abnormality of the oligodendroglia	http://purl.obolibrary.org/obo/HP_0100706		
HP:0100703	biolink:PhenotypicFeature	Tongue thrusting		SNOMEDCT_US:110343009|UMLS:C1829460|SNOMEDCT_US:424583005	hp.json	Tongue thrusting	http://purl.obolibrary.org/obo/HP_0100703		
HP:0100704	biolink:PhenotypicFeature	Cerebral visual impairment	A form of loss of vision caused by damage to the visual cortex rather than a defect in the eye.	SNOMEDCT_US:68574006|UMLS:C4048268|UMLS:C0155320|MSH:D019575|SNOMEDCT_US:413924001	hp.json	CVI|Cortical blindness|Cortical visual impairment|Cortical/cerebral visual impairment	http://purl.obolibrary.org/obo/HP_0100704		
HP:0002110	biolink:PhenotypicFeature	Bronchiectasis	Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways.	UMLS:C0006267|MSH:D001987|SNOMEDCT_US:12295008	hp.json	Permanent enlargement of the airways of the lungs	http://purl.obolibrary.org/obo/HP_0002110		
HP:0004771	biolink:PhenotypicFeature	Premature graying of body hair		UMLS:C1849125	hp.json	Premature graying of body hair|Premature greying of body hair	http://purl.obolibrary.org/obo/HP_0004771		
HP:0100701	biolink:PhenotypicFeature	Abnormal pia mater	An abnormality of the pia mater.	UMLS:C4021994	hp.json	Abnormality of the pia mater	http://purl.obolibrary.org/obo/HP_0100701		
HP:0100702	biolink:PhenotypicFeature	Arachnoid cyst	An extra-parenchymal and intra-arachnoidal collection of fluid with a composition similar to that of cerebrospinal fluid.	MSH:D016080|SNOMEDCT_US:33595009|UMLS:C0078981	hp.json	Fluid-filled sac located in membrane surrounding brain or spinal cord|Arachnoid cysts	http://purl.obolibrary.org/obo/HP_0100702		
HP:0100710	biolink:PhenotypicFeature	Impulsivity	Acting on the spur of the moment in response to immediate stimuli; acting on a momentary basis without a plan or consideration of outcomes; difficulty establishing or following plans; a sense of urgency and self-harming behavior under emotional distress.	UMLS:C0021125|MSH:D007175	hp.json	Impulsive|Impulsivity	http://purl.obolibrary.org/obo/HP_0100710		
HP:0100711	biolink:PhenotypicFeature	Abnormal thoracic spine morphology	An abnormality of the thoracic vertebral column.	UMLS:C4021989	hp.json	Abnormality of the thoracic spine	http://purl.obolibrary.org/obo/HP_0100711		
HP:0004787	biolink:PhenotypicFeature	Fulminant hepatitis	Acute hepatitis complicated by acute liver failure with hepatic encephalopathy occurring less than 8 weeks after the onset of jaundice.	UMLS:C0302809|SNOMEDCT_US:427044009	hp.json		http://purl.obolibrary.org/obo/HP_0004787		
HP:0004786	biolink:PhenotypicFeature	Jejunal diverticula		UMLS:C4025293	hp.json		http://purl.obolibrary.org/obo/HP_0004786		
HP:0004785	biolink:PhenotypicFeature	Malrotation of colon	An anatomical anomaly that results from an abnormal rotation of the gut as it returns to the abdominal cavity during embryogenesis.	UMLS:C0266196|SNOMEDCT_US:6477005	hp.json		http://purl.obolibrary.org/obo/HP_0004785		
HP:0002123	biolink:PhenotypicFeature	Generalized myoclonic seizure	A generalized myoclonic seizure is a type of generalized motor seizure characterised by bilateral, sudden, brief (<100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography (axial, proximal limb, distal). Myoclonus is less regularly repetitive and less sustained than is clonus.	UMLS:C4021759|MSH:D020191|UMLS:C0014550|SNOMEDCT_US:267581004|MSH:D004831|UMLS:C0751778|SNOMEDCT_US:37356005|SNOMEDCT_US:192992007	hp.json	Generalised myoclonic seizures|Myoclonic epilepsy, progressive|Generalized epileptic myoclonus|Myoclonus seizures|Generalized myoclonic seizures|Generalised epileptic myoclonus|Generalised myoclonic seizure	http://purl.obolibrary.org/obo/HP_0002123		
HP:0004784	biolink:PhenotypicFeature	Juvenile gastrointestinal polyposis	The presence of multiple juvenile polyps in the stomach and intestine. The term juvenile polyps refer to a special histopathology and not the age of onset as the polyp might be diagnosed at all ages. The juvenile polyp has a spherical appearance and is microscopically characterized by overgrowth of an oedematous lamina propria with inflammatory cells and cystic glands. Juvenile polyps are a specific type of hamartomatous polyps.	UMLS:C4025294	hp.json	Juvenile GI polyposis	http://purl.obolibrary.org/obo/HP_0004784		
CHEBI:33861	biolink:ChemicalSubstance	transition element coordination entity			hp.json	transition metal coordination entities|transition element coordination entities|transition metal coordination compounds	http://purl.obolibrary.org/obo/CHEBI_33861		3_STAR
HP:0002126	biolink:PhenotypicFeature	Polymicrogyria	Polymicrogyria is a congenital malformation of the cerebral cortex characterized by abnormal cortical layering (lamination) and an excessive number of small gyri (folds).	UMLS:C0266464|SNOMEDCT_US:4945003|MSH:D065706	hp.json	More grooves in brain	http://purl.obolibrary.org/obo/HP_0002126		
HP:0004789	biolink:PhenotypicFeature	Lactose intolerance	An inability to digest lactose.	SNOMEDCT_US:267425008|UMLS:C0022951|MSH:D007787|SNOMEDCT_US:700094005	hp.json	Lactose intolerance|Milk intolerance	http://purl.obolibrary.org/obo/HP_0004789		
HP:0004788	biolink:PhenotypicFeature	Intestinal lymphedema	Fluid retention and edema in the intestine caused by a compromised lymphatic system.	UMLS:C4025292	hp.json		http://purl.obolibrary.org/obo/HP_0004788		
HP:0002127	biolink:PhenotypicFeature	Abnormal upper motor neuron morphology	Any structural anomaly that affects the upper motor neuron.	UMLS:C4025723	hp.json	Abnormal shape of upper motor neuron	http://purl.obolibrary.org/obo/HP_0002127		
HP:0100718	biolink:PhenotypicFeature	Uterine rupture		SNOMEDCT_US:34430009|MSH:D014597|UMLS:C0042143	hp.json		http://purl.obolibrary.org/obo/HP_0100718		
CHEBI:18248	biolink:ChemicalSubstance	iron atom	An iron group element atom that has atomic number 26.	CAS:7439-89-6|KEGG:C00023|WebElements:Fe|CAS:7439-89-6|HMDB:HMDB0015531|Reaxys:4122945|CAS:7439-89-6|DrugBank:DB01592	hp.json	hierro|iron|Eisen|ferrum|iron|26Fe|fer|Fe|Fe|Iron	http://purl.obolibrary.org/obo/CHEBI_18248		3_STAR
HP:0100719	biolink:PhenotypicFeature	Lens coloboma	A sectoral indentation of the crystalline lens, usually due to zonular weakness or absence.	UMLS:C0344516|SNOMEDCT_US:204134008	hp.json		http://purl.obolibrary.org/obo/HP_0100719		hposlim_core
HP:0100716	biolink:PhenotypicFeature	Self-injurious behavior	Aggression towards oneself.	SNOMEDCT_US:248062006|UMLS:C0085271|MSH:D016728	hp.json	Autoagression|Self-injurious behaviours|Self injury|Self-injurious behaviour|Self-harm|Self-injurious behavior|Self-injurious behaviors	http://purl.obolibrary.org/obo/HP_0100716		
HP:0100717	biolink:PhenotypicFeature	Abnormal cementum morphology	Any structural anomaly of the cementum, which is the mineralized connective tissue covering the dental root. The cementum allows anchoring of the fibers of the periodontal ligament. Cementum is secreted by cementoblasts, which may be, later on, embedded in the cementum. Cementum can be acellular (along the two third coronal portion of the root) and cellular (in the apical and interradicular part of the root).	UMLS:C4021987	hp.json	Abnormality of the cementum	http://purl.obolibrary.org/obo/HP_0100717		
HP:0004783	biolink:PhenotypicFeature	Duodenal polyposis	Presence of multiple polyps in the duodenum.	UMLS:C0578477|SNOMEDCT_US:301797007	hp.json	Multiple duodenal polyps	http://purl.obolibrary.org/obo/HP_0004783		
CHEBI:18243	biolink:ChemicalSubstance	dopamine	Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.	DrugBank:DB00988|KNApSAcK:C00001408|PMID:11149432|KEGG:D07870|PMID:9422813|PMID:10629745|Reaxys:1072822|KEGG:C03758|Drug_Central:947|Wikipedia:Dopamine|HMDB:HMDB0000073|MetaCyc:DOPAMINE|LINCS:LSM-4630|CAS:51-61-6	hp.json	Hydroxytyramin|Deoxyepinephrine|2-(3,4-Dihydroxyphenyl)ethylamine|4-(2-aminoethyl)catechol|dopaminum|4-(2-Aminoethyl)-1,2-benzenediol|dopamina|3-Hydroxytyramine|2-(3,4-dihydroxyphenyl)ethylamine|4-(2-Aminoethyl)benzene-1,2-diol|4-(2-aminoethyl)-1,2-benzenediol|dopamine|4-(2-aminoethyl)pyrocatechol|Dopamine|4-(2-aminoethyl)benzene-1,2-diol|3,4-Dihydroxyphenethylamine	http://purl.obolibrary.org/obo/CHEBI_18243		3_STAR
HP:0002120	biolink:PhenotypicFeature	Cerebral cortical atrophy	Atrophy of the cortex of the cerebrum.	SNOMEDCT_US:278849000|UMLS:C0235946	hp.json	Cortical atrophy|Cerebral cortex atrophy|Decrease in size of the outer layer of the brain due to loss of brain cells	http://purl.obolibrary.org/obo/HP_0002120		
HP:0002121	biolink:PhenotypicFeature	Generalized non-motor (absence) seizure	A generalized non-motor (absence) seizure is a type of a type of dialeptic seizure that is of electrographically generalized onset. It is a generalized seizure characterised by an interruption of activities, a blank stare, and usually the person will be unresponsive when spoken to. Any ictal motor phenomena are minor in comparison to these non-motor features.	SNOMEDCT_US:230413002|MSH:D004832|SNOMEDCT_US:432241000124101|SNOMEDCT_US:79631006|SNOMEDCT_US:50866000|UMLS:C0014553	hp.json	Petit mal seizure|Brief seizures with staring spells|Absence seizures|Absence seizure|Petit mal|Generalised non-motor (absence) seizure|Petit mal seizures|Generalised non-motor seizure	http://purl.obolibrary.org/obo/HP_0002121		
HP:0004782	biolink:PhenotypicFeature	obsolete Hypotrichosis of the scalp			hp.json		http://purl.obolibrary.org/obo/HP_0004782		
HP:0100712	biolink:PhenotypicFeature	Abnormal lumbar spine morphology	Any structural abnormality of the lumbar vertebral column.	UMLS:C4021988	hp.json	Abnormality of the lumbar spine	http://purl.obolibrary.org/obo/HP_0100712		
HP:0004780	biolink:PhenotypicFeature	Elbow hypertrichosis	Excessive, increased hair growth located in the elbow region.	UMLS:C4025295	hp.json	Hypertrichosis cubiti|Pilosity of elbow|Hairy elbow|Hairy elbow syndrome	http://purl.obolibrary.org/obo/HP_0004780		
HP:0100721	biolink:PhenotypicFeature	Mediastinal lymphadenopathy	Swelling of lymph nodes within the mediastinum, the central compartment of the thoracic cavities that contains the heart and the great vessels, the esophagus, and trachea and other structures including lymph nodes.	UMLS:C0520743|SNOMEDCT_US:52324001	hp.json	Swollen lymph nodes in center of chest|Swollen lymph nodes in centre of chest	http://purl.obolibrary.org/obo/HP_0100721		
HP:0100720	biolink:PhenotypicFeature	Hypoplasia of the ear cartilage		UMLS:C4021986	hp.json	Underdeveloped ear cartilage	http://purl.obolibrary.org/obo/HP_0100720		
CHEBI:33833	biolink:ChemicalSubstance	heteroarene	A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2).		hp.json	heteroarenes|hetarenes	http://purl.obolibrary.org/obo/CHEBI_33833		3_STAR
CHEBI:33836	biolink:ChemicalSubstance	benzenoid aromatic compound			hp.json	benzenoid compound|benzenoid aromatic compounds	http://purl.obolibrary.org/obo/CHEBI_33836		3_STAR
CHEBI:33837	biolink:ChemicalSubstance	conjugated protein	Conjugated protein is a protein that contains a non-peptide component, usually in stoichiometric proportion.	COMe:PRX000001	hp.json	conjugated proteins|complex protein	http://purl.obolibrary.org/obo/CHEBI_33837		3_STAR
CHEBI:33839	biolink:ChemicalSubstance	macromolecule	A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.	Wikipedia:Macromolecule	hp.json	polymer|polymer molecule|polymers|macromolecule|macromolecules	http://purl.obolibrary.org/obo/CHEBI_33839		3_STAR
HP:0002179	biolink:PhenotypicFeature	Opisthotonus		UMLS:C0151818|SNOMEDCT_US:8652009	hp.json	Opisthotonos	http://purl.obolibrary.org/obo/HP_0002179		
CHEBI:33832	biolink:ChemicalSubstance	organic cyclic compound	Any organic molecule that consists of atoms connected in the form of a ring.		hp.json	organic cyclic compounds	http://purl.obolibrary.org/obo/CHEBI_33832		3_STAR
HP:0002171	biolink:PhenotypicFeature	Gliosis	Gliosis is the focal proliferation of glial cells in the central nervous system.	SNOMEDCT_US:359580009|SNOMEDCT_US:81415000|MSH:D005911|UMLS:C0017639	hp.json	Excess astrocytes in brain|Cerebral gliosis	http://purl.obolibrary.org/obo/HP_0002171		
HP:0100729	biolink:PhenotypicFeature	Large face		UMLS:C2748652	hp.json	Large facies|Large face|Big face	http://purl.obolibrary.org/obo/HP_0100729		
HP:0002172	biolink:PhenotypicFeature	Postural instability	A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps.	UMLS:C1843921	hp.json	Balance impairment|Abnormal retropulsion test|Imbalance	http://purl.obolibrary.org/obo/HP_0002172		
HP:0100727	biolink:PhenotypicFeature	Histiocytosis	An excessive number of histiocytes (tissue macrophages).	UMLS:C0019618|SNOMEDCT_US:60657004|SNOMEDCT_US:65396000|MSH:D015614	hp.json		http://purl.obolibrary.org/obo/HP_0100727		
HP:0100728	biolink:PhenotypicFeature	Germ cell neoplasia		NCIT:C3708|UMLS:C4021985	hp.json		http://purl.obolibrary.org/obo/HP_0100728		
HP:0002170	biolink:PhenotypicFeature	Intracranial hemorrhage	Hemorrhage occurring within the skull.	SNOMEDCT_US:1386000|MSH:D020300|UMLS:C0151699	hp.json	Bleeding within the skull|Intracranial haemorrhage	http://purl.obolibrary.org/obo/HP_0002170		
HP:0100725	biolink:PhenotypicFeature	Lichenification	Thickening and hardening of the epidermis seen with exaggeration of normal skin lines.	SNOMEDCT_US:19940005|UMLS:C0023653|SNOMEDCT_US:402237006	hp.json		http://purl.obolibrary.org/obo/HP_0100725		
HP:0100726	biolink:PhenotypicFeature	Kaposi's sarcoma	A systemic disease which can present with cutaneous lesions with or without internal involvement. Tumors are caused by Human herpesvirus 8 (HHV8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV).	SNOMEDCT_US:109385007|UMLS:C0036220|MSH:D012514|SNOMEDCT_US:49937004	hp.json		http://purl.obolibrary.org/obo/HP_0100726		
HP:0002176	biolink:PhenotypicFeature	Spinal cord compression	External mechanical compression of the spinal cord.	MSH:D013117|SNOMEDCT_US:71286001|UMLS:C0037926	hp.json	Pressure on spinal cord	http://purl.obolibrary.org/obo/HP_0002176		
HP:0100723	biolink:PhenotypicFeature	Gastrointestinal stroma tumor		SNOMEDCT_US:128755003|MSH:D046152|SNOMEDCT_US:420120006|UMLS:C0238198	hp.json	Gastrointestinal stroma tumour|GI stroma tumor|Gastrointestinal stromal tumor|GIST|Gastrointestinal stromal tumours|Gastrointestinal stromal tumour|Gastrointestinal stromal tumors|GI stroma tumour	http://purl.obolibrary.org/obo/HP_0100723		
HP:0002173	biolink:PhenotypicFeature	Hypoglycemic seizures		UMLS:C0877056	hp.json		http://purl.obolibrary.org/obo/HP_0002173		
HP:0100724	biolink:PhenotypicFeature	Hypercoagulability	An abnormality of coagulation associated with an increased risk of thrombosis.	UMLS:C0398623|SNOMEDCT_US:234467004|MSH:D019851|SNOMEDCT_US:76612001	hp.json	Thrombophilia|Blood hyperviscosity	http://purl.obolibrary.org/obo/HP_0100724		
HP:0002174	biolink:PhenotypicFeature	Postural tremor	A type of tremors that is triggered by holding a limb in a fixed position.	MSH:D014202|UMLS:C0234378|SNOMEDCT_US:56610005	hp.json	Tremor, postural	http://purl.obolibrary.org/obo/HP_0002174		
HP:0100732	biolink:PhenotypicFeature	Pancreatic fibrosis		SNOMEDCT_US:25942009|UMLS:C0267952	hp.json		http://purl.obolibrary.org/obo/HP_0100732		
HP:0100733	biolink:PhenotypicFeature	Neoplasm of the parathyroid gland	A tumor (abnormal growth of tissue) of the parathyroid gland.	MSH:D010282|SNOMEDCT_US:127020005|NCIT:C3262|UMLS:C0030521	hp.json	Parathyroid neoplasia	http://purl.obolibrary.org/obo/HP_0100733		
HP:0100730	biolink:PhenotypicFeature	Bronchogenic cyst	A rare congenital cystic lesion of the lungs in the mediastinum.	SNOMEDCT_US:268194008|SNOMEDCT_US:9550003|MSH:D001994|UMLS:C0006281	hp.json		http://purl.obolibrary.org/obo/HP_0100730		
CHEBI:79209	biolink:ChemicalSubstance	alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide	A sialodiaosylceramide consisting of the trisaccharide alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose attached to the primary hydroxy function of a ceramide with undefined sphingoid base.	PMID:8643456|PMID:1601877	hp.json	ganglioside GM3	http://purl.obolibrary.org/obo/CHEBI_79209		3_STAR
HP:0100731	biolink:PhenotypicFeature	Transverse facial cleft	A horizontal cleft of the face, varying from slight widening of the mouth, to a cleft extending to the ear.	UMLS:C4020954	hp.json	Lateral facial cleft	http://purl.obolibrary.org/obo/HP_0100731		
HP:0002190	biolink:PhenotypicFeature	Choroid plexus cyst	A cyst occurring within the choroid plexus within a cerebral ventricle.	UMLS:C0338597|SNOMEDCT_US:230790004	hp.json		http://purl.obolibrary.org/obo/HP_0002190		
CHEBI:33847	biolink:ChemicalSubstance	monocyclic arene	A monocyclic aromatic hydrocarbon.		hp.json	monocyclic arenes	http://purl.obolibrary.org/obo/CHEBI_33847		3_STAR
HP:0002188	biolink:PhenotypicFeature	Delayed CNS myelination	Delayed myelination in the central nervous system.	UMLS:C4021758	hp.json	Delay in central nervous system myelination	http://purl.obolibrary.org/obo/HP_0002188		
HP:0002189	biolink:PhenotypicFeature	obsolete Excessive daytime sleepiness			hp.json		http://purl.obolibrary.org/obo/HP_0002189		
CHEBI:33842	biolink:ChemicalSubstance	aromatic annulene			hp.json	aromatic annulenes	http://purl.obolibrary.org/obo/CHEBI_33842		3_STAR
HP:0002183	biolink:PhenotypicFeature	Phonophobia	An abnormally heightened sensitivity to loud sounds.	MSH:D012001|UMLS:C0751466|SNOMEDCT_US:313387002	hp.json	Fear of loud sounds	http://purl.obolibrary.org/obo/HP_0002183		
HP:0002180	biolink:PhenotypicFeature	Neurodegeneration	Progressive loss of neural cells and tissue.	MSH:D009410|UMLS:C0524851|UMLS:C4020854|MSH:D019636|UMLS:C0027746	hp.json	Progressive neurodegenerative disorder|Neurodegenerative disease|Ongoing loss of nerve cells|Neuro-degenerative disease	http://purl.obolibrary.org/obo/HP_0002180		
HP:0100738	biolink:PhenotypicFeature	Abnormal eating behavior	Abnormal eating habit with excessive or insufficient consumption of food or any other abnormal pattern of food consumption.	UMLS:C4021982	hp.json	Abnormal eating behavior|Abnormal eating behaviour	http://purl.obolibrary.org/obo/HP_0100738		
HP:0002181	biolink:PhenotypicFeature	Cerebral edema	Abnormal accumulation of fluid in the brain.	MSH:D001929|UMLS:C0006114|UMLS:C1527311|SNOMEDCT_US:2032001	hp.json	Cerebral oedema|Brain swelling|Swelling of brain|Brain oedema|Brain edema	http://purl.obolibrary.org/obo/HP_0002181		
HP:0100739	biolink:PhenotypicFeature	Bulimia	A form of anomalous eating behavior characterized by binge eating is followed by self-induced vomiting or other compensatory behavior intended to prevent weight gain (purging, fasting or exercising or a combination of these).	UMLS:C0006370|MSH:D002032|SNOMEDCT_US:78004001	hp.json	Binge and purge	http://purl.obolibrary.org/obo/HP_0100739		
HP:0002186	biolink:PhenotypicFeature	Apraxia	A defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements.	UMLS:C0003635|MSH:D001072|SNOMEDCT_US:68345001|SNOMEDCT_US:6950007	hp.json	Apraxias	http://purl.obolibrary.org/obo/HP_0002186		
HP:0100736	biolink:PhenotypicFeature	Abnormal soft palate morphology	An abnormality of the soft palate.	UMLS:C4021984	hp.json	Abnormality of the muscular palate|Abnormality of the velum palatinum|Abnormality of the velum|Abnormality of the soft palate	http://purl.obolibrary.org/obo/HP_0100736		
HP:0100737	biolink:PhenotypicFeature	Abnormal hard palate morphology		UMLS:C4021983	hp.json	Abnormality of the hard palate|Abnormality of the secondary palate	http://purl.obolibrary.org/obo/HP_0100737		
HP:0002187	biolink:PhenotypicFeature	Intellectual disability, profound	Profound mental retardation is defined as an intelligence quotient (IQ) below 20.	UMLS:C0020796|MSH:D008607|SNOMEDCT_US:31216003|UMLS:C3161330	hp.json	Profound mental retardation|IQ less than 20|Mental retardation, profound	http://purl.obolibrary.org/obo/HP_0002187		
HP:0100734	biolink:PhenotypicFeature	Abnormality of vertebral epiphysis morphology	An anomaly of one or more epiphyses of one or more vertebrae.	UMLS:C4020953	hp.json	Abnormal shape of the end part of the vertebra bone|Abnormality of the vertebral epiphyses	http://purl.obolibrary.org/obo/HP_0100734		
HP:0002185	biolink:PhenotypicFeature	Neurofibrillary tangles	Pathological protein aggregates formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate in an insoluble form.	MSH:D016874|SNOMEDCT_US:85775002|UMLS:C0085400	hp.json	Neurofibrillary tangles composed of disordered microtubules in neurons|Paired helical filaments	http://purl.obolibrary.org/obo/HP_0002185		
HP:0100735	biolink:PhenotypicFeature	Hypertensive crisis		UMLS:C0020546|SNOMEDCT_US:706882009	hp.json		http://purl.obolibrary.org/obo/HP_0100735		
HP:0100743	biolink:PhenotypicFeature	Neoplasm of the rectum		NCIT:C3262|MSH:D012004|SNOMEDCT_US:126847008|UMLS:C0034885	hp.json	Rectal tumor|Rectal tumour	http://purl.obolibrary.org/obo/HP_0100743		
HP:0100744	biolink:PhenotypicFeature	Abnormality of the humeroradial joint		UMLS:C4021981	hp.json		http://purl.obolibrary.org/obo/HP_0100744		
HP:0100742	biolink:PhenotypicFeature	Vascular neoplasm	A benign or malignant neoplasm (tumour) originating in the vascular system.	UMLS:C0282607|NCIT:C3262|MSH:D019043|MSH:D009383|SNOMEDCT_US:699605009|SNOMEDCT_US:115235003|SNOMEDCT_US:126736007|UMLS:C0027668	hp.json	Blood vessel tumor|Blood vessel tumour	http://purl.obolibrary.org/obo/HP_0100742		
HP:0002157	biolink:PhenotypicFeature	Azotemia	An increased concentration of nitrogen compounds in the blood.	UMLS:C0242528|MSH:D053099|SNOMEDCT_US:445009001	hp.json	Azotaemia	http://purl.obolibrary.org/obo/HP_0002157		
HP:0002155	biolink:PhenotypicFeature	Hypertriglyceridemia	An abnormal increase in the level of triglycerides in the blood.	UMLS:C1522137	hp.json	Increased serum triglycerides|Increased circulating Tg levels|Increased triglycerides|Increased plasma triglycerides|Increased plasma Tg levels	http://purl.obolibrary.org/obo/HP_0002155		
HP:0002156	biolink:PhenotypicFeature	Homocystinuria	An increased concentration of homocystine in the urine.	UMLS:C0019880|MSH:D006712|SNOMEDCT_US:11282001	hp.json	High urine homocystine levels	http://purl.obolibrary.org/obo/HP_0002156		
CHEBI:79210	biolink:ChemicalSubstance	alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(1-)	An anionic ganglioside that is the conjugate base of alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3.	PMID:8643456|PMID:1601877	hp.json	ganglioside GM3(1-)|ganglioside GM3	http://purl.obolibrary.org/obo/CHEBI_79210		3_STAR
HP:0002159	biolink:PhenotypicFeature	Heparan sulfate excretion in urine	An increased concentration of heparan sulfates in the urine.	UMLS:C1854827	hp.json	Heparan sulphate excretion in urine	http://purl.obolibrary.org/obo/HP_0002159		
HP:0002150	biolink:PhenotypicFeature	Hypercalciuria		UMLS:C0020438|SNOMEDCT_US:71938000|MSH:D053565	hp.json	Elevated urine calcium levels|Hypercalcinuria	http://purl.obolibrary.org/obo/HP_0002150		
HP:0100749	biolink:PhenotypicFeature	Chest pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.	SNOMEDCT_US:29857009|MSH:D002637|UMLS:C0008031	hp.json	Chest pain|Chest discomfort|Thoracic pain	http://purl.obolibrary.org/obo/HP_0100749		
HP:0002153	biolink:PhenotypicFeature	Hyperkalemia	An abnormally increased potassium concentration in the blood.	MSH:D006947|UMLS:C0020461|SNOMEDCT_US:166689004|SNOMEDCT_US:238142003|SNOMEDCT_US:14140009	hp.json	Elevated serum potassium levels	http://purl.obolibrary.org/obo/HP_0002153		
HP:0100747	biolink:PhenotypicFeature	Macrodactyly of toe	A type of Macrodactyly affecting one or several toes.	UMLS:C2931596|MSH:C537719	hp.json	Foot macrodactyly	http://purl.obolibrary.org/obo/HP_0100747		
HP:0002154	biolink:PhenotypicFeature	Hyperglycinemia	An elevated concentration of glycine in the blood.	SNOMEDCT_US:64654004|UMLS:C0268559	hp.json	Elevated blood glycine levels|Hyperglycinaemia	http://purl.obolibrary.org/obo/HP_0002154		
CHEBI:18211	biolink:ChemicalSubstance	citrulline	The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the N(5)-position.	PMID:17513438|Wikipedia:Citrulline|PMID:18440672|PMID:11094453|PMID:11113071|PMID:11696417|PMID:21129371|CAS:627-77-0|Beilstein:2328251|PMID:17005970|PMID:17558653|PMID:18437289|PMID:16082501|PMID:17693747|PMID:18989563|CAS:627-77-0|Beilstein:1725417|Reaxys:1725417|PMID:19144577|PMID:16708633|PMID:21482070|PMID:1378088	hp.json	DL-2-amino-5-ureidovaleric acid|2-Amino-5-uredovaleric acid|dl-citrulline|2-amino-5-(carbamoylamino)pentanoic acid|Citrulline|N(5)-(aminocarbonyl)ornithine|N(5)-(aminocarbonyl)-DL-ornithine|N(5)-carbamoylornithine|Citrullin|N(5)-carbamoyl-DL-ornithine|citrulline|citrulina|Cit	http://purl.obolibrary.org/obo/CHEBI_18211		3_STAR
HP:0100748	biolink:PhenotypicFeature	Muscular edema		UMLS:C4021979	hp.json	Muscular oedema	http://purl.obolibrary.org/obo/HP_0100748		
HP:0002151	biolink:PhenotypicFeature	Increased serum lactate	Abnormally increased level of blood lactate (2-hydroxypropanoic acid). Lactate is produced from pyruvate by lactate dehydrogenase during normal metabolism. The terms lactate and lactic acid are often used interchangeably but lactate (the component measured in blood) is strictly a weak base whereas lactic acid is the corresponding acid. Lactic acidosis is often used clinically to describe elevated lactate but should be reserved for cases where there is a corresponding acidosis (pH below 7.35).	UMLS:C1836440	hp.json	Higher than normal levels of lactate in blood|Increased blood lactate	http://purl.obolibrary.org/obo/HP_0002151		
HP:0100745	biolink:PhenotypicFeature	Abnormality of the humeroulnar joint	An anomaly of the joint between the trochlear notch of ulna and the trochlea of humerus, which is part of the elbow joint.	UMLS:C4021980	hp.json		http://purl.obolibrary.org/obo/HP_0100745		
HP:0100746	biolink:PhenotypicFeature	Macrodactyly of finger	A type of Macrodactyly affecting one or several fingers.	MSH:C537720|UMLS:C0574044|SNOMEDCT_US:297195000	hp.json	Macrodactyly of hands	http://purl.obolibrary.org/obo/HP_0100746		
HP:0002152	biolink:PhenotypicFeature	Hyperproteinemia	An increased concentration of proteins in the blood.	UMLS:C0267988|SNOMEDCT_US:37064009	hp.json		http://purl.obolibrary.org/obo/HP_0002152		
HP:0100754	biolink:PhenotypicFeature	Mania	A state of abnormally elevated or irritable mood, arousal, and or energy levels.	UMLS:C0338831|MSH:D001714|SNOMEDCT_US:231494001	hp.json	Manic	http://purl.obolibrary.org/obo/HP_0100754		
HP:0100755	biolink:PhenotypicFeature	Abnormality of salivation		UMLS:C4021978	hp.json	Abnormal spit|Abnormality of salivation	http://purl.obolibrary.org/obo/HP_0100755		
HP:0100752	biolink:PhenotypicFeature	Abnormal liver lobulation	Formation of abnormal lobules (small masses of tissue) in the liver.	SNOMEDCT_US:253811003|UMLS:C0345286	hp.json	Hepatic anomalous lobulation|Anomalous liver lobulation	http://purl.obolibrary.org/obo/HP_0100752		
HP:0100753	biolink:PhenotypicFeature	Schizophrenia	A mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social or occupational dysfunction. The onset of symptoms typically occurs in young adulthood, with a global lifetime prevalence of about 0.3-0.7%.	UMLS:C0036341|MSH:D012559|SNOMEDCT_US:191526005|SNOMEDCT_US:58214004	hp.json		http://purl.obolibrary.org/obo/HP_0100753		
HP:0100750	biolink:PhenotypicFeature	Atelectasis	Collapse of part of a lung associated with absence of inflation (air) of that part.	UMLS:C0004144|SNOMEDCT_US:46621007|MSH:D001261	hp.json	Partial or complete collapse of part or entire lung|Pulmonary atelectasis	http://purl.obolibrary.org/obo/HP_0100750		
HP:0100751	biolink:PhenotypicFeature	Esophageal neoplasm	A tumor (abnormal growth of tissue) of the esophagus.	MSH:D004938|NCIT:C3262|UMLS:C0014859|SNOMEDCT_US:126817006	hp.json	Esophageal tumour|Esophageal tumor	http://purl.obolibrary.org/obo/HP_0100751		
NBO:0000886	biolink:NamedThing	increased amount of liquid in drinking regulation			hp.json		http://purl.obolibrary.org/obo/NBO_0000886		
CHEBI:33822	biolink:ChemicalSubstance	organic hydroxy compound	An organic compound having at least one hydroxy group attached to a carbon atom.		hp.json	hydroxy compounds|organic alcohol|organic hydroxy compounds	http://purl.obolibrary.org/obo/CHEBI_33822		3_STAR
HP:0002168	biolink:PhenotypicFeature	Scanning speech	An abnormal pattern of speech in which the words are as if measured or scanned; there is a pause after every syllable, and the syllables themselves are pronounced slowly.	UMLS:C0278184|SNOMEDCT_US:102935005|SNOMEDCT_US:77420001|UMLS:C0522198	hp.json	Explosive speech	http://purl.obolibrary.org/obo/HP_0002168		
HP:0002169	biolink:PhenotypicFeature	Clonus	A series of rhythmic and involuntary muscle contractions (at a frequency of about 5 to 7 Hz) that occur in response to an abruptly applied and sustained stretch.	UMLS:C0009024|SNOMEDCT_US:36649002	hp.json	Involuntary rhythmic muscular contractions and relaxations	http://purl.obolibrary.org/obo/HP_0002169		
HP:0002166	biolink:PhenotypicFeature	Impaired vibration sensation in the lower limbs	A decrease in the ability to perceive vibration in the legs.	UMLS:C1849134	hp.json	Diminished vibratory sensation in the legs|Impaired vibration sensation in the lower limbs|Decreased lower limb vibratory sense|Distal vibratory impairment of the lower limbs|Decreased vibratory sense in the lower extremities|Decreased vibratory sense in the lower limbs|Decreased vibratory sense in lower limbs|Distal sensory loss, especially vibratory sense	http://purl.obolibrary.org/obo/HP_0002166		
HP:0002167	biolink:PhenotypicFeature	Neurological speech impairment		UMLS:C0037822|MSH:D013064	hp.json	Speech impediment|Speech impairment|Speech disorder	http://purl.obolibrary.org/obo/HP_0002167		
HP:0002160	biolink:PhenotypicFeature	Hyperhomocystinemia	An increased concentration of homocystine in the blood.	UMLS:C3806347	hp.json	Elevated blood homocystine|Homocystinemia	http://purl.obolibrary.org/obo/HP_0002160		
HP:0002161	biolink:PhenotypicFeature	Hyperlysinemia	An increased concentration of lysine in the blood.	UMLS:C0268553|SNOMEDCT_US:58558003|MSH:D020167	hp.json	Elevated blood lysine	http://purl.obolibrary.org/obo/HP_0002161		
HP:0100758	biolink:PhenotypicFeature	Gangrene	A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis).	SNOMEDCT_US:36024000|SNOMEDCT_US:372070002|UMLS:C0017086|MSH:D005734	hp.json	Death of body tissue due to lack of blood flow or infection	http://purl.obolibrary.org/obo/HP_0100758		
HP:0002164	biolink:PhenotypicFeature	Nail dysplasia	The presence of developmental dysplasia of the nail.	UMLS:C1834405	hp.json	Dysplastic nails|Atypical nail growth|Onychodysplasia	http://purl.obolibrary.org/obo/HP_0002164		
HP:0100759	biolink:PhenotypicFeature	Clubbing of fingers	Terminal broadening of the fingers (distal phalanges of the fingers).	SNOMEDCT_US:30760008|UMLS:C0009080|MSH:D010005|MEDDRA:10016680	hp.json	Clubbed fingers|Clubbing (hands)|Finger clubbing|Clubbing of fingers	http://purl.obolibrary.org/obo/HP_0100759		hposlim_core
HP:0002165	biolink:PhenotypicFeature	Pterygium of nails	Inward advance of skin over the nail plate.	SNOMEDCT_US:110987009|UMLS:C0406438	hp.json	Nail pterygium	http://purl.obolibrary.org/obo/HP_0002165		
HP:0002162	biolink:PhenotypicFeature	Low posterior hairline	Hair on the neck extends more inferiorly than usual.	UMLS:C1855728	hp.json	Low posterior hair line|Low hairline at back of neck	http://purl.obolibrary.org/obo/HP_0002162		hposlim_core
HP:0100757	biolink:PhenotypicFeature	Pancreatoblastoma	A rare pediatric carcinoma of the pancreas.	UMLS:C0334489|SNOMEDCT_US:53618008|MSH:C537162	hp.json		http://purl.obolibrary.org/obo/HP_0100757		
HP:0004717	biolink:PhenotypicFeature	Axial malrotation of the kidney	An abnormality of the normal developmental rotation of the kidney leading to an abnormal axial orientation of the kidney.	UMLS:C4025300	hp.json		http://purl.obolibrary.org/obo/HP_0004717		
HP:0004719	biolink:PhenotypicFeature	Hyperechogenic kidneys	An increase in amplitude of waves returned in ultrasonography of the kidney, which is generally displayed as increased brightness of the signal.	UMLS:C3275899	hp.json	Increased echogenicity of the renal parenchyma|Echogenic kidneys	http://purl.obolibrary.org/obo/HP_0004719		
HP:0004713	biolink:PhenotypicFeature	Reversible renal failure	Acute renal failure with resolution of manifestations.	UMLS:C1843276	hp.json	Reversible renal failure|Reversible kidney failure	http://purl.obolibrary.org/obo/HP_0004713		
HP:0004712	biolink:PhenotypicFeature	Renal malrotation	An abnormality of the normal developmental rotation of the kidney leading to an abnormal orientation of the kidney.	SNOMEDCT_US:49008000|UMLS:C0238210	hp.json	Abnormal rotation of the kidneys|Malrotation of the kidney	http://purl.obolibrary.org/obo/HP_0004712		
HP:0004729	biolink:PhenotypicFeature	Acute tubulointerstitial nephritis	Acute inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.	UMLS:C1843274|MSH:C564356	hp.json		http://purl.obolibrary.org/obo/HP_0004729		
HP:0004727	biolink:PhenotypicFeature	Impaired renal concentrating ability	A defect in the ability to concentrate the urine.	UMLS:C1859819	hp.json	Urine concentration defect|Urine concentrating defect	http://purl.obolibrary.org/obo/HP_0004727		
HP:0004724	biolink:PhenotypicFeature	Calcium nephrolithiasis	The presence of calcium-containing calculi (stones) in the kidneys.	UMLS:C1855801	hp.json	Ca nephrolithiasis|Ca kidney stone|Calcium kidney stone|Ca2+ nephrolithiasis|Ca2+ kidney stone	http://purl.obolibrary.org/obo/HP_0004724		
HP:0004722	biolink:PhenotypicFeature	Thickened glomerular basement membrane	Prominent glomerular basement membrane (GBM), reflecting an increase in thickness (subjective estimate) of the basal lamina of the glomerulus of the kidney.	UMLS:C0445347|SNOMEDCT_US:264932002	hp.json		http://purl.obolibrary.org/obo/HP_0004722		
HP:0004704	biolink:PhenotypicFeature	Short fifth metatarsal	Short (hypoplastic) fifth metatarsal bone.	UMLS:C4021649	hp.json	Hypoplasia of the fifth metatarsal bone|Short 5th long bone of foot	http://purl.obolibrary.org/obo/HP_0004704		
CHEBI:43254	biolink:ChemicalSubstance	(4S)-4-hydroxy-3,4-dihydropyrimidin-2(1H)-one			hp.json		http://purl.obolibrary.org/obo/CHEBI_43254		1_STAR
CHEBI:18282	biolink:ChemicalSubstance	nucleobase	That part of DNA or RNA that may be involved in pairing.	KEGG:C00701|Wikipedia:Nucleobase	hp.json	Base|nucleobases	http://purl.obolibrary.org/obo/CHEBI_18282		3_STAR
HP:0004759	biolink:PhenotypicFeature	obsolete Nodular calcific aortic valve disease			hp.json		http://purl.obolibrary.org/obo/HP_0004759		
HP:0004754	biolink:PhenotypicFeature	Permanent atrial fibrillation	Atrial fibrillation (AF) that cannot be successfully terminated by cardioversion, and longstanding (more than 1 year) AF, where cardioversion is not indicated or has not been attempted, is termed permanent.	SNOMEDCT_US:426749004|SNOMEDCT_US:440028005|UMLS:C2586056|UMLS:C0694539	hp.json	Chronic atrial fibrillation	http://purl.obolibrary.org/obo/HP_0004754		
PATO:0000161	biolink:NamedThing	rate	A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time.		hp.json		http://purl.obolibrary.org/obo/PATO_0000161		scalar_slim|attribute_slim
HP:0004752	biolink:PhenotypicFeature	Congenital atrioventricular dissociation	A form of atrioventricular (AV) dissociation (i.e., the atria and the ventricles are under the control of two separate pacemakers) with congenital onset.	UMLS:C4025299	hp.json		http://purl.obolibrary.org/obo/HP_0004752		
HP:0004751	biolink:PhenotypicFeature	Paroxysmal ventricular tachycardia	Episodes of ventricular tachycardia that have a sudden onset and ending.	UMLS:C0030591|SNOMEDCT_US:66657009	hp.json	Episodes of ventricular tachycardia	http://purl.obolibrary.org/obo/HP_0004751		
HP:0004758	biolink:PhenotypicFeature	Effort-induced polymorphic ventricular tachycardia	Polymorphic ventricular arrhythmias of varying morphologythat do not exist under resting conditions but appear only upon physical exercise or catecholamine administration.	UMLS:C4025298	hp.json	Exercise-induced polymorphic ventricular tachycardia|Catecholaminergic polymorphic ventricular tachycardia	http://purl.obolibrary.org/obo/HP_0004758		
HP:0004757	biolink:PhenotypicFeature	Paroxysmal atrial fibrillation	Episodes of atrial fibrillation that typically last for several hours up to one day and terminate spontaneously.	SNOMEDCT_US:282825002|MSH:D001281|UMLS:C0235480	hp.json	Intermittent atrial fibrillation|Paroxysmal AF|Atrial fibrillation, paroxysmal	http://purl.obolibrary.org/obo/HP_0004757		
HP:0004756	biolink:PhenotypicFeature	Ventricular tachycardia	A tachycardia originating in the ventricles characterized by rapid heart rate (over 100 beats per minute) and broad QRS complexes (over 120 ms).	Fyler:7160|SNOMEDCT_US:25569003|UMLS:C0042514|MSH:D017180	hp.json		http://purl.obolibrary.org/obo/HP_0004756		
HP:0004755	biolink:PhenotypicFeature	Supraventricular tachycardia	Supraventricular tachycardia (SVT) is an abnormally increased heart rate (over 100 beats per minute at rest) with origin above the level of the ventricles.	MSH:D013617|SNOMEDCT_US:6456007|UMLS:C1698480|UMLS:C0039240	hp.json	SVT|Supraventricular tachyarrhythmia	http://purl.obolibrary.org/obo/HP_0004755		
CHEBI:57887	biolink:ChemicalSubstance	tryptaminium	An  ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3.	Gmelin:533978	hp.json	2-(1H-indol-3-yl)ethanaminium|tryptaminium(1+)|tryptamine|tryptaminium cation	http://purl.obolibrary.org/obo/CHEBI_57887		3_STAR
HP:0002108	biolink:PhenotypicFeature	Spontaneous pneumothorax	Pneumothorax occurring without traumatic injury to the chest or lung.	MSH:D011030|UMLS:C0149781|SNOMEDCT_US:80423007	hp.json	Spontaneous collapsed lung	http://purl.obolibrary.org/obo/HP_0002108		
HP:0002109	biolink:PhenotypicFeature	obsolete Abnormality of the bronchi			hp.json		http://purl.obolibrary.org/obo/HP_0002109		
HP:0002102	biolink:PhenotypicFeature	Pleuritis	Inflammation of the pleura.	UMLS:C0032231|MSH:D010998|SNOMEDCT_US:196075003	hp.json	Pleurisy|Inflammation of tissues lining lungs and chest	http://purl.obolibrary.org/obo/HP_0002102		
HP:0004764	biolink:PhenotypicFeature	Myxomatous mitral valve degeneration	Myxomatous mitral valve is defined as the presence of excess leaflet tissue and leaflet thickening greater than 5 mm, resulting in a prolapse greater than 2 mm into the left atrium on parasternal long axis view.	SNOMEDCT_US:42069006|SNOMEDCT_US:253395003|UMLS:C0264885	hp.json		http://purl.obolibrary.org/obo/HP_0004764		
HP:0002103	biolink:PhenotypicFeature	Abnormal pleura morphology	An abnormality of the pulmonary pleura, the thin, transparent membrane which covers the lungs and lines the inside of the chest walls.	UMLS:C4025726	hp.json	Abnormality of the pleura	http://purl.obolibrary.org/obo/HP_0002103		
HP:0002100	biolink:PhenotypicFeature	Recurrent aspiration pneumonia	Increased susceptibility to aspiration pneumonia, defined as pneumonia due to breathing in foreign material, as manifested by a medical history of repeated episodes of aspiration pneumonia.	UMLS:C0747651|SNOMEDCT_US:430969000	hp.json	Recurrent pneumonia due to aspiration,	http://purl.obolibrary.org/obo/HP_0002100		
HP:0004763	biolink:PhenotypicFeature	Paroxysmal supraventricular tachycardia	An episodic form of supraventricular tachycardia with abrupt onset and termination.	UMLS:C0030590|UMLS:C4280507|SNOMEDCT_US:67198005	hp.json	Episodic supraventricular tachycardia|Episodic rapid heart beat	http://purl.obolibrary.org/obo/HP_0004763		
HP:0004762	biolink:PhenotypicFeature	Hypoplasia of right ventricle	Underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells.	Fyler:1821|UMLS:C4082954	hp.json	Small right heart chamber|Underdeveloped right heart chamber|Heart right ventricle hypoplasia	http://purl.obolibrary.org/obo/HP_0004762		
HP:0002101	biolink:PhenotypicFeature	Abnormal lung lobation	A developmental defect in the formation of pulmonary lobes.	UMLS:C0685695|SNOMEDCT_US:91842005	hp.json	Defective lung lobation|Lung segmentation defects	http://purl.obolibrary.org/obo/HP_0002101		
HP:0002107	biolink:PhenotypicFeature	Pneumothorax	Accumulation of air in the pleural cavity leading to a partially or completely collapsed lung.	MSH:D011030|SNOMEDCT_US:36118008|UMLS:C0032326	hp.json	Collapsed lung	http://purl.obolibrary.org/obo/HP_0002107		
HP:0004768	biolink:PhenotypicFeature	Sparse anterior scalp hair	Decreased number of head hairs per unit area on the anterior region of the scalp.	UMLS:C1866246	hp.json	Thin scalp hair at front of head|Sparse scalp hair at front of head	http://purl.obolibrary.org/obo/HP_0004768		
HP:0002104	biolink:PhenotypicFeature	Apnea	Lack of breathing with no movement of the respiratory muscles and no exchange of air in the lungs. This term refers to a disposition to have recurrent episodes of apnea rather than to a single event.	UMLS:C0003578|SNOMEDCT_US:1023001|SNOMEDCT_US:248583008|MSH:D001049	hp.json	Apnoea|Apneic episodes|Absence of spontaneous respiration	http://purl.obolibrary.org/obo/HP_0002104		
HP:0002105	biolink:PhenotypicFeature	Hemoptysis	Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs.	MSH:D006469|SNOMEDCT_US:66857006|UMLS:C0019079|SNOMEDCT_US:6686005	hp.json	Haemoptysis|Coughing up blood|Coughing up blood or blood-stained mucus	http://purl.obolibrary.org/obo/HP_0002105		
HP:0004761	biolink:PhenotypicFeature	Post-angioplasty coronary artery restenosis		UMLS:C2676505	hp.json		http://purl.obolibrary.org/obo/HP_0004761		
HP:0004760	biolink:PhenotypicFeature	obsolete Congenital septal defect			hp.json		http://purl.obolibrary.org/obo/HP_0004760		
HP:0004737	biolink:PhenotypicFeature	Global glomerulosclerosis	Obliteration of the glomerular capillary lumen by increased collagenous matrix, with or without hyalinosis or foam cells. Sclerosis involves 100% of the glomerular tuft. Relative to other patent glomeruli in the sample, glomerular size is preserved, or increased/decreased by no more than 50%.	UMLS:C1865276	hp.json		http://purl.obolibrary.org/obo/HP_0004737		
HP:0004732	biolink:PhenotypicFeature	Impaired renal uric acid clearance	A reduction in the ability of the kidneys to remove uric acid from the serum.	UMLS:C1969371	hp.json		http://purl.obolibrary.org/obo/HP_0004732		
CHEBI:33892	biolink:ChemicalSubstance	iron coordination entity			hp.json	iron coordination entities|iron coordination compounds|iron coordination entity	http://purl.obolibrary.org/obo/CHEBI_33892		3_STAR
CHEBI:33893	biolink:ChemicalSubstance	reagent	A substance used in a chemical reaction to detect, measure, examine, or produce other substances.		hp.json	reactif|reactivo|reagent|reagents	http://purl.obolibrary.org/obo/CHEBI_33893		3_STAR
HP:0004736	biolink:PhenotypicFeature	Crossed fused renal ectopia	A developmental anomaly in which the kidneys are fused and localized on the same side of the midline. This anomaly is thought to result from disruption of the normal embryologic migration of the kidneys.	UMLS:C1835796	hp.json	Crossed-fused renal ectopia|Ectopic kidney with fusion	http://purl.obolibrary.org/obo/HP_0004736		
PATO:0000186	biolink:NamedThing	behavioral quality	An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation.		hp.json	behavioural quality	http://purl.obolibrary.org/obo/PATO_0000186		
HP:0004734	biolink:PhenotypicFeature	Renal cortical microcysts	Cysts of microscopic size confined to the cortex of the kidney.	UMLS:C1865877	hp.json	Multiple renal cortical microcysts|Cortical microcysts|Multiple small renal cortical cysts	http://purl.obolibrary.org/obo/HP_0004734		
PATO:0000188	biolink:NamedThing	coordination	A behavioral quality inhering in a bearer by virtue of the bearer's having or lacking skillful and effective interaction of movement.		hp.json		http://purl.obolibrary.org/obo/PATO_0000188		scalar_slim|disposition_slim|attribute_slim
CHEBI:33890	biolink:ChemicalSubstance	cobalt coordination entity			hp.json	cobalt coordination entities|cobalt coordination entity|cobalt coordination compounds	http://purl.obolibrary.org/obo/CHEBI_33890		3_STAR
HP:0004749	biolink:PhenotypicFeature	Atrial flutter	A type of atrial arrhythmia characterized by atrial rates of between 240 and 400 beats per minute and some degree of atrioventricular node conduction block. Typically, the ventricular rate is half the atrial rate. In the EKG; atrial flutter waves are observed as sawtooth-like atrial activity. Pathophysiologically, atrial flutter is a form of atrial reentry in which there is a premature electrical impulse creates a self-propagating circuit.	UMLS:C0004239|MSH:D001282|SNOMEDCT_US:5370000	hp.json		http://purl.obolibrary.org/obo/HP_0004749		
HP:0004743	biolink:PhenotypicFeature	Chronic tubulointerstitial nephritis	Chronic inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.	UMLS:C0238304|SNOMEDCT_US:60926001	hp.json		http://purl.obolibrary.org/obo/HP_0004743		
HP:0004742	biolink:PhenotypicFeature	Abnormal renal collecting system morphology	An abnormality of the renal collecting system.	UMLS:C1851303	hp.json	Abnormal collecting system|Abnormality of the renal collecting system|Renal collecting system anomalies	http://purl.obolibrary.org/obo/HP_0004742		
HP:0004746	biolink:PhenotypicFeature	Glomerular subendothelial electron-dense deposits	Electron dense deposits at the glomerular basement membrane,	MSH:D015432|UMLS:C0268743|SNOMEDCT_US:59479006	hp.json	Dense deposit disease|Membranoproliferative glomerulonephritis type II	http://purl.obolibrary.org/obo/HP_0004746		
CHEBI:18287	biolink:ChemicalSubstance	L-fucose	Any form of fucose having L configuration.	CAS:2438-80-4|PMID:20877283	hp.json	L-fucose|6-deoxy-L-galactose|(-)-L-fucose|L-(-)-fucose|(-)-fucose|L-galactomethylose|L-Fuc	http://purl.obolibrary.org/obo/CHEBI_18287		3_STAR
PATO:0000125	biolink:NamedThing	mass	A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter.		hp.json		http://purl.obolibrary.org/obo/PATO_0000125		scalar_slim|relational_slim|attribute_slim
PATO:0000122	biolink:NamedThing	length	A 1-D extent quality which is equal to the distance between two points.		hp.json		http://purl.obolibrary.org/obo/PATO_0000122		scalar_slim|attribute_slim|mpath_slim
PATO:0000136	biolink:NamedThing	closure	A morphological quality pertaining to the degree to which an object contains an opening, aperture, orifice or vent.		hp.json		http://purl.obolibrary.org/obo/PATO_0000136		attribute_slim
PATO:0000133	biolink:NamedThing	orientation	A spatial quality inhering in a bearer by virtue of the bearer's placement which is defined by the angle between the bearer and an axis, or the angle between the bearer and another object.		hp.json	angle|angular magnitude|plane angle|amount of rotation|angular placement	http://purl.obolibrary.org/obo/PATO_0000133		relational_slim|attribute_slim
PATO:0000141	biolink:NamedThing	structure	A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form.		hp.json	conformation|relational structural quality	http://purl.obolibrary.org/obo/PATO_0000141		attribute_slim
PATO:0000140	biolink:NamedThing	position	A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity.		hp.json	relational spatial quality|location|placement	http://purl.obolibrary.org/obo/PATO_0000140		attribute_slim
GO:0030595	biolink:BiologicalProcess	leukocyte chemotaxis	The movement of a leukocyte in response to an external stimulus.		hp.json	immune cell chemotaxis|leucocyte chemotaxis	http://purl.obolibrary.org/obo/GO_0030595		
GO:0030593	biolink:BiologicalProcess	neutrophil chemotaxis	The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.		hp.json		http://purl.obolibrary.org/obo/GO_0030593		
PR:P22091	biolink:Protein	T-cell acute lymphocytic leukemia protein 1 homolog (mouse)	A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of mouse.	UniProtKB:P22091	hp.json	Stem cell protein (mouse)|Tal-1|Tal1|mTAL1|Scl|TAL-1 (mouse)	http://purl.obolibrary.org/obo/PR_P22091		
PATO:0000150	biolink:NamedThing	texture	A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics.		hp.json		http://purl.obolibrary.org/obo/PATO_0000150		attribute_slim
HP:0004916	biolink:PhenotypicFeature	Generalized distal tubular acidosis		UMLS:C4025275	hp.json	Generalised distal tubular acidosis	http://purl.obolibrary.org/obo/HP_0004916		
HP:0004915	biolink:PhenotypicFeature	Impairment of galactose metabolism	An impairment of galactose metabolism.	UMLS:C4021643	hp.json	Impaired galactose metabolism	http://purl.obolibrary.org/obo/HP_0004915		
HP:0004914	biolink:PhenotypicFeature	Recurrent infantile hypoglycemia	Recurrent episodes of decreased concentration of glucose in the blood occurring during the infantile period.	UMLS:C4021644	hp.json	Episodic infantile hypoglycemia|Recurrent low blood sugar in infant	http://purl.obolibrary.org/obo/HP_0004914		
HP:0004913	biolink:PhenotypicFeature	Intermittent lactic acidemia	An intermittent (discontinuous) form of lactic acidemia.	UMLS:C1844917	hp.json		http://purl.obolibrary.org/obo/HP_0004913		
HP:0004919	biolink:PhenotypicFeature	Galactose intolerance		SNOMEDCT_US:190745006|UMLS:C0016952|MSH:D005693|SNOMEDCT_US:190749000	hp.json		http://purl.obolibrary.org/obo/HP_0004919		
HP:0004918	biolink:PhenotypicFeature	Hyperchloremic metabolic acidosis	A form of metabolic acidosis with increased serum chloride levels.	UMLS:C1969073	hp.json	Non-gap acidosis	http://purl.obolibrary.org/obo/HP_0004918		
HP:0004912	biolink:PhenotypicFeature	Hypophosphatemic rickets		SNOMEDCT_US:66266003|MSH:D063730|UMLS:C1704375	hp.json		http://purl.obolibrary.org/obo/HP_0004912		
HP:0004911	biolink:PhenotypicFeature	Episodic metabolic acidosis	Repeated transient episodes of metabolic acidosis, that is, of the buildup of acid or depletion of base due to accumulation of metabolic acids.	UMLS:C1859516	hp.json	Recurrent episodes of acidosis	http://purl.obolibrary.org/obo/HP_0004911		
HP:0004910	biolink:PhenotypicFeature	Bicarbonate-wasting renal tubular acidosis		UMLS:C1858626	hp.json	HCO3-wasting renal tubular acidosis|Renal bicarbonate wasting	http://purl.obolibrary.org/obo/HP_0004910		
HP:0004927	biolink:PhenotypicFeature	Pulmonary artery dilatation	An abnormal widening of the diameter of the pulmonary artery.	SNOMEDCT_US:251047005|UMLS:C0428851	hp.json		http://purl.obolibrary.org/obo/HP_0004927		
HP:0004926	biolink:PhenotypicFeature	Orthostatic hypotension due to autonomic dysfunction		UMLS:C1868528	hp.json		http://purl.obolibrary.org/obo/HP_0004926		
HP:0004925	biolink:PhenotypicFeature	Chronic lactic acidosis	A chronic form of lactic acidemia.	UMLS:C1839437	hp.json		http://purl.obolibrary.org/obo/HP_0004925		
HP:0004924	biolink:PhenotypicFeature	Abnormal oral glucose tolerance	An abnormal resistance to glucose, i.e., a reduction in the ability to maintain glucose levels in the blood stream within normal limits following oral administration of glucose.	UMLS:C1847425	hp.json	Abnormal glucose oral tolerance test	http://purl.obolibrary.org/obo/HP_0004924		
HP:0004929	biolink:PhenotypicFeature	obsolete Coronary atherosclerosis			hp.json		http://purl.obolibrary.org/obo/HP_0004929		
HP:0004928	biolink:PhenotypicFeature	obsolete Peripheral arterial stenosis			hp.json		http://purl.obolibrary.org/obo/HP_0004928		
HP:0004923	biolink:PhenotypicFeature	Hyperphenylalaninemia	An increased concentration of L-phenylalanine in the blood.	UMLS:C0751435|SNOMEDCT_US:68528007|MSH:D010661	hp.json		http://purl.obolibrary.org/obo/HP_0004923		
RO:0002598	biolink:NamedThing	capable of positively regulating	Holds between c and p if and only if c is capable of some activity a, and a positively regulates p.		hp.json		http://purl.obolibrary.org/obo/RO_0002598		
HP:0004922	biolink:PhenotypicFeature	Atypical hyperphenylalaninemia		UMLS:C4025273	hp.json		http://purl.obolibrary.org/obo/HP_0004922		
HP:0004921	biolink:PhenotypicFeature	Abnormal magnesium concentration	An abnormality of magnesium ion homeostasis.	UMLS:C4020826|UMLS:C4025274	hp.json	Abnormal Mg concentration|Abnormality of magnesium homeostasis|Abnormal magnesium metabolism	http://purl.obolibrary.org/obo/HP_0004921		
HP:0004920	biolink:PhenotypicFeature	Phenylpyruvic acidemia		UMLS:C1849926	hp.json		http://purl.obolibrary.org/obo/HP_0004920		
RO:0002595	biolink:NamedThing	causal relation between material entity and a process	A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity.		hp.json		http://purl.obolibrary.org/obo/RO_0002595		
RO:0002596	biolink:NamedThing	capable of regulating	Holds between c and p if and only if c is capable of some activity a, and a regulates p.		hp.json		http://purl.obolibrary.org/obo/RO_0002596		
RO:0002597	biolink:NamedThing	capable of negatively regulating	Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p.		hp.json		http://purl.obolibrary.org/obo/RO_0002597		
RO:0002590	biolink:NamedThing	results_in_disassembly_of		RO:0002590	hp.json		http://purl.obolibrary.org/obo/RO_0002590		
RO:0002592	biolink:NamedThing	results in organization of	p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c	RO:0002592	hp.json		http://purl.obolibrary.org/obo/RO_0002592		
RO:0002588	biolink:NamedThing	results_in_assembly_of		RO:0002588	hp.json		http://purl.obolibrary.org/obo/RO_0002588		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
HP:0004905	biolink:PhenotypicFeature	Low levels of vitamin A	A reduced concentration of vitamin A.	UMLS:C0042842|SNOMEDCT_US:72000004|MSH:D014802	hp.json	Vitamin A deficiency	http://purl.obolibrary.org/obo/HP_0004905		
HP:0004904	biolink:PhenotypicFeature	Maturity-onset diabetes of the young	The term Maturity-onset diabetes of the young (MODY) was initially used for patients diagnosed with fasting hyperglycemia that could be treated without insulin for more than two years, where the initial diagnosis was made at a young age (under 25 years). Thus, MODY combines characteristics of type 1 diabetes (young age at diagnosis) and type 2 diabetes (less insulin dependence than type 1 diabetes). The term MODY is now most often used to refer to a group of monogenic diseases with these characteristics. Here, the term is used to describe hyperglycemia diagnosed at a young age with no or minor insulin dependency, no evidence of insulin resistence, and lack of evidence of autoimmune destruction of the beta cells.	SNOMEDCT_US:609561005|MSH:C562772|UMLS:C0342276	hp.json	Maturity onset diabetes of the young|MODY	http://purl.obolibrary.org/obo/HP_0004904		
RO:0002584	biolink:NamedThing	has part structure that is capable of	s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p		hp.json		http://purl.obolibrary.org/obo/RO_0002584		
HP:0004902	biolink:PhenotypicFeature	Congenital lactic acidosis	A form of lactic acidemia with congenital onset.	UMLS:C4025276	hp.json		http://purl.obolibrary.org/obo/HP_0004902		
RO:0002586	biolink:NamedThing	results in breakdown of	p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p		hp.json		http://purl.obolibrary.org/obo/RO_0002586		
HP:0004909	biolink:PhenotypicFeature	Hypokalemic hypochloremic metabolic alkalosis		UMLS:C0740896	hp.json		http://purl.obolibrary.org/obo/HP_0004909		
PATO:0000117	biolink:NamedThing	size	A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude.		hp.json		http://purl.obolibrary.org/obo/PATO_0000117		scalar_slim|attribute_slim
RO:0002581	biolink:NamedThing	is a defining property chain axiom	If R <- P o Q is a defining property chain axiom, then it also holds that R -> P o Q. Note that this cannot be expressed directly in OWL		hp.json		http://purl.obolibrary.org/obo/RO_0002581		
HP:0004906	biolink:PhenotypicFeature	Hypernatremic dehydration		UMLS:C1850544|SNOMEDCT_US:427784006	hp.json		http://purl.obolibrary.org/obo/HP_0004906		
CHEBI:43176	biolink:ChemicalSubstance	hydroxy group		PDBeChem:OH	hp.json	hydroxy|hydroxyl|hydroxyl group|HYDROXY GROUP|-OH|hydroxy group	http://purl.obolibrary.org/obo/CHEBI_43176		3_STAR
PATO:0000119	biolink:NamedThing	height	A 1-D extent quality inhering in a bearer by virtue of the bearer's vertical dimension of extension.		hp.json		http://purl.obolibrary.org/obo/PATO_0000119		scalar_slim|attribute_slim
RO:0002582	biolink:NamedThing	is a defining property chain axiom where second argument is reflexive	If R <- P o Q is a defining property chain axiom, then (1) R -> P o Q holds and (2) Q is either reflexive or locally reflexive. A corollary of this is that P SubPropertyOf R.		hp.json		http://purl.obolibrary.org/obo/RO_0002582		
RO:0002576	biolink:NamedThing	skeleton of	inverse of has skeleton	RO:0002576	hp.json		http://purl.obolibrary.org/obo/RO_0002576		http://purl.obolibrary.org/obo/RO_0002259
HP:0004901	biolink:PhenotypicFeature	Exercise-induced lactic acidemia	A form of lactic acidemia that occurs following exercise or exertion.	UMLS:C4025277	hp.json	Exercise-induced lactic acidosis	http://purl.obolibrary.org/obo/HP_0004901		
HP:0004900	biolink:PhenotypicFeature	Severe lactic acidosis	A severe form of lactic acidemia.	UMLS:C1839436	hp.json		http://purl.obolibrary.org/obo/HP_0004900		
RO:0002577	biolink:NamedThing	system	A material entity consisting of multiple components that are causally integrated.		hp.json		http://purl.obolibrary.org/obo/RO_0002577		
RO:0002578	biolink:NamedThing	directly regulates	Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.		hp.json		http://purl.obolibrary.org/obo/RO_0002578		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
HP:0100523	biolink:PhenotypicFeature	Liver abscess	The presence of an abscess of the liver.	SNOMEDCT_US:27916005|UMLS:C0023885|MSH:D008100	hp.json	Hepatic abscess|Liver abscess	http://purl.obolibrary.org/obo/HP_0100523		
HP:0100524	biolink:PhenotypicFeature	Limb duplication	Congenital duplication of all or part of a limb.	UMLS:C0265551|SNOMEDCT_US:34488005	hp.json	Dimelia|Limb duplication	http://purl.obolibrary.org/obo/HP_0100524		hposlim_core
HP:0100521	biolink:PhenotypicFeature	Neoplasm of the thymus	A tumor (abnormal growth of tissue) of the thymus.	MSH:D013953|SNOMEDCT_US:127231009|UMLS:C3714644|NCIT:C3262	hp.json		http://purl.obolibrary.org/obo/HP_0100521		
HP:0100522	biolink:PhenotypicFeature	Thymoma	A tumor originating from the epithelial cells of the thymus.	SNOMEDCT_US:444231005|UMLS:C0040100|SNOMEDCT_US:128856005|NCIT:C3411|MSH:D013945	hp.json		http://purl.obolibrary.org/obo/HP_0100522		
HP:0100520	biolink:PhenotypicFeature	Oliguria	Low output of urine, clinically classified as an output below 300-500ml/day.	MSH:D009846|SNOMEDCT_US:718403007|UMLS:C0028961|SNOMEDCT_US:83128009	hp.json		http://purl.obolibrary.org/obo/HP_0100520		
RO:0002572	biolink:NamedThing	luminal space of	s is luminal space of x iff s is lumen_of x and s is an immaterial entity	RO:0002572	hp.json		http://purl.obolibrary.org/obo/RO_0002572		ro-eco
RO:0002573	biolink:NamedThing	has modifier	A relation that holds between an attribute or a qualifier and another attribute.	RO:0002180	hp.json		http://purl.obolibrary.org/obo/RO_0002573		ro-eco
RO:0002571	biolink:NamedThing	lumen of	x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.	RO:0002571	hp.json		http://purl.obolibrary.org/obo/RO_0002571		ro-eco
RO:0002569	biolink:NamedThing	has branching part	inverse of branching part of	RO:0002569	hp.json		http://purl.obolibrary.org/obo/RO_0002569		ro-eco|http://purl.obolibrary.org/obo/RO_0002259
RO:0002565	biolink:NamedThing	results in movement of	Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c	RO:0002565	hp.json		http://purl.obolibrary.org/obo/RO_0002565		http://purl.obolibrary.org/obo/valid_for_go_ontology|http://purl.obolibrary.org/obo/valid_for_gocam|http://purl.obolibrary.org/obo/valid_for_go_annotation_extension
RO:0002566	biolink:NamedThing	causally influences	The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size).		hp.json		http://purl.obolibrary.org/obo/RO_0002566		
RO:0002567	biolink:NamedThing	biomechanically related to	A relation that holds between elements of a musculoskeletal system or its analogs.		hp.json		http://purl.obolibrary.org/obo/RO_0002567		
RO:0002568	biolink:NamedThing	has muscle antagonist	m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position.	RO:0002568	hp.json		http://purl.obolibrary.org/obo/RO_0002568		
HP:0100529	biolink:PhenotypicFeature	Abnormal blood phosphate concentration	An abnormality of phosphate homeostasis or concentration in the body.	UMLS:C4022032	hp.json	Abnormality of phosphate homeostasis	http://purl.obolibrary.org/obo/HP_0100529		
HP:0100527	biolink:PhenotypicFeature	Neoplasia of the pleura		NCIT:C3262|UMLS:C4022033	hp.json		http://purl.obolibrary.org/obo/HP_0100527		
HP:0100528	biolink:PhenotypicFeature	Pleuropulmonary blastoma	A rare cancer originating in the lung or pleural cavity that occurs most often in infants and young children but also has been reported in adults. Pleuropulmonary blastoma is regarded as malignant.	SNOMEDCT_US:707670009|SNOMEDCT_US:128763002|NCIT:C3732|MSH:C537516|UMLS:C1266144	hp.json		http://purl.obolibrary.org/obo/HP_0100528		
HP:0100525	biolink:PhenotypicFeature	Urachus fistula	Persistence of the urachal canal with drainage of urine from the bladder through the persistent allantois canal to the umbilicus.	SNOMEDCT_US:398320008|SNOMEDCT_US:50986000|UMLS:C0345344	hp.json		http://purl.obolibrary.org/obo/HP_0100525		
HP:0100526	biolink:PhenotypicFeature	Neoplasm of the lung	Tumor of the lung.	NCIT:C3262|MSH:D008175|SNOMEDCT_US:126713003|UMLS:C0024121	hp.json	Lung tumour|Lung cancer|Lung tumor	http://purl.obolibrary.org/obo/HP_0100526		
HP:0100534	biolink:PhenotypicFeature	Episcleritis	Inflammation of the episclera, a thin layer of tissue covering the white part (sclera) of the eye.	SNOMEDCT_US:815008|MSH:D015423|UMLS:C0014583	hp.json	Inflammation of the thin layer on top of the white part of eye	http://purl.obolibrary.org/obo/HP_0100534		hposlim_core
HP:0100535	biolink:PhenotypicFeature	Tibiofibular diastasis		UMLS:C4022029	hp.json		http://purl.obolibrary.org/obo/HP_0100535		
HP:0100532	biolink:PhenotypicFeature	Scleritis	Inflammation of the sclera.	UMLS:C0036416|SNOMEDCT_US:78370002|MSH:D015423	hp.json	Inflammation of the outer white part of the eye	http://purl.obolibrary.org/obo/HP_0100532		hposlim_core
CHEBI:67142	biolink:ChemicalSubstance	nucleobase analogue	A molecule that can substitute for a normal nucleobase in nucleic acids.	Wikipedia:Base_analog	hp.json	base analog|base analogue|nucleobase analogs|nucleobase analogues|nucleobase analog|base analogs|base analogues	http://purl.obolibrary.org/obo/CHEBI_67142		3_STAR
HP:0100533	biolink:PhenotypicFeature	Inflammatory abnormality of the eye	Inflammation of the eye, parts of the eye or the periorbital region.	UMLS:C4020969	hp.json	Ocular inflammation|Inflammatory abnormality of the eye	http://purl.obolibrary.org/obo/HP_0100533		
HP:0100530	biolink:PhenotypicFeature	Abnormal calcium-phosphate regulating hormone level	Any deviation from the normal concentration in the blood circulation of a hormone that is involved in the regulation of phosphate and calcium.	UMLS:C4022031	hp.json	Abnormal Ca-PHOS regulating hormone level|Abnormal Ca2+ PO4 regulating hormone level	http://purl.obolibrary.org/obo/HP_0100530		
HP:0100531	biolink:PhenotypicFeature	Wind-swept deformity of the knees	The appearance of abnormal valgus deformity in one knee in association with varus deformity in the other.	UMLS:C4022030	hp.json	Wind-swept deformity of the knees	http://purl.obolibrary.org/obo/HP_0100531		
RO:0002563	biolink:NamedThing	interaction relation helper property			hp.json		http://purl.obolibrary.org/obo/RO_0002563		
RO:0002564	biolink:NamedThing	molecular interaction relation helper property			hp.json		http://purl.obolibrary.org/obo/RO_0002564		
RO:0002559	biolink:NamedThing	causally influenced by			hp.json		http://purl.obolibrary.org/obo/RO_0002559		
HP:0100538	biolink:PhenotypicFeature	Abnormality of the supraorbital ridges	An anomaly of the supraorbital portion of the frontal bones.	UMLS:C4022027	hp.json	Abnormality of the brow of the face|Malformation of the supraorbital ridges|Deformity of the supraorbital ridges|Malformation of the supraorbital margins|Deformity of the supraorbital margins	http://purl.obolibrary.org/obo/HP_0100538		
HP:0100539	biolink:PhenotypicFeature	Periorbital edema	Edema affecting the region situated around the orbit of the eye.	SNOMEDCT_US:267041004|SNOMEDCT_US:109245003|UMLS:C0151205|UMLS:C0424810|SNOMEDCT_US:49563000|UMLS:C0149754	hp.json	Periorbital oedema|Periorbital cellulitis	http://purl.obolibrary.org/obo/HP_0100539		
HP:0100536	biolink:PhenotypicFeature	Abnormality of the fascia	An abnormality of fascia.	UMLS:C4022028	hp.json		http://purl.obolibrary.org/obo/HP_0100536		
HP:0100537	biolink:PhenotypicFeature	Fasciitis	Inflammation of fascia, the tissue under the skin and over the muscle.	SNOMEDCT_US:36948007|MSH:D005208|UMLS:C0015645	hp.json	Inflammation of the fascia	http://purl.obolibrary.org/obo/HP_0100537		
HP:0100545	biolink:PhenotypicFeature	Arterial stenosis	Narrowing or constriction of the inner surface (lumen) of an artery.	UMLS:C0038449|SNOMEDCT_US:68109007	hp.json	Narrowing of an artery	http://purl.obolibrary.org/obo/HP_0100545		
HP:0100546	biolink:PhenotypicFeature	Carotid artery stenosis	Narrowing of the carotid arteries.	UMLS:C0007282|MSH:D016893|SNOMEDCT_US:64586002	hp.json	Narrowing of carotid artery|Carotid stenosis	http://purl.obolibrary.org/obo/HP_0100546		
HP:0100543	biolink:PhenotypicFeature	Cognitive impairment	Abnormal cognition with deficits in thinking, reasoning, or remembering.	SNOMEDCT_US:386806002|MSH:D060825|UMLS:C0683322|UMLS:C0338656	hp.json	Cognitive impairment|Cognitive abnormality|Cognitive deficits|Intellectual impairment|Cognitive defects|Abnormality of cognition	http://purl.obolibrary.org/obo/HP_0100543		
HP:0100544	biolink:PhenotypicFeature	Neoplasm of the heart	A tumor (abnormal growth of tissue) of the heart.	MSH:D006338|SNOMEDCT_US:387842002|NCIT:C3262|UMLS:C0018809	hp.json	Heart tumor|Cardiac neoplasm|Heart tumour|Cardiac neoplasia	http://purl.obolibrary.org/obo/HP_0100544		
HP:0100541	biolink:PhenotypicFeature	Femoral hernia	A hernia which occurs just below the inguinal ligament, where abdominal contents pass through a naturally occurring weakness called the femoral canal.	SNOMEDCT_US:50063009|MEDDRA:10016434|MSH:D006550|UMLS:C0019288	hp.json	Crural hernia	http://purl.obolibrary.org/obo/HP_0100541		hposlim_core
HP:0100542	biolink:PhenotypicFeature	Abnormal localization of kidney	An abnormal site of the kidney.	UMLS:C4020968	hp.json	Abnormal localisation of kidneys	http://purl.obolibrary.org/obo/HP_0100542		
HP:0100540	biolink:PhenotypicFeature	Palpebral edema	Edema in the region of the eyelids.	UMLS:C0162285|SNOMEDCT_US:89091004	hp.json	Puffy lids|Edema of the eyelids|Swelling of eyelids|Oedema of the eyelids|Puffy eyelids|Fullness of eyelids|Eyelid oedema|Eyelid edema|Palpebral oedema	http://purl.obolibrary.org/obo/HP_0100540		
RO:0002551	biolink:NamedThing	has skeleton	A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision.	RO:0002551	hp.json	has supporting framework|has sekeletal support	http://purl.obolibrary.org/obo/RO_0002551		
HP:0100547	biolink:PhenotypicFeature	Abnormal forebrain morphology	An abnormality of the forebrain, which has as its parts the telencephalon, diencephalon, lateral ventricles and third ventricle.	UMLS:C4020967	hp.json	Abnormal shape of forebrain|Abnormality of forebrain morphology|Abnormality of the forebrain	http://purl.obolibrary.org/obo/HP_0100547		
HP:0100548	biolink:PhenotypicFeature	Exstrophy	Eversion of a hollow organ and exposure, inside out, and protruded through the abdominal wall.	SNOMEDCT_US:110407002|UMLS:C0015338	hp.json		http://purl.obolibrary.org/obo/HP_0100548		
HP:0100556	biolink:PhenotypicFeature	Hemiatrophy	Undergrowth of the limbs that affects only one side.	SNOMEDCT_US:34087007|UMLS:C0333662	hp.json	Asymmetric limb shortening|Hemiatrophy of the body	http://purl.obolibrary.org/obo/HP_0100556		
HP:0100557	biolink:PhenotypicFeature	Hemiatrophy of lower limb	Unilateral atrophy (reduction in size) of a leg.	SNOMEDCT_US:709411004|UMLS:C0431934	hp.json	Asymmetric lower limb shortening	http://purl.obolibrary.org/obo/HP_0100557		
HP:0100554	biolink:PhenotypicFeature	Hemihypertrophy of upper limb	Overgrowth of only one arm.	UMLS:C0431810|SNOMEDCT_US:253920006	hp.json	Overgrowth of one arm	http://purl.obolibrary.org/obo/HP_0100554		
HP:0100555	biolink:PhenotypicFeature	Asymmetric growth	A growth pattern that displays an abnormal difference between the left and the right side.	UMLS:C4022025	hp.json	Uneven or disproportionate growth of one body part compared to another	http://purl.obolibrary.org/obo/HP_0100555		
HP:0100552	biolink:PhenotypicFeature	Neoplasm of the tracheobronchial system		NCIT:C3262|UMLS:C4022026	hp.json		http://purl.obolibrary.org/obo/HP_0100552		
HP:0100553	biolink:PhenotypicFeature	Hemihypertrophy of lower limb	Overgrowth of only one leg.	UMLS:C0431928|SNOMEDCT_US:205369009	hp.json	Overgrowth of one leg	http://purl.obolibrary.org/obo/HP_0100553		
HP:0100550	biolink:PhenotypicFeature	Tendon rupture	Breakage (tear) of a tendon.	SNOMEDCT_US:415749005|UMLS:C0151937	hp.json	Tendon rupture|Tendon/muscle rupture|Rupture of tendons|Ruptured tendon	http://purl.obolibrary.org/obo/HP_0100550		
HP:0100551	biolink:PhenotypicFeature	Neoplasm of the trachea	A neoplasm of the trachea.	UMLS:C0040582|MSH:D014134|SNOMEDCT_US:126703006|NCIT:C3262	hp.json	Tracheal neoplasm	http://purl.obolibrary.org/obo/HP_0100551		
GO:0042552	biolink:BiologicalProcess	myelination	The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.	Wikipedia:Myelin	hp.json	myelinogenesis	http://purl.obolibrary.org/obo/GO_0042552		
GO:0042551	biolink:BiologicalProcess	neuron maturation	A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.		hp.json		http://purl.obolibrary.org/obo/GO_0042551		
UBERON:0006497	biolink:AnatomicalEntity	interosseous muscle of pes	Any of the interosseous muscles of the pes (foot). Includes the plantar and dorsal interossei.	NCIT:C53172|FMA:37456|MA:0002302|EMAPA:36262|UMLS:C0448494	hp.json	pes interosseous muscle|interosseous of foot|foot interosseous|interosseous muscle of foot|foot interosseus muscle	http://purl.obolibrary.org/obo/UBERON_0006497		
HP:0100558	biolink:PhenotypicFeature	Hemiatrophy of upper limb	Unilateral atrophy (reduction in size) of an arm.	SNOMEDCT_US:253921005|UMLS:C0431814	hp.json	Asymmetric upper limb shortening|Hemihypotrophy of upper limb	http://purl.obolibrary.org/obo/HP_0100558		
HP:0100559	biolink:PhenotypicFeature	Lower limb asymmetry	A difference in length or diameter between the left and right leg.	SNOMEDCT_US:45939007|UMLS:C0023221|MSH:D007870	hp.json	Left and right leg differ in length or width|Leg length discrepancy	http://purl.obolibrary.org/obo/HP_0100559		
HP:0100568	biolink:PhenotypicFeature	Neoplasm of the endocrine system	A tumor (abnormal growth of tissue) of the endocrine system.	SNOMEDCT_US:387922007|UMLS:C0014132|NCIT:C3262|MSH:D004701|SNOMEDCT_US:387927001	hp.json	Endocrine neoplasia	http://purl.obolibrary.org/obo/HP_0100568		
HP:0100565	biolink:PhenotypicFeature	Hydromyelia	Dilation of central canal from incomplete fusion of the posterior columns or persistence of the primitive large canal of the embryo.	SNOMEDCT_US:11197005|SNOMEDCT_US:74740003|UMLS:C0152444	hp.json		http://purl.obolibrary.org/obo/HP_0100565		
HP:0100566	biolink:PhenotypicFeature	Amyelia	Congenital absence of the spinal cord.	UMLS:C0266510|SNOMEDCT_US:78784005	hp.json	Absent spinal cord	http://purl.obolibrary.org/obo/HP_0100566		
HP:0100563	biolink:PhenotypicFeature	Diastomatomyelia	Coexistence of two hemicords, at variable levels, causing splaying of the posterior vertebral elements. Results in neurological deficits in lower limb or perineum.	UMLS:C4022023	hp.json		http://purl.obolibrary.org/obo/HP_0100563		
HP:0100564	biolink:PhenotypicFeature	Triplomyelia	Triplication of the spinal cord - extremely rare.	UMLS:C4022022	hp.json	Triplication of spinal cord	http://purl.obolibrary.org/obo/HP_0100564		
HP:0100561	biolink:PhenotypicFeature	Spinal cord lesion		UMLS:C0241224	hp.json		http://purl.obolibrary.org/obo/HP_0100561		
HP:0100562	biolink:PhenotypicFeature	Diplomyelia	Duplication of the spinal cord.	SNOMEDCT_US:360527003|UMLS:C1260890	hp.json	Duplication of spinal cord	http://purl.obolibrary.org/obo/HP_0100562		
HP:0100560	biolink:PhenotypicFeature	Upper limb asymmetry	Difference in length or size between the right and left arm.	UMLS:C4022024	hp.json	Unequal size of arms	http://purl.obolibrary.org/obo/HP_0100560		hposlim_core
GO:0042562	biolink:MolecularActivity	hormone binding	Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor.		hp.json		http://purl.obolibrary.org/obo/GO_0042562		goslim_chembl|goslim_pir
HP:0100569	biolink:PhenotypicFeature	Abnormally ossified vertebrae	An abnormality of the formation and mineralization of one or more vertebrae.	UMLS:C4020966	hp.json	Abnormality of ossification/mineralisation of vertebrae|Abnormal bone maturation of vertebra|Abnormal vertebral ossification	http://purl.obolibrary.org/obo/HP_0100569		
HP:0100578	biolink:PhenotypicFeature	Lipoatrophy	Localized loss of fat tissue.	UMLS:C1280433|MEDDRA:10024604|SNOMEDCT_US:248315005	hp.json	Loss of fat tissue in localised area|Atrophy of fat|Loss of fat tissue in localized area	http://purl.obolibrary.org/obo/HP_0100578		hposlim_core
HP:0100579	biolink:PhenotypicFeature	Mucosal telangiectasiae	Telangiectasia of the mucosa, the mucous membranes which are involved in absorption and secretion that line cavities that are exposed to the external environment and internal organs.	UMLS:C4022020	hp.json		http://purl.obolibrary.org/obo/HP_0100579		
HP:0100576	biolink:PhenotypicFeature	Amaurosis fugax	A transient visual disturbance that is typically caused by a circulatory, ocular or neurological underlying condition.	SNOMEDCT_US:88032003|MSH:D020757|UMLS:C0149793	hp.json		http://purl.obolibrary.org/obo/HP_0100576		hposlim_core
HP:0100577	biolink:PhenotypicFeature	Urinary bladder inflammation	Inflammation of the urinary bladder.	SNOMEDCT_US:38822007|UMLS:C0010692|MSH:D003556	hp.json	Urinary bladder inflammation|Cystitis of the urinary bladder	http://purl.obolibrary.org/obo/HP_0100577		
HP:0100574	biolink:PhenotypicFeature	Biliary tract neoplasm	A tumor (abnormal growth of tissue) of the biliary system.	NCIT:C3262|SNOMEDCT_US:126853008|UMLS:C4020709|MSH:D001661|UMLS:C0005426	hp.json	Neoplasia of the biliary tract	http://purl.obolibrary.org/obo/HP_0100574		
HP:0100575	biolink:PhenotypicFeature	Neoplasm of the gallbladder	The presence of a neoplasm of the gallbladder.	SNOMEDCT_US:126854002|NCIT:C3262|MSH:D005706|UMLS:C4020708|UMLS:C0016978	hp.json	Neoplasia of the gallbladder	http://purl.obolibrary.org/obo/HP_0100575		
HP:0100572	biolink:PhenotypicFeature	Fibrous cardiac diverticulum	A fibrous cardiac diverticulum refers to an aneurysm and usually appears as an isolated congenital anomaly.	UMLS:C4020964	hp.json	Congenital ventricular aneurysm	http://purl.obolibrary.org/obo/HP_0100572		
HP:0100573	biolink:PhenotypicFeature	Muscular cardiac diverticulum		UMLS:C4022021	hp.json		http://purl.obolibrary.org/obo/HP_0100573		
HP:0100570	biolink:PhenotypicFeature	Carcinoid tumor	A tumor formed from the endocrine (argentaffin) cells of the mucosal lining of a variety of organs including the stomach and intestine. These cells are from neuroectodermal origin.	SNOMEDCT_US:443492008|SNOMEDCT_US:189607006|UMLS:C0007095|MSH:D002276	hp.json	Carcinoid tumors|Carcinoid|Carcinoid tumours|Carcinoid tumour	http://purl.obolibrary.org/obo/HP_0100570		
HP:0100571	biolink:PhenotypicFeature	Cardiac diverticulum	A cardiac diverticulum is a rare congenital malformation which is either fibrous or muscular.	UMLS:C4020965	hp.json	Ventricular diverticulum	http://purl.obolibrary.org/obo/HP_0100571		
GO:0042571	biolink:CellularComponent	immunoglobulin complex, circulating	An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.	Wikipedia:Antibody	hp.json	antibody	http://purl.obolibrary.org/obo/GO_0042571		
GO:0042578	biolink:MolecularActivity	phosphoric ester hydrolase activity	Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.		hp.json		http://purl.obolibrary.org/obo/GO_0042578		
HP:0100589	biolink:PhenotypicFeature	Urogenital fistula	The presence of a fistula affecting the genitourinary system.	UMLS:C0853877	hp.json		http://purl.obolibrary.org/obo/HP_0100589		
HP:0100587	biolink:PhenotypicFeature	Abnormal preputium morphology	An abnormality of the retractable fold of skin that covers the tip of the penis.	UMLS:C4022016	hp.json	Abnormality of the preputium	http://purl.obolibrary.org/obo/HP_0100587		
HP:0100588	biolink:PhenotypicFeature	Paraphimosis	The foreskin becomes trapped behind the glans penis, and cannot be pulled back to its normal flaccid position covering the glans penis.	UMLS:C0030483|SNOMEDCT_US:13758004|MSH:D010263	hp.json		http://purl.obolibrary.org/obo/HP_0100588		
HP:0100585	biolink:PhenotypicFeature	Telangiectasia of the skin	Presence of small, permanently dilated blood vessels near the surface of the skin, visible as small focal red lesions.	UMLS:C4022018	hp.json	Teleangiectasia of the skin	http://purl.obolibrary.org/obo/HP_0100585		
HP:0100586	biolink:PhenotypicFeature	Sterile pyuria	Patients who routinely have greater than 20 leukocytes per microliter, but have abacterial urine, are said to have sterile pyuria.	UMLS:C4022017	hp.json	Aseptic leukocyturia	http://purl.obolibrary.org/obo/HP_0100586		
HP:0100583	biolink:PhenotypicFeature	Corneal perforation	A rupture of the cornea through which a portion of the iris protrudes.	UMLS:C0948060|SNOMEDCT_US:74895004|MSH:D057112|UMLS:C0339293	hp.json	Iridocele	http://purl.obolibrary.org/obo/HP_0100583		
HP:0100584	biolink:PhenotypicFeature	Endocarditis	An inflammation of the endocardium, the inner layer of the heart, which usually involves the heart valves.	SNOMEDCT_US:56819008|UMLS:C0014118|MSH:D004696	hp.json		http://purl.obolibrary.org/obo/HP_0100584		
HP:0100581	biolink:PhenotypicFeature	Dilatation of renal calices	An abnormal enlargement of the renal calices, the system of ducts of the kidney that collect urine.	UMLS:C4022019	hp.json	Caliectasis|Caliceal dilatation|Megacalicosis	http://purl.obolibrary.org/obo/HP_0100581		
HP:0100582	biolink:PhenotypicFeature	Nasal polyposis	Polypoidal masses arising mainly from the mucous membranes of the nose and paranasal sinuses. They are freely movable and nontender overgrowths of the mucosa that frequently accompany allergic rhinitis.	MSH:D009298|UMLS:C0027430|SNOMEDCT_US:52756005	hp.json	Polyposis nasi|Polyps of nose|Nasal polyps	http://purl.obolibrary.org/obo/HP_0100582		
HP:0100580	biolink:PhenotypicFeature	Barrett esophagus	An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system.	MSH:D001471|SNOMEDCT_US:302914006|UMLS:C0004763	hp.json	Endobrachyesophagus|Barrett's esophagus|Barrett's oesophagus|Barret syndrome|Barrett oesophagus	http://purl.obolibrary.org/obo/HP_0100580		
GO:0042582	biolink:CellularComponent	azurophil granule	Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.		hp.json	primary granule	http://purl.obolibrary.org/obo/GO_0042582		
RO:0002503	biolink:NamedThing	towards	q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2	RO:0002503	hp.json		http://purl.obolibrary.org/obo/RO_0002503		
RO:0002506	biolink:NamedThing	causal relation between entities			hp.json		http://purl.obolibrary.org/obo/RO_0002506		
RO:0002500	biolink:NamedThing	causal agent in process	A relationship between a material entity and a process where the material entity has some causal role that influences the process		hp.json		http://purl.obolibrary.org/obo/RO_0002500		
RO:0002501	biolink:NamedThing	causal relation between processes	p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.		hp.json		http://purl.obolibrary.org/obo/RO_0002501		
RO:0002502	biolink:NamedThing	depends on			hp.json		http://purl.obolibrary.org/obo/RO_0002502		
HP:0100598	biolink:PhenotypicFeature	Pulmonary edema	Fluid accumulation in the lungs.	UMLS:C0034063|SNOMEDCT_US:19242006|MSH:D011654	hp.json	Lung oedema|Pulmonary oedema|Wet lung|Excess fluid in lungs|Lung edema	http://purl.obolibrary.org/obo/HP_0100598		
HP:0100599	biolink:PhenotypicFeature	Bifid penis	Two penile structures, separated from the tip to the base of the shaft.	UMLS:C0345322|SNOMEDCT_US:253851000	hp.json	Penile duplication|Diphallia	http://purl.obolibrary.org/obo/HP_0100599		
HP:0100596	biolink:PhenotypicFeature	Absent nares	The nostrils (the paired channels of the nose) are not present.	UMLS:C4020963|UMLS:C4020707	hp.json	Aplasia/Hypoplasia of the nares|Abouphalia|Missing nostrils|Aplasia of the nares	http://purl.obolibrary.org/obo/HP_0100596		
HP:0100594	biolink:PhenotypicFeature	Esophageal web	Thin (2-3mm) membranes of normal esophageal tissue consisting of mucosa and submucosa that can be congenital or acquired. Congenital webs commonly appear in the middle and inferior third of the esophagus, and they are more likely to be circumferential with a central or eccentric orifice. Acquired webs are much more common than congenital webs and typically appear in the cervical area (postcricoid). Clinical symptoms of this condition are selective (solid more than liquids) dysphagia, thoracic pain, nasopharyngeal reflux, aspiration, perforation and food impaction (the last two are very rare).	UMLS:C0267080|SNOMEDCT_US:19216006|SNOMEDCT_US:22395006	hp.json		http://purl.obolibrary.org/obo/HP_0100594		hposlim_core
HP:0100595	biolink:PhenotypicFeature	Camptocormia	An abnormal forward-flexed posture e.g. forward flexion of the spine, which is noticeable when standing or walking but disappears when lying down. It is becoming an increasingly recognized feature of Parkinson's disease and dystonic disorders.	UMLS:C0264162|SNOMEDCT_US:13534001|MSH:C537968	hp.json		http://purl.obolibrary.org/obo/HP_0100595		hposlim_core
HP:0100592	biolink:PhenotypicFeature	Peritoneal abscess	The presence of an abscess of the peritoneum.	UMLS:C0267756|SNOMEDCT_US:73962000	hp.json		http://purl.obolibrary.org/obo/HP_0100592		
HP:0100593	biolink:PhenotypicFeature	Calcification of cartilage		UMLS:C4022015	hp.json		http://purl.obolibrary.org/obo/HP_0100593		
HP:0100590	biolink:PhenotypicFeature	Rectal fistula	The presence of a fistula affecting the rectum.	MSH:D012003|SNOMEDCT_US:80736008|UMLS:C0034884	hp.json		http://purl.obolibrary.org/obo/HP_0100590		
GO:0042592	biolink:BiologicalProcess	homeostatic process	Any biological process involved in the maintenance of an internal steady state.		hp.json	positive regulation of homeostatic process|homeostasis|negative regulation of homeostatic process|inhibition of homeostatic process|regulation of homeostatic process|activation of homeostatic process	http://purl.obolibrary.org/obo/GO_0042592		goslim_agr|goslim_chembl|goslim_mouse
GO:0042593	biolink:BiologicalProcess	glucose homeostasis	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0042593		
UBERON:0018542	biolink:AnatomicalEntity	mandibular symphyseal region	The region of the mandible on or near the midline (near the mandiblular symphysis).	MFMO:0000147	hp.json	symphyseal region	http://purl.obolibrary.org/obo/UBERON_0018542		
UBERON:0018543	biolink:AnatomicalEntity	lumen of intestine	The anatomical space within the intestine.	FMA:14586|WBbt:0005791|ZFA:0005807|TADS:0000495	hp.json	gut lumen|intestinal lumen|intestine lumen	http://purl.obolibrary.org/obo/UBERON_0018543		
CHEBI:57726	biolink:ChemicalSubstance	D-proline zwitterion	A D-alpha-amino acid zwitterion that is D-proline in which a proton has been transferred from the carboxy group to the amino group. It is the major species at pH 7.3.	MetaCyc:D-PROLINE	hp.json	(2R)-pyrrolidinium-2-carboxylate|D-proline	http://purl.obolibrary.org/obo/CHEBI_57726		3_STAR
UBERON:0018544	biolink:AnatomicalEntity	trigeminal nerve muscle	Muscle innervated by the trigeminal nerve (Cranial Nerve V).	MFMO:0000072	hp.json	muscle innervated by the trigeminal nerve|muscles innervated by the trigeminal nerve	http://purl.obolibrary.org/obo/UBERON_0018544		
HP:0002256	biolink:PhenotypicFeature	Small bowel diverticula		UMLS:C0267498|SNOMEDCT_US:8114009|MEDDRA:10013533	hp.json		http://purl.obolibrary.org/obo/HP_0002256		hposlim_core
CHEBI:70709	biolink:ChemicalSubstance	progesterone receptor agonist	A hormone agonist that binds to and activates progesterone receptors.		hp.json	progesterone receptor agonists|PR agonists|PR agonist	http://purl.obolibrary.org/obo/CHEBI_70709		3_STAR
HP:0002257	biolink:PhenotypicFeature	Chronic rhinitis	Chronic inflammation of the nasal mucosa.	UMLS:C0008711|SNOMEDCT_US:86094006	hp.json		http://purl.obolibrary.org/obo/HP_0002257		
UBERON:0006563	biolink:AnatomicalEntity	tunica media of pulmonary trunk	Tunica media of artery which is continuous with the myocardium of right ventricle.[FMA].	FMA:85030	hp.json		http://purl.obolibrary.org/obo/UBERON_0006563		
UBERON:0006562	biolink:AnatomicalEntity	pharynx	The pharynx is the part of the digestive system immediately posterior to the mouth[GO].	MAT:0000049|MIAA:0000049|FBbt:00005380|MESH:D010614	hp.json	pharyngeal tube|anterior part of foregut	http://purl.obolibrary.org/obo/UBERON_0006562		grouping_class|uberon_slim
HP:0002254	biolink:PhenotypicFeature	Intermittent diarrhea	Repeated episodes of diarrhea separated by periods without diarrhea.	UMLS:C0239181	hp.json	Episodic diarrhea|Episodic diarrhoea|Intermittent diarrhoea	http://purl.obolibrary.org/obo/HP_0002254		
UBERON:0006561	biolink:AnatomicalEntity	non-lymphatic part of lymphoid system	An organ system subdivision that is the part of the lymphoid system that excludes the lymphatic vessels..	FMA:74623	hp.json	non-lymphatic lymphoid system	http://purl.obolibrary.org/obo/UBERON_0006561		
CHEBI:33752	biolink:ChemicalSubstance	hexonic acid	Any aldonic acid formed by oxidising the aldehyde group of an aldohexose to a carboxylic acid group.		hp.json	hexonic acid|hexonic acids|aldohexonic acids	http://purl.obolibrary.org/obo/CHEBI_33752		3_STAR
UBERON:0006569	biolink:AnatomicalEntity	diencephalic nucleus	A nucleus of brain that is part of a diencephalon.	TAO:0002191|ZFA:0001659	hp.json		http://purl.obolibrary.org/obo/UBERON_0006569		
UBERON:0006568	biolink:AnatomicalEntity	hypothalamic nucleus	A nucleus of brain that is part of a hypothalamus.	MA:0002426|FMA:258762|BTO:0002449|EMAPA:35417	hp.json	nucleus of hypothalamus	http://purl.obolibrary.org/obo/UBERON_0006568		
HP:0002253	biolink:PhenotypicFeature	Colonic diverticula	The presence of multiple diverticula of the colon.	MSH:D004241|UMLS:C0012819|SNOMEDCT_US:398050005|MSH:D043963|UMLS:C0012811|MEDDRA:10009993	hp.json	Colon diverticula|Colonic diverticulosis	http://purl.obolibrary.org/obo/HP_0002253		hposlim_core
UBERON:0006567	biolink:AnatomicalEntity	right ventricle myocardium	A myocardium that is part of a right ventricle of a heart.	FMA:9535|MA:0002984|EMAPA:17342|SCTID:362020004	hp.json	myocardium of right ventricle|right ventricular myocardium	http://purl.obolibrary.org/obo/UBERON_0006567		pheno_slim|human_reference_atlas
UBERON:0006566	biolink:AnatomicalEntity	left ventricle myocardium	A myocardium that is part of a left ventricle of a heart.	FMA:9558|MA:0002983|SCTID:362021000|EMAPA:17339	hp.json	myocardium of left ventricle|left ventricular myocardium	http://purl.obolibrary.org/obo/UBERON_0006566		human_reference_atlas
HP:0002250	biolink:PhenotypicFeature	Abnormal large intestine morphology	Any abnormality of the large intestine.	UMLS:C4025715	hp.json	Abnormality of the large intestine	http://purl.obolibrary.org/obo/HP_0002250		
RO:0002608	biolink:NamedThing	process has causal agent	Inverse of 'causal agent in process'	RO:0002608	hp.json		http://purl.obolibrary.org/obo/RO_0002608		
UBERON:0006565	biolink:AnatomicalEntity	female urethral meatus	A urethral meatus that is part of a female urethra[Automatically generated definition].	EMAPA:36453|FMA:85266|MA:0002639	hp.json	external urethral orifice (female)|urethral meatus of clitoral urethra|female urethral meatus|urethral opening of clitoral urethra|distal urethral opening of female|ostium urethrae externum (urethra feminina)|external orifice of female urethra	http://purl.obolibrary.org/obo/UBERON_0006565		
HP:0002251	biolink:PhenotypicFeature	Aganglionic megacolon	An abnormality resulting from a lack of intestinal ganglion cells (i.e., an aganglionic section of bowel) that results in bowel obstruction with enlargement of the colon.	SNOMEDCT_US:33995003|MSH:D006627|SNOMEDCT_US:367495003|UMLS:C0025160|MEDDRA:10027110|SNOMEDCT_US:204739008|UMLS:C0019569|MSH:D008531	hp.json	Hirschsprung disease|Congenital megacolon|Hirschsprung megacolon|Megacolon|Enlarged colon lacking nerve cells	http://purl.obolibrary.org/obo/HP_0002251		hposlim_core
UBERON:0018531	biolink:AnatomicalEntity	female superficial inguinal ring	A deep inguinal ring that is part of a female reproductive system.	EMAPA:19174|MA:0003252	hp.json	female external inguinal ring	http://purl.obolibrary.org/obo/UBERON_0018531		
GO:0005506	biolink:MolecularActivity	iron ion binding	Binding to an iron (Fe) ion.		hp.json	iron binding	http://purl.obolibrary.org/obo/GO_0005506		
UBERON:0018532	biolink:AnatomicalEntity	female deep inguinal ring	A deep inguinal ring that is part of a male reproductive system.	EMAPA:19173|MA:0003251	hp.json	female internal inguinal ring	http://purl.obolibrary.org/obo/UBERON_0018532		
NBO:0000747	biolink:NamedThing	jaw movement			hp.json		http://purl.obolibrary.org/obo/NBO_0000747		
UBERON:0018530	biolink:AnatomicalEntity	male inguinal ring	An inguinal ring that is part of a male reproductive system.	EMAPA:29307	hp.json		http://purl.obolibrary.org/obo/UBERON_0018530		
NBO:0000741	biolink:NamedThing	aggressive behavior by means			hp.json		http://purl.obolibrary.org/obo/NBO_0000741		
CHEBI:33767	biolink:ChemicalSubstance	cobalt group molecular entity			hp.json	cobalt group molecular entities|cobalt group molecular entity	http://purl.obolibrary.org/obo/CHEBI_33767		3_STAR
HP:0002267	biolink:PhenotypicFeature	Exaggerated startle response	An exaggerated startle reaction in response to a sudden unexpected visual or acoustic stimulus, or a quick movement near the face.	SNOMEDCT_US:19557000|UMLS:C0234166|UMLS:C1836014|MSH:D000071017|UMLS:C1740801|UMLS:C1848918	hp.json	Increased startle response|Hyperekplexia|Exaggerated acoustic startle response	http://purl.obolibrary.org/obo/HP_0002267		
UBERON:0006553	biolink:AnatomicalEntity	renal duct	A tube in the kidney that collect and transport urine.	ZFA:0005289|TAO:0005289	hp.json		http://purl.obolibrary.org/obo/UBERON_0006553		
HP:0002268	biolink:PhenotypicFeature	Paroxysmal dystonia	A form of dystonia characterized by episodes of dystonia (often hemidystonia or generalized) lasting from minutes to hours. There are no dystonic symptoms between episodes.	UMLS:C0393588|MSH:D004421|SNOMEDCT_US:230310003	hp.json	Episodic dystonia	http://purl.obolibrary.org/obo/HP_0002268		
CHEBI:33760	biolink:ChemicalSubstance	hexonate			hp.json	hexonate|hexonates|aldohexonates	http://purl.obolibrary.org/obo/CHEBI_33760		3_STAR
HP:0002265	biolink:PhenotypicFeature	Large fleshy ears		UMLS:C3808403	hp.json	Large fleshy ears	http://purl.obolibrary.org/obo/HP_0002265		
HP:0002266	biolink:PhenotypicFeature	Focal clonic seizure	A focal clonic seizure is a type of focal motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive.	MSH:D020938|UMLS:C0752323	hp.json	Localized clonic seizure|Focal clonic seizures|Localised clonic seizure|Partial clonic seizure|Segmental clonic seizure	http://purl.obolibrary.org/obo/HP_0002266		
HP:0002269	biolink:PhenotypicFeature	Abnormality of neuronal migration	An abnormality resulting from an anomaly of neuronal migration, i.e., of the process by which neurons travel from their origin to their final position in the brain.	MSH:D054081|UMLS:C1837249	hp.json	Neuronal migration disorder|Heterotopias/abnormal migration|Abnormal neuronal migration|Migrational brain disorder	http://purl.obolibrary.org/obo/HP_0002269		
NBO:0000751	biolink:NamedThing	perception behavior by means			hp.json		http://purl.obolibrary.org/obo/NBO_0000751		
UBERON:0006558	biolink:AnatomicalEntity	lymphatic part of lymphoid system	An organ system subdivision that is a network of vessels capable of removing accumulating protein and fluid from the interstitial space and returning it to the vascular space. In some species, this network is connected to the immune system via lymph nodes and lymphocyte-producing organs, with the whole being the lymphoid system.	VHOG:0001761|EMAPA:18248|CALOHA:TS-2024|MA:0002961|AAO:0010522|MESH:D008208|FMA:7162|EFO:0000870	hp.json	lymphatic tree system|lymphatic system|lymporeticular system	http://purl.obolibrary.org/obo/UBERON_0006558		pheno_slim|efo_slim
HP:0002263	biolink:PhenotypicFeature	Exaggerated cupid's bow	More pronounced paramedian peaks and median notch of the Cupid's bow.	UMLS:C1850629	hp.json	Prominent cupid-bow of upper lip|Exaggerated cupid's bow|Cupid bow upper lip|Cupid's bow, accentuated|Cupid-bow shaped upper lip	http://purl.obolibrary.org/obo/HP_0002263		hposlim_core
CHEBI:18101	biolink:ChemicalSubstance	4-hydroxyphenylacetic acid	A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.	CAS:156-38-7|CAS:156-38-7|PMID:7126379|PMID:21476434|Wikipedia:4-hydroxyphenylacetic_acid|MetaCyc:4-HYDROXYPHENYLACETATE|PDBeChem:4HP|Reaxys:1448766|PMID:22296160|PMID:24831010|PMID:24636068|PMID:977696|HMDB:HMDB0000020|PMID:11339992|CAS:156-38-7|KEGG:C00642|UM-BBD_compID:c0271	hp.json	4-carboxymethylphenol|4-Hydroxyphenylacetic acid|4-hydroxybenzeneacetic acid|(4-hydroxyphenyl)acetic acid|p-hydroxyphenylacetic acid|(p-hydroxyphenyl)acetic acid|4-Hydroxyphenylacetate	http://purl.obolibrary.org/obo/CHEBI_18101		3_STAR
UBERON:0006555	biolink:AnatomicalEntity	excretory tube	A tube that is part of a excretory system.		hp.json		http://purl.obolibrary.org/obo/UBERON_0006555		
CHEBI:18140	biolink:ChemicalSubstance	hydrogen halide			hp.json	HX|hydrogen halides|hydrogen halides|hydrogen halide	http://purl.obolibrary.org/obo/CHEBI_18140		3_STAR
UBERON:0018529	biolink:AnatomicalEntity	female inguinal ring	An inguinal ring that is part of a female reproductive system.	MA:0003250|EMAPA:19172	hp.json		http://purl.obolibrary.org/obo/UBERON_0018529		
HP:0002234	biolink:PhenotypicFeature	Early balding	Loss of scalp hair at an earlier than normal age.	UMLS:C4025718	hp.json	Early balding	http://purl.obolibrary.org/obo/HP_0002234		
HP:0004897	biolink:PhenotypicFeature	Stress/infection-induced lactic acidosis	A form of lactic acidemia that occurs in relation to stress or infection.	UMLS:C4025278	hp.json	Metabolic crises during febrile infections	http://purl.obolibrary.org/obo/HP_0004897		
HP:0002235	biolink:PhenotypicFeature	Pili canaliculi	Uncombable hair.	UMLS:C1860608	hp.json		http://purl.obolibrary.org/obo/HP_0002235		
HP:0002232	biolink:PhenotypicFeature	Patchy alopecia	Transient, non-scarring hair loss and preservation of the hair follicle located in in well-defined patches.	SNOMEDCT_US:68225006|UMLS:C1862862|MSH:D000506|MSH:C531609|UMLS:C0002171	hp.json	Alopecia areata|Patchy baldness	http://purl.obolibrary.org/obo/HP_0002232		
HP:0004894	biolink:PhenotypicFeature	Laryngotracheal stenosis		UMLS:C3806280	hp.json		http://purl.obolibrary.org/obo/HP_0004894		
HP:0002239	biolink:PhenotypicFeature	Gastrointestinal hemorrhage	Hemorrhage affecting the gastrointestinal tract.	UMLS:C0017181|SNOMEDCT_US:74474003|MSH:D006471	hp.json	Gastrointestinal bleeding|GI hemorrhage|GI haemorrhage|Gastrointestinal haemorrhage	http://purl.obolibrary.org/obo/HP_0002239		
HP:0002236	biolink:PhenotypicFeature	Frontal upsweep of hair	Upward and/or sideward growth of anterior hair.	UMLS:C2675540|UMLS:C1185616|UMLS:C3275754	hp.json	Frontal Cowlick|Upswept frontal hair|Frontal upsweep of hair|Cowlick|Upswept frontal hairline|Upswept frontal hair pattern	http://purl.obolibrary.org/obo/HP_0002236		hposlim_core
CHEBI:18139	biolink:ChemicalSubstance	trimethylamine	A tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group.	Reaxys:956566|Wikipedia:Trimethylamine|PMID:17190852|MetaCyc:TRIMETHYLAMINE|PMID:24591617|CAS:75-50-3|CAS:75-50-3|PMID:2501587|HMDB:HMDB0000906|KNApSAcK:C00001433|PMID:1801314|PMID:15752091|PMID:14047118|PMID:15304308|Gmelin:1309|KEGG:C00565|PMID:5161463|Beilstein:956566|CAS:75-50-3|PDBeChem:KEN	hp.json	N,N,N-trimethylamine|(CH3)3N|Trimethylamine|N,N-Dimethylmethanamine|TMA|N(CH3)3|tridimethylaminomethane|NMe3|N,N-dimethylmethanamine|Trimethylamin	http://purl.obolibrary.org/obo/CHEBI_18139		3_STAR
HP:0004898	biolink:PhenotypicFeature	Persistent lactic acidosis	A continuous form of lactic acidemia.	UMLS:C3554538	hp.json		http://purl.obolibrary.org/obo/HP_0004898		
CHEBI:18133	biolink:ChemicalSubstance	hexose	Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose).	GlyTouCan:G70994MS|KEGG:C00738|GlyGen:G70994MS	hp.json	Hexose|WURCS=2.0/1,1,0/[axxxxh-1x_1-5_2*NCC/3=O]/1/|hexoses	http://purl.obolibrary.org/obo/CHEBI_18133		3_STAR
HP:0002230	biolink:PhenotypicFeature	Generalized hirsutism	Abnormally increased hair growth over much of the entire body.	UMLS:C1849211	hp.json	Generalised hirsutism|Excessive hairiness over body	http://purl.obolibrary.org/obo/HP_0002230		
HP:0002231	biolink:PhenotypicFeature	Sparse body hair	Sparseness of the body hair.	UMLS:C1862863	hp.json	Limited body hair|Sparse body hair|Little body hair|Sparse to absent body hair	http://purl.obolibrary.org/obo/HP_0002231		hposlim_core
HP:0004891	biolink:PhenotypicFeature	Recurrent infections due to aspiration	Increased susceptibility to infections due to aspiration, as manifested by recurrent episodes of infections due to aspiration.	UMLS:C3806285	hp.json		http://purl.obolibrary.org/obo/HP_0004891		
UBERON:0006544	biolink:AnatomicalEntity	kidney vasculature	A vasculature that is part of a kidney.	EMAPA:28457|ZFA:0005305|TAO:0005305	hp.json		http://purl.obolibrary.org/obo/UBERON_0006544		vertebrate_core|human_reference_atlas
HP:0004890	biolink:PhenotypicFeature	Elevated pulmonary artery pressure	An abnormally elevated blood pressure in the circulation of the pulmonary artery.	UMLS:C3805917	hp.json	Elevated lung artery pressure|increased pulmonary artery pressure	http://purl.obolibrary.org/obo/HP_0004890		
CHEBI:21760	biolink:ChemicalSubstance	N-methyl-amino acid	An amino acid derivative in which at least one of the hydrogens of the amino group has been replaced by a methyl group.		hp.json	N-methyl-amino acids	http://purl.obolibrary.org/obo/CHEBI_21760		3_STAR
HP:0002245	biolink:PhenotypicFeature	Meckel diverticulum	Meckel's diverticulum is a congenital diverticulum located in the distal ileum.	MSH:D008467|UMLS:C0025037|SNOMEDCT_US:37373007|MEDDRA:10027055|SNOMEDCT_US:127962001	hp.json		http://purl.obolibrary.org/obo/HP_0002245		
UBERON:0006531	biolink:AnatomicalEntity	oculomotor muscle	The muscles that move the eye. Included in this group are the medial rectus, lateral rectus, superior rectus, inferior rectus, inferior oblique, superior oblique, musculus orbitalis, and levator palpebrae superioris.	UMLS:C0028863|MA:0002432|NCIT:C33199|MESH:D009801|CALOHA:TS-0305	hp.json		http://purl.obolibrary.org/obo/UBERON_0006531		
UBERON:0006530	biolink:AnatomicalEntity	seminal fluid	A substance formed from the secretion of one or more glands of the male genital tract in which sperm cells are suspended.	BTO:0001232|EMAPA:36543|CALOHA:TS-0918|MA:0002523|FMA:62967|MAT:0000057|MIAA:0000057	hp.json	seminal fluid|male genital fluid|male genital secretion|seminal plasma	http://purl.obolibrary.org/obo/UBERON_0006530		
HP:0002246	biolink:PhenotypicFeature	Abnormal duodenum morphology	An abnormality of the duodenum, i.e., the first section of the small intestine.	UMLS:C4025716	hp.json	Abnormality of the duodenum	http://purl.obolibrary.org/obo/HP_0002246		hposlim_core
HP:0002243	biolink:PhenotypicFeature	Protein-losing enteropathy	Abnormal loss of protein from the digestive tract related to excessive leakage of plasma proteins into the lumen of the gastrointestinal tract.	SNOMEDCT_US:66972006|UMLS:C0033680|MSH:D011504|SNOMEDCT_US:22542007	hp.json		http://purl.obolibrary.org/obo/HP_0002243		
HP:0002244	biolink:PhenotypicFeature	Abnormality of the small intestine	An abnormality of the small intestine.	UMLS:C4025717	hp.json		http://purl.obolibrary.org/obo/HP_0002244		
HP:0002249	biolink:PhenotypicFeature	Melena	The passage of blackish, tarry feces associated with gastrointestinal hemorrhage. Melena occurs if the blood remains in the colon long enough for it to be broken down by colonic bacteria. One degradation product, hematin, imbues the stool with a blackish color. Thus, melena generally occurs with bleeding from the upper gastrointestinal tract (e.g., stomach ulcers or duodenal ulcers), since the blood usually remains in the gut for a longer period of time than with lower gastrointestinal bleeding.	SNOMEDCT_US:249627005|UMLS:C0474585|UMLS:C0025222|SNOMEDCT_US:2901004|MSH:D008551|SNOMEDCT_US:267055007|SNOMEDCT_US:269899009|SNOMEDCT_US:35064005	hp.json	Black faeces|Black feces	http://purl.obolibrary.org/obo/HP_0002249		
UBERON:0018508	biolink:AnatomicalEntity	foramen of nasal bone	A vascular foramen opening on the outer surface of a nasal bone.	FMA:57653	hp.json	foramen of nasal bone|nasal foramen|nasal foramina|foramina nasalia	http://purl.obolibrary.org/obo/UBERON_0018508		
HP:0002247	biolink:PhenotypicFeature	Duodenal atresia	A developmental defect resulting in complete obliteration of the duodenal lumen, that is, an abnormal closure of the duodenum.	Fyler:4406|MSH:C535720|MEDDRA:10013812|UMLS:C0266174|SNOMEDCT_US:51118003	hp.json	Absence or narrowing of first part of small bowel	http://purl.obolibrary.org/obo/HP_0002247		hposlim_core
CHEBI:33744	biolink:ChemicalSubstance	iron group molecular entity			hp.json	iron group molecular entity|iron group molecular entities	http://purl.obolibrary.org/obo/CHEBI_33744		3_STAR
HP:0002248	biolink:PhenotypicFeature	Hematemesis	The vomiting of blood.	MSH:D006396|SNOMEDCT_US:8765009|UMLS:C0018926	hp.json	Vomitting blood	http://purl.obolibrary.org/obo/HP_0002248		
UBERON:0006539	biolink:AnatomicalEntity	mammary gland fluid/secretion	A substance that is secreted by a mammary gland. The substance may differ depending on phase, with colostrum produced during pregancy/early lactation, and milk produced afterwards.	EMAPA:36538|MA:0002505	hp.json	lactiferous gland fluid|lactiferous gland secretion|secretion of mammary gland|mammary gland secreted fluid|mammary gland fluid|mammary gland secretion	http://purl.obolibrary.org/obo/UBERON_0006539		
UBERON:0006538	biolink:AnatomicalEntity	respiratory system fluid/secretion	A portion of organism substance that secreted_by a respiratory system.	UMLS:C1514899|MA:0002533|EMAPA:36550|NCIT:C13722	hp.json	respiratory system secretion|respiratory system fluid	http://purl.obolibrary.org/obo/UBERON_0006538		
CHEBI:21766	biolink:ChemicalSubstance	N-methylglycines	An N-alkylglycine that is sarcosine and derivatives of sarcosine arising by replacement of the hydrogen attached to the nitrogen by a hydrocarbyl group.		hp.json		http://purl.obolibrary.org/obo/CHEBI_21766		3_STAR
UBERON:0006537	biolink:AnatomicalEntity	female reproductive gland secretion	A portion of organism substance that is secreted by a female reproductive gland.	MA:0002510	hp.json	female reproductive system fluid/secretion|female reproductive system fluid|female reproductive system secretion	http://purl.obolibrary.org/obo/UBERON_0006537		
UBERON:0006536	biolink:AnatomicalEntity	male reproductive gland secretion	A portion of organism substance that is secreted by a male reproductive gland.	EMAPA:36541|MA:0002521	hp.json	male reproductive system fluid|male reproductive system secretion|male reproductive system fluid/secretion	http://purl.obolibrary.org/obo/UBERON_0006536		
UBERON:0006535	biolink:AnatomicalEntity	skin secretion	A portion of organism substance that secreted_by a zone of skin.	MA:0002537	hp.json	skin fluid|skin fluid/secretion|skin substance	http://purl.obolibrary.org/obo/UBERON_0006535		
HP:0002242	biolink:PhenotypicFeature	Abnormal intestine morphology	An abnormality of the intestine. The closely related term enteropathy is used to refer to any disease of the intestine.	MSH:D007410|UMLS:C0021831|SNOMEDCT_US:85919009	hp.json	Abnormality of the intestine|Enteropathy	http://purl.obolibrary.org/obo/HP_0002242		
UBERON:0006533	biolink:AnatomicalEntity	rectus extraocular muscle		MA:0001278|FMA:312408	hp.json		http://purl.obolibrary.org/obo/UBERON_0006533		pheno_slim
HP:0002240	biolink:PhenotypicFeature	Hepatomegaly	Abnormally increased size of the liver.	MSH:D006529|SNOMEDCT_US:80515008|UMLS:C0019209	hp.json	Enlarged liver	http://purl.obolibrary.org/obo/HP_0002240		
UBERON:0006532	biolink:AnatomicalEntity	oblique extraocular muscle		FMA:312383|MA:0001275	hp.json		http://purl.obolibrary.org/obo/UBERON_0006532		
HP:0100600	biolink:PhenotypicFeature	Penoscrotal transposition	A partial or complete positional exchange between the penis and the scrotum, with positioning of the scrotum superior to the penis.	UMLS:C1868854|MSH:C536650|SNOMEDCT_US:312005008	hp.json	Prepenile scrotum	http://purl.obolibrary.org/obo/HP_0100600		
HP:0100601	biolink:PhenotypicFeature	Eclampsia	An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders.	MSH:D004461|SNOMEDCT_US:15938005|UMLS:C0013537	hp.json		http://purl.obolibrary.org/obo/HP_0100601		
UBERON:0018584	biolink:AnatomicalEntity	secondary canine tooth		FMA:84203	hp.json	permanent canine tooth	http://purl.obolibrary.org/obo/UBERON_0018584		
UBERON:0018583	biolink:AnatomicalEntity	primary canine tooth		FMA:84202	hp.json	primary tooth C|temporary canine tooth|deciduous canine tooth	http://purl.obolibrary.org/obo/UBERON_0018583		
UBERON:0018588	biolink:AnatomicalEntity	upper first primary molar tooth		FMA:84211	hp.json	upper primary tooth D|upper first deciduous molar tooth	http://purl.obolibrary.org/obo/UBERON_0018588		
CHEBI:33719	biolink:ChemicalSubstance	alpha-amino-acid cation			hp.json	alpha-amino-acid cations|alpha-amino-acid cation|alpha-amino acid cations	http://purl.obolibrary.org/obo/CHEBI_33719		3_STAR
UBERON:0018589	biolink:AnatomicalEntity	lower first primary molar tooth		FMA:84212	hp.json	lower primary tooth D|lower first deciduous molar tooth|lower primary molar 1	http://purl.obolibrary.org/obo/UBERON_0018589		
HP:0002298	biolink:PhenotypicFeature	Absent hair		SNOMEDCT_US:297991008|UMLS:C0574763	hp.json	Absent hair	http://purl.obolibrary.org/obo/HP_0002298		
HP:0002299	biolink:PhenotypicFeature	Brittle hair	Fragile, easily breakable hair, i.e., with reduced tensile strength.	UMLS:C1851868|UMLS:C4072837|SNOMEDCT_US:25159003|UMLS:C0263490|UMLS:C1970705	hp.json	Fragile hair|Reduced tensile strength of hair|Fractured hair|Easily breakable hair|Brittle hair	http://purl.obolibrary.org/obo/HP_0002299		
CHEBI:33710	biolink:ChemicalSubstance	alpha-amino-acid residue			hp.json	alpha-amino-acid residues	http://purl.obolibrary.org/obo/CHEBI_33710		3_STAR
HP:0100608	biolink:PhenotypicFeature	Metrorrhagia	Bleeding at irregular intervals.	UMLS:C0025874|SNOMEDCT_US:237130006|MSH:D008796|SNOMEDCT_US:64996003|SNOMEDCT_US:19155002	hp.json	Abnormal uterus bleeding|Intermenstrual bleeding|Menstrual spotting	http://purl.obolibrary.org/obo/HP_0100608		
HP:0002292	biolink:PhenotypicFeature	Frontal balding	Absence of hair in the anterior midline and/or parietal areas.	SNOMEDCT_US:87872006|MSH:D000505|UMLS:C4083212|UMLS:C1864584	hp.json	Male pattern baldness|Frontal balding	http://purl.obolibrary.org/obo/HP_0002292		hposlim_core
HP:0002293	biolink:PhenotypicFeature	Alopecia of scalp		SNOMEDCT_US:298000004|UMLS:C1850535|MSH:D000505|SNOMEDCT_US:278040002|SNOMEDCT_US:56317004|UMLS:C0574769|UMLS:C0002170	hp.json	Absence of scalp hair|Scalp hair loss|Baldness|Missing scalp hair|Pathologic hair loss from scalp	http://purl.obolibrary.org/obo/HP_0002293		
HP:0100609	biolink:PhenotypicFeature	obsolete Hypermenorrhea			hp.json		http://purl.obolibrary.org/obo/HP_0100609		
HP:0100606	biolink:PhenotypicFeature	Neoplasm of the respiratory system	A tumor (abnormal growth of tissue) of the respiratory system.	SNOMEDCT_US:126667002|MSH:D012142|UMLS:C0035244|SNOMEDCT_US:448708002|NCIT:C3262	hp.json	Respiratory system tumor|Respiratory system tumour	http://purl.obolibrary.org/obo/HP_0100606		
HP:0002290	biolink:PhenotypicFeature	Poliosis	Circumscribed depigmentation of the hair of the head or the eyelashes.	SNOMEDCT_US:14240001|UMLS:C0221262	hp.json	White patch|Patch of white hair	http://purl.obolibrary.org/obo/HP_0002290		
HP:0100607	biolink:PhenotypicFeature	Dysmenorrhea	Pain during menstruation that interferes with daily activities.	MSH:D004412|SNOMEDCT_US:289900009|SNOMEDCT_US:266599000|SNOMEDCT_US:431416001|UMLS:C0013390	hp.json	Painful menstruation	http://purl.obolibrary.org/obo/HP_0100607		
HP:0100604	biolink:PhenotypicFeature	Neoplasm of the lip	A tumor (abnormal growth of tissue) of the lip.	UMLS:C4020706|UMLS:C0023761|MSH:D008048|SNOMEDCT_US:126770008|NCIT:C3262	hp.json	Tumor of the lip|Lip tumour|Lip tumor|Neoplasia of the lip|Tumour of the lip	http://purl.obolibrary.org/obo/HP_0100604		
HP:0002296	biolink:PhenotypicFeature	Progressive hypotrichosis	Progressively reduced or lacking hair growth.	UMLS:C1857048	hp.json		http://purl.obolibrary.org/obo/HP_0002296		
HP:0100605	biolink:PhenotypicFeature	Neoplasm of the larynx		MSH:D007822|UMLS:C0023055|NCIT:C3262|SNOMEDCT_US:126692004	hp.json		http://purl.obolibrary.org/obo/HP_0100605		
HP:0002297	biolink:PhenotypicFeature	Red hair		UMLS:C0239803|SNOMEDCT_US:297997007	hp.json	Red hair color|Red hair colour|Ginger hair color|Red hair|Ginger hair colour|Red head (hair color)	http://purl.obolibrary.org/obo/HP_0002297		
HP:0100602	biolink:PhenotypicFeature	Preeclampsia	Pregnancy-induced hypertension in association with significant amounts of protein in the urine.	UMLS:C0032914|SNOMEDCT_US:398254007|MSH:D011225|SNOMEDCT_US:15394000	hp.json	Pre-eclampsia	http://purl.obolibrary.org/obo/HP_0100602		
HP:0100603	biolink:PhenotypicFeature	Toxemia of pregnancy	Pregnancy-induced toxic reactions of the mother that can be as harmless as slight Maternal hypertension or as life threatening as Eclampsia.	SNOMEDCT_US:15394000|UMLS:C0032914|SNOMEDCT_US:398254007|MSH:D011225	hp.json	Hypertensive disorder of pregnancy|Toxaemia of pregnancy	http://purl.obolibrary.org/obo/HP_0100603		
UBERON:0018575	biolink:AnatomicalEntity	upper first secondary molar tooth		FMA:55811	hp.json	upper first permanent molar tooth|maxillary first secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018575		
HP:0100611	biolink:PhenotypicFeature	Multiple glomerular cysts	The presence of many cysts in the glomerulus of the kidney related to dilatation of the Bowman's capsule.	UMLS:C4022013|UMLS:C4020705	hp.json	Glomerulocystic kidney disease	http://purl.obolibrary.org/obo/HP_0100611		
HP:0100612	biolink:PhenotypicFeature	Odontogenic neoplasm	Neoplasm involving odontogenic cells, an odontogenic tumor.	SNOMEDCT_US:3833004|NCIT:C3286|SNOMEDCT_US:127578009|MSH:D009808|UMLS:C0028880	hp.json	Odontogenic tumor|Odontogenic tumour	http://purl.obolibrary.org/obo/HP_0100612		hposlim_core
UBERON:0018576	biolink:AnatomicalEntity	upper second secondary molar tooth		FMA:55812	hp.json	upper second permanent tooth|maxillary second secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018576		
HP:0100610	biolink:PhenotypicFeature	Maternal hyperphenylalaninemia	A medical history of exposure during the fetal period to hyperphenylalaninemia because the mother had phenylketonuria with inadequate control during pregnancy.	UMLS:C4022014	hp.json	High blood phenylalanine level in mother	http://purl.obolibrary.org/obo/HP_0100610		
UBERON:0018570	biolink:AnatomicalEntity	lower lateral secondary incisor tooth	A lower jaw incisor that is in_the_lateral_side_of a dentition.	FMA:55725	hp.json	lower lateral permanent incisor tooth|mandibular lateral secondary incisor tooth|mandibular lateral permanent incisor	http://purl.obolibrary.org/obo/UBERON_0018570		pheno_slim
UBERON:0018579	biolink:AnatomicalEntity	lower second secondary molar tooth		FMA:55815	hp.json	lower second permanent molar tooth|mandibular second secondary molar tooth|lower secondary molar 2	http://purl.obolibrary.org/obo/UBERON_0018579		
CHEBI:33729	biolink:ChemicalSubstance	tetritol			hp.json	tetritol|tetritols	http://purl.obolibrary.org/obo/CHEBI_33729		3_STAR
UBERON:0018578	biolink:AnatomicalEntity	lower first secondary molar tooth		FMA:55814	hp.json	lower first permanent molar tooth|mandibular first secondary molar tooth	http://purl.obolibrary.org/obo/UBERON_0018578		
UBERON:0006596	biolink:AnatomicalEntity	presumptive blood		ZFA:0000568|TAO:0000568|AAO:0000468|EFO:0003439	hp.json	future blood	http://purl.obolibrary.org/obo/UBERON_0006596		efo_slim
UBERON:0006595	biolink:AnatomicalEntity	presumptive endoderm	Presumptive structure of the blastula that will develop into endoderm.	EFO:0003437|ZFA:0000416|AAO:0000471|TAO:0000416	hp.json		http://purl.obolibrary.org/obo/UBERON_0006595		efo_slim
CHEBI:33720	biolink:ChemicalSubstance	carbohydrate acid			hp.json	carbohydrate acid|carbohydrate acids	http://purl.obolibrary.org/obo/CHEBI_33720		3_STAR
CHEBI:33721	biolink:ChemicalSubstance	carbohydrate acid anion			hp.json	carbohydrate acid anions|carbohydrate acid anion	http://purl.obolibrary.org/obo/CHEBI_33721		3_STAR
HP:0100619	biolink:PhenotypicFeature	Sertoli cell neoplasm	The presence of a neoplasm of the testis with origin in a Sertoli cell.	NCIT:C39976|UMLS:C4020704	hp.json	Sertoli cell neoplasia	http://purl.obolibrary.org/obo/HP_0100619		
HP:0100617	biolink:PhenotypicFeature	Testicular seminoma	The presence of a seminoma, an undifferentiated germ cell tumor of the testis.	NCIT:C9309|SNOMEDCT_US:36741007|SNOMEDCT_US:255107005|UMLS:C0036631|SNOMEDCT_US:443675005|MSH:D018239	hp.json		http://purl.obolibrary.org/obo/HP_0100617		
HP:0100618	biolink:PhenotypicFeature	Leydig cell neoplasia	The presence of a neoplasm of the testis with origin in a Leydig cell.	UMLS:C4022011|NCIT:C3188	hp.json		http://purl.obolibrary.org/obo/HP_0100618		
HP:0100615	biolink:PhenotypicFeature	Ovarian neoplasm	A tumor (abnormal growth of tissue) of the ovary.	UMLS:C0919267|MSH:D010051|SNOMEDCT_US:123843001|NCIT:C3262	hp.json	Ovarian neoplasia|Ovarian tumor|Neoplasm of the ovary|Ovarian tumour|Neoplasm of the ovaries|Ovarian cancer	http://purl.obolibrary.org/obo/HP_0100615		
HP:0100616	biolink:PhenotypicFeature	Testicular teratoma	The presence of a teratoma of the testis.	MSH:C562472|UMLS:C0238451|NCIT:C3403	hp.json		http://purl.obolibrary.org/obo/HP_0100616		
HP:0100613	biolink:PhenotypicFeature	Death in early adulthood	Death between the age of 16 and 40 years.	UMLS:C4022012	hp.json	Death in early adulthood	http://purl.obolibrary.org/obo/HP_0100613		
UBERON:0006598	biolink:AnatomicalEntity	presumptive structure	Portion of embryonic tissue determined by fate mapping to become a structure.	AAO:0000479|ZFA:0001116|TAO:0001116	hp.json	future structure|presumptive structures	http://purl.obolibrary.org/obo/UBERON_0006598		
HP:0100614	biolink:PhenotypicFeature	Myositis	A general term for inflammation of the muscles without respect to the underlying cause.	MSH:D009220|UMLS:C0027121|SNOMEDCT_US:26889001|SNOMEDCT_US:128496001	hp.json	Muscle inflammation	http://purl.obolibrary.org/obo/HP_0100614		
HP:0100622	biolink:PhenotypicFeature	Maternal seizure	A seizure during pregnancy.	UMLS:C4022010	hp.json	Maternal seizures	http://purl.obolibrary.org/obo/HP_0100622		
HP:0100623	biolink:PhenotypicFeature	Abnormality of corpus cavernosum		UMLS:C4022009	hp.json		http://purl.obolibrary.org/obo/HP_0100623		
UBERON:0018562	biolink:AnatomicalEntity	lower secondary canine tooth	A secondary canine tooth that is part of a lower jaw region.	FMA:55715	hp.json	permanent lower canine tooth|lower permanent canine tooth|mandibular secondary canine tooth	http://purl.obolibrary.org/obo/UBERON_0018562		
HP:0100620	biolink:PhenotypicFeature	Germinoma	A type of undifferentiated germ cell tumor that may be benign or malignant.	SNOMEDCT_US:28307001|UMLS:C0206660|MSH:D018237	hp.json		http://purl.obolibrary.org/obo/HP_0100620		
HP:0100621	biolink:PhenotypicFeature	Dysgerminoma	The presence of a dysgerminoma, i.e., an undifferentiated germ cell tumor of the ovary.	SNOMEDCT_US:60718004|MSH:D004407|NCIT:C2996|UMLS:C0013377	hp.json		http://purl.obolibrary.org/obo/HP_0100621		
UBERON:0018561	biolink:AnatomicalEntity	upper secondary canine tooth	A secondary canine tooth that is part of a upper jaw region.	FMA:55714	hp.json	permanent upper canine tooth|maxillary secondary canine tooth|upper permanent canine tooth	http://purl.obolibrary.org/obo/UBERON_0018561		
NBO:0000754	biolink:NamedThing	rapid eye movement sleep phenotype	"Observable characteristic of behavior related to the stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000754		
UBERON:0018568	biolink:AnatomicalEntity	lower central secondary incisor tooth	A lower jaw incisor that is in_the_central_side_of a dentition.	FMA:55723	hp.json	mandibular central permanent incisor|lower central permanent incisor tooth|mandibular central secondary incisor tooth	http://purl.obolibrary.org/obo/UBERON_0018568		pheno_slim
UBERON:0006585	biolink:AnatomicalEntity	vestibular organ	An organ that is part of a vestibular system.	BIRNLEX:2519|UMLS:C0682674	hp.json	balance organ	http://purl.obolibrary.org/obo/UBERON_0006585		
HP:0002277	biolink:PhenotypicFeature	Horner syndrome	An abnormality resulting from a lesion of the sympathetic nervous system characterized by a combination of unilateral ptosis, miosis, and often ipsilateral hypohidrosis and conjunctival injection.	SNOMEDCT_US:271730003|SNOMEDCT_US:12731000|UMLS:C0019937|SNOMEDCT_US:192915005|MSH:D006732	hp.json	Horner's syndrome|Oculosympathetic palsy	http://purl.obolibrary.org/obo/HP_0002277		
HP:0002270	biolink:PhenotypicFeature	Abnormality of the autonomic nervous system	An abnormality of the autonomic nervous system.	UMLS:C4025714	hp.json		http://purl.obolibrary.org/obo/HP_0002270		
HP:0002271	biolink:PhenotypicFeature	obsolete Autonomic dysregulation			hp.json		http://purl.obolibrary.org/obo/HP_0002271		
HP:0100628	biolink:PhenotypicFeature	Esophageal diverticulum	The presence of a diverticulum of the esophagus.	SNOMEDCT_US:414133009|MSH:D004936|SNOMEDCT_US:204667006|UMLS:C0014854	hp.json	Esophageal pouch	http://purl.obolibrary.org/obo/HP_0100628		
HP:0100629	biolink:PhenotypicFeature	Midline facial cleft	A congenital malformation with a cleft (gap or opening) in the midline of the face.	UMLS:C4022007	hp.json	Midline facial cleft	http://purl.obolibrary.org/obo/HP_0100629		
HP:0100626	biolink:PhenotypicFeature	Chronic hepatic failure		MSH:D058625|UMLS:C2936476|SNOMEDCT_US:235886005	hp.json	Chronic liver failure	http://purl.obolibrary.org/obo/HP_0100626		
UBERON:0006589	biolink:AnatomicalEntity	round ligament of uterus	The round ligament of the uterus originates at the uterine horns, in the parametrium. It leaves the pelvis via the deep inguinal ring, passes through the inguinal canal and continues on to the labia majora where its fibers spread and mix with the tissue of the mons pubis[WP]. A fibromuscular band that attaches to the uterus and then passes along the broad ligament, out through the inguinal ring, and into the labium majus[MESH].	GAID:130|FMA:20420|UMLS:C0035877|NCIT:C34009|MESH:D012404	hp.json	ligamentum teres uteri|ligamentum teres of uterus|Hunter's ligament|ligamentum teres uteri|round ligament of the uterus|round ligament	http://purl.obolibrary.org/obo/UBERON_0006589		
HP:0002275	biolink:PhenotypicFeature	Poor motor coordination		UMLS:C1848453	hp.json	Poor motor coordination	http://purl.obolibrary.org/obo/HP_0002275		
HP:0100627	biolink:PhenotypicFeature	Displacement of the urethral meatus	A displacement of the external urethral orifice from its normal position (in males normally placed at the tip of glans penis, in females normally placed about 2.5 cm behind the glans clitoridis and immediately in front of that of the vagina).	UMLS:C4020961	hp.json	Displacement of the external urethral orifice|Displacement of the male external urethral orifice	http://purl.obolibrary.org/obo/HP_0100627		
HP:0100624	biolink:PhenotypicFeature	Corpus cavernosum sclerosis		UMLS:C4022008	hp.json		http://purl.obolibrary.org/obo/HP_0100624		
HP:0002273	biolink:PhenotypicFeature	Tetraparesis	Weakness of all four limbs.	MSH:D011782|UMLS:C0270790|SNOMEDCT_US:91327001	hp.json	Quadriparesis	http://purl.obolibrary.org/obo/HP_0002273		
HP:0100625	biolink:PhenotypicFeature	Enlarged thorax		UMLS:C4020962	hp.json	Wide rib cage|Wide thorax	http://purl.obolibrary.org/obo/HP_0100625		
CHEBI:33709	biolink:ChemicalSubstance	amino acid	A carboxylic acid containing one or more amino groups.	Wikipedia:Amino_acid	hp.json	Aminocarbonsaeure|Aminokarbonsaeure|amino acids|Aminosaeure	http://purl.obolibrary.org/obo/CHEBI_33709		3_STAR
HP:0100633	biolink:PhenotypicFeature	Esophagitis	Inflammation of the esophagus.	MEDDRA:10030216|UMLS:C0014868|MSH:D004941|SNOMEDCT_US:16761005	hp.json	Inflammation of the oesophagus|Oesophagitis|Inflammation of the esophagus	http://purl.obolibrary.org/obo/HP_0100633		hposlim_core
UBERON:0018553	biolink:AnatomicalEntity	primary central incisor tooth			hp.json	primary central incisor	http://purl.obolibrary.org/obo/UBERON_0018553		
HP:0100634	biolink:PhenotypicFeature	Neuroendocrine neoplasm	A tumor that originates from a neuroendocrine cell.	UMLS:C0206754|SNOMEDCT_US:128928004|SNOMEDCT_US:255046005|MSH:D018358	hp.json	Neuroendocrine neoplasia	http://purl.obolibrary.org/obo/HP_0100634		
UBERON:0018554	biolink:AnatomicalEntity	primary lateral incisor tooth			hp.json	primary lateral incisor	http://purl.obolibrary.org/obo/UBERON_0018554		
HP:0100631	biolink:PhenotypicFeature	Neoplasm of the adrenal gland	A tumor (abnormal growth of tissue) of the adrenal gland.	NCIT:C3262|UMLS:C0001624|MSH:D000310|SNOMEDCT_US:127021009	hp.json	Adrenal neoplasia	http://purl.obolibrary.org/obo/HP_0100631		
UBERON:0018551	biolink:AnatomicalEntity	central incisor tooth			hp.json	central incisor	http://purl.obolibrary.org/obo/UBERON_0018551		pheno_slim
HP:0100632	biolink:PhenotypicFeature	Pulmonary sequestration	The presence of a piece lung tissue which is not attached to the pulmonary blood supply and does not communicate with the other lung tissue (not connected to the standard bronchial airways and not performing a function in respiration).	UMLS:C0006288|MSH:D001998|SNOMEDCT_US:18620009|UMLS:C4020703	hp.json	Cystic lung lesion	http://purl.obolibrary.org/obo/HP_0100632		
NBO:0000767	biolink:NamedThing	memory behavior phenotype	"Observable characteristic of behaviour related to the ability of an organism's ability to store, retain, and recall information and experiences." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000767		
UBERON:0018552	biolink:AnatomicalEntity	lateral incisor tooth			hp.json	lateral incisor	http://purl.obolibrary.org/obo/UBERON_0018552		pheno_slim
HP:0100630	biolink:PhenotypicFeature	Neoplasia of the nasopharynx		SNOMEDCT_US:126680004|NCIT:C3262|UMLS:C0027439|MSH:D009303	hp.json	Tumor of the nasopharynx|Nasopharyngeal neoplasm|Neoplasm of the nasopharynx|Tumour of the nasopharynx	http://purl.obolibrary.org/obo/HP_0100630		
NBO:0000765	biolink:NamedThing	learning and/or memory behavior phenotype	"Observable characteristic of behaviour related to the acquisition and processing of information and/or the storage and retrieval of this information over time." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000765		
UBERON:0018550	biolink:AnatomicalEntity	secondary incisor tooth		FMA:84201	hp.json	permanent incisor tooth|permanent incisor	http://purl.obolibrary.org/obo/UBERON_0018550		
CHEBI:33702	biolink:ChemicalSubstance	polyatomic cation	A cation consisting of more than one atom.		hp.json	polyatomic cations	http://purl.obolibrary.org/obo/CHEBI_33702		3_STAR
CHEBI:33703	biolink:ChemicalSubstance	amino-acid cation			hp.json	amino-acid cation|amino acid cation|amino-acid cations	http://purl.obolibrary.org/obo/CHEBI_33703		3_STAR
CHEBI:33704	biolink:ChemicalSubstance	alpha-amino acid	An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group.	KEGG:C00045|KEGG:C05167	hp.json	alpha-amino carboxylic acids|Amino acids|alpha-amino acids|Amino acid|alpha-amino acids|alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_33704		3_STAR
CHEBI:33706	biolink:ChemicalSubstance	beta-amino acid	A non-proteinogenic amino acid in which the amino group is located on the carbon atom at the position beta to the carboxy group.		hp.json	beta-amino acids|beta-amino acid	http://purl.obolibrary.org/obo/CHEBI_33706		3_STAR
CHEBI:33707	biolink:ChemicalSubstance	gamma-amino acid	A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group.		hp.json	gamma-amino acids|gamma-amino acid	http://purl.obolibrary.org/obo/CHEBI_33707		3_STAR
CHEBI:33708	biolink:ChemicalSubstance	amino-acid residue	When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue.		hp.json	amino-acid residues|protein residue|amino acid residue|amino-acid residue|amino acid residue	http://purl.obolibrary.org/obo/CHEBI_33708		3_STAR
HP:0002289	biolink:PhenotypicFeature	Alopecia universalis	Loss of all hair on the entire body.	SNOMEDCT_US:86166000|UMLS:C0263505|MSH:C537055	hp.json	Universal alopecia|Alopecia, complete	http://purl.obolibrary.org/obo/HP_0002289		
UBERON:0006574	biolink:AnatomicalEntity	pectinate line	The pectinate line (anocutaneous line, dentate line, anorectal junction) is a line which divides the upper 2/3rds and lower 1/3rd of the anal canal. Developmentally, this line represents the hindgut-proctodeum junction. It is an important anatomical landmark, and several distinctions can be made based upon the location of a structure relative to this line:.	EMAPA:19159|SCTID:245445008|NCIT:C34245|UMLS:C0821671|FMA:75383|Wikipedia:Pectinate_line	hp.json	linea anocutanea|site of anal membrane|pectinate line of anal canal|recto-anal junction|dentate line|recto-anal junction|linea pectinata canalis analis|linea anocutanea|dentate line|Hilton's 'white line'	http://purl.obolibrary.org/obo/UBERON_0006574		
HP:0002287	biolink:PhenotypicFeature	Progressive alopecia	Progressive loss of hair.	UMLS:C1851885	hp.json		http://purl.obolibrary.org/obo/HP_0002287		
CHEBI:33700	biolink:ChemicalSubstance	proteinogenic amino-acid residue			hp.json	proteinogenic amino-acid residues|standard amino-acid residues|standard amino acid residues|common amino acid residues|canonical amino-acid residue|canonical amino-acid residues	http://purl.obolibrary.org/obo/CHEBI_33700		3_STAR
HP:0002281	biolink:PhenotypicFeature	obsolete Gray matter heterotopias			hp.json		http://purl.obolibrary.org/obo/HP_0002281		
HP:0002282	biolink:PhenotypicFeature	Gray matter heterotopia	Heterotopia or neuronal heterotopia are macroscopic clusters of misplaced neurons (gray matter), most often situated along the ventricular walls or within the subcortical white matter.	SNOMEDCT_US:417338002|UMLS:C0008519|SNOMEDCT_US:128490007|MSH:D002828|SNOMEDCT_US:416286003	hp.json	Heterotopia|Neuronal heterotopia|Grey matter heterotopias|Gray matter heterotopias|Heterotopias|Grey matter heterotopia	http://purl.obolibrary.org/obo/HP_0002282		
HP:0100639	biolink:PhenotypicFeature	Erectile dysfunction	A multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological.		hp.json	Erectile abnormalities|Abnormal erection	http://purl.obolibrary.org/obo/HP_0100639		
HP:0002280	biolink:PhenotypicFeature	Enlarged cisterna magna	Increase in size of the cisterna magna, one of three principal openings in the subarachnoid space between the arachnoid and pia mater, located between the cerebellum and the dorsal surface of the medulla oblongata.	UMLS:C1853377	hp.json	Mega cisterna magna|Large cisterna magna	http://purl.obolibrary.org/obo/HP_0002280		
HP:0100637	biolink:PhenotypicFeature	obsolete Neoplasia of the nose			hp.json		http://purl.obolibrary.org/obo/HP_0100637		
HP:0002286	biolink:PhenotypicFeature	Fair hair	A lesser degree of hair pigmentation than would otherwise be expected.	UMLS:C1849221|SNOMEDCT_US:297995004|UMLS:C0239801	hp.json	Fair hair|Light colored hair|Straw colored hair|Flaxen hair colour|Sandy hair colour|Straw coloured hair|Fair hair colour|Light coloured hair|Blond hair|Fair hair color|Towhead (hair color)|Sandy hair color|Flaxen hair color	http://purl.obolibrary.org/obo/HP_0002286		
HP:0100638	biolink:PhenotypicFeature	Neoplasm of the pharynx	A neoplasm originating in the pharynx.	SNOMEDCT_US:126685009|NCIT:C3262|MSH:D010610|UMLS:C0031347	hp.json	Tumour of the pharynx|Neoplasia of the pharynx|Tumor of the pharynx|Pharyngeal neoplasm	http://purl.obolibrary.org/obo/HP_0100638		
HP:0002283	biolink:PhenotypicFeature	Global brain atrophy	Unlocalized atrophy of the brain with decreased total brain matter volume and increased ventricular size.	UMLS:C0241816	hp.json	Generalised brain degeneration|Generalised cerebral atrophy|Generalized brain atrophy|Generalized cerebral atrophy|Diffuse brain atrophy|Generalised brain atrophy|Generalized brain degeneration	http://purl.obolibrary.org/obo/HP_0002283		
NCBITaxon:78536	biolink:OrganismalEntity	Euphyllophyta		GC_ID:1	hp.json	euphyllophytes	http://purl.obolibrary.org/obo/NCBITaxon_78536		
HP:0100635	biolink:PhenotypicFeature	Carotid paraganglioma	A paraganglioma (a neuroendocrine neoplasm) originating in a carotid artery.	UMLS:C4022005	hp.json		http://purl.obolibrary.org/obo/HP_0100635		
HP:0100636	biolink:PhenotypicFeature	Pulmonary paraglioma	A rare paranglioma of the lung, tumors that arise from extra-adrenal chromaffin cells.	UMLS:C4022004	hp.json		http://purl.obolibrary.org/obo/HP_0100636		
GO:0005576	biolink:CellularComponent	extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.	Wikipedia:Extracellular	hp.json	extracellular	http://purl.obolibrary.org/obo/GO_0005576		goslim_metagenomics|goslim_mouse|goslim_yeast|goslim_candida|goslim_agr|goslim_generic|prokaryote_subset|goslim_plant|goslim_pir|goslim_flybase_ribbon|goslim_aspergillus|goslim_chembl
GO:0005577	biolink:CellularComponent	fibrinogen complex	A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.		hp.json	fibrinogen alpha chain|fibrinogen beta chain|fibrinogen|fibrinogen gamma chain	http://purl.obolibrary.org/obo/GO_0005577		
HP:0004839	biolink:PhenotypicFeature	Pyropoikilocytosis	A form of severe hemolytic anemia characterized by erythrocyte morphology reminiscent of that seen in patients after a thermal burn.	SNOMEDCT_US:9434008|UMLS:C0520739|MSH:C563004	hp.json	hereditary pyropoikilocytosis	http://purl.obolibrary.org/obo/HP_0004839		
GO:0005575	biolink:CellularComponent	cellular_component	A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome).	NIF_Subcellular:sao1337158144	hp.json	subcellular entity|cell or subcellular entity|cellular component	http://purl.obolibrary.org/obo/GO_0005575		goslim_yeast|goslim_candida|goslim_plant|goslim_pir|goslim_aspergillus|goslim_chembl|goslim_metagenomics
HP:0004836	biolink:PhenotypicFeature	Acute promyelocytic leukemia	A type of acute myeloid leukemia in which abnormal promyelocytes predominate.	SNOMEDCT_US:28950004|UMLS:C0023487|MSH:D015473|SNOMEDCT_US:110004001	hp.json	Acute promyelocytic leukaemia	http://purl.obolibrary.org/obo/HP_0004836		
HP:0004831	biolink:PhenotypicFeature	Recurrent thromboembolism	Repeated episodes of obstruction of blood flow due to an embolus, i.e., blood clot that has traveled from its point of origin within the blood stream.	UMLS:C0749398|UMLS:C4025286	hp.json	Recurrent thromboembolic disease	http://purl.obolibrary.org/obo/HP_0004831		
PATO:0000085	biolink:NamedThing	sensitivity toward	A quality inhering in a bearer by virtue of the bearer's disposition to detect or perceive external stimulation.		hp.json	sensitivity	http://purl.obolibrary.org/obo/PATO_0000085		disposition_slim|relational_slim|attribute_slim
HP:0004835	biolink:PhenotypicFeature	Microspherocytosis	The presence of erythrocytes that are sphere-shaped and reduced in size.	UMLS:C4025285	hp.json		http://purl.obolibrary.org/obo/HP_0004835		
PATO:0000082	biolink:NamedThing	persistence	A rhythm quality inhering in a bearer by virtue of the repetitiveness of bearer's rhythm.		hp.json		http://purl.obolibrary.org/obo/PATO_0000082		attribute_slim
GO:0005587	biolink:CellularComponent	collagen type IV trimer	A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.	Wikipedia:Collagen_type_IV	hp.json		http://purl.obolibrary.org/obo/GO_0005587		
GO:0005585	biolink:NamedThing	collagen type II trimer			hp.json		http://purl.obolibrary.org/obo/GO_0005585		
GO:0005583	biolink:CellularComponent	fibrillar collagen trimer	Any triple helical collagen trimer that forms fibrils.		hp.json		http://purl.obolibrary.org/obo/GO_0005583		
HP:0004848	biolink:PhenotypicFeature	Ph-positive acute lymphoblastic leukemia	A subset of acute lymphoblastic leukemia that results from a reciprocal translocation between the ABL-1 oncogene and a breakpoint cluster region (BCR), resulting in a fusion gene, BCR-ABL, that encodes an oncogenic protein with constitutively active tyrosine kinase activity.	SNOMEDCT_US:425688002|SNOMEDCT_US:426955004|UMLS:C1960397	hp.json	Philadelphia-positive acute lymphoblastic leukaemia|Philadelphia-positive acute lymphoblastic leukemia|Ph-positive acute lymphoblastic leukaemia	http://purl.obolibrary.org/obo/HP_0004848		
GO:0005584	biolink:NamedThing	collagen type I trimer			hp.json		http://purl.obolibrary.org/obo/GO_0005584		
GO:0005581	biolink:CellularComponent	collagen trimer	A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.	Wikipedia:Collagen	hp.json		http://purl.obolibrary.org/obo/GO_0005581		
HP:0004841	biolink:PhenotypicFeature	Reduced factor XII activity	Decreased activity of coagulation factor XII. Factor XII (fXII) is part of the intrinsic coagulation pathway and binds to exposed collagen at site of vessel wall injury, activated by high-MW kininogen and kallikrein, thereby initiating the coagulation cascade.	UMLS:C0015526|SNOMEDCT_US:46981006|MSH:D005175	hp.json	Factor XII deficiency|Hageman factor deficiency	http://purl.obolibrary.org/obo/HP_0004841		
HP:0004840	biolink:PhenotypicFeature	Hypochromic microcytic anemia	A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes.	SNOMEDCT_US:44666001|MSH:C536357|UMLS:C0271901	hp.json	Hypochromic, microcytic anaemia|Hypochromic, microcytic anemia|Hypochromic microcytic anaemia	http://purl.obolibrary.org/obo/HP_0004840		
HP:0004846	biolink:PhenotypicFeature	Prolonged bleeding after surgery	Bleeding that persists longer than the normal time following a surgical procedure.	UMLS:C4021646	hp.json	Protracted bleeding after surgery|Prolonged bleeding after surgery|Excessive bleeding during surgery	http://purl.obolibrary.org/obo/HP_0004846		
HP:0004845	biolink:PhenotypicFeature	Acute monocytic leukemia	The accumulation of transformed primitive hematopoietic blast cells, which lose their ability of normal differentiation and proliferation.	MSH:D007948|UMLS:C0023465|SNOMEDCT_US:22331004|SNOMEDCT_US:413441006	hp.json	AMoL|AML-M5|Acute monoblastic leukemia|Acute monocytic leukaemia|Acute monoblastic leukaemia	http://purl.obolibrary.org/obo/HP_0004845		
HP:0004844	biolink:PhenotypicFeature	Coombs-positive hemolytic anemia	A type of hemolytic anemia in which the Coombs test is positive.	SNOMEDCT_US:74789008|UMLS:C0520736	hp.json	Coombs-positive hemolytic anaemia|Direct Coombs positive	http://purl.obolibrary.org/obo/HP_0004844		
CHEBI:18186	biolink:ChemicalSubstance	tyrosine	An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	CAS:55520-40-6|KNApSAcK:C00001397|PMID:17190852|Beilstein:515881|Reaxys:515881|Gmelin:27744|CAS:556-03-6|KEGG:C01536	hp.json	Tyr|Tyrosine|tirosina|2-Amino-3-(p-hydroxyphenyl)propionic acid|Y|2-amino-3-(4-hydroxyphenyl)propanoic acid|Tyrosin|tyrosine|3-(p-Hydroxyphenyl)alanine	http://purl.obolibrary.org/obo/CHEBI_18186		3_STAR
HP:0004817	biolink:PhenotypicFeature	Drug-sensitive hemolytic anemia	A form of hemolytic anemia that is triggered by ingestion of certain drugs.	UMLS:C4025289	hp.json	Drug-sensitive hemolytic anaemia	http://purl.obolibrary.org/obo/HP_0004817		
HP:0004814	biolink:PhenotypicFeature	Fava bean-induced hemolytic anemia	A kind of hemolytic anemia that is induced by the ingestion of fava beans.	UMLS:C4021648	hp.json	Hemolytic anemia following ingestion of fava beans|Fava bean-induced hemolytic anaemia|Hemolytic anaemia following ingestion of fava beans	http://purl.obolibrary.org/obo/HP_0004814		
HP:0004819	biolink:PhenotypicFeature	Normocytic hypoplastic anemia	A type of hypoplastic anemia in which the erythrocytes have a normal cell volume (the mean corpuscular volume is within normal limits).	UMLS:C1835875	hp.json	Normocytic hypoplastic anaemia	http://purl.obolibrary.org/obo/HP_0004819		
HP:0004818	biolink:PhenotypicFeature	Paroxysmal nocturnal hemoglobinuria		SNOMEDCT_US:1963002|UMLS:C0024790|MSH:D006457	hp.json	Paroxysmal nocturnal haemoglobinuria	http://purl.obolibrary.org/obo/HP_0004818		
HP:0004813	biolink:PhenotypicFeature	Post-transfusion thrombocytopenia	Sudden onset of thrombocytopenia (reduced platelet count) within 5-10 days of the transfusion of blood products. The clinical presentation is post-transfusion purpura (PTP), wigth severe thrmbocytopenia, epistaxis, and hemorrhages.	MSH:C562868|UMLS:C0398648|UMLS:C1868252|SNOMEDCT_US:73162004	hp.json	Post-transfusion purpura	http://purl.obolibrary.org/obo/HP_0004813		
HP:0004812	biolink:PhenotypicFeature	B Acute Lymphoblastic Leukemia	A type of ALL characterized by elevated levels of B-cell lymphoblasts in the bone marrow and the blood.		hp.json	Pre-B-cell acute lymphoblastic leukemia|Pre-B-cell acute lymphoblastic leukaemia|B Acute Lymphoblastic Leukaemia	http://purl.obolibrary.org/obo/HP_0004812		
HP:0004810	biolink:PhenotypicFeature	Congenital hypoplastic anemia	A type of hypoplastic anemia with congenital onset.	SNOMEDCT_US:52951008|UMLS:C1260899|SNOMEDCT_US:234371002|MSH:D000742|SNOMEDCT_US:88854002|UMLS:C0002876|MSH:D029503	hp.json	Congenital hypoplastic anaemia|Congenital dyserythropoietic anemia|Congenital dyserythropoietic anaemia	http://purl.obolibrary.org/obo/HP_0004810		
GO:0030501	biolink:BiologicalProcess	positive regulation of bone mineralization	Any process that activates or increases the frequency, rate or extent of bone mineralization.		hp.json	up-regulation of bone mineralization|up regulation of bone mineralization|activation of bone mineralization|stimulation of bone mineralization|upregulation of bone mineralization	http://purl.obolibrary.org/obo/GO_0030501		
GO:0030502	biolink:BiologicalProcess	negative regulation of bone mineralization	Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.		hp.json	inhibition of bone mineralization|downregulation of bone mineralization|down-regulation of bone mineralization|down regulation of bone mineralization	http://purl.obolibrary.org/obo/GO_0030502		
GO:0030500	biolink:BiologicalProcess	regulation of bone mineralization	Any process that modulates the frequency, rate or extent of bone mineralization.		hp.json		http://purl.obolibrary.org/obo/GO_0030500		
HP:0004828	biolink:PhenotypicFeature	Refractory anemia with ringed sideroblasts	A type of myelodysplastic syndrome characterized by less than 5% myeloblasts in the bone marrow, but with 15% or greater red cell precursors in the marrow being abnormal iron-stuffed cells called ringed sideroblasts.	UMLS:C1264195|SNOMEDCT_US:109998009|ICD-O:M9982/3|SNOMEDCT_US:128846006	hp.json	Refractory anaemia with ringed sideroblasts|Myelodysplasia with sideroblastosis	http://purl.obolibrary.org/obo/HP_0004828		
HP:0004826	biolink:PhenotypicFeature	Folate-unresponsive megaloblastic anemia	A type of megaloblastic anemia that does not improve upon administration of folate. Since vitamin B12 acts by promoting recycling of folate, administration of vitamin B12 also does not improve this type of anemia.	UMLS:C4025287	hp.json	Folate-unresponsive megaloblastic anaemia	http://purl.obolibrary.org/obo/HP_0004826		
HP:0004825	biolink:PhenotypicFeature	Increased hemoglobin oxygen affinity	An abnormal increase in the binding affinity of hemoglobin for oxygen.	UMLS:C4021647	hp.json	Increased hemoglobin O2 affinity|Increased Hb O2 affinity|Increased haemoglobin oxygen affinity|Increased haemoglobin O2 affinity|Increased Hb oxygen affinity	http://purl.obolibrary.org/obo/HP_0004825		
HP:0004820	biolink:PhenotypicFeature	Acute myelomonocytic leukemia	An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors.	SNOMEDCT_US:110005000|MSH:D015479|UMLS:C0023479|SNOMEDCT_US:277601005|SNOMEDCT_US:30962008	hp.json	Acute myelomonocytic leukaemia	http://purl.obolibrary.org/obo/HP_0004820		
HP:0004823	biolink:PhenotypicFeature	Anisopoikilocytosis	A type of poikilocytosis characterized by the presence in the blood of erythrocytes of varying sizes and abnormal shapes.	UMLS:C2675920	hp.json		http://purl.obolibrary.org/obo/HP_0004823		
HP:0004822	biolink:PhenotypicFeature	Atypical elliptocytosis		UMLS:C1857010|MSH:C565598	hp.json		http://purl.obolibrary.org/obo/HP_0004822		
HP:0004821	biolink:PhenotypicFeature	Hypersegmentation of neutrophil nuclei	An excessive division of the lobes of the nucleus of a neutrophil.	UMLS:C4025288	hp.json	Hypersegmentation of neutrophil nuclei in peripheral blood|Hypermature neutrophils	http://purl.obolibrary.org/obo/HP_0004821		
GO:0005539	biolink:MolecularActivity	glycosaminoglycan binding	Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.		hp.json		http://purl.obolibrary.org/obo/GO_0005539		goslim_chembl
PATO:0000048	biolink:NamedThing	hardness	A physical quality inhering in a bearer by virtue of the bearer's resistance to pressure, being broken, or pierced		hp.json	impenetrability|toughness	http://purl.obolibrary.org/obo/PATO_0000048		disposition_slim|attribute_slim
PATO:0000047	biolink:NamedThing	biological sex	An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved.		hp.json		http://purl.obolibrary.org/obo/PATO_0000047		attribute_slim
HP:0002218	biolink:PhenotypicFeature	Silver-gray hair	Hypopigmented hair that appears silver-gray.	UMLS:C1836576	hp.json	Silver-gray hair colour|Silver-gray hair color|Silver-gray hair|Silvery-gray hair	http://purl.obolibrary.org/obo/HP_0002218		
PATO:0000049	biolink:NamedThing	intensity	A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force.		hp.json		http://purl.obolibrary.org/obo/PATO_0000049		attribute_slim|hpo_slim
HP:0002219	biolink:PhenotypicFeature	Facial hypertrichosis	Excessive, increased hair growth located in the facial region.	MSH:C565029|UMLS:C1851400	hp.json	Increased facial hair growth	http://purl.obolibrary.org/obo/HP_0002219		
CHEBI:33792	biolink:ChemicalSubstance	canonical ribonucleoside residue			hp.json	canonical ribonucleoside residues|common ribonucleoside residues|N|Nuc|standard ribonucleoside residues|common ribonucleoside residue	http://purl.obolibrary.org/obo/CHEBI_33792		3_STAR
HP:0002212	biolink:PhenotypicFeature	Curly hair		SNOMEDCT_US:225570000|UMLS:C0558165	hp.json	Curly hair	http://purl.obolibrary.org/obo/HP_0002212		
HP:0004875	biolink:PhenotypicFeature	Neonatal inspiratory stridor		UMLS:C4025281	hp.json		http://purl.obolibrary.org/obo/HP_0004875		
HP:0002213	biolink:PhenotypicFeature	Fine hair	Hair that is fine or thin to the touch.	SNOMEDCT_US:247546006|UMLS:C0423867	hp.json	Thinned hair|Fine hair|Thin hair texture|Fine hair texture|Thin hair shaft|Fine hair shaft|Thin hair	http://purl.obolibrary.org/obo/HP_0002213		hposlim_core
HP:0002211	biolink:PhenotypicFeature	White forelock	A triangular depigmented region of white hairs located in the anterior midline of the scalp.	UMLS:C0344312|SNOMEDCT_US:247564004	hp.json	White part of hair above forehead|Poliosis of forelock hair|Poliosis of anterior hair	http://purl.obolibrary.org/obo/HP_0002211		hposlim_core
HP:0004872	biolink:PhenotypicFeature	Incisional hernia	An abdominal hernia that occurs at a site of weakness in the abdominal wall resulting from an incompletely-healed surgical wound.	SNOMEDCT_US:236037000|MSH:D000069290|UMLS:C4021645|SNOMEDCT_US:241556001|UMLS:C0267716	hp.json	Recurrent abdominal hernia	http://purl.obolibrary.org/obo/HP_0004872		
PATO:0000044	biolink:NamedThing	frequency	A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time.		hp.json		http://purl.obolibrary.org/obo/PATO_0000044		attribute_slim|scalar_slim
HP:0002216	biolink:PhenotypicFeature	Premature graying of hair	Development of gray hair at a younger than normal age.	SNOMEDCT_US:387833009|UMLS:C0263498	hp.json	Premature graying of the hair|Premature graying|Premature hair graying|Premature graying of hair|Premature hair greying|Premature greying of hair|Early graying|Early greying|Premature greying|Premature greying of the hair	http://purl.obolibrary.org/obo/HP_0002216		hposlim_core
HP:0004879	biolink:PhenotypicFeature	Intermittent hyperventilation	Episodic hyperventilation.	SNOMEDCT_US:423427003|UMLS:C1828017	hp.json	Episodic hyperventilation|Intermittent overbreathing	http://purl.obolibrary.org/obo/HP_0004879		
HP:0004878	biolink:PhenotypicFeature	Intercostal muscle weakness	Lack of strength of the intercostal muscles, i.e., of the muscle groups running along the ribs that create and move the chest wall.	UMLS:C0240017	hp.json	Dependence on diaphragmatic breathing|Muscle weakness between ribs	http://purl.obolibrary.org/obo/HP_0004878		
HP:0002217	biolink:PhenotypicFeature	Slow-growing hair	Hair whose growth is slower than normal.	UMLS:C1832348	hp.json	Slow speed of hair growth|Slow growing hair|Slow-growing hair|Slow rate of hair growth	http://purl.obolibrary.org/obo/HP_0002217		hposlim_core
HP:0004876	biolink:PhenotypicFeature	Spontaneous neonatal pneumothorax	Pneumothorax occurring neonatally without traumatic injury to the chest or lung.	UMLS:C1857021	hp.json	Neonatal pneumothorax	http://purl.obolibrary.org/obo/HP_0004876		
HP:0002215	biolink:PhenotypicFeature	Sparse axillary hair	Reduced number or density of axillary hair.	UMLS:C1858574	hp.json	Little underarm hair|Sparse scalp, axillary, and pubic hair|sparse to absent axillary hair|Limited armpit hair|Sparse axillary and pubic hair	http://purl.obolibrary.org/obo/HP_0002215		
UBERON:0006526	biolink:AnatomicalEntity	right lung alveolar system		MA:0001784|EMAPA:35717	hp.json		http://purl.obolibrary.org/obo/UBERON_0006526		
UBERON:0006525	biolink:AnatomicalEntity	left lung alveolar system		MA:0001775|EMAPA:19001	hp.json		http://purl.obolibrary.org/obo/UBERON_0006525		
CHEBI:5520	biolink:ChemicalSubstance	gonadorelin	A ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence.	CAS:33515-09-2|Wikipedia:Gonadorelin|CAS:33515-09-2|KEGG:C07607|PMID:22112812|PMID:22289217|PMID:22761896|Reaxys:741807|PMID:21872303|PMID:22504307|DrugBank:DB00644|PMID:22214466|KEGG:D08027|Drug_Central:2958	hp.json	Gonadoliberin I|LH-Releasing factor|GnRH-I|luliberin|LH-Releasing hormone|gonadorelina|5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide|5-oxo-PHWSYGLRPGNH2|Gonadotropin-releasing factor|Follicle-stimulating hormone-releasing factor|Luteinizing hormone-releasing factor|p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2|Gonadotropin-releasing hormone I|Gonadorelin|gonadorelin|gonadorelinum	http://purl.obolibrary.org/obo/CHEBI_5520		3_STAR
UBERON:0006524	biolink:AnatomicalEntity	alveolar system	System pertaining to a bronchus and alveoli.	BTO:0000136|MA:0000416|EMAPA:32692|CALOHA:TS-1296	hp.json	bronchoalveolar system|pulmonary alveolar system	http://purl.obolibrary.org/obo/UBERON_0006524		pheno_slim
HP:0004871	biolink:PhenotypicFeature	Perineal fistula	The presence of a fistula between the bowel and the perineum.	UMLS:C0561921|SNOMEDCT_US:284077005	hp.json		http://purl.obolibrary.org/obo/HP_0004871		
HP:0004870	biolink:PhenotypicFeature	Chronic hemolytic anemia	An chronic form of hemolytic anemia.	UMLS:C1387532|SNOMEDCT_US:707480001	hp.json	Chronic hemolytic anaemia|hemolytic anemia, chronic	http://purl.obolibrary.org/obo/HP_0004870		
CHEBI:18154	biolink:ChemicalSubstance	polysaccharide	A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues.	KEGG:C00420	hp.json	Glykane|polisacaridos|polisacarido|polysaccharides|Glycane|glycans|Polysaccharide|Glykan|Glycan	http://purl.obolibrary.org/obo/CHEBI_18154		3_STAR
CHEBI:33791	biolink:ChemicalSubstance	canonical nucleoside residue			hp.json	common nucleoside residues|nucleoside residue|standard nucleoside residues|canonical nucleoside residues	http://purl.obolibrary.org/obo/CHEBI_33791		3_STAR
BSPO:0000121	biolink:NamedThing	in right side of	X in right side of Y <=> if Y is subdivided into two left and right portions, X is part of the right portion.	BSPO:0000121	hp.json		http://purl.obolibrary.org/obo/BSPO_0000121		
BSPO:0000120	biolink:NamedThing	in left side of	X in left side of Y <=> if Y is subdivided into two left and right portions, X is part of the left portion.	BSPO:0000120	hp.json		http://purl.obolibrary.org/obo/BSPO_0000120		
BSPO:0000123	biolink:NamedThing	in_anterior_side_of	X anterior side of Y <=> if Y is subdivided into two anterior and posterior portions, X is part of the anterior portion.	BSPO:0000123	hp.json		http://purl.obolibrary.org/obo/BSPO_0000123		
BSPO:0000122	biolink:NamedThing	in posterior side of	X posterior side of Y <=> if Y is subdivided into two anterior and posterior portions, X is part of the posterior portion.	BSPO:0000122	hp.json		http://purl.obolibrary.org/obo/BSPO_0000122		
BSPO:0000125	biolink:NamedThing	in_distal_side_of	x in distal side of y <=> if y is subdivided into two proximal and distal portions, y is part of the distal portion.	BSPO:0000125	hp.json		http://purl.obolibrary.org/obo/BSPO_0000125		
BSPO:0000124	biolink:NamedThing	in_proximal_side_of	x in proximal side of y <=> if y is subdivided into two proximal and distal portions, y is part of the proximal portion.	BSPO:0000124	hp.json		http://purl.obolibrary.org/obo/BSPO_0000124		
UBERON:0006508	biolink:AnatomicalEntity	interosseous muscle of autopod	Any of the muscles of the autopod region that lie between metacarpal or metatarsal bones.		hp.json	interossei|m. interosseous|interosseus muscle|interosseous	http://purl.obolibrary.org/obo/UBERON_0006508		
BSPO:0000126	biolink:NamedThing	in lateral side of	X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure	BSPO:0000126	hp.json		http://purl.obolibrary.org/obo/BSPO_0000126		
HP:0002229	biolink:PhenotypicFeature	obsolete Alopecia areata			hp.json		http://purl.obolibrary.org/obo/HP_0002229		
GO:0005540	biolink:MolecularActivity	hyaluronic acid binding	Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.		hp.json	hyaluronan binding	http://purl.obolibrary.org/obo/GO_0005540		
HP:0002223	biolink:PhenotypicFeature	Absent eyebrow	Absence of the eyebrow.	SNOMEDCT_US:253208007|UMLS:C0578682|UMLS:C4280582|UMLS:C4280581|SNOMEDCT_US:422441003|UMLS:C0431448	hp.json	Agenesis of eyebrows|Aplasia of eyebrows|Absent eyebrow|Loss of eyebrows|Failure of development of eyebrows|Absent eyebrows|Missing eyebrows	http://purl.obolibrary.org/obo/HP_0002223		hposlim_core
HP:0004886	biolink:PhenotypicFeature	Congenital laryngeal stridor		UMLS:C0265763|SNOMEDCT_US:55490007	hp.json		http://purl.obolibrary.org/obo/HP_0004886		
PATO:0000051	biolink:NamedThing	morphology	A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure.		hp.json		http://purl.obolibrary.org/obo/PATO_0000051		attribute_slim
HP:0002224	biolink:PhenotypicFeature	Woolly hair	The term woolly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter.	UMLS:C4072836|UMLS:C4072835|UMLS:C4073292|MEDDRA:10048017|UMLS:C0343073|SNOMEDCT_US:52564001	hp.json	Wooly hair|Nappy hair texture|Kinked hair|Kinky hair texture|Afro-textured hair	http://purl.obolibrary.org/obo/HP_0002224		hposlim_core
HP:0004885	biolink:PhenotypicFeature	Episodic respiratory distress		UMLS:C1844945	hp.json	respiratory distress, episodic|Episodic difficulty breathing	http://purl.obolibrary.org/obo/HP_0004885		
HP:0002221	biolink:PhenotypicFeature	Absent axillary hair	Absence of axillary hair.	UMLS:C1859392	hp.json		http://purl.obolibrary.org/obo/HP_0002221		
PATO:0000052	biolink:NamedThing	shape	A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc).		hp.json	relational shape quality	http://purl.obolibrary.org/obo/PATO_0000052		attribute_slim
HP:0002227	biolink:PhenotypicFeature	White eyelashes	White color (lack of pigmentation) of the eyelashes.	UMLS:C1836736|UMLS:C4280578	hp.json	Pale eyelashes|Blonde eyelashes|White eyelashes|Grey eyelashes|Depigmented eyelashes	http://purl.obolibrary.org/obo/HP_0002227		
HP:0004889	biolink:PhenotypicFeature	Intermittent episodes of respiratory insufficiency due to muscle weakness		UMLS:C3807025	hp.json		http://purl.obolibrary.org/obo/HP_0004889		
PATO:0000057	biolink:NamedThing	occurrence	A quality of a single process inhering in a bearer by virtue of the bearer's occurrence.		hp.json	temporal|incidence	http://purl.obolibrary.org/obo/PATO_0000057		hpo_slim|attribute_slim
HP:0002225	biolink:PhenotypicFeature	Sparse pubic hair	Reduced number or density of pubic hair.	UMLS:C1858573	hp.json	sparse to absent pubic hair|Decreased sexual hair|Sparse pubic hair	http://purl.obolibrary.org/obo/HP_0002225		hposlim_core
HP:0004887	biolink:PhenotypicFeature	Respiratory failure requiring assisted ventilation	A state of respiratory distress that requires a life saving intervention in the form of gaining airway access and instituting positive pressure ventilation.	UMLS:C4025279	hp.json	Respiratory distress requiring endotracheal intubation|Respiratory distress requiring mechanical ventilation|Respiratory distress necessitating mechanical ventilation	http://purl.obolibrary.org/obo/HP_0004887		
HP:0002226	biolink:PhenotypicFeature	White eyebrow	White color (lack of pigmentation) of the eyebrow.	UMLS:C4280579|UMLS:C1836737|UMLS:C4280580	hp.json	Pale eyebrow|White eyebrow|Blonde eyebrow|Grey eyebrow|Hypopigmented eyebrow|Depigmented eyebrow	http://purl.obolibrary.org/obo/HP_0002226		hposlim_core
UBERON:0006517	biolink:AnatomicalEntity	kidney calyx	Recesses of the kidney pelvis which divides into two wide, cup-shaped major renal calices, with each major calix subdivided into 7 to 14 minor calices. Urine empties into a minor calix from collecting tubules, then passes through the major calix, renal pelvis, and ureter to enter the urinary bladder. (From Moore, Clinically Oriented Anatomy, 3d ed, p211).	FMA:284558|NCIT:C12927|GAID:427|MA:0000369|MESH:D007670|EMAPA:18676|UMLS:C0022651	hp.json	renal calyx|calyx|renal calix|calices renales|calices renales	http://purl.obolibrary.org/obo/UBERON_0006517		pheno_slim|human_reference_atlas
UBERON:0006514	biolink:AnatomicalEntity	pallidum	Part of what are called the basal ganglia of the brain which consist of the globus pallidus and the ventral pallidum.	FMA:83684|BAMS:PAL|MA:0000889|EMAPA:32780|MBA:803	hp.json	neuraxis pallidum|pallidum of neuraxis	http://purl.obolibrary.org/obo/UBERON_0006514		
HP:0004881	biolink:PhenotypicFeature	Episodic hypoventilation		UMLS:C1844946	hp.json	Episodic slow breathing|Episodic under breathing	http://purl.obolibrary.org/obo/HP_0004881		
HP:0002220	biolink:PhenotypicFeature	Melanin pigment aggregation in hair shafts		UMLS:C1843390	hp.json		http://purl.obolibrary.org/obo/HP_0002220		
HP:0004880	biolink:PhenotypicFeature	Respiratory infections in early life	Increased susceptibility to respiratory infections in early life, as manifested by recurrent episodes of respiratory infections.	UMLS:C4025280	hp.json		http://purl.obolibrary.org/obo/HP_0004880		
CHEBI:18183	biolink:ChemicalSubstance	5-oxo-L-proline	An optically active form of 5-oxoproline having L-configuration.	KNApSAcK:C00007403|DrugBank:DB03088|Beilstein:5251861|CAS:98-79-3|CAS:98-79-3|YMDB:YMDB00107|PMID:22619187|Reaxys:82132|Beilstein:82132|PMID:17439666|HMDB:HMDB0000267|Wikipedia:Pyroglutamic_acid|PDBeChem:PCA|KEGG:C01879|MetaCyc:5-OXOPROLINE|CAS:98-79-3|Gmelin:1125330|PMID:22560249	hp.json	(-)-2-pyrrolidone-5-carboxylic acid|5-Pyrrolidone-2-carboxylic acid|L-5-Pyrrolidone-2-carboxylic acid|Pyroglutamic acid|(S)-pyroglutamic acid|Pyroglutamate|L-Pyroglutamic acid|5-oxo-L-proline|PYROGLUTAMIC ACID|(2S)-5-oxopyrrolidine-2-carboxylic acid|pidolic acid|(S)-(-)-2-pyrrolidone-5-carboxylic acid|5-Oxo-L-proline	http://purl.obolibrary.org/obo/CHEBI_18183		3_STAR
GO:0005515	biolink:MolecularActivity	protein binding	Binding to a protein.		hp.json	glycoprotein binding|protein amino acid binding	http://purl.obolibrary.org/obo/GO_0005515		goslim_candida|goslim_plant|goslim_pir|goslim_aspergillus|goslim_chembl|goslim_metagenomics
CHEBI:33778	biolink:ChemicalSubstance	galactonates			hp.json		http://purl.obolibrary.org/obo/CHEBI_33778		3_STAR
PATO:0000069	biolink:NamedThing	deviation (from_normal)	A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average.		hp.json		http://purl.obolibrary.org/obo/PATO_0000069		attribute_slim
HP:0004859	biolink:PhenotypicFeature	Amegakaryocytic thrombocytopenia	Thrombocytopenia related to lack of or severe reduction in the count of megakaryocytes.	UMLS:C0398639|SNOMEDCT_US:234482009	hp.json		http://purl.obolibrary.org/obo/HP_0004859		
HP:0004852	biolink:PhenotypicFeature	Reduced leukocyte alkaline phosphatase	Decreased alkaline phosphatase measured within leukocytes.	UMLS:C1850780	hp.json	Low leukocyte alkaline phosphatase|Reduced leukocyte ALP	http://purl.obolibrary.org/obo/HP_0004852		
HP:0004851	biolink:PhenotypicFeature	Folate-responsive megaloblastic anemia	A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of folate.	UMLS:C2749656	hp.json	Folate-responsive megaloblastic anaemia	http://purl.obolibrary.org/obo/HP_0004851		
HP:0004850	biolink:PhenotypicFeature	Recurrent deep vein thrombosis	Repeated episodes of the formation of a blot clot in a deep vein.	UMLS:C1735901|SNOMEDCT_US:710167004	hp.json	Recurrent deep vein blood clot|Recurrent venous thrombosis	http://purl.obolibrary.org/obo/HP_0004850		
HP:0004857	biolink:PhenotypicFeature	Hyperchromic macrocytic anemia	A type of anemia characterized by abnormally large erythrocytes with abnormally high amounts of haemoglobin.	UMLS:C3854594	hp.json	Hyperchromic macrocytic anaemia	http://purl.obolibrary.org/obo/HP_0004857		
HP:0004856	biolink:PhenotypicFeature	Normochromic microcytic anemia	A type of anemia characterized by an normal concentration of hemoglobin in the erythrocytes and lower than normal size of the erythrocytes.	SNOMEDCT_US:4984008|UMLS:C0271902	hp.json	Normochromic microcytic anaemia	http://purl.obolibrary.org/obo/HP_0004856		
NCBITaxon:91561	biolink:OrganismalEntity	Artiodactyla			hp.json		http://purl.obolibrary.org/obo/NCBITaxon_91561		
HP:0004855	biolink:PhenotypicFeature	Reduced protein S activity	An abnormality of coagulation related to a decreased concentration of vitamin K-dependent protein S. Protein S is a cofactor of protein C.	SNOMEDCT_US:1563006|UMLS:C0242666|MSH:D018455|UMLS:C4025284	hp.json	Protein S deficiency	http://purl.obolibrary.org/obo/HP_0004855		
PATO:0000068	biolink:NamedThing	qualitative			hp.json		http://purl.obolibrary.org/obo/PATO_0000068		
HP:0004854	biolink:PhenotypicFeature	Intermittent thrombocytopenia	Reduced platelet count that occurs sporadically, i.e., it comes and goes.	UMLS:C1839167	hp.json		http://purl.obolibrary.org/obo/HP_0004854		
GO:0005518	biolink:MolecularActivity	collagen binding	Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).		hp.json		http://purl.obolibrary.org/obo/GO_0005518		
PATO:0000060	biolink:NamedThing	spatial pattern	A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts.		hp.json	pattern|distribution	http://purl.obolibrary.org/obo/PATO_0000060		hpo_slim|attribute_slim
BSPO:0000100	biolink:NamedThing	proximal_to	x proximal to y iff x is closer to the point of attachment with the body than y.	BSPO:0000100	hp.json		http://purl.obolibrary.org/obo/BSPO_0000100		
BSPO:0000102	biolink:NamedThing	ventral_to	x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly).	BSPO:0000102	hp.json		http://purl.obolibrary.org/obo/BSPO_0000102		
HP:0002209	biolink:PhenotypicFeature	Sparse scalp hair	Decreased number of hairs per unit area of skin of the scalp.	UMLS:C1873509|UMLS:C1857042	hp.json	Sparse scalp hair|Reduced/lack of hair on scalp|Scalp hypotrichosis|Decreased number of scalp follicles|Reduction in the number of scalp follicles|Reduced amount of scalp hair|Thinning scalp hair|Hypotrichosis on scalp|Thin scalp hair	http://purl.obolibrary.org/obo/HP_0002209		
BSPO:0000107	biolink:NamedThing	deep_to	Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines.	BSPO:0000107	hp.json		http://purl.obolibrary.org/obo/BSPO_0000107		
HP:0002207	biolink:PhenotypicFeature	Diffuse reticular or finely nodular infiltrations		UMLS:C1843428	hp.json		http://purl.obolibrary.org/obo/HP_0002207		
HP:0002208	biolink:PhenotypicFeature	Coarse hair	Hair shafts are rough in texture.	UMLS:C0277959|SNOMEDCT_US:48610005|UMLS:C4072834	hp.json	Rough hair texture|Coarse hair|Coarse hair texture	http://purl.obolibrary.org/obo/HP_0002208		hposlim_core
BSPO:0000108	biolink:NamedThing	superficial_to	Near the outer surface of the organism. Thus, skin is superficial to the muscle layer.	BSPO:0000108	hp.json		http://purl.obolibrary.org/obo/BSPO_0000108		
HP:0004864	biolink:PhenotypicFeature	Refractory sideroblastic anemia	A type of sideroblastic anemia that is not responsive to treatment.	UMLS:C0002896|MSH:D000756|SNOMEDCT_US:41841004	hp.json	Refractory sideroblastic anaemia	http://purl.obolibrary.org/obo/HP_0004864		
HP:0002202	biolink:PhenotypicFeature	Pleural effusion	The presence of an excessive amount of fluid in the pleural cavity.	UMLS:C0032227|SNOMEDCT_US:60046008|MSH:D010996	hp.json	Fluid around lungs	http://purl.obolibrary.org/obo/HP_0002202		
HP:0004863	biolink:PhenotypicFeature	Compensated hemolytic anemia		UMLS:C4025283	hp.json	Compensated hemolytic anaemia	http://purl.obolibrary.org/obo/HP_0004863		
HP:0004861	biolink:PhenotypicFeature	Refractory macrocytic anemia		UMLS:C2675059	hp.json	Refractory macrocytic anaemia	http://purl.obolibrary.org/obo/HP_0004861		
HP:0002200	biolink:PhenotypicFeature	Pseudobulbar signs	Pseudobulbar signs result from injury to an upper motor neuron lesion to the corticobulbar pathways in the pyramidal tract. Patients have difficulty chewing, swallowing and demonstrate slurred speech (often initial presentation) as well as abnormal behavioral symptoms such as inappropriate emotional outbursts of uncontrolled laughter or weeping etc.	UMLS:C1838579	hp.json	Pseudobulbar symptoms	http://purl.obolibrary.org/obo/HP_0002200		
HP:0002205	biolink:PhenotypicFeature	Recurrent respiratory infections	An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections.	UMLS:C3806482	hp.json	Frequent respiratory infections|respiratory infections, recurrent|Multiple respiratory infections|Susceptibility to respiratory infections|Recurrent respiratory infections	http://purl.obolibrary.org/obo/HP_0002205		
HP:0002206	biolink:PhenotypicFeature	Pulmonary fibrosis	Replacement of normal lung tissues by fibroblasts and collagen.	UMLS:C0034069|SNOMEDCT_US:51615001|MSH:D011658	hp.json		http://purl.obolibrary.org/obo/HP_0002206		
HP:0002203	biolink:PhenotypicFeature	Respiratory paralysis	Inability to move the muscles of respiration.	SNOMEDCT_US:64228003|MSH:D012133|UMLS:C0035232	hp.json		http://purl.obolibrary.org/obo/HP_0002203		
HP:0004866	biolink:PhenotypicFeature	Impaired ADP-induced platelet aggregation	Abnormal platelet response to ADP as manifested by reduced or lacking aggregation of platelets upon addition of ADP.	UMLS:C4025282	hp.json		http://purl.obolibrary.org/obo/HP_0004866		
HP:0002204	biolink:PhenotypicFeature	Pulmonary embolism	An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery.	SNOMEDCT_US:59282003|UMLS:C0034065|MSH:D011655	hp.json	Blood clot in artery of lung	http://purl.obolibrary.org/obo/HP_0002204		
PATO:0000078	biolink:NamedThing	rhythm quality	A quality of a single process inhering in a bearer by virtue of the bearer's movement or variation characterized by the regular recurrence or alternation of different quantities or conditions.		hp.json		http://purl.obolibrary.org/obo/PATO_0000078		attribute_slim
HP:0004860	biolink:PhenotypicFeature	Thiamine-responsive megaloblastic anemia	A type of megaloblastic anemia (i.e., anemia characterized by the presence of erythroblasts that are larger than normal) that improves upon the administration of thiamine.	SNOMEDCT_US:12907000|UMLS:C0271972	hp.json	Thiamine-responsive megaloblastic anaemia	http://purl.obolibrary.org/obo/HP_0004860		
PATO:0000070	biolink:NamedThing	amount	The number of entities of this type that are part of the whole organism.		hp.json	quantitative|count in organism|presence|number|presence or absence in organism	http://purl.obolibrary.org/obo/PATO_0000070		attribute_slim
HP:0031380	biolink:PhenotypicFeature	Abnormal B cell proliferation	Any abnormality in the multiplication or reproduction of B cells, which results in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/HP_0031380		
HP:0031381	biolink:PhenotypicFeature	Decreased lymphocyte proliferation in response to mitogen	A decreased proliferative response of lymphocytes in vitro or in vivo, when stimulated with mitogens, such as phytohemagglutinin (PHA).		hp.json	Reduced lymphocyte proliferation to mitogen	http://purl.obolibrary.org/obo/HP_0031381		
UBERON:0014621	biolink:AnatomicalEntity	cervical spinal cord ventral horn	A ventral horn of spinal cord that is part of a cervical spinal cord.	UMLS:C1278740|BIRNLEX:1680|SCTID:174363005|UMLS:C0228615	hp.json	cervical spinal cord ventral horn|cervical spinal cord anterior horn	http://purl.obolibrary.org/obo/UBERON_0014621		
HP:0031386	biolink:PhenotypicFeature	Increased micromegakaryocyte count	The presence of abnormally high numbers of micromegakaryocytes in the bone marrow. Micromegakaryocytes are mononuclear diploid cells, with a nucleus similar in size to that of a myeloblast or promyelocyte with the cell being less than 30 micrometers in diameter.		hp.json		http://purl.obolibrary.org/obo/HP_0031386		
HP:0031387	biolink:PhenotypicFeature	Increased multinucleated megakaryocyte count	The presence of abnormally high numbers of multinucleated megakaryocytes in the bone marrow.		hp.json		http://purl.obolibrary.org/obo/HP_0031387		
HP:0031388	biolink:PhenotypicFeature	Megakaryocyte nucleus hyperlobulation	The presence of megakaryocytes in the bone marrow whose nuclei are more lobulated than expected for the size of the nucleus.		hp.json		http://purl.obolibrary.org/obo/HP_0031388		
HP:0031389	biolink:PhenotypicFeature	Abnormal MHC II surface expression	A deviation from the normal level of major histocompatibility complex class II molecules expressed at the cell surface.		hp.json		http://purl.obolibrary.org/obo/HP_0031389		
HP:0031382	biolink:PhenotypicFeature	Decreased lymphocyte proliferation in response to anti-CD3	A decreased proliferative response of lymphocytes in vitro or in vivo, when stimulated with an anti-CD3 antibody against the T-cell co-receptor, CD3.		hp.json	Defective lymphocyte proliferation to anti-CD3|Defective proliferation of lymphocytes following anti-CD3 stimulation	http://purl.obolibrary.org/obo/HP_0031382		
HP:0031383	biolink:PhenotypicFeature	Abnormal lymphocyte surface marker expression	Abnormal amount of a protein that is normally present on the cell surface of lymphocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0031383		
HP:0031384	biolink:PhenotypicFeature	Reduced T cell CD40 expression	A deficiency in the expression of the CD40 ligand on the surface of activated T-lymphocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0031384		
HP:0031385	biolink:PhenotypicFeature	Megakaryocyte nucleus hypolobulation	The presence of megakaryocytes in the bone marrow whose nuclei are less lobulated than expected for the size of the nucleus.		hp.json		http://purl.obolibrary.org/obo/HP_0031385		
CHEBI:60466	biolink:ChemicalSubstance	peptide zwitterion	Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged.		hp.json	a peptide|peptide zwitterions	http://purl.obolibrary.org/obo/CHEBI_60466		3_STAR
UBERON:0014614	biolink:AnatomicalEntity	cervical spinal cord white matter	A white matter of spinal cord that is part of a cervical spinal cord.	BIRNLEX:1531|UMLS:C0228616|SCTID:174829001	hp.json	cervical spinal cord white matter	http://purl.obolibrary.org/obo/UBERON_0014614		
CHEBI:35492	biolink:ChemicalSubstance	cystine zwitterion	An amino acid zwitterion that is the tautomer of cystine.	Gmelin:51007	hp.json	3,3'-disulfanediylbis(2-ammoniopropanoate)|3,3'-dithiobis(2-ammoniopropanoate)	http://purl.obolibrary.org/obo/CHEBI_35492		3_STAR
HP:0031390	biolink:PhenotypicFeature	Reduced MHC II surface expression	A reduction from the normal level of major histocompatibility complex class II molecules expressed at the cell surface.		hp.json		http://purl.obolibrary.org/obo/HP_0031390		
HP:0031391	biolink:PhenotypicFeature	Elevated MHC II surface expression	An increase above the normal level of major histocompatibility complex class II molecules expressed at the cell surface.		hp.json		http://purl.obolibrary.org/obo/HP_0031391		
HP:0031392	biolink:PhenotypicFeature	Abnormal proportion of CD4-positive T cells	Any abnormality in the proportion of CD4-positive T cells relative to the total number of T cells.		hp.json	Abnormal proportion of CD4+ T cells|Abnormal proportion of CD4-positive, alpha-beta T cells	http://purl.obolibrary.org/obo/HP_0031392		
HP:0031397	biolink:PhenotypicFeature	Decreased proportion of naive T cells	An abnormally decreased proportion of naive T cells relative to the total number of T cells.		hp.json	Reduced proportion of naive T cells|Decreased proportion of naive thymus-derived, alpha-beta T cells	http://purl.obolibrary.org/obo/HP_0031397		
UBERON:0014610	biolink:AnatomicalEntity	thoracic spinal cord ventral horn	A ventral horn of spinal cord that is part of a thoracic spinal cord.	BIRNLEX:1410|UMLS:C1288552|UMLS:C0228632|SCTID:367876000	hp.json	thoracic spinal cord ventral horn|thoracic spinal cord anterior horn	http://purl.obolibrary.org/obo/UBERON_0014610		
PATO:0000499	biolink:NamedThing	decreased duration	A duration quality of a process which is relatively low.		hp.json	shortened period|low period|fast time|decreased period|decreased time	http://purl.obolibrary.org/obo/PATO_0000499		value_slim
PATO:0000498	biolink:NamedThing	increased duration	A duration quality of a process which is relatively high.		hp.json	prolonged period|chronic|increased period|high time|increased time|slow time	http://purl.obolibrary.org/obo/PATO_0000498		value_slim
HP:0031398	biolink:PhenotypicFeature	Increased proportion of naive T cells	An abnormally increased proportion of naive T cells relative to the total number of T cells.		hp.json	Elevated proportion of naive T cells|Increased proportion of naive thymus-derived, alpha-beta T cells	http://purl.obolibrary.org/obo/HP_0031398		
HP:0031399	biolink:PhenotypicFeature	Abnormal proportion of double-negative alpha-beta regulatory T cell	An abnormal proportion of CD4-negative, CD8-negative (double negative or DN) alpha-beta regulatory T cells (Tregs) as compared to total number of T cells.		hp.json	Abnormal DN Treg distribution|Abnormal CD4-negative, CD8-negative, alpha-beta regulatory T cell distribution|Abnormal Double negative Treg distribution|Abnormal double-negative alpha-beta regulatory T cell distribution	http://purl.obolibrary.org/obo/HP_0031399		
UBERON:0014613	biolink:AnatomicalEntity	cervical spinal cord gray matter	A gray matter of spinal cord that is part of a cervical spinal cord.	BIRNLEX:1521|UMLS:C0228610|SCTID:362438009	hp.json	cervical spinal cord gray matter	http://purl.obolibrary.org/obo/UBERON_0014613		
HP:0031393	biolink:PhenotypicFeature	Abnormal proportion of CD8-positive T cells	Any abnormality in the proportion of CD8 T cells relative to the total number of T cells.		hp.json	Abnormal proportion of CD8-positive, alpha-beta T cells|Abnormal proportion of CD8+ T cells	http://purl.obolibrary.org/obo/HP_0031393		
HP:0031394	biolink:PhenotypicFeature	Abnormal CD4:CD8 ratio	Any abnormality in the relative amount of CD4+ and CD8+ T lymphocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0031394		
HP:0031396	biolink:PhenotypicFeature	Abnormal proportion of naive T cells	Any abnormality in the proportion of naive T cells relative to the total number of T cells.		hp.json	Abnormal proportion of naive thymus-derived, alpha-beta T cells|Abnormal naive T cell proportion	http://purl.obolibrary.org/obo/HP_0031396		
GO:0000820	biolink:BiologicalProcess	regulation of glutamine family amino acid metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.		hp.json	regulation of glutamine family amino acid metabolism	http://purl.obolibrary.org/obo/GO_0000820		
UBERON:0002616	biolink:AnatomicalEntity	regional part of brain	Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia.	FMA:55676|NCIT:C13031|SCTID:384763002|BIRNLEX:1167|UMLS:C0445620	hp.json	neuroanatomical region|neuraxis segment|brain anatomical structure|brain biological structure|brain part|segment of brain|biological structure of brain|anatomical structure of brain	http://purl.obolibrary.org/obo/UBERON_0002616		non_informative
CHEBI:35479	biolink:ChemicalSubstance	alkali metal salt			hp.json		http://purl.obolibrary.org/obo/CHEBI_35479		
HP:0006397	biolink:PhenotypicFeature	Lateral displacement of patellae		UMLS:C1860156	hp.json		http://purl.obolibrary.org/obo/HP_0006397		
HP:0006398	biolink:PhenotypicFeature	Flat distal femoral epiphysis	An abnormal flattening of the distal epiphysis of femur.	UMLS:C4021599	hp.json	Flat end part of outermost thighbone|Flattened distal femoral epiphyses	http://purl.obolibrary.org/obo/HP_0006398		
CHEBI:35470	biolink:ChemicalSubstance	central nervous system drug	A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.		hp.json	CNS drugs|central nervous system agents|CNS agent	http://purl.obolibrary.org/obo/CHEBI_35470		3_STAR
GO:0048806	biolink:BiologicalProcess	genitalia development	The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure.		hp.json	genital development	http://purl.obolibrary.org/obo/GO_0048806		
CHEBI:35472	biolink:ChemicalSubstance	anti-inflammatory drug	A substance that reduces or suppresses inflammation.		hp.json	anti-inflammatory drugs|antiinflammatory agent|antiinflammatory drugs|antiinflammatory drug	http://purl.obolibrary.org/obo/CHEBI_35472		3_STAR
GO:0000821	biolink:BiologicalProcess	regulation of arginine metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.		hp.json	regulation of arginine metabolism	http://purl.obolibrary.org/obo/GO_0000821		
HP:0006394	biolink:PhenotypicFeature	Limited pronation/supination of forearm	A limitation of the ability to place the forearm in a position such that the palm faces anteriorly (supination) and to place the forearm in a position such that the palm faces posteriorly (pronation).	UMLS:C1861331	hp.json	Limited pronation/supination of forearm	http://purl.obolibrary.org/obo/HP_0006394		hposlim_core
CHEBI:35471	biolink:ChemicalSubstance	psychotropic drug	A loosely defined grouping of drugs that have effects on psychological function.	Wikipedia:Psychotropic_drug	hp.json	psychotropic drugs|psychoactive agent|psychoactive drugs|psychopharmaceuticals	http://purl.obolibrary.org/obo/CHEBI_35471		3_STAR
GO:0048812	biolink:BiologicalProcess	neuron projection morphogenesis	The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.		hp.json	neurite morphogenesis|neurite formation|neurite biosynthesis|neurite growth	http://purl.obolibrary.org/obo/GO_0048812		
CHEBI:35489	biolink:ChemicalSubstance	organic disulfide	Compounds of structure RSSR in which R and R' are organic groups.		hp.json	disulfides|an organic disulfide|organic disulfides	http://purl.obolibrary.org/obo/CHEBI_35489		3_STAR
CHEBI:35488	biolink:ChemicalSubstance	central nervous system depressant	A loosely defined group of drugs that tend to reduce the activity of the central nervous system.		hp.json	central nervous system depressants|CNS depressants	http://purl.obolibrary.org/obo/CHEBI_35488		3_STAR
UBERON:0002610	biolink:AnatomicalEntity	cochlear nuclear complex	The cochlear nuclei consist of: (a) the dorsal cochlear nucleus, corresponding to the tuberculum acusticum on the dorso-lateral surface of the inferior peduncle; and (b) the ventral or accessory cochlear nucleus, placed between the two divisions of the nerve, on the ventral aspect of the inferior peduncle. [WP,unvetted].	FMA:72240|EV:0100260|BM:Me-Co|BAMS:CN|DHBA:12437|MBA:607|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=720|UMLS:C0152411|BIRNLEX:1151|HBA:9528|UMLS:C0152411	hp.json	nuclei cochleares|cochlear nuclei	http://purl.obolibrary.org/obo/UBERON_0002610		uberon_slim
GO:0048821	biolink:BiologicalProcess	erythrocyte development	The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure.		hp.json	RBC development|red blood cell development	http://purl.obolibrary.org/obo/GO_0048821		
UBERON:0000017	biolink:AnatomicalEntity	exocrine pancreas	The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO].	CALOHA:TS-1241|BTO:0000434|EMAPA:35328|UMLS:C0553695|VHOG:0000048|MESH:D046790|XAO:0000137|ZFA:0001249|FMA:16017|AAO:0010407|MA:0002415|EV:0100093|NCIT:C32546|TAO:0001249	hp.json	pars exocrina pancreatis|exocrine part of pancreas|exocrine pancreas|exocrine component of pancreas	http://purl.obolibrary.org/obo/UBERON_0000017		organ_slim|pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
GO:0048822	biolink:BiologicalProcess	enucleate erythrocyte development	The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.		hp.json	enucleate red blood cell development|enucleate RBC development	http://purl.obolibrary.org/obo/GO_0048822		
UBERON:0000018	biolink:AnatomicalEntity	compound eye	A light sensing organ composed of ommatidia.	BTO:0001921|FBbt:00004508|HAO:0000217|Wikipedia:Compound_eye|TGMA:0000024	hp.json	Komplexauge|adult compound eye|Facettenauge|zusammengesetztes Auge|insect eye|faceted eye	http://purl.obolibrary.org/obo/UBERON_0000018		organ_slim|uberon_slim
UBERON:0000019	biolink:AnatomicalEntity	camera-type eye	An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid.	NCIT:C12401|EMAPA:16198|FMA:54448|MA:0000261|EHDAA2:0000484|AAO:0010340|BTO:0004688|EHDAA:936|SCTID:181143004|UMLS:C0015392|ZFA:0000107|UMLS:C1280202|BIRNLEX:1169|TAO:0000107|VHOG:0000275|UMLS:C0015392|XAO:0000179|OpenCyc:Mx8Ngx4rwKSh9pwpEbGdrcN5Y29ycB4rvVil5pwpEbGdrcN5Y29ycB4rvViTvpwpEbGdrcN5Y29ycA	hp.json	eye|eyes|camera-type eye plus associated structures|orbital part of face|regio orbitalis|vertebrate eye|orbital region	http://purl.obolibrary.org/obo/UBERON_0000019		pheno_slim|uberon_slim|vertebrate_core
GO:0048823	biolink:BiologicalProcess	nucleate erythrocyte development	The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.		hp.json	nucleate RBC development|nucleate red blood cell development	http://purl.obolibrary.org/obo/GO_0048823		
HP:0031342	biolink:PhenotypicFeature	Duodenal arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the duodenum.		hp.json		http://purl.obolibrary.org/obo/HP_0031342		
HP:0031343	biolink:PhenotypicFeature	Jejunal arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the jejunum.		hp.json		http://purl.obolibrary.org/obo/HP_0031343		
HP:0031344	biolink:PhenotypicFeature	Pelvic arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the pelvis.		hp.json		http://purl.obolibrary.org/obo/HP_0031344		
UBERON:0014668	biolink:AnatomicalEntity	distal interphalangeal joint of manual digit 2		FMA:35334	hp.json	distal interphalangeal joint of manual digit II|distal interphalangeal joint of index finger	http://purl.obolibrary.org/obo/UBERON_0014668		pheno_slim
HP:0031345	biolink:PhenotypicFeature	Colonic arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the colon.		hp.json		http://purl.obolibrary.org/obo/HP_0031345		
HP:0031340	biolink:PhenotypicFeature	Abnormal lysosomal morphology	A structural anomaly of lysosomes, membrane-enclosed organelles that contain an array of enzymes capable of catabolizing proteins, nucleic acids, carbohydrates, and lipids.		hp.json		http://purl.obolibrary.org/obo/HP_0031340		
HP:0031341	biolink:PhenotypicFeature	Gastric arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the stomach.		hp.json		http://purl.obolibrary.org/obo/HP_0031341		
PATO:0000440	biolink:NamedThing	regular spatial pattern	A pattern quality inhering in a bearer by virtue of the bearer's having a repeatable or predictable placement.		hp.json		http://purl.obolibrary.org/obo/PATO_0000440		relational_slim|value_slim|mpath_slim
HP:0031346	biolink:PhenotypicFeature	Rectal arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the rectum.		hp.json		http://purl.obolibrary.org/obo/HP_0031346		
HP:0031347	biolink:PhenotypicFeature	Uterine arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the uterus.		hp.json		http://purl.obolibrary.org/obo/HP_0031347		
HP:0031348	biolink:PhenotypicFeature	Dextrotransposition of the great arteries	A type of transposition of the great arteries (TGA) in which aorta is in front of and primarily to the right of the pulmonary artery. This is the most common kind of TGA.	Fyler:0700|Fyler:700	hp.json	D-TGA|D-loop transposition of the great arteries	http://purl.obolibrary.org/obo/HP_0031348		
HP:0031349	biolink:PhenotypicFeature	Levotransposition of the great arteries	A type of transposition of the great arteries (TGA) in which aorta is in front of and primarily to the left of the pulmonary artery.		hp.json	L-TGA	http://purl.obolibrary.org/obo/HP_0031349		
UBERON:0000025	biolink:AnatomicalEntity	tube	Any hollow cylindrical anatomical structure containing a lumen through which substances are transported.	galen:Tube	hp.json	duct|anatomical tube	http://purl.obolibrary.org/obo/UBERON_0000025		
UBERON:0000026	biolink:AnatomicalEntity	appendage	Major subdivision of an organism that protrudes from the body[DOS, CARO].	NCIT:C61460|BILA:0000018|OpenCyc:Mx4rvViC-JwpEbGdrcN5Y29ycA|MAT:0000023|EV:0100155|UMLS:C0598782|FBbt:00007000|XAO:0000218|CARO:0010003|MIAA:0000023|Wikipedia:Appendage|MESH:D005121|EMAPA:37283|BTO:0001492|VSAO:0000075|EHDAA2:0003193|HAO:0000144|AEO:0000193|EFO:0000799	hp.json	extremitaet|extremity|limbs/digits/tail|appendages	http://purl.obolibrary.org/obo/UBERON_0000026		pheno_slim|efo_slim|uberon_slim
UBERON:0000020	biolink:AnatomicalEntity	sense organ	An organ that is capable of transducing sensory stimulus to the nervous system.	EMAPA:35955|BTO:0000202|BSA:0000121|UMLS:C0935626|GAID:63|HAO:0000930|MA:0000017|EHDAA2:0001824|SCTID:244485009|MESH:D012679|WBbt:0006929|EHDAA:500|AEO:0000094|NCIT:C33224|CALOHA:TS-2043|VHOG:0001407|FBbt:00005155	hp.json	sensor|sensillum|Sinnesorgan|sense organ system organ|sensory system organ|sensory organ system organ|sensory organ|organ of sensory system|organ of sense organ system|organ of sensory organ system	http://purl.obolibrary.org/obo/UBERON_0000020		uberon_slim
UBERON:0002682	biolink:AnatomicalEntity	abducens nucleus	Nucleus located beneath the floor of the 4th ventricle in the pontine tegmentum, containing motor neurons innervating the lateral rectus muscle of the eye (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 533).	MBA:653|UMLS:C0152407|MESH:D065827|EHDAA2:0004310|ZFA:0000713|UMLS:C0152407|EMAPA:35105|DHBA:12418|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=585|NCIT:C12836|TAO:0000713|BAMS:6|BIRNLEX:1366|HBA:9136|BM:Pons-VI|DMBA:17279|FMA:54504|MA:0001010|EV:0100266|BAMS:VI	hp.json	abducens motor nuclei|abducens VI nucleus|nucleus of abducens nerve (VI)|nucleus of abducens nerve|nucleus nervi abducentis|abducent nucleus|nucleus abducens|sixth cranial nerve nucleus|nucleus nervi abducentis|abducens motor nucleus|nVI|abducens nerve nucleus|abducens nucleus proper|motor nucleus VI	http://purl.obolibrary.org/obo/UBERON_0002682		uberon_slim|vertebrate_core
UBERON:0000021	biolink:AnatomicalEntity	cutaneous appendage	Anatomical projection that protrudes from the skin. Examples: hair, nail, feather, claw, hoof, horn, wattle, spur, beak, antler, bristle and some scales.	FMA:71012|CALOHA:TS-0051	hp.json	epidermal appendage|skin appendage|epidermal growth	http://purl.obolibrary.org/obo/UBERON_0000021		uberon_slim
GO:1902904	biolink:BiologicalProcess	negative regulation of supramolecular fiber organization	Any process that stops, prevents or reduces the frequency, rate or extent of fibril organization.		hp.json	inhibition of fibril organisation|down regulation of fibril organisation|down-regulation of fibril organization|downregulation of fibril organisation|inhibition of fibril organization|down regulation of fibril organization|downregulation of fibril organization|negative regulation of fibril organisation|down-regulation of fibril organisation	http://purl.obolibrary.org/obo/GO_1902904		
GO:1902905	biolink:BiologicalProcess	positive regulation of supramolecular fiber organization	Any process that activates or increases the frequency, rate or extent of supramolecular fiber organization.		hp.json	up regulation of fibril organization|upregulation of fibril organization|up-regulation of fibril organisation|activation of fibril organisation|up regulation of fibril organisation|positive regulation of fibril organisation|up-regulation of fibril organization|activation of fibril organization|upregulation of fibril organisation	http://purl.obolibrary.org/obo/GO_1902905		
UBERON:0000006	biolink:AnatomicalEntity	islet of Langerhans	The clusters of hormone-producing cells that are scattered throughout the pancreas.	EFO:0000856|UMLS:C0022131|MESH:D007515|VHOG:0000646|MAT:0000076|EV:0100130|BTO:0000991|NCIT:C12608|CALOHA:TS-0741|MIAA:0000076|XAO:0000159|MA:0000127|AAO:0010406|FMA:16016|GAID:324|EMAPA:32927	hp.json	islets of Langerhans|pancreatic islet|pancreatic insula|island of pancreas|island of Langerhans	http://purl.obolibrary.org/obo/UBERON_0000006		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0000007	biolink:AnatomicalEntity	pituitary gland	The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands [GO]. An endocrine gland located ventral to the diencephalon and derived from mixed neuroectodermal and non neuroectodermal origin [ZFIN].	BTO:0001073|AAO:0010536|EFO:0000857|BIRNLEX:1353|UMLS:C0032005|MA:0000176|NCIT:C12399|EHDAA:4477|FMA:13889|MAT:0000077|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=399|OpenCyc:Mx4rv6NQYJwpEbGdrcN5Y29ycA|HBA:4634|BAMS:PIT|EV:0100132|EMAPA:35998|BAMS:Pit|EHDAA2:0001471|DHBA:10505|CALOHA:TS-0798|EHDAA:2183|MESH:D010902|ZFA:0000118|MIAA:0000077|XAO:0000017|BM:Die-Hy-HY|GAID:457|VHOG:0000143|TAO:0000118|UMLS:C0032005	hp.json	glandula pituitaria|pituitary|hypophysis|hypophysis cerebri|pituitary body|Hp	http://purl.obolibrary.org/obo/UBERON_0000007		vertebrate_core|organ_slim|pheno_slim|efo_slim|uberon_slim
GO:1902903	biolink:BiologicalProcess	regulation of supramolecular fiber organization	Any process that modulates the frequency, rate or extent of supramolecular fiber organization.		hp.json	regulation of fibril organisation	http://purl.obolibrary.org/obo/GO_1902903		
UBERON:0000009	biolink:AnatomicalEntity	submucosa	A layer of dense irregular connective tissue that lines organs and supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle. [WP,unvetted].	Wikipedia:Submucosa|FMA:85392|FMA:85391|SCTID:68439008|BTO:0002107|UMLS:C0225344|NCIT:C13167	hp.json	tela submucosa|submucosa of region of organ|submucosa of organ|tunica submucosa|region of submucosa|submucous layer|organ submucosa	http://purl.obolibrary.org/obo/UBERON_0000009		pheno_slim|uberon_slim
HP:0031353	biolink:PhenotypicFeature	Otitis media with effusion	Otitis media characterized by thick or sticky fluid behind the tympanic membrane.		hp.json	Fluid behind eardrum	http://purl.obolibrary.org/obo/HP_0031353		
HP:0031354	biolink:PhenotypicFeature	Sleep onset insomnia	Difficulty initiating sleep, that is, increased sleep onset latency.		hp.json	Difficulty falling asleep	http://purl.obolibrary.org/obo/HP_0031354		
HP:0031355	biolink:PhenotypicFeature	Maintenance insomnia	Abnormal difficulty in staying asleep. Affected individuals tend to wake up at night and have difficulty returning to sleep.		hp.json	Waking up several times during the night	http://purl.obolibrary.org/obo/HP_0031355		
HP:0031356	biolink:PhenotypicFeature	Terminal insomnia	A type of insomnia characterized by waking up (too) early in the morning.		hp.json	Late insomnia	http://purl.obolibrary.org/obo/HP_0031356		
HP:0031350	biolink:PhenotypicFeature	Cardiac sarcoma	A malignant soft tissue neoplasm that arises from the heart.		hp.json		http://purl.obolibrary.org/obo/HP_0031350		
HP:0031351	biolink:PhenotypicFeature	Calcified amorphous tumor of the heart	A non-neoplastic cardiac tumor characterized by calcification and eosinophilic amorphous material in the background of dense collagenous fibrous tissue.		hp.json	Calcified amorphous tumour of the heart	http://purl.obolibrary.org/obo/HP_0031351		
HP:0031352	biolink:PhenotypicFeature	Chest tightness	An unpleasant sensation of tightness or pressure in the chest.		hp.json	Tightness of chest|Chest distress|Tightness in chest	http://purl.obolibrary.org/obo/HP_0031352		
CHEBI:35469	biolink:ChemicalSubstance	antidepressant	Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.		hp.json	thymoleptic drugs|thymoanaleptics|antidepressants|antidepressant drugs|thymoleptics	http://purl.obolibrary.org/obo/CHEBI_35469		3_STAR
HP:0031357	biolink:PhenotypicFeature	Glomeruloid hemangioma	A histologically distinctive, cutaneous, benign vascular tumor that is characterized by a solitary or multiple blue-red papules and histologically resembles renal glomeruli.		hp.json		http://purl.obolibrary.org/obo/HP_0031357		
HP:0031358	biolink:PhenotypicFeature	Vegetative state	Absence of wakefulness and conscience, but (in contrast to coma) with involuntary opening of the eyes and movements (such as teeth grinding, yawning, or thrashing of the extremities).		hp.json		http://purl.obolibrary.org/obo/HP_0031358		
GO:0000819	biolink:BiologicalProcess	sister chromatid segregation	The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.		hp.json		http://purl.obolibrary.org/obo/GO_0000819		
HP:0031359	biolink:PhenotypicFeature	Cutaneous sclerotic plaque	A solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter that is characterized by hardening (sclerosis) of the affected skin area (related to collagen thickening).		hp.json		http://purl.obolibrary.org/obo/HP_0031359		
UBERON:0014649	biolink:AnatomicalEntity	white matter of medulla oblongata	A white matter that is part of a medulla oblongata.	BIRNLEX:1024|BAMS:mw|FMA:83944|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=778|BIRNLEX:1414	hp.json	white matter of medulla|white substance of medulla|substantia alba medullae oblongatae|medullary white matter	http://purl.obolibrary.org/obo/UBERON_0014649		
UBERON:0000013	biolink:AnatomicalEntity	sympathetic nervous system	The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter [GO].	EHDAA2:0001971|Wikipedia:Sympathetic_nervous_system|NCIT:C12795|AAO:0010487|BTO:0001832|UMLS:C0039044|SCTID:362484004|MESH:D013564|CALOHA:TS-2050|FMA:9906|UMLS:C1269646|BIRNLEX:2516|EFO:0000893|MIAA:0000100|EMAPA:16985|GAID:710|EHDAA:3769|VHOG:0000384|MA:0000225|ZFA:0001576|UMLS:C0039044|TAO:0001576	hp.json	pars sympathica divisionis autonomici systematis nervosi|sympathetic nervous system|pars sympathica divisionis autonomici systematis nervosi|pars sympathica divisionis autonomici systematis nervosi|sympathetic part of autonomic division of nervous system	http://purl.obolibrary.org/obo/UBERON_0000013		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0000014	biolink:AnatomicalEntity	zone of skin	Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.	MA:0000151|SCTID:20795001|OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA|EHDAA:6530|MAT:0000284|EV:0100152|GAID:933|FMA:86166|VHOG:0000860|EMAPA:17525|MIAA:0000284|Wikipedia:Skin|MESH:D012867|EHDAA2:0001844	hp.json	region of skin|skin|skin region|skin zone|portion of skin	http://purl.obolibrary.org/obo/UBERON_0000014		pheno_slim
UBERON:0000015	biolink:AnatomicalEntity	non-material anatomical boundary	A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures.	AEO:0000192|FMA:50705|CARO:0000010	hp.json	anatomical boundary	http://purl.obolibrary.org/obo/UBERON_0000015		upper_level
UBERON:0000016	biolink:AnatomicalEntity	endocrine pancreas	The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin.	MA:0001582|EMAPA:35305|NCIT:C32509|ZFA:0001260|VHOG:0000049|EFO:0002542|BTO:0000650|TAO:0001260|CALOHA:TS-1302|FMA:16018|EV:0100129	hp.json	pars endocrina pancreatis|endocrine part of pancreas|endocrine pancreas|islets of Langerhans part of pancreas	http://purl.obolibrary.org/obo/UBERON_0000016		organ_slim|pheno_slim|human_reference_atlas|efo_slim|uberon_slim|vertebrate_core
UBERON:0000010	biolink:AnatomicalEntity	peripheral nervous system	A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.	EHDAA:2893|NCIT:C12465|BTO:0001028|TAO:0000142|GAID:715|FBbt:00005098|EFO:0000891|MA:0000218|FMA:9903|VHOG:0000399|BAMS:PNS|EMAPA:16665|AAO:0000429|UMLS:C0206417|CALOHA:TS-0808|MAT:0000338|XAO:0000178|SCTID:362292005|BIRNLEX:1111|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=3232|UMLS:C0206417|Wikipedia:Peripheral_nervous_system|EHDAA2:0001445|EV:0100335|BILA:0000081|UMLS:C1305921|MESH:D017933|MIAA:0000338|ZFA:0000142	hp.json	pars peripherica|PNS|systema nervosum periphericum|systema nervosum periphericum|pars peripherica	http://purl.obolibrary.org/obo/UBERON_0000010		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|cumbo|vertebrate_core
UBERON:0000011	biolink:AnatomicalEntity	parasympathetic nervous system	The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia[GO].	BTO:0001833|AAO:0010488|TAO:0001575|GAID:708|Wikipedia:Parasympathetic_nervous_system|UMLS:C0030510|SCTID:362496006|MAT:0000101|MESH:D010275|EFO:0000894|CALOHA:TS-2094|BIRNLEX:2517|VHOG:0000755|FMA:9907|UMLS:C0030510|EMAPA:17270|EHDA:10096|MIAA:0000101|ZFA:0001575|MA:0000223|EHDAA2:0001402|EHDAA:4655|NCIT:C12764|UMLS:C1305770	hp.json	PNS - parasympathetic|pars parasympathica divisionis autonomici systematis nervosi|parasympathetic part of autonomic division of nervous system|pars parasympathica divisionis autonomici systematis nervosi|pars parasympathica divisionis autonomici systematis nervosi	http://purl.obolibrary.org/obo/UBERON_0000011		pheno_slim|efo_slim|uberon_slim|vertebrate_core
GO:1902908	biolink:BiologicalProcess	regulation of melanosome transport	Any process that modulates the frequency, rate or extent of melanosome transport.		hp.json		http://purl.obolibrary.org/obo/GO_1902908		
UBERON:0002673	biolink:AnatomicalEntity	vestibular nuclear complex	Nuclear complex containing the vestibular nuclei.	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=714|EV:0100254|BAMS:VNC|BAMS:Ve|BTO:0004368|BIRNLEX:1337|BM:Me-VS|GAID:602|MESH:D014726|HBA:9697|FMA:72239|UMLS:C0042600|CALOHA:TS-2078|MBA:701	hp.json	vestibular nuclei|nuclei vestibulares|vestibular nucleus|vestibular nuclei in medulla oblongata|nuclei vestibulares in medulla oblongata	http://purl.obolibrary.org/obo/UBERON_0002673		uberon_slim
GO:1902909	biolink:BiologicalProcess	negative regulation of melanosome transport	Any process that stops, prevents or reduces the frequency, rate or extent of melanosome transport.		hp.json	downregulation of melanosome transport|down regulation of melanosome transport|inhibition of melanosome transport|down-regulation of melanosome transport	http://purl.obolibrary.org/obo/GO_1902909		
UBERON:0000012	biolink:AnatomicalEntity	somatic nervous system	Part of peripheral nervous system that includes the somatic parts of the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.	MAT:0000099|EFO:0000892|FMA:9904|NLXANAT:100301|MIAA:0000099|Wikipedia:Somatic_nervous_system|MA:0002850	hp.json	PNS - somatic|somatic nervous system, somatic division|somatic part of peripheral nervous system|somatic peripheral nervous system	http://purl.obolibrary.org/obo/UBERON_0000012		pheno_slim|uberon_slim
GO:1902913	biolink:BiologicalProcess	positive regulation of neuroepithelial cell differentiation	Any process that activates or increases the frequency, rate or extent of neuroepithelial cell differentiation.		hp.json	up regulation of neuroepithelial cell differentiation|activation of neuroepithelial cell differentiation|up-regulation of neuroepithelial cell differentiation|upregulation of neuroepithelial cell differentiation	http://purl.obolibrary.org/obo/GO_1902913		
GO:0048844	biolink:BiologicalProcess	artery morphogenesis	The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs.		hp.json	arteriogenesis|arterial morphogenesis	http://purl.obolibrary.org/obo/GO_0048844		
GO:0048845	biolink:BiologicalProcess	venous blood vessel morphogenesis	The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart.		hp.json	vein morphogenesis|venous morphogenesis	http://purl.obolibrary.org/obo/GO_0048845		
HP:0031364	biolink:PhenotypicFeature	Ecchymosis	A purpuric lesion that is larger than 1 cm in diameter.		hp.json	Ecchymoses	http://purl.obolibrary.org/obo/HP_0031364		
HP:0031365	biolink:PhenotypicFeature	Macular purpura	Purpura that is flat (non-palpable, not raised).		hp.json	Flat purpura	http://purl.obolibrary.org/obo/HP_0031365		
GO:1902910	biolink:BiologicalProcess	positive regulation of melanosome transport	Any process that activates or increases the frequency, rate or extent of melanosome transport.		hp.json	upregulation of melanosome transport|up regulation of melanosome transport|up-regulation of melanosome transport|activation of melanosome transport	http://purl.obolibrary.org/obo/GO_1902910		
HP:0031366	biolink:PhenotypicFeature	Palate neoplasm	A neoplasm that affects the hard palate, soft palate, or uvula.		hp.json		http://purl.obolibrary.org/obo/HP_0031366		
PATO:0000467	biolink:NamedThing	present	A quality inhering in a bearer by virtue of the bearer's existence.		hp.json	present in organism	http://purl.obolibrary.org/obo/PATO_0000467		value_slim|absent_slim
HP:0031367	biolink:PhenotypicFeature	Metaphyseal striations	Longitudinal densities on radiographs located in a metaphysis (the narrow region of a long bone between the epiphysis and the diaphysis).		hp.json	Striated metaphysis	http://purl.obolibrary.org/obo/HP_0031367		
HP:0031360	biolink:PhenotypicFeature	Yellow skin plaque	A solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter and that has a yellow color.		hp.json		http://purl.obolibrary.org/obo/HP_0031360		
HP:0031361	biolink:PhenotypicFeature	Zebra bodies	Intralysosomal, osmiophilic, lamellated and sometimes concentric cytoplasmic inclusions comprised of broad transversely-stacked myelinoid membranes and said to resemble a zebra in electron microscopic images.		hp.json		http://purl.obolibrary.org/obo/HP_0031361		
HP:0031362	biolink:PhenotypicFeature	obsolete Sex-limited autosomal recessive inheritance			hp.json		http://purl.obolibrary.org/obo/HP_0031362		
HP:0031363	biolink:PhenotypicFeature	Palpable purpura	A type of purpura in which the lesions are raised (and can therefore be appreciated upon palpation).		hp.json		http://purl.obolibrary.org/obo/HP_0031363		
PATO:0000460	biolink:NamedThing	abnormal	A quality inhering in a bearer by virtue of the bearer's deviation from normal or average.		hp.json	defective|aberrant|atypia|atypical	http://purl.obolibrary.org/obo/PATO_0000460		mpath_slim|abnormal_slim|value_slim
PATO:0000462	biolink:NamedThing	absent	A quality denoting the lack of an entity.		hp.json	absent from organism|absence	http://purl.obolibrary.org/obo/PATO_0000462		absent_slim|mpath_slim|value_slim
UBERON:0014636	biolink:AnatomicalEntity	thoracic spinal cord gray matter	A gray matter of spinal cord that is part of a thoracic spinal cord.	UMLS:C0228627|BIRNLEX:980|SCTID:362441000	hp.json	thoracic spinal cord gray matter	http://purl.obolibrary.org/obo/UBERON_0014636		
HP:0031368	biolink:PhenotypicFeature	Intestinal perforation	A hole (perforation) in the wall of the intestine.		hp.json		http://purl.obolibrary.org/obo/HP_0031368		
PATO:0000461	biolink:NamedThing	normal	A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average.		hp.json	average	http://purl.obolibrary.org/obo/PATO_0000461		mpath_slim|abnormal_slim|value_slim
HP:0031369	biolink:PhenotypicFeature	Colon perforation	A hole (perforation) in the wall of the colon.		hp.json	Perforation of the colon	http://purl.obolibrary.org/obo/HP_0031369		
UBERON:0014637	biolink:AnatomicalEntity	thoracic spinal cord white matter	A white matter of spinal cord that is part of a thoracic spinal cord.	UMLS:C0228633|BIRNLEX:999|UMLS:C1288557|SCTID:367881009	hp.json	thoracic spinal cord white matter	http://purl.obolibrary.org/obo/UBERON_0014637		
UBERON:0014639	biolink:AnatomicalEntity	frontal sulcus	A sulcus of brain that is part of a frontal cortex.	UMLS:C0459388|HBA:9354|NCIT:C32639	hp.json	frontal lobe sulci|frontal lobe sulcus	http://purl.obolibrary.org/obo/UBERON_0014639		
UBERON:0000002	biolink:AnatomicalEntity	uterine cervix	Lower, narrow portion of the uterus where it joins with the top end of the vagina.	EV:0100114|galen:CervixUteri|NCIT:C12311|BTO:0002249|EMAPA:29927|MA:0000392|VHOG:0001359|MESH:D002584|BTO:0001421|MAT:0000292|CALOHA:TS-0134|EFO:0000979|OpenCyc:Mx4rvVipEJwpEbGdrcN5Y29ycA|UMLS:C0007874|FMA:17740|GAID:376	hp.json	cervix|canalis cervicis uteri|neck of uterus|uterine cervix|cervical canal|cervix uteri|cervix of uterus|caudal segment of uterus|cervical canal of uterus	http://purl.obolibrary.org/obo/UBERON_0000002		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0000003	biolink:AnatomicalEntity	naris	Orifice of the olfactory system. The naris is the route by which odorants enter the olfactory system[MAH].	EHDAA:9083|EHDAA2:0001225|galen:Naris|AAO:0000311|MA:0000282|EMAPA:17847|VHOG:0000663	hp.json		http://purl.obolibrary.org/obo/UBERON_0000003		uberon_slim|vertebrate_core
UBERON:0000004	biolink:AnatomicalEntity	nose	The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity.	FMA:46472|MAT:0000139|TAO:0000047|EV:0100037|MIAA:0000139|BTO:0000840|UMLS:C0028429|EHDAA2:0001274|GAID:77|MA:0000281|OpenCyc:Mx4rvViCbJwpEbGdrcN5Y29ycA|MESH:D009666|EV:0100370|galen:Nose|CALOHA:TS-2037|EHDAA:1502|NCIT:C12756|EMAPA:16542|ZFA:0000047	hp.json	peripheral olfactory organ|nose|olfactory apparatus|nasal sac|nasus|proboscis	http://purl.obolibrary.org/obo/UBERON_0000004		pheno_slim|efo_slim|uberon_slim|major_organ|vertebrate_core
UBERON:0000005	biolink:AnatomicalEntity	chemosensory organ		FBbt:00005157	hp.json	chemosensory sensory organ	http://purl.obolibrary.org/obo/UBERON_0000005		functional_classification|uberon_slim
UBERON:0002663	biolink:AnatomicalEntity	septal nuclear complex	Collection of nerve cells in the medial forebrain lying generally in front of the anterior commissure (Maryann Martone).	MESH:D012686|DHBA:10350|UMLS:C0036687|GAID:637|EHDAA2:0004709|BIRNLEX:1313|EMAPA:35763|MA:0002978|FMA:61845|HBA:13002|BAMS:SptN	hp.json	parolfactory nuclei|septal nuclei|septal nucleus|nuclei septales	http://purl.obolibrary.org/obo/UBERON_0002663		uberon_slim
UBERON:0000000	biolink:AnatomicalEntity	processual entity	An occurrent [span:Occurrent] that exists in time by occurring or happening, has temporal parts and always involves and depends on some entity.		hp.json		http://purl.obolibrary.org/obo/UBERON_0000000		upper_level
GO:0048852	biolink:BiologicalProcess	diencephalon morphogenesis	The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.		hp.json		http://purl.obolibrary.org/obo/GO_0048852		
GO:0048853	biolink:BiologicalProcess	forebrain morphogenesis	The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).		hp.json	prosencephalon morphogenesis	http://purl.obolibrary.org/obo/GO_0048853		
HP:0031370	biolink:PhenotypicFeature	Small intestinal perforation	A hole (perforation) in the wall of the small intestine.		hp.json		http://purl.obolibrary.org/obo/HP_0031370		
GO:0048854	biolink:BiologicalProcess	brain morphogenesis	The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).		hp.json		http://purl.obolibrary.org/obo/GO_0048854		
GO:0048856	biolink:BiologicalProcess	anatomical structure development	The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.		hp.json	development of an anatomical structure	http://purl.obolibrary.org/obo/GO_0048856		goslim_plant|goslim_chembl|goslim_generic
GO:0048857	biolink:BiologicalProcess	neural nucleus development	The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma.		hp.json		http://purl.obolibrary.org/obo/GO_0048857		
HP:0031375	biolink:PhenotypicFeature	Refractory	Applies to a sign or symptom that is difficult to treat or cure.		hp.json		http://purl.obolibrary.org/obo/HP_0031375		
HP:0031377	biolink:PhenotypicFeature	Abnormal cell proliferation	Any abnormality in the multiplication or reproduction of cells, which may result in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/HP_0031377		
HP:0031378	biolink:PhenotypicFeature	Abnormal lymphocyte proliferation	Any abnormality in the multiplication or reproduction of lymphocytes, which results in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/HP_0031378		
HP:0031371	biolink:PhenotypicFeature	Rectal perforation	A hole (perforation) in the wall of the rectum.		hp.json		http://purl.obolibrary.org/obo/HP_0031371		
HP:0031372	biolink:PhenotypicFeature	Cold paresis	Increased muscle weakness upon exposure to cold temperatures.		hp.json		http://purl.obolibrary.org/obo/HP_0031372		
HP:0031373	biolink:PhenotypicFeature	Stiff tongue	Increased rigidity and reduced mobility of the tongue.		hp.json	Tongue stiffness	http://purl.obolibrary.org/obo/HP_0031373		
HP:0031374	biolink:PhenotypicFeature	Ankle weakness	Reduced strength of the muscles that lift or otherwise move the foot at the ankle.		hp.json		http://purl.obolibrary.org/obo/HP_0031374		
CHEBI:84497	biolink:ChemicalSubstance	(omega-1)-hydroxy fatty acid anion	A hydroxy fatty acid anion obtained by deprotonation of the carboxy group of any (omega-1)-hydroxy fatty acid; major species at pH 7.3.		hp.json	an (omega-1)-hydroxy fatty acid|(omega-1)-hydroxy fatty acid anion	http://purl.obolibrary.org/obo/CHEBI_84497		3_STAR
PATO:0000470	biolink:NamedThing	increased amount	An amount which is relatively high.		hp.json	supernumerary|accessory|increased|present in greater numbers in organism|increased number	http://purl.obolibrary.org/obo/PATO_0000470		value_slim
HP:0031379	biolink:PhenotypicFeature	Abnormal T cell proliferation	Any abnormality in the multiplication or reproduction of T cells, which results in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/HP_0031379		
GO:0048858	biolink:BiologicalProcess	cell projection morphogenesis	The process in which the anatomical structures of a cell projection are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0048858		
GO:0048859	biolink:BiologicalProcess	formation of anatomical boundary	The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.		hp.json		http://purl.obolibrary.org/obo/GO_0048859		
CHEBI:35441	biolink:ChemicalSubstance	antiinfective agent	A substance used in the prophylaxis or therapy of infectious diseases.		hp.json	antiinfective drug|antiinfective agents|anti-infective drugs|anti-infective agents	http://purl.obolibrary.org/obo/CHEBI_35441		3_STAR
PATO:0000407	biolink:NamedThing	flat	A quality inhering in a bearer by virtue of the bearer's having a horizontal surface without a slope, tilt, or curvature.		hp.json	plate-like	http://purl.obolibrary.org/obo/PATO_0000407		mpath_slim|cell_quality|value_slim
HP:0033961	biolink:PhenotypicFeature	Cortical radial artery intima/media multilamellation	Myointimal hyperplasia of the inner and middle layer of the cortical radial artery (also known as the interlobular artery) of the kidney, arranged in multiple concentric layers.		hp.json	Multilamellation (onion skinning) within interlobular arterial intima/media|Cortical radial artery intima/media onion skinning	http://purl.obolibrary.org/obo/HP_0033961		
HP:0033960	biolink:PhenotypicFeature	Cortical radial artery intimal mucoid edema	Accumulation of edematous extracellular matrix in the intima of the cortical radial artery (also known as the interlobular artery) of the kidney. This material resembles mucus and stains pale blue on hematoxylin and eosin staining.		hp.json	Intimal mucoid edema within interlobular arterial intima/media	http://purl.obolibrary.org/obo/HP_0033960		
GO:0034219	biolink:BiologicalProcess	carbohydrate transmembrane transport	The process in which a carbohydrate is transported across a membrane.		hp.json	transmembrane carbohydrate transport|carbohydrate membrane transport	http://purl.obolibrary.org/obo/GO_0034219		
HP:0031300	biolink:PhenotypicFeature	Abnormal circulating properdin level	A deviation from the normal concentration of properdin in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031300		
PATO:0000402	biolink:NamedThing	branched	A branchiness quality inhering in a bearer by virtue of the bearer's having branches.		hp.json	ramiform|ramified	http://purl.obolibrary.org/obo/PATO_0000402		value_slim|mpath_slim|cell_quality
HP:0033963	biolink:PhenotypicFeature	Abnormal interlobular vein intima/media morphology	Any structural anomaly of the inner or middle layer of the interlobular veins of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033963		
HP:0031301	biolink:PhenotypicFeature	Peripheral arterial calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall.		hp.json	Peripheral artery calcification	http://purl.obolibrary.org/obo/HP_0031301		
HP:0033962	biolink:PhenotypicFeature	Cortical radial artery medial/intimal granulomatous arteriitis	A type of cortical radial artery medial/intimal arteriitis that is characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries.		hp.json		http://purl.obolibrary.org/obo/HP_0033962		
PATO:0000404	biolink:NamedThing	coiled	A shape quality inhering in a bearer by virtue of the bearer's being curled or wound (especially in concentric rings or spirals).		hp.json	spiral|helical|helix-shaped|helicoid|helicoidal	http://purl.obolibrary.org/obo/PATO_0000404		cell_quality|value_slim|mpath_slim
PATO:0000403	biolink:NamedThing	cleft	A concave quality inhering in a bearer by virtue of the bearer's resembling a groove or fissure.		hp.json		http://purl.obolibrary.org/obo/PATO_0000403		cell_quality|value_slim|mpath_slim
PATO:0000406	biolink:NamedThing	curved	A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend.		hp.json	bowing|curled	http://purl.obolibrary.org/obo/PATO_0000406		cell_quality|value_slim
PATO:0000405	biolink:NamedThing	curled	A shape quality inhering in a bearer by virtue of the bearer's having parallel chains in undulate fashion on the border.		hp.json		http://purl.obolibrary.org/obo/PATO_0000405		cell_quality|value_slim|mpath_slim
HP:0006339	biolink:PhenotypicFeature	Conical mandibular incisor	An abnormal conical morphology of the primary or permanent mandibular incisors.	UMLS:C4280449|UMLS:C4280450|UMLS:C4020818	hp.json	Pointed mandibular incisor|Peg shaped mandibular incisor|Cone shaped lower front tooth|Conoid mandibular incisor|Pointed mandibular incisors|Peg shaped lower front tooth|Lower front shark tooth	http://purl.obolibrary.org/obo/HP_0006339		
HP:0033969	biolink:PhenotypicFeature	Interlobular vein intima/media necrosis	Cell death (necrosis) in the inner or middle layer of the interlobular vein of the kidney.		hp.json	Necrosis within interlobular vein intima/media	http://purl.obolibrary.org/obo/HP_0033969		
HP:0031306	biolink:PhenotypicFeature	Intracranial arterial calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in an artery that is located within the skull (intracranial).		hp.json		http://purl.obolibrary.org/obo/HP_0031306		
GO:0010243	biolink:BiologicalProcess	response to organonitrogen compound	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.		hp.json	response to organic nitrogen	http://purl.obolibrary.org/obo/GO_0010243		
HP:0033968	biolink:PhenotypicFeature	Interlobular vein intima/media granulomatous venulitis	A type of interlobular vein intima/media venulitis that is characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed veins.		hp.json	Granulomatous venulitis within interlobular vein intima/media	http://purl.obolibrary.org/obo/HP_0033968		
HP:0031307	biolink:PhenotypicFeature	Internal carotid artery calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the internal carotid artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031307		
HP:0031308	biolink:PhenotypicFeature	Vertebral artery calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the vertebral artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031308		
HP:0031309	biolink:PhenotypicFeature	Cerebral artery calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a cerebral artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031309		
HP:0006335	biolink:PhenotypicFeature	Persistence of primary teeth	Persistence of the primary teeth beyond the age by which they normally are shed and replaced by the permanent teeth.	SNOMEDCT_US:57650002|UMLS:C0266050	hp.json	Deciduous teeth retention|Retained primary teeth|Persistence of deciduous teeth|Retained baby teeth|Failure to lose baby teeth|Failure to exfoliate deciduous teeth|Retained deciduous teeth|Persistent primary teeth|Delayed loss of baby teeth|Delayed loss of primary teeth|Persistent primary dentition|Failure to exfoliate primary teeth|Delayed loss of deciduous teeth|Persistent deciduous dentition	http://purl.obolibrary.org/obo/HP_0006335		
HP:0031302	biolink:PhenotypicFeature	Lower extremity peripheral arterial calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the leg.		hp.json	Lower extremity peripheral artery calcification	http://purl.obolibrary.org/obo/HP_0031302		
HP:0008998	biolink:PhenotypicFeature	Pectoralis hypoplasia	Underdevelopment of the pectoral muscle.	UMLS:C1846477	hp.json	Underdeveloped pec muscle|Small pec muscle|Hypoplastic pectoral muscle	http://purl.obolibrary.org/obo/HP_0008998		
HP:0033965	biolink:PhenotypicFeature	Interlobular vein intimal mucoid edema	Accumulation of edematous extracellular matrix in the intima of the interlobular vein of the kidney. This material resembles mucus and stains pale blue on hematoxylin and eosin staining.		hp.json	Intimal mucoid edema within interlobular veins	http://purl.obolibrary.org/obo/HP_0033965		
HP:0008997	biolink:PhenotypicFeature	Proximal muscle weakness in upper limbs	A lack of strength of the proximal muscles of the arms.	UMLS:C1866012	hp.json		http://purl.obolibrary.org/obo/HP_0008997		
HP:0031303	biolink:PhenotypicFeature	Femoral arterial calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the femoral artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031303		
HP:0006336	biolink:PhenotypicFeature	Short dental root	Tooth root length more than 2 SD below mean, or subjectively apparently decreased tooth root length.	UMLS:C2678330	hp.json	Underdeveloped tooth roots|Decreased length of tooth roots|Rhizomicry|Dental root hypoplasia|Underdeveloped dental roots|Decreased length of dental roots|Dental root hypotrophy|Root dwarfism|Short dental roots|Short tooth roots	http://purl.obolibrary.org/obo/HP_0006336		
HP:0033964	biolink:PhenotypicFeature	Interlobular intima/media venosclerosis	Thickening of the intima with fibrosis and/or duplication of the elastic lamina in interlobular veins of the kidney.		hp.json	Venosclerosis within interlobular vein intima/media	http://purl.obolibrary.org/obo/HP_0033964		
HP:0006337	biolink:PhenotypicFeature	Premature eruption of permanent teeth	Premature tooth eruption of the permanent dentition.	UMLS:C4021601	hp.json	Early eruption of permanent teeth|Early eruption of adult teeth|Premature eruption of adult teeth|Precocious eruption of secondary teeth|Precocious eruption of secondary dentition	http://purl.obolibrary.org/obo/HP_0006337		hposlim_core
HP:0033967	biolink:PhenotypicFeature	Interlobular vein intima/media venulitis	Inflammation of the interlobular veins of the kidney which may affect only the intima or may be transmural.		hp.json	Venulitis within interlobular vein intima/media	http://purl.obolibrary.org/obo/HP_0033967		
HP:0031304	biolink:PhenotypicFeature	Iliac arterial calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the iliac artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031304		
GO:0009259	biolink:BiologicalProcess	ribonucleotide metabolic process	The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.		hp.json	ribonucleotide metabolism	http://purl.obolibrary.org/obo/GO_0009259		
HP:0031305	biolink:PhenotypicFeature	Tibial arterial calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall of the tibial artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031305		
HP:0006338	biolink:PhenotypicFeature	Malformation of mandibular premolar	An abnormality of the morphology of secondary premolar tooth.	UMLS:C4025061	hp.json	Malformation of lower premolar|Malformation of mandibular bicuspid	http://purl.obolibrary.org/obo/HP_0006338		
HP:0033966	biolink:PhenotypicFeature	Interlobular vein intima/media amyloidosis	Amorphous extracellular substance in the glomerular, interstitial or vascular compartments of the interlobular veins of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy		hp.json	Amyloidosis within interlobular vein intima/media	http://purl.obolibrary.org/obo/HP_0033966		
HP:0008994	biolink:PhenotypicFeature	Proximal muscle weakness in lower limbs	A lack of strength of the proximal muscles of the legs.	UMLS:C1866010	hp.json	Muscle weakness, proximal, lower limbs	http://purl.obolibrary.org/obo/HP_0008994		
HP:0008993	biolink:PhenotypicFeature	Increased intraabdominal fat	An abnormal increase in the amount of intraabdominal fat tissue.	UMLS:C1835390	hp.json		http://purl.obolibrary.org/obo/HP_0008993		
HP:0006332	biolink:PhenotypicFeature	Supernumerary maxillary incisor	The presence of a supernumerary, i.e., extra, maxillary incisor, either the primary maxillary incisor or the permanent maxillary incisor.	UMLS:C4025062	hp.json	Extra upper front tooth	http://purl.obolibrary.org/obo/HP_0006332		
HP:0006333	biolink:PhenotypicFeature	Crowded maxillary incisors	A type of dental misalignment with crowded central incisors, i.e., of maxillary secondary incisor, or of maxillary central primary incisor.	UMLS:C4021602	hp.json	Overlapped maxillary incisors|Crowded upper front teeth|Overlapped upper front teeth|Crowded upper incisors	http://purl.obolibrary.org/obo/HP_0006333		
HP:0006334	biolink:PhenotypicFeature	Hypoplasia of the primary teeth	Developmental hypoplasia of the primary teeth.	UMLS:C1855694	hp.json	Small primary teeth|Decreased size of baby teeth|Underdevelopment of primary teeth|Underdevelopment of milk teeth|Small milk teeth|Decreased size of deciduous teeth|Underdevelopment of baby teeth|Decreased size of primary teeth|Decreased size of milk teeth|Small baby teeth|Hypoplastic deciduous teeth	http://purl.obolibrary.org/obo/HP_0006334		
HP:0006330	biolink:PhenotypicFeature	Rotated maxillary central incisors		UMLS:C4025063	hp.json	Turned upper front teeth|Rotated upper front teeth|Twisted upper front teeth|Rotated upper central incisors	http://purl.obolibrary.org/obo/HP_0006330		
HP:0008991	biolink:PhenotypicFeature	Exercise-induced leg cramps	Sudden and involuntary contractions of one or more muscles of the leg brought on by physical exertion.	UMLS:C4024607	hp.json		http://purl.obolibrary.org/obo/HP_0008991		
CHEBI:142567	biolink:ChemicalSubstance	alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-yl group	A trisaccharide beta-D-glucosyl group obtained by removal of the hydroxy group from the hemiacetal function of alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose. Part of, and the proposed epitope from, alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide (globoside Gb3Cer; globotriosylceramide; CTH).	PMID:33643275|PMID:7691279	hp.json	alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl|Galalpha1-4Galbeta1-4Glcbeta-yl|alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-D-Glc-yl|alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl|Galalpha1-4Galbeta1-4Glcbeta-R|Gala1-4Galb1-4Glcb-yl	http://purl.obolibrary.org/obo/CHEBI_142567		3_STAR
HP:0033972	biolink:PhenotypicFeature	Interlobular vein medial atrophy	Atrophy (wasting, decreased thickness) of the medial layer pf the interlobular veins of the kidney.		hp.json	Medial atrophy within interlobular veins	http://purl.obolibrary.org/obo/HP_0033972		
PATO:0000411	biolink:NamedThing	circular	A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center.		hp.json	round|rounded	http://purl.obolibrary.org/obo/PATO_0000411		value_slim|mpath_slim|cell_quality
HP:0033971	biolink:PhenotypicFeature	Interlobular vein intima/media coagulative necrosis	A type of interlobular vein intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures.		hp.json		http://purl.obolibrary.org/obo/HP_0033971		
HP:0031310	biolink:PhenotypicFeature	Basilar artery calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the basilar artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031310		
HP:0031311	biolink:PhenotypicFeature	Middle cerebral artery calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the middle cerebral artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031311		
HP:0033974	biolink:PhenotypicFeature	Interlobular vein intima/media multilamellation	Myointimal hyperplasia of the inner and middle layer of the interlobular veins of the kidney, arranged in multiple concentric layers.		hp.json	Interlobular vein intima/media onion skinning|Multilamellation (onion skinning) within interlobular vein intima/media	http://purl.obolibrary.org/obo/HP_0033974		
PATO:0000413	biolink:NamedThing	square	A shape quality inhering in a bearer by virtue of the bearer's having an equal-sided rectangular form.		hp.json		http://purl.obolibrary.org/obo/PATO_0000413		value_slim|cell_quality
HP:0033973	biolink:PhenotypicFeature	Interlobular vein medial hypertrophy	Increased thickness of middle layer of the interlobular veins of the kidney.		hp.json	Medial hypertrophy within interlobular veins	http://purl.obolibrary.org/obo/HP_0033973		
HP:0033970	biolink:PhenotypicFeature	Interlobular vein intima/media liquefactive necrosis	A type of interlobular vein intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.		hp.json	Liquefactive necrosis within interlobular vein intima/media	http://purl.obolibrary.org/obo/HP_0033970		
HP:0031317	biolink:PhenotypicFeature	Fatty replacement of ventricular myocardial tissue	Presence of an increased amount of fat tissue within a cardiac ventricle with corresponding reduction of muscle tissue.		hp.json	Fatty infiltration of cardiac ventricle|Intramyocardial fat infiltration	http://purl.obolibrary.org/obo/HP_0031317		
HP:0031318	biolink:PhenotypicFeature	Myofiber disarray	A nonparallel arrangement of cardiac myocytes.		hp.json	Myocardial fiber disarray|Myocardial fibre disarray	http://purl.obolibrary.org/obo/HP_0031318		
HP:0033979	biolink:PhenotypicFeature	Excessive dynamic airway collapse	Excessive anterior displacement of the tracheal and/or bronchial membranous wall.		hp.json	Membranous tracheobronchomalacia	http://purl.obolibrary.org/obo/HP_0033979		
HP:0031319	biolink:PhenotypicFeature	Cardiomyocyte hypertrophy	An increase in cell size, enhanced protein synthesis, and heightened organization of the sarcomere within cardiac myocytes.		hp.json	Myocyte cellular hypertrophy	http://purl.obolibrary.org/obo/HP_0031319		
HP:0031313	biolink:PhenotypicFeature	Abdominal aortic calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in abdominal aorta.		hp.json		http://purl.obolibrary.org/obo/HP_0031313		
HP:0033976	biolink:PhenotypicFeature	Volar fingernail	The presence of an extra nail on the palmar (volar, ventral) surface of the finger.		hp.json	Palmar fingernail|Ventral fingernail	http://purl.obolibrary.org/obo/HP_0033976		
HP:0006346	biolink:PhenotypicFeature	Screwdriver-shaped incisors	An abnormality of morphology of the incisor tooth in which the tooth is shaped like a screwdriver blade, i.e., having a rhomboid shape.	UMLS:C4025058	hp.json	Screwdriver shaped front teeth|Screwdriver-shaped incisors	http://purl.obolibrary.org/obo/HP_0006346		
HP:0031314	biolink:PhenotypicFeature	Carotid artery calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in a carotid artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031314		
HP:0033975	biolink:PhenotypicFeature	Absent second fingernail	Absence of the fingernail of the index (second) finger.		hp.json		http://purl.obolibrary.org/obo/HP_0033975		
HP:0006347	biolink:PhenotypicFeature	Microdontia of primary teeth	Decreased size of the primary teeth.	UMLS:C1856203|UMLS:C1855694	hp.json	Decreased size of primary tooth|Small deciduous teeth|Decreased width of deciduous teeth|Microdontia of deciduous teeth|Decreased width of milk teeth|Decreased width of primary tooth|Decreased width of baby teeth	http://purl.obolibrary.org/obo/HP_0006347		
HP:0033978	biolink:PhenotypicFeature	Reduced beta-hexosaminidase activity	Diminished activity of the enzyme beta-hexosaminidase in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033978		
HP:0031315	biolink:PhenotypicFeature	External carotid artery calcification	An accumulation of calcium and phosphate in arteries with mineral deposits in the intimal or medial layer of the vessel wall in the external carotid artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031315		
HP:0031316	biolink:PhenotypicFeature	Abnormal ventricular myocardium morphology	A structural anomaly of the muscle layer of the heart wall of a cardiac ventricle.		hp.json		http://purl.obolibrary.org/obo/HP_0031316		
HP:0006349	biolink:PhenotypicFeature	Agenesis of permanent teeth	A congenital defect characterized by the absence of one or more permanent teeth, including oligodontia, hypodontia, and adontia of the of permanent teeth.	SNOMEDCT_US:234948008|UMLS:C1290511|SNOMEDCT_US:109444001|MSH:C563203|UMLS:C0457756	hp.json	Missing teeth|Failure of development of secondary teeth|Agenesis of secondary dentition|Absence of permanent teeth|Absent permanent teeth|Agenesis of permanent dentition|Failure of development of permanent teeth	http://purl.obolibrary.org/obo/HP_0006349		
GO:0010256	biolink:BiologicalProcess	endomembrane system organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.		hp.json	endomembrane system organisation|endomembrane organization	http://purl.obolibrary.org/obo/GO_0010256		goslim_drosophila
HP:0033977	biolink:PhenotypicFeature	Talar aplasia	Absent talus owing to a congenital defect.		hp.json	Absent talus|Talus aplasia	http://purl.obolibrary.org/obo/HP_0033977		
HP:0006342	biolink:PhenotypicFeature	Peg-shaped maxillary lateral incisors	A tooth crown with its mesial and distal sides converging or tapering toward the incisal edge causing severe reduction of mesiodistal diameter	UMLS:C4025060	hp.json	Peg shaped upper lateral incisors|Peg-shaped tooth|Pointed upper lateral incisors|Cone shaped upper lateral incisors|Conical maxillary lateral incisors|Conoid upper lateral incisors|Peg laterals	http://purl.obolibrary.org/obo/HP_0006342		
HP:0006344	biolink:PhenotypicFeature	Abnormality of primary molar morphology	An abnormality of morphology of primary molar.	UMLS:C4025059	hp.json	Abnormality of deciduous molar morphology|Abnormality of shape of baby molar|Abnormality of shape of primary molar	http://purl.obolibrary.org/obo/HP_0006344		
HP:0033983	biolink:PhenotypicFeature	Decreased circulating apolipoprotein C-II concentration	Reduced concentration of apolipoprotein C-II in the blood circulation.		hp.json	Decreased plasma apolipoprotein C-II	http://purl.obolibrary.org/obo/HP_0033983		
HP:0031320	biolink:PhenotypicFeature	Cardiomyocyte mitochondrial proliferation	An abnormal increase in the number of mitochondria per cardiac myocyte.		hp.json		http://purl.obolibrary.org/obo/HP_0031320		
HP:0033982	biolink:PhenotypicFeature	Celiac artery dissection	A separation (dissection) of the layers of the celiac artery wall.		hp.json		http://purl.obolibrary.org/obo/HP_0033982		
HP:0031321	biolink:PhenotypicFeature	Myocardial immune cell infiltration	An increase in the number of immune cells in myocardial tissue (which can be assumed to have migrated into the myocardium).		hp.json		http://purl.obolibrary.org/obo/HP_0031321		
HP:0031322	biolink:PhenotypicFeature	Myocardial lymphocytic infiltration	An increase in the number of lymphocytes in myocardial tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0031322		
HP:0033985	biolink:PhenotypicFeature	Elongated femoral neck	Increased length of the neck of the femur.		hp.json	Long femoral neck	http://purl.obolibrary.org/obo/HP_0033985		
HP:0033984	biolink:PhenotypicFeature	Increased urinary 8-oxo-7,8-dihydroguanosine level	An elevated amount of 8-oxo-7,8-dihydroguanosine in the urine.		hp.json	Increased urine 8-oxo-7,8-dihydroguanosine|Increased urinary 8-oxo-7,8-dihydroguanosine|Increased urine 8-oxo-GMP|Increased urinary 8-oxo-Gsn level	http://purl.obolibrary.org/obo/HP_0033984		
HP:0031323	biolink:PhenotypicFeature	Myocardial eosinophilic infiltration	An increase in the number of eosinophils in myocardial tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0031323		
HP:0033981	biolink:PhenotypicFeature	Vertebral artery tortuosity	Abnormal tortuous (i.e., twisted) form of the vertebral arteries.		hp.json	Tortuous vertebral arteries	http://purl.obolibrary.org/obo/HP_0033981		
HP:0033980	biolink:PhenotypicFeature	Paroxysmal tonic upgaze	Recurrent episodes of sustained upward deviation of the eyes and incomplete downward saccades, and normal horizontal eye movements without impairment of consciousness.		hp.json		http://purl.obolibrary.org/obo/HP_0033980		
PATO:0000427	biolink:NamedThing	recurrent	A quality of a single process inhering in a bearer by virtue of the bearer's occurring or appearing again or repeatedly.		hp.json		http://purl.obolibrary.org/obo/PATO_0000427		hpo_slim|value_slim|mpath_slim
HP:0031328	biolink:PhenotypicFeature	Perivascular cardiac fibrosis	A type of myocardial fibrosis characterized by excessive diffuse collagen accumulation concentrated in perivascular spaces.		hp.json		http://purl.obolibrary.org/obo/HP_0031328		
HP:0031329	biolink:PhenotypicFeature	Interstitial cardiac fibrosis	A type of myocardial fibrosis characterized by excessive diffuse collagen accumulation concentrated in interstitial spaces.		hp.json		http://purl.obolibrary.org/obo/HP_0031329		
HP:0006313	biolink:PhenotypicFeature	Widely spaced primary teeth	Increased space between the primary teeth. Note this phenotype should be distinguished from increased space due purely to microdontia.	UMLS:C4021603	hp.json	Generalised spacing of primary teeth|Widely spaced milk teeth|Widely spaced deciduous teeth|Widely spaced baby teeth|Wide gaps between primary teeth|Wide gaps between baby teeth|Generalized spacing of primary teeth	http://purl.obolibrary.org/obo/HP_0006313		
GO:0009235	biolink:BiologicalProcess	cobalamin metabolic process	The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.		hp.json	vitamin B12 metabolism|vitamin B12 reduction|vitamin B12 metabolic process|cobalamin metabolism	http://purl.obolibrary.org/obo/GO_0009235		
HP:0031324	biolink:PhenotypicFeature	Myocardial multinucleated giant cells	The presence of extremely large cells with multiple nuclei. The so-called giant cells are thought to be of macrophage origin.		hp.json		http://purl.obolibrary.org/obo/HP_0031324		
HP:0033987	biolink:PhenotypicFeature	Phosphaturic mesenchymal tumor	A rare, endocrine active tumor that causes severe renal phosphate wasting, which in turn can lead to critical osteomalacia. Phosphaturic mesenchymal tumors (PMTs) are typically small and mostly benign tumors producing fibroblast growth factor 23 (FGF-23). FGF-23 lowers the expression of sodium/phosphate cotransporters, which are the primary transport proteins responsible for phosphate reabsorption in the kidneys. The paraneoplastic overproduction of FGF-23 lowers reabsorption of phosphate and causes severe paraneoplastic renal phosphate wasting and hypophosphatemia. FGF-23 also affects vitamin D levels by lowering 25-hydroxyvitamin D 1-alpha-hydroxylase in the proximal renal tubules and by increasing the expression of vitamin D 24-hydroxylase, a mitochondrial enzyme responsible for inactivating vitamin D metabolites.		hp.json		http://purl.obolibrary.org/obo/HP_0033987		
HP:0031325	biolink:PhenotypicFeature	Myocardial granulomatous infiltrates	The presence of multiple granulomata (small nodular inflammatory lesions containing grouped mononuclear phagocytes) in the myocardium.		hp.json		http://purl.obolibrary.org/obo/HP_0031325		
HP:0033986	biolink:PhenotypicFeature	Tortuous lymphatic vessels	The presence of an increased number of twists and turns of lymphatic vessels.		hp.json	Tortuous lymphatics	http://purl.obolibrary.org/obo/HP_0033986		
HP:0006315	biolink:PhenotypicFeature	Solitary median maxillary central incisor	A single maxillary central incisor positioned in the midline with morphological symmetry of the crown and bordered by lateral incisors.	UMLS:C1840235|MSH:C537342|SNOMEDCT_US:707609006	hp.json	Only one upper front tooth|Single median incisor|Single midline maxillary incisor|Single maxillary central incisor|Single central upper incisor|Solitary median maxillary central incisor|Single central incisor|Solitary midline maxillary central incisor|Single midline upper front tooth|Solitary median maxillary central incisor syndrome|Single median maxillary incisor	http://purl.obolibrary.org/obo/HP_0006315		hposlim_core
HP:0031326	biolink:PhenotypicFeature	Monoclonal light chain cardiac amyloidosis	A type of cardiac amyloidosis related to deposition of an immunoglobulin light chain. The current gold standard of amyloid typing is to determine the precursor protein using laser microdissection mass spectrometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031326		
HP:0033989	biolink:PhenotypicFeature	Hippocampal microinfarct	An infarct located in the structure of the cerebrum involved with memory storage and spatial navigation that can only be observed microscopically.		hp.json		http://purl.obolibrary.org/obo/HP_0033989		
HP:0008978	biolink:PhenotypicFeature	Necrotizing myopathy		UMLS:C4024608	hp.json		http://purl.obolibrary.org/obo/HP_0008978		
HP:0006316	biolink:PhenotypicFeature	Irregularly spaced teeth	Irregular distribution of the teeth along the dental arch, i.e., and irregular spatial pattern of teeth.	UMLS:C1845878	hp.json	Irregularly spaced teeth|Variability of spacing between teeth|Irregular dental spacing|Variability of dental spacing	http://purl.obolibrary.org/obo/HP_0006316		
HP:0033988	biolink:PhenotypicFeature	Amygdala microinfarct	An infarct located in the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe that can only be observed microscopically.		hp.json		http://purl.obolibrary.org/obo/HP_0033988		
HP:0031327	biolink:PhenotypicFeature	Transthyretin cardiac amyloidosis	A type of cardiac amyloidosis related to deposition of transthyretin (TTR), which is identified by immunohistochemical staining.		hp.json	TTR cardiac amyloidosis	http://purl.obolibrary.org/obo/HP_0031327		
HP:0008972	biolink:PhenotypicFeature	Decreased activity of mitochondrial respiratory chain	Decreased activity of the mitochondrial respiratory chain.	UMLS:C4024609|UMLS:C1835995|UMLS:C3276441	hp.json	Decreased activities of mitochondrial-encoded respiratory chain complexes|Decreased activity of mitochondrial respiratory complexes	http://purl.obolibrary.org/obo/HP_0008972		
HP:0006311	biolink:PhenotypicFeature	Generalized microdontia	A generalized form of microdontia.	UMLS:C4025065	hp.json	Decreased width of all teeth|Decreased size of all teeth|Tooth mass insufficiency|Hypotrophy of all teeth|Generalised microdontia|Decreased tooth mass	http://purl.obolibrary.org/obo/HP_0006311		
HP:0008970	biolink:PhenotypicFeature	Scapulohumeral muscular dystrophy		MSH:C562932|SNOMEDCT_US:240074006|UMLS:C0410192	hp.json		http://purl.obolibrary.org/obo/HP_0008970		
HP:0031331	biolink:PhenotypicFeature	Abnormal cardiomyocyte morphology	Any structural anomaly of cardiomyocytes, which are terminally differentiated muscle cells in the heart that are interconnected end to end by gap junctions, which allows coordinated contraction of heart tissue.		hp.json	Abnormal cardiac muscle cell morphology	http://purl.obolibrary.org/obo/HP_0031331		
HP:0033994	biolink:PhenotypicFeature	Dependency on parenteral nutrition	Inability to ingest sufficient quantities of nutrition by mouth or by tube-feeding with the corresponding requirement for intravenous administration of nutrition.		hp.json		http://purl.obolibrary.org/obo/HP_0033994		
HP:0031332	biolink:PhenotypicFeature	Cardiomyocyte degeneration	Deterioration of cardiomyocyte characterized by abnormal features such as loss of myofilaments, occurrence of cellular sequestration, decreased mitochondrial sizes and cellular debris.		hp.json		http://purl.obolibrary.org/obo/HP_0031332		
HP:0033993	biolink:PhenotypicFeature	Viral encephalitis	An inflammation of brain parenchyma due to infection with a virus. Viral encephalitis can occur as a rare complication of common infections (eg, herpes virus infections) or can occur as a characteristic presentation of rare viruses (eg, rabies virus infection). Encephalitis may be the only neurologic manifestation of infection, or may occur in association with meningitis, myelitis, radiculitis, or neuritis. Viral encephalitis is associated with neurological dysfunction.		hp.json		http://purl.obolibrary.org/obo/HP_0033993		
HP:0031333	biolink:PhenotypicFeature	Myocardial sarcomeric disarray	A disruption of the structure of the sarcomeres of cardiomyocytes. The sarcomere is the repeating unit between two Z lines comprised largely of myosin and actin that mediates contractility, and normally sarcomeres are aligned with the long axis of cells, with the Z bands being in register throughout the length of the cardiac myocytes.		hp.json	Myocardial sarcomere disarray	http://purl.obolibrary.org/obo/HP_0031333		
HP:0033996	biolink:PhenotypicFeature	Microvillar PAS-positive secretory granules	The presenceaccumulationof periodic acid-Schiff (PAS) granules in the subapical region of small intenstinal microvilli, appearing as different kinds of vesicular/tubular structures.		hp.json		http://purl.obolibrary.org/obo/HP_0033996		
HP:0033995	biolink:PhenotypicFeature	Microvillus inclusions	The presence of vacuoles bearing centripetal microvilli in small gut villus enterocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0033995		
HP:0031334	biolink:PhenotypicFeature	Cardiomyocyte inclusion bodies	Nuclear or cytoplasmic aggregates of stainable substances within cardiomyocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0031334		
HP:0033990	biolink:PhenotypicFeature	Cartilaginous tracheobronchomalacia	Softening of the tracheal and/or bronchial cartilage resulting in segmental tracheal and/or bronchial weakness.		hp.json	Cartilaginous malacia	http://purl.obolibrary.org/obo/HP_0033990		
GO:0009250	biolink:NamedThing	glucan biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0009250		
HP:0033992	biolink:PhenotypicFeature	Chronotropic incompetence	Inability of the heart to increase its rate commensurate with increased activity or demand.		hp.json		http://purl.obolibrary.org/obo/HP_0033992		
GO:0009251	biolink:NamedThing	glucan catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0009251		
HP:0031330	biolink:PhenotypicFeature	Perivascular myocardial immune cell infiltration	An increase in the number of immune cells in myocardial tissue concentrated in the spaces surrounding blood vessels.		hp.json		http://purl.obolibrary.org/obo/HP_0031330		
HP:0033991	biolink:PhenotypicFeature	Vasa previa	Vasa previa occurs when the membranes that contain the umbilical cord traverse the membranes overlying the internal os of the cervix. There is a high risk of fetal mortality if not identified perinatally.		hp.json		http://purl.obolibrary.org/obo/HP_0033991		
HP:0031339	biolink:PhenotypicFeature	Abnormal cadiomyocyte dystrophin staining	Anomalous staining of dystrophin in cardiomyocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0031339		
HP:0006329	biolink:PhenotypicFeature	Alveolar process hypoplasia	Underdevelopment of the alveolar process (also known as alveolar bone).	SNOMEDCT_US:708494003|UMLS:C1848905|UMLS:C3872671|UMLS:C4280453|UMLS:C4280452|UMLS:C4280451	hp.json	Underdevelopment of alveolar process of jaw|Hypoplastic alveolar bone|Deficiency of alveolar ridge|Underdevelopment of alveolar ridge|Hypotrophic alveolar process of jaw|Small alveolar ridge|Decreased size of alveolar process of jaw|Hypotrophic alveolar ridge|Deficiency of alveolar process of jaw|Hypoplasia of alveolar ridge|Decreased size of alveolar ridge|Small alveolar process of jaw	http://purl.obolibrary.org/obo/HP_0006329		
HP:0031335	biolink:PhenotypicFeature	Abnormal cardiomyocyte mitochondrial morphology	An anomaly of the structure of mitochondria within cardiomyocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0031335		
HP:0033998	biolink:PhenotypicFeature	Single-lobed right lung	A developmental defect of pulmonary lobation characterized by the presence of only one lobe of the right lung, which normally has three lobes.		hp.json		http://purl.obolibrary.org/obo/HP_0033998		
HP:0008986	biolink:PhenotypicFeature	Agenesis of the diaphragm	Congenital lack, i.e., aplasia of the diaphragm.	UMLS:C0221360|SNOMEDCT_US:702613006|SNOMEDCT_US:72424001	hp.json	Absent diaphragm|Agenesis of diaphragm	http://purl.obolibrary.org/obo/HP_0008986		
HP:0033997	biolink:PhenotypicFeature	Perinuclear cardiomyocyte vacuolization	Formation of vacuoles, i.e., membrane-bound organelles, in the portion of the cytoplasm near the nucleus within myocytes of the heart.		hp.json		http://purl.obolibrary.org/obo/HP_0033997		
HP:0031336	biolink:PhenotypicFeature	Intranuclear cardiomyocyte mitochondria	Abnormal localization of mitochondria within the nuclei of cardiomyocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0031336		
HP:0006326	biolink:PhenotypicFeature	Buried teeth encased in mucopolysaccharide		UMLS:C4025064	hp.json	Impacted teeth due to mucopolysaccharidoses|Failure of tooth eruption due to mucopolysaccharidoses|Failure of dental eruption due to mucopolysaccharidoses|Unerupted dentition due to mucopolysaccharidoses|Unerupted teeth due to mucopolysaccharidoses	http://purl.obolibrary.org/obo/HP_0006326		
HP:0031337	biolink:PhenotypicFeature	Abnormal cardiomyocyte connexin43 staining	Anomalous staining of Connexin43 in cardiomyocytes. Connexin43 (Cx43) is the primary gap junction protein in the working myocardium. Cx43 exhibits increased localization at the lateral membranes of cardiomyocytes in a variety of heart diseases.		hp.json		http://purl.obolibrary.org/obo/HP_0031337		
HP:0008988	biolink:PhenotypicFeature	Pelvic girdle muscle atrophy	Muscular atrophy affecting the muscles that attach to the pelvic girdle (the gluteal muscles, the lateral rotators, adductor magnus, adductor brevis, adductor longus, pectineus, and gracilis muscles).	UMLS:C0240679	hp.json	Pelvic girdle muscle wasting	http://purl.obolibrary.org/obo/HP_0008988		
HP:0033999	biolink:PhenotypicFeature	Bronchial hemorrhage	Bronchial hemorrhage is a focal bleeding located in the bronchial system. It can be diagnosed by tracheobronchoscopy.		hp.json	Bronchial bleeding	http://purl.obolibrary.org/obo/HP_0033999		
HP:0031338	biolink:PhenotypicFeature	Abnormal cardiomyocyte plakoglobin staining	Anomalous staining of plakoglobin in cardiomyocytes. Plakoglobin is a component of desmosomes in cardiomyocytes.		hp.json		http://purl.obolibrary.org/obo/HP_0031338		
HP:0006321	biolink:PhenotypicFeature	Multiple non-erupting secondary teeth		UMLS:C1848904	hp.json	Failure of eruption of multiple permanent teeth|Multiple non-erupting permanent teeth|Failure of eruption of multiple adult teeth|Multiple unerupted permanent teeth|Multiple non-erupting adult teeth|Multiple unerupted adult teeth	http://purl.obolibrary.org/obo/HP_0006321		
HP:0008985	biolink:PhenotypicFeature	Increased intramuscular fat	An abnormal increase in the amount of intramuscular fat tissue.	UMLS:C1835389	hp.json	Increased IM fat|Increased intramuscular fat	http://purl.obolibrary.org/obo/HP_0008985		
HP:0006323	biolink:PhenotypicFeature	Premature loss of primary teeth	Loss of the primary (also known as deciduous) teeth before the usual age.	UMLS:C0266052|SNOMEDCT_US:122483006|SNOMEDCT_US:39034005	hp.json	Premature loss of deciduous teeth|Premature exfoliation of deciduous teeth|Premature deciduous tooth loss|Early loss of primary teeth|Premature exfoliation of primary teeth|Premature loss of baby teeth|Early loss of baby teeth|Early loss of deciduous teeth	http://purl.obolibrary.org/obo/HP_0006323		hposlim_core
HP:0008984	biolink:PhenotypicFeature	Neck muscle hypoplasia	Underdevelopment of muscles of the neck.	UMLS:C4280409|UMLS:C4280408|UMLS:C1969000	hp.json	Hypotrophic neck muscle|Decreased size of neck muscle|Deficiency of neck muscle|Small neck muscle|Underdevelopment of neck muscle	http://purl.obolibrary.org/obo/HP_0008984		
HP:0008981	biolink:PhenotypicFeature	Calf muscle hypertrophy	Muscle hypertrophy affecting the calf muscles.	UMLS:C1843057	hp.json	Calf hypertrophy|Muscular hypertrophy of the calf muscles|Increased size of calf muscles	http://purl.obolibrary.org/obo/HP_0008981		
HP:0006380	biolink:PhenotypicFeature	Knee flexion contracture	A bent (flexed) knee joint that cannot be straightened actively or passively.	UMLS:C0409355|SNOMEDCT_US:202289003	hp.json	Flexion contractures at both knees|Knee flexion deformity|Knee flexion contractures|Contractures of the knees|Contractures of knees|Knee contractures|Knee contracture|Flexion contractures of knees|Inability to straighten knee|Flexion deformity of the knee|Flexion contracture of knees	http://purl.obolibrary.org/obo/HP_0006380		hposlim_core
HP:0006381	biolink:PhenotypicFeature	Rudimentary fibula	Absent or nearly absent fibula. (Does not include aplastic)	UMLS:C1844706	hp.json	Small to absent calf bone|Rudimentary to absent fibulae|Small to absent fibula	http://purl.obolibrary.org/obo/HP_0006381		
CHEBI:142533	biolink:ChemicalSubstance	->4)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-yl group	An organic group forming part of, and a proposed epitope within, globoside GM1.	PMID:7691279	hp.json	->4)-alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosylp-(1->4)-beta-D-glucopyranosyl|->4)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-yl|->4)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-yl group|->4)-alpha-D-galactosyl-(1->4)-beta-D-galactosylp-(1->4)-beta-D-glucosyl	http://purl.obolibrary.org/obo/CHEBI_142533		3_STAR
NBO:0002436	biolink:NamedThing	regulation of feeding behavior	"Any process that modulates the frequency, rate or extent of consumption of food or liquid" [NBOC:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0002436		
HP:0033925	biolink:PhenotypicFeature	Renal arteriole lymphocyte endoarterial hypercellularity	A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of increased number of lymphocytes in the arteriolar lumen.		hp.json	Endoarterial hypercellularity within arterioles consisting of lymphocytes	http://purl.obolibrary.org/obo/HP_0033925		
HP:0033924	biolink:PhenotypicFeature	Renal arteriole neutrophil endoarterial hypercellularity	A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of increased numbers of neutrophils within the arteriolar lumen.		hp.json	Endoarterial hypercellularity within arterioles consisting of neutrophils	http://purl.obolibrary.org/obo/HP_0033924		
HP:0033927	biolink:PhenotypicFeature	Arcuate artery endoarterial leukocyte hypercellularity	Arcuate artery endoarterial hypercellularity due to increased numbers of white blood cells (leukocytes).		hp.json	Endoarterial hypercellularity within arcuate artery consisting of leukocytes	http://purl.obolibrary.org/obo/HP_0033927		
HP:0033926	biolink:PhenotypicFeature	Renal arteriole intimal/medial multilamellation	Myointimal hyperplasia arranged in multiple concentric layers in the inner or middle layer of the arterioles of the kidney.		hp.json	Renal arteriole intimal/medial onion skinning|Renal arteriole intima/media multilamellation|Multilamellation (onion skinning) within renal arteriole intima/media	http://purl.obolibrary.org/obo/HP_0033926		
HP:0033921	biolink:PhenotypicFeature	Renal arteriole endoarterial hypercellularity	Abnormal and excessive number of cells (hypercellularity) in the lining (endothelium) of the arterioles of the kidney.		hp.json	Endoarterial hypercellularity within arterioles	http://purl.obolibrary.org/obo/HP_0033921		
HP:0006379	biolink:PhenotypicFeature	Proximal tibial hypoplasia		UMLS:C1856029	hp.json	Proximal tibial hypopolasia	http://purl.obolibrary.org/obo/HP_0006379		
HP:0033920	biolink:PhenotypicFeature	Renal arteriole intima/media storage material accumulation	Deposition of storage material other than amyloid (glycogen, glycosphingolipid in Fabry's disease, sphingomyelin in Nieman Pick disease, glucosylceramide in Gaucher's disease, gangliosides, mucopolysaccahrides, phytanic acid in Refsum disease) in the inner or middle layer of the arterioles of the kidney.		hp.json	Accumulated storage material within arteriolar intima/media	http://purl.obolibrary.org/obo/HP_0033920		
HP:0033923	biolink:PhenotypicFeature	Renal arteriole foam cell endoarterial hypercellularity	A type of renal arteriole leukocytic endoarterial hypercellularity due to the presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in arteriolar lumen.		hp.json	Endoarterial hypercellularity within arterioles consisting of foam cells	http://purl.obolibrary.org/obo/HP_0033923		
HP:0033922	biolink:PhenotypicFeature	Renal arteriole leukocytic endoarterial hypercellularity	A type of renal arteriole endoarterial hypercellularity due to increased number of white blood cells (leukocytes).		hp.json		http://purl.obolibrary.org/obo/HP_0033922		
HP:0006375	biolink:PhenotypicFeature	Dumbbell-shaped femur	The femur is shortened and displays flaring (widening) of the metaphyses.	UMLS:C4025052	hp.json	Dumbbell-shaped thighbone	http://purl.obolibrary.org/obo/HP_0006375		
HP:0006376	biolink:PhenotypicFeature	Limited elbow flexion		UMLS:C1856922	hp.json		http://purl.obolibrary.org/obo/HP_0006376		
UBERON:0002600	biolink:AnatomicalEntity	limbic lobe	Part of cerebral hemisphere located on the medial surface, forming a ring around the brain stem.	BAMS:LL|UMLS:C0458337|FMA:72719|BAMS:Limbic_lobe|BIRNLEX:1128|MESH:D065726|DHBA:12155|HBA:4219|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=834|CALOHA:TS-2061	hp.json	gyrus fornicatus|fornicate lobe|limbic lobe (carpenter)|fornicate gyrus|fornicate convolution|grande lobe limbique of Broca|lobus limbicus	http://purl.obolibrary.org/obo/UBERON_0002600		human_reference_atlas|uberon_slim|pheno_slim
HP:0006378	biolink:PhenotypicFeature	Osteolysis of patellae		UMLS:C4025051	hp.json		http://purl.obolibrary.org/obo/HP_0006378		
HP:0033929	biolink:PhenotypicFeature	Arcuate artery endoarterial neutrophil hypercellularity	A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of increased numbers of neutrophils withinin the lumen of arcuate artery.		hp.json	Endoarterial hypercellularity within arcuate artery consisting of neutrophils	http://purl.obolibrary.org/obo/HP_0033929		
HP:0006371	biolink:PhenotypicFeature	Broad long bone diaphyses	Increased width of the diaphysis of long bones.	UMLS:C4025053	hp.json	Broad shaft of long bone|Wide shaft of long bone	http://purl.obolibrary.org/obo/HP_0006371		
HP:0033928	biolink:PhenotypicFeature	Arcuate artery endoarterial foam cell hypercellularity	A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of lipid-filled cells, often a macrophage, with a vacuolated appearance in arteriolar lumen.		hp.json	Endoarterial hypercellularity within arcuate artery consisting of foam cells	http://purl.obolibrary.org/obo/HP_0033928		
HP:0006390	biolink:PhenotypicFeature	Anterior tibial bowing	An abnormal anterior bending or curvature of the tibia.	UMLS:C1861937	hp.json	Anterior bowing of tibia	http://purl.obolibrary.org/obo/HP_0006390		
HP:0006391	biolink:PhenotypicFeature	Overtubulated long bones	Overconstriction, or narrowness of the diaphysis and metaphysis of long bones.	UMLS:C1848769	hp.json		http://purl.obolibrary.org/obo/HP_0006391		
HP:0006392	biolink:PhenotypicFeature	Increased density of long bones	An abnormal increase in the bone density of the long bones.	UMLS:C1849307	hp.json	Increased density of long bones	http://purl.obolibrary.org/obo/HP_0006392		
HP:0033930	biolink:PhenotypicFeature	Arcuate artery endoarterial lymphocyte hypercellularity	A type of arcuate artery endoarterial leukocyte hypercellularity due to the presence of increased number of lymphocytes in the lumen of arcuate artery.		hp.json	Endoarterial hypercellularity within arcuate artery consisting of lymphocytes	http://purl.obolibrary.org/obo/HP_0033930		
HP:0033936	biolink:PhenotypicFeature	Cortical radial artery intima/media liquefactive necrosis	A type of cortical radial artery intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.		hp.json	Liquefactive necrosis within interlobular arterial intima/media	http://purl.obolibrary.org/obo/HP_0033936		
HP:0033935	biolink:PhenotypicFeature	Cortical radial artery intima/media necrosis	Cell death (necrosis) in the inner or middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney.		hp.json	Necrosis within interlobular arterial intima/media	http://purl.obolibrary.org/obo/HP_0033935		
HP:0033938	biolink:PhenotypicFeature	Renal arteriole intima/media necrosis	Cell death (necrosis) in the inner or middle layer of the arterioles of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033938		
HP:0033937	biolink:PhenotypicFeature	Cortical radial artery intima/media coagulative necrosis	A type of cortical radial artery intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures.		hp.json		http://purl.obolibrary.org/obo/HP_0033937		
HP:0033932	biolink:PhenotypicFeature	Arcuate artery intima/media coagulative necrosis	A type of arcuate artery intima/media necrosis in which the necrotic tissue retains the outlines of the dead (necrotic) structures.		hp.json	Coagulative necrosis within interlobular arterial intima/media	http://purl.obolibrary.org/obo/HP_0033932		
HP:0033931	biolink:PhenotypicFeature	Arcuate artery intima/media necrosis	Death of tissue in the inner or middle layer of the arcuate artery of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033931		
HP:0033934	biolink:PhenotypicFeature	Arcuate vein intimal/medial storage material accumulation	Accumulation of material other than amyloid (glycogen, glycosphingolipid in Fabry's disease, sphingomyelin in Nieman Pick disease, glucosylceramide in Gaucher's disease, gangliosides, mucopolysaccahrides, phytanic acid in Refsum disease) in the inner or middle layer of the arcuate veins of the kidney.		hp.json	Multilamellation (onion skinning) within arteriolar intima/media|Renal arteriole intima/media onion skinning	http://purl.obolibrary.org/obo/HP_0033934		
HP:0033933	biolink:PhenotypicFeature	Arcuate artery intima/media liquefactive necrosis	A type of arcuate artery intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.		hp.json	Liquefactive necrosis of the arcuate artery intima/media	http://purl.obolibrary.org/obo/HP_0033933		
HP:0006386	biolink:PhenotypicFeature	Hypoplastic distal radial epiphyses	Underdevelopment of the distal epiphysis of the radius.	UMLS:C1969286	hp.json		http://purl.obolibrary.org/obo/HP_0006386		
HP:0006387	biolink:PhenotypicFeature	Wide distal femoral metaphysis	Increased width of the distal part of the shaft (metaphysis) of the femur.	UMLS:C1849309	hp.json	Broad outermost wide portion of thighbone|Wide distal metaphysis of femur	http://purl.obolibrary.org/obo/HP_0006387		
HP:0006389	biolink:PhenotypicFeature	Limited knee flexion	Reduced ability to flex (bend) the knee joint.	UMLS:C1839512	hp.json		http://purl.obolibrary.org/obo/HP_0006389		
HP:0033939	biolink:PhenotypicFeature	Renal arteriole intima/media liquefactive necrosis	A type of renal arteriole intima/media necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.		hp.json	Liquefactive necrosis of the renal arteriolar intima/media	http://purl.obolibrary.org/obo/HP_0033939		
HP:0006383	biolink:PhenotypicFeature	Progressive bowing of long bones	Progressive bending or abnormal curvature of a long bone.	UMLS:C1857137	hp.json		http://purl.obolibrary.org/obo/HP_0006383		
HP:0006384	biolink:PhenotypicFeature	Club-shaped distal femur	An abnormal conformation of the femur that becomes gradually enlarged towards the distal end. This feature affects the distal femoral metaphysis and epiphysis.	UMLS:C1857505	hp.json	Club-shaped distal femora|Club-shaped outermost end of thighbone	http://purl.obolibrary.org/obo/HP_0006384		
HP:0006385	biolink:PhenotypicFeature	Short lower limbs	Shortening of the legs related to developmental hypoplasia of the bones of the leg.	UMLS:C0426901|SNOMEDCT_US:249786007	hp.json	Short legs|Short lower limbs	http://purl.obolibrary.org/obo/HP_0006385		hposlim_core
OBO:MAXO_0001010	biolink:NamedThing	leukocyte count	A test to determine the number of leukocytes in a sample of blood.	NCIT:C51948	hp.json	WBC|white blood cell count	http://purl.obolibrary.org/obo/MAXO_0001010		
HP:0033941	biolink:PhenotypicFeature	Granulomatous arteriolitis of the arteriolar intima/media	A type of renal intimal/medial arteriolitis characteriezed by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries.		hp.json	Granulomatous arteriolitis within arteriolar intima/media	http://purl.obolibrary.org/obo/HP_0033941		
HP:0033940	biolink:PhenotypicFeature	Renal arteriole intima/media coagulative necrosis	A type of renal arteriole intima/media necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures.		hp.json		http://purl.obolibrary.org/obo/HP_0033940		
HP:0033947	biolink:PhenotypicFeature	Renal arteriole intima/media crystal accumulation	Deposition of crystals such as uric acid, oxalate, or cystine in the inner or middle layer of the arterioles of the kidney.		hp.json	Accumulated crystals within renal arteriolar intima/media	http://purl.obolibrary.org/obo/HP_0033947		
HP:0033946	biolink:PhenotypicFeature	Arcuate vein intima/media crystal accumulation	Deposition of crystals such as uric acid, oxalate, or cystine in the inner or middle layer of the arcuate veins of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033946		
HP:0033949	biolink:PhenotypicFeature	Arcuate artery intima/media granulomatous arteriitis	A type of arcuate artery intima/media granulomatous arteriitis characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed arteries.		hp.json	Granulomatous arteritis within arcuate arterial intima/media	http://purl.obolibrary.org/obo/HP_0033949		
HP:0033948	biolink:PhenotypicFeature	Arcuate artery intima/media arteriitis	Inflammation of the inner or middle layer of the arcuate arteries of the kidney.		hp.json	Arteritis within arcuate arterial intima/media	http://purl.obolibrary.org/obo/HP_0033948		
HP:0033943	biolink:PhenotypicFeature	Arcuate vein medial/intimal coagulative necrosis	A type of arcuate vein medial/intimal necrosis in which the dead (necrotic) tissue retains the outlines of the dead structures.		hp.json	Coagulative necrosis within arcuate vein intima/media	http://purl.obolibrary.org/obo/HP_0033943		
HP:0006357	biolink:PhenotypicFeature	Premature loss of permanent teeth	Premature loss of the permanent teeth.	UMLS:C1969738	hp.json	Early loss of permanent teeth|Early loss of adult teeth|Early loss of secondary dentition|Premature loss of secondary teeth|Premature loss of adult teeth	http://purl.obolibrary.org/obo/HP_0006357		
HP:0033942	biolink:PhenotypicFeature	Arcuate vein medial/intimal necrosis	Cell death (necrosis) of the inner or middle layer of the arcuate veins of the kidney.		hp.json	Necrosis within arcuate vein intima/media	http://purl.obolibrary.org/obo/HP_0033942		
HP:0006358	biolink:PhenotypicFeature	Shovel-shaped maxillary central incisors	A tooth with a crown with marked lingual or palatal marginal ridges causing scooped lingual or palatal surfaces.	UMLS:C1833168	hp.json	Shovel-shaped upper front teeth|Shovel tooth	http://purl.obolibrary.org/obo/HP_0006358		
HP:0033945	biolink:PhenotypicFeature	Arcuate intimal/medial granulomatous venulitis	A type of arcuate intimal/medial venulitis characterized by circumscribed inflammatory lesions comprised primarily of macrophages present in inflamed veins.		hp.json		http://purl.obolibrary.org/obo/HP_0033945		
HP:0033944	biolink:PhenotypicFeature	Arcuate vein medial/intimal liquefactive necrosis	A type of arcuate vein medial/intimal necrosis in which the dead (necrotic) tissue breaks down such that cellular detail is no longer recognized.		hp.json	Liquefactive necrosis within arcuate vein intima/media	http://purl.obolibrary.org/obo/HP_0033944		
HP:0006353	biolink:PhenotypicFeature	Hypoplasia of the tooth germ	Developmental hypoplasia of the tooth germ, i.e., of the structure that forms in odontogenesis that will develop into a tooth.	UMLS:C4025055	hp.json	Hypoplastic tooth buds|Small tooth germ|Decreased size of tooth germ|Underdevelopment of tooth germ|Decreased size of tooth bud|Underdevelopment of tooth bud|Hypotrophic tooth germ|Small tooth bud	http://purl.obolibrary.org/obo/HP_0006353		
HP:0006355	biolink:PhenotypicFeature	Agenesis of mandibular central incisor	Agenesis of lower secondary incisor or lower primary incisor.	UMLS:C1840225|UMLS:C4025054	hp.json	Absence of mandibular central incisor|Failure of development of mandibular central incisor|Absence of lower central incisor|Missing mandibular central incisor|Missing lower central incisor	http://purl.obolibrary.org/obo/HP_0006355		
HP:0006350	biolink:PhenotypicFeature	Pulp obliteration	Mineralized substance filling the entire dental pulp space.	UMLS:C4020817|UMLS:C4025057|UMLS:C4280448	hp.json	Obliteration of the pulp chamber|Pulp canal obliteration|Small pulp chamber of tooth|Narrowing of pulp chamber of tooth|Crescent/chevron-shaped pulp chambers|Reduced size of pulp chamber of tooth	http://purl.obolibrary.org/obo/HP_0006350		
HP:0006352	biolink:PhenotypicFeature	Failure of eruption of permanent teeth	Lack of tooth eruption of the secondary dentition.	UMLS:C4025056|UMLS:C4280447	hp.json	Unerupted permanent teeth|Unerupted permanent dentition|Failure of eruption of adult teeth|Unerupted adult teeth|Unerupted adult dentition	http://purl.obolibrary.org/obo/HP_0006352		
OBO:MAXO_0001000	biolink:NamedThing	functional magnetic resonance imaging procedure	The principle of functional MRI imaging is to take a series of images of an organ in quick succession and to statistically analyze the images for differences among them.  Most commonly used in studies of brain function.	NCIT:C17958	hp.json	fMRI|Functional MRI	http://purl.obolibrary.org/obo/MAXO_0001000		
HP:0006370	biolink:PhenotypicFeature	Distal ulnar epiphyseal stippling	The presence of abnormal punctate (speckled, dot-like) calcifications in the distal epiphysis of the ulna.	UMLS:C4021600	hp.json	Distal ulnar epiphyseal calcifications	http://purl.obolibrary.org/obo/HP_0006370		
HP:0033950	biolink:PhenotypicFeature	Cortical radial artery intraluminal thrombi	Mixture of fibrin, red blood cells, platelets partly or completely occluding vascular lumen within the interior space of cortical radial arteries (interlobular arteries) of the kidney.		hp.json	Intraluminal thrombi within interlobular arterial lumen	http://purl.obolibrary.org/obo/HP_0033950		
HP:0033952	biolink:PhenotypicFeature	Abnormal cortical radial artery endothelium morphology	Abnormal structural characteristics of the lining (endothelium) of the cortical radial arteries (also known as interlobular arteries) of the kidney.		hp.json	Abnormalities of the interlobular arterial endothelium	http://purl.obolibrary.org/obo/HP_0033952		
HP:0033951	biolink:PhenotypicFeature	Cortical radial artery intraluminal organized thrombi	Thrombi containing fibrous tissue and capillary-like vascular channels within the interior space of cortical radial arteries (interlobular arteries) of the kidney.		hp.json	Organized thrombi within interlobular arterial lumen	http://purl.obolibrary.org/obo/HP_0033951		
HP:0033958	biolink:PhenotypicFeature	Cortical radial artery foam cell hypercellularity	A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of lipid-filled cells, often macrophages, with a vacuolated appearance in the lumen of cortical radial artery (also known as the interlobular artery) of the kidney.		hp.json	Endocapillary hypercellularity within interlobular arterial endothelium consisting of foam cells	http://purl.obolibrary.org/obo/HP_0033958		
HP:0033957	biolink:PhenotypicFeature	Cortical radial artery neutrophil hypercellularity	A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of increased numbers of neutrophils in the lumen of cortical radial arteries.		hp.json	Endocapillary hypercellularity within interlobular arterial endothelium consisting of neutrophils	http://purl.obolibrary.org/obo/HP_0033957		
HP:0033959	biolink:PhenotypicFeature	Cortical radial artery intima/media arteriosclerosis	Thickening of the intima of the cortical radial artery (also known as the interlobular artery) of the kidney characterized by fibrosis and/or duplication of the elastic lamina.		hp.json	Arteriosclerosis within interlobular arterial intima/media	http://purl.obolibrary.org/obo/HP_0033959		
HP:0006368	biolink:PhenotypicFeature	Forearm reduction defects		UMLS:C1849327	hp.json		http://purl.obolibrary.org/obo/HP_0006368		
HP:0033954	biolink:PhenotypicFeature	Cortical radial artery hypercellularity	Proliferation of endothelial cells (increased number of cells) of the lining (endothelium) of the cortical radial arteries (also known as interlobular arteries) of the kidney.		hp.json	Endoarterial hypercellularity within interlobular artery	http://purl.obolibrary.org/obo/HP_0033954		
HP:0033953	biolink:PhenotypicFeature	Cortical radial artery endotheliosis	Enlargement of endothelial cells of the cortical radial arteries (also known as the interlobular arteries) of the kidney because of cytoplasmic swelling.		hp.json	Endotheliosis within interlobular arteries	http://purl.obolibrary.org/obo/HP_0033953		
HP:0006369	biolink:PhenotypicFeature	Irregular patellae	An alteration of the normally relatively smooth margins of the kneecap in radiographic images leading to an irregular contour.	UMLS:C1836870	hp.json	Irregular patellar margins|Irregular patellar contour	http://purl.obolibrary.org/obo/HP_0006369		
HP:0033956	biolink:PhenotypicFeature	Cortical radial artery lymphocyte hypercellularity	A type of cortical radial artery endoarterial leukocyte hypercellularity due to the presence of increased number of lymphocytes in the lumen of cortical radial arteries.		hp.json	Endoarterial hypercellularity within interlobular artery consisting of lymphocytes	http://purl.obolibrary.org/obo/HP_0033956		
HP:0033955	biolink:PhenotypicFeature	Cortical radial artery leukocyte hypercellularity	A type of cortical radial artery endoarterial hypercellularity due to increased numbers of white blood cells (leukocytes).		hp.json	Endoarterial hypercellularity within interlobular artery consisting of leukocytes	http://purl.obolibrary.org/obo/HP_0033955		
GO:0009205	biolink:BiologicalProcess	purine ribonucleoside triphosphate metabolic process	The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.		hp.json	purine ribonucleoside triphosphate metabolism	http://purl.obolibrary.org/obo/GO_0009205		
OBO:MAXO_0001008	biolink:NamedThing	platelet count	The determination of the number of platelets in a blood sample, usually expressed as platelets per cubic millimeter (cmm) of whole blood.	NCIT:C51951	hp.json	thrombocyte count	http://purl.obolibrary.org/obo/MAXO_0001008		
OBO:MAXO_0001007	biolink:NamedThing	erythrocyte count	The determination of the number of erythrocytes in a blood sample.	NCIT:C51946	hp.json	red cell count|RBC|red blood cell count	http://purl.obolibrary.org/obo/MAXO_0001007		
HP:0006366	biolink:PhenotypicFeature	Adductor longus contractures		UMLS:C1859524	hp.json		http://purl.obolibrary.org/obo/HP_0006366		
OBO:MAXO_0001006	biolink:NamedThing	blood cell count	The determination of the number of red blood cells, white blood cells, and platelets in a blood sample.	NCIT:C28133	hp.json	CBC|full blood count|complete blood count	http://purl.obolibrary.org/obo/MAXO_0001006		
HP:0006367	biolink:PhenotypicFeature	Crumpled long bones	An crumpled radiographic appearance of the long bones, as if the long bone had been crushed together producing irregularities. This feature is the result of multiple fractures and repeated rounds of ineffective healing, as can be seen for instance in severe forms of osteogenesis imperfecta.	UMLS:C1970497	hp.json	Crumpled long bones	http://purl.obolibrary.org/obo/HP_0006367		
HP:0006361	biolink:PhenotypicFeature	Irregular femoral epiphysis		UMLS:C1850658	hp.json	Irregular thighbone end part	http://purl.obolibrary.org/obo/HP_0006361		
HP:0006362	biolink:PhenotypicFeature	Varus deformity of humeral neck		UMLS:C1854948	hp.json		http://purl.obolibrary.org/obo/HP_0006362		
OBO:MAXO_0001009	biolink:NamedThing	neutrophil count	A test to determine the number of neutrophils in a sample of blood.		hp.json		http://purl.obolibrary.org/obo/MAXO_0001009		
UBERON:2002260	biolink:AnatomicalEntity	premaxillary-maxillary joint	Joint that articulates the premaxilla and maxilla. Premaxillary-maxillary joint is paired.		hp.json		http://purl.obolibrary.org/obo/UBERON_2002260		
HP:0008915	biolink:PhenotypicFeature	Childhood-onset truncal obesity	Truncal obesity with onset during childhood, defined as between 2 and 10 years of age.	UMLS:C1859846	hp.json	Truncal obesity apparent in childhood	http://purl.obolibrary.org/obo/HP_0008915		
HP:0008929	biolink:PhenotypicFeature	Asymmetric short stature		UMLS:C4024614	hp.json		http://purl.obolibrary.org/obo/HP_0008929		
GO:0061792	biolink:BiologicalProcess	secretory granule maturation	Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodelling.		hp.json		http://purl.obolibrary.org/obo/GO_0061792		
HP:0008921	biolink:PhenotypicFeature	Neonatal short-limb short stature	A type of short-limbed dwarfism that is manifest beginning in the neonatal period.	UMLS:C1850171	hp.json	Short limb dwarfism recognisable at birth|Short limb dwarfism recognizable at birth|Neonatal short-limbed dwarfism|Short-limbed dwarfism identifiable at birth|Short-limb dwarfism identifiable at birth|Short-limb dwarfism identifiable neonatally|Dwarfism, neonatal short-limbed	http://purl.obolibrary.org/obo/HP_0008921		
HP:0008922	biolink:PhenotypicFeature	Childhood-onset short-trunk short stature	A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with onset in childhood.	UMLS:C3148833	hp.json	Disproportionate short-trunk short stature, identifiable in childhood|Short-trunk dwarfism identifiable during childhood|Childhood-onset short-trunk short stature	http://purl.obolibrary.org/obo/HP_0008922		
GO:0046185	biolink:BiologicalProcess	aldehyde catabolic process	The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.		hp.json	aldehyde degradation|aldehyde catabolism|aldehyde breakdown	http://purl.obolibrary.org/obo/GO_0046185		
GO:0046189	biolink:BiologicalProcess	phenol-containing compound biosynthetic process	The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.		hp.json	phenol-containing compound anabolism|phenol-containing compound synthesis|phenol-containing compound formation|phenol-containing compound biosynthesis	http://purl.obolibrary.org/obo/GO_0046189		
HP:0033903	biolink:PhenotypicFeature	Arcuate artery endoarterial hypercellularity	Proliferation of endothelial cells (increased number of cells) of the lining (endothelium) of the arcuate arteries of the kidney.		hp.json	Endoarterial hypercellularity within arcuate artery	http://purl.obolibrary.org/obo/HP_0033903		
HP:0033902	biolink:PhenotypicFeature	Arcuate artery endotheliosis	Enlargement of endothelial cells of the arcuate arteries of the kidney because of cytoplasmic swelling.		hp.json	Endotheliosis within arcuate arteries	http://purl.obolibrary.org/obo/HP_0033902		
GO:0009199	biolink:BiologicalProcess	ribonucleoside triphosphate metabolic process	The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.		hp.json	ribonucleoside triphosphate metabolism	http://purl.obolibrary.org/obo/GO_0009199		
HP:0033905	biolink:PhenotypicFeature	Arcuate artery intima/media arteriosclerosis	Thickening of the intima of the arcuate arteries of the kidney with fibrosis and/or duplication of the elastic lamina.		hp.json	Arteriosclerosis within arcuate arterial intima/media	http://purl.obolibrary.org/obo/HP_0033905		
HP:0033904	biolink:PhenotypicFeature	Renal arteriole intima/media hyalinosis	Accumulation of amorphous, eosinophilic, glassy, periodic acid-Schiff (PAS)-positive, silver-negative material (hyalinosis) in the inner or middle layer of the renal arterioles. This feature may be accompanied by hypertrophy of the media and intima fibrosis.		hp.json		http://purl.obolibrary.org/obo/HP_0033904		
HP:0033901	biolink:PhenotypicFeature	Abnormal arcuate artery endothelium morphology	Any structural anomaly of the lining (endothelium) of the arcuate arteries of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033901		
HP:0033900	biolink:PhenotypicFeature	Renal arteriole intima/media amyloidosis	Amorphous extracellular substance in the inner or middle layer of renal arterioles. Amyloidosis stains Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy.		hp.json	Amyloidosis within renal arteriolar intima/media	http://purl.obolibrary.org/obo/HP_0033900		
HP:0033907	biolink:PhenotypicFeature	Renal arteriole intima/media arteriolosclerosis	Thickening of the intima of renal arterioles with fibrosis and/or duplication of the elastic lamina.		hp.json		http://purl.obolibrary.org/obo/HP_0033907		
HP:0033906	biolink:PhenotypicFeature	Renal intimal/medial arteriolitis	Inflammation of an arteriole of the kidney, which may involve only the intma or can be transmural.		hp.json		http://purl.obolibrary.org/obo/HP_0033906		
GO:0097734	biolink:BiologicalProcess	extracellular exosome biogenesis	The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.		hp.json	exosome production|exosome assembly or secretion|intraluminal vesicle assembly|exosome biogenesis|ILV assembly	http://purl.obolibrary.org/obo/GO_0097734		
HP:0033909	biolink:PhenotypicFeature	Arcuate vein medial hypertrophy	Increased thickness of middle layer of the arcuate veins of the kidney.		hp.json	Medial hypertrophy within arcuate veins	http://purl.obolibrary.org/obo/HP_0033909		
HP:0033908	biolink:PhenotypicFeature	Renal arteriole medial atrophy	Atrophy (wasting, decreased thickness) of of the middle layer of the arterioles of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033908		
HP:0008909	biolink:PhenotypicFeature	Lethal short-limbed short stature		UMLS:C2674171	hp.json	Lethal short-limbed dwarfism|Lethal micromelic dwarfism	http://purl.obolibrary.org/obo/HP_0008909		
HP:0033914	biolink:PhenotypicFeature	Arcuate artery intima/media amyloidosis	Amorphous extracellular substance in the inner or middle layer of the arcuate arteries of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy.		hp.json	Amyloidosis within arcuate arterial intima/media	http://purl.obolibrary.org/obo/HP_0033914		
HP:0033913	biolink:PhenotypicFeature	Cortical radial artery medial/intimal arteriitis	Inflammation of a the intima or the entire wall of cortical radial arteries (also known as the interlobular arteries) of the kidney.		hp.json	Interlobular artery medial/intimal arteriitis|Arteritis within interlobular arterial intima/media	http://purl.obolibrary.org/obo/HP_0033913		
HP:0008905	biolink:PhenotypicFeature	Rhizomelia	Disproportionate shortening of the proximal segment of limbs (i.e. the femur and humerus).	UMLS:C1866730	hp.json	Short stature, rhizomelic|Rhizomelic shortening|Rhizomelic short stature|Disproportionately short upper portion of limb|Rhizomelic short limbs|Rhizomelic limb shortening|Symmetrical rhizomelic limb shortening|Rhizomelic dwarfism	http://purl.obolibrary.org/obo/HP_0008905		hposlim_core
HP:0033916	biolink:PhenotypicFeature	Medial/intimal arcuate venosclerosis	Thickening of the intima with fibrosis and/or duplication of the elastic lamina in arcuate veins.		hp.json		http://purl.obolibrary.org/obo/HP_0033916		
HP:0033915	biolink:PhenotypicFeature	Arcuate artery intimal mucoid edema	Accumulation of edematous extracellular matrix in intima resembling mucus. This feature appears pale blue on hematoxylin and eosin staining.		hp.json		http://purl.obolibrary.org/obo/HP_0033915		
HP:0033910	biolink:PhenotypicFeature	Arcuate vein medial atrophy	Atrophy (wasting, decreased thickness) of the middle layer of the arcuate veins of the kidney.		hp.json	Medial atrophy within arcuate veins	http://purl.obolibrary.org/obo/HP_0033910		
HP:0033912	biolink:PhenotypicFeature	Cortical radial artery medial atrophy	Atrophy (wasting, decreased thickness) of the middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney.		hp.json	Interlobular artery medial atrophy|Medial atrophy within interlobular arteries	http://purl.obolibrary.org/obo/HP_0033912		
HP:0033911	biolink:PhenotypicFeature	Cortical radial artery medial hypertrophy	Increased thickness of the middle layer of the cortical radial arteries (also known as the interlobular arteries) of the kidney.		hp.json	Interlobular artery medial hypertrophy|Medial hypertrophy within interlobular arteries	http://purl.obolibrary.org/obo/HP_0033911		
HP:0033918	biolink:PhenotypicFeature	Renal arteriole medial hypertrophy	Increased thickness of middle layer of the arterioles of the kidney.		hp.json	Medial hypertrophy within arterioles	http://purl.obolibrary.org/obo/HP_0033918		
HP:0033917	biolink:PhenotypicFeature	Arcuate intimal/medial venulitis	Inflammation of arcuate veins of the kidney, which may involve only the intima or can be transmural.		hp.json	Venulitis within arcuate vein intima/media	http://purl.obolibrary.org/obo/HP_0033917		
HP:0033919	biolink:PhenotypicFeature	Medial/intimal arcuate venulitis	Inflammation of the inner or middle layer of arcuate venules. This feature may involve only the intima or it can be transmural.		hp.json		http://purl.obolibrary.org/obo/HP_0033919		
GO:0009185	biolink:BiologicalProcess	ribonucleoside diphosphate metabolic process	The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.		hp.json	ribonucleoside diphosphate metabolism	http://purl.obolibrary.org/obo/GO_0009185		
HP:0008959	biolink:PhenotypicFeature	Distal upper limb muscle weakness	Reduced strength of the distal musculature of the arms.	UMLS:C3150620	hp.json		http://purl.obolibrary.org/obo/HP_0008959		
GO:0009179	biolink:BiologicalProcess	purine ribonucleoside diphosphate metabolic process	The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.		hp.json	purine ribonucleoside diphosphate metabolism	http://purl.obolibrary.org/obo/GO_0009179		
HP:0008954	biolink:PhenotypicFeature	Intrinsic hand muscle atrophy	Atrophy of the intrinsic muscle groups of the hand, comprising the thenar and hypothenar muscles; the interossei muscles; and the lumbrical muscles.	UMLS:C1864716	hp.json		http://purl.obolibrary.org/obo/HP_0008954		
HP:0008953	biolink:PhenotypicFeature	Pectoralis major hypoplasia	Underdevelopment of the pectoralis major.	UMLS:C1840086	hp.json	Pectoralis major muscle hypoplasia	http://purl.obolibrary.org/obo/HP_0008953		
HP:0008956	biolink:PhenotypicFeature	Proximal lower limb amyotrophy	Muscular atrophy affecting proximally located muscles of the legs, i.e., of the thigh.	UMLS:C1836767	hp.json	Thigh muscle atrophy|Proximal lower limb muscle atrophy|Wasting of thigh muscle|Amyotrophy involving the thigh|Amyotrophy of the thigh musculature	http://purl.obolibrary.org/obo/HP_0008956		
HP:0008955	biolink:PhenotypicFeature	Progressive distal muscular atrophy	Progressive muscular atrophy affecting muscles in the distal portions of the extremities.	UMLS:C4024613	hp.json		http://purl.obolibrary.org/obo/HP_0008955		
HP:0008952	biolink:PhenotypicFeature	Shoulder muscle hypoplasia	Underdevelopment of muscles of the shoulder.	UMLS:C1969001	hp.json	Underdeveloped shoulder muscle	http://purl.obolibrary.org/obo/HP_0008952		
GO:0071169	biolink:BiologicalProcess	establishment of protein localization to chromatin	The directed movement of a protein to a part of a chromosome that is organized into chromatin.		hp.json	establishment of protein localisation to chromatin	http://purl.obolibrary.org/obo/GO_0071169		
GO:0071168	biolink:BiologicalProcess	protein localization to chromatin	Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin.		hp.json	protein localisation to chromatin	http://purl.obolibrary.org/obo/GO_0071168		
GO:0010160	biolink:BiologicalProcess	formation of animal organ boundary	The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues.		hp.json	organ boundary specification	http://purl.obolibrary.org/obo/GO_0010160		
HP:0008969	biolink:PhenotypicFeature	Leg muscle stiffness		UMLS:C4024610	hp.json		http://purl.obolibrary.org/obo/HP_0008969		
HP:0008968	biolink:PhenotypicFeature	Muscle hypertrophy of the lower extremities	Muscle hypertrophy primarily affecting the legs.	UMLS:C1850663	hp.json		http://purl.obolibrary.org/obo/HP_0008968		
HP:0006308	biolink:PhenotypicFeature	Atrophy of alveolar ridges		UMLS:C4280455|UMLS:C1855642|UMLS:C4280454	hp.json	Alveolar bone loss|Resorption of alveolar processes of jaw|Atrophy of alveolar processes of jaw|Atrophy of alveolar margins|Resorption of alveolar margins|Flattening of alveolar processes of jaw|Resorption of alveolar ridges|Flattening of alveolar ridges|Shrinking of alveolar ridges|Flattening of alveolar margin|Flattening of gum ridges|Shrinking of gum ridges	http://purl.obolibrary.org/obo/HP_0006308		
HP:0006302	biolink:PhenotypicFeature	Dagger-shaped pulp calcifications	Dagger-shaped calcifications in the dental pulp.	UMLS:C4025067	hp.json	Dagger shaped pulp stones|Dagger shaped pulp denticles	http://purl.obolibrary.org/obo/HP_0006302		
HP:0008964	biolink:PhenotypicFeature	Nonprogressive muscular atrophy	Muscular atrophy that does not display a progression in severity with time.	UMLS:C4024611	hp.json		http://purl.obolibrary.org/obo/HP_0008964		
HP:0008967	biolink:PhenotypicFeature	Exercise-induced muscle stiffness	A type of muscle stiffness that occurs following physical exertion.	UMLS:C1855579	hp.json	Exercise-induced muscle stiffness|Muscle stiffness with exercise|Muscle stiffness, exercise-induced	http://purl.obolibrary.org/obo/HP_0008967		
HP:0006304	biolink:PhenotypicFeature	Widely-spaced incisors		SNOMEDCT_US:196409003|UMLS:C0399545	hp.json	Widely spaced front teeth|Gap between front teeth|Anterior diastema of teeth|Diastema between front teeth|Diastema between incisors	http://purl.obolibrary.org/obo/HP_0006304		
HP:0008963	biolink:PhenotypicFeature	Tibialis muscle weakness	Muscle weakness affecting the tibialis anterior muscle.	UMLS:C4024612	hp.json		http://purl.obolibrary.org/obo/HP_0008963		
HP:0008962	biolink:PhenotypicFeature	Calf muscle hypoplasia	Underdevelopment of the muscuklature of the calf.	UMLS:C3805450	hp.json	Hypoplastic calf muscles|Underdeveloped calf muscles	http://purl.obolibrary.org/obo/HP_0008962		
GO:0010171	biolink:BiologicalProcess	body morphogenesis	The process in which the anatomical structures of the soma are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0010171		
UBERON:0036073	biolink:AnatomicalEntity	respiratory primordium mesenchyme		EHDAA2:0004071	hp.json	respiratory primordium associated mesenchyme	http://purl.obolibrary.org/obo/UBERON_0036073		
CHEBI:142590	biolink:ChemicalSubstance	3-aminoisobutanoic acid zwitterion	Zwitterionic form of 3-aminoisobutyric acid arising from migration of a proton from the carboxy group to the amino group; major species at pH 7.3.		hp.json	3-aminoisobutanoate|3-ammonio-2-methylpropanoate|3-azaniumyl-2-methylpropanoate	http://purl.obolibrary.org/obo/CHEBI_142590		3_STAR
UBERON:0036072	biolink:AnatomicalEntity	respiratory primordium epithelium		EHDAA2:0004070	hp.json		http://purl.obolibrary.org/obo/UBERON_0036072		
UBERON:0036074	biolink:AnatomicalEntity	vein of vestibular aqueduct	A vein that leaves the vestibule through an individual bone canal running parallel to the vestibular aqueduct up to the dura of the posterior side of the petrosa in the area of the endolymphatic sac. It then opens in the inferior petrosal sinus or the jugular bulb. The vein receives other branches from the bone, dura and sac.	FMA:52367	hp.json	vena aqueductus vestibuli|vestibular aqueduct vein	http://purl.obolibrary.org/obo/UBERON_0036074		human_reference_atlas
GO:0034110	biolink:BiologicalProcess	regulation of homotypic cell-cell adhesion	Any process that modulates the frequency, rate, or extent of homotypic cell-cell adhesion.		hp.json		http://purl.obolibrary.org/obo/GO_0034110		
HP:0008936	biolink:PhenotypicFeature	Axial hypotonia	Muscular hypotonia (abnormally low muscle tone) affecting the musculature of the trunk.	UMLS:C1853743	hp.json	Truncal hypotonia|Muscular hypotonia of the trunk|Low muscle tone in trunk	http://purl.obolibrary.org/obo/HP_0008936		
HP:0008935	biolink:PhenotypicFeature	Generalized neonatal hypotonia	Muscular hypotonia (abnormally low muscle tone) manifesting in the neonatal period and affecting the entire musculature.	UMLS:C1845123	hp.json	Hypotonia, neonatal, generalized|Generalised neonatal hypotonia|Generalized low muscle tone in neonate|Generalised low muscle tone in neonate|Hypotonia, neonatal, generalised	http://purl.obolibrary.org/obo/HP_0008935		
GO:0034111	biolink:BiologicalProcess	negative regulation of homotypic cell-cell adhesion	Any process that stops, prevents, or reduces the frequency, rate, or extent of homotypic cell-cell adhesion.		hp.json		http://purl.obolibrary.org/obo/GO_0034111		
GO:0034112	biolink:BiologicalProcess	positive regulation of homotypic cell-cell adhesion	Any process that activates or increases the frequency, rate, or extent of homotypic cell-cell adhesion.		hp.json		http://purl.obolibrary.org/obo/GO_0034112		
GO:0034109	biolink:BiologicalProcess	homotypic cell-cell adhesion	The attachment of a cell to a second cell of the identical type via adhesion molecules.		hp.json		http://purl.obolibrary.org/obo/GO_0034109		
HP:0008947	biolink:PhenotypicFeature	Infantile muscular hypotonia	Muscular hypotonia (abnormally low muscle tone) manifesting in infancy.	UMLS:C1860834	hp.json	Decreased muscle tone in infant|Hypotonia in infancy|Hypotonia early|Infantile hypotonia|Hypotonia, early	http://purl.obolibrary.org/obo/HP_0008947		
HP:0008946	biolink:PhenotypicFeature	Pelvic girdle amyotrophy	Atrophy of the muscles of the pelvic girdle (also known as hip girdle), i.e., the gluteal muscles, the lateral rotators, the adductors, the psoas major and the iliacus muscle.	UMLS:C4021528	hp.json	Hip girdle amyotrophy	http://purl.obolibrary.org/obo/HP_0008946		
GO:0034101	biolink:BiologicalProcess	erythrocyte homeostasis	Any process of regulating the production and elimination of erythrocytes within an organism.		hp.json	red blood cell homeostasis|RBC homeostasis	http://purl.obolibrary.org/obo/GO_0034101		
HP:0008948	biolink:PhenotypicFeature	Proximal upper limb amyotrophy	Muscular atrophy affecting proximally located muscles of the arms.	UMLS:C1866013	hp.json	Proximal muscle atrophy in upper limbs|Proximal upper limb muscle atrophy	http://purl.obolibrary.org/obo/HP_0008948		
GO:0034103	biolink:BiologicalProcess	regulation of tissue remodeling	Any process that modulates the frequency, rate, or extent of tissue remodeling.		hp.json		http://purl.obolibrary.org/obo/GO_0034103		
HP:0008942	biolink:PhenotypicFeature	Acute rhabdomyolysis	An acute form of rhabdomyolysis.	UMLS:C3807306	hp.json	Rhabdomyolysis, acute	http://purl.obolibrary.org/obo/HP_0008942		
GO:0034104	biolink:BiologicalProcess	negative regulation of tissue remodeling	Any process that stops, prevents, or reduces the frequency, rate, or extent of tissue remodeling.		hp.json		http://purl.obolibrary.org/obo/GO_0034104		
HP:0008945	biolink:PhenotypicFeature	Loss of ability to walk in early childhood		UMLS:C1835993	hp.json		http://purl.obolibrary.org/obo/HP_0008945		
GO:0034105	biolink:BiologicalProcess	positive regulation of tissue remodeling	Any process that activates or increases the frequency, rate, or extent of tissue remodeling.		hp.json		http://purl.obolibrary.org/obo/GO_0034105		
HP:0008944	biolink:PhenotypicFeature	Distal lower limb amyotrophy	Muscular atrophy of distal leg muscles.	UMLS:C1836451|UMLS:C1866863|UMLS:C3806644	hp.json	Lower limb degeneration|Lower limb atrophy|Muscle atrophy, lower limb, distal|Lower limb muscle hypotrophy|Lower leg amyotrophy	http://purl.obolibrary.org/obo/HP_0008944		
HP:0008940	biolink:PhenotypicFeature	Generalized lymphadenopathy	A generalized form of lymphadenopathy.	SNOMEDCT_US:274741002|UMLS:C0476486	hp.json	Generalised swelling of lymph nodes|Generalized swelling of lymph nodes|Generalised lymphadenopathy|Swollen lymph nodes affecting all regions of the body	http://purl.obolibrary.org/obo/HP_0008940		
GO:0048741	biolink:BiologicalProcess	skeletal muscle fiber development	The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.		hp.json	skeletal muscle fibre development|skeletal myofibre development|skeletal myofiber development	http://purl.obolibrary.org/obo/GO_0048741		
GO:0048742	biolink:BiologicalProcess	regulation of skeletal muscle fiber development	Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.		hp.json	regulation of skeletal muscle fibre development|regulation of skeletal myofibre development|regulation of skeletal myofiber development	http://purl.obolibrary.org/obo/GO_0048742		
GO:1902816	biolink:BiologicalProcess	regulation of protein localization to microtubule	Any process that modulates the frequency, rate or extent of protein localization to microtubule.		hp.json	regulation of protein localisation to microtubule	http://purl.obolibrary.org/obo/GO_1902816		
GO:1902817	biolink:BiologicalProcess	negative regulation of protein localization to microtubule	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule.		hp.json	inhibition of protein localisation to microtubule|downregulation of protein localisation to microtubule|down-regulation of protein localization to microtubule|down regulation of protein localization to microtubule|inhibition of protein localization to microtubule|down-regulation of protein localisation to microtubule|negative regulation of protein localisation to microtubule|downregulation of protein localization to microtubule|down regulation of protein localisation to microtubule	http://purl.obolibrary.org/obo/GO_1902817		
GO:0048743	biolink:BiologicalProcess	positive regulation of skeletal muscle fiber development	Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.		hp.json	up regulation of skeletal muscle fiber development|positive regulation of skeletal myofibre development|activation of skeletal muscle fiber development|stimulation of skeletal muscle fiber development|upregulation of skeletal muscle fiber development|positive regulation of skeletal myofiber development|positive regulation of skeletal muscle fibre development|up-regulation of skeletal muscle fiber development	http://purl.obolibrary.org/obo/GO_0048743		
GO:0048744	biolink:BiologicalProcess	negative regulation of skeletal muscle fiber development	Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.		hp.json	negative regulation of skeletal muscle fibre development|negative regulation of skeletal myofibre development|down-regulation of skeletal muscle fiber development|down regulation of skeletal muscle fiber development|negative regulation of skeletal myofiber development|downregulation of skeletal muscle fiber development|inhibition of skeletal muscle fiber development	http://purl.obolibrary.org/obo/GO_0048744		
GO:0048745	biolink:BiologicalProcess	smooth muscle tissue development	The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0048745		
GO:1902810	biolink:BiologicalProcess	negative regulation of skeletal muscle fiber differentiation	Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle fiber differentiation.		hp.json	down regulation of skeletal muscle fiber differentiation|inhibition of skeletal muscle fiber differentiation|downregulation of skeletal muscle fiber differentiation|down-regulation of skeletal muscle fiber differentiation	http://purl.obolibrary.org/obo/GO_1902810		
CHEBI:35418	biolink:ChemicalSubstance	N-acetylneuraminate	A ketoaldonate that is the conjugate base of N-acetylneuraminic acid, obtained by deprotonation of the carboxy group.	MetaCyc:N-ACETYLNEURAMINATE|Reaxys:9227329	hp.json	sialate|5-acetamido-3,5-dideoxy-D-galacto-non-2-ulopyranosonate|N-acetylneuraminate	http://purl.obolibrary.org/obo/CHEBI_35418		3_STAR
UBERON:0036013	biolink:AnatomicalEntity	intergluteal cleft	The line that divided the gluteal regions of the body.	FMA:20234	hp.json	natal cleft|crena analis|crena ani|anal cleft|crena interglutealis|intergluteal crease	http://purl.obolibrary.org/obo/UBERON_0036013		pheno_slim
GO:1902811	biolink:BiologicalProcess	positive regulation of skeletal muscle fiber differentiation	Any process that activates or increases the frequency, rate or extent of skeletal muscle fiber differentiation.		hp.json	up-regulation of skeletal muscle fiber differentiation|up regulation of skeletal muscle fiber differentiation|activation of skeletal muscle fiber differentiation|upregulation of skeletal muscle fiber differentiation	http://purl.obolibrary.org/obo/GO_1902811		
UBERON:0036014	biolink:AnatomicalEntity	gluteal sulcus	A horizontal crease formed by the inferior aspect of the buttocks and the posterior upper leg.	FMA:20233	hp.json	gluteal crease|horizontal gluteal crease|gluteal fold|sulcus glutealis	http://purl.obolibrary.org/obo/UBERON_0036014		pheno_slim
UBERON:0000060	biolink:AnatomicalEntity	anatomical wall	Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers.	EMAPA:25036|galen:Wall|FMA:82482	hp.json	wall|wall of organ|organ wall	http://purl.obolibrary.org/obo/UBERON_0000060		upper_level
UBERON:0000061	biolink:AnatomicalEntity	anatomical structure	Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome.	EMAPA:0|HAO:0000003|ZFA:0000037|SCTID:362889002|TAO:0000037|FMA:305751|GAID:781|VHOG:0001759|XAO:0003000|EHDAA2:0003003|MA:0003000|FBbt:00007001|TGMA:0001823|BILA:0000003|AEO:0000003|CARO:0000003|http://dbpedia.org/ontology/AnatomicalStructure|FMA:67135|MESH:D000825|AAO:0010825	hp.json	connected biological structure|biological structure	http://purl.obolibrary.org/obo/UBERON_0000061		upper_level
UBERON:0000062	biolink:AnatomicalEntity	organ	Anatomical structure that performs a specific function or group of functions [WP].	SCTID:272625005|UMLS:C0178784|EMAPA:35949|NCIT:C13018|EFO:0000634|OpenCyc:Mx4rwP3iWpwpEbGdrcN5Y29ycA|OpenCyc:Mx4rv5XMb5wpEbGdrcN5Y29ycA|MA:0003001|CARO:0020004|BIRNLEX:4|ENVO:01000162|Wikipedia:Organ_(anatomy)|FMA:67498|WBbt:0003760	hp.json	body organ|element|element|anatomical unit	http://purl.obolibrary.org/obo/UBERON_0000062		upper_level
UBERON:0000063	biolink:AnatomicalEntity	organ subunit	A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity.	FMA:86140	hp.json	organ segment|organ region with fixed fiat boundary|segment of organ	http://purl.obolibrary.org/obo/UBERON_0000063		upper_level
UBERON:0000068	biolink:AnatomicalEntity	embryo stage	A life cycle stage that starts with fertilization and ends with the fully formed embryo.	WBls:0000092|BilaDO:0000002|XAO:1000012|SCTID:296280003|WBls:0000102|WBls:0000003|FBdv:00005289|FMA:72652|MmusDv:0000002|EV:0300001|OGES:000022|OGES:000000|HsapDv:0000002	hp.json	embryonic stage|embryogenesis	http://purl.obolibrary.org/obo/UBERON_0000068		
GO:0048749	biolink:BiologicalProcess	compound eye development	The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.		hp.json	insect-type retina development	http://purl.obolibrary.org/obo/GO_0048749		
GO:0061727	biolink:BiologicalProcess	methylglyoxal catabolic process to lactate	The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate.		hp.json		http://purl.obolibrary.org/obo/GO_0061727		
UBERON:0000064	biolink:AnatomicalEntity	organ part	A multicellular structure that is a part of an organ.	SCTID:113343008|EFO:0000635|SCTID:91717005|AAO:0011124|FMA:82472|BIRNLEX:16	hp.json	cardinal organ part|regional part of organ	http://purl.obolibrary.org/obo/UBERON_0000064		non_informative|upper_level|efo_slim
UBERON:0000065	biolink:AnatomicalEntity	respiratory tract	Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts.	EHDAA2:0001606|EHDAA:2219|EHDAA:1568|FMA:265130|VHOG:0000393|SCTID:361110005|EMAPA:16737|OpenCyc:Mx4rvvM--pwpEbGdrcN5Y29ycA	hp.json		http://purl.obolibrary.org/obo/UBERON_0000065		
UBERON:0000066	biolink:AnatomicalEntity	fully formed stage	The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage.	BTO:0001043|BilaDO:0000004|EFO:0001272|FBdv:00005369|XtroDO:0000084|WBls:0000041	hp.json	fully formed animal stage|adult stage|juvenile-adult stage	http://purl.obolibrary.org/obo/UBERON_0000066		efo_slim
CHEBI:23443	biolink:ChemicalSubstance	cyclic amide			hp.json	cyclic amides|cyclic amide	http://purl.obolibrary.org/obo/CHEBI_23443		3_STAR
GO:0048753	biolink:BiologicalProcess	pigment granule organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule.		hp.json	pigment granule organization and biogenesis|pigment granule organisation	http://purl.obolibrary.org/obo/GO_0048753		goslim_pir
UBERON:0014693	biolink:AnatomicalEntity	inferior alveolar artery		FMA:49695	hp.json		http://purl.obolibrary.org/obo/UBERON_0014693		human_reference_atlas
GO:0048754	biolink:BiologicalProcess	branching morphogenesis of an epithelial tube	The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.		hp.json	tubulogenesis	http://purl.obolibrary.org/obo/GO_0048754		
GO:0048755	biolink:BiologicalProcess	branching morphogenesis of a nerve	The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron).		hp.json		http://purl.obolibrary.org/obo/GO_0048755		
UBERON:0014699	biolink:AnatomicalEntity	extraembryonic venous system	A venous system that overlaps a umbilical cord and is part of a entire extraembryonic component.	EHDAA2:0000479|VHOG:0000282|EMAPA:16374	hp.json		http://purl.obolibrary.org/obo/UBERON_0014699		
UBERON:0014695	biolink:AnatomicalEntity	deep auricular artery	The deep auricular artery often arises in common with the anterior tympanic artery. It ascends in the substance of the parotid gland, behind the temporomandibular articulation, pierces the cartilaginous or bony wall of the external acoustic meatus, and supplies its cuticular lining and the outer surface of the tympanic membrane. It gives a branch to the temporomandibular joint.	FMA:49689	hp.json		http://purl.obolibrary.org/obo/UBERON_0014695		human_reference_atlas
UBERON:0000057	biolink:AnatomicalEntity	urethra	The fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening.	GAID:390|MIAA:0000121|NCIT:C12417|MA:0000379|FMA:19667|VHOG:0001264|UMLS:C0041967|EMAPA:30901|CALOHA:TS-1132|galen:Urethra|EFO:0000931|XAO:0000153|BTO:0001426|OpenCyc:Mx4rvVjkypwpEbGdrcN5Y29ycA|MESH:D014521|EV:0100099|MAT:0000121	hp.json		http://purl.obolibrary.org/obo/UBERON_0000057		efo_slim|uberon_slim|major_organ|organ_slim|pheno_slim
UBERON:0000058	biolink:AnatomicalEntity	duct	A tubular structure that transports secreted or excreted substances.	FMA:30320|UMLS:C0687028|NCIT:C12948|galen:Duct|ZFA:0005171|FBbt:00100314|SCTID:91726008|TAO:0005171|Wikipedia:Duct_(anatomy)|XAO:0004000|AAO:0011123	hp.json	ducts|exocrine duct|exocrine gland duct|anatomical duct	http://purl.obolibrary.org/obo/UBERON_0000058		grouping_class
CHEBI:23449	biolink:ChemicalSubstance	cyclic peptide			hp.json	peptide cyclique|Cyclopeptid|Zyklopeptid|peptido ciclico|cyclic peptides	http://purl.obolibrary.org/obo/CHEBI_23449		3_STAR
UBERON:0000059	biolink:AnatomicalEntity	large intestine	A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong].	CALOHA:TS-1306|EV:0100077|AAO:0010396|MIAA:0000046|GAID:306|MESH:D007420|BTO:0000706|SCTID:181254001|VHOG:0000054|MA:0000333|UMLS:C0021851|galen:LargeIntestine|FMA:7201|NCIT:C12379|XAO:0000131|Wikipedia:Large_intestine_(anatomy)|EFO:0000840|OpenCyc:Mx4rvVkF5pwpEbGdrcN5Y29ycA|EMAPA:19252	hp.json	intestinum crassum	http://purl.obolibrary.org/obo/UBERON_0000059		efo_slim|human_reference_atlas|major_organ|organ_slim|pheno_slim
UBERON:0024045	biolink:AnatomicalEntity	white matter of the cerebellar cortex	White matter that lies deep to the granular cell layer of the cerebellar cortex. It contains afferents to the cerebellar cortex and axons that run between the cerebellar cortex and the deep cerebellar nuclei.	NLXANAT:20081249	hp.json	white matter of the cerebellar cortex|white matter of the cerebellar cortex	http://purl.obolibrary.org/obo/UBERON_0024045		
UBERON:0000053	biolink:AnatomicalEntity	macula lutea	An oval area in the retina, usually located temporal to the posterior pole of the eye and slightly below the level of the optic disk. It is characterized by the presence of a yellow pigment diffusely permeating the inner layers, contains the fovea centralis in its center, and provides the best phototopic visual acuity. It is devoid of retinal blood vessels, except in its periphery, and receives nourishment from the choriocapillaris of the choroid. (From Cline et al., Dictionary of Visual Science, 4th ed).	MA:0001306|UMLS:C0450295|MESH:D008266|EV:0100349|BIRNLEX:2540|GAID:909|UMLS:C0450295|FMA:58637|EMAPA:36516|NCIT:C33044|UMLS:C1284755|NCIT:C26464|BTO:0003015	hp.json	macula flava retinae|macula retinae|macula|maculae	http://purl.obolibrary.org/obo/UBERON_0000053		uberon_slim|pheno_slim
UBERON:0000054	biolink:AnatomicalEntity	macula	Thickened areas of the saccule or utricle where the termination of the vestibular nerve occurs[MESH,modified].	MESH:D008267|GAID:777|ZFA:0000386|TAO:0000386	hp.json	sensory macula|maculae|sensory patch|macula|acoustic maculae|acoustic macula	http://purl.obolibrary.org/obo/UBERON_0000054		uberon_slim|pheno_slim
UBERON:0000055	biolink:AnatomicalEntity	vessel	A tubular structure that contains, conveys body fluid, such as blood or lymph.		hp.json		http://purl.obolibrary.org/obo/UBERON_0000055		grouping_class|pheno_slim|human_reference_atlas
UBERON:0000056	biolink:AnatomicalEntity	ureter	Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs.	EV:0100097|GAID:438|UMLS:C0041951|FMA:9704|MIAA:0000120|EHDAA:9341|NCIT:C12416|BTO:0001409|EMAPA:17950|MA:0000378|XAO:0000144|EHDAA2:0002139|VHOG:0000605|MESH:D014513|EFO:0000930|CALOHA:TS-1084|galen:Ureter|OpenCyc:Mx4rvhmm6JwpEbGdrcN5Y29ycA|AAO:0010254|MAT:0000120	hp.json	metanephric duct	http://purl.obolibrary.org/obo/UBERON_0000056		uberon_slim|major_organ|organ_slim|pheno_slim|efo_slim|human_reference_atlas
GO:0048762	biolink:BiologicalProcess	mesenchymal cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.		hp.json		http://purl.obolibrary.org/obo/GO_0048762		
UBERON:0014680	biolink:AnatomicalEntity	distal interphalangeal joint of digit 5	A distal interphalangeal joint that is part of a digit 5.	NCIT:C102294	hp.json	distal interphalangeal joint 5|distal interphalangeal joint of digit V	http://purl.obolibrary.org/obo/UBERON_0014680		
GO:1902838	biolink:BiologicalProcess	regulation of nuclear migration along microtubule	Any process that modulates the frequency, rate or extent of nuclear migration along microtubule.		hp.json	regulation of transport of nucleus, microtubule-mediated|regulation of nucleus migration|regulation of microtubule-mediated nuclear migration|regulation of microtubule cytoskeleton-dependent nuclear positioning|regulation of nuclear migration, microtubule-mediated|regulation of nuclear movement, microtubule-mediated|regulation of transport of nucleus by microtubules|regulation of microtubule-dependent nuclear positioning|regulation of microtubule cytoskeleton-dependent nucleus positioning|regulation of microtubule-dependent nucleus positioning	http://purl.obolibrary.org/obo/GO_1902838		
GO:1902839	biolink:BiologicalProcess	negative regulation of nuclear migration along microtubule	Any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule.		hp.json	negative regulation of nuclear migration, microtubule-mediated|downregulation of transport of nucleus, microtubule-mediated|down-regulation of nuclear migration, microtubule-mediated|downregulation of microtubule-mediated nuclear migration|down-regulation of microtubule-dependent nuclear positioning|negative regulation of microtubule-dependent nuclear positioning|down-regulation of nuclear migration along microtubule|downregulation of microtubule cytoskeleton-dependent nuclear positioning|down regulation of nuclear migration, microtubule-mediated|down regulation of microtubule-dependent nuclear positioning|down-regulation of microtubule-dependent nucleus positioning|down regulation of nuclear migration along microtubule|negative regulation of microtubule-dependent nucleus positioning|downregulation of transport of nucleus by microtubules|down regulation of transport of nucleus, microtubule-mediated|inhibition of transport of nucleus, microtubule-mediated|down regulation of microtubule-mediated nuclear migration|downregulation of microtubule cytoskeleton-dependent nucleus positioning|inhibition of microtubule-mediated nuclear migration|inhibition of nuclear migration, microtubule-mediated|down regulation of microtubule cytoskeleton-dependent nuclear positioning|negative regulation of transport of nucleus, microtubule-mediated|downregulation of nuclear migration, microtubule-mediated|inhibition of microtubule-dependent nuclear positioning|inhibition of microtubule cytoskeleton-dependent nuclear positioning|down-regulation of transport of nucleus, microtubule-mediated|inhibition of nuclear migration along microtubule|down regulation of microtubule-dependent nucleus positioning|downregulation of nuclear migration along microtubule|down regulation of transport of nucleus by microtubules|negative regulation of microtubule-mediated nuclear migration|down-regulation of microtubule-mediated nuclear migration|downregulation of microtubule-dependent nuclear positioning|negative regulation of microtubule cytoskeleton-dependent nuclear positioning|down regulation of microtubule cytoskeleton-dependent nucleus positioning|inhibition of transport of nucleus by microtubules|down-regulation of microtubule cytoskeleton-dependent nuclear positioning|inhibition of microtubule-dependent nucleus positioning|inhibition of microtubule cytoskeleton-dependent nucleus positioning|downregulation of microtubule-dependent nucleus positioning|down-regulation of transport of nucleus by microtubules|negative regulation of transport of nucleus by microtubules|negative regulation of microtubule cytoskeleton-dependent nucleus positioning|down-regulation of microtubule cytoskeleton-dependent nucleus positioning	http://purl.obolibrary.org/obo/GO_1902839		
UBERON:0014687	biolink:AnatomicalEntity	temporal sulcus	Any of three grooves in the temporal lobe including the inferior, middle, and superior temporal sulci.	NCIT:C33744|HBA:9377	hp.json	temporal lobe sulcus|temporal lobe sulci	http://purl.obolibrary.org/obo/UBERON_0014687		
UBERON:0014686	biolink:AnatomicalEntity	angular vein	The angular vein formed by the junction of the frontal vein and supraorbital vein, runs obliquely downward, on the side of the root of the nose, to the level of the lower margin of the orbit, where it becomes the anterior facial vein. It receives the external nasal veins of the ala nasi, and communicates with the superior ophthalmic vein through the nasofrontal vein, thus establishing an important anastomosis between the anterior facial vein and the cavernous sinus.	FMA:50893	hp.json		http://purl.obolibrary.org/obo/UBERON_0014686		human_reference_atlas
UBERON:0000047	biolink:AnatomicalEntity	simple eye	An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity.	TGMA:0000729|Wikipedia:Eye#Simple_eyes	hp.json		http://purl.obolibrary.org/obo/UBERON_0000047		uberon_slim|grouping_class
UBERON:0000042	biolink:AnatomicalEntity	serous membrane	Multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer.	SCTID:362878009|Wikipedia:Serous_membrane|MESH:D012704|GAID:19|ZFA:0005425|TAO:0005425|NCIT:C13169|UMLS:C0036760|FMA:9581	hp.json	tunica serosa|serosa|wall of serous sac|serosa	http://purl.obolibrary.org/obo/UBERON_0000042		uberon_slim|vertebrate_core
UBERON:0000043	biolink:AnatomicalEntity	tendon	Dense regular connective tissue that connects muscle to bone[VSAO].	galen:Tendon|SCTID:256667004|EMAPA:35854|OpenCyc:Mx4rvVjefJwpEbGdrcN5Y29ycA|ZFA:0005647|MA:0000115|VHOG:0001286|VSAO:0000073|FMA:9721|EV:0100149|EHDAA2:0003091|CALOHA:TS-1021|GAID:276|MESH:D013710|Wikipedia:Tendon|AEO:0000091|XAO:0000173|UMLS:C0039508|NCIT:C13045|BTO:0001356	hp.json	sinew|sinew|tendo|tendo	http://purl.obolibrary.org/obo/UBERON_0000043		uberon_slim|pheno_slim
UBERON:0000045	biolink:AnatomicalEntity	ganglion	A biological tissue mass, most commonly a mass of nerve cell bodies.	NCIT:C12719|BTO:0000497|EV:0100372|NLXANAT:100302|AEO:0000135|MIAA:0000343|ZFA:0000190|Wikipedia:Ganglion|MA:0002406|BAMS:G|VHOG:0000156|UMLS:C0017067|TGMA:0001016|TAO:0000190|WBbt:0005189|FMA:5884|CALOHA:TS-0397|MAT:0000207|AAO:0010426|EHDAA:2897|EFO:0000899|EMAPA:32846|MIAA:0000207|MESH:D005724|EHDAA:5621|MAT:0000343|XAO:0000209|EHDAA:4662|EHDAA2:0003135|EHDAA:918	hp.json	ganglia|neural ganglion	http://purl.obolibrary.org/obo/UBERON_0000045		efo_slim|uberon_slim|vertebrate_core|pheno_slim
GO:0046110	biolink:BiologicalProcess	xanthine metabolic process	The chemical reactions and pathways involving xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.		hp.json	xanthine metabolism	http://purl.obolibrary.org/obo/GO_0046110		
UBERON:0014670	biolink:AnatomicalEntity	distal interphalangeal joint of manual digit 4		FMA:35340	hp.json	distal interphalangeal joint of ring finger|distal interphalangeal joint of manual digit IV	http://purl.obolibrary.org/obo/UBERON_0014670		pheno_slim
UBERON:0014671	biolink:AnatomicalEntity	distal interphalangeal joint of manural digit 5		FMA:35343	hp.json	distal interphalangeal joint of little finger|distal interphalangeal joint of manural digit V	http://purl.obolibrary.org/obo/UBERON_0014671		
UBERON:0000029	biolink:AnatomicalEntity	lymph node	Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph.	galen:Lymphnode|ZFA_RETIRED:0005318|MAT:0000442|GAID:947|EFO:0000872|TAO_RETIRED:0005318|BTO:0000784|CALOHA:TS-0579|EMAPA:35523|EV:0100050|MA:0000139|UMLS:C0024204|MESH:D008198|NCIT:C12745|VHOG:0001273|OpenCyc:Mx4rwLPqLpwpEbGdrcN5Y29ycA|NCIT:C33027|FMA:5034	hp.json	lymph gland|nodus lymphaticus	http://purl.obolibrary.org/obo/UBERON_0000029		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|vertebrate_core
CHEBI:35406	biolink:ChemicalSubstance	oxoanion	An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen.		hp.json	oxoanion|oxoacid anions|oxoanions	http://purl.obolibrary.org/obo/CHEBI_35406		3_STAR
UBERON:0014677	biolink:AnatomicalEntity	distal interphalangeal joint of digit 2	A distal interphalangeal joint that is part of a digit 2.	NCIT:C102291	hp.json	distal interphalangeal joint of digit II|distal interphalangeal joint 2	http://purl.obolibrary.org/obo/UBERON_0014677		
UBERON:0014679	biolink:AnatomicalEntity	distal interphalangeal joint of digit 4	A distal interphalangeal joint that is part of a digit 4.	NCIT:C102293	hp.json	distal interphalangeal joint of digit IV|distal interphalangeal joint 4	http://purl.obolibrary.org/obo/UBERON_0014679		
UBERON:0014672	biolink:AnatomicalEntity	distal interphalangeal joint of pedal digit 2		FMA:35369	hp.json	distal interphalangeal joint of second toe|distal interphalangeal joint of second digit of foot|distal interphalangeal joint of pedal digit II	http://purl.obolibrary.org/obo/UBERON_0014672		pheno_slim
GO:1902840	biolink:BiologicalProcess	positive regulation of nuclear migration along microtubule	Any process that activates or increases the frequency, rate or extent of nuclear migration along microtubule.		hp.json	activation of transport of nucleus by microtubules|up-regulation of transport of nucleus by microtubules|upregulation of microtubule-dependent nucleus positioning|up-regulation of microtubule cytoskeleton-dependent nucleus positioning|activation of microtubule cytoskeleton-dependent nucleus positioning|up-regulation of nuclear migration, microtubule-mediated|upregulation of transport of nucleus, microtubule-mediated|up-regulation of nuclear migration along microtubule|upregulation of microtubule-mediated nuclear migration|up-regulation of microtubule-dependent nuclear positioning|upregulation of microtubule cytoskeleton-dependent nuclear positioning|up regulation of nuclear migration, microtubule-mediated|positive regulation of transport of nucleus, microtubule-mediated|up regulation of microtubule-dependent nuclear positioning|upregulation of transport of nucleus by microtubules|activation of nuclear migration, microtubule-mediated|up-regulation of microtubule-dependent nucleus positioning|up regulation of nuclear migration along microtubule|upregulation of microtubule cytoskeleton-dependent nucleus positioning|positive regulation of microtubule-mediated nuclear migration|activation of microtubule-dependent nuclear positioning|positive regulation of nuclear migration, microtubule-mediated|activation of nuclear migration along microtubule|positive regulation of microtubule cytoskeleton-dependent nuclear positioning|up regulation of transport of nucleus, microtubule-mediated|positive regulation of microtubule-dependent nuclear positioning|up regulation of microtubule-dependent nucleus positioning|up regulation of microtubule-mediated nuclear migration|up regulation of microtubule cytoskeleton-dependent nuclear positioning|activation of microtubule-dependent nucleus positioning|positive regulation of transport of nucleus by microtubules|positive regulation of microtubule cytoskeleton-dependent nucleus positioning|upregulation of nuclear migration, microtubule-mediated|up-regulation of transport of nucleus, microtubule-mediated|positive regulation of microtubule-dependent nucleus positioning|activation of transport of nucleus, microtubule-mediated|up-regulation of microtubule-mediated nuclear migration|up regulation of transport of nucleus by microtubules|activation of microtubule-mediated nuclear migration|upregulation of microtubule-dependent nuclear positioning|upregulation of nuclear migration along microtubule|up regulation of microtubule cytoskeleton-dependent nucleus positioning|up-regulation of microtubule cytoskeleton-dependent nuclear positioning|activation of microtubule cytoskeleton-dependent nuclear positioning	http://purl.obolibrary.org/obo/GO_1902840		
GO:0048770	biolink:CellularComponent	pigment granule	A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.		hp.json		http://purl.obolibrary.org/obo/GO_0048770		
UBERON:0014674	biolink:AnatomicalEntity	distal interphalangeal joint of pedal digit 4		FMA:35387	hp.json	distal interphalangeal joint of fourth toe|distal interphalangeal joint of pedal digit IV|distal interphalangeal joint of fourth digit of foot	http://purl.obolibrary.org/obo/UBERON_0014674		pheno_slim
GO:0046112	biolink:BiologicalProcess	nucleobase biosynthetic process	The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid.		hp.json	nucleobase anabolism|nucleobase biosynthesis|nucleobase synthesis|nucleobase formation	http://purl.obolibrary.org/obo/GO_0046112		
GO:0048771	biolink:BiologicalProcess	tissue remodeling	The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.		hp.json		http://purl.obolibrary.org/obo/GO_0048771		goslim_pir
UBERON:0014675	biolink:AnatomicalEntity	distal interphalangeal joint of pedal digit 5		FMA:35393	hp.json	distal interphalangeal joint of fifth digit of foot|distal interphalangeal joint of pedal digit V|distal interphalangeal joint of little toe|distal interphalangeal joint of fifth toe	http://purl.obolibrary.org/obo/UBERON_0014675		pheno_slim
UBERON:0000030	biolink:AnatomicalEntity	lamina propria	A thin layer of loose connective tissue which lies beneath the epithelium and together with the epithelium constitutes the mucosa[WP]. The lamina propria contains capillaries and a central lacteal (lymph vessel) in the small intestine, as well as lymphoid tissue. Lamina propria also contains glands with the ducts opening on to the mucosal epithelium, that secrete mucus and serous secretions.	SCTID:298225002|BTO:0002330|Wikipedia:Lamina_propria|FMA:62517|NCIT:C32918|UMLS:C1179187	hp.json	lamina propria mucosa|lamina propria mucosae|tunica propria	http://purl.obolibrary.org/obo/UBERON_0000030		uberon_slim
UBERON:0000031	biolink:AnatomicalEntity	lamina propria of trachea	A lamina propria that is part of a respiratory airway.	EMAPA:35877|MA:0001858|FMA:265157|UMLS:C1710457|NCIT:C49305	hp.json	trachea lamina propria|lamina propria mucosa of windpipe|windpipe lamina propria|lamina propria mucosa of trachea|tracheal lamina propria|windpipe lamina propria mucosa|lamina propria mucosae of trachea|lamina propria mucosae of windpipe|trachea lamina propria mucosa|lamina propria of windpipe|trachea lamina propria mucosae|windpipe lamina propria mucosae	http://purl.obolibrary.org/obo/UBERON_0000031		
UBERON:0000033	biolink:AnatomicalEntity	head	The head is the anterior-most division of the body [GO].	BILA:0000115|SCTID:302548004|UMLS:C0018670|VHOG:0001644|MESH:D006257|CALOHA:TS-0436|Wikipedia:Head|MAT:0000294|SPD:0000016|NCIT:C12419|OpenCyc:Mx4rEOLm4rgPEdmAAAACs6hRjg|OpenCyc:Mx4rvVi6YJwpEbGdrcN5Y29ycA|FBbt:00000004|GAID:61|BTO:0000282|MIAA:0000294|TGMA:0000002|galen:Head|ZFA:0001114|UMLS:C0018670|EMAPA:31858|HAO:0000397|BIRNLEX:1230|WBbt:0005739|EHDAA2:0003106|TAO:0001114|MA:0000023|AAO:0010335|EFO:0000964|XAO:0003024|FMA:7154|AEO:0000106	hp.json	head (volume)|adult head|cephalic area	http://purl.obolibrary.org/obo/UBERON_0000033		efo_slim|uberon_slim|vertebrate_core|pheno_slim
UBERON:0012082	biolink:AnatomicalEntity	bronchial lumen	An anatomical cavity that is part of a bronchus.	FMA:62646	hp.json	bronchial lumen|lumen of bronchus	http://purl.obolibrary.org/obo/UBERON_0012082		
UBERON:0012081	biolink:AnatomicalEntity	patella pre-cartilage condensation	A pre-cartilage condensation that has the potential to develop into a patella.	EMAPA:18510	hp.json		http://purl.obolibrary.org/obo/UBERON_0012081		
UBERON:0012080	biolink:AnatomicalEntity	patella cartilage element	A cartilaginous condensation that has the potential to develop into a patella.	EMAPA:19140	hp.json		http://purl.obolibrary.org/obo/UBERON_0012080		
GO:1902850	biolink:BiologicalProcess	microtubule cytoskeleton organization involved in mitosis	Any microtubule cytoskeleton organization that is involved in mitosis.		hp.json	microtubule dynamics involved in mitosis|microtubule cytoskeleton organization and biogenesis involved in mitosis|microtubule cytoskeleton organisation involved in mitosis	http://purl.obolibrary.org/obo/GO_1902850		
GO:0097711	biolink:BiologicalProcess	ciliary basal body-plasma membrane docking	The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.	Reactome:R-HSA-5620912.1	hp.json	anchoring of the basal body to the plasma membrane|ciliary basal body docking	http://purl.obolibrary.org/obo/GO_0097711		
GO:0097712	biolink:BiologicalProcess	vesicle targeting, trans-Golgi to periciliary membrane compartment	The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.		hp.json		http://purl.obolibrary.org/obo/GO_0097712		
UBERON:0012071	biolink:AnatomicalEntity	palate bone	Any bone that is part of a palate.	EMAPA:37930|UMLS:C1518857|NCIT:C33248	hp.json	palatal bone	http://purl.obolibrary.org/obo/UBERON_0012071		pheno_slim
UBERON:0012070	biolink:AnatomicalEntity	palatal tooth	A tooth that is on the roof of the mouth.		hp.json	palatal teeth	http://purl.obolibrary.org/obo/UBERON_0012070		
GO:0048799	biolink:BiologicalProcess	animal organ maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an animal organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions.		hp.json		http://purl.obolibrary.org/obo/GO_0048799		
UBERON:0012075	biolink:AnatomicalEntity	replacement bone	Bone that forms as a replacement of another structural tissue.	ZFA:0001628|TAO:0001637|AAO:0010768	hp.json	replacement bones	http://purl.obolibrary.org/obo/UBERON_0012075		
UBERON:0012074	biolink:AnatomicalEntity	bony part of hard palate	A subdivision of skeletal system that subdivision_of a hard palate.	EMAPA:37444|FMA:59857	hp.json	palatum osseum|bony palate|hard palate skeleton	http://purl.obolibrary.org/obo/UBERON_0012074		pheno_slim
GO:1902867	biolink:BiologicalProcess	negative regulation of retina development in camera-type eye	Any process that stops, prevents or reduces the frequency, rate or extent of retina development in camera-type eye.		hp.json	down regulation of retina development in camera-type eye|downregulation of retina development in camera-style eye|inhibition of retina development in camera-type eye|downregulation of retina development in camera-type eye|inhibition of retinal development|down regulation of retina development in camera-style eye|inhibition of retina development in camera-style eye|down-regulation of retinal development|down-regulation of retina development in camera-style eye|negative regulation of retinal development|negative regulation of retina development in camera-style eye|down regulation of retinal development|down-regulation of retina development in camera-type eye|downregulation of retinal development	http://purl.obolibrary.org/obo/GO_1902867		
HGNC:9606	biolink:Gene	PTH (human)	A protein coding gene PTH in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9606		
UBERON:0012073	biolink:AnatomicalEntity	tooth of palatine bone	A tooth that is attached to a palatine bone.		hp.json	palatine tooth|palatine teeth	http://purl.obolibrary.org/obo/UBERON_0012073		
GO:1902868	biolink:BiologicalProcess	positive regulation of retina development in camera-type eye	Any process that activates or increases the frequency, rate or extent of retina development in camera-type eye.		hp.json	up-regulation of retina development in camera-style eye|up regulation of retinal development|activation of retina development in camera-style eye|positive regulation of retinal development|up-regulation of retina development in camera-type eye|upregulation of retinal development|up regulation of retina development in camera-type eye|upregulation of retina development in camera-style eye|activation of retina development in camera-type eye|activation of retinal development|positive regulation of retina development in camera-style eye|upregulation of retina development in camera-type eye|up-regulation of retinal development|up regulation of retina development in camera-style eye	http://purl.obolibrary.org/obo/GO_1902868		
UBERON:0012072	biolink:AnatomicalEntity	palatal part of dermatocranium			hp.json	palatal series|dermatocranium, palatal series	http://purl.obolibrary.org/obo/UBERON_0012072		
GO:1902865	biolink:BiologicalProcess	positive regulation of embryonic camera-type eye development	Any process that activates or increases the frequency, rate or extent of embryonic camera-type eye development.		hp.json	up regulation of embryonic camera-type eye development|activation of embryonic camera-type eye development|up regulation of embryonic eye development|activation of embryonic eye development|positive regulation of embryonic eye development|upregulation of embryonic camera-type eye development|upregulation of embryonic eye development|up-regulation of embryonic camera-type eye development|up-regulation of embryonic eye development	http://purl.obolibrary.org/obo/GO_1902865		
GO:1902866	biolink:BiologicalProcess	regulation of retina development in camera-type eye	Any process that modulates the frequency, rate or extent of retina development in camera-type eye.		hp.json	regulation of retina development in camera-style eye|regulation of retinal development	http://purl.obolibrary.org/obo/GO_1902866		
GO:1902863	biolink:BiologicalProcess	regulation of embryonic camera-type eye development	Any process that modulates the frequency, rate or extent of embryonic camera-type eye development.		hp.json	regulation of embryonic eye development	http://purl.obolibrary.org/obo/GO_1902863		
GO:0046137	biolink:BiologicalProcess	negative regulation of vitamin metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.		hp.json	downregulation of vitamin metabolic process|inhibition of vitamin metabolic process|down-regulation of vitamin metabolic process|negative regulation of vitamin metabolism|down regulation of vitamin metabolic process	http://purl.obolibrary.org/obo/GO_0046137		
GO:1902864	biolink:BiologicalProcess	negative regulation of embryonic camera-type eye development	Any process that stops, prevents or reduces the frequency, rate or extent of embryonic camera-type eye development.		hp.json	down-regulation of embryonic camera-type eye development|down-regulation of embryonic eye development|negative regulation of embryonic eye development|down regulation of embryonic camera-type eye development|down regulation of embryonic eye development|inhibition of embryonic camera-type eye development|downregulation of embryonic camera-type eye development|inhibition of embryonic eye development|downregulation of embryonic eye development	http://purl.obolibrary.org/obo/GO_1902864		
UBERON:0012076	biolink:AnatomicalEntity	tibiotalar joint	A skeletal joint that connects a tibia and connects a talus.		hp.json	ankle joint|talotibial joint|tibioastragalar joint	http://purl.obolibrary.org/obo/UBERON_0012076		
GO:0046136	biolink:BiologicalProcess	positive regulation of vitamin metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.		hp.json	positive regulation of vitamin metabolism|up-regulation of vitamin metabolic process|up regulation of vitamin metabolic process|activation of vitamin metabolic process|stimulation of vitamin metabolic process|upregulation of vitamin metabolic process	http://purl.obolibrary.org/obo/GO_0046136		
UBERON:0000093	biolink:AnatomicalEntity	sulcus	A depression or fissure in the surface of an organ.		hp.json		http://purl.obolibrary.org/obo/UBERON_0000093		grouping_class|non_informative
UBERON:0000094	biolink:AnatomicalEntity	membrane organ	Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA].	FMA:7145	hp.json	membrane|membrane of organ	http://purl.obolibrary.org/obo/UBERON_0000094		
UBERON:0000095	biolink:AnatomicalEntity	cardiac neural crest	Portion of neural crest that develops from the dorsal neural tube. It overlaps the vagal neural crest and migrates to populate the pharyngeal arches 3, 4 and 6 (producing structures in the head) and to the heart, forming connective tissue that separates the great vessels of the heart. [Wikipedia].	ZFA:0001648|TAO:0002173|XAO:0004190|Wikipedia:Cardiac_neural_crest	hp.json	cardiac neural crest complex|cardiac neural crest complex|complexus cristae neuralis cardiacus|complexus cristae neuralis cardiacus	http://purl.obolibrary.org/obo/UBERON_0000095		vertebrate_core
UBERON:0000091	biolink:AnatomicalEntity	bilaminar disc	A flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc.	FMA:293863|NCIT:C34112|Wikipedia:Bilaminar_disc|UMLS:C1283997	hp.json	bilaminar disk|embryonic shield|bilaminary embryonic disc|germinal disc|embryonic disc|bilaminar disk|bilaminary germ disc|germinal disk	http://purl.obolibrary.org/obo/UBERON_0000091		pheno_slim|early_development
UBERON:0000092	biolink:AnatomicalEntity	post-embryonic stage	Stage succeeding embryo, including mature structure.	WBls:0000022|OGES:000014|OGES:000024|OGES:000010|WBls:0000093|BilaDO:0000003|WBls:0000103	hp.json	postembryonic stage|postembryonic|post-hatching stage	http://purl.obolibrary.org/obo/UBERON_0000092		
GO:0097722	biolink:BiologicalProcess	sperm motility	Any process involved in the controlled movement of a sperm cell.		hp.json	sperm movement	http://purl.obolibrary.org/obo/GO_0097722		gocheck_do_not_annotate
GO:1902876	biolink:BiologicalProcess	negative regulation of embryonic pattern specification	Any process that stops, prevents or reduces the frequency, rate or extent of embryonic pattern specification.		hp.json	down-regulation of embryonic pattern specification|downregulation of ventral/lateral system|down regulation of embryonic pattern specification|down regulation of ventral/lateral system|inhibition of embryonic pattern specification|down-regulation of ventral/lateral system|downregulation of embryonic pattern specification|negative regulation of ventral/lateral system|inhibition of ventral/lateral system	http://purl.obolibrary.org/obo/GO_1902876		
GO:1902877	biolink:BiologicalProcess	positive regulation of embryonic pattern specification	Any process that activates or increases the frequency, rate or extent of embryonic pattern specification.		hp.json	up-regulation of ventral/lateral system|upregulation of embryonic pattern specification|activation of ventral/lateral system|upregulation of ventral/lateral system|up-regulation of embryonic pattern specification|up regulation of embryonic pattern specification|positive regulation of ventral/lateral system|activation of embryonic pattern specification|up regulation of ventral/lateral system	http://purl.obolibrary.org/obo/GO_1902877		
GO:0046148	biolink:BiologicalProcess	pigment biosynthetic process	The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, e.g. melanin.		hp.json	pigment biosynthesis|pigment synthesis|pigment formation|pigment anabolism	http://purl.obolibrary.org/obo/GO_0046148		
GO:1902875	biolink:BiologicalProcess	regulation of embryonic pattern specification	Any process that modulates the frequency, rate or extent of embryonic pattern specification.		hp.json	regulation of ventral/lateral system|regulation of embryonic pattern formation|regulation of embryonic pattern biosynthesis	http://purl.obolibrary.org/obo/GO_1902875		
UBERON:0012069	biolink:AnatomicalEntity	epithelium-associated lymphoid tissue		FMA:62811	hp.json		http://purl.obolibrary.org/obo/UBERON_0012069		
UBERON:0000083	biolink:AnatomicalEntity	mesonephric tubule	A mesonephric tubule is an epithelial tube that is part of the mesonephros[GO]. Genital ridge that is next to the mesonephros[WP].	AAO:0010389|EHDAA2:0001134|EMAPA:16747|VHOG:0000500|XAO:0000148	hp.json	renal tubules|tubuli mesonephrici	http://purl.obolibrary.org/obo/UBERON_0000083		
UBERON:0000084	biolink:AnatomicalEntity	ureteric bud	An epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme[MP].	EHDAA:3091|BTO:0001646|UMLS:C1284058|EMAPA:17209|EHDAA:5917|EHDAA2:0002140|VHOG:0000541|NCIT:C34207	hp.json	ureteric ampulla|metanephric bud|metanephric diverticulum|gemma ureterica|ureteric diverticulum|diverticulum metanephricum|diverticulum	http://purl.obolibrary.org/obo/UBERON_0000084		pheno_slim
UBERON:0000085	biolink:AnatomicalEntity	morula	A spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum.	Wikipedia:Morula|EHDAA2:0000005|NCIT:C34212|FMA:292334|UMLS:C0026573|SCTID:361474003|MESH:D009028|GAID:1295|BTO:0001508	hp.json	morula (2-16 cells)	http://purl.obolibrary.org/obo/UBERON_0000085		pheno_slim
UBERON:0000080	biolink:AnatomicalEntity	mesonephros	The second stage of the kidney. It serves as the main excretory organ of aquatic vertebrates and as a temporary embryonic kidney in higher vertebrates. It is composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo.	XAO:0000141|NCIT:C26467|ZFA:0000529|EHDAA:1581|CALOHA:TS-0624|VHOG:0000038|BTO:0001542|AAO:0010384|TAO:0000529|UMLS:C0025492|EHDAA2:0001130|EFO:0000928|EMAPA:16744|EHDAA:5903|FMA:72171|GAID:1308|MESH:D001755	hp.json	mesonephroi|amphibian adult kidney|mesonephric kidney|opisthonephros|opisto nephros|corpus Wolffi|Wolffian body|opistonephros|middle kidney	http://purl.obolibrary.org/obo/UBERON_0000080		organ_slim|pheno_slim|efo_slim|vertebrate_core
UBERON:0000081	biolink:AnatomicalEntity	metanephros	In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO].	EHDAA2:0001137|EMAPA:17373|EHDAA:3089|BTO:0001543|VHOG:0000039|NCIT:C34209|FMA:72172|UMLS:C0231049|EMAPA_RETIRED:17207|EHDAA:5911	hp.json	hind kidney|metanephric kidney|metanephron|definite kidney|definitive kidney	http://purl.obolibrary.org/obo/UBERON_0000081		organ_slim|pheno_slim
UBERON:0000086	biolink:AnatomicalEntity	zona pellucida	A glycoprotein membrane surrounding the plasma membrane of an oocyte. It is a vital constitutive part of the latter, external but not extraneous to it. The zona pellucida first appears in multilaminar primary oocytes.	GAID:410|EMAPA:16035|NCIT:C33896|FMA:18674|ZFA:0001111|TAO:0001111|EHDAA:31|UMLS:C0043519|EHDAA2:0002220|VHOG:0000720|EHDAA:62|MA:0001715|MESH:D015044|BTO:0003135|Wikipedia:Zona_pellucida	hp.json	vitelline envelope|zona radiata|pellucid zone|zona striata|striated membrane|vitelline membrane|oolemma|zona pellucida - vitelline membrane	http://purl.obolibrary.org/obo/UBERON_0000086		vertebrate_core|pheno_slim|human_reference_atlas
UBERON:0000087	biolink:AnatomicalEntity	inner cell mass	A mass of cells that develop into the body of the embryo and some extraembryonic tissues.	UMLS:C1283994|EHDAA2:0000830|EFO:0000547|FMA:86557|NCIT:C13740|EMAPA:16041|Wikipedia:Inner_cell_mass|EHDAA:40|SCTID:361456007|VHOG:0000742	hp.json	embryoblastus; massa cellularis interna; pluriblastus senior|ICM|embryoblastus; massa cellularis interna; pluriblastus senior|embryoblast|pluriblast|early embryoblast	http://purl.obolibrary.org/obo/UBERON_0000087		pheno_slim|early_development|efo_slim
UBERON:0000088	biolink:AnatomicalEntity	trophoblast	The mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta.	Wikipedia:Trophoblast|UMLS:C0041178|MESH:D014327|FMA:83029|SCTID:362839005|NCIT:C93292|CALOHA:TS-1070|EV:0100120|BTO:0001079|GAID:1152	hp.json	trophoblastus|massa cellularis externa|trophoderm|massa cellularis externa|trophoblastus|trophoblast layer	http://purl.obolibrary.org/obo/UBERON_0000088		pheno_slim|early_development
UBERON:0012054	biolink:AnatomicalEntity	myocoele	The cavity within a myotome.	VHOG:0001283|EMAPA:31134	hp.json		http://purl.obolibrary.org/obo/UBERON_0012054		
UBERON:0000071	biolink:AnatomicalEntity	death stage	End of the life of an organism.	XtroDO:0000085|XAO:0000437	hp.json	death	http://purl.obolibrary.org/obo/UBERON_0000071		
UBERON:0000072	biolink:AnatomicalEntity	proximo-distal subdivision of respiratory tract	An section of a respiratory tract.	FMA:45660|MA:0000434|EMAPA:16737	hp.json	respiratory tract|subdivision of respiratory tract	http://purl.obolibrary.org/obo/UBERON_0000072		non_informative
UBERON:0000073	biolink:AnatomicalEntity	regional part of nervous system	Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS.	UMLS:C1518256|SCTID:25087005|NCIT:C13040|BIRNLEX:1157	hp.json	part of nervous system	http://purl.obolibrary.org/obo/UBERON_0000073		non_informative|upper_level
UBERON:0000074	biolink:AnatomicalEntity	renal glomerulus	A capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney[GO].	ZFA:0001288|TAO:0001288|EFO:0003667|MESH:D007678|EV:0100386|BTO:0000530|EMAPA:28329|FMA:15624|UMLS:C0022663|CALOHA:TS-0862|NCIT:C13250|MA:0001657	hp.json	renal glomeruli|renal corpuscle|Malpighian tuft|glomerular tuft|glomerulus|Malphigian glomerulus|glomerular capillary tuft|glomerulus renis|Malpighian glomerulus	http://purl.obolibrary.org/obo/UBERON_0000074		vertebrate_core|pheno_slim|efo_slim
GO:0097708	biolink:CellularComponent	intracellular vesicle	Any vesicle that is part of the intracellular region.		hp.json		http://purl.obolibrary.org/obo/GO_0097708		
UBERON:0000079	biolink:AnatomicalEntity	male reproductive system	The organs associated with producing offspring in the gender that produces spermatozoa.	CALOHA:TS-1310|MESH:D005837|BTO:0000082|NCIT:C12722|XAO:0000155|GAID:386|UMLS:C1963704|MA:0000396|VHOG:0000725|EV:0100101|UMLS:C0017422|OpenCyc:Mx4rvViCepwpEbGdrcN5Y29ycA|HAO:0000505|FBbt:00004927|EFO:0000970|EHDAA:8136|EMAPA:17968|EHDAA2:0001054|TGMA:0000634|FMA:45664	hp.json	male genital tract|male genitals|genitalia of male organism|male genital system|male genitalia|systema genitale masculinum|reproductive system of male organism|male organism reproductive system|male reproductive tract|male organism genitalia|male genital organ	http://purl.obolibrary.org/obo/UBERON_0000079		pheno_slim|efo_slim
UBERON:0000075	biolink:AnatomicalEntity	subdivision of skeletal system	Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism.	UMLS:C1519343|galen:ComplexSkeletalStructure|FMA:85544|NCIT:C34076|SCTID:118966000	hp.json	skeletal system subdivision|skeletal system part	http://purl.obolibrary.org/obo/UBERON_0000075		non_informative
UBERON:0000076	biolink:AnatomicalEntity	external ectoderm	The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.	EHDAA:4796|FMA:87656|EMAPA:16096|EHDAA:4784|EHDAA:1494|Wikipedia:External_ectoderm|EHDAA:350|UMLS:C1515087|EHDAA:7860|EHDAA:4790|NCIT:C34309|EHDAA2:0001968	hp.json	surface ectoderm|surface (external) ectoderm	http://purl.obolibrary.org/obo/UBERON_0000076		pheno_slim
UBERON:0000077	biolink:AnatomicalEntity	mixed endoderm/mesoderm-derived structure	An anatomical structure that develops from the endoderm and the mesoderm.		hp.json		http://purl.obolibrary.org/obo/UBERON_0000077		grouping_class
UBERON:0000078	biolink:AnatomicalEntity	mixed ectoderm/mesoderm/endoderm-derived structure	An anatomical structure that develops from the ectoderm, mesoderm and endoderm.		hp.json		http://purl.obolibrary.org/obo/UBERON_0000078		grouping_class
OBO:uberon/core#synapsed_by	biolink:NamedThing	synapsed by	Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it.		hp.json		http://purl.obolibrary.org/obo/uberon/core#synapsed_by		
CHEBI:23390	biolink:ChemicalSubstance	cobalt-corrinoid hexaamide			hp.json		http://purl.obolibrary.org/obo/CHEBI_23390		1_STAR
UBERON:0000102	biolink:AnatomicalEntity	lung vasculature	The lung vasculature is composed of the tubule structures that carry blood or lymph in the lungs[GO].	FMA:73750	hp.json	pulmonary vasculature|lung vascular network|vasculature of lung|vascular network of lung	http://purl.obolibrary.org/obo/UBERON_0000102		pheno_slim
UBERON:0000104	biolink:AnatomicalEntity	life cycle	An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism.	ncithesaurus:Life|FBdv:00000000|MmusDv:0000001|OGES:000011|HsapDv:0000001	hp.json	entire life cycle|life|lifespan|entire lifespan	http://purl.obolibrary.org/obo/UBERON_0000104		upper_level
UBERON:0002749	biolink:AnatomicalEntity	regional part of cerebellar cortex	A regional part of brain that is part of a cerebellar cortex [Automatically generated definition].	BIRNLEX:1571|FMA:76924	hp.json	cerebellar cortical segment|segment of cerebellar cortex	http://purl.obolibrary.org/obo/UBERON_0002749		non_informative
GO:0009306	biolink:BiologicalProcess	protein secretion	The controlled release of proteins from a cell.		hp.json	protein secretion resulting in cell fate commitment|protein secretion during cell fate commitment|glycoprotein secretion	http://purl.obolibrary.org/obo/GO_0009306		
GO:0009308	biolink:BiologicalProcess	amine metabolic process	The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.		hp.json	amine metabolism	http://purl.obolibrary.org/obo/GO_0009308		goslim_pir|goslim_chembl
CHEBI:35381	biolink:ChemicalSubstance	monosaccharide	Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group.	KEGG:C06698	hp.json	monosaccharides|Monosaccharid|monosacaridos|Monosacharid|monosacarido|Monosaccharide	http://purl.obolibrary.org/obo/CHEBI_35381		3_STAR
GO:0009309	biolink:BiologicalProcess	amine biosynthetic process	The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.		hp.json	amine anabolism|amine synthesis|amine biosynthesis|amine formation	http://purl.obolibrary.org/obo/GO_0009309		
CHEBI:50996	biolink:ChemicalSubstance	tertiary amino compound	A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.		hp.json	tertiary amino compounds	http://purl.obolibrary.org/obo/CHEBI_50996		3_STAR
CHEBI:50994	biolink:ChemicalSubstance	primary amino compound	A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.		hp.json	primary amino compounds	http://purl.obolibrary.org/obo/CHEBI_50994		3_STAR
PATO:0000389	biolink:NamedThing	acute	A quality of a process inhering in a bearer by virtue of the bearer's having a sudden onset, sharp rise, and short course.		hp.json		http://purl.obolibrary.org/obo/PATO_0000389		hpo_slim|value_slim|mpath_slim
UBERON:0014720	biolink:AnatomicalEntity	interlobar duct	A duct that is located between lobes, within conspicuous, thick connective tissue septa that separate lobes. All interlobar ducts are excretory.		hp.json	intralobular ductule	http://purl.obolibrary.org/obo/UBERON_0014720		
PATO:0000381	biolink:NamedThing	decreased frequency	A frequency which is relatively low.		hp.json	infrequent|low frequency	http://purl.obolibrary.org/obo/PATO_0000381		value_slim|mpath_slim
UBERON:0014717	biolink:AnatomicalEntity	mucous acinus	The secretory unit of a mucous gland. The acinar portion is composed of mucous secreting cells.	FMA:86278	hp.json	acinus of mucuous gland|mucus acinus	http://purl.obolibrary.org/obo/UBERON_0014717		
PATO:0000380	biolink:NamedThing	increased frequency	A frequency which is relatively high.		hp.json	high frequency|frequent	http://purl.obolibrary.org/obo/PATO_0000380		value_slim|mpath_slim
UBERON:0014719	biolink:AnatomicalEntity	intralobular duct	A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular.		hp.json	intralobular ductule	http://purl.obolibrary.org/obo/UBERON_0014719		human_reference_atlas
PR:Q9QUM4	biolink:Protein	signaling lymphocytic activation molecule (mouse)	A SLAM family member 1 that is encoded in the genome of mouse.	UniProtKB:Q9QUM4	hp.json	Slam|Slamf1|mSLAMF1|SLAM family member 1 (mouse)|CD150 (mouse)	http://purl.obolibrary.org/obo/PR_Q9QUM4		
PATO:0000387	biolink:NamedThing	soft	A hardness quality of giving little resistance to pressure.		hp.json		http://purl.obolibrary.org/obo/PATO_0000387		disposition_slim|value_slim|mpath_slim
GO:0061900	biolink:BiologicalProcess	glial cell activation	A change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.		hp.json		http://purl.obolibrary.org/obo/GO_0061900		
UBERON:0014716	biolink:AnatomicalEntity	interlobular duct	A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory.	NCIT:C32828	hp.json		http://purl.obolibrary.org/obo/UBERON_0014716		human_reference_atlas
PATO:0000386	biolink:NamedThing	hard	A hardness quality of being rigid and resistant to pressure.		hp.json	firm|tough|impenetrable	http://purl.obolibrary.org/obo/PATO_0000386		disposition_slim|value_slim|mpath_slim
UBERON:0002742	biolink:AnatomicalEntity	lamina of septum pellucidum	One of two layers of both white and gray matter of the septum pellucidum. During fetal development there is a space between the two laminae called the cavum septum pellucidum which, in ninety per cent of cases, disappears during infancy.	FMA:62472|BIRNLEX:1554|UMLS:C0152278|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=258|BAMS:lsp	hp.json	lamina septi pellucidi|lamina of the septum pellucidum|septum pellucidum lamina|laminae septi pellucidi	http://purl.obolibrary.org/obo/UBERON_0002742		pheno_slim
UBERON:0002743	biolink:AnatomicalEntity	basal forebrain	A region of the brain consisting of ventral and rostral subcortical regions of the telencephalon, including among others, the basal ganglia, septal nuclei, amygdala, ventral pallidum, substantia innominata, and basal nucleus of Meynert.	PBA:128012976|HBA:4300|DHBA:10349|EMAPA:35164|BIRNLEX:1560|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1997|MESH:D066187|FMA:77700|BTO:0002444|BAMS:Basal_forebrain|BM:Tel-BF	hp.json	basal forebrain area|pars basalis telencephali	http://purl.obolibrary.org/obo/UBERON_0002743		uberon_slim|human_reference_atlas
CHEBI:59326	biolink:ChemicalSubstance	prostaglandin carboxylic acid anion	A prostanoid anion obtained by deprotonation of the carboxy group of any prostaglandin.		hp.json	prostaglandin carboxylic acid anions	http://purl.obolibrary.org/obo/CHEBI_59326		3_STAR
CHEBI:35350	biolink:ChemicalSubstance	hydroxy steroid		KEGG:C02159	hp.json	hydroxysteroids|hydroxy steroids|Hydroxysteroid	http://purl.obolibrary.org/obo/CHEBI_35350		3_STAR
CHEBI:35352	biolink:ChemicalSubstance	organonitrogen compound	Any heteroorganic entity containing at least one carbon-nitrogen bond.		hp.json	organonitrogens|organonitrogen compounds	http://purl.obolibrary.org/obo/CHEBI_35352		3_STAR
UBERON:0002726	biolink:AnatomicalEntity	cervical spinal cord	A spinal cord segment that adjacent_to a cervical region.	UMLS:C0581619|UMLS:C0581619|FMA:71166|NCIT:C12892|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1654|BIRNLEX:1499|UMLS:C1278837|MA:0003081|SCTID:180960003	hp.json	cervical segments of spinal cord [1-8]|cervical spinal cord|cervical segment of spinal cord|segmenta cervicalia medullae spinalis [1-8|pars cervicalis medullae spinalis	http://purl.obolibrary.org/obo/UBERON_0002726		
GO:0048934	biolink:BiologicalProcess	peripheral nervous system neuron differentiation	The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0048934		
PR:Q9QUM0	biolink:Protein	integrin alpha-IIb (mouse)	An integrin alpha-IIb that is encoded in the genome of mouse.	UniProtKB:Q9QUM0	hp.json	mITGA2B|CD41 (mouse)|Itga2b|GPIIb (mouse)|platelet membrane glycoprotein IIb (mouse)|GPalpha IIb (mouse)	http://purl.obolibrary.org/obo/PR_Q9QUM0		
CHEBI:35366	biolink:ChemicalSubstance	fatty acid	Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids.	KEGG:C00162|PMID:14328676|PMID:14300208|Wikipedia:Fatty_acid|PMID:14287444	hp.json	Fatty acid|acides gras|fatty acids|acide gras|acido graso|fatty acids|Fettsaeure|acidos grasos|Fettsaeuren	http://purl.obolibrary.org/obo/CHEBI_35366		3_STAR
UBERON:0014706	biolink:AnatomicalEntity	primitive renal collecting duct system		EHDAA2:0001147|EMAPA:17646	hp.json	metanephros primitive collecting ducts|primitive collecting duct	http://purl.obolibrary.org/obo/UBERON_0014706		
PATO:0000394	biolink:NamedThing	mild intensity	An intensity which is less than moderate in type or degree or effect or force.		hp.json		http://purl.obolibrary.org/obo/PATO_0000394		value_slim|mpath_slim|hpo_slim
PATO:0000396	biolink:NamedThing	severe intensity	An intensity which is extremely bad or unpleasant in type or degree or effect or force.		hp.json		http://purl.obolibrary.org/obo/PATO_0000396		value_slim|mpath_slim|hpo_slim
UBERON:0014702	biolink:AnatomicalEntity	frontonasal process epithelium	An epithelium that is part of a frontonasal prominence.	EMAPA:32918|EHDAA2:0004108	hp.json		http://purl.obolibrary.org/obo/UBERON_0014702		
PATO:0000395	biolink:NamedThing	moderate intensity	An intensity which is less than extreme in type or degree or effect or force.		hp.json		http://purl.obolibrary.org/obo/PATO_0000395		value_slim|mpath_slim|hpo_slim
UBERON:0014703	biolink:AnatomicalEntity	anal membrane ectodermal component	A unilaminar epithelium that develops_from a ectoderm and is part of a anal region.	EHDAA2:0004019|EMAPA:25040	hp.json		http://purl.obolibrary.org/obo/UBERON_0014703		
UBERON:0014704	biolink:AnatomicalEntity	pleuroperitoneal canal lumen	An anatomical space that is enclosed by a pleuroperitoneal canal.	EMAPA:25034|EHDAA2:0004736	hp.json	pleuro-peritoneal canal cavity	http://purl.obolibrary.org/obo/UBERON_0014704		
UBERON:0014705	biolink:AnatomicalEntity	median lingual swelling epithelium	An epithelium that is part of a median lingual swelling.	EHDAA2:0001085|EMAPA:17188	hp.json	tuberculum impar epitheilium	http://purl.obolibrary.org/obo/UBERON_0014705		
GO:0048935	biolink:BiologicalProcess	peripheral nervous system neuron development	The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.		hp.json		http://purl.obolibrary.org/obo/GO_0048935		
UBERON:0014780	biolink:AnatomicalEntity	palatine aponeurosis	Attached to the posterior border of the hard palate is a thin, firm fibrous lamella called the palatine aponeurosis, which supports the muscles and gives strength to the soft palate. It is thicker above than below, where it becomes very thin and difficult to define. Laterally it is continuous with the pharyngeal aponeurosis. It serves as the insertion for the Tensor veli palatini and Levator veli palatini, and the origin for the Musculus uvulae, Palatopharyngeus, and Palatoglossus. It provides support for the soft palate.	FMA:49429	hp.json	aponeurosis palatina|aponeurosis of tensor veli palatini	http://purl.obolibrary.org/obo/UBERON_0014780		
CHEBI:23354	biolink:ChemicalSubstance	coenzyme	A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons.		hp.json	coenzyme|coenzymes	http://purl.obolibrary.org/obo/CHEBI_23354		3_STAR
CHEBI:23357	biolink:ChemicalSubstance	cofactor	An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group).	Wikipedia:Cofactor_(biochemistry)	hp.json	cofactors|cofactor	http://purl.obolibrary.org/obo/CHEBI_23357		3_STAR
HP:0031463	biolink:PhenotypicFeature	Esophageal squamous papilloma	A rare benign epithelial tumor that is usually asymptomatic but can present with pyrosis and epigastric discomfort with or without dysphagia. Histopathologically, esophageal squamous papilloma has fingerlike projections lined with acanthotic stratified squamous epithelium with conservation of normal cellular with or without cellular atypia.		hp.json		http://purl.obolibrary.org/obo/HP_0031463		
PATO:0000323	biolink:NamedThing	white	An achromatic color of maximum brightness; the color of objects that reflect nearly all light of all visible wavelengths.		hp.json	whitish	http://purl.obolibrary.org/obo/PATO_0000323		value_slim|mpath_slim
HP:0031464	biolink:PhenotypicFeature	Genital blistering	The presence of one or more bullae on the skin of the genital region, defined as fluid-filled blisters more than 5 mm in diameter with thin walls.		hp.json		http://purl.obolibrary.org/obo/HP_0031464		
PATO:0000322	biolink:NamedThing	red	A color hue with high wavelength of the long-wave end of the visible spectrum, evoked in the human observer by radiant energy with wavelengths of approximately 630 to 750 nanometers.		hp.json		http://purl.obolibrary.org/obo/PATO_0000322		value_slim|mpath_slim
HP:0031465	biolink:PhenotypicFeature	Abnormal vasa vasorum morphology	A structural anomaly of vasa vasorum, which are defined as small blood vessels that supply or drain the walls of larger arteries and veins, delivering nutrients and oxygen as well as removing systemic waste products.		hp.json		http://purl.obolibrary.org/obo/HP_0031465		
HP:0031466	biolink:PhenotypicFeature	Impairment in personality functioning	A maladaptive personality trait characterized by moderate or greater impairment in personality (self /interpersonal) functioning.		hp.json		http://purl.obolibrary.org/obo/HP_0031466		
UBERON:0012126	biolink:AnatomicalEntity	fibulare	One of two elements that constitute the basal row of tarsals. The fibulare constitutes the preaxial element[AAO].	AAO:0000913	hp.json	astragalus	http://purl.obolibrary.org/obo/UBERON_0012126		
UBERON:0014783	biolink:AnatomicalEntity	cloacal muscle	Any muscle organ that is part of a cloaca.		hp.json		http://purl.obolibrary.org/obo/UBERON_0014783		
HP:0031460	biolink:PhenotypicFeature	Benign muscle neoplasm	A benign mesenchymal neoplasm arising from smooth, skeletal, or cardiac muscle tissue [NCIT:C4882].		hp.json		http://purl.obolibrary.org/obo/HP_0031460		
HP:0031461	biolink:PhenotypicFeature	Intramuscular Myxoma	A benign tumor that is usually solitary, painless, palpable mass that is firm in consistency and slightly movable and often fluctuant. It can occur in any location, but tends to involve the muscles of the thighs, buttocks, and shoulders. On microscopic examination, there is abundant mucoid material and relative hypo cellularity and loose reticulin fibers. Vascular structures are sparse. The cells have a stellate shape with small hyper chromatic pyknotic nuclei and scanty cytoplasm. Some myxomas may show focal areas of hyper cellularity. However absence of nuclear atypia, mitotic figures or necrosis helps to rule out malignancy.		hp.json	IM Myxoma	http://purl.obolibrary.org/obo/HP_0031461		
UBERON:0012125	biolink:AnatomicalEntity	dermatological-muscosal system	Anatomical system that consists of the integumental system plus all mucosae and submucosae.		hp.json	dermatological system	http://purl.obolibrary.org/obo/UBERON_0012125		
HP:0031462	biolink:PhenotypicFeature	Musculotendinous retraction	Abnormal reduction in length of a tendon which tends to pull (retract) the attached muscle tissue with shortening of the muscle fibers often accompanied by atrophy and fatty degeneration of the affected muscle tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0031462		
PATO:0000328	biolink:NamedThing	low saturation	A color saturation which is of low purity.		hp.json	dull|pale	http://purl.obolibrary.org/obo/PATO_0000328		value_slim
HP:0031467	biolink:PhenotypicFeature	Negative affectivity	A stable tendency to experience negative emotions, i.e., a disposition to experience aversive emotional states.		hp.json		http://purl.obolibrary.org/obo/HP_0031467		
HP:0031468	biolink:PhenotypicFeature	Separation insecurity	Fears of rejection by and/or separation from significant others, associated with fears of excessive dependency and complete loss of autonomy.		hp.json		http://purl.obolibrary.org/obo/HP_0031468		
HP:0031469	biolink:PhenotypicFeature	Low self esteem	Negative opinion about oneself characterized by low self-confidence and exaggeratedly critical feelings about oneself.		hp.json		http://purl.obolibrary.org/obo/HP_0031469		
PATO:0000320	biolink:NamedThing	green	A color hue with medium-low wavelength of that portion of the visible spectrum lying between yellow and blue, evoked in the human observer by radiant energy with wavelengths of approximately 490 to 570 nanometers.		hp.json		http://purl.obolibrary.org/obo/PATO_0000320		value_slim|mpath_slim
CHEBI:23366	biolink:ChemicalSubstance	compatible osmolytes			hp.json		http://purl.obolibrary.org/obo/CHEBI_23366		1_STAR
CHEBI:23367	biolink:ChemicalSubstance	molecular entity	Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.		hp.json	molekulare Entitaet|entite moleculaire|entidad molecular|entidades moleculares|molecular entity|molecular entities	http://purl.obolibrary.org/obo/CHEBI_23367		3_STAR
UBERON:0014770	biolink:AnatomicalEntity	palpebral artery	An artery that supplies blood to an eyelid.		hp.json		http://purl.obolibrary.org/obo/UBERON_0014770		
UBERON:0000127	biolink:AnatomicalEntity	facial nucleus	The group of motor neurons residing in the pons that innervate the muscles of facial expression.	EHDAA2:0004638|NCIT:C12898|BAMS:7N|MA:0001014|BM:Pons-VII|DHBA:12420|EV:0100267|MESH:D065828|EMAPA:35338|UMLS:C0228740|VHOG:0001412|BAMS:7|FMA:54572|BAMS:VII	hp.json	facial VII motor nucleus|facial VII nucleus|facial nerve nucleus|nucleus of facial nerve	http://purl.obolibrary.org/obo/UBERON_0000127		pheno_slim
CHEBI:50967	biolink:ChemicalSubstance	non-covalently-bound molecular entity	Systems consisting of two or more molecular entities held together by non-covalent interactions.		hp.json	non-covalently-bound molecular entities	http://purl.obolibrary.org/obo/CHEBI_50967		3_STAR
UBERON:0000128	biolink:AnatomicalEntity	olivary body	Prominent oval structure in the medulla oblongata, present in pairs, the lower portion of the brainstem. They contain the olivary nuclei.	BTO:0002299	hp.json	olivary nucleus|olive body|oliva|olive	http://purl.obolibrary.org/obo/UBERON_0000128		pheno_slim
UBERON:0014775	biolink:AnatomicalEntity	prosomere	A neuromere that is part of the presumptive forebrain.	FMA:61996	hp.json	future prosencephalon|segment of forebrain|forebrain segment|forebrain neuromere	http://purl.obolibrary.org/obo/UBERON_0014775		
HP:0031474	biolink:PhenotypicFeature	Pulmonary chondroma	A benign cartilaginous tumors of the lung.		hp.json		http://purl.obolibrary.org/obo/HP_0031474		
UBERON:0012111	biolink:AnatomicalEntity	diastema	A space or gap between two consecutive teeth.	FMA:77271|MESH:D003970	hp.json	diastemata|interdental space	http://purl.obolibrary.org/obo/UBERON_0012111		
UBERON:0014776	biolink:AnatomicalEntity	midbrain neuromere	A neuromere that is part of the presumptive midbrain.	FMA:61997|EHDAA2:0004352	hp.json	neuromere of mesomere group|mesomere group|future mesencephalon|midbrain segment|mesomere of nervous system|mesomere|segment of midbrain	http://purl.obolibrary.org/obo/UBERON_0014776		
HP:0031475	biolink:PhenotypicFeature	Status epilepticus without prominent motor symptoms	There is inconclusive evidence to precisely define the duration of the seizure; however, based on current evidence an operational threshold of 10 minutes is appropriate as beyond this a seizure is likely to be more prolonged. The individual may or may not be aware or in coma.		hp.json	Nonconvulsive status epilepticus	http://purl.obolibrary.org/obo/HP_0031475		
HP:0031476	biolink:PhenotypicFeature	Abnormal buccal mucosa cell morphology	Any structural anomaly of the cells of the mucosa of the oral cavity in the region of the cheek (buccal mucosa cells).		hp.json		http://purl.obolibrary.org/obo/HP_0031476		
UBERON:0014777	biolink:AnatomicalEntity	spinal neuromere	A neuromere that is part of the presumptive spinal cord.	ZFA:0001332|TAO:0001332	hp.json	spinal neuromeres|spinal cord segment|spinal cord metameric segment	http://purl.obolibrary.org/obo/UBERON_0014777		
HP:0031477	biolink:PhenotypicFeature	obsolete Abnormal mitral valve morphology			hp.json		http://purl.obolibrary.org/obo/HP_0031477		
OBO:MAXO_0001181	biolink:NamedThing	serum alkaline phosphatase measurement	The determination of the amount of alkaline phosphatase present in blood serum.		hp.json	blood serum alkaline phosphatase test|serum Alk phos measurement|alkaline phosphatase blood serum assessment	http://purl.obolibrary.org/obo/MAXO_0001181		
HP:0031472	biolink:PhenotypicFeature	Risk taking	Engagement in dangerous, risky, and potentially self-damaging activities, unnecessarily and without regard to consequences; lack of concern for one's limitations and denial of the reality of personal danger.		hp.json		http://purl.obolibrary.org/obo/HP_0031472		
HP:0031473	biolink:PhenotypicFeature	Hostility	Persistent or frequent angry feelings; anger or irritability in response to minor slights and insults.		hp.json		http://purl.obolibrary.org/obo/HP_0031473		
CHEBI:35344	biolink:ChemicalSubstance	21-hydroxy steroid		KEGG:C02506	hp.json	21-hydroxysteroids|21-hydroxy steroids|21-Hydroxysteroid	http://purl.obolibrary.org/obo/CHEBI_35344		3_STAR
CHEBI:35343	biolink:ChemicalSubstance	17beta-hydroxy steroid	A 17-hydroxy steroid in which the hydroxy group at position 17 has a beta-configuration.	MetaCyc:17-beta-Hydroxysteroids|KEGG:C03051	hp.json	17beta-hydroxy steroids|17beta-hydroxysteroid|a 17beta-hydroxy steroid|17beta-hydroxysteroids	http://purl.obolibrary.org/obo/CHEBI_35343		3_STAR
CHEBI:35346	biolink:ChemicalSubstance	11beta-hydroxy steroid	Any 11-hydroxy steroid in which the hydroxy group at position 11 has beta- configuration.	KEGG:C01058	hp.json	11beta-Hydroxysteroid|11beta-hydroxysteroids|an 11beta-hydroxysteroid|11beta-hydroxy steroids	http://purl.obolibrary.org/obo/CHEBI_35346		3_STAR
CHEBI:35348	biolink:ChemicalSubstance	3beta-sterol	A sterol in which the hydroxy group at position 3 has beta- configuration.		hp.json	3beta-sterols|3beta-hydroxysteroids	http://purl.obolibrary.org/obo/CHEBI_35348		3_STAR
HP:0031478	biolink:PhenotypicFeature	Abnormal mitral valve annulus morphology	Any structural anomaly of the annulus of the mitral valve. The annulus is a ring composed of fibrous and myocardial tissue and is the structure onto which the cusps of the valve attach.		hp.json		http://purl.obolibrary.org/obo/HP_0031478		
PATO:0000330	biolink:NamedThing	irregular spatial pattern	A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency.		hp.json		http://purl.obolibrary.org/obo/PATO_0000330		mpath_slim|cell_quality|value_slim
UBERON:0014768	biolink:AnatomicalEntity	superior palpebral vein	A blood vessel that drains from from an upper eyelid.	FMA:50907	hp.json	venae palpebrales superiores	http://purl.obolibrary.org/obo/UBERON_0014768		human_reference_atlas
HP:0031479	biolink:PhenotypicFeature	Dilatation of the mitral annulus	An increase in the diameter of the ring (annulus) of the mitral valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031479		
UBERON:0014769	biolink:AnatomicalEntity	palpebral vein	A blood vessel that drains from from an eyelid.	FMA:51997	hp.json	palpebral veins|venae palpebrales	http://purl.obolibrary.org/obo/UBERON_0014769		
UBERON:0002792	biolink:AnatomicalEntity	lumbar spinal cord		FMA:71168|BIRNLEX:1704|UMLS:C0581620|MA:0003083|UMLS:C1278838|UMLS:C0581621|NCIT:C12895	hp.json	segmenta lumbalia medullae spinalis [1-5]|pars lumbalis medullae spinalis|lumbar spinal cord|spinal cord lumbar segment|lumbar segment of spinal cord|lumbar segments of spinal cord [1-5]	http://purl.obolibrary.org/obo/UBERON_0002792		uberon_slim
CHEBI:35342	biolink:ChemicalSubstance	17alpha-hydroxy steroid	The alpha-stereoisomer of 17-hydroxy steroid.	KEGG:C03336	hp.json	17alpha-hydroxy steroids|17-alpha-Hydroxysteroid	http://purl.obolibrary.org/obo/CHEBI_35342		3_STAR
CHEBI:35341	biolink:ChemicalSubstance	steroid	Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.	KEGG:C00377|MetaCyc:Steroids	hp.json	steroids|Steroid|a steroid	http://purl.obolibrary.org/obo/CHEBI_35341		3_STAR
CHEBI:23333	biolink:ChemicalSubstance	cob(III)alamins			hp.json		http://purl.obolibrary.org/obo/CHEBI_23333		3_STAR
CHEBI:23334	biolink:ChemicalSubstance	cobalamins			hp.json		http://purl.obolibrary.org/obo/CHEBI_23334		3_STAR
HP:0031480	biolink:PhenotypicFeature	Abnormal mitral valve leaflet morphology	Any structural anomaly of the leaflets (also known as cusps) of the mitral valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031480		
UBERON:0000117	biolink:AnatomicalEntity	respiratory tube	A tube in the respiratory system. Examples: bronchus, bronchiole, trachea.	EMAPA:37946|FMA:12224	hp.json	segment of tracheobronchial tree|airway|segment of tracheobronchial tree|tracheobronchial tree segment|respiratory conducting tube	http://purl.obolibrary.org/obo/UBERON_0000117		
UBERON:0000118	biolink:AnatomicalEntity	lung bud	Structure derived from foregut that becomes a lung[GO].	NCIT:C34282|NCIT:C34260|SCTID:361427007|UMLS:C1514897|Wikipedia:Respiratory_bud|BTO:0001643|EHDAA2:0004089|UMLS:C1514420	hp.json	respiratory diverticulum|gemma pulmonalis|primary lung bud|gemma pulmonalis|gemma respiratoria|gemma respiratoria|respiratory diverticulum|lung bud	http://purl.obolibrary.org/obo/UBERON_0000118		pheno_slim
UBERON:0000119	biolink:AnatomicalEntity	cell layer	Portion of tissue, that consists of single layer of cells connected to each other by cell junctions. Examples: layer of glial cells; epithelium.	NCIT:C66831	hp.json	sheath of cells|cell sheath|layer|layer of cells	http://purl.obolibrary.org/obo/UBERON_0000119		upper_level
HP:0031485	biolink:PhenotypicFeature	Subperiosteal bone formation	The formation of new bone along the cortex and underneath the periosteum of a bone.		hp.json	Periosteal reaction	http://purl.obolibrary.org/obo/HP_0031485		
UBERON:0014765	biolink:AnatomicalEntity	crus of diaphragm	The domain of the diaphragm that is located dorsally and attaches to the vertebrae and surrounds the esophagus and aorta.	EHDAA2:0000597|VHOG:0001546|EMAPA:17703	hp.json	crus of the diaphragm|crural diaphragm|crura of the diaphragm|diaphragmatic crura|diaphragm crura	http://purl.obolibrary.org/obo/UBERON_0014765		
HP:0031486	biolink:PhenotypicFeature	Vascular malformation of the lip	An anomaly of blood vessels located in the lip.		hp.json		http://purl.obolibrary.org/obo/HP_0031486		
UBERON:0014766	biolink:AnatomicalEntity	right crus of diaphragm	A crus of diaphragm that is in_the_right_side_of a diaphragm.	FMA:58286	hp.json	external sphincter of esophagus|crus dextrum diaphragmatis|right crus of lumbar part of diaphragm|crus dextrum (Diaphragma)|right crus of diaphragm	http://purl.obolibrary.org/obo/UBERON_0014766		
HP:0031487	biolink:PhenotypicFeature	Capillary malformation of the lip	A vascular malformation located in the lip that is characterized by ectatic papillary dermal capillaries and postcapillary venules in the upper reticular dermis.		hp.json		http://purl.obolibrary.org/obo/HP_0031487		
UBERON:0014767	biolink:AnatomicalEntity	left crus of diaphragm	A crus of diaphragm that is in_the_left_side_of a diaphragm.	FMA:58287	hp.json	left crus of lumbar part of diaphragm|left crus of diaphragm|crus sinistrum (Diaphragma)|crus sinistrum diaphragmatis	http://purl.obolibrary.org/obo/UBERON_0014767		
HP:0031488	biolink:PhenotypicFeature	Arteriovenous malformation of the lip	A vascular malformation located in the lip that is characterized by direct blood shunting from an artery to a vein due to the absence of a capillary bed. The artery and vein can be directly connected by a fistula or indirectly connected by an abnormal vessel channel termed a nidus.		hp.json	Atypical connection between arteries and veins	http://purl.obolibrary.org/obo/HP_0031488		
HP:0031481	biolink:PhenotypicFeature	Abnormal mitral valve physiology	Any functional anomaly of the mitral valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031481		
HP:0031482	biolink:PhenotypicFeature	Abnormal regional left ventricular contraction	A wall motion abnormality observed upon left ventricular contraction that affects a specific region of the left ventricle.		hp.json		http://purl.obolibrary.org/obo/HP_0031482		
UBERON:0014762	biolink:AnatomicalEntity	fused metapodial bones 2-4	An element formed from the fusion of metapodium bones 2, 3 and 4 (i.e. either metatarsals 2-4 or metacarpals 3-4).		hp.json	fused central metapodials|metapodial 2+3+4|fused metapodials 2-4	http://purl.obolibrary.org/obo/UBERON_0014762		
HP:0031483	biolink:PhenotypicFeature	Reduced contraction of the left ventricular apex	Reduced wall motion (contraction) of the apex of the left ventricle. This manifestation can be observed on echocardiography.		hp.json		http://purl.obolibrary.org/obo/HP_0031483		
UBERON:0012102	biolink:AnatomicalEntity	buccal salivary gland	A salivary gland that is part of a cheek.	NCIT:C32237|FMA:59793	hp.json		http://purl.obolibrary.org/obo/UBERON_0012102		
UBERON:0014763	biolink:AnatomicalEntity	fused metatarsal bones 2-4	An element formed from the fusion of metapodium bones 2, 3 and 4 in the pedal autopod.		hp.json	fused metatarsals 2-4|cannon bone|fused central metatarsals|metatarsal 2+3+4	http://purl.obolibrary.org/obo/UBERON_0014763		
HP:0031484	biolink:PhenotypicFeature	Cold-induced hemolysis	A form of hemolytic anemia that can be triggered by cold temperatures.		hp.json		http://purl.obolibrary.org/obo/HP_0031484		
PR:000011649	biolink:Protein	5-oxoprolinase	A protein that is a translation product of the human OPLAH gene or a 1:1 ortholog thereof.		hp.json	5-OPase|OPLAH|5-oxo-L-prolinase|pyroglutamase	http://purl.obolibrary.org/obo/PR_000011649		
CHEBI:35313	biolink:ChemicalSubstance	hexoside			hp.json	hexoside|hexosides	http://purl.obolibrary.org/obo/CHEBI_35313		3_STAR
HP:0031489	biolink:PhenotypicFeature	Venous malformation of the lip	A vascular malformation located in the lip that is related to abnormal vascular morphogenesis.		hp.json		http://purl.obolibrary.org/obo/HP_0031489		
GO:0000902	biolink:BiologicalProcess	cell morphogenesis	The developmental process in which the size or shape of a cell is generated and organized.		hp.json	cellular morphogenesis	http://purl.obolibrary.org/obo/GO_0000902		goslim_yeast|goslim_drosophila|goslim_chembl
GO:0000904	biolink:BiologicalProcess	cell morphogenesis involved in differentiation	The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.		hp.json		http://purl.obolibrary.org/obo/GO_0000904		
UBERON:0000125	biolink:AnatomicalEntity	neural nucleus	A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO).	NLX:28443|FMA:83686|AEO:0000136|NCIT:C13197|Wikipedia:Nucleus_(neuroanatomy)	hp.json	nervous system nucleus|neuronal nucleus|nucleus of neuraxis|nucleus|neuraxis nucleus|nucleus of CNS	http://purl.obolibrary.org/obo/UBERON_0000125		cumbo
UBERON:0000126	biolink:AnatomicalEntity	cranial nerve nucleus	Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves.	NLX:28532|FMA:54501|SCTID:280160003|Wikipedia:Cranial_nerve_nucleus|EMAPA:37066	hp.json	nucleus nervi cranialis|nucleus nervi cranialis|nucleus of cranial nerve|cranial neural nucleus	http://purl.obolibrary.org/obo/UBERON_0000126		
UBERON:0002787	biolink:AnatomicalEntity	decussation of trochlear nerve	The crossing of the two trochlear nerves at their exit through the velum medullare anterius.	BIRNLEX:1690|BAMS:4x|FMA:72488|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=595|UMLS:C0175448|BAMS:IVd|MBA:384|DHBA:12338	hp.json	decussation of trochlear nerve (IV)|decussatio fibrarum nervorum trochlearium|trochlear neural decussation|decussation of trochlear nerve fibers|decussation of the trochlear nerve|trochlear decussation|trochlear nerve decussation|decussatio nervorum trochlearium|decussatio trochlearis	http://purl.obolibrary.org/obo/UBERON_0002787		
UBERON:0000122	biolink:AnatomicalEntity	neuron projection bundle	A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.	FBbt:00005099|NLX:147821|CARO:0001001	hp.json	funiculus|neural fiber bundle|nerve fiber bundle	http://purl.obolibrary.org/obo/UBERON_0000122		
UBERON:0000109	biolink:AnatomicalEntity	gastrula stage	A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.	XAO:1000005|EFO:0001296|HsapDv:0000010|FBdv:00005317|ZFS:0000047|BILS:0000109|OGES:000019|MmusDv:0000013|OGES:000004|WBls:0000010|BilaDO:0000008	hp.json	trilaminar stage|trilaminar germ stage|trilaminar blastoderm stage|blastocystis trilaminaris stage|trilaminar stage|trilaminar blastocyst stage|trilaminar blastoderm stage|trilaminar disk stage|trilaminar blastocyst stage|trilaminar germ stage|trilaminar disk stage|blastocystis trilaminaris stage	http://purl.obolibrary.org/obo/UBERON_0000109		efo_slim
HP:0031490	biolink:PhenotypicFeature	Hemangioma of the lip	A vascular malformation located in the lip that is related to vascular endothelial cell hyperplasia.		hp.json		http://purl.obolibrary.org/obo/HP_0031490		
HP:0031491	biolink:PhenotypicFeature	Continuous spike and waves during slow sleep	Diffuse, bilateral and recently also unilateral or focal localization spike-wave occurring in slow sleep or non-rapid eye movement sleep.		hp.json	CSWS|Electrical status epilepticus during slow-wave sleep	http://purl.obolibrary.org/obo/HP_0031491		
UBERON:0000105	biolink:AnatomicalEntity	life cycle stage	A spatiotemporal region encompassing some part of the life cycle of an organism.	HsapDv:0000000|ncithesaurus:Developmental_Stage|ZFS:0000000|FMA:24120|XAO:1000000|ZFS:0100000|PdumDv:0000090|WBls:0000002|BILS:0000105|OlatDv:0000010|EFO:0000399|MESH:D008018|MmusDv:0000000|FBdv:00007012	hp.json	stage|developmental stage	http://purl.obolibrary.org/obo/UBERON_0000105		upper_level|efo_slim
UBERON:0000106	biolink:AnatomicalEntity	zygote stage	A stage at which the organism is a single cell produced by means of sexual reproduction.	BilaDO:0000005|EHDAA:27|XAO:1000001|ZFS:0000001|NCIT:C12601|BILS:0000106|Wikipedia:Zygote|FBdv:00005288|VHOG:0000745|EFO:0001322|PdumDv:0000100	hp.json	fertilized egg stage|fertilized egg stage|zygotum|zygote|one-cell stage|1-cell stage|one cell stage|zygotum	http://purl.obolibrary.org/obo/UBERON_0000106		efo_slim
UBERON:0000107	biolink:AnatomicalEntity	cleavage stage	The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula.	BilaDO:0000006|OGES:000020|Wikipedia:Cleavage_(embryo)|XAO:1000004|ZFS:0000046|EFO:0001290|BILS:0000107|FBdv:00000054|MmusDv:0000004|MESH:A16.254.270|OGES:000015|MESH:D002970|PdumDv:0000200	hp.json		http://purl.obolibrary.org/obo/UBERON_0000107		efo_slim
UBERON:0000108	biolink:AnatomicalEntity	blastula stage	An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence.	OGES:000021|XAO:1000003|EFO:0001282|ZFS:0000045|MmusDv:0000007|WBls:0000005|BILS:0000108|OGES:000016|OpenCyc:Mx4rEetFnKP2EdqAAAACs4vPlg|HsapDv:0000006|OGES:000003|Wikipedia:Blastula|BilaDO:0000007	hp.json		http://purl.obolibrary.org/obo/UBERON_0000108		efo_slim
HP:0031496	biolink:PhenotypicFeature	Mucinous cystic neoplasm of the pancreas	Mucin-producing and septated cyst-forming epithelial neoplasia of the pancreas with a distinctive ovarian-type stroma.		hp.json		http://purl.obolibrary.org/obo/HP_0031496		
HP:0031497	biolink:PhenotypicFeature	Mucinous colorectal carcinoma	A subtype of colorectal carcinoma with mucin lakes.		hp.json		http://purl.obolibrary.org/obo/HP_0031497		
HP:0031498	biolink:PhenotypicFeature	Mucinous gastric carcinoma	A poorly differentiated type of gastric carcinoma with a substantial amount of extracellular mucus (over 50% of tumor volume) within the tumor.		hp.json		http://purl.obolibrary.org/obo/HP_0031498		
HP:0031499	biolink:PhenotypicFeature	Appendiceal mucinous neoplasm	An epithelial neoplasm originating in the appendix and often associated with cystic dilation of the appendix due to accumulation of gelatinous material, morphologically referred to as mucoceles.		hp.json		http://purl.obolibrary.org/obo/HP_0031499		
HP:0031492	biolink:PhenotypicFeature	Epithelial neoplasm	A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas [NCIT:C3709].		hp.json		http://purl.obolibrary.org/obo/HP_0031492		
CHEBI:23341	biolink:ChemicalSubstance	cobamides			hp.json		http://purl.obolibrary.org/obo/CHEBI_23341		1_STAR
HP:0031493	biolink:PhenotypicFeature	Glandular cell neoplasm	A tumor that arises from a gland cell.		hp.json		http://purl.obolibrary.org/obo/HP_0031493		
HP:0031494	biolink:PhenotypicFeature	Ovarian mucinous tumor	Ovarian mucinous neoplasms consist of borderline tumors (tumors of low malignant potential, or LMP tumors), intraepithelial (non-invasive) carcinoma, and invasive carcinoma.		hp.json	Ovarian mucinous tumour|Mucinous neoplasm of the ovary	http://purl.obolibrary.org/obo/HP_0031494		
HP:0031495	biolink:PhenotypicFeature	Mucinous neoplasm			hp.json		http://purl.obolibrary.org/obo/HP_0031495		
UBERON:0000112	biolink:AnatomicalEntity	sexually immature stage		OGES:000009|XAO:1000010|ZFS:0000051|BILS:0000112|EFO:0001300|XtroDO:0000083|MmusDv:0000043|BTO:0002168|EV:0300051	hp.json	immature stage|subadult stage|juvenile stage|subadult stage	http://purl.obolibrary.org/obo/UBERON_0000112		efo_slim
UBERON:0000113	biolink:AnatomicalEntity	post-juvenile adult stage	The stage of being a sexually mature adult animal.	ZFS:0000044|EV:0300070|OGES:000027|MIAA:0000403|OGES:000026|XAO:1000093|BILS:0000113|MmusDv:0000110|EV:0300064	hp.json	adult stage	http://purl.obolibrary.org/obo/UBERON_0000113		
UBERON:0000114	biolink:AnatomicalEntity	lung connective tissue	The connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin.	FMA:27533|MA:0001782|EMAPA:35521|SCTID:201609008	hp.json	lung interstitial tissue|pulmonary interstitium|pulmonary interstitial tissue|pulmonary connective tissue|connective tissue of lung|lung interstitium	http://purl.obolibrary.org/obo/UBERON_0000114		pheno_slim
UBERON:0000115	biolink:AnatomicalEntity	lung epithelium	The epithelial layer of the lung.	MA:0001783|BTO:0001653|EMAPA:32860	hp.json	lung epithelial tissue|pulmonary epithelium|epithelial tissue of lung|epithelium of lung	http://purl.obolibrary.org/obo/UBERON_0000115		pheno_slim
GO:0061938	biolink:BiologicalProcess	protein localization to somatodendritic compartment	A process in which a protein is transported to or maintained in a location within the somatodendritic compartment.		hp.json	somatodendritic protein localization	http://purl.obolibrary.org/obo/GO_0061938		
GO:1902809	biolink:BiologicalProcess	regulation of skeletal muscle fiber differentiation	Any process that modulates the frequency, rate or extent of skeletal muscle fiber differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_1902809		
UBERON:0000110	biolink:AnatomicalEntity	neurula stage	Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.	MmusDv:0000017|BilaDO:0000009|BILS:0000110|XAO:1000006|HsapDv:0000012	hp.json		http://purl.obolibrary.org/obo/UBERON_0000110		
UBERON:0000111	biolink:AnatomicalEntity	organogenesis stage	A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism.	MmusDv:0000018|BilaDO:0000010|OGES:000005|Wikipedia:Organogenesis|HsapDv:0000015|BILS:0000111|OGES:000032	hp.json	segmentation stage	http://purl.obolibrary.org/obo/UBERON_0000111		
OBO:MAXO_0001154	biolink:NamedThing	cervical examination	A systemic evaluation of the uterine cervix using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.		hp.json	examination of uterine cervix|physical examination of uterine cervix|examination of the cervix|uterine cervix exam	http://purl.obolibrary.org/obo/MAXO_0001154		
OBO:MAXO_0001153	biolink:NamedThing	uterus examination	A systemic evaluation of the uterus using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.		hp.json	physical examination of uterus|uterus exam|examination of uterus	http://purl.obolibrary.org/obo/MAXO_0001153		
OBO:MAXO_0001152	biolink:NamedThing	chest examination	A systemic evaluation of the chest using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.		hp.json	examination of chest|physical examination of chest|chest exam	http://purl.obolibrary.org/obo/MAXO_0001152		
OBO:MAXO_0001151	biolink:NamedThing	neck examination	A systemic evaluation of the neck using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.		hp.json	examination of neck|neck exam|physical examination of neck	http://purl.obolibrary.org/obo/MAXO_0001151		
OBO:MAXO_0001156	biolink:NamedThing	whole body examination	A systemic evaluation of the multicellular organism using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.		hp.json	examination of multicellular organism|examination of whole body|whole body exam|multicellular organism exam|physical examination of multicellular organism	http://purl.obolibrary.org/obo/MAXO_0001156		
OBO:MAXO_0001155	biolink:NamedThing	eye examination	A systemic evaluation of the eye using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.		hp.json	examination of eye|physical examination of eye|eye exam	http://purl.obolibrary.org/obo/MAXO_0001155		
HP:0031420	biolink:PhenotypicFeature	Small yellow foveal lesion with surrounding gray zone	A lesion that is observed following light damage to the macula. Damage to the retinal by exposure to intense visible light, usually the sun. Intense light exposure such as staring at the sun causes fine structural anomalies in the outer segments of the photoreceptors and the retinal pigment epithelium (RPE) cells of the macula. Symptoms usually develop within 1 to 4 h after exposure and include decreased vision, metamorphopsia, micropsia, and central or paracentral scotomas. Fundus examination typically shows a small yellow spot with a surrounding gray zone in the foveolar or parafoveolar area. Spontaneous evolution leads to the improvement of visual acuity.		hp.json	Small yellow foveal lesion with surrounding grey zone|Laser pointer-induced retinopathy|Photic retinopathy|Laser pointer-induced maculopathy|Light induced retinopathy|Solar retinopathy|Solar retinitis	http://purl.obolibrary.org/obo/HP_0031420		
HP:0031421	biolink:PhenotypicFeature	Small superior frontal cortex	Reduced size of the superior frontal portion of the cerebral cortex.		hp.json		http://purl.obolibrary.org/obo/HP_0031421		
HP:0031422	biolink:PhenotypicFeature	Abnormal cerebellar cortex morphology	Any structural anomaly of the cortex of the cerebellum.		hp.json	Abnormal morphology of the cerebellar cortex	http://purl.obolibrary.org/obo/HP_0031422		
OBO:MAXO_0001150	biolink:NamedThing	head examination	A systemic evaluation of the head using visual inspection, palpation, and percussion. The purpose is to determine the presence or absence of physical signs of disease or abnormality for an individual's health assessment.		hp.json	examination of head|physical examination of head|head exam	http://purl.obolibrary.org/obo/MAXO_0001150		
GO:0034330	biolink:BiologicalProcess	cell junction organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell junction. A cell junction is a specialized region of connection between two cells or between a cell and the extracellular matrix.		hp.json	cell junction biogenesis|cell junction organisation|cell junction assembly and maintenance	http://purl.obolibrary.org/obo/GO_0034330		goslim_chembl|goslim_generic
HP:0031427	biolink:PhenotypicFeature	Abnormal circulating osteocalcin level	A deviation from the normal concentration of osteocalcin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031427		
HP:0031428	biolink:PhenotypicFeature	Increased circulating osteocalcin level	An elevated level of osteocalcin in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031428		
HP:0031429	biolink:PhenotypicFeature	Decreased circulating osteocalcin level	A reduced level of osteocalcin in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031429		
HP:0031423	biolink:PhenotypicFeature	Small cerebellar cortex	Reduced size of the cerebellar cortex.		hp.json		http://purl.obolibrary.org/obo/HP_0031423		
HP:0006456	biolink:PhenotypicFeature	Irregular proximal tibial epiphyses	Anomaly of the contour of the proximal epiphysis of the tibia such that its normally smooth appearance is irregular.	UMLS:C4025045	hp.json	Irregular innermost shankbone end part|Irregular innermost shinbone end part	http://purl.obolibrary.org/obo/HP_0006456		
HP:0031424	biolink:PhenotypicFeature	Abnormal circulating beta-C-terminal telopeptide level	A deviation from the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation, a marker of the rate of bone turnover.		hp.json	Abnormal circulating beta-CrossLaps level|Abnormal circulating beta-CTx level	http://purl.obolibrary.org/obo/HP_0031424		
HP:0031425	biolink:PhenotypicFeature	Increased circulating beta-C-terminal telopeptide level	A abnormal elevation above the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation.		hp.json	Increased circulating beta-CrossLaps level|Increased circulating beta-CTx level	http://purl.obolibrary.org/obo/HP_0031425		
HP:0006459	biolink:PhenotypicFeature	Dorsal subluxation of ulna	Partial dislocation of the ulna in the dorsal direction.	UMLS:C1851988	hp.json		http://purl.obolibrary.org/obo/HP_0006459		
HP:0031426	biolink:PhenotypicFeature	Decreased circulating beta-C-terminal telopeptide level	A reduction from the normal concentration of beta-C-terminal telopeptide of type I collagen in the blood circulation.		hp.json	Decreased circulating beta-CrossLaps level|Decreased circulating beta-CTx level	http://purl.obolibrary.org/obo/HP_0031426		
HP:0006453	biolink:PhenotypicFeature	Lateral displacement of the femoral head	A developmental anomaly with lateral displacement of the femoral head.	UMLS:C1855758	hp.json	Laterally displaced femoral heads	http://purl.obolibrary.org/obo/HP_0006453		
HP:0006454	biolink:PhenotypicFeature	Delayed patellar ossification	Formation of bone in the patella later than normal.	UMLS:C4280446|UMLS:C4021597	hp.json	Delayed patellae ossification|Delayed bone maturation of the knee cap	http://purl.obolibrary.org/obo/HP_0006454		
OBO:MAXO_0001159	biolink:NamedThing	endocervical swab collection	Collection biological material from within the endocervix with a cotton swab.		hp.json	swab collection of endocervix|endocervical swab	http://purl.obolibrary.org/obo/MAXO_0001159		
HP:0006450	biolink:PhenotypicFeature	Multicentric ossification of proximal femoral epiphyses		UMLS:C1857193	hp.json		http://purl.obolibrary.org/obo/HP_0006450		
HP:0031430	biolink:PhenotypicFeature	Oligoclonal T cell expansion	The presence of a population of T cells with a restricted T cell receptor (TCR) repertoire derived from a limited number of TCR clones.		hp.json		http://purl.obolibrary.org/obo/HP_0031430		
HP:0031431	biolink:PhenotypicFeature	Persistent repetition of words	Repetitive use of words, phrases, intonation, or sounds of speech, often of the speech of others.		hp.json		http://purl.obolibrary.org/obo/HP_0031431		
GO:0034329	biolink:BiologicalProcess	cell junction assembly	A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.		hp.json		http://purl.obolibrary.org/obo/GO_0034329		
HP:0031432	biolink:PhenotypicFeature	Persistent repetition of actions	Repeated and inappropriate mechanical repetition of actions.		hp.json		http://purl.obolibrary.org/obo/HP_0031432		
HP:0031433	biolink:PhenotypicFeature	Alexithymia	A deficit in emotional awareness characterized by difficulties in recognizing and expressing feelings and emotions manifested as a limited ability to respond to facial clues or other signs of emotions in others often accompanied by detached connections to others.		hp.json	Unaware of others' emotions	http://purl.obolibrary.org/obo/HP_0031433		
HP:0031438	biolink:PhenotypicFeature	Abnormal sex hormone-binding globulin level	A deviation from the normal concentration in the circulation of sex hormone-binding globulin, a circulating glycoprotein that transports testosterone and other steroids in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031438		
HP:0031439	biolink:PhenotypicFeature	Abnormal angiostatin level	A deviation from the normal concentration in the circulation of angiostatin, an endogenous angiogenesis inhibitor, which blocks the growth of new blood vessels.		hp.json		http://purl.obolibrary.org/obo/HP_0031439		
HP:0031434	biolink:PhenotypicFeature	Abnormal speech prosody	An anomaly of the expressive patterns of speech that involve intonation, stress pattern, loudness variations, pausing, articulatory force, and rhythm.		hp.json		http://purl.obolibrary.org/obo/HP_0031434		
HP:0006467	biolink:PhenotypicFeature	Limited shoulder movement	A limitation of the range of movement of the shoulder joint.	UMLS:C1851313	hp.json	Limited shoulder movement	http://purl.obolibrary.org/obo/HP_0006467		hposlim_core
HP:0031435	biolink:PhenotypicFeature	Monotonic speech	A speech pattern characterized by abnormally reduced or lacking variability of the pitch of the voice.		hp.json		http://purl.obolibrary.org/obo/HP_0031435		
HP:0031436	biolink:PhenotypicFeature	Increased pitch variability of speech	A speech pattern characterized by abnormally elevated variability of the pitch of the voice.		hp.json		http://purl.obolibrary.org/obo/HP_0031436		
HP:0031437	biolink:PhenotypicFeature	Pregnancy exposure	Exposure of pregnant women to toxins from any source, such as environmental toxins or chemicals, that may potentially cause problems such as miscarriage, preterm delivery, low birth weight, and, in some cases, developmental delays in infants.		hp.json	Exposure during pregnancy	http://purl.obolibrary.org/obo/HP_0031437		
HP:0006463	biolink:PhenotypicFeature	Rickets of the lower limbs		UMLS:C1833323	hp.json		http://purl.obolibrary.org/obo/HP_0006463		
HP:0006465	biolink:PhenotypicFeature	Periosteal thickening of long tubular bones	Thickening of the periosteum of long bone.	UMLS:C1834345	hp.json		http://purl.obolibrary.org/obo/HP_0006465		
CHEBI:62937	biolink:ChemicalSubstance	icosanoid anion	The carboxylic acid anion that is the conjugate base of an icosanoid, formed when the carboxy group is deprotonated.		hp.json	icosanoid anion|eicosanoid anions|icosanoid anions|eicosanoid anion	http://purl.obolibrary.org/obo/CHEBI_62937		3_STAR
HP:0006466	biolink:PhenotypicFeature	Ankle flexion contracture	A chronic loss of ankle joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevent normal movement of the joints of the ankle.	UMLS:C1837407	hp.json	Ankle contractures|Contractures of the ankles|Ankle contracture	http://purl.obolibrary.org/obo/HP_0006466		
HP:0006460	biolink:PhenotypicFeature	Increased laxity of ankles		UMLS:C1850854	hp.json		http://purl.obolibrary.org/obo/HP_0006460		
HP:0006461	biolink:PhenotypicFeature	Proximal femoral epiphysiolysis	Slipped capital femoral epiphysis is defined as a posterior and inferior slippage of the proximal epiphysis of the femur onto the metaphysis (femoral neck), occurring through the physeal plate during the early adolescent growth spurt.	MSH:D060048|UMLS:C0149887	hp.json	Slipped capital femoral epiphyses|Slipped capital femoral epiphysis|Slipped end part of innermost thighbone	http://purl.obolibrary.org/obo/HP_0006461		
HP:0006462	biolink:PhenotypicFeature	Generalized bone demineralization	A generalized decrease in bone mineral density.	UMLS:C1833326	hp.json	Generalised bone demineralization	http://purl.obolibrary.org/obo/HP_0006462		
OBO:MAXO_0001174	biolink:NamedThing	serum protein measurement	The determination of the amount of protein present in blood serum.		hp.json	blood serum protein test|protein blood serum assessment	http://purl.obolibrary.org/obo/MAXO_0001174		
OBO:MAXO_0001173	biolink:NamedThing	urine albumin measurement	The determination of the amount of albumin (human) present in urine.		hp.json	urine albumin (human) test|albumin (human) urine assessment	http://purl.obolibrary.org/obo/MAXO_0001173		
HP:0031441	biolink:PhenotypicFeature	Abnormal tricuspid valve annulus morphology	Any structural anomaly of the annulus of the tricuspid valve. The annulus is a ring composed of fibrous and myocardial tissue and is the structure onto which the cusps of the valve attach.		hp.json		http://purl.obolibrary.org/obo/HP_0031441		
HP:0031442	biolink:PhenotypicFeature	Abnormal tricuspid chordae tendinae morphology	Any structural anomaly of the chordae tendinae of the tricuspid valve. The chordae tendineae connect the papillary muscles to the tricuspid valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031442		
HP:0031443	biolink:PhenotypicFeature	Abnormal tricuspid valve leaflet morphology	Any structural anomaly of the leaflets (also known as cusps) of the tricuspid valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031443		
HP:0031444	biolink:PhenotypicFeature	Dilatation of the tricuspid annulus	An increase in the diameter of the ring (annulus) of the tricuspid valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031444		
OBO:MAXO_0001172	biolink:NamedThing	insulin measurement	The determination of the amount of insulin hormone present in the sample.		hp.json	insulin hormone test|insulin level assessment|insulin hormone assessment	http://purl.obolibrary.org/obo/MAXO_0001172		
OBO:MAXO_0001171	biolink:NamedThing	testicular ultrasonography	The use of ultrasound to produce images of structures in the testis.		hp.json	testis medical ultrasound|testis ultrasound imaging procedure|sonography of testis|testis diagnostic sonography|testis sonography|testis ultrasound procedure|ultrasonography of testis|testis ultrasound examination	http://purl.obolibrary.org/obo/MAXO_0001171		
OBO:MAXO_0001170	biolink:NamedThing	venous ultrasonography	The use of ultrasound to produce images of structures in the venous blood vessel.		hp.json	venous blood vessel ultrasound examination|venous blood vessel medical ultrasound|ultrasonography of venous blood vessel|venous blood vessel ultrasound imaging procedure|venous blood vessel diagnostic sonography|sonography of venous blood vessel|venous blood vessel sonography|venous sonography|venous blood vessel ultrasound procedure	http://purl.obolibrary.org/obo/MAXO_0001170		
HP:0031440	biolink:PhenotypicFeature	obsolete Abnormal tricuspid valve morphology			hp.json		http://purl.obolibrary.org/obo/HP_0031440		
HP:0031449	biolink:PhenotypicFeature	Perineal hemangioma	Hemangioma, a benign tumor of the vascular endothelial cells, located in the perineal region, i.e., the region between the anus and the genitals.		hp.json		http://purl.obolibrary.org/obo/HP_0031449		
HP:0006438	biolink:PhenotypicFeature	Enlargement of the distal femoral epiphysis	An abnormal enlargement of the distal epiphysis of the femur.	UMLS:C1843105	hp.json	Large distal femoral epiphyses|Enlargement of the outermost thighbone end part	http://purl.obolibrary.org/obo/HP_0006438		
CHEBI:62941	biolink:ChemicalSubstance	glycosylceramide			hp.json		http://purl.obolibrary.org/obo/CHEBI_62941		
HP:0006439	biolink:PhenotypicFeature	Radioulnar dislocation		UMLS:C2673394	hp.json	Dislocated radioulnar joints	http://purl.obolibrary.org/obo/HP_0006439		
HP:0031445	biolink:PhenotypicFeature	Oral mucosa nodule	A palpable, solid lesion greater than 5mm in diameter. that is located in the mucosa of the mouth.		hp.json		http://purl.obolibrary.org/obo/HP_0031445		
HP:0006434	biolink:PhenotypicFeature	Hypoplasia of proximal radius	Proximal radial shortening owing to a congenital defect of development.	UMLS:C1859477	hp.json	Proximal radial shortening	http://purl.obolibrary.org/obo/HP_0006434		
HP:0031446	biolink:PhenotypicFeature	Erosion of oral mucosa	Loss of the superficial layer of the oral mucosa usually resulting in a shallow or crusted lesion.		hp.json		http://purl.obolibrary.org/obo/HP_0031446		
CHEBI:62943	biolink:ChemicalSubstance	prostanoid anion	An icosanoid anion that is the conjugate base of a prostanoid.		hp.json	prostanoid anions	http://purl.obolibrary.org/obo/CHEBI_62943		3_STAR
HP:0031447	biolink:PhenotypicFeature	Penile freckling	Multiple pigmented macules located on the skin of the penis.		hp.json		http://purl.obolibrary.org/obo/HP_0031447		
HP:0006436	biolink:PhenotypicFeature	obsolete Shortening of the tibia			hp.json		http://purl.obolibrary.org/obo/HP_0006436		
CHEBI:62944	biolink:ChemicalSubstance	sialic acid anion	A carboxylic acid anion that is the conjugate base of a sialic acid, formed by deprotonation of the carboxy group.		hp.json	sialic acid anions	http://purl.obolibrary.org/obo/CHEBI_62944		3_STAR
HP:0006437	biolink:PhenotypicFeature	Disproportionate prominence of the femoral medial condyle		UMLS:C1834392	hp.json		http://purl.obolibrary.org/obo/HP_0006437		
HP:0031448	biolink:PhenotypicFeature	Herpetiform vesicles	Multiple vesicles distributed in multiple distinct groups consisting of multiple adjacent vesicles.		hp.json		http://purl.obolibrary.org/obo/HP_0031448		
HP:0006431	biolink:PhenotypicFeature	Proximal femoral metaphyseal abnormality	An anomaly of the metaphysis of the proximal femur (close to the hip).	UMLS:C4025047	hp.json	Abnormal wide portion of innermost thighbone	http://purl.obolibrary.org/obo/HP_0006431		
HP:0006432	biolink:PhenotypicFeature	Trapezoidal distal femoral condyles		UMLS:C1843983	hp.json		http://purl.obolibrary.org/obo/HP_0006432		
HP:0006433	biolink:PhenotypicFeature	Radial dysplasia	Radial dysplasia, also known as radial longitudinal deficiency, includes radial clubhand and is a disfiguring, and potentially disabling, congenital limb anomaly. The entire upper limb may be involved, although the defect is most evident in the forearm and hand. Affected children suffer a variable degree of hypoplasia or absence of the preaxial skeleton and soft tissues, in particular the thumb, radius, and dorsoradial soft tissues. The hand is usually radially deviated and subluxated off the distal aspect of the ulna, the ulna may be shortened and have a bow-shaped deformity, and there is no true wrist (radiocarpal) joint in Bayne2 type-III and IV radial dysplasia.	UMLS:C4025046	hp.json	Radial longitudinal deficiency|Dysplastic radii	http://purl.obolibrary.org/obo/HP_0006433		
OBO:MAXO_0001165	biolink:NamedThing	mucus specimen collection	Collecting of mucus for clinical use.		hp.json	collection of mucus specimen|mucus collection	http://purl.obolibrary.org/obo/MAXO_0001165		
PATO:0000319	biolink:NamedThing	cyan	A color consisting of green and blue hue.		hp.json		http://purl.obolibrary.org/obo/PATO_0000319		value_slim
OBO:MAXO_0001164	biolink:NamedThing	pus specimen collection	Collecting of pus for clinical use.		hp.json	collection of pus specimen|pus collection	http://purl.obolibrary.org/obo/MAXO_0001164		
OBO:MAXO_0001163	biolink:NamedThing	amniotic fluid specimen collection	Collecting of amniotic fluid for clinical use.		hp.json	collection of amniotic fluid specimen|amniotic fluid collection	http://purl.obolibrary.org/obo/MAXO_0001163		
OBO:MAXO_0001162	biolink:NamedThing	semen specimen collection	Collecting of semen for clinical use.		hp.json	collection of semen specimen|sperm collection|semen collection	http://purl.obolibrary.org/obo/MAXO_0001162		
OBO:MAXO_0001169	biolink:NamedThing	cerebrospinal fluid specimen collection	Collecting of cerebrospinal fluid for clinical use.		hp.json	cerebral spinal fluid collection|collection of cerebrospinal fluid specimen|cerebrospinal fluid collection	http://purl.obolibrary.org/obo/MAXO_0001169		
OBO:MAXO_0001168	biolink:NamedThing	bodily fluid specimen collection	Collecting of bodily fluid for clinical use.		hp.json	collection of bodily fluid specimen|bodily fluid collection	http://purl.obolibrary.org/obo/MAXO_0001168		
OBO:MAXO_0001167	biolink:NamedThing	nasal mucus specimen collection	Collecting of nasal mucus for clinical use.		hp.json	collection of nasal mucus specimen|nasal mucus collection	http://purl.obolibrary.org/obo/MAXO_0001167		
OBO:MAXO_0001166	biolink:NamedThing	respiratory system mucus specimen collection	Collecting of respiratory system mucus for clinical use.		hp.json	collection of respiratory system mucus specimen|respiratory system mucus collection	http://purl.obolibrary.org/obo/MAXO_0001166		
HP:0031452	biolink:PhenotypicFeature	Lichenoid skin lesion	Mutliple skin lesions resembling those characteristic of the disease lichen planus. These lesions are violaceous (reddish-purple), shiny, isolated, flat-topped papules and plaques.		hp.json		http://purl.obolibrary.org/obo/HP_0031452		
HP:0031453	biolink:PhenotypicFeature	Oral lichenoid lesion	Mutliple lesions of the oral mucosa resembling those characteristic of the disease lichen planus. These are symmetric reticular lesions that resemble a white, lacelike network, as well as by papules, plaques, erythematous lesions, and erosions.		hp.json		http://purl.obolibrary.org/obo/HP_0031453		
HP:0031454	biolink:PhenotypicFeature	Apocrine hidrocystoma	A cystic lesions that forms a benign tumor of an apocrine sweat gland.		hp.json		http://purl.obolibrary.org/obo/HP_0031454		
HP:0031455	biolink:PhenotypicFeature	Presacral ganglioneuroma	A gangioleneuroma originating from sympathetic ganglion cells in the abdomen.		hp.json		http://purl.obolibrary.org/obo/HP_0031455		
OBO:MAXO_0001161	biolink:NamedThing	urine specimen collection	Collecting of urine for clinical use.		hp.json	collection of urine specimen|urine collection	http://purl.obolibrary.org/obo/MAXO_0001161		
OBO:MAXO_0001160	biolink:NamedThing	sputum specimen collection	Collecting of sputum for clinical use.		hp.json	collection of sputum specimen|sputum collection	http://purl.obolibrary.org/obo/MAXO_0001160		
HP:0031450	biolink:PhenotypicFeature	Polycyclic	A distribution of skin lesions resembling multiple merged circles. For instance, this can be seen with multiple urticarial wheals as the individual, circular wheals resolve and merge.		hp.json		http://purl.obolibrary.org/obo/HP_0031450		
PATO:0000318	biolink:NamedThing	blue	A color hue with low wavelength of that portion of the visible spectrum lying between green and indigo, evoked in the human observer by radiant energy with wavelengths of approximately 420 to 490 nanometers.		hp.json		http://purl.obolibrary.org/obo/PATO_0000318		value_slim|mpath_slim
HP:0031451	biolink:PhenotypicFeature	Lower extremity subcutanous fat hypertrophy	An abnormal increase in the amount of subcutaneous fat in the legs.		hp.json		http://purl.obolibrary.org/obo/HP_0031451		
HP:0006449	biolink:PhenotypicFeature	Distal radial epiphyseal osteolysis		UMLS:C1850145	hp.json		http://purl.obolibrary.org/obo/HP_0006449		
HP:0031456	biolink:PhenotypicFeature	Ectopic pregnancy	A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube).		hp.json		http://purl.obolibrary.org/obo/HP_0031456		
HP:0006446	biolink:PhenotypicFeature	Dysplastic patella		UMLS:C1849580	hp.json		http://purl.obolibrary.org/obo/HP_0006446		
HP:0031457	biolink:PhenotypicFeature	Pulmonary opacity	Opacity refers to any area that preferentially attenuates the x-ray beam and therefore appears more opaque than the surrounding area. It is a nonspecific term that does not indicate the size or pathologic nature of the abnormality.		hp.json		http://purl.obolibrary.org/obo/HP_0031457		
HP:0031458	biolink:PhenotypicFeature	Adenoiditis	An inflammation of the adenoid tissue.		hp.json		http://purl.obolibrary.org/obo/HP_0031458		
HP:0031459	biolink:PhenotypicFeature	Soft tissue neoplasm	A tumor (abnormal growth of tissue) that arises from the soft tissue. The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms.		hp.json		http://purl.obolibrary.org/obo/HP_0031459		
HP:0006441	biolink:PhenotypicFeature	Lateral humeral condyle aplasia		UMLS:C1833878	hp.json		http://purl.obolibrary.org/obo/HP_0006441		
HP:0006442	biolink:PhenotypicFeature	Hypoplasia of proximal fibula	Underdevelopment or shortening of the end of the fibula (calf bone) nearest the knee.	UMLS:C1859478	hp.json	Underdeveloped innermost upper end of calf bone|Small innermost upper end of calf bone	http://purl.obolibrary.org/obo/HP_0006442		
HP:0006443	biolink:PhenotypicFeature	Patellar aplasia	Absence of the patella.	UMLS:C1868578	hp.json	Absent patellae|Absent patellas|Absent patella|Aplastic patellae|Absent kneecap	http://purl.obolibrary.org/obo/HP_0006443		hposlim_core
HP:0006440	biolink:PhenotypicFeature	Increased density of long bone diaphyses		UMLS:C1844516	hp.json	Increased density of shaft of long bone	http://purl.obolibrary.org/obo/HP_0006440		
UBERON:0014701	biolink:AnatomicalEntity	extraembryonic vascular system	A vascular system that overlaps a umbilical cord and is part of a entire extraembryonic component.	EMAPA:16370|VHOG:0001396|EHDAA2:0000478	hp.json		http://purl.obolibrary.org/obo/UBERON_0014701		
CHEBI:1722	biolink:ChemicalSubstance	3beta-hydroxy-Delta(5)-steroid	Any 3beta-hydroxy-steroid that contains a double bond between positions 5 and 6.	KEGG:C03836|MetaCyc:3b-hydroxy-D5-steroids	hp.json	3beta-hydroxy-Delta(5)-steroids|a 3beta-hydroxy-Delta(5)-steroid|3beta-hydroxy Delta(5)-steroids	http://purl.obolibrary.org/obo/CHEBI_1722		3_STAR
HP:0006496	biolink:PhenotypicFeature	Aplasia/hypoplasia involving bones of the upper limbs	Absence (due to failure to form) or underdevelopment of the bones of the upper limbs.	UMLS:C4025035	hp.json	Absent/small bones of the upper limbs|Absent/underdeveloped bones of the upper limbs	http://purl.obolibrary.org/obo/HP_0006496		
CHEBI:60308	biolink:ChemicalSubstance	3,3',5-triiodo-L-thyroninate	The anion resulting from the removal of the proton from the carboxylic acid group of 3,3',5-triiodo-L-thyronine.		hp.json	(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate|liothyronine(1-)|3,3',5-triiodo-L-thyronine anion|(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propionate|3,3',5-triiodo-L-thyronine(1-)|liothyronine anion	http://purl.obolibrary.org/obo/CHEBI_60308		3_STAR
UBERON:0002722	biolink:AnatomicalEntity	trochlear nucleus	Nucleus in the midbrain at the level of the inferior colliculus near the midline, containing the motor neurons giving rise to the trochlear nerve, innervating the contralateral superior oblique extraocular muscle of the eye (Brodal, Neurological Anatomy, 3rd ed, 1981, pg. 533).	BM:MB-IV|DMBA:16903|EMAPA:35886|EV:0100251|UMLS:C0152406|BAMS:IV|BIRNLEX:1488|DHBA:12206|BAMS:4N|BAMS:4|FMA:54518|ZFA:0000450|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=513|MBA:115|MA:0001075|HBA:9063|TAO:0000450	hp.json	nucleus nervi trochlearis|fourth cranial nerve nucleus|nucleus of trochlear nerve|nIV|trochlear motor nucleus|motor nucleus IV|nucleus nervi trochlearis|trochlear IV nucleus	http://purl.obolibrary.org/obo/UBERON_0002722		uberon_slim|vertebrate_core
HP:0006498	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the patella	Absence or underdevelopment of the patella.	UMLS:C1868577|MSH:C535568	hp.json	Hypoplastic or absent patella|Absent/underdeveloped kneecap|Aplastic or hypoplastic patellae|Small to absent patellae|Absent or hypoplastic patellae|Patellar aplasia/hypoplasia|Absent/small kneecap|Absent/hypoplastic patella	http://purl.obolibrary.org/obo/HP_0006498		
HP:0006499	biolink:PhenotypicFeature	Abnormality of femoral epiphysis	An anomaly of a growth plate of a femur.	UMLS:C4025034	hp.json	Abnormality of thighbone end part	http://purl.obolibrary.org/obo/HP_0006499		
HP:0006492	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the fibula	Absence or underdevelopment of the fibula.	UMLS:C1856732	hp.json	Absent/underdeveloped calf bone|Hypoplastic/aplastic fibulae|Absent/small calf bone|Fibular aplasia/hypoplasia	http://purl.obolibrary.org/obo/HP_0006492		
HP:0006493	biolink:PhenotypicFeature	Aplasia/hypoplasia involving bones of the lower limbs	Absence (due to failure to form) or underdevelopment of the bones of the lower limbs.	UMLS:C4025037	hp.json	Absent/underdeveloped lower limb bones|Absent/small lower limb bones	http://purl.obolibrary.org/obo/HP_0006493		
HP:0006494	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving bones of the feet		UMLS:C4025036	hp.json	Absent/underdeveloped foot bones|Absent/small foot bones	http://purl.obolibrary.org/obo/HP_0006494		
HP:0006495	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the ulna	Absence or underdevelopment of the ulna.	UMLS:C1865571	hp.json	Absent/small ulna|Hypoplasia or unilateral/bilateral absence of ulna|Absent-hypoplastic ulnae|Absence/underdevelopment of inner forearm bone|Ulnar hypoplasia/aplasia	http://purl.obolibrary.org/obo/HP_0006495		
UBERON:0002707	biolink:AnatomicalEntity	corticospinal tract	The corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract.	FMA:72634|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=800|BAMS:P|MBA:190|HBA:265505574|MBA:784|BM:Me-PyT|BM:CST|GAID:702|EMAPA:36600|UMLS:C0034229|DMBA:17756|BIRNLEX:1464|MESH:D011712|DHBA:12776	hp.json	pyramid (Willis)|pyramidal tract|tractus corticospinalis|fasciculus cerebro-spinalis|corticospinal fibers|fasciculus pyramidalis|tractus cortico-spinalis|fibrae corticospinales|tractus corticospinalis|tractus pyramidalis	http://purl.obolibrary.org/obo/UBERON_0002707		pheno_slim|human_reference_atlas|uberon_slim
CHEBI:60311	biolink:ChemicalSubstance	thyroid hormone	Any hormone produced by the thyroid gland		hp.json	thyroid hormones	http://purl.obolibrary.org/obo/CHEBI_60311		3_STAR
CHEBI:62978	biolink:ChemicalSubstance	4-hydroxyprolinate	The alpha-amino-acid anion formed by loss of a proton from the carboxy group of 4-hydroxyproline.		hp.json	4-hydroxyproline anion|hydroxyprolinate|hydroxyproline anion|4-hydroxypyrrolidine-2-carboxylate	http://purl.obolibrary.org/obo/CHEBI_62978		3_STAR
OBO:uberon/core#layer_part_of	biolink:NamedThing	layer part of			hp.json		http://purl.obolibrary.org/obo/uberon/core#layer_part_of		
HP:0006480	biolink:PhenotypicFeature	Premature loss of teeth	Exfoliation of a tooth more than 2 SD earlier than the normal age for the deciduous teeth and not related to traume or neglect. Exfoliation of a permanent tooth is per se abnormal.	SNOMEDCT_US:42756003|UMLS:C0232513|SNOMEDCT_US:234974002|UMLS:C0399385	hp.json	Loss of teeth|Early tooth loss|Premature exfoliation of teeth|Premature tooth loss|Premature teeth loss	http://purl.obolibrary.org/obo/HP_0006480		hposlim_core
CHEBI:62981	biolink:ChemicalSubstance	4-hydroxy-L-prolinate	The L-alpha-amino acid anion that is the conjugate base of 4-hydroxy-L-proline, formed by proton loss from the carboxy group. It is the major microspecies present at pH > 10.6.	Reaxys:4742919	hp.json	(2S)-4-hydroxypyrrolidine-2-carboxylate|4-hydroxy-L-proline anion	http://purl.obolibrary.org/obo/CHEBI_62981		3_STAR
HP:0031405	biolink:PhenotypicFeature	Poroma	A benign, well circumscribed sweat gland neoplasm with eccrine or apocrine differentiation. It usually presents as a solitary, dome-shaped papule, nodule, or plaque on acral sites. It is characterized by a proliferation of uniform basaloid cells in the dermis and it is associated with the presence of focal ductal and cystic structures [NCIT:C27273].		hp.json		http://purl.obolibrary.org/obo/HP_0031405		
HP:0031406	biolink:PhenotypicFeature	Abnormal cytokine signaling	Any abnormality in the series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.		hp.json	Abnormal cytokine signalling	http://purl.obolibrary.org/obo/HP_0031406		
HP:0031407	biolink:PhenotypicFeature	Impaired cytokine signaling	A defect or impairment in the series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.		hp.json	Cytokine signalling defect|Impaired cytokine signalling|Cytokine signaling defect	http://purl.obolibrary.org/obo/HP_0031407		
HP:0031408	biolink:PhenotypicFeature	Increased proportion of CD25+ mast cells	An increased proportion of mast cells are positive for the cell surface marker CD25 (also called interleukin-2 receptor alpha chain).		hp.json		http://purl.obolibrary.org/obo/HP_0031408		
HP:0031401	biolink:PhenotypicFeature	Reduced proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells	An abnormally decreased proportion of CD4-negative, CD8-negative (double negative or DN) alpha-beta regulatory T cells (Tregs) as compared to total number of T cells.		hp.json		http://purl.obolibrary.org/obo/HP_0031401		
HP:0006479	biolink:PhenotypicFeature	Abnormal dental pulp morphology	An abnormality of the dental pulp.	UMLS:C4025042	hp.json	Endodontic abnormality|Abnormality of tooth pulp|Abnormality of the dental pulp	http://purl.obolibrary.org/obo/HP_0006479		
HP:0031402	biolink:PhenotypicFeature	Reduced antigen-specific T cell proliferation	Impaired proliferation and expansion of a T cell population following activation by an antigenic stimulus.		hp.json	Antigen-specific T cell proliferation defect|Impaired Ag-specific T cell proliferation|Impaired activated T cell proliferation|Impaired cellular adaptive immune response	http://purl.obolibrary.org/obo/HP_0031402		
GO:0009314	biolink:BiologicalProcess	response to radiation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.		hp.json	response to radiation stimulus|response to electromagnetic radiation stimulus	http://purl.obolibrary.org/obo/GO_0009314		
HP:0031403	biolink:PhenotypicFeature	Impaired pathogen-specific CD8 cytoxicity	Impaired response of CD8 T cells to pathogens. CD8 T cells direct the killing of a target cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.		hp.json	Pathogen-specific CD8 cytoxicity defect	http://purl.obolibrary.org/obo/HP_0031403		
HP:0031404	biolink:PhenotypicFeature	Impaired antigen-specific response	An impaired immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).		hp.json	Impaired adaptive immune response	http://purl.obolibrary.org/obo/HP_0031404		
CHEBI:35391	biolink:ChemicalSubstance	aspartate(1-)	An alpha-amino-acid anion that is the conjugate base of aspartic acid.		hp.json	2-ammoniosuccinate|hydrogen aspartate|2-ammoniobutanedioate|aspartate(1-)|aspartic acid monoanion	http://purl.obolibrary.org/obo/CHEBI_35391		3_STAR
HP:0006476	biolink:PhenotypicFeature	Abnormality of the pancreatic islet cells	An abnormality of the islet of Langerhans, i.e., of the regions of the pancreas that contain its endocrine cells. These are the alpha cells, which produce glucagon, the beta cells, which produce insulin and amylin, the delta cells, which produce somatostatin, the PP cells, which produce pancreatic polypeptide, and the epsilon cells, which produce ghrelin.	UMLS:C4025043	hp.json		http://purl.obolibrary.org/obo/HP_0006476		
HP:0006477	biolink:PhenotypicFeature	Abnormality of the alveolar ridges	Any abnormality of the alveolar ridges (on the upper or lower jaws). The alveolar ridges contain the sockets (alveoli) of the teeth.	UMLS:C4280445|SNOMEDCT_US:235013007|UMLS:C0341007	hp.json	Abnormality of alveolar processes of jaw|Abnormality of gum ridge|Abnormality of alveolar margin|Abnormality of dentoalveolar ridges|Defect in alveolar ridge	http://purl.obolibrary.org/obo/HP_0006477		
HP:0006470	biolink:PhenotypicFeature	Thin long bone diaphyses	Decreased width of the diaphysis of long bones.	UMLS:C1859449	hp.json	Thin shaft of long bone|Thin diaphyses of long bones	http://purl.obolibrary.org/obo/HP_0006470		
HP:0031409	biolink:PhenotypicFeature	Abnormal lymphocyte physiology	Any anomaly of lymphocyte function.		hp.json		http://purl.obolibrary.org/obo/HP_0031409		
HP:0006471	biolink:PhenotypicFeature	Fixed elbow flexion		UMLS:C4025044	hp.json		http://purl.obolibrary.org/obo/HP_0006471		
HP:0006473	biolink:PhenotypicFeature	Anterior bowing of long bones	An abnormal anterior curvature of a long bone.	UMLS:C1850644	hp.json		http://purl.obolibrary.org/obo/HP_0006473		
OBO:MAXO_0001121	biolink:NamedThing	biopsy of kidney	Removal of tissue from the kidney.		hp.json	kidney biopsy	http://purl.obolibrary.org/obo/MAXO_0001121		
HP:0006490	biolink:PhenotypicFeature	Abnormal lower-limb metaphysis morphology		UMLS:C4025039	hp.json	Abnormality of the wide portion of the lower-limb bone|Abnormality of lower-limb metaphyses	http://purl.obolibrary.org/obo/HP_0006490		
HP:0006491	biolink:PhenotypicFeature	Abnormal tibial metaphysis morphology		UMLS:C4025038	hp.json	Abnormality of the wide portion of shinbone|Abnormality of the tibial metaphysis|Abnormality of the wide portion of shankbone	http://purl.obolibrary.org/obo/HP_0006491		
OBO:MAXO_0001122	biolink:NamedThing	kidney CT	The use of computed tomography to produce images of structures of the kidney.		hp.json	CAT scan of kidney|kidney computerized axial tomography|renal CT|kidney CAT scan|kidney computed tomography|CT of kidney|kidney CT examination|renal CAT scan	http://purl.obolibrary.org/obo/MAXO_0001122		
HP:0031410	biolink:PhenotypicFeature	Abnormal distribution of CD56 bright/dim natural killer cells	An abnormal distribution in the number of CD56 bright NK cells, as measured by flow cytometry. CD56, an adhesion molecule mediating homotypic adhesion, is used as a functional marker for NK cells.		hp.json	Abnormal distribution of CD56 bright/dim NK cells	http://purl.obolibrary.org/obo/HP_0031410		
HP:0031411	biolink:PhenotypicFeature	Abnormal chromosome morphology	Any structural anomaly of a chromosome, which is a thread like molecule consisting of DNA and proteins (chromatin) that contains DNA sequences for genes and other genetic elements in linear order.	Fyler:4013	hp.json		http://purl.obolibrary.org/obo/HP_0031411		
HP:0031416	biolink:PhenotypicFeature	Abnormal nasal mucus secretion	Any deviation from the normal quantity of secretion of nasal mucus, a thick viscous liquid produced by the mucous membranes of the nose.		hp.json		http://purl.obolibrary.org/obo/HP_0031416		
HP:0031417	biolink:PhenotypicFeature	Rhinorrhea	Increased discharge of mucus from the nose.		hp.json	Nasal Discharge|Runny Nose	http://purl.obolibrary.org/obo/HP_0031417		
HP:0031418	biolink:PhenotypicFeature	Increased body mass index	Abnormally increased weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of overweight compared to averages.		hp.json	Increased BMI	http://purl.obolibrary.org/obo/HP_0031418		
HP:0031419	biolink:PhenotypicFeature	Reduced sex -hormone binding protein level	A decreased concentration of sex-hormone binding protein in the circulation.		hp.json	Reduced androgen-binding protein level	http://purl.obolibrary.org/obo/HP_0031419		
HP:0006489	biolink:PhenotypicFeature	Abnormal femoral metaphysis morphology	An anomaly of the femoral metaphysis.	UMLS:C4280444|UMLS:C4025040	hp.json	Abnormality of the wide portion of the femoral bone|Abnormality of the femoral metaphysis	http://purl.obolibrary.org/obo/HP_0006489		
HP:0031412	biolink:PhenotypicFeature	Abnormal telomere morphology			hp.json		http://purl.obolibrary.org/obo/HP_0031412		
HP:0031413	biolink:PhenotypicFeature	Short telomere length	An abnormal reduction in telomere length. Telomeres are non-coding, repetitive sequences of DNA at the ends of the chromosomes of eukaryotic cells which become shorter as cells divide, and when telomere attrition reaches its limit, cell proliferation arrest, senescence, and apoptosis can occur.		hp.json		http://purl.obolibrary.org/obo/HP_0031413		
HP:0031414	biolink:PhenotypicFeature	High serum calcifediol	An increased concentration of calcifediol in the blood. Calcifediol is also known as 25-hydroxycholecalciferol or 25-Hydroxyvitamin D3.		hp.json	High serum 25-hydroxycholecalciferol|High serum calcidiol	http://purl.obolibrary.org/obo/HP_0031414		
HP:0031415	biolink:PhenotypicFeature	High serum calcitriol	An increased concentration of calcitriol in the blood. Calcitriol is also known as 1,25-dihydroxycholecalciferol or 1,25-dihydroxyvitamin D3.	UMLS:C1833331	hp.json	Increased serum 1,25-dihydroxyvitamin D3|High serum 1,25-dihydroxyvitamin D3|High serum 1,25-dihydroxycholecalciferol|Increased serum calcitriol	http://purl.obolibrary.org/obo/HP_0031415		
HP:0006485	biolink:PhenotypicFeature	Agenesis of incisor	Agenesis of incisor.	UMLS:C4020816|UMLS:C4083290|UMLS:C4020815	hp.json	Failure of development of incisor|Missing incisors|Absence of incisors|Absence of front tooth|Missing front tooth	http://purl.obolibrary.org/obo/HP_0006485		
HP:0006486	biolink:PhenotypicFeature	Abnormal dental root morphology	An abnormality of the dental root.	UMLS:C4025041	hp.json	Dental root anomaly|Abnormality of tooth root|Abnormality of the dental root	http://purl.obolibrary.org/obo/HP_0006486		
HP:0006487	biolink:PhenotypicFeature	Bowing of the long bones	A bending or abnormal curvature of a long bone.	UMLS:C1855340	hp.json	Diaphyseal bowing|Bowing of long bones|Bowing of the long bones|Camptomelia|Diaphyseal bowing of long bones|Bowed long bones	http://purl.obolibrary.org/obo/HP_0006487		
HP:0006488	biolink:PhenotypicFeature	Bowing of the arm	A bending or abnormal curvature affecting a long bone of the arm.	UMLS:C0426863	hp.json	Bending of the arm|Bowing of the arm	http://purl.obolibrary.org/obo/HP_0006488		
HP:0006481	biolink:PhenotypicFeature	Abnormality of primary teeth	Any abnormality of the primary tooth.	UMLS:C4021596	hp.json	Abnormality of baby teeth|Abnormality of deciduous teeth|Abnormality of milk teeth	http://purl.obolibrary.org/obo/HP_0006481		
HP:0006482	biolink:PhenotypicFeature	Abnormality of dental morphology	An abnormality of the morphology of the tooth.	MSH:D014071|UMLS:C0262444|SNOMEDCT_US:422775003|UMLS:C0040427	hp.json	Dental malformations|Misshapen teeth|Dental deformity|Misshapened teeth|Malformation of teeth|Deformity of teeth|Abnormally shaped teeth|Malformed teeth|Abnormality of dental shape|Abnormality of shape of tooth	http://purl.obolibrary.org/obo/HP_0006482		hposlim_core
HP:0006483	biolink:PhenotypicFeature	Abnormal number of teeth	The presence of an altered number of of teeth.	SNOMEDCT_US:335443002|UMLS:C1290508	hp.json	Abnormal number of teeth|Abnormal complement of teeth|Abnormal tooth count	http://purl.obolibrary.org/obo/HP_0006483		
GO:0071242	biolink:BiologicalProcess	cellular response to ammonium ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus.		hp.json	cellular response to ammonia	http://purl.obolibrary.org/obo/GO_0071242		
GO:0071241	biolink:BiologicalProcess	cellular response to inorganic substance	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071241		
GO:1900118	biolink:BiologicalProcess	negative regulation of execution phase of apoptosis	Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.		hp.json	downregulation of execution phase of apoptosis|down regulation of execution phase of apoptosis|inhibition of execution phase of apoptosis|down-regulation of execution phase of apoptosis	http://purl.obolibrary.org/obo/GO_1900118		
GO:1900117	biolink:BiologicalProcess	regulation of execution phase of apoptosis	Any process that modulates the frequency, rate or extent of execution phase of apoptosis.		hp.json		http://purl.obolibrary.org/obo/GO_1900117		
GO:1900119	biolink:BiologicalProcess	positive regulation of execution phase of apoptosis	Any process that activates or increases the frequency, rate or extent of execution phase of apoptosis.		hp.json	up-regulation of execution phase of apoptosis|activation of execution phase of apoptosis|upregulation of execution phase of apoptosis|up regulation of execution phase of apoptosis	http://purl.obolibrary.org/obo/GO_1900119		
GO:1900116	biolink:BiologicalProcess	extracellular negative regulation of signal transduction	Any negative regulation of signal transduction that takes place in extracellular region.		hp.json	negative regulation of signalling pathway in extracellular region|negative regulation of signaling pathway in extracellular region|down regulation of signal transduction in extracellular region|extracellular inhibition of signaling pathway|inhibition of signal transduction in extracellular region|downregulation of signal transduction in extracellular region|down-regulation of signal transduction in extracellular region	http://purl.obolibrary.org/obo/GO_1900116		
GO:1900115	biolink:BiologicalProcess	extracellular regulation of signal transduction	Any regulation of signal transduction that takes place in the extracellular region.		hp.json	regulation of signaling pathway in extracellular region|regulation of signalling pathway in extracellular region	http://purl.obolibrary.org/obo/GO_1900115		
GO:0071248	biolink:BiologicalProcess	cellular response to metal ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.		hp.json	cellular response to metal|cellular response to heavy metal	http://purl.obolibrary.org/obo/GO_0071248		
GO:0071230	biolink:BiologicalProcess	cellular response to amino acid stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.		hp.json	cellular response to amino acid	http://purl.obolibrary.org/obo/GO_0071230		
CHEBI:25901	biolink:ChemicalSubstance	pentose	A five-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldopentose) or a ketone group at position 2 (ketopentose).		hp.json	pentoses|pentose	http://purl.obolibrary.org/obo/CHEBI_25901		3_STAR
GO:1900125	biolink:BiologicalProcess	regulation of hyaluronan biosynthetic process	Any process that modulates the frequency, rate or extent of hyaluronan biosynthetic process.		hp.json	regulation of hyaluronan formation|regulation of hyaluronan biosynthesis|regulation of hyaluronan anabolism|regulation of hyaluronan synthesis	http://purl.obolibrary.org/obo/GO_1900125		
GO:1900127	biolink:BiologicalProcess	positive regulation of hyaluronan biosynthetic process	Any process that activates or increases the frequency, rate or extent of hyaluronan biosynthetic process.		hp.json	upregulation of hyaluronan biosynthesis|upregulation of hyaluronan biosynthetic process|activation of hyaluronan synthesis|activation of hyaluronan biosynthesis|positive regulation of hyaluronan anabolism|upregulation of hyaluronan synthesis|activation of hyaluronan formation|up regulation of hyaluronan anabolism|upregulation of hyaluronan formation|positive regulation of hyaluronan synthesis|up-regulation of hyaluronan anabolism|up-regulation of hyaluronan biosynthesis|up-regulation of hyaluronan biosynthetic process|up regulation of hyaluronan synthesis|positive regulation of hyaluronan formation|up regulation of hyaluronan biosynthetic process|up regulation of hyaluronan biosynthesis|up-regulation of hyaluronan synthesis|up regulation of hyaluronan formation|positive regulation of hyaluronan biosynthesis|activation of hyaluronan biosynthetic process|activation of hyaluronan anabolism|up-regulation of hyaluronan formation|upregulation of hyaluronan anabolism	http://purl.obolibrary.org/obo/GO_1900127		
GO:1900126	biolink:BiologicalProcess	negative regulation of hyaluronan biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of hyaluronan biosynthetic process.		hp.json	down regulation of hyaluronan synthesis|down-regulation of hyaluronan biosynthetic process|down-regulation of hyaluronan biosynthesis|negative regulation of hyaluronan biosynthesis|inhibition of hyaluronan anabolism|down regulation of hyaluronan formation|down-regulation of hyaluronan synthesis|negative regulation of hyaluronan synthesis|down regulation of hyaluronan biosynthetic process|down regulation of hyaluronan biosynthesis|negative regulation of hyaluronan formation|down-regulation of hyaluronan formation|inhibition of hyaluronan synthesis|inhibition of hyaluronan biosynthetic process|downregulation of hyaluronan biosynthesis|downregulation of hyaluronan biosynthetic process|downregulation of hyaluronan anabolism|inhibition of hyaluronan formation|downregulation of hyaluronan synthesis|down regulation of hyaluronan anabolism|inhibition of hyaluronan biosynthesis|downregulation of hyaluronan formation|negative regulation of hyaluronan anabolism|down-regulation of hyaluronan anabolism	http://purl.obolibrary.org/obo/GO_1900126		
GO:1900121	biolink:BiologicalProcess	negative regulation of receptor binding	Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.		hp.json	downregulation of receptor binding|down regulation of receptor binding|down regulation of receptor-associated protein activity|inhibition of receptor binding|down-regulation of receptor binding|inhibition of receptor ligand	http://purl.obolibrary.org/obo/GO_1900121		
GO:1900120	biolink:BiologicalProcess	regulation of receptor binding	Any process that modulates the frequency, rate or extent of a protein or other molecule binding to a receptor.		hp.json	regulation of receptor ligand	http://purl.obolibrary.org/obo/GO_1900120		
GO:1900122	biolink:BiologicalProcess	positive regulation of receptor binding	Any process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor.		hp.json	activation of receptor binding|upregulation of receptor binding|up regulation of receptor binding	http://purl.obolibrary.org/obo/GO_1900122		
GO:1900130	biolink:BiologicalProcess	regulation of lipid binding	Any process that modulates the frequency, rate or extent of lipid binding.		hp.json		http://purl.obolibrary.org/obo/GO_1900130		
CHEBI:25905	biolink:ChemicalSubstance	peptide hormone	Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine.		hp.json	peptide hormones|polypeptide hormone	http://purl.obolibrary.org/obo/CHEBI_25905		3_STAR
OBO:MAXO_0001211	biolink:NamedThing	screening for hepatoblastoma	The use of any device, marker, or other means for the purpose of detecting the presence Hepatoblastoma, usually in asymptomatic individuals.		hp.json	Hepatoblastoma screening	http://purl.obolibrary.org/obo/MAXO_0001211		
OBO:MAXO_0001210	biolink:NamedThing	screening for gastric polyps	The use of any device, marker, or other means for the purpose of detecting the presence Multiple gastric polyps, usually in asymptomatic individuals.		hp.json	Multiple gastric polyps screening	http://purl.obolibrary.org/obo/MAXO_0001210		
GO:1900132	biolink:BiologicalProcess	positive regulation of lipid binding	Any process that activates or increases the frequency, rate or extent of lipid binding.		hp.json	upregulation of lipid binding|up-regulation of lipid binding|up regulation of lipid binding|activation of lipid binding	http://purl.obolibrary.org/obo/GO_1900132		
GO:1900131	biolink:BiologicalProcess	negative regulation of lipid binding	Any process that stops, prevents or reduces the frequency, rate or extent of lipid binding.		hp.json	down-regulation of lipid binding|down regulation of lipid binding|inhibition of lipid binding|downregulation of lipid binding	http://purl.obolibrary.org/obo/GO_1900131		
GO:1900141	biolink:BiologicalProcess	regulation of oligodendrocyte apoptotic process	Any process that modulates the frequency, rate or extent of oligodendrocyte apoptotic process.		hp.json	regulation of oligodendrocyte apoptosis	http://purl.obolibrary.org/obo/GO_1900141		
GO:1900147	biolink:BiologicalProcess	regulation of Schwann cell migration	Any process that modulates the frequency, rate or extent of Schwann cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_1900147		
GO:1900149	biolink:BiologicalProcess	positive regulation of Schwann cell migration	Any process that activates or increases the frequency, rate or extent of Schwann cell migration.		hp.json	up regulation of Schwann cell migration|up-regulation of Schwann cell migration|activation of Schwann cell migration|upregulation of Schwann cell migration	http://purl.obolibrary.org/obo/GO_1900149		
GO:1900148	biolink:BiologicalProcess	negative regulation of Schwann cell migration	Any process that stops, prevents or reduces the frequency, rate or extent of Schwann cell migration.		hp.json	downregulation of Schwann cell migration|down regulation of Schwann cell migration|inhibition of Schwann cell migration|down-regulation of Schwann cell migration	http://purl.obolibrary.org/obo/GO_1900148		
GO:1900143	biolink:BiologicalProcess	positive regulation of oligodendrocyte apoptotic process	Any process that activates or increases the frequency, rate or extent of oligodendrocyte apoptotic process.		hp.json	upregulation of oligodendrocyte apoptotic process|up-regulation of oligodendrocyte apoptosis|up regulation of oligodendrocyte apoptosis|positive regulation of oligodendrocyte apoptosis|up-regulation of oligodendrocyte apoptotic process|up regulation of oligodendrocyte apoptotic process|upregulation of oligodendrocyte apoptosis|activation of oligodendrocyte apoptosis|activation of oligodendrocyte apoptotic process	http://purl.obolibrary.org/obo/GO_1900143		
GO:1900142	biolink:BiologicalProcess	negative regulation of oligodendrocyte apoptotic process	Any process that stops, prevents or reduces the frequency, rate or extent of oligodendrocyte apoptotic process.		hp.json	down-regulation of oligodendrocyte apoptotic process|downregulation of oligodendrocyte apoptosis|down regulation of oligodendrocyte apoptotic process|downregulation of oligodendrocyte apoptotic process|inhibition of oligodendrocyte apoptosis|inhibition of oligodendrocyte apoptotic process|negative regulation of oligodendrocyte apoptosis|down-regulation of oligodendrocyte apoptosis|down regulation of oligodendrocyte apoptosis	http://purl.obolibrary.org/obo/GO_1900142		
GO:1900150	biolink:BiologicalProcess	regulation of defense response to fungus	Any process that modulates the frequency, rate or extent of defense response to fungus.		hp.json	regulation of response to pathogenic fungus (incompatible interaction)|regulation of defence response to fungus|regulation of defense response to fungi, incompatible interaction|regulation of defence response to fungi|regulation of defense response to fungi|regulation of resistance response to pathogenic fungus|regulation of defense response to fungus, incompatible interaction|regulation of resistance response to pathogenic fungi	http://purl.obolibrary.org/obo/GO_1900150		
OBO:MAXO_0001206	biolink:NamedThing	screening for intestinal polyps	The use of any device, marker, or other means for the purpose of detecting the presence Intestinal polyp, usually in asymptomatic individuals.		hp.json	Intestinal polyp screening	http://purl.obolibrary.org/obo/MAXO_0001206		
OBO:MAXO_0001205	biolink:NamedThing	screening for colorectal polyps	The use of any device, marker, or other means for the purpose of detecting the presence Colorectal polyposis, usually in asymptomatic individuals.		hp.json	Colorectal polyposis screening	http://purl.obolibrary.org/obo/MAXO_0001205		
OBO:MAXO_0001204	biolink:NamedThing	screening for venous thrombosis	The use of any device, marker, or other means for the purpose of detecting the presence Venous thrombosis, usually in asymptomatic individuals.		hp.json	Venous thrombosis screening	http://purl.obolibrary.org/obo/MAXO_0001204		
OBO:MAXO_0001203	biolink:NamedThing	screening for breast cancer	The use of any device, marker, or other means for the purpose of detecting the presence Neoplasm of the breast, usually in asymptomatic individuals.		hp.json	Neoplasm of the breast screening	http://purl.obolibrary.org/obo/MAXO_0001203		
OBO:MAXO_0001209	biolink:NamedThing	screening for small intestinal polyps	The use of any device, marker, or other means for the purpose of detecting the presence Small intestinal polyp, usually in asymptomatic individuals.		hp.json	Small intestinal polyp screening	http://purl.obolibrary.org/obo/MAXO_0001209		
OBO:MAXO_0001208	biolink:NamedThing	screening for cervical polyps	The use of any device, marker, or other means for the purpose of detecting the presence Cervical polyp, usually in asymptomatic individuals.		hp.json	Cervical polyp screening	http://purl.obolibrary.org/obo/MAXO_0001208		
OBO:MAXO_0001207	biolink:NamedThing	screening for uterine polyps	The use of any device, marker, or other means for the purpose of detecting the presence Ureteral polyp, usually in asymptomatic individuals.		hp.json	Ureteral polyp screening	http://purl.obolibrary.org/obo/MAXO_0001207		
GO:0071281	biolink:BiologicalProcess	cellular response to iron ion	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.		hp.json	cellular response to iron	http://purl.obolibrary.org/obo/GO_0071281		
GO:1900158	biolink:BiologicalProcess	negative regulation of bone mineralization involved in bone maturation	Any process that stops, prevents or reduces the frequency, rate or extent of bone mineralization involved in bone maturation.		hp.json	downregulation of bone mineralization involved in bone maturation|inhibition of bone mineralization involved in bone maturation|down-regulation of bone mineralization involved in bone maturation|down regulation of bone mineralization involved in bone maturation	http://purl.obolibrary.org/obo/GO_1900158		
GO:1900157	biolink:BiologicalProcess	regulation of bone mineralization involved in bone maturation	Any process that modulates the frequency, rate or extent of bone mineralization involved in bone maturation.		hp.json		http://purl.obolibrary.org/obo/GO_1900157		
GO:1900159	biolink:BiologicalProcess	positive regulation of bone mineralization involved in bone maturation	Any process that activates or increases the frequency, rate or extent of bone mineralization involved in bone maturation.		hp.json	up-regulation of bone mineralization involved in bone maturation|up regulation of bone mineralization involved in bone maturation|activation of bone mineralization involved in bone maturation|upregulation of bone mineralization involved in bone maturation	http://purl.obolibrary.org/obo/GO_1900159		
HP:0006417	biolink:PhenotypicFeature	Broad femoral metaphyses		UMLS:C1864854	hp.json	Broad wide portion of thigh bone	http://purl.obolibrary.org/obo/HP_0006417		
HP:0006413	biolink:PhenotypicFeature	Broad tibial metaphyses		UMLS:C2678328	hp.json	Broad wide portion of shinbone|Broad wide portion of shankbone	http://purl.obolibrary.org/obo/HP_0006413		
HP:0006414	biolink:PhenotypicFeature	Distal tibial bowing	A bending or abnormal curvature of the distal portion of the tibia.	UMLS:C4021598	hp.json	Tibial bowing at ankle|Bowing of the distal tibia	http://purl.obolibrary.org/obo/HP_0006414		
HP:0006415	biolink:PhenotypicFeature	Cortically dense long tubular bones	Increased density of the compact bone of long bone.	UMLS:C1849276	hp.json		http://purl.obolibrary.org/obo/HP_0006415		
GO:0034250	biolink:BiologicalProcess	positive regulation of cellular amide metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving amides.		hp.json	positive regulation of amide metabolism	http://purl.obolibrary.org/obo/GO_0034250		
UBERON:0036186	biolink:AnatomicalEntity	fibroelastic connective tissue		FMA:83520	hp.json		http://purl.obolibrary.org/obo/UBERON_0036186		
GO:0034242	biolink:BiologicalProcess	negative regulation of syncytium formation by plasma membrane fusion	Any process that decreases the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.		hp.json		http://purl.obolibrary.org/obo/GO_0034242		
HP:0006429	biolink:PhenotypicFeature	Broad femoral neck	An abnormally wide femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft).	UMLS:C1849016	hp.json	Broadening of femoral neck|Wide femoral neck|Widened femoral necks|Wide neck of thigh bone	http://purl.obolibrary.org/obo/HP_0006429		
HP:0006423	biolink:PhenotypicFeature	Peg-like central prominence of distal tibial metaphyses		UMLS:C1846160	hp.json		http://purl.obolibrary.org/obo/HP_0006423		
HP:0006424	biolink:PhenotypicFeature	Elongated radius	Increased length of the radius.	UMLS:C4025048	hp.json		http://purl.obolibrary.org/obo/HP_0006424		
GO:0034248	biolink:BiologicalProcess	regulation of cellular amide metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides.		hp.json	regulation of amide metabolism	http://purl.obolibrary.org/obo/GO_0034248		
GO:0034249	biolink:BiologicalProcess	negative regulation of cellular amide metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amides.		hp.json	negative regulation of amide metabolism	http://purl.obolibrary.org/obo/GO_0034249		
HP:0006426	biolink:PhenotypicFeature	Rudimentary to absent tibiae		UMLS:C1968943	hp.json		http://purl.obolibrary.org/obo/HP_0006426		
HP:0006420	biolink:PhenotypicFeature	Asymmetric radial dysplasia	The presence of asymmetric developmental dysplasia of the radius.	UMLS:C1969396	hp.json		http://purl.obolibrary.org/obo/HP_0006420		
GO:1900182	biolink:BiologicalProcess	positive regulation of protein localization to nucleus	Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.		hp.json	up-regulation of protein localization in nucleus|up-regulation of protein localisation to nucleus|up-regulation of protein localization in cell nucleus|activation of protein localization in cell nucleus|up regulation of protein localization in nucleus|upregulation of protein localization to nucleus|up regulation of protein localisation to nucleus|positive regulation of protein localization in nucleus|activation of protein localisation to nucleus|positive regulation of protein localisation to nucleus|upregulation of protein localization in cell nucleus|upregulation of protein localization in nucleus|up-regulation of protein localization to nucleus|activation of protein localization in nucleus|upregulation of protein localisation to nucleus|up regulation of protein localization to nucleus|positive regulation of protein localization in cell nucleus|activation of protein localization to nucleus|up regulation of protein localization in cell nucleus	http://purl.obolibrary.org/obo/GO_1900182		
GO:1900181	biolink:BiologicalProcess	negative regulation of protein localization to nucleus	Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.		hp.json	inhibition of protein localisation to nucleus|downregulation of protein localisation to nucleus|downregulation of protein localization in cell nucleus|down-regulation of protein localization to nucleus|down regulation of protein localization to nucleus|down regulation of protein localization in cell nucleus|inhibition of protein localization in cell nucleus|negative regulation of protein localization in cell nucleus|negative regulation of protein localization in nucleus|down-regulation of protein localization in nucleus|down-regulation of protein localization in cell nucleus|negative regulation of protein localisation to nucleus|down-regulation of protein localisation to nucleus|downregulation of protein localization to nucleus|inhibition of protein localization to nucleus|down regulation of protein localization in nucleus|down regulation of protein localisation to nucleus|inhibition of protein localization in nucleus|downregulation of protein localization in nucleus	http://purl.obolibrary.org/obo/GO_1900181		
GO:1900180	biolink:BiologicalProcess	regulation of protein localization to nucleus	Any process that modulates the frequency, rate or extent of protein localization to nucleus.		hp.json	regulation of protein localization in cell nucleus|regulation of protein localization in nucleus|regulation of protein localisation to nucleus	http://purl.obolibrary.org/obo/GO_1900180		
HP:0006409	biolink:PhenotypicFeature	Progressive leg bowing	Progressive bending or abnormal curvature of the leg.	UMLS:C1855191	hp.json		http://purl.obolibrary.org/obo/HP_0006409		
GO:1900194	biolink:BiologicalProcess	negative regulation of oocyte maturation	Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.		hp.json	downregulation of oocyte maturation|down-regulation of oocyte maturation|down regulation of oocyte maturation|inhibition of oocyte maturation	http://purl.obolibrary.org/obo/GO_1900194		
GO:0034220	biolink:BiologicalProcess	ion transmembrane transport	A process in which an ion is transported across a membrane.		hp.json	ATP hydrolysis coupled ion transmembrane transport|transmembrane ion transport|ion membrane transport	http://purl.obolibrary.org/obo/GO_0034220		
HP:0006406	biolink:PhenotypicFeature	Club-shaped proximal femur	An abnormal conformation of the femur that becomes gradually enlarged towards the proximal end. This feature affects the proximal femoral metaphysis and epiphysis.	UMLS:C1968611	hp.json	Club-shaped innermost end of thighbone	http://purl.obolibrary.org/obo/HP_0006406		
GO:1900193	biolink:BiologicalProcess	regulation of oocyte maturation	Any process that modulates the frequency, rate or extent of oocyte maturation.		hp.json		http://purl.obolibrary.org/obo/GO_1900193		
HP:0006407	biolink:PhenotypicFeature	Irregular distal femoral epiphysis	Anomaly of the contour of the Distal epiphysis of femur such that its normally smooth appearance is irregular.	UMLS:C4025050	hp.json	Irregular outermost thighbone end part	http://purl.obolibrary.org/obo/HP_0006407		
GO:1900195	biolink:BiologicalProcess	positive regulation of oocyte maturation	Any process that activates or increases the frequency, rate or extent of oocyte maturation.		hp.json	up-regulation of oocyte maturation|up regulation of oocyte maturation|activation of oocyte maturation|upregulation of oocyte maturation	http://purl.obolibrary.org/obo/GO_1900195		
HP:0006408	biolink:PhenotypicFeature	Distal tapering femur		UMLS:C4025049	hp.json	Tapering of outermost end of thighbone	http://purl.obolibrary.org/obo/HP_0006408		
HP:0006402	biolink:PhenotypicFeature	Distal shortening of limbs		UMLS:C1840307	hp.json	Short outer part of limbs	http://purl.obolibrary.org/obo/HP_0006402		
HP:0006400	biolink:PhenotypicFeature	Absent knee epiphyses		UMLS:C1859462	hp.json	Absent knee end part	http://purl.obolibrary.org/obo/HP_0006400		
GO:0048863	biolink:BiologicalProcess	stem cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.	Wikipedia:Stem_cell_differentiation	hp.json		http://purl.obolibrary.org/obo/GO_0048863		
GO:0048864	biolink:BiologicalProcess	stem cell development	The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0048864		
CHEBI:25978	biolink:ChemicalSubstance	phenylacetic acids	Any monocarboxylic acid that is phenylacetic acid or its substituted derivatives.		hp.json		http://purl.obolibrary.org/obo/CHEBI_25978		3_STAR
UBERON:0012167	biolink:AnatomicalEntity	buccal fat pad	The Buccal fat pad is one of several encapsulated fat masses in the cheek. It is a deep fat pad located on either side of the face between the buccinator muscle and several more superficial muscles. It should not be confused with the malar fat pad, which is directly below the skin of the cheek. It should also not be confused with jowl fat pads. It is implicated in the formation of hollow cheeks and the nasolabial fold, but not in the formation of jowls.	FMA:59799	hp.json	Bichat's fat pad|cheek fat pad	http://purl.obolibrary.org/obo/UBERON_0012167		
UBERON:0012168	biolink:AnatomicalEntity	umbilical cord blood	Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP].	MESH:D005312|CALOHA:TS-1079|BTO:0004053|EFO:0001942	hp.json	fetal blood|umbilical cord blood|cord blood	http://purl.obolibrary.org/obo/UBERON_0012168		efo_slim
GO:0048860	biolink:BiologicalProcess	glioblast division	The process resulting in the physical partitioning and separation of a glioblast into daughter cells.		hp.json		http://purl.obolibrary.org/obo/GO_0048860		
GO:0061844	biolink:BiologicalProcess	antimicrobial humoral immune response mediated by antimicrobial peptide	An immune response against microbes mediated by anti-microbial peptides in body fluid.		hp.json	peptide-mediated antimicrobial humoral response|antimicrobial peptide-mediated antimicrobial humoral response	http://purl.obolibrary.org/obo/GO_0061844		
GO:0048869	biolink:BiologicalProcess	cellular developmental process	A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.		hp.json		http://purl.obolibrary.org/obo/GO_0048869		
NCBITaxon:34346	biolink:OrganismalEntity	Schizosaccharomycetales		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_34346		
GO:0048872	biolink:BiologicalProcess	homeostasis of number of cells	Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.		hp.json	homeostasis of cell number|cell population homeostasis	http://purl.obolibrary.org/obo/GO_0048872		
CHEBI:25985	biolink:ChemicalSubstance	phenylalanine derivative	An amino acid derivative resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of phenylalanine  by a heteroatom. The definition normally excludes peptides containing phenylalanine  residues.		hp.json		http://purl.obolibrary.org/obo/CHEBI_25985		3_STAR
GO:0048873	biolink:BiologicalProcess	homeostasis of number of cells within a tissue	Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0048873		
UBERON:0012152	biolink:AnatomicalEntity	skeleton of pedal digitopodium	A subdivision of the pes skeleton consisting of both pedal acropodial skeleton and metatarsal skeleton, but excluding the tarsal skeleton.		hp.json	pedal digitopodium	http://purl.obolibrary.org/obo/UBERON_0012152		
UBERON:0012151	biolink:AnatomicalEntity	skeleton of manual digitopodium	A subdivision of the manus skeleton consisting of both manual acropodial skeleton and metacarpal skeleton, but excluding the carpal skeleton.		hp.json	manual digitopodium	http://purl.obolibrary.org/obo/UBERON_0012151		
UBERON:0012150	biolink:AnatomicalEntity	skeleton of digitopodium	A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton.		hp.json	digitopodium|skeleton of digits	http://purl.obolibrary.org/obo/UBERON_0012150		
CHEBI:23324	biolink:ChemicalSubstance	citrullines			hp.json		http://purl.obolibrary.org/obo/CHEBI_23324		1_STAR
GO:0048878	biolink:BiologicalProcess	chemical homeostasis	Any biological process involved in the maintenance of an internal steady state of a chemical.		hp.json		http://purl.obolibrary.org/obo/GO_0048878		goslim_drosophila
UBERON:0036146	biolink:AnatomicalEntity	cardiopharyngeal field	An region of the mesoderm that includes anterior lateral mesoderm of the first heart field plus contiguous pharyngeal mesoderm that gives rise to second-heart-field-derived regions of the heart and branchiomeric muscles.		hp.json		http://purl.obolibrary.org/obo/UBERON_0036146		
GO:0048870	biolink:BiologicalProcess	cell motility	Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.		hp.json	cell locomotion|movement of a cell|cell movement	http://purl.obolibrary.org/obo/GO_0048870		goslim_chembl|goslim_drosophila|goslim_generic|prokaryote_subset
GO:0048871	biolink:BiologicalProcess	multicellular organismal homeostasis	Any process involved in the maintenance of an internal steady state at the level of the multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0048871		
UBERON:0000170	biolink:AnatomicalEntity	pair of lungs	The pair of anatomical structures comprised of a left lung and right lung.	OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA|FMA:68877	hp.json	lungs|lungs pair|set of lungs|pulmones	http://purl.obolibrary.org/obo/UBERON_0000170		pheno_slim
UBERON:0000171	biolink:AnatomicalEntity	respiration organ	Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.	TGMA:0001247|SCTID:272626006|EMAPA:17607|SPD:0000428	hp.json	breathing organ|organ of apparatus respiratorius|organ of respiratory system|apparatus respiratorius organ|respiratory organ|gas exchange organ|respiratory system organ	http://purl.obolibrary.org/obo/UBERON_0000171		organ_slim|functional_classification
CHEBI:37962	biolink:ChemicalSubstance	adrenergic agent	Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.		hp.json	adrenergic agents|adrenergic drugs|adrenergics|adrenergic neuron agents|adrenergic drug	http://purl.obolibrary.org/obo/CHEBI_37962		3_STAR
UBERON:0000173	biolink:AnatomicalEntity	amniotic fluid	Amniotic fluid is a bodily fluid consisting of watery liquid surrounding and cushioning a growing fetus within the amnion. It allows the fetus to move freely without the walls of the uterus being too tight against its body. Buoyancy is also provided. The composition of the fluid changes over the course of gestation. Initially, amniotic fluid is similar to maternal plasma, mainly water with electrolytes. As the fetus develops, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid.	VHOG:0001267|CALOHA:TS-0034|EMAPA:36771|UMLS:C0002638|MESH:D000653|MA:0002893|ENVO:02000021|EV:0100123|FMA:305905|NCIT:C13188|BTO:0000068|GAID:1155	hp.json	liquor amnii|acqua amnii	http://purl.obolibrary.org/obo/UBERON_0000173		pheno_slim
GO:0046219	biolink:BiologicalProcess	indolalkylamine biosynthetic process	The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group.		hp.json	indolalkylamine anabolism|indolalkylamine synthesis|indolalkylamine biosynthesis|indolalkylamine formation	http://purl.obolibrary.org/obo/GO_0046219		
UBERON:0000178	biolink:AnatomicalEntity	blood	A fluid that is composed of blood plasma and erythrocytes.	FMA:9670|UMLS:C0005767|VHOG:0000224|BTO:0000089|GAID:965|EFO:0000296|OpenCyc:Mx4rvVjI8JwpEbGdrcN5Y29ycA|ZFA:0000007|EHDAA:418|CALOHA:TS-0079|MESH:D001769|TAO:0000007|XAO:0000124|ENVO:02000027|MA:0000059|EMAPA:16332|NCIT:C12434|galen:Blood|EV:0100047|MIAA:0000315|AAO:0000046|Wikipedia:Blood|EHDAA2:0000176	hp.json	vertebrate blood|portion of blood|whole blood	http://purl.obolibrary.org/obo/UBERON_0000178		efo_slim|human_reference_atlas|uberon_slim|vertebrate_core|pheno_slim
UBERON:0000179	biolink:AnatomicalEntity	haemolymphatic fluid	Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs.	CARO:0000081	hp.json	blood or blood analog|circulating fluid	http://purl.obolibrary.org/obo/UBERON_0000179		
UBERON:0000174	biolink:AnatomicalEntity	excreta	A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity.	BTO:0000491|AEO:0000184|EHDAA2_RETIRED:0003184|ENVO:02000022|FMA:9674|galen:Excretion	hp.json	excretion|excreted substance|waste substance|portion of excreted substance	http://purl.obolibrary.org/obo/UBERON_0000174		
UBERON:0036150	biolink:AnatomicalEntity	skin appendage follicle	An organ subunit in the skin that gives rise to cutaneous appendage.		hp.json	follicle|cutaneous appendage follicle|skin follicle	http://purl.obolibrary.org/obo/UBERON_0036150		
UBERON:0012141	biolink:AnatomicalEntity	manual digitopodium region	A digitopodium region that is part of a manus[Obol]. This includes the fingers and metacarpal region, but excludes the carpal region.		hp.json		http://purl.obolibrary.org/obo/UBERON_0012141		
UBERON:0012140	biolink:AnatomicalEntity	digitopodium region	A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region.		hp.json	acropodium (Wagner)	http://purl.obolibrary.org/obo/UBERON_0012140		
CHEBI:50910	biolink:ChemicalSubstance	neurotoxin	A poison that interferes with the functions of the nervous system.	Wikipedia:Neurotoxin	hp.json	neurotoxic agents|neurotoxic agent|nerve poison|neurotoxins|neurotoxicant|nerve poisons|agente neurotoxico	http://purl.obolibrary.org/obo/CHEBI_50910		3_STAR
UBERON:0012142	biolink:AnatomicalEntity	pedal digitopodium region	A digitopodium region that is part of a pes[Obol]. This includes the toes and metatarsal region, but excludes the tarsals region.		hp.json		http://purl.obolibrary.org/obo/UBERON_0012142		
GO:0048880	biolink:BiologicalProcess	sensory system development	The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure.		hp.json		http://purl.obolibrary.org/obo/GO_0048880		
UBERON:0000160	biolink:AnatomicalEntity	intestine	Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine.	XAO:0000129|MESH:D007422|MA:0000328|ZFA:0001338|MIAA:0000043|VHOG:0000056|EV:0100071|BSA:0000093|WBbt:0005772|NCIT:C12736|MA:0001524|TAO:0001338|BTO:0000648|EFO:0000834|UMLS:C0021853|galen:Intestine|FMA:7199|CALOHA:TS-0490|SCTID:256876008|AAO:0000246|GAID:295|EMAPA:32874|ANISEED:1235303|Wikipedia:Intestine	hp.json	intestinal tract|bowel	http://purl.obolibrary.org/obo/UBERON_0000160		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0000161	biolink:AnatomicalEntity	orifice	Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified].	SCTID:91837002|FMA:3724	hp.json	ostium|anatomical ostium|anatomical orifice|hilum	http://purl.obolibrary.org/obo/UBERON_0000161		
UBERON:0000162	biolink:AnatomicalEntity	cloaca	Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures.	AAO:0000095|SCTID:362857006|XAO:0000244|MESH:D002988|VHOG:0001186|SCTID:370631000|Wikipedia:Cloaca|NCIT:C34127|GAID:1206|UMLS:C0008987|ZFA:0005781	hp.json	vent|cloacal chamber	http://purl.obolibrary.org/obo/UBERON_0000162		
UBERON:0012139	biolink:AnatomicalEntity	segment of autopod			hp.json		http://purl.obolibrary.org/obo/UBERON_0012139		
UBERON:0000167	biolink:AnatomicalEntity	oral cavity	Anatomical cavity at the start of the digestive tract that that is enclosed by the mouth. The boundaries and contents vary depending on the species. In vertebrates, the boundaries are the oral opening, the cheeks, the palate and (if present) the palatoglossal arch - if this is not present then the mouth and pharynx form the oropharyngeal cavity. The buccal cavity contains the teeth, tongue and palate (when present).	AAO:0000960|EV:0100057|EHDAA:6970|UMLS:C0226896|HAO:0000669|CALOHA:TS-1315|AAO:0000053|SCTID:181220002|XAO:0000126|VHOG:0000188|TGMA:0000102|WBbt:0005255|ZFA:0001027|EMAPA:17411|BSA:0000107|FMA:20292|EMAPA:18399|TAO:0001027|EHDAA2:0001324|EFO:0001975|NCIT:C12421	hp.json	bucca|cavity of mouth|buccal cavity	http://purl.obolibrary.org/obo/UBERON_0000167		pheno_slim|uberon_slim|vertebrate_core
UBERON:0000168	biolink:AnatomicalEntity	proximal-distal subdivision of colon	A section dividing a colon along a proximal-distal axis.	FMA:222905	hp.json	segment of colon	http://purl.obolibrary.org/obo/UBERON_0000168		non_informative
UBERON:0000163	biolink:AnatomicalEntity	embryonic cloaca	Endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP].	Wikipedia:Cloaca_(embryology)|EMAPA:27573|EHDAA2:0000256|EHDAA:4895	hp.json	cloaca	http://purl.obolibrary.org/obo/UBERON_0000163		pheno_slim
UBERON:0000164	biolink:AnatomicalEntity	primitive urogenital sinus	The ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females.	EHDAA:5919|EMAPA:17379|EHDAA2:0004060|EHDAA:5029|UMLS:C0231057|NCIT:C34322|VHOG:0000414	hp.json	fetal UGS|UGS|urogenital sinus|sinus urogenitalis	http://purl.obolibrary.org/obo/UBERON_0000164		pheno_slim
UBERON:0000165	biolink:AnatomicalEntity	mouth	The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks).	MIAA:0000038|ZFA:0000590|SCTID:21082005|TAO:0000590|Wikipedia:Mouth|CALOHA:TS-1315|BTO:0004698|ZFA:0000547|GAID:75|TAO:0000547|XAO:0003029|EFO:0000825|FBbt:00003126|TADS:0000040|MESH:D009055|EHDAA2:0001326|TGMA:0000131|MAT:0000038|OpenCyc:Mx4rvVidh5wpEbGdrcN5Y29ycA|MA:0000341|VHOG:0000280|http://purl.obolibrary.org/obo/uberon/images/lamprey_sucker_rosava_3238889218.jpg|EHDAA:542|VHOG:0000812|EMAPA:16262|AAO:0010355|BTO:0001090|MA:0002474|FMA:49184|galen:Mouth	hp.json	trophic apparatus|oral vestibule|stomatodaeum|adult mouth|trophic apparatus|rima oris|cavital oralis|oral region|cavital oralis|mouth cavity|cavum oris|regio oralis|vestibule of mouth|stoma|regio oralis|cavitas oris|vestibulum oris	http://purl.obolibrary.org/obo/UBERON_0000165		efo_slim|uberon_slim|major_organ|vertebrate_core|pheno_slim
UBERON:0000166	biolink:AnatomicalEntity	oral opening	The orifice that connects the mouth to the exterior of the body.	FMA:59806	hp.json	oral part of face|oral orifice|mouth|oral fissure	http://purl.obolibrary.org/obo/UBERON_0000166		uberon_slim|vertebrate_core
UBERON:0014790	biolink:AnatomicalEntity	lingual septum	The lingual septum consists of a vertical layer of fibrous tissue, extending throughout the entire length of the median plane of the tongue, though not quite reaching the dorsum. It is thicker behind than in front, and occasionally contains a small fibrocartilage, about 6 mm. in length. It is well displayed by making a vertical section across the organ.	Wikipedia:Lingual_septum|SCTID:368727001|FMA:54813|EMAPA:18274	hp.json	septum of tongue|septum of tongue|tongue septum|median fibrous septum|septum of tongue|median fibrous septum|tongue septum	http://purl.obolibrary.org/obo/UBERON_0014790		
OBO:uberon/core#site_of	biolink:NamedThing	site_of	c site_of p if c is the bearer of a disposition that is realized by a process that has p as part.		hp.json	capable_of_has_part	http://purl.obolibrary.org/obo/uberon/core#site_of		
UBERON:0014791	biolink:AnatomicalEntity	musculature of forelimb stylopod	Any collection of muscles that is part of the forelimb stylopod region [Automatically generated definition].	FMA:50202	hp.json	arm musculature|musculature of arm|set of muscles of arm|muscle group of arm	http://purl.obolibrary.org/obo/UBERON_0014791		
UBERON:0014792	biolink:AnatomicalEntity	musculature of pelvic complex	Any collection of muscles that is part of a pelvic complex. The pelvic complex comprises the pelvic girdle and the associated limb or fin.	FMA:71297|EMAPA:37864	hp.json	musculi membri inferioris|musculature of lower limb|muscles of lower limb	http://purl.obolibrary.org/obo/UBERON_0014792		
CHEBI:50904	biolink:ChemicalSubstance	allergen	A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy.	Wikipedia:Allergen	hp.json	allergene|allergenic agent|alergeno	http://purl.obolibrary.org/obo/CHEBI_50904		3_STAR
CHEBI:50903	biolink:ChemicalSubstance	carcinogenic agent	A role played by a chemical compound which is known to  induce a process of carcinogenesis  by corrupting  normal cellular pathways, leading to the acquistion of tumoral capabilities.		hp.json	carcinogen|cancerogene|carcinogene|carcinogenic agents|cancerigene|carcinogens|agente carcinogeno|carcinogeno	http://purl.obolibrary.org/obo/CHEBI_50903		3_STAR
UBERON:0012131	biolink:AnatomicalEntity	centrale	Endochondral bone located between the proximal and distal rows of carpals or tarsals and thus representing the central carpals or tarsals[PHENOSCAPE].	EMAPA:36170|FMA:77232	hp.json	central mesopodium bone|centralia|os centrale	http://purl.obolibrary.org/obo/UBERON_0012131		
UBERON:0014793	biolink:AnatomicalEntity	musculature of pectoral complex	Any collection of muscles that is part of a pectoral complex. The pectoral complex comprises the pectoral girdle and the associated limb or fin.	FMA:71296|EMAPA:37861	hp.json	upper limb musculature|set of muscles of upper limb|musculature of upper limb|muscles of upper limb|musculi membri superioris	http://purl.obolibrary.org/obo/UBERON_0014793		
UBERON:0014794	biolink:AnatomicalEntity	pectoral appendage muscle	Any muscle organ that is part of a pectoral appendage (forelimb or pectoral fin).		hp.json		http://purl.obolibrary.org/obo/UBERON_0014794		
UBERON:0014795	biolink:AnatomicalEntity	pelvic appendage muscle	Any muscle organ that is part of a pelvic appendage (hindlimb or pelvic fin).		hp.json		http://purl.obolibrary.org/obo/UBERON_0014795		
UBERON:0014796	biolink:AnatomicalEntity	common tendinous ring	A ring of fibrous tissue surrounding the optic nerve at its entrance at the apex of the orbit.	FMA:49071	hp.json	anulus tendineus|common anular tendon|anulus tendineus communis|anulus of Zinn|common tendinous ring|annulus tendineus communis|common annular tendon|annulus of Zinn|tendon of Zinn|ligament of Zinn|anulus tendineus communis	http://purl.obolibrary.org/obo/UBERON_0014796		
CHEBI:50906	biolink:ChemicalSubstance	role	A role is particular behaviour which a material entity may exhibit.		hp.json		http://purl.obolibrary.org/obo/CHEBI_50906		3_STAR
UBERON:0012128	biolink:AnatomicalEntity	nose tip	Outermost point on an external nose or snout.	FMA:59518|EMAPA:37915	hp.json	pirula|tip of snout|snout tip|apex of nose|apex nasi|tip of nose|nasal tip	http://purl.obolibrary.org/obo/UBERON_0012128		pheno_slim
GO:0061854	biolink:BiologicalProcess	positive regulation of neuroblast migration	Any process that activates or increases the frequency, rate or extent of neuroblast migration.		hp.json		http://purl.obolibrary.org/obo/GO_0061854		
GO:0061853	biolink:BiologicalProcess	regulation of neuroblast migration	Any process that modulates the frequency, rate or extent of neuroblast migration.		hp.json		http://purl.obolibrary.org/obo/GO_0061853		
GO:0061855	biolink:BiologicalProcess	negative regulation of neuroblast migration	Any process that stops, prevents, or reduces the frequency, rate or extent of neuroblast migration.		hp.json		http://purl.obolibrary.org/obo/GO_0061855		
UBERON:0000158	biolink:AnatomicalEntity	membranous layer		FMA:30322|MESH:D008566|NCIT:C12749|FMA:82500	hp.json	membrane|membranous organ component	http://purl.obolibrary.org/obo/UBERON_0000158		
UBERON:0000159	biolink:AnatomicalEntity	anal canal	The terminal part of the large intestine, continuous proximally with the rectum and distally terminates with the anus.	MA:0000330|MESH:D001003|SCTID:245438008|Wikipedia:Anal_canal|CALOHA:TS-2160|NCIT:C12375|FMA:15703|galen:AnalCanal|UMLS:C0227411|EMAPA:18256|BTO:0001978	hp.json	cloacal chamber|canalis analis|mesenteron|pars analis recti|anus|anal pad|cloaca|anal canal|anatomical anal canal|anal canal viewed anatomically|canalis analis|canalis analis	http://purl.obolibrary.org/obo/UBERON_0000159		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0000153	biolink:AnatomicalEntity	anterior region of body			hp.json		http://purl.obolibrary.org/obo/UBERON_0000153		
UBERON:0000154	biolink:AnatomicalEntity	posterior region of body			hp.json		http://purl.obolibrary.org/obo/UBERON_0000154		
GO:1902738	biolink:BiologicalProcess	regulation of chondrocyte differentiation involved in endochondral bone morphogenesis	Any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.		hp.json		http://purl.obolibrary.org/obo/GO_1902738		
CHEBI:13941	biolink:ChemicalSubstance	carbamate		Gmelin:239604|Beilstein:3903503|CAS:302-11-4	hp.json	carbamate|Karbamat|carbamate ion|carbamic acid, ion(1-)|carbamate|Carbamat	http://purl.obolibrary.org/obo/CHEBI_13941		3_STAR
UBERON:0012193	biolink:AnatomicalEntity	phrenic vein	The veins that run parallel to the phrenic arteries which include the two superior and two inferior phrenic veins.	EMAPA:37180|NCIT:C53062|UMLS:C1709532|MA:0002194	hp.json		http://purl.obolibrary.org/obo/UBERON_0012193		
UBERON:0012198	biolink:AnatomicalEntity	intercostal space	A space in the rib cage between two successive ribs.	FMA:12243	hp.json		http://purl.obolibrary.org/obo/UBERON_0012198		
GO:1902742	biolink:BiologicalProcess	apoptotic process involved in development	Any apoptotic process that is involved in anatomical structure development.		hp.json	apoptosis signaling involved in anatomical structure development|programmed cell death by apoptosis involved in development of an anatomical structure|type I programmed cell death involved in development of an anatomical structure|apoptosis involved in development of an anatomical structure|apoptosis activator activity involved in development of an anatomical structure|induction of apoptosis involved in development of an anatomical structure|commitment to apoptosis involved in development of an anatomical structure|activation of apoptosis involved in development of an anatomical structure|programmed cell death by apoptosis involved in anatomical structure development|type I programmed cell death involved in anatomical structure development|signaling (initiator) caspase activity involved in development of an anatomical structure|apoptosis activator activity involved in anatomical structure development|commitment to apoptosis involved in anatomical structure development|apoptosis involved in anatomical structure development|induction of apoptosis involved in anatomical structure development|apoptotic programmed cell death involved in development of an anatomical structure|apoptotic program involved in development of an anatomical structure|induction of apoptosis by p53 involved in development of an anatomical structure|apoptotic process involved in development of an anatomical structure|activation of apoptosis involved in anatomical structure development|apoptotic cell death involved in development of an anatomical structure|signaling (initiator) caspase activity involved in anatomical structure development|apoptotic programmed cell death involved in anatomical structure development|apoptotic program involved in anatomical structure development|induction of apoptosis by p53 involved in anatomical structure development|apoptotic cell death involved in anatomical structure development|apoptosis signaling involved in development of an anatomical structure|apoptotic process involved in anatomical structure development	http://purl.obolibrary.org/obo/GO_1902742		
UBERON:0012197	biolink:AnatomicalEntity	intercostal vein	The intercostal veins are a group of veins which drain the area between the ribs.	EMAPA:18762|MA:0003166	hp.json		http://purl.obolibrary.org/obo/UBERON_0012197		
PATO:0000297	biolink:NamedThing	arrested	A quality of a process which ends earlier than the natural end time or reference process.		hp.json	incomplete|abolished	http://purl.obolibrary.org/obo/PATO_0000297		value_slim
PATO:0000299	biolink:NamedThing	mobile	A mobility quality of inhering in a bearer by virtue of the bearer's disposition to move freely.		hp.json		http://purl.obolibrary.org/obo/PATO_0000299		disposition_slim|value_slim
UBERON:0012180	biolink:AnatomicalEntity	head or neck skin	A zone of skin that is part of a craniocervical region.	MA:0000574|UMLS:C1522650|EMAPA:37276|NCIT:C12294	hp.json		http://purl.obolibrary.org/obo/UBERON_0012180		
PR:P19437	biolink:Protein	B-lymphocyte antigen CD20 (mouse)	A membrane-spanning 4-domains subfamily A member 1 that is encoded in the genome of mouse.	UniProtKB:P19437	hp.json	lymphocyte antigen 44 (mouse)|mMS4A1|B-cell differentiation antigen Ly-44 (mouse)|CD20 (mouse)|Ly-44|membrane-spanning 4-domains subfamily A member 1 (mouse)|Cd20|Ms4a2|Ms4a1	http://purl.obolibrary.org/obo/PR_P19437		
UBERON:0012172	biolink:AnatomicalEntity	stomach primordium	A primordium that has the potential to develop into a stomach.	EFO:0002580|NCIT:C34305|UMLS:C1514976	hp.json	stomach endoderm	http://purl.obolibrary.org/obo/UBERON_0012172		efo_slim
UBERON:0012177	biolink:AnatomicalEntity	skin apocrine gland	An apocrine gland that is part of a skin of body.	MA:0000147	hp.json		http://purl.obolibrary.org/obo/UBERON_0012177		
UBERON:0012175	biolink:AnatomicalEntity	acoustico-facial VII-VIII ganglion complex		EMAPA:16794|VHOG:0000715|EHDAA2:0000494	hp.json	facio-acoustic ganglion complex VII-VIII|facio-acoustic ganglion|facio-acoustic ganglion complex|facio-acoustic VII-VIII ganglion complex|acousticofacial ganglion	http://purl.obolibrary.org/obo/UBERON_0012175		
GO:1902761	biolink:BiologicalProcess	positive regulation of chondrocyte development	Any process that activates or increases the frequency, rate or extent of chondrocyte development.		hp.json	up-regulation of chondrocyte development|up regulation of chondrocyte development|activation of chondrocyte development|upregulation of chondrocyte development	http://purl.obolibrary.org/obo/GO_1902761		
UBERON:0000199	biolink:AnatomicalEntity	neck of radius	The narrow part of the shaft of the radius just below the head.	galen:NeckOfRadius|FMA:23479	hp.json	collum radii|radial neck	http://purl.obolibrary.org/obo/UBERON_0000199		pheno_slim
HP:0006180	biolink:PhenotypicFeature	Crowded carpal bones		UMLS:C1863317	hp.json	Crowded wrist bones	http://purl.obolibrary.org/obo/HP_0006180		
HP:0031144	biolink:PhenotypicFeature	Coarsened hepatic echotexture	The appearance of the liver in sonographic images is normally uniform. This term applies when there is an irregular or non-uniform appearance of the liver parenchyma in liver sonography.		hp.json		http://purl.obolibrary.org/obo/HP_0031144		
HP:0031145	biolink:PhenotypicFeature	Starry sky appearance on hepatic sonography	An abnormal echotexture visible in liver ultrasound manifesting as a diffuse hyperechoic liver echotexture with multiple, small hypoechoic lesions. The appearance is said to resemble a starry sky (multiple white spots on a dark background).		hp.json		http://purl.obolibrary.org/obo/HP_0031145		
HP:0031146	biolink:PhenotypicFeature	Impaired oral bolus formation	An abnormality of swallowing characterized by reduced tongue coordination to form bolus after chewing. Food material spreads over the oral cavity instead of being concentrated into a bolus that is easily swallowed.		hp.json		http://purl.obolibrary.org/obo/HP_0031146		
HP:0031140	biolink:PhenotypicFeature	Abnormal liver sonography	An abnormal appearance of the liver or any of its components on sonography (ultrasound).		hp.json		http://purl.obolibrary.org/obo/HP_0031140		
HP:0031141	biolink:PhenotypicFeature	Increased hepatic echogenicity	Increased echogenicity of liver tissue on sonography, manifested as an increased amount of white on the screen of the sonography device.		hp.json	Hyperechogenic liver	http://purl.obolibrary.org/obo/HP_0031141		
HP:0031142	biolink:PhenotypicFeature	Abnormal hepatic echogenicity	Any deviation from the normal degree of echogenicity of the liver on sonography. Echogenicity refers to the ability of a tissue to reflect or transmit ultrasound waves in the context of surrounding tissues. Whenever there is an interface of structures with different echogenicities, a visible difference in contrast will be apparent on the screen. Based on echogenicity, a structure can be characterized as hyperechoic (white on the screen), hypoechoic (gray on the screen) and anechoic (black on the screen).		hp.json		http://purl.obolibrary.org/obo/HP_0031142		
HP:0031143	biolink:PhenotypicFeature	Decreased hepatic echogenicity	Reduced echogenicity of liver tissue on sonography, manifested as an increased amount of black on the screen of the sonography device.		hp.json	Hypoechogenic liver	http://purl.obolibrary.org/obo/HP_0031143		
UBERON:0002401	biolink:AnatomicalEntity	visceral pleura	The inner serous membrane of the pulmonary pleural. The visceral pleura lines the lungs.	NCIT:C33881|OpenCyc:Mx4rwNFqppwpEbGdrcN5Y29ycA|SCTID:361997008|EMAPA:16777|VHOG:0001496|FMA:9734|UMLS:C0225776|MA:0002489|EHDAA2:0002205	hp.json	pleura visceralis (pulmonalis)|pleura visceralis|pleura pulmonalis|lung mesothelium|lung pleura|pulmonary pleura|pleura visceralis|pulmonary visceral pleura	http://purl.obolibrary.org/obo/UBERON_0002401		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0002400	biolink:AnatomicalEntity	parietal pleura	The outer serous membrane of the pulmonary pleural.	OpenCyc:Mx4rvv2Uq5wpEbGdrcN5Y29ycA|UMLS:C0225777|NCIT:C33273|Wikipedia:Parietal_pleura|EMAPA:16776|VHOG:0001495|FMA:9733|SCTID:361998003|MA:0002488	hp.json	pleura parietalis|pleura parietalis	http://purl.obolibrary.org/obo/UBERON_0002400		pheno_slim|uberon_slim
GO:0009416	biolink:BiologicalProcess	response to light stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.		hp.json		http://purl.obolibrary.org/obo/GO_0009416		goslim_plant
HP:0006179	biolink:PhenotypicFeature	Pseudoepiphyses of second metacarpal		UMLS:C1862693	hp.json	Pseudoepiphysis of the 2nd metacarpal|Extra bone on end of second long bone of hand	http://purl.obolibrary.org/obo/HP_0006179		
UBERON:0002402	biolink:AnatomicalEntity	pleural cavity	The fluid-filled cavity that lies between the visceral and parietal pleurae.	NCIT:C12840|MA:0000055|FMA:9740|UMLS:C0178802|MESH:D035422|EHDAA2:0001475|Wikipedia:Pleural_cavity|OpenCyc:Mx4rwCKAppwpEbGdrcN5Y29ycA|BTO:0004422|GAID:95|SCTID:361999006|EMAPA:16774|VHOG:0000581|EMAPA:16773	hp.json	cavitas pleuralis|cavitum pleurale|cavitum pleuralae|cavitas pleuralis|cavitum pleuralae|cavitum pleurale	http://purl.obolibrary.org/obo/UBERON_0002402		pheno_slim|uberon_slim
CHEBI:59226	biolink:ChemicalSubstance	N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose	An amino trisaccharide that is the carbohydrate portion of ganglioside GM3. It comprises a linear sequence of alpha-N-acetylneuraminyl, beta-D-galactosyl and beta-D-glucose residues linked (2->3) and (1->4).	PMID:3768140|PMID:6672002|GlyGen:G91237TK|PMID:14613940|PMID:12950597|PMID:7507746|PMID:25568069|PMID:3142362|PMID:15179041|PMID:24027187|PMID:599156|Reaxys:4632263|PMID:7706301|Beilstein:4632263|PMID:11164910|PMID:510308|HMDB:HMDB0000825|PMID:31537530|PMID:12058986|PMID:33164488|PMID:19443021|GlyTouCan:G91237TK	hp.json	3'-(N-Acetyl-a-neuraminosyl)lactose|(2->3')-alpha-Sialyllactose|alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp|WURCS=2.0/3,3,2/[a2122h-1b_1-5][a2112h-1b_1-5][Aad21122h-2a_2-6_5*NCC/3=O]/1-2-3/a4-b1_b3-c2|A2,3-Sialyllactose|3'-Sialyl-D-lactose|3'-a-Sialyllactose|Neu5Acalpha2-3Galbeta1-4Glcbeta|alpha-Neu5Ac-(2->3)-beta-delta-Gal-(1->4)-delta-Glc|N-Acetylneuraminoyllactose|(2S,4S,5R,6R)-2-{[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-{[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxy}oxan-4-yl]oxy}-5-acetamido-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid|3'-alpha-Sialyllactose|3'-sialyllactose|3'-N-Acetylneuraminyl-delta-lactose|(6R)-5-(acetylamino)-3,5-dideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-beta-L-threo-hex-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose|alpha-Neu5Ac-(2->3)-beta-D-Gal-(->4)-D-Glc|32-N-Acetyl-a-neuraminyllactose|5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose|3'-Monosialyllactose|a-Neu5Ac-(2->3)-b-D-Gal-(1->4)-D-Glc|GM3 carbohydrate moiety|alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose|3'-N-Acetylneuraminyl-D-lactose|3'-(N-Acetyl-alpha-neuraminosyl)lactose|(2->3')-a-Sialyllactose|Neu5Aca2-3Galb1-4Glcb|alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc|32-N-Acetyl-alpha-neuraminyllactose|N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose|3'-Sialyl-delta-lactose	http://purl.obolibrary.org/obo/CHEBI_59226		3_STAR
HP:0006174	biolink:PhenotypicFeature	Metacarpal diaphyseal endosteal sclerosis	Increase in bone density in the diaphyseal (shaft) region of a metacarpal bone.	UMLS:C1840419	hp.json		http://purl.obolibrary.org/obo/HP_0006174		
HP:0006175	biolink:PhenotypicFeature	Proximal phalangeal periosteal thickening		UMLS:C1834348|UMLS:C4280463	hp.json	Thickening of connective tissue of innermost finger bone	http://purl.obolibrary.org/obo/HP_0006175		
HP:0006176	biolink:PhenotypicFeature	Two carpal ossification centers present at birth		UMLS:C1839285	hp.json	Two carpal ossification centres present at birth	http://purl.obolibrary.org/obo/HP_0006176		
HP:0006191	biolink:PhenotypicFeature	Deep palmar crease	Excessively deep creases of the palm.	UMLS:C1857539	hp.json	Deep palmar creases|Deep palm line	http://purl.obolibrary.org/obo/HP_0006191		hposlim_core
HP:0006192	biolink:PhenotypicFeature	Tapered phalanx of finger	Phalanges of the fingers becoming thinner toward the distal end.	UMLS:C4025084	hp.json	Tapered finger bone	http://purl.obolibrary.org/obo/HP_0006192		
HP:0006193	biolink:PhenotypicFeature	Thimble-shaped middle phalanges of hand	The middle phalanx of finger resembles a thimble, a small metal cap to protect the finger while sewing that has a broad (proximal) base and narrower top, whereby both base and top are flat.	UMLS:C4025083	hp.json	Thimble-shaped middle bones of hand	http://purl.obolibrary.org/obo/HP_0006193		
HP:0031150	biolink:PhenotypicFeature	Vitreomacular adhesion	Perifoveal vitreous separation with remaining vitreomacular attachment and unperturbed foveal morphologic features. It is an OCT finding that is almost always the result of normal vitreous aging, which may lead to pathologic conditions.		hp.json	VMA	http://purl.obolibrary.org/obo/HP_0031150		
HP:0006190	biolink:PhenotypicFeature	Radially deviated wrists		UMLS:C1861316	hp.json		http://purl.obolibrary.org/obo/HP_0006190		
HP:0031155	biolink:PhenotypicFeature	Increased Arden ratio of electrooculogram	An abnormal increase in the Arden ratio, which is the ratio between the light peak and the dark trough of the smoothed (physiologic) EOG record.		hp.json	Increased Arden ratio of EOG	http://purl.obolibrary.org/obo/HP_0031155		
HP:0031156	biolink:PhenotypicFeature	Decreased platelet glycoprotein Ib	Decreased platelet cell membrane concentration of glycoprotein Ib.		hp.json		http://purl.obolibrary.org/obo/HP_0031156		
HP:0031157	biolink:PhenotypicFeature	Carotid cavernous fistula	An abnormal connection between a carotid artery and the cavernous sinus.		hp.json	Caroticocavernous fistula	http://purl.obolibrary.org/obo/HP_0031157		
HP:0031158	biolink:PhenotypicFeature	Widened atrophic scar	An atrophic scar (fibrous connective tissue resulting from incomplete healing of a wound) that has stretched (gotten wider), a manifestation of tissue fragility.		hp.json		http://purl.obolibrary.org/obo/HP_0031158		
HP:0031151	biolink:PhenotypicFeature	Vitreomacular traction	Vitreomacular traction is characterized by anomalous posterior vitreous detachment accompanied by anatomic distortion of the fovea, which may include pseudocysts, macular schisis, cystoid macular edema, and subretinal fluid. Vitreomacular traction can be subclassified by the diameter of vitreous attachment to the macular surface as measured by OCT, with attachment of 1500 micrometers or less defined as focal and attachment of more than 1500 micrometers as broad.		hp.json	VMT	http://purl.obolibrary.org/obo/HP_0031151		
HP:0031152	biolink:PhenotypicFeature	Full-thickness macular hole	Full-thickness macular hole (FTMH) is defined as a foveal lesion with interruption of all retinal layers from the internal limiting membrane to the retinal pigment epithelium. Full-thickness macular hole is primary if caused by vitreous traction or secondary if directly the result of pathologic characteristics other than vitreomacular traction. Full-thickness macular hole is subclassified by size of the hole as determined by OCT and the presence or absence of vitreomacular traction.		hp.json	FTMH	http://purl.obolibrary.org/obo/HP_0031152		
CHEBI:132939	biolink:ChemicalSubstance	ethylmalonate(2-)	A dicarboxylic acid dianion resulting from the removal of a proton from both of the carboxylic acid groups of ethylmalonic acid.	Reaxys:3904851	hp.json	ethylpropanedioate	http://purl.obolibrary.org/obo/CHEBI_132939		3_STAR
HP:0031153	biolink:PhenotypicFeature	Membranous vitreous appearance	Vitreous humor of the eye displaying consisting of a vestigial gel in the retrolental space bounded by a convoluted membrane.		hp.json	Membranous anomaly|Membranous vitreous|Membranous vitreous phenotype	http://purl.obolibrary.org/obo/HP_0031153		
CHEBI:132938	biolink:ChemicalSubstance	ethylmalonate	A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of ethylmalonic acid.		hp.json	ethylmalonic acid anion|ethylmalonate anion	http://purl.obolibrary.org/obo/CHEBI_132938		3_STAR
HP:0031154	biolink:PhenotypicFeature	Beaded vitreous appearance	Vitreous humor of the eye displaying beaded bundles of irregular diameters.		hp.json		http://purl.obolibrary.org/obo/HP_0031154		
CHEBI:35267	biolink:ChemicalSubstance	quaternary ammonium ion	A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually organyl) groups.	KEGG:C06703	hp.json	quaternary ammonium|quaternary ammonium ion|Quaternary amine|quaternary ammonium ions	http://purl.obolibrary.org/obo/CHEBI_35267		3_STAR
HP:0031159	biolink:PhenotypicFeature	Thinning of Descemet membrane	A reduction in the thickness of Descemet's membrane.		hp.json		http://purl.obolibrary.org/obo/HP_0031159		
HP:0006189	biolink:PhenotypicFeature	Prominent interdigital folds		UMLS:C1866000	hp.json		http://purl.obolibrary.org/obo/HP_0006189		
HP:0006184	biolink:PhenotypicFeature	Decreased palmar creases	Poorly defined or shallow palmar creases.	UMLS:C1857483	hp.json	Shallow palmar creases|Poorly formed palmar creases|Shallow palm line|Hypoplastic palmar creases	http://purl.obolibrary.org/obo/HP_0006184		hposlim_core
HP:0006185	biolink:PhenotypicFeature	Enlarged proximal interphalangeal joints		UMLS:C1861350	hp.json	Enlarged innermost hinge joint	http://purl.obolibrary.org/obo/HP_0006185		
HP:0006187	biolink:PhenotypicFeature	obsolete Fusion of midphalangeal joints			hp.json		http://purl.obolibrary.org/obo/HP_0006187		
HP:0006160	biolink:PhenotypicFeature	Irregular metacarpals	Irregular morphology of one or more metacarpal bones.	UMLS:C4025086	hp.json	Irregular long bones of hand	http://purl.obolibrary.org/obo/HP_0006160		
HP:0031160	biolink:PhenotypicFeature	Myelokathexis	Impaired egress of mature neutrophils from bone marrow causing neutropenia.		hp.json		http://purl.obolibrary.org/obo/HP_0031160		
HP:0031161	biolink:PhenotypicFeature	Reduced brain glutamate level by MRS	An decrease in the level of glutamate (Glu) in the brain identified by magnetic resonance spectroscopy (MRS).		hp.json		http://purl.obolibrary.org/obo/HP_0031161		
HP:0006161	biolink:PhenotypicFeature	Short metacarpals with rounded proximal ends		UMLS:C1856471	hp.json	Short long bone of hand with rounded innermost ends	http://purl.obolibrary.org/obo/HP_0006161		
HP:0031166	biolink:PhenotypicFeature	Eyelid myokymia	Involuntary, fine, continuous, undulating contractions of the eyelid.		hp.json	Myokymia orbicularis|Orbicularis myokymia	http://purl.obolibrary.org/obo/HP_0031166		
HP:0031167	biolink:PhenotypicFeature	Triggered by ingestion of potassium-rich food	Applies to a sign or symptom that is provoked or brought about by eating or drinking foods rich in potassium.		hp.json	Triggered by ingestion of K-rich food|Potassium-rich food triggered symptoms	http://purl.obolibrary.org/obo/HP_0031167		
HP:0031169	biolink:PhenotypicFeature	Postterm pregnancy	A pregnancy that extends to 42 weeks of gestation or beyond.		hp.json		http://purl.obolibrary.org/obo/HP_0031169		
HP:0031162	biolink:PhenotypicFeature	Impaired oropharyngeal swallow response	Delay or absence of the swallow response, reflexes triggered by the contact the food bolus makes with the anterior faucial pillars.		hp.json		http://purl.obolibrary.org/obo/HP_0031162		
HP:0031163	biolink:PhenotypicFeature	Low femoral bone density	Reduced bone mineral density of the femur.		hp.json	Low femur bone density	http://purl.obolibrary.org/obo/HP_0031163		
HP:0031164	biolink:PhenotypicFeature	Growth arrest lines	Growth arrest lines are alternating transverse rings of sclerosis at the metaphysis of a long bone.		hp.json	Growth resumption lines|Harris lines	http://purl.obolibrary.org/obo/HP_0031164		
HP:0031165	biolink:PhenotypicFeature	Multifocal seizures	Seizures that start from several different areas of the brain (i.e., with multiple ictal onset locations).		hp.json	Multifocal onset seizures	http://purl.obolibrary.org/obo/HP_0031165		
CHEBI:60242	biolink:ChemicalSubstance	monovalent inorganic cation	An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one.		hp.json	a monovalent cation	http://purl.obolibrary.org/obo/CHEBI_60242		3_STAR
CL:0002088	biolink:Cell	interstitial cell of Cajal	This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise.	FMA:86573|BTO:0003914	hp.json	intestinal pacemaker cell|ICC	http://purl.obolibrary.org/obo/CL_0002088		
HP:0006159	biolink:PhenotypicFeature	Mesoaxial hand polydactyly	The presence of a supernumerary finger (not a thumb) involving the third or fourth metacarpal with associated osseous syndactyly.	UMLS:C4021606	hp.json	Interdigital finger polydactyly|Central hand polydactyly	http://purl.obolibrary.org/obo/HP_0006159		hposlim_core
CHEBI:35238	biolink:ChemicalSubstance	amino acid zwitterion	The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group.		hp.json	amino acid zwitterion	http://purl.obolibrary.org/obo/CHEBI_35238		3_STAR
CHEBI:35237	biolink:ChemicalSubstance	cysteine zwitterion		Gmelin:49992	hp.json	(+)H3N-CH(CH2SH)-COO(-)|cysteine zwitterion|2-ammonio-3-mercaptopropanoate|2-ammonio-3-sulfanylpropanoate	http://purl.obolibrary.org/obo/CHEBI_35237		3_STAR
HP:0006155	biolink:PhenotypicFeature	Long phalanx of finger	Increased length of multiple or a single phalanx of finger.	UMLS:C4025087	hp.json	Long finger bone	http://purl.obolibrary.org/obo/HP_0006155		
HP:0006156	biolink:PhenotypicFeature	Ulnar deviation of thumb	Bending or curvature of a thumb towards the ulnar side (towards the ring finger).	SNOMEDCT_US:299137000|UMLS:C4280465|UMLS:C0575904	hp.json	Curved thumb deviated towards palm|Ulnar deviation of the 1st finger	http://purl.obolibrary.org/obo/HP_0006156		
CL:0002083	biolink:Cell	type I cell of adrenal medulla	A chromaffin cell of the adrenal medulla that produces norepinephrine.	FMA:69321	hp.json	noradrenergic chromaffin cell	http://purl.obolibrary.org/obo/CL_0002083		
HP:0006157	biolink:PhenotypicFeature	Prominent palmar flexion creases		UMLS:C4280464|UMLS:C1865131	hp.json	Prominent life line	http://purl.obolibrary.org/obo/HP_0006157		
CL:0002082	biolink:Cell	type II cell of adrenal medulla	A chromaffin cell of the adrenal medulla that produces epinephrine.	FMA:69322	hp.json	epiniphrine secreting cell of the adrenal medulla|adrenal secreting cell of the adrenal medulla|adremergic chromaffin cell	http://purl.obolibrary.org/obo/CL_0002082		
HP:0006158	biolink:PhenotypicFeature	obsolete Finger joint hyperextensibility			hp.json		http://purl.obolibrary.org/obo/HP_0006158		
HP:0006152	biolink:PhenotypicFeature	Proximal symphalangism of hands	The term proximal symphalangism refers to a bony fusion of the middle and proximal phalanges of the digits of the hand, in other words the proximal interphalangeal joint (PIJ) is missing which can be seen either on x-rays or as an absence of the proximal interphalangeal finger creases.	UMLS:C4021607	hp.json	Fused innermost hinge joints|Proximal interphalangeal joint synostoses	http://purl.obolibrary.org/obo/HP_0006152		
CHEBI:59203	biolink:ChemicalSubstance	straight-chain fatty acid anion	A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid.		hp.json	straight-chain FA anions|straight-chain FA anion|straight-chain fatty acid anions	http://purl.obolibrary.org/obo/CHEBI_59203		3_STAR
CL:0002087	biolink:Cell	nongranular leukocyte	A leukocyte that lacks granules.	FMA:62855	hp.json	agranular leukocyte	http://purl.obolibrary.org/obo/CL_0002087		
HP:0006153	biolink:PhenotypicFeature	Disharmonious carpal bone		UMLS:C2675549	hp.json	Disharmonious wrist bone	http://purl.obolibrary.org/obo/HP_0006153		
CL:0002086	biolink:Cell	specialized cardiac myocyte	A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart.	FMA:67968	hp.json		http://purl.obolibrary.org/obo/CL_0002086		
CHEBI:59202	biolink:ChemicalSubstance	straight-chain fatty acid	Any fatty acid whose skeletal carbon atoms form an unbranched open chain.		hp.json	straight-chain fatty acids	http://purl.obolibrary.org/obo/CHEBI_59202		3_STAR
HP:0031170	biolink:PhenotypicFeature	Female fetal virilization	Fetal masculinization of female external genitalia.		hp.json	Female foetal virilization	http://purl.obolibrary.org/obo/HP_0031170		
HP:0006170	biolink:PhenotypicFeature	Chess-pawn distal phalanges	A morphological abnormality of distal phalanges such that they have the appearance of chess pawns.	UMLS:C1862097	hp.json	Chess-pawn shaped outermost bone	http://purl.obolibrary.org/obo/HP_0006170		
HP:0031171	biolink:PhenotypicFeature	Femoral spur	A bony projection (spur, osteophyte) originating from the femur, often in the medial femoral neck.		hp.json	Spurring of femur	http://purl.obolibrary.org/obo/HP_0031171		
HP:0031172	biolink:PhenotypicFeature	Sectoral retinitis pigmentosa	A variant of retinitis pigmentosa in which there is a regional distribution of the retinal degeneration.		hp.json		http://purl.obolibrary.org/obo/HP_0031172		
HP:0006172	biolink:PhenotypicFeature	Flattened, squared-off epiphyses of tubular bones		UMLS:C1834961	hp.json	Flattened, squared-off end part of tubular bones	http://purl.obolibrary.org/obo/HP_0006172		
HP:0031177	biolink:PhenotypicFeature	Finger flexor weakness	Reduced ability to flex (bend) the fingers. This can manifest as incomplete closure of the hand due to weakness in finger flexion.		hp.json		http://purl.obolibrary.org/obo/HP_0031177		
HP:0031178	biolink:PhenotypicFeature	Fixed head retroflexion	Head is bent in the posterior direction in a permanent fashion.		hp.json		http://purl.obolibrary.org/obo/HP_0031178		
HP:0031179	biolink:PhenotypicFeature	Nuchal rigidity	Resistance of the extensor muscles of the neck to being bent forwards (i.e., impaired neck flexion) as a result of muscle spasm of the extensor muscles of the neck. Nuchal rigidity is not a fixed rigidity. Nuchal rigidity has been used as a bedside test for meningism, although its sensitivity for this purpose has been debated.		hp.json	Meningism	http://purl.obolibrary.org/obo/HP_0031179		
HP:0031173	biolink:PhenotypicFeature	Tibial spur	A bony projection (spur, osteophyte) originating from the tibia.		hp.json	Spurring of tibiae	http://purl.obolibrary.org/obo/HP_0031173		
HP:0031174	biolink:PhenotypicFeature	Double-layered patella	An anomaly of the patella characterized by two layers visible on lateral knee X-ray such that one layer is in front of the other in the sagittal orientation (See Figure 2A and 3B of PMID:12966518). This finding persists into adulthood.		hp.json		http://purl.obolibrary.org/obo/HP_0031174		
HP:0031175	biolink:PhenotypicFeature	Absent cervical vertebra	A developmental defect characterized by agenesis of one or more vertebral bodies of the cervical spine.		hp.json		http://purl.obolibrary.org/obo/HP_0031175		
HP:0031176	biolink:PhenotypicFeature	Absent thoracic vertebra	A developmental defect characterized by agenesis of one or more vertebral bodies of the thoracic spine.		hp.json		http://purl.obolibrary.org/obo/HP_0031176		
CL:0002092	biolink:Cell	bone marrow cell	A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.	FMA:83621|BTO:0004850	hp.json		http://purl.obolibrary.org/obo/CL_0002092		
HP:0006166	biolink:PhenotypicFeature	Tubular metacarpal bones		UMLS:C1859369	hp.json	Cylindrical shaped long bones of hand	http://purl.obolibrary.org/obo/HP_0006166		
HP:0006167	biolink:PhenotypicFeature	Prominent proximal interphalangeal joints		UMLS:C4025085	hp.json	Prominent innermost hinge joints	http://purl.obolibrary.org/obo/HP_0006167		
HP:0006169	biolink:PhenotypicFeature	Decreased mobility 3rd-5th fingers		UMLS:C1833882	hp.json	Decreased mobility 3rd-5th fingers	http://purl.obolibrary.org/obo/HP_0006169		
CHEBI:50860	biolink:ChemicalSubstance	organic molecular entity	Any molecular entity that contains carbon.		hp.json	organic compounds|organic entity|organic molecular entities	http://purl.obolibrary.org/obo/CHEBI_50860		3_STAR
HP:0006162	biolink:PhenotypicFeature	Soft tissue swelling of interphalangeal joints		UMLS:C1854913	hp.json	Soft tissue swelling of hinge joints	http://purl.obolibrary.org/obo/HP_0006162		
CL:0002095	biolink:Cell	hilus cell of ovary	A cell in the hilum of the ovary that produces androgens.	FMA:18710	hp.json	hilar cell of ovary	http://purl.obolibrary.org/obo/CL_0002095		
HP:0006163	biolink:PhenotypicFeature	Enlarged metacarpophalangeal joints		UMLS:C1859700	hp.json		http://purl.obolibrary.org/obo/HP_0006163		
CHEBI:35243	biolink:ChemicalSubstance	serine zwitterion	An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amnio group of serine.	Gmelin:2060272|Beilstein:3935647	hp.json	serine zwitterion|2-ammonio-3-hydroxypropanoate	http://purl.obolibrary.org/obo/CHEBI_35243		3_STAR
HP:0006165	biolink:PhenotypicFeature	Proportionate shortening of all digits		UMLS:C1862157	hp.json	Proportionate shortening of all digits	http://purl.obolibrary.org/obo/HP_0006165		
CHEBI:50857	biolink:ChemicalSubstance	anti-allergic agent	A drug used to treat allergic reactions.		hp.json	anti-allergic drug|anti-allergic drugs|anti-allergic agents	http://purl.obolibrary.org/obo/CHEBI_50857		3_STAR
UBERON:0002437	biolink:AnatomicalEntity	cerebral hemisphere white matter	White matter that is part of a cerebral hemisphere.	BTO:0000236|NCIT:C49347|UMLS:C1284115|UMLS:C0152295|EMAPA:35237|MA:0000945|UMLS:C0152295|FMA:61822|SCTID:361691006|FMA:256174|CALOHA:TS-2362|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=189|BIRNLEX:711|BAMS:cw|FMA:241998	hp.json	substantia medullaris cerebri|white matter structure of cerebral hemisphere|cerebral white matter|cerebral hemisphere white matter|region of cerebral white matter|hemisphere white matter	http://purl.obolibrary.org/obo/UBERON_0002437		pheno_slim
CHEBI:25899	biolink:ChemicalSubstance	pentitol	An alditol obtained by reduction of any pentose.		hp.json	pentitol|pentitols	http://purl.obolibrary.org/obo/CHEBI_25899		3_STAR
HP:0033763	biolink:PhenotypicFeature	Death in adulthood	Cessation of life at the age of 16 years or later.		hp.json		http://purl.obolibrary.org/obo/HP_0033763		
HP:0031100	biolink:PhenotypicFeature	Decreased inhibin B level	A reduced concentration of inhibin B in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031100		
HP:0033762	biolink:PhenotypicFeature	Middle cerebral artery stroke	Acute onset neurological deficits such as weakness, dizziness, numbness, issues with speech, or visual changes related to sudden impairment of blood flow to a part of the brain due to occlusion or rupture of the middle cerebral artery to the brain.		hp.json		http://purl.obolibrary.org/obo/HP_0033762		
CHEBI:35219	biolink:ChemicalSubstance	plant growth retardant			hp.json	plant growth inhibitors|plant growth inhibitor|plant growth retardants	http://purl.obolibrary.org/obo/CHEBI_35219		3_STAR
HP:0031101	biolink:PhenotypicFeature	Abnormal circulating antimullerian hormone concentration	Any deviation from the normal range of the antimullerian hormone, a peptide produced by the granulosa cells of follicles. Anti-Mullerian hormone (AMH), also known as Mullerian inhibiting substance, is produced by the granulosa cells of small antral follicles of the ovary. AMH has an inhibiting role in the ovary, contributing to follicular arrest. AMH levels in women are low until the age of 8, rise rapidly until puberty and decline steadily from the age of 25 until menopause, when AMH production ceases.		hp.json	Abnormal antimullerian hormone level	http://purl.obolibrary.org/obo/HP_0031101		
HP:0033765	biolink:PhenotypicFeature	Death in late adulthood	Death at an age of at least 60 years.		hp.json		http://purl.obolibrary.org/obo/HP_0033765		
PATO:0000688	biolink:NamedThing	asynchronous	A quality of a single process inhering in a bearer by virtue of the bearer's not occurring or existing at the same time or having the same period or phase.		hp.json		http://purl.obolibrary.org/obo/PATO_0000688		value_slim
HP:0031102	biolink:PhenotypicFeature	Increased antimullerian hormone level	An elevation above the normal range of the antimullerian hormone in the circulation.		hp.json	Increased plasma AMH	http://purl.obolibrary.org/obo/HP_0031102		
CHEBI:50858	biolink:ChemicalSubstance	corticosteroid	A natural or synthetic analogue of the hormones secreted by the adrenal gland.		hp.json	corticosteroides|corticoides|corticosteroids	http://purl.obolibrary.org/obo/CHEBI_50858		3_STAR
HP:0031103	biolink:PhenotypicFeature	Decreased antimullerian hormone level	A reduction below the normal range of the antimullerian hormone in the circulation.		hp.json	Decreased plasma AMH	http://purl.obolibrary.org/obo/HP_0031103		
HP:0033764	biolink:PhenotypicFeature	Death in middle age	Death between the age of 40 and 60 years.		hp.json		http://purl.obolibrary.org/obo/HP_0033764		
CHEBI:23230	biolink:ChemicalSubstance	chromanes			hp.json		http://purl.obolibrary.org/obo/CHEBI_23230		3_STAR
PATO:0000689	biolink:NamedThing	continuous	A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent.		hp.json	uninterrupted	http://purl.obolibrary.org/obo/PATO_0000689		value_slim
HP:0033761	biolink:PhenotypicFeature	Xanthogranulomatous pyelonephritis	Xanthogranulomatous pyelonephritis is a granulomatous inflammatory infiltrate composed of neutrophils, lymphocytes, plasma cells, xanthomatous histiocytes, and multinucleated giant cells.		hp.json		http://purl.obolibrary.org/obo/HP_0033761		
HP:0033760	biolink:PhenotypicFeature	Decreased maximal oxygen uptake	Maximum oxygen uptake (VO2max) is defined as the highest rate of oxygen uptake and utilization by the body during intense, maximal exercise, whereby further increases in work rate do not bring on additional rises in VO2 (i.e. plateau). VO2Max is typically measured with a treadmill anad ergometer and the participant exercises with increasing levels of intensity. VO2Max is the point at which oxygen uptake no longer increases despite an increase in workload.		hp.json		http://purl.obolibrary.org/obo/HP_0033760		
HP:0031108	biolink:PhenotypicFeature	Triceps weakness	A lack of strength in the triceps muscle, which normally is responsible for extending (straightening) the elbow and mediating certain shoulder movements.		hp.json		http://purl.obolibrary.org/obo/HP_0031108		
CL:0002067	biolink:Cell	type A enteroendocrine cell	An enteroendocrine cell that produces glucagon.	FMA:62939	hp.json		http://purl.obolibrary.org/obo/CL_0002067		
HP:0031109	biolink:PhenotypicFeature	Agalactia	Failure of secretion of milk following childbirth associated with an inability to breastfeed an infant.		hp.json	Lactation incapacity	http://purl.obolibrary.org/obo/HP_0031109		
CL:0002068	biolink:Cell	Purkinje myocyte	Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter.	BTO:0001032|FMA:14146	hp.json	Purkinje cell fiber|Purkinje muscle cell|myocytus conducens cardiacus	http://purl.obolibrary.org/obo/CL_0002068		
HP:0031104	biolink:PhenotypicFeature	Insulin receptor antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against the insulin receptor.		hp.json		http://purl.obolibrary.org/obo/HP_0031104		
HP:0033767	biolink:PhenotypicFeature	Abnormal single motor unit action potential	Abnormally high or low single motor unit action potential reading (-Pk Amps).		hp.json		http://purl.obolibrary.org/obo/HP_0033767		
HP:0031105	biolink:PhenotypicFeature	Abnormal uterus morphology	Any anomaly of the structure of the uterus		hp.json		http://purl.obolibrary.org/obo/HP_0031105		
HP:0033766	biolink:PhenotypicFeature	Polymelia	Polymelia is a congenital anomaly, which is defined as the presence of accessory limbs attached to various body regions and could be classified as cephalomelia (extra-limb attached to the head), notomelia (extra-limb attached to the back bone), thoracomelia (extra-limb attached to the thorax), and pyromelia (extra-limb attached to the pelvis).		hp.json		http://purl.obolibrary.org/obo/HP_0033766		
HP:0031106	biolink:PhenotypicFeature	T-shaped uterus	An abnormality of the uterus characterized by a normal uterine outline but with an abnormal T-shaped uterine cavity with narrowing cavity due to thickened lateral walls with a correlation 2/3 uterine corpus and 1/3 cervix. The abnormlaity is said to resemble the letter T in hysterosalpingographic imaging.		hp.json		http://purl.obolibrary.org/obo/HP_0031106		
HP:0033769	biolink:PhenotypicFeature	Fundic gland polyposis	Multiple polyps in the acid-secreting mucosa of the gastric body and fundus. Fundic gland polyps (FGP) are usually 1 to 5 mm in size, though larger polyps have been found. FGPs are typically sessile, shiny, translucent, pale to pinkish in color (resembling the surrounding mucosa), and often exhibit tiny surface blood vessels. These polyps have characteristically been observed to chunk off or detach entirely at the base when removed with cold forceps, in contrast to other types of gastric polyps.		hp.json	Gastric polyposis|Proximal polyposis of the stomach|Fundic gland polyps	http://purl.obolibrary.org/obo/HP_0033769		
HP:0031107	biolink:PhenotypicFeature	Decreased fibular diameter	Reduced width of the cross sectional diameter of the fibula.		hp.json	Thin fibula	http://purl.obolibrary.org/obo/HP_0031107		
HP:0033768	biolink:PhenotypicFeature	Penile thrush	Overgrowth of candida albicans in the penis.		hp.json	Penile candidiasis	http://purl.obolibrary.org/obo/HP_0033768		
UBERON:0002445	biolink:AnatomicalEntity	ulnare	The postaxial bone of the proximal carpal region. Found in close approximation to the ulna, often in articulation[PHENOSCAPE:ad].	NCIT:C12858|MA:0001347|EMAPA:36167|AAO:0000845|galen:Triquetral|FMA:23715|UMLS:C0223739	hp.json	os triquetrum|triquetral bone|triangular|ulnar carpal bone|os ulnare|cuneiform bone of manus|triangular bone|triquetrum|cuneiform of hand|triquetral|cuneiform bone of hand	http://purl.obolibrary.org/obo/UBERON_0002445		uberon_slim
UBERON:0002446	biolink:AnatomicalEntity	patella	A large sesamoid bone found in the distal femur/proximal tibial region of the hindlimb of tetrapods. The patella is the attachment site for proximal hindlimb tendons.[PHENOSCAPE:ad].	EMAPA:35668|NCIT:C33282|MESH:D010329|GAID:203|galen:Patella|FMA:24485|UMLS:C0030647|MA:0001374	hp.json	patella|knee bone|knee cap	http://purl.obolibrary.org/obo/UBERON_0002446		human_reference_atlas|uberon_slim|pheno_slim
CL:0002062	biolink:Cell	type I pneumocyte	A type I pneumocyte is a flattened, branched pneumocyte that covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange.	BTO:0000780|FMA:62500	hp.json	type I alveolar epithelial cells|membranous pneumocytes|ATI|type I alveolar cells|squamous alveolar cell|pulmonary alveolar type I cell|small alveolar cells|squamous alveolar lining cell|type 1 alveolar epithelial cells|AT1|type 1 pneumocyte|lung type 1 cells	http://purl.obolibrary.org/obo/CL_0002062		
UBERON:0002443	biolink:AnatomicalEntity	choroidal blood vessel	A blood vessel that is part of a choroid [Automatically generated definition].	FMA:76550|MA:0001237|EMAPA:17828	hp.json	vasa sanguinea choroideae|blood vessel of posterior uvea|blood vessel of choroid coat|choroid coat blood vessel|posterior uvea blood vessel|choroidea blood vessel|blood vessel of choroid|choroid blood vessels set|choroid blood vessel|blood vessel of choroidea|set of choroid blood vessels|choroid blood vessels	http://purl.obolibrary.org/obo/UBERON_0002443		pheno_slim
UBERON:0002442	biolink:AnatomicalEntity	axillary nerve trunk		FMA:65265|EMAPA:37719|MA:0001175	hp.json	trunk of right axillary nerve|circumflex nerve trunk|right axillary neural trunk	http://purl.obolibrary.org/obo/UBERON_0002442		
CL:0002064	biolink:Cell	pancreatic acinar cell	A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.	FMA:63032|CALOHA:TS-0737|BTO:0000028	hp.json	acinar cell of pancreas	http://purl.obolibrary.org/obo/CL_0002064		
CHEBI:50846	biolink:ChemicalSubstance	immunomodulator	Biologically active substance whose activity affects or plays a role in the functioning of the immune system.	Wikipedia:Immunotherapy	hp.json	Biomodulator|Immunological factor|immunomodulators|Immunologic factor|Immune factor	http://purl.obolibrary.org/obo/CHEBI_50846		3_STAR
UBERON:0002427	biolink:AnatomicalEntity	arm skin	A zone of skin that is part of an arm [Automatically generated definition].	UMLS:C0222204|EMAPA:37350|NCIT:C52754|MA:0000596	hp.json	skin of arm|brachial region skin	http://purl.obolibrary.org/obo/UBERON_0002427		
UBERON:0002426	biolink:AnatomicalEntity	chest muscle	Any muscle organ that is part of a chest [Automatically generated definition].	EMAPA:17748|FMA:9619|EMAPA:17747|MA:0000548|CALOHA:TS-1037|BTO:0000508	hp.json	anterior thoracic region muscle organ|muscle organ of anterolateral part of thorax|muscle organ of chest|muscle organ of front of thorax|muscle of thorax|muscle organ of anterior thoracic region|anterolateral part of thorax muscle organ|musculus thoracicus|front of thorax muscle organ|chest muscle organ|thoracic muscle	http://purl.obolibrary.org/obo/UBERON_0002426		
UBERON:0002429	biolink:AnatomicalEntity	cervical lymph node	Cervical lymph nodes are lymph nodes found in the neck. [WP,unvetted].	UMLS:C0588054|NCIT:C32298|FMA:61213|MA:0000736	hp.json	lymph node of neck	http://purl.obolibrary.org/obo/UBERON_0002429		pheno_slim|uberon_slim
UBERON:0002428	biolink:AnatomicalEntity	limb bone	A bone that is part of a limb [Automatically generated definition].	NCIT:C32223|MAT:0000151|UMLS:C0582791|MIAA:0000151|EFO:0000945	hp.json	bone of extremity|free limb bone|bone of limb	http://purl.obolibrary.org/obo/UBERON_0002428		pheno_slim|efo_slim
HP:0031111	biolink:PhenotypicFeature	Cutaneous hamartoma	A hamartoma (tissue malformation consisting of an abnormal mixture of constitutive components) originating in the skin.		hp.json	Skin hamartoma	http://purl.obolibrary.org/obo/HP_0031111		
HP:0033774	biolink:PhenotypicFeature	Impaired renal tubular reabsorption of uric acid	Decreased renal tubular reabsorption of uric acid.		hp.json		http://purl.obolibrary.org/obo/HP_0033774		
PATO:0010001	biolink:NamedThing	disconnected			hp.json		http://purl.obolibrary.org/obo/PATO_0010001		
HP:0033773	biolink:PhenotypicFeature	Decreased RV/TLC ratio	An abnormally low ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining after maximal expiration and TLC is the total amount of air in the lungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and body plethysmography.		hp.json		http://purl.obolibrary.org/obo/HP_0033773		
HP:0033776	biolink:PhenotypicFeature	Enamel pearls	Small nodules of enamel on the root of a tooth.		hp.json		http://purl.obolibrary.org/obo/HP_0033776		
HP:0033775	biolink:PhenotypicFeature	Pulmonary imaging sign	An abnormal pulmonary imaging finding defined by eponym or reference to signs, symbols, or naturalistic images.		hp.json		http://purl.obolibrary.org/obo/HP_0033775		
HP:0033770	biolink:PhenotypicFeature	Gastric adenocarcinoma	An adenocarcinoma arising from the stomach glandular epithelium. Gastric carcinoma often produces no specific symptoms when it is superficial and potentially surgically curable, although up to 50% of patients may have nonspecific gastrointestinal complaints such as dyspepsia.		hp.json		http://purl.obolibrary.org/obo/HP_0033770		
HP:0033772	biolink:PhenotypicFeature	Abnormal RV/TLC ratio	Any deviation from the normal ratio of residual volume (RV) to total lung capacity (TLC) on pulmonary function testing. RV is the amount of air remaining aftermaximal expiration and TLC is the total amount of air in theungs at full inspiration. These volumes cannot be determined by spirometry, but can be measured by inert gas dilution, nitrogen washout, and body plethysmography.		hp.json		http://purl.obolibrary.org/obo/HP_0033772		
HP:0031110	biolink:PhenotypicFeature	Twin-to-twin transfusion	As a result of sharing a single placenta, the blood supplies of monochorionic twin fetuses can become connected, so that they share blood circulation: although each fetus uses its own portion of the placenta, the connecting blood vessels within the placenta allow blood to pass from one twin to the other.Depending on the number, type and direction of the interconnecting blood vessels (anastomoses), blood can be transferred disproportionately from one twin (the donor) to the other (the recipient). This state of transfusion causes the donor twin to have decreased blood volume, retarding the donor's development and growth. The blood volume of the recipient twin is increased, which can strain the fetus's heart and eventually lead to heart failure.		hp.json	Twin to twin transfusion syndrome	http://purl.obolibrary.org/obo/HP_0031110		
UBERON:0014411	biolink:AnatomicalEntity	greater sciatic notch	On the dorsal border of the wing of the ilium , at it's junction with the shaft is a cut away. This forms the Greater sciatic notch. The sciatic nerve runs over the notch in passage to the hindlimb.	FMA:16902	hp.json	greater sacrosciatic notch|incisura ischiadica major	http://purl.obolibrary.org/obo/UBERON_0014411		pheno_slim
CHEBI:23240	biolink:ChemicalSubstance	chromophore	The part (atom or group of atoms) of a molecular entity in which the electronic transition responsible for a given spectral band is approximately localized.	Wikipedia:Chromophore	hp.json	chromophore|chromophores	http://purl.obolibrary.org/obo/CHEBI_23240		3_STAR
HP:0033771	biolink:PhenotypicFeature	Pleuritic chest pain	Pleuritic chest pain is characterized by sudden and intense sharp, stabbing, or burning pain in the chest when inhaling and exhaling.		hp.json		http://purl.obolibrary.org/obo/HP_0033771		
CHEBI:37886	biolink:ChemicalSubstance	adrenergic agonist	An agent that selectively binds to and activates adrenergic receptors.		hp.json	adrenergic receptor agonist|adrenomimetic|adrenergic agonists|adrenomimetics|adrenoceptor agonists	http://purl.obolibrary.org/obo/CHEBI_37886		3_STAR
CHEBI:35223	biolink:ChemicalSubstance	catalyst	A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction.		hp.json	catalyst|Katalysator|catalizador|catalyseur	http://purl.obolibrary.org/obo/CHEBI_35223		3_STAR
CL:0002078	biolink:Cell	meso-epithelial cell	Epithelial cell derived from mesoderm or mesenchyme.	FMA:69076	hp.json	epithelial mesenchymal cell	http://purl.obolibrary.org/obo/CL_0002078		
HP:0031119	biolink:PhenotypicFeature	Bicuspid aortic valve with right-left cusp fusion	A type of bicuspid aortic valve (BAV) characterized by a single raphe between the right and left cusps (RL fusion pattern). This results in two leaflefts with an anterior-posterior leaflet orientation (also called the typical pattern). There is thus one completely developed noncoronary cusp, two completely developed commissures, and one raphe between the underdeveloped left and right coronary cusps extending to the corresponding malformed commissure.		hp.json		http://purl.obolibrary.org/obo/HP_0031119		
CHEBI:35222	biolink:ChemicalSubstance	inhibitor	A substance that diminishes the rate of a chemical reaction.		hp.json	inhibitor|inhibiteur|inhibidor|inhibitors	http://purl.obolibrary.org/obo/CHEBI_35222		3_STAR
CL:0002077	biolink:Cell	ecto-epithelial cell	An epithelial cell derived from ectoderm.	FMA:69074	hp.json		http://purl.obolibrary.org/obo/CL_0002077		
HP:0033778	biolink:PhenotypicFeature	Leung cusp	An additional cusp located in the middle of the occlusal surface.		hp.json		http://purl.obolibrary.org/obo/HP_0033778		
HP:0033777	biolink:PhenotypicFeature	Supernumerary cusp	Additional cusps of a dental crown.		hp.json	Additional cusp|Extra cusp	http://purl.obolibrary.org/obo/HP_0033777		
PATO:0000692	biolink:NamedThing	heterochronic	A quality of a single process inhering in a bearer by virtue of the bearer's origin or development at an unusual time or out of the regular sequence.		hp.json		http://purl.obolibrary.org/obo/PATO_0000692		value_slim
HP:0031117	biolink:PhenotypicFeature	Purely bicuspid aortic valve	A type of bicuspid aortic valve (BAV) characterized by two equal-sized cusps, with no raphe and only two commissures. There is a lateral arrangement of the free edge of the cusps. Note that this differs from some other forms of BAV in which there are three commissures and two of the three cusps are joined by a raphe forming two functional leaflets. This type of BAV often is associated with aortic stenosis.		hp.json		http://purl.obolibrary.org/obo/HP_0031117		
HP:0031118	biolink:PhenotypicFeature	Single raphe bicuspid aortic valve	A type of bicuspid aortic valvue (BAV) characterized by the presence of a single raphe that extends from the commissure to the free edge of the two underdeveloped, conjoint cusps, resulting in two leaflets of unequal size.		hp.json		http://purl.obolibrary.org/obo/HP_0031118		
PATO:0000694	biolink:NamedThing	premature	A quality of a process which starts earlier than the natural start time or the reference process.		hp.json	precocious|advanced|early	http://purl.obolibrary.org/obo/PATO_0000694		value_slim
HP:0033779	biolink:PhenotypicFeature	Barrel-shaped tooth	A tooth crown with convex mesial and distal surfaces.		hp.json		http://purl.obolibrary.org/obo/HP_0033779		
CL:0002072	biolink:Cell	nodal myocyte	A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.	FMA:67101|BTO:0004190	hp.json	P cell|myocytus nodalis|cardiac pacemaker cell|pacemaker cell	http://purl.obolibrary.org/obo/CL_0002072		
UBERON:0002435	biolink:AnatomicalEntity	striatum	A region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.[GO].	ncithesaurus:Striatum|MBA:477|FMA:83683|EMAPA:17549|UMLS:C0162512|HBA:4277|BM:N|DMBA:15851|BTO:0000418|PBA:10080|EFO:0000109|BIRNLEX:1672|DHBA:10333|FMA:77618|BAMS:STR|BAMS:Str|MESH:D017072|MA:0000891|NCIT:C111122|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=225|BAMS:Striatum	hp.json	caudate putamen|striatum|striate nucleus|neostriatum|neostriatum|corpus striatum|striatum of neuraxis|striated nucleus|dorsal striatum|corpus striatum (Zilles)|neuraxis striatum	http://purl.obolibrary.org/obo/UBERON_0002435		pheno_slim|uberon_slim
CL:0002074	biolink:Cell	myocardial endocrine cell	The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides).	FMA:67111	hp.json		http://purl.obolibrary.org/obo/CL_0002074		
CL:0002073	biolink:Cell	transitional myocyte	Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes.	FMA:67142	hp.json		http://purl.obolibrary.org/obo/CL_0002073		
CHEBI:35221	biolink:ChemicalSubstance	antimetabolite	A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.	Wikipedia:Antimetabolite	hp.json	antimetabolite|antimetabolites	http://purl.obolibrary.org/obo/CHEBI_35221		3_STAR
CL:0002076	biolink:Cell	endo-epithelial cell	An epithelial cell derived from endoderm.	FMA:69075	hp.json		http://purl.obolibrary.org/obo/CL_0002076		
UBERON:0002419	biolink:AnatomicalEntity	skin gland	A gland that is part of a skin of body [Automatically generated definition].	MA:0000146|SCTID:110485007|EMAPA:35774|FMA:71878	hp.json	skin glands set|set of skin glands|skin glands|glandulae cutis	http://purl.obolibrary.org/obo/UBERON_0002419		organ_slim
CHEBI:23213	biolink:ChemicalSubstance	choline ester			hp.json		http://purl.obolibrary.org/obo/CHEBI_23213		
UBERON:0002416	biolink:AnatomicalEntity	integumental system	Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle.	UMLS:C0037267|XAO:0000176|Wikipedia:Integumentary_system|TADS:0000108|BILA:0000118|SCTID:361692004|VHOG:0000403|EHDAA:6520|NCIT:C12907|MAT:0000033|MESH:D034582|FBbt:00004969|EV:0100151|EFO:0000807|EHDAA2:0000836|MIAA:0000033|AEO:0000154|EMAPA:17524|FMA:72979|CARO:0002001|HAO:0000421|CALOHA:TS-1299|EHDAA2_RETIRED:0003154|galen:Surface|MA:0000014	hp.json	integumentum commune|integumentary system|body surface|organism surface|external covering of organism|dermal system|integumentum commune|surface	http://purl.obolibrary.org/obo/UBERON_0002416		grouping_class|pheno_slim|efo_slim
UBERON:0002415	biolink:AnatomicalEntity	tail	An external caudal extension of the body. In chordates, the tail is post-anal, in other animals the anus ends in the tail.	AEO:0000109|EFO:0000963|BILA:0000117|BTO:0001348|GAID:1245|OpenCyc:Mx4rvVjiC5wpEbGdrcN5Y29ycA|WBbt:0005741|MAT:0000094|EHDAA:9198|MIAA:0000094|MESH:D013623	hp.json	caudal subdivision	http://purl.obolibrary.org/obo/UBERON_0002415		grouping_class|pheno_slim|efo_slim|uberon_slim
CHEBI:23217	biolink:ChemicalSubstance	cholines			hp.json		http://purl.obolibrary.org/obo/CHEBI_23217		
UBERON:0002418	biolink:AnatomicalEntity	cartilage tissue	Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts.	TAO:0001501|VSAO:0000040|galen:Cartilage|NCIT:C32268|ZFA:0005622|BTO:0000206|MESH:D002356|Wikipedia:Cartilage|MAT:0000189|OpenCyc:Mx4rvVjeOZwpEbGdrcN5Y29ycA|VHOG:0001207|XAO:0000170|GAID:99|EMAPA:32730|NCIT:C12373|MIAA:0000189|EV:0100141|EHDAA2:0003087|EFO:0000949|SCTID:309312004|AEO:0000087|MA:0000104|FMA:37377|AAO:0000060|UMLS:C0007301	hp.json	chondrogenic tissue|cartilage tissue|cartilages|cartilage|portion of cartilage tissue|cartilaginous tissue	http://purl.obolibrary.org/obo/UBERON_0002418		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0002417	biolink:AnatomicalEntity	abdominal segment of trunk	The abdominal segment of the torso.	FMA:259211|MA:0000021|SCTID:362875007|EMAPA:35104|Wikipedia:Lumbar	hp.json	lumbar region|lower trunk|lower body|lumbar region|abdomen/pelvis/perineum	http://purl.obolibrary.org/obo/UBERON_0002417		
UBERON:0014401	biolink:AnatomicalEntity	renal venous blood vessel	Any member of the network of tubes that return blood from the renal tissues to the systemic circulation.	MA:0002591|EMAPA:31450	hp.json	kidney venous system|kidney venous blood vessel|venous blood vessel of kidney	http://purl.obolibrary.org/obo/UBERON_0014401		pheno_slim
HP:0031122	biolink:PhenotypicFeature	Two-raphe bicuspid aortic valve	A type of bicuspid aortic valvue (BAV) characterized by the presence of two raphes that each extend from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV has developmental anlagen of three cusps, commissures, and sinuses, but two commissures are more or less malformed and obliterated, giving rise to a raphe, a fibrous ridge, which extends from the commissure to the free edge of the two underdeveloped, conjoint cusps. This type of BAV is typically associated with a high degree of aortic stenosis.		hp.json		http://purl.obolibrary.org/obo/HP_0031122		
HP:0033785	biolink:PhenotypicFeature	Enamel agenesis	Complete or almost complete absence of enamel.		hp.json		http://purl.obolibrary.org/obo/HP_0033785		
UBERON:0014402	biolink:AnatomicalEntity	sex-specific anatomical structure	A part of the body present only in a specific gender.	WBbt:0005752|AEO:0000174	hp.json	gender-specific anatomical structure|sex-specific|gender-specific	http://purl.obolibrary.org/obo/UBERON_0014402		
HP:0033784	biolink:PhenotypicFeature	Dentin dysplasia	This is a bundled term as dentin dysplasia is composed of short roots with pointed ends and taurodontism and intrapulpal calcifications.		hp.json		http://purl.obolibrary.org/obo/HP_0033784		
HP:0031123	biolink:PhenotypicFeature	Recurrent gastroenteritis	Increased susceptibility to gastroenteritis, an infectious inflammationof the stomach and small intestines manifested by signs and symptoms such as diarheas and abdominal pain, as manifested by recurrent episodes of gastroenteritis.		hp.json		http://purl.obolibrary.org/obo/HP_0031123		
HP:0033787	biolink:PhenotypicFeature	Cementum hypoplasia	The decrease or absence of cementum. The cementum anchors the periodontal ligament attachment fiber between the tooth root and the alveolar bone. Its absence leads to early loss of teeth.		hp.json	Cementum aplasia	http://purl.obolibrary.org/obo/HP_0033787		
HP:0031124	biolink:PhenotypicFeature	Decreased platelet thromboxane A2 receptor	Decreased cell membrane concentration of thromboxane A2 receptor that is stimulated by thromboxane A2 (TBXA2).		hp.json		http://purl.obolibrary.org/obo/HP_0031124		
HP:0031125	biolink:PhenotypicFeature	Decreased platelet alpha-2A-adrenergic receptor	Decreased cell membrane concentration of alpha-2A adrenergic receptor that is stimulated by epinephrine.		hp.json		http://purl.obolibrary.org/obo/HP_0031125		
HP:0033786	biolink:PhenotypicFeature	Hypomature enamel	Enamel with a white or brown discoloration without hypoplasia.		hp.json	Enamel opacity	http://purl.obolibrary.org/obo/HP_0033786		
UBERON:0014404	biolink:AnatomicalEntity	female anatomical structure	A part of the body present only in females.	AEO:0000176	hp.json		http://purl.obolibrary.org/obo/UBERON_0014404		
HP:0033781	biolink:PhenotypicFeature	Tapered tooth	A tooth with a crown that narrows from proximal toward the incisal edge. Tapering of teeth typically involves incisors.		hp.json		http://purl.obolibrary.org/obo/HP_0033781		
HP:0033780	biolink:PhenotypicFeature	Bulbous tooth	A tooth crown with a marked cervical area constriction.		hp.json		http://purl.obolibrary.org/obo/HP_0033780		
HP:0033783	biolink:PhenotypicFeature	Molar incisor malformation	Molar incisor malfomation (MIM) is composed of normal crown with marked cervical constriction, thin, narrow short roots which is a combination of signs that occurs in deciduous and permanent molars.		hp.json		http://purl.obolibrary.org/obo/HP_0033783		
HP:0031120	biolink:PhenotypicFeature	Bicuspid aortic valve with right-noncoronary cusp fusion	A type of bicuspid aortic valve (BAV) characterized by a single raphe between the right and noncoronary cusps (RN fusion pattern). This results in two leaflets with right-left leaflet orientation (also called the atypical pattern). There is thus one completely developed left cusp, two completely developed commissures, and one raphe between the underdeveloped right and noncoronary coronary cusps extending to the corresponding malformed commissure.		hp.json		http://purl.obolibrary.org/obo/HP_0031120		
UBERON:0014400	biolink:AnatomicalEntity	hepatic sinusoidal space	A sinusoidal space that is part of a hepatic sinusoid.	FMA:262090	hp.json	lumen of hepatic sinusoid	http://purl.obolibrary.org/obo/UBERON_0014400		
HP:0033782	biolink:PhenotypicFeature	Semilunar tooth	An incisor with a half-moon shape incisal edge.		hp.json	Crescent-shape tooth|Tooth, semilunar|Hutchinson incisor|Semicircular tooth	http://purl.obolibrary.org/obo/HP_0033782		
HP:0031121	biolink:PhenotypicFeature	Bicuspid aortic valve with left-noncoronary cusp fusion	A type of bicuspid aortic valve (BAV) characterized by a single raphe between the left and noncoronary cusps (LN fusion pattern). There is thus one completely developed right cusp, two completely developed commissures, and one raphe between the underdeveloped left and noncoronary coronary cusps extending to the corresponding malformed commissure.		hp.json		http://purl.obolibrary.org/obo/HP_0031121		
HP:0031126	biolink:PhenotypicFeature	Impaired clot retraction	Platelets contain contractile proteins (actin and myosin) that induce clot retraction. As the platelets contract, they pull on the surrounding fibrin strands, squeezing serum form the mass, compacting the clot and drawing the ruptured edges of the blood vessel more closely together. Clot retraction is directly proportional to the platelet count and inversely proportional to the fibrinogen concentration.		hp.json		http://purl.obolibrary.org/obo/HP_0031126		
HP:0033789	biolink:PhenotypicFeature	Triggered by cheese ingestion	Applies to a sign or symptom that is provoked or brought about by eating cheese.		hp.json		http://purl.obolibrary.org/obo/HP_0033789		
HP:0033788	biolink:PhenotypicFeature	Cementum overgrowth	Excess of cementum on the tooth root surface.		hp.json	Cementation hyperplasia|Cementum hypertrophy|Cementum overdeveloped|Drumstick-shaped root|Hypercementosis	http://purl.obolibrary.org/obo/HP_0033788		
HP:0031127	biolink:PhenotypicFeature	Impaired convulxin-induced platelet aggregation	Abnormal response to convulxin as manifested by reduced or lacking aggregation of platelets upon addition of convulxin.		hp.json		http://purl.obolibrary.org/obo/HP_0031127		
HP:0031128	biolink:PhenotypicFeature	Impaired collagen-related peptide-induced platelet aggregation	Abnormal response to collagen-related peptide (CRP) as manifested by reduced or lacking aggregation of platelets upon addition of CRP.		hp.json		http://purl.obolibrary.org/obo/HP_0031128		
HP:0031129	biolink:PhenotypicFeature	Impaired phorbol myristate acetate-induced platelet aggregation	Abnormal response to phorbol myristate acetate (PMA) as manifested by reduced or lacking aggregation of platelets upon addition of PMA.		hp.json		http://purl.obolibrary.org/obo/HP_0031129		
UBERON:0002423	biolink:AnatomicalEntity	hepatobiliary system	The part of the digestive system that contains the liver and the biliary system.	MAT:0000024|CALOHA:TS-1308|AAO:0011056|EV:0100088|MIAA:0000024|UMLS:C1711359|NCIT:C43612|EMAPA:16840|MA:0000324|EHDAA2:0000998|ZFA:0000036|VHOG:0000294|EFO:0000800|XAO:0000132|TAO:0000036|EHDAA:2189	hp.json	hepaticobiliary system|liver/biliary system|liver and biliary system	http://purl.obolibrary.org/obo/UBERON_0002423		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0002422	biolink:AnatomicalEntity	fourth ventricle	Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures.	EV:0100310|BTO:0003426|MA:0000196|TAO:0000110|EHDAA2:0000100|BAMS:4V|VHOG:0000006|FMA:78469|DHBA:12805|NCIT:C12828|AAO:0011043|MBA:145|BAMS:V4|DHBA:10669|DMBA:126651782|MESH:D020546|BIRNLEX:1256|CALOHA:TS-2015|GAID:610|OpenCyc:Mx4rv-7Q6pwpEbGdrcN5Y29ycA|HBA:9421|BM:Pons-4V|EHDAA:896|ZFA:0000110|EMAPA:16917|XAO:0003099|UMLS:C0149556	hp.json	rhombencephalic vesicle|ventriculus quartus|IVth ventricle|ventricle of rhombencephalon|ventricle IV|hindbrain ventricle|fourth ventricle proper|rhombencephalic ventricle|4th ventricle|ventricle of hindbrain	http://purl.obolibrary.org/obo/UBERON_0002422		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0002425	biolink:AnatomicalEntity	visceral serous pericardium	Visceral serous membrane which is continuous with the parietal serous pericardium and is attached to the myocardium[FMA].	EMAPA:19032|FMA:84882|Wikipedia:Visceral_pericardium|EMAPA:16589|SCTID:243955001|MA:0000484|VHOG:0000538	hp.json	visceral pericardium|visceral layer of serous pericardium|epicardium|visceral lamina of serous pericardium|pericardium visceral mesothelium|serous visceral pericardium|lamina visceralis pericardii serosi|lamina visceralis pericardii serosi	http://purl.obolibrary.org/obo/UBERON_0002425		pheno_slim|uberon_slim
UBERON:0002424	biolink:AnatomicalEntity	oral epithelium	An epithelium that is part of the mouth and lines the oral cavity, typically stratified squamous, and may be para-, ortho- or non- keratinized. Primary barrier between oral environment and deeper tissues.	EMAPA:16839|CALOHA:TS-0715|UMLS:C1709332|ZFA:0000816|EHDAA:2187|BTO:0001775|TAO:0000816|NCIT:C49595|EMAPA:26942|VHOG:0000187|FMA:265152|MA:0000344|XAO:0003201|EHDAA2:0001325|AAO:0010357	hp.json	epithelium of oral mucosa|epithelium of mucosa of mouth	http://purl.obolibrary.org/obo/UBERON_0002424		vertebrate_core
UBERON:0002421	biolink:AnatomicalEntity	hippocampal formation	Hippocampus (proper) plus dentate gyrus and subiculum[definition derived from NIF comments and ontology alignment].	DHBA:10294|EMAPA:35405|HBA:4249|BAMS:Hi|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=177|UMLS:C0175202|BAMS:HiF|BM:Tel-HF|MBA:1089|BIRNLEX:715|MA:0000189|BTO:0000601|PBA:4003|BAMS:HPF|FMA:74038	hp.json	major hippocampus|formatio hippocampi|seahorse|primal cortex|hippocampus|archipallium|hippocampus (Crosby)	http://purl.obolibrary.org/obo/UBERON_0002421		pheno_slim|uberon_slim
CL:0002043	biolink:Cell	CD34-positive, CD38-negative multipotent progenitor cell	A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative.		hp.json		http://purl.obolibrary.org/obo/CL_0002043		
UBERON:0002420	biolink:AnatomicalEntity	basal ganglion	An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified].	BTO:0000235|CALOHA:TS-1149|EFO:0000904|FMA:62514|DHBA:10332	hp.json	basal nucleus|basal ganglia|nuclei basales|basal ganglion of telencephalon	http://purl.obolibrary.org/obo/UBERON_0002420		efo_slim|uberon_slim|pheno_slim
UBERON:0002409	biolink:AnatomicalEntity	pericardial fluid	Transudate contained in the pericardial cavity.[FMA].	FMA:9887|MESH:D000069236|MA:0002530|BTO:0001016|Wikipedia:Pericardial_fluid	hp.json		http://purl.obolibrary.org/obo/UBERON_0002409		uberon_slim
UBERON:0002408	biolink:AnatomicalEntity	parietal serous pericardium	Parietal serous membrane which is part of the pericardium and forms the outer layer of the pericardial sac.	SCTID:243956000|Wikipedia:Parietal_pericardium|EHDAA:3422|VHOG:0000537|MA:0000483|FMA:9870|EHDAA:5378|EMAPA:19031|UMLS:C0225969|NCIT:C94500	hp.json	parietal pericardium|parietal layer of serous pericardium|pericardial sac|pericardial sac|lamina parietalis pericardii|lamina parietalis (pericardii serosum)	http://purl.obolibrary.org/obo/UBERON_0002408		pheno_slim|uberon_slim
HP:0033790	biolink:PhenotypicFeature	Thistle tube shaped pulp	A thistle tube shape of the pulp chamber, meaning an enlarged coronal pulp chamber with narrow pulp canals giving a radiographic appearance of the shape of a thistle tube or a flame. It may occur isolated or associated with other dental anomalies and rare diseases such as dentinogenesis imperfecta, which should be assessed and coded separately. The diagnosis thistle tube shape pulp requires clinical and radiographic examinations.		hp.json	Flame-shaped pulp	http://purl.obolibrary.org/obo/HP_0033790		
UBERON:0002405	biolink:AnatomicalEntity	immune system	Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies.	TAO:0001159|SCTID:362590003|Wikipedia:Immune_system|MESH:D007107|UMLS:C0020962|AAO:0011003|OpenCyc:Mx4rvWNkm5wpEbGdrcN5Y29ycA|XAO:0003152|BILA:0000104|BTO:0005810|VHOG:0001247|GAID:328|FMA:9825|NCIT:C12735|ZFA:0001159|MA:0002711	hp.json		http://purl.obolibrary.org/obo/UBERON_0002405		pheno_slim|uberon_slim|vertebrate_core
UBERON:0002407	biolink:AnatomicalEntity	pericardium	The combination of pericardial sac (a double-walled sac containing the heart and the roots of the great vessels) plus fibrous pericardium.	BSA:0000090|EMAPA:16133|NCIT:C13005|EFO:0000820|MA:0000099|ZFA:0000054|MAT:0000454|VHOG:0001280|MESH:D010496|OpenCyc:Mx4rvoCLgJwpEbGdrcN5Y29ycA|EV:0100023|TAO:0000054|galen:Pericardium|EHDAA:5376|UMLS:C0031050|SCTID:181295003|AAO:0010817|XAO:0004182|GAID:569|FMA:9869|Wikipedia:Pericardium|CALOHA:TS-0761|BTO:0000717|RETIRED_EHDAA2:0001443	hp.json		http://purl.obolibrary.org/obo/UBERON_0002407		vertebrate_core|pheno_slim|efo_slim|uberon_slim
UBERON:0002406	biolink:AnatomicalEntity	pericardial sac	A double-walled sac containing the heart and the roots of the great vessels.	SCTID:361326002|TAO:0000054|FMA:9868|RETIRED_EHDAA2:0001443	hp.json	pericardium	http://purl.obolibrary.org/obo/UBERON_0002406		vertebrate_core|uberon_slim
HP:0031133	biolink:PhenotypicFeature	Increased annexin V binding to platelet phosphatidylserine	Elevated binding of annexin V to platelet membrane, which is mediated by exposed phosphatidylserine. This can be measured by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031133		
HP:0033796	biolink:PhenotypicFeature	Abnormal leukocyte physiology	A functional abnormality of a white blood cell.		hp.json		http://purl.obolibrary.org/obo/HP_0033796		
HP:0033795	biolink:PhenotypicFeature	Growth without growth hormone			hp.json		http://purl.obolibrary.org/obo/HP_0033795		
HP:0031134	biolink:PhenotypicFeature	Cor triatrium sinister	A developmental anomaly of the heart characterized by the presence of three atria because the left atrium is divided by an abnormal septum.		hp.json		http://purl.obolibrary.org/obo/HP_0031134		
HP:0031135	biolink:PhenotypicFeature	Triggered by physical trauma	Applies to a sign or symptom that is provoked or brought about by exposure to a trauma (injury to tissue).		hp.json	Physical trauma triggered symptoms	http://purl.obolibrary.org/obo/HP_0031135		
HP:0033798	biolink:PhenotypicFeature	Impaired leukocyte adhesion	During states of inflammation, white blood cells (leukocytes) play a key role in maintaining tissue homeostasis through elimination of pathogens and removal of damaged tissue. Leukocytes migrate to the site of inflammation by crawling over and through the blood vessel wall, into the tissue. This term refers to a defect in the attachment of leukocytes to the blood vessel wall, which is a key step required before they can pass through gaps of the endothelial cells of the blood vessel wall to migrate to the site of inflammation.		hp.json		http://purl.obolibrary.org/obo/HP_0033798		
HP:0031136	biolink:PhenotypicFeature	Decreased acrosin in sperm head	A reduced amount of the enzyme acrosin in the sperm head acrosome. The acrosome is an organelle in the anterior half of the head of spermatozoa, and acrosin is a protease that contributes to the digestation of the zona pellucida in the fertilization process.		hp.json		http://purl.obolibrary.org/obo/HP_0031136		
HP:0033797	biolink:PhenotypicFeature	Leukocyte migration defect	Any abnormality of leukocyte motility in response to chemokines, which is required for the inflammatory response to infections, and for organ development, tissues homeostasis, and vascularization.		hp.json	Abnormal leukocyte migration|Defects of leukocyte migration	http://purl.obolibrary.org/obo/HP_0033797		
HP:0033792	biolink:PhenotypicFeature	Cross bite	Lingual occlusion of buccal cusps and/or incisal edge of maxillary teeth to the buccal cusps and/or incisal edge of mandibular teeth.		hp.json		http://purl.obolibrary.org/obo/HP_0033792		
HP:0033791	biolink:PhenotypicFeature	Tooth ankylosis	Fusion of a tooth with alveolar bone.		hp.json		http://purl.obolibrary.org/obo/HP_0033791		
HP:0031130	biolink:PhenotypicFeature	Impaired calcium ionophore-induced platelet aggregation	Abnormal response to calcium Ionophore (such as A23187) as manifested by reduced or lacking aggregation of platelets upon addition of the ionophore.		hp.json	Impaired Ca ionophore-induced platelet aggregation|Impaired Ca2+ ionophore-induced platelet aggregation	http://purl.obolibrary.org/obo/HP_0031130		
HP:0033794	biolink:PhenotypicFeature	Acral overgrowth	Excessive growth of hands and feet (predominantly due to soft tissue swelling). Typical manifestations include shoe size increase, foot enlargment, glove tightness, and hand enlargement.		hp.json	Acromegalic growth|Acral enlargement|Acromegaly|Acral hypertrophy	http://purl.obolibrary.org/obo/HP_0033794		
HP:0031131	biolink:PhenotypicFeature	Abnormal platelet phosphatidylserine exposure	An abnormality of phosphatidylserine (PS) on activated platelets. PS is normally located on the cytoplasmic face of the resting platelet membrane but appears on the plasma-oriented surface of discrete membrane vesicles that derive from activated platelets. Thrombin, the central molecule of coagulation, is produced from prothrombin by a complex (prothrombinase) between factor Xa and its protein cofactor (factor V(a)) that forms on platelet-derived membranes. This complex enhances the rate of activation of prothrombin to thrombin by roughly 150,000 fold relative to factor X(a) in solution. The negatively charged surface of PS-containing platelet-derived membranes is at least partly responsible for this rate enhancement.		hp.json		http://purl.obolibrary.org/obo/HP_0031131		
HP:0031132	biolink:PhenotypicFeature	Impaired annexin V binding to platelet phosphatidylserine	Reduced binding of annexin V to platelet membrane, which is mediated by exposed phosphatidylserine. This can be measured by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031132		
HP:0033793	biolink:PhenotypicFeature	Triggered by food ingestion	Applies to a sign or symptom that is provoked or brought about by eating a certain food.		hp.json		http://purl.obolibrary.org/obo/HP_0033793		
HP:0031137	biolink:PhenotypicFeature	Storage in hepatocytes	Hepatocytes (liver parenchymal cells) exhibit a bloated appearance because of expansion of the cytoplasm by accumulated material.		hp.json		http://purl.obolibrary.org/obo/HP_0031137		
HP:0033799	biolink:PhenotypicFeature	Abnormal circulating sex hormone concentration	Any deviation from the normal concentration of a sex hormone in the blood circulation		hp.json	Abnormal circulating gonadocorticoid concentration|Abnormal circulating sex steroid concentration|Abnormal circulating gonadal steroid concentration	http://purl.obolibrary.org/obo/HP_0033799		
HP:0031138	biolink:PhenotypicFeature	Abnormal B-type natriuretic peptide level	A deviation from the normal circulating concentration of B-type natriuretic peptide (BNP).		hp.json		http://purl.obolibrary.org/obo/HP_0031138		
HP:0031139	biolink:PhenotypicFeature	Frog-leg posture	A type of rest posture in an infant that indicated a generalized reduction in muscle tone. The hips are flexed and the legs are abducted to an extent that causes the lateral thigh to rest upon the supporting surface. This posture is said to resemble the legs of a frog.		hp.json		http://purl.obolibrary.org/obo/HP_0031139		
UBERON:0002412	biolink:AnatomicalEntity	vertebra	The ossified form of a vertebral element, a skeletal element that forms around the notochord and is part of the vertebral column.	TAO:0001189|UMLS:C0549207|MA:0000309|EMAPA:32740|FMA:9914|AAO:0000691|XAO:0004019|EFO:0001371|OpenCyc:Mx4rvt2Dh5wpEbGdrcN5Y29ycA|NCIT:C12933|ZFA:0001189|galen:Vertebra|CALOHA:TS-2352	hp.json	vertebra bone|vertebrae	http://purl.obolibrary.org/obo/UBERON_0002412		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0002411	biolink:AnatomicalEntity	clitoris	The small, erectile body located at the anterior end of the vulva.	EHDAA2:0000255|FMA:9909|MA:0000382|VHOG:0000700|EMAPA:30819|NCIT:C12308|galen:Clitoris|UMLS:C0008984|BTO:0002020|OpenCyc:Mx4rvVjr6ZwpEbGdrcN5Y29ycA|MESH:D002987|EHDAA:9360|GAID:385	hp.json		http://purl.obolibrary.org/obo/UBERON_0002411		pheno_slim|uberon_slim|organ_slim
UBERON:0002414	biolink:AnatomicalEntity	lumbar vertebra	Large vertebra of the movable part of the vertebral column, characterized by the absence of the foramen transversarium within the transverse process, and by the absence of facets on the sides of the body.	galen:LumbarVertebra|GAID:240|UMLS:C0024091|MESH:D008159|EMAPA:18007|FMA:9921|MA:0000312|CALOHA:TS-2364|NCIT:C12744|OpenCyc:Mx4rvaOek5wpEbGdrcN5Y29ycA	hp.json		http://purl.obolibrary.org/obo/UBERON_0002414		pheno_slim|uberon_slim
CHEBI:23229	biolink:ChemicalSubstance	chromanol	Any member of the class of chromanes that is chromane substituted by one or more hydroxy groups.		hp.json		http://purl.obolibrary.org/obo/CHEBI_23229		3_STAR
UBERON:0002413	biolink:AnatomicalEntity	cervical vertebra	A vertebra that is located in the cervical region of the vertebral column.	XAO:0003076|MESH:D002574|galen:CervicalVertebra|NCIT:C12693|FMA:9915|GAID:235|EMAPA:17674|MA:0000311	hp.json	cervical vertebrae|vertebrae cervicales	http://purl.obolibrary.org/obo/UBERON_0002413		pheno_slim|uberon_slim
PR:Q15465	biolink:Protein	sonic hedgehog protein (human)	A sonic hedgehog protein that is encoded in the genome of human.	UniProtKB:Q15465	hp.json	SHH|hSHH|Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains (human)|HHG-1 (human)|ShhNC (human)	http://purl.obolibrary.org/obo/PR_Q15465		
UBERON:0002410	biolink:AnatomicalEntity	autonomic nervous system	The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands[GO].	UMLS:C0004388|TAO:0001574|NCIT:C12673|GAID:706|Wikipedia:Autonomic_nervous_system|MESH:D001341|AAO:0000033|MA:0000219|FMA:65553|EHDA:10095|VHOG:0000396|EMAPA:16984|UMLS:C0004388|UMLS:C1305381|BIRNLEX:1123|EHDAA:3767|SCTID:362481007|BTO:0002507|CALOHA:TS-2001|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2054|ZFA:0001574|EHDAA2:0000158	hp.json	divisio autonomica systematis nervosi peripherici|autonomic part of peripheral nervous system|divisio autonomica systematis nervosi peripherici|peripheral autonomic nervous system|visceral nervous system|ANS|pars autonomica systematis nervosi peripherici|divisio autonomica systematis nervosi peripherici|autonomic division of peripheral nervous system	http://purl.obolibrary.org/obo/UBERON_0002410		pheno_slim|uberon_slim|vertebrate_core
PATO:0000642	biolink:NamedThing	fused with	A structural quality inhering in a bearer by virtue of the bearer's being merged with another entity.		hp.json	merged with|fused|fused to|joined with|coalesced	http://purl.obolibrary.org/obo/PATO_0000642		mpath_slim|relational_slim|value_slim
PATO:0000644	biolink:NamedThing	hyperplastic	A increased size quality inhering in an organ or tissue by virtue of the bearer's exhibiting increased number of cells.		hp.json	overdeveloped|hyperplasia	http://purl.obolibrary.org/obo/PATO_0000644		mpath_slim|value_slim
HP:0033721	biolink:PhenotypicFeature	EEG with centrotemporal epileptiform discharges	Focal epileptiform EEG discharges recorded in the centrotemporal region.		hp.json		http://purl.obolibrary.org/obo/HP_0033721		
PATO:0000643	biolink:NamedThing	herniated	A quality inhering in a bearer by virtue of the bearer's bodily structure that has protruded through an abnormal opening in the wall that contains it.		hp.json		http://purl.obolibrary.org/obo/PATO_0000643		mpath_slim|value_slim
HP:0033720	biolink:PhenotypicFeature	EEG with occipital epileptiform discharges	Focal epileptiform EEG discharges recorded in the occipital region.		hp.json		http://purl.obolibrary.org/obo/HP_0033720		
PATO:0000646	biolink:NamedThing	malformed	A morphological quality inhering in a bearer by virtue of the bearer's being distorted during formation.		hp.json	malformation	http://purl.obolibrary.org/obo/PATO_0000646		mpath_slim|value_slim
PATO:0000645	biolink:NamedThing	hypoplastic	A decreased size quality inhering in a bearer by virtue of the bearer's exhibiting reduced number of cells within an organ or tissue.		hp.json	hypoplasia|underdeveloped	http://purl.obolibrary.org/obo/PATO_0000645		mpath_slim|value_slim
PATO:0000648	biolink:NamedThing	obstructed	A morphological quality inhering in a bearer by virtue of the bearer's being blocked or filled with obstacles or an obstacle.		hp.json		http://purl.obolibrary.org/obo/PATO_0000648		mpath_slim|value_slim
PATO:0000647	biolink:NamedThing	necrotic	A structural quality inhering in a bearer by virtue of the bearer's undergoing unprogrammed cell death.		hp.json		http://purl.obolibrary.org/obo/PATO_0000647		mpath_slim|value_slim
HP:0033727	biolink:PhenotypicFeature	Diffuse lupus nephritis	A subclass of lupus nephritis with active or inactive diffuse, segmental or global endocapillary or extracapillary glomerulonephritis involving at least 50% of all glomeruli, typically with diffuse subendothelial immune deposits, with or without mesangial alterations.		hp.json	Class IV lupus nephritis	http://purl.obolibrary.org/obo/HP_0033727		
HP:0033726	biolink:PhenotypicFeature	Lupus nephritis	Lupus nephritis is a type of glomerulonephritis that constitutes one of the most severe organ manifestations of systemic lupus erythematosus. Lupus nephritis is subclassified in six distinct classes, that represent different manifestations and severities of renal involvement and guide the therapeutic management.		hp.json		http://purl.obolibrary.org/obo/HP_0033726		
GO:0010482	biolink:BiologicalProcess	regulation of epidermal cell division	Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis.		hp.json	regulation of hypodermal cell division	http://purl.obolibrary.org/obo/GO_0010482		
HP:0033729	biolink:PhenotypicFeature	Minimal mesangial lupus nephritis	A subclass of lupus nephritis with normal glomeruli by light microscopy, but mesangial immune deposits by immunofluorescence.		hp.json	Class I lupus nephritis	http://purl.obolibrary.org/obo/HP_0033729		
HP:0033728	biolink:PhenotypicFeature	Mesangial proliferative lupus nephritis	A subclass of lupus nephritis with purely mesangial hypercellularity of any degree or mesangial matrix expansion by lightmicroscopy, with mesangial immune deposits. A few isolated subepithelial or subendothelial deposits may be visible by immunoflourescence or electron microscopy, but not by light microscopy.		hp.json	Class II lupus nephritis	http://purl.obolibrary.org/obo/HP_0033728		
HP:0008756	biolink:PhenotypicFeature	Bowing of the vocal cords	Bowing (abnormal curvature) of the vocal folds.	UMLS:C0396064|SNOMEDCT_US:232448002	hp.json		http://purl.obolibrary.org/obo/HP_0008756		
HP:0033723	biolink:PhenotypicFeature	Abnormal cerebral venous sinus morphology	Abnormal structure of the venous sinuses that drain blood from the cerebral veins and cerebrospinal fluid (CSF) from the arachnoid granulations to the internal jugular veins.		hp.json	Abnormal dural venous sinus morphology|Abnormality of the cerebral venous sinuses	http://purl.obolibrary.org/obo/HP_0033723		
CHEBI:62803	biolink:ChemicalSubstance	fuel additive	Any additive that enhances the efficiency of fuel.		hp.json	fuel enhancer|fuel additives	http://purl.obolibrary.org/obo/CHEBI_62803		3_STAR
HP:0033722	biolink:PhenotypicFeature	Autonomic epileptic aura	An autonomic epileptic aura is a purely subjective manifestation of an epileptic seizure pertaining to autonomic nervous system function. Autonomic auras include cardiorespiratory (e.g., palpitations and shortness of breath), gastrointestinal, genitourinary (genital sensations, urinary urge), and cutaneous (feeling of warmth or cold) sensations. Abdominal auras constitute the most common type of autonomic aura. These include sensations of nausea, pain, or indescribable discomfort in the abdominal or periumbilical area that can be static, rise to the chest and throat, or descend into the lower abdominal region.		hp.json	Autonomic aura|Autonomic auras|Vegetative aura	http://purl.obolibrary.org/obo/HP_0033722		
HP:0008755	biolink:PhenotypicFeature	Laryngotracheomalacia		SNOMEDCT_US:308232009|UMLS:C0585984	hp.json		http://purl.obolibrary.org/obo/HP_0008755		
HP:0033725	biolink:PhenotypicFeature	Thin corpus callosum	An abnormally thin corpus callous, due to atrophy, hypoplasia or agenesis. This term is intended to be used in situations where it is not known if thinning of the corpus callosum (for instance, as visualized by magnetic resonance tomography) is due to abnormal development (e.g. a leukodystrophy) or atrophy following normal development (e.g. neurodegeneration).		hp.json	Thinning of the corpus callosum|Small corpus callosum	http://purl.obolibrary.org/obo/HP_0033725		
PATO:0000640	biolink:NamedThing	dysplastic	A structural quality inhering in a bearer by virtue of the bearer's exhibiting an alteration in size, shape or organization of its constituent cells.		hp.json	dysplasia	http://purl.obolibrary.org/obo/PATO_0000640		value_slim|mpath_slim
HP:0008757	biolink:PhenotypicFeature	Unilateral vocal cord paralysis	A loss of the ability to move the vocal fold on one side.	MSH:D014826|UMLS:C0751575	hp.json	Unilateral paralysis of the vocal cord	http://purl.obolibrary.org/obo/HP_0008757		
HP:0033724	biolink:PhenotypicFeature	Cerebral venous sinus thrombosis	An intracranial thrombosis of the venous sinuses. These typically present with headache, seizures or venous stroke secondary to raised cerebral venous pressure. Cerebral venous sinus thromboses usually affect larger areas of brain parenchyma than those affected by cerebral vein thromboses.		hp.json		http://purl.obolibrary.org/obo/HP_0033724		
HP:0008752	biolink:PhenotypicFeature	Laryngeal cartilage malformation	A malformation of the laryngeal cartilage.	UMLS:C4021530	hp.json	Vocal impairment, severe, due to laryngeal cartilage abnormalities	http://purl.obolibrary.org/obo/HP_0008752		
HP:0008751	biolink:PhenotypicFeature	Laryngeal cleft	Presence of a gap in the posterior laryngotracheal wall with a continuity between the larynx and the esopahagus.	SNOMEDCT_US:232461002|UMLS:C1840311|MSH:C537875	hp.json	Laryngotracheal cleft|Laryngotracheoesophageal cleft i	http://purl.obolibrary.org/obo/HP_0008751		
HP:0008754	biolink:PhenotypicFeature	Laryngeal calcification	Calcification (abnormal deposits of calcium) in the laryngeal tissues.	UMLS:C1859158	hp.json	Laryngeal calcifications	http://purl.obolibrary.org/obo/HP_0008754		
HP:0008753	biolink:PhenotypicFeature	Aplasia of the epiglottis	Absence of the epiglottis.	UMLS:C4024628	hp.json	Absent epiglottis	http://purl.obolibrary.org/obo/HP_0008753		
GO:0010481	biolink:BiologicalProcess	epidermal cell division	Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells.		hp.json	hypodermal cell division	http://purl.obolibrary.org/obo/GO_0010481		
HP:0008750	biolink:PhenotypicFeature	Laryngeal atresia	Congenital absence of the lumen of the larynx. Laryngeal atresia is a rare condition. If the laryngeal opening fails to develop, fluid secreted by the lungs cannot be expelled. In a fetus with laryngeal atresia, the lungs are either normal or hyperplastic, not hypoplastic. Mortality is reported as 100%. At obstetric US examination, views of the fetal neck demonstrate a dilated trachea filled with trapped fluid. Views of the fetal chest show enlarged, hyperechoic lungs, with dilated fluid-filled bronchi. Fetal ascites is usually present.	UMLS:C0265756|SNOMEDCT_US:64981002	hp.json		http://purl.obolibrary.org/obo/HP_0008750		
HP:0033730	biolink:PhenotypicFeature	Membranous lupus nephritis	A lupus nephritis subclass with global or segmental subepithelial immune deposits or their morphological sequelae by light microscopy and by immunofluorescence or electron microscopy, with or without mesangial alterations. May occur in combination with class III or IV, in which case both classes are diagnosed. May show advanced sclerosis		hp.json	Class V lupus nephritis	http://purl.obolibrary.org/obo/HP_0033730		
HP:0033732	biolink:PhenotypicFeature	Advanced sclerotic lupus nephritis	A subclass of lupus nephritis with at least 90% of glomeruli globally sclerosed without residual activity.		hp.json	Class VI lupus nephritis	http://purl.obolibrary.org/obo/HP_0033732		
HP:0033731	biolink:PhenotypicFeature	Focal lupus nephritis	A subclass of lupus nephritis with active or inactive focal, segmental or global endocapillary or extracapillary glomerulonephritis involving less than 50% of all glomeruli, typically with focal subendothelial immune deposits, with or without mesangial alterations		hp.json	Class III lupus nephritis	http://purl.obolibrary.org/obo/HP_0033731		
HP:0006108	biolink:PhenotypicFeature	Tapered metacarpals	Metacarpal that becomes thinner toward the distal end.	UMLS:C4025091	hp.json	Tapered long bones of hand	http://purl.obolibrary.org/obo/HP_0006108		
HP:0033738	biolink:PhenotypicFeature	Primary vesicoureteral reflux	Vesicoureteral reflux due to abnormalities in ureterovesical junction, e.g. ectopic insertion of the ureter or short intravesical tunnel at the ureterovesical junction.		hp.json		http://purl.obolibrary.org/obo/HP_0033738		
GO:0010496	biolink:BiologicalProcess	intercellular transport	The movement of substances between cells.		hp.json	single organism intercellular transport|single-organism intercellular transport	http://purl.obolibrary.org/obo/GO_0010496		
HP:0006109	biolink:PhenotypicFeature	Absent phalangeal crease	Absence of one or more interphalangeal creases (i.e., of the transverse lines in the skin between the phalanges of the fingers).	UMLS:C4020821|UMLS:C1862479	hp.json	Aplasia of the interphalangeal creases|Absent interphalangeal creases	http://purl.obolibrary.org/obo/HP_0006109		
HP:0033737	biolink:PhenotypicFeature	Grade III vesicoureteral reflux	Vesicoureteral reflux with dilatation of the collecting system.		hp.json	Grade III VUR|VUR III	http://purl.obolibrary.org/obo/HP_0033737		
HP:0033739	biolink:PhenotypicFeature	Secondary vesicoureteral reflux	Vesicoureteral reflux induced by increased bladder pressures in patients with voiding dysfunction e.g. in case of congenital posterior urethral valves or neurogenic bladder dysfunction.		hp.json		http://purl.obolibrary.org/obo/HP_0033739		
HP:0033734	biolink:PhenotypicFeature	High-grade vesicoureteral reflux	Vesicoureteral reflux with dilation of the renal calyces (Grade III - V).		hp.json		http://purl.obolibrary.org/obo/HP_0033734		
HP:0008767	biolink:PhenotypicFeature	Self-mutilation of tongue and lips due to involuntary movements		UMLS:C1860219	hp.json	Self-mutilation of tongue and lips due to involuntary movements	http://purl.obolibrary.org/obo/HP_0008767		
HP:0033733	biolink:PhenotypicFeature	Low-grade vesicoureteral reflux	Vesicoureteral reflux without dilation of the renal calyces (Grade I-II).		hp.json		http://purl.obolibrary.org/obo/HP_0033733		
PATO:0000651	biolink:NamedThing	unfused from	A structural quality inhering in a bearer by virtue of the bearer's being no longer merged with another entity.		hp.json	unfused	http://purl.obolibrary.org/obo/PATO_0000651		relational_slim|value_slim
HP:0033736	biolink:PhenotypicFeature	Grade II vesicoureteral reflux	Vesicoureteral reflux into a non-dilated pyelocalyceal system.		hp.json	VUR II|Grade II VUR	http://purl.obolibrary.org/obo/HP_0033736		
HP:0006106	biolink:PhenotypicFeature	Absent trapezoid bone		UMLS:C1847191	hp.json		http://purl.obolibrary.org/obo/HP_0006106		
HP:0033735	biolink:PhenotypicFeature	Grade I vesicoureteral reflux	Vesicoureteral reflux into the ureter only.		hp.json	Grade I VUR|VUR I	http://purl.obolibrary.org/obo/HP_0033735		
HP:0008768	biolink:PhenotypicFeature	Inappropriate sexual behavior		UMLS:C0474420|SNOMEDCT_US:248099006	hp.json	Inappropriate sexual behaviour|Inappropriate sexual behavior	http://purl.obolibrary.org/obo/HP_0008768		
HP:0006107	biolink:PhenotypicFeature	Fingerpad telangiectases	Telangiectasia (small dilated blood vessels) located in the fingerpads at the tips of the fingers.	UMLS:C1861248	hp.json	Small dilated blood vessels in fingerpads|Finger pad telangiectases	http://purl.obolibrary.org/obo/HP_0006107		
HP:0008763	biolink:PhenotypicFeature	No social interaction		UMLS:C1849683	hp.json	No social interaction	http://purl.obolibrary.org/obo/HP_0008763		
HP:0006101	biolink:PhenotypicFeature	Finger syndactyly	Webbing or fusion of the fingers, involving soft parts only or including bone structure. Bony fusions are referred to as "bony" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the fingers in a proximo-distal axis are referred to as "Symphalangism".	SNOMEDCT_US:34048007|SNOMEDCT_US:249769001|UMLS:C0221352|SNOMEDCT_US:268251006	hp.json	Partial syndactyly	http://purl.obolibrary.org/obo/HP_0006101		
HP:0008762	biolink:PhenotypicFeature	Repetitive compulsive behavior		UMLS:C1969697	hp.json	Repetitive compulsive behavior|Repetitive compulsive behaviour	http://purl.obolibrary.org/obo/HP_0008762		
HP:0008765	biolink:PhenotypicFeature	Auditory hallucinations	The false perception of sound.	SNOMEDCT_US:45150006|MSH:D006212|UMLS:C0233762	hp.json	Hearing sounds|Hallucinations of sound	http://purl.obolibrary.org/obo/HP_0008765		
HP:0008760	biolink:PhenotypicFeature	Violent behavior		UMLS:C0424323|SNOMEDCT_US:248004009	hp.json	Violent behavior|Violent behaviour	http://purl.obolibrary.org/obo/HP_0008760		
PR:O09100	biolink:Protein	endothelial transcription factor GATA-2 (mouse)	An endothelial transcription factor GATA-2 that is encoded in the genome of mouse.	UniProtKB:O09100	hp.json	Gata2|mGATA2|GATA-binding protein 2 (mouse)	http://purl.obolibrary.org/obo/PR_O09100		
HP:0033741	biolink:PhenotypicFeature	Grade IV vesicoureteral reflux	Vesicoureteral reflux with more-extensive dilation with blunting of the calyces and tortuosity of the ureter.		hp.json	VUR IV|Grade IV VUR	http://purl.obolibrary.org/obo/HP_0033741		
HP:0033740	biolink:PhenotypicFeature	Grade V vesicoureteral reflux	Vesicoureteral reflux with massive dilation of the collecting system and severe tortuosity of the ureter.		hp.json	Grade V VUR|VUR V	http://purl.obolibrary.org/obo/HP_0033740		
GO:0010468	biolink:BiologicalProcess	regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).	Wikipedia:Regulation_of_gene_expression	hp.json	regulation of protein expression|regulation of gene product expression|gene regulation	http://purl.obolibrary.org/obo/GO_0010468		
HP:0033743	biolink:PhenotypicFeature	Macular agenesis	A congenital defect characterized by lack of development of the macula.		hp.json		http://purl.obolibrary.org/obo/HP_0033743		
GO:0010469	biolink:BiologicalProcess	regulation of signaling receptor activity	Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity.		hp.json	regulation of receptor activity|regulation of signalling receptor activity	http://purl.obolibrary.org/obo/GO_0010469		
HP:0033742	biolink:PhenotypicFeature	Intrarenal reflux	Severe vesicoureteral reflux reaching the kidney parenchyma.		hp.json		http://purl.obolibrary.org/obo/HP_0033742		
PATO:0000665	biolink:NamedThing	high brightness	A color brightness which is relatively high.		hp.json	light	http://purl.obolibrary.org/obo/PATO_0000665		value_slim
HP:0033749	biolink:PhenotypicFeature	Abnormal functional residual capacity	A deviation from normal values for the functional residual capacity, which is defined as the volume remaining in the lungs after a normal, passive exhalation.		hp.json		http://purl.obolibrary.org/obo/HP_0033749		
HP:0008738	biolink:PhenotypicFeature	Partially duplicated kidney	The presence of a partially duplicated kidney.	UMLS:C4024630	hp.json	Partially duplicated kidney	http://purl.obolibrary.org/obo/HP_0008738		
GO:0010463	biolink:BiologicalProcess	mesenchymal cell proliferation	The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.		hp.json		http://purl.obolibrary.org/obo/GO_0010463		
HP:0033748	biolink:PhenotypicFeature	Hypoesthesia	Decreased ability to perceive touch.		hp.json	Numbness|Hypoaesthesia	http://purl.obolibrary.org/obo/HP_0033748		
HP:0008739	biolink:PhenotypicFeature	Labial pseudohypertrophy		UMLS:C1835380	hp.json		http://purl.obolibrary.org/obo/HP_0008739		
HP:0033745	biolink:PhenotypicFeature	Dysplasia of the superior cerebellar vermis			hp.json		http://purl.obolibrary.org/obo/HP_0033745		
GO:0034433	biolink:BiologicalProcess	steroid esterification	A lipid modification process in which a steroid ester is formed by the combination of a carboxylic acid (often a fatty acid) and a steroid molecule (e.g. cholesterol).		hp.json		http://purl.obolibrary.org/obo/GO_0034433		
HP:0008734	biolink:PhenotypicFeature	Decreased testicular size	Reduced volume of the testicle (the male gonad).	SNOMEDCT_US:276411001|UMLS:C0241355	hp.json	Decreased testicular size|Testicular hypoplasia|Hypoplastic testes|Small testes|Small testis	http://purl.obolibrary.org/obo/HP_0008734		
HP:0033744	biolink:PhenotypicFeature	Global cerebellar dysplasia			hp.json		http://purl.obolibrary.org/obo/HP_0033744		
GO:0010467	biolink:BiologicalProcess	gene expression	The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes.	Wikipedia:Gene_expression	hp.json		http://purl.obolibrary.org/obo/GO_0010467		goslim_flybase_ribbon
HP:0008733	biolink:PhenotypicFeature	Dysplastic testes		UMLS:C1837380	hp.json		http://purl.obolibrary.org/obo/HP_0008733		
GO:0034434	biolink:BiologicalProcess	sterol esterification	A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and a sterol molecule (e.g. cholesterol).		hp.json		http://purl.obolibrary.org/obo/GO_0034434		
GO:0010464	biolink:BiologicalProcess	regulation of mesenchymal cell proliferation	Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.		hp.json		http://purl.obolibrary.org/obo/GO_0010464		
HP:0033747	biolink:PhenotypicFeature	Abnormal exteroceptive sensation	A type of somatic sensory dysfunction characterized by abnormality of superficial sensation that is mediated by receptors in skin and mucous membranes.		hp.json		http://purl.obolibrary.org/obo/HP_0033747		
GO:0034435	biolink:BiologicalProcess	cholesterol esterification	A lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.		hp.json		http://purl.obolibrary.org/obo/GO_0034435		
HP:0008736	biolink:PhenotypicFeature	Hypoplasia of penis		SNOMEDCT_US:34911001|UMLS:C0266435	hp.json	Underdeveloped penis	http://purl.obolibrary.org/obo/HP_0008736		
GO:0034436	biolink:BiologicalProcess	glycoprotein transport	The directed movement of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0034436		
HP:0033746	biolink:PhenotypicFeature	Intrascapular pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the area between the shoulder blades.		hp.json	Pain between shoulder blades	http://purl.obolibrary.org/obo/HP_0033746		
HP:0008730	biolink:PhenotypicFeature	Female external genitalia in individual with 46,XY karyotype	The presence of female external genitalia in a person with a male karyotype.	UMLS:C1848178	hp.json	Males with female external genitalia	http://purl.obolibrary.org/obo/HP_0008730		
HP:0008732	biolink:PhenotypicFeature	Renal hypophosphatemia	Renal hypophosphatemia is defined as reduced serum phosphate (e.g., below 0.70 mmol/l) and an inappropriately high renal phosphate excretion.	UMLS:C4024631	hp.json		http://purl.obolibrary.org/obo/HP_0008732		
HP:0033752	biolink:PhenotypicFeature	Abnormal residual volume	Any deviation from normal values of the residual volume, which is defined as the volume of air left in the lungs at the end of maximal expiration (ie. the volume of air which you cannot voluntarily exhale from your lungs).		hp.json		http://purl.obolibrary.org/obo/HP_0033752		
HP:0033751	biolink:PhenotypicFeature	Elevated functional residual capacity	An abnormal increase in the volume remaining in the lungs after a normal, passive exhalation.		hp.json		http://purl.obolibrary.org/obo/HP_0033751		
HP:0033754	biolink:PhenotypicFeature	Abnormal left ventricular end-diastolic volume	Any deviation from the normal range of end-diastolic volume of the left ventricle, which is the volume of blood in the left ventricle at the end of diastole (just before systole).		hp.json		http://purl.obolibrary.org/obo/HP_0033754		
HP:0033753	biolink:PhenotypicFeature	Reduced residual volume	Abnormal decrease in the amount of air remaining in a person's lungs after full exhalation.		hp.json		http://purl.obolibrary.org/obo/HP_0033753		
HP:0033750	biolink:PhenotypicFeature	Reduced functional residual capacity	An abnormal reduction in the volume remaining in the lungs after a normal, passive exhalation.		hp.json		http://purl.obolibrary.org/obo/HP_0033750		
HP:0008749	biolink:PhenotypicFeature	Laryngeal hypoplasia	Underdevelopment of the larynx.	SNOMEDCT_US:253736003|UMLS:C0431527	hp.json	Hypoplastic larynx	http://purl.obolibrary.org/obo/HP_0008749		
HP:0033759	biolink:PhenotypicFeature	Impaired renal tubular reabsorption of magnesium	Decreased renal tubular reabsorption of magnesium.		hp.json		http://purl.obolibrary.org/obo/HP_0033759		
HP:0033756	biolink:PhenotypicFeature	Decreased left ventricular end-diastolic volume	Abnormally low volume of blood in the left ventricle at the end of diastole (just before systole).		hp.json		http://purl.obolibrary.org/obo/HP_0033756		
HP:0033755	biolink:PhenotypicFeature	Increased left ventricular end-diastolic volume	Abnormally high volume of blood in the left ventricle at the end of diastole (just before systole).		hp.json		http://purl.obolibrary.org/obo/HP_0033755		
HP:0008744	biolink:PhenotypicFeature	Abnormal aryepiglottic fold morphology	An abnormality of the aryepiglottic fold.	UMLS:C1849357	hp.json	Abnormal aryepiglottic folds|Abnormality of the aryepiglottic fold	http://purl.obolibrary.org/obo/HP_0008744		
HP:0033758	biolink:PhenotypicFeature	Labial abscess	A circumscribed area of pus or necrotic debris in the labia.		hp.json	Abscess of the labia	http://purl.obolibrary.org/obo/HP_0033758		
HP:0008747	biolink:PhenotypicFeature	Cartilaginous ossification of larynx	Ossification affecting the set of cartilages of larynx.	UMLS:C1855622	hp.json		http://purl.obolibrary.org/obo/HP_0008747		
HP:0033757	biolink:PhenotypicFeature	Pancreatic steatosis	Fat infiltration in the pancreas.		hp.json	Non-alcoholic fatty pancreatic disease|Pancreatic lipomatosis|Pancreatic fatty replacement|Pancreatic lipomatous pseudohypertrophy|Pancreatic fatty infiltration|Fatty pancreas	http://purl.obolibrary.org/obo/HP_0033757		
HP:0008740	biolink:PhenotypicFeature	Longitudinal vaginal septum	The presence of a longitudinal vaginal septum, thereby creating a vaginal duplication.	UMLS:C1841680	hp.json	Vertical vaginal septum	http://purl.obolibrary.org/obo/HP_0008740		
HP:0008743	biolink:PhenotypicFeature	Coronal hypospadias	A mild form of hypospadias in which the urethra opens just under the corona glandis.	UMLS:C4020787|SNOMEDCT_US:429641000124109|UMLS:C1394030	hp.json	Subcoronal hypospadias	http://purl.obolibrary.org/obo/HP_0008743		
HP:0008742	biolink:PhenotypicFeature	Prominent prostate median bar		UMLS:C4024629	hp.json		http://purl.obolibrary.org/obo/HP_0008742		
GO:0010470	biolink:BiologicalProcess	regulation of gastrulation	Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.		hp.json		http://purl.obolibrary.org/obo/GO_0010470		
OBO:MAXO_0001231	biolink:NamedThing	carnitine measurement	The determination of the amount of carnitine present in the sample.		hp.json	carnitine test|carnitine assessment	http://purl.obolibrary.org/obo/MAXO_0001231		
OBO:MAXO_0001230	biolink:NamedThing	folic acid measurement	The determination of the amount of folic acid present in the sample.		hp.json	folic acid test|folic acid assessment	http://purl.obolibrary.org/obo/MAXO_0001230		
PATO:0000608	biolink:NamedThing	closed	A morphological quality inhering in a bearer by virtue of the bearer's affording blocked passage or view.		hp.json	blocked	http://purl.obolibrary.org/obo/PATO_0000608		value_slim
OBO:MAXO_0001235	biolink:NamedThing	pyridoxal 5'-phosphate measurement	The determination of the amount of pyridoxal 5'-phosphate present in the sample.		hp.json	pyridoxal 5'-phosphate assessment|pyridoxal 5'-phosphate test	http://purl.obolibrary.org/obo/MAXO_0001235		
OBO:MAXO_0001234	biolink:NamedThing	phosphocholine measurement	The determination of the amount of phosphocholines present in the sample.		hp.json	phosphocholines test|phosphocholines assessment	http://purl.obolibrary.org/obo/MAXO_0001234		
PATO:0000609	biolink:NamedThing	closure incomplete	A morphological quality inhering in a bearer by virtue of the bearer's affording not completed blocked passage or view.		hp.json		http://purl.obolibrary.org/obo/PATO_0000609		value_slim
OBO:MAXO_0001233	biolink:NamedThing	glycerylphosphorylcholine measurement	The determination of the amount of glycerylphosphorylcholine present in the sample.		hp.json	glycerylphosphorylcholine assessment|glycerylphosphorylcholine test	http://purl.obolibrary.org/obo/MAXO_0001233		
OBO:MAXO_0001232	biolink:NamedThing	choline measurement	The determination of the amount of choline present in the sample.		hp.json	choline test|choline assessment	http://purl.obolibrary.org/obo/MAXO_0001232		
CHEBI:132966	biolink:ChemicalSubstance	hippurate	An N-acylglycinate obtained by deprotonation of the carboxy group of hippuric acid (N-benzoylglycine) and its derivatives.		hp.json	N-benzoylglycine anions|N-benzoylglycinate|N-benzoylglycinates|N-benzoylglycine anion|hippurates	http://purl.obolibrary.org/obo/CHEBI_132966		3_STAR
PATO:0000600	biolink:NamedThing	increased width	A width which is relatively large.		hp.json	wide/broad|wide|broad	http://purl.obolibrary.org/obo/PATO_0000600		value_slim
CHEBI:59266	biolink:ChemicalSubstance	amino trisaccharide	An amino oligosaccharide that is a trisaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.		hp.json	amino trisaccharides	http://purl.obolibrary.org/obo/CHEBI_59266		3_STAR
CHEBI:132961	biolink:ChemicalSubstance	methylsuccinate	A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 3-methylsuccinic acid.		hp.json	methylsuccinic acid anions|methylsuccinic acid anion|methylsuccinate anion|methylsuccinates|2-methylbutanedioic acid anion|2-methylbutanedioic acid anions	http://purl.obolibrary.org/obo/CHEBI_132961		3_STAR
HP:0008796	biolink:PhenotypicFeature	Femoral retroversion	An abnormal backward rotation of the hip relative to the knee such that the hips are externally rotated with the foot pointed outward instead of straight ahead (out-toeing).	UMLS:C1846339	hp.json	Decreased femoral torsion|Externally rotated hips	http://purl.obolibrary.org/obo/HP_0008796		
OBO:MAXO_0001239	biolink:NamedThing	vitamin B complex measurement	The determination of the amount of vitamin B complex present in the sample.		hp.json	vitamin B complex test|vitamin B complex assessment	http://purl.obolibrary.org/obo/MAXO_0001239		
OBO:MAXO_0001238	biolink:NamedThing	vitamin B measurement	The determination of the amount of B vitamin present in the sample.		hp.json	B vitamin test|B vitamin assessment	http://purl.obolibrary.org/obo/MAXO_0001238		
HP:0006134	biolink:PhenotypicFeature	Enlarged metacarpal epiphyses	Abnormally large size of one or more growth plates (epiphyses) of the metacarpal bones (i.e., the tubular bones of the hand between the carpus and the phalanges).	UMLS:C1865035	hp.json	Enlarged end part of long bone of hand	http://purl.obolibrary.org/obo/HP_0006134		
HP:0008798	biolink:PhenotypicFeature	Widened greater sciatic notch	The sacroiliac joint in the bony pelvis connects the sacrum and the ilium of the pelvis, which are joined by strong ligaments. The notch is located directly superior to the joint. This term refers to a increase in the lateral dimension of the notch.	UMLS:C4024620	hp.json	Widening of the sacrosciatic notch|Widened sacrosciatic notch	http://purl.obolibrary.org/obo/HP_0008798		
OBO:MAXO_0001237	biolink:NamedThing	vitamin A measurement	The determination of the amount of vitamin A present in the sample.		hp.json	vitamin A test|vitamin A assessment	http://purl.obolibrary.org/obo/MAXO_0001237		
HP:0006135	biolink:PhenotypicFeature	Decreased finger mobility		UMLS:C1862133	hp.json	Decreased finger mobility|Decreased finger movement	http://purl.obolibrary.org/obo/HP_0006135		
HP:0008797	biolink:PhenotypicFeature	Early ossification of capital femoral epiphyses	Developmental acceleration of ossification of the proximal epiphysis of the femur.	UMLS:C4024621	hp.json		http://purl.obolibrary.org/obo/HP_0008797		
OBO:MAXO_0001236	biolink:NamedThing	chemical measurement	The determination of the amount of chemical entity present in the sample.		hp.json	chemical entity test|chemical entity assessment	http://purl.obolibrary.org/obo/MAXO_0001236		
HP:0006136	biolink:PhenotypicFeature	Bilateral postaxial polydactyly		UMLS:C1855003	hp.json		http://purl.obolibrary.org/obo/HP_0006136		
HP:0008794	biolink:PhenotypicFeature	Dysplastic iliac wing	A general term that describes a congenital defect in the iliac wing resulting from abnormal development.	UMLS:C1837487	hp.json	Dysplastic iliac wings	http://purl.obolibrary.org/obo/HP_0008794		
PATO:0000617	biolink:NamedThing	bent	A shape quality inhering in a bearer by virtue of the bearer's having one or more angle(s) in its length.		hp.json	flexed|angled	http://purl.obolibrary.org/obo/PATO_0000617		value_slim
PATO:0000616	biolink:NamedThing	asymmetrical	A symmetry quality inhering in a bearer by virtue of the bearer's lacking symmetry.		hp.json	asymmetric|asymmetry	http://purl.obolibrary.org/obo/PATO_0000616		value_slim|mpath_slim|cell_quality
PATO:0000619	biolink:NamedThing	crowded	A positional quality inhering in a bearer by virtue of the bearer's being overfilled.		hp.json		http://purl.obolibrary.org/obo/PATO_0000619		value_slim
PATO:0000618	biolink:NamedThing	bilateral	A positional quality inhering in a bearer by virtue of the bearer's having two sides; two-sided.		hp.json		http://purl.obolibrary.org/obo/PATO_0000618		value_slim|mpath_slim
HP:0006150	biolink:PhenotypicFeature	Swan neck-like deformities of the fingers	A swan neck deformity describes a finger with a hyperextended PIP joint and a flexed DIP joint. The most common cause for a swan neck-like deformity is a disruption of the end of the extensor tendon. Conditions that loosen the PIP joint and allow it to hyperextend, for example conditions that weaken the volar plate, can produce a swan neck deformity of the finger. One example is rheumatoid arthritis. Another cause are conditions that tighten up the small (intrinsic) muscles of the hand and fingers, for example hand trauma or nerve disorders, such as cerebral palsy, Parkinson's disease, or stroke.	UMLS:C1849152	hp.json		http://purl.obolibrary.org/obo/HP_0006150		
OBO:MAXO_0001222	biolink:NamedThing	serum alpha-fetoprotein measurement	The determination of the amount of alpha-fetoprotein present in blood serum.		hp.json	blood serum alpha-fetoprotein (human) test|alpha-fetoprotein (human) blood serum assessment|serum alpha-fetoprotein test|alpha-fetoprotein serum measurement	http://purl.obolibrary.org/obo/MAXO_0001222		
PATO:0000610	biolink:NamedThing	open	A morphological quality inhering in a bearer by virtue of the bearer's affording unobstructed passage or view.		hp.json		http://purl.obolibrary.org/obo/PATO_0000610		value_slim
PATO:0000614	biolink:NamedThing	oriented	A pattern where all the repeated elements are oriented in the same direction.		hp.json		http://purl.obolibrary.org/obo/PATO_0000614		value_slim
CHEBI:132970	biolink:ChemicalSubstance	5-ammoniolevulinic acid	A primary ammonium ion obtained by protonation of the amino group of 5-aminolevulinic acid.		hp.json	5-aminolevulinic acid(1+)|5-aminolevulinic acid cation|4-carboxy-2-oxobutan-1-aminium	http://purl.obolibrary.org/obo/CHEBI_132970		3_STAR
GO:0010455	biolink:BiologicalProcess	positive regulation of cell fate commitment	Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.		hp.json		http://purl.obolibrary.org/obo/GO_0010455		
CHEBI:59252	biolink:ChemicalSubstance	linear tetrapyrrole anion	An organic anion arising from deprotonation of a acyclic tetrapyrrole compound.		hp.json	linear tetrapyrrole anions|acyclic tetrapyrrole anion|acyclic tetrapyrrole anions	http://purl.obolibrary.org/obo/CHEBI_59252		3_STAR
HP:0006149	biolink:PhenotypicFeature	Increased laxity of fingers		UMLS:C1850855	hp.json		http://purl.obolibrary.org/obo/HP_0006149		
GO:0010453	biolink:BiologicalProcess	regulation of cell fate commitment	Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.		hp.json		http://purl.obolibrary.org/obo/GO_0010453		
GO:0010454	biolink:BiologicalProcess	negative regulation of cell fate commitment	Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.		hp.json		http://purl.obolibrary.org/obo/GO_0010454		
HP:0006144	biolink:PhenotypicFeature	Shortening of all proximal phalanges of the fingers	Congenital hypoplasia of proximal phalanx of finger or all fingers.	UMLS:C4025089	hp.json	Shortening of all innermost bones of the fingers	http://purl.obolibrary.org/obo/HP_0006144		
OBO:MAXO_0001228	biolink:NamedThing	creatine measurement	The determination of the amount of creatine present in the sample.		hp.json	creatine assessment|creatine test	http://purl.obolibrary.org/obo/MAXO_0001228		
OBO:MAXO_0001227	biolink:NamedThing	beta carotene measurement	The determination of the amount of beta-caroteneβ-carotene present in the sample.		hp.json	beta-caroteneβ-carotene test|beta-caroteneβ-carotene assessment|beta-carotene test|beta carotene assessment|beta-carotene measurement|b-carotene measurement	http://purl.obolibrary.org/obo/MAXO_0001227		
HP:0006145	biolink:PhenotypicFeature	Central Y-shaped metacarpal	A central Y-shaped metacarpal is the result of a partial fusion of two central metacarpals (i.e., metacarpals 2-4) of the hand, with the two arms of the Y pointing in the distal direction. Central Y-shaped metacarpals may be seen as a result of a central polydactyly with partial fusion of the duplicated metacarpal.	UMLS:C1848597	hp.json	Y-shaped central long bones of hand	http://purl.obolibrary.org/obo/HP_0006145		
HP:0006146	biolink:PhenotypicFeature	Broad metacarpal epiphyses	Increased side-to-side width of the metacarpal epiphyses.	UMLS:C4025088	hp.json	Broad end part of long bone of hand	http://purl.obolibrary.org/obo/HP_0006146		
HP:0006147	biolink:PhenotypicFeature	Progressive fusion 2nd-5th pip joints		UMLS:C1861310	hp.json		http://purl.obolibrary.org/obo/HP_0006147		
HP:0006140	biolink:PhenotypicFeature	Premature fusion of phalangeal epiphyses	Fusion of the epiphysis and metaphysis of one or more phalanges prior to the normal age or stage of growth.	UMLS:C1855620	hp.json	Premature fusion of end part of digital bone	http://purl.obolibrary.org/obo/HP_0006140		
HP:0006143	biolink:PhenotypicFeature	Abnormal finger flexion creases		UMLS:C1859481	hp.json		http://purl.obolibrary.org/obo/HP_0006143		
OBO:MAXO_0001229	biolink:NamedThing	phosphocreatine measurement	The determination of the amount of N-phosphocreatine present in the sample.		hp.json	N-phosphocreatine test|N-phosphocreatine assessment	http://purl.obolibrary.org/obo/MAXO_0001229		
OBO:MAXO_0001253	biolink:NamedThing	pelvic radiograph procedure	Use of an imaging test that uses small amounts of radiation to produce pictures of pelvic region of trunk.		hp.json	radiography of pelvic region of trunk|pelvic radiogram procedure|radiograph of pelvic region of trunk|pelvis radiograph|pelvic region of trunk X-ray procedure|X-ray of the pelvis|radiograph of pelvis|pelvic region of trunk radiogram procedure	http://purl.obolibrary.org/obo/MAXO_0001253		
PATO:0000628	biolink:NamedThing	mislocalised	A positional quality inhering in a bearer by virtue the bearer's being changed in abnormal position.		hp.json	mislocalized|ectopic	http://purl.obolibrary.org/obo/PATO_0000628		disposition_slim|value_slim
OBO:MAXO_0001252	biolink:NamedThing	folate measurement	The determination of the amount of folates present in the sample.		hp.json	folates assessment|folates test	http://purl.obolibrary.org/obo/MAXO_0001252		
PATO:0000627	biolink:NamedThing	localized	A spatial pattern quality inhering in a bearer by virtue of the bearer's being confined or restricted to a particular location.		hp.json	focal|localised	http://purl.obolibrary.org/obo/PATO_0000627		value_slim|mpath_slim|hpo_slim
OBO:MAXO_0001251	biolink:NamedThing	vitamin K measurement	The determination of the amount of vitamin K present in the sample.		hp.json	vitamin K assessment|vitamin K test	http://purl.obolibrary.org/obo/MAXO_0001251		
OBO:MAXO_0001250	biolink:NamedThing	vitamin E measurement	The determination of the amount of vitamin E present in the sample.		hp.json	vitamin E assessment|vitamin E test	http://purl.obolibrary.org/obo/MAXO_0001250		
GO:0022411	biolink:BiologicalProcess	cellular component disassembly	A cellular process that results in the breakdown of a cellular component.		hp.json	cellular component disassembly at cellular level|cell structure disassembly	http://purl.obolibrary.org/obo/GO_0022411		goslim_pir
GO:0022410	biolink:BiologicalProcess	circadian sleep/wake cycle process	A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.		hp.json		http://purl.obolibrary.org/obo/GO_0022410		
OBO:MAXO_0001254	biolink:NamedThing	skull radiograph procedure	Use of an imaging test that uses small amounts of radiation to produce pictures of skull.		hp.json	radiograph of skull|X-ray of the skull|radiography of skull|skull X-ray procedure|skull radiogram procedure	http://purl.obolibrary.org/obo/MAXO_0001254		
GO:0022412	biolink:BiologicalProcess	cellular process involved in reproduction in multicellular organism	A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.		hp.json	reproductive cellular process in multicellular organism	http://purl.obolibrary.org/obo/GO_0022412		
CHEBI:132943	biolink:ChemicalSubstance	aspartate			hp.json		http://purl.obolibrary.org/obo/CHEBI_132943		1_STAR
PATO:0000623	biolink:NamedThing	exserted	A quality inhering in a bearer by virtue of the bearer's protruding or projecting from the body.		hp.json	prolapsed|prolapse	http://purl.obolibrary.org/obo/PATO_0000623		value_slim
PATO:0000625	biolink:NamedThing	inverted	An oriented quality inhering in a bearer by virtue of the bearer's being reversed in position, order, or condition.		hp.json	backward|reversed	http://purl.obolibrary.org/obo/PATO_0000625		value_slim|mpath_slim
HP:0033705	biolink:PhenotypicFeature	Tearfulness	A feeling of sadness characterized by crying episodes that can come on suddenly and are not under usual social control.		hp.json		http://purl.obolibrary.org/obo/HP_0033705		
HP:0006119	biolink:PhenotypicFeature	Proximal tapering of metacarpals	Some or all of the metacarpal bones (i.e., metacarpal II to V) have a pointed proximal appearance.	UMLS:C1854749	hp.json	Pointed innermost long bone of hand|Pointed proximal metacarpals	http://purl.obolibrary.org/obo/HP_0006119		hposlim_core
HP:0033704	biolink:PhenotypicFeature	Elevated urinary homogentisic acid	An increased amount of homogentisic acid in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0033704		
HP:0033707	biolink:PhenotypicFeature	Perioral hyperkeratosis	Increased thickness of the stratum corneum (the outer layer of the skin) in the skin surrounding the mouth.		hp.json		http://purl.obolibrary.org/obo/HP_0033707		
HP:0033706	biolink:PhenotypicFeature	Progressive massive fibrosis	This condition is caused by slow-growing conglomeration of dust particles and collagen deposition in individuals (mostly coal workers) heavily exposed to inorganic dust. Progressive massive fibrosis manifests as masslike lesions, usually bilateral and in the upper lobes. Background nodular opacities reflect accompanying pneumoconiosis, with or without emphysematous destruction adjacent to the massive fibrosis. Lesions similar to progressive massive fibrosis sometimes occur in other conditions, such as sarcoidosis and talcosis.		hp.json		http://purl.obolibrary.org/obo/HP_0033706		
HP:0033701	biolink:PhenotypicFeature	Cortical sclerosis of the iliac wing	Increased density related to increased bone mass in the outermost layer (edge) of the iliac wing.		hp.json		http://purl.obolibrary.org/obo/HP_0033701		
CHEBI:62868	biolink:ChemicalSubstance	hepatoprotective agent	Any compound that is able to prevent damage to the liver.		hp.json	antihepatotoxic agent|hepatoprotective agents|hepatoprotector	http://purl.obolibrary.org/obo/CHEBI_62868		3_STAR
HP:0008777	biolink:PhenotypicFeature	Abnormal vocal cord morphology	An abnormality of the vocal cord.	UMLS:C0262665	hp.json	Abnormality of the vocal cords	http://purl.obolibrary.org/obo/HP_0008777		
HP:0033700	biolink:PhenotypicFeature	Papulovesicular eruption	An acute onset rash characterized by by multiple vesicles, which are circumscribed, fluid-containing, epidermal elevations with a diameter less than 10mm at the widest point, and by multiple papules, which are circumscribed, solid epidermal elevations with no visible fluid with a diameter less than 10mm at the widest point.		hp.json	Papulo-vesicular eruption	http://purl.obolibrary.org/obo/HP_0033700		
HP:0033703	biolink:PhenotypicFeature	Dysembryoplastic neuroepithelial tumor	Dysembryoplastic neuroepithelial tumor (DNT) is a benign glioneuronal neoplasm that most commonly occurs in children and young adults and may present with medically intractable, chronic seizures. Lesions vary in size from 10 to 25 mm, although occasionally larger tumors of up to 70 mm have been reported. Grossly, tumors appear as well-defined, solitary nodular masses or poorly demarcated lesions. On the cut section, most tumors are cortically located and may extend into the underlying subcortical white matter in larger tumors. Multi-nodular appearance or cystic changes are commonly found		hp.json	DNT|DNET	http://purl.obolibrary.org/obo/HP_0033703		
CHEBI:132941	biolink:ChemicalSubstance	2-hydroxyglutarate	A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of 2-hydroxyglutaric acid.		hp.json	2-hydroxyglutaric acid anion|2-hydroxyglutarate anion	http://purl.obolibrary.org/obo/CHEBI_132941		3_STAR
HP:0033702	biolink:PhenotypicFeature	Subpleural curvilinear line	This finding is a thin curvilinear opacity, 1-3 mm in thickness, lying less than 1 cm from and parallel to the pleural surface. It corresponds to atelectasis of normal lung if seen in the dependent posteroinferior portion of lung of a patient in the supine position and is subsequently shown to disappear on CT sections acquired with the patient prone. It may also be encountered in patients with pulmonary edema or fibrosis (other signs are usually present).		hp.json		http://purl.obolibrary.org/obo/HP_0033702		
HP:0006118	biolink:PhenotypicFeature	Shortening of all distal phalanges of the fingers	Hypoplasia of all of the distal phalanx of finger.	UMLS:C4021608	hp.json	Shortening of all outermost bones of the fingers|Brachytelephalangy	http://purl.obolibrary.org/obo/HP_0006118		
HP:0008774	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the inner ear	Aplasia or developmental hypoplasia of the inner ear.	UMLS:C4024625	hp.json	Absent/underdeveloped inner ear|Absent/small inner ear	http://purl.obolibrary.org/obo/HP_0008774		
GO:0009437	biolink:BiologicalProcess	carnitine metabolic process	The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.		hp.json	carnitine metabolism|vitamin Bt metabolism|vitamin Bt metabolic process	http://purl.obolibrary.org/obo/GO_0009437		
HP:0008773	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the middle ear	Aplasia or developmental hypoplasia of all or part of the middle ear.	UMLS:C4021529	hp.json	Absent/underdeveloped middle ear|Middle ear hypoplasia/aplasia|Hypoplastic/aplastic middle ear structures|Absent/small middle ear	http://purl.obolibrary.org/obo/HP_0008773		
HP:0006112	biolink:PhenotypicFeature	Expanded phalanges with widened medullary cavities		UMLS:C1969287	hp.json		http://purl.obolibrary.org/obo/HP_0006112		
GO:0009438	biolink:BiologicalProcess	methylglyoxal metabolic process	The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.	MetaCyc:METHGLYUT-PWY	hp.json	methylglyoxal pathway|methylglyoxal bypass|methylglyoxal metabolism	http://purl.obolibrary.org/obo/GO_0009438		
GO:0022414	biolink:BiologicalProcess	reproductive process	A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.		hp.json	single organism reproductive process	http://purl.obolibrary.org/obo/GO_0022414		goslim_generic
HP:0008776	biolink:PhenotypicFeature	Abnormal renal artery morphology	Any structural abnormality of the renal artery.	UMLS:C4024624	hp.json	Abnormality of the renal artery|Abnormal kidney artery	http://purl.obolibrary.org/obo/HP_0008776		
HP:0006114	biolink:PhenotypicFeature	Multiple palmar creases	The presence of multiple creases on the palm of the hand (more than the normal three major creases (distal transverse crease, proximal transverse crease, and thenar crease).	UMLS:C1861872	hp.json	Multiple palm lines	http://purl.obolibrary.org/obo/HP_0006114		
HP:0008775	biolink:PhenotypicFeature	Abnormal prostate morphology	An abnormality of the prostate.	UMLS:C0747987	hp.json	Abnormality of the prostate	http://purl.obolibrary.org/obo/HP_0008775		
HP:0008770	biolink:PhenotypicFeature	Obsessive-compulsive trait	The presence of one or more obsessive-compulsive personality traits. Obsessions refer to persistent intrusive thoughts, and compulsions to intrusive behaviors, which the affected person experiences as involuntary, senseless, or repugnant.	UMLS:C1834433	hp.json	Obsessive-compulsive trait|Obsessive-compulsive traits	http://purl.obolibrary.org/obo/HP_0008770		
HP:0033709	biolink:PhenotypicFeature	Increased sputum production	An increase in the amount of airway mucus. This feature may be characterized by frequent or excessive throat clearing (exhalation through tightly constricted laryngopharyngeal tissues accompanied by vibration of the palatoglossal arch and the vocal folds serving to clear mucus from the airway).		hp.json	Increased phlegm	http://purl.obolibrary.org/obo/HP_0033709		
CHEBI:35274	biolink:ChemicalSubstance	ammonium ion derivative	A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc).		hp.json	azanium ion derivatives|ammonium ion derivatives|azanium ion derivative	http://purl.obolibrary.org/obo/CHEBI_35274		3_STAR
HP:0033708	biolink:PhenotypicFeature	Anti-3-hydroxy- 3-methylglutaryl-coA reductase antibody positivity			hp.json	Anti-HMGCR autoantibodies|Anti-3-hydroxy- 3-methylglutaryl-coA reductase antibodies	http://purl.obolibrary.org/obo/HP_0033708		
HP:0008772	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the external ear	The presence of aplasia or developmental hypoplasia of all or part of the external ear.	UMLS:C4024626	hp.json	Absent/underdeveloped external ear|Absent/small external ear	http://purl.obolibrary.org/obo/HP_0008772		
HP:0008771	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the ear	The presence of aplasia or developmental hypoplasia of the ear.	UMLS:C4024627	hp.json	Absent/small ear|Absent/underdeveloped ear	http://purl.obolibrary.org/obo/HP_0008771		
HP:0006110	biolink:PhenotypicFeature	Shortening of all middle phalanges of the fingers	Short, hypoplastic middle phalanx of finger, affecting all fingers.	UMLS:C1856912	hp.json		http://purl.obolibrary.org/obo/HP_0006110		
PATO:0000639	biolink:NamedThing	degenerate	A structural quality inhering in a bearer whose structure deteriorates or is lost over time due to an active pathological process.		hp.json	degeneration	http://purl.obolibrary.org/obo/PATO_0000639		value_slim|mpath_slim
OBO:MAXO_0001242	biolink:NamedThing	vitamin B3 measurement	The determination of the amount of vitamin B3 present in the sample.		hp.json	niacin measurement|vitamin B3 test|vitamin B3 assessment	http://purl.obolibrary.org/obo/MAXO_0001242		
OBO:MAXO_0001241	biolink:NamedThing	vitamin B2 measurement	The determination of the amount of vitamin B2 present in the sample.		hp.json	riboflavin measurement|vitamin B2 test|vitamin B2 assessment	http://purl.obolibrary.org/obo/MAXO_0001241		
OBO:MAXO_0001240	biolink:NamedThing	vitamin B1 measurement	The determination of the amount of vitamin B1 present in the sample.		hp.json	vitamin B1 test|vitamin B1 assessment|thiamin measurement	http://purl.obolibrary.org/obo/MAXO_0001240		
OBO:MAXO_0001246	biolink:NamedThing	vitamin B9 measurement	The determination of the amount of vitamin B9 present in the sample.		hp.json	vitamin B9 test|vitamin B9 assessment	http://purl.obolibrary.org/obo/MAXO_0001246		
OBO:MAXO_0001245	biolink:NamedThing	vitamin B7 measurement	The determination of the amount of vitamin B7 present in the sample.		hp.json	vitamin B7 test|vitamin B7 assessment	http://purl.obolibrary.org/obo/MAXO_0001245		
OBO:MAXO_0001244	biolink:NamedThing	vitamin B6 measurement	The determination of the amount of vitamin B6 present in the sample.		hp.json	vitamin B6 assessment|vitamin B6 test	http://purl.obolibrary.org/obo/MAXO_0001244		
GO:0022402	biolink:BiologicalProcess	cell cycle process	The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.		hp.json		http://purl.obolibrary.org/obo/GO_0022402		gocheck_do_not_annotate
OBO:MAXO_0001243	biolink:NamedThing	vitamin B5 measurement	The determination of the amount of vitamin B5 present in the sample.		hp.json	vitamin B5 assessment|vitamin B5 test	http://purl.obolibrary.org/obo/MAXO_0001243		
CHEBI:132954	biolink:ChemicalSubstance	sebacate	A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of sebacic acid.		hp.json	sebacic acid anion|sebacate anion|decanedioic acid anion|decanedioic acid anions|sebacate anions|sebacic acid anions|sebacates	http://purl.obolibrary.org/obo/CHEBI_132954		3_STAR
HP:0033710	biolink:PhenotypicFeature	Rest dyspnea	A perception of shortness of breath that occurs independently of exertion.		hp.json	Breathlessness at rest|Dyspnoea at rest|Dyspnea at rest|Shortness of breath at rest	http://purl.obolibrary.org/obo/HP_0033710		
PATO:0000632	biolink:NamedThing	symmetrical	A symmetry quality inhering in a bearer by virtue of the bearer's being capable of division by a longitudinal plane into similar halves.		hp.json	symmetric	http://purl.obolibrary.org/obo/PATO_0000632		mpath_slim|cell_quality|value_slim
PATO:0000635	biolink:NamedThing	unlocalised	A spatial pattern inhering in a bearer by virtue of the bearer's not being confined or restricted to a particular location.		hp.json		http://purl.obolibrary.org/obo/PATO_0000635		mpath_slim|value_slim
PATO:0000634	biolink:NamedThing	unilateral	A spatial pattern inhering in a bearer by virtue of the bearer's involvement of only one part or side.		hp.json		http://purl.obolibrary.org/obo/PATO_0000634		mpath_slim|value_slim
HP:0033716	biolink:PhenotypicFeature	EEG with frontal epileptiform discharges	Focal epileptiform EEG discharges recorded in the frontal region.		hp.json		http://purl.obolibrary.org/obo/HP_0033716		
HP:0033715	biolink:PhenotypicFeature	Hippocampal sclerosis	Atrophy with gliosis of the hippocampus with loss of neurons and the normal cortical architecture.		hp.json	Mesial temporal sclerosis	http://purl.obolibrary.org/obo/HP_0033715		
HP:0033718	biolink:PhenotypicFeature	EEG with central epileptiform discharges	Focal epileptiform EEG discharges recorded in the central region.		hp.json		http://purl.obolibrary.org/obo/HP_0033718		
HP:0033717	biolink:PhenotypicFeature	EEG with temporal epileptiform discharges	Focal epileptiform EEG discharges recorded in the temporal region.		hp.json		http://purl.obolibrary.org/obo/HP_0033717		
HP:0008789	biolink:PhenotypicFeature	Cone-shaped capital femoral epiphysis	A cone-shaped deformity of the proximal epiphysis of the femur.	UMLS:C1846157	hp.json	Cone-shaped end part of innermost thighbone	http://purl.obolibrary.org/obo/HP_0008789		
HP:0033712	biolink:PhenotypicFeature	Repeated implantation failure	Repeated implantation failure refers to a situation in which embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles.		hp.json	Recurrent implantation failure	http://purl.obolibrary.org/obo/HP_0033712		
HP:0033711	biolink:PhenotypicFeature	Pulmonary interstitial thickening	Pathological thickening of the pulmonary interstitium visualized radiographically and divided into interlobular and intralobular septal thickening.		hp.json		http://purl.obolibrary.org/obo/HP_0033711		
HP:0008788	biolink:PhenotypicFeature	Delayed pubic bone ossification	Delayed maturation and calcification of the pubic bone.	UMLS:C1861528|UMLS:C1866710|UMLS:C4280411	hp.json	Delayed mineralization of pubic bone|Delayed maturation fo pubic bone|Absent pubic ossification in infancy	http://purl.obolibrary.org/obo/HP_0008788		hposlim_core
HP:0006127	biolink:PhenotypicFeature	Long proximal phalanx of finger	Increased length of the proximal phalanx of finger.	UMLS:C4025090	hp.json	Long innermost finger bone	http://purl.obolibrary.org/obo/HP_0006127		
HP:0033714	biolink:PhenotypicFeature	Multiple meningiomas	The occurrence of multiple distinct meningiomas in the same individual.		hp.json	Multifocal meningiomata|Multiple meningiomata	http://purl.obolibrary.org/obo/HP_0033714		
HP:0006129	biolink:PhenotypicFeature	Drumstick terminal phalanges	Rounding and broadening of the tufts of the distal phalanges.	UMLS:C1844822	hp.json	Drumstick shaped digital bones	http://purl.obolibrary.org/obo/HP_0006129		
HP:0033713	biolink:PhenotypicFeature	Anti-signal recognition particle antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react against anti-signal recognition particle.		hp.json	Anti-SRP antibody positivity	http://purl.obolibrary.org/obo/HP_0033713		
CHEBI:132952	biolink:ChemicalSubstance	oxalate	A dicarboxylic acid anion obtained by deprotonation of at least one of the carboxy groups of oxalic acid.		hp.json	oxalate anions|oxalic acid anion|oxalic acid anions|oxalate anion|oxalates|ethanedioic acid anion|ethanedioic acid anions	http://purl.obolibrary.org/obo/CHEBI_132952		3_STAR
CHEBI:35281	biolink:ChemicalSubstance	onium betaine	Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.		hp.json	betaines|onium betaines	http://purl.obolibrary.org/obo/CHEBI_35281		3_STAR
HP:0008785	biolink:PhenotypicFeature	Delayed ossification of pubic rami	Delayed maturation and calcification of the rami (branches) of the pubic bone.	UMLS:C1865363	hp.json		http://purl.obolibrary.org/obo/HP_0008785		
GO:0022403	biolink:BiologicalProcess	cell cycle phase	One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.		hp.json		http://purl.obolibrary.org/obo/GO_0022403		gocheck_do_not_annotate
OBO:MAXO_0001249	biolink:NamedThing	vitamin C measurement	The determination of the amount of vitamin C present in the sample.		hp.json	vitamin C test|vitamin C assessment	http://purl.obolibrary.org/obo/MAXO_0001249		
HP:0008784	biolink:PhenotypicFeature	Wide capital femoral epiphyses	Abnormally wide morphology of the proximal epiphysis of the femur.	UMLS:C4024622	hp.json	Wide end part of innermost thighbone	http://purl.obolibrary.org/obo/HP_0008784		
OBO:MAXO_0001248	biolink:NamedThing	vitamin D measurement	The determination of the amount of vitamin D present in the sample.		hp.json	vitamin D test|vitamin D assessment	http://purl.obolibrary.org/obo/MAXO_0001248		
GO:0022406	biolink:BiologicalProcess	membrane docking	The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.		hp.json		http://purl.obolibrary.org/obo/GO_0022406		goslim_pir
OBO:MAXO_0001247	biolink:NamedThing	vitamin B12 measurement	The determination of the amount of vitamin B12 present in the sample.		hp.json	vitamin B12 test|vitamin B12 assessment	http://purl.obolibrary.org/obo/MAXO_0001247		
HP:0008786	biolink:PhenotypicFeature	Iliac crest serration	Irregularities of the iliac crest that produce the appearance of a lace border around it.	UMLS:C1857186	hp.json	Lacy appearance of iliac crest|Irregular lacy iliac crest	http://purl.obolibrary.org/obo/HP_0008786		
GO:0022408	biolink:BiologicalProcess	negative regulation of cell-cell adhesion	Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.		hp.json	down regulation of cell-cell adhesion|inhibition of cell-cell adhesion|down-regulation of cell-cell adhesion|downregulation of cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0022408		
CHEBI:59238	biolink:ChemicalSubstance	cyclic fatty acid	Any fatty acid containing anywhere in its structure a ring of atoms.	PMID:17113094|PMID:9300789	hp.json	zyklische Fettsaeuren|acides gras cycliques|cyclic fatty acids|acidos grasos ciclicos	http://purl.obolibrary.org/obo/CHEBI_59238		3_STAR
HP:0008780	biolink:PhenotypicFeature	Congenital bilateral hip dislocation		UMLS:C0158713|SNOMEDCT_US:10155006	hp.json		http://purl.obolibrary.org/obo/HP_0008780		
CHEBI:35284	biolink:ChemicalSubstance	ammonium betaine	Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom.		hp.json	ammonium betaines	http://purl.obolibrary.org/obo/CHEBI_35284		3_STAR
GO:0022407	biolink:BiologicalProcess	regulation of cell-cell adhesion	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.		hp.json		http://purl.obolibrary.org/obo/GO_0022407		
HP:0033719	biolink:PhenotypicFeature	EEG with parietal epileptiform discharges	Focal epileptiform EEG discharges recorded in the parietal region.		hp.json		http://purl.obolibrary.org/obo/HP_0033719		
HP:0008783	biolink:PhenotypicFeature	Wide proximal femoral metaphysis	Increased width of the proximal part of the shaft (metaphysis) of the femur.	UMLS:C4024623	hp.json	Wide metaphysis of innermost thighbone	http://purl.obolibrary.org/obo/HP_0008783		
GO:0022409	biolink:BiologicalProcess	positive regulation of cell-cell adhesion	Any process that activates or increases the rate or extent of cell adhesion to another cell.		hp.json	activation of cell-cell adhesion|upregulation of cell-cell adhesion|up regulation of cell-cell adhesion|stimulation of cell-cell adhesion|up-regulation of cell-cell adhesion	http://purl.obolibrary.org/obo/GO_0022409		
HP:0006121	biolink:PhenotypicFeature	Acral ulceration	A type of digital ulcer that manifests as an open sore on the surface of the skin at the tip of a finger or toe.	UMLS:C1860099	hp.json		http://purl.obolibrary.org/obo/HP_0006121		
GO:0071383	biolink:BiologicalProcess	cellular response to steroid hormone stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071383		
GO:0034390	biolink:BiologicalProcess	smooth muscle cell apoptotic process	Any apoptotic process in a smooth muscle cell. Smooth muscle consists of non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels.		hp.json	programmed cell death of smooth muscle cells by apoptosis|smooth muscle cell programmed cell death by apoptosis|SMC apoptosis|apoptosis of smooth muscle cells|smooth muscle cell apoptosis|programmed cell death, smooth muscle cells	http://purl.obolibrary.org/obo/GO_0034390		
GO:0034391	biolink:BiologicalProcess	regulation of smooth muscle cell apoptotic process	Any process that modulates the frequency, rate, or extent of smooth muscle cell apoptotic process.		hp.json	regulation of smooth muscle cell apoptosis|regulation of SMC apoptosis	http://purl.obolibrary.org/obo/GO_0034391		
GO:0034392	biolink:BiologicalProcess	negative regulation of smooth muscle cell apoptotic process	Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell apoptotic process.		hp.json	inhibition of smooth muscle cell apoptosis|down-regulation of smooth muscle cell apoptosis|negative regulation of SMC apoptosis|downregulation of smooth muscle cell apoptosis|negative regulation of smooth muscle cell apoptosis|down regulation of smooth muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0034392		
GO:0034393	biolink:BiologicalProcess	positive regulation of smooth muscle cell apoptotic process	Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.		hp.json	positive regulation of SMC apoptosis|positive regulation of smooth muscle cell apoptosis|upregulation of smooth muscle cell apoptosis|up regulation of smooth muscle cell apoptosis|stimulation of smooth muscle cell apoptosis|up-regulation of smooth muscle cell apoptosis|activation of smooth muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0034393		
PR:P56528	biolink:Protein	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (mouse)	An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 that is encoded in the genome of mouse.	UniProtKB:P56528	hp.json	2'-phospho-cyclic-ADP-ribose transferase (mouse)|ADP-ribosyl cyclase 1 (mouse)|CD38 (mouse)|cyclic ADP-ribose hydrolase 1 (mouse)|Cd38|cADPr hydrolase 1 (mouse)|ADPRC 1 (mouse)|mCD38|2'-phospho-ADP-ribosyl cyclase (mouse)|NIM-R5 antigen (mouse)|I-19 (mouse)|2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (mouse)	http://purl.obolibrary.org/obo/PR_P56528		
GO:0071377	biolink:BiologicalProcess	cellular response to glucagon stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071377		
GO:0071375	biolink:BiologicalProcess	cellular response to peptide hormone stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.		hp.json	cellular response to polypeptide hormone stimulus	http://purl.obolibrary.org/obo/GO_0071375		
HP:0008716	biolink:PhenotypicFeature	Urethrovaginal fistula	The presence of a fistula between the vagina and the urethra.	UMLS:C0269133|SNOMEDCT_US:50477003	hp.json	Urethrovaginal fistulae	http://purl.obolibrary.org/obo/HP_0008716		
HP:0008715	biolink:PhenotypicFeature	Testicular dysgenesis		UMLS:C0302885|SNOMEDCT_US:253847002	hp.json		http://purl.obolibrary.org/obo/HP_0008715		
HP:0008718	biolink:PhenotypicFeature	Unilateral renal dysplasia	A unilateral form of developmental dysplasia of the kidney.	SNOMEDCT_US:204951002|UMLS:C0431697	hp.json		http://purl.obolibrary.org/obo/HP_0008718		
HP:0008717	biolink:PhenotypicFeature	Unilateral renal atrophy	A unilateral form of atrophy of the kidney.	SNOMEDCT_US:424998002|UMLS:C1827184	hp.json	Kidney degeneration on one side|Unilateral kidney wasting	http://purl.obolibrary.org/obo/HP_0008717		
HP:0008711	biolink:PhenotypicFeature	Benign prostatic hyperplasia	The presence of non-malignant hyperplasia of the prostate.	UMLS:C1704272|MSH:D011470|UMLS:C0005001|SNOMEDCT_US:266569009	hp.json	Benign prostatic hypertrophy	http://purl.obolibrary.org/obo/HP_0008711		
HP:0008714	biolink:PhenotypicFeature	Ureterovesical stenosis		UMLS:C4024633	hp.json		http://purl.obolibrary.org/obo/HP_0008714		
GO:0071396	biolink:BiologicalProcess	cellular response to lipid	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071396		
HP:0008726	biolink:PhenotypicFeature	Hypoplasia of the vagina	Developmental hypoplasia of the vagina.	SNOMEDCT_US:253836009|UMLS:C1442988|UMLS:C0345309	hp.json	Hypoplastic vagina|Underdeveloped vagina|Rudimentary vagina	http://purl.obolibrary.org/obo/HP_0008726		
HP:0008729	biolink:PhenotypicFeature	Absence of labia majora		UMLS:C1849575	hp.json	Absent vaginal lips	http://purl.obolibrary.org/obo/HP_0008729		
HP:0008723	biolink:PhenotypicFeature	Gonadal dysgenesis with female appearance, male	Unusual gonadal development in a person with a 46,XY male karyotype, leading to a more female sex differentiation.	UMLS:C4020788|UMLS:C4024632	hp.json	Xy female gonadal dysgenesis	http://purl.obolibrary.org/obo/HP_0008723		
HP:0008722	biolink:PhenotypicFeature	Urethral diverticulum	The presence of a diverticulum (sac or pouch) in the wall of the urethra.	SNOMEDCT_US:90531003|UMLS:C0152443	hp.json		http://purl.obolibrary.org/obo/HP_0008722		
HP:0008724	biolink:PhenotypicFeature	Hypoplasia of the ovary	Developmental hypoplasia of the ovary.	UMLS:C0685840|SNOMEDCT_US:93279005|UMLS:C1835452	hp.json	Hypoplastic ovary|Underdeveloped ovary	http://purl.obolibrary.org/obo/HP_0008724		
HP:0008720	biolink:PhenotypicFeature	Primary testicular failure		UMLS:C1384582|SNOMEDCT_US:48723006|SNOMEDCT_US:370997001	hp.json		http://purl.obolibrary.org/obo/HP_0008720		
GO:0034352	biolink:BiologicalProcess	positive regulation of glial cell apoptotic process	Any process that activates or increases the frequency, rate, or extent of glial cell apoptotic process.		hp.json	positive regulation of glial cell apoptosis|upregulation of glial cell apoptosis|up regulation of glial cell apoptosis|stimulation of glial cell apoptosis|up-regulation of glial cell apoptosis|activation of glial cell apoptosis	http://purl.obolibrary.org/obo/GO_0034352		
GO:0034358	biolink:CellularComponent	plasma lipoprotein particle	A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.		hp.json		http://purl.obolibrary.org/obo/GO_0034358		
GO:0034350	biolink:BiologicalProcess	regulation of glial cell apoptotic process	Any process that modulates the frequency, rate, or extent of glial cell apoptotic process.		hp.json	regulation of glial cell apoptosis	http://purl.obolibrary.org/obo/GO_0034350		
GO:0034351	biolink:BiologicalProcess	negative regulation of glial cell apoptotic process	Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.		hp.json	down regulation of glial cell apoptosis|inhibition of glial cell apoptosis|down-regulation of glial cell apoptosis|downregulation of glial cell apoptosis|negative regulation of glial cell apoptosis	http://purl.obolibrary.org/obo/GO_0034351		
GO:0034349	biolink:BiologicalProcess	glial cell apoptotic process	Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.		hp.json	glial cell apoptosis|glial cell programmed cell death by apoptosis|apoptosis of glia|programmed cell death of glia by apoptosis|apoptosis of glial cells|programmed cell death of glial cells by apoptosis|glia apoptosis|programmed cell death, glia|programmed cell death, glial cells|glia programmed cell death by apoptosis	http://purl.obolibrary.org/obo/GO_0034349		
HP:0008708	biolink:PhenotypicFeature	Partial development of the penile shaft		UMLS:C1837379	hp.json		http://purl.obolibrary.org/obo/HP_0008708		
HP:0008705	biolink:PhenotypicFeature	Ureteral triplication		UMLS:C4024635	hp.json		http://purl.obolibrary.org/obo/HP_0008705		
HP:0008707	biolink:PhenotypicFeature	Absent scrotum	Congenital absence of the scrotum.	SNOMEDCT_US:249233008|UMLS:C0426320	hp.json	Absent scrotum	http://purl.obolibrary.org/obo/HP_0008707		
HP:0008706	biolink:PhenotypicFeature	Distal urethral duplication		UMLS:C4024634	hp.json		http://purl.obolibrary.org/obo/HP_0008706		
HP:0008703	biolink:PhenotypicFeature	Gonadal calcification	Deposition of calcium salts in gonadal tissue.	UMLS:C4024636	hp.json		http://purl.obolibrary.org/obo/HP_0008703		
HP:0008702	biolink:PhenotypicFeature	Absent internal genitalia		UMLS:C4024637	hp.json		http://purl.obolibrary.org/obo/HP_0008702		
GO:0046326	biolink:BiologicalProcess	positive regulation of glucose import	Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.		hp.json	up-regulation of glucose import|activation of glucose import|positive regulation of glucose uptake|upregulation of glucose import|up regulation of glucose import|stimulation of glucose import	http://purl.obolibrary.org/obo/GO_0046326		
GO:0046325	biolink:BiologicalProcess	negative regulation of glucose import	Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.		hp.json	negative regulation of glucose uptake|downregulation of glucose import|down regulation of glucose import|inhibition of glucose import|down-regulation of glucose import	http://purl.obolibrary.org/obo/GO_0046325		
CHEBI:37838	biolink:ChemicalSubstance	carboacyl group	A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid.		hp.json	carboxylic acyl groups|carboxylic acyl group|carboacyl groups	http://purl.obolibrary.org/obo/CHEBI_37838		3_STAR
GO:0046324	biolink:BiologicalProcess	regulation of glucose import	Any process that modulates the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.		hp.json	regulation of glucose uptake	http://purl.obolibrary.org/obo/GO_0046324		
UBERON:0014463	biolink:AnatomicalEntity	cardiac ganglion	Any of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery.	EMAPA:36644|FMA:77582	hp.json	cardiac ganglia|Wrisberg ganglion|cardiac ganglion of Wrisberg|ganglia cardiaca|ganglion of Wrisberg|cardiac ganglia set	http://purl.obolibrary.org/obo/UBERON_0014463		
GO:0046323	biolink:BiologicalProcess	glucose import	The directed movement of the hexose monosaccharide glucose into a cell or organelle.	Wikipedia:Glucose_uptake	hp.json	glucose uptake	http://purl.obolibrary.org/obo/GO_0046323		
UBERON:0014464	biolink:AnatomicalEntity	renal fat pad	Encapsulated adipose tissue associated with the kidney.		hp.json	perirenal fat pad	http://purl.obolibrary.org/obo/UBERON_0014464		pheno_slim|human_reference_atlas
UBERON:0014466	biolink:AnatomicalEntity	subarachnoid fissure		FMA:75136	hp.json		http://purl.obolibrary.org/obo/UBERON_0014466		
UBERON:0002481	biolink:AnatomicalEntity	bone tissue	Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts.	CALOHA:TS-2011|MESH:D001842|ZFA:0005621|UMLS:C0391978|galen:BoneTissue|FMA:224804|MA:0002780|NCIT:C13076|VSAO:0000047|XAO:0004040|EMAPA:35179|Wikipedia:Bone_tissue	hp.json	bone|calcium tissue|portion of bone tissue|osteogenic tissue|mineralized bone tissue|osseous tissue	http://purl.obolibrary.org/obo/UBERON_0002481		pheno_slim|uberon_slim
CL:0002144	biolink:Cell	capillary endothelial cell	An endothelial cell found in capillaries.	BTO:0004956|FMA:67756|CALOHA:TS-0112	hp.json		http://purl.obolibrary.org/obo/CL_0002144		
UBERON:0002483	biolink:AnatomicalEntity	trabecular bone tissue	Bone tissue that has a lattice-like or spongy structure; it is highly vascular and contains intercommunicating spaces filled with bone marrow.	BTO:0001700|MA:0002782|FMA:24019|EMAPA:35873|CALOHA:TS-0110	hp.json	substantia spongiosa ossium|cancellous bone tissue|trabecular substance|spongy bone|substantia trabecularis ossium|substantia spongiosa|cancellated bone|substantia trabecularis|cancellous bone|spongy bone tissue|trabecular bone	http://purl.obolibrary.org/obo/UBERON_0002483		pheno_slim|uberon_slim
CL:0002145	biolink:Cell	ciliated columnar cell of tracheobronchial tree	A ciliated columnar cell found in the trachea and bronchus. Vary from low to tall columnar; possesses up to 300 cilia at its surface, interspersed with long irregular microvilli with the cilia varying in length from about 6um in the trachea to about 4um in the terminal bronchioles; driving force of the ciliary current in the bronchial tree.	FMA:70542	hp.json		http://purl.obolibrary.org/obo/CL_0002145		
UBERON:0002482	biolink:AnatomicalEntity	lamellar bone	Bone tissue that has a regular parallel alignment of collagen into sheets (lamellae) and is mechanically strong.	EMAPA:37625|FMA:224806|MA:0002781|galen:LamellarBone	hp.json		http://purl.obolibrary.org/obo/UBERON_0002482		
CL:0002149	biolink:Cell	epithelial cell of uterus	An epithelial cell of the uterus.	FMA:256161	hp.json		http://purl.obolibrary.org/obo/CL_0002149		
UBERON:0002489	biolink:AnatomicalEntity	coronal suture	The dense, fibrous connective tissue joint between the tetrapod parietal bones and the frontal bone.	EMAPA:19225|MA:0002795|FMA:52928|OpenCyc:Mx4rv2eGHZwpEbGdrcN5Y29ycA	hp.json	coronal suture of skull|frontoparietal suture|fronto-parietal suture|sutura coronalis	http://purl.obolibrary.org/obo/UBERON_0002489		pheno_slim|uberon_slim
UBERON:0002488	biolink:AnatomicalEntity	helix of outer ear	The helix is the prominent rim of the pinna.	UMLS:C0229304|MA:0002793|OpenCyc:Mx4rwRDEk5wpEbGdrcN5Y29ycA|FMA:60992|NCIT:C32724	hp.json	helix (auricula)|helix of pinna|helical part of pinna|helix of ear|helix|helix of auricle of ear	http://purl.obolibrary.org/obo/UBERON_0002488		pheno_slim|uberon_slim
UBERON:0002485	biolink:AnatomicalEntity	prostate duct	The minute canals that pass the prostatic secretions to the urethra.	MA:0002785|NCIT:C13102|FMA:19580|EMAPA:36568|UMLS:C0227965	hp.json	duct of prostate|prostate duct|prostate gland duct|prostatic duct|duct of prostate gland	http://purl.obolibrary.org/obo/UBERON_0002485		pheno_slim
UBERON:0002484	biolink:AnatomicalEntity	bone marrow cavity	The medullary cavities of the bones where bone marrow is stored.	FMA:83698|MA:0002783|FMA:75147	hp.json	medullary cavity|cavity of cancellous bone|marrow cavity	http://purl.obolibrary.org/obo/UBERON_0002484		pheno_slim
UBERON:0002486	biolink:AnatomicalEntity	glottis	The vocal apparatus of the larynx, which includes the vocal cords and the opening between them.	BTO:0001627|GAID:343|AAO:0010610|MESH:D005931|FMA:55414|UMLS:C0017681|MA:0002788|NCIT:C12724	hp.json		http://purl.obolibrary.org/obo/UBERON_0002486		pheno_slim|uberon_slim
UBERON:0014451	biolink:AnatomicalEntity	tongue taste bud	A taste bud that is located on the tongue, situated on a gustatory papilla.		hp.json	gustatory papillae taste bud|gustatory papilla taste bud	http://purl.obolibrary.org/obo/UBERON_0014451		pheno_slim
CHEBI:37848	biolink:ChemicalSubstance	plant hormone	A plant growth regulator that modulates the formation of stems, leaves and flowers, as well as the development and ripening of fruit. The term includes endogenous and non-endogenous compounds (e.g. active compounds produced by bacteria on the leaf surface) as well as semi-synthetic and fully synthetic compounds.	Wikipedia:Phytohormone	hp.json	plant hormones|plant growth factor|plant growth hormones|plant growth hormone|plant growth factors|phytohormones|phytohormone	http://purl.obolibrary.org/obo/CHEBI_37848		3_STAR
UBERON:0014452	biolink:AnatomicalEntity	gustatory epithelium of tongue	A gustatory epithelium that is part of a tongue.	BIRNLEX:4099|UMLS:C1179150	hp.json	lingual gustatory epithelium|lingual gustatory epithelium	http://purl.obolibrary.org/obo/UBERON_0014452		
UBERON:0014453	biolink:AnatomicalEntity	gustatory epithelium of palate	A gustatory epithelium that is part of a roof of mouth.		hp.json	palatal gustatory epithelium	http://purl.obolibrary.org/obo/UBERON_0014453		
UBERON:0014454	biolink:AnatomicalEntity	visceral abdominal adipose tissue	Subcutaneous adipose tissue that is located in the peritoneal cavity.	BTO:0004041|CALOHA:TS-2405	hp.json	intra-abdominal fat|abdominal fat|organ fat|intra-abdominal adipose tissue|visceral fat|visceral adipose tissue	http://purl.obolibrary.org/obo/UBERON_0014454		
UBERON:0014455	biolink:AnatomicalEntity	subcutaneous abdominal adipose tissue	Subcutaneous adipose tissue that is located in the abdominal region.	CALOHA:TS-2406	hp.json	subcutaneous abdominal fat|subcutaneous fat of abdominal region|abdominal subcutaneous adipose tissue	http://purl.obolibrary.org/obo/UBERON_0014455		
UBERON:0002470	biolink:AnatomicalEntity	autopod region	Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot.	EFO:0000877|MIAA:0000091|FMA:83015|UMLS:C0687080|EMAPA:32722|NCIT:C77660|BTO:0004359|MA:0002714|MAT:0000091	hp.json	autopodial limb segment|autopodium|autopod|autopodium region|autopodial element|distal segment of limb|paw/hand/foot/hoof|distal free limb segment|manus/pes|distal segment of free limb|autopodial segment|paw|pod	http://purl.obolibrary.org/obo/UBERON_0002470		pheno_slim|efo_slim|uberon_slim
UBERON:0002472	biolink:AnatomicalEntity	stylopod	The proximal free limb segment. Includes as parts the stylopod skeleton.	EFO:0000879|MIAA:0000093|FMA:83014|MA:0002717|MAT:0000093	hp.json	proximal free limb segment|proximal part of limb|stylopodium|proximal segment of free limb|stylopodial limb segment|propodium	http://purl.obolibrary.org/obo/UBERON_0002472		efo_slim|uberon_slim
GO:0061951	biolink:BiologicalProcess	establishment of protein localization to plasma membrane	The directed movement of a protein to a specific location in a plasma membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0061951		
UBERON:0002471	biolink:AnatomicalEntity	zeugopod	The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus).	EFO:0000878|MIAA:0000092|FMA:83016|MA:0002716|MAT:0000092	hp.json	middle part of limb|zygopod|zeugopodium|zeugopodial limb segment|zeugopod limb segment|middle segment of free limb|middle free limb segment|zygopodium|epipodium|middle limb segment	http://purl.obolibrary.org/obo/UBERON_0002471		pheno_slim|efo_slim|uberon_slim
CL:0002159	biolink:Cell	general ecto-epithelial cell	Epithelial cells derived from general body ectoderm and ectoderm placodes.	FMA:70556	hp.json		http://purl.obolibrary.org/obo/CL_0002159		
CHEBI:13850	biolink:ChemicalSubstance	apoprotein	An apoprotein is a protein devoid of its characteristic prosthetic group or metal.	KEGG:C16240	hp.json	apoproteins|apoprotein	http://purl.obolibrary.org/obo/CHEBI_13850		3_STAR
UBERON:0002478	biolink:AnatomicalEntity	orbitosphenoid	The bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young.	FMA:52869|VHOG:0001153|MA:0002773|ZFA:0000253|AAO:0000345|TAO:0000253|EMAPA:18719	hp.json	alae parvae|lesser wing of sphenoid bone|ala minor (os sphenoidale)|ala minor ossis sphenoidalis|orbitosphenoids|orbitosphenoid bone|lesser wing of sphenoidal bone|lesser wing of sphenoid|ingrassia's process	http://purl.obolibrary.org/obo/UBERON_0002478		vertebrate_core|pheno_slim
UBERON:0002474	biolink:AnatomicalEntity	cerebellar peduncular complex	A composite structure of the brain stem, which is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM)[NIF, based on NN].	FMA:77791|BAMS:cbp|MBA:752|BIRNLEX:970|UMLS:C0228514|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=224	hp.json	set of cerebellar peduncles|cerebellar peduncles and decussations|basal ganglia (anatomic)|cerebellum peduncles|ganglia basales|corpus striatum (Savel'ev)|cerebellar peduncles set|pedunculi cerebellares|cerebellar peduncles	http://purl.obolibrary.org/obo/UBERON_0002474		uberon_slim
UBERON:0002473	biolink:AnatomicalEntity	intercerebral commissure	A commissure that connects the two cerebral hemispheres. Examples: anterior commissure, corpus callosum.	MA:0002721|FMA:67930|EMAPA:35435	hp.json	inter-hemispheric commissure|interhemispheric commissure|commissure of cerebrum	http://purl.obolibrary.org/obo/UBERON_0002473		
CL:0002153	biolink:Cell	corneocyte	The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus.	BTO:0001943|FMA:68650	hp.json		http://purl.obolibrary.org/obo/CL_0002153		
CHEBI:25830	biolink:ChemicalSubstance	p-quinones	A quinone in which the two oxo groups of the quinone are located para to each other on the 6-membered quinonoid ring.		hp.json	para-quinones|p-quinone	http://purl.obolibrary.org/obo/CHEBI_25830		3_STAR
UBERON:0002459	biolink:AnatomicalEntity	inferior palpebral vein	A blood vessel that drains from from an lower eyelid.	EMAPA:37156|FMA:50913|UMLS:C1760539|NCIT:C53049|MA:0002147	hp.json	venae palpebrales inferiores|vein of inferior eyelid|inferior palpebral veins set|lower palpebral vein|inferior palpebral veins	http://purl.obolibrary.org/obo/UBERON_0002459		human_reference_atlas
UBERON:0014445	biolink:AnatomicalEntity	acetabular fossa	The acetabular fossa is the roughened depression in the centre of the acetabulum, surrounded by the lunate acetabular surface and the acetabular notch. The acetabular fossa provides an insertion point for the teres ligaments that secure the femoral head.	FMA:17269	hp.json	fossa acetabularis (acetabuli)|fossa acetabularis|fossa acetabuli	http://purl.obolibrary.org/obo/UBERON_0014445		pheno_slim
UBERON:0014446	biolink:AnatomicalEntity	acetabular notch	The acetabulum presents below a deep notch, the acetabular notch, which is continuous with a circular non-articular depression, the acetabular fossa, at the bottom of the cavity: this depression is perforated by numerous apertures, and lodges a mass of fat. The notch is converted into a foramen by the transverse ligament; through the foramen nutrient vessels and nerves enter the joint; the margins of the notch serve for the attachment of the ligament of the head of the femur.	FMA:16944	hp.json		http://purl.obolibrary.org/obo/UBERON_0014446		
UBERON:0014444	biolink:AnatomicalEntity	pubic ramus			hp.json	ramus of pubis	http://purl.obolibrary.org/obo/UBERON_0014444		pheno_slim
UBERON:0002461	biolink:AnatomicalEntity	anterior abdominal wall muscle	Any skeletal muscle organ that is part of a anterior abdominal wall. Examples: the obliques, pyramidalis and transversus abdominus.	MA:0002268|EHDAA2:0000125|NCIT:C52890|FMA:20278|EMAPA:17745|UMLS:C1744565|EMAPA:17744	hp.json	ventral abdominal wall muscle|muscle of anterior abdominal wall	http://purl.obolibrary.org/obo/UBERON_0002461		
UBERON:0002460	biolink:AnatomicalEntity	vesical vein	A tributary of the iliac vein that drains the urinary bladder.	EMAPA:37205|MA:0002263	hp.json	vesical veins|vesical veins set|venae vesicales	http://purl.obolibrary.org/obo/UBERON_0002460		human_reference_atlas|uberon_slim
UBERON:0014438	biolink:AnatomicalEntity	superior pubic ramus	The superior pubic ramus is a part of the pubic bone which forms a portion of the obturator foramen. It extends from the body to the median plane where it articulates with its fellow of the opposite side. It is conveniently described in two portions, viz. , a medial flattened part and a narrow lateral prismoid portion.	FMA:16988	hp.json	superior rami of the pubes|superior ramus of pubis|superior ramus of the pubis	http://purl.obolibrary.org/obo/UBERON_0014438		
UBERON:0014439	biolink:AnatomicalEntity	inferior pubic ramus	The inferior pubic ramus is thin and flattened. It passes lateralward and downward from the medial end of the superior ramus; it becomes narrower as it descends and joins with the inferior ramus of the ischium below the obturator foramen.	FMA:16989	hp.json	inferior ramus of pubis|inferior rami of the pubes|inferior ramus of the pubis	http://purl.obolibrary.org/obo/UBERON_0014439		pheno_slim
UBERON:0002466	biolink:AnatomicalEntity	intestine secretion	Clear to pale yellow watery secretions from the glands lining the small intestine walls. Secretion is stimulated by the mechanical pressure of partly digested food in the intestine.	UMLS:C0021849|MA:0002515|GAID:1162|NCIT:C32875|MESH:D007419|FMA:62974|BTO:0000644|Wikipedia:Succus_entericus	hp.json	succus entericus|succus entericus|intestinal juice|intestinal secretion	http://purl.obolibrary.org/obo/UBERON_0002466		uberon_slim|pheno_slim
UBERON:0002469	biolink:AnatomicalEntity	esophagus mucosa	A mucosa that is part of a esophagus [Automatically generated definition].	SCTID:362127004|NCIT:C32538|EMAPA:26981|BTO:0002859|MESH:D000071041|FMA:62996|MA:0002680|UMLS:C0227176	hp.json	oesophagus mucosa|mucosa of esophagus|mucous membrane of esophagus|tunica mucosa esophagi|esophageal mucous membrane|esophageal mucosa|tunica mucosa oesophagi|tunica mucosa oesophagi|mucous membrane of oesophagus|oesophagus mucous membrane|lamina muscularis mucosae oesophageae|tunica mucosa oesophageae|esophagus mucous membrane|esophagus mucosa|muscularis mucosae of oesophagus|mucosa of oesophagus|oesophageal mucosa	http://purl.obolibrary.org/obo/UBERON_0002469		
UBERON:0002463	biolink:AnatomicalEntity	muscle of posterior compartment of hindlimb stylopod	Any of the posterior thigh muscles. [WP,modified].	EHDAA:8295|MA:0002312|UMLS:C0584895|EMAPA:19145|FMA:22427|VHOG:0000844|NCIT:C53042|FMA:81022|EHDAA2:0000727|BTO:0003179|OpenCyc:Mx4rvVjdtJwpEbGdrcN5Y29ycA	hp.json	hamstring muscle|set of hamstring muscles|posterior femoral muscles|posterior femoral muscle|muscle of posterior compartment of thigh|hamstring|posterior fascial compartment of thigh|muscularis compartimentum femoris posterius	http://purl.obolibrary.org/obo/UBERON_0002463		uberon_slim
UBERON:0002465	biolink:AnatomicalEntity	lymphoid system	The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system[WP].	GAID:931|MIAA:0000197|NCIT:C12746|MA:0002435|UMLS:C0024235|ZFA:0000385|XAO:0003199|Wikipedia:Lymphoid_system|TAO:0000385|EMAPA:37664|OpenCyc:Mx4rwQAKT5wpEbGdrcN5Y29ycA|EHDAA:8677|VHOG:0000842|MAT:0000197|EHDAA2:0001043|SCTID:362589007|FMA:74594	hp.json	lymphatic circulatory system|lymphatic drainage system|systema lymphoideum|lymphatic drainage system|systema lymphoideum|lymphatic circulatory system|lymphatic system	http://purl.obolibrary.org/obo/UBERON_0002465		uberon_slim|vertebrate_core
UBERON:0002464	biolink:AnatomicalEntity	nerve trunk		BTO:0000927|FMA:14383|EHDAA:4675|FMA:5913|MA:0002408|MA:0000229|EMAPA:16986	hp.json	trunk of peripheral nerve|trunk of nerve|peripheral nerve trunk	http://purl.obolibrary.org/obo/UBERON_0002464		
GO:1900426	biolink:BiologicalProcess	positive regulation of defense response to bacterium	Any process that activates or increases the frequency, rate or extent of defense response to bacterium.		hp.json	up-regulation of defence response to bacterium|upregulation of defense response to bacteria|upregulation of defence response to bacteria|up-regulation of defense response to bacterium|activation of resistance response to pathogenic bacterium|positive regulation of defense response to bacterium, incompatible interaction|up regulation of defence response to bacterium|up regulation of defense response to bacterium|positive regulation of defence response to bacteria|activation of defense response to bacterium|positive regulation of defense response to bacteria|positive regulation of defence response to bacterium|activation of antibacterial peptide activity|upregulation of antibacterial peptide activity|up regulation of defense response to bacteria|up regulation of defence response to bacteria|upregulation of defense response to bacterium|upregulation of defence response to bacterium|up-regulation of defense response to bacteria|up-regulation of defence response to bacteria|positive regulation of antibacterial peptide activity|activation of defence response to bacterium|up regulation of antibacterial peptide activity|activation of resistance response to pathogenic bacteria|up-regulation of antibacterial peptide activity|activation of defense response to bacteria|activation of defence response to bacteria	http://purl.obolibrary.org/obo/GO_1900426		
GO:1900425	biolink:BiologicalProcess	negative regulation of defense response to bacterium	Any process that stops, prevents or reduces the frequency, rate or extent of defense response to bacterium.		hp.json	inhibition of defence response to pathogenic bacterium, incompatible interaction|inhibition of defense response to bacterium, incompatible interaction|inhibition of response to pathogenic bacterium (incompatible interaction)|inhibition of resistance response to pathogenic bacteria|inhibition of response to pathogenic bacteria (incompatible interaction)|inhibition of defense response to bacteria|down regulation of antibacterial peptide activity|inhibition of defence response to bacteria|inhibition of defence response to bacterium|negative regulation of defense response to bacterium, incompatible interaction|down-regulation of antibacterial peptide activity|negative regulation of antibacterial peptide activity|downregulation of defence response to bacteria|down-regulation of defence response to bacterium|negative regulation of defence response to bacterium|downregulation of defense response to bacteria|down-regulation of defense response to bacterium|inhibition of antibacterial peptide activity|down regulation of defense response to bacterium|down regulation of defence response to bacterium|down regulation of defence response to bacteria|down regulation of defense response to bacteria|inhibition of resistance response to pathogenic bacterium|downregulation of defence response to bacterium|downregulation of antibacterial peptide activity|negative regulation of defense response to bacteria|negative regulation of defence response to bacteria|down-regulation of defense response to bacteria|inhibition of defense response to bacterium|down-regulation of defence response to bacteria|downregulation of defense response to bacterium|inhibition of defence response to pathogenic bacteria, incompatible interaction	http://purl.obolibrary.org/obo/GO_1900425		
GO:1900424	biolink:BiologicalProcess	regulation of defense response to bacterium	Any process that modulates the frequency, rate or extent of defense response to bacterium.		hp.json	regulation of antibacterial peptide activity|regulation of resistance response to pathogenic bacterium|regulation of defence response to pathogenic bacterium, incompatible interaction|regulation of resistance response to pathogenic bacteria|regulation of defence response to pathogenic bacteria, incompatible interaction|regulation of defence response to bacterium, incompatible interaction|regulation of defense response to bacterium, incompatible interaction|regulation of defense response to bacteria|regulation of defence response to bacteria|regulation of defence response to bacterium	http://purl.obolibrary.org/obo/GO_1900424		
CHEBI:37826	biolink:ChemicalSubstance	sulfuric acid derivative			hp.json	sulfuric acid derivatives|sulfuric acid derivative	http://purl.obolibrary.org/obo/CHEBI_37826		3_STAR
UBERON:0014437	biolink:AnatomicalEntity	iliac crest	Is part of the pelvis on the edge of the wing of the ilium. Round in shape, dorsal to the pubis and ischium. Acts as structrure that muscles can attach too.	MA:0003053|NCIT:C103818|EMAPA:37602|FMA:16914	hp.json		http://purl.obolibrary.org/obo/UBERON_0014437		pheno_slim
UBERON:0014430	biolink:AnatomicalEntity	sciatic notch	Either of two notches on the dorsal border of the hip bone on each side that when closed off by ligaments form the corresponding sciatic foramina.		hp.json		http://purl.obolibrary.org/obo/UBERON_0014430		
PR:000023661	biolink:Protein	orotidine 5'-phosphate decarboxylase	A protein that is a translation product of the Escherichia coli K-12 pyrF gene or a 1:1 ortholog thereof.		hp.json	pyrF|OMP decarboxylase|OMPdecase|OMPDCase	http://purl.obolibrary.org/obo/PR_000023661		
GO:0061971	biolink:BiologicalProcess	replacement bone morphogenesis	The process in which bones are generated and organized as a result of the conversion of another structural tissue into bone.		hp.json		http://purl.obolibrary.org/obo/GO_0061971		
CL:0002132	biolink:Cell	stromal cell of ovary	A stomal cell of the ovary	FMA:72299	hp.json	ovarian stromal cell	http://purl.obolibrary.org/obo/CL_0002132		
GO:0061973	biolink:BiologicalProcess	membrane bone morphogenesis	The process in which bone which forms deep in the organism are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0061973		
GO:0061972	biolink:BiologicalProcess	dermal bone morphogenesis	The process in which bone which forms superficially in the organism are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0061972		
CL:0002139	biolink:Cell	endothelial cell of vascular tree	An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.	BTO:0001854|FMA:67755|CALOHA:TS-1106	hp.json	vascular endothelial cell|cubodial endothelial cell of vascular tree	http://purl.obolibrary.org/obo/CL_0002139		
CL:0002138	biolink:Cell	endothelial cell of lymphatic vessel	A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions.	BTO:0004167|FMA:68458	hp.json	LEC|lymphatic endothelial cell	http://purl.obolibrary.org/obo/CL_0002138		
UBERON:0002456	biolink:AnatomicalEntity	internal thoracic artery	An artery that supplies the anterior chest wall and the breasts. It is a paired artery, with one running along each side of the sternum, to continue after its bifurcation as the superior epigastric and musculophrenic arteries. [WP,unvetted].	OpenCyc:Mx4rMe0MIao8EduQrwACs5b6Bw|EHDAA:8585|UMLS:C0226276|FMA:3960|NCIT:C52941|MA:0001984|MA:0001982|EHDAA2:0000880|EMAPA:18617	hp.json	arteria thoracica interna|arteria mammaria interna|internal thoracic mammary artery|internal mammary artery|mammary artery	http://purl.obolibrary.org/obo/UBERON_0002456		uberon_slim|human_reference_atlas
UBERON:0002458	biolink:AnatomicalEntity	spinal artery	Arteries that supply the spinal cord.	EHDAA2:0001890|SCTID:244228006|ZFA:0000682|NCIT:C33587|UMLS:C0447043|EMAPA:18241|TAO:0000682|EHDAA:4355|Wikipedia:Spinal_artery|MA:0002043	hp.json	spinal arteries	http://purl.obolibrary.org/obo/UBERON_0002458		uberon_slim|vertebrate_core
UBERON:0002457	biolink:AnatomicalEntity	intersomitic artery	The small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries.	EHDAA:4340|TAO:0001061|MA:0001985|EHDAA2:0000882|XAO:0004165|VHOG:0000225|EMAPA:17616|ZFA:0001061	hp.json	intersegmental arteries|intersegmental artery	http://purl.obolibrary.org/obo/UBERON_0002457		vertebrate_core|pheno_slim
UBERON:0002451	biolink:AnatomicalEntity	endometrial gland	The mucous secreting gland associated with the mucuous membrane lining the uterus.	Wikipedia:Uterine_glands|UMLS:C1183035|NCIT:C33842|BTO:0004518|EMAPA:29919|SCTID:361377009|MA:0001726|BTO:0003433	hp.json	glandulae uterinae|glandulae uterinae|endometrial mucuous gland|glandulae uterinae|endometrial gland|endometrium gland|uterine gland	http://purl.obolibrary.org/obo/UBERON_0002451		uberon_slim|organ_slim|pheno_slim|human_reference_atlas
OBO:chebi#has_functional_parent	biolink:NamedThing	has functional parent			hp.json		http://purl.obolibrary.org/obo/chebi#has_functional_parent		
UBERON:0002453	biolink:AnatomicalEntity	ethmoid sinus	The evaginations of the mucous membrane of the nasal cavity into the ethmoidal bony labyrinth, forming multiple small paranasal sinuses.	UMLS:C0015028|GAID:356|MA:0001792|FMA:84115|NCIT:C12276|MESH:D005005	hp.json	ethmoidal sinus|ethmoidal air cell|ethmoidal bone sinus|cellulae ethmoidales	http://purl.obolibrary.org/obo/UBERON_0002453		uberon_slim|pheno_slim
HP:0031060	biolink:PhenotypicFeature	Impaired ability to dress oneself	This applies to an individual who needs help with dressing or needs to be completely dressed.		hp.json		http://purl.obolibrary.org/obo/HP_0031060		
HP:0031061	biolink:PhenotypicFeature	Impaired toileting ability	This term applies to an individual who requires help transferring to the toilet, cleaning self or who uses bedpan or commode.		hp.json		http://purl.obolibrary.org/obo/HP_0031061		
HP:0031062	biolink:PhenotypicFeature	Impaired transferring ability	Applies to an individual who needs help in moving from bed to chair or requires a complete transfer.		hp.json		http://purl.obolibrary.org/obo/HP_0031062		
CHEBI:25810	biolink:ChemicalSubstance	oxopurine			hp.json	oxopurines	http://purl.obolibrary.org/obo/CHEBI_25810		3_STAR
HP:0031067	biolink:PhenotypicFeature	Empty ovarian follicle	A failure to collect oocytes after an apparently normal controlled ovarian hyperstimulation cycle for in vitro fertilization.		hp.json	Empty follicle syndrome	http://purl.obolibrary.org/obo/HP_0031067		
HP:0031068	biolink:PhenotypicFeature	obsolete Increased femoral torsion			hp.json		http://purl.obolibrary.org/obo/HP_0031068		
HP:0031069	biolink:PhenotypicFeature	Abnormal femoral torsion	Femoral torsion, also known as femoral rotation or femoral version, refers to the twist between the proximal and distal parts of the femur on the transverse plane. Femoral anteversion averages between 30-40 degress at birth, and between 8-14 degrees in adults. This term applies if the amount of femoral torsion deviates from this range.		hp.json		http://purl.obolibrary.org/obo/HP_0031069		
HP:0031063	biolink:PhenotypicFeature	Impaired feeding ability	Applies to an individual who needs partial or total help with feeding or requires parenteral feeding.		hp.json		http://purl.obolibrary.org/obo/HP_0031063		
HP:0031064	biolink:PhenotypicFeature	Impaired continence	Partial or total incontinence of bowel or bladder.		hp.json		http://purl.obolibrary.org/obo/HP_0031064		
HP:0031065	biolink:PhenotypicFeature	Abnormal ovarian morphology			hp.json		http://purl.obolibrary.org/obo/HP_0031065		
HP:0031066	biolink:PhenotypicFeature	Abnormal ovarian physiology	Any anomaly of ovarian function.		hp.json		http://purl.obolibrary.org/obo/HP_0031066		
GO:0046364	biolink:BiologicalProcess	monosaccharide biosynthetic process	The chemical reactions and pathways resulting in the formation of monosaccharides, polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms.		hp.json	monosaccharide formation|monosaccharide anabolism|monosaccharide biosynthesis|monosaccharide synthesis	http://purl.obolibrary.org/obo/GO_0046364		
CHEBI:84186	biolink:ChemicalSubstance	L-proline derivative	A proteinogenic amino acid derivative resulting from reaction of L-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of L-proline  by a heteroatom.		hp.json	L-proline derivatives	http://purl.obolibrary.org/obo/CHEBI_84186		3_STAR
CHEBI:84185	biolink:ChemicalSubstance	D-proline derivative	A non-proteinogenic amino acid derivative resulting from reaction of D-proline at the amino group or the carboxy group, or from the replacement of any hydrogen of D-proline by a heteroatom.		hp.json	D-proline derivatives	http://purl.obolibrary.org/obo/CHEBI_84185		3_STAR
GO:0071322	biolink:BiologicalProcess	cellular response to carbohydrate stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071322		
HP:0031070	biolink:PhenotypicFeature	obsolete Femoral retroversion			hp.json		http://purl.obolibrary.org/obo/HP_0031070		
HP:0031071	biolink:PhenotypicFeature	Abnormal endocrine morphology	Any anomaly of the structure of an organ ofthe endocrine system.		hp.json		http://purl.obolibrary.org/obo/HP_0031071		
HP:0031072	biolink:PhenotypicFeature	Abnormal endocrine physiology	Any anomaly of the function of the endocrine system.		hp.json		http://purl.obolibrary.org/obo/HP_0031072		
HP:0031073	biolink:PhenotypicFeature	Abnormal response to endocrine stimulation test	An anomalous response to a test that is designed to probe the function of the endocrine system.		hp.json		http://purl.obolibrary.org/obo/HP_0031073		
UBERON:0014490	biolink:AnatomicalEntity	middle phalanx of digit 4	A middle phalanx that is part of a digit 4 [Automatically generated definition].		hp.json	4th digit middle phalanx|intermediate phalanx of digit 4|fourth digit middle phalanx|fourth middle phalanx|middle phalanx of digit IV|middle phalanx of ring digit|intermediate phalanx of fourth digit|digit 4 intermediate phalanx|4th digit of intermediate phalanx|middle phalanx of 4th digit|middle phalanx of fourth digit|digit IV P2|digit 4 middle phalanx|4th digit intermediate phalanx|4th digit of middle phalanx|intermediate phalanx of 4th digit|fourth digit intermediate phalanx	http://purl.obolibrary.org/obo/UBERON_0014490		
UBERON:0014491	biolink:AnatomicalEntity	middle phalanx of digit 5	A middle phalanx that is part of a digit 5 [Automatically generated definition].		hp.json	fifth digit middle phalanx|middle phalanx of little digit|intermediate phalanx of digit 5|5th digit middle phalanx|fifth middle phalanx|5th digit of intermediate phalanx|middle phalanx of 5th digit|digit 5 intermediate phalanx|middle phalanx of fifth digit|fifth digit intermediate phalanx|intermediate phalanx of 5th digit|5th digit of middle phalanx|5th digit intermediate phalanx|digit 5 middle phalanx|digit V P2|middle phalanx of digit V|intermediate phalanx of fifth digit	http://purl.obolibrary.org/obo/UBERON_0014491		
GO:1900449	biolink:BiologicalProcess	regulation of glutamate receptor signaling pathway	Any process that modulates the frequency, rate or extent of glutamate receptor signaling pathway.		hp.json	regulation of glutamate signaling pathway|regulation of glutamate signalling pathway	http://purl.obolibrary.org/obo/GO_1900449		
HP:0031078	biolink:PhenotypicFeature	Impaired cortisol response to corticotropin releasing hormone stimulation test	Failure of cortisol levels to respond adequately (by increasing) to the corticotropin releasing hormone stimulation test.		hp.json		http://purl.obolibrary.org/obo/HP_0031078		
HP:0031079	biolink:PhenotypicFeature	Impaired growth-hormone response to insulin stimulation test	Failure of growth hormone levels to respond adequately (by increasing) to the insulin tolerance test (ITT).		hp.json		http://purl.obolibrary.org/obo/HP_0031079		
HP:0031074	biolink:PhenotypicFeature	Abnormal response to ACTH stimulation test	An anomolous response to stimulation by adminstration of the adrenocorticotropic hormone (ACTH). ACTH stimulation normally stimulates the adrenal glands to release cortisol and adrenaline.		hp.json	Abnormal response to adrenocorticotropic-hormone stimulation test|Abnormal response to corticotropin stimulation test	http://purl.obolibrary.org/obo/HP_0031074		
HP:0031075	biolink:PhenotypicFeature	Abnormal response to insulin tolerance test	An anomalous response to the insulin tolerance test (ITT), in which insulin is administered intravenously and blood glucose and potentially other compounds are measured at intervals. Insulin administration is intended to induce extreme hypoglycemia (bloodgluoce below 40 mg/dl), which in turn induces release of adrenocorticotropic hormone (ACTH) and growth hormone (GH). ACTH induces the adrenal gland to release cortisol, which together with GH opposes the action of insulin on the blood glucose level.		hp.json		http://purl.obolibrary.org/obo/HP_0031075		
CHEBI:37808	biolink:ChemicalSubstance	butane	A straight chain alkane composed of 4 carbon atoms.	Beilstein:969129|Reaxys:969129|PMID:24179026|PDBeChem:NBU|Gmelin:1148|Wikipedia:Butane|CAS:106-97-8|CAS:106-97-8	hp.json	butane|R-600|N-BUTANE|butane|E 943a|E-943a|n-C4H10|n-Butan|n-butane|E943a	http://purl.obolibrary.org/obo/CHEBI_37808		3_STAR
HP:0031076	biolink:PhenotypicFeature	Impaired cortisol response to insulin stimulation test	Failure of cortisol levels to respond adequately (by increasing) to the insulin tolerance test (ITT).		hp.json		http://purl.obolibrary.org/obo/HP_0031076		
HP:0031077	biolink:PhenotypicFeature	Abnormal response to corticotropin releasing hormone stimulation test	An anomalous response to the corticotropin releasing hormone (CRH) stimulation test. Normally,CRH is released by the hypothalamus to induce adrenocorticotropic hormone (ACTH) release by the anterior pituitary. In the stimulation test, CRH is administered intravenously and ACTH and cortisol are measured at intervals.		hp.json	Abnormal response to CRH stimulation test	http://purl.obolibrary.org/obo/HP_0031077		
CHEBI:84196	biolink:ChemicalSubstance	3-hydroxy fatty acid anion	A hydroxy fatty acid anion obtained by deprotonation of the carboxy group of any 3-hydroxy fatty acid.		hp.json	3-hydroxy fatty acid	http://purl.obolibrary.org/obo/CHEBI_84196		3_STAR
GO:0071312	biolink:BiologicalProcess	cellular response to alkaloid	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.		hp.json		http://purl.obolibrary.org/obo/GO_0071312		
GO:0071310	biolink:BiologicalProcess	cellular response to organic substance	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071310		
HP:0031081	biolink:PhenotypicFeature	Impaired cortisol response to glucagon stimulation test	Failure of cortisol levels to respond adequately (by increasing) to the glucagon stimulation test.		hp.json		http://purl.obolibrary.org/obo/HP_0031081		
HP:0031082	biolink:PhenotypicFeature	Impaired growth-hormone response to glucagon stimulation test	Failure of growth hormone levels to respond adequately (by increasing) to the glucagon stimulation test.		hp.json		http://purl.obolibrary.org/obo/HP_0031082		
UBERON:0014483	biolink:AnatomicalEntity	distal phalanx of digit 1	A distal phalanx that is part of a digit 1 [Automatically generated definition].		hp.json	distal phalanx of first digit|digit I P3|first distal phalanx|distal phalanx of digit I|digit 1 distal phalanx	http://purl.obolibrary.org/obo/UBERON_0014483		
HP:0031083	biolink:PhenotypicFeature	Abnormal response to human chorionic gonadotrophin stimulation test	An anomalous response to intravenous stimulation by human chorionic gonadotrophin. Stimulation with hCG stimulates testicular Leydig cells to secrete androgens via the Leydig hormone receptors.		hp.json	Abnormal response to hCG stimulation test	http://purl.obolibrary.org/obo/HP_0031083		
UBERON:0014484	biolink:AnatomicalEntity	distal phalanx of digit 2	A distal phalanx that is part of a digit 2 [Automatically generated definition].		hp.json	digit 2 distal phalanx|digit II P3|second digit distal phalanx|second distal phalanx|2nd digit distal phalanx|distal phalanx of second digit|distal phalanx of 2nd digit|distal phalanx of digit II|distal phalanx of index digit	http://purl.obolibrary.org/obo/UBERON_0014484		
HP:0031084	biolink:PhenotypicFeature	Excessive insulin response to glucagon test	An abnormally high increase in insulin levels following a glucagon stimulation test.		hp.json		http://purl.obolibrary.org/obo/HP_0031084		
HP:0031080	biolink:PhenotypicFeature	Abnormal response to glucagon stimulation test	An anomalous response to the glucagon stimulation test, which like the insulin tolerance test (ITT) stimulates the release of both adrenocorticotropic hormone (ACTH) and growth hormone (GH).		hp.json		http://purl.obolibrary.org/obo/HP_0031080		
UBERON:0014489	biolink:AnatomicalEntity	middle phalanx of digit 3	A middle phalanx that is part of a digit 3 [Automatically generated definition].		hp.json	3rd digit intermediate phalanx|middle phalanx of third digit|middle phalanx of digit III|digit 3 middle phalanx|third digit intermediate phalanx|middle phalanx of 3rd digit|3rd digit of intermediate phalanx|3rd digit middle phalanx|intermediate phalanx of third digit|third digit middle phalanx|middle phalanx of middle digit|intermediate phalanx of 3rd digit|3rd digit of middle phalanx|digit III P2|third middle phalanx|intermediate phalanx of digit 3|digit 3 intermediate phalanx	http://purl.obolibrary.org/obo/UBERON_0014489		
HP:0031089	biolink:PhenotypicFeature	Palatal edema	Swelling related to fluid accumulation within the palate.		hp.json	Palate oedema|Palatal oedema|Palate edema	http://purl.obolibrary.org/obo/HP_0031089		
GO:1900451	biolink:BiologicalProcess	positive regulation of glutamate receptor signaling pathway	Any process that activates or increases the frequency, rate or extent of glutamate receptor signaling pathway.		hp.json	up-regulation of glutamate signaling pathway|positive regulation of glutamate signalling pathway|up regulation of glutamate signaling pathway|up regulation of glutamate signalling pathway|positive regulation of glutamate signaling pathway|upregulation of glutamate receptor signaling pathway|up-regulation of glutamate signalling pathway|upregulation of glutamate signaling pathway|activation of glutamate signaling pathway|up regulation of glutamate receptor signaling pathway|activation of glutamate signalling pathway|upregulation of glutamate signalling pathway|up-regulation of glutamate receptor signaling pathway|activation of glutamate receptor signaling pathway	http://purl.obolibrary.org/obo/GO_1900451		
UBERON:0014485	biolink:AnatomicalEntity	distal phalanx of digit 3	A distal phalanx that is part of a digit 3. In odd-toes ungulates (Perissodactyla e.g. horses) this is called the coffin bone. In even-toed ungulates (Artiodactyla e.g cattle) this is associated with the medial claw.		hp.json	digit 3 distal phalanx|medial ungual phalanx of artiodactyl|pedal bone|digit III P3|3rd digit distal phalanx|equine 3rd phalanx of digit 3|third digit distal phalanx|medial claw of artiodactyl|distal phalanx of middle digit|equine distal phalanx|distal phalanx of third digit|third distal phalanx|medial claw of ruminant hoof|coffin bone|distal phalanx of digit III|distal phalanx of 3rd digit	http://purl.obolibrary.org/obo/UBERON_0014485		
HP:0031085	biolink:PhenotypicFeature	Decreased prealbumin level	A reduced concentration of prealbumin in the blood. Prealbumin, also known as transthyretin, has a half-life in plasma of about 2 days, much shorter than that of albumin. Prealbumin is therefore more sensitive to changes in protein-energy status than albumin, and its concentration closely reflects recent dietary intake rather than overall nutritional status.		hp.json		http://purl.obolibrary.org/obo/HP_0031085		
GO:1900450	biolink:BiologicalProcess	negative regulation of glutamate receptor signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of glutamate receptor signaling pathway.		hp.json	inhibition of glutamate signalling pathway|down regulation of glutamate receptor signaling pathway|inhibition of glutamate receptor signaling pathway|inhibition of glutamate signaling pathway|down-regulation of glutamate receptor signaling pathway|downregulation of glutamate signalling pathway|down-regulation of glutamate signaling pathway|negative regulation of glutamate signaling pathway|down regulation of glutamate signalling pathway|down regulation of glutamate signaling pathway|down-regulation of glutamate signalling pathway|negative regulation of glutamate signalling pathway|downregulation of glutamate receptor signaling pathway|downregulation of glutamate signaling pathway	http://purl.obolibrary.org/obo/GO_1900450		
UBERON:0014486	biolink:AnatomicalEntity	distal phalanx of digit 4	A distal phalanx that is part of a digit 4 [Automatically generated definition].		hp.json	digit 4 distal phalanx|distal phalanx of fourth digit|lateral ungual phalanx of artiodactyl|4th digit distal phalanx|lateral claw of artiodactyl|distal phalanx of 4th digit|fourth digit distal phalanx|lateral claw of ruminant hoof|fourth distal phalanx|distal phalanx of digit IV|distal phalanx of ring digit|digit IV P3	http://purl.obolibrary.org/obo/UBERON_0014486		
HP:0031086	biolink:PhenotypicFeature	Ectopic ovary	Undescended or ectopic ovaries are characterized by the attachment of the upper pole of the ovary to an area above the level of the common iliac vessels.		hp.json	Undescended ovary	http://purl.obolibrary.org/obo/HP_0031086		
UBERON:0014487	biolink:AnatomicalEntity	distal phalanx of digit 5	A distal phalanx that is part of a digit 5 [Automatically generated definition].		hp.json	distal phalanx of digit V|digit V P3|digit 5 distal phalanx|fifth digit distal phalanx|distal phalanx of little digit|distal phalanx of 5th digit|5th digit distal phalanx|fifth distal phalanx|distal phalanx of fifth digit	http://purl.obolibrary.org/obo/UBERON_0014487		
HP:0031087	biolink:PhenotypicFeature	Absent pubertal growth spurt	The abrupt and transient increase in the annual growth rate normally observed in adolescent individuals does not occur.		hp.json	Absent adolescent growth spurt	http://purl.obolibrary.org/obo/HP_0031087		
UBERON:0014488	biolink:AnatomicalEntity	middle phalanx of digit 2	A middle phalanx that is part of a digit 2 [Automatically generated definition].		hp.json	digit 2 middle phalanx|2nd digit intermediate phalanx|second digit middle phalanx|intermediate phalanx of second digit|2nd digit of middle phalanx|intermediate phalanx of 2nd digit|digit II P2|second middle phalanx|middle phalanx of index digit|2nd digit middle phalanx|middle phalanx of second digit|middle phalanx of digit II|intermediate phalanx of digit 2|digit 2 intermediate phalanx|second digit intermediate phalanx|middle phalanx of 2nd digit|2nd digit of intermediate phalanx	http://purl.obolibrary.org/obo/UBERON_0014488		
HP:0031088	biolink:PhenotypicFeature	Vaginal dryness	Persistent vaginal dryness.		hp.json		http://purl.obolibrary.org/obo/HP_0031088		
GO:0071345	biolink:BiologicalProcess	cellular response to cytokine stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071345		
HP:0031092	biolink:PhenotypicFeature	Spindle-shaped finger	Swelling of the hand at the knuckles, that gives the fingers a spindle shape (i.e., a round stick with tapered end and a broader base).		hp.json		http://purl.obolibrary.org/obo/HP_0031092		
HP:0031093	biolink:PhenotypicFeature	Abnormal breast morphology	Any anomaly of the structure of the breast.		hp.json		http://purl.obolibrary.org/obo/HP_0031093		
GO:0046394	biolink:BiologicalProcess	carboxylic acid biosynthetic process	The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.		hp.json	carboxylic acid synthesis|carboxylic acid formation|carboxylic acid biosynthesis|carboxylic acid anabolism	http://purl.obolibrary.org/obo/GO_0046394		
HP:0031094	biolink:PhenotypicFeature	Abnormal breast physiology	Any anomaly of the function of the breast.		hp.json		http://purl.obolibrary.org/obo/HP_0031094		
HP:0031095	biolink:PhenotypicFeature	Abnormal humerus morphology	Any anomaly of the structure of the humerus.		hp.json		http://purl.obolibrary.org/obo/HP_0031095		
CHEBI:25801	biolink:ChemicalSubstance	oxoproline	A pyrrolidinemonocarboxylic acid consisting of proline bearing a single oxo substituent.		hp.json	oxoproline	http://purl.obolibrary.org/obo/CHEBI_25801		3_STAR
HP:0031090	biolink:PhenotypicFeature	Finger dactylitis	Fingers appear swollen and plump owing to inflammation of the complete finger.		hp.json	Sausage fingers	http://purl.obolibrary.org/obo/HP_0031090		
HP:0031091	biolink:PhenotypicFeature	Toe dactylitis	Toes appear swollen and plump owing to inflammation of the complete toe.		hp.json	Sausage toes	http://purl.obolibrary.org/obo/HP_0031091		
UBERON:0014478	biolink:AnatomicalEntity	rib skeletal system	Subdivision of skeletal system that consists of all ribs and rib joints in an organism. In many vertebrates this consists of the combination of the rib cage and all rib joints, but some vertebrates have ribs outside the thoracic rib cage.	FMA:265719|TAO:0002100	hp.json	rib skeleton|rib series|set of all ribs	http://purl.obolibrary.org/obo/UBERON_0014478		
HP:0031096	biolink:PhenotypicFeature	Delayed vertebral ossification	A decrease in the amount of mineralized bone in one or more vertebrae compared with that expected for a given developmental age.		hp.json		http://purl.obolibrary.org/obo/HP_0031096		
HP:0031097	biolink:PhenotypicFeature	Abnormal thyroid-stimulating hormone level	Any deviation from the normal amount of the thyroid-stimulating hormone (TSH), which is produced by the anterior pituitary gland and stimulates the function of the thyroid gland.		hp.json	Abnormal thyrotropin level|Abnormal TSH level|Abnormal circulating thyrotropin concentration	http://purl.obolibrary.org/obo/HP_0031097		
HP:0031098	biolink:PhenotypicFeature	Decreased thyroid-stimulating hormone level	Reduced amount of the thyroid-stimulating hormone (TSH), which is produced by the anterior pituitary gland and stimulates the function of the thyroid gland.		hp.json	Decreased thyrotropin level|Decreased plasma TSH	http://purl.obolibrary.org/obo/HP_0031098		
HP:0031099	biolink:PhenotypicFeature	Abnormal circulating inhibin level	Any deviation from the normal concentration of inhibins, which are heterodimeric protein hormones secreted by granulosa cells of the ovary in females and Sertoli cells of the testis in males. Inhibins suppress the secretion of pituitary follicle-stimulating hormone.		hp.json		http://purl.obolibrary.org/obo/HP_0031099		
UBERON:0014477	biolink:AnatomicalEntity	thoracic skeleton	Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum.	EHDAA2:0002013|Wikipedia:Thoracic_skeleton|FMA:77169	hp.json	thoracic part of axial skeleton|thoracic skeleton|skeleton of thorax	http://purl.obolibrary.org/obo/UBERON_0014477		pheno_slim
UBERON:0002492	biolink:AnatomicalEntity	sagittal suture	The dense, fibrous connective tissue joint between the tetrapod parietal bones.	FMA:52929|MA:0002798|EMAPA:19224	hp.json	sagittal suture of skull|sutura sagittalis	http://purl.obolibrary.org/obo/UBERON_0002492		pheno_slim|uberon_slim
UBERON:0002491	biolink:AnatomicalEntity	lambdoid suture	The dense, fibrous connective tissue joint between the parietal bones and the occipital bone.	EMAPA:19227|MA:0002797|FMA:52933	hp.json	lambdoidal suture|sutura lambdoidea|lambdoid suture of skull	http://purl.obolibrary.org/obo/UBERON_0002491		pheno_slim|uberon_slim
UBERON:0002490	biolink:AnatomicalEntity	frontal suture	A suture that connects the two frontal bones of the skull.	EMAPA:35358|EMAPA:19226|FMA:52989|MA:0002796	hp.json	sutura frontalis|median frontal suture|sutura frontalis|sutura metopica|frontal suture of skull|metopic suture	http://purl.obolibrary.org/obo/UBERON_0002490		pheno_slim|uberon_slim
CHEBI:25806	biolink:ChemicalSubstance	oxygen molecular entity			hp.json	oxygen molecular entity|oxygen molecular entities	http://purl.obolibrary.org/obo/CHEBI_25806		3_STAR
UBERON:0002499	biolink:AnatomicalEntity	cochlear labyrinth	The labyrinth is a system of fluid passages in the inner ear, including both the cochlea, which is part of the auditory system, and the vestibular system, which provides the sense of balance. It is named by analogy with the mythical maze that imprisoned the Minotaur, because of its appearance. The bony labyrinth, or osseous labyrinth, is the network of passages with bony walls lined with periosteum. The bony labyrinth is lined with the membranous labyrinth. There is a layer of perilymph between them. The three parts of the bony labyrinth are the vestibule of the ear, the semicircular canals, and the cochlea. The vestibular system is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving. Joint and muscle receptors also are important in maintaining balance. The brain receives, interprets, and processes the information from these systems that control our balance. [WP,unvetted].	NCIT:C32336|FMA:61259|UMLS:C0931689|MA:0002809|EMAPA:36569|BTO:0004686	hp.json		http://purl.obolibrary.org/obo/UBERON_0002499		pheno_slim|uberon_slim
CHEBI:25805	biolink:ChemicalSubstance	oxygen atom		WebElements:O|KEGG:C00007	hp.json	Sauerstoff|8O|oxygene|oxygen|O|oxygen|oxigeno	http://purl.obolibrary.org/obo/CHEBI_25805		3_STAR
UBERON:0002495	biolink:AnatomicalEntity	long bone	A long bone is a bone that has a shaft and 2 ends and is longer than it is wide. Long bones have a thick outside layer of compact bone and an inner medullary cavity containing bone marrow.  The ends of a long bone contain spongy bone and an epiphyseal plate or line depending on the stage of development. The epiphyseal plate is a hyaline cartilage, where new bone growth takes place, lengthening the bone prior to adulthood. Bone lengthening ceases when this cartilage is lost, leaving a remnant referred to as an epiphyseal line.	OpenCyc:Mx4rv6axr5wpEbGdrcN5Y29ycA|NCIT:C33003|FMA:7474|EMAPA:35503|BTO:0004256|MA:0002802|galen:LongBone|UMLS:C0222647	hp.json	os longum	http://purl.obolibrary.org/obo/UBERON_0002495		pheno_slim|uberon_slim
UBERON:0002498	biolink:AnatomicalEntity	deltopectoral crest	A rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches.	FMA:23418|EMAPA:25052|MA:0002808|AAO:0000736	hp.json	deltoid tuberosity of humerus|tuberositas deltoidea humeri|pectoral process|deltoid crest|crista ventralis|tuberositas deltoidea|tuberositas deltoidea (corpus humeri)|deltoid process|deltoid impression|deltoid eminence|deltoid tuberosity|crista ventralis humeri	http://purl.obolibrary.org/obo/UBERON_0002498		pheno_slim|uberon_slim
UBERON:0002497	biolink:AnatomicalEntity	acromion	Region of the scapula where the latter meets with the clavicle: attachment point of the clavicle to the scapula in some taxa.	VSAO:0005067|NCIT:C32048|GAID:187|FMA:23260|EMAPA:25119|MESH:D000174|MA:0002805|UMLS:C0001209|OpenCyc:Mx4rvmrF8pwpEbGdrcN5Y29ycA|AAO:0000826	hp.json	acromion of the scapula|acromion process|acromion of scapula|scapular acromion	http://purl.obolibrary.org/obo/UBERON_0002497		pheno_slim|uberon_slim
HP:0031260	biolink:PhenotypicFeature	Triangular tibia	A short, dysplastic tibia with a triangular shape. Instead of the normal shaft configuration of the tibia, the tibia forms a triangle with the longest side corresponding to the proximal-distal dimension, and the apex of the triangle directed laterally.		hp.json		http://purl.obolibrary.org/obo/HP_0031260		
UBERON:0002515	biolink:AnatomicalEntity	periosteum	The thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints.	UMLS:C0031110|EMAPA:35681|MESH:D010521|FMA:24041|galen:PeriOsteum|GAID:925|MA:0002838|BTO:0001022|NCIT:C13184	hp.json		http://purl.obolibrary.org/obo/UBERON_0002515		uberon_slim|pheno_slim
UBERON:0002514	biolink:AnatomicalEntity	intramembranous bone	Bone tissue forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].	TAO:0001644|Wikipedia:Intramembranous_ossification|EMAPA:36615|ZFA:0001635	hp.json	membrane bone|intramembranous bones	http://purl.obolibrary.org/obo/UBERON_0002514		
UBERON:0002517	biolink:AnatomicalEntity	basicranium	The base of skull is the most inferior area of the skull, composed of the endocranium and lower parts of the skull roof.	MFMO:0000044|FMA:52801|MA:0002840|MESH:D019291|UMLS:C0149543|NCIT:C12493	hp.json	basis cranii|base of cranium|base of skull|cranial base	http://purl.obolibrary.org/obo/UBERON_0002517		uberon_slim|pheno_slim
UBERON:0002516	biolink:AnatomicalEntity	epiphyseal plate	A hyaline cartilage plate in the metaphysis at each end of a long bone. The plate is found in children and adolescents; in adults, who have stopped growing, the plate is replaced by an epiphyseal line.	MESH:D006132|FMA:75427|BTO:0000412|EMAPA:35505|MA:0002839|GAID:191	hp.json	epiphyseal disk|epiphysial plate|physis|cartilago epiphysialis|epiphyseal growth plate|epiphyseal growth disk|long bone epiphyseal plate|epiphyseal growth plate cartilage|lamina epiphysialis|epiphyseal cartilage|growth plate	http://purl.obolibrary.org/obo/UBERON_0002516		uberon_slim|pheno_slim
HP:0031265	biolink:PhenotypicFeature	Abnormal glomerular visceral epithelial cell morphology	Any structural anomaly of the podocyte, which is a highly specialized cell of the Bowman capsule and which forms multiple interdigitating foot processes. Podocytes are interconnected by slit diaphragms and cover the exterior basement membrane surface of the glomerular capillary.		hp.json	Abnormal podocyte morphology|Abnormal visceral epithelial cell morphology	http://purl.obolibrary.org/obo/HP_0031265		
HP:0031266	biolink:PhenotypicFeature	Podocyte foot process effacement	An anomaly of podocyte morphology characterized by the loss of the interdigitating foot process pattern (generally called foot process effacement; FPE). The term FPE designates the loss of the usual interdigitating pattern of foot processes of neighboring podocytes, leading to relatively broad expanses of podocyte processes covering the glomerular basement membrane (GBM). It is widely viewed as a pathological derangement that is associated with leakage of macromolecules such as albumin through the glomerular filtration barrier.		hp.json	Loss of primary podocyte processes	http://purl.obolibrary.org/obo/HP_0031266		
UBERON:0014501	biolink:AnatomicalEntity	proximal phalanx of digit 1	A proximal phalanx that is part of a autopod digit 1 [Automatically generated definition].		hp.json	digit I-1|digit I P1|proximal phalanx of first digit of autopod|first proximal phalanx of autopod|proximal phalanx of digit I	http://purl.obolibrary.org/obo/UBERON_0014501		
HP:0031267	biolink:PhenotypicFeature	Abnormal CD69 upregulation upon TCR activation	Any abnormality in the upregulation of CD69 on T cells after activation via the T cell receptor (TCR). Upregulation of CD69 is one of the earliest and most sensitive measures of antigen recognition in the periphery, and transient expression of CD69 is associated with positive selection in the thymus.		hp.json		http://purl.obolibrary.org/obo/HP_0031267		
UBERON:0014502	biolink:AnatomicalEntity	proximal phalanx of digit 2	A proximal phalanx that is part of a autopod digit 2 [Automatically generated definition].		hp.json	second proximal phalanx of autopod|2nd digit proximal phalanx|autopod digit 2 proximal phalanx|proximal phalanx of second digit|proximal phalanx of digit II|digit II-1|proximal phalanx of 2nd digit|2nd digit of autopod proximal phalanx|proximal phalanx of index digit|proximal phalanx of 2nd digit of autopod|digit IU P1|proximal phalanx of second digit of autopod|second digit proximal phalanx	http://purl.obolibrary.org/obo/UBERON_0014502		
UBERON:0014503	biolink:AnatomicalEntity	proximal phalanx of digit 3	A proximal phalanx that is part of a autopod digit 3 [Automatically generated definition].		hp.json	3rd digit proximal phalanx|third digit proximal phalanx|proximal phalanx of middle digit|digit III-1|autopod digit 3 proximal phalanx|digit III P1|proximal phalanx of third digit|proximal phalanx of digit III|3rd digit of autopod proximal phalanx|proximal phalanx of 3rd digit|proximal phalanx of 3rd digit of autopod|proximal phalanx of third digit of autopod|third proximal phalanx of autopod	http://purl.obolibrary.org/obo/UBERON_0014503		
HP:0031268	biolink:PhenotypicFeature	Decreased CD69 upregulation upon TCR activation	Reduced or impaired upregulation of CD69 on T cells after activation via the T cell receptor (TCR).		hp.json		http://purl.obolibrary.org/obo/HP_0031268		
CHEBI:62761	biolink:ChemicalSubstance	tyrosine derivative	An amino acid derivative resulting from reaction of tyrosine at the amino group or the carboxy group, any substitution of phenyl hydrogens, or from the replacement of any hydrogen of tyrosine by a heteroatom. The definition normally excludes peptides containing tyrosine residues.		hp.json	tyrosine derivatives	http://purl.obolibrary.org/obo/CHEBI_62761		3_STAR
HP:0031261	biolink:PhenotypicFeature	Bladder polyp	An abnormal growth that projects from the mucous membrane of the urinary bladder.		hp.json		http://purl.obolibrary.org/obo/HP_0031261		
HP:0031263	biolink:PhenotypicFeature	Abnormal renal corpuscle morphology	Any anomolous structure of the renal corpuscle, which is the initial component of the nephron that filters blood. The renal corpuscle consists of a knot of capillaries (glomerulus) that is surrounded by a double-walled capsule (Bowman capsule) that opens into a renal tubule.		hp.json		http://purl.obolibrary.org/obo/HP_0031263		
HP:0031264	biolink:PhenotypicFeature	Abnormal Bowman capsule morphology	A structural anomaly of the double-walled capsule (Bowman capsule) that opens into a renal tubule.		hp.json	Abnormal morphology of Bowman capsule|Abnormal morphology of Bowman's capsule|Abnormal renal glomerular capsule morphology	http://purl.obolibrary.org/obo/HP_0031264		
CHEBI:35134	biolink:ChemicalSubstance	metalloprotein		COMe:PRX000002	hp.json	metalloprotein|metalloproteine|metalloproteins	http://purl.obolibrary.org/obo/CHEBI_35134		3_STAR
CHEBI:35137	biolink:ChemicalSubstance	hemoprotein	Conjugated proteins containing heme as the prosthetic group.	COMe:PRX000008	hp.json	haem protein|haemoprotein|Haemoprotein|Haemprotein|hemeproteins|hemoproteins|hemoprotein|heme protein	http://purl.obolibrary.org/obo/CHEBI_35137		3_STAR
CHEBI:35136	biolink:ChemicalSubstance	iron protein		COMe:PRX000004	hp.json	iron protein|iron-containing proteins|iron proteins	http://purl.obolibrary.org/obo/CHEBI_35136		3_STAR
HP:0031269	biolink:PhenotypicFeature	Abnormal CD25 upregulation upon TCR activation	Any abnormality in the upregulation of CD25 on T cells after activation via the T cell receptor (TCR). CD25 is the alpha chain of the IL2 receptor. Ligation of the T cell antigen receptor leads to the induction of CD25 expression.		hp.json		http://purl.obolibrary.org/obo/HP_0031269		
UBERON:0002522	biolink:AnatomicalEntity	tunica media	The middle layer of an artery or vein. [WP,unvetted].	FMA:55590|GAID:170|SCTID:61695000|MESH:D017540|UMLS:C0162867|Wikipedia:Tunica_media|BTO:0002011|MA:0002855|NCIT:C33821|EMAPA:36298	hp.json	tunica media vasorum|tunica media vasorum|tunica media vasorum	http://purl.obolibrary.org/obo/UBERON_0002522		uberon_slim
HP:0006298	biolink:PhenotypicFeature	Prolonged bleeding after dental extraction	Prolonged bleeding post dental extraction sufficient to require medical intervention.	UMLS:C1969572	hp.json	Prolonged bleeding after dental extraction	http://purl.obolibrary.org/obo/HP_0006298		
UBERON:0002521	biolink:AnatomicalEntity	elastic tissue	Connective tissue composed of elastic fibers.	MESH:D004547|GAID:926|NCIT:C32495|SCTID:27197004|FMA:20113|Wikipedia:Elastic_fiber|MA:0002853	hp.json	elastic connective tissue|textus connectivus elasticus|elastic fiber	http://purl.obolibrary.org/obo/UBERON_0002521		uberon_slim
UBERON:0002523	biolink:AnatomicalEntity	tunica intima	The innermost layer of a blood vessel which is a lining of endothelial cells facing the lumen[Kardong].	EMAPA:36297|NCIT:C33820|MESH:D017539|MA:0002861|FMA:55589|UMLS:C0162864|BTO:0002012|SCTID:87483006|SCTID:8361002|GAID:523|Wikipedia:Tunica_intima	hp.json	Bichat's tunic|intima|tunica intima vasorum	http://purl.obolibrary.org/obo/UBERON_0002523		uberon_slim
HP:0006297	biolink:PhenotypicFeature	Enamel hypoplasia	Developmental hypoplasia of the dental enamel.	UMLS:C4280457|UMLS:C4280456|SNOMEDCT_US:699382004|UMLS:C0011351|SNOMEDCT_US:699421005|MSH:D003744|UMLS:C1851854|SNOMEDCT_US:26597004	hp.json	Enamel dysplasia|Hypoplasia of dental enamel|Defective enamel matrix|Thin tooth enamel|Dysplasia of tooth enamel|Enamel hypotrophy|Enamel, underdeveloped|Thin dental enamel|Underdeveloped teeth enamel|Dental enamel hypoplasia|Hypoplasia of tooth enamel	http://purl.obolibrary.org/obo/HP_0006297		
CHEBI:37793	biolink:ChemicalSubstance	amino sulfonic acid	An organosulfonic acid containing one or more amino groups.		hp.json	amino sulfonic acids|aminosulfonic acid|aminosulfonic acids	http://purl.obolibrary.org/obo/CHEBI_37793		3_STAR
UBERON:0002507	biolink:AnatomicalEntity	abdominal lymph node	A lymph node that is part of an abdomen [Automatically generated definition].	EMAPA:35992|FMA:12787|MA:0002827	hp.json	abdomen lymph node|parietal abdominal lymph node|lymph node of abdomen	http://purl.obolibrary.org/obo/UBERON_0002507		pheno_slim
HP:0031270	biolink:PhenotypicFeature	Decreased CD25 upregulation upon TCR activation	Decreased or impaired upregulation of CD25 on T cells after activation via the T cell receptor (TCR).		hp.json	Poor CD25 upregulation upon TCR activation|Reduced IL2RA upregulation upon TCR activation	http://purl.obolibrary.org/obo/HP_0031270		
UBERON:0002509	biolink:AnatomicalEntity	mesenteric lymph node	The lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group.	UMLS:C0229792|FMA:12795|EMAPA:35561|BTO:0000767|NCIT:C77641|MA:0002829	hp.json	nodi lymphoidei mesenterici|mesenteric node	http://purl.obolibrary.org/obo/UBERON_0002509		pheno_slim
HP:0031271	biolink:PhenotypicFeature	Absent ankle pulse	The pulsation of the posterior tibial artery behind the internal malleolus, or of the dorsalis pedis artery, cannot be detected on physical examination.		hp.json		http://purl.obolibrary.org/obo/HP_0031271		
UBERON:0002504	biolink:AnatomicalEntity	lesser trochanter	The lesser trochanter (small trochanter) of the femur is a conical eminence, which varies in size in different subjects [WP,unvetted].	MA:0002823|NCIT:C32982|UMLS:C0223866|FMA:32853|EMAPA:37595|galen:LesserTrochanter	hp.json	trochanter minor|lesser trochanter of femur	http://purl.obolibrary.org/obo/UBERON_0002504		uberon_slim|pheno_slim
UBERON:0002503	biolink:AnatomicalEntity	greater trochanter	The greater trochanter (great trochanter) of the femur is a large, irregular, quadrilateral eminence and a part of the skeletal system. It is directed a little lateralward and backward, and, in the adult, is about 1 cm lower than the head. Because the pelvic outlet in the female is larger than in the male, there is a greater distance between the greater trochanters in the female. It has two surfaces and four borders. [WP,unvetted].	MA:0002822|NCIT:C32698|galen:GreaterTrochanter|UMLS:C0223865|FMA:32852|EMAPA:37594	hp.json	great trochanter|greater trochanter of femur|trochanter major	http://purl.obolibrary.org/obo/UBERON_0002503		uberon_slim
UBERON:0002506	biolink:AnatomicalEntity	iris epithelium	An epithelium that is part of a iris [Automatically generated definition].	FMA:58517|EMAPA:35447|MA:0002826	hp.json	iris pigmented epithelium|pigmented epithelium of iris|iris epithelium|epithelium pigmentosum iridis|iris epithelial tissue|epithelium pigmentosum (iris)|epithelial tissue of iris|epithelium of iris	http://purl.obolibrary.org/obo/UBERON_0002506		pheno_slim|human_reference_atlas
HP:0031276	biolink:PhenotypicFeature	Obstructive shock	A type of shock characterized by inadequate cardiac preload due to obstructed venous return (e.g. pericardial tamponade, tension pneumothorax, abdominal compartment) or obstruction of arterial blood flow (e.g. pulmonary embolism).		hp.json		http://purl.obolibrary.org/obo/HP_0031276		
HP:0031278	biolink:PhenotypicFeature	Abnormal thoracic duct morphology	Any structural anomaly of the thoracic duct.		hp.json		http://purl.obolibrary.org/obo/HP_0031278		
HP:0031279	biolink:PhenotypicFeature	Abnormal response to gonadotropin-releasing hormone stimulation test	An abnormal response to the gonadotropin-releasing hormone (GnRH) stimulation test. This test typically involves intravenous administration of GnRH followed by repeated blood sampling at various time points to measure the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).		hp.json	Abnormal response to GnRH stimulation test	http://purl.obolibrary.org/obo/HP_0031279		
HP:0031272	biolink:PhenotypicFeature	Pulmonary arterial atherosclerosis	Accumulation of lipids and inflammatory cells along the inner walls of the pulmonary artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031272		
HP:0031273	biolink:PhenotypicFeature	Shock	The state in which profound and widespread reduction of effective tissue perfusion leads first to reversible, and then if prolonged, to irreversible cellular injury.		hp.json		http://purl.obolibrary.org/obo/HP_0031273		
HP:0031274	biolink:PhenotypicFeature	Hypovolemic shock	A state of shock characterized by decreased circulating blood volume in relation to total vascular capacity. This type of shock is characterized by a reduction of diastolic filling pressures.		hp.json		http://purl.obolibrary.org/obo/HP_0031274		
HP:0031275	biolink:PhenotypicFeature	Distributive shock	A hyperdynamic process resulting from excessive vasodilatation. Impaired blood flow causes inadequate tissue perfusion, which can lead to end-organ damage		hp.json		http://purl.obolibrary.org/obo/HP_0031275		
UBERON:0002510	biolink:AnatomicalEntity	anterior fontanel	In humans, the anterior fontanelle (bregmatic fontanelle, frontal fontanelle) is the largest, and is placed at the junction of the sagittal suture, coronal suture, and frontal suture; it is lozenge-shaped, and measures about 4 cm in its antero-posterior and 2.5 cm in its transverse diameter. The fontanelle allows the skull to deform during birth to ease its passage through the birth canal and for expansion of the brain after birth. While the posterior and lateral fontanelles are obliterated by about six months after birth, the anterior is not completely closed until about the middle of the second year. Full ossification starts in the late twenties and finishes before the age of 50 . [WP,unvetted].	MA:0002830|FMA:75439|EMAPA:19199	hp.json	anterior fontanelle|frontal fontanelle|fonticulus anterior|bregmatic fontanelle	http://purl.obolibrary.org/obo/UBERON_0002510		pheno_slim
UBERON:0002513	biolink:AnatomicalEntity	endochondral bone	Replacement bone that forms within cartilage.	EHDAA2:0003083|XAO:0004018|AEO:0000083|AAO:0010776|ZFA:0001591|TAO:0001591|BTO:0002157|VSAO:0000145|FMA:24321	hp.json	cartilaginous bone|endochondral bones|ossified chondrogenic bone	http://purl.obolibrary.org/obo/UBERON_0002513		vertebrate_core|uberon_slim
CHEBI:35143	biolink:ChemicalSubstance	hemoglobin		COMe:PRX000321	hp.json	hemoglobin|vertebrate haemoglobin|haemoglobin	http://purl.obolibrary.org/obo/CHEBI_35143		3_STAR
CHEBI:25798	biolink:ChemicalSubstance	oxopentanoates	The conjugate base of any oxopentanoic acid.		hp.json	oxopentanoate	http://purl.obolibrary.org/obo/CHEBI_25798		3_STAR
HP:0031280	biolink:PhenotypicFeature	Increased LH response to gonadotropin-releasing hormone stimulation test	An abnormally high amount of luteinizing hormone (LH) is released upon gonadotropin-releasing hormone stimulation test.		hp.json		http://purl.obolibrary.org/obo/HP_0031280		
HP:0006280	biolink:PhenotypicFeature	Chronic pancreatitis	A chronic form of pancreatitis.	MSH:D050500|UMLS:C0149521|SNOMEDCT_US:235494005|SNOMEDCT_US:234689009|SNOMEDCT_US:233870001	hp.json	Chronic pancreas inflammation	http://purl.obolibrary.org/obo/HP_0006280		
HP:0031281	biolink:PhenotypicFeature	Sialadenitis	Inflammation of a salivary gland.		hp.json		http://purl.obolibrary.org/obo/HP_0031281		
HP:0031282	biolink:PhenotypicFeature	Malalignment of the great toenail	A lateral deviation of the nail plate of the great toe along the longitudinal axis due to the lateral rotation of the nail matrix. The nail plate grows out in ridges.		hp.json		http://purl.obolibrary.org/obo/HP_0031282		
HP:0006282	biolink:PhenotypicFeature	Generalized hypoplasia of dental enamel	A generalized form of developmental hypoplasia of the dental enamel.	UMLS:C4025070|UMLS:C4280462	hp.json	Generalized hypoplasia of tooth enamel|Generalised hypoplasia of tooth enamel|Generalised dysplasia of tooth enamel|Generalized dysplasia of tooth enamel|Generalised hypoplasia of dental enamel	http://purl.obolibrary.org/obo/HP_0006282		
CHEBI:25799	biolink:ChemicalSubstance	oxopentanoic acid	A C5 fatty acid carrying an oxo group at any position.		hp.json	oxopentanoic acid|oxovaleric acid	http://purl.obolibrary.org/obo/CHEBI_25799		3_STAR
HP:0031287	biolink:PhenotypicFeature	Seborrheic keratosis	A raised growth on the skin of older individuals. The lesion usually is initially light tan and may darken to dark brown or nearly black. The consistent feature of seborrheic keratoses is their waxy, pasted-on or stuck-on look.		hp.json	Senile wart|Basal cell papilloma|Seborrheic verruca	http://purl.obolibrary.org/obo/HP_0031287		
HP:0031288	biolink:PhenotypicFeature	Cobblestone-like hyperkeratosis	The presence of verrucous, cobblestone-like papules and nodules in a region of skin that is said to have an appearance like that of cobblestones.		hp.json		http://purl.obolibrary.org/obo/HP_0031288		
HP:0031289	biolink:PhenotypicFeature	White papule	A papule with white color.		hp.json		http://purl.obolibrary.org/obo/HP_0031289		
HP:0031283	biolink:PhenotypicFeature	Tufted hairs	The presence of tufts of 8-15 hairs that appear to emerge from a single follicular orifice.		hp.json		http://purl.obolibrary.org/obo/HP_0031283		
HP:0031284	biolink:PhenotypicFeature	Flushing	Recurrent episodes of redness of the skin together with a sensation of warmth or burning of the affected areas of skin.		hp.json		http://purl.obolibrary.org/obo/HP_0031284		
HP:0031285	biolink:PhenotypicFeature	Abnormal perifollicular morphology	Any structural anomaly in the areas surrounding the hair follicles.		hp.json		http://purl.obolibrary.org/obo/HP_0031285		
HP:0031286	biolink:PhenotypicFeature	Perifollicular erythema	Redness surrounding the hair follicles.		hp.json		http://purl.obolibrary.org/obo/HP_0031286		
UBERON:0002500	biolink:AnatomicalEntity	zygomatic arch	The bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone.	MA:0002810|OpenCyc:Mx4rvih1YZwpEbGdrcN5Y29ycA|MESH:D015050|NCIT:C33897|EMAPA:36570|galen:Zygoma|MFMO:0000108|UMLS:C0162485|FMA:53120	hp.json	zygoma|arcus zygomaticus	http://purl.obolibrary.org/obo/UBERON_0002500		pheno_slim|uberon_slim
HP:0006276	biolink:PhenotypicFeature	Hyperechogenic pancreas		UMLS:C1857945	hp.json		http://purl.obolibrary.org/obo/HP_0006276		
HP:0006277	biolink:PhenotypicFeature	Pancreatic hyperplasia	Hyperplasia of the pancreas.	UMLS:C1851733	hp.json		http://purl.obolibrary.org/obo/HP_0006277		
HP:0006278	biolink:PhenotypicFeature	Ectopic pancreatic tissue	The presence of pancreatic tissue outside the normal pancreas, in many cases along the foregut and proximal midgut.	SNOMEDCT_US:264304000|UMLS:C0994638	hp.json	Abnormal pancreas location	http://purl.obolibrary.org/obo/HP_0006278		
HP:0006279	biolink:PhenotypicFeature	Beta-cell dysfunction		UMLS:C1969875	hp.json		http://purl.obolibrary.org/obo/HP_0006279		
HP:0006273	biolink:PhenotypicFeature	Pancreatic lymphangiectasis	The presence of lymphangiectasis in the pancreas.	UMLS:C1856162	hp.json		http://purl.obolibrary.org/obo/HP_0006273		
HP:0006274	biolink:PhenotypicFeature	Reduced pancreatic beta cells	Reduced number of beta cells in the pancreatic islets of Langerhans.	UMLS:C1856904	hp.json		http://purl.obolibrary.org/obo/HP_0006274		
HP:0031290	biolink:PhenotypicFeature	Tuberous xanthoma	A type of xanthoma characterized by a nodular form. Tuberous xanthomas are firm subcutaneous nodules,whereby the overlying skin can have red or red-yellow color changes.		hp.json		http://purl.obolibrary.org/obo/HP_0031290		
HP:0006290	biolink:PhenotypicFeature	Discolored lateral incisors	The presence of discolored lateral incisors.	UMLS:C1866510|UMLS:C4280459	hp.json	Discoloured lateral incisors|Abnormality of colour of lateral incisor|Abnormality of color of lateral incisor|Abnormality of colour of front teeth|Discolored front teeth|Abnormality of color of front teeth|Discoloured front teeth|Abnormality of shade of lateral incisor	http://purl.obolibrary.org/obo/HP_0006290		
HP:0031291	biolink:PhenotypicFeature	Ichthyosis follicularis	Ichthyosis follicularis is characterized by widespread non inflammatory thorn-like follicular projections. Dyskeratotic papules are most pronounced over the extensor extremities and scalp and are symmetrically distributed.		hp.json		http://purl.obolibrary.org/obo/HP_0031291		
HP:0006291	biolink:PhenotypicFeature	Marked delay in eruption of permanent teeth		UMLS:C1863009	hp.json	Severe delay of eruption of permanent teeth|Very late eruption of permanent teeth|Very late eruption of adult teeth|Severe delay of eruption of adult teeth	http://purl.obolibrary.org/obo/HP_0006291		
HP:0031292	biolink:PhenotypicFeature	Cutaneous abscess	A circumscribed area of pus or necrotic debris in the skin.		hp.json	Skin abscess	http://purl.obolibrary.org/obo/HP_0031292		
HP:0006292	biolink:PhenotypicFeature	Abnormality of dental eruption	An abnormality of tooth eruption.	SNOMEDCT_US:1086101000119107|SNOMEDCT_US:234949000|UMLS:C0012767|UMLS:C1859363|UMLS:C3874458	hp.json	Disturbance of dental eruption|Abnormal dental eruption|Disorder of dental eruption|Anomaly of tooth eruption|Disturbance of tooth eruption|Anomaly of dental eruption|Disorder of tooth eruption|Abnormality of tooth eruption	http://purl.obolibrary.org/obo/HP_0006292		
HP:0031293	biolink:PhenotypicFeature	Digital pitting scar	Pinhole-sized concave depressions with hyperkeratosis in the skin of a finger or toe.		hp.json		http://purl.obolibrary.org/obo/HP_0031293		
HP:0006293	biolink:PhenotypicFeature	Agenesis of maxillary central incisor	Agenesis of upper secondary incisor or of upper central primary incisor.	UMLS:C4025068|UMLS:C4280458	hp.json	Absence of maxillary central incisor|Missing maxillary central incisor|Failure of development of maxillary central incisor|Missing upper central incisor	http://purl.obolibrary.org/obo/HP_0006293		
CHEBI:50745	biolink:ChemicalSubstance	progestogen	A compound that interacts with progesterone receptors in target tissues to bring about effects similar to those of progesterone.		hp.json	gestagens|gestagen|progestagen|progestagens|progestogens	http://purl.obolibrary.org/obo/CHEBI_50745		3_STAR
HP:0031298	biolink:PhenotypicFeature	Coronary sinus enlargement	Abnormal increase in size of the coronary sinus.		hp.json	Enlarged coronary sinus|Coronary sinus dilatation	http://purl.obolibrary.org/obo/HP_0031298		
HP:0031299	biolink:PhenotypicFeature	Elevated left atrial pressure	An abnormal increase in magnitude of the pressure in the left atrium.		hp.json		http://purl.obolibrary.org/obo/HP_0031299		
CHEBI:50748	biolink:ChemicalSubstance	antipsoriatic	A drug used to treat psoriasis.		hp.json	antipsoriatic agent|antipsoriatic drug	http://purl.obolibrary.org/obo/CHEBI_50748		3_STAR
HP:0031294	biolink:PhenotypicFeature	Hypoplastic right atrium	Underdeveloped, small right heart atrium.		hp.json		http://purl.obolibrary.org/obo/HP_0031294		
HP:0031295	biolink:PhenotypicFeature	Left atrial enlargement	Increase in size of the left atrium.	Fyler:3011|Fyler:3020	hp.json	Enlarged heart left atrium	http://purl.obolibrary.org/obo/HP_0031295		
HP:0031296	biolink:PhenotypicFeature	Atrial septal hypertrophy	An abnormal increase in the thickness of the atrial septum.		hp.json		http://purl.obolibrary.org/obo/HP_0031296		
HP:0031297	biolink:PhenotypicFeature	Unroofed coronary sinus	Unroofed coronary sinus (CS) is a rare congenital cardiac anomaly in which there is partial (either focal or fenestrated) or complete absence of the roof of the CS, which results in a communication between the CS and the LA. Unroofed CS is the rarest type of atrial septal defect. It is often associated with persistent left superior vena cava (LSVC) and other forms of complex congenital heart disease, usually heterotaxia syndromes. The morphological types have been classified into 4 groups: Type I, completely unroofed with persistent LSVC; type II, completely unroofed without persistent LSVC; type III, partially unroofed mid portion; and type IV, partially unroofed terminal portion.		hp.json		http://purl.obolibrary.org/obo/HP_0031297		
CHEBI:37786	biolink:ChemicalSubstance	acyclic phosphorus acid anhydride			hp.json	acyclic phosphorus acid anhydrides	http://purl.obolibrary.org/obo/CHEBI_37786		3_STAR
HP:0006288	biolink:PhenotypicFeature	Advanced eruption of teeth	Premature tooth eruption, which can be defined as tooth eruption more than 2 SD earlier than the mean eruption age.	UMLS:C0266054|SNOMEDCT_US:16000003	hp.json	Early eruption of teeth|Premature eruption of teeth|Premature tooth eruption|Early dental eruption|Advanced dental eruption|Eruption, advanced|Advanced tooth eruption|Premature dental eruption	http://purl.obolibrary.org/obo/HP_0006288		
HP:0006289	biolink:PhenotypicFeature	Agenesis of central incisor	Agenesis of one or more central incisors, i.e., of lower secondary incisor, lower primary incisor, upper secondary incisor, or of upper central primary incisor.	UMLS:C1855000|UMLS:C4020819	hp.json	Missing central incisors|Absent central incisors|Failure of development of central incisor|Absent central incisor	http://purl.obolibrary.org/obo/HP_0006289		
HP:0006283	biolink:PhenotypicFeature	Multiple unerupted teeth	The presence of multiple embedded tooth germs which have failed to erupt.	UMLS:C4025069	hp.json	Failure of eruption of multiple teeth|Multiple non-erupting teeth|Multiple unerupted teeth	http://purl.obolibrary.org/obo/HP_0006283		
HP:0006285	biolink:PhenotypicFeature	Enamel hypomineralization	A decreased amount of enamel mineralization. Hypomineralized enamel has a brown discoloration and brittle aspect.	SNOMEDCT_US:109487003|UMLS:C4280253|UMLS:C3665628|UMLS:C4280461|UMLS:C4280460	hp.json	Decreased enamel mineralisation|Mottled tooth enamel|Fluorosis of tooth enamel|Poorly mineralized tooth enamel|Increased porosity of tooth enamel|White spot lesions of tooth enamel|Hypomineralization of enamel	http://purl.obolibrary.org/obo/HP_0006285		
HP:0006286	biolink:PhenotypicFeature	Yellow-brown discoloration of the teeth		UMLS:C1863008	hp.json	Yellow-brown tooth shade|Yellow-brown discoloration of the teeth|Yellow-brown discolored teeth|Yellow-brown discoloured teeth	http://purl.obolibrary.org/obo/HP_0006286		
CHEBI:23117	biolink:ChemicalSubstance	chlorine molecular entity	A halogen molecular entity containing one or more atoms of chlorine.		hp.json		http://purl.obolibrary.org/obo/CHEBI_23117		3_STAR
UBERON:0002558	biolink:AnatomicalEntity	organ cavity		BIRNLEX:1019|FMA:12237|SCTID:362606005	hp.json	cavity of organ	http://purl.obolibrary.org/obo/UBERON_0002558		upper_level
CHEBI:50733	biolink:ChemicalSubstance	nutraceutical	A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.		hp.json	Nutritional supplement|Dietary Supplement|Food Supplementation	http://purl.obolibrary.org/obo/CHEBI_50733		3_STAR
CHEBI:23116	biolink:ChemicalSubstance	chlorine atom		WebElements:Cl	hp.json	chlore|Cl|Chlor|chlorine|chlorine|cloro|chlorum|17Cl	http://purl.obolibrary.org/obo/CHEBI_23116		3_STAR
HP:0033884	biolink:PhenotypicFeature	Abnormal cortical radial artery lumen morphology	Abnormal structural characteristics of the interior space of the cortical radial arteries of the kidney.		hp.json	Abnormal interlobular arterial lumen morphology	http://purl.obolibrary.org/obo/HP_0033884		
HP:0031221	biolink:PhenotypicFeature	Abnormal radioactive iodine uptake test result	Any deviation from normal in the amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker.		hp.json		http://purl.obolibrary.org/obo/HP_0031221		
HP:0033883	biolink:PhenotypicFeature	Abnormal cortical radial artery morphology	Any structural anomaly of the radial arteries that branch off at right angles from the arcuate artery and carry blood toward the cortex of the kidney.		hp.json	Abnormal interlobular artery morphology	http://purl.obolibrary.org/obo/HP_0033883		
HP:0031222	biolink:PhenotypicFeature	Increased circulating thyroxine-binding globulin level	An elevated concentration of thyroxine-binding globulin (TBG) in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031222		
HP:0033886	biolink:PhenotypicFeature	Abnormal arcuate artery intima/media morphology	Anomalous structure of the inner or middle layer of the arc-shaped arteries located at the border of the renal cortex and renal medulla.		hp.json	Abnormalities of the arcuate arterial intima/media	http://purl.obolibrary.org/obo/HP_0033886		
HP:0031223	biolink:PhenotypicFeature	Focal pancreatic islet hyperplasia	Hyperplasia of the islets of Langerhans that affects only certain regions of the pancreas and not others.		hp.json		http://purl.obolibrary.org/obo/HP_0031223		
HP:0031224	biolink:PhenotypicFeature	Diffuse pancreatic islet hyperplasia	Hyperplasia of the islets of Langerhans with a generalized distribution.		hp.json		http://purl.obolibrary.org/obo/HP_0031224		
UBERON:0014547	biolink:AnatomicalEntity	sacral division of spinal cord central canal	Part of spinal cord central canal contained in the sacral spinal cord. It is continuous rostrally with the spinal cord central canal of the lumbar cord.	FMA:321696|NLXANAT:1010008	hp.json	sacral spinal cord central canal|lumbosacral spinal cord central canal	http://purl.obolibrary.org/obo/UBERON_0014547		
HP:0033885	biolink:PhenotypicFeature	Cortical radial artery lumen cholesterol emboli	Needle-like or slit-like clefts within the interior space of cortical radial arteries (interlobular arteries) of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.		hp.json		http://purl.obolibrary.org/obo/HP_0033885		
UBERON:0014540	biolink:AnatomicalEntity	white matter lamina of cerebellum	The white laminae of cerebellum is subdivision of the cerebellar cortex comprised of myelinated axons lying deep to the granule cell layer of the cerebellar cortex.	BIRNLEX:1105|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=163|UMLS:C0228472	hp.json	white laminae of cerebellum|isthmus gyri cingulatus|white lamina of cerebellum|laminae albae of cerebellar cortex|laminae albae of cerebellar cortex|isthmus of the cingulate gyrus|isthmus of gyrus fornicatus|isthmus-2|lamina alba of cerebellar cortex|isthmus cinguli|isthmus gyri cinguli	http://purl.obolibrary.org/obo/UBERON_0014540		
PATO:0000569	biolink:NamedThing	decreased height	A height which is relatively low.		hp.json	short	http://purl.obolibrary.org/obo/PATO_0000569		value_slim
HP:0033880	biolink:PhenotypicFeature	Arcuate vein intimal mucoid edema	Accumulation of edematous extracellular matrix in the inner layer (intima) of arcuate veins of the kidney. The material resembles mucus and appears pale blue on hematoxylin and eosin staining.		hp.json	Intimal mucoid edema within arcuate veins	http://purl.obolibrary.org/obo/HP_0033880		
UBERON:0014541	biolink:AnatomicalEntity	thoracic division of spinal cord central canal	Part of spinal cord central canal contained in the thoracic spinal cord. It is continuous rostrally with the cervical spinal cord central canal and caudally with the lumbar spinal cord central canal.	FMA:321588|UMLS:C0228637|BIRNLEX:1395	hp.json	thoracic spinal cord central canal	http://purl.obolibrary.org/obo/UBERON_0014541		
UBERON:0014542	biolink:AnatomicalEntity	cervical division of cord spinal central canal	Part of central canal contained within the cervical spinal cord. It is continuous caudally with the thoracic spinal cord central canal and rostrally with the fourth ventricle of the brain via the obex.	UMLS:C0228620|BIRNLEX:1511|FMA:321590	hp.json	cervical spinal cord central canal	http://purl.obolibrary.org/obo/UBERON_0014542		
HP:0033882	biolink:PhenotypicFeature	Arcuate vein intima/medial amyloidosis	Amorphous extracellular substance in the inner or middle layer of the arcuate veins of the kidney. Amyloidosis stains Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy.		hp.json	Amyloidosis within arcuate vein intima/media	http://purl.obolibrary.org/obo/HP_0033882		
HP:0033881	biolink:PhenotypicFeature	Arcuate vein intimal/medial myxomatous degeneration	Accumulation of myxoid material (mucus-like material) within the inner or middle layer of the arcuate vein of the kidney.		hp.json	Myxomatous change within arcuate vein intima/media	http://purl.obolibrary.org/obo/HP_0033881		
UBERON:0014543	biolink:AnatomicalEntity	lumbar division of spinal cord central canal	Part of central canal lying within the lumbar spinal cord. It is continuous rostrally with the central canal of the thoracic spinal cord and caudally with the central canal of the sacral spinal cord.	BIRNLEX:1604|FMA:321589|UMLS:C0228644	hp.json	lumbar spinal cord central canal	http://purl.obolibrary.org/obo/UBERON_0014543		
HP:0031220	biolink:PhenotypicFeature	Increased radioactive iodine uptake	An elevated amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker.		hp.json		http://purl.obolibrary.org/obo/HP_0031220		
HP:0031229	biolink:PhenotypicFeature	Increased incisura length	The length of the incisura from the upper to lower border is greater than that observed in the average population.		hp.json		http://purl.obolibrary.org/obo/HP_0031229		
HP:0033888	biolink:PhenotypicFeature	Abnormal cortical radial artery intima/media morphology	Any structural anomaly of the inner or middle layer of the cortical radial arteries (also known as interlobular arteries) of the kidney.		hp.json	Abnormalities of the interlobular arterial intima/media	http://purl.obolibrary.org/obo/HP_0033888		
HP:0031225	biolink:PhenotypicFeature	Intrapulmonary shunt	Blood flow through a region of the lung in which little or no ventilation takes place, resulting in reduced oxygenation of the blood leaving the lungs.		hp.json	Intrapulmonary shunting	http://purl.obolibrary.org/obo/HP_0031225		
HP:0031226	biolink:PhenotypicFeature	Perinephric fluid collection	An accumulation of fluid in one or more of the perinephric spaces, which consist of the subcapsular, perirenal, anterior and posterior pararenal spaces. This abnormality can be demonstrated by cross-sectional imaging, particularly computed tomography.		hp.json		http://purl.obolibrary.org/obo/HP_0031226		
HP:0033887	biolink:PhenotypicFeature	Cortical radial artery intimal/medial amyloidosis	Amorphous extracellular substance in the glomerular, interstitial or vascular compartments of the interlobular arteries of the kidney. Congo-red positive with typically an apple green birerfingence on polarization microscopy, and 8-12 nm fibrils on electron microscopy		hp.json	Amyloidosis within interlobular arterial intima/media|Interlobular arterial intima/media amyloidosis	http://purl.obolibrary.org/obo/HP_0033887		
UBERON:0014538	biolink:AnatomicalEntity	subdivision of spinal cord central canal	A subdivision of the central canal of the spinal cord along its anterior-posterior axis. This is typically subdivided into cervical, thoracic, lumbar and sacral segments.	BIRNLEX:717	hp.json	regional part of spinal cord central canal	http://purl.obolibrary.org/obo/UBERON_0014538		non_informative
HP:0031227	biolink:PhenotypicFeature	Nasopharyngeal teratoma	A teratoma arising in the nasopharyngeal region.		hp.json		http://purl.obolibrary.org/obo/HP_0031227		
NBO:0002169	biolink:NamedThing	regulation of consumption behavior	"Any process that modulates the frequency, rate or extent of consumption behavior, the specific actions or reactions of an organism in response to external or internal stimuli." [NBOC:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0002169		
HP:0033889	biolink:PhenotypicFeature	Abnormal renal arteriole morphology	Any structural anomaly of the glomerular arterioles. The interlobar arteries of the kidney branch into arcuate arteries, cortical radiate arteries, and then into afferent arterioles. After passing through the renal corpuscle, the capillaries form the efferent arteriole. The afferent and efferent arterioles are difficult to distinguish histologically and are thus both included in this term and its descendents.		hp.json		http://purl.obolibrary.org/obo/HP_0033889		
HP:0031228	biolink:PhenotypicFeature	Abnormal incisura morphology	An abnormal shape of the incisura, defined as the narrowed downward continuation of the conchal space bounded anteriorly by the borders of the tragus, posteriorly by the antitragus, and along its lower lateral margins and inferior boundary by the connection between the first two. The upper boundary is a somewhat arbitrary line crossing from the apices of the antitragus and the tragus.		hp.json		http://purl.obolibrary.org/obo/HP_0031228		
UBERON:0002567	biolink:AnatomicalEntity	basal part of pons	Ventral subdivision of the pons which consists of the massive pontine pertuberance on pontine ventral surface.	FMA:72244|BAMS:Bpons|DHBA:12405|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=616|UMLS:C0228427|BIRNLEX:1043|HBA:9132	hp.json	base of pons|basis pontis|pons proper|ventral portion of pons|basilar part of pons|pars ventralis pontis|pars anterior pontis|basal part of the pons|basal portion of pons|pars basilaris pontis|ventral pons|basilar pons	http://purl.obolibrary.org/obo/UBERON_0002567		pheno_slim
CHEBI:74783	biolink:ChemicalSubstance	astringent	A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions.	Wikipedia:Astringent	hp.json	adstringent|adstringents|astringents	http://purl.obolibrary.org/obo/CHEBI_74783		3_STAR
UBERON:0002561	biolink:AnatomicalEntity	lumen of central nervous system	The cavity that is enclosed by the central nervous system. In vertebrates this is the cavity that includes as parts ventricular cavities and the central canal of the spinal cord that develops from the lumen of the neura tube.	BIRNLEX:1029|FMA:75007	hp.json	cavity of ventricular system of neuraxis|neuraxis lumen|cavity of neuraxis|neuraxis cavity	http://purl.obolibrary.org/obo/UBERON_0002561		
HP:0031232	biolink:PhenotypicFeature	Increased incisura width	Breadth of the incisura from the anterior to posterior border greater than that observed in the average population.		hp.json		http://purl.obolibrary.org/obo/HP_0031232		
HP:0033895	biolink:PhenotypicFeature	Abnormal renal arteriole endothelium morphology	Any structural anomaly of the lining (endothelium) of the arterioles of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033895		
HP:0031233	biolink:PhenotypicFeature	Horizontal inferior border of scapula	A morphological abnormality of the scapula in which there is a flat (horizontal) inferior edge of the scapula. The entire scapula is said to resemble a square, leading to the designation sqaring of the scapula (in Figure 1 of PMID:24706940 the scapulae have a roughly rectangular shape).		hp.json	Squaring of the scapula|Squaring of the inferior scapulae	http://purl.obolibrary.org/obo/HP_0031233		
HP:0033894	biolink:PhenotypicFeature	Renal arteriolar intraluminal thrombi	Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arterioles of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033894		
UBERON:6003005	biolink:AnatomicalEntity	insect adult tagma	Any tagma (UBERON:6000002) that is part of some adult (UBERON:6003004).	FBbt:00003005	hp.json		http://purl.obolibrary.org/obo/UBERON_6003005		
GO:0046534	biolink:BiologicalProcess	positive regulation of photoreceptor cell differentiation	Any process that activates or increases the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.		hp.json	up regulation of photoreceptor cell differentiation|stimulation of photoreceptor cell differentiation|up-regulation of photoreceptor cell differentiation|up-regulation of photoreceptor differentiation|activation of photoreceptor cell differentiation|up regulation of photoreceptor differentiation|positive regulation of photoreceptor differentiation|activation of photoreceptor differentiation|upregulation of photoreceptor cell differentiation|stimulation of photoreceptor differentiation|upregulation of photoreceptor differentiation	http://purl.obolibrary.org/obo/GO_0046534		
HP:0031234	biolink:PhenotypicFeature	Neutrophilic infiltration of the skin	A predominantly neutrophilic infiltrate of the dermis and or epidermis (i.e., a large number of neutrophils inferred to have migrated into the skin).		hp.json		http://purl.obolibrary.org/obo/HP_0031234		
HP:0033897	biolink:PhenotypicFeature	Arcuate artery lumen cholesterol emboli	Needle-like or slit-like clefts within the interior space of arcuate arteries of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.		hp.json	Cholesterol emboli within arcuate arterial lumen	http://purl.obolibrary.org/obo/HP_0033897		
GO:0046533	biolink:BiologicalProcess	negative regulation of photoreceptor cell differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.		hp.json	down regulation of photoreceptor differentiation|inhibition of photoreceptor differentiation|downregulation of photoreceptor cell differentiation|downregulation of photoreceptor differentiation|down regulation of photoreceptor cell differentiation|inhibition of photoreceptor cell differentiation|down-regulation of photoreceptor cell differentiation|down-regulation of photoreceptor differentiation|negative regulation of photoreceptor differentiation	http://purl.obolibrary.org/obo/GO_0046533		
HP:0031235	biolink:PhenotypicFeature	Predominantly epidermal neutrophilic infiltrate	Collection of neutrophils in the epidermis.		hp.json		http://purl.obolibrary.org/obo/HP_0031235		
CHEBI:84118	biolink:ChemicalSubstance	ganglioside GM3	A sialodiaosylceramide that is an alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-N-acylsphingosine in which the acyl group on nitrogen is (15Z)-tetracos-15-enoyl.	PMID:24362891	hp.json	(2S,3R,4E)-3-hydroxy-2-[(15Z)-tetracos-15-enoylamino]octadec-4-en-1-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside|monosialoganglioside GM3|G(M3) ganglioside|monosialodihexosylganglioside|alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-N-(15Z)-tetracos-15-enoylsphingosine|NANA-Gal-Glc-ceramide|alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-N-cis-tetracos-15-enoylsphingosine|GM3	http://purl.obolibrary.org/obo/CHEBI_84118		3_STAR
HP:0033896	biolink:PhenotypicFeature	Abnormal arcuate artery lumen morphology	Abnormal structural characteristics of the interior space (lumen) of the arcuate artery of the kidney.		hp.json	Abnormalities of the arcuate arterial lumen	http://purl.obolibrary.org/obo/HP_0033896		
GO:0046532	biolink:BiologicalProcess	regulation of photoreceptor cell differentiation	Any process that modulates the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.		hp.json	regulation of photoreceptor differentiation	http://purl.obolibrary.org/obo/GO_0046532		
HP:0033891	biolink:PhenotypicFeature	Renal arteriolar lumen cholesterol emboli	Needle-like or slit-like clefts within the interior space of arterioles of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.		hp.json	Cholesterol emboli within the arteriolar lumen	http://purl.obolibrary.org/obo/HP_0033891		
UBERON:0014530	biolink:AnatomicalEntity	white matter lamina of neuraxis		FMA:83856	hp.json	neuraxis lamina|lamina of neuraxis	http://purl.obolibrary.org/obo/UBERON_0014530		
HP:0033890	biolink:PhenotypicFeature	Abnormal renal arteriole lumen morphology	Abnormal structural characteristics of the interior space (lumen) of renal arterioles.		hp.json		http://purl.obolibrary.org/obo/HP_0033890		
GO:0046530	biolink:BiologicalProcess	photoreceptor cell differentiation	The specialization of organization of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light. An example of this process is found in Drosophila melanogaster.		hp.json		http://purl.obolibrary.org/obo/GO_0046530		
UBERON:0014531	biolink:AnatomicalEntity	white matter lamina of diencephalon		FMA:62449	hp.json	lamina of diencephalon|diencephalon lamina	http://purl.obolibrary.org/obo/UBERON_0014531		
HP:0031230	biolink:PhenotypicFeature	Decreased incisura length	The length of the incisura from the upper to lower border is less than that observed in the average population.		hp.json		http://purl.obolibrary.org/obo/HP_0031230		
HP:0033893	biolink:PhenotypicFeature	Renal arteriolar lumen organized thrombi	Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the arterioles of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033893		
HP:0033892	biolink:PhenotypicFeature	Abnormal renal arteriole intima/media morphology	Any structural anomaly located in the inner or middle layer of the arterioles of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033892		
UBERON:0014532	biolink:AnatomicalEntity	white matter lamina of cerebral hemisphere		FMA:67951	hp.json	cerebral hemisphere lamina|lamina of cerebral hemisphere	http://purl.obolibrary.org/obo/UBERON_0014532		
UBERON:6003007	biolink:AnatomicalEntity	insect adult head	Head of the adult organism.	FBbt:00003007	hp.json		http://purl.obolibrary.org/obo/UBERON_6003007		
HP:0031231	biolink:PhenotypicFeature	Narrow incisura width	Width of the incisura from the anterior to posterior border less than that observed in the average population.		hp.json		http://purl.obolibrary.org/obo/HP_0031231		
PATO:0000570	biolink:NamedThing	increased height	A height which is relatively high.		hp.json	tall	http://purl.obolibrary.org/obo/PATO_0000570		value_slim
CHEBI:35106	biolink:ChemicalSubstance	nitrogen hydride			hp.json	nitrogen hydrides	http://purl.obolibrary.org/obo/CHEBI_35106		3_STAR
HP:0033899	biolink:PhenotypicFeature	Arcuate artery lumen organized thrombi	Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the arcuate arteries of the kidney.		hp.json	Organized thrombi within arcuate arterial lumen	http://purl.obolibrary.org/obo/HP_0033899		
HP:0031236	biolink:PhenotypicFeature	Predominantly dermal neutrophilic infiltrate	Collection of neutrophils in the dermis.		hp.json		http://purl.obolibrary.org/obo/HP_0031236		
HP:0031237	biolink:PhenotypicFeature	Internally nucleated skeletal muscle fibers	An abnormally increased proportion of nuclei of sarcomeres with an internal localization. Individual muscle fibers are syncytia, formed by embryonic fusion of many myoblasts or later, myosatellite cells. Each muscle fiber contains many nuclei, peripherally positioned immediately adjacent to the sarcolemmal membrane. In healthy muscle only 3-5% of fibers contain nuclei that are located internally, within the cell, but many disease processes lead to internal nuclei.		hp.json	Internally nucleated skeletal muscle fibres	http://purl.obolibrary.org/obo/HP_0031237		
HP:0033898	biolink:PhenotypicFeature	Arcuate artery intraluminal thrombi	Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arcuate arteries of the kidney.		hp.json	Intraluminal thrombi within arcuate arterial lumen	http://purl.obolibrary.org/obo/HP_0033898		
PATO:0000574	biolink:NamedThing	decreased length	A length quality which is relatively small.		hp.json	stubby|shortened|short	http://purl.obolibrary.org/obo/PATO_0000574		value_slim
HP:0031238	biolink:PhenotypicFeature	Necklace skeletal muscle fibers	A histological alteration of muscle fibers that resembles a necklace (necklace fibers). A substantial proportion of fibers (4-20% in PMID:19084976) show internalized nuclei aligned in a basophilic ring (necklace) at 3 micrometers beneath the sarcolemma. Ultrastructurally, such necklaces consist of myofibrils of smaller diameter, in oblique orientation, surrounded by mitochondria, sarcoplasmic reticulum and glycogen granules.		hp.json	Necklace skeletal muscle fibres	http://purl.obolibrary.org/obo/HP_0031238		
HP:0031239	biolink:PhenotypicFeature	Extrafoveal choroidal neovascularization	A type of choroidal neovascularization in which the nearest edge of the area of neovascularization is located 200 to 1500 micrometers from the center of the fovea.		hp.json		http://purl.obolibrary.org/obo/HP_0031239		
PATO:0000573	biolink:NamedThing	increased length	A length quality which is relatively large.		hp.json	long	http://purl.obolibrary.org/obo/PATO_0000573		value_slim
CHEBI:35107	biolink:ChemicalSubstance	azane	Saturated acyclic nitrogen hydrides having the general formula NnHn+2.		hp.json	azanes	http://purl.obolibrary.org/obo/CHEBI_35107		3_STAR
UBERON:0002553	biolink:AnatomicalEntity	anatomical cavity	Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina.	galen:Cavity|EMAPA:37442|FMA:67552|MA:0002447|NCIT:C34007|BIRNLEX:1011	hp.json	cavity	http://purl.obolibrary.org/obo/UBERON_0002553		upper_level
CHEBI:25754	biolink:ChemicalSubstance	oxo carboxylic acid	Any compound that has an aldehydic or ketonic group as well as a carboxylic acid group in the same molecule.		hp.json	oxo acids|oxo carboxylic acids|oxo carboxylic acids	http://purl.obolibrary.org/obo/CHEBI_25754		3_STAR
UBERON:0002536	biolink:AnatomicalEntity	arthropod sensillum	Sense organ embedded in the integument and consisting of one or a cluster of sensory neurons and associated sensory structures, support cells and glial cells forming a single organised unit with a largely bona-fide boundary.[FBbt].	BTO:0001237|Wikipedia:Sensillum|HAO:0000933|MAT:0000163|FBbt:00007152|EFO:0000939|MIAA:0000163|TGMA:0000540	hp.json	sensillum	http://purl.obolibrary.org/obo/UBERON_0002536		efo_slim|uberon_slim
UBERON:0002539	biolink:AnatomicalEntity	pharyngeal arch	One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches.	SCTID:308766004|AAO:0010359|NCIT:C34249|Wikipedia:Pharyngeal_arch|UMLS:C0080322|MESH:A16.254.160|XAO:0000096|FMA:293015|MAT:0000242|BTO:0001785|EHDAA:571|ZFA:0001306|MIAA:0000242|EMAPA:16117|EFO:0000959|VHOG:0000155|MESH:D001934|TAO:0001306|GAID:1292	hp.json	branchial arch|visceral arch|pharyngeal arches|arcus pharyngei|arcus pharyngei	http://purl.obolibrary.org/obo/UBERON_0002539		vertebrate_core|pheno_slim|efo_slim|uberon_slim
PATO:0000587	biolink:NamedThing	decreased size	A size quality which is relatively low.		hp.json	reduced|underdeveloped|small|hypoplasia|tiny	http://purl.obolibrary.org/obo/PATO_0000587		value_slim
HP:0031243	biolink:PhenotypicFeature	Decreased VLDL cholesterol concentration	A reduction in the amount of very-low-density lipoprotein cholesterol in the blood.		hp.json	Decreased circulating very-low-density lipoprotein levels	http://purl.obolibrary.org/obo/HP_0031243		
PATO:0000586	biolink:NamedThing	increased size	A size quality which is relatively high.		hp.json	great|large|expanded|enlarged|big	http://purl.obolibrary.org/obo/PATO_0000586		value_slim
HP:0031244	biolink:PhenotypicFeature	Swollen lip	Enlargement of the lip typically due to fluid buildup or inflammation.		hp.json	Edematous lip|Swelling of the lip	http://purl.obolibrary.org/obo/HP_0031244		
GO:0046545	biolink:BiologicalProcess	development of primary female sexual characteristics	The process whose specific outcome is the progression of the primary female sexual characteristics over time, from their formation to the mature structure. The primary female sexual characteristics are the ovaries, and they develop in response to sex hormone secretion.		hp.json		http://purl.obolibrary.org/obo/GO_0046545		
HP:0031245	biolink:PhenotypicFeature	Productive cough	A cough that produces phlegm or mucus.		hp.json	Wet cough|Cough with mucus production	http://purl.obolibrary.org/obo/HP_0031245		
GO:0046544	biolink:BiologicalProcess	development of secondary male sexual characteristics	The process whose specific outcome is the progression of the secondary male sexual characteristics over time, from their formation to the mature structures. In male humans, these include growth of axillary, chest, and pubic hair, voice changes, and testicular/penile enlargement. Development occurs in response to sex hormone secretion.		hp.json		http://purl.obolibrary.org/obo/GO_0046544		
HP:0031246	biolink:PhenotypicFeature	Nonproductive cough	A cough that does not produce phlegm or mucus.		hp.json	Dry coughing|Dry cough	http://purl.obolibrary.org/obo/HP_0031246		
PATO:0000588	biolink:NamedThing	vestigial			hp.json		http://purl.obolibrary.org/obo/PATO_0000588		
CHEBI:60164	biolink:ChemicalSubstance	ionic polymer	An ionic polymer is a polymer, composed of ionic macromolecules.		hp.json	polyionic polymer	http://purl.obolibrary.org/obo/CHEBI_60164		3_STAR
GO:0046543	biolink:BiologicalProcess	development of secondary female sexual characteristics	The process whose specific outcome is the progression of the secondary female sexual characteristics over time, from their formation to the mature structures. In female humans, these include growth of axillary and pubic hair, breast development and menstrual periods. Their development occurs in response to sex hormone secretion.		hp.json		http://purl.obolibrary.org/obo/GO_0046543		
HP:0031240	biolink:PhenotypicFeature	Juxtafoveal choroidal neovascularization	A type of choroidal neovascularization in which the nearest edge of the area of neovascularization is located 1 to 199 micrometers from the center of the fovea.		hp.json		http://purl.obolibrary.org/obo/HP_0031240		
HP:0031241	biolink:PhenotypicFeature	Subfoveal choroidal neovascularization	A type of choroidal neovascularization in which the area of neovascularization overlaps with the center of the fovea.		hp.json		http://purl.obolibrary.org/obo/HP_0031241		
GO:0046541	biolink:BiologicalProcess	saliva secretion	The regulated release of saliva from the salivary glands. In man, the saliva is a turbid and slightly viscous fluid, generally of an alkaline reaction, and is secreted by the parotid, submaxillary, and sublingual glands. In the mouth the saliva is mixed with the secretion from the buccal glands. In man and many animals, saliva is an important digestive fluid on account of the presence of the peculiar enzyme, ptyalin.	Wikipedia:Salivation	hp.json	salivation	http://purl.obolibrary.org/obo/GO_0046541		
HP:0031242	biolink:PhenotypicFeature	Decreased circulating chylomicron concentration	Reduced plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins.		hp.json	Decreased circulating chylomicron levels|Hypochylomicronemia	http://purl.obolibrary.org/obo/HP_0031242		
CHEBI:84125	biolink:ChemicalSubstance	globoside Gb4	A glycotetraosylceramide in which a linear beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->-4)-beta-D-Gal-(1->4)-beta-D-Glc tetrasaccharide unit is linked glycosidically to a (3R,4E)-3-hydroxy-2-(pentacosanoylamino)octadec-4-en-1-yl ceramide group.	PMID:24362891	hp.json	GalbetaNAcbeta3Galalpha4Galbeta4GlcbetaCer|(15Z)-N-[(2S,3R,4E)-1-{[N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]tetracos-15-enamide|(15Z)-N-[(2S,3R,4E)-1-{[2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->3)-alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]tetracos-15-enamide|globoside Gb4Cer(d18:1(4E)/24:1(15Z))	http://purl.obolibrary.org/obo/CHEBI_84125		3_STAR
HP:0031247	biolink:PhenotypicFeature	Whooping cough	A type of cough characterized by a burst of numerous and rapid coughs followed by a long inhaling effort that is accompanied by a high-pitched whooping sound produced by the inhalation of air.		hp.json		http://purl.obolibrary.org/obo/HP_0031247		
HP:0031248	biolink:PhenotypicFeature	Palmar pruritus	Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching over the palm(s) of the hand.		hp.json	Itchy palm	http://purl.obolibrary.org/obo/HP_0031248		
PATO:0000585	biolink:NamedThing	hypotrophic	A decreased size quality inhering in a bearer by virtue of the bearer's exhibiting reduced size of a cell or constituent group of cells (for example, organ).		hp.json	shrunken	http://purl.obolibrary.org/obo/PATO_0000585		value_slim|mpath_slim
CHEBI:37734	biolink:ChemicalSubstance	phosphoric ester			hp.json		http://purl.obolibrary.org/obo/CHEBI_37734		1_STAR
GO:0046549	biolink:BiologicalProcess	retinal cone cell development	Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision.		hp.json		http://purl.obolibrary.org/obo/GO_0046549		
HP:0031249	biolink:PhenotypicFeature	Parageusia	A distortion of the sense of taste, often characterized by the sensation of a metallic taste.		hp.json	Dysgeusia|Altered sense of taste|Metallic taste in mouth|Metallic taste	http://purl.obolibrary.org/obo/HP_0031249		
PATO:0000584	biolink:NamedThing	hypertrophic	An increased size quality inhering in a bearer by virtue of the bearer's exhibiting enlargement of a cell or constituent group of cells (for example, organ).		hp.json	hypertrophy	http://purl.obolibrary.org/obo/PATO_0000584		value_slim|mpath_slim
GO:0046548	biolink:BiologicalProcess	retinal rod cell development	Development of a rod cell, one of the sensory cells in the eye that reacts to the presence of light. Rod cells contain the photopigment rhodopsin or porphyropsin and are responsible for vision in dim light.		hp.json		http://purl.obolibrary.org/obo/GO_0046548		
UBERON:0002544	biolink:AnatomicalEntity	digit	A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans).	AAO:0011126|NCIT:C40186|VHOG:0000944|OpenCyc:Mx4rvzLD_ZwpEbGdrcN5Y29ycA|XAO:0003032|MA:0000690|MAT:0000285|EFO:0000881|MIAA:0000285|galen:Digit|EMAPA:32725|FMA:85518|UMLS:C0582802	hp.json	limb digit|digit (phalangeal portion) plus soft tissue|acropodial unit	http://purl.obolibrary.org/obo/UBERON_0002544		pheno_slim|efo_slim|uberon_slim
UBERON:0002546	biolink:AnatomicalEntity	cranial placode	Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic.	AAO:0010466|MIAA:0000369|XAO:0000305|EFO:0001650|FMA:293966|MAT:0000369	hp.json	placode|placode|cranial placodes|ectodermal placode|ectodermal cranial placode|ectodermal placode	http://purl.obolibrary.org/obo/UBERON_0002546		efo_slim
UBERON:0002529	biolink:AnatomicalEntity	limb segment	A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles.	FMA:241863|NCIT:C38630|UMLS:C1268195|MA:0002889	hp.json	segment of limb|limb region|region of limb|extremity part|subdivision of limb|free limb segment	http://purl.obolibrary.org/obo/UBERON_0002529		
UBERON:0002528	biolink:AnatomicalEntity	sacral lymph node	A lymph node located in the sacral region.	NCIT:C77647|MA:0002883|FMA:16655|UMLS:C0229827	hp.json	sacral node	http://purl.obolibrary.org/obo/UBERON_0002528		
UBERON:0002527	biolink:AnatomicalEntity	pancreatic lymph node	A lymph node that is part of a pancreas [Automatically generated definition].	NCIT:C77642|MA:0002881|FMA:16626|UMLS:C0229783	hp.json	pyloric lymph node|aJCC level 19 node|pancreas lymph node|lymph node of pancreas|pancreatic node	http://purl.obolibrary.org/obo/UBERON_0002527		
HP:0031254	biolink:PhenotypicFeature	Thalamic arteriovenous malformation	An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the thalamus.		hp.json		http://purl.obolibrary.org/obo/HP_0031254		
HP:0031255	biolink:PhenotypicFeature	Hypothalamic arteriovenous malformation	An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the hypothalamus.		hp.json		http://purl.obolibrary.org/obo/HP_0031255		
HP:0031256	biolink:PhenotypicFeature	Optic nerve arteriovenous malformation	An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the optic nerve.		hp.json		http://purl.obolibrary.org/obo/HP_0031256		
PATO:0000599	biolink:NamedThing	decreased width	A width which is relatively small.		hp.json	narrow	http://purl.obolibrary.org/obo/PATO_0000599		value_slim
HP:0031257	biolink:PhenotypicFeature	Arteriovenous malformation of the maxilla	An arteriovenous malformation is a disruption of the normal vascular pattern in which arteries or arterioles connect directly to the venous collection system, bypassing any capillary bed. This term refers to an arteriovenous malformation located in the maxilla.		hp.json		http://purl.obolibrary.org/obo/HP_0031257		
HP:0031250	biolink:PhenotypicFeature	Lip fissure	A severe crack in a lip. A lip fissure may be painful, may bleed and often is a recurring manifestation.		hp.json		http://purl.obolibrary.org/obo/HP_0031250		
HP:0031251	biolink:PhenotypicFeature	Abnormal subclavian artery morphology	Any anomaly of a subclavian artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031251		
HP:0031252	biolink:PhenotypicFeature	Dilated left subclavian artery	Abnormally increased caliber of the left subclavian artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031252		
HP:0031253	biolink:PhenotypicFeature	Anomalous origin of left subclavian artery	Origin of the left subclavian artery from an anomalous anatomical location.		hp.json		http://purl.obolibrary.org/obo/HP_0031253		
UBERON:0014508	biolink:AnatomicalEntity	distal interphalangeal joint of manual digit 3	A distal inter-phalangeal joint that is part of the 3rd manual digit.	FMA:35337	hp.json	distal interphalangeal joint of manual digit III|equine second interphalangeal joint of forelimb digit III|distal interphalangeal joint of middle finger|equine distal interphalangeal joint of forelimb|forelimb coffin joint	http://purl.obolibrary.org/obo/UBERON_0014508		pheno_slim
PATO:0000592	biolink:NamedThing	decreased thickness	A thickness which is relatively low.		hp.json	thin|slender|low thickness	http://purl.obolibrary.org/obo/PATO_0000592		mpath_slim|value_slim
PATO:0000591	biolink:NamedThing	increased thickness	A thickness which is relatively high.		hp.json	high thickness|thickened|stout|thick	http://purl.obolibrary.org/obo/PATO_0000591		mpath_slim|value_slim
UBERON:0014504	biolink:AnatomicalEntity	proximal phalanx of digit 4	A proximal phalanx that is part of a autopod digit 4 [Automatically generated definition].		hp.json	digit IV P1|4th digit proximal phalanx|autopod digit 4 proximal phalanx|fourth digit proximal phalanx|proximal phalanx of fourth digit of autopod|proximal phalanx of 4th digit|4th digit of autopod proximal phalanx|proximal phalanx of digit IV|proximal phalanx of ring digit|digit IV-1|fourth proximal phalanx of autopod|proximal phalanx of 4th digit of autopod|proximal phalanx of fourth digit	http://purl.obolibrary.org/obo/UBERON_0014504		
HP:0031258	biolink:PhenotypicFeature	Delirium	A state of sudden and severe confusion.		hp.json		http://purl.obolibrary.org/obo/HP_0031258		
UBERON:0014505	biolink:AnatomicalEntity	proximal phalanx of digit 5	A proximal phalanx that is part of a autopod digit 5 [Automatically generated definition].		hp.json	fifth digit proximal phalanx|digit V P1|proximal phalanx of little digit|5th digit proximal phalanx|5th digit of autopod proximal phalanx|proximal phalanx of 5th digit|autopod digit 5 proximal phalanx|digit V-1|proximal phalanx of fifth digit|proximal phalanx of digit V|proximal phalanx of fifth digit of autopod|fifth proximal phalanx of autopod|proximal phalanx of 5th digit of autopod	http://purl.obolibrary.org/obo/UBERON_0014505		
HP:0031259	biolink:PhenotypicFeature	Oophoritis	An inflammation of the ovary or ovaries.		hp.json	Inflammed ovary	http://purl.obolibrary.org/obo/HP_0031259		
UBERON:0014506	biolink:AnatomicalEntity	distal interphalangeal joint of digit 3	A distal inter-phalangeal joint that is part of the 3rd digit.	NCIT:C102292	hp.json	equine distal interphalangeal joint|distal interphalangeal joint 3|distal interphalangeal joint of digit III|equine second interphalangeal joint of limb digit III|coffin joint	http://purl.obolibrary.org/obo/UBERON_0014506		
PATO:0000596	biolink:NamedThing	decreased volume	A volume which is relatively low.		hp.json	low volume|small volume	http://purl.obolibrary.org/obo/PATO_0000596		mpath_slim|value_slim
PATO:0000595	biolink:NamedThing	increased volume	A volume which is relatively high.		hp.json	high volume|large volume	http://purl.obolibrary.org/obo/PATO_0000595		mpath_slim|value_slim
UBERON:0014507	biolink:AnatomicalEntity	distal interphalangeal joint of pedal digit 3	A distal inter-phalangeal joint that is part of the 3rd pedal digit.	FMA:35375	hp.json	equine distal interphalangeal joint of hindlimb|distal interphalangeal joint of third toe|hindlimb coffin joint|distal interphalangeal joint of third digit of foot|distal interphalangeal joint of pedal digit III	http://purl.obolibrary.org/obo/UBERON_0014507		pheno_slim
UBERON:0002533	biolink:AnatomicalEntity	post-anal tail bud	The rapidly proliferating mass of cells at the caudal extremity of the embryo; remnant of the primitive node.	MIAA:0000070|ZFA:0000077|AAO:0011104|EHDAA:1595|TAO:0000077|EMAPA:16580|BTO:0001445|XAO:0000107|VHOG:0000201|MAT:0000070|EHDAA2:0001976|EFO:0002748	hp.json	tail bud mesenchyme|tail bud|end bud|tailbud	http://purl.obolibrary.org/obo/UBERON_0002533		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0002532	biolink:AnatomicalEntity	epiblast (generic)	In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA].	MAT:0000067|MIAA:0000067|VHOG:0000243|BTO:0004593|Wikipedia:Epiblast|FMA:296704	hp.json	epiblastus|epiblast|primitive ectoderm|blastocyst|ectoblast|epiblastus	http://purl.obolibrary.org/obo/UBERON_0002532		grouping_class|early_development|uberon_slim|vertebrate_core
UBERON:0002530	biolink:AnatomicalEntity	gland	An organ that functions as a secretory or excretory organ.	EFO:0000797|EHDAA:6522|BTO:0000522|AAO:0000212|EHDAA:4475|UMLS:C1285092|WikipediaCategory:Glands|MAT:0000021|FBbt:00100317|EHDAA:2161|galen:Gland|SCTID:134358001|MIAA:0000021|EHDAA2:0003096|NCIT:C13319|EMAPA:18425|FMA:86294|OpenCyc:Mx4rwP3vyJwpEbGdrcN5Y29ycA|Wikipedia:Gland|AEO:0000096|HAO:0000375|FMA:7146|MA:0003038	hp.json	Druese|glandula|glandular organ|glandular organ|glandula|glandula	http://purl.obolibrary.org/obo/UBERON_0002530		pheno_slim|efo_slim|uberon_slim
HP:0033840	biolink:PhenotypicFeature	Postmenopausal bleeding	Uterine bleeding that occurs after at least one year of amenorrhea in a woman who is not receiving hormone therapy.		hp.json		http://purl.obolibrary.org/obo/HP_0033840		
HP:0033842	biolink:PhenotypicFeature	Early satiety	The condition of being unable to eat a full meal because of a feeling of fullness (satiety), or or feeling very full after eating only a small amount of food.		hp.json	Not able to finish a normal-sized meal|Feeling full quickly when eating	http://purl.obolibrary.org/obo/HP_0033842		
HP:0033841	biolink:PhenotypicFeature	Ocular pruritus	Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased sensation of itching in the region of the eye.		hp.json	Itchy eyes|Ocular itch	http://purl.obolibrary.org/obo/HP_0033841		
HP:0033848	biolink:PhenotypicFeature	Receptive aphasia	A type of aphasia that is characterized by impaired language comprehension.		hp.json	Wernicke aphasia|Fluent aphasia	http://purl.obolibrary.org/obo/HP_0033848		
HP:0033847	biolink:PhenotypicFeature	Phantageusia	A form of altered taste sensation in which the affected person perceives a taste, usually an unpleasant one, in the absence of a corresponding stimulus in the environment.		hp.json	Phantom taste	http://purl.obolibrary.org/obo/HP_0033847		
HP:0033849	biolink:PhenotypicFeature	Bilingual aphasia	The term bilingual aphasia is used to refer to aphasia in persons who speak two or more languages. When a multilingual speaker has aphasia following a stroke, the languages spoken premorbidly may show comparable or differential patterns of impairment. Differential patterns may manifest as greater impairment in one language compared to another, or as differences in the characteristics of aphasia. Clinical reports of bilingual aphasia show dissociations in the processing of the language learned first (L1) and and second (L2), with one language more impaired than the other. Other cases show a pattern of differential recovery where L2 is recovered only after L1. Another pattern is alternating antagonism; i.e., patients access one language in spontaneous speech and inhibit the other language for alternating periods. This term should be used for a type of aphasia in a person who speaks multiple languages in which the impairment is different for different languages.		hp.json		http://purl.obolibrary.org/obo/HP_0033849		
HP:0033844	biolink:PhenotypicFeature	Tachyphrenia	The sensation that thoughts are moving too quickly.		hp.json	Racing thoughts	http://purl.obolibrary.org/obo/HP_0033844		
HP:0033843	biolink:PhenotypicFeature	Postprandial fullness	Feeling excessively full after meals.		hp.json		http://purl.obolibrary.org/obo/HP_0033843		
HP:0006216	biolink:PhenotypicFeature	Single interphalangeal crease of fifth finger	Presence of only one (instead of two, as normal) interphalangeal crease of the fifth finger.	UMLS:C1850336	hp.json	Fifth finger single interphalangeal crease	http://purl.obolibrary.org/obo/HP_0006216		
HP:0033846	biolink:PhenotypicFeature	Spinal hypomyelination	Reduced amount of myelin in the spinal cord resulting from defective myelinogenesis.		hp.json		http://purl.obolibrary.org/obo/HP_0033846		
HP:0033845	biolink:PhenotypicFeature	Sense of impending doom	A feeling that something life-threatening or tragic is about to occur.		hp.json	Sense of doom	http://purl.obolibrary.org/obo/HP_0033845		
HP:0006217	biolink:PhenotypicFeature	Limited mobility of proximal interphalangeal joint		UMLS:C1857288	hp.json	Limited mobility of innermost hinge joint	http://purl.obolibrary.org/obo/HP_0006217		
HP:0008873	biolink:PhenotypicFeature	Disproportionate short-limb short stature	A type of disproportionate short stature characterized by a short limbs but an average-sized trunk.	UMLS:C1849937	hp.json	Dwarfism, short-limbed|Micromelic dwarfism|Brachymelic dwarfism|Short stature, disproportionate short-limb|Short-limbed dwarfism|Disproportionate short limb dwarfism|Short limb dwarfism, disproportionate|Short-limb dwarfism|Short stature, disproportionate short limb|Short limb dwarfism	http://purl.obolibrary.org/obo/HP_0008873		hposlim_core
HP:0006210	biolink:PhenotypicFeature	Postaxial oligodactyly		UMLS:C1867927	hp.json		http://purl.obolibrary.org/obo/HP_0006210		
HP:0008872	biolink:PhenotypicFeature	Feeding difficulties in infancy	Impaired feeding performance of an infant as manifested by difficulties such as weak and ineffective sucking, brief bursts of sucking, and falling asleep during sucking. There may be difficulties with chewing or maintaining attention.	UMLS:C2674608	hp.json		http://purl.obolibrary.org/obo/HP_0008872		
HP:0006213	biolink:PhenotypicFeature	Thin proximal phalanges with broad epiphyses of the hand		UMLS:C1862156|UMLS:C4025079	hp.json	Thin proximal phalanges with broad epiphyses|Thin innermost bone with broad end part of the hand bone	http://purl.obolibrary.org/obo/HP_0006213		
HP:0033851	biolink:PhenotypicFeature	Oculomotor synkinesis	Elevation of the upper eyelid on attempted downward gaze or adduction, adduction of the eye on attempted upward or downward gaze, and constriction of the pupil on attempted adduction.		hp.json		http://purl.obolibrary.org/obo/HP_0033851		
HP:0033850	biolink:PhenotypicFeature	Coldness	Relative coldness of a body part to palpitation, often acccompanied by feelings of coldness.		hp.json	Cold skin temperature|Coolness to palpation|Cool skin temperature|Cool skin	http://purl.obolibrary.org/obo/HP_0033850		
HP:0033853	biolink:PhenotypicFeature	Abnormal arcuate vein morphology	Any structural anomaly of the arcuate vein. The arcuate veins cross traverse along the corticomedullary junction (at the border of the kideny cortex and medulla).		hp.json		http://purl.obolibrary.org/obo/HP_0033853		
HP:0033852	biolink:PhenotypicFeature	Abnormal intrarenal vein morphology	Abnormal structure of a vein located inside the kidney parenchyma.		hp.json		http://purl.obolibrary.org/obo/HP_0033852		
HP:0033859	biolink:PhenotypicFeature	Abnormal peritubular capillary morphology	Anomalous structure of the capillaries that are derived from the efferent arteriole, forming a capillary network that surrounds the distal portions of the nephron tubule,		hp.json		http://purl.obolibrary.org/obo/HP_0033859		
HP:0033858	biolink:PhenotypicFeature	Organized thrombi within interlobular vein lumen	Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the interlobular veins of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033858		
HP:0033855	biolink:PhenotypicFeature	Abnormal interlobular vein lumen morphology	Any structural anomaly located in the the inside space of the interlobular veins of the kidney.		hp.json	Abnormal morphology of the interlobular vein lumen	http://purl.obolibrary.org/obo/HP_0033855		
HP:0008887	biolink:PhenotypicFeature	Adipose tissue loss	A loss of adipose tissue.	UMLS:C4024615	hp.json	Loss of fat tissue	http://purl.obolibrary.org/obo/HP_0008887		
CHEBI:59174	biolink:ChemicalSubstance	hapten	Any substance capable of eliciting an immune response only when attached to a large carrier such as a protein. Examples include dinitrophenols; oligosaccharides; peptides; and heavy metals.	PMID:291959|PMID:17986299|PMID:19101624|PMID:17875790|PMID:3782019	hp.json	haptens	http://purl.obolibrary.org/obo/CHEBI_59174		3_STAR
HP:0006226	biolink:PhenotypicFeature	Osteoarthritis of the first carpometacarpal joint		UMLS:C0409956|SNOMEDCT_US:37895003	hp.json		http://purl.obolibrary.org/obo/HP_0006226		
HP:0033854	biolink:PhenotypicFeature	Abnormal interlobular vein morphology	Any structural anomaly of the interlobular veins of the kidney. An interlobular vein is surrounded by the renal cortex and located between renal lobules (consisting of the nephrons surrounding a single medullary ray and draining into a single collecting duct).		hp.json		http://purl.obolibrary.org/obo/HP_0033854		
HP:0033857	biolink:PhenotypicFeature	Intraluminal thrombi within interlobular veins	Mixture of fibrin, red blood cells, platelets partly or completely occluding vascular lumen of the interlobular veins of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033857		
HP:0033856	biolink:PhenotypicFeature	Cholesterol emboli within interlobular vein lumen	Needle-like or slit-like clefts within the interior space of interlobular veins. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.		hp.json		http://purl.obolibrary.org/obo/HP_0033856		
HP:0006228	biolink:PhenotypicFeature	Valgus hand deformity		UMLS:C1860179	hp.json		http://purl.obolibrary.org/obo/HP_0006228		
HP:0008883	biolink:PhenotypicFeature	Mild intrauterine growth retardation	Intrauterine growth retardation that is at least 2 standard deviations (SD) below average, but not as low as 3 SD, corrected for sex and gestational age.	UMLS:C1840006	hp.json	Mild prenatal growth deficiency	http://purl.obolibrary.org/obo/HP_0008883		
HP:0006224	biolink:PhenotypicFeature	Tapering pointed ends of distal finger phalanges	A reduction in diameter of the distal phalanx of finger towards the distal end such that the tip of the phalanx comes to a point (this feature can be observed on radiograms).	UMLS:C4025078	hp.json		http://purl.obolibrary.org/obo/HP_0006224		
HP:0033862	biolink:PhenotypicFeature	Cortical peritubular capillaritis	Inflammation of the peritubular capillaries in the cortex of the kidney characterized by Inflammatory cells in over 10 percent of the interstitial capillaries in the cortex with at least some capillaries having three or more luminal cells.		hp.json		http://purl.obolibrary.org/obo/HP_0033862		
HP:0033861	biolink:PhenotypicFeature	Multilamellation of cortical peritubular capillary basement membranes	Duplicated basement membranes of the peritubular capillaries located in the cortex of the kidney and arranged in multiple concentric layers.		hp.json	Multilamellation of basement membranes within cortical peritubular capillaries	http://purl.obolibrary.org/obo/HP_0033861		
HP:0031200	biolink:PhenotypicFeature	Hyaline casts	A type of acellular urinary cast that are composed only of Tamm-Horsfall glycoprotein, a fact which explains their low refractive index. Hyaline casts may display a spectrum of morphologies, which includes fluffy, compact, convoluted or wrinkled casts. Hyaline casts have a smooth texture and usually have parallel sides with clear margins and blunted ends.		hp.json		http://purl.obolibrary.org/obo/HP_0031200		
HP:0033864	biolink:PhenotypicFeature	Abnormal medullary peritubular capillary morphology	Anomalous structure of the peritubular capillaries located in the medulla of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033864		
HP:0031201	biolink:PhenotypicFeature	Granular casts	A type of acelluar casts that have a surface composed of granules, which can vary in size. The granules can be rather heterogeneous, ranging from fine (finely granular cast) up to coarse (coarsely granular cast), dark, clear, and pigmented.		hp.json		http://purl.obolibrary.org/obo/HP_0031201		
HP:0033863	biolink:PhenotypicFeature	Abnormal cortical peritubular capillary lumen morphology	Abnormal structural characteristics of the interior space of the peritubular capillary in the cortex of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033863		
HP:0031202	biolink:PhenotypicFeature	Waxy casts	A type of acellular urinary casts that display a melted wax (waxy) appearance, which gives them a high refractive index. They are frequently dark, with blunt extremities, indented and cracked edges and a large size, which is often several times that of other types of casts.		hp.json		http://purl.obolibrary.org/obo/HP_0031202		
PATO:0000547	biolink:NamedThing	photosensitive	A photosensitivity quality inhering in a bearer by virtue of the bearer's exhibiting photosensitivity.		hp.json		http://purl.obolibrary.org/obo/PATO_0000547		disposition_slim|value_slim
HP:0033860	biolink:PhenotypicFeature	Abnormal cortical peritubular capillary morphology	Anomalous structure of the peritubular capillaries located in the cortex of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033860		
HP:0031207	biolink:PhenotypicFeature	Hepatic hemangioma	A congenital vascular malformation in the liver composed of masses of blood vessels that are atypical or irregular in arrangement and size.		hp.json	Liver hemangioma|Hemangioma of the liver	http://purl.obolibrary.org/obo/HP_0031207		
HP:0033869	biolink:PhenotypicFeature	Medullary peritubular capillary lumen cholesterol emboli	Needle-like or slit-like clefts within the interior space of peritubular capillaries located in the medulla of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.		hp.json	Cholesterol emboli within the medullary peritubular capillary lumen	http://purl.obolibrary.org/obo/HP_0033869		
HP:0031208	biolink:PhenotypicFeature	Increased pituitary glycoprotein hormone alpha subunit level	An increased concentration of circulating alpha polypeptide of glycoprotein hormones (NCBI Gene 1081). This alpha subunit is common to luteinizing hormone (LH) , follicle stimulating hormone (FSH) , thyroid stimulating hormone (TSH) and human chorionic gonadotropin (hCG), which are glycoprotein hormones composed of an identical alpha subunit together with a beta subunit that confers biological specificity. The alpha subunit is used as a marker for tumors that produce these hormones.		hp.json	Increased pituitary glycoprotein polypeptide alpha subunit level|Increased pituitary glycoprotein alpha subunit level	http://purl.obolibrary.org/obo/HP_0031208		
HP:0031209	biolink:PhenotypicFeature	Decreased circulating lipoprotein lipase concentration	Reduction in the level of lipoprotein lipase in the blood.		hp.json	Decreased lipoprotein lipase level	http://purl.obolibrary.org/obo/HP_0031209		
HP:0031203	biolink:PhenotypicFeature	Fatty casts	A type of acellular urinary casts that contain lipid droplets, oval fat bodies or cholesterol crystals, and are often associated with the free forms of these elements. Their identification may require the use of polarised light microscopy, under which fatty particles embedded into the cast matrix appear as Maltese crosses.		hp.json		http://purl.obolibrary.org/obo/HP_0031203		
HP:0008855	biolink:PhenotypicFeature	Moderate postnatal growth retardation	A moderate degree of slow or limited growth after birth, being between three and four standard deviations below age- and sex-related norms.	UMLS:C4024616	hp.json	Moderate growth delay in children	http://purl.obolibrary.org/obo/HP_0008855		
HP:0033866	biolink:PhenotypicFeature	Medullary peritubular capillary erythrocyte congestion	Substantially increased numbers of red blood cells within capillaries surrounding tubules in the medulla of the kidney. This feature is assessed in histological images as the presence of numerous erythrocytes in a segment of the capillary such that the vessel appears to be congested (not open).		hp.json		http://purl.obolibrary.org/obo/HP_0033866		
HP:0033865	biolink:PhenotypicFeature	Medullary peritubular capillaritis	Inflammation of the peritubular capillaries in the medulla of the kidney characterized by Inflammatory cells in over 10 percent of the interstitial capillaries in the cortex with at least some capillaries having three or more luminal cells.		hp.json		http://purl.obolibrary.org/obo/HP_0033865		
CHEBI:59163	biolink:ChemicalSubstance	biomarker	A substance used as an indicator  of a biological state.		hp.json	biological marker	http://purl.obolibrary.org/obo/CHEBI_59163		3_STAR
HP:0031204	biolink:PhenotypicFeature	Bacterial cell casts	A type of urinary cast that contain bacteria. Bacterial casts can be difficult to identify and can be distinguished from other types of casts using phase contrast microscopy. Bacterial casts are diagnostic of acute pyelonephritis or intrinsic renal infection.		hp.json		http://purl.obolibrary.org/obo/HP_0031204		
HP:0033868	biolink:PhenotypicFeature	Abnormal medullary peritubular capillary lumen morphology	Abnormal structural characteristics of the interior space of the peritubular capillary in the medulla of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033868		
HP:0008857	biolink:PhenotypicFeature	Neonatal short-trunk short stature	A type of disproportionate short stature characterized by a short trunk but a average-sized limbs with congenital onset recognizable at birth.	UMLS:C3149908	hp.json	Short-trunk dwarfism identifiable at birth	http://purl.obolibrary.org/obo/HP_0008857		
HP:0031205	biolink:PhenotypicFeature	Reduced lysosomal acid lipase activity	Reduction in the activity of lysosomal acid lipase (LAL) in the blood. Lysosomal lipase activity is measured. LAL hydrolyzes cholesteryl esters derived from cell internalization of plasma lipoproteins.		hp.json	Reduced leukocyte acid lipase activity	http://purl.obolibrary.org/obo/HP_0031205		
HP:0033867	biolink:PhenotypicFeature	Multilamellation of medullary peritubular capillary basement membranes	Duplicated basement membranes of the peritubular capillaries located in the medulla of the kidney and arranged in multiple concentric layers.		hp.json	Multilamellation of basement membranes within medullary peritubular capillaries	http://purl.obolibrary.org/obo/HP_0033867		
HP:0031206	biolink:PhenotypicFeature	Striatal T2 hyperintensity	Abnormally bright T2 signal from the striatum on brain magnetic resonance imaging.		hp.json		http://purl.obolibrary.org/obo/HP_0031206		
HP:0008850	biolink:PhenotypicFeature	Severe postnatal growth retardation	Severely slow or limited growth after birth, being four standard deviations or more below age- and sex-related norms.	UMLS:C1857641	hp.json	Severe growth delay in children|Severe postnatal growth failure|Marked growth retardation|Severe postnatal growth deficiency	http://purl.obolibrary.org/obo/HP_0008850		
CHEBI:35195	biolink:ChemicalSubstance	surfactant	A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces.		hp.json	surfactants|surface active agent|surfactant	http://purl.obolibrary.org/obo/CHEBI_35195		3_STAR
HP:0033873	biolink:PhenotypicFeature	Cortical peritubular capillary intraluminal thrombi	Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the peritubular capillaries located in the cortex of the kidney.		hp.json	Intraluminal thrombi within cortical peritubular capillaries	http://purl.obolibrary.org/obo/HP_0033873		
HP:0031210	biolink:PhenotypicFeature	Abnormal circulating hyaluronic acid concentration	A deviation from the normal concentration of hyaluronic acid in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031210		
HP:0031211	biolink:PhenotypicFeature	Elevated cholesterol ester level	An elevated concentration of circulating cholesterol esters, which are fatty acid esters of cholesterol and make up about two-thirds of total plasma cholesterol.		hp.json	Increased cholesteryl esters|Elevated cholesteryl ester level|Increased cholesterol esters	http://purl.obolibrary.org/obo/HP_0031211		
HP:0033872	biolink:PhenotypicFeature	Cortical peritubular capillary lumen cholesterol emboli	Needle-like or slit-like clefts within the interior space of peritubular capillaries located in the cortex of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.		hp.json		http://purl.obolibrary.org/obo/HP_0033872		
HP:0031212	biolink:PhenotypicFeature	Abnormal circulating progesterone level			hp.json		http://purl.obolibrary.org/obo/HP_0031212		
HP:0033875	biolink:PhenotypicFeature	Abnormal arcuate vein lumen morphology	Abnormal structural characteristics of the interior space (lumen) of the arcuate vein of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033875		
HP:0031213	biolink:PhenotypicFeature	Elevated circulating 17-hydroxyprogesterone	An increased level of 17-hydroxyprogesterone in the blood. 17-hydroxyprogesterone is an intermediate steroid in the adrenal biosynthetic pathway from cholesterol to cortisol and is the substrate for steroid 21-hydroxylase.		hp.json	Elevated circulating 17-OHP	http://purl.obolibrary.org/obo/HP_0031213		
HP:0033874	biolink:PhenotypicFeature	Cortical peritubular capillary lumen organized thrombi	Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the peritubular capillaries of the cortex of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033874		
HGNC:7045	biolink:Gene	MGAT2 (human)	A protein coding gene MGAT2 in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7045		
HP:0033871	biolink:PhenotypicFeature	Medullary peritubular capillary lumen organized thrombi	Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the peritubular capillaries of the medulla of the kidney.		hp.json	Organized thrombi within the medullary peritubular capillary lumen	http://purl.obolibrary.org/obo/HP_0033871		
HP:0033870	biolink:PhenotypicFeature	Medullary peritubular capillary intraluminal thrombi	Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the peritubular capillaries located in the medulla of the kidney.		hp.json	Intraluminal thrombi within medullary peritubular capillaries	http://purl.obolibrary.org/obo/HP_0033870		
GO:0010594	biolink:BiologicalProcess	regulation of endothelial cell migration	Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.		hp.json		http://purl.obolibrary.org/obo/GO_0010594		
HP:0031218	biolink:PhenotypicFeature	Inappropriate antidiuretic hormone secretion	A state of increased circulating antidiuretic hormone despite hyponatremia and hypo-osmolality with normal or increased plasma volume.		hp.json	Syndrome of inappropriate antidiuretic hormone secretion|Inappropriate ADH secretion|SIADH	http://purl.obolibrary.org/obo/HP_0031218		
HP:0006207	biolink:PhenotypicFeature	Partial fusion of carpals		UMLS:C1844519	hp.json		http://purl.obolibrary.org/obo/HP_0006207		
HP:0031219	biolink:PhenotypicFeature	Reduced radioactive iodine uptake	A decreased amount of uptake on the radioactive iodine uptake (RAIU) test, which utilizes a radioisotope of iodine to measure how much iodine the thyroid gland absorbs from the blood. The radioactive marker is measured 4-6 hours and in some cases also 24 hours after administration of the radioactive marker.		hp.json		http://purl.obolibrary.org/obo/HP_0031219		
GO:0010595	biolink:BiologicalProcess	positive regulation of endothelial cell migration	Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.		hp.json		http://purl.obolibrary.org/obo/GO_0010595		
HP:0006208	biolink:PhenotypicFeature	Metaphyseal cupping of proximal phalanges	Metaphyseal cupping affecting the proximal phalanges.	UMLS:C1834980	hp.json		http://purl.obolibrary.org/obo/HP_0006208		
HP:0006209	biolink:PhenotypicFeature	Partial-complete absence of 5th phalanges		UMLS:C1867928	hp.json	Partial-complete absence of 5th digital bone	http://purl.obolibrary.org/obo/HP_0006209		
HP:0033877	biolink:PhenotypicFeature	Arcuate vein intraluminal thrombi	Mixture of fibrin, red blood cells, platelets partly or completely occluding the vascular lumen of the arcuate veins of the kidney.		hp.json	Intraluminal thrombi within arcuate veins	http://purl.obolibrary.org/obo/HP_0033877		
HP:0006203	biolink:PhenotypicFeature	Decreased movement range in interphalangeal joints		UMLS:C1836772	hp.json	Decreased range of movement range in hinge joints	http://purl.obolibrary.org/obo/HP_0006203		
HP:0031214	biolink:PhenotypicFeature	Decreased circulating dehydroepiandrosterone concentration			hp.json	Decreased circulating dehydroepiandrosterone level	http://purl.obolibrary.org/obo/HP_0031214		
HP:0008866	biolink:PhenotypicFeature	Failure to thrive secondary to recurrent infections	Insufficient weight gain or inappropriate weight loss for a child, that is attributed to an endogenous recurrent infections.	UMLS:C1832323	hp.json	Weight faltering secondary to recurrent infections|Faltering weight secondary to recurrent infections	http://purl.obolibrary.org/obo/HP_0008866		
HP:0033876	biolink:PhenotypicFeature	Arcuate vein lumen cholesterol emboli	Needle-like or slit-like clefts within the interior space of arcuate veins of the kidney. Cholesterol emboli are visualized as clear spaces (cholesterol clefts) where the cholesterol crystals have been dissolved by routine processing. Acute lesions can be accompanied by inflammation and fibrin.		hp.json	Cholesterol emboli within arcuate vein lumen	http://purl.obolibrary.org/obo/HP_0033876		
HP:0031215	biolink:PhenotypicFeature	Decreased circulating dehydroepiandrosterone-sulfate concentration	A reduced concentration of dehydroepiandrosterone-sulfate in the blood.		hp.json	Decreased circulating dehydroepiandrosterone-sulfate level	http://purl.obolibrary.org/obo/HP_0031215		
HP:0033879	biolink:PhenotypicFeature	Abnormal arcuate vein intima/media morphology	Any structural anomaly located in the inner or middle layer of the arcuate veins of the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033879		
GO:0010596	biolink:BiologicalProcess	negative regulation of endothelial cell migration	Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.		hp.json		http://purl.obolibrary.org/obo/GO_0010596		
HP:0031216	biolink:PhenotypicFeature	Increased circulating progesterone	An elevated concentration of progesterone in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031216		
HP:0006205	biolink:PhenotypicFeature	Irregular phalanges	Alteration of the normally smooth radiographic contour of phalanges producing an irregular appearance.	UMLS:C4025081	hp.json	Irregular finger bones	http://purl.obolibrary.org/obo/HP_0006205		
NCBITaxon:117571	biolink:OrganismalEntity	Euteleostomi		GC_ID:1	hp.json	bony vertebrates	http://purl.obolibrary.org/obo/NCBITaxon_117571		
HP:0033878	biolink:PhenotypicFeature	Arcuate vein lumen organized thrombi	Thrombi containg fibrous tissue and capillary-like vascular channels located within the lumen of the arcuate veins of the kidney.		hp.json	Organized thrombi within arcuate vein lumen	http://purl.obolibrary.org/obo/HP_0033878		
HP:0031217	biolink:PhenotypicFeature	Hot flashes	Sudden feelings of warmth that are generally most pronounced over the face, neck and chest.		hp.json		http://purl.obolibrary.org/obo/HP_0031217		
NCBITaxon:117570	biolink:OrganismalEntity	Teleostomi		GC_ID:1	hp.json		http://purl.obolibrary.org/obo/NCBITaxon_117570		
HP:0006206	biolink:PhenotypicFeature	Hypersegmentation of proximal phalanx of second finger	Presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the second finger.	UMLS:C4025080	hp.json		http://purl.obolibrary.org/obo/HP_0006206		
HP:0006200	biolink:PhenotypicFeature	Widened distal phalanges		UMLS:C1862421	hp.json	Widened outermost bone of limb	http://purl.obolibrary.org/obo/HP_0006200		
HP:0006201	biolink:PhenotypicFeature	Hypermobility of distal interphalangeal joints		UMLS:C1851811	hp.json	Increased mobility of outermost hinge joint	http://purl.obolibrary.org/obo/HP_0006201		
HP:0006202	biolink:PhenotypicFeature	Osteolysis of scaphoids		UMLS:C4025082	hp.json		http://purl.obolibrary.org/obo/HP_0006202		
GO:0010567	biolink:BiologicalProcess	regulation of ketone catabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells.		hp.json		http://purl.obolibrary.org/obo/GO_0010567		
GO:0009581	biolink:BiologicalProcess	detection of external stimulus	The series of events in which an external stimulus is received by a cell and converted into a molecular signal.		hp.json	perception of external stimulus	http://purl.obolibrary.org/obo/GO_0009581		
GO:0009582	biolink:BiologicalProcess	detection of abiotic stimulus	The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.		hp.json	perception of abiotic stimulus	http://purl.obolibrary.org/obo/GO_0009582		
CHEBI:35179	biolink:ChemicalSubstance	2-oxo monocarboxylic acid anion	An oxo monocarboxylic acid anion in which the oxo group is located at the 2-position.	PMID:10850983|MetaCyc:2-Oxo-carboxylates	hp.json	2-oxo monocarboxylate|a 2-oxocarboxylate|2-oxo monocarboxylic acid anions	http://purl.obolibrary.org/obo/CHEBI_35179		3_STAR
GO:0010561	biolink:BiologicalProcess	negative regulation of glycoprotein biosynthetic process	Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.		hp.json		http://purl.obolibrary.org/obo/GO_0010561		
HP:0033804	biolink:PhenotypicFeature	Subepidermal blistering	A type of blistering in which the lesions are located beneath the epidermis.		hp.json		http://purl.obolibrary.org/obo/HP_0033804		
HP:0033803	biolink:PhenotypicFeature	Sub-lamina densa cleavage	A type of blistering in which the cleavage plane of blisters is located below the lamina densa.		hp.json	Blistering with sub-lamina densa plane of cleavage	http://purl.obolibrary.org/obo/HP_0033803		
GO:0010562	biolink:BiologicalProcess	positive regulation of phosphorus metabolic process	Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.		hp.json		http://purl.obolibrary.org/obo/GO_0010562		
HP:0033806	biolink:PhenotypicFeature	Abnormal epidermis stratum granulosum morphology	An abnormal structure of the stratum granulosum, which is is a thin layer of cells in the epidermis lying above the stratum spinosum and below the stratum corneum.		hp.json		http://purl.obolibrary.org/obo/HP_0033806		
HP:0033805	biolink:PhenotypicFeature	Non-necrotizing granuloma	A granuloma which is not associated with necrotic changes.		hp.json		http://purl.obolibrary.org/obo/HP_0033805		
GO:0010560	biolink:BiologicalProcess	positive regulation of glycoprotein biosynthetic process	Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.		hp.json		http://purl.obolibrary.org/obo/GO_0010560		
HP:0033800	biolink:PhenotypicFeature	Blistering by anatomical location	Blistering (presence of multiple fluid filled blisters) categorized according to the body site where they occur.		hp.json		http://purl.obolibrary.org/obo/HP_0033800		
GO:0010565	biolink:BiologicalProcess	regulation of cellular ketone metabolic process	Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.		hp.json		http://purl.obolibrary.org/obo/GO_0010565		
GO:0010566	biolink:BiologicalProcess	regulation of ketone biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells.		hp.json		http://purl.obolibrary.org/obo/GO_0010566		
GO:0010563	biolink:BiologicalProcess	negative regulation of phosphorus metabolic process	Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.		hp.json		http://purl.obolibrary.org/obo/GO_0010563		
HP:0033802	biolink:PhenotypicFeature	Intra-epidermal blistering	A type of blistering in which the lesions are located within the epidermis with loss of cell-cell adhesion of keratinocytes. In simplex EB, cleave occurs in the basal layer, which is the innermost layer of the epidermis and consists of a single layer of basal germinative cells (mostly epidermal Keratinocytes) that proliferate and thereby produce new cells for other epidermal layers. As the cells move towards the upper layers of the epidermis they mature and eventually form cornified cells. The suprabasal cell layer lies directly above the basal layer and is composed of five to ten layers of cells.		hp.json		http://purl.obolibrary.org/obo/HP_0033802		
HP:0033801	biolink:PhenotypicFeature	Blistering by histological location	Blistering (presence of multiple fluid filled blisters) categorized according to the layer of the skin in which the blister originates. The skin is divided into three layers. The epidermis (outermost layer, which mainly consists of keratinocytes), the dermis, and a subcutaneous layer. The epidermis is divided into five layers: the basal lamina (innermost layer), the basal cell layer, the stratum spinosum, the stratum granulosum, and the stratum corneum (outermost layer). Cleavage in epidermolysis bullosa (EB) simplex occurs within the basal keratinocytes; in junctional EB, within the lamina lucida; and in dystrophic EB occurs in the sublamina densa, in the upper portion of the dermis (papillary dermis). In Kindler's EB, cleavage can occur in the basal keratinocytes, in the lamina lucida, or below the lamina densa.		hp.json		http://purl.obolibrary.org/obo/HP_0033801		
GO:0010564	biolink:BiologicalProcess	regulation of cell cycle process	Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.		hp.json		http://purl.obolibrary.org/obo/GO_0010564		
HP:0006254	biolink:PhenotypicFeature	Elevated alpha-fetoprotein	An increased concentration of alpha-fetoprotein.	UMLS:C0476489|UMLS:C0235971	hp.json	Increased levels of alpha fetoprotein|Alpha fetoprotein abnormal|Increased serum alpha-fetoprotein|Serum alpha-fetoprotein increased	http://purl.obolibrary.org/obo/HP_0006254		
HP:0006256	biolink:PhenotypicFeature	Abnormality of hand joint mobility		UMLS:C4025076	hp.json	Abnormality of hand joint mobility	http://purl.obolibrary.org/obo/HP_0006256		
HP:0006257	biolink:PhenotypicFeature	Abnormality of carpal bone ossification		UMLS:C4025075	hp.json	Abnormal wrist bone maturation	http://purl.obolibrary.org/obo/HP_0006257		
HP:0033808	biolink:PhenotypicFeature	Spermatocele	A cystic structure arising from the epididymis, rete testis or efferent ductuli. These structures are filled with spermatozoa containing fluid that may be milky. These cysts are usually outside the tunica vaginalis and, as with hydrocele, transluminate easily.		hp.json		http://purl.obolibrary.org/obo/HP_0033808		
HP:0033807	biolink:PhenotypicFeature	Absent keratohyalin granules	Lack of keratohyalin granules, which are normally present in the stratum granulosum of the epidermal layer of the skin.		hp.json		http://purl.obolibrary.org/obo/HP_0033807		
HP:0006251	biolink:PhenotypicFeature	Limited wrist extension		UMLS:C1862481	hp.json		http://purl.obolibrary.org/obo/HP_0006251		
HP:0006252	biolink:PhenotypicFeature	Interphalangeal joint erosions		UMLS:C1850158	hp.json		http://purl.obolibrary.org/obo/HP_0006252		
HP:0006253	biolink:PhenotypicFeature	Swelling of proximal interphalangeal joints		UMLS:C1860841	hp.json	Swelling of innermost hinge joints	http://purl.obolibrary.org/obo/HP_0006253		
HP:0033809	biolink:PhenotypicFeature	Increased circulating 17 hydroxypregnenolone concentration	Increased concentration of 17alpha-hydroxypregnenolone in the blood circulation. 17alpha-hydroxypregnenolone is a 21-carbon steroid that is converted from pregnenolone by steroid 17-alpha-hydroxylase, as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids.		hp.json		http://purl.obolibrary.org/obo/HP_0033809		
HP:0006270	biolink:PhenotypicFeature	Hypoplastic spleen	Underdevelopment of the spleen.	UMLS:C1970617	hp.json	Underdeveloped spleen	http://purl.obolibrary.org/obo/HP_0006270		
CHEBI:35191	biolink:ChemicalSubstance	triterpene			hp.json		http://purl.obolibrary.org/obo/CHEBI_35191		
CHEBI:35190	biolink:ChemicalSubstance	diterpene	A C20 terpene.		hp.json	diterpeno|diterpenos|diterpenes|Diterpen|diterpenes	http://purl.obolibrary.org/obo/CHEBI_35190		3_STAR
GO:0009593	biolink:BiologicalProcess	detection of chemical stimulus	The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.		hp.json	perception of chemical stimulus|detection of chemical substance|perception of chemical substance|chemoreception|chemoperception	http://purl.obolibrary.org/obo/GO_0009593		
GO:0009583	biolink:BiologicalProcess	detection of light stimulus	The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.		hp.json	detection of light|perception of light	http://purl.obolibrary.org/obo/GO_0009583		
HP:0033815	biolink:PhenotypicFeature	Bronchocentric	Centered in bronchi or bronchioles.		hp.json		http://purl.obolibrary.org/obo/HP_0033815		
GO:0010572	biolink:BiologicalProcess	positive regulation of platelet activation	Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0010572		
HP:0033814	biolink:PhenotypicFeature	Paraseptal	Characterized by predominant involvement of the distal alveoli and their ducts and sacs. It is characteristically bounded by any pleural surface and the interlobular septa.		hp.json		http://purl.obolibrary.org/obo/HP_0033814		
GO:0009584	biolink:BiologicalProcess	detection of visible light	The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.		hp.json	perception of visible light	http://purl.obolibrary.org/obo/GO_0009584		
HP:0033817	biolink:PhenotypicFeature	Miliary	Characterized by numerous small lesions said to resemble millet seed.		hp.json		http://purl.obolibrary.org/obo/HP_0033817		
CHEBI:59132	biolink:ChemicalSubstance	antigen	Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC).		hp.json	antigens	http://purl.obolibrary.org/obo/CHEBI_59132		3_STAR
HP:0033816	biolink:PhenotypicFeature	Centrilobular	Located in the center of the secondary pulmonary lobules, which are the functional units of the lungs.		hp.json		http://purl.obolibrary.org/obo/HP_0033816		
HP:0033811	biolink:PhenotypicFeature	Abnormal circulating androstenedione concentration	Any deviation from the normal concentration of androstenedione in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033811		
HP:0033810	biolink:PhenotypicFeature	Decreased circulating dihydrotestosterone concentration	A reduced concentration of dihydrotestosterone in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033810		
HP:0033813	biolink:PhenotypicFeature	Perilobular	Situated or occurring around a lobe of an organ.		hp.json		http://purl.obolibrary.org/obo/HP_0033813		
HP:0033812	biolink:PhenotypicFeature	Decreased circulating androstenedione concentration	Reduced concentration of androstenedione in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0033812		
HP:0006265	biolink:PhenotypicFeature	Aplasia/Hypoplasia of fingers	Small/hypoplastic or absent/aplastic fingers.	UMLS:C4025071	hp.json	Absent/underdeveloped fingers|Absent/small fingers	http://purl.obolibrary.org/obo/HP_0006265		
HP:0006266	biolink:PhenotypicFeature	Small placenta	Reduced size of the placenta.	UMLS:C0566694|SNOMEDCT_US:289264006	hp.json	Small placenta	http://purl.obolibrary.org/obo/HP_0006266		
HP:0006267	biolink:PhenotypicFeature	Large placenta	Increased size of the placenta.	SNOMEDCT_US:289263000|UMLS:C0566693	hp.json	Large placenta|Placental enlargement	http://purl.obolibrary.org/obo/HP_0006267		
HP:0006268	biolink:PhenotypicFeature	Fluctuating splenomegaly	Intermittently increased size of the spleen.	UMLS:C1835882	hp.json		http://purl.obolibrary.org/obo/HP_0006268		
CHEBI:35186	biolink:ChemicalSubstance	terpene	A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH2=C(CH3)CH=CH2].		hp.json	terpenos|terpeno|Terpen|terpenes|terpenes|terpene	http://purl.obolibrary.org/obo/CHEBI_35186		3_STAR
HP:0006261	biolink:PhenotypicFeature	Abnormal phalangeal joint morphology of the hand		UMLS:C4021604	hp.json	Abnormality of the small joints of the hand|Abnormality of phalangeal joints of the hand	http://purl.obolibrary.org/obo/HP_0006261		
HP:0033819	biolink:PhenotypicFeature	Perilymphatic	Applies to an abnormality whose distribution and appearance are located at or near lymphatic structures (node or vessel).		hp.json		http://purl.obolibrary.org/obo/HP_0033819		
HP:0006262	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 5th finger	A small/hypoplastic or absent/aplastic 5th finger.	UMLS:C4025074	hp.json	Absent/small pinky finger|Absent/small little finger|Absent/underdeveloped pinkie finger|Absent/underdeveloped little finger|Absent/underdeveloped pinky finger|Absent/small pinkie finger	http://purl.obolibrary.org/obo/HP_0006262		
HP:0033818	biolink:PhenotypicFeature	Reticular	Applies to an abnormality whose distribution and appearance resembles a net or network-like structure.		hp.json		http://purl.obolibrary.org/obo/HP_0033818		
HP:0006263	biolink:PhenotypicFeature	Abnormality of the epiphyses of the 2nd finger	Abnormality of one or all of the epiphyses of the proximal, middle, and distal phalanges of the 2nd finger.	UMLS:C4025073	hp.json	Abnormality of the end part of the index finger bone	http://purl.obolibrary.org/obo/HP_0006263		
HP:0006264	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the 2nd finger	A small/hypoplastic or absent/aplastic 2nd finger.	UMLS:C4025072	hp.json	Absent/small index finger|Absent/underdeveloped index finger	http://purl.obolibrary.org/obo/HP_0006264		
HP:0033820	biolink:PhenotypicFeature	Apical	Applies to an abnormality whose distribution and appearance are located at the apex of an organ. For instance, apical refers to the superior portion of the lung.		hp.json		http://purl.obolibrary.org/obo/HP_0033820		
PATO:0000502	biolink:NamedThing	delayed	A quality of a process which starts later than the natural start time or the reference process.		hp.json	late	http://purl.obolibrary.org/obo/PATO_0000502		value_slim
GO:0010549	biolink:BiologicalProcess	regulation of membrane disassembly	Any process that modulates the frequency, rate or extent of membrane disassembly.		hp.json		http://purl.obolibrary.org/obo/GO_0010549		
HP:0033826	biolink:PhenotypicFeature	Inferior mediastinal mass	A type of mediastinal mass that is located below the thoracic plane (a horizontal line that runs from the manubriosternal joint (sternal angle or angle of Louis) to the inferior endplate of T4).		hp.json		http://purl.obolibrary.org/obo/HP_0033826		
HP:0033825	biolink:PhenotypicFeature	Superior mediastinal mass	A type of mediastinal mass that is located above the thoracic plane (a horizontal line that runs from the manubriosternal joint (sternal angle or angle of Louis) to the inferior endplate of T4).		hp.json		http://purl.obolibrary.org/obo/HP_0033825		
HP:0033828	biolink:PhenotypicFeature	Middle mediastinal mass	A type of inferior mediastinal mass that is located withinthe pericardium.		hp.json		http://purl.obolibrary.org/obo/HP_0033828		
HP:0033827	biolink:PhenotypicFeature	Anterior mediastinal mass	A type of inferior mediastinal mass that is located in front of the pericardium.		hp.json		http://purl.obolibrary.org/obo/HP_0033827		
HP:0033822	biolink:PhenotypicFeature	Mass on thoracic imaging	A mass is any pulmonary, pleural, or mediastinal lesion seen on chest radiographs as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics). Mass usually implies a solid or partly solid opacity. CT allows more exact evaluation of size, location, attenuation, and other features.		hp.json		http://purl.obolibrary.org/obo/HP_0033822		
HP:0006236	biolink:PhenotypicFeature	Slender metacarpals	Decreased width of the metacarpal bones (that is, reduced diameter).	UMLS:C4025077	hp.json	Slender long bones of hand	http://purl.obolibrary.org/obo/HP_0006236		
GO:0010543	biolink:BiologicalProcess	regulation of platelet activation	Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0010543		
HP:0033821	biolink:PhenotypicFeature	Pulmonary mass	A mass in the lung seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics).		hp.json		http://purl.obolibrary.org/obo/HP_0033821		
HP:0006237	biolink:PhenotypicFeature	Prominent interphalangeal joints		UMLS:C1859115	hp.json	Prominent hinge joints	http://purl.obolibrary.org/obo/HP_0006237		
GO:0010544	biolink:BiologicalProcess	negative regulation of platelet activation	Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0010544		
HP:0033824	biolink:PhenotypicFeature	Pleural mass	A mass in the pleura seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics).		hp.json		http://purl.obolibrary.org/obo/HP_0033824		
HP:0006239	biolink:PhenotypicFeature	Shortening of all middle phalanges of the toes	Abnormal shortening of all middle phalanges of toes.	UMLS:C4021605	hp.json	Shortening of all the middle bones of the toes|Brachymesophalangy of feet	http://purl.obolibrary.org/obo/HP_0006239		
HP:0033823	biolink:PhenotypicFeature	Mediastinal mass	A mass in the mediastinum seen on chest imaging is defined as an opacity greater than 3 cm in diameter (without regard to contour, border, or density characteristics).		hp.json		http://purl.obolibrary.org/obo/HP_0033823		
HP:0006232	biolink:PhenotypicFeature	Expanded metacarpals with widened medullary cavities		UMLS:C1969288	hp.json		http://purl.obolibrary.org/obo/HP_0006232		
HP:0006233	biolink:PhenotypicFeature	Osteoarthritis of the distal interphalangeal joint		SNOMEDCT_US:239869009|UMLS:C0409957	hp.json		http://purl.obolibrary.org/obo/HP_0006233		
HP:0006234	biolink:PhenotypicFeature	Osteolysis involving tarsal bones	An increased resorption of bone matrix by osteoclasts leading to bony defects involving the tarsal bones.	UMLS:C1833735	hp.json	Tarsal osteolysis|Tarsal bone osteolysis	http://purl.obolibrary.org/obo/HP_0006234		
HP:0008897	biolink:PhenotypicFeature	Postnatal growth retardation	Slow or limited growth after birth.	UMLS:C1859778	hp.json	Postnatal growth failure|Postnatal growth deceleration|Growth delay as children|Postnatal growth deficiency|Growth retardation as children	http://purl.obolibrary.org/obo/HP_0008897		
HP:0008890	biolink:PhenotypicFeature	Severe short-limb dwarfism		UMLS:C1860105	hp.json		http://purl.obolibrary.org/obo/HP_0008890		
HP:0033829	biolink:PhenotypicFeature	Posterior mediastinal mass	A type of inferior mediastinal mass that is located behind the pericardium.		hp.json		http://purl.obolibrary.org/obo/HP_0033829		
HP:0006230	biolink:PhenotypicFeature	Unilateral oligodactyly		UMLS:C3805861	hp.json		http://purl.obolibrary.org/obo/HP_0006230		
PR:Q64314	biolink:Protein	hematopoietic progenitor cell antigen CD34 (mouse)	A CD34 molecule that is encoded in the genome of mouse.	UniProtKB:Q64314	hp.json	mCD34|CD34 (mouse)|Cd34	http://purl.obolibrary.org/obo/PR_Q64314		
GO:0010558	biolink:BiologicalProcess	negative regulation of macromolecule biosynthetic process	Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.		hp.json		http://purl.obolibrary.org/obo/GO_0010558		
GO:0034504	biolink:BiologicalProcess	protein localization to nucleus	A process in which a protein transports or maintains the localization of another protein to the nucleus.		hp.json	protein localization in cell nucleus|protein targeting to nucleus|protein localization in nucleus|protein localisation to nucleus	http://purl.obolibrary.org/obo/GO_0034504		
GO:0010559	biolink:BiologicalProcess	regulation of glycoprotein biosynthetic process	Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.		hp.json		http://purl.obolibrary.org/obo/GO_0010559		
HP:0033831	biolink:PhenotypicFeature	Cavitating pulmonary mass	Thick-walled abnormal gas-filled interstitial mass within a lung with a diameter greater than 30 mm.		hp.json		http://purl.obolibrary.org/obo/HP_0033831		
GO:0034505	biolink:BiologicalProcess	tooth mineralization	The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum.		hp.json	tooth calcification	http://purl.obolibrary.org/obo/GO_0034505		
GO:0010556	biolink:BiologicalProcess	regulation of macromolecule biosynthetic process	Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.		hp.json		http://purl.obolibrary.org/obo/GO_0010556		
GO:0010557	biolink:BiologicalProcess	positive regulation of macromolecule biosynthetic process	Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.		hp.json		http://purl.obolibrary.org/obo/GO_0010557		
HP:0033830	biolink:PhenotypicFeature	Hyperdense pulmonary mass	A type of pulmonary mass with high attenuation.		hp.json		http://purl.obolibrary.org/obo/HP_0033830		
PATO:0000516	biolink:NamedThing	sensitive toward	A quality inhering in a bearer by virtue of the bearer's having sensitivity toward an external stimulus.		hp.json	sensitive	http://purl.obolibrary.org/obo/PATO_0000516		disposition_slim|relational_slim|value_slim
HP:0033837	biolink:PhenotypicFeature	Abnormal arcuate artery morphology	Anomalous structure of the arc-shaped arteries located at the border of the renal cortex and renal medulla.		hp.json	Abnormalities of arcuate arteries	http://purl.obolibrary.org/obo/HP_0033837		
HP:0033836	biolink:PhenotypicFeature	Abnormal intrarenal artery morphology	An anomalous structure of an artery located in the kidney.		hp.json	Abnormal kidney arterial blood vessel morphology	http://purl.obolibrary.org/obo/HP_0033836		
HP:0033839	biolink:PhenotypicFeature	Testicular pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to one or both testes.		hp.json	Pain in testicles	http://purl.obolibrary.org/obo/HP_0033839		
HP:0033838	biolink:PhenotypicFeature	Dysphoria	A state of feeling very unhappy, uneasy, or dissatisfied.		hp.json		http://purl.obolibrary.org/obo/HP_0033838		
HP:0033833	biolink:PhenotypicFeature	Elevated circulating soluble CD25 concentration	Increased concentration of the interleukin-2 receptor alpha-chain (CD25) in the blood circulation. CD25 is shed upon immune activation. Increased levels of soluble CD25, therefore, are an indication of an on-going immune response.		hp.json	Elevated circulating interleukin-2 receptor alpha-chain	http://purl.obolibrary.org/obo/HP_0033833		
HP:0006247	biolink:PhenotypicFeature	Enlarged interphalangeal joints		UMLS:C1859701	hp.json	Enlarged hinge joints	http://purl.obolibrary.org/obo/HP_0006247		
GO:0009566	biolink:BiologicalProcess	fertilization	The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).	Wikipedia:Fertilisation	hp.json	syngamy	http://purl.obolibrary.org/obo/GO_0009566		
HP:0033832	biolink:PhenotypicFeature	Livedo	A reddish-blue mottled condition of skin caused by inflammation of the cutaneous blood vessels.		hp.json	Livedoid dermatitis	http://purl.obolibrary.org/obo/HP_0033832		
HP:0006248	biolink:PhenotypicFeature	Limited wrist movement	An abnormal limitation of the mobility of the wrist.	UMLS:C1840088	hp.json	Limited wrist movement|Limited movement of the wrist	http://purl.obolibrary.org/obo/HP_0006248		hposlim_core
HP:0033835	biolink:PhenotypicFeature	Abnormal renal vascular morphology	Anomalous structure of a blood vessel in the kidney.		hp.json		http://purl.obolibrary.org/obo/HP_0033835		
HP:0033834	biolink:PhenotypicFeature	Malaise	A feeling of general discomfort, weakness, or lack of health.		hp.json		http://purl.obolibrary.org/obo/HP_0033834		
GO:0034502	biolink:BiologicalProcess	protein localization to chromosome	Any process in which a protein is transported to, or maintained at, a specific location on a chromosome.		hp.json	protein localisation to chromosome|condensin localization to chromosome	http://purl.obolibrary.org/obo/GO_0034502		
HP:0006243	biolink:PhenotypicFeature	Phalangeal dislocation		UMLS:C2673396	hp.json		http://purl.obolibrary.org/obo/HP_0006243		
GO:1900367	biolink:BiologicalProcess	positive regulation of defense response to insect	Any process that activates or increases the frequency, rate or extent of defense response to insect.		hp.json	upregulation of defense response to insect|upregulation of physiological defense response to insect|positive regulation of physiological defense response to insect|up regulation of defense response to insect|up regulation of physiological defense response to insect|up-regulation of defense response to insect|up-regulation of physiological defense response to insect|activation of defense response to insect|activation of physiological defense response to insect	http://purl.obolibrary.org/obo/GO_1900367		
GO:1900366	biolink:BiologicalProcess	negative regulation of defense response to insect	Any process that stops, prevents or reduces the frequency, rate or extent of defense response to insect.		hp.json	inhibition of physiological defense response to insect|down-regulation of defense response to insect|negative regulation of physiological defense response to insect|down-regulation of physiological defense response to insect|downregulation of defense response to insect|susceptibility to insect|downregulation of physiological defense response to insect|down regulation of defense response to insect|down regulation of physiological defense response to insect|inhibition of defense response to insect	http://purl.obolibrary.org/obo/GO_1900366		
HP:0008808	biolink:PhenotypicFeature	High iliac wing	Increased height of the wing (or ala) of the ilium (which is the large expanded portion which bounds the greater pelvis laterally).	UMLS:C1969680	hp.json	High iliac wings|Narrow, high iliac wings	http://purl.obolibrary.org/obo/HP_0008808		
HP:0008807	biolink:PhenotypicFeature	Acetabular dysplasia	A smaller than normal acetabulum that has insufficient femoral head coverage leading to abnormal hip joint contact pressures, instability and pain.	MSH:D006617|UMLS:C1328407	hp.json	Dysplastic acetabulae	http://purl.obolibrary.org/obo/HP_0008807		
HP:0008804	biolink:PhenotypicFeature	Broad femoral head	Increased width of the femoral head.	UMLS:C4024619	hp.json	Wide head of thigh bone	http://purl.obolibrary.org/obo/HP_0008804		
HP:0008803	biolink:PhenotypicFeature	obsolete Narrow sacroiliac notch			hp.json		http://purl.obolibrary.org/obo/HP_0008803		
HP:0008800	biolink:PhenotypicFeature	Limited hip movement	A decreased ability to move the femur at the hip joint associated with a decreased range of motion of the hip.	UMLS:C1851542	hp.json	Limited hip movement	http://purl.obolibrary.org/obo/HP_0008800		
HP:0008802	biolink:PhenotypicFeature	Hypoplasia of the femoral head	Underdevelopment of the femoral head.	UMLS:C1856920	hp.json	Hypoplastic femoral head|Small head of thigh bone|Small femoral heads	http://purl.obolibrary.org/obo/HP_0008802		
HP:0008801	biolink:PhenotypicFeature	Hypoplasia of the lesser trochanter	Underdevelopment of the lesser trochanter.	UMLS:C1840062	hp.json	Lesser trochanter hypoplasia	http://purl.obolibrary.org/obo/HP_0008801		
GO:0071495	biolink:BiologicalProcess	cellular response to endogenous stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.		hp.json		http://purl.obolibrary.org/obo/GO_0071495		gocheck_do_not_manually_annotate
HP:0008839	biolink:PhenotypicFeature	Hypoplastic pelvis	Underdevelopment of the bony pelvis.	UMLS:C3536734	hp.json	Hypoplastic pelvic bones|Small pelvis	http://purl.obolibrary.org/obo/HP_0008839		hposlim_core
OIO:SynonymTypeProperty	biolink:NamedThing	synonym_type_property			hp.json		http://www.geneontology.org/formats/oboInOwl#SynonymTypeProperty		
HP:0008838	biolink:PhenotypicFeature	Stippled calcification proximal humeral epiphyses		UMLS:C1857243	hp.json	Speckled calcifications in end part of innermost long bone of upper arm	http://purl.obolibrary.org/obo/HP_0008838		
HP:0008833	biolink:PhenotypicFeature	Irregular acetabular roof		UMLS:C1834975	hp.json		http://purl.obolibrary.org/obo/HP_0008833		
HP:0008835	biolink:PhenotypicFeature	Multicentric femoral head ossification	There is normally one ossification center in the head of the femur. This term applies if there are multiple such centers.	UMLS:C1846447	hp.json		http://purl.obolibrary.org/obo/HP_0008835		
HP:0008830	biolink:PhenotypicFeature	Hypoplastic pubic rami		UMLS:C1969176	hp.json		http://purl.obolibrary.org/obo/HP_0008830		
HP:0008848	biolink:PhenotypicFeature	Moderately short stature	A moderate degree of short stature, more than -3 SD but not more than -4 SD from mean corrected for age and sex.	UMLS:C1861519	hp.json	Moderate short stature|Short stature, moderate	http://purl.obolibrary.org/obo/HP_0008848		
GO:0034486	biolink:BiologicalProcess	vacuolar transmembrane transport	The process in which a solute is transported from one side of the vacuolar membrane to the other.		hp.json	vacuolar membrane transport	http://purl.obolibrary.org/obo/GO_0034486		
GO:0034487	biolink:BiologicalProcess	vacuolar amino acid transmembrane transport	The process in which an amino acid is transported from one side of the vacuolar membrane to the other.		hp.json	vacuolar amino acid membrane transport	http://purl.obolibrary.org/obo/GO_0034487		
HP:0008843	biolink:PhenotypicFeature	Hip osteoarthritis		UMLS:C0029410|SNOMEDCT_US:239872002|MSH:D015207	hp.json	Osteoarthritis of hip	http://purl.obolibrary.org/obo/HP_0008843		
HP:0008846	biolink:PhenotypicFeature	Severe intrauterine growth retardation	Intrauterine growth retardation that is 4 or more standard deviations below average, corrected for sex and gestational age.	UMLS:C1855843	hp.json	Severe prenatal growth deficiency|Intrauterine growth retardation, severe	http://purl.obolibrary.org/obo/HP_0008846		
HP:0008845	biolink:PhenotypicFeature	Mesomelic short stature	A type of disproportionate short stature characterized by disproportionate shortening of the medial parts of the extremities (forearm or lower leg).	UMLS:C1855274	hp.json	Mesomelic dwarfism|Short stature, disproportionate mesomelic|Short stature, mesomelic|Dwarfism, short limb mesomelic	http://purl.obolibrary.org/obo/HP_0008845		
PR:Q9QXH4	biolink:Protein	integrin alpha-X (mouse)	An integrin alpha-X that is encoded in the genome of mouse.	UniProtKB:Q9QXH4	hp.json	Itgax|CD11c (mouse)|mITGAX|leukocyte adhesion glycoprotein p150,95 alpha chain (mouse)|CD11 antigen-like family member C (mouse)|leukocyte adhesion receptor p150,95 (mouse)	http://purl.obolibrary.org/obo/PR_Q9QXH4		
HP:0008819	biolink:PhenotypicFeature	Narrow femoral neck	An abnormally reduced diameter of the femoral neck (which is the process of bone, connecting the femoral head with the femoral shaft).	UMLS:C1863739	hp.json	Narrow neck of thigh bone|Narrow femoral necks	http://purl.obolibrary.org/obo/HP_0008819		
HP:0008818	biolink:PhenotypicFeature	Large iliac wing	Increased size of the ilium ala.	UMLS:C4024618	hp.json	Large iliac wings	http://purl.obolibrary.org/obo/HP_0008818		
HP:0008817	biolink:PhenotypicFeature	Aplastic pubic bones		UMLS:C1848660	hp.json	Absent pubic bones	http://purl.obolibrary.org/obo/HP_0008817		
HP:0008812	biolink:PhenotypicFeature	Flattened femoral head	An abnormally flattened femoral head.	UMLS:C1860601	hp.json	Flattened femoral heads|Flat head of thigh bone	http://purl.obolibrary.org/obo/HP_0008812		
HP:0008829	biolink:PhenotypicFeature	Delayed femoral head ossification	Delayed ossification of the femoral head.	UMLS:C1846446|UMLS:C4280410	hp.json	Delayed maturation of the head of the thigh bone	http://purl.obolibrary.org/obo/HP_0008829		
HP:0008826	biolink:PhenotypicFeature	Dislocation of the femoral head	Joint dislocation of the femoral head.	UMLS:C1859446	hp.json	Dislocated head of thigh bone|Dislocated femoral heads	http://purl.obolibrary.org/obo/HP_0008826		
HP:0008828	biolink:PhenotypicFeature	Delayed proximal femoral epiphyseal ossification	Developmental delay of ossification of the proximal epiphysis of the femur.	UMLS:C1855222	hp.json	Delayed ossification proximal femoral epiphyses|Delayed ossification of the proximal femoral epiphysis	http://purl.obolibrary.org/obo/HP_0008828		
HP:0008822	biolink:PhenotypicFeature	Hypoplastic ischiopubic rami	Underdevelopment of the ischiopubic ramus, which is comprised of the inferior pubic ramus and the inferior ramus of the ischium.	UMLS:C4024617	hp.json		http://purl.obolibrary.org/obo/HP_0008822		
HP:0008821	biolink:PhenotypicFeature	Hypoplastic inferior ilia		UMLS:C1837078	hp.json		http://purl.obolibrary.org/obo/HP_0008821		
HP:0008824	biolink:PhenotypicFeature	Hypoplastic iliac body	Underdevelopment of the body of ilium.	UMLS:C1849034	hp.json	Small iliac bodies|Hypoplastic iliac bodies	http://purl.obolibrary.org/obo/HP_0008824		
HP:0008823	biolink:PhenotypicFeature	Hypoplastic inferior pubic rami		UMLS:C1853573	hp.json		http://purl.obolibrary.org/obo/HP_0008823		
HP:0008820	biolink:PhenotypicFeature	Absent ossification of capital femoral epiphysis	Lack of ossification of the proximal epiphysis of the femur.	UMLS:C1968686	hp.json	Absent ossification of femoral capital epiphyses	http://purl.obolibrary.org/obo/HP_0008820		
CHEBI:60065	biolink:ChemicalSubstance	alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine(1-)	A carbohydrate acid derivative anion that is the conjugate base of alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide arising from deprotonation of the neuraminosyl carboxy group; major species at pH 7.3.		hp.json	alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide|ganglioside GM3 (d18:1(4E))	http://purl.obolibrary.org/obo/CHEBI_60065		3_STAR
CL:0002022	biolink:Cell	Ly-76 high positive erythrocyte	An enucleate erythrocyte that is Lyg-76-high.		hp.json		http://purl.obolibrary.org/obo/CL_0002022		
GO:0071407	biolink:BiologicalProcess	cellular response to organic cyclic compound	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.		hp.json	cellular response to organic cyclic substance	http://purl.obolibrary.org/obo/GO_0071407		
CL:0002028	biolink:Cell	basophil mast progenitor cell	A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa		hp.json	BMCP	http://purl.obolibrary.org/obo/CL_0002028		
CHEBI:25741	biolink:ChemicalSubstance	oxide	An oxide is a chemical compound of oxygen with other chemical elements.		hp.json	oxide|oxides	http://purl.obolibrary.org/obo/CHEBI_25741		3_STAR
CHEBI:60073	biolink:ChemicalSubstance	N-acylneuraminate	A sialic acid anion arising from deprotonation of the carboxy group of an N-acylneuraminic acid; major species at pH 7.3.		hp.json	N-acylneuraminate cation|an N-acylneuraminate|5-alkanamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonate	http://purl.obolibrary.org/obo/CHEBI_60073		3_STAR
CL:0002034	biolink:Cell	long term hematopoietic stem cell	A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative.		hp.json	LT-HSC|LT stem cell	http://purl.obolibrary.org/obo/CL_0002034		
CL:0002033	biolink:Cell	short term hematopoietic stem cell	A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative.		hp.json	ST-HSC|ST stem cell	http://purl.obolibrary.org/obo/CL_0002033		
CL:0002036	biolink:Cell	Slamf1-positive multipotent progenitor cell	A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive.		hp.json	KSL cell	http://purl.obolibrary.org/obo/CL_0002036		
CL:0002035	biolink:Cell	Slamf1-negative multipotent progenitor cell	A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative.		hp.json		http://purl.obolibrary.org/obo/CL_0002035		
CL:0002032	biolink:Cell	hematopoietic oligopotent progenitor cell	A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.		hp.json		http://purl.obolibrary.org/obo/CL_0002032		
CL:0002031	biolink:Cell	hematopoietic lineage restricted progenitor cell	A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.		hp.json		http://purl.obolibrary.org/obo/CL_0002031		
CHEBI:25710	biolink:ChemicalSubstance	organophosphorus compound	An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters.	Wikipedia:Organophosphorus_compound	hp.json	organophosphorus compound|organophosphorus compounds	http://purl.obolibrary.org/obo/CHEBI_25710		3_STAR
CL:0002009	biolink:Cell	macrophage dendritic cell progenitor	A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages.		hp.json	MDP	http://purl.obolibrary.org/obo/CL_0002009		
CL:0002001	biolink:Cell	CD34-positive, CD38-positive granulocyte monocyte progenitor	A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative.		hp.json		http://purl.obolibrary.org/obo/CL_0002001		
CL:0002000	biolink:Cell	Kit-positive erythroid progenitor cell	An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative.		hp.json	c- Kit-positive erythroid progenitor cell	http://purl.obolibrary.org/obo/CL_0002000		
CL:0002005	biolink:Cell	CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell	A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative.		hp.json		http://purl.obolibrary.org/obo/CL_0002005		
CL:0002006	biolink:Cell	Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell	A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low.		hp.json		http://purl.obolibrary.org/obo/CL_0002006		
UBERON:0002588	biolink:AnatomicalEntity	decussation of superior cerebellar peduncle	Regional part of superior cerebellar peduncle located in the caudal midbrain, at the level of the inferior colliculus, consisting of a large bundle of fibers crossing the midline. It contains fibers projecting from the deep cerebellar nucleus to the midbrain and thalamus through the superior cerebellar peduncle (MM). The decussation of superior cerebellar peduncle is the portion of the superior cerebellar peduncle which crosses into the midbrain. [WP,unvetted].	HBA:265505482|BAMS:dscp|DHBA:12337|BIRNLEX:1089|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=527|BAMS:xscp|UMLS:C0152374|MBA:812|FMA:72455|BM:BCX	hp.json	decussation of superior cerebellar peduncles|descussation of the scp|decussatio brachii conjunctivi|decussatio pedunculorum cerebellarium superiorum|decussation of the superior cerebellar peduncle (Wernekinck)|Wernekink's decussation|decussatio crurorum cerebello-cerebralium|decussation of brachium conjunctivum|superior cerebellar peduncle decussation|decussation of the superior cerebellar peduncle	http://purl.obolibrary.org/obo/UBERON_0002588		uberon_slim
GO:0071425	biolink:BiologicalProcess	hematopoietic stem cell proliferation	The expansion of a hematopoietic stem cell population by cell division. A hematopoietic stem cell is a stem cell from which all cells of the lymphoid and myeloid lineages develop.		hp.json	hemopoietic stem cell proliferation	http://purl.obolibrary.org/obo/GO_0071425		
UBERON:0002589	biolink:AnatomicalEntity	lateral corticospinal tract	Part of the corticospinal tract located in the spinal cord, formed as 75 to 90% of the corticospinal fibers cross to the opposite side of the brainstem in the pyramidal decussation. This tract descends the length of the spinal cord in the lateral white column (Adapted from Brain Info).	MBA:1019|DHBA:12759|NCIT:C32406|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=801|BAMS:py|FMA:72635|EMAPA:37888|BAMS:lcsp|BIRNLEX:1095|UMLS:C0152402	hp.json	fasciculus cerebrospinalis lateralis|lateral corticospinal tract of the medulla|tractus corticospinalis (pyramidalis) lateralis|crossed corticospinal tract|pyramidal tract, crossed|corticospinal tract, crossed|crossed pyramidal tract|corticospinal tract, crossed|lateral pyramidal tract|tractus corticospinalis lateralis|lateral corticospinal tract	http://purl.obolibrary.org/obo/UBERON_0002589		uberon_slim|pheno_slim
CL:0002019	biolink:Cell	Ly-76 high reticulocyte	A reticulocyte that is Ly76-high and is Kit-negative.		hp.json		http://purl.obolibrary.org/obo/CL_0002019		
PR:000008175	biolink:Protein	glucose-6-phosphate isomerase	A protein that is a translation product of the human GPI gene or a 1:1 ortholog thereof.		hp.json	NLK|sperm antigen 36|SA-36|PGI|GPI|phosphoglucose isomerase|PHI|phosphohexose isomerase|neuroleukin|AMF|autocrine motility factor|Gpi1	http://purl.obolibrary.org/obo/PR_000008175		
CL:0002012	biolink:Cell	Kit-low proerythroblast	A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive.		hp.json		http://purl.obolibrary.org/obo/CL_0002012		
CL:0002014	biolink:Cell	Kit-negative, Ly-76 high basophilic erythroblast	A basophilic erythroblast that is Lyg 76-high and is Kit-negative.		hp.json		http://purl.obolibrary.org/obo/CL_0002014		
CL:0002015	biolink:Cell	Kit-negative, Ly-76 high polychromatophilic erythroblast	A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative.		hp.json	late basophilic and polychromatophilic erythroblast	http://purl.obolibrary.org/obo/CL_0002015		
GO:0071418	biolink:BiologicalProcess	cellular response to amine stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups.		hp.json		http://purl.obolibrary.org/obo/GO_0071418		
GO:0071417	biolink:BiologicalProcess	cellular response to organonitrogen compound	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.		hp.json	cellular response to organic nitrogen	http://purl.obolibrary.org/obo/GO_0071417		
CL:0002017	biolink:Cell	Kit-negative, Ly-76 high orthochromatophilic erythroblasts	An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative.		hp.json		http://purl.obolibrary.org/obo/CL_0002017		
CHEBI:25728	biolink:ChemicalSubstance	osmolyte	A solute used by a cell under water stress to maintain cell volume.		hp.json	osmolytes	http://purl.obolibrary.org/obo/CHEBI_25728		3_STAR
HP:0031180	biolink:PhenotypicFeature	Erythema migrans	An expanding erythematous (red) skin lesion, usually round or oval, by definition at least 5 cm in size (in largest diameter).		hp.json	Erythema chronicum migrans	http://purl.obolibrary.org/obo/HP_0031180		
GO:0046483	biolink:BiologicalProcess	heterocycle metabolic process	The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).		hp.json	heterocycle metabolism	http://purl.obolibrary.org/obo/GO_0046483		goslim_pir
HP:0031181	biolink:PhenotypicFeature	Necrolytic migratory erythema	Acral or periorificial lesions that evolve in recurrent crops, with an annular and migratory distribution.		hp.json		http://purl.obolibrary.org/obo/HP_0031181		
HP:0031188	biolink:PhenotypicFeature	Genital edema	A buildup of fluid that causes swelling in the soft tissues of the genital area.		hp.json	Genital oedema	http://purl.obolibrary.org/obo/HP_0031188		
HP:0031189	biolink:PhenotypicFeature	Wrist drop	A condition in which the affected individual cannot extend the wrist, which hangs flaccidly.		hp.json		http://purl.obolibrary.org/obo/HP_0031189		
HP:0031185	biolink:PhenotypicFeature	Increased circulating NT-proBNP concentration	An elevated level of circulating N-terminal part of the prohormone of B-type natriuretic peptide (BNP).		hp.json	Increased NT-proBNP level	http://purl.obolibrary.org/obo/HP_0031185		
HP:0031186	biolink:PhenotypicFeature	Abnormal circulating deoxycorticosterone level	An abnormality of the concentration of deoxycorticosterone in the blood. Deoxycorticosterone comprises 11-deoxycorticosterone and 21-deoxycorticosterone.		hp.json		http://purl.obolibrary.org/obo/HP_0031186		
HP:0031187	biolink:PhenotypicFeature	Abnormal circulating pregnenolone concentration	An abnormality of the concentration of pregnenolone in the blood.		hp.json	Abnormality of circulating pregnenolone level	http://purl.obolibrary.org/obo/HP_0031187		
HP:0031191	biolink:PhenotypicFeature	Deep dermal perivascular inflammatory infiltrate	Numerous lymphocytes surrounding blood vessels in the deep part of the dermis.		hp.json	Deep perivascular inflammatory infiltrate	http://purl.obolibrary.org/obo/HP_0031191		
HP:0031192	biolink:PhenotypicFeature	Abnormal morphology of left ventricular trabeculae	Any structural anomaly of the muscular columns which project from the inner surface of the left ventricle of the heart (cardiac trabeculae, trabeculae carneae).		hp.json		http://purl.obolibrary.org/obo/HP_0031192		
HP:0031193	biolink:PhenotypicFeature	Abnormal morphology of right ventricular trabeculae	Any structural anomaly of the muscular columns which project from the inner surface of the right ventricle of the heart (cardiac trabeculae, trabeculae carneae).		hp.json		http://purl.obolibrary.org/obo/HP_0031193		
HP:0031194	biolink:PhenotypicFeature	Increased density of left ventricular trabeculae	An increased density (number and tightness) of the muscular columns which project from the inner surface of the left ventricles of the heart (cardiac trabeculae, trabeculae carneae).		hp.json		http://purl.obolibrary.org/obo/HP_0031194		
CHEBI:25703	biolink:ChemicalSubstance	organic phosphate		Wikipedia:Organophosphate	hp.json	organic phosphate esters|organophosphate ester|organophosphate esters|organic phosphate|organic phosphate ester|organic phosphates	http://purl.obolibrary.org/obo/CHEBI_25703		3_STAR
CHEBI:25701	biolink:ChemicalSubstance	organic oxide	An oxide in which the oxygen atom is bonded to a carbon atom.		hp.json	organic oxides	http://purl.obolibrary.org/obo/CHEBI_25701		3_STAR
HP:0031190	biolink:PhenotypicFeature	Superficial dermal perivascular inflammatory infiltrate	Numerous lymphocytes surrounding blood vessels in the superfical part of the dermis.		hp.json	Superficial perivascular inflammatory infiltrate	http://purl.obolibrary.org/obo/HP_0031190		
HP:0031199	biolink:PhenotypicFeature	Acellular urinary casts	A type of urinary cast composed of a proteinaceous matrix without a substantial number of cells.		hp.json	Acellular casts	http://purl.obolibrary.org/obo/HP_0031199		
HP:0031195	biolink:PhenotypicFeature	Apical hypertrabeculation of the left ventricle	An increased number and density of the trabeculae in the apex (tip) of the left ventricle.		hp.json		http://purl.obolibrary.org/obo/HP_0031195		
HP:0031196	biolink:PhenotypicFeature	Thin myocardium compact layer	Reduced thickness of the outer, dense layer of the myocardium.		hp.json		http://purl.obolibrary.org/obo/HP_0031196		
HP:0031197	biolink:PhenotypicFeature	Cellular urinary casts	A type of urinary cast composed of cells incorporated in a protein matrix. The cells can be those found in the urinary sediment (erythrocytes, leuklocytes, renal tubular epithelial cells).		hp.json	Cellular casts	http://purl.obolibrary.org/obo/HP_0031197		
HP:0031198	biolink:PhenotypicFeature	Renal tubular epithelial cell casts	A type of cellular urinary cast composed of renal tubular epithelial cells.		hp.json		http://purl.obolibrary.org/obo/HP_0031198		
CHEBI:25704	biolink:ChemicalSubstance	organic sulfate	Compounds of the general formula SO3HOR where R is an organyl group		hp.json	organic sulfates	http://purl.obolibrary.org/obo/CHEBI_25704		3_STAR
OIO:hasExactSynonym	biolink:NamedThing	has_exact_synonym			hp.json		http://www.geneontology.org/formats/oboInOwl#hasExactSynonym		
CHEBI:84087	biolink:ChemicalSubstance	human urinary metabolite	Any metabolite (endogenous or exogenous) found in human urine samples.		hp.json	human urinary metabolites	http://purl.obolibrary.org/obo/CHEBI_84087		3_STAR
HP:0100006	biolink:PhenotypicFeature	Neoplasm of the central nervous system	A neoplasm of the central nervous system.	SNOMEDCT_US:126951006|UMLS:C0085136|MSH:D016543|NCIT:C3262	hp.json	Neoplasia of the central nervous system|Tumors of the central nervous system|Tumours of the central nervous system|Neoplasm of the CNS	http://purl.obolibrary.org/obo/HP_0100006		
UBERON:0004819	biolink:AnatomicalEntity	kidney epithelium	The cellular avascular layer of the kidney luminar surfaces.	CALOHA:TS-0505|BTO:0000059|EMAPA:35457|MA:0002846	hp.json	epithelium of kidney|renal epithelium|kidney epithelial tissue|epithelial tissue of kidney	http://purl.obolibrary.org/obo/UBERON_0004819		pheno_slim
HP:0100007	biolink:PhenotypicFeature	Neoplasm of the peripheral nervous system	A benign or malignant neoplasm (tumour) of the peripheral nervous system.	SNOMEDCT_US:126980002|NCIT:C3262|MSH:D010524|UMLS:C0031118	hp.json	Tumor of the peripheral nervous system|Tumour of the peripheral nervous system	http://purl.obolibrary.org/obo/HP_0100007		
HP:0100004	biolink:PhenotypicFeature	Pericardial mesothelioma	A Malignant mesothelioma originating from cells of the pericardium (the thin layer of mesothelium lining the heart).	NCIT:C3234|UMLS:C1335381	hp.json		http://purl.obolibrary.org/obo/HP_0100004		
UBERON:0004817	biolink:AnatomicalEntity	lacrimal gland epithelium	An epithelium that is part of a lacrimal gland [Automatically generated definition].	MA:0001297|EMAPA:36515	hp.json	epithelial tissue of lacrimal gland|epithelium of lacrimal gland|lacrimal gland epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0004817		
HP:0100005	biolink:PhenotypicFeature	Testicular mesothelioma	A Malignant mesothelioma of the testis.	NCIT:C3234|UMLS:C4022391	hp.json		http://purl.obolibrary.org/obo/HP_0100005		
UBERON:0004815	biolink:AnatomicalEntity	lower respiratory tract epithelium	An epithelium that is part of a lower respiratory tract [Automatically generated definition].	MA:0001481|EMAPA:37549	hp.json	epithelial tissue of lower respiratory tract|lower respiratory tract epithelial tissue|epithelium of lower respiratory tract	http://purl.obolibrary.org/obo/UBERON_0004815		
HP:0100002	biolink:PhenotypicFeature	Pleural mesothelioma	A malignant mesothelioma originating from cells of the pleura (the thin layer of mesothelium lining the lungs). Pleural mesothelioma is the most common form of mesothelioma.	NCIT:C3234|SNOMEDCT_US:254645002|UMLS:C0812413	hp.json		http://purl.obolibrary.org/obo/HP_0100002		
HP:0100003	biolink:PhenotypicFeature	Peritoneal mesothelioma	A Malignant mesothelioma originating from cells of the peritoneum (the thin layer of mesothelium lining the abdomen). Peritoneal mesothelioma is the second most common form of mesothelioma after pleural mesothelioma.	UMLS:C0346109|NCIT:C3234|SNOMEDCT_US:109853004	hp.json		http://purl.obolibrary.org/obo/HP_0100003		
UBERON:0004816	biolink:AnatomicalEntity	larynx epithelium	An epithelium that is part of a larynx [Automatically generated definition].	UMLS:C0751258|NCIT:C49247|EHDAA2:0004065|MA:0001765|EMAPA:35472	hp.json	epithelial tissue of larynx|epithelium of larynx|larynx epithelial tissue|laryngeal epithelium	http://purl.obolibrary.org/obo/UBERON_0004816		pheno_slim
UBERON:0004813	biolink:AnatomicalEntity	seminiferous tubule epithelium	The stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule.	BTO:0001811|EHDAA:8148|MESH:D012670|CALOHA:TS-0920|MA:0001748|VHOG:0000631|RETIRED_EHDAA2:0002009|UMLS:C0036629|NCIT:C49296|EMAPA:35761|GAID:401|FMA:19885	hp.json	epithelium of seminiferous tubule|testis germinal epithelium|epithelial tissue of seminiferous tubule|male germinal epithelium|seminiferous tubule epithelial tissue|wall of seminiferous tubule|epithelium of seminiferous tubule of testis|germinal epithelium (male)|seminiferous epithelium|epithelial tissue of seminiferous tubule of testis	http://purl.obolibrary.org/obo/UBERON_0004813		pheno_slim
HP:0100000	biolink:PhenotypicFeature	Early onset of sexual maturation	An early onset of puberty, in this case early does not refer to precocious.	UMLS:C4022392	hp.json	Early onset of sexual maturation	http://purl.obolibrary.org/obo/HP_0100000		
HP:0100001	biolink:PhenotypicFeature	Malignant mesothelioma	Malignant mesothelioma is a form of cancer that originates from the cells of the mesothelium, a thin tissue layer surrounding the body's internal organs. Malignant mesothelioma is almost exclusively caused by asbestos exposure, pleural mesothelioma beeing the most common form, affecting the lining of the lungs called the pleura. Other forms such as perioneal-, percardial- or testicular- mesothelioma are much rarer.	UMLS:C0345967|SNOMEDCT_US:62064005|MSH:C562839	hp.json		http://purl.obolibrary.org/obo/HP_0100001		
UBERON:0004814	biolink:AnatomicalEntity	upper respiratory tract epithelium	An epithelium that is part of a upper respiratory tract [Automatically generated definition].	MA:0001912|EMAPA:35894	hp.json	upper respiratory tract epithelial tissue|epithelium of upper respiratory tract|epithelial tissue of upper respiratory tract	http://purl.obolibrary.org/obo/UBERON_0004814		
GO:0034613	biolink:BiologicalProcess	cellular protein localization	Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.		hp.json	channel localizer activity|cellular protein localisation	http://purl.obolibrary.org/obo/GO_0034613		
GO:0010646	biolink:BiologicalProcess	regulation of cell communication	Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.		hp.json		http://purl.obolibrary.org/obo/GO_0010646		
GO:0010647	biolink:BiologicalProcess	positive regulation of cell communication	Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.		hp.json		http://purl.obolibrary.org/obo/GO_0010647		
GO:0010648	biolink:BiologicalProcess	negative regulation of cell communication	Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.		hp.json		http://purl.obolibrary.org/obo/GO_0010648		
GO:0009653	biolink:BiologicalProcess	anatomical structure morphogenesis	The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.	Wikipedia:Morphogenesis	hp.json	morphogenesis|anatomical structure organization|embryogenesis and morphogenesis	http://purl.obolibrary.org/obo/GO_0009653		
HP:0041181	biolink:PhenotypicFeature	Fractured distal phalanx of pedal digit 3	A partial or complete breakage of the distal phalanx of pedal digit 3.		hp.json	bone distal phalanx of pedal digit 3	http://purl.obolibrary.org/obo/HP_0041181		
HP:0041182	biolink:PhenotypicFeature	Fractured middle phalanx of manual digit 2	A partial or complete breakage of the middle phalanx of manual digit 2.		hp.json	bone middle phalanx of manual digit 2	http://purl.obolibrary.org/obo/HP_0041182		
HP:0041180	biolink:PhenotypicFeature	Fractured distal phalanx of pedal digit 1	A partial or complete breakage of the distal phalanx of pedal digit 1.		hp.json	bone distal phalanx of pedal digit 1	http://purl.obolibrary.org/obo/HP_0041180		
UBERON:0004822	biolink:AnatomicalEntity	extrahepatic bile duct epithelium	An epithelium that is part of a extrahepatic bile duct [Automatically generated definition].	UMLS:C1711347|NCIT:C43618|EHDAA:3051|EHDAA2:0000742|MA:0002661	hp.json	epithelial tissue of extrahepatic bile duct|epithelium of extrahepatic bile duct|extrahepatic bile duct epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0004822		
HP:0041185	biolink:PhenotypicFeature	Fractured middle phalanx of manual digit 5	A partial or complete breakage of the middle phalanx of manual digit 5.		hp.json	bone middle phalanx of manual digit 5	http://purl.obolibrary.org/obo/HP_0041185		
UBERON:0004823	biolink:AnatomicalEntity	intrahepatic bile duct epithelium	An epithelium that is part of a intrahepatic bile duct [Automatically generated definition].	EHDAA:3053|NCIT:C43617|UMLS:C1708552|EHDAA2:0000743|MA:0002662	hp.json	epithelial tissue of intrahepatic bile duct|epithelium of intrahepatic bile duct|intrahepatic bile duct epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0004823		
HP:0041186	biolink:PhenotypicFeature	Fractured middle phalanx of pedal digit 3	A partial or complete breakage of the middle phalanx of pedal digit 3.		hp.json	bone middle phalanx of pedal digit 3	http://purl.obolibrary.org/obo/HP_0041186		
UBERON:0004820	biolink:AnatomicalEntity	bile duct epithelium	Any epithelium that lines one of the bile ducts.	MA:0001629|NCIT:C43616|UMLS:C1711208|BTO:0000417	hp.json	epithelium of bile duct|epithelium of biliary duct|biliary duct epithelium	http://purl.obolibrary.org/obo/UBERON_0004820		pheno_slim
HP:0041183	biolink:PhenotypicFeature	Fractured middle phalanx of manual digit 3	A partial or complete breakage of the middle phalanx of manual digit 3.		hp.json	bone middle phalanx of manual digit 3	http://purl.obolibrary.org/obo/HP_0041183		
UBERON:0004821	biolink:AnatomicalEntity	pulmonary alveolus epithelium	The epithelial layer of the alveoli[MP]. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles[BTO].	BTO:0003511|FMA:63915|NCIT:C12867|EMAPA:35121|MA:0001771	hp.json	epithelial tissue of alveolus|epithelium of alveolus|pulmonary alveolus epithelium|pulmonary alveolar epithelium|epithelium of pulmonary alveolus|alveolus epithelial tissue|alveolar epithelium|alveolus epithelium	http://purl.obolibrary.org/obo/UBERON_0004821		pheno_slim
HP:0041184	biolink:PhenotypicFeature	Fractured middle phalanx of manual digit 4	A partial or complete breakage of the middle phalanx of manual digit 4.		hp.json	bone middle phalanx of manual digit 4	http://purl.obolibrary.org/obo/HP_0041184		
HP:0041189	biolink:PhenotypicFeature	Fractured epiphysis of femur	A partial or complete breakage of the epiphysis of femur.		hp.json	bone epiphysis of femur	http://purl.obolibrary.org/obo/HP_0041189		
HP:0100008	biolink:PhenotypicFeature	Schwannoma	A benign nerve sheath tumor composed of Schwann cells.	MSH:D009442|SNOMEDCT_US:985004|UMLS:C0027809|SNOMEDCT_US:404022001	hp.json	Schwann cell tumour|Neurolemmoma|Schwann cell tumor|Schwannomas|Neurinoma|Neurilemmoma	http://purl.obolibrary.org/obo/HP_0100008		
HP:0041187	biolink:PhenotypicFeature	Fractured proximal phalanx of pedal digit 1	A partial or complete breakage of the proximal phalanx of pedal digit 1.		hp.json	bone proximal phalanx of pedal digit 1	http://purl.obolibrary.org/obo/HP_0041187		
HP:0100009	biolink:PhenotypicFeature	Intracranial meningioma		SNOMEDCT_US:302820008|MSH:D008579|UMLS:C0349604	hp.json		http://purl.obolibrary.org/obo/HP_0100009		
HP:0041188	biolink:PhenotypicFeature	Fractured proximal phalanx of manual digit 1	A partial or complete breakage of the proximal phalanx of manual digit 1.		hp.json	bone proximal phalanx of manual digit 1	http://purl.obolibrary.org/obo/HP_0041188		
HP:0100017	biolink:PhenotypicFeature	Capsular cataract	A cataract that affects the capsule of the lens.	SNOMEDCT_US:204125003|UMLS:C0339352	hp.json		http://purl.obolibrary.org/obo/HP_0100017		
UBERON:0004808	biolink:AnatomicalEntity	gastrointestinal system epithelium	An epithelium that is part of a digestive system [Automatically generated definition].	MA:0001520|EMAPA:32683	hp.json	epithelium of gastrointestinal system|epithelial tissue of digestive system|epithelial tissue of gastrointestinal system|digestive system epithelium|epithelium of digestive system|gastrointestinal system epithelial tissue|digestive system epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0004808		
UBERON:0004809	biolink:AnatomicalEntity	salivary gland epithelium	An epithelium that is part of a salivary gland [Automatically generated definition].	EMAPA:32816|MA:0001587|CALOHA:TS-2067|BTO:0004421	hp.json	salivary gland epithelial tissue|epithelial tissue of salivary gland|epithelium of salivary gland	http://purl.obolibrary.org/obo/UBERON_0004809		pheno_slim
HP:0100018	biolink:PhenotypicFeature	Nuclear cataract	A nuclear cataract is an opacity or clouding that develops in the lens nucleus. That is, a nuclear cataract is one that is located in the center of the lens. The nucleus tends to darken changing from clear to yellow and sometimes brown.	UMLS:C0392557|SNOMEDCT_US:53889007	hp.json	Yellowish cloudy center of lens|Yellowish cloudy centre of lens	http://purl.obolibrary.org/obo/HP_0100018		hposlim_core
UBERON:0004806	biolink:AnatomicalEntity	vas deferens epithelium	An epithelium that is part of a vas deferens [Automatically generated definition].	UMLS:C1710617|NCIT:C49315|EMAPA:29274|MA:0001749|FMA:225317	hp.json	vas deferen epithelial tissue|vas deferens epithelial tissue|sperm duct epithelial tissue|sperm duct epithelium|epithelium of deferent duct|epithelium of ductus deferens|epithelial tissue of deferent duct|epithelial tissue of ductus deferens|vas deferen epithelium|epithelial tissue of vas deferens|deferent duct epithelial tissue|epithelial tissue of sperm duct|epithelium of vas deferen|ductus deferens epithelial tissue|epithelium of vas deferens|epithelial tissue of vas deferen|ductus deferens epithelium|epithelium of sperm duct|deferent duct epithelium	http://purl.obolibrary.org/obo/UBERON_0004806		
HP:0100015	biolink:PhenotypicFeature	Stahl ear	The presence of a supernumerary, i.e. third, crus of the helix in the helix, arising at or above the normal bifurcation of the antihelix.	UMLS:C1862689|SNOMEDCT_US:253252004	hp.json	Additional crus|Third crus	http://purl.obolibrary.org/obo/HP_0100015		
UBERON:0004807	biolink:AnatomicalEntity	respiratory system epithelium	An epithelium that is part of a respiratory system [Automatically generated definition].	EMAPA:32826|MA:0001823|VHOG:0000981|CALOHA:TS-0023	hp.json	apparatus respiratorius epithelium|epithelium of apparatus respiratorius|epithelial tissue of apparatus respiratorius|epithelial tissue of respiratory system|epithelium of respiratory system|apparatus respiratorius epithelial tissue|respiratory system epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0004807		pheno_slim
HP:0100016	biolink:PhenotypicFeature	Abnormality of mesentery morphology	Folds of membranous tissue (peritoneum, mesothelium) attached to the wall of the abdomen and enclosing viscera. Examples include the mesentery for the small intestine; the transverse mesocolon, which attaches the transverse portion of the colon to the back wall of the abdomen; and the mesosigmoid, which enfolds the sigmoid portion of the colon. Cells of the same embryologic origin also surround the other organs of the body such as the lungs (pleura) or the heart (pericardium).	UMLS:C4022389	hp.json	Abnormality of the mesentery	http://purl.obolibrary.org/obo/HP_0100016		
HP:0100013	biolink:PhenotypicFeature	Neoplasm of the breast	A tumor (abnormal growth of tissue) of the breast.	SNOMEDCT_US:126926005|NCIT:C3262|MSH:D001943|UMLS:C1458155	hp.json	Tumours of the breast|Neoplasia of the breast|Breast tumor|Breast tumour	http://purl.obolibrary.org/obo/HP_0100013		
UBERON:0004804	biolink:AnatomicalEntity	oviduct epithelium	An epithelium that is part of a oviduct [Automatically generated definition].	EMAPA:29043|BTO:0002402|MA:0001718|CALOHA:TS-1316	hp.json	epithelium of fallopian tube|epithelium of uterine tube|columnar epithelium of the fallopian tube|fallopian tube epithelium|epithelium of oviduct|epithelial tissue of oviduct|columnar epithelium of the oviduct|oviduct epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0004804		human_reference_atlas
GO:0007009	biolink:BiologicalProcess	plasma membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.		hp.json	plasma membrane organization and biogenesis|plasma membrane organisation	http://purl.obolibrary.org/obo/GO_0007009		goslim_chembl
HP:0100014	biolink:PhenotypicFeature	Epiretinal membrane	An epiretinal membrane is a thin sheet of fibrous tissue that can develop on the surface of the macular area of the retina and cause a disturbance in vision. An epiretinal membrane area can develop on the thin macular area of the retin. An epiretinal membrane is also sometimes called a macular pucker, premacular fibrosis, surface wrinkling retinopathy or cellophane maculopathy.	SNOMEDCT_US:133853005|MSH:D019773|SNOMEDCT_US:367649002|UMLS:C0339543	hp.json	Epiretinal membranes|Premacular fibrosis|Macular pucker	http://purl.obolibrary.org/obo/HP_0100014		
UBERON:0004805	biolink:AnatomicalEntity	seminal vesicle epithelium	An epithelium that is part of a seminal vesicle [Automatically generated definition].	EMAPA:29771|UMLS:C1710049|MA:0001745|NCIT:C49295|CALOHA:TS-2069	hp.json	epithelium of seminal gland|seminal vesicle epithelial tissue|seminal gland epithelium|epithelial tissue of seminal gland|seminal gland epithelial tissue|epithelium of seminal vesicle|epithelial tissue of seminal vesicle	http://purl.obolibrary.org/obo/UBERON_0004805		
HP:0100011	biolink:PhenotypicFeature	Scleral schwannoma		NCIT:C3269|UMLS:C4022390	hp.json		http://purl.obolibrary.org/obo/HP_0100011		
UBERON:0004802	biolink:AnatomicalEntity	respiratory tract epithelium	The pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi.	MA:0001480|SCTID:321764001|VHOG:0000981|BTO:0000419|CALOHA:TS-0023|EMAPA:32827	hp.json	respiratory epithelium|epithelial tissue of respiratory tract|respiratory tract epithelial tissue|airway epithelium|epithelium of respiratory tract	http://purl.obolibrary.org/obo/UBERON_0004802		pheno_slim
HP:0100012	biolink:PhenotypicFeature	Neoplasm of the eye	A tumor (abnormal growth of tissue) of the eye.	UMLS:C0015414|MSH:D005134|SNOMEDCT_US:371486001|NCIT:C3262	hp.json	Eye tumor|Neoplasia of the eye|Eye tumour	http://purl.obolibrary.org/obo/HP_0100012		
UBERON:0004803	biolink:AnatomicalEntity	penis epithelium	An epithelium that is part of a penis [Automatically generated definition].	EHDAA2:0004039|EMAPA:35674|MA:0001742	hp.json	penis epithelial tissue|epithelium of penis|epithelial tissue of penis	http://purl.obolibrary.org/obo/UBERON_0004803		
GO:0007006	biolink:BiologicalProcess	mitochondrial membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.		hp.json	mitochondrial membrane organisation|mitochondrial membrane organization and biogenesis	http://purl.obolibrary.org/obo/GO_0007006		
GO:0007005	biolink:BiologicalProcess	mitochondrion organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.		hp.json	mitochondrion organization and biogenesis|mitochondria organization|mitochondrion organisation	http://purl.obolibrary.org/obo/GO_0007005		goslim_drosophila|goslim_chembl|goslim_generic|goslim_yeast|goslim_pombe|goslim_pir
GO:0010657	biolink:BiologicalProcess	muscle cell apoptotic process	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle.		hp.json	muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010657		
HP:0100010	biolink:PhenotypicFeature	Spinal meningioma		MSH:D008579|UMLS:C0347515|NCIT:C3230|SNOMEDCT_US:189167009	hp.json		http://purl.obolibrary.org/obo/HP_0100010		
GO:0010658	biolink:BiologicalProcess	striated muscle cell apoptotic process	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations.		hp.json	striated muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010658		
GO:0010656	biolink:BiologicalProcess	negative regulation of muscle cell apoptotic process	Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.		hp.json	negative regulation of muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010656		
GO:0007000	biolink:BiologicalProcess	nucleolus organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus.		hp.json	nucleolus organization and biogenesis|nucleolus organisation	http://purl.obolibrary.org/obo/GO_0007000		
GO:0010659	biolink:BiologicalProcess	cardiac muscle cell apoptotic process	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.		hp.json	cardiac muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010659		
HP:0041192	biolink:PhenotypicFeature	Fractured epiphysis of fourth metacarpal bone	A partial or complete breakage of the epiphysis of fourth metacarpal bone.		hp.json	bone epiphysis of fourth metacarpal bone	http://purl.obolibrary.org/obo/HP_0041192		
HP:0041193	biolink:PhenotypicFeature	Fractured epiphysis of first metatarsal bone	A partial or complete breakage of the epiphysis of first metatarsal bone.		hp.json	bone epiphysis of first metatarsal bone	http://purl.obolibrary.org/obo/HP_0041193		
HP:0041190	biolink:PhenotypicFeature	Fractured epiphysis of second metacarpal bone	A partial or complete breakage of the epiphysis of second metacarpal bone.		hp.json	bone epiphysis of second metacarpal bone	http://purl.obolibrary.org/obo/HP_0041190		
HP:0041191	biolink:PhenotypicFeature	Fractured epiphysis of third metacarpal bone	A partial or complete breakage of the epiphysis of third metacarpal bone.		hp.json	bone epiphysis of third metacarpal bone	http://purl.obolibrary.org/obo/HP_0041191		
UBERON:0004811	biolink:AnatomicalEntity	endometrium epithelium	An epithelium that is part of an endometrium [Automatically generated definition].	EMAPA:35307|SCTID:253526009|MA:0002731	hp.json	uterine epithelium|uterine epithelium|epithelium of tunica mucosa of endometrium|epithelium of endometrium|epithelial tissue of endometrium|endometrium epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0004811		pheno_slim
HP:0041196	biolink:PhenotypicFeature	Fractured distal epiphysis of radius	A partial or complete breakage of the distal epiphysis of radius.		hp.json	bone distal epiphysis of radius	http://purl.obolibrary.org/obo/HP_0041196		
UBERON:0004812	biolink:AnatomicalEntity	male prepuce epithelium	An epithelium that is part of a prepuce of penis [Automatically generated definition].	EMAPA:30655|UMLS:C1709639|MA:0001753|NCIT:C49270	hp.json	epithelium of foreskin|prepuce of penis epithelial tissue|prepuce epithelial tissue|epithelial tissue of penile prepuce|penile prepuce epithelium|epithelium of penile prepuce|foreskin epithelial tissue|epithelial tissue of prepuce of penis|epithelium of prepuce of penis|prepuce epithelium|foreskin epithelium|epithelium of prepuce|penile prepuce epithelial tissue|prepuce of penis epithelium|epithelial tissue of foreskin|epithelial tissue of prepuce	http://purl.obolibrary.org/obo/UBERON_0004812		
HP:0041197	biolink:PhenotypicFeature	Fractured proximal epiphysis of first metacarpal bone	A partial or complete breakage of the proximal epiphysis of first metacarpal bone.		hp.json	bone proximal epiphysis of first metacarpal bone	http://purl.obolibrary.org/obo/HP_0041197		
HP:0041194	biolink:PhenotypicFeature	Fractured epiphysis of second metatarsal bone	A partial or complete breakage of the epiphysis of second metatarsal bone.		hp.json	bone epiphysis of second metatarsal bone	http://purl.obolibrary.org/obo/HP_0041194		
UBERON:0004810	biolink:AnatomicalEntity	nephron tubule epithelium	The cellular avascular layer of the renal tubule luminar surfaces.	MA:0001681|UMLS:C1709902|BTO:0005239|EMAPA:36524|NCIT:C49276	hp.json	kidney tubule epithelium	http://purl.obolibrary.org/obo/UBERON_0004810		pheno_slim
HP:0041195	biolink:PhenotypicFeature	Fractured epiphysis of third metatarsal bone	A partial or complete breakage of the epiphysis of third metatarsal bone.		hp.json	bone epiphysis of third metatarsal bone	http://purl.obolibrary.org/obo/HP_0041195		
HP:0041198	biolink:PhenotypicFeature	Fractured proximal epiphysis of middle phalanx of manual digit 3	A partial or complete breakage of the proximal epiphysis of middle phalanx of manual digit 3.		hp.json	bone proximal epiphysis of middle phalanx of manual digit 3	http://purl.obolibrary.org/obo/HP_0041198		
HP:0100019	biolink:PhenotypicFeature	Cortical cataract	A cataract which affects the layer of the lens surrounding the nucleus, i.e., the lens cortex. It is identified by its unique wedge or spoke appearance.	UMLS:C0271160|SNOMEDCT_US:193576003	hp.json		http://purl.obolibrary.org/obo/HP_0100019		hposlim_core
HP:0041199	biolink:PhenotypicFeature	Fractured interphalangeal joint	A partial or complete breakage of the interphalangeal joint.		hp.json	bone interphalangeal joint	http://purl.obolibrary.org/obo/HP_0041199		
HP:0100028	biolink:PhenotypicFeature	Ectopic thyroid	Mislocalised thyroid gland.	UMLS:C0266283|MSH:D050033|SNOMEDCT_US:214660000	hp.json	Aberrant thyroid gland|Ectopic thyroid gland|Heteropic thyroid gland|Abnormal thryoid location|Aberrant thyroid	http://purl.obolibrary.org/obo/HP_0100028		
HP:0100029	biolink:PhenotypicFeature	Lingual thyroid	An aberrant thyroid gland or Ectopic thyroid located at the base of the tongue, just posterior to the foramen cecum as a result of a failure of the thyroid to descend.	SNOMEDCT_US:21279007|MSH:D046151|UMLS:C0266284|SNOMEDCT_US:129123002	hp.json		http://purl.obolibrary.org/obo/HP_0100029		
HP:0100026	biolink:PhenotypicFeature	Arteriovenous malformation	An anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries.	MSH:D001165|SNOMEDCT_US:24551003|SNOMEDCT_US:234141001|UMLS:C0003857	hp.json		http://purl.obolibrary.org/obo/HP_0100026		
HP:0100027	biolink:PhenotypicFeature	Recurrent pancreatitis	A recurrent form of pancreatitis.	SNOMEDCT_US:233870001|MSH:D050500|UMLS:C0149521|SNOMEDCT_US:235494005|SNOMEDCT_US:234689009	hp.json	Recurring pancreas inflammation|Recurring pancreatitis	http://purl.obolibrary.org/obo/HP_0100027		
HP:0100024	biolink:PhenotypicFeature	Conspicuously happy disposition	An unusually happy aspect over time which can also may be observed during inappropriate situations that should be causing for example distress, fear or anger.	UMLS:C4021029	hp.json	Conspicious happy aspect|Happy aspect	http://purl.obolibrary.org/obo/HP_0100024		
HP:0100025	biolink:PhenotypicFeature	Overfriendliness	A form of hypersociability that presents as mostly inappropriate people-orientation and friendliness towards others on an inadequate level which might go as far as being dangerous considering for example young children following strangers without restriction.	UMLS:C4022386	hp.json	Overfriendliness	http://purl.obolibrary.org/obo/HP_0100025		
HP:0100022	biolink:PhenotypicFeature	Abnormality of movement	An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements.	MSH:D009069|UMLS:C0026650|SNOMEDCT_US:60342002	hp.json	Unusual movement|Movement disorder|Abnormality of movement	http://purl.obolibrary.org/obo/HP_0100022		
HP:0100023	biolink:PhenotypicFeature	Recurrent hand flapping	A type of stereotypic behavior in which the affected individual repeatedly waves the hands up and down.	UMLS:C4022387	hp.json		http://purl.obolibrary.org/obo/HP_0100023		
GO:0022610	biolink:NamedThing	biological adhesion			hp.json		http://purl.obolibrary.org/obo/GO_0022610		
GO:0010624	biolink:BiologicalProcess	regulation of Schwann cell proliferation	Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0010624		
HP:0100020	biolink:PhenotypicFeature	Posterior capsular cataract	A cataract which is found in the back outer layer of the lens. This type often develops more rapidly.	UMLS:C4022388	hp.json		http://purl.obolibrary.org/obo/HP_0100020		
GO:0010625	biolink:BiologicalProcess	positive regulation of Schwann cell proliferation	Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0010625		
HP:0100021	biolink:PhenotypicFeature	Cerebral palsy	Cerebral palsy describes a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to nonprogressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, and behaviour, by epilepsy, and by secondary musculoskeletal problems.	UMLS:C0007789|MSH:D002547|SNOMEDCT_US:128188000	hp.json	CP|Cerebral paralysis	http://purl.obolibrary.org/obo/HP_0100021		
GO:0046622	biolink:BiologicalProcess	positive regulation of organ growth	Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.		hp.json		http://purl.obolibrary.org/obo/GO_0046622		
GO:0010623	biolink:BiologicalProcess	programmed cell death involved in cell development	The activation of endogenous cellular processes that result in the death of a cell as part of its development.		hp.json	programmed cell death involved in development|developmental programmed cell death	http://purl.obolibrary.org/obo/GO_0010623		
GO:0046621	biolink:BiologicalProcess	negative regulation of organ growth	Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.		hp.json		http://purl.obolibrary.org/obo/GO_0046621		
GO:0046620	biolink:BiologicalProcess	regulation of organ growth	Any process that modulates the frequency, rate or extent of growth of an organ of an organism.		hp.json		http://purl.obolibrary.org/obo/GO_0046620		
GO:0010628	biolink:BiologicalProcess	positive regulation of gene expression	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).		hp.json		http://purl.obolibrary.org/obo/GO_0010628		
GO:0010629	biolink:BiologicalProcess	negative regulation of gene expression	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).		hp.json	gene silencing	http://purl.obolibrary.org/obo/GO_0010629		
GO:0010626	biolink:BiologicalProcess	negative regulation of Schwann cell proliferation	Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.		hp.json		http://purl.obolibrary.org/obo/GO_0010626		
NBO:0000280	biolink:NamedThing	attraction-related behavior			hp.json		http://purl.obolibrary.org/obo/NBO_0000280		
GO:0022613	biolink:BiologicalProcess	ribonucleoprotein complex biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.		hp.json	ribonucleoprotein complex biogenesis and assembly|RNA-protein complex biogenesis	http://purl.obolibrary.org/obo/GO_0022613		
GO:0022612	biolink:BiologicalProcess	gland morphogenesis	The process in which the anatomical structures of a gland are generated and organized.		hp.json		http://purl.obolibrary.org/obo/GO_0022612		
UBERON:0004801	biolink:AnatomicalEntity	cervix epithelium	An epithelium that is part of a uterine cervix [Automatically generated definition].	NCIT:C49218|UMLS:C1711358|EMAPA:29929|CALOHA:TS-0137|MA:0001724|BTO:0000241|EFO:0001913	hp.json	cervical epithelium|epithelium of cervix|cervical canal epithelium|cervical canal epithelial tissue|cervix epithelial tissue	http://purl.obolibrary.org/obo/UBERON_0004801		pheno_slim|efo_slim|human_reference_atlas
CHEBI:33290	biolink:ChemicalSubstance	food	Any material that can be ingested by an organism.		hp.json	foodstuffs|food materials|food material|food role|foodstuff|foods	http://purl.obolibrary.org/obo/CHEBI_33290		3_STAR
GO:0009636	biolink:BiologicalProcess	response to toxic substance	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.		hp.json	detoxification response|toxin resistance|toxin susceptibility/resistance	http://purl.obolibrary.org/obo/GO_0009636		goslim_chembl
CHEBI:33292	biolink:ChemicalSubstance	fuel	An energy-rich substance that can be transformed with release of usable energy.		hp.json		http://purl.obolibrary.org/obo/CHEBI_33292		3_STAR
GO:0022617	biolink:BiologicalProcess	extracellular matrix disassembly	A process that results in the breakdown of the extracellular matrix.		hp.json		http://purl.obolibrary.org/obo/GO_0022617		
CHEBI:33295	biolink:ChemicalSubstance	diagnostic agent	A substance administered to aid diagnosis of a disease.		hp.json	diagnostic aid	http://purl.obolibrary.org/obo/CHEBI_33295		3_STAR
GO:0022618	biolink:BiologicalProcess	ribonucleoprotein complex assembly	The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.		hp.json	RNP complex assembly|RNA-protein complex assembly|protein-RNA complex assembly	http://purl.obolibrary.org/obo/GO_0022618		goslim_chembl
CHEBI:33296	biolink:ChemicalSubstance	alkali metal molecular entity	A molecular entity containing one or more atoms of an alkali metal.		hp.json	alkali metal molecular entities	http://purl.obolibrary.org/obo/CHEBI_33296		3_STAR
HP:0100039	biolink:PhenotypicFeature	Thickened cortex of bones	An Abnormality of cortical bone leading to an abnormal thickness of the cortex of affected bones.	UMLS:C4022382	hp.json		http://purl.obolibrary.org/obo/HP_0100039		
HP:0100037	biolink:PhenotypicFeature	Abnormality of the scalp hair	An abnormality of the hair of head.	UMLS:C4022384	hp.json	Abnormality of the scalp hair	http://purl.obolibrary.org/obo/HP_0100037		
HP:0100038	biolink:PhenotypicFeature	Slow-growing scalp hair	Scalp hair whose growth is slower than normal.	UMLS:C4022383	hp.json	Slow-growing scalp hair	http://purl.obolibrary.org/obo/HP_0100038		
HP:0100035	biolink:PhenotypicFeature	Phonic tics	Involuntary sounds produced by moving air through the nose, mouth, or throat. The vocal cords are not involved in all tics that produce sound.	MSH:D020323|UMLS:C0751901	hp.json	Verbal tics|Vocal tics	http://purl.obolibrary.org/obo/HP_0100035		
HP:0100036	biolink:PhenotypicFeature	Pseudo-fractures	A band of bone material of decreased density forming alongside the surface of the cortical bone with thickening of the periosteum. Callus formation in the affected area is common and gives the appearance of a false fracture.	UMLS:C4021028	hp.json	Looser zones	http://purl.obolibrary.org/obo/HP_0100036		
GO:0022600	biolink:BiologicalProcess	digestive system process	A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.		hp.json		http://purl.obolibrary.org/obo/GO_0022600		goslim_generic
HP:0100033	biolink:PhenotypicFeature	Tics	Repeated, individually recognizable, intermittent movements or movement fragments that are almost always briefly suppresable and are usually associated with awareness of an urge to perform the movement.	UMLS:C2169806	hp.json	Tic disorder|Tics	http://purl.obolibrary.org/obo/HP_0100033		
HP:0100034	biolink:PhenotypicFeature	Motor tics	Movement-based tics affecting discrete muscle groups.	MSH:D020323|UMLS:C0751900	hp.json		http://purl.obolibrary.org/obo/HP_0100034		
HP:0100031	biolink:PhenotypicFeature	Neoplasm of the thyroid gland	A tumor (abnormal growth of tissue) of the thyroid gland.	NCIT:C3262|MSH:D013964|SNOMEDCT_US:127018007|UMLS:C0040136	hp.json	Neoplasia of the thyroid gland	http://purl.obolibrary.org/obo/HP_0100031		
GO:0010633	biolink:BiologicalProcess	negative regulation of epithelial cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0010633		
GO:0010634	biolink:BiologicalProcess	positive regulation of epithelial cell migration	Any process that activates or increases the frequency, rate or extent of epithelial cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0010634		
HP:0100030	biolink:PhenotypicFeature	Accessory ectopic thyroid tissue	Accessory ectopic thyroid tissue arising from remnants of the thyroglossal duct anywhere along the path of the thyroglossal duct tract.	UMLS:C4022385	hp.json		http://purl.obolibrary.org/obo/HP_0100030		
GO:0010639	biolink:BiologicalProcess	negative regulation of organelle organization	Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.		hp.json	negative regulation of organelle organization and biogenesis|negative regulation of organelle organisation	http://purl.obolibrary.org/obo/GO_0010639		
GO:0010638	biolink:BiologicalProcess	positive regulation of organelle organization	Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.		hp.json	positive regulation of organelle organisation|positive regulation of organelle organization and biogenesis	http://purl.obolibrary.org/obo/GO_0010638		
GO:0010631	biolink:BiologicalProcess	epithelial cell migration	The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism.		hp.json		http://purl.obolibrary.org/obo/GO_0010631		
GO:0010632	biolink:BiologicalProcess	regulation of epithelial cell migration	Any process that modulates the frequency, rate or extent of epithelial cell migration.		hp.json		http://purl.obolibrary.org/obo/GO_0010632		
GO:0022602	biolink:BiologicalProcess	ovulation cycle process	A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.		hp.json	estrous cycle process|menstrual cycle process	http://purl.obolibrary.org/obo/GO_0022602		
GO:0022601	biolink:BiologicalProcess	menstrual cycle phase	The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur.		hp.json		http://purl.obolibrary.org/obo/GO_0022601		gocheck_do_not_annotate
GO:0022604	biolink:BiologicalProcess	regulation of cell morphogenesis	Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.		hp.json	regulation of cell shape and cell size|negative regulation of cell shape and cell size|positive regulation of cell shape and cell size	http://purl.obolibrary.org/obo/GO_0022604		
GO:0022603	biolink:BiologicalProcess	regulation of anatomical structure morphogenesis	Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.		hp.json	regulation of morphogenesis	http://purl.obolibrary.org/obo/GO_0022603		
GO:0022607	biolink:BiologicalProcess	cellular component assembly	The aggregation, arrangement and bonding together of a cellular component.		hp.json	cell structure assembly|cellular component assembly at cellular level	http://purl.obolibrary.org/obo/GO_0022607		goslim_chembl|goslim_pir
HP:0041149	biolink:PhenotypicFeature	Fractured navicular bone of pes	A partial or complete breakage of the navicular bone of pes.		hp.json	bone navicular bone of pes	http://purl.obolibrary.org/obo/HP_0041149		
HP:0100048	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the 2nd toe		UMLS:C4022373	hp.json	Fragmentation of the end part of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100048		
GO:0010608	biolink:BiologicalProcess	post-transcriptional regulation of gene expression	Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.		hp.json	posttranscriptional regulation of gene expression	http://purl.obolibrary.org/obo/GO_0010608		
HP:0041147	biolink:PhenotypicFeature	Fractured epiphysis	A partial or complete breakage of the epiphysis.		hp.json	bone epiphysis	http://purl.obolibrary.org/obo/HP_0041147		
HP:0100049	biolink:PhenotypicFeature	Irregular epiphyses of the 2nd toe		UMLS:C4022372	hp.json	Irregular end part of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100049		
UBERON:0004859	biolink:AnatomicalEntity	eye gland	A gland that is part of a eye. The eye is a compound unit which depending on the species may consist of an eyeballs plus associated ducts and integumentary structures. Eye glands therefore include the various types of lacrimal gland, the various types of apocrine and sebaceous glands associated with the eyelid.	EMAPA:35334|MA:0000267	hp.json	gland of eye|eye-associated gland|eye-associated gland	http://purl.obolibrary.org/obo/UBERON_0004859		organ_slim
HP:0100046	biolink:PhenotypicFeature	Cone-shaped epiphyses of the 2nd toe		UMLS:C4022375	hp.json	Cone-shaped end part of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100046		
HP:0100047	biolink:PhenotypicFeature	Enlarged epiphyses of the 2nd toe		UMLS:C4022374	hp.json	Enlarged end part of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100047		
UBERON:0004857	biolink:AnatomicalEntity	skeletal muscle connective tissue	A connective tissue that surrounds a skeletal muscle tissue.	MA:0002868|EMAPA:37743	hp.json	skeletal muscle tissue connective tissue|skeletal muscle tissue textus connectivus|skeletal muscle interstitum|skeletal muscle portion of connective tissue|textus connectivus of skeletal muscle|portion of connective tissue of skeletal muscle tissue|connective tissue of skeletal muscle tissue|skeletal muscle interstitial tissue|skeletal muscle tissue portion of connective tissue|portion of connective tissue of skeletal muscle|connective tissue of skeletal muscle|skeletal muscle textus connectivus|textus connectivus of skeletal muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004857		
HP:0100044	biolink:PhenotypicFeature	Absent epiphyses of the 2nd toe		UMLS:C4022377	hp.json	Absent end part of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100044		
HP:0100045	biolink:PhenotypicFeature	Bracket epiphyses of the 2nd toe		UMLS:C4022376	hp.json	Bracket shaped end part of 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100045		
OIO:hasSynonymType	biolink:NamedThing	has_synonym_type			hp.json		http://www.geneontology.org/formats/oboInOwl#hasSynonymType		
HP:0100042	biolink:PhenotypicFeature	Broad 4th toe	A broad appearance of the fourth toe.	UMLS:C4022379	hp.json	Wide 4th toe|Broad 4th toe	http://purl.obolibrary.org/obo/HP_0100042		
HP:0100043	biolink:PhenotypicFeature	Broad 5th toe	A broad appearance of the fifth toe.	UMLS:C4022378	hp.json	Broad pinky toe|Broad little toe|Broad pinkie toe|Broad 5th toe	http://purl.obolibrary.org/obo/HP_0100043		
HP:0100040	biolink:PhenotypicFeature	Broad 2nd toe	A broad appearance of the second toe.	UMLS:C4022381	hp.json	Wide 2nd toe	http://purl.obolibrary.org/obo/HP_0100040		
HP:0100041	biolink:PhenotypicFeature	Broad 3rd toe	A broad appearance of the third toe.	UMLS:C4022380	hp.json	Broad 3rd toe|Wide 3rd toe	http://purl.obolibrary.org/obo/HP_0100041		
GO:0010604	biolink:BiologicalProcess	positive regulation of macromolecule metabolic process	Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.		hp.json		http://purl.obolibrary.org/obo/GO_0010604		
GO:0010605	biolink:BiologicalProcess	negative regulation of macromolecule metabolic process	Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.		hp.json		http://purl.obolibrary.org/obo/GO_0010605		
GO:0046649	biolink:BiologicalProcess	lymphocyte activation	A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor.		hp.json		http://purl.obolibrary.org/obo/GO_0046649		
GO:0009611	biolink:BiologicalProcess	response to wounding	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.		hp.json	physiological response to wounding	http://purl.obolibrary.org/obo/GO_0009611		
GO:0009612	biolink:BiologicalProcess	response to mechanical stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.		hp.json	chemi-mechanical coupling|mechanical stimulus response	http://purl.obolibrary.org/obo/GO_0009612		
UBERON:0002203	biolink:AnatomicalEntity	vasculature of eye	Vasculature that is part of the eye region.	TAO:0007057|FMA:74743|ZFA:0007057|SCTID:123846009	hp.json	eye vascular network|eye vasculature|ocular vasculature|ocular blood vessel|optic vasculature|vascular network of eye	http://purl.obolibrary.org/obo/UBERON_0002203		vertebrate_core|pheno_slim|human_reference_atlas
UBERON:0002202	biolink:AnatomicalEntity	submucosa of trachea	A submucosa that is part of a trachea.	NCIT:C49307|MA:0001860|FMA:7472|EMAPA:35879|BTO:0002115|UMLS:C0225586	hp.json	submucosa of windpipe|submucous layer of trachea|tracheal submucosa|windpipe submucosa|trachea submucosa	http://purl.obolibrary.org/obo/UBERON_0002202		pheno_slim
UBERON:0004867	biolink:AnatomicalEntity	orbital cavity	Anatomical cavity bounded by the orbital region of the cranium and forming the location of some or all of the eye.	ZFA:0005558|FMA:84961|AAO:0000343	hp.json	orbit	http://purl.obolibrary.org/obo/UBERON_0004867		
UBERON:0004864	biolink:AnatomicalEntity	vasculature of retina	A vasculature that is part of a retina [Automatically generated definition].	MESH:D012171|XAO:0004153|FMA:76552	hp.json	set of blood vessels of retina|retina vasculature|set of retinal blood vessels|retina vasculature of camera-type eye|retinal blood vessels set|vasa sanguinea retinae|retinal blood vessels|retinal vasculature	http://purl.obolibrary.org/obo/UBERON_0004864		pheno_slim|human_reference_atlas
GO:0009615	biolink:BiologicalProcess	response to virus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.		hp.json	response to viruses	http://purl.obolibrary.org/obo/GO_0009615		
UBERON:0002204	biolink:AnatomicalEntity	musculoskeletal system	Anatomical system that consists of the muscular and skeletal systems.	MA:0002418|CALOHA:TS-1311|XAO:0000168|VHOG:0001275|VSAO:0000031|UMLS:C0026860|AAO:0010546|EV:0100139|MESH:D009141|NCIT:C12754|EMAPA:32714|Wikipedia:Musculoskeletal_system|FMA:7482|OpenCyc:Mx4rQRpVNgAKEdyHxgDggVfs8g|GAID:98|SCTID:278858007	hp.json	musculo-skeletal system	http://purl.obolibrary.org/obo/UBERON_0002204		uberon_slim
UBERON:0004862	biolink:AnatomicalEntity	left lung alveolus	An alveolus that is part of a left lung [Automatically generated definition].	MA:0001777|NCIT:C49251|UMLS:C1708673|EMAPA:19182	hp.json	alveolus of lobe of left lung|alveolus of left lung	http://purl.obolibrary.org/obo/UBERON_0004862		
GO:0009617	biolink:BiologicalProcess	response to bacterium	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.		hp.json	response to bacteria	http://purl.obolibrary.org/obo/GO_0009617		
HP:0041145	biolink:PhenotypicFeature	Fractured acetabular part of hip bone	A partial or complete breakage of the acetabular part of hip bone.		hp.json	bone acetabular part of hip bone	http://purl.obolibrary.org/obo/HP_0041145		
UBERON:0004863	biolink:AnatomicalEntity	thoracic sympathetic nerve trunk	A sympathetic nerve trunk that is part of a thorax [Automatically generated definition].	EMAPA:37657|MA:0001165|FMA:6262|NCIT:C52827|UMLS:C1710393	hp.json	thorax sympathetic nerve trunk|nerve trunk of sympathetic part of autonomic division of nervous system of thorax|thoracic sympathetic trunk|thorax nerve trunk of sympathetic nervous system|sympathetic nervous system nerve trunk of thorax|sympathetic nerve trunk of thorax|thoracic part of sympathetic trunk|thorax sympathetic nervous system nerve trunk|thorax nerve trunk of sympathetic part of autonomic division of nervous system|nerve trunk of sympathetic nervous system of thorax|thoracic sympathetic chain	http://purl.obolibrary.org/obo/UBERON_0004863		
HP:0041146	biolink:PhenotypicFeature	Fractured coccyx	A partial or complete breakage of the coccyx.		hp.json	bone coccyx	http://purl.obolibrary.org/obo/HP_0041146		
HP:0041143	biolink:PhenotypicFeature	Fractured tibia	A partial or complete breakage of the tibia.		hp.json	Tibial fracture|Fracture of the tibia|Broken tibia|bone tibia	http://purl.obolibrary.org/obo/HP_0041143		
UBERON:0002201	biolink:AnatomicalEntity	vasculature of trunk	A vasculature that is part of a trunk [Automatically generated definition].	FMA:74712|ZFA:0005024|TAO:0005024	hp.json	torso vascular network|trunk vascular network|vascular network of trunk|vascular network of torso|vasculature of torso|trunk vasculature|torso vasculature	http://purl.obolibrary.org/obo/UBERON_0002201		vertebrate_core
CHEBI:33273	biolink:ChemicalSubstance	polyatomic anion	An anion consisting of more than one atom.		hp.json	polyatomic anions	http://purl.obolibrary.org/obo/CHEBI_33273		3_STAR
UBERON:0002200	biolink:AnatomicalEntity	vasculature of head	Vasculature that is part of a head [Automatically generated definition].	ZFA:0001267|TAO:0001267|FMA:74710|EFO:0003656|XAO:0004152	hp.json	vasculature of adult head|head vascular network|vascular network of adult head|head vasculature|adult head vascular network|vascular network of head|cranial vasculature|adult head vasculature	http://purl.obolibrary.org/obo/UBERON_0002200		vertebrate_core|efo_slim
HP:0041144	biolink:PhenotypicFeature	Fractured clavicle bone	A partial or complete breakage of the clavicle bone.		hp.json	bone clavicle bone	http://purl.obolibrary.org/obo/HP_0041144		
UBERON:0004861	biolink:AnatomicalEntity	right lung alveolus	An alveolus that is part of a right lung [Automatically generated definition].	MA:0001786|UMLS:C1709959|EMAPA:35997|NCIT:C49278	hp.json	alveolus of right lung	http://purl.obolibrary.org/obo/UBERON_0004861		
HP:0100059	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the 3rd toe		UMLS:C4022362	hp.json	Fragmentation of the end part of the 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100059		
HP:0041158	biolink:PhenotypicFeature	obsolete Fractured trunk			hp.json		http://purl.obolibrary.org/obo/HP_0041158		
HP:0041159	biolink:PhenotypicFeature	Fractured rib	A partial or complete breakage of the rib.		hp.json	bone rib	http://purl.obolibrary.org/obo/HP_0041159		
UBERON:0004848	biolink:AnatomicalEntity	respiratory system arterial endothelium	An endothelium of artery that is part of a respiratory system [Automatically generated definition].	MA:0001801|EMAPA:37566	hp.json	artery endothelium of apparatus respiratorius|respiratory system artery endothelium|arterial endothelium of respiratory system|endothelium of artery of respiratory system|apparatus respiratorius artery endothelium|apparatus respiratorius endothelium of artery|endothelium of artery of apparatus respiratorius|arterial endothelium of apparatus respiratorius|apparatus respiratorius arterial endothelium|artery endothelium of respiratory system|respiratory system endothelium of artery	http://purl.obolibrary.org/obo/UBERON_0004848		human_reference_atlas
HP:0100057	biolink:PhenotypicFeature	Cone-shaped epiphyses of the 3rd toe		UMLS:C4022364	hp.json	Cone-shaped end part of the 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100057		
HP:0100058	biolink:PhenotypicFeature	Enlarged epiphyses of the 3rd toe		UMLS:C4022363	hp.json	Enlarged end part of the 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100058		
UBERON:0004849	biolink:AnatomicalEntity	respiratory system venous endothelium	An endothelium of vein that is part of a respiratory system [Automatically generated definition].	EMAPA:37585|MA:0001811	hp.json	apparatus respiratorius venous endothelium|respiratory system endothelium of vein|vein endothelium of respiratory system|endothelium of vein of apparatus respiratorius|venous endothelium of apparatus respiratorius|respiratory system vein endothelium|venous endothelium of respiratory system|endothelium of vein of respiratory system|vein endothelium of apparatus respiratorius|apparatus respiratorius vein endothelium|apparatus respiratorius endothelium of vein	http://purl.obolibrary.org/obo/UBERON_0004849		human_reference_atlas
HP:0100055	biolink:PhenotypicFeature	Absent epiphyses of the 3rd toe		UMLS:C4022366	hp.json	Absent end part of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100055		
HP:0100056	biolink:PhenotypicFeature	Bracket epiphyses of the 3rd toe		UMLS:C4022365	hp.json	Bracket shaped end part of 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100056		
HP:0100053	biolink:PhenotypicFeature	Stippling of the epiphyses of the 2nd toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 2nd toe.	UMLS:C4022368	hp.json	Speckled calcifications in the end part of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100053		
GO:0010613	biolink:BiologicalProcess	positive regulation of cardiac muscle hypertrophy	Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0010613		
HP:0100054	biolink:PhenotypicFeature	Triangular epiphyses of the 2nd toe		UMLS:C4022367	hp.json	Triangular end part of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100054		
GO:0010614	biolink:BiologicalProcess	negative regulation of cardiac muscle hypertrophy	Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0010614		
GO:0010611	biolink:BiologicalProcess	regulation of cardiac muscle hypertrophy	Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0010611		
HP:0100051	biolink:PhenotypicFeature	Pseudoepiphyses of the 2nd toe		UMLS:C4022370	hp.json		http://purl.obolibrary.org/obo/HP_0100051		
HP:0100052	biolink:PhenotypicFeature	Small epiphyses of the 2nd toe		UMLS:C4022369	hp.json	Small end part of the 2nd toe bone	http://purl.obolibrary.org/obo/HP_0100052		
GO:0010612	biolink:BiologicalProcess	regulation of cardiac muscle adaptation	Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.		hp.json		http://purl.obolibrary.org/obo/GO_0010612		
HP:0100050	biolink:PhenotypicFeature	Ivory epiphyses of the 2nd toe	Epiphyses of the 2nd toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.	UMLS:C4022371	hp.json	Increased bone density of end part of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100050		
GO:0046651	biolink:BiologicalProcess	lymphocyte proliferation	The expansion of a lymphocyte population by cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0046651		
GO:0010615	biolink:BiologicalProcess	positive regulation of cardiac muscle adaptation	Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.		hp.json		http://purl.obolibrary.org/obo/GO_0010615		
GO:0010616	biolink:BiologicalProcess	negative regulation of cardiac muscle adaptation	Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.		hp.json		http://purl.obolibrary.org/obo/GO_0010616		
CHEBI:33286	biolink:ChemicalSubstance	agrochemical	An agrochemical is a substance that is used in agriculture or horticulture.	Wikipedia:Agrochemical	hp.json	agrichemicals|agricultural chemicals|agrichemical|agrochemicals	http://purl.obolibrary.org/obo/CHEBI_33286		3_STAR
CHEBI:33287	biolink:ChemicalSubstance	fertilizer	A fertilizer is any substance that is added to soil or water to assist the growth of plants.		hp.json	fertilizers|fertiliser	http://purl.obolibrary.org/obo/CHEBI_33287		3_STAR
GO:0009620	biolink:BiologicalProcess	response to fungus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.		hp.json	response to fungi	http://purl.obolibrary.org/obo/GO_0009620		
HP:0041152	biolink:PhenotypicFeature	Fractured sternoclavicular joint	A partial or complete breakage of the sternoclavicular joint.		hp.json	bone sternoclavicular joint	http://purl.obolibrary.org/obo/HP_0041152		
HP:0041153	biolink:PhenotypicFeature	Fractured ankle	A fracture or multiple fractures of one or more of three bones in the ankle joint: the tibia (shinbone), the fibula (outer ankle bone), and the talus (which is the bone that connects your leg to your foot).		hp.json	bone ankle joint	http://purl.obolibrary.org/obo/HP_0041153		
CHEBI:33280	biolink:ChemicalSubstance	molecular messenger			hp.json	chemical messenger	http://purl.obolibrary.org/obo/CHEBI_33280		3_STAR
HP:0041150	biolink:PhenotypicFeature	Fractured cuboid bone	A partial or complete breakage of the cuboid bone.		hp.json	bone cuboid bone	http://purl.obolibrary.org/obo/HP_0041150		
CHEBI:33281	biolink:ChemicalSubstance	antimicrobial agent	A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.	PMID:22958833|PMID:22849268|PMID:22849276|PMID:12964249|PMID:22117953|PMID:22439833	hp.json	microbicide|microbicides|Antibiotika|antimicrobials|antibiotics|antimicrobial agents|antibiotic|Antibiotikum|antibiotique|antimicrobial	http://purl.obolibrary.org/obo/CHEBI_33281		3_STAR
UBERON:0004854	biolink:AnatomicalEntity	gastrointestinal system mesentery	A mesentery that is part of a digestive system [Automatically generated definition].	MA:0001900|EMAPA:37068	hp.json	mesentery of digestive system|mesentery of gastrointestinal system|digestive system mesentery	http://purl.obolibrary.org/obo/UBERON_0004854		pheno_slim
GO:0009628	biolink:BiologicalProcess	response to abiotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.		hp.json	response to abiotic stress	http://purl.obolibrary.org/obo/GO_0009628		gocheck_do_not_manually_annotate|goslim_plant|goslim_metagenomics
UBERON:0004851	biolink:AnatomicalEntity	aorta endothelium	The thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall.	MA:0000701|BTO:0000394|CALOHA:TS-0047|EMAPA:35134|NCIT:C49190|UMLS:C1706824|EFO:0002597	hp.json	trunk of systemic arterial tree endothelium|endothelium of trunk of aortic tree|endothelium of adult aorta|adult aorta endothelium|trunk of aortic tree endothelium|aortic endothelium|endothelium of aorta|endothelium of trunk of systemic arterial tree	http://purl.obolibrary.org/obo/UBERON_0004851		pheno_slim|efo_slim
CHEBI:33282	biolink:ChemicalSubstance	antibacterial agent	A substance (or active part thereof) that kills or slows the growth of bacteria.		hp.json	bactericide|bactericides|antibacterials|antibacterial agents	http://purl.obolibrary.org/obo/CHEBI_33282		3_STAR
HP:0041156	biolink:PhenotypicFeature	Fractured orbit of skull	A partial or complete breakage of the orbit of skull.		hp.json	bone orbit of skull	http://purl.obolibrary.org/obo/HP_0041156		
UBERON:0004852	biolink:AnatomicalEntity	cardiovascular system endothelium	An endothelium that is part of the cardiovascular system.	EMAPA:35201|TAO:0002171|XAO:0000356|GAID:519|BTO:0001853|UMLS:C0014261|MA:0000717|VHOG:0001217|MESH:D004730|ZFA:0001639|NCIT:C13053	hp.json	vascular endothelia|endothelia	http://purl.obolibrary.org/obo/UBERON_0004852		vertebrate_core
HP:0041157	biolink:PhenotypicFeature	Fractured larynx	A partial or complete breakage of the larynx.		hp.json	bone larynx	http://purl.obolibrary.org/obo/HP_0041157		
HP:0041154	biolink:PhenotypicFeature	Fractured elbow joint	A partial or complete breakage of the elbow joint.		hp.json	bone elbow joint	http://purl.obolibrary.org/obo/HP_0041154		
CHEBI:33284	biolink:ChemicalSubstance	nutrient	A nutrient is a food component that an organism uses to survive and grow.		hp.json	nutrients	http://purl.obolibrary.org/obo/CHEBI_33284		3_STAR
CHEBI:33285	biolink:ChemicalSubstance	heteroorganic entity	A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms.		hp.json	heteroorganic entities|organoelement compounds	http://purl.obolibrary.org/obo/CHEBI_33285		3_STAR
UBERON:0004850	biolink:AnatomicalEntity	lymph node endothelium	An endothelium that is part of a lymph node [Automatically generated definition].	MA:0000741|EMAPA:35526	hp.json	endothelium of lymph node	http://purl.obolibrary.org/obo/UBERON_0004850		
HP:0041155	biolink:PhenotypicFeature	Fractured mandible	A partial or complete breakage of the mandible.		hp.json	bone mandible	http://purl.obolibrary.org/obo/HP_0041155		
GO:0046660	biolink:BiologicalProcess	female sex differentiation	The establishment of the sex of a female organism by physical differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0046660		
HP:0100068	biolink:PhenotypicFeature	Cone-shaped epiphyses of the 4th toe		UMLS:C4022353	hp.json	Cone-shaped end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0100068		
HP:0100069	biolink:PhenotypicFeature	Enlarged epiphyses of the 4th toe		UMLS:C4022352	hp.json	Enlarged end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0100069		
UBERON:0004835	biolink:AnatomicalEntity	epididymis smooth muscle	A portion of smooth muscle tissue that is part of a epididymis [Automatically generated definition].	MA:0001736|EMAPA:30747	hp.json	epididymis involuntary muscle|epididymis non-striated muscle|epididymis smooth muscle tissue|non-striated muscle of epididymis|involuntary muscle of epididymis|smooth muscle of epididymis|smooth muscle tissue of epididymis	http://purl.obolibrary.org/obo/UBERON_0004835		
HP:0100066	biolink:PhenotypicFeature	Absent epiphyses of the 4th toe		UMLS:C4022355	hp.json	Absent end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0100066		
HP:0100067	biolink:PhenotypicFeature	Bracket epiphyses of the 4th toe		UMLS:C4022354	hp.json	Bracket shaped end part of 4th toe bone	http://purl.obolibrary.org/obo/HP_0100067		
HP:0100064	biolink:PhenotypicFeature	Stippling of the epiphyses of the 3rd toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 3rd toe.	UMLS:C4022357	hp.json	Speckled calcifications in the end part of the 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100064		
GO:0046668	biolink:BiologicalProcess	regulation of retinal cell programmed cell death	Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the retina.		hp.json	regulation of retinal programmed cell death	http://purl.obolibrary.org/obo/GO_0046668		
GO:0046667	biolink:BiologicalProcess	compound eye retinal cell programmed cell death	Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium.		hp.json		http://purl.obolibrary.org/obo/GO_0046667		
HP:0100065	biolink:PhenotypicFeature	Triangular epiphyses of the 3rd toe		UMLS:C4022356	hp.json	Triangular end part of the 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100065		
HP:0100062	biolink:PhenotypicFeature	Pseudoepiphyses of the 3rd toe		UMLS:C4022359	hp.json		http://purl.obolibrary.org/obo/HP_0100062		
GO:0046666	biolink:BiologicalProcess	retinal cell programmed cell death	Programmed cell death that occurs in the developing retina.		hp.json	programmed cell death, retinal cells|retinal programmed cell death|programmed cell death, retina cells|retina programmed cell death|retina cell programmed cell death	http://purl.obolibrary.org/obo/GO_0046666		
HP:0100063	biolink:PhenotypicFeature	Small epiphyses of the 3rd toe		UMLS:C4022358	hp.json	Small end part of the 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100063		
HP:0100060	biolink:PhenotypicFeature	Irregular epiphyses of the 3rd toe		UMLS:C4022361	hp.json	Irregular end part of the 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100060		
HP:0100061	biolink:PhenotypicFeature	Ivory epiphyses of the 3rd toe	Epiphyses of the 3rd toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.	UMLS:C4022360	hp.json	Increased bone density of end part of the 3rd toe bone	http://purl.obolibrary.org/obo/HP_0100061		
GO:0046661	biolink:BiologicalProcess	male sex differentiation	The establishment of the sex of a male organism by physical differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0046661		
CHEBI:33253	biolink:ChemicalSubstance	nucleon	Heavy nuclear particle: proton or neutron.		hp.json	nucleon|nucleon|Nukleonen|nucleons|Nukleon	http://purl.obolibrary.org/obo/CHEBI_33253		3_STAR
CHEBI:33256	biolink:ChemicalSubstance	primary amide	A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group.		hp.json	primary amide|primary amides	http://purl.obolibrary.org/obo/CHEBI_33256		3_STAR
CHEBI:33259	biolink:ChemicalSubstance	elemental molecular entity	A molecular entity all atoms of which have the same atomic number.		hp.json	homoatomic molecular entities|homoatomic molecular entity|homoatomic entity	http://purl.obolibrary.org/obo/CHEBI_33259		3_STAR
GO:0071626	biolink:BiologicalProcess	mastication	The process of biting and mashing food with the teeth prior to swallowing.		hp.json	chewing	http://purl.obolibrary.org/obo/GO_0071626		
GO:0046669	biolink:BiologicalProcess	regulation of compound eye retinal cell programmed cell death	Any process that modulates the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.		hp.json	regulation of retinal cell programmed cell death	http://purl.obolibrary.org/obo/GO_0046669		
GO:0071625	biolink:NamedThing	vocalization behavior			hp.json		http://purl.obolibrary.org/obo/GO_0071625		
GO:0071624	biolink:BiologicalProcess	positive regulation of granulocyte chemotaxis	Any process that increases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071624		
HP:0041163	biolink:PhenotypicFeature	Fractured manual digit	A partial or complete breakage of the manual digit.		hp.json	bone manual digit	http://purl.obolibrary.org/obo/HP_0041163		
HP:0041164	biolink:PhenotypicFeature	Fractured talus	A partial or complete breakage of the talus.		hp.json	bone talus	http://purl.obolibrary.org/obo/HP_0041164		
GO:0071623	biolink:BiologicalProcess	negative regulation of granulocyte chemotaxis	Any process that decreases the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071623		
GO:0071622	biolink:BiologicalProcess	regulation of granulocyte chemotaxis	Any process that modulates the rate, frequency or extent of granulocyte chemotaxis. Granulocyte chemotaxis is the movement of a granulocyte in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071622		
HP:0041161	biolink:PhenotypicFeature	obsolete Fractured pelvic region of trunk			hp.json		http://purl.obolibrary.org/obo/HP_0041161		
CHEBI:59888	biolink:ChemicalSubstance	gamma-aminobutyric acid zwitterion	Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group.	Gmelin:1041559	hp.json	4-ammoniobutanoate|4-azaniumylbutanoate|4-aminobutanoate	http://purl.obolibrary.org/obo/CHEBI_59888		3_STAR
HP:0041162	biolink:PhenotypicFeature	Fractured foot bone	A partial or complete breakage of the foot bone, such as the metatarsal or toe.		hp.json	Fractured pes|Metatarsal fracture|Broken foot|bone pes	http://purl.obolibrary.org/obo/HP_0041162		
GO:0071621	biolink:BiologicalProcess	granulocyte chemotaxis	The movement of a granulocyte in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071621		
HP:0041167	biolink:PhenotypicFeature	Fractured cervical vertebra	A partial or complete breakage of the cervical vertebra.		hp.json	bone cervical vertebra	http://purl.obolibrary.org/obo/HP_0041167		
CHEBI:33250	biolink:ChemicalSubstance	atom	A chemical entity constituting the smallest component of an element having the chemical properties of the element.		hp.json	elements|atome|atom|atoms|atomo|atomus|element	http://purl.obolibrary.org/obo/CHEBI_33250		3_STAR
HP:0041168	biolink:PhenotypicFeature	Fractured lumbar vertebra	A partial or complete breakage of the lumbar vertebra.		hp.json	bone lumbar vertebra	http://purl.obolibrary.org/obo/HP_0041168		
HP:0041165	biolink:PhenotypicFeature	Fractured maxilla	A partial or complete breakage of the maxilla.		hp.json	bone maxilla	http://purl.obolibrary.org/obo/HP_0041165		
CHEBI:33252	biolink:ChemicalSubstance	atomic nucleus	A nucleus is the positively charged central portion of an atom, excluding the orbital electrons.		hp.json	Atomkern|Kern|nucleus|nuclei|nucleo atomico|noyau|noyau atomique|nucleo|nucleus atomi	http://purl.obolibrary.org/obo/CHEBI_33252		3_STAR
HP:0041166	biolink:PhenotypicFeature	Fractured vertebra	A partial or complete breakage of the vertebra.		hp.json	bone vertebra	http://purl.obolibrary.org/obo/HP_0041166		
GO:0046671	biolink:BiologicalProcess	negative regulation of retinal cell programmed cell death	Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the retina.		hp.json	down regulation of retinal programmed cell death|downregulation of retinal programmed cell death|inhibition of retinal programmed cell death|negative regulation of retinal programmed cell death|down-regulation of retinal programmed cell death	http://purl.obolibrary.org/obo/GO_0046671		
GO:0046670	biolink:BiologicalProcess	positive regulation of retinal cell programmed cell death	Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the retina.		hp.json	positive regulation of retinal programmed cell death|up-regulation of retinal programmed cell death|up regulation of retinal programmed cell death|activation of retinal programmed cell death|stimulation of retinal programmed cell death|upregulation of retinal programmed cell death	http://purl.obolibrary.org/obo/GO_0046670		
UBERON:0004829	biolink:AnatomicalEntity	urethra skeletal muscle tissue	A portion of skeletal muscle tissue that is part of a urethra [Automatically generated definition].	EMAPA:37788|MA:0001690	hp.json	skeletal muscle of urethra|urethra skeletal muscle|skeletal muscle tissue of urethra|urethra skeletal muscle tissue|urethral skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0004829		
HP:0100079	biolink:PhenotypicFeature	Cone-shaped epiphyses of the 5th toe		UMLS:C4022342	hp.json	Cone-shaped end part of the pinky toe bone|Cone-shaped end part of the pinkie toe bone|Cone-shaped end part of the little toe bone	http://purl.obolibrary.org/obo/HP_0100079		
UBERON:0004827	biolink:AnatomicalEntity	thyroid gland medulla	A medulla that is part of a thyroid [Automatically generated definition].	MA:0000132|EMAPA:37768	hp.json	thyroid follicle medulla|thyroid gland follicle medulla|thyroid medulla|medulla of thyroid follicle|medulla of thyroid gland follicle|medulla of thyroid gland|medulla of thyroid	http://purl.obolibrary.org/obo/UBERON_0004827		
HP:0100077	biolink:PhenotypicFeature	Absent epiphyses of the 5th toe		UMLS:C4022344	hp.json	Absent end part of the pinkie toe bone|Absent end part of the pinky toe bone|Absent end part of the little toe bone	http://purl.obolibrary.org/obo/HP_0100077		
HP:0100078	biolink:PhenotypicFeature	Bracket epiphyses of the 5th toe		UMLS:C4022343	hp.json	Bracket shaped end part of pinkie toe bone|Bracket shaped end part of little toe bone|Bracket shaped end part of pinky toe bone	http://purl.obolibrary.org/obo/HP_0100078		
HP:0100075	biolink:PhenotypicFeature	Stippling of the epiphyses of the 4th toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 4th toe.	UMLS:C4022346	hp.json	Speckled calcifications in the end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0100075		
HP:0100076	biolink:PhenotypicFeature	Triangular epiphyses of the 4th toe		UMLS:C4022345	hp.json	Triangular end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0100076		
HP:0100073	biolink:PhenotypicFeature	Pseudoepiphyses of the 4th toe		UMLS:C4022348	hp.json		http://purl.obolibrary.org/obo/HP_0100073		
HP:0100074	biolink:PhenotypicFeature	Small epiphyses of the 4th toe		UMLS:C4022347	hp.json	Small end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0100074		
GO:0046676	biolink:NamedThing	negative regulation of insulin secretion			hp.json		http://purl.obolibrary.org/obo/GO_0046676		
HP:0100071	biolink:PhenotypicFeature	Irregular epiphyses of the 4th toe		UMLS:C4022350	hp.json	Irregular end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0100071		
HP:0100072	biolink:PhenotypicFeature	Ivory epiphyses of the 4th toe	Epiphyses of the 4th toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.	UMLS:C4022349	hp.json	Increased bone density of end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0100072		
CHEBI:47891	biolink:ChemicalSubstance	steroid acid	Any steroid substituted by at least one carboxy group.		hp.json	steroid acids	http://purl.obolibrary.org/obo/CHEBI_47891		3_STAR
GO:0046673	biolink:BiologicalProcess	negative regulation of compound eye retinal cell programmed cell death	Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.		hp.json	inhibition of retinal cell programmed cell death|negative regulation of retina cell programmed cell death|downregulation of retinal cell programmed cell death|down regulation of retinal cell programmed cell death|negative regulation of retinal cell programmed cell death|down-regulation of retinal cell programmed cell death	http://purl.obolibrary.org/obo/GO_0046673		
GO:0046672	biolink:BiologicalProcess	positive regulation of compound eye retinal cell programmed cell death	Any process that activates or increases the frequency, rate or extent of programmed cell death that occurs in the compound eye retina.		hp.json	positive regulation of retinal cell programmed cell death|up regulation of retinal cell programmed cell death|up-regulation of retinal cell programmed cell death|stimulation of retinal cell programmed cell death|activation of retinal cell programmed cell death|upregulation of retinal cell programmed cell death	http://purl.obolibrary.org/obo/GO_0046672		
HP:0100070	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the 4th toe		UMLS:C4022351	hp.json	Fragmentation of the end part of the 4th toe bone	http://purl.obolibrary.org/obo/HP_0100070		
CHEBI:59871	biolink:ChemicalSubstance	D-alpha-amino acid zwitterion	Zwitterionic form of a D-alpha-amino acid having an anionic carboxy group and a protonated amino group.		hp.json	a D-alpha-amino acid|D-alpha-amino acid zwitterions	http://purl.obolibrary.org/obo/CHEBI_59871		3_STAR
UBERON:0004833	biolink:AnatomicalEntity	lip skeletal muscle	A portion of skeletal muscle tissue that is part of a lip [Automatically generated definition].	EMAPA:37642|MA:0001578	hp.json	skeletal muscle of lip|skeletal muscle tissue of lip|lip skeletal muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004833		
HP:0041174	biolink:PhenotypicFeature	Fractured distal phalanx of manus	A partial or complete breakage of the distal phalanx of manus.		hp.json	bone distal phalanx of manus	http://purl.obolibrary.org/obo/HP_0041174		
UBERON:0004834	biolink:AnatomicalEntity	hepatic duct smooth muscle	Smooth muscle tissue in all or part of a hepatic duct.	EMAPA:37598|MA:0001640	hp.json		http://purl.obolibrary.org/obo/UBERON_0004834		
HP:0041175	biolink:PhenotypicFeature	Fractured middle phalanx of pes	A partial or complete breakage of the middle phalanx of pes.		hp.json	bone middle phalanx of pes	http://purl.obolibrary.org/obo/HP_0041175		
HP:0041172	biolink:PhenotypicFeature	Fractured fused sacrum	A partial or complete breakage of the fused sacrum.		hp.json	bone fused sacrum	http://purl.obolibrary.org/obo/HP_0041172		
UBERON:0004831	biolink:AnatomicalEntity	esophagus skeletal muscle	A portion of skeletal muscle tissue that is part of a esophagus [Automatically generated definition].	EMAPA:36523|MA:0001572	hp.json	esophagus skeletal muscle tissue|skeletal muscle of esophagus	http://purl.obolibrary.org/obo/UBERON_0004831		
UBERON:0004832	biolink:AnatomicalEntity	anal region skeletal muscle	A portion of skeletal muscle tissue that is part of an anal region [Automatically generated definition].	EMAPA:37393|MA:0001530	hp.json	skeletal muscle tissue of anal region|anal region skeletal muscle tissue|skeletal muscle of anal triangle|skeletal muscle of anal part of perineum|anal part of perineum skeletal muscle tissue|anal triangle skeletal muscle tissue|skeletal muscle of anal region|skeletal muscle tissue of anal triangle|skeletal muscle tissue of anal part of perineum|anal triangle skeletal muscle|anal part of perineum skeletal muscle	http://purl.obolibrary.org/obo/UBERON_0004832		
GO:0009605	biolink:BiologicalProcess	response to external stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.		hp.json	response to environmental stimulus	http://purl.obolibrary.org/obo/GO_0009605		gocheck_do_not_manually_annotate|goslim_plant|goslim_drosophila
HP:0041173	biolink:PhenotypicFeature	Fractured metacarpophalangeal joint	A partial or complete breakage of the metacarpophalangeal joint.		hp.json	bone metacarpophalangeal joint	http://purl.obolibrary.org/obo/HP_0041173		
CHEBI:59876	biolink:ChemicalSubstance	N-acyl-D-alpha-amino acid anion	The conjugate base of an N-acyl-D-alpha-amino acid arising from deprotonation of the C-1 carboxy group.		hp.json	N-acyl-D-alpha-amino acid(1-)|an N-acyl-D-amino acid	http://purl.obolibrary.org/obo/CHEBI_59876		3_STAR
HP:0041178	biolink:PhenotypicFeature	Fractured distal phalanx of manual digit 4	A partial or complete breakage of the distal phalanx of manual digit 4.		hp.json	bone distal phalanx of manual digit 4	http://purl.obolibrary.org/obo/HP_0041178		
UBERON:0004830	biolink:AnatomicalEntity	respiratory system skeletal muscle	A portion of skeletal muscle tissue that is part of a respiratory system [Automatically generated definition].	EMAPA:37583|MA:0001829	hp.json	skeletal muscle of respiratory system|skeletal muscle tissue of apparatus respiratorius|skeletal muscle tissue of respiratory system|skeletal muscle of apparatus respiratorius|respiratory system skeletal muscle tissue	http://purl.obolibrary.org/obo/UBERON_0004830		
CHEBI:33261	biolink:ChemicalSubstance	organosulfur compound	An organosulfur compound is a compound containing at least one carbon-sulfur bond.	Wikipedia:Organosulfur_compounds	hp.json	organosulfur compounds|organosulfur compound	http://purl.obolibrary.org/obo/CHEBI_33261		3_STAR
GO:0009607	biolink:BiologicalProcess	response to biotic stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.		hp.json	response to biotic stress	http://purl.obolibrary.org/obo/GO_0009607		gocheck_do_not_manually_annotate|goslim_plant|goslim_metagenomics
HP:0041179	biolink:PhenotypicFeature	Fractured distal phalanx of manual digit 5	A partial or complete breakage of the distal phalanx of manual digit 5.		hp.json	bone distal phalanx of manual digit 5	http://purl.obolibrary.org/obo/HP_0041179		
CHEBI:59874	biolink:ChemicalSubstance	N-acyl-L-alpha-amino acid anion	A carboxylic acid anion that is the conjugate base of an N-acyl-L-alpha-amino acid arising from deprotonation of the C-1 carboxy group.		hp.json	an N-acyl-L-amino acid|N-acyl-L-alpha-amino acid(1-)	http://purl.obolibrary.org/obo/CHEBI_59874		3_STAR
HP:0041176	biolink:PhenotypicFeature	Fractured distal phalanx of manual digit 2	A partial or complete breakage of the distal phalanx of manual digit 2.		hp.json	bone distal phalanx of manual digit 2	http://purl.obolibrary.org/obo/HP_0041176		
CHEBI:33262	biolink:ChemicalSubstance	elemental oxygen			hp.json		http://purl.obolibrary.org/obo/CHEBI_33262		3_STAR
CHEBI:33263	biolink:ChemicalSubstance	diatomic oxygen			hp.json		http://purl.obolibrary.org/obo/CHEBI_33263		3_STAR
HP:0041177	biolink:PhenotypicFeature	Fractured distal phalanx of manual digit 3	A partial or complete breakage of the distal phalanx of manual digit 3.		hp.json	bone distal phalanx of manual digit 3	http://purl.obolibrary.org/obo/HP_0041177		
HP:0031782	biolink:PhenotypicFeature	Microtropia without identity	A type of microtropia in which the manifest movement is demonstrated on the cover-uncover test.		hp.json		http://purl.obolibrary.org/obo/HP_0031782		
HP:0031783	biolink:PhenotypicFeature	Absent coronary sinus	A developmental defect in which the coronary sinus fails to form.	Fyler:2841	hp.json		http://purl.obolibrary.org/obo/HP_0031783		
HP:0031784	biolink:PhenotypicFeature	Abnormal ascending aorta morphology	Any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise.	Fyler:1431	hp.json		http://purl.obolibrary.org/obo/HP_0031784		
HP:0031785	biolink:PhenotypicFeature	Abnormal eyelid movement	An abnormality in voluntary or involuntary eyelid movements or their control.		hp.json		http://purl.obolibrary.org/obo/HP_0031785		
GO:0007077	biolink:BiologicalProcess	mitotic nuclear membrane disassembly	The mitotic cell cycle process in which the controlled partial or complete breakdown of the nuclear membranes during occurs during mitosis.		hp.json	mitotic nuclear envelope catabolism|mitotic nuclear envelope breakdown|mitotic nuclear envelope degradation|mitotic nuclear envelope disassembly|NEB|nuclear envelope breakdown|local NEB	http://purl.obolibrary.org/obo/GO_0007077		
HP:0031780	biolink:PhenotypicFeature	Eosinophilic ascites	A type of ascites in which there are large numbers of eosinophils in the ascitis fluid.		hp.json		http://purl.obolibrary.org/obo/HP_0031780		
GO:0007076	biolink:BiologicalProcess	mitotic chromosome condensation	The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.		hp.json		http://purl.obolibrary.org/obo/GO_0007076		
HP:0031781	biolink:PhenotypicFeature	Microtropia with identity	A type of microtropia with no manifest movement on cover test, the eccentric fixation point coinciding with the angle of ARC.		hp.json		http://purl.obolibrary.org/obo/HP_0031781		
HP:0004157	biolink:PhenotypicFeature	obsolete Accessory middle-finger phalanges			hp.json		http://purl.obolibrary.org/obo/HP_0004157		
UBERON:8400021	biolink:AnatomicalEntity	liver serosa	Hepatic serous coat; peritoneal covering of the liver, enclosing almost all except for a triangular area on its posterior surface (the 'bare area of the liver') and a smaller area where the liver and gallbladder are in direct contact.		hp.json	tunica serosa hepatis|serosa of liver	http://purl.obolibrary.org/obo/UBERON_8400021		
HP:0031786	biolink:PhenotypicFeature	Cogan lid twitch	Transient eyelid retraction during refixation from down to straight ahead.		hp.json	Cogan eyelid twitch|Eyelid twitch|Lid twitch	http://purl.obolibrary.org/obo/HP_0031786		
HP:0031787	biolink:PhenotypicFeature	Oblique astigmatism	Astigmatism in which the refractive power of the vertical meridian is the greatest.		hp.json		http://purl.obolibrary.org/obo/HP_0031787		
UBERON:8400023	biolink:AnatomicalEntity	liver subserosa	Subserosal tissue of liver. A zone of areolar connective tissue lying beneath the serous coat of the liver and distinguished with difficulty from the fibrous capsule of Glisson.		hp.json	subserosal tissue of liver|tela subserosa hepatis|subserous layer of liver|tela subserosa (hepar)|hepatic subserosa	http://purl.obolibrary.org/obo/UBERON_8400023		
HP:0031788	biolink:PhenotypicFeature	With the rule astigmatism	Refractive error in which the vertical meridian is relatively hypermetropic and the horizontal meridian is relatively myopic (or ocular astigmatism in which the refractive power of the horizontal meridian is the greatest).		hp.json		http://purl.obolibrary.org/obo/HP_0031788		
HP:0031789	biolink:PhenotypicFeature	Against the rule astigmatism	Astigmatism with more plus power on the horizontal meridian.		hp.json		http://purl.obolibrary.org/obo/HP_0031789		
HP:0004150	biolink:PhenotypicFeature	Abnormal 3rd finger morphology	An anomaly of the third finger.	UMLS:C4021682	hp.json	Abnormality of the middle finger|Abnormality of the 3rd finger	http://purl.obolibrary.org/obo/HP_0004150		
HP:0004153	biolink:PhenotypicFeature	obsolete Overgrowth of middle finger			hp.json		http://purl.obolibrary.org/obo/HP_0004153		
HP:0041116	biolink:PhenotypicFeature	Fractured left clavicle	A partial or complete breakage of the left clavicle.		hp.json	bone left clavicle	http://purl.obolibrary.org/obo/HP_0041116		
HP:0041117	biolink:PhenotypicFeature	Fractured lower limb segment	A partial or complete breakage of the lower limb segment.		hp.json	bone lower limb segment	http://purl.obolibrary.org/obo/HP_0041117		
HP:0041114	biolink:PhenotypicFeature	Fractured metaphysis of femur	A partial or complete breakage of the metaphysis of femur.		hp.json	bone metaphysis of femur	http://purl.obolibrary.org/obo/HP_0041114		
NBO:0000229	biolink:NamedThing	vestibular behavior phenotype	"Observable characteristic of behavior related to the awareness of body balance and movement." [NBO:GVG]		hp.json	pathological vestibular behaviour	http://purl.obolibrary.org/obo/NBO_0000229		
HP:0041115	biolink:PhenotypicFeature	Fractured right clavicle	A partial or complete breakage of the right clavicle.		hp.json	bone right clavicle	http://purl.obolibrary.org/obo/HP_0041115		
HP:0041118	biolink:PhenotypicFeature	Fractured upper limb segment	A partial or complete breakage of the upper limb segment.		hp.json	bone upper limb segment	http://purl.obolibrary.org/obo/HP_0041118		
HP:0041119	biolink:PhenotypicFeature	Fractured metacarpus skeleton	A partial or complete breakage of the metacarpus skeleton.		hp.json	bone metacarpus skeleton	http://purl.obolibrary.org/obo/HP_0041119		
HP:0031793	biolink:PhenotypicFeature	Increased serum leptin	An increased concentration of leptin in the blood.		hp.json	Elevated circulating leptin level	http://purl.obolibrary.org/obo/HP_0031793		
HP:0031794	biolink:PhenotypicFeature	Decreased circulating glycerol level	A decrease below the normal concentration of glycerol in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031794		
HP:0031795	biolink:PhenotypicFeature	Abnormal circulating glycerol level	Any deviation from the normal concentration of glycerol in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031795		
HP:0031796	biolink:PhenotypicFeature	Recurrent	Applies to a sign, symptom or manifestation that occurs multiple times separated by intervals in which the sign, symptom, or manifestation is not present.		hp.json	Intermittent	http://purl.obolibrary.org/obo/HP_0031796		
GO:0007088	biolink:BiologicalProcess	regulation of mitotic nuclear division	Any process that modulates the frequency, rate or extent of mitosis.		hp.json	regulation of mitosis	http://purl.obolibrary.org/obo/GO_0007088		
HP:0031790	biolink:PhenotypicFeature	Mixed astigmatism	A type of astigmatism in which an unequal curvature of the cornea and some cases additionally of the lens causes one meridian of the eye to be hyperopic (farsighted) and a second meridian that is perpendicular to the first to be myopic (nearsighted).		hp.json		http://purl.obolibrary.org/obo/HP_0031790		
HP:0031791	biolink:PhenotypicFeature	Lenticular astigmatism	A type of astigmatism related to an irregular shape of the lens.		hp.json		http://purl.obolibrary.org/obo/HP_0031791		
HP:0031792	biolink:PhenotypicFeature	Irregular astigmatism	A type of astigmatism in which the principle meridians are not 90 degrees apart and which is associated with loss of vision.		hp.json		http://purl.obolibrary.org/obo/HP_0031792		
HP:0004168	biolink:PhenotypicFeature	obsolete Radially pointed proximal middle-finger phalanx			hp.json		http://purl.obolibrary.org/obo/HP_0004168		
HP:0031797	biolink:PhenotypicFeature	Clinical course	The course a disease typically takes from its onset, progression in time, and eventual resolution or death of the affected individual.		hp.json	Natural history of disease	http://purl.obolibrary.org/obo/HP_0031797		
PATO:0000890	biolink:NamedThing	male sterile	A male fertility quality inhering in a male by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction.		hp.json	male infertile	http://purl.obolibrary.org/obo/PATO_0000890		disposition_slim|value_slim
HP:0031798	biolink:PhenotypicFeature	Elevated circulating apolipoprotein B concentration	Increased circulating level of apolipoprotein B, which is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100.		hp.json	Elevated apolipoprotein B level|Elevated ApoB level	http://purl.obolibrary.org/obo/HP_0031798		
HP:0031799	biolink:PhenotypicFeature	Decreased circulating apolipoprotein AI concentration	Reduced criculating level of apolipoprotein AI, which is the major protein component of high density lipoprotein (HDL) in plasma. Defects in this gene are associated with HDL deficiencies, including Tangier disease.		hp.json	Decreased apo-AI level|Decreased apolipoprotein AI level|Decreased apoA-I level	http://purl.obolibrary.org/obo/HP_0031799		
PATO:0000892	biolink:NamedThing	female sterile	A female fertility quality inhering in a female by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction.		hp.json	female infertile	http://purl.obolibrary.org/obo/PATO_0000892		disposition_slim|value_slim
HP:0004162	biolink:PhenotypicFeature	obsolete Radially pointed middle finger phalanges			hp.json		http://purl.obolibrary.org/obo/HP_0004162		
NBO:0000233	biolink:NamedThing	motivation behavior	"Behavior related to the tendency of an organism to maintain internal equilibrium." [NBO:GVG]		hp.json	behavioral homeostasis|perception of need|maintenance behaviour	http://purl.obolibrary.org/obo/NBO_0000233		
HP:0004161	biolink:PhenotypicFeature	obsolete Periosteal new bone of middle finger phalanges			hp.json		http://purl.obolibrary.org/obo/HP_0004161		
GO:0032024	biolink:NamedThing	positive regulation of insulin secretion			hp.json		http://purl.obolibrary.org/obo/GO_0032024		
GO:0007059	biolink:BiologicalProcess	chromosome segregation	The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.	Wikipedia:Chromosome_segregation	hp.json	chromosome transmission|chromosome division	http://purl.obolibrary.org/obo/GO_0007059		prokaryote_subset|goslim_pir|goslim_drosophila|goslim_chembl|goslim_generic|goslim_yeast
HP:0004138	biolink:PhenotypicFeature	obsolete Metaphyseal abnormality of middle phalanx of the 2nd finger			hp.json		http://purl.obolibrary.org/obo/HP_0004138		
HP:0006799	biolink:PhenotypicFeature	Basal ganglia cysts		UMLS:C1837251	hp.json	Cystic lesions in the basal ganglia	http://purl.obolibrary.org/obo/HP_0006799		
HP:0004139	biolink:PhenotypicFeature	obsolete Flared metaphysis of middle phalanx of index finger			hp.json		http://purl.obolibrary.org/obo/HP_0004139		
HP:0006794	biolink:PhenotypicFeature	Loss of ability to walk in first decade		UMLS:C1846133	hp.json	Loss of ability to walk in first decade	http://purl.obolibrary.org/obo/HP_0006794		
HP:0006790	biolink:PhenotypicFeature	Cerebral cortex with spongiform changes		UMLS:C1857934	hp.json		http://purl.obolibrary.org/obo/HP_0006790		
HP:0004132	biolink:PhenotypicFeature	Dimple on nasal tip	An abnormal indentation of the skin in the region of the nasal tip.	UMLS:C1863349	hp.json	Dimpled tip of nose|Dimple on nasal tip	http://purl.obolibrary.org/obo/HP_0004132		
HP:0041121	biolink:PhenotypicFeature	Fractured epiphysis of fifth metacarpal bone	A partial or complete breakage of the epiphysis of fifth metacarpal bone.		hp.json	bone epiphysis of fifth metacarpal bone	http://purl.obolibrary.org/obo/HP_0041121		
CHEBI:60895	biolink:ChemicalSubstance	D-alpha-amino acid anion	Any alpha-amino acid anion in which the parent amino acid has D-configuration.		hp.json	D-alpha-amino acid anions|D-alpha-amino carboxylate	http://purl.obolibrary.org/obo/CHEBI_60895		3_STAR
HP:0004144	biolink:PhenotypicFeature	obsolete Duplication of terminal index finger phalanx			hp.json		http://purl.obolibrary.org/obo/HP_0004144		
HP:0004143	biolink:PhenotypicFeature	obsolete Radially deviated terminal index finger phalanx			hp.json		http://purl.obolibrary.org/obo/HP_0004143		
NBO:0000259	biolink:NamedThing	psychotic disorder			hp.json		http://purl.obolibrary.org/obo/NBO_0000259		
NBO:0000258	biolink:NamedThing	bipolar disorder	"A mood disorder formerly characterised by alternating periods of mania and depression (and in some cases rapid cycling, mixed states, and psychotic symptoms)." [wikipedia:Bipolar_disorder]		hp.json	bipolar affective disorder|BD|manic depression	http://purl.obolibrary.org/obo/NBO_0000258		
HP:0031740	biolink:PhenotypicFeature	Abnormal horizontal rectus muscle physiology	A functional anomaly of the medial rectus muscle or lateral rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031740		
GO:0007036	biolink:BiologicalProcess	vacuolar calcium ion homeostasis	Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings.		hp.json		http://purl.obolibrary.org/obo/GO_0007036		
HP:0031741	biolink:PhenotypicFeature	Inferior oblique muscle underaction	Reduced ocular movement by the inferior oblique muscle which improves on testing ductions, typically associated with neurogenic palsy.		hp.json		http://purl.obolibrary.org/obo/HP_0031741		
GO:0007034	biolink:BiologicalProcess	vacuolar transport	The directed movement of substances into, out of or within a vacuole.		hp.json		http://purl.obolibrary.org/obo/GO_0007034		goslim_chembl
GO:0007033	biolink:BiologicalProcess	vacuole organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.		hp.json	vacuolar assembly|vacuole biogenesis|vacuole organization and biogenesis|vacuole organisation	http://purl.obolibrary.org/obo/GO_0007033		goslim_pir|goslim_drosophila|goslim_yeast
GO:0007041	biolink:BiologicalProcess	lysosomal transport	The directed movement of substances into, out of or within a lysosome.		hp.json		http://purl.obolibrary.org/obo/GO_0007041		
HP:0031746	biolink:PhenotypicFeature	Superior rectus muscle restriction	Mechanical limitation of the range of movement of the superior rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031746		
HP:0031747	biolink:PhenotypicFeature	Superior rectus muscle underaction	Reduced movement of the superior rectus muscle which improves on testing ductions, typically associated with neurogenic palsy.		hp.json		http://purl.obolibrary.org/obo/HP_0031747		
GO:0007040	biolink:BiologicalProcess	lysosome organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.		hp.json	lysosome organisation|lysosome organization and biogenesis	http://purl.obolibrary.org/obo/GO_0007040		goslim_generic
HP:0031748	biolink:PhenotypicFeature	Abnormal vertical rectus muscle physiology	A functional anomaly of the superior or inferior rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031748		
HP:0031749	biolink:PhenotypicFeature	Abnormal lateral rectus muscle physiology	A functional anomaly of the lateral rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031749		
HP:0031742	biolink:PhenotypicFeature	Inferior rectus muscle underaction	Reduced movement by the inferior rectus muscle which improves on testing ductions, typically associated with neurogenic palsy.		hp.json		http://purl.obolibrary.org/obo/HP_0031742		
HP:0031743	biolink:PhenotypicFeature	Inferior rectus muscle overaction	Excessive action of the inferior rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist.		hp.json		http://purl.obolibrary.org/obo/HP_0031743		
GO:0034654	biolink:BiologicalProcess	nucleobase-containing compound biosynthetic process	The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.		hp.json	nucleobase, nucleoside, nucleotide and nucleic acid formation|nucleobase, nucleoside, nucleotide and nucleic acid synthesis|nucleobase, nucleoside, nucleotide and nucleic acid anabolism|nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis	http://purl.obolibrary.org/obo/GO_0034654		
HP:0031744	biolink:PhenotypicFeature	Superior rectus muscle weakness	Decreased strength of the superior rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031744		
CHEBI:166902	biolink:ChemicalSubstance	noradrenaline(1+)			hp.json	noradrenaline	http://purl.obolibrary.org/obo/CHEBI_166902		2_STAR
HP:0031745	biolink:PhenotypicFeature	Superior rectus muscle overaction	Excessive action of the superior rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist.		hp.json		http://purl.obolibrary.org/obo/HP_0031745		
HP:0004196	biolink:PhenotypicFeature	obsolete Short phalanges of the ring finger			hp.json		http://purl.obolibrary.org/obo/HP_0004196		
NBO:0000266	biolink:NamedThing	cognitive behavior phenotype	"Observable characteristic of behaviour related to cognitive processes." [NBO:RH]		hp.json		http://purl.obolibrary.org/obo/NBO_0000266		
HP:0004195	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the 4th finger	Osteolytic defects of the phalanges of the 4th (ring) finger.	UMLS:C4025409|UMLS:C4020832	hp.json	Lytic defects of the phalanges of the ring finger	http://purl.obolibrary.org/obo/HP_0004195		
NBO:0000265	biolink:NamedThing	personality disorder			hp.json		http://purl.obolibrary.org/obo/NBO_0000265		
HP:0004194	biolink:PhenotypicFeature	obsolete Hypoplastic phalanges of the ring finger			hp.json		http://purl.obolibrary.org/obo/HP_0004194		
HP:0004193	biolink:PhenotypicFeature	obsolete Expanded phalanges of the ring finger			hp.json		http://purl.obolibrary.org/obo/HP_0004193		
HP:0004198	biolink:PhenotypicFeature	obsolete Wide/broad phalanges of the ring finger			hp.json		http://purl.obolibrary.org/obo/HP_0004198		
HP:0004197	biolink:PhenotypicFeature	Symphalangism of the 4th finger	Fusion of two or more bones of the 4th finger.	UMLS:C4021679	hp.json	Fused ring finger bones|Symphalangism of the ring finger	http://purl.obolibrary.org/obo/HP_0004197		
NBO:0000268	biolink:NamedThing	dementia			hp.json		http://purl.obolibrary.org/obo/NBO_0000268		
GO:0007049	biolink:BiologicalProcess	cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.	Wikipedia:Cell_cycle	hp.json	cell-division cycle	http://purl.obolibrary.org/obo/GO_0007049		goslim_candida|goslim_agr|gocheck_do_not_manually_annotate|goslim_pir|goslim_plant|goslim_flybase_ribbon|goslim_chembl|goslim_aspergillus
HP:0031750	biolink:PhenotypicFeature	Lateral rectus muscle weakness	Decreased strength (ability to move) of the lateral rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031750		
HP:0031751	biolink:PhenotypicFeature	Lateral rectus muscle underaction	Reduced movement of the lateral rectus muscle which improves on testing ductions, typically associated with neurogenic palsy.		hp.json		http://purl.obolibrary.org/obo/HP_0031751		
HP:0031752	biolink:PhenotypicFeature	Lateral rectus muscle overaction	Excessive action of the lateral rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist.		hp.json		http://purl.obolibrary.org/obo/HP_0031752		
GO:0007043	biolink:BiologicalProcess	cell-cell junction assembly	The aggregation, arrangement and bonding together of a set of components to form a junction between cells.		hp.json	intercellular junction assembly	http://purl.obolibrary.org/obo/GO_0007043		
HP:0031757	biolink:PhenotypicFeature	Medial rectus muscle restriction	Mechanical limitation of the range of movement of the medial rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031757		
NBO:0000270	biolink:NamedThing	feeding behavior phenotype	"Observable characteristic of behavior associated with the intake of food or liquids." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000270		
GO:0010693	biolink:BiologicalProcess	negative regulation of alkaline phosphatase activity	Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.		hp.json		http://purl.obolibrary.org/obo/GO_0010693		
HP:0031758	biolink:PhenotypicFeature	Lateral rectus muscle restriction	Mechanical limitation of the range of movement of the lateral rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031758		
GO:0010694	biolink:BiologicalProcess	positive regulation of alkaline phosphatase activity	Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.		hp.json		http://purl.obolibrary.org/obo/GO_0010694		
HP:0031759	biolink:PhenotypicFeature	Basic constant esotropia	A form of convergent strabismus (esotropia) in which the deviation is present under all conditions (ie at all distances and at all times).		hp.json	Basic (constant) esotropia	http://purl.obolibrary.org/obo/HP_0031759		
GO:0010692	biolink:BiologicalProcess	regulation of alkaline phosphatase activity	Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.		hp.json		http://purl.obolibrary.org/obo/GO_0010692		
GO:0034641	biolink:BiologicalProcess	cellular nitrogen compound metabolic process	The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.		hp.json	cellular nitrogen compound metabolism	http://purl.obolibrary.org/obo/GO_0034641		goslim_chembl
HP:0031753	biolink:PhenotypicFeature	Medial rectus muscle weakness	Decreased strength of the medial rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031753		
HP:0031754	biolink:PhenotypicFeature	Medial rectus muscle overaction	Excessive action of the medial rectus muscle caused by increased innervation typically as a consequence of palsy or limitation to the ipsilateral antagonist or contralateral synergist.		hp.json		http://purl.obolibrary.org/obo/HP_0031754		
HP:0031755	biolink:PhenotypicFeature	Abnormal rectus muscle physiology	A functional anomaly of a vertical or horizontal rectus muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031755		
GO:0034645	biolink:BiologicalProcess	cellular macromolecule biosynthetic process	The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.		hp.json	cellular macromolecule formation|cellular macromolecule anabolism|cellular biopolymer biosynthetic process|cellular macromolecule biosynthesis|cellular macromolecule synthesis	http://purl.obolibrary.org/obo/GO_0034645		
HP:0031756	biolink:PhenotypicFeature	Medial rectus muscle underaction	Reduced movement of the medial rectus muscle which improves on testing ductions, typically associated with neurogenic palsy.		hp.json		http://purl.obolibrary.org/obo/HP_0031756		
GO:0007019	biolink:BiologicalProcess	microtubule depolymerization	The removal of tubulin heterodimers from one or both ends of a microtubule.		hp.json	microtubule shortening|microtubule depolymerization during nuclear congression|microtubule catastrophe|microtubule disassembly	http://purl.obolibrary.org/obo/GO_0007019		
HP:0004180	biolink:PhenotypicFeature	Short distal phalanx of the 3rd finger	Hypoplasia (congenital reduction in size) of the distal phalanx of the third finger.	UMLS:C4021681	hp.json	Short distal phalanx of the third finger|Short terminal phalanx of middle finger|Hypoplastic/small distal phalanx of the 3rd finger|Short outermost bone of the middle finger	http://purl.obolibrary.org/obo/HP_0004180		
GO:0007018	biolink:BiologicalProcess	microtubule-based movement	A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components.  Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.		hp.json		http://purl.obolibrary.org/obo/GO_0007018		goslim_generic|goslim_drosophila
GO:0007017	biolink:BiologicalProcess	microtubule-based process	Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.		hp.json		http://purl.obolibrary.org/obo/GO_0007017		goslim_chembl
HP:0031760	biolink:PhenotypicFeature	Non-accomodative esotropia	A form of esotropia in which the angle of deviation is not affected by accommodative effort.		hp.json		http://purl.obolibrary.org/obo/HP_0031760		
GO:0010668	biolink:BiologicalProcess	ectodermal cell differentiation	The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0010668		
HP:0031761	biolink:PhenotypicFeature	Infantile constant esotropia	Constant esotropia occurring before 6 months of age. It is typically associated with a large angle of deviation, alternating fixation (therefore low risk of amblyopia) and poor potential for binocular single vision. Other features that might be present in individuals with infantile (constant) esotropia include latent nystagmus or manifest latent nystagmus, dissociated vertical divergence, cyclotropia, abnormal head posture, limited abduction.		hp.json	Infantile (constant) esotropia	http://purl.obolibrary.org/obo/HP_0031761		
HP:0031762	biolink:PhenotypicFeature	Distance esotropia	An intermittent esotropia where binocular single vision is present on near fixation and an esotropia on distance fixation. Often associated with myopia and aging.		hp.json	Divergence insufficiency	http://purl.obolibrary.org/obo/HP_0031762		
GO:0010666	biolink:BiologicalProcess	positive regulation of cardiac muscle cell apoptotic process	Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.		hp.json	positive regulation of cardiac muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010666		
GO:0034637	biolink:NamedThing	cellular carbohydrate biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0034637		
GO:0010667	biolink:BiologicalProcess	negative regulation of cardiac muscle cell apoptotic process	Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.		hp.json	down-regulation of cardiac muscle cell apoptosis|negative regulation of cardiac muscle cell apoptosis|down regulation of cardiac muscle cell apoptosis|inhibition of cardiac muscle cell apoptosis|downregulation of cardiac muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010667		
HP:0031763	biolink:PhenotypicFeature	Cyclic esotropia	Convergent strabismus in which normal binocular single vision is alternating with large angle esotropia in rhythmic cycle.		hp.json		http://purl.obolibrary.org/obo/HP_0031763		
GO:0007010	biolink:BiologicalProcess	cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.		hp.json	cytoskeletal regulator activity|cytoskeleton organisation|cytoskeleton organization and biogenesis|cytoskeletal organization and biogenesis	http://purl.obolibrary.org/obo/GO_0007010		goslim_yeast|goslim_generic|goslim_candida|goslim_drosophila|goslim_chembl|goslim_aspergillus
HP:0031768	biolink:PhenotypicFeature	Parafoveal fixation	Fixation of an object in the area adjacent to the fovea.		hp.json		http://purl.obolibrary.org/obo/HP_0031768		
GO:0010660	biolink:BiologicalProcess	regulation of muscle cell apoptotic process	Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.		hp.json	regulation of muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010660		
HP:0031769	biolink:PhenotypicFeature	Peripheral fixation	Fixation of an object in a peripheral area of the retina.		hp.json		http://purl.obolibrary.org/obo/HP_0031769		
GO:0010661	biolink:BiologicalProcess	positive regulation of muscle cell apoptotic process	Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death.		hp.json	positive regulation of muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010661		
HP:0031764	biolink:PhenotypicFeature	Fully accomodative esotropia	Esotropia in which normal binocular single vision is present for all distances when the hypermetropic refractive error is corrected. Esotropia is present for near and distance on accommodation without correction.		hp.json		http://purl.obolibrary.org/obo/HP_0031764		
GO:0010664	biolink:BiologicalProcess	negative regulation of striated muscle cell apoptotic process	Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.		hp.json	downregulation of striated muscle cell apoptosis|down regulation of striated muscle cell apoptosis|inhibition of striated muscle cell apoptosis|down-regulation of striated muscle cell apoptosis|negative regulation of striated muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010664		
HP:0031765	biolink:PhenotypicFeature	Partially accomodative esotropia	A form of constant esotropia in which the angle of deviation is partially affected by accommodative effort. Typically there is esotropia at near and distance with hypermetropic correction and the angle of deviation increases without glasses.		hp.json	Constant esotropia with an accommodative component|Constant esotropia with an accommodative element	http://purl.obolibrary.org/obo/HP_0031765		
GO:0010665	biolink:BiologicalProcess	regulation of cardiac muscle cell apoptotic process	Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.		hp.json	regulation of cardiac muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010665		
HP:0031766	biolink:PhenotypicFeature	Convergence excess esotropia	An intermittent esotropia with binocular single vision present at distance fixation but esotropia on accommodation for near fixation. Usually associated with hypermetropia but patients can be emmetropic and rarely myopic. Associated with a high accommodative convergence/accommodation (AC/A) ratio.		hp.json		http://purl.obolibrary.org/obo/HP_0031766		
GO:0010662	biolink:BiologicalProcess	regulation of striated muscle cell apoptotic process	Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.		hp.json	regulation of striated muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010662		
HP:0031767	biolink:PhenotypicFeature	Consecutive esotropia	Esotropia in a patient who has previously had exotropia or exophoria; may be constant or intermittent and usually follows surgical overcorrection.		hp.json		http://purl.obolibrary.org/obo/HP_0031767		
GO:0010663	biolink:BiologicalProcess	positive regulation of striated muscle cell apoptotic process	Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death.		hp.json	positive regulation of striated muscle cell apoptosis	http://purl.obolibrary.org/obo/GO_0010663		
HP:0004174	biolink:PhenotypicFeature	obsolete Accessory middle phalanx of middle finger			hp.json		http://purl.obolibrary.org/obo/HP_0004174		
NBO:0000244	biolink:NamedThing	pathological anxiety			hp.json	hysteria|pathological anxiety disorder	http://purl.obolibrary.org/obo/NBO_0000244		
HP:0004172	biolink:PhenotypicFeature	Abnormality of the middle phalanx of the 3rd finger		UMLS:C4025410	hp.json	Abnormal middle finger bone of the middle finger	http://purl.obolibrary.org/obo/HP_0004172		
NBO:0000243	biolink:NamedThing	behavioral phenotype	"An observable characteristic of the behavior of an organism." [NBO:RH]		hp.json		http://purl.obolibrary.org/obo/NBO_0000243		
HP:0004175	biolink:PhenotypicFeature	obsolete Periosteal new bone of middle phalanx of middle-finger			hp.json		http://purl.obolibrary.org/obo/HP_0004175		
HP:0004192	biolink:PhenotypicFeature	obsolete Bracket epiphyses of the 4th finger			hp.json		http://purl.obolibrary.org/obo/HP_0004192		
NBO:0000248	biolink:NamedThing	obsessive-compulsive disorder	"A pathological anxiety primarily characterized by repetitive obsessions (distressing, persistent, and intrusive thoughts or images) and compulsions (urges to perform specific acts or rituals)." [wikipedia:Obsessive%E2%80%93compulsive_disorder]		hp.json	OCD	http://purl.obolibrary.org/obo/NBO_0000248		
GO:0007028	biolink:BiologicalProcess	cytoplasm organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.		hp.json	cytoplasm organisation|cytoplasm organization and biogenesis	http://purl.obolibrary.org/obo/GO_0007028		goslim_pir
NBO:0000246	biolink:NamedThing	phobia	"A pathological anxiety characterized by fear or anxiety triggered by a specific stimulus or situation." [NBO:GVG]		hp.json	phobic disorder	http://purl.obolibrary.org/obo/NBO_0000246		
GO:0007027	biolink:BiologicalProcess	negative regulation of axonemal microtubule depolymerization	Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme.		hp.json	axonemal microtubule stabilization|negative regulation of microtubule depolymerization in axoneme	http://purl.obolibrary.org/obo/GO_0007027		
HP:0031771	biolink:PhenotypicFeature	Epicanthus tarsalis	A type of epicanthus in which a primarily upper lid fold is present.		hp.json		http://purl.obolibrary.org/obo/HP_0031771		
GO:0007026	biolink:BiologicalProcess	negative regulation of microtubule depolymerization	Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.		hp.json	microtubule stabilization|downregulation of microtubule depolymerization|down regulation of microtubule depolymerization|negative regulation of microtubule disassembly|negative regulation of microtubule catastrophe|inhibition of microtubule depolymerization|down-regulation of microtubule depolymerization|microtubule rescue	http://purl.obolibrary.org/obo/GO_0007026		
UBERON:8400024	biolink:AnatomicalEntity	subcapsular region of liver	Region of liver parenchyma immediately below the capsule. This region is frequently specified in pathology diagnoses.		hp.json	liver subcapsular tissue|liver subcapsular region|subcapsular tissue of liver	http://purl.obolibrary.org/obo/UBERON_8400024		
HP:0031772	biolink:PhenotypicFeature	Abnormal posterior circulating artery morphology	Any structural anomaly of the posterior circulating artery (PCOM).		hp.json		http://purl.obolibrary.org/obo/HP_0031772		
HP:0031773	biolink:PhenotypicFeature	Posterior communicating artery aneurysm	A widening (ballooning) localized in the wall of the posterior communicating artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031773		
GO:0010677	biolink:BiologicalProcess	negative regulation of cellular carbohydrate metabolic process	Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.		hp.json		http://purl.obolibrary.org/obo/GO_0010677		
HP:0031774	biolink:PhenotypicFeature	Posterior communicating artery infundibulum	A funnel-shaped symmetrical enlargement of the origin of the posterior communicating artery at its junction with the internal carotid artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031774		
GO:0007020	biolink:BiologicalProcess	microtubule nucleation	The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).	Wikipedia:Microtubule_nucleation	hp.json		http://purl.obolibrary.org/obo/GO_0007020		
HP:0031770	biolink:PhenotypicFeature	Epicanthus palpebralis	A type of epicanthus in which a medial vertical fold is present between upper and lower lids.		hp.json		http://purl.obolibrary.org/obo/HP_0031770		
HP:0031779	biolink:PhenotypicFeature	Excyclophoria	A type of cyclophoria (latent strabismus in which the occluded eye wheel-rotates on dissociation.) in which the upper poles of the globes are rotated outward (laterally) to each other.		hp.json		http://purl.obolibrary.org/obo/HP_0031779		
GO:0007030	biolink:BiologicalProcess	Golgi organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.		hp.json	Golgi organisation|Golgi organization and biogenesis	http://purl.obolibrary.org/obo/GO_0007030		goslim_pir
GO:0010675	biolink:BiologicalProcess	regulation of cellular carbohydrate metabolic process	Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.		hp.json		http://purl.obolibrary.org/obo/GO_0010675		
HP:0031775	biolink:PhenotypicFeature	Neurogenic strabismus	An ocular deviation caused by a palsy to one or more of the extraocular muscles or nerves supplying them.		hp.json	Paralytic strabismus	http://purl.obolibrary.org/obo/HP_0031775		
HP:0031776	biolink:PhenotypicFeature	Cyclotropia	A form of manifest strabismus (heterotropia) in which the one eye is wheel rotated so that the upper end of its vertical axis is nasal (incyclotropia) or temporal (excyclotropia).		hp.json		http://purl.obolibrary.org/obo/HP_0031776		
GO:0010676	biolink:BiologicalProcess	positive regulation of cellular carbohydrate metabolic process	Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.		hp.json		http://purl.obolibrary.org/obo/GO_0010676		
HP:0031777	biolink:PhenotypicFeature	Cyclophoria	A form of latent strabismus (heterophoria) in which the occluded eye wheel-rotates on dissociation.		hp.json		http://purl.obolibrary.org/obo/HP_0031777		
HP:0031778	biolink:PhenotypicFeature	Incyclophoria	A type of cyclophoria (latent strabismus in which the occluded eye wheel-rotates on dissociation.) in which the upper poles of the globes are rotated inward (medially) to each other.		hp.json		http://purl.obolibrary.org/obo/HP_0031778		
CHEBI:140325	biolink:ChemicalSubstance	secondary carboxamide	A carboxamide resulting from the formal condensation of a carboxylic acid with a primary amine; formula RC(=O)NHR(1).		hp.json	secondary carboxamides	http://purl.obolibrary.org/obo/CHEBI_140325		3_STAR
NBO:0000256	biolink:NamedThing	mood disorder			hp.json		http://purl.obolibrary.org/obo/NBO_0000256		
HP:0004185	biolink:PhenotypicFeature	obsolete Fused epiphysis of terminal phalanx of the middle finger			hp.json		http://purl.obolibrary.org/obo/HP_0004185		
HP:0004184	biolink:PhenotypicFeature	obsolete Cone-shaped epiphysis of terminal phalanx of the middle finger			hp.json		http://purl.obolibrary.org/obo/HP_0004184		
HP:0004183	biolink:PhenotypicFeature	obsolete Abnormality of the epiphyses of the terminal phalanx of the middle finger			hp.json		http://purl.obolibrary.org/obo/HP_0004183		
HP:0004188	biolink:PhenotypicFeature	Abnormal 4th finger morphology		UMLS:C4021680	hp.json	Abnormality of the ring finger|Abnormality of the 4th finger	http://purl.obolibrary.org/obo/HP_0004188		
HP:0004187	biolink:PhenotypicFeature	obsolete Prematurely fused epiphysis of terminal phalanx of the middle finger			hp.json		http://purl.obolibrary.org/obo/HP_0004187		
HP:0004186	biolink:PhenotypicFeature	obsolete Large epiphysis of terminal phalanx of the middle finger			hp.json		http://purl.obolibrary.org/obo/HP_0004186		
HP:0006739	biolink:PhenotypicFeature	Squamous cell carcinoma of the skin	Squamous cell carcinoma of the skin is a malignant tumor of squamous epithelium.	UMLS:C0553723|SNOMEDCT_US:254651007	hp.json	Squamous skin carcinoma	http://purl.obolibrary.org/obo/HP_0006739		
CHEBI:35819	biolink:ChemicalSubstance	branched-chain fatty acid	Any fatty acid in which the parent hydrocarbon chain has one or more alkyl substituents; a common component in animal and bacterial lipids. The fatty acyl chain is usually saturated and the substituent a methyl group; however, unsaturated BCFAs are found in marine animals, and branches other than methyl are found in microbial lipids.	KEGG:C05996|PMID:18318842	hp.json	branched fatty acid|BCFA|branched-chain fatty acids|BCFAs|branched fatty acids|Branched chain fatty acid	http://purl.obolibrary.org/obo/CHEBI_35819		3_STAR
HP:0006735	biolink:PhenotypicFeature	Renal cortical adenoma	The presence of an adenoma in the cortex of the kidney.	UMLS:C0346253|SNOMEDCT_US:254919009|NCIT:C2855	hp.json	Kidney cortical adenoma	http://purl.obolibrary.org/obo/HP_0006735		
HP:0031702	biolink:PhenotypicFeature	Anterior chamber red blood cells	The presence of erythrocyte in the aqueous humor of the anterior chamber of the eye.		hp.json	Anterior chamber RBCs	http://purl.obolibrary.org/obo/HP_0031702		
HP:0031703	biolink:PhenotypicFeature	Abnormal ear morphology	Any structural anomaly of the ear.	Fyler:4867	hp.json		http://purl.obolibrary.org/obo/HP_0031703		
HP:0006737	biolink:PhenotypicFeature	Extraadrenal pheochromocytoma	Pheochromocytoma not originating from the adrenal medulla but from another source such as from chromaffin cells in or about sympathetic ganglia.	UMLS:C1257877|MSH:D010673	hp.json	Pheochromocytoma, extraadrenal	http://purl.obolibrary.org/obo/HP_0006737		
HP:0031704	biolink:PhenotypicFeature	Abnormal ear physiology	Any functional anomaly of the ear.		hp.json		http://purl.obolibrary.org/obo/HP_0031704		
HP:0031705	biolink:PhenotypicFeature	Compensatory head posture	A compensatory head posture occurs when the head is deviated out of the normal primary straight head position in order to compensate for an ocular problem.		hp.json		http://purl.obolibrary.org/obo/HP_0031705		
HP:0006731	biolink:PhenotypicFeature	Follicular thyroid carcinoma	The presence of an follicular adenocarcinoma of the thyroid gland.	SNOMEDCT_US:255028004|SNOMEDCT_US:28173006|MSH:D018263|SNOMEDCT_US:5257006|NCIT:C8054|UMLS:C0206682	hp.json		http://purl.obolibrary.org/obo/HP_0006731		
HP:0006732	biolink:PhenotypicFeature	Papillary renal cell carcinoma type 2	A type of papillary renal cell carcinoma in which the papillae are covered by large eosinophilic cells with pleomorphic nuclei, prominent nucleoli, and nuclear pseudostratification.	UMLS:C1336840	hp.json		http://purl.obolibrary.org/obo/HP_0006732		
HP:0006733	biolink:PhenotypicFeature	Acute megakaryocytic leukemia	A rare subtype of acute myeloid leukemia evolving from primitive megakaryoblasts.	UMLS:C0023467|SNOMEDCT_US:17788007|SNOMEDCT_US:413443009|MSH:D015470|SNOMEDCT_US:91861009	hp.json	AMegL|Acute megakaryocytic leukaemia	http://purl.obolibrary.org/obo/HP_0006733		
HP:0031700	biolink:PhenotypicFeature	Invasive parasitic infection	A parasitic infection whereby the parasite invades (migrates through) tissues of the infected host.		hp.json		http://purl.obolibrary.org/obo/HP_0031700		
HP:0031701	biolink:PhenotypicFeature	Anterior chamber inflammatory cells	The presence of inflammatory cells in the aqueous humor of the anterior chamber of the eye.		hp.json		http://purl.obolibrary.org/obo/HP_0031701		
HP:0031706	biolink:PhenotypicFeature	Compensatory chin depression	A tendency to hold the chin depressed (lowered) to compensate for a limitation of eye movement.		hp.json		http://purl.obolibrary.org/obo/HP_0031706		
HP:0031707	biolink:PhenotypicFeature	Compensatory face turn to the right	A tendency to turn the face to the right to compensate for a limitation of eye movement.		hp.json		http://purl.obolibrary.org/obo/HP_0031707		
HP:0031708	biolink:PhenotypicFeature	Compensatory face turn to the left	A tendency to turn the face to the left to compensate for a limitation of eye movement.		hp.json		http://purl.obolibrary.org/obo/HP_0031708		
HP:0031709	biolink:PhenotypicFeature	Compensatory head tilt to the right shoulder	A tendency to tilt the head towards the right shoulder to compensate for a limitation of eye movement.		hp.json		http://purl.obolibrary.org/obo/HP_0031709		
CHEBI:35825	biolink:ChemicalSubstance	mandelic acid	A 2-hydroxy monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by phenyl and hydroxyl groups.	Reaxys:510011|Wikipedia:Mandelic_acid|Drug_Central:1629|PMID:24278065|CAS:90-64-2|PMID:4813698|CAS:90-64-2|Gmelin:218213|Beilstein:510011|PMID:22770225|HMDB:HMDB0000703	hp.json	(RS)-Mandelic acid|2-Hydroxy-2-phenylethanoic acid|hydroxy(phenyl)acetic acid|Mandelsaeure|DL-Mandelic acid|2-Hydroxy-2-phenylacetic acid|alpha-hydroxybenzeneacetic acid	http://purl.obolibrary.org/obo/CHEBI_35825		3_STAR
HP:0031713	biolink:PhenotypicFeature	Constant exotropia	A form of divergent strabismus (exotropia) in which the eye turns outward at all distances and at all times.		hp.json		http://purl.obolibrary.org/obo/HP_0031713		
HP:0031714	biolink:PhenotypicFeature	Distance exotropia	A type of divergent strabismus (exotropia) in which an eye tends to turn outwards (i.e., the eye squints) mainly when looking at distant objects. The eyes tend to remain straight when they look at near objects. Distance exotropia may be constant or intermittent.		hp.json		http://purl.obolibrary.org/obo/HP_0031714		
HP:0006747	biolink:PhenotypicFeature	Ganglioneuroblastoma		SNOMEDCT_US:69515008|SNOMEDCT_US:116381000119105|UMLS:C0206718|MSH:D018305	hp.json		http://purl.obolibrary.org/obo/HP_0006747		
HP:0006748	biolink:PhenotypicFeature	Adrenal pheochromocytoma	Pheochromocytoma originating from the adrenal medulla.	SNOMEDCT_US:85583005|SNOMEDCT_US:399343007|UMLS:C0031511|MSH:D010673|SNOMEDCT_US:302835009|NCIT:C3326	hp.json	Pheochromocytomas, adrenal|Pheochromocytoma, adrenal	http://purl.obolibrary.org/obo/HP_0006748		
HP:0031715	biolink:PhenotypicFeature	Near exotropia	An intermittent exotropia where there is binocular single vision on distance fixation and exotropia at near (intermittent or constant).		hp.json		http://purl.obolibrary.org/obo/HP_0031715		
HP:0006749	biolink:PhenotypicFeature	Malignant gastrointestinal tract tumors		SNOMEDCT_US:428905002|MSH:D005770|UMLS:C0685938	hp.json	Malignant GI tract tumours|Malignant GI tract tumors|Malignant gastrointestinal tract tumours	http://purl.obolibrary.org/obo/HP_0006749		
HP:0031716	biolink:PhenotypicFeature	Cyclic exotropia	A type of exotropia (divergent strabismus) in which binocular single vision alternates with large angle exotropia in rhythmic cycle.		hp.json		http://purl.obolibrary.org/obo/HP_0031716		
CHEBI:35821	biolink:ChemicalSubstance	anticholesteremic drug	A substance used to lower plasma cholesterol levels.		hp.json	antihypercholesterolemic agents|cholesterol inhibitor|hypocholesteremic agent|antihypercholesterolemic|anticholesteremic agent|cholesterol-lowering agent|anticholesteremic drugs|cholesterol-lowering drugs|anticholesteremic|cholesterol-lowering drug|cholesterol-lowering agents|antihypercholesterolemics|antihypercholesterolemic agent|antihypercholesterolemic drug|antihypercholesterolemic drugs	http://purl.obolibrary.org/obo/CHEBI_35821		3_STAR
HP:0006742	biolink:PhenotypicFeature	Congenital neuroblastoma		UMLS:C4024986	hp.json		http://purl.obolibrary.org/obo/HP_0006742		
HP:0006743	biolink:PhenotypicFeature	Embryonal rhabdomyosarcoma		SNOMEDCT_US:14269005|SNOMEDCT_US:404051002|UMLS:C0206656|MSH:D018233|NCIT:C8971	hp.json		http://purl.obolibrary.org/obo/HP_0006743		
HP:0031710	biolink:PhenotypicFeature	Compensatory head tilt to the left shoulder	A tendency to tilt the head towards the left shoulder to compensate for a limitation of eye movement.		hp.json		http://purl.obolibrary.org/obo/HP_0031710		
HP:0006744	biolink:PhenotypicFeature	Adrenocortical carcinoma	A malignant neoplasm of the adrenal cortex that may produce hormones such as cortisol, aldosterone, estrogen, or testosterone.	MSH:D018268|NCIT:C2916|UMLS:C0206686|SNOMEDCT_US:255035007|SNOMEDCT_US:2227007	hp.json	Adrenal gland carinoma|Adrenal carcinoma	http://purl.obolibrary.org/obo/HP_0006744		
HP:0031711	biolink:PhenotypicFeature	Asymmetric abdominal aortic aneurysm	An abdominal aortic aneurysm that is not symmetric around its axis (not axisymmetric).		hp.json		http://purl.obolibrary.org/obo/HP_0031711		
HP:0006740	biolink:PhenotypicFeature	Transitional cell carcinoma of the bladder	The presence of a carcinoma of the urinary bladder with origin in a transitional epithelial cell.	UMLS:C0279680|NCIT:C2930|SNOMEDCT_US:255109008	hp.json	Transitional cell bladder carcinoma	http://purl.obolibrary.org/obo/HP_0006740		
HP:0031717	biolink:PhenotypicFeature	Alternating exotropia	A type of exotropia in which either eye may be used for fixation.		hp.json	Alternating strabismus	http://purl.obolibrary.org/obo/HP_0031717		
HP:0031718	biolink:PhenotypicFeature	Consecutive exotropia	Exotropia in an individual who has previously had esotropia or esophoria.		hp.json		http://purl.obolibrary.org/obo/HP_0031718		
CHEBI:23849	biolink:ChemicalSubstance	diterpenoid	Any terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).	LIPID_MAPS_class:LMPR0104	hp.json	diterpenoides|C20 isoprenoids|diterpenoids	http://purl.obolibrary.org/obo/CHEBI_23849		3_STAR
HP:0031719	biolink:PhenotypicFeature	True distance exotropia	Exotropia (intermittent or constant) on distance fixation with binocular single vision on near fixation under all testing conditions. The accommodative convergence/accommodation (AC:A) ratio is within normal limits.		hp.json		http://purl.obolibrary.org/obo/HP_0031719		
HP:0006717	biolink:PhenotypicFeature	Peripheral neuroepithelioma		UMLS:C3489398|SNOMEDCT_US:254764001	hp.json		http://purl.obolibrary.org/obo/HP_0006717		
HP:0006719	biolink:PhenotypicFeature	Benign gastrointestinal tract tumors		UMLS:C0497538|SNOMEDCT_US:92118007	hp.json	Benign gastrointestinal tract tumours|Benign GI tract tumors|Non-cancerous GI tumours|Non-cancerous GI tumors|Benign GI tract tumours	http://purl.obolibrary.org/obo/HP_0006719		
HP:0006713	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the scapulae		UMLS:C4024991	hp.json	Absent/small shoulder blade|Absent/underdeveloped shoulder blade	http://purl.obolibrary.org/obo/HP_0006713		
HP:0031724	biolink:PhenotypicFeature	Microtropia	A small angle heterotropia (usually of 10 diopters or less) in which a form of binocular single vision occurs.		hp.json		http://purl.obolibrary.org/obo/HP_0031724		
HP:0006714	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the sternum		UMLS:C4024990	hp.json	Absent/underdeveloped sternum|Absent/small sternum	http://purl.obolibrary.org/obo/HP_0006714		
HP:0031725	biolink:PhenotypicFeature	Hypophoria	A form of latent strabismus (heterophoria) in which, on dissociation, the occluded eye deviates downwards.		hp.json		http://purl.obolibrary.org/obo/HP_0031725		
HP:0031726	biolink:PhenotypicFeature	Incyclotropia	A type of cyclotropia (torsion of one or both eye around the visual axis of the eyes) in which the upper poles of the globes are rotated inward (medially) to each other.		hp.json		http://purl.obolibrary.org/obo/HP_0031726		
HP:0006715	biolink:PhenotypicFeature	Glomus tympanicum paraganglioma		UMLS:C1866555	hp.json	Tympanic nerve tumours|Tympanic nerve tumors|Tympanic nerve tumor|Tympanic nerve tumour	http://purl.obolibrary.org/obo/HP_0006715		
HP:0031727	biolink:PhenotypicFeature	Excyclotropia	A type of cyclotropia (torsion of one or both eye around the visual axis of the eyes) in which the upper poles of the globes are rotated outward (laterally) to each other.		hp.json		http://purl.obolibrary.org/obo/HP_0031727		
HP:0006716	biolink:PhenotypicFeature	Hereditary nonpolyposis colorectal carcinoma		UMLS:C4024989	hp.json		http://purl.obolibrary.org/obo/HP_0006716		
HP:0031720	biolink:PhenotypicFeature	Simulated distance exotropia	Exotropia (intermittent or constant) worse for distance fixation in which the near angle of deviation increases (or near exophoria becomes exotropia) with: (1) prolonged disruption of fusion and/or (2) elimination of accommodation.		hp.json		http://purl.obolibrary.org/obo/HP_0031720		
HP:0006710	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the clavicles	Absence or underdevelopment of the clavicles (collar bones).	UMLS:C4024993	hp.json	Absent/small collarbone|Absent/underdeveloped collarbone	http://purl.obolibrary.org/obo/HP_0006710		
HP:0031721	biolink:PhenotypicFeature	Sensory exotropia	A type of divergent strabismus (exotropia) that develops in a poorly seeing eye.		hp.json	Secondary exotropia	http://purl.obolibrary.org/obo/HP_0031721		
HP:0006711	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving bones of the thorax		UMLS:C4024992	hp.json	Absent/small outermost thorax bone|Absent/underdeveloped thorax bone	http://purl.obolibrary.org/obo/HP_0006711		
HP:0031722	biolink:PhenotypicFeature	Near esotropia	An intermittent esotropia where there is binocular single vision on distance fixation and esotropia at near even when the accommodation is relieved.		hp.json	Non-accomodative convergence excess esotropia	http://purl.obolibrary.org/obo/HP_0031722		
PR:P09581	biolink:Protein	macrophage colony-stimulating factor 1 receptor (mouse)	A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of mouse.	UniProtKB:P09581	hp.json	CSF-1 receptor (mouse)|Fms|CSF-1-R (mouse)|Csfmr|mCSF1R|M-CSF-R (mouse)|Csf1r|CSF-1R (mouse)|proto-oncogene c-Fms (mouse)|CD115 (mouse)	http://purl.obolibrary.org/obo/PR_P09581		
HP:0006712	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the ribs		UMLS:C1847363	hp.json	Absent/small ribs|Hypoplastic or missing ribs|Absent/underdeveloped ribs	http://purl.obolibrary.org/obo/HP_0006712		
HP:0031723	biolink:PhenotypicFeature	Secondary esotropia	Convergent squint which follows loss or impairment of vision.		hp.json	Sensory esotropia	http://purl.obolibrary.org/obo/HP_0031723		
OBO:nbo#has-input	biolink:NamedThing	has-input			hp.json		http://purl.obolibrary.org/obo/nbo#has-input		
HP:0031728	biolink:PhenotypicFeature	Mild hypermetropia	A form of hypermetropia with not more than +2.00 diopters.		hp.json	Mild hyperopia	http://purl.obolibrary.org/obo/HP_0031728		
HP:0031729	biolink:PhenotypicFeature	Moderate hypermetropia	A form of hypermetropia with more than +2.00 diopters but not more than +5.00 diopters.		hp.json	Moderate hyperopia	http://purl.obolibrary.org/obo/HP_0031729		
CHEBI:35804	biolink:ChemicalSubstance	citrate(1-)	A tricarboxylic acid monoanion that is the conjugate base of citric acid, obtained by deprotonation of one of the three carboxy groups.		hp.json	H2cit|dihydrogen citrate|H2cit(-)	http://purl.obolibrary.org/obo/CHEBI_35804		3_STAR
HP:0031730	biolink:PhenotypicFeature	Axial myopia	A form of myopia related to an axial length above the norm and too long for the refractive power of the whole optical system of the eye.		hp.json		http://purl.obolibrary.org/obo/HP_0031730		
HP:0006729	biolink:PhenotypicFeature	Retroperitoneal chemodectomas		NCIT:C3308|UMLS:C4024987	hp.json		http://purl.obolibrary.org/obo/HP_0006729		
CHEBI:35808	biolink:ChemicalSubstance	citrate(2-)	A tricarboxylic acid dianion obtained by deprotonation of two of the three carboxy groups of citric acid.		hp.json	hydrogen citrate|Hcit(2-)|Hcit	http://purl.obolibrary.org/obo/CHEBI_35808		3_STAR
UBERON:0002294	biolink:AnatomicalEntity	biliary system	Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree).	MESH:D001659|GAID:279|NCIT:C12678|MA:0001273|FMA:79646	hp.json	biliary apparatus|biliary tract	http://purl.obolibrary.org/obo/UBERON_0002294		uberon_slim|pheno_slim
HP:0006725	biolink:PhenotypicFeature	Pancreatic adenocarcinoma	The presence of an adenocarcinoma of the pancreas.	SNOMEDCT_US:700423003|NCIT:C2852|UMLS:C0281361	hp.json		http://purl.obolibrary.org/obo/HP_0006725		
UBERON:0002293	biolink:AnatomicalEntity	costochondral joint	A bars of hyaline cartilage located between the distal part of a rib and a costal cartilage, connecting the ribs to the sternum .	UMLS:C0224683|OpenCyc:Mx4rvfy27JwpEbGdrcN5Y29ycA|EMAPA:36490|MA:0001509|NCIT:C32392|FMA:7956	hp.json	costochondral junction|chondrocostal synchondrosis|articulatio costochondralis|costochondral synchondrosis|articulationes costochondrales	http://purl.obolibrary.org/obo/UBERON_0002293		uberon_slim|pheno_slim
HP:0031736	biolink:PhenotypicFeature	Involutional entropion	An abnormal inversion of the eyelid towards the globe resulting from inferior retractor muscle dysfunction with tissue laxity and, possibly, overriding of the preseptal orbicularis muscle over the pretarsal orbicularis muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031736		
UBERON:0002296	biolink:AnatomicalEntity	dorsal mesentery	The mesentery that originates from the dorsal side of the peritoneal cavity[ZFA].	EHDAA2:0004560|TAO:0005130|FMA:79795|EHDAA:3957|EHDAA:3934|EHDAA:3921|EHDAA:3019|EHDAA:3971|EHDAA:3033|ZFA:0005130	hp.json	mesenterium dorsale commune|dorsal mesogastrium	http://purl.obolibrary.org/obo/UBERON_0002296		uberon_slim|vertebrate_core
HP:0031737	biolink:PhenotypicFeature	Cicatricial entropion	Abnormal inversion (turning inward) of the eyelid towards the globe associated with scarring that vertically shortens the posterior lamella of the eyelid.		hp.json		http://purl.obolibrary.org/obo/HP_0031737		
HP:0031738	biolink:PhenotypicFeature	Mechanical entropion	A type of entropion (abnormal inversion of the eyelid towards the globe) that is related to a mass effect of a lesion (e.g., a tumor) that pulls the eyelid margin away from the globe.		hp.json		http://purl.obolibrary.org/obo/HP_0031738		
HP:0006727	biolink:PhenotypicFeature	T-cell acute lymphoblastic leukemias	Acute lymphoblastic leukemia of T-cell origin. It comprises about 15% of childhood cases and 25% of adult cases. It is more common in males than females.	SNOMEDCT_US:128824003|MSH:D054218|UMLS:C1961099|SNOMEDCT_US:277575008	hp.json		http://purl.obolibrary.org/obo/HP_0006727		
UBERON:0002290	biolink:AnatomicalEntity	choroid plexus of fourth ventricle	Choroid plexus of the fourth ventricle.	VHOG:0001375|ZFA:0001446|HBA:9710|MA:0000983|NLX:27388|BAMS:chp4|TAO:0001446|FMA:78492|DHBA:12808|UMLS:C0152293|EMAPA:32742|BAMS:cp4v|NCIT:C32308	hp.json	fourth ventricle choroid plexus|choroid plexus fourth ventricle|fourth ventricle chorioid plexus of cerebral hemisphere|4th ventricle choroid plexus|chorioid plexus of cerebral hemisphere of fourth ventricle|chorioid plexus of fourth ventricle	http://purl.obolibrary.org/obo/UBERON_0002290		vertebrate_core
HP:0031731	biolink:PhenotypicFeature	Increased tear production	Increased lacrimation owing to overproduction of tears.		hp.json		http://purl.obolibrary.org/obo/HP_0031731		
HP:0006721	biolink:PhenotypicFeature	Acute lymphoblastic leukemia	A form of acute leukemia characterized by excess lympoblasts.	SNOMEDCT_US:128822004|SNOMEDCT_US:91857003|UMLS:C0023449	hp.json	Acute lymphatic leukaemia|Acute lymphocytic leukemia|Acute lymphocytic leukaemia|Acute lymphatic leukemia|Acute lymphoid leukemia|Acute lymphoblastic leukaemia|Acute lymphoid leukaemia	http://purl.obolibrary.org/obo/HP_0006721		
HP:0031732	biolink:PhenotypicFeature	Increased basal tear production	A form of watery eye associated with overproduction of tears due to an increased parasympathetic drive to the secretory component of the lacrimal system (lacrimal gland); this could be due to pro-secretory drug use (e.g. pilocarpine) or autonomic disturbance.		hp.json		http://purl.obolibrary.org/obo/HP_0031732		
HP:0006722	biolink:PhenotypicFeature	Small intestine carcinoid		UMLS:C1868072	hp.json		http://purl.obolibrary.org/obo/HP_0006722		
HP:0031733	biolink:PhenotypicFeature	Reflex tearing	A form of watery eye associated with overproduction of tears due to reflex tearing in response to a local irritant (e.g. trichiasis or foreign body), chronic ocular surface disease (e.g. blepharitis) or systemic disease (e.g. thyroid eye disease).		hp.json		http://purl.obolibrary.org/obo/HP_0031733		
UBERON:0002291	biolink:AnatomicalEntity	central canal of spinal cord	Spinal cord structure that is part of the ventricular system and is filled with cerebral-spinal fluid and runs the length of the spinal cord.	MA:0001117|HBA:9422|DMBA:126652042|BAMS:C|UMLS:C0459414|BIRNLEX:1409|ZFA:0000938|EMAPA:35789|TAO:0000938|NCIT:C12891|BAMS:CC|DHBA:146035108|EHDAA2:0004361|FMA:78497|MBA:164	hp.json	spinal cord central canal|canalis centralis|central canal|ventricle of spinal cord|central canal of spinal cord|central canal, spinal cord/medulla	http://purl.obolibrary.org/obo/UBERON_0002291		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas
HP:0031734	biolink:PhenotypicFeature	Lacrimal pump failure	A form of watery eye associated with abnormal lid tone and/or lid position. The former is due to lid laxity (common involutional change in the elderly) or a weak orbicularis muscle (e.g. due to VII cranial nerve palsy). The latter is typically associated with ectropion causing punctal eversion.		hp.json		http://purl.obolibrary.org/obo/HP_0031734		
HP:0006723	biolink:PhenotypicFeature	Intestinal carcinoid		UMLS:C4024988	hp.json		http://purl.obolibrary.org/obo/HP_0006723		
CHEBI:23824	biolink:ChemicalSubstance	diol	A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.	Wikipedia:Diol	hp.json	diols	http://purl.obolibrary.org/obo/CHEBI_23824		3_STAR
UBERON:0002298	biolink:AnatomicalEntity	brainstem	Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized].	MBA:343|UMLS:C0006121|BIRNLEX:1565|MESH:D001933|MA:0000169|UMLS:C0006121|Wikipedia:Brainstem|SCTID:180925009|EMAPA:32678|EFO:0001962|ZFA:0001707|CALOHA:TS-0093|TAO:0002156|NCIT:C12441|BAMS:BS|BTO:0000146|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=236|FMA:79876|VHOG:0001457|EV:0100241	hp.json	accessory medullary lamina of pallidum|truncus encephali|lamina medullaris accessoria|truncus encephali|brain stem|truncus encephalicus|lamina pallidi incompleta|lamella pallidi incompleta|lamina medullaris incompleta pallidi	http://purl.obolibrary.org/obo/UBERON_0002298		uberon_slim|vertebrate_core|pheno_slim|efo_slim
HP:0031739	biolink:PhenotypicFeature	Abnormal oblique muscle physiology	A functional anomaly of the inferior or superior oblique muscle.		hp.json		http://purl.obolibrary.org/obo/HP_0031739		
UBERON:0002299	biolink:AnatomicalEntity	alveolus of lung	Spherical outcropping of the respiratory bronchioles and primary site of gas exchange with the blood. Alveoli are particular to mammalian lungs. Different structures are involved in gas exchange in other vertebrates[WP].	VHOG:0001445|FMA:7318|GAID:349|EMAPA:32682|BTO:0000060|MA:0000420|CALOHA:TS-0031|EFO:0001985|MESH:D011650|EV:0100043	hp.json	alveolus pulmonis|lung alveolus|pulmonary alveolus|respiratory alveoli|alveolus pulmonis|respiratory alveolus|alveoli|alveolus	http://purl.obolibrary.org/obo/UBERON_0002299		uberon_slim|pheno_slim|efo_slim
HP:0006779	biolink:PhenotypicFeature	Alveolar rhabdomyosarcoma		UMLS:C0206655|MSH:D018232|SNOMEDCT_US:63449009|NCIT:C3749|SNOMEDCT_US:404053004	hp.json		http://purl.obolibrary.org/obo/HP_0006779		
HP:0006775	biolink:PhenotypicFeature	Multiple myeloma	A malignant plasma cell tumor growing within soft tissue or within the skeleton.	SNOMEDCT_US:415112005|MSH:D010954|MSH:D009101|SNOMEDCT_US:55921005|SNOMEDCT_US:109989006|SNOMEDCT_US:10639003|UMLS:C0026764|UMLS:C0032131	hp.json	Kahler's disease|Plasmocytoma	http://purl.obolibrary.org/obo/HP_0006775		
HP:0006778	biolink:PhenotypicFeature	Benign genitourinary tract neoplasm	A non-malignant neoplasm of the genitourinary system.	UMLS:C3804991	hp.json	Benign genitourinary tract tumour|Benign GU tract neoplasm|Benign genitourinary tract tumor	http://purl.obolibrary.org/obo/HP_0006778		
HP:0006771	biolink:PhenotypicFeature	Duodenal adenocarcinoma	A malignant epithelial tumor with a glandular organization that originates in the duodenum.	SNOMEDCT_US:408644002|UMLS:C0278804|UMLS:C0541912|MSH:D004379|NCIT:C2852|SNOMEDCT_US:254570009	hp.json	Duodenal cancer	http://purl.obolibrary.org/obo/HP_0006771		
HP:0006772	biolink:PhenotypicFeature	Renal angiomyolipoma	A benign renal neoplasm composed of fat, vascular, and smooth muscle elements.	NCIT:C3734|UMLS:C0241961|SNOMEDCT_US:254921004	hp.json	Angiomyolipoma|Kidney angiomyolipoma	http://purl.obolibrary.org/obo/HP_0006772		
HP:0006773	biolink:PhenotypicFeature	Cutaneous angiolipomas		NCIT:C3733|UMLS:C4024980	hp.json		http://purl.obolibrary.org/obo/HP_0006773		
HP:0006774	biolink:PhenotypicFeature	Ovarian papillary adenocarcinoma	The presence of a papillary adenocarcinoma of the ovary.	UMLS:C4024979|NCIT:C2853	hp.json		http://purl.obolibrary.org/obo/HP_0006774		
HP:0004112	biolink:PhenotypicFeature	Midline nasal groove	An abnormal groove on the midline of the nose that may extend to the nasal tip.	UMLS:C4025412	hp.json	Central nasal groove|Midline nasal groove	http://purl.obolibrary.org/obo/HP_0004112		
HP:0004110	biolink:PhenotypicFeature	obsolete Radially deviated index finger phalanges			hp.json		http://purl.obolibrary.org/obo/HP_0004110		
HP:0006770	biolink:PhenotypicFeature	Clear cell renal cell carcinoma	A subtype of renal cell carcinoma thought to originate from mature renal tubular cells in the proximal tubule of the nehpron.	SNOMEDCT_US:254915003|SNOMEDCT_US:188251003|SNOMEDCT_US:41607009|UMLS:C0279702|MSH:D002292	hp.json	Nonpapillary renal cell carcinoma	http://purl.obolibrary.org/obo/HP_0006770		
CHEBI:72813	biolink:ChemicalSubstance	exopolysaccharide	A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment.	Wikipedia:Extracellular_polymeric_substance|MetaCyc:Exopolysaccharides|PMID:11785425|PMID:18097339|PMID:20172021|PMID:19453747|PMID:17440912|PMID:20718297|PMID:15738217|PMID:2688547|PMID:1444258|PMID:16075348|PMID:6354590|PMID:20631870|Wikipedia:Exopolysaccharide|PMID:11160795	hp.json	exopolysaccharides|extracellular polymeric substance|extracellular polymeric substances	http://purl.obolibrary.org/obo/CHEBI_72813		3_STAR
HP:0006789	biolink:PhenotypicFeature	Mitochondrial encephalopathy		UMLS:C1852373|MSH:C538525	hp.json		http://purl.obolibrary.org/obo/HP_0006789		
HP:0006782	biolink:PhenotypicFeature	Malignant eosinophil proliferation		UMLS:C1851585|MSH:C565054	hp.json		http://purl.obolibrary.org/obo/HP_0006782		
HP:0006783	biolink:PhenotypicFeature	Posterior pharyngeal cleft		UMLS:C1848389	hp.json		http://purl.obolibrary.org/obo/HP_0006783		
HP:0006784	biolink:PhenotypicFeature	Paranasal sinus hypoplasia	Underdevelopment of the paranasal sinuses.	UMLS:C4280441|UMLS:C2749161|UMLS:C4280256|UMLS:C4280442	hp.json	Underdevelopment of paranasal sinus|Decreased volume of paranasal sinus|Decreased pneumatization of paranasal sinus|Hypotrophic paranasal sinus|Decreased size of paranasal sinus|Small paranasal sinus|Decreased growth of paranasal sinus|Atelectasis of paranasal sinus	http://purl.obolibrary.org/obo/HP_0006784		
HP:0006785	biolink:PhenotypicFeature	Limb-girdle muscular dystrophy	Muscular dystrophy affecting the muscles of the limb girdle (the hips and shoulders).	MSH:D049288|SNOMEDCT_US:93153005|UMLS:C0686353	hp.json	limb girdle muscular dystrophy	http://purl.obolibrary.org/obo/HP_0006785		
HP:0004122	biolink:PhenotypicFeature	Midline defect of the nose	This term groups together three conditions that presumably represent different degrees of severity of a midline defect of the nose or nasal tip.	UMLS:C4025411|UMLS:C4280539	hp.json	Midline cleft of nose|Midline nasal defect|Central defect of nose|Central cleft of nose|Central nasal defect|Midline defect of the nose	http://purl.obolibrary.org/obo/HP_0004122		
HP:0006780	biolink:PhenotypicFeature	Parathyroid carcinoma	A malignancy of the parathyroid glands. Parathyroid carcinoma usually secretes parathyroid hormone, leading to hyperparathyroidism.	UMLS:C0687150|SNOMEDCT_US:363481002|SNOMEDCT_US:255037004|MSH:D010282|NCIT:C2916	hp.json	Parathyroid Cancer	http://purl.obolibrary.org/obo/HP_0006780		
HP:0004121	biolink:PhenotypicFeature	obsolete Radially displaced proximal index finger phalanx			hp.json		http://purl.obolibrary.org/obo/HP_0004121		
HP:0006781	biolink:PhenotypicFeature	Hurthle cell thyroid adenoma	A kind of thyroid adenoma characterized by the presence of oxyphil cells.	UMLS:C1336750	hp.json		http://purl.obolibrary.org/obo/HP_0006781		
HP:0006758	biolink:PhenotypicFeature	Malignant genitourinary tract tumor	The presence of a malignant neoplasm of the genital system.	UMLS:C1834728	hp.json	Malignant GU tract tumor|Malignant genitourinary tract tumour|Malignant GU tract tumour	http://purl.obolibrary.org/obo/HP_0006758		
HP:0006753	biolink:PhenotypicFeature	Neoplasm of the stomach	A tumor (abnormal growth of tissue) of the stomach.	UMLS:C4020813|UMLS:C0038356|NCIT:C3262|SNOMEDCT_US:126824007|MSH:D013274	hp.json	Stomach tumour|Stomach tumor|Neoplasia of the stomach	http://purl.obolibrary.org/obo/HP_0006753		
HP:0006755	biolink:PhenotypicFeature	Cutaneous leiomyosarcoma	The presence of leiomyosarcoma of the skin.	UMLS:C0346067|SNOMEDCT_US:254771006|NCIT:C3158	hp.json		http://purl.obolibrary.org/obo/HP_0006755		
HP:0006756	biolink:PhenotypicFeature	Diffuse leiomyomatosis		UMLS:C4024984	hp.json		http://purl.obolibrary.org/obo/HP_0006756		
HP:0006751	biolink:PhenotypicFeature	Paraspinal neurofibromas		UMLS:C4024985	hp.json		http://purl.obolibrary.org/obo/HP_0006751		
HP:0006768	biolink:PhenotypicFeature	Localized neuroblastoma		UMLS:C4024981	hp.json	Localised neuroblastoma	http://purl.obolibrary.org/obo/HP_0006768		
HP:0006769	biolink:PhenotypicFeature	Myxoid subcutaneous tumors		UMLS:C1834421	hp.json	Myxoid subcutaneous tumours	http://purl.obolibrary.org/obo/HP_0006769		
HP:0006765	biolink:PhenotypicFeature	Chondrosarcoma	A slowly growing malignant neoplasm derived from cartilage cells.	UMLS:C0008479|MSH:D002813|SNOMEDCT_US:443520009|NCIT:C2946|SNOMEDCT_US:14990007	hp.json		http://purl.obolibrary.org/obo/HP_0006765		
HP:0006766	biolink:PhenotypicFeature	Papillary renal cell carcinoma	The presence of renal cell carcinoma in the renal papilla.	NCIT:C2916|MSH:D002292|UMLS:C1306837	hp.json		http://purl.obolibrary.org/obo/HP_0006766		
HP:0006767	biolink:PhenotypicFeature	Pituitary prolactin cell adenoma	A type of pituitary adenoma originating in prolactin secreting cells. This kind of adenoma is characterized by overproduction of prolactin, and may cause loss of menstrual periods and breast milk production in women.	SNOMEDCT_US:34337008|MSH:D015175|SNOMEDCT_US:134209002|UMLS:C0033375	hp.json	Pituitary prolactinoma|Prolactin-secreting pituitary adenoma	http://purl.obolibrary.org/obo/HP_0006767		
HP:0006762	biolink:PhenotypicFeature	Renal pelvic carcinoma	The presence of a carcinoma in the renal pelvis.	NCIT:C2916|UMLS:C4024983	hp.json		http://purl.obolibrary.org/obo/HP_0006762		
HP:0006763	biolink:PhenotypicFeature	Anal canal squamous carcinoma		UMLS:C4024982	hp.json		http://purl.obolibrary.org/obo/HP_0006763		
HP:0004100	biolink:PhenotypicFeature	Abnormal 2nd finger morphology	An anomaly of the second finger, also known as the index finger.	UMLS:C4021683	hp.json	Abnormality of the 2nd finger|Abnormality of index finger	http://purl.obolibrary.org/obo/HP_0004100		
UBERON:0016880	biolink:AnatomicalEntity	future nervous system	Primordium that develops into the nervous system.	AAO:0000477	hp.json	presumptive nervous system	http://purl.obolibrary.org/obo/UBERON_0016880		
UBERON:0002239	biolink:AnatomicalEntity	floating rib	A rib that is not connected to sternum or sternal cartilage.	MA:0001399|FMA:7595|OpenCyc:Mx4rvaPCWZwpEbGdrcN5Y29ycA|EMAPA:37494	hp.json	costa fluitante|costae fluitantes|vertebral rib|free rib|costae fluctuantes	http://purl.obolibrary.org/obo/UBERON_0002239		pheno_slim|uberon_slim
HP:0100088	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the 2nd toe		UMLS:C4022333	hp.json	Abnormality of the end part of the outermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100088		
HP:0100089	biolink:PhenotypicFeature	Abnormality of the epiphysis of the middle phalanx of the 2nd toe		UMLS:C4022332	hp.json	Abnormality of the end part of the middle bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100089		
HP:0100086	biolink:PhenotypicFeature	Stippling of the epiphyses of the 5th toe	The presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 5th toe.	UMLS:C4022335	hp.json	Speckled calcifications in the end part of the pinky toe bone|Speckled calcifications in the end part of the pinkie toe bone|Speckled calcifications in the end part of the little toe bone	http://purl.obolibrary.org/obo/HP_0100086		
UBERON:0016888	biolink:AnatomicalEntity	transitional anatomical structure	An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development.	AEO:0000132	hp.json		http://purl.obolibrary.org/obo/UBERON_0016888		
HP:0100087	biolink:PhenotypicFeature	Triangular epiphyses of the 5th toe		UMLS:C4022334	hp.json	Triangular end part of the pinky toe bone|Triangular end part of the pinkie toe bone|Triangular end part of the little toe bone	http://purl.obolibrary.org/obo/HP_0100087		
UBERON:0016887	biolink:AnatomicalEntity	entire extraembryonic component	The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism.	EHDAA2:0000003|EMAPA:16042|AEO:0000195	hp.json	extraembryonic component|extra-embryonic component	http://purl.obolibrary.org/obo/UBERON_0016887		
HP:0100084	biolink:PhenotypicFeature	Pseudoepiphyses of the 5th toe		UMLS:C4022337	hp.json		http://purl.obolibrary.org/obo/HP_0100084		
HP:0100085	biolink:PhenotypicFeature	Small epiphyses of the 5th toe		UMLS:C4022336	hp.json	Small end part of the pinky toe bone|Small end part of the pinkie toe bone|Small end part of the little toe bone	http://purl.obolibrary.org/obo/HP_0100085		
HP:0100082	biolink:PhenotypicFeature	Irregular epiphyses of the 5th toe		UMLS:C4022339	hp.json	Irregular end part of the little toe bone|Irregular end part of the pinky toe bone|Irregular end part of the pinkie toe bone	http://purl.obolibrary.org/obo/HP_0100082		
UBERON:0016884	biolink:AnatomicalEntity	shoulder joint	The joint that is formed by the union of the humerus, the scapula (or shoulder blade), and the clavicle (or collarbone). Commonly thought of as a single joint, the shoulder is actually made up of two separate joints - the glenohumeral and acromioclavicular joints.	MESH:D012785	hp.json	joint of shoulder region	http://purl.obolibrary.org/obo/UBERON_0016884		
HP:0100083	biolink:PhenotypicFeature	Ivory epiphyses of the 5th toe	Epiphyses of the 5th toe are hard and dense like ivory. Such an epiphysis has a uniformly dense appearance on radiographs.	UMLS:C4022338	hp.json	Increased bone density of end part of the pinkie toe bone|Increased bone density of end part of the little toe bone|Increased bone density of end part of the pinky toe bone	http://purl.obolibrary.org/obo/HP_0100083		
CHEBI:47880	biolink:ChemicalSubstance	steroid ester		KEGG:C15506	hp.json	steroid esters	http://purl.obolibrary.org/obo/CHEBI_47880		3_STAR
UBERON:0016886	biolink:AnatomicalEntity	muscle tissue of terminal part of digestive tract	Any muscle tissue of the distalmost portion of the digestive tract.		hp.json	rectum muscle structure|rectum muscle	http://purl.obolibrary.org/obo/UBERON_0016886		
HP:0100080	biolink:PhenotypicFeature	Enlarged epiphyses of the 5th toe		UMLS:C4022341	hp.json	Enlarged end part of the little toe bone|Enlarged end part of the pinky toe bone|Enlarged end part of the pinkie toe bone	http://purl.obolibrary.org/obo/HP_0100080		
UBERON:0016885	biolink:AnatomicalEntity	epithelium of terminal part of digestive tract	Epithelium lining the distalmost portion of the digestive tract.	WBbt:0005800|BTO:0005445	hp.json	rectum epithelium	http://purl.obolibrary.org/obo/UBERON_0016885		
HP:0100081	biolink:PhenotypicFeature	Fragmentation of the epiphyses of the 5th toe		UMLS:C4022340	hp.json	Fragmentation of the end part of the pinky toe bone|Fragmentation of the end part of the pinkie toe bone|Fragmentation of the end part of the little toe bone	http://purl.obolibrary.org/obo/HP_0100081		
CHEBI:47882	biolink:ChemicalSubstance	cyclic polypyrrole			hp.json	cyclic polypyrroles|macrocyclic polypyrroles|polypyrrole macrocycles	http://purl.obolibrary.org/obo/CHEBI_47882		3_STAR
HP:0100090	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the 2nd toe		UMLS:C4022331	hp.json	Abnormality of the end part of the innermost bone of the 2nd toe	http://purl.obolibrary.org/obo/HP_0100090		
CHEBI:33232	biolink:ChemicalSubstance	application	Intended use of the molecular entity or part thereof by humans.		hp.json		http://purl.obolibrary.org/obo/CHEBI_33232		3_STAR
UBERON:0002241	biolink:AnatomicalEntity	chondrocranium	Endoskeletal elements that encase the brain, nose, inner ear[cjm]. that part of the neurocranium formed by endochondral ossification and comprising the bones of the base of the skull[TFD].	AAO:0010169|EMAPA:17681|EHDAA2:0000243|VHOG:0000288|ZFA:0001424|TAO:0001424|Wikipedia:Chondrocranium	hp.json	neurocranium|calvarium	http://purl.obolibrary.org/obo/UBERON_0002241		vertebrate_core
CHEBI:33233	biolink:ChemicalSubstance	fundamental particle	A particle not known to have substructure.		hp.json	elementary particle|elementary particles	http://purl.obolibrary.org/obo/CHEBI_33233		3_STAR
UBERON:0002240	biolink:AnatomicalEntity	spinal cord	Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).	DMBA:17651|XAO:0000020|ZFA:0000075|SCTID:180959008|EHDAA2:0001255|NCIT:C12464|DHBA:12890|BM:SpC|VHOG:0000601|TAO:0000075|BTO:0001279|CALOHA:TS-0953|UMLS:C0037925|EFO:0000110|UMLS:C0037925|AAO:0010151|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=22|BAMS:SP|MAT:0000183|BAMS:Spinal|FMA:7647|MA:0000216|EMAPA:17577|MIAA:0000183|EV:0100316|Wikipedia:Spinal_cord|BIRNLEX:1709|GAID:695|EHDAA:2863|OpenCyc:Mx4rvVjjk5wpEbGdrcN5Y29ycA|MESH:D013116	hp.json	fissura cerebro-cerebellaris|spinal cord structure|cerebrocerebellar fissure|medulla spinalis|medulla spinalis|fissura cerebrocerebellaris|cerebro-cerebellar fissure|SpC|medulla spinalis|spinal medulla	http://purl.obolibrary.org/obo/UBERON_0002240		pheno_slim|efo_slim|cumbo|uberon_slim|vertebrate_core|major_organ|organ_slim
CHEBI:33234	biolink:ChemicalSubstance	vitamin E	Any member of a group of fat-soluble chromanols  that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.	PMID:7901680|PMID:34277234|PMID:7898412|PMID:33684201|PMID:33896432|MetaCyc:Vitamin-E|PMID:34278890|Wikipedia:Vitamin_E|PMID:33847203	hp.json	vitamin-E|vitamins E|vitamin E vitamers|vitamin E vitamer|vitamin E	http://purl.obolibrary.org/obo/CHEBI_33234		3_STAR
CHEBI:33238	biolink:ChemicalSubstance	monoatomic entity	A monoatomic entity is a molecular entity consisting of a single atom.		hp.json	atomic entity|monoatomic entities	http://purl.obolibrary.org/obo/CHEBI_33238		3_STAR
CHEBI:59869	biolink:ChemicalSubstance	L-alpha-amino acid zwitterion	Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group.		hp.json	L-alpha-amino acid zwitterions|an L-alpha-amino acid	http://purl.obolibrary.org/obo/CHEBI_59869		3_STAR
UBERON:0002242	biolink:AnatomicalEntity	nucleus pulposus	The jelly-like substance in the middle of the spinal disc which is a remnant of the notochord.	BTO:0003626|MESH:D000070614|EMAPA:18008|FMA:13550|MA:0000112|FMA:76703	hp.json	nucleus pulposus (diskus intervertebralis)|nucleus pulposus of intervertebral disk|pulpy nucleus|nucleus propulsus|nucleus propulsus of intervertebral disk	http://purl.obolibrary.org/obo/UBERON_0002242		pheno_slim|uberon_slim
UBERON:0002245	biolink:AnatomicalEntity	cerebellar hemisphere	A paired regions of the cerebellum that lie outside and lateral to the central vermis[MP]. The cerebellum consists of three parts, a median and two lateral, which are continuous with each other, and are substantially the same in structure. The median portion is constricted, and is called the vermis, from its annulated appearance which it owes to the transverse ridges and furrows upon it; the lateral expanded portions are named the hemispheres. The lateral hemisphere is considered the portion of the cerebellum to develop most recently. [WP,unvetted].	MA:0000200|BAMS:CH|MBA:1073|EMAPA:35218|DHBA:10659|NCIT:C32726|UMLS:C0228465|HBA:12930|DMBA:16920|BIRNLEX:1575|FMA:76925	hp.json	cerebellar hemisphere|cerebellar hemispheres|hemispherium cerebelli|cerebellum hemisphere|hemispherium cerebelli [H II - H X]|hemispherium cerebelli [hII-hX]|hemisphere of cerebellum|hemisphere of cerebellum [H II - H X]	http://purl.obolibrary.org/obo/UBERON_0002245		pheno_slim|uberon_slim
UBERON:0002244	biolink:AnatomicalEntity	premaxilla	One of the bones of the upper jaw situated between and in front of the maxillae[VHOG].	VHOG:0000426|EHDAA:6962|MA:0001493|AAO:0000461|ZFA:0000567|EHDAA:8033|FMA:77231|TAO:0000567|EMAPA:17641|FMA:76869	hp.json	premaxillary|incisive bone|premaxillary bone|os incisivum|premaxillae|premaxilla bone	http://purl.obolibrary.org/obo/UBERON_0002244		pheno_slim|uberon_slim|vertebrate_core
UBERON:0002228	biolink:AnatomicalEntity	rib	An intersegmental rod-shaped bone that forms in the peritoneal membrane and attach to the vertebral parapophyses.	MA:0000315|EFO:0003066|OpenCyc:Mx4rvVjNoZwpEbGdrcN5Y29ycA|UMLS:C0035561|VHOG:0001154|GAID:245|galen:Rib|FMA:7574|AAO:0000545|EMAPA:18010|NCIT:C12782|CALOHA:TS-2209|ZFA:0000538|MESH:D012272|TAO:0000538	hp.json	dorsal rib|pleural rib|ribs	http://purl.obolibrary.org/obo/UBERON_0002228		uberon_slim|vertebrate_core|pheno_slim|efo_slim
HP:0100099	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the 5th toe		UMLS:C4022322	hp.json	Abnormality of the end part of the innermost bone of the little toe|Abnormality of the end part of the innermost bone of the pinkie toe|Abnormality of the end part of the innermost bone of the pinky toe	http://purl.obolibrary.org/obo/HP_0100099		
HP:0100097	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the 5th toe		UMLS:C4022324	hp.json	Abnormality of the end part of the outermost bone of the pinky toe|Abnormality of the end part of the outermost bone of the little toe|Abnormality of the end part of the outermost bone of the pinkie toe	http://purl.obolibrary.org/obo/HP_0100097		
HP:0100098	biolink:PhenotypicFeature	Abnormality of the epiphysis of the middle phalanx of the 5th toe		UMLS:C4022323	hp.json	Abnormality of the end part of the middle bone of the pinkie toe|Abnormality of the end part of the middle bone of the pinky toe|Abnormality of the end part of the middle bone of the little toe	http://purl.obolibrary.org/obo/HP_0100098		
HP:0100095	biolink:PhenotypicFeature	Abnormality of the epiphysis of the middle phalanx of the 4th toe		UMLS:C4022326	hp.json	Abnormality of the end part of the middle bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100095		
UBERON:0016879	biolink:AnatomicalEntity	future central nervous system	Primordium that develops into the central nervous system.		hp.json	presumptive central nervous system|future CNS	http://purl.obolibrary.org/obo/UBERON_0016879		
HP:0100096	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the 4th toe		UMLS:C4022325	hp.json	Abnormality of the end part of the innermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100096		
HP:0100093	biolink:PhenotypicFeature	Abnormality of the epiphysis of the proximal phalanx of the 3rd toe		UMLS:C4022328	hp.json	Abnormality of the end part of the innermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100093		
HP:0100094	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the 4th toe		UMLS:C4022327	hp.json	Abnormality of the end part of the outermost bone of the 4th toe	http://purl.obolibrary.org/obo/HP_0100094		
CHEBI:45212	biolink:ChemicalSubstance	diphosphate(2-)	A divalent inorganic anion obtained by removal of both protons from diphosphoric acid.	PDBeChem:POP|DrugBank:DB02212|Gmelin:185085	hp.json	H2P2O7(2-)|PYROPHOSPHATE 2-|dihydrogen diphosphate	http://purl.obolibrary.org/obo/CHEBI_45212		3_STAR
HP:0100091	biolink:PhenotypicFeature	Abnormality of the epiphysis of the distal phalanx of the 3rd toe		UMLS:C4022330	hp.json	Abnormality of the end part of the outermost bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100091		
HP:0100092	biolink:PhenotypicFeature	Abnormality of the epiphysis of the middle phalanx of the 3rd toe		UMLS:C4022329	hp.json	Abnormality of the end part of the middle bone of the 3rd toe	http://purl.obolibrary.org/obo/HP_0100092		
CHEBI:33242	biolink:ChemicalSubstance	inorganic hydride			hp.json	inorganic hydrides	http://purl.obolibrary.org/obo/CHEBI_33242		3_STAR
CHEBI:33245	biolink:ChemicalSubstance	organic fundamental parent	An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system.		hp.json	organic parent hydrides|organic fundamental parents	http://purl.obolibrary.org/obo/CHEBI_33245		3_STAR
CHEBI:33246	biolink:ChemicalSubstance	inorganic group	Any substituent group which does not contain carbon.		hp.json	inorganic groups	http://purl.obolibrary.org/obo/CHEBI_33246		3_STAR
CHEBI:33247	biolink:ChemicalSubstance	organic group	Any substituent group or skeleton containing carbon.		hp.json	organic groups	http://purl.obolibrary.org/obo/CHEBI_33247		3_STAR
CHEBI:33248	biolink:ChemicalSubstance	hydrocarbyl group	A univalent group formed by removing a hydrogen atom from a hydrocarbon.		hp.json	grupo hidrocarbilo|hydrocarbyl group|grupos hidrocarbilo|hydrocarbyl groups|groupe hydrocarbyle	http://purl.obolibrary.org/obo/CHEBI_33248		3_STAR
CHEBI:33249	biolink:ChemicalSubstance	organyl group	Any organic substituent group, regardless of functional type, having one free valence at a carbon atom.		hp.json	groupe organyle|organyl group|grupo organilo|grupos organilo|organyl groups	http://purl.obolibrary.org/obo/CHEBI_33249		3_STAR
UBERON:0002236	biolink:AnatomicalEntity	costal cartilage	The nonvascular, resilient, flexible hyaline connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the with the lower border of the costal cartilage above it.	OpenCyc:Mx4rwP1g3pwpEbGdrcN5Y29ycA|EMAPA:35262|BTO:0001721|MESH:D066186|FMA:7591|NCIT:C32391|UMLS:C0222787|MA:0000106	hp.json	sternal cartilage|cartilagines costales|cartilago costalis	http://purl.obolibrary.org/obo/UBERON_0002236		pheno_slim|uberon_slim
UBERON:0002235	biolink:AnatomicalEntity	tubercle of rib	The tubercle of a rib is an eminence on the posterior surface, at the junction of the neck and body of the rib, and nearer the lower than the upper border. It consists of an articular and a non-articular portion. The articular portion, the lower and more medial of the two, presents a small, oval surface for articulation with the end of the transverse process of the lower of the two vertebrae to which the head is connected. The non-articular portion is a rough elevation, and affords attachment to the ligament of the tubercle. The tubercle is much more prominent in the upper than in the lower ribs[WP].	EMAPA:37736|FMA:7583|NCIT:C52729|MA:0001417|UMLS:C0222809	hp.json	tuberculum costae|rib tubercle	http://purl.obolibrary.org/obo/UBERON_0002235		pheno_slim|uberon_slim
UBERON:0002238	biolink:AnatomicalEntity	false rib	A rib that is not directly ventrally connected to the sternum.	OpenCyc:Mx4rwLzzTZwpEbGdrcN5Y29ycA|MA:0001398|FMA:7594|EMAPA:37493	hp.json	costa spuria|costae spuriae|asternal ribs	http://purl.obolibrary.org/obo/UBERON_0002238		uberon_slim
UBERON:0002237	biolink:AnatomicalEntity	true rib	A rib that is ventrally connected to the sternum.	OpenCyc:Mx4rv4-iWJwpEbGdrcN5Y29ycA|FMA:7592|EMAPA:37774|MA:0001419	hp.json	costa vera|costae verae	http://purl.obolibrary.org/obo/UBERON_0002237		
UBERON:0004895	biolink:AnatomicalEntity	alveolar smooth muscle	Alveolar smooth muscle is a type of non-striated muscle, found within the walls of the alveolus.	MA:0002759|EMAPA:35122	hp.json		http://purl.obolibrary.org/obo/UBERON_0004895		
UBERON:0002231	biolink:AnatomicalEntity	body of rib		UMLS:C0448161|NCIT:C52728|MA:0001416|EMAPA:36014|FMA:7577	hp.json	shaft of rib|rib body|rib shaft|corpus costae	http://purl.obolibrary.org/obo/UBERON_0002231		
UBERON:0002234	biolink:AnatomicalEntity	proximal phalanx of manus	A proximal phalanx that is part of a finger [Automatically generated definition].	EMAPA:37307|UMLS:C0730117|MA:0001395|NCIT:C52786|FMA:75816	hp.json	proximal phalanx of manual digit|phalanx proximalis manus|hand proximal phalanx|proximal phalanx of hand|proximal phalanx of finger|proximal phalanx of fore digit|proximal manual phalanx	http://purl.obolibrary.org/obo/UBERON_0002234		pheno_slim
CHEBI:33240	biolink:ChemicalSubstance	coordination entity	An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands).		hp.json	coordination entity|coordination entities|coordination compounds	http://purl.obolibrary.org/obo/CHEBI_33240		3_STAR
UBERON:0004893	biolink:AnatomicalEntity	interalveolar septum	A the thin septum that separates adjacent pulmonary alveoli, containing connective tissue constituents of the respiratory tissue and the capillary network of the blood supply of the lung.	BTO:0003149|NCIT:C49473|EMAPA:35433|UMLS:C1706784|MA:0000421	hp.json	septum interalveolare|alveolar septum	http://purl.obolibrary.org/obo/UBERON_0004893		pheno_slim
UBERON:0004894	biolink:AnatomicalEntity	alveolar wall	A wall that contains the alveoli.	UMLS:C0225695|BTO:0002543|FMA:14117|NCIT:C13085|MA:0002568|EMAPA:35120	hp.json	alveolus wall|pulmonary interalveolar septum|wall of pulmonary alveolus|pulmonary alveolar wall	http://purl.obolibrary.org/obo/UBERON_0004894		pheno_slim
CHEBI:33241	biolink:ChemicalSubstance	oxoacid derivative			hp.json	oxoacid derivatives	http://purl.obolibrary.org/obo/CHEBI_33241		3_STAR
UBERON:0002217	biolink:AnatomicalEntity	synovial joint	Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA].	TAO:0005153|CALOHA:TS-2138|EHDAA2:0003183|FMA:7501|MA:0000322|OpenCyc:Mx4rv2bBV5wpEbGdrcN5Y29ycA|AEO:0000183|NCIT:C32461|galen:SynovialJoint|SCTID:113234001|ZFA:0005153|Wikipedia:Synovial_joint	hp.json	diarthrodial joints|diarthrosis joint|diarthroses|articulatio synoviale|diarthrosis	http://purl.obolibrary.org/obo/UBERON_0002217		uberon_slim|vertebrate_core|pheno_slim
CHEBI:23899	biolink:ChemicalSubstance	icosanoid	Any member of the group of signalling molecules arising from oxidation of the three C20 essential fatty acids (EFAs) icosapentaenoic acid (EPA), arachidonic acid (AA) and dihomo-gamma-linolenic acid (DGLA).	PMID:12697726|PMID:19160658|LIPID_MAPS_class:LMFA03|PMID:2657063|Wikipedia:Eicosanoid|PMID:16107763	hp.json	eicosanoid|eicosanoids|icosanoids|icosanoid	http://purl.obolibrary.org/obo/CHEBI_23899		3_STAR
CHEBI:47867	biolink:ChemicalSubstance	indicator	Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc.		hp.json	Indikator	http://purl.obolibrary.org/obo/CHEBI_47867		3_STAR
CHEBI:47868	biolink:ChemicalSubstance	photosensitizing agent	A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.		hp.json	photosensitising agent	http://purl.obolibrary.org/obo/CHEBI_47868		3_STAR
UBERON:0004880	biolink:AnatomicalEntity	chordamesoderm	The central region of trunk mesoderm. This tissue forms the notochord.	AAO:0000478|EFO:0003426|ZFA:0000091|TAO:0000091	hp.json	presumptive notochord|chorda mesoderm|axial chorda mesoderm|dorsal mesoderm|dorsal mesoderm	http://purl.obolibrary.org/obo/UBERON_0004880		pheno_slim|efo_slim
CHEBI:35871	biolink:ChemicalSubstance	oxo monocarboxylic acid	Any monocarboxylic acid having at least one additional oxo functional group.		hp.json	oxo monocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_35871		3_STAR
CHEBI:35875	biolink:ChemicalSubstance	imidazopyrimidine			hp.json	imidazopyrimidines	http://purl.obolibrary.org/obo/CHEBI_35875		3_STAR
UBERON:0002224	biolink:AnatomicalEntity	thoracic cavity	The part of the coelemic cavity lumen that is enclosed by the walls of the thorax.	EMAPA:36497|GAID:93|Wikipedia:Thoracic_cavity|SCTID:243949006|FMA:7565|OpenCyc:Mx4rmvyleLfEEduAAAACs6hRXg|OpenCyc:Mx4rvhU_TpwpEbGdrcN5Y29ycA|MESH:D035423|MA:0000032|NCIT:C12905|UMLS:C0230139	hp.json	thoracic lumen|cavitas thoracis|cavity of thorax|cavitas thoracis|space of thoracic compartment|chest cavity|pectoral cavity|cavity of chest	http://purl.obolibrary.org/obo/UBERON_0002224		pheno_slim|uberon_slim
CHEBI:59845	biolink:ChemicalSubstance	3-hydroxy fatty acid	Any fatty acid with a hydroxy functional group in the beta- or 3-position. beta-Hydroxy fatty acids accumulate during cardiac hypoxia, and can also be used as chemical markers of bacterial endotoxins.	PMID:3094448|PMID:7406063|PMID:1226425|PMID:17392575	hp.json	3-OH fatty acid|3-hydroxy fatty acids|beta-hydroxy fatty acid|beta-OH fatty acids|beta-OH fatty acid|beta-hydroxy fatty acids|3-OH fatty acids	http://purl.obolibrary.org/obo/CHEBI_59845		3_STAR
UBERON:0002221	biolink:AnatomicalEntity	fontanelle	Anatomical structure that is a membranous gap between bones of the skull[TAO]. In humans: Fontanelles are soft spots on a baby's head which, during birth, enable the bony plates of the skull to flex, allowing the child's head to pass through the birth canal. The ossification of the bones of the skull cause the fontanelles to close over by a child's second birthday. The closures eventually form the sutures of the neurocranium. Although there are the two anterior and posterior fontanelles, there are two more fontanelles of interest, the mastoid fontanelle, and the sphenoidal fontanelle[WP].	ZFA:0005536|UMLS:C0224548|NCIT:C32621|MA:0001465|FMA:75438|TAO:0001738	hp.json	fontanelles|fontanels|fontanel|fonticuli cranii	http://purl.obolibrary.org/obo/UBERON_0002221		vertebrate_core|pheno_slim|uberon_slim
UBERON:0004883	biolink:AnatomicalEntity	lung mesenchyme	The mass of tissue made up of mesenchymal cells in the lung.	EMAPA:32866	hp.json	lung-associated mesenchyme|mesenchyme of lung|pulmonary mesenchyme	http://purl.obolibrary.org/obo/UBERON_0004883		pheno_slim
CHEBI:21241	biolink:ChemicalSubstance				hp.json		http://purl.obolibrary.org/obo/CHEBI_21241		
UBERON:0002207	biolink:AnatomicalEntity	xiphoid process	A cartilaginous extension to the distal part of the sternum.	EMAPA:18725|UMLS:C0043356|FMA:7488|MA:0001334|NCIT:C33895	hp.json	xiphoid process|processus xiphoideus|metasternum|processus xiphoideus|xiphoideus|xiphoid|xyphoid|xiphoid process|xiphoid process of sternum|xiphosternal junction|xiphisternum	http://purl.obolibrary.org/obo/UBERON_0002207		uberon_slim|pheno_slim
UBERON:0002209	biolink:AnatomicalEntity	fibrous joint	Nonsynovial joint in which the articulating bones or cartilages are connected by ligaments. Examples: sagittal suture, inferior tibiofibular syndesmosis, gomphosis.[FMA].	TAO:0005156|AEO:0000178|Wikipedia:Fibrous_joint|EMAPA:35344|SCTID:37772004|MA:0000321|ZFA:0005156|EHDAA2:0003178|FMA:7492	hp.json	articulatio fibrosa|junctura fibrosa|junctura fibrosa	http://purl.obolibrary.org/obo/UBERON_0002209		uberon_slim|vertebrate_core
CHEBI:47857	biolink:ChemicalSubstance	ureas			hp.json	urea derivatives	http://purl.obolibrary.org/obo/CHEBI_47857		3_STAR
UBERON:0002208	biolink:AnatomicalEntity	sternebra	One of the bony segments of the sternum[TFD].	EMAPA:18724|FMA:7489|MA:0001333	hp.json	sternebral bone	http://purl.obolibrary.org/obo/UBERON_0002208		uberon_slim|pheno_slim
UBERON:0004869	biolink:AnatomicalEntity	parietal organ	A part of the epithalamus present in some animal species. The eye may be photoreceptive and is usually associated with the pineal gland, regulating circadian rhythmicity and hormone production for thermoregulation. The parietal eye is a part of the epithalamus, which can be divided into two major parts; the epiphysis (the pineal organ, or pineal gland if mostly endocrine) and the parietal organ (often called the parietal eye, or third eye if it is photoreceptive). It arises as an anterior evagination of the pineal organ or as a separate outgrowth of the roof of the diencephalon. In some species, it protrudes through the skull.[4] The parietal eye uses a different biochemical method of detecting light than rod cells or cone cells in a normal vertebrate eye[WP].		hp.json	third eye|parietal eye	http://purl.obolibrary.org/obo/UBERON_0004869		
UBERON:0016855	biolink:AnatomicalEntity	ventral part of optic cup	The ventral region of the optic cup that gives rise to the ventral part of the retina.		hp.json	ventral region of optic cup|ventral optic cup	http://purl.obolibrary.org/obo/UBERON_0016855		
RO:0004047	biolink:NamedThing	causally upstream of or within, positive effect			hp.json		http://purl.obolibrary.org/obo/RO_0004047		
CHEBI:33229	biolink:ChemicalSubstance	vitamin (role)	A biochemical role played by any micronutrient that is an organic compound. Vitamins are present in foods in small amounts and are essential to normal metabolism and biochemical functions, usually as coenzymes. The term "vitamines" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines.	Wikipedia:Vitamin	hp.json	vitamin|vitamins|vitamines|vitamina|vitaminum|vitaminas|vitamine	http://purl.obolibrary.org/obo/CHEBI_33229		3_STAR
RO:0004046	biolink:NamedThing	causally upstream of or within, negative effect			hp.json		http://purl.obolibrary.org/obo/RO_0004046		
UBERON:0016854	biolink:AnatomicalEntity	dorsal part of optic cup	The dorsal region of the optic cup that gives rise to the dorsal part of the retina.		hp.json	dorsal region of optic cup|dorsal optic cup	http://purl.obolibrary.org/obo/UBERON_0016854		
CHEBI:33224	biolink:ChemicalSubstance	chromane	A benzopyran consisting of a pyran ring having a benzene ring ortho-fused across positions 2 and 3.	CAS:493-08-3|Beilstein:116150|Reaxys:116150|Gmelin:122981|CAS:493-08-3	hp.json	Chroman|3,4-dihydro-2H-1-benzopyran|3,4-dihydrobenzo[b]pyran|3,4-dihydro-2H-chromene|chromane	http://purl.obolibrary.org/obo/CHEBI_33224		3_STAR
CHEBI:59836	biolink:ChemicalSubstance	oxo fatty acid anion	A fatty acid anion carrying one or more oxo substituents		hp.json	oxo fatty acid anions|oxo-FA anion|oxo-FA anions	http://purl.obolibrary.org/obo/CHEBI_59836		3_STAR
UBERON:0002213	biolink:AnatomicalEntity	cartilaginous joint	Nonsynovial joint in which the articulating bones or cartilages are connected by cartilage. Examples: Spheno-occipital synchondrosis, first sternocostal joint, pubic symphysis.[FMA].	SCTID:58442004|MA:0000320|EMAPA:36581|FMA:7496|Wikipedia:Cartilaginous_joint|ZFA:0005155|TAO:0005155	hp.json	articulatio cartilaginea|junctura cartilaginea|junctura cartilaginea	http://purl.obolibrary.org/obo/UBERON_0002213		uberon_slim|vertebrate_core
UBERON:0026246	biolink:AnatomicalEntity	sacral spinal cord white matter		BIRNLEX:1500	hp.json	sacral spinal cord white matter|sacral spinal cord white matter	http://purl.obolibrary.org/obo/UBERON_0026246		
CHEBI:59835	biolink:ChemicalSubstance	hydroxy fatty acid anion	The conjugate base of any hydroxy fatty acid, formed by deprotonation of the carboxylic acid moiety.		hp.json	OH-fatty acid anion|OH-FA anion|hydroxy fatty acid anions|OH-FA-anions|OH-fatty acid anions	http://purl.obolibrary.org/obo/CHEBI_59835		3_STAR
UBERON:0002216	biolink:AnatomicalEntity	symphysis	Cartilaginous joint in which the articulating bones or cartilages are connected by fibrocartilage. Examples: pubic symphysis, intervertebral symphysis, manubriosternal joint.[FMA].	MA:0001504|Wikipedia:Symphysis|EMAPA:37758|FMA:7498|SCTID:1584001	hp.json	secondary cartilaginous joint	http://purl.obolibrary.org/obo/UBERON_0002216		uberon_slim
UBERON:0004875	biolink:AnatomicalEntity	nephrogenic cord	A portion of the urogenital ridge which is the source of much of the urinary system[WP].	NCIT:C34219|FMA:72168|UMLS:C1283944	hp.json	chorda nephrogenica	http://purl.obolibrary.org/obo/UBERON_0004875		
UBERON:0002215	biolink:AnatomicalEntity	synchondrosis	Cartilaginous joint in which the articulating bones or cartilages are connected by hyaline cartilage. Examples: spheno-occipital synchondrosis, first sternocostal joint.[FMA].	MA:0001501|FMA:7497|EMAPA:35846	hp.json	epiphysial cartilage|primary cartilaginous joint|cartilago epiphysialis	http://purl.obolibrary.org/obo/UBERON_0002215		uberon_slim|pheno_slim
UBERON:0004876	biolink:AnatomicalEntity	urogenital fold	One of of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora[MP].	FMA:321919|EMAPA:30888|EHDAA2:0004022	hp.json	urogenital ridge|urogenital fold|urethral fold	http://purl.obolibrary.org/obo/UBERON_0004876		pheno_slim
UBERON:0004873	biolink:AnatomicalEntity	splanchnopleure	A structure created during embryogenesis when the lateral mesoderm splits into two layers - the inner (or splanchnic) layer adheres to the endoderm, and with it forms the splanchnopleure[WP].	UMLS:C1519472|Wikipedia:Splanchnopleure|NCIT:C34303|VHOG:0000558|FMA:295564|EMAPA:16181|EHDAA:383|EHDAA2:0001903	hp.json	ventral splanchnic mesoderm|ventral splanchnic mesoderm	http://purl.obolibrary.org/obo/UBERON_0004873		
UBERON:0002210	biolink:AnatomicalEntity	syndesmosis	Fibrous joint in which the articulating bones or cartilages of the vertebral column and the limbs as well as articulating ossicles, are connected by skeletal ligaments or membranes. Examples: Intervertebral syndesmosis, inferior tibiofibular joint.[FMA].	MA:0001500|FMA:7494|EMAPA:37465	hp.json		http://purl.obolibrary.org/obo/UBERON_0002210		uberon_slim
UBERON:0004874	biolink:AnatomicalEntity	somatopleure	A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP].	Wikipedia:Somatopleure|NCIT:C34301|VHOG:0000557|FMA:295566|EMAPA:16180|UMLS:C1519423|EHDAA:381|EHDAA2:0001847	hp.json		http://purl.obolibrary.org/obo/UBERON_0004874		
CHEBI:35881	biolink:ChemicalSubstance	pnictogen hydride			hp.json	pnictogen hydride|pnictogen hydrides	http://purl.obolibrary.org/obo/CHEBI_35881		3_STAR
UBERON:0004871	biolink:AnatomicalEntity	somatic layer of lateral plate mesoderm	Layer of lateral plate mesoderm that forms the future body wall - underlies the ectoderm[WP].	Wikipedia:Lateral_plate_mesoderm#Division_into_layers|XAO:0000271|AAO:0011100|BILA:0000047|FMA:295570	hp.json	parietal mesoderm|somatic mesoderm|outer layer of lateral plate mesoderm	http://purl.obolibrary.org/obo/UBERON_0004871		pheno_slim
UBERON:0004872	biolink:AnatomicalEntity	splanchnic layer of lateral plate mesoderm	Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP].	Wikipedia:Lateral_plate_mesoderm#Division_into_layers|XAO:0000276|FMA:295568|AAO:0011102|BILA:0000044	hp.json	visceral mesoderm|splanchnic mesoderm|visceral mesoderm|inner layer of lateral plate mesoderm	http://purl.obolibrary.org/obo/UBERON_0004872		pheno_slim
CHEBI:59826	biolink:ChemicalSubstance	progestin	A synthetic progestogen.	Wikipedia:Progestin	hp.json	progestins	http://purl.obolibrary.org/obo/CHEBI_59826		3_STAR
RO:0004035	biolink:NamedThing	acts upstream of, negative effect	c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative		hp.json		http://purl.obolibrary.org/obo/RO_0004035		http://purl.obolibrary.org/obo/valid_for_go_gp2term
RO:0004032	biolink:NamedThing	acts upstream of or within, positive effect			hp.json		http://purl.obolibrary.org/obo/RO_0004032		http://purl.obolibrary.org/obo/valid_for_go_gp2term
RO:0004031	biolink:NamedThing	enables subfunction	Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P.		hp.json		http://purl.obolibrary.org/obo/RO_0004031		
RO:0004034	biolink:NamedThing	acts upstream of, positive effect	c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive		hp.json		http://purl.obolibrary.org/obo/RO_0004034		http://purl.obolibrary.org/obo/valid_for_go_gp2term
RO:0004033	biolink:NamedThing	acts upstream of or within, negative effect			hp.json		http://purl.obolibrary.org/obo/RO_0004033		http://purl.obolibrary.org/obo/valid_for_go_gp2term
UBERON:0002285	biolink:AnatomicalEntity	telencephalic ventricle	A brain ventricle that is part of a telencephalon. In mammals and species with an evaginated telencephalon, this is one of a pair of lateral structures, one in each hemisphere.	MA:0000192|DMBA:126651562|UMLS:C0152279|GAID:611|MESH:D020547|EV:0100307|BAMS:Tel-V|NCIT:C12834|BAMS:LV|ZFA:0000696|OpenCyc:Mx4rvYsFdZwpEbGdrcN5Y29ycA|BTO:0000879|EHDAA:3502|DHBA:10596|BIRNLEX:1263|CALOHA:TS-1230|BM:Tel-LV|TAO:0000696|EHDAA2:0001984|UMLS:C0152279|FMA:78448|EMAPA:16914|MBA:81|EHDAA:6576|EFO:0001961|HBA:9419|VHOG:0000643	hp.json	telencephalon lateral ventricle|forebrain ventricle|lateral ventricle of brain|telencephalic ventricle|lateral ventricles|lateral ventricle|telencephalic ventricles|telencephalic vesicle|tectal ventricle	http://purl.obolibrary.org/obo/UBERON_0002285		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas|efo_slim
UBERON:0002286	biolink:AnatomicalEntity	third ventricle	Part of the ventricular system of the brain, forming a single large cavity in the midline of the diencephalon; it is continuous with the lateral ventricles through the interventricular foramen and the fourth ventricle through the cerebral aqueduct. (Maryann Martone).	MA:0000182|GAID:614|TAO:0000161|EMAPA:16900|NCIT:C12827|EHDAA2:0000084|DHBA:10602|BAMS:V3|FMA:78454|EV:0100308|OpenCyc:Mx4rvakhcJwpEbGdrcN5Y29ycA|BM:Die-3V|UMLS:C0149555|CALOHA:TS-2058|UMLS:C0149555|MESH:D020542|BIRNLEX:714|HBA:9420|MBA:129|BAMS:3V|ZFA:0000161|VHOG:0000007	hp.json	ventriculus tertius cerebri|3rd ventricle|ventriculus diencephali|diencephalic vesicle|diencephalic ventricle	http://purl.obolibrary.org/obo/UBERON_0002286		uberon_slim|vertebrate_core|pheno_slim
UBERON:0002289	biolink:AnatomicalEntity	midbrain cerebral aqueduct	Part of ventricular system of brain consisting of a narrow channel in the midbrain connecting the third and fourth ventricles. (Maryann Martone).	BAMS:AQ|BAMS:Aq|MA:0000208|EHDAA2:0001163|UMLS:C0007769|FMA:78467|EV:0100309|UMLS:C0007769|ZFA:0000159|MBA:140|DHBA:12369|HBA:265505702|EMAPA:17795|ncithesaurus:Cerebral_Aqueduct|TAO:0000159|DHBA:10651|MESH:D002535|GAID:583|NCIT:C32135|BIRNLEX:1261|EHDAA:3696|BM:MB-AQ|DMBA:126651722|EFO:0003501|VHOG:0000832	hp.json	Sylvian aqueduct|mesencephalic vesicle|cerebral aqueduct proper|medial tectal ventricle|mesencephalic ventricle|aqueduct of Sylvius|aqueductus mesencephali|aqueductus mesencephali|cerebral aquaduct|midbrain ventricle|cerebral aqueduct|tectal ventricle|midbrain cerebral aqueduct|aqueduct (Sylvius)|cerebral aqueduct of Sylvius|aqueduct of Sylvius|aqueduct|mesencephalic duct|aqueduct of midbrain	http://purl.obolibrary.org/obo/UBERON_0002289		human_reference_atlas|efo_slim|uberon_slim|vertebrate_core|pheno_slim
UBERON:0002288	biolink:AnatomicalEntity	choroid plexus of third ventricle	Part of choroid plexus contained in the third ventricle.	BAMS:cp3v|NLX:18606|MA:0000879|NCIT:C49782|UMLS:C0152291|VHOG:0001374|FMA:78462|ZFA:0001444|EMAPA:18543|BAMS:chp3|TAO:0001444|HBA:9709	hp.json	choroid plexus third ventricle|chorioid plexus of cerebral hemisphere of third ventricle|third ventricle choroid plexus|third ventricle chorioid plexus of cerebral hemisphere|diencephalic choroid plexus|3rd ventricle choroid plexus|chorioid plexus of third ventricle	http://purl.obolibrary.org/obo/UBERON_0002288		vertebrate_core
CHEBI:23888	biolink:ChemicalSubstance	drug	Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.		hp.json	medicine|drugs	http://purl.obolibrary.org/obo/CHEBI_23888		3_STAR
CHEBI:35868	biolink:ChemicalSubstance	hydroxy monocarboxylic acid	Any monocarboxylic acid which also contains a separate (alcoholic or phenolic) hydroxy substituent.		hp.json	hydroxy acid|hydroxy monocarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_35868		3_STAR
HP:0006706	biolink:PhenotypicFeature	Cystic liver disease		MSH:C536330|SNOMEDCT_US:72925005|UMLS:C0158683	hp.json		http://purl.obolibrary.org/obo/HP_0006706		
HP:0006707	biolink:PhenotypicFeature	Abnormality of the hepatic vasculature	An abnormality of the hepatic vasculature.	UMLS:C4024994	hp.json	Abnormality of the liver vasculature|Abnormality of liver blood vessels	http://purl.obolibrary.org/obo/HP_0006707		
HP:0006709	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the nipples		UMLS:C3150086	hp.json	Absent/underdeveloped nipples|Nipples absent or rudimentary|Absent/rudimentary nipples|Absent/small nipples	http://purl.obolibrary.org/obo/HP_0006709		
HP:0006702	biolink:PhenotypicFeature	Coronary artery dissection	Acute occurrence of a dissection (tear within the tunica intima and entry of blood into the tunica media) of a coronary artery.	MSH:C565153|UMLS:C1852540	hp.json		http://purl.obolibrary.org/obo/HP_0006702		
HP:0006703	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the lungs		UMLS:C4024996	hp.json	Absent/small lungs|Absent/underdeveloped lungs	http://purl.obolibrary.org/obo/HP_0006703		
HP:0006704	biolink:PhenotypicFeature	Abnormal coronary artery morphology	Any structural abnormality of the coronary arteries.	Fyler:3100|SNOMEDCT_US:28574005|UMLS:C0158623	hp.json		http://purl.obolibrary.org/obo/HP_0006704		
HP:0006705	biolink:PhenotypicFeature	Abnormal atrioventricular valve morphology	An abnormality of an atrioventricular valve.	UMLS:C4024995	hp.json	Abnormality of the atrioventricular valves	http://purl.obolibrary.org/obo/HP_0006705		
UBERON:0002270	biolink:AnatomicalEntity	hyaloid artery	An artery that is part of the optic stalk of the eye and extends from the optic disc through the vitreous humor to the lens.	VHOG:0001478|TAO:0005045|FMA:77670|EHDAA2:0004072|XAO:0004155|EMAPA:19242|ZFA:0005045	hp.json	arteria hyaloidea|central artery of retina|hyaloid arteries|Cloquets canal|Cloquet's canal	http://purl.obolibrary.org/obo/UBERON_0002270		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas
CHEBI:59814	biolink:ChemicalSubstance	L-alpha-amino acid anion	Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group.		hp.json	L-alpha-amino carboxylate	http://purl.obolibrary.org/obo/CHEBI_59814		3_STAR
UBERON:0002279	biolink:AnatomicalEntity	vestibular aqueduct	At the hinder part of the medial wall of the vestibule is the orifice of the vestibular aqueduct, which extends to the posterior surface of the petrous portion of the temporal bone. It transmits a small vein, and contains a tubular prolongation of the membranous labyrinth, the ductus endolymphaticus, which ends in a cul-de-sac between the layers of the dura mater within the cranial cavity. [WP,unvetted].	MA:0001186|FMA:77821|GAID:885|MESH:D014723	hp.json	aqueductus vestibuli	http://purl.obolibrary.org/obo/UBERON_0002279		pheno_slim|uberon_slim
UBERON:0002275	biolink:AnatomicalEntity	reticular formation	A composite substructure of the brainstem that consists of the midbrain reticular formation, the pontine reticular formation and the medullary reticular formation ( Carpenter-1983 ).	MESH:D012154|MA:0003185|Wikipedia:Reticular_formation|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1223|FMA:77719|EMAPA:35188|BAMS:RET|NLX:143558|SCTID:361552007	hp.json	reticular formation of the brainstem|brainstem reticular formation|brainstem reticular formation|reticular formation (classical)|brain stem reticular formation	http://purl.obolibrary.org/obo/UBERON_0002275		uberon_slim
UBERON:0002263	biolink:AnatomicalEntity	lentiform nucleus	The lentiform nucleus or lenticular nucleus comprises the putamen and the globus pallidus within the basal ganglia. It is a large, cone-shaped mass of gray matter just lateral to the internal capsule. [WP,unvetted].	EV:0100186|EMAPA:18208|UMLS:C0162342|NCIT:C32977|MA:0000896|BTO:0002250|EMAPA:19147|FMA:77615|OpenCyc:Mx4rvvyH2ZwpEbGdrcN5Y29ycA	hp.json	lenticular nucleus|nucleus lentiformis|nucleus lentiformis|nucleus lenticularis	http://purl.obolibrary.org/obo/UBERON_0002263		uberon_slim
RO:0004007	biolink:NamedThing	has primary input or output	p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c.	RO:0004007	hp.json		http://purl.obolibrary.org/obo/RO_0004007		http://purl.obolibrary.org/obo/valid_for_go_ontology
RO:0004009	biolink:NamedThing	has primary input	p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.	RO:0004009	hp.json		http://purl.obolibrary.org/obo/RO_0004009		http://purl.obolibrary.org/obo/valid_for_go_ontology
RO:0004008	biolink:NamedThing	has primary output	p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.	RO:0004008	hp.json		http://purl.obolibrary.org/obo/RO_0004008		http://purl.obolibrary.org/obo/valid_for_go_ontology
UBERON:0002268	biolink:AnatomicalEntity	olfactory organ	An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ.	BTO:0001772|VHOG:0000287|AAO:0010180|FBbt:00005158|XAO:0000273|FMA:77659	hp.json	olfactory neuroepithelium|organum olfactorium|primary olfactory organ|olfactory sensory organ|organ olfactus|main olfactory organ|olfactory sense organ|olfactory organ	http://purl.obolibrary.org/obo/UBERON_0002268		functional_classification
UBERON:0002265	biolink:AnatomicalEntity	olfactory tract	White matter tract that contains projections from the olfactory bulb to other parts of the brain.	EMAPA:35615|DHBA:12074|BAMS:olf|DHBA:12073|UMLS:C0162435|MA:0000975|BIRNLEX:1663|NCIT:C33207|HBA:9302|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=283|FMA:77626|BTO:0003647	hp.json	pedunclulus olfactorius|olfactory stalk|tractus olfactorius|tractus olfactorium|tractus olfactorius|olfactory peduncle	http://purl.obolibrary.org/obo/UBERON_0002265		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0002264	biolink:AnatomicalEntity	olfactory bulb	A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO].	BAMS:OB|FMA:77624|CALOHA:TS-0702|BTO:0000961|AAO:0010165|MA:0000194|NCIT:C28401|BAMS:DLB|BAMS:Olf|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=279|BM:Tel-OB|DHBA:10307|EV:0100173|MESH:D009830|EMAPA:32809|BIRNLEX:1137|ZFA:0000402|GAID:633|XAO:0004180|HBA:9303|VHOG:0000033|UMLS:C0028936|EHDAA2:0004705|TAO:0000402|UMLS:C0028936	hp.json	olfactory lobe (Barr & Kiernan)|bulbus olfactorius (Morgagni)|olfactory lobe|bulbus olfactorius|bulbus olfactorius	http://purl.obolibrary.org/obo/UBERON_0002264		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
UBERON:0016896	biolink:AnatomicalEntity	periosteum of long bone	A periosteum that is part of a long bone.	FMA:32677	hp.json	long bone periosteum	http://purl.obolibrary.org/obo/UBERON_0016896		
UBERON:0002250	biolink:AnatomicalEntity	popliteal artery	The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.	MA:0002021|GAID:504|UMLS:C0032649|MESH:D011150|FMA:77155|NCIT:C33337|EMAPA:37109|OpenCyc:Mx4rvduV6pwpEbGdrcN5Y29ycA	hp.json	arteria poplitea	http://purl.obolibrary.org/obo/UBERON_0002250		human_reference_atlas|uberon_slim
UBERON:0002258	biolink:AnatomicalEntity	dorsal funiculus of spinal cord	The white substance of the spinal cord lying on either side between the posterior median sulcus and the dorsal root.	ZFA:0000501|FMA:77461|TAO:0000501	hp.json	posterior white column of spinal cord|posterior funiculus|posterior funiculus of spinal cord|dorsal funiculus|dorsal white column of spinal cord|funiculus dorsalis|dorsal funiculus of spinal cord|funiculus posterior medullae spinalis	http://purl.obolibrary.org/obo/UBERON_0002258		uberon_slim|vertebrate_core
UBERON:0002257	biolink:AnatomicalEntity	ventral horn of spinal cord	The ventral grey column of the spinal cord[MP]. The neurons of the ventral region of the mature spinal cord participate in motor output[GO].	BTO:0005151|MA:0001134|BAMS:VH|SCTID:279443000|UMLS:C0228569|BIRNLEX:2668|ZFA:0000702|NCIT:C33859|UMLS:C0228590|TAO:0000702|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1751|VHOG:0001288|EMAPA:35794|Wikipedia:Anterior_horn_of_spinal_cord|FMA:256541|EMAPA:18575	hp.json	ventral region of spinal cord|anterior column|ventral horn spinal cord|ventral grey horn|spinal cord ventral horn|anterior column|spinal cord anterior horn|anterior horn|anterior grey column of spinal cord|ventral grey column of spinal cord|ventral spinal cord|cornu anterius medullae spinalis|cornu anterius medullae spinalis|anterior horn (spinal cord)|anterior column of the spinal cord|anterior horn (spinal cord)|anterior column of the spinal cord|ventral gray matter of spinal cord|columna grisea anterior medullae spinalis|ventral horns spinal cord|ventral horn of the spinal cord|anterior gray horn of spinal cord|anterior gray column of spinal cord|ventral gray column of spinal cord	http://purl.obolibrary.org/obo/UBERON_0002257		pheno_slim|vertebrate_core
UBERON:0004938	biolink:AnatomicalEntity	submucosa of biliary tree	A submucosa that is part of a biliary tree [Automatically generated definition].	FMA:18009	hp.json	submucosa of biliary tract|biliary tree submucosa|biliary tract submucosa	http://purl.obolibrary.org/obo/UBERON_0004938		
UBERON:0004939	biolink:AnatomicalEntity	submucosa of common bile duct	A submucosa that is part of a common bile duct [Automatically generated definition].	FMA:18011	hp.json	submucosa of ductus choledochus (biliaris)|ductus choledochus (biliaris) submucosa|common bile ductal submucosa|common bile duct submucosa	http://purl.obolibrary.org/obo/UBERON_0004939		
UBERON:0004936	biolink:AnatomicalEntity	submucosa of pyloric antrum	A submucosa that is part of a pyloric antrum [Automatically generated definition].	FMA:17060	hp.json	antrum of stomach submucosa|submucosa of stomach pyloric antrum|pyloric antrum submucosa|submucosa of antrum of stomach|stomach pyloric antrum submucosa	http://purl.obolibrary.org/obo/UBERON_0004936		
UBERON:0004937	biolink:AnatomicalEntity	submucosa of pylorus	A submucosa that is part of a pylorus [Automatically generated definition].	FMA:17462|EMAPA:27201	hp.json	pylorus submucosa|pyloric part of stomach submucosa|submucosa of stomach pyloric region|pylorus submucosa|pyloric submucosa|submucosa of pyloric part of stomach|stomach pyloric region submucosa	http://purl.obolibrary.org/obo/UBERON_0004937		
UBERON:0004934	biolink:AnatomicalEntity	submucosa of body of stomach	A submucosa that is part of a body of stomach [Automatically generated definition].	FMA:17059	hp.json	corpus gastricum (ventriculare) submucosa|submucosa of gastric body|submucosa of stomach body|gastric body submucosa|submucosa of corpus gastricum (ventriculare)|body of stomach submucosa|stomach body submucosa	http://purl.obolibrary.org/obo/UBERON_0004934		
GO:0007113	biolink:BiologicalProcess	endomitotic cell cycle	A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.	Wikipedia:Mitosis#Endomitosis	hp.json	endomitosis	http://purl.obolibrary.org/obo/GO_0007113		
GO:0010769	biolink:BiologicalProcess	regulation of cell morphogenesis involved in differentiation	Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.		hp.json		http://purl.obolibrary.org/obo/GO_0010769		
UBERON:0016918	biolink:AnatomicalEntity	upper vermilion	A vermilion that is part of a upper lip.	FMA:59827	hp.json	vermilion border of upper lip|vermilion of upper lip	http://purl.obolibrary.org/obo/UBERON_0016918		
GO:0010760	biolink:BiologicalProcess	negative regulation of macrophage chemotaxis	Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0010760		
UBERON:0016919	biolink:AnatomicalEntity	lower vermilion	A vermilion that is part of a lower lip.	FMA:59828|SCTID:245800000	hp.json	vermilion border of lower lip|vermilion of lower lip	http://purl.obolibrary.org/obo/UBERON_0016919		
GO:0010763	biolink:BiologicalProcess	positive regulation of fibroblast migration	Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.		hp.json	positive regulation of fibroblast cell migration	http://purl.obolibrary.org/obo/GO_0010763		
UBERON:0016913	biolink:AnatomicalEntity	frenulum of lower lip	A frenulum of lip that is part of a lower lip.	FMA:59822	hp.json	lower lip frenulum|frenulum labii inferioris|f. labii inferioris|frenulum labii inferioris	http://purl.obolibrary.org/obo/UBERON_0016913		
GO:0010764	biolink:BiologicalProcess	negative regulation of fibroblast migration	Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.		hp.json	negative regulation of fibroblast cell migration	http://purl.obolibrary.org/obo/GO_0010764		
GO:0010761	biolink:BiologicalProcess	fibroblast migration	Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.		hp.json	fibroblast cell migration	http://purl.obolibrary.org/obo/GO_0010761		
UBERON:0016915	biolink:AnatomicalEntity	vermilion	The zone of the skin that surrounds a lip and is colored red due to thin epithelium and presence of eleidin.	SCTID:362086008|FMA:59824	hp.json	vermilion of lip|vermillion|vermilion border of lip|vermilion border	http://purl.obolibrary.org/obo/UBERON_0016915		
GO:0010762	biolink:BiologicalProcess	regulation of fibroblast migration	Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.		hp.json	regulation of fibroblast cell migration	http://purl.obolibrary.org/obo/GO_0010762		
UBERON:0004943	biolink:AnatomicalEntity	submucosa of urinary bladder	The submucous layer of the wall of the urinary bladder.	BTO:0002117|EMAPA:32275|FMA:15929	hp.json	submucosa of bladder|bladder submucosa|tela submucosa vesicae|submucous layer of urinary bladder|tela submucosa vesicae urinariae|urinary bladder submucosa|tela submucosa (vesica urinaria)	http://purl.obolibrary.org/obo/UBERON_0004943		human_reference_atlas
UBERON:0004941	biolink:AnatomicalEntity	submucosa of right hepatic duct	A submucosa that is part of a right hepatic duct [Automatically generated definition].	FMA:18015	hp.json	right hepatic duct submucosa|right hepatic ductal submucosa	http://purl.obolibrary.org/obo/UBERON_0004941		
UBERON:0004942	biolink:AnatomicalEntity	submucosa of left hepatic duct	A submucosa that is part of a left hepatic duct [Automatically generated definition].	FMA:18017	hp.json	left hepatic duct submucosa|left hepatic ductal submucosa	http://purl.obolibrary.org/obo/UBERON_0004942		
UBERON:0004940	biolink:AnatomicalEntity	submucosa of common hepatic duct	A submucosa that is part of a common hepatic duct [Automatically generated definition].	FMA:18014	hp.json	hepatic duct submucosa|submucosa of hepatic duct|common hepatic duct submucosa|common hepatic ductal submucosa	http://purl.obolibrary.org/obo/UBERON_0004940		
UBERON:0004925	biolink:AnatomicalEntity	submucosa of laryngopharynx	A submucosa that is part of a hypopharynx [Automatically generated definition].	FMA:55072	hp.json	submucosa of hypopharynx|tela submucosa (pars laryngea pharyngis)|hypopharynx submucosa|submucosa of laryngeal pharynx|laryngeal pharynx submucosa|laryngopharynx submucosa	http://purl.obolibrary.org/obo/UBERON_0004925		
UBERON:0004926	biolink:AnatomicalEntity	submucosa of cystic duct	A submucosa that is part of a cystic duct [Automatically generated definition].	FMA:18013	hp.json	cystic ductal submucosa|cystic duct submucosa	http://purl.obolibrary.org/obo/UBERON_0004926		
UBERON:0004923	biolink:AnatomicalEntity	organ component layer	A part of a wall of an organ that forms a layer.	FMA:82485	hp.json		http://purl.obolibrary.org/obo/UBERON_0004923		upper_level
UBERON:0004924	biolink:AnatomicalEntity	submucosa of pharynx	The tissue underlying the tunica mucosa of the pharynx.	SCTID:19594009|BTO:0002113|FMA:75144	hp.json	submucous coat of pharynx|pharynx submucosa|tela submucosa pharyngis|pharyngobasilar fascia|pharyngeal submucosa|submucous layer of pharynx|tela submucosa pharyngea	http://purl.obolibrary.org/obo/UBERON_0004924		
UBERON:0016910	biolink:AnatomicalEntity	frenulum of lip		FMA:59820	hp.json	labial frenulum|frenulum labii|lip frenulum|medial labial frenulum	http://purl.obolibrary.org/obo/UBERON_0016910		
UBERON:0016912	biolink:AnatomicalEntity	frenulum of upper lip	A frenulum of lip that is part of a upper lip.	FMA:59821	hp.json	upper lip frenulum|frenulum labii superioris|f. labii superioris	http://purl.obolibrary.org/obo/UBERON_0016912		
GO:0009790	biolink:BiologicalProcess	embryo development	The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.	Wikipedia:Embryogenesis	hp.json	embryogenesis|embryogenesis and morphogenesis|embryonal development	http://purl.obolibrary.org/obo/GO_0009790		gocheck_do_not_manually_annotate|goslim_plant|goslim_chembl
GO:0009791	biolink:BiologicalProcess	post-embryonic development	The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.		hp.json		http://purl.obolibrary.org/obo/GO_0009791		goslim_plant
GO:0010770	biolink:BiologicalProcess	positive regulation of cell morphogenesis involved in differentiation	Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.		hp.json		http://purl.obolibrary.org/obo/GO_0010770		
GO:0010771	biolink:BiologicalProcess	negative regulation of cell morphogenesis involved in differentiation	Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.		hp.json		http://purl.obolibrary.org/obo/GO_0010771		
GO:0009786	biolink:BiologicalProcess	regulation of asymmetric cell division	Any process that modulates the frequency, rate or extent of asymmetric cell division.		hp.json		http://purl.obolibrary.org/obo/GO_0009786		
UBERON:0004932	biolink:AnatomicalEntity	submucosa of sigmoid colon	A submucosa that is part of a sigmoid colon [Automatically generated definition].	FMA:15027	hp.json	sigmoid colon submucosa	http://purl.obolibrary.org/obo/UBERON_0004932		
UBERON:0004931	biolink:AnatomicalEntity	submucosa of descending colon	A submucosa that is part of a descending colon [Automatically generated definition].	FMA:15020	hp.json	descending colon submucosa	http://purl.obolibrary.org/obo/UBERON_0004931		
UBERON:0004919	biolink:AnatomicalEntity	external urethral sphincter		FMA:85274|EMAPA:37790|MA:0002401|NCIT:C52561|UMLS:C1710586	hp.json	urethralis|m. urethralis|urethralis muscle|external urethral sphincter muscle|external sphincter muscle of urethra|external sphincter of urethra|musculus sphincter urethrae membranaceae|annulus urethralis	http://purl.obolibrary.org/obo/UBERON_0004919		
UBERON:0004916	biolink:AnatomicalEntity	anal sphincter	A sphincter muscle that is part of a anal region.	EMAPA:36052	hp.json	sphincter analia|anal region sphincter	http://purl.obolibrary.org/obo/UBERON_0004916		
UBERON:0004917	biolink:AnatomicalEntity	urethral sphincter	A sphincter muscle surrounding the urethra.	EMAPA:37789|MA:0002650	hp.json	urethral sphincter muscle|sphincter muscle of urethra|sphincter urethrae|sphincter of urethra	http://purl.obolibrary.org/obo/UBERON_0004917		
UBERON:0004914	biolink:AnatomicalEntity	duodenal papilla	One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct.	MA:0003107|EMAPA:18662|NCIT:C119578|FMA:15953	hp.json	papilla duodenalis|papilla of duodenum|papilla duodeni	http://purl.obolibrary.org/obo/UBERON_0004914		
UBERON:0004915	biolink:AnatomicalEntity	sphincter of hepatopancreatic ampulla	Muscular valve that controls the flow of digestive juices (bile and pancreatic juice) through the ampulla of Vater into the second part of the duodenum. Relaxed by the hormone Cholecystokinin (CCK) via vasoactive intestinal polypeptide (VIP).[WP].	EMAPA:18663|FMA:15077|GAID:285|UMLS:C0028872|MESH:D009803|NCIT:C13065	hp.json	sphincter of Oddi|musculus sphincter ampullae|hepatopancreatic ampullary sphincter|sphincter of ampulla of vater|musculus sphincter ampullae hepatopancreatica|Oddi's sphincter	http://purl.obolibrary.org/obo/UBERON_0004915		human_reference_atlas
UBERON:0004912	biolink:AnatomicalEntity	biliary bud		VHOG:0001351|EMAPA:16561|EMAPA_RETIRED:16565|EHDAA2:0000171	hp.json	hepatic diverticulum	http://purl.obolibrary.org/obo/UBERON_0004912		
UBERON:0004913	biolink:AnatomicalEntity	hepatopancreatic ampulla	A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct.	galen:AmpullaOfVater|FMA:15076|GAID:283|ZFA:0005167|NCIT:C13011|TAO:0005167|CALOHA:TS-2348|MESH:D014670|UMLS:C0042425	hp.json	biliaropancreatic ampulla|ampulla of bile duct|papilla duodeni major|ampulla of Vater|ampulla biliaropancreatica|ampulla Vaterii|ampulla hepatopancreatica|papilla Vateri|Vater's ampulla	http://purl.obolibrary.org/obo/UBERON_0004913		vertebrate_core|human_reference_atlas
NBO:0000160	biolink:NamedThing	sleep duration			hp.json		http://purl.obolibrary.org/obo/NBO_0000160		
GO:0071709	biolink:BiologicalProcess	membrane assembly	The aggregation, arrangement and bonding together of a set of components to form a membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0071709		
GO:0071705	biolink:BiologicalProcess	nitrogen compound transport	The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0071705		
GO:0071704	biolink:BiologicalProcess	organic substance metabolic process	The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.		hp.json	organic molecular entity metabolism|organic substance metabolism|organic molecular entity metabolic process	http://purl.obolibrary.org/obo/GO_0071704		
GO:0071702	biolink:BiologicalProcess	organic substance transport	The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon.		hp.json		http://purl.obolibrary.org/obo/GO_0071702		
GO:0009755	biolink:BiologicalProcess	hormone-mediated signaling pathway	The series of molecular signals mediated by the detection of a hormone.		hp.json	hormone mediated signalling	http://purl.obolibrary.org/obo/GO_0009755		
UBERON:0004921	biolink:AnatomicalEntity	subdivision of digestive tract	A proximal-distal subdivision of the digestive tract.	FMA:71131|FBbt:00100315	hp.json	alimentary system subdivision|intestinal tract|subdivision of alimentary system|segment of intestinal tract	http://purl.obolibrary.org/obo/UBERON_0004921		non_informative
NBO:0000163	biolink:NamedThing	REM frequency			hp.json		http://purl.obolibrary.org/obo/NBO_0000163		
NBO:0000162	biolink:NamedThing	REM duration	"Duration of REM sleep." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000162		
UBERON:0004907	biolink:AnatomicalEntity	lower digestive tract	The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition].	UMLS:C0226875|galen:LowerGastrointestinalTract|FMA:49179|Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract|SCTID:279973004|NCIT:C33010	hp.json	lower gastrointestinal tract|gut|lower GI tract	http://purl.obolibrary.org/obo/UBERON_0004907		uberon_slim
UBERON:0004908	biolink:AnatomicalEntity	upper digestive tract	The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum.	NCIT:C33837|UMLS:C0226874|galen:UpperGastrointestinalTract|SCTID:181244000|FMA:49177|Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract	hp.json	upper GI tract|upper gastrointestinal tract	http://purl.obolibrary.org/obo/UBERON_0004908		uberon_slim
UBERON:0004905	biolink:AnatomicalEntity	articulation	Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts.	FBbt:00005811	hp.json	joint	http://purl.obolibrary.org/obo/UBERON_0004905		grouping_class
UBERON:0004906	biolink:AnatomicalEntity	ectodermal part of digestive tract	A portion of the gut that is derived from ectoderm.		hp.json	gut ectoderm|ectodermal gut	http://purl.obolibrary.org/obo/UBERON_0004906		
UBERON:0004904	biolink:AnatomicalEntity	neuron projection bundle connecting eye with brain	A neuron projection bundle that connects the retina or its analog in the eye with the brain. This includes the vertebrate optic nerve (not truly a nerve) as well as analogous structures such as the Bolwig nerve in Drosophila.	BTO:0000966|EV:0100351|FBbt:00001956|TADS:0000232	hp.json	optic nerve|optic nerve (generic)	http://purl.obolibrary.org/obo/UBERON_0004904		grouping_class|pheno_slim
UBERON:0004902	biolink:AnatomicalEntity	urogenital sinus epithelium	The fetal urogenital sinus (from which the prostate derives) is a simple cylinder of stratified basal epithelium, surrounded by mesenchyme and positioned between the embryonic bladder and pelvic urethra.	EMAPA:31509|EHDAA2:0004061	hp.json	epithelium of urogenital sinus|UGE	http://purl.obolibrary.org/obo/UBERON_0004902		
UBERON:0004909	biolink:AnatomicalEntity	epithelium of gonad	An epithelium surrounding a gonad.	EHDAA:4032|NCIT:C32676|EHDAA:5931|UMLS:C1517534	hp.json	gonadal epithelium|gonad epithelium|gonadal sheath	http://purl.obolibrary.org/obo/UBERON_0004909		
GO:0010758	biolink:BiologicalProcess	regulation of macrophage chemotaxis	Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0010758		
GO:0010759	biolink:BiologicalProcess	positive regulation of macrophage chemotaxis	Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0010759		
NBO:0000170	biolink:NamedThing	memory behavior	"Behavior related with the ability of an organism's ability to store, retain, and recall information and experiences." [NBO:GVG]		hp.json	memory behaviour	http://purl.obolibrary.org/obo/NBO_0000170		
UBERON:0004910	biolink:AnatomicalEntity	epithelium of male gonad	An epithelium surrounding a testis.	BTO:0001364|EMAPA:17973	hp.json	testis epithelium|testis sheath	http://purl.obolibrary.org/obo/UBERON_0004910		
UBERON:0004911	biolink:AnatomicalEntity	epithelium of female gonad	An epithelium surrounding an ovary.	BTO:0003661	hp.json	ovarian epithelium|ovary epithelium|ovarian sheath	http://purl.obolibrary.org/obo/UBERON_0004911		
CL:2000070	biolink:Cell	optic choroid fibroblast	Any fibroblast that is part of a optic choroid.		hp.json		http://purl.obolibrary.org/obo/CL_2000070		
CL:2000072	biolink:Cell	adipose microvascular endothelial cell	Any microvascular endothelial cell that is part of a adipose tissue.		hp.json		http://purl.obolibrary.org/obo/CL_2000072		
UBERON:0002317	biolink:AnatomicalEntity	white matter of cerebellum	Regional part of cerebellum consisting of the myelinated axons lying deep to the granule cell layer, excluding the deep cerebellar nuclei and the cerebellar peduncles.	DMBA:16926|UMLS:C0152381|BAMS:cbw|TAO:0002183|EMAPA:35235|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=691|BAMS:CB-white|BIRNLEX:1562|FMA:83943|HBA:9288|NCIT:C49217|ZFA:0001708|MA:0002430|UMLS:C0152381	hp.json	cerebellum white matter|cerebellar tracts/commissures|medullary substance of cerebellum|substantia centralis medullaris cerebelli|substantia medullaris cerebelli|cerebellar white matter	http://purl.obolibrary.org/obo/UBERON_0002317		pheno_slim|vertebrate_core
UBERON:0002316	biolink:AnatomicalEntity	white matter	Neural tissue consisting of myelinated axons connecting grey matter areas of the central nervous system.	TAO:0002143|FMA:83929|NLX:412|TAO:0002142|VHOG:0001764|HBA:9218|OpenCyc:Mx4rwOAsDZwpEbGdrcN5Y29ycA|PBA:294022044|AEO:0001011|NLXANAT:101177|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2870|UMLS:C0682708|MESH:D066127|EMAPA:35927|MA:0001135|ZFA:0001682|Wikipedia:White_matter|TAO:0000145|NCIT:C33892|AEO:0000139	hp.json	CNS white matter|CNS tract/commissure|white matter of neuraxis|substantia alba|white mater|substantia alba|neuronal white matter|white substance|CNS tracts and commissures	http://purl.obolibrary.org/obo/UBERON_0002316		uberon_slim|vertebrate_core
UBERON:0002319	biolink:AnatomicalEntity	mesangium	The inner layer of the glomerulus, within the basement membrane surrounding the glomerular capillaries.	MA:0002617|EMAPA:36561|BTO:0002494|EMAPA:28248|FMA:84139|UMLS:C0017655|NCIT:C33101	hp.json		http://purl.obolibrary.org/obo/UBERON_0002319		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0002318	biolink:AnatomicalEntity	white matter of spinal cord	The regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites.	SCTID:279436006|BAMS:SCwhite|MA:0000910|EMAPA:35795|FMA:83945|UMLS:C0458457|DHBA:146035088|NCIT:C33893	hp.json	spinal cord white matter|spinal cord white matter of neuraxis|white matter of neuraxis of spinal cord|white substance of spinal cord|substantia alba medullae spinalis|spinal cord white substance	http://purl.obolibrary.org/obo/UBERON_0002318		pheno_slim
GO:0010721	biolink:BiologicalProcess	negative regulation of cell development	Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0010721		
CL:2000074	biolink:Cell	splenocyte	Any leukocyte that is part of a spleen.		hp.json		http://purl.obolibrary.org/obo/CL_2000074		
CL:2000073	biolink:Cell	migratory cardiac neural crest cell	Any migratory neural crest cell that is part of a cardiac neural crest.		hp.json		http://purl.obolibrary.org/obo/CL_2000073		
UBERON:0004980	biolink:AnatomicalEntity	mucosa of ureter	A mucosa that is part of a ureter [Automatically generated definition].	FMA:15894|galen:MucousMembraneOfUreter	hp.json	ureteric mucosa|ureteral mucosa|mucosal layer of ureter|ureter mucosa of organ|ureter mucous membrane|ureter mucosa|mucosa of organ of ureter|ureter organ mucosa|tunica mucosa ureteris|mucous membrane of ureter|organ mucosa of ureter|tunica mucosa (ureter)	http://purl.obolibrary.org/obo/UBERON_0004980		
GO:0010720	biolink:BiologicalProcess	positive regulation of cell development	Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.		hp.json		http://purl.obolibrary.org/obo/GO_0010720		
GO:0044106	biolink:BiologicalProcess	cellular amine metabolic process	The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.		hp.json		http://purl.obolibrary.org/obo/GO_0044106		
UBERON:0004987	biolink:AnatomicalEntity	mucosa of laryngopharynx	A mucosa that is part of a hypopharynx [Automatically generated definition].	FMA:55030	hp.json	laryngopharynx mucosa|laryngopharynx mucous membrane|laryngopharynx organ mucosa|mucous membrane of hypopharynx|organ mucosa of hypopharynx|hypopharynx mucosa of organ|mucosa of hypopharynx|mucosa of organ of laryngopharynx|laryngeal pharynx mucosa|laryngeal pharynx organ mucosa|organ mucosa of laryngeal pharynx|mucous membrane of laryngeal pharynx|laryngeal pharynx mucosa of organ|mucosa of organ of hypopharynx|hypopharynx mucous membrane|mucosa of laryngeal pharynx|organ mucosa of laryngopharynx|mucous membrane of laryngopharynx|hypopharynx mucosa|hypopharynx organ mucosa|laryngeal pharynx mucous membrane|mucosa of organ of laryngeal pharynx|laryngopharynx mucosa of organ	http://purl.obolibrary.org/obo/UBERON_0004987		
UBERON:0002324	biolink:AnatomicalEntity	muscle of back	Any muscle organ that is part of a back [Automatically generated definition].	MA:0000496|FMA:85216|EMAPA:35161	hp.json	muscle organ of back|back muscle organ|back muscle	http://purl.obolibrary.org/obo/UBERON_0002324		
UBERON:0002323	biolink:AnatomicalEntity	coelemic cavity lumen	The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities.	SCTID:361348008|ZFA:0001438|FBbt:00005060|TAO:0001438|BTO:0001707|AEO:0000186|UMLS:C0333343|EHDAA2:0000267|FMA:85006|RETIRED_EHDAA2:0003186|NCIT:C25444|galen:BodyCavity	hp.json	celom|coelomic cavity|coelome|coelomic cavity lumen|hemocoel|main body cavity|coelom|space of body compartment|body cavity|ventral body cavity	http://purl.obolibrary.org/obo/UBERON_0002323		uberon_slim|vertebrate_core
UBERON:0004988	biolink:AnatomicalEntity	mucosa of cystic duct	A mucosa that is part of a cystic duct [Automatically generated definition].	FMA:14690	hp.json	mucosa of organ of cystic duct|cystic duct mucous membrane|cystic duct mucosa|cystic duct organ mucosa|cystic ductal mucosa|organ mucosa of cystic duct|cystic duct mucosa of organ|mucous membrane of cystic duct	http://purl.obolibrary.org/obo/UBERON_0004988		
UBERON:0004985	biolink:AnatomicalEntity	mucosa of ejaculatory duct	A mucosa that is part of a ejaculatory duct [Automatically generated definition].	FMA:19373	hp.json	ejaculatory duct mucosa of organ|ejaculatory duct mucous membrane|mucosa of organ of ejaculatory duct|mucous membrane of ejaculatory duct|organ mucosa of ejaculatory duct|ejaculatory duct mucosa|ejaculatory ductal mucosa|ejaculatory duct organ mucosa	http://purl.obolibrary.org/obo/UBERON_0004985		
UBERON:0002326	biolink:AnatomicalEntity	lamina propria of urethra	A lamina propria that is part of a urethra [Automatically generated definition].	FMA:85276|MA:0001689|EMAPA:37785	hp.json	lamina propria mucosae of urethra|urethral lamina propria|urethra lamina propria mucosae|urethra lamina propria mucosa|urethra lamina propria|lamina propria mucosa of urethra	http://purl.obolibrary.org/obo/UBERON_0002326		
UBERON:0004986	biolink:AnatomicalEntity	mucosa of deferent duct	A mucosa that is part of a vas deferens [Automatically generated definition].	FMA:19240	hp.json	vas deferen mucous membrane|mucosa of organ of vas deferen|sperm duct mucosa|vas deferens mucosa|sperm duct organ mucosa|vas deferens mucous membrane|vas deferens organ mucosa|sperm duct mucous membrane|deferent duct mucosa of organ|organ mucosa of deferent duct|mucous membrane of deferent duct|vas deferen mucosa|mucosa of organ of vas deferens|organ mucosa of ductus deferens|mucous membrane of ductus deferens|vas deferen organ mucosa|mucosa of organ of sperm duct|ductus deferens mucosa of organ|mucosa of ductus deferens|tunica mucosa (ductus deferens)|tunica mucosa ductus deferentis|mucosa of vas deferens|organ mucosa of vas deferens|deferent duct mucous membrane|ductus deferens mucosa|mucous membrane of vas deferens|mucosa of sperm duct|mucosa of organ of deferent duct|deferent duct mucosa|mucous membrane of vas deferen|organ mucosa of sperm duct|mucous membrane of sperm duct|mucosa of organ of ductus deferens|deferent ductal mucosa|ductus deferens organ mucosa|organ mucosa of vas deferen|vas deferen mucosa of organ|ductus deferens mucous membrane|mucosa of vas deferen|deferent duct organ mucosa|vas deferens mucosa of organ|sperm duct mucosa of organ	http://purl.obolibrary.org/obo/UBERON_0004986		
UBERON:0002325	biolink:AnatomicalEntity	epithelium of urethra	The urethra is a renal system organ that carries urine from the bladder to outside the body. The epithelium is the tubular, planar layer of cells through which the urine passes..	UMLS:C1710584|FMA:85275|EMAPA:31518|NCIT:C49309|MA:0001686	hp.json	urethra epithelial tissue|urethral plate|urethral epithelium|urethra epithelium|urethral seam|epithelial tissue of urethra	http://purl.obolibrary.org/obo/UBERON_0002325		
UBERON:0004983	biolink:AnatomicalEntity	mucosa of vagina	A mucosa that is part of a vagina [Automatically generated definition].	FMA:19975|BTO:0005676	hp.json	vagina mucosa|vagina organ mucosa|vagina mucous membrane|mucosa of organ of vagina|mucous membrane of vagina|organ mucosa of vagina|vaginal mucosa|vagina mucosa of organ|tunica mucosa vaginae	http://purl.obolibrary.org/obo/UBERON_0004983		
UBERON:0004984	biolink:AnatomicalEntity	mucosa of seminal vesicle	A mucosa that is part of a seminal vesicle [Automatically generated definition].	FMA:19405	hp.json	seminal gland mucosa of organ|mucosa of organ of seminal vesicle|organ mucosa of seminal gland|mucous membrane of seminal gland|seminal vesicle mucous membrane|mucosa of seminal gland|seminal vesicle mucosa|seminal vesicle organ mucosa|mucosa of organ of seminal gland|seminal gland mucous membrane|mucous membrane of seminal vesicle|tunica mucosa glandulae vesiculosae|seminal vesicle mucosa of organ|organ mucosa of seminal vesicle|seminal gland mucosa|seminal gland organ mucosa	http://purl.obolibrary.org/obo/UBERON_0004984		
UBERON:0004982	biolink:AnatomicalEntity	mucosa of epiglottis	A mucosa that is part of a epiglottis [Automatically generated definition].	FMA:64015	hp.json	mucous membrane of epiglottis|organ mucosa of epiglottis|epiglottis mucosa of organ|epiglottis mucosa|epiglottis organ mucosa|epiglottis mucous membrane|mucosa of organ of epiglottis	http://purl.obolibrary.org/obo/UBERON_0004982		
CL:2000061	biolink:Cell	placental amniotic mesenchymal stromal cell	Any mesenchymal stem cell that is part of a placenta.		hp.json		http://purl.obolibrary.org/obo/CL_2000061		
CL:2000060	biolink:Cell	placental villous trophoblast	A trophoblast of placental villi.  These cells fuse to form synctial  trophoplast - the placental side of the interface between the placenta and maternal blood sinusoids in the decidua.	BTO:0006208|BTO:0006119	hp.json	vCTB|villous cytotrophoblast	http://purl.obolibrary.org/obo/CL_2000060		
UBERON:0002305	biolink:AnatomicalEntity	layer of hippocampus	The layers of the laminar structure of the hippocampus.	BIRNLEX:1192|FMA:277842|MA:0002427|FMA:83679|EMAPA:35407	hp.json	hippocampus proper layer|cytoarchitectural fields of hippocampal formation|hippocampus layer|layer of cornu ammonis	http://purl.obolibrary.org/obo/UBERON_0002305		pheno_slim
UBERON:0002308	biolink:AnatomicalEntity	nucleus of brain	A neural nucleus that is part of the brain.	UMLS:C1706993|ZFA:0005575|FMA:83840|NCIT:C49346|MA:0000811|EMAPA:35185|SCTID:426465002	hp.json	brain nucleus|brain nuclei	http://purl.obolibrary.org/obo/UBERON_0002308		
UBERON:0002307	biolink:AnatomicalEntity	choroid plexus of lateral ventricle	Part of choroid plexus contained in the lateral ventricle.	HBA:9708|NCIT:C32309|EMAPA:17769|DHBA:10601|VHOG:0001376|ZFA:0001447|TAO:0001447|MA:0000961|BAMS:cplv|EHDAA2:0004449|FMA:83711|UMLS:C0152289|NLX:32548	hp.json	chorioid plexus of lateral ventricle|chorioid plexus of cerebral hemisphere of lateral ventricle|lateral ventricle choroid plexus|lateral ventricle chorioid plexus of cerebral hemisphere|choroid plexus telencephalic ventricle	http://purl.obolibrary.org/obo/UBERON_0002307		vertebrate_core
PR:000021468	biolink:Protein	sonic hedgehog protein proteolytic cleavage product	A sonic hedgehog protein that has been processed by proteolytic cleavage.		hp.json	SHH/ClvPrd	http://purl.obolibrary.org/obo/PR_000021468		
CL:2000067	biolink:Cell	cardiac atrium fibroblast	Any fibroblast that is part of a cardiac atrium.		hp.json		http://purl.obolibrary.org/obo/CL_2000067		
CL:2000066	biolink:Cell	cardiac ventricle fibroblast	Any fibroblast that is part of a cardiac ventricle.		hp.json		http://purl.obolibrary.org/obo/CL_2000066		
CL:2000068	biolink:Cell	pericardium fibroblast	Any fibroblast that is part of a pericardium.		hp.json		http://purl.obolibrary.org/obo/CL_2000068		
CL:2000063	biolink:Cell	ovarian fibroblast	Any fibroblast that is part of a female gonad.		hp.json		http://purl.obolibrary.org/obo/CL_2000063		
CL:2000062	biolink:Cell	placental villus capillary endothelial cell	Any capillary endothelial cell that is part of a placenta.		hp.json		http://purl.obolibrary.org/obo/CL_2000062		
CL:2000064	biolink:Cell	ovarian surface epithelial cell	Any epithelial cell that is part of a female gonad.		hp.json		http://purl.obolibrary.org/obo/CL_2000064		
GO:0009743	biolink:BiologicalProcess	response to carbohydrate	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.		hp.json	response to carbohydrate stimulus	http://purl.obolibrary.org/obo/GO_0009743		
GO:0071711	biolink:BiologicalProcess	basement membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the basement membrane.		hp.json	basement membrane organisation	http://purl.obolibrary.org/obo/GO_0071711		
UBERON:0002315	biolink:AnatomicalEntity	gray matter of spinal cord	The ridge-shaped grey matter of the spinal cord that extends longitudunally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue.	NLXANAT:100204|BAMS:Scgrey|DHBA:146035048|EMAPA:35792|UMLS:C0475853|MA:0000002|SCTID:279441003|NCIT:C32696|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2619|FMA:256580	hp.json	grey matter of spinal cord|spinal cord grey matter|spinal cord gray matter|spinal cord grey substance|gray substance of spinal cord|substantia grisea medullae spinalis|gray matter of spinal cord|grey substance of spinal cord	http://purl.obolibrary.org/obo/UBERON_0002315		pheno_slim
PR:O14841	biolink:Protein	5-oxoprolinase (human)	A 5-oxoprolinase that is encoded in the genome of human.	Reactome:R-HSA-1247948|UniProtKB:O14841	hp.json	5-OPase (human)|OPLAH|hOPLAH|5-oxo-L-prolinase (human)|pyroglutamase (human)	http://purl.obolibrary.org/obo/PR_O14841		
CL:2000091	biolink:Cell	endometrial microvascular endothelial cells	Any microvascular endothelial cell that is part of a endometrial blood vessel.		hp.json		http://purl.obolibrary.org/obo/CL_2000091		
CHEBI:47788	biolink:ChemicalSubstance	3-oxo steroid	Any oxo steroid where an oxo substituent is located at position 3.	PMID:9811880|KEGG:C01876|MetaCyc:3-Oxosteroids	hp.json	3-Oxosteroid|3-oxosteroids|a 3-oxosteroid|3-oxo steroids	http://purl.obolibrary.org/obo/CHEBI_47788		3_STAR
GO:0010701	biolink:BiologicalProcess	positive regulation of norepinephrine secretion	Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.		hp.json		http://purl.obolibrary.org/obo/GO_0010701		
UBERON:0016943	biolink:AnatomicalEntity	lower premolar tooth			hp.json	mandibular premolar tooth|lower premolar tooth|LP	http://purl.obolibrary.org/obo/UBERON_0016943		
UBERON:0016944	biolink:AnatomicalEntity	upper premolar tooth			hp.json	UP|upper premolar tooth|maxillary premolar tooth	http://purl.obolibrary.org/obo/UBERON_0016944		
GO:0010700	biolink:BiologicalProcess	negative regulation of norepinephrine secretion	Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.		hp.json		http://purl.obolibrary.org/obo/GO_0010700		
GO:0046785	biolink:BiologicalProcess	microtubule polymerization	The addition of tubulin heterodimers to one or both ends of a microtubule.		hp.json	microtubule assembly|microtubule formation	http://purl.obolibrary.org/obo/GO_0046785		
NCBITaxon:142796	biolink:OrganismalEntity	Eumycetozoa		PMID:11062127|PMID:9342353|GC_ID:1	hp.json	mycetozoans|Mycetozoa|Eumycetozoa Zopf, 1884	http://purl.obolibrary.org/obo/NCBITaxon_142796		
GO:0071746	biolink:CellularComponent	IgA immunoglobulin complex, circulating	A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json	IgA antibody|IgA1 antibody|IgA2 antibody	http://purl.obolibrary.org/obo/GO_0071746		
GO:0009712	biolink:BiologicalProcess	catechol-containing compound metabolic process	The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent.		hp.json	catechol metabolic process|catechol metabolism	http://purl.obolibrary.org/obo/GO_0009712		
UBERON:0002302	biolink:AnatomicalEntity	myocardium of atrium	The atrial part of middle layer of the heart, comprised of involuntary muscle.	TAO:0001374|FMA:83509|MA:0000081|EFO:0003087|EMAPA:32746|ZFA:0001374|SCTID:191910002|VHOG:0000602	hp.json	atrial myocardium|atrium myocardium|atrium cardiac muscle	http://purl.obolibrary.org/obo/UBERON_0002302		efo_slim|vertebrate_core|pheno_slim
GO:0071745	biolink:CellularComponent	IgA immunoglobulin complex	A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json	IgA1 antibody|IgA2 antibody	http://purl.obolibrary.org/obo/GO_0071745		
UBERON:0002301	biolink:AnatomicalEntity	layer of neocortex	One of the layers of the neocortex. These layers are defined by distinctive populations of cells based on somata size, shape, or density, that are aligned into sheets.	ABA:CTX1-6b|EMAPA:35588|FMA:83138|MA:0000186	hp.json	layer of neocortex|cerebral cortex layer|neocortex layer|lamina of neocortex|cortical layer	http://purl.obolibrary.org/obo/UBERON_0002301		
GO:0009713	biolink:BiologicalProcess	catechol-containing compound biosynthetic process	The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.		hp.json	catechol formation|catechol biosynthesis|catechol biosynthetic process|catechol anabolism|catechol synthesis	http://purl.obolibrary.org/obo/GO_0009713		
GO:0071743	biolink:CellularComponent	IgE immunoglobulin complex, circulating	A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json	IgE antibody	http://purl.obolibrary.org/obo/GO_0071743		
UBERON:0002304	biolink:AnatomicalEntity	layer of dentate gyrus	One of the three layers of the dentate gyrus of the hippocampal formation.	MA:0002429|EMAPA:35278|FMA:83678	hp.json	dentate gyrus layer|dentate gyrus cell layer	http://purl.obolibrary.org/obo/UBERON_0002304		
GO:0071742	biolink:CellularComponent	IgE immunoglobulin complex	A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json		http://purl.obolibrary.org/obo/GO_0071742		
GO:0009719	biolink:BiologicalProcess	response to endogenous stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.		hp.json		http://purl.obolibrary.org/obo/GO_0009719		gocheck_do_not_manually_annotate|goslim_plant
CHEBI:47773	biolink:ChemicalSubstance	very-low-density lipoprotein cholesterol	Cholesterol esters and free cholesterol which are contained in or bound to very low density lipoproteins (VLDL).		hp.json	VLDL-C|pre-beta-lipoprotein cholesterol|VLDL cholesterol	http://purl.obolibrary.org/obo/CHEBI_47773		3_STAR
CL:2000081	biolink:Cell	melanocyte of skin of face	Any melanocyte of skin that is part of a skin of face.		hp.json		http://purl.obolibrary.org/obo/CL_2000081		
CHEBI:47774	biolink:ChemicalSubstance	low-density lipoprotein cholesterol	Cholesterol esters and free cholesterol which are contained in or bound to low-density lipoproteins (LDL).		hp.json	beta-lipoprotein cholesterol|LDL cholesterol|LDL-C	http://purl.obolibrary.org/obo/CHEBI_47774		3_STAR
CL:2000080	biolink:Cell	mesenchymal stem cell of abdominal adipose tissue	Any mesenchymal stem cell of adipose tissue that is part of an abdomen.		hp.json	mesenchymal stem cell of abdominal adipose	http://purl.obolibrary.org/obo/CL_2000080		
CHEBI:47775	biolink:ChemicalSubstance	high-density lipoprotein cholesterol	Cholesterol esters and free cholesterol which are contained in or bound to high-density lipoproteins (HDL).		hp.json	HDL-C|alpha-lipoprotein cholesterol|HDL cholesterol	http://purl.obolibrary.org/obo/CHEBI_47775		3_STAR
GO:0010718	biolink:BiologicalProcess	positive regulation of epithelial to mesenchymal transition	Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.		hp.json		http://purl.obolibrary.org/obo/GO_0010718		
GO:0010719	biolink:BiologicalProcess	negative regulation of epithelial to mesenchymal transition	Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.		hp.json		http://purl.obolibrary.org/obo/GO_0010719		
CHEBI:47778	biolink:ChemicalSubstance	glyceride	Any ester resulting from the condensation of one or more of the hydroxy groups of glycerol (propane-1,2,3-triol) with fatty acids.		hp.json	glycerides|glycerides|acylglycerols|glyceride	http://purl.obolibrary.org/obo/CHEBI_47778		3_STAR
UBERON:0004945	biolink:AnatomicalEntity	submucosa of neck of urinary bladder	A submucosa that is part of a neck of urinary bladder [Automatically generated definition].	EMAPA:32276|FMA:17851	hp.json	vesical neck submucosa|urinary bladder neck submucosa|submucosa of bladder neck|neck of urinary bladder submucosa|submucosa of neck of bladder|submucosa of vesical neck|submucosa of urinary bladder neck|neck of bladder submucosa|bladder neck submucosa	http://purl.obolibrary.org/obo/UBERON_0004945		
UBERON:0004946	biolink:AnatomicalEntity	submucosa of ileum	A submucosa that is part of a ileum [Automatically generated definition].	FMA:14957	hp.json	ileal submucosa|ileum submucosa	http://purl.obolibrary.org/obo/UBERON_0004946		human_reference_atlas
GO:0010712	biolink:BiologicalProcess	regulation of collagen metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.		hp.json	regulation of collagen metabolism	http://purl.obolibrary.org/obo/GO_0010712		
GO:0010713	biolink:BiologicalProcess	negative regulation of collagen metabolic process	Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.		hp.json		http://purl.obolibrary.org/obo/GO_0010713		
GO:0010716	biolink:BiologicalProcess	negative regulation of extracellular matrix disassembly	Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.		hp.json	down regulation of extracellular matrix disassembly|inhibition of extracellular matrix disassembly|negative regulation of extracellular matrix degradation|down-regulation of extracellular matrix disassembly|negative regulation of extracellular matrix breakdown|downregulation of extracellular matrix disassembly	http://purl.obolibrary.org/obo/GO_0010716		
GO:0010717	biolink:BiologicalProcess	regulation of epithelial to mesenchymal transition	Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.		hp.json		http://purl.obolibrary.org/obo/GO_0010717		
GO:0010714	biolink:BiologicalProcess	positive regulation of collagen metabolic process	Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.		hp.json	positive regulation of collagen metabolism	http://purl.obolibrary.org/obo/GO_0010714		
GO:0010715	biolink:BiologicalProcess	regulation of extracellular matrix disassembly	Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.		hp.json	regulation of extracellular matrix breakdown|regulation of extracellular matrix degradation	http://purl.obolibrary.org/obo/GO_0010715		
UBERON:0016928	biolink:AnatomicalEntity	metaphysis of fibula	A metaphysis that is part of a fibula.	FMA:33745	hp.json	fibular metaphysis|fibula metaphysis	http://purl.obolibrary.org/obo/UBERON_0016928		
GO:0071739	biolink:CellularComponent	IgD immunoglobulin complex, circulating	A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json	IgD antibody	http://purl.obolibrary.org/obo/GO_0071739		
GO:0071738	biolink:CellularComponent	IgD immunoglobulin complex	A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json		http://purl.obolibrary.org/obo/GO_0071738		
GO:0071736	biolink:CellularComponent	IgG immunoglobulin complex, circulating	A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json	IgG2a antibody|IgG1 antibody|IgG2 antibody|IgG2b antibody|IgG antibody|IgG2c antibody|IgG3 antibody|IgG4 antibody	http://purl.obolibrary.org/obo/GO_0071736		
GO:0071735	biolink:CellularComponent	IgG immunoglobulin complex	A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json	IgG4|IgG2c|IgG3|IgG2b|IgG2|IgG2a|IgG1	http://purl.obolibrary.org/obo/GO_0071735		
GO:0009725	biolink:BiologicalProcess	response to hormone	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.		hp.json	response to hormone stimulus|growth regulator	http://purl.obolibrary.org/obo/GO_0009725		
UBERON:0004952	biolink:AnatomicalEntity	submucosa of bronchiole	A submucosa that is part of a bronchiole [Automatically generated definition].	FMA:62775	hp.json	submucosa of lobular bronchiole|bronchiole submucosa|lobular bronchiole submucosa	http://purl.obolibrary.org/obo/UBERON_0004952		
HP:0041226	biolink:PhenotypicFeature	Fractured distal tarsal bone	A partial or complete breakage of the distal tarsal bone.		hp.json	bone distal tarsal bone	http://purl.obolibrary.org/obo/HP_0041226		
HP:0041227	biolink:PhenotypicFeature	Fractured distal tarsal bone 2	A partial or complete breakage of the distal tarsal bone 2.		hp.json	bone distal tarsal bone 2	http://purl.obolibrary.org/obo/HP_0041227		
HP:0041224	biolink:PhenotypicFeature	Fractured manual digit bone	A partial or complete breakage of the manual digit bone.		hp.json	bone manual digit bone	http://purl.obolibrary.org/obo/HP_0041224		
HP:0041225	biolink:PhenotypicFeature	Fractured metacarpal bone of digit 1	A partial or complete breakage of the metacarpal bone of digit 1.		hp.json	bone metacarpal bone of digit 1	http://purl.obolibrary.org/obo/HP_0041225		
HP:0004280	biolink:PhenotypicFeature	Irregular ossification of hand bones		UMLS:C4025374	hp.json	Irregular maturation of hand bones	http://purl.obolibrary.org/obo/HP_0004280		
HP:0041228	biolink:PhenotypicFeature	Fractured distal tarsal bone 3	A partial or complete breakage of the distal tarsal bone 3.		hp.json	bone distal tarsal bone 3	http://purl.obolibrary.org/obo/HP_0041228		
PATO:0000763	biolink:NamedThing	paralysed	A behavioral quality inhering in a bearer by virtue of the bearer's being affected by loss of the ability to move a body part.		hp.json	palsy	http://purl.obolibrary.org/obo/PATO_0000763		value_slim
HP:0004279	biolink:PhenotypicFeature	Short palm	Short palm.	UMLS:C1843108	hp.json	Short hands|Hypoplastic hands|Short palm|Short palms	http://purl.obolibrary.org/obo/HP_0004279		
HP:0004278	biolink:PhenotypicFeature	Synostosis involving bones of the hand	An abnormal union between bones or parts of bones of the hand.	UMLS:C4020831	hp.json	Fused hand bones	http://purl.obolibrary.org/obo/HP_0004278		
PATO:0000761	biolink:NamedThing	decreased behavioural activity	A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting reduced activity.		hp.json	hypoactive	http://purl.obolibrary.org/obo/PATO_0000761		value_slim
PATO:0000760	biolink:NamedThing	increased behavioural activity	A behavioral quality of a process inhering in a bearer by virtue of the bearer's exhibiting increased activity.		hp.json	hyperactive	http://purl.obolibrary.org/obo/PATO_0000760		value_slim
HP:0004273	biolink:PhenotypicFeature	Cupped metaphyses of hand bones		UMLS:C4025377	hp.json	Cupped metaphysis of hand bones|Cupped wide portion of hand bones	http://purl.obolibrary.org/obo/HP_0004273		
HP:0004272	biolink:PhenotypicFeature	Cortical thinning of hand bones		UMLS:C4025378	hp.json		http://purl.obolibrary.org/obo/HP_0004272		
NBO:0000100	biolink:NamedThing	exploration behavior			hp.json		http://purl.obolibrary.org/obo/NBO_0000100		
HP:0004271	biolink:PhenotypicFeature	Cortical thickening of hand bones		UMLS:C4025379	hp.json		http://purl.obolibrary.org/obo/HP_0004271		
HP:0004277	biolink:PhenotypicFeature	Fractured hand bones		UMLS:C0435632|SNOMEDCT_US:20511007	hp.json	Broken hand bones|Fractured hand bones	http://purl.obolibrary.org/obo/HP_0004277		
HP:0041222	biolink:PhenotypicFeature	Fractured fibula	A partial or complete breakage of the fibula.		hp.json	Fibula fracture|bone fibula|Broken fibula|Fracture of the fibula	http://purl.obolibrary.org/obo/HP_0041222		
HP:0004276	biolink:PhenotypicFeature	Exostoses of hand bones	Abnormal formation of new bone on the surface of a bone of the hand.	UMLS:C4025375	hp.json		http://purl.obolibrary.org/obo/HP_0004276		
HP:0041223	biolink:PhenotypicFeature	Fractured metatarsal bone of digit 5	A partial or complete breakage of the metatarsal bone of digit 5.		hp.json	bone metatarsal bone of digit 5	http://purl.obolibrary.org/obo/HP_0041223		
HP:0041220	biolink:PhenotypicFeature	Fractured facial bone	A partial or complete breakage of the facial bone.		hp.json	bone facial bone	http://purl.obolibrary.org/obo/HP_0041220		
HP:0004275	biolink:PhenotypicFeature	Duplication of hand bones		UMLS:C3276746	hp.json	Duplication of hand bones	http://purl.obolibrary.org/obo/HP_0004275		
HP:0004274	biolink:PhenotypicFeature	Deficient ossification of hand bones		UMLS:C4025376|UMLS:C4280534	hp.json	Deficient maturation of hand bones	http://purl.obolibrary.org/obo/HP_0004274		
HP:0041221	biolink:PhenotypicFeature	Fractured head of femur	A partial or complete breakage of the head of femur.		hp.json	bone head of femur	http://purl.obolibrary.org/obo/HP_0041221		
HP:0041237	biolink:PhenotypicFeature	Fractured patella	A partial or complete breakage of the patella.		hp.json	bone patella	http://purl.obolibrary.org/obo/HP_0041237		
HP:0041235	biolink:PhenotypicFeature	Fractured hindlimb bone	A partial or complete breakage of the hindlimb bone.		hp.json	bone hindlimb bone	http://purl.obolibrary.org/obo/HP_0041235		
HP:0041236	biolink:PhenotypicFeature	Fractured middle phalanx of manus	A partial or complete breakage of the middle phalanx of manus.		hp.json	bone middle phalanx of manus	http://purl.obolibrary.org/obo/HP_0041236		
HP:0004291	biolink:PhenotypicFeature	Stippled calcification of hand bones		UMLS:C4025365	hp.json		http://purl.obolibrary.org/obo/HP_0004291		
HP:0004290	biolink:PhenotypicFeature	Sclerosis of hand bones with transverse striations		UMLS:C4025366	hp.json		http://purl.obolibrary.org/obo/HP_0004290		
HP:0041239	biolink:PhenotypicFeature	Fractured manual digit 1 phalanx	A partial or complete breakage of the manual digit 1 phalanx.		hp.json	bone manual digit 1 phalanx	http://purl.obolibrary.org/obo/HP_0041239		
HP:0004289	biolink:PhenotypicFeature	Sclerotic foci in hand bones		UMLS:C4025367	hp.json		http://purl.obolibrary.org/obo/HP_0004289		
HP:0004284	biolink:PhenotypicFeature	Notched hand bones		UMLS:C4025372	hp.json	Notched hand bones	http://purl.obolibrary.org/obo/HP_0004284		
HP:0004283	biolink:PhenotypicFeature	Narrow palm	For children from birth to 4 years of age, the palm width is more than 2 SD below the mean; for children from 4 to 16 years of age the palm width is below the 5th centile; or, the width of the palm appears disproportionately narrow for its length.	UMLS:C1857632	hp.json	Narrow palm|Narrow hands|Narrow hand	http://purl.obolibrary.org/obo/HP_0004283		
HP:0041230	biolink:PhenotypicFeature	Fractured metatarsal bone of digit 4	A partial or complete breakage of the metatarsal bone of digit 4.		hp.json	bone metatarsal bone of digit 4	http://purl.obolibrary.org/obo/HP_0041230		
HP:0004281	biolink:PhenotypicFeature	Irregular sclerosis of hand bones		UMLS:C4025373	hp.json		http://purl.obolibrary.org/obo/HP_0004281		
HP:0004288	biolink:PhenotypicFeature	Pseudoepiphyses of hand bones		UMLS:C4025368	hp.json		http://purl.obolibrary.org/obo/HP_0004288		
HP:0041233	biolink:PhenotypicFeature	Fractured ilium	A partial or complete breakage of the ilium.		hp.json	bone ilium	http://purl.obolibrary.org/obo/HP_0041233		
HP:0004287	biolink:PhenotypicFeature	Pointed hand bones		UMLS:C4025369	hp.json	Pointed hand bones	http://purl.obolibrary.org/obo/HP_0004287		
HP:0041234	biolink:PhenotypicFeature	Fractured bone of jaw	A partial or complete breakage of the bone of jaw.		hp.json	bone bone of jaw	http://purl.obolibrary.org/obo/HP_0041234		
HP:0041231	biolink:PhenotypicFeature	Fractured metatarsal bone of digit 1	A partial or complete breakage of the metatarsal bone of digit 1.		hp.json	bone metatarsal bone of digit 1	http://purl.obolibrary.org/obo/HP_0041231		
HP:0004286	biolink:PhenotypicFeature	Patchy sclerosis of hand bones		UMLS:C4025370	hp.json	Uneven increase in bone density in hand bones	http://purl.obolibrary.org/obo/HP_0004286		
HP:0041232	biolink:PhenotypicFeature	obsolete Fractured skeleton of manual acropodium			hp.json		http://purl.obolibrary.org/obo/HP_0041232		
HP:0004285	biolink:PhenotypicFeature	Overmodelled hand bones		UMLS:C4025371	hp.json		http://purl.obolibrary.org/obo/HP_0004285		
HP:0041248	biolink:PhenotypicFeature	Fractured carpal bone	A partial or complete breakage of the carpal bone.		hp.json	Carpal bone fracture|Broken wrist|Wrist fracture|bone carpal bone|Fractured wrist	http://purl.obolibrary.org/obo/HP_0041248		
HP:0041249	biolink:PhenotypicFeature	Fractured nose	A partial or complete breakage of the nose.		hp.json	bone nose	http://purl.obolibrary.org/obo/HP_0041249		
HP:0041246	biolink:PhenotypicFeature	Fractured sternum	A partial or complete breakage of the sternum.		hp.json	bone sternum	http://purl.obolibrary.org/obo/HP_0041246		
HP:0041247	biolink:PhenotypicFeature	Fractured tarsal bone	A partial or complete breakage of the tarsal bone.		hp.json	bone tarsal bone	http://purl.obolibrary.org/obo/HP_0041247		
CHEBI:84729	biolink:ChemicalSubstance	hydroxyindoles	Any member of the class of  indoles carrying at least one hydroxy group.		hp.json		http://purl.obolibrary.org/obo/CHEBI_84729		3_STAR
HP:0004259	biolink:PhenotypicFeature	Abnormality of the hamate bone		UMLS:C4025386	hp.json		http://purl.obolibrary.org/obo/HP_0004259		
HP:0004258	biolink:PhenotypicFeature	Small trapezoid bone	Underdevelopment of the trapezoid.	UMLS:C4025387	hp.json		http://purl.obolibrary.org/obo/HP_0004258		
HP:0004257	biolink:PhenotypicFeature	Delayed ossification of the trapezoid bone	Formation of bone tissue of trapezoid is less than expected for age.	UMLS:C4021668	hp.json	Delayed maturation of the trapezoid bone	http://purl.obolibrary.org/obo/HP_0004257		
HP:0004256	biolink:PhenotypicFeature	Abnormality of the trapezoid bone		UMLS:C4025388	hp.json		http://purl.obolibrary.org/obo/HP_0004256		
HP:0004251	biolink:PhenotypicFeature	Lunate-triquetral fusion	Osseous fusion of the lunate and triquetrum.	UMLS:C1867930	hp.json	Lunotriquetral synostosis	http://purl.obolibrary.org/obo/HP_0004251		
HP:0041240	biolink:PhenotypicFeature	Fractured phalanx of pes	A partial or complete breakage of the phalanx of pes.		hp.json	bone phalanx of pes	http://purl.obolibrary.org/obo/HP_0041240		
HP:0041241	biolink:PhenotypicFeature	Fractured phalanx of manus	A partial or complete breakage of the phalanx of manus.		hp.json	bone phalanx of manus	http://purl.obolibrary.org/obo/HP_0041241		
HP:0004250	biolink:PhenotypicFeature	Proximally placed lunate		UMLS:C4025391	hp.json		http://purl.obolibrary.org/obo/HP_0004250		
HP:0004255	biolink:PhenotypicFeature	Small trapezium	Underdevelopment of the trapezium.	UMLS:C4025389	hp.json		http://purl.obolibrary.org/obo/HP_0004255		
HP:0041244	biolink:PhenotypicFeature	Fractured scapula	A partial or complete breakage of the scapula.		hp.json	bone scapula	http://purl.obolibrary.org/obo/HP_0041244		
HP:0041245	biolink:PhenotypicFeature	Fractured shoulder bone	A partial or complete breakage of the shoulder bone.		hp.json	bone shoulder bone	http://purl.obolibrary.org/obo/HP_0041245		
HP:0004254	biolink:PhenotypicFeature	Delayed ossification of the trapezium	Formation of bone tissue of trapezium is less than expected for age.	UMLS:C4021669	hp.json	Delayed maturation of the trapezium	http://purl.obolibrary.org/obo/HP_0004254		
HP:0004253	biolink:PhenotypicFeature	Absent trapezium		UMLS:C1847190	hp.json	Absent trapezium bone	http://purl.obolibrary.org/obo/HP_0004253		
HP:0041243	biolink:PhenotypicFeature	Fractured proximal phalanx of manus	A partial or complete breakage of the proximal phalanx of manus.		hp.json	bone proximal phalanx of manus	http://purl.obolibrary.org/obo/HP_0041243		
HP:0004252	biolink:PhenotypicFeature	Abnormality of the trapezium	An anomaly of trapezium.	UMLS:C4025390	hp.json		http://purl.obolibrary.org/obo/HP_0004252		
GO:0019172	biolink:MolecularActivity	glyoxalase III activity	Catalysis of the reaction: methylglyoxal + H2O = D-lactate.	EC:4.2.1.130|RHEA:27754|MetaCyc:GLYOXIII-RXN	hp.json	(R)-lactate hydro-lyase|D-lactate dehydratase|glutathione-independent glyoxalase activity	http://purl.obolibrary.org/obo/GO_0019172		
CHEBI:84735	biolink:ChemicalSubstance	algal metabolite	Any eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae.		hp.json	algal metabolites	http://purl.obolibrary.org/obo/CHEBI_84735		3_STAR
GO:0007186	biolink:BiologicalProcess	G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the  activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process.  The pathway can start from the plasma membrane, Golgi or nuclear membrane.		hp.json	G protein coupled receptor protein signalling pathway|dimeric G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway via GPCR dimer|G protein coupled receptor protein signaling pathway|G-protein coupled receptor protein signal transduction|G-protein coupled receptor protein signaling pathway|GPCR signalling pathway|dimeric G-protein coupled receptor signalling pathway|G-protein-coupled receptor protein signalling pathway|G-protein coupled receptor signalling pathway|GPCR signaling pathway	http://purl.obolibrary.org/obo/GO_0007186		goslim_drosophila
HP:0004269	biolink:PhenotypicFeature	Subluxation of the small joints of the hand	A partial dislocation of some or all of the small joints of the hand.	UMLS:C4025380	hp.json	Partial dislocation of small joints of hand	http://purl.obolibrary.org/obo/HP_0004269		
HP:0004268	biolink:PhenotypicFeature	Osteoarthritis of the small joints of the hand		UMLS:C4025381	hp.json		http://purl.obolibrary.org/obo/HP_0004268		
HP:0004267	biolink:PhenotypicFeature	Narrow small joints of the hand		UMLS:C4025382	hp.json	Narrow small joints of the hand	http://purl.obolibrary.org/obo/HP_0004267		
HP:0004262	biolink:PhenotypicFeature	Abnormality of the capitate bone		UMLS:C4025384	hp.json		http://purl.obolibrary.org/obo/HP_0004262		
HP:0004261	biolink:PhenotypicFeature	Wide hamate bone		UMLS:C4021667	hp.json	Wide unciform bone|Broad hamate bone	http://purl.obolibrary.org/obo/HP_0004261		
HP:0004260	biolink:PhenotypicFeature	Large hamate bone		UMLS:C4025385	hp.json	Large unciform bone	http://purl.obolibrary.org/obo/HP_0004260		
HP:0004264	biolink:PhenotypicFeature	Narrow carpal joint spaces		UMLS:C4021666	hp.json	Decreased carpal joint angles	http://purl.obolibrary.org/obo/HP_0004264		
HP:0004263	biolink:PhenotypicFeature	Large capitate bone		UMLS:C4025383	hp.json		http://purl.obolibrary.org/obo/HP_0004263		
GO:0007159	biolink:BiologicalProcess	leukocyte cell-cell adhesion	The attachment of a leukocyte to another cell via adhesion molecules.		hp.json	leukocyte adhesion|leukocyte cell adhesion	http://purl.obolibrary.org/obo/GO_0007159		
HP:0031860	biolink:PhenotypicFeature	Abnormal heart rate variability	Any abnormality in the variability of the time interval between successive heartbeats.		hp.json		http://purl.obolibrary.org/obo/HP_0031860		
HP:0031861	biolink:PhenotypicFeature	Decreased heart rate variability	Reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle.		hp.json	Reduced heart rate variability	http://purl.obolibrary.org/obo/HP_0031861		
HP:0031862	biolink:PhenotypicFeature	Increased heart rate variability	Increased variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle.		hp.json		http://purl.obolibrary.org/obo/HP_0031862		
GO:0007155	biolink:BiologicalProcess	cell adhesion	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.	Wikipedia:Cell_adhesion	hp.json	single organism cell adhesion|cell adhesion molecule activity	http://purl.obolibrary.org/obo/GO_0007155		goslim_candida|goslim_generic|prokaryote_subset|goslim_pombe|goslim_pir|goslim_drosophila|goslim_aspergillus|goslim_chembl|goslim_metagenomics
GO:0007154	biolink:BiologicalProcess	cell communication	Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.	Wikipedia:Cell_signaling	hp.json		http://purl.obolibrary.org/obo/GO_0007154		goslim_plant|goslim_pir
HP:0031867	biolink:PhenotypicFeature	Neck hypertonia	Increased passive stiffness or tightness of the neck musculature.		hp.json		http://purl.obolibrary.org/obo/HP_0031867		
GO:0007162	biolink:BiologicalProcess	negative regulation of cell adhesion	Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.		hp.json	cell adhesion receptor inhibitor activity|down-regulation of cell adhesion|down regulation of cell adhesion|inhibition of cell adhesion|downregulation of cell adhesion	http://purl.obolibrary.org/obo/GO_0007162		
HP:0031868	biolink:PhenotypicFeature	Optic ataxia	Difficulty reaching to visually guided goals in peripheral vision, with the deficit leaves voluntary eye movements largely unaffected.		hp.json		http://purl.obolibrary.org/obo/HP_0031868		
HP:0031869	biolink:PhenotypicFeature	Recurrent joint dislocation	Dislocation of a given joint repeated times.		hp.json	Recurrent joint dislocations	http://purl.obolibrary.org/obo/HP_0031869		
HP:0031863	biolink:PhenotypicFeature	Bloodstream infectious agent	The presence of an infectious agent in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031863		
HP:0031864	biolink:PhenotypicFeature	Bacteremia	Presence of viable bacteria in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031864		
HP:0031865	biolink:PhenotypicFeature	Abnormal liver physiology	Any functional anomaly of the liver.		hp.json	Abnormal hepatic physiology	http://purl.obolibrary.org/obo/HP_0031865		
HP:0031866	biolink:PhenotypicFeature	Clasp-knife sign	Clasp-knife phenomonen refers to increased muscle tone while bending or stretching a limb, whereby there is a sudden relaxation (decrease in resistance) as the muscle continues to be streched. This phenomenon has been likened to opening a clasp knife.		hp.json		http://purl.obolibrary.org/obo/HP_0031866		
GO:0032109	biolink:BiologicalProcess	positive regulation of response to nutrient levels	Any process that activates or increases the frequency, rate or extent of a response to nutrient levels.		hp.json	up-regulation of response to nutrient levels|up regulation of response to nutrient levels|activation of response to nutrient levels|stimulation of response to nutrient levels|upregulation of response to nutrient levels	http://purl.obolibrary.org/obo/GO_0032109		
GO:0032108	biolink:BiologicalProcess	negative regulation of response to nutrient levels	Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels.		hp.json	downregulation of response to nutrient levels|inhibition of response to nutrient levels|down-regulation of response to nutrient levels|down regulation of response to nutrient levels	http://purl.obolibrary.org/obo/GO_0032108		
GO:0032107	biolink:BiologicalProcess	regulation of response to nutrient levels	Any process that modulates the frequency, rate or extent of a response to nutrient levels.		hp.json		http://purl.obolibrary.org/obo/GO_0032107		
GO:0032106	biolink:BiologicalProcess	positive regulation of response to extracellular stimulus	Any process that activates, maintains or increases the rate of a response to an extracellular stimulus.		hp.json	stimulation of response to extracellular stimulus|up-regulation of response to extracellular stimulus|activation of response to extracellular stimulus|upregulation of response to extracellular stimulus|up regulation of response to extracellular stimulus	http://purl.obolibrary.org/obo/GO_0032106		
GO:0032105	biolink:BiologicalProcess	negative regulation of response to extracellular stimulus	Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus.		hp.json	downregulation of response to extracellular stimulus|down regulation of response to extracellular stimulus|inhibition of response to extracellular stimulus|down-regulation of response to extracellular stimulus	http://purl.obolibrary.org/obo/GO_0032105		
GO:0034767	biolink:BiologicalProcess	positive regulation of ion transmembrane transport	Any process that activates or increases the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.		hp.json	up-regulation of transmembrane ion transport|up regulation of transmembrane ion transport|activation of transmembrane ion transport|positive regulation of transmembrane ion transport|stimulation of transmembrane ion transport|positive regulation of ion membrane transport|upregulation of transmembrane ion transport	http://purl.obolibrary.org/obo/GO_0034767		
HP:0031870	biolink:PhenotypicFeature	Phosphohydroxylysinuria	An elevated concentration of phosphohydroxylysine in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031870		
HP:0031871	biolink:PhenotypicFeature	Abnormal Langerhans cell morphology	Any functional anomaly of Langerhans cells, which are dendritic cells in the epidermis and some other locations. Langerhans cells play roles in immune surveillance and homeostasis.		hp.json		http://purl.obolibrary.org/obo/HP_0031871		
GO:0034769	biolink:BiologicalProcess	basement membrane disassembly	The controlled breakdown of the basement membrane in the context of a normal process such as imaginal disc eversion.		hp.json	basal lamina disassembly	http://purl.obolibrary.org/obo/GO_0034769		
HP:0031872	biolink:PhenotypicFeature	Absent Birbeck granules in Langerhans cells	Birbeck granules (BG) are cytoplasmic organelles that are only found in Langerhans cells (LC). The function of BG is still not completely understood, although most studies point toward an active role in receptor-mediated endocytosis and participation in the antigen-processing/presenting function of LC. This feature refers to the absence of BG in LC, a feature that can be documented by means of electron microscopy.		hp.json		http://purl.obolibrary.org/obo/HP_0031872		
HP:0031873	biolink:PhenotypicFeature	Early chronotype	A tendency towards rising very early in the morning and going to bed early in the evening.		hp.json	Early sleep onset	http://purl.obolibrary.org/obo/HP_0031873		
GO:0007166	biolink:BiologicalProcess	cell surface receptor signaling pathway	The series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.		hp.json	cell surface receptor linked signalling pathway|cell surface receptor linked signal transduction|cell surface receptor linked signaling pathway	http://purl.obolibrary.org/obo/GO_0007166		goslim_drosophila
GO:0007165	biolink:BiologicalProcess	signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.	Wikipedia:Signal_transduction	hp.json	signal transduction by trans-phosphorylation|signalling cascade|signal transduction by protein phosphorylation|signaling cascade|signal transduction by conformational transition|signal transduction by cis-phosphorylation|signalling pathway|signaling pathway	http://purl.obolibrary.org/obo/GO_0007165		goslim_plant|goslim_aspergillus|goslim_chembl|goslim_metagenomics|goslim_candida
GO:0007163	biolink:BiologicalProcess	establishment or maintenance of cell polarity	Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.		hp.json	establishment and/or maintenance of cell polarity|cell polarity|establishment and/or maintenance of cell polarization	http://purl.obolibrary.org/obo/GO_0007163		goslim_pombe|goslim_drosophila|goslim_generic
HP:0031878	biolink:PhenotypicFeature	Acromicria	Small hands and feet in proportion to the rest of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0031878		
GO:0034760	biolink:BiologicalProcess	negative regulation of iron ion transmembrane transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore.		hp.json	negative regulation of transmembrane iron ion transport|negative regulation of transmembrane iron transport|downregulation of transmembrane iron ion transport|down regulation of transmembrane iron ion transport|negative regulation of iron ion membrane transport|inhibition of transmembrane iron ion transport|down-regulation of transmembrane iron ion transport	http://purl.obolibrary.org/obo/GO_0034760		
HP:0031879	biolink:PhenotypicFeature	Abnormal eyelid physiology	Any functional abnormality of the eyelid.		hp.json		http://purl.obolibrary.org/obo/HP_0031879		
GO:0034761	biolink:BiologicalProcess	positive regulation of iron ion transmembrane transport	Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions from one side of a membrane to the other by means of some agent such as a transporter or pore.		hp.json	up regulation of transmembrane iron ion transport|stimulation of transmembrane iron ion transport|positive regulation of transmembrane iron ion transport|up-regulation of transmembrane iron ion transport|positive regulation of iron ion membrane transport|activation of transmembrane iron ion transport|positive regulation of transmembrane iron transport|upregulation of transmembrane iron ion transport	http://purl.obolibrary.org/obo/GO_0034761		
GO:0034762	biolink:BiologicalProcess	regulation of transmembrane transport	Any process that modulates the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.		hp.json	regulation of membrane transport	http://purl.obolibrary.org/obo/GO_0034762		
HP:0031874	biolink:PhenotypicFeature	Late chronotype	A tendency towards rising very late in the morning and going to bed late at night.		hp.json	Late sleep onset	http://purl.obolibrary.org/obo/HP_0031874		
GO:0034763	biolink:BiologicalProcess	negative regulation of transmembrane transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.		hp.json	negative regulation of membrane transport|down-regulation of transmembrane transport|down regulation of transmembrane transport|downregulation of transmembrane transport|inhibition of transmembrane transport	http://purl.obolibrary.org/obo/GO_0034763		
GO:0034764	biolink:BiologicalProcess	positive regulation of transmembrane transport	Any process that activates or increases the frequency, rate or extent of the directed movement of a solute from one side of a membrane to the other.		hp.json	activation of transmembrane transport|stimulation of transmembrane transport|upregulation of transmembrane transport|positive regulation of membrane transport|up-regulation of transmembrane transport|up regulation of transmembrane transport	http://purl.obolibrary.org/obo/GO_0034764		
HP:0031875	biolink:PhenotypicFeature	Abnormal hepcidin level	Any deviation from the normal concentration of hepcidin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031875		
HP:0031876	biolink:PhenotypicFeature	Decreased hepcidin level	An abnormally reduced concentration of hepcidin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031876		
GO:0034765	biolink:BiologicalProcess	regulation of ion transmembrane transport	Any process that modulates the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.		hp.json	regulation of ion membrane transport|regulation of transmembrane ion transport	http://purl.obolibrary.org/obo/GO_0034765		
GO:0034766	biolink:BiologicalProcess	negative regulation of ion transmembrane transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of ions from one side of a membrane to the other.		hp.json	down regulation of transmembrane ion transport|negative regulation of transmembrane ion transport|inhibition of transmembrane ion transport|downregulation of transmembrane ion transport|negative regulation of ion membrane transport|down-regulation of transmembrane ion transport	http://purl.obolibrary.org/obo/GO_0034766		
HP:0031877	biolink:PhenotypicFeature	Elevated hepcidin level	An abnormally increased concentration of hepcidin in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031877		
GO:0032104	biolink:BiologicalProcess	regulation of response to extracellular stimulus	Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0032104		
GO:0032103	biolink:BiologicalProcess	positive regulation of response to external stimulus	Any process that activates, maintains or increases the rate of a response to an external stimulus.		hp.json	stimulation of response to external stimulus|upregulation of response to external stimulus|up-regulation of response to external stimulus|up regulation of response to external stimulus|activation of response to external stimulus	http://purl.obolibrary.org/obo/GO_0032103		gocheck_do_not_manually_annotate
GO:0032102	biolink:BiologicalProcess	negative regulation of response to external stimulus	Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.		hp.json	down-regulation of response to external stimulus|down regulation of response to external stimulus|inhibition of response to external stimulus|downregulation of response to external stimulus	http://purl.obolibrary.org/obo/GO_0032102		gocheck_do_not_manually_annotate
GO:0032101	biolink:BiologicalProcess	regulation of response to external stimulus	Any process that modulates the frequency, rate or extent of a response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0032101		gocheck_do_not_manually_annotate
NBO:0000119	biolink:NamedThing	impulsive behavior	"A behavior that occur quickly without control, planning, or consideration of the consequences of that behavior." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000119		
HP:0041209	biolink:PhenotypicFeature	Fractured epiphysis of middle phalanx of manus	A partial or complete breakage of the epiphysis of middle phalanx of manus.		hp.json	bone epiphysis of middle phalanx of manus	http://purl.obolibrary.org/obo/HP_0041209		
GO:0034756	biolink:BiologicalProcess	regulation of iron ion transport	Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	regulation of Fe transport|regulation of iron ion import|regulation of iron transport|regulation of iron import	http://purl.obolibrary.org/obo/GO_0034756		
HP:0031881	biolink:PhenotypicFeature	Decreased tear drainage	A form of watery eye associated with obstruction of the nasolacrimal system. This may arise at the level of the punctum, the canaliculi, the sac or the nasolacrimal duct.		hp.json		http://purl.obolibrary.org/obo/HP_0031881		
GO:0034757	biolink:BiologicalProcess	negative regulation of iron ion transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	downregulation of iron ion transport|down regulation of iron ion transport|inhibition of iron ion transport|down-regulation of iron ion transport|negative regulation of iron transport	http://purl.obolibrary.org/obo/GO_0034757		
HP:0031882	biolink:PhenotypicFeature	Agyria	A congenital abnormality of the cerebral hemisphere characterized by lack of gyrations (convolutions) of the cerebral cortex. Agyria is defined as cortical regions lacking gyration with sulci great than 3 cm apart and cerebral cortex thicker than 5 mm.		hp.json	Agyria diffuse	http://purl.obolibrary.org/obo/HP_0031882		
HP:0031883	biolink:PhenotypicFeature	Increased proinsulin:insulin ratio	An elevated concentration of proinsulin (the prohormone precursor to insulin) to mature insulin in the circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031883		
GO:0034758	biolink:BiologicalProcess	positive regulation of iron ion transport	Any process that activates or increases the frequency, rate or extent of the directed movement of iron ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	up-regulation of iron ion transport|activation of iron ion transport|positive regulation of iron transport|upregulation of iron ion transport|up regulation of iron ion transport|stimulation of iron ion transport	http://purl.obolibrary.org/obo/GO_0034758		
HP:0031884	biolink:PhenotypicFeature	Abnormal CSF glucose concentration	A deviation from normal concentration of glucose content in the cerebrospinal fluid.		hp.json	Abnormal CSF glucose level	http://purl.obolibrary.org/obo/HP_0031884		
GO:0034759	biolink:BiologicalProcess	regulation of iron ion transmembrane transport	Any process that modulates the frequency, rate or extent of the directed movement of iron ions (Fe) from one side of a membrane to the other by means of some agent such as a transporter or pore.		hp.json	regulation of transmembrane iron ion transport|regulation of iron ion membrane transport|regulation of transmembrane iron transport|regulation of transmembrane Fe transport	http://purl.obolibrary.org/obo/GO_0034759		
HP:0031880	biolink:PhenotypicFeature	Eyelid laxity	Abnormally lax eyelid associated with tissue relaxation; it can be demonstrated by the eyelid distraction test and/or the eyelid snap test.		hp.json	Lid laxity	http://purl.obolibrary.org/obo/HP_0031880		
GO:0009792	biolink:BiologicalProcess	embryo development ending in birth or egg hatching	The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.		hp.json	embryogenesis	http://purl.obolibrary.org/obo/GO_0009792		
HP:0031889	biolink:PhenotypicFeature	Abnormal VLDL cholesterol concentration	Any deviation from the normal concentration of very-low-density lipoprotein cholesterol in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031889		
GO:0007140	biolink:NamedThing	male meiotic nuclear division			hp.json		http://purl.obolibrary.org/obo/GO_0007140		
HP:0031885	biolink:PhenotypicFeature	Hyperglycorrhachia	Abnormally high glucose concentration in the cerebrospinal fluid.		hp.json	Increased CSF glucose	http://purl.obolibrary.org/obo/HP_0031885		
HP:0031886	biolink:PhenotypicFeature	Abnormal LDL cholesterol concentration	Any deviation from the normal concentration of low-density lipoprotein cholesterol in the blood circulation.		hp.json	Abnormal LDLc concentration|Abnormal LDL-C concentration|Abnormal LDL-C level	http://purl.obolibrary.org/obo/HP_0031886		
HP:0031887	biolink:PhenotypicFeature	Abnormal chylomicron concentration	Any deviation from the normal circulating concentration of chylomicrons.		hp.json		http://purl.obolibrary.org/obo/HP_0031887		
GO:0034754	biolink:NamedThing	cellular hormone metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0034754		
GO:0034755	biolink:BiologicalProcess	iron ion transmembrane transport	A process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.		hp.json	high-affinity iron ion transport|iron ion membrane transport|low affinity iron ion transport|iron(2+) transmembrane transport|high affinity iron ion transport|low-affinity iron ion transmembrane transport|high-affinity iron ion transmembrane transport|high affinity ferrous ion transmembrane transport|transmembrane iron transport|ferrous iron transmembrane transport|high-affinity ferrous ion transmembrane transport|ferrous ion transmembrane transport|low-affinity iron ion transport	http://purl.obolibrary.org/obo/GO_0034755		
HP:0031888	biolink:PhenotypicFeature	Abnormal HDL cholesterol concentration	Any deviation from the normal concentration of high-density lipoprotein cholesterol (HDL) in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031888		
HP:0004295	biolink:PhenotypicFeature	Abnormal gastric mucosa morphology	An abnormality of the gastric mucous membrane.	UMLS:C4025362	hp.json	Abnormality of the mucous membrane layer of stomach|Abnormality of the gastric mucosa	http://purl.obolibrary.org/obo/HP_0004295		
HP:0004294	biolink:PhenotypicFeature	Subluxation of metacarpal phalangeal joints	A partial dislocation affecting some or all of the metacarpophalangeal joints.	UMLS:C4025363	hp.json	Subluxation of metacarpophalangeal joints|Partial knuckle dislocation	http://purl.obolibrary.org/obo/HP_0004294		
HP:0004293	biolink:PhenotypicFeature	Synostosis of second metacarpal-trapezoid	Fusion of the second metacarpal-trapezoid.	UMLS:C4021665	hp.json	Fusion of second metacarpal-trapezoid	http://purl.obolibrary.org/obo/HP_0004293		
HP:0004292	biolink:PhenotypicFeature	Undermodelled hand bones		UMLS:C4025364	hp.json		http://purl.obolibrary.org/obo/HP_0004292		
NBO:0000121	biolink:NamedThing	agonistic behavior			hp.json	agonism	http://purl.obolibrary.org/obo/NBO_0000121		
HP:0004299	biolink:PhenotypicFeature	Hernia of the abdominal wall	The presence of a hernia in the abdominal wall.	SNOMEDCT_US:128545000|Fyler:4414|UMLS:C1442978	hp.json	Herniated abdominal wall	http://purl.obolibrary.org/obo/HP_0004299		hposlim_core
NBO:0000120	biolink:NamedThing	physical aggression behavior	"An aggressive behavior that aims to inflicting damage on another entity using physical means." [NBO:GVG]		hp.json	physical aggression behaviour|violent behaviour	http://purl.obolibrary.org/obo/NBO_0000120		
HP:0041200	biolink:PhenotypicFeature	Fractured sternal end of clavicle	A partial or complete breakage of the sternal end of clavicle.		hp.json	bone sternal end of clavicle	http://purl.obolibrary.org/obo/HP_0041200		
HP:0004298	biolink:PhenotypicFeature	Abnormality of the abdominal wall	The presence of any abnormality affecting the abdominal wall.	UMLS:C4021664	hp.json	Abnormality of external features of the abdomen|Abnormality of the abdominal wall	http://purl.obolibrary.org/obo/HP_0004298		hposlim_core
HP:0004297	biolink:PhenotypicFeature	Abnormality of the biliary system	An abnormality of the biliary system.	UMLS:C0940767	hp.json		http://purl.obolibrary.org/obo/HP_0004297		
HP:0004296	biolink:PhenotypicFeature	Abnormal gastrointestinal vascular morphology		UMLS:C4025361	hp.json	Abnormality of GI vasculature|Abnormality of GI blood vessels|Abnormality of gastrointestinal vasculature	http://purl.obolibrary.org/obo/HP_0004296		
HP:0041215	biolink:PhenotypicFeature	Fractured fused metatarsal bones 2-4	A partial or complete breakage of the fused metatarsal bones 2-4.		hp.json	bone fused metatarsal bones 2-4	http://purl.obolibrary.org/obo/HP_0041215		
HP:0041216	biolink:PhenotypicFeature	Fractured distal epiphysis of distal phalanx of manual digit 1	A partial or complete breakage of the distal epiphysis of distal phalanx of manual digit 1.		hp.json	bone distal epiphysis of distal phalanx of manual digit 1	http://purl.obolibrary.org/obo/HP_0041216		
HP:0041213	biolink:PhenotypicFeature	Fractured proximal phalanx of digit 4	A partial or complete breakage of the proximal phalanx of digit 4.		hp.json	bone proximal phalanx of digit 4	http://purl.obolibrary.org/obo/HP_0041213		
HP:0041214	biolink:PhenotypicFeature	Fractured proximal phalanx of digit 5	A partial or complete breakage of the proximal phalanx of digit 5.		hp.json	bone proximal phalanx of digit 5	http://purl.obolibrary.org/obo/HP_0041214		
NBO:0000129	biolink:NamedThing	agitation behavior	"Emotional behavior related to excitement or restlessness." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000129		
NBO:0000128	biolink:NamedThing	irritability behavior	"Behavior characterized by a quick excitability to annoyance, impatience, or anger." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000128		
HP:0041219	biolink:PhenotypicFeature	Fractured elbow	A partial or complete breakage of the elbow.		hp.json	bone elbow	http://purl.obolibrary.org/obo/HP_0041219		
HP:0041217	biolink:PhenotypicFeature	Fractured shoulder	A fracture or multiple fractures of the humerus (ball) or the glenoid (socket) of the shoulder joint.		hp.json	bone shoulder joint	http://purl.obolibrary.org/obo/HP_0041217		
HP:0041218	biolink:PhenotypicFeature	Fractured distal phalanx	A partial or complete breakage of the distal phalanx.		hp.json	bone distal phalanx	http://purl.obolibrary.org/obo/HP_0041218		
GO:0007143	biolink:BiologicalProcess	female meiotic nuclear division	A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.		hp.json	female meiosis|female meiotic division	http://purl.obolibrary.org/obo/GO_0007143		
HP:0031890	biolink:PhenotypicFeature	Increased urine urobilinogen	An elevated concentration of urobilinogen in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031890		
HP:0031891	biolink:PhenotypicFeature	Decreased eosinophil count	Abnormal reduction in the count of eosinophils in the blood per volume.		hp.json		http://purl.obolibrary.org/obo/HP_0031891		
GO:0046717	biolink:BiologicalProcess	acid secretion	The controlled release of acid by a cell or a tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0046717		
GO:0046716	biolink:BiologicalProcess	muscle cell cellular homeostasis	The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.		hp.json	muscle fiber maintenance|muscle homeostasis	http://purl.obolibrary.org/obo/GO_0046716		
HP:0031898	biolink:PhenotypicFeature	Rouleaux formation	Increased amount of stacking of erythrocytes into long chains. Rouleaux (singular: rouleau) is derived from a French word that can refer to a stack of coins put into a cylindircal paper roll. Rouleaux formation is observed with increased serum proteins, particularly fibrinogen and globulins, and represents the cause of increased erythrocte sedimentation rate because rouleaux sediment more readily than isolated red blood cells.		hp.json	Increased rouleaux formation	http://purl.obolibrary.org/obo/HP_0031898		
HP:0031899	biolink:PhenotypicFeature	Abnormal coagulation factor V activity	Any deviation from the activity of coagulation factor V.		hp.json	Abnormal factor V activity	http://purl.obolibrary.org/obo/HP_0031899		
NBO:0000134	biolink:NamedThing	food consumption	"A feeding behavior associated with the intake of food." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000134		
NBO:0000133	biolink:NamedThing	liquid preference/aversion			hp.json		http://purl.obolibrary.org/obo/NBO_0000133		
HP:0041211	biolink:PhenotypicFeature	Fractured proximal phalanx of digit 2	A partial or complete breakage of the proximal phalanx of digit 2.		hp.json	bone proximal phalanx of digit 2	http://purl.obolibrary.org/obo/HP_0041211		
NBO:0000130	biolink:NamedThing	liquid consumption	"A behavior associated with the intake of liquid." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000130		
HP:0041212	biolink:PhenotypicFeature	Fractured proximal phalanx of digit 3	A partial or complete breakage of the proximal phalanx of digit 3.		hp.json	bone proximal phalanx of digit 3	http://purl.obolibrary.org/obo/HP_0041212		
HP:0041210	biolink:PhenotypicFeature	Fractured lateral malleolus of fibula	A partial or complete breakage of the lateral malleolus of fibula.		hp.json	bone lateral malleolus of fibula	http://purl.obolibrary.org/obo/HP_0041210		
HP:0031823	biolink:PhenotypicFeature	Reduced hypoxanthine-guanine phosphoribosyltransferase level	Abnormally decreased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.		hp.json	Reduced 6-mercaptopurine phosphoribosyltransferase level|Reduced 6-hydroxypurine phosphoribosyltransferase level|Reduced GMP pyrophosphorylase level	http://purl.obolibrary.org/obo/HP_0031823		
HP:0031824	biolink:PhenotypicFeature	Hepatic mastocytosis	Liver mast cell infiltration.		hp.json		http://purl.obolibrary.org/obo/HP_0031824		
HP:0006858	biolink:PhenotypicFeature	Impaired distal proprioception	A loss or impairment of the sensation of the relative position of parts of the body and joint position occuring at distal joints.	UMLS:C4021585	hp.json	Distal sensory loss of proprioception	http://purl.obolibrary.org/obo/HP_0006858		
HP:0031825	biolink:PhenotypicFeature	Freezing of gait	Freezing of gait is defined as a brief, episodic absence or marked reduction of forward progression of the feet despite the intention to walk.		hp.json	Freezing gait	http://purl.obolibrary.org/obo/HP_0031825		
HP:0006859	biolink:PhenotypicFeature	Posterior leukoencephalopathy		UMLS:C4024975	hp.json		http://purl.obolibrary.org/obo/HP_0006859		
HP:0031826	biolink:PhenotypicFeature	Abnormal reflex	Any anomaly of a reflex, i.e., of an automatic response mediated by the nervous system (a reflex does not need the intervention of conscious thought to occur).		hp.json		http://purl.obolibrary.org/obo/HP_0031826		
HP:0006852	biolink:PhenotypicFeature	Episodic generalized hypotonia	The occurrence of repeated episodes of generalized muscular hypotonia.	UMLS:C4024976	hp.json	Episodic generalised hypotonia	http://purl.obolibrary.org/obo/HP_0006852		
HP:0031820	biolink:PhenotypicFeature	Decreased waist to hip ratio	Decreased waist-to-hip ratio (WHR) is a measurement below the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement.		hp.json	Decreased WHR|Decreased waist-hip ratio|Decreased waist-to-hip ratio	http://purl.obolibrary.org/obo/HP_0031820		
HP:0031821	biolink:PhenotypicFeature	Abnormal hypoxanthine-guanine phosphoribosyltransferase level	Altered level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.		hp.json	Abnormal GPRT level|Abnormal 6-hydroxypurine phosphoribosyltransferase level|Abnormal GMP pyrophosphorylase level	http://purl.obolibrary.org/obo/HP_0031821		
HP:0031822	biolink:PhenotypicFeature	Elevated hypoxanthine-guanine phosphoribosyltransferase level	Abnormally increased level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate.		hp.json	Elevated 6-mercaptopurine phosphoribosyltransferase level|Elevated 6-hydroxypurine phosphoribosyltransferase level|Elevated GMP pyrophosphorylase level	http://purl.obolibrary.org/obo/HP_0031822		
HP:0006855	biolink:PhenotypicFeature	Cerebellar vermis atrophy	Wasting (atrophy) of the vermis of cerebellum.	UMLS:C0742028	hp.json	Vermian atrophy|Atrophy of the cerebellar vermis|Atrophy of cerebellar vermis	http://purl.obolibrary.org/obo/HP_0006855		
HP:0006850	biolink:PhenotypicFeature	Hypoplasia of the ventral pons	Underdevelopment of the ventral portion of the pons.	UMLS:C1843507	hp.json	Underdeveloped ventral pons	http://purl.obolibrary.org/obo/HP_0006850		
HP:0006851	biolink:PhenotypicFeature	Symmetric spinal nerve root neurofibromas	Multiple neurofibromas of the spinal nerve roots with a symmetric distribution.	UMLS:C1834236	hp.json	Spinal nerve root neurofibromas, symmetric, multiple	http://purl.obolibrary.org/obo/HP_0006851		
HP:0031827	biolink:PhenotypicFeature	Absent abdominal reflex	Lack of contraction of abdominal muscles in the quadrant of the abdomen that is stimulated by scraping the skin tangential to or toward the umbilicus.		hp.json	Abdominal reflex absent	http://purl.obolibrary.org/obo/HP_0031827		
HP:0031828	biolink:PhenotypicFeature	Abnormal superficial reflex	An anomaly of a reflex that is elicited as a motor response to scraping of the skin. They are generally graded as present or absent. They differ from tendon reflexes in that the sensory signal must ascend the spinal cord to reach the brain and then descend the spinal cord to reach the motor neurons.		hp.json		http://purl.obolibrary.org/obo/HP_0031828		
HP:0031829	biolink:PhenotypicFeature	Absent cremaster reflex	Lack of response to scratching of the skin of the medial thigh, which in males normally elicits a brisk, short elevation of the ipsilateral testis, a phenomenon that is referred to as the cremaster reflex.		hp.json	Absent cremasteric reflex	http://purl.obolibrary.org/obo/HP_0031829		
CHEBI:35703	biolink:ChemicalSubstance	xenobiotic	A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.	Wikipedia:Xenobiotic|KEGG:C06708	hp.json	xenobiotic|xenobiotics|Xenobiotic|xenobiotic compounds	http://purl.obolibrary.org/obo/CHEBI_35703		3_STAR
HP:0004209	biolink:PhenotypicFeature	Clinodactyly of the 5th finger	Clinodactyly refers to a bending or curvature of the fifth finger in the radial direction (i.e., towards the 4th finger).	UMLS:C4280538|UMLS:C1850049	hp.json	Permanent curving of the pinkie finger|Curvature of pinkie finger|Curvature of pinky finger|Curvature of little finger|Bilateral fifth finger clinodactyly|Fifth finger clinodactyly|Clinodactyly of fifth digit|Clinodactyly of the little finger|Bilateral fifth digit clinodactyly	http://purl.obolibrary.org/obo/HP_0004209		
HP:0031834	biolink:PhenotypicFeature	Aortopulmonary collateral arteries	Small ectopic arteries or arterial branches that connect the aorta, aortic branches and/or subclavian artery regions directly to the lung parenchyma, usually seen in conjunction with pulmonary atresia, ventricular septal defect (VSD) and/or closed ductus arteriosus.		hp.json		http://purl.obolibrary.org/obo/HP_0031834		
HP:0004203	biolink:PhenotypicFeature	obsolete Short proximal phalanx of the ring finger			hp.json		http://purl.obolibrary.org/obo/HP_0004203		
HP:0031835	biolink:PhenotypicFeature	Abnormal superoxide dismutase level	An abnormal level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.		hp.json	Abnormal superoxide:superoxide oxidoreductase activity	http://purl.obolibrary.org/obo/HP_0031835		
HP:0031836	biolink:PhenotypicFeature	Increased superoxide dismutase level	Increased level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.		hp.json	Increased superoxide:superoxide oxidoreductase activity	http://purl.obolibrary.org/obo/HP_0031836		
HP:0004202	biolink:PhenotypicFeature	obsolete Lytic defects of the proximal phalanx of the ring finger			hp.json		http://purl.obolibrary.org/obo/HP_0004202		
HP:0004201	biolink:PhenotypicFeature	obsolete Expanded proximal phalanx of the ring finger			hp.json		http://purl.obolibrary.org/obo/HP_0004201		
HP:0031837	biolink:PhenotypicFeature	Decreased superoxide dismutase level	Decreased level of catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.		hp.json	Decreased superoxide:superoxide oxidoreductase activity	http://purl.obolibrary.org/obo/HP_0031837		
HP:0031830	biolink:PhenotypicFeature	Pinguecula	A pinguecula is a yellowish to brown protruding lesion in the conjunctiva that is easily seen on the nasal and temporal sides of the cornea.		hp.json		http://purl.obolibrary.org/obo/HP_0031830		
HP:0006863	biolink:PhenotypicFeature	Severe expressive language delay	A severe delay in the acquisition of the ability to use language to communicate needs, wishes, or thoughts.	UMLS:C1851085|SNOMEDCT_US:62221000119105	hp.json		http://purl.obolibrary.org/obo/HP_0006863		
HP:0004207	biolink:PhenotypicFeature	Abnormal 5th finger morphology	An abnormality affecting one or both 5th fingers.	UMLS:C4021678	hp.json	Abnormality of the 5th finger|Abnormality of the pinky finger|Abnormality of the little finger|Abnormality of the pinkie finger	http://purl.obolibrary.org/obo/HP_0004207		
HP:0031831	biolink:PhenotypicFeature	Decreased serum zinc	A reduced concentration of zinc in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0031831		
HP:0006865	biolink:PhenotypicFeature	Sensorimotor polyneuropathy affecting arms more than legs		UMLS:C4024974	hp.json		http://purl.obolibrary.org/obo/HP_0006865		
HP:0031832	biolink:PhenotypicFeature	Hypermetric downward saccades	Overshoot of downward saccadic eye movements.		hp.json		http://purl.obolibrary.org/obo/HP_0031832		
CHEBI:35701	biolink:ChemicalSubstance	ester	A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter.	Wikipedia:Ester|KEGG:C00287	hp.json	esters|Ester	http://purl.obolibrary.org/obo/CHEBI_35701		3_STAR
HP:0031833	biolink:PhenotypicFeature	Hypometric upward saccades	Saccadic undershoot of upward saccadic eye movements, i.e., an upward saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object.		hp.json		http://purl.obolibrary.org/obo/HP_0031833		
HP:0006866	biolink:PhenotypicFeature	Midline central nervous system lipomas		UMLS:C4024973	hp.json	Midline CNS lipomas	http://purl.obolibrary.org/obo/HP_0006866		
HP:0031838	biolink:PhenotypicFeature	Presence of xenobiotic	Presence of a chemical substance found within an individual that is not naturally produced or expected to be present in human tissues or bodily fluids.		hp.json		http://purl.obolibrary.org/obo/HP_0031838		
HP:0031840	biolink:PhenotypicFeature	Urine xenobiotic	The presence of a xenobiotic in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031840		
PATO:0000701	biolink:NamedThing	smooth	A texture quality inhering in a bearer by virtue of the bearer's processing a surface free of roughness or irregularities.		hp.json		http://purl.obolibrary.org/obo/PATO_0000701		value_slim|mpath_slim
PATO:0000700	biolink:NamedThing	rough	A texture quality inhering in a bearer by virtue of the bearer's irregular surface.		hp.json	coarse	http://purl.obolibrary.org/obo/PATO_0000700		value_slim|mpath_slim
PR:P10696	biolink:Protein	alkaline phosphatase, germ cell type (human)	An alkaline phosphatase, germ cell type that is encoded in the genome of human.	UniProtKB:P10696	hp.json	hALPG|alkaline phosphatase, placental-like (human)|alkaline phosphatase Nagao isozyme (human)|GCAP (human)|placental alkaline phosphatase-like (human)|ALPG|ALPPL2|ALPPL|ALP-1 (human)|PLAP-like (human)|germ cell alkaline phosphatase (human)	http://purl.obolibrary.org/obo/PR_P10696		
HP:0006834	biolink:PhenotypicFeature	Developmental stagnation at onset of seizures	A cessation of the development of a child in the areas of motor skills, speech and language, cognitive skills, and social and/or emotional skills, following the onset of epilepsy.	UMLS:C1836829	hp.json		http://purl.obolibrary.org/obo/HP_0006834		
HP:0031845	biolink:PhenotypicFeature	Abnormal libido	Any deviation from the normal sexual drive or desire for sexual activity.		hp.json		http://purl.obolibrary.org/obo/HP_0031845		
HP:0031846	biolink:PhenotypicFeature	Femur fracture	A break or crush injury of the thigh bone (femur).	MSH:D005264	hp.json	Femoral fracture	http://purl.obolibrary.org/obo/HP_0031846		
HP:0031847	biolink:PhenotypicFeature	Difficulty walking backward	Reduced ability to walk (ambulate) in a backwards direction.		hp.json		http://purl.obolibrary.org/obo/HP_0031847		
HP:0006837	biolink:PhenotypicFeature	Congenital Horner syndrome	A type of Horner syndrome with congenital onset.	MSH:C564178|UMLS:C1840475	hp.json		http://purl.obolibrary.org/obo/HP_0006837		
HP:0031848	biolink:PhenotypicFeature	Cock-walk gait	An abnormality of gait that can be observed in individuals with dystonic posture in which the individual walks with an extended trunk and flexed arms, while strutting on the toes without the heels touching the floor.		hp.json		http://purl.obolibrary.org/obo/HP_0031848		
GO:0032092	biolink:BiologicalProcess	positive regulation of protein binding	Any process that activates or increases the frequency, rate or extent of protein binding.		hp.json	up-regulation of protein binding|up regulation of protein binding|activation of protein binding|stimulation of protein binding|upregulation of protein binding	http://purl.obolibrary.org/obo/GO_0032092		
HP:0031841	biolink:PhenotypicFeature	Positive urine methadone test	Detection of methadone or its metabolite 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) in urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031841		
HP:0006830	biolink:PhenotypicFeature	obsolete Severe neonatal hypotonia in males			hp.json		http://purl.obolibrary.org/obo/HP_0006830		
GO:0032091	biolink:BiologicalProcess	negative regulation of protein binding	Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.		hp.json	inhibition of protein binding|downregulation of protein binding|down-regulation of protein binding|down regulation of protein binding	http://purl.obolibrary.org/obo/GO_0032091		
HP:0031842	biolink:PhenotypicFeature	Lymphangiectasis	Dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma.		hp.json	Lymphangiectasia	http://purl.obolibrary.org/obo/HP_0031842		
HP:0031843	biolink:PhenotypicFeature	Bradyphrenia	Abnormal slowness of thought processes.		hp.json	Slowness of thought|Slowed thoughts|Slowed thinking|Mental slowness	http://purl.obolibrary.org/obo/HP_0031843		
HP:0031844	biolink:PhenotypicFeature	Euphoria	A sense of intense joy or happiness that is beyond what would be expected under the given circumstances.		hp.json		http://purl.obolibrary.org/obo/HP_0031844		
PR:P22646	biolink:Protein	T-cell surface glycoprotein CD3 epsilon chain (mouse)	A CD3 epsilon that is encoded in the genome of mouse.	UniProtKB:P22646	hp.json	T-cell surface antigen T3/Leu-4 epsilon chain (mouse)|mCD3E|CD3e (mouse)|Cd3e	http://purl.obolibrary.org/obo/PR_P22646		
HP:0031849	biolink:PhenotypicFeature	Sleep-wake inversion	A reversal of sleeping habits with a tendency to sleep during the day and to be awake at night.		hp.json	Inverted sleep-wake cycle	http://purl.obolibrary.org/obo/HP_0031849		
GO:0032098	biolink:BiologicalProcess	regulation of appetite	Any process which modulates appetite, the desire or physical craving for food.		hp.json	regulation of hunger	http://purl.obolibrary.org/obo/GO_0032098		
UBERON:0014393	biolink:AnatomicalEntity	sweat of axilla	Sweat that is produced by the glands of the axilla.	FMA:63085	hp.json	axillary sweat	http://purl.obolibrary.org/obo/UBERON_0014393		
UBERON:0014394	biolink:AnatomicalEntity	uterine fat pad	Encapsulated adipose tissue associated with the uterus.	EMAPA:37979	hp.json	uterine fat depot|periuterine fat pad|peri-uterine fat pad	http://purl.obolibrary.org/obo/UBERON_0014394		pheno_slim
UBERON:0014395	biolink:AnatomicalEntity	proximal mesopodial bone	A proximal mesopodial endochondral element that is composed primarily of a bone tissue.		hp.json		http://purl.obolibrary.org/obo/UBERON_0014395		
UBERON:0014390	biolink:AnatomicalEntity	muscle layer of ileum	A muscular coat that is part of a ileum.	BTO:0005574|FMA:14958	hp.json	muscularis propria of ileum|ileal smooth muscle|smooth muscle of ileum|muscularis externa of ileum	http://purl.obolibrary.org/obo/UBERON_0014390		
UBERON:0014391	biolink:AnatomicalEntity	palmar/plantar sweat gland	A sweat gland that is part of the skin of the palmar part of the manus or plantar part of the pes.		hp.json	palmar/plantar eccrine sweat gland|sweat gland of palmar part of manus|sweat gland of palmar/plant part of autopod|palm/sole sweat gland|palmar eccrine sweat gland|palm sweat gland	http://purl.obolibrary.org/obo/UBERON_0014391		
UBERON:0014392	biolink:AnatomicalEntity	sweat of palm	Sweat that is produced by the glands on the palmar and plantar surfaces.	FMA:63084	hp.json	palmar sweat|palm sweat	http://purl.obolibrary.org/obo/UBERON_0014392		
HP:0031850	biolink:PhenotypicFeature	Abnormal hematocrit	Any deviation from the normal ratio of the volume of red blood cells to the total volume of blood.		hp.json	Abnormal Hct	http://purl.obolibrary.org/obo/HP_0031850		
HP:0031851	biolink:PhenotypicFeature	Reduced hematocrit	A reduction below the normal ratio of the volume of red blood cells to the total volume of blood.		hp.json	Low hematocrit|Reduced Hct	http://purl.obolibrary.org/obo/HP_0031851		
HP:0006849	biolink:PhenotypicFeature	Hypodysplasia of the corpus callosum	Developmental defect characterized by a small and malformed corpus callosum.	UMLS:C1850348	hp.json		http://purl.obolibrary.org/obo/HP_0006849		
UBERON:0014398	biolink:AnatomicalEntity	respiratory muscle	Muscle that is part of the respiratory system.	MESH:D012132	hp.json		http://purl.obolibrary.org/obo/UBERON_0014398		pheno_slim
UBERON:0014399	biolink:AnatomicalEntity	sinusoidal space	An anatomical space that is enclosed by a sinusoid.	FMA:63133	hp.json	lumen of sinusoid|sinusoid lumen	http://purl.obolibrary.org/obo/UBERON_0014399		
OBO:uberon/core#in_outermost_side_of	biolink:NamedThing	in_outermost_side_of			hp.json		http://purl.obolibrary.org/obo/uberon/core#in_outermost_side_of		
HP:0031856	biolink:PhenotypicFeature	Hobby horse gait	An abnormal gait characterized by toe walking, stiff legs, and skipping. The gait pattern has some resemblance to cock-walk gait, but affected individuals are able to improve their dystonic gait by walking backward.		hp.json		http://purl.obolibrary.org/obo/HP_0031856		
HP:0031857	biolink:PhenotypicFeature	Ineffective esophageal peristalsis	Reduced or inadequate esophageal peristalsis, with resultant slow passage of contents through the esophagus.		hp.json	Ineffective esophageal motility	http://purl.obolibrary.org/obo/HP_0031857		
HP:0006846	biolink:PhenotypicFeature	Acute encephalopathy		SNOMEDCT_US:2776000|UMLS:C1306587	hp.json		http://purl.obolibrary.org/obo/HP_0006846		
HP:0031858	biolink:PhenotypicFeature	Esophageal furrows	Longitudinal grooves in the surface of the esophagus arranged in a longitudinal fashion (from top to bottom of the esophagus).		hp.json		http://purl.obolibrary.org/obo/HP_0031858		
HP:0031853	biolink:PhenotypicFeature	Isomerism	Isomerism in the context of the congenitally malformed heart is defined as a situation where some paired structures on opposite sides of the left-right axis of the body are, in morphologic terms, symmetrical mirror images of each other.		hp.json		http://purl.obolibrary.org/obo/HP_0031853		
HP:0031854	biolink:PhenotypicFeature	Left Isomerism	A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal left-sided structures.		hp.json	Left-sided isomerism	http://purl.obolibrary.org/obo/HP_0031854		
HP:0031855	biolink:PhenotypicFeature	Right isomerism	A type of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal right-sided structures.		hp.json	Right-sided isomerism	http://purl.obolibrary.org/obo/HP_0031855		
HP:0006844	biolink:PhenotypicFeature	Absent patellar reflexes	Absence of the knee jerk reflex, which can normally be elicited by tapping the patellar tendon with a reflex hammer just below the patella.	UMLS:C0558844|SNOMEDCT_US:274817009	hp.json	Absent knee jerk reflex	http://purl.obolibrary.org/obo/HP_0006844		
HP:0004237	biolink:PhenotypicFeature	Large carpal bones	Increased size of carpal bones.	UMLS:C4021671	hp.json	Large wrist bones|Large carpals	http://purl.obolibrary.org/obo/HP_0004237		hposlim_core
HP:0004236	biolink:PhenotypicFeature	Irregular carpal bones	Carpal bones with irregular or fragmented margins.	UMLS:C4025401	hp.json	Irregular wrist bones	http://purl.obolibrary.org/obo/HP_0004236		
HP:0004235	biolink:PhenotypicFeature	Comma-shaped carpal bones		UMLS:C4025402	hp.json	Comma-shaped wrist bones	http://purl.obolibrary.org/obo/HP_0004235		
HP:0004234	biolink:PhenotypicFeature	Bone-in-a-bone appearance of carpal bones	The bone-in-bone sign is a radiographic finding produced by increased sclerosis (abnormally dense bone) occurring intermittently with zones of relatively normal bone density. This term should be used to describe such a finding in the carpal bones.	UMLS:C4025403	hp.json	Bone-in-a-bone appearance of wrist bones	http://purl.obolibrary.org/obo/HP_0004234		
HP:0006896	biolink:PhenotypicFeature	Hypnopompic hallucinations	Fleeting perceptual experiences that occur during the transition from sleep to wakefulness.	SNOMEDCT_US:69690008|UMLS:C0424082|MSH:D006212	hp.json		http://purl.obolibrary.org/obo/HP_0006896		
HP:0006897	biolink:PhenotypicFeature	Abducens palsy	Malfunction of the abducens nerve as manifested by impairment of the ability of the affected eye to be moved outward. Patients who develop abducens nerve palsy often present with binocular horizontal diplopia, which is a double vision when looking at objects side by side. There will be a notable weakness of the ipsilateral lateral rectus muscle leading to a deficit in of eye abduction on the affected side. Some patients may present with a constant head turning movement to maintain binocular fusion and to lessen the degree of diplopia.	SNOMEDCT_US:398963001|MSH:D020434|SNOMEDCT_US:398760006|UMLS:C0271355|MSH:C564661|SNOMEDCT_US:398925009	hp.json	Abducens nerve paresis|Lateral rectus muscle denervation paresis|Cranial nerve VI palsy|Sixth nerve palsy|Abducens nerve palsy|Abducens nerve paralysis	http://purl.obolibrary.org/obo/HP_0006897		
HP:0004239	biolink:PhenotypicFeature	Proximally placed carpal bones		UMLS:C4025399	hp.json		http://purl.obolibrary.org/obo/HP_0004239		
HP:0006899	biolink:PhenotypicFeature	Fusion of the cerebellar hemispheres		UMLS:C1866131	hp.json		http://purl.obolibrary.org/obo/HP_0006899		
HP:0004238	biolink:PhenotypicFeature	Lytic defects of carpal bones		UMLS:C4025400	hp.json		http://purl.obolibrary.org/obo/HP_0004238		
HP:0006892	biolink:PhenotypicFeature	Frontotemporal cerebral atrophy	Atrophy (wasting, decrease in size of cells or tissue) affecting the frontotemporal cerebrum.	UMLS:C4021584	hp.json	Cerebral atrophy, frontotemporal	http://purl.obolibrary.org/obo/HP_0006892		
HP:0006893	biolink:PhenotypicFeature	obsolete Severely dysplastic cerebellum			hp.json		http://purl.obolibrary.org/obo/HP_0006893		
HP:0006894	biolink:PhenotypicFeature	Hypoplastic olfactory lobes		UMLS:C1859231	hp.json		http://purl.obolibrary.org/obo/HP_0006894		
HP:0006895	biolink:PhenotypicFeature	Lower limb hypertonia		UMLS:C1845245	hp.json		http://purl.obolibrary.org/obo/HP_0006895		
HP:0004233	biolink:PhenotypicFeature	Advanced ossification of carpal bones	Ossification of carpal bones at an abnormally early age.	UMLS:C1849292|UMLS:C4280536	hp.json	Accelerated wrist bone maturation|Accelerated carpal bone maturation|Precociously ossified carpal bones|Advanced carpal bone age|Advanced carpal ossification	http://purl.obolibrary.org/obo/HP_0004233		
HP:0004232	biolink:PhenotypicFeature	Accessory carpal bones	The presence of more than the normal number of carpal bones.	SNOMEDCT_US:20136007|UMLS:C0265609|SNOMEDCT_US:9181003	hp.json	Supernumerary carpal bones|Extra wrist bones	http://purl.obolibrary.org/obo/HP_0004232		
HP:0004231	biolink:PhenotypicFeature	Carpal bone aplasia	Congenital absence of a carpal bone.	UMLS:C4280537|UMLS:C1836219	hp.json	Absent carpal bone|Absent carpal ossification center|Missing wrist bone|Absent carpal bones|Aplastic carpal bone|Absent wrist bone|Absent carpal ossification centre	http://purl.obolibrary.org/obo/HP_0004231		
GO:0019098	biolink:BiologicalProcess	reproductive behavior	The specific behavior of an organism that is associated with reproduction.		hp.json	multi-organism reproductive behavior|reproductive behavior in a multicellular organism|multicellular organism reproductive behavior|reproductive behaviour|single-organism reproductive behavior	http://purl.obolibrary.org/obo/GO_0019098		goslim_drosophila
HP:0004230	biolink:PhenotypicFeature	Subluxation of the proximal interphalangeal joint of the little finger	A partial dislocation of the proximal interphalangeal joint of the little finger.	UMLS:C4025404	hp.json	Partially dislocated innermost hinge joint of pinkie finger|Partially dislocated innermost hinge joint of little finger|Partially dislocated innermost hinge joint of pinky finger	http://purl.obolibrary.org/obo/HP_0004230		
HP:0006891	biolink:PhenotypicFeature	Thick cerebral cortex		UMLS:C4024970	hp.json		http://purl.obolibrary.org/obo/HP_0006891		
HP:0004248	biolink:PhenotypicFeature	Abnormality of the lunate bone		UMLS:C4025393	hp.json		http://purl.obolibrary.org/obo/HP_0004248		
HP:0004247	biolink:PhenotypicFeature	Small scaphoid	Underdevelopment of the scaphoid.	UMLS:C4025394	hp.json		http://purl.obolibrary.org/obo/HP_0004247		
HP:0004246	biolink:PhenotypicFeature	Delayed ossification of the scaphoid	Formation of bone tissue of scaphoid is less than expected for age.	UMLS:C4021670	hp.json	Delayed maturation of the scaphoid	http://purl.obolibrary.org/obo/HP_0004246		
GO:0032060	biolink:BiologicalProcess	bleb assembly	The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.		hp.json	membrane blebbing|plasma membrane blebbing|cell blebbing|plasma membrane bleb assembly|blebbing	http://purl.obolibrary.org/obo/GO_0032060		
HP:0004245	biolink:PhenotypicFeature	Comma-shaped scaphoid		UMLS:C4025395	hp.json		http://purl.obolibrary.org/obo/HP_0004245		
UBERON:0026386	biolink:AnatomicalEntity	lumbar spinal cord white matter		BIRNLEX:1639	hp.json	lumbar spinal cord white matter|lumbar spinal cord white matter	http://purl.obolibrary.org/obo/UBERON_0026386		
HP:0004249	biolink:PhenotypicFeature	Accessory lunate		UMLS:C4025392	hp.json		http://purl.obolibrary.org/obo/HP_0004249		
HP:0004240	biolink:PhenotypicFeature	Sclerotic foci within carpal bones		UMLS:C4025398|UMLS:C4280535	hp.json	Hardened spots within wrist bones|Stiffened spots within wrist bones	http://purl.obolibrary.org/obo/HP_0004240		
HP:0004244	biolink:PhenotypicFeature	Accessory scaphoid		UMLS:C4025396	hp.json		http://purl.obolibrary.org/obo/HP_0004244		
HP:0004243	biolink:PhenotypicFeature	Abnormality of the scaphoid		UMLS:C4025397	hp.json		http://purl.obolibrary.org/obo/HP_0004243		
CHEBI:3992	biolink:ChemicalSubstance	cyclic ketone		KEGG:C02019	hp.json	cyclic ketones|Cyclic ketone	http://purl.obolibrary.org/obo/CHEBI_3992		3_STAR
HP:0004242	biolink:PhenotypicFeature	Broad carpal bones		UMLS:C3554618	hp.json	Wide carpal bones|Wide wrist bones	http://purl.obolibrary.org/obo/HP_0004242		
HP:0004241	biolink:PhenotypicFeature	Stippled calcification in carpal bones	Point-shaped (punctate) calcifications affecting the carpal bones.	UMLS:C1844846	hp.json	Punctate calcifications of carpals	http://purl.obolibrary.org/obo/HP_0004241		
GO:0007097	biolink:BiologicalProcess	nuclear migration	The directed movement of the nucleus to a specific location within a cell.		hp.json	positioning of nucleus|establishment of nucleus localization|establishment of position of nucleus|nucleus migration|establishment of cell nucleus localization|nuclear positioning|establishment of localization of nucleus|nucleus positioning|nuclear movement|establishment of nucleus localisation	http://purl.obolibrary.org/obo/GO_0007097		goslim_aspergillus
HP:0031801	biolink:PhenotypicFeature	Vocal cord dysfunction	Any functional anomaly of the vocal cord.		hp.json		http://purl.obolibrary.org/obo/HP_0031801		
HP:0004214	biolink:PhenotypicFeature	Curved phalanges of the 5th finger	Curved phalanges of the 5th (little) finger.	UMLS:C4025407	hp.json	Curved pinky finger bone|Curved little finger bone|Curved pinkie finger bone	http://purl.obolibrary.org/obo/HP_0004214		
HP:0006879	biolink:PhenotypicFeature	Pontocerebellar atrophy	Atrophy affecting the pons and the cerebellum.	UMLS:C1853766	hp.json	Cerebellopontine atrophy	http://purl.obolibrary.org/obo/HP_0006879		
HP:0031803	biolink:PhenotypicFeature	Fundus hemorrhage	Bleeding within the fundus of the eye.		hp.json	Fundus haemorrhage	http://purl.obolibrary.org/obo/HP_0031803		
HP:0004213	biolink:PhenotypicFeature	Abnormal 5th finger phalanx morphology	Abnormality of the phalanges of the 5th (little) finger.	UMLS:C4025408	hp.json	Abnormality of the pinky finger bone|Abnormality of the little finger bone|Abnormality of the pinkie finger bone|Abnormality of the phalanges of the 5th finger	http://purl.obolibrary.org/obo/HP_0004213		
HP:0031804	biolink:PhenotypicFeature	Premacular hemorrhage			hp.json	Premacular haemorrhage	http://purl.obolibrary.org/obo/HP_0031804		
HP:0004219	biolink:PhenotypicFeature	Abnormality of the middle phalanx of the 5th finger		UMLS:C4025406	hp.json	Abnormality of the middle bone of pinky finger|Abnormality of the middle bone of pinkie finger|Abnormality of the middle bone of little finger	http://purl.obolibrary.org/obo/HP_0004219		
HP:0004218	biolink:PhenotypicFeature	Symphalangism of the 5th finger	Fusion of two or more bones of the 5th finger.	UMLS:C4021676	hp.json	Fused little finger bones|Fused pinky finger bones|Symphalagism of the little finger|Fifth finger symphalangism|Fused pinkie finger bones	http://purl.obolibrary.org/obo/HP_0004218		
HP:0031800	biolink:PhenotypicFeature	Elevated circulating apolipoprotein A-II concentration	An increased concentration in blood of apolipoprotein A-II, a major component of HDL particles, associated with triglyceride and glucose metabolism.		hp.json	Elevated APOAII level|Elevated apoA-II level|Elevated apolipoprotein A-II level|Elevated Apo-AII level	http://purl.obolibrary.org/obo/HP_0031800		
HP:0004216	biolink:PhenotypicFeature	Osteolytic defects of the phalanges of the 5th finger	Dissolution or degeneration of bone tissue of the phalanges of the 5th finger.	UMLS:C4021677	hp.json	Lytic defects of the phalanges of the little finger	http://purl.obolibrary.org/obo/HP_0004216		
HP:0006877	biolink:PhenotypicFeature	obsolete Mental retardation, in some			hp.json		http://purl.obolibrary.org/obo/HP_0006877		
HP:0006870	biolink:PhenotypicFeature	Lobar holoprosencephaly	A type of holoprosencephaly in which most of the right and left cerebral hemispheres and lateral ventricles are separated but the most rostral aspect of the telencephalon, the frontal lobes, are fused, especially ventrally.	MSH:D016142|UMLS:C0431362|SNOMEDCT_US:253136007	hp.json		http://purl.obolibrary.org/obo/HP_0006870		
HP:0031809	biolink:PhenotypicFeature	Archibald's sign	Shortening of the fourth and fifth metacarpals when the fist is clenched.		hp.json	Archibald's metacarpal sign|Knuckle dimple	http://purl.obolibrary.org/obo/HP_0031809		
GO:0032059	biolink:CellularComponent	bleb	A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.	Wikipedia:Bleb_(cell_biology)	hp.json	plasma membrane bleb	http://purl.obolibrary.org/obo/GO_0032059		goslim_pir
GO:0032058	biolink:BiologicalProcess	positive regulation of translational initiation in response to stress	Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.		hp.json	upregulation of translation initiation in response to stress|stimulation of translation initiation in response to stress|up regulation of translation initiation in response to stress|up-regulation of translation initiation in response to stress|activation of translation initiation in response to stress	http://purl.obolibrary.org/obo/GO_0032058		
HP:0006872	biolink:PhenotypicFeature	Cerebral hypoplasia	Underdevelopment of the cerebrum.	UMLS:C1855330	hp.json	Underdeveloped cerebrum|Small cerebrum	http://purl.obolibrary.org/obo/HP_0006872		
GO:0032057	biolink:BiologicalProcess	negative regulation of translational initiation in response to stress	Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.		hp.json	inhibition of translation initiation in response to stress|down-regulation of translation initiation in response to stress|downregulation of translation initiation in response to stress|down regulation of translation initiation in response to stress	http://purl.obolibrary.org/obo/GO_0032057		
HP:0006873	biolink:PhenotypicFeature	Symmetrical progressive peripheral demyelination	A symmetric and progressive loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.	UMLS:C4024972	hp.json		http://purl.obolibrary.org/obo/HP_0006873		
HP:0031805	biolink:PhenotypicFeature	Intraretinal hemorrhage	A subtype of fundus hemorrhage occurring within the neurosensory retina. Intraretinal haemorrhages may be 'dot' or' blot' shaped or flame shaped depending upon their depth within the retina.		hp.json	Intraretinal haemorrhage	http://purl.obolibrary.org/obo/HP_0031805		
HP:0031806	biolink:PhenotypicFeature	Abnormal basophil count	Any deviation from the normal number of basophils per volume in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031806		
HP:0031807	biolink:PhenotypicFeature	Increased basophil count	An abnormally increased count of basophils per volume in the blood circulation.		hp.json	Basophilia	http://purl.obolibrary.org/obo/HP_0031807		
HP:0031808	biolink:PhenotypicFeature	Decreased basophil count	An abnormally reduced count of basophils per volume in the blood circulation.		hp.json		http://purl.obolibrary.org/obo/HP_0031808		
HP:0004226	biolink:PhenotypicFeature	Curved distal phalanx of the 5th finger	Curved appearance of the distal phalanx of the 5th (little) finger.	UMLS:C4021672	hp.json	Curved terminal phalanx of the little finger|Curved outermost pinky finger bone|Curved outermost little finger bone|Curved outermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0004226		
HP:0006889	biolink:PhenotypicFeature	Intellectual disability, borderline	Borderline intellectual disability is defined as an intelligence quotient (IQ) in the range of 70-85.	SNOMEDCT_US:77287004|UMLS:C0006009	hp.json	Intellectual disability, borderline|Mental retardation, borderline	http://purl.obolibrary.org/obo/HP_0006889		
HP:0031812	biolink:PhenotypicFeature	Nitrituria	Presence of nitrites in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031812		
HP:0004225	biolink:PhenotypicFeature	Abnormality of the distal phalanx of the 5th finger	Abnormality of the distal phalanx of the 5th (little) finger.	UMLS:C4021673	hp.json	Abnormality of the outermost little finger bone|Abnormality of the terminal phalanx of the little finger|Abnormality of the outermost pinky finger bone|Abnormality of the outermost pinkie finger bone|Abnormality of the distal phalanx of the little finger	http://purl.obolibrary.org/obo/HP_0004225		
HP:0031813	biolink:PhenotypicFeature	Colonic eosinophilia	An excess of eosinophilic cells in colonic tissue, i.e., eosinophilic infiltration in the colon.		hp.json	Eosinophilic infiltration in the colon|Eosinophilic colitis	http://purl.obolibrary.org/obo/HP_0031813		
HP:0004224	biolink:PhenotypicFeature	Abnormality of the epiphysis of the middle phalanx of the 5th finger	Abnormality of the epiphysis of the middle phalanx of the fifth finger. This epiphysis is located on the proximal end of the phalanx.	UMLS:C4025405	hp.json	Abnormality of the end part of middle little finger bone|Abnormality of the end part of middle pinkie finger bone|Abnormality of the end part of middle pinky finger bone	http://purl.obolibrary.org/obo/HP_0004224		
HP:0031814	biolink:PhenotypicFeature	Palilalia	Repetition of one's own words or phrases.		hp.json		http://purl.obolibrary.org/obo/HP_0031814		
HP:0004223	biolink:PhenotypicFeature	Ivory epiphysis of the distal phalanx of the 5th finger	Sclerosis of the epiphysis of the distal phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.	UMLS:C4021674	hp.json	Ivory epiphysis of the distal phalanx of the little finger|Increased bone density of end part of the outermost pinky finger bone|Increased bone density of end part of the outermost little finger bone|Increased bone density of end part of the outermost pinkie finger bone|Ivory epiphysis of the terminal phalanx of the little finger	http://purl.obolibrary.org/obo/HP_0004223		
HP:0031815	biolink:PhenotypicFeature	Abnormal oral physiology	A functional anomaly of the mouth (which is also known as the oral cavity).		hp.json		http://purl.obolibrary.org/obo/HP_0031815		
HP:0006886	biolink:PhenotypicFeature	Impaired distal vibration sensation	A decrease in the ability to perceive vibration in the distal portions of the limbs.	UMLS:C1853767	hp.json	Decreased distal vibration sense	http://purl.obolibrary.org/obo/HP_0006886		
HP:0006887	biolink:PhenotypicFeature	Intellectual disability, progressive	The term progressive intellectual disability should be used if intelligence decreases/deteriorates over time.	UMLS:C1846149	hp.json	Progressive mental retardation|Mental retardation, progressive|Intellectual disability, progressive	http://purl.obolibrary.org/obo/HP_0006887		
HP:0031810	biolink:PhenotypicFeature	Anti-ganglioside antibody positivity	The presence of autoantibodies (immunoglobulins) in the serum that react to gangliosides.		hp.json		http://purl.obolibrary.org/obo/HP_0031810		
HP:0004227	biolink:PhenotypicFeature	Short distal phalanx of the 5th finger	Hypoplastic/small distal phalanx of the fifth finger.	UMLS:C1836674	hp.json	Short outermost pinkie finger bone|Fifth digit distal phalangeal hypoplasia|Brachytelophalangism V|Short distal phalanx of the fifth finger|Short outermost pinky finger bone|Short outermost little finger bone|Hypoplastic/small terminal phalanx of the little finger	http://purl.obolibrary.org/obo/HP_0004227		
HP:0031811	biolink:PhenotypicFeature	Bilirubinuria	Presence of conjugated bilirubin in the urine.		hp.json		http://purl.obolibrary.org/obo/HP_0031811		
HP:0006888	biolink:PhenotypicFeature	Meningoencephalocele		SNOMEDCT_US:52330001|UMLS:C0266456	hp.json		http://purl.obolibrary.org/obo/HP_0006888		
HP:0006881	biolink:PhenotypicFeature	Diffuse peripheral demyelination	A diffuse loss of myelin from the internode regions along myelinated nerve fibers of the peripheral nervous system.	UMLS:C4024971	hp.json		http://purl.obolibrary.org/obo/HP_0006881		
HP:0006882	biolink:PhenotypicFeature	Severe hydrocephalus		UMLS:C3278123	hp.json		http://purl.obolibrary.org/obo/HP_0006882		
HP:0004222	biolink:PhenotypicFeature	Cone-shaped epiphysis of the distal phalanx of the 5th finger	A cone-shaped appearance of the epiphysis of the distal phalanx of the little finger of the hand, producing a 'ball-in-a-socket' appearance. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of the phalanx.	UMLS:C4021675	hp.json	Cone-shaped epiphysis of the distal phalanx of the little finger|Cone-shaped end part of the outermost pinky finger bone|Cone-shaped end part of the outermost little finger bone|Cone-shaped end part of the outermost pinkie finger bone	http://purl.obolibrary.org/obo/HP_0004222		
HP:0031816	biolink:PhenotypicFeature	Abnormal oral morphology	Any structural anomaly of the mouth, which is also known as the oral cavity.		hp.json		http://purl.obolibrary.org/obo/HP_0031816		
HP:0031817	biolink:PhenotypicFeature	Decreased circulating parathyroid hormone level	An abnormally decreased concentration of parathyroid hormone.		hp.json	Decreased serum parathyroid hormone level|Decreased serum PTH|Decreased serum parathyroid hormone|Decreased circulating PTH level	http://purl.obolibrary.org/obo/HP_0031817		
HP:0031818	biolink:PhenotypicFeature	Abnormal waist to hip ratio	A deviation from normal of the waist to hip ratio, defined as the waist measurement divided by hip measurement.		hp.json		http://purl.obolibrary.org/obo/HP_0031818		
HP:0004220	biolink:PhenotypicFeature	Short middle phalanx of the 5th finger	Hypoplastic/small middle phalanx of the fifth finger.	UMLS:C1834060	hp.json	Brachymesophalangy V (finger)|Short middle bone of the little finger|Brachymesophalangism V|Hypoplastic/small middle phalanx of the little finger|Hypoplastic middle phalanx of the 5th finger|Short middle bone of the pinky finger|5th finger middle phalangeal hypoplasia|Fifth finger mid-phalanx hypoplasia|Type A3 brachydactyly|Short middle bone of the pinkie finger|Hypoplastic/small middle phalanx of the 5th finger|Hypoplastic fifth finger middle phalanx|Short middle phalanx of the little finger	http://purl.obolibrary.org/obo/HP_0004220		
HP:0031819	biolink:PhenotypicFeature	Increased waist to hip ratio	Increased waist-to-hip ratio (WHR) is a measurement above the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement.		hp.json	Increased WHR|Increased waist-to-hip ratio|Increased waist-hip ratio	http://purl.obolibrary.org/obo/HP_0031819		
HP:0006880	biolink:PhenotypicFeature	Cerebellar hemangioblastoma	A hemangioblastoma of the cerebellum.	UMLS:C1332900|NCIT:C3801	hp.json	Hemangioblastoma, sporadic cerebellar	http://purl.obolibrary.org/obo/HP_0006880		
GO:0032042	biolink:BiologicalProcess	mitochondrial DNA metabolic process	The chemical reactions and pathways involving mitochondrial DNA.		hp.json	mtDNA metabolism|mitochondrial DNA metabolism|mtDNA metabolic process	http://purl.obolibrary.org/obo/GO_0032042		
GO:0046681	biolink:BiologicalProcess	response to carbamate	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbamate stimulus. Carbamates are a group of insecticides and parasiticides that act by inhibiting cholinesterase.		hp.json	carbamate resistance|carbamate susceptibility/resistance	http://purl.obolibrary.org/obo/GO_0046681		
CL:2000032	biolink:Cell	peripheral nervous system neuron	Any neuron that is part of a peripheral nervous system.		hp.json		http://purl.obolibrary.org/obo/CL_2000032		
UBERON:0002360	biolink:AnatomicalEntity	meninx	Membrane organ that surrounds the brain and the spinal cord.	EV:0100312|TAO:0001355|MAT:0000113|UMLS:C0025285|MESH:D008578|BTO:0000144|EMAPA:32660|Wikipedia:Meninx|GAID:687|NLXANAT:090204|OpenCyc:Mx4rwDOl8JwpEbGdrcN5Y29ycA|CALOHA:TS-1177|FMA:9589|EFO:0000867|ZFA:0001355|NCIT:C12348|VHOG:0001295|MA:0001113	hp.json	meninx primitiva|meningeal layer|layer of meninges	http://purl.obolibrary.org/obo/UBERON_0002360		organ_slim|pheno_slim|efo_slim|uberon_slim|vertebrate_core
CHEBI:59740	biolink:ChemicalSubstance	nucleophilic reagent	A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons.		hp.json	nucleophiles|nucleophilic reagents|nucleophile	http://purl.obolibrary.org/obo/CHEBI_59740		3_STAR
UBERON:0002362	biolink:AnatomicalEntity	arachnoid mater	A think avascular meningeal layer, between the pia mater and the dural mater. It is separated from the pia mater by the subarachnoid space.	BTO:0001636|CALOHA:TS-0052|UMLS:C1510935|EMAPA:32659|MESH:D001099|FMA:9591|NLXANAT:090208|OpenCyc:Mx4rve5HlJwpEbGdrcN5Y29ycA|GAID:688|MA:0001114|NCIT:C32136|EV:0100314	hp.json	arachnoidea mater|arachnoid mater of neuraxis|arachnoid membrane|arachnoid	http://purl.obolibrary.org/obo/UBERON_0002362		pheno_slim|uberon_slim
UBERON:0002361	biolink:AnatomicalEntity	pia mater	The innermost layer of the leptomeninges, consisting of a delicate membrane closely covering the surface of the brain and spinal cord,and lying under the arachnoid membrane. The pia, unlike the arachnoid, extends into the sulci in gyrencephalic animals.	GAID:693|EHDAA:2685|BTO:0001635|NCIT:C33321|EHDAA:2001|EHDAA:6566|EHDAA:2099|OpenCyc:Mx4rvtesBZwpEbGdrcN5Y29ycA|EHDAA:3692|EMAPA:32663|UMLS:C0031869|NLXANAT:090209|EHDAA:6583|FMA:9590|EHDAA:2867|EHDAA:2833|MA:0001116|RETIRED_EHDAA2:0001464|EV:0100315|MESH:D010841|EHDAA2:0004318|EHDAA:1367|EHDAA:3710|EHDAA:1961	hp.json	pial membrane|pia mater of neuraxis|pia	http://purl.obolibrary.org/obo/UBERON_0002361		pheno_slim|uberon_slim
UBERON:0002368	biolink:AnatomicalEntity	endocrine gland	Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified].	Wikipedia:Endocrine_gland|MESH:D004702|UMLS:C0014133|MA:0002563|SCTID:40818001|EMAPA:35999|BTO:0001488|OpenCyc:Mx4rvbkiRZwpEbGdrcN5Y29ycA|EHDAA2:0003098|NCIT:C12704|CALOHA:TS-1300|AEO:0000098|GAID:335|FMA:9602	hp.json	ductless gland|glandulae endocrinae|ductless gland|ductless gland|glandulae endocrinae|glandula endocrina	http://purl.obolibrary.org/obo/UBERON_0002368		organ_slim|pheno_slim|uberon_slim
UBERON:0002367	biolink:AnatomicalEntity	prostate gland	The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.	UMLS:C0033572|FMA:9600|CALOHA:TS-0828|MESH:D011467|VHOG:0001261|EV:0100104|BTO:0001129|EMAPA:19287|NCIT:C12410|OpenCyc:Mx4rv6trqZwpEbGdrcN5Y29ycA|GAID:392|MAT:0000078|MIAA:0000078|MA:0000404|galen:ProstateGland|EFO:0000858	hp.json	male prostate|prostata|prostate	http://purl.obolibrary.org/obo/UBERON_0002367		major_organ|organ_slim|pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0002369	biolink:AnatomicalEntity	adrenal gland	Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO].	UMLS:C0001625|OpenCyc:Mx4rvXYiz5wpEbGdrcN5Y29ycA|galen:AdrenalGland|VHOG:0001141|NCIT:C12666|MIAA:0000071|XAO:0000164|EFO:0000238|MESH:D000311|EV:0100135|AAO:0010551|BTO:0000047|CALOHA:TS-0016|GAID:446|EMAPA:18426|FMA:9604|MA:0000116|MAT:0000071	hp.json	epinephros|glandula suprarenalis|suprarenal capsule|suprarenal gland|adrenal|glandula adrenalis|adrenal capsule|atrabiliary capsule|interrenal gland|epinephric gland|glandula suprarenalis|adrenal medulla cell	http://purl.obolibrary.org/obo/UBERON_0002369		organ_slim|pheno_slim|uberon_slim
UBERON:0002364	biolink:AnatomicalEntity	tympanic membrane	A thin membrane that separates the external ear from the middle ear, consisting of two epithelia (one part of the the external accoustic meatus epithelium, the other part of the tympanic cavity epithelium) with a fibrous layer between them. Its function is to transmit sound from the air to the ossicles inside the middle ear. The malleus bone bridges the gap between the eardrum and the other ossicles. Rupture or perforation of the eardrum can lead to conductive hearing loss. [WP,unvetted].	GAID:870|EV:0100358|FMA:9595|MESH:D014432|EMAPA:19062|VHOG:0001146|UMLS:C0041445|XAO:0000212|MA:0000257|NCIT:C12502	hp.json	Rivinus' membrane|myrinx|eardrum|paries membranaceus cavi tympani|lateral wall of tympanic cavity|tympanum|ear drum|membranous wall of tympanic cavity	http://purl.obolibrary.org/obo/UBERON_0002364		organ_slim|pheno_slim|uberon_slim
UBERON:0002363	biolink:AnatomicalEntity	dura mater	Thick, fibrous meningeal covering surrounding the brain and spinal cord. It is the outermost of the three meningeal coverings. It consists of two layers: the periosteal dura linking the inner surface of the skull and the meningeal dura that lies above the arachnoid dural membrane. The meningeal layer draws away from the periosteal layer and certain locations to form the dural reflections.	NCIT:C32488|BTO:0001637|EV:0100313|UMLS:C0013313|GAID:691|OpenCyc:Mx4rvvmzqZwpEbGdrcN5Y29ycA|SCTID:362301008|MESH:D004388|EMAPA:32664|FMA:9592|CALOHA:TS-2008|Wikipedia:Dura_mater|NLXANAT:090206|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1462|MA:0001115	hp.json	dura mater of neuraxis|dura|pachymeninges	http://purl.obolibrary.org/obo/UBERON_0002363		organ_slim|pheno_slim|uberon_slim
UBERON:0002365	biolink:AnatomicalEntity	exocrine gland	A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas.	CALOHA:TS-2012|Wikipedia:Exocrine_gland|MA:0002564|BTO:0000765|FMA:9596|GAID:34|EMAPA:35327|SCTID:115976003|UMLS:C0015282|MESH:D005088|EHDAA2:0003097|AEO:0000097|NCIT:C12712	hp.json	glandula exocrina|ducted gland|glandula exocrina	http://purl.obolibrary.org/obo/UBERON_0002365		organ_slim|pheno_slim|uberon_slim
UBERON:0002349	biolink:AnatomicalEntity	myocardium	The middle layer of the heart, comprised mainly of striated cardiac muscle fibers.	TAO:0001319|Wikipedia:Myocardium|EHDAA2:0004150|CALOHA:TS-0440|BTO:0000901|galen:Myocardium|OpenCyc:Mx4ro36AFrCvEduAAAAOpmP6tw|UMLS:C0027061|RETIRED_EHDAA2:0001220|VHOG:0000083|XAO:0000065|MA:0000164|AAO:0010410|MAT:0000453|GAID:173|FMA:9462|BSA:0000089|EMAPA:32688|MESH:D009206|EV:0100022|ZFA:0001319|SCTID:362012001|EFO:0000819|NCIT:C12371	hp.json	heart muscle|heart muscle|cardiac muscle|heart myocardium|muscle of heart	http://purl.obolibrary.org/obo/UBERON_0002349		uberon_slim|vertebrate_core|pheno_slim|efo_slim
CL:2000022	biolink:Cell	cardiac septum cell	Any native cell that is part of a cardiac septum.		hp.json		http://purl.obolibrary.org/obo/CL_2000022		
CL:2000025	biolink:Cell	spinal cord oligodendrocyte	Any oligodendrocyte that is part of a spinal cord.		hp.json		http://purl.obolibrary.org/obo/CL_2000025		
CL:2000020	biolink:Cell	inner cell mass cell	Any native cell that is part of a inner cell mass.		hp.json		http://purl.obolibrary.org/obo/CL_2000020		
UBERON:0002351	biolink:AnatomicalEntity	sinoatrial node	The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA].	NCIT:C33555|GAID:561|FMA:9477|ZFA:0005069|SCTID:277687007|MA:0000097|OpenCyc:Mx4rOhejDGMcEd2AAABQjYGu0g|UMLS:C0037189|TAO:0005069|BTO:0004358|MESH:D012849|Wikipedia:Sinoatrial_node|EHDAA2:0004184|EMAPA:35772	hp.json	sinoatrial node|sinuatrial nodal muscle tissue|SA node|SA nodal muscle tissue|nodus sinuatrialis|sinuatrial node|nodus sinuatrialis|node of Keith-Flack|sinu-atrial node|Koch's node|cardiac pacemaker|sinus node|sinus node of Keith and Flack	http://purl.obolibrary.org/obo/UBERON_0002351		pheno_slim|uberon_slim|vertebrate_core
CHEBI:35786	biolink:ChemicalSubstance	phosphosphingolipid			hp.json		http://purl.obolibrary.org/obo/CHEBI_35786		
UBERON:0002350	biolink:AnatomicalEntity	conducting system of heart	The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO].	VHOG:0001271|SCTID:281489000|MESH:D006329|FMA:9476|EV:0100025|EMAPA:35428|MA:0000094|ZFA:0005063|EFO:0003909|EHDAA2:0004185|TAO:0005063	hp.json	complexus stimulans cordis|systema conducente cordis|heart conduction system|cardiac impulse conducting system|central conduction system|cardiac conduction system|impulse conducting system|cardiac conducting system|cardionector	http://purl.obolibrary.org/obo/UBERON_0002350		pheno_slim|efo_slim|vertebrate_core
CHEBI:35788	biolink:ChemicalSubstance	seco-steroid			hp.json	seco-steroids	http://purl.obolibrary.org/obo/CHEBI_35788		3_STAR
CL:2000029	biolink:Cell	central nervous system neuron	Any neuron that is part of a central nervous system.		hp.json		http://purl.obolibrary.org/obo/CL_2000029		
CHEBI:35789	biolink:ChemicalSubstance	oxo steroid			hp.json	ketosteroids|keto steroids|oxo steroids|oxosteroids	http://purl.obolibrary.org/obo/CHEBI_35789		3_STAR
UBERON:0002357	biolink:AnatomicalEntity	serous pericardium	Serous membrane which is divided into parietal and visceral serous pericardium.	SCTID:243954002|Wikipedia:Serous_pericardium|FMA:9582|EMAPA:19030|MA:0002739	hp.json	pericardium serosum|pericardium serosum|serous portion of pericardium	http://purl.obolibrary.org/obo/UBERON_0002357		uberon_slim
UBERON:0002356	biolink:AnatomicalEntity	perineum	Subdivision of trunk proper, which is demarcated from the pelvis by the inferior surface of the pelvic diaphragm and from the lower limbs by the perineofemoral lines; together with the thorax, abdomen, and pelvis, it constitutes the trunk[FMA].	MESH:D010502|EFO:0004141|FMA:9579|MA:0002466|GAID:90|NCIT:C33301|UMLS:C0031066|galen:Perineum|EMAPA:36628|EV:0100013|EHDAA2:0004015|OpenCyc:Mx4rvcHSh5wpEbGdrcN5Y29ycA	hp.json	regio perinealis|perineal region	http://purl.obolibrary.org/obo/UBERON_0002356		pheno_slim|efo_slim|uberon_slim
UBERON:0002359	biolink:AnatomicalEntity	fibrous pericardium	Membrane organ which is attached to the pericardial sac proper and the central tendon of diaphragm and is continuous with the pretracheal fascia.[FMA].	EMAPA:19029|Wikipedia:Fibrous_pericardium|FMA:9586|SCTID:243953008|MA:0002738	hp.json	pericardium fibrosum|pericardium fibrosum|fibrous portion of pericardium	http://purl.obolibrary.org/obo/UBERON_0002359		uberon_slim|organ_slim
UBERON:0002358	biolink:AnatomicalEntity	peritoneum	A serous membrane that lines the peritoneal cavity[VHOG,modified].	UMLS:C0031153|GAID:18|OpenCyc:Mx4rvjJ72ZwpEbGdrcN5Y29ycA|Wikipedia:Peritoneum|FMA:9584|CALOHA:TS-2072|NCIT:C12770|EV:0100087|ZFA:0005120|galen:Peritoneum|MA:0000449|VHOG:0001257|XAO:0000139|TAO:0005120|MESH:D010537|BTO:0001472|AAO:0010814	hp.json	peritonaeum	http://purl.obolibrary.org/obo/UBERON_0002358		uberon_slim|vertebrate_core|pheno_slim
CHEBI:35780	biolink:ChemicalSubstance	phosphate ion	A phosphorus oxoanion that is the conjugate base of phosphoric acid.		hp.json	phosphate|phosphate ions|Pi	http://purl.obolibrary.org/obo/CHEBI_35780		3_STAR
UBERON:0002352	biolink:AnatomicalEntity	atrioventricular node	An area of conducting tissue between the atria and the ventricles of the heart that conducts the normal electrical impulse from the atria to the ventricles.	EMAPA:35153|TAO:0005070|FMA:9478|MAT:0000498|UMLS:C0004247|MA:0000095|EFO:0000276|BTO:0005689|Wikipedia:Atrioventricular_node|NCIT:C32161|MESH:D001283|SCTID:277688002|GAID:558|OpenCyc:Mx4rMfD91mMcEd2AAABQjYGu0g|VHOG:0001474|ZFA:0005070|EHDAA2:0004183	hp.json	atriovetricular node|AV node|AV nodal muscle tissue|nodus atrioventricularis|Aschoff-Tawara node|atrio-ventricular node|A-V node|node of Tawara|atrioventricular nodal muscle tissue|downstream pacemaker|nodus atrioventricularis|nodus atrioventricularis	http://purl.obolibrary.org/obo/UBERON_0002352		vertebrate_core|pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0002355	biolink:AnatomicalEntity	pelvic region of trunk	The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs.	EFO:0002805|NCIT:C12767|FMA:9578|SCTID:229765004|Wikipedia:Pelvis|MESH:D010388|MESH:A01.673|galen:Pelvis|BTO:0001006|MA:0000030|EV:0100012|OpenCyc:Mx4rvVjiTJwpEbGdrcN5Y29ycA|EMAPA:35931|GAID:87|UMLS:C0030797|CALOHA:TS-2227	hp.json	true pelvis|pelvis region|pelvic region|pelvis|lesser pelvis	http://purl.obolibrary.org/obo/UBERON_0002355		pheno_slim|efo_slim|uberon_slim
CHEBI:35782	biolink:ChemicalSubstance	diphosphate ion			hp.json	diphosphate ions|PPi	http://purl.obolibrary.org/obo/CHEBI_35782		3_STAR
UBERON:0002354	biolink:AnatomicalEntity	cardiac Purkinje fiber	The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.	Wikipedia:Purkinje_fiber|EMAPA:35718|BTO:0001735|GAID:560|UMLS:C0034144|NCIT:C33430|MA:0000096|FMA:9492|MESH:D011690	hp.json	cardiac Purkinje fiber|heart Purkinje fiber|subendocardial branch|Purkinje fiber|myofibra conducens cardiacus	http://purl.obolibrary.org/obo/UBERON_0002354		pheno_slim|uberon_slim
GO:0044042	biolink:NamedThing	glucan metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0044042		
UBERON:0002338	biolink:AnatomicalEntity	lamina propria of bronchus	A lamina propria that is part of a bronchus [Automatically generated definition].	MA:0001836|FMA:86619|EMAPA:35194|UMLS:C1707054|NCIT:C49212	hp.json	lamina propria mucosa of bronchial trunk|lamina propria mucosa of bronchus|lamina propria of bronchi|lamina propria of bronchial trunk|lamina propria mucosae of bronchi|lamina propria mucosae of bronchial trunk|bronchial lamina propria|bronchus lamina propria mucosae|bronchi lamina propria mucosa|bronchial trunk lamina propria mucosa|bronchial trunk lamina propria mucosae|bronchi lamina propria mucosae|bronchus lamina propria mucosa|lamina propria mucosae of bronchus|bronchus lamina propria|bronchial trunk lamina propria|bronchi lamina propria|lamina propria mucosa of bronchi	http://purl.obolibrary.org/obo/UBERON_0002338		
CHEBI:35753	biolink:ChemicalSubstance	tricarboxylic acid anion	Any anion of a tricarboxylic acid  formed by deprotonation of at least one carboxy group.		hp.json	tricarboxylic acid anion|tricarboxylic acid anions	http://purl.obolibrary.org/obo/CHEBI_35753		3_STAR
CHEBI:35757	biolink:ChemicalSubstance	monocarboxylic acid anion	A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated.	KEGG:C00060	hp.json	Carboxylate|monocarboxylates|Monocarboxylate|a monocarboxylate|monocarboxylic acid anions	http://purl.obolibrary.org/obo/CHEBI_35757		3_STAR
UBERON:0002346	biolink:AnatomicalEntity	neurectoderm	Embryonic ectoderm that gives rise to nervous tissue.	CALOHA:TS-1212|NCIT:C34228|FBbt:00001057|UMLS:C1518271|Wikipedia:Neuroectoderm|EHDAA2:0001248|VHOG:0000150|EHDAA:1498|XAO:0000042|EV:0100004|EHDAA:255|ZFA:0001120|FMA:87657|BILA:0000039|EMAPA:16073|TAO:0001120|MAT:0000176|AAO:0011074|MIAA:0000176	hp.json	neuroectoderm|ventral neurogenic region|epithelium tubi neuralis; neuroectoderma|presumptive central nervous system|neuaral ectoderm|neural ectoderm|epithelium tubi neuralis; neuroectoderma	http://purl.obolibrary.org/obo/UBERON_0002346		uberon_slim|vertebrate_core
UBERON:0002345	biolink:AnatomicalEntity	descending thoracic aorta	The part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest.	EFO:0002527|FMA:87217|MA:0002572|EMAPA:18605	hp.json		http://purl.obolibrary.org/obo/UBERON_0002345		pheno_slim|efo_slim|human_reference_atlas
UBERON:0002348	biolink:AnatomicalEntity	epicardium	A region of the serous membrane that forms the innermost layer of the pericardium and the outer surface of the heart.	galen:Epicardium|VHOG:0000119|EHDAA2:0002202|ZFA:0005057|UMLS:C0225968|Wikipedia:Epicardium|FMA:9461|TAO:0005057|XAO:0000316|NCIT:C13164|AAO:0010409	hp.json	visceral serous pericardium of heart|heart epicardium|pericardium visceral mesothelium|visceral serous pericardium proper	http://purl.obolibrary.org/obo/UBERON_0002348		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas
UBERON:0002347	biolink:AnatomicalEntity	thoracic vertebra	A thoracic vertebra endochondral element that is composed primarily of a bone tissue.	MESH:D013904|MA:0000314|FMA:9139|OpenCyc:Mx4rvdZIBpwpEbGdrcN5Y29ycA|GAID:244|NCIT:C12798|EMAPA:18011|UMLS:C0039987	hp.json	thorax vertebra|vertebra thoracica|dorsal vertebra|vertebra of thorax	http://purl.obolibrary.org/obo/UBERON_0002347		uberon_slim|pheno_slim
UBERON:0002342	biolink:AnatomicalEntity	neural crest	A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].	EHDAA2:0004419|ZFA:0000045|EMAPA:32737|AAO:0010578|Wikipedia:Neural_crest|TAO:0000045|NCIT:C34222|FMA:86666|BTO:0001764|MAT:0000066|GAID:1310|SCTID:361462002|CALOHA:TS-0676|VHOG:0000057|MIAA:0000066|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1366|MESH:D009432|XAO:0000048|UMLS:C0027789	hp.json	NC|neural crest material|crista neuralis|crista neuralis	http://purl.obolibrary.org/obo/UBERON_0002342		vertebrate_core|pheno_slim|uberon_slim
UBERON:0002343	biolink:AnatomicalEntity	abdomen musculature	Set of all muscles in abdomen.	TAO:0001327|FMA:71294|ZFA:0001327|FMA:86917	hp.json	muscle group of abdomen|muscles of abdomen|musculature of abdomen|musculature of abdominal wall|set of muscles of abdomen|abdominal musculature	http://purl.obolibrary.org/obo/UBERON_0002343		vertebrate_core|pheno_slim
UBERON:0002328	biolink:AnatomicalEntity	notochord	A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube.	EMAPA:16191|EHDAA:6021|VHOG:0000199|UMLS:C0028439|http://evolution.berkeley.edu/evolibrary/images/history/notochords.jpg|MAT:0000281|VSAO:0000032|MESH:D009672|ZFA:0000135|AAO:0000327|Wikipedia:Notochord|XAO:0000055|SCTID:308820002|CALOHA:TS-0690|BTO:0001768|TAO:0000135|EV:0100002|EHDAA2:0001277|EHDAA:1241|NCIT:C12463|GAID:1311|FMA:85521	hp.json	notochorda|embryonic notocord|notocord|notochorda	http://purl.obolibrary.org/obo/UBERON_0002328		uberon_slim|vertebrate_core|pheno_slim
UBERON:0002327	biolink:AnatomicalEntity	trunk of intercostal nerve		EMAPA:18227|FMA:85315|MA:0001176|EMAPA:37720	hp.json	intercostal nerve trunk|intercostal neural trunk	http://purl.obolibrary.org/obo/UBERON_0002327		
UBERON:0002329	biolink:AnatomicalEntity	somite	Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.	EMAPA:31169|AEO:0001015|MIAA:0000068|UMLS:C0376449|XAO:0000058|AAO:0010569|EHDAA:699|GAID:1306|ZFA:0000155|Wikipedia:Somite|NCIT:C34302|EHDAA2:0003436|EHDAA:366|BTO:0001558|MESH:D019170|TAO:0000155|VHOG:0000191|MAT:0000068|FMA:85522	hp.json	mesodermal cluster|somitic mesoderm|epithelial somite|epimere mesoderm|epimere|somitus|epithelial somite|somites|somitus	http://purl.obolibrary.org/obo/UBERON_0002329		uberon_slim|vertebrate_core|pheno_slim
GO:1900543	biolink:BiologicalProcess	negative regulation of purine nucleotide metabolic process	Any process that stops, prevents or reduces the frequency, rate or extent of purine nucleotide metabolic process.		hp.json	downregulation of purine metabolism|inhibition of purine metabolic process|down-regulation of purine nucleotide metabolic process|downregulation of purine nucleotide metabolism|inhibition of purine metabolism|downregulation of purine metabolic process|down regulation of purine nucleotide metabolic process|negative regulation of purine metabolism|down regulation of purine nucleotide metabolism|down-regulation of purine metabolism|down regulation of purine metabolic process|inhibition of purine nucleotide metabolism|downregulation of purine nucleotide metabolic process|inhibition of purine nucleotide metabolic process|negative regulation of purine nucleotide metabolism|down-regulation of purine nucleotide metabolism|down regulation of purine metabolism|negative regulation of purine metabolic process|down-regulation of purine metabolic process	http://purl.obolibrary.org/obo/GO_1900543		
CL:2000044	biolink:Cell	brain microvascular endothelial cell	Any microvascular endothelial cell that is part of a brain.		hp.json		http://purl.obolibrary.org/obo/CL_2000044		
GO:1900542	biolink:BiologicalProcess	regulation of purine nucleotide metabolic process	Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process.		hp.json	regulation of purine nucleotide metabolism|regulation of purine metabolic process|regulation of purine metabolism	http://purl.obolibrary.org/obo/GO_1900542		
CL:2000047	biolink:Cell	brainstem motor neuron	Any motor neuron that is part of a brainstem.		hp.json		http://purl.obolibrary.org/obo/CL_2000047		
GO:0044058	biolink:BiologicalProcess	regulation of digestive system process	Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.		hp.json		http://purl.obolibrary.org/obo/GO_0044058		
GO:1900544	biolink:BiologicalProcess	positive regulation of purine nucleotide metabolic process	Any process that activates or increases the frequency, rate or extent of purine nucleotide metabolic process.		hp.json	up regulation of purine nucleotide metabolic process|activation of purine nucleotide metabolic process|up-regulation of purine metabolism|positive regulation of purine metabolic process|positive regulation of purine nucleotide metabolism|up regulation of purine nucleotide metabolism|up regulation of purine metabolism|up regulation of purine metabolic process|upregulation of purine nucleotide metabolic process|positive regulation of purine metabolism|activation of purine nucleotide metabolism|up-regulation of purine metabolic process|up-regulation of purine nucleotide metabolism|upregulation of purine metabolism|activation of purine metabolism|up-regulation of purine nucleotide metabolic process|activation of purine metabolic process|upregulation of purine nucleotide metabolism|upregulation of purine metabolic process	http://purl.obolibrary.org/obo/GO_1900544		
CL:2000046	biolink:Cell	ventricular cardiac muscle cell	Any cardiac muscle cell that is part of a cardiac ventricle.		hp.json		http://purl.obolibrary.org/obo/CL_2000046		
GO:0044057	biolink:BiologicalProcess	regulation of system process	Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.		hp.json		http://purl.obolibrary.org/obo/GO_0044057		
CL:2000042	biolink:Cell	embryonic fibroblast	Any fibroblast that is part of a embryo.		hp.json		http://purl.obolibrary.org/obo/CL_2000042		
UBERON:0004998	biolink:AnatomicalEntity	mucosa of pylorus	A mucosa that is part of a pylorus [Automatically generated definition].	BTO:0004110|EMAPA:27199|FMA:17461	hp.json	stomach pyloric region mucosa of organ|pyloric part of stomach mucosa of organ|organ mucosa of pyloric part of stomach|mucous membrane of pyloric part of stomach|mucosa of pyloric part of stomach|pylorus mucosa|stomach pyloric region mucous membrane|pylorus organ mucosa|antropyloric mucosa|mucosa of organ of stomach pyloric region|pyloric part of stomach mucous membrane|mucosa of organ of pyloric part of stomach|mucous membrane of pylorus|pylorus mucosa of organ|organ mucosa of pylorus|mucosa of stomach pyloric region|organ mucosa of stomach pyloric region|mucous membrane of stomach pyloric region|pyloric part of stomach mucosa|pyloric part of stomach organ mucosa|stomach pyloric region mucosa|pylorus mucous membrane|mucosa of organ of pylorus|stomach pyloric region organ mucosa	http://purl.obolibrary.org/obo/UBERON_0004998		
UBERON:0002334	biolink:AnatomicalEntity	submandibular duct	The duct of the submadibular gland that opens at the sublingual papilla near the frenulum of the tongue.	NCIT:C33649|MA:0002698|UMLS:C0227472|EMAPA:35833|BTO:0004556|FMA:86266	hp.json	ductus submaxillaris|submaxillar gland duct|ductus submandibularis|submandibular salivary duct|submaxillary duct|Wharton's duct	http://purl.obolibrary.org/obo/UBERON_0002334		uberon_slim|pheno_slim
CHEBI:176497	biolink:ChemicalSubstance	geroprotector	Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.	PMID:30885572|PMID:28580190|PMID:33144142|PMID:23372317|PMID:34606237|PMID:33973253|Wikipedia:Geroprotector	hp.json	anti-aging agents|geroprotectors|geroprotective agents|geroprotective agent|anti-aging agent|anti-aging drugs|anti-aging drug	http://purl.obolibrary.org/obo/CHEBI_176497		3_STAR
UBERON:0004999	biolink:AnatomicalEntity	mucosa of biliary tree	A mucosa that is part of a biliary tree [Automatically generated definition].	FMA:14695	hp.json	biliary tree mucosa of organ|organ mucosa of biliary tract|biliary tract mucosa of organ|mucous membrane of biliary tract|mucosa of biliary tract|biliary tree mucous membrane|biliary tract mucosa|biliary tract organ mucosa|mucosa of organ of biliary tract|mucosa of organ of biliary tree|biliary tract mucous membrane|biliary tree mucosa|biliary tree organ mucosa|mucous membrane of biliary tree|organ mucosa of biliary tree	http://purl.obolibrary.org/obo/UBERON_0004999		
UBERON:0002337	biolink:AnatomicalEntity	endometrial stroma	The layer of connective tissue comprised of the endometrial lining of the uterus which fluctuates in thickness throughout the menstrual cycle.	UMLS:C0227849|NCIT:C32516|EMAPA:35310|MA:0002734|CALOHA:TS-1266|SCTID:254115004|FMA:86487	hp.json	stroma of endometrium|endometrium stroma	http://purl.obolibrary.org/obo/UBERON_0002337		human_reference_atlas
UBERON:0004997	biolink:AnatomicalEntity	mucosa of pyloric antrum	A mucosa that is part of a pyloric antrum [Automatically generated definition].	FMA:17055|BTO:0004107	hp.json	mucosa of organ of pyloric antrum|stomach pyloric antrum mucosa of organ|organ mucosa of antrum of stomach|mucous membrane of antrum of stomach|antrum of stomach mucosa of organ|mucosa of antrum of stomach|pyloric antrum mucosa|pyloric antrum organ mucosa|stomach pyloric antrum mucous membrane|organ mucosa of pyloric antrum|mucous membrane of pyloric antrum|antrum of stomach mucous membrane|mucosa of organ of antrum of stomach|mucosa of organ of stomach pyloric antrum|pyloric antrum mucosa of organ|antrum of stomach mucosa|mucosa of stomach pyloric antrum|antral mucosa|mucous membrane of stomach pyloric antrum|antrum of stomach organ mucosa|organ mucosa of stomach pyloric antrum|stomach pyloric antrum mucosa|gastric antrum mucosa|stomach pyloric antrum organ mucosa|pyloric antrum mucous membrane	http://purl.obolibrary.org/obo/UBERON_0004997		
UBERON:0002336	biolink:AnatomicalEntity	corpus callosum	White matter structure containing massive numbers of commissural fibers connecting cortical areas in the two cerebral hemispheres.it is subdivided into a genu, a rostrum, a body, and a splenium. (MM).	MIAA:0000286|BM:Tel-CC|OpenCyc:Mx4rvbNzdZwpEbGdrcN5Y29ycA|EMAPA:35253|EV:0100305|VHOG:0001608|EFO:0001390|BTO:0000615|NCIT:C12446|HBA:9222|GAID:683|BIRNLEX:1087|MESH:D003337|MA:0000188|DHBA:10561|MBA:776|CALOHA:TS-0180|MAT:0000286|BAMS:CC|UMLS:C0010090|BAMS:cc|FMA:86464|UMLS:C0010090	hp.json		http://purl.obolibrary.org/obo/UBERON_0002336		uberon_slim|pheno_slim|efo_slim
UBERON:0002331	biolink:AnatomicalEntity	umbilical cord	The connecting cord from the developing embryo to the placenta.	EMAPA:26115|MESH:D014470|MAT:0000280|CALOHA:TS-1078|OpenCyc:Mx4rvyewDJwpEbGdrcN5Y29ycA|EV:0100127|MIAA:0000280|EHDAA:158|EHDAA2:0000312|EFO:0001415|BTO:0001415|NCIT:C34320|GAID:517|FMA:85541|UMLS:C0041633	hp.json	connecting stalk|birth cord|funiculus umbilicalis|chorda umbilicalis|yolk stalk|funiculus umbilicalis	http://purl.obolibrary.org/obo/UBERON_0002331		uberon_slim|pheno_slim|efo_slim
UBERON:0004995	biolink:AnatomicalEntity	mucosa of body of stomach	A mucosa that is part of a body of stomach [Automatically generated definition].	FMA:17054	hp.json	gastric body mucosa|stomach body mucosa of organ|gastric body organ mucosa|organ mucosa of corpus gastricum (ventriculare)|mucous membrane of corpus gastricum (ventriculare)|corpus gastricum (ventriculare) mucosa of organ|mucosa of organ of gastric body|mucosa of corpus gastricum (ventriculare)|mucosa of organ of body of stomach|body of stomach mucous membrane|mucosa of gastric body|stomach body mucous membrane|mucosa of organ of corpus gastricum (ventriculare)|corpus gastricum (ventriculare) mucous membrane|mucous membrane of gastric body|organ mucosa of gastric body|mucosa of organ of stomach body|corpus gastricum (ventriculare) mucosa|gastric body mucosa of organ|corpus gastricum (ventriculare) organ mucosa|stomach body mucosa|stomach body organ mucosa|body of stomach mucosa|mucosa of stomach body|body of stomach organ mucosa|organ mucosa of stomach body|mucous membrane of stomach body|body of stomach mucosa of organ|organ mucosa of body of stomach|gastric body mucous membrane|mucous membrane of body of stomach	http://purl.obolibrary.org/obo/UBERON_0004995		
UBERON:0002330	biolink:AnatomicalEntity	exocrine system	Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia].	UMLS:C1516995|FMA:85539|CALOHA:TS-2057|MA:0002411|Wikipedia:Exocrine_gland|EHDAA2:0002225|EMAPA:35329|WikipediaCategory:Exocrine_system|NCIT:C12957	hp.json	exocrine glandular system	http://purl.obolibrary.org/obo/UBERON_0002330		uberon_slim|pheno_slim
UBERON:0002333	biolink:AnatomicalEntity	pulmonary trunk	An arterial trunk which is continuous with the heart and branches into the pulmonary arteries.	OpenCyc:Mx4rv-6d0ZwpEbGdrcN5Y29ycA|VHOG:0001134|galen:PulmonaryTrunk|FMA:8612|EMAPA:17015|EHDAA2:0001576|MA:0002033|EHDAA:9831|NCIT:C116918	hp.json	pulmonary artery (trunk)|main pulmonary artery|trunk of pulmonary arterial tree|main pulmonary artery	http://purl.obolibrary.org/obo/UBERON_0002333		uberon_slim|pheno_slim|efo_slim|human_reference_atlas
UBERON:0004992	biolink:AnatomicalEntity	mucosa of descending colon	A mucosa that is part of a descending colon [Automatically generated definition].	FMA:15019	hp.json	descending colon mucosa of organ|descending colon mucosa|descending colon organ mucosa|descending colon mucous membrane|mucosa of organ of descending colon|organ mucosa of descending colon|mucous membrane of descending colon	http://purl.obolibrary.org/obo/UBERON_0004992		
UBERON:0004993	biolink:AnatomicalEntity	mucosa of sigmoid colon	A mucosa that is part of a sigmoid colon [Automatically generated definition].	FMA:15026	hp.json	sigmoid colon mucous membrane|mucosa of organ of sigmoid colon|sigmoid colon mucosa|sigmoid colon organ mucosa|organ mucosa of sigmoid colon|sigmoid colon mucosa of organ|mucous membrane of sigmoid colon	http://purl.obolibrary.org/obo/UBERON_0004993		
UBERON:0014382	biolink:AnatomicalEntity	collection of hairs on head or neck	A collection of hairs that is part of a craniocervical region.		hp.json		http://purl.obolibrary.org/obo/UBERON_0014382		
UBERON:0014385	biolink:AnatomicalEntity	aryepiglottic fold	The entrance of the larynx is a triangular opening, narrow in front, wide behind, and sloping obliquely downward and backward. It is bounded, in front, by the epiglottis; behind, by the apices of the arytenoid cartilages, the corniculate cartilages, and the interarytenoid notch; and on either side, by a fold of mucous membrane, enclosing ligamentous and muscular fibers, stretched between the side of the epiglottis and the apex of the arytenoid cartilage; this is the aryepiglottic fold, on the posterior part of the margin of which the cuneiform cartilage forms a more or less distinct whitish prominence, the cuneiform tubercle. These folds form the upper borders of the quadrangular membrane.	NCIT:C32147|UMLS:C1510944|FMA:55448	hp.json	aryepiglottis|plica aryepiglottica|aryepiglottic sphincter|ary-epiglottic fold|aryepiglottic folds	http://purl.obolibrary.org/obo/UBERON_0014385		pheno_slim
GO:0044062	biolink:BiologicalProcess	regulation of excretion	Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.		hp.json		http://purl.obolibrary.org/obo/GO_0044062		
GO:0044060	biolink:BiologicalProcess	regulation of endocrine process	Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.		hp.json	regulation of endocrine system process	http://purl.obolibrary.org/obo/GO_0044060		
HGNC:9958	biolink:Gene	REN (human)	A protein coding gene REN in human.		hp.json		http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9958		
UBERON:0014381	biolink:AnatomicalEntity	whorl of hair	A patch of hair growing in the opposite direction of the rest of the hair.		hp.json	hair whorl|whorl	http://purl.obolibrary.org/obo/UBERON_0014381		pheno_slim
UBERON:0014386	biolink:AnatomicalEntity	vertebral endplate	Either of the the top and bottom portions of the vertebral bodies that interface with the vertebral discs. It is composed of a layer of thickened cancellous bone.	BTO:0005552|FMA:293500	hp.json	endplate	http://purl.obolibrary.org/obo/UBERON_0014386		pheno_slim
HP:0006817	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the cerebellar vermis	Absence or underdevelopment of the vermis of cerebellum.	UMLS:C1855676|UMLS:C3280770	hp.json	Hypo/aplastic vermis|Cerebellar vermis aplasia/hypoplasia|Cerebellar vermis aplasia or hypoplasia	http://purl.obolibrary.org/obo/HP_0006817		
UBERON:0014387	biolink:AnatomicalEntity	mesenchyme derived from neural crest	Mesenchyme that develops_from the neural crest[Automatically generated definition].	FMA:293883|EMAPA:32735	hp.json	neural crest derived mesenchyme|mesenchyme from neural crest|neural crest mesenchyme	http://purl.obolibrary.org/obo/UBERON_0014387		
UBERON:0014388	biolink:AnatomicalEntity	kidney collecting duct epithelium	The simple cuboidal epithelium lining the lumen of kidney collecting ducts.	EMAPA:37885	hp.json	epithelium of collecting duct of renal tubule|collecting duct of renal tubule epithelium|epithelium of renal collecting tubule	http://purl.obolibrary.org/obo/UBERON_0014388		pheno_slim
HP:0006818	biolink:PhenotypicFeature	4-layered lissencephaly	A form of lissencephaly in which the cortex is thickened and has four more or less disorganized layers rather than six normal layers resulting from incomplete neuronal migration during brain development. At neuropathological examination, a 4-layered cortex consists of an upper molecular layer, a second thin cellular layer containing pyramidal neurons usually observed in layer V, a third pale poorly cellular layer and a fourth thick deep layer made up of neurons which had failed to migrate. Radiologocally would manifest as agyria or pachygyria with cortical thickness greater than 10 mm.	UMLS:C0431375|SNOMEDCT_US:253147000|MSH:D054221	hp.json	Four-layered lissencephaly|Lissencephaly, type I|Type I lissencephaly|Classic lissencephaly|Type 1 lissencephaly	http://purl.obolibrary.org/obo/HP_0006818		
GO:0044065	biolink:BiologicalProcess	regulation of respiratory system process	Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.		hp.json		http://purl.obolibrary.org/obo/GO_0044065		
UBERON:0014389	biolink:AnatomicalEntity	gustatory papilla of tongue	A papilla that contain taste buds, including the fungiform, foliate, and circumvallate papillae.	FMA:54822	hp.json	taste papillae|taste papilla|gustatory papillae|gustatory papilla	http://purl.obolibrary.org/obo/UBERON_0014389		
HP:0006812	biolink:PhenotypicFeature	White mater abnormalities in the posterior periventricular region		UMLS:C1836525	hp.json		http://purl.obolibrary.org/obo/HP_0006812		
HP:0006813	biolink:PhenotypicFeature	Focal hemiclonic seizure	A type of focal clonic seizure characterized by sustained rhythmic jerking rapidly involves one side of the body at seizure onset.	UMLS:C1846620	hp.json	Unilateral clonic seizure|Hemiclonic seizure|Unilateral clonic seizures|Hemiclonic seizures	http://purl.obolibrary.org/obo/HP_0006813		
CHEBI:35735	biolink:ChemicalSubstance	dicarboxylic acid monoamide		KEGG:C04131	hp.json	dicarboxylic acid monoamides	http://purl.obolibrary.org/obo/CHEBI_35735		3_STAR
UBERON:0014371	biolink:AnatomicalEntity	future telencephalon	Embryonic structure that gives rise to the telencephalon.	TAO:0000571|EMAPA:36024|ZFA:0000571|EHDAA2:0004424	hp.json	presumptive telencephalon	http://purl.obolibrary.org/obo/UBERON_0014371		
GO:0071671	biolink:BiologicalProcess	regulation of smooth muscle cell chemotaxis	Any process that modulates the frequency, rate, or extent of smooth muscle cell chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_0071671		
GO:0071670	biolink:BiologicalProcess	smooth muscle cell chemotaxis	The directed movement of a smooth muscle cell in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0071670		
GO:0044070	biolink:BiologicalProcess	regulation of anion transport	Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0044070		
HP:0006827	biolink:PhenotypicFeature	Atrophy of the spinal cord		UMLS:C1389102	hp.json	Degeneration of the spinal cord	http://purl.obolibrary.org/obo/HP_0006827		
UBERON:0014375	biolink:AnatomicalEntity	intrinsic muscle of manus	Any of the intrinsic muscles of the manus (hand).	FMA:42380	hp.json	intrinsic muscle of hand|intrinsic hand muscle	http://purl.obolibrary.org/obo/UBERON_0014375		
UBERON:0014376	biolink:AnatomicalEntity	thenar muscle	Any of the muscles of the thenar eminence, a raised fleshy area on the palm of the hand near the base of the thumb.	FMA:64916	hp.json	thenar compartment|thenar muscles|thenar eminence|thenar muscle	http://purl.obolibrary.org/obo/UBERON_0014376		pheno_slim
HP:0006829	biolink:PhenotypicFeature	Severe muscular hypotonia	A severe degree of muscular hypotonia characterized by markedly reduced muscle tone.	UMLS:C1839630	hp.json	Hypotonia, severe|Severely decreased muscle tone	http://purl.obolibrary.org/obo/HP_0006829		
UBERON:0014378	biolink:AnatomicalEntity	intrinsic muscle of pes	Any of the intrinsic muscles of the pes (foot).	FMA:65020	hp.json	intrinsic muscle of foot	http://purl.obolibrary.org/obo/UBERON_0014378		
UBERON:0002393	biolink:AnatomicalEntity	pharyngotympanic tube	Organ with organ cavity which connects the cavity of the middle ear to the cavity of the pharynx. Examples: There are only two pharyngotympanic tubes, the right and the left pharyngotympanic tubes.[FMA].	GAID:869|FMA:9705|UMLS:C0015183|EMAPA:17601|VHOG:0001145|XAO:0000213|EV:0100359|MA:0000255|NCIT:C12500|AAO:0011016|AAO:0000146	hp.json	internal auditory tube|pharyngo-tympanic tube|eustachian tube|auditory tube|tuba auditiva|tuba pharyngotympanica|tuba auditoria|tuba auditiva; tuba auditoria; tuba auditivea	http://purl.obolibrary.org/obo/UBERON_0002393		uberon_slim|organ_slim|pheno_slim
CHEBI:35740	biolink:ChemicalSubstance	liposaccharide			hp.json	liposaccharides	http://purl.obolibrary.org/obo/CHEBI_35740		3_STAR
UBERON:0002392	biolink:AnatomicalEntity	nasolacrimal duct	The paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity.	GAID:902|VHOG:0000664|NCIT:C33161|MESH:D009301|UMLS:C0027437|FMA:9703|EMAPA:17853|EHDAA:7849|EHDAA2:0001237|MA:0001299|EHDAA:9094|AAO:0000643|OpenCyc:Mx4rv6PJy5wpEbGdrcN5Y29ycA	hp.json	tear duct|d. nasolacrimalis|nasolacrimal duct - posterior naris	http://purl.obolibrary.org/obo/UBERON_0002392		uberon_slim|pheno_slim
HP:0006824	biolink:PhenotypicFeature	Cranial nerve paralysis		SNOMEDCT_US:73013002|UMLS:C0151311|MSH:D003389|UMLS:C4025709	hp.json	Cranial nerve palsy|Cranial nerve palsies|Cranial nerve paresis	http://purl.obolibrary.org/obo/HP_0006824		
UBERON:0002395	biolink:AnatomicalEntity	talus	A proximal tarsal bone resulting from fusion of intermedium and fibulare.	FMA:9708|BTO:0002354|NCIT:C52799|MESH:D013628|galen:Talus|EMAPA:19135|UMLS:C0039277|GAID:196|MA:0001351	hp.json	astragalus bone|os tarsi tibiale|astragalus|astragaloid bone|major ankle bone|os trigonum	http://purl.obolibrary.org/obo/UBERON_0002395		pheno_slim|uberon_slim
HP:0006825	biolink:PhenotypicFeature	Pallor of dorsal columns of the spinal cord	An abnormally pale appearance of the dorsal portion of the gray substance of the spinal cord. This finding can be observed by histological examination.	UMLS:C1865416	hp.json		http://purl.obolibrary.org/obo/HP_0006825		
UBERON:0002394	biolink:AnatomicalEntity	bile duct	Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine.	GAID:280|BTO:0000122|FMA:9706|OpenCyc:Mx4rvdCds5wpEbGdrcN5Y29ycA|VHOG:0000212|EV:0100091|XAO:0000134|AAO:0011019|MA:0000354|CALOHA:TS-0075|EHDAA2:0000741|ZFA:0001100|UMLS:C0005400|EMAPA:35171|MESH:D001652|TAO:0001100|NCIT:C12376	hp.json	biliary duct|gall duct|bile tube|hepatic duct	http://purl.obolibrary.org/obo/UBERON_0002394		uberon_slim|pheno_slim
CHEBI:35741	biolink:ChemicalSubstance	glycerolipid	Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acid-derived group is attached.	PMID:18606873	hp.json	glycerolipids	http://purl.obolibrary.org/obo/CHEBI_35741		3_STAR
CHEBI:35744	biolink:ChemicalSubstance	carbocyclic fatty acid	Any fatty acid containing a ring composed of carbon atoms.		hp.json	carbocyclic fatty acids	http://purl.obolibrary.org/obo/CHEBI_35744		3_STAR
HP:0006821	biolink:PhenotypicFeature	Frontal polymicrogyria	A type of polymicrogyria with a gradient of severity (anterior more severe than posterior) extending from frontal poles posteriorly to precentral gyrus and inferiorly to frontal operculum.	UMLS:C1847356	hp.json	Polymicrogyria, anterior to posterior gradient	http://purl.obolibrary.org/obo/HP_0006821		
UBERON:0002391	biolink:AnatomicalEntity	lymph	Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP].	NCIT:C13252|GAID:1186|MIAA:0000055|ZFA:0005658|MESH:D008196|CALOHA:TS-0580|BTO:0000855|MA:0002520|VHOG:0001590|EV:0100049|galen:Lymph|FMA:9671|OpenCyc:Mx4rvpDOU5wpEbGdrcN5Y29ycA|ENVO:02000041|MAT:0000055|UMLS:C0024202|EFO:0000871	hp.json	lympha	http://purl.obolibrary.org/obo/UBERON_0002391		efo_slim|uberon_slim|pheno_slim
UBERON:0002390	biolink:AnatomicalEntity	hematopoietic system	Anatomical system that is involved in the production of hematopoietic cells.	EMAPA:35402|TAO:0005023|UMLS:C0018957|MIAA:0000022|BTO:0000570|FMA:9667|XAO:0000122|MA:0002434|GAID:1008|EFO:0000798|Wikipedia:Haematopoiesis|SCTID:362587009|NCIT:C12909|CALOHA:TS-0449|EV:0100045|ZFA:0005023|AAO:0011002|MESH:D006413|VHOG:0001624|MAT:0000022	hp.json	hemopoietic system|haematopoietic system|haematological system|hematological system|organa haemopoietica|hematolymphoid system|haemopoietic system|Blutbildungssystem	http://purl.obolibrary.org/obo/UBERON_0002390		efo_slim|uberon_slim|vertebrate_core|pheno_slim
GO:0071677	biolink:BiologicalProcess	positive regulation of mononuclear cell migration	Any process that increases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.		hp.json	up regulation of mononuclear cell migration|stimulation of mononuclear cell migration|up-regulation of mononuclear cell migration|activation of mononuclear cell migration|upregulation of mononuclear cell migration	http://purl.obolibrary.org/obo/GO_0071677		
GO:0071676	biolink:BiologicalProcess	negative regulation of mononuclear cell migration	Any process that decreases the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.		hp.json	downregulation of mononuclear cell migration|down regulation of mononuclear cell migration|inhibition of mononuclear cell migration|down-regulation of mononuclear cell migration	http://purl.obolibrary.org/obo/GO_0071676		
UBERON:0002397	biolink:AnatomicalEntity	maxilla	The bone which normally forms the lateral upper jaw in osteichthyans, including tetrapods.	EHDAA2:0001068|MESH:D008437|ZFA:0000270|EMAPA:17639|MA:0001491|AAO:0000285|CALOHA:TS-2217|TAO:0000270|EHDAA:8043|NCIT:C26470|FMA:9711|VHOG:0001021|galen:Maxilla|UMLS:C0024947|GAID:220|VSAO:0000207	hp.json	upper jaw bone|maxillary bone|maxillae	http://purl.obolibrary.org/obo/UBERON_0002397		pheno_slim|uberon_slim|vertebrate_core
GO:0071675	biolink:BiologicalProcess	regulation of mononuclear cell migration	Any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0071675		
UBERON:0002396	biolink:AnatomicalEntity	vomer	The triangular flat bone of the nasal septum.	OpenCyc:Mx4rv6jKWZwpEbGdrcN5Y29ycA|ZFA:0000308|UMLS:C0242403|TAO:0000308|MESH:D055172|NCIT:C33888|FMA:9710|AAO:0000633|MA:0001496	hp.json	prevomer|vomer bone	http://purl.obolibrary.org/obo/UBERON_0002396		pheno_slim|uberon_slim|vertebrate_core
GO:0071674	biolink:BiologicalProcess	mononuclear cell migration	The movement of a mononuclear cell within or between different tissues and organs of the body.		hp.json		http://purl.obolibrary.org/obo/GO_0071674		
GO:0071673	biolink:BiologicalProcess	positive regulation of smooth muscle cell chemotaxis	Any process that activates or increases the frequency, rate, or extent of smooth muscle cell chemotaxis.		hp.json	stimulation of smooth muscle cell chemotaxis|upregulation of smooth muscle cell chemotaxis|up-regulation of smooth muscle cell chemotaxis|up regulation of smooth muscle cell chemotaxis|activation of smooth muscle cell chemotaxis	http://purl.obolibrary.org/obo/GO_0071673		
GO:0071672	biolink:BiologicalProcess	negative regulation of smooth muscle cell chemotaxis	Any process that stops, prevents, or reduces the frequency, rate, or extent of smooth muscle cell chemotaxis.		hp.json	down-regulation of smooth muscle cell chemotaxis|down regulation of smooth muscle cell chemotaxis|inhibition of smooth muscle cell chemotaxis|downregulation of smooth muscle cell chemotaxis	http://purl.obolibrary.org/obo/GO_0071672		
UBERON:0002398	biolink:AnatomicalEntity	manus	Distal segment of the fore limb, including carpal region, metacarpal region and digits.	BTO:0004668|MESH:D006225|GAID:56|EMAPA:17428|EHDAA2:0000728|OpenCyc:Mx4rvViGVZwpEbGdrcN5Y29ycA|VHOG:0000344|AAO:0010803|NLXANAT:20090603|CALOHA:TS-2213|NCIT:C32712|UMLS:C0018563|FMA:9712|galen:Hand|MA:0000037	hp.json	forefoot|forefoot of quadruped|forefeet|fore-paw|forepaw|forelimb autopod|hand|hand region|fore foot|forelimb autopodium|terminal segment of free upper limb|fore paw	http://purl.obolibrary.org/obo/UBERON_0002398		pheno_slim|uberon_slim
GO:0044085	biolink:BiologicalProcess	cellular component biogenesis	A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.		hp.json	cellular component biogenesis at cellular level	http://purl.obolibrary.org/obo/GO_0044085		goslim_pir
CL:2000013	biolink:Cell	fibroblast of skin of abdomen	Any skin fibroblast that is part of a skin of abdomen.		hp.json		http://purl.obolibrary.org/obo/CL_2000013		
GO:0044089	biolink:BiologicalProcess	positive regulation of cellular component biogenesis	Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.		hp.json		http://purl.obolibrary.org/obo/GO_0044089		
CHEBI:35718	biolink:ChemicalSubstance	antifungal agent	An  antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.		hp.json	antifungal agents|antifungal drugs|antifungal|antifungals|antifungal drug	http://purl.obolibrary.org/obo/CHEBI_35718		3_STAR
CL:2000010	biolink:Cell	dermis blood vessel endothelial cell	Any blood vessel endothelial cell that is part of a dermis.		hp.json		http://purl.obolibrary.org/obo/CL_2000010		
GO:0044087	biolink:BiologicalProcess	regulation of cellular component biogenesis	Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.		hp.json		http://purl.obolibrary.org/obo/GO_0044087		
GO:0044088	biolink:BiologicalProcess	regulation of vacuole organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.		hp.json	regulation of vacuole biogenesis|regulation of vacuole organisation	http://purl.obolibrary.org/obo/GO_0044088		
UBERON:0002382	biolink:AnatomicalEntity	rectus abdominis muscle	The rectus abdominis muscle is a paired muscle running vertically on each side of the anterior wall of the abdomen. There are two parallel sets of muscles, separated by a midline band of connective tissue called the linea alba (white line). It extends from the pubic symphysis/pubic crest inferiorly to the xiphisternum/xiphoid process and lower costal cartilages (5-7) superiorly. It is contained in the Rectus sheath. The rectus is usually crossed by three fibrous bands licked by the tendinous inscriptions. [WP,modified].	MESH:D017568|EMAPA:18164|EHDAA2:0001595|VHOG:0000863|FMA:9628|NCIT:C33449|EHDAA:8252|XAO:0004128|AAO:0010789|UMLS:C0206066|GAID:142|MA:0002364	hp.json	musculus rectus abdominis|m. rectus abdominis|rectus abdominis	http://purl.obolibrary.org/obo/UBERON_0002382		pheno_slim|uberon_slim|organ_slim
UBERON:0002381	biolink:AnatomicalEntity	pectoralis major	The pectoralis major is a thick, fan-shaped muscle, situated at the upper front of the chest wall. It makes up the bulk of the chest muscles in the male and lies under the breast in the female. Underneath the pectoralis major is the pectoralis minor, a thin, triangular muscle. [WP,unvetted].	NCIT:C33284|VHOG:0000895|EHDAA:8311|FMA:9627|EMAPA:18179|UMLS:C0585574|EHDAA2:0001424|MA:0002354	hp.json	pectoralis major muscle structure|musculus pectoralis major|pectoralis major muscle	http://purl.obolibrary.org/obo/UBERON_0002381		pheno_slim|uberon_slim|organ_slim
CL:2000019	biolink:Cell	compound eye photoreceptor cell	Any photoreceptor cell that is part of a compound eye.		hp.json		http://purl.obolibrary.org/obo/CL_2000019		
UBERON:0002384	biolink:AnatomicalEntity	connective tissue	Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance.	FMA:9640|SCTID:361919005|VSAO:0000017|MIAA:0000301|BTO:0000421|NCIT:C12374|CALOHA:TS-2009|AAO:0000098|galen:ConnectiveTissue|XAO:0001017|ZFA:0001632|UMLS:C0009780|OpenCyc:Mx4rv-aBgZwpEbGdrcN5Y29ycA|GAID:100|EMAPA:35251|MESH:D003238|TAO:0001641|MA:0000011|EFO:0000952|MAT:0000301	hp.json	portion of connective tissue|textus connectivus|Bindegewebe	http://purl.obolibrary.org/obo/UBERON_0002384		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
CL:2000016	biolink:Cell	lung microvascular endothelial cell	Any lung endothelial cell that is part of a microvascular endothelium.		hp.json		http://purl.obolibrary.org/obo/CL_2000016		
UBERON:0002380	biolink:AnatomicalEntity	trapezius muscle	A large superficial muscle that extends longitudinally from the occipital bone to the lower thoracic vertebrae and laterally to the spine of the scapula (shoulder blade). Its functions are to move the scapulae and support the arm. The trapezius has three functional regions: the superior region (descending part), which supports the weight of the arm; the intermediate region (transverse part), which retracts the scapulae; and the inferior region (ascending part), which medially rotates and depresses the scapulae. [WP,unvetted].	EMAPA:18183|UMLS:C0224361|FMA:9626|MA:0002398|VHOG:0000834|NCIT:C33809	hp.json	trapezius|spinotrapezius|musculus trapezius	http://purl.obolibrary.org/obo/UBERON_0002380		uberon_slim
UBERON:0002389	biolink:AnatomicalEntity	manual digit	A digit that is part of a manus (hand).	galen:Finger|BTO:0004669|GAID:57|MA:0000041|OpenCyc:Mx4rvVi_f5wpEbGdrcN5Y29ycA|NCIT:C32608|EMAPA:32642|MESH:D005385|UMLS:C0016129|NLXANAT:20090602|EHDAA2:0000404|AAO:0000857|FMA:9666|XAO:0003036	hp.json	forelimb digit|digit of hand|fore digit|hand digit|digitus manus|digit of manus|manual digit (phalangeal portion) plus soft tissue|finger	http://purl.obolibrary.org/obo/UBERON_0002389		pheno_slim|uberon_slim
UBERON:0002386	biolink:AnatomicalEntity	forelimb zeugopod	The middle limb segment of the pectoral free limb, between the autopod and stylopod segments. Includes as parts the forelimb zeugopodial skeleton, which includes as parts the radius and ulna, or their cartilage precursors, or evolutionary variants.	BTO:0001447|OpenCyc:Mx4rvVjnmpwpEbGdrcN5Y29ycA|MESH:D005542|GAID:55|NCIT:C32628|EMAPA:17417|CALOHA:TS-2205|galen:Forearm|EHDAA:4172|VHOG:0000341|UMLS:C0016536|EFO:0003053|VSAO:0005058|EHDAA:6218|MA:0000034|FMA:9663|EHDAA2:0000553	hp.json	zeugopod of brachial region|zeugopod of forelimb|regio antebrachialis|antebrachial region|forelimb epipodium|arm zeugopod|brachial region middle limb segment|middle limb segment of proximal segment of free upper limb|middle limb segment of arm|zeugopod of proximal segment of free upper limb|fore epipodium|zeugopod of arm|antebrachium|wing zeugopod|forearm|middle limb segment of forelimb|lower segment of arm|intermediate segment of free upper limb|lower arm|middle limb segment of brachial region|brachial region zeugopod|antibrachium|arm middle limb segment|forelimb zeugopodium|antebrachium|forelimb zygopod|antebrachium	http://purl.obolibrary.org/obo/UBERON_0002386		pheno_slim|efo_slim|uberon_slim
UBERON:0002385	biolink:AnatomicalEntity	muscle tissue	Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO].	EHDAA2:0003122|galen:MuscleTissue|CALOHA:TS-0642|AEO:0000122|MA:0002437|Wikipedia:Muscle_tissue|AAO:0000306|MESH:D009132|UMLS:C2328219|EMAPA:32715|NCIT:C12435|SCTID:91727004|FMA:9641	hp.json	muscular tissue|textus muscularis|portion of muscle tissue	http://purl.obolibrary.org/obo/UBERON_0002385		uberon_slim
UBERON:0002387	biolink:AnatomicalEntity	pes	Distal portion of the hind limb, including tarsal region, metatarsal region and digits.	MA:0000044|BTO:0000476|EMAPA:17459|GAID:40|CALOHA:TS-0377|EFO:0003065|OpenCyc:Mx4rvVi-k5wpEbGdrcN5Y29ycA|EHDAA2:0000546|VHOG:0000350|NCIT:C32622|MESH:D005528|galen:Foot|UMLS:C0016504|FMA:9664	hp.json	hindfoot|hindpaw|pes|hind paw|hindlimb autopodium|hindlimb distal free limb segment|hind-paw|hindfeet|hindlimb autopod|hind limb autopodium|foot|terminal segment of free lower limb|hind foot|hindfoot of quadruped	http://purl.obolibrary.org/obo/UBERON_0002387		pheno_slim|efo_slim|uberon_slim
GO:0071692	biolink:BiologicalProcess	protein localization to extracellular region	Any process in which a protein is transported from one specific location in the extracellular region to another, or maintained in a specific extracellular location.		hp.json	protein localisation in extracellular region|protein localization in extracellular region	http://purl.obolibrary.org/obo/GO_0071692		
PR:000045358	biolink:Protein	insulin family protein	A protein that is a translation product of a gene that encodes a standalone Insulin (Pfam:PF00049) domain preceded by a signal peptide.		hp.json	fam:INS	http://purl.obolibrary.org/obo/PR_000045358		
GO:0044092	biolink:BiologicalProcess	negative regulation of molecular function	Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.		hp.json		http://purl.obolibrary.org/obo/GO_0044092		
GO:0044093	biolink:BiologicalProcess	positive regulation of molecular function	Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.		hp.json		http://purl.obolibrary.org/obo/GO_0044093		
GO:0044090	biolink:BiologicalProcess	positive regulation of vacuole organization	Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.		hp.json	positive regulation of vacuole biogenesis|positive regulation of vacuole organisation	http://purl.obolibrary.org/obo/GO_0044090		
GO:0044091	biolink:BiologicalProcess	membrane biogenesis	A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane.		hp.json		http://purl.obolibrary.org/obo/GO_0044091		
CL:2000001	biolink:Cell	peripheral blood mononuclear cell	A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.		hp.json		http://purl.obolibrary.org/obo/CL_2000001		
CL:2000000	biolink:Cell	epidermal melanocyte	Any melanocyte that is part of a epidermis.		hp.json		http://purl.obolibrary.org/obo/CL_2000000		
HP:0006808	biolink:PhenotypicFeature	Cerebral hypomyelination	Reduced amount of myelin in the nervous system resulting from defective myelinogenesis in the white matter of the central nervous system.	UMLS:C2677328	hp.json	Hypomyelination of the brain	http://purl.obolibrary.org/obo/HP_0006808		
UBERON:0002371	biolink:AnatomicalEntity	bone marrow	The soft tissue that fills the cavities of bones.	VHOG:0001218|EV:0100046|NCIT:C12431|UMLS:C0005953|GAID:1287|FMA:9608|Wikipedia:Bone_marrow|MAT:0000084|BTO:0000829|EMAPA:32760|BTO:0000141|galen:BoneMarrow|EFO:0000868|MIAA:0000084|XAO:0000123|CALOHA:TS-0087|SCTID:421320006|MA:0000134|OpenCyc:Mx4rvVm-FpwpEbGdrcN5Y29ycA|AAO:0011007|MESH:D001853	hp.json	medulla ossium|medulla ossium|medulla ossea|medullary bone|medulla of bone	http://purl.obolibrary.org/obo/UBERON_0002371		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
HP:0006801	biolink:PhenotypicFeature	Hyperactive deep tendon reflexes		UMLS:C1846176	hp.json		http://purl.obolibrary.org/obo/HP_0006801		
HP:0006802	biolink:PhenotypicFeature	Abnormal anterior horn cell morphology	Any anomaly of the anterior horn cell.	MSH:D016472|UMLS:C0154681|SNOMEDCT_US:85672005|UMLS:C4020812	hp.json	Anterior horn cell disease|Anomaly of the anterior horn cells|Abnormality of the anterior horn cells|Abnormality of the anterior horn cell	http://purl.obolibrary.org/obo/HP_0006802		
UBERON:0002370	biolink:AnatomicalEntity	thymus	Anatomical structure of largely lymphoid tissue that functions in cell-mediated immunity by being the site where T cells develop.	MESH:D013950|EHDAA:9119|MA:0000142|TAO:0001078|EFO:0000860|FMA:9607|UMLS:C0040113|BTO:0001374|EMAPA:18768|VHOG:0000253|AAO:0010548|OpenCyc:Mx4rvpIympwpEbGdrcN5Y29ycA|MAT:0000080|GAID:464|EV:0100138|CALOHA:TS-1043|EHDAA2:0002017|ZFA:0001078|XAO:0000163|NCIT:C12433|MIAA:0000080	hp.json	thymus gland|thymus organ	http://purl.obolibrary.org/obo/UBERON_0002370		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|vertebrate_core|major_organ|organ_slim
CL:2000008	biolink:Cell	microvascular endothelial cell	Any blood vessel endothelial cell that is part of a microvascular endothelium.		hp.json		http://purl.obolibrary.org/obo/CL_2000008		
HP:0006803	biolink:PhenotypicFeature	Vivid hallucinations		UMLS:C4024978	hp.json		http://purl.obolibrary.org/obo/HP_0006803		
UBERON:0002372	biolink:AnatomicalEntity	tonsil	Either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx.	MA:0000143|UMLS:C1519547|EFO:0001401|OpenCyc:Mx4rvVivrZwpEbGdrcN5Y29ycA|VHOG:0001139|FMA:9609|BTO:0001387|MESH:D014066|EV:0100052|NCIT:C12802|EMAPA:35871|UMLS:C0836921|UMLS:C1519548|GAID:341|CALOHA:TS-1053	hp.json	Mandel	http://purl.obolibrary.org/obo/UBERON_0002372		pheno_slim|efo_slim|uberon_slim
CL:2000005	biolink:Cell	brain macroglial cell	Any macroglial cell that is part of a brain.		hp.json		http://purl.obolibrary.org/obo/CL_2000005		
CHEBI:35722	biolink:ChemicalSubstance	sulfated glycosaminoglycan			hp.json	sulfated glycosaminoglycans|glycosaminoglycan sulfate|glycosaminoglycan sulfates	http://purl.obolibrary.org/obo/CHEBI_35722		3_STAR
CHEBI:35721	biolink:ChemicalSubstance	heparan sulfates			hp.json		http://purl.obolibrary.org/obo/CHEBI_35721		1_STAR
CL:2000004	biolink:Cell	pituitary gland cell	Any cell that is part of a pituitary gland.		hp.json		http://purl.obolibrary.org/obo/CL_2000004		
CHEBI:35724	biolink:ChemicalSubstance	carbohydrate sulfate			hp.json	carbohydrate sulphates|carbohydrate sulfates	http://purl.obolibrary.org/obo/CHEBI_35724		3_STAR
UBERON:0002379	biolink:AnatomicalEntity	perineal muscle	Any muscle organ that is part of a perineum [Automatically generated definition].	EMAPA:36629|NCIT:C33300|MA:0000538|UMLS:C0224382|FMA:9623	hp.json	perineal region muscle organ|muscle organ of perineal region|perineum muscle organ|muscle organ of perineum|muscle of perineum	http://purl.obolibrary.org/obo/UBERON_0002379		
UBERON:0002378	biolink:AnatomicalEntity	muscle of abdomen	Muscle (organ) which is a part of the abdomen. Examples: external oblique, rectus abdominis.	FMA:9620|SCTID:361352008|GAID:89|NCIT:C32040|EMAPA:35103|Wikipedia:Abdominal_muscle|OpenCyc:Mx4rvlygNJwpEbGdrcN5Y29ycA|UMLS:C0000739|MESH:D000009|BTO:0001261|MA:0000520	hp.json	abdominal wall musculature|abdomen muscle organ|abdominal wall muscle|abdomen muscle|abdominal muscle|muscle organ of abdomen	http://purl.obolibrary.org/obo/UBERON_0002378		pheno_slim|uberon_slim
UBERON:0002375	biolink:AnatomicalEntity	cricoid cartilage	A cartilaginous ring that provides support for the arytenoid cartilages and forms the caudal part of the larynx.	GAID:110|VHOG:0001308|MESH:D003413|AAO:0000675|UMLS:C0010323|FMA:9615|EHDAA2:0000326|EHDAA:9393|MA:0001762|EMAPA:18696|NCIT:C32400	hp.json	cricoid|cartilago cricoidea|innominate cartilage|cartilago cricoidea|cricoidea|cartilago cricotrachealis|krykoid cartilage|cartilaginis cricoideae	http://purl.obolibrary.org/obo/UBERON_0002375		pheno_slim|uberon_slim
GO:0071697	biolink:BiologicalProcess	ectodermal placode morphogenesis	The process in which the anatomical structures of an ectodermal placode are generated and organized. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.		hp.json		http://purl.obolibrary.org/obo/GO_0071697		
UBERON:0002374	biolink:AnatomicalEntity	metacarpal bone	A bone that is part of the metacarpal skeleton.	NCIT:C12751|EFO:0003886|OpenCyc:Mx4rv1Bk45wpEbGdrcN5Y29ycA|EMAPA:36158|MA:0000302|FMA:9612|galen:Metacarpal|UMLS:C0025526	hp.json	metacarpal	http://purl.obolibrary.org/obo/UBERON_0002374		pheno_slim|efo_slim|uberon_slim
GO:0071696	biolink:BiologicalProcess	ectodermal placode development	The progression of an ectodermal placode over time from its initial formation until its mature state. An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm.		hp.json		http://purl.obolibrary.org/obo/GO_0071696		
UBERON:0002377	biolink:AnatomicalEntity	muscle of neck	Any muscle that is part of the cervical (neck) region.	UMLS:C0027532|EMAPA:36050|NCIT:C33163|FMA:9617|MESH:D009334|GAID:149|MA:0000587	hp.json	muscle organ of neck|neck (volume) muscle organ|neck muscle organ|neck muscle|muscle organ of neck (volume)	http://purl.obolibrary.org/obo/UBERON_0002377		pheno_slim|uberon_slim
GO:0071695	biolink:BiologicalProcess	anatomical structure maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state.		hp.json		http://purl.obolibrary.org/obo/GO_0071695		
UBERON:0002376	biolink:AnatomicalEntity	cranial muscle	Any skeletal muscle that is part of the head region.	EHDAA2:0000322|EFO:0003524|EMAPA:18172|FMA:9616|BTO:0000021|MA:0000578|AAO:0000107|ZFA:0001652|SCTID:244718003	hp.json	head muscles|muscle organ of head|muscle of head|cranial muscle|cephalic muscle|cephalic musculature|head muscle|head muscle organ|adult head muscle organ|muscle organ of adult head|musculus caput	http://purl.obolibrary.org/obo/UBERON_0002376		efo_slim|uberon_slim|vertebrate_core
GO:0009891	biolink:BiologicalProcess	positive regulation of biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.		hp.json	up regulation of biosynthetic process|stimulation of biosynthetic process|activation of biosynthetic process|up-regulation of biosynthetic process|positive regulation of anabolism|upregulation of biosynthetic process|positive regulation of synthesis|positive regulation of formation|positive regulation of biosynthesis	http://purl.obolibrary.org/obo/GO_0009891		
GO:0009892	biolink:BiologicalProcess	negative regulation of metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.		hp.json	down regulation of metabolic process|negative regulation of multicellular organismal metabolic process|inhibition of organismal metabolic process|negative regulation of organismal metabolism|downregulation of metabolic process|inhibition of metabolic process|negative regulation of metabolism|down-regulation of metabolic process	http://purl.obolibrary.org/obo/GO_0009892		
GO:0009893	biolink:BiologicalProcess	positive regulation of metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.		hp.json	upregulation of metabolic process|positive regulation of metabolism|up-regulation of metabolic process|positive regulation of multicellular organismal metabolic process|up-regulation of organismal metabolic process|up regulation of metabolic process|activation of metabolic process|positive regulation of organismal metabolism|stimulation of organismal metabolic process|stimulation of metabolic process	http://purl.obolibrary.org/obo/GO_0009893		
GO:0071806	biolink:BiologicalProcess	protein transmembrane transport	The process in which a protein is transported across a membrane.		hp.json	protein membrane transport	http://purl.obolibrary.org/obo/GO_0071806		
GO:0046849	biolink:BiologicalProcess	bone remodeling	The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.	Wikipedia:Bone_remodeling	hp.json	bone remodelling	http://purl.obolibrary.org/obo/GO_0046849		
GO:0009894	biolink:BiologicalProcess	regulation of catabolic process	Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances.		hp.json	regulation of degradation|regulation of catabolism|regulation of breakdown	http://purl.obolibrary.org/obo/GO_0009894		
GO:0019218	biolink:BiologicalProcess	regulation of steroid metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.		hp.json	regulation of steroid metabolism	http://purl.obolibrary.org/obo/GO_0019218		
GO:0009895	biolink:BiologicalProcess	negative regulation of catabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.		hp.json	negative regulation of breakdown|down-regulation of catabolic process|negative regulation of catabolism|down regulation of catabolic process|inhibition of catabolic process|negative regulation of degradation|downregulation of catabolic process	http://purl.obolibrary.org/obo/GO_0009895		
GO:0009896	biolink:BiologicalProcess	positive regulation of catabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances.		hp.json	up regulation of catabolic process|activation of catabolic process|stimulation of catabolic process|upregulation of catabolic process|positive regulation of degradation|positive regulation of catabolism|up-regulation of catabolic process|positive regulation of breakdown	http://purl.obolibrary.org/obo/GO_0009896		
GO:0019219	biolink:BiologicalProcess	regulation of nucleobase-containing compound metabolic process	Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.		hp.json	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism|regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	http://purl.obolibrary.org/obo/GO_0019219		
GO:0019216	biolink:BiologicalProcess	regulation of lipid metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.		hp.json	regulation of lipid metabolism	http://purl.obolibrary.org/obo/GO_0019216		
GO:0019217	biolink:BiologicalProcess	regulation of fatty acid metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.		hp.json	regulation of fatty acid metabolism	http://purl.obolibrary.org/obo/GO_0019217		
NBO:0000064	biolink:NamedThing	regulation of drinking behavior	"A feeding behavior associated with the intake or the frequency of intake or preference or manner of intake of liquids." [NBO:GVG]		hp.json	drinking behaviour	http://purl.obolibrary.org/obo/NBO_0000064		
NBO:0000063	biolink:NamedThing	regulation of eating behavior	"A feeding behavior associated with the intake or the frequency of intake or preference or manner of intake of food." [NBO:GVG]		hp.json	eating behaviour	http://purl.obolibrary.org/obo/NBO_0000063		
GO:0046852	biolink:BiologicalProcess	positive regulation of bone remodeling	Any process that activates or increases the frequency, rate or extent of bone remodeling.		hp.json	activation of bone remodeling|stimulation of bone remodeling|upregulation of bone remodeling|up-regulation of bone remodeling|up regulation of bone remodeling	http://purl.obolibrary.org/obo/GO_0046852		
GO:0046851	biolink:BiologicalProcess	negative regulation of bone remodeling	Any process that stops, prevents, or reduces the frequency, rate or extent of bone remodeling.		hp.json	down-regulation of bone remodeling|down regulation of bone remodeling|inhibition of bone remodeling|downregulation of bone remodeling	http://purl.obolibrary.org/obo/GO_0046851		
GO:0046850	biolink:BiologicalProcess	regulation of bone remodeling	Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.		hp.json		http://purl.obolibrary.org/obo/GO_0046850		
GO:0010893	biolink:BiologicalProcess	positive regulation of steroid biosynthetic process	Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.		hp.json		http://purl.obolibrary.org/obo/GO_0010893		
GO:0010894	biolink:BiologicalProcess	negative regulation of steroid biosynthetic process	Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.		hp.json		http://purl.obolibrary.org/obo/GO_0010894		
GO:0019228	biolink:BiologicalProcess	neuronal action potential	An action potential that occurs in a neuron.		hp.json	generation of action potential	http://purl.obolibrary.org/obo/GO_0019228		
NBO:0000079	biolink:NamedThing	feeding behavior	The act of bringing an object or substance into the body by swallowing, surrounding or absorbing it [NBO:SMAC]		hp.json	feeding behaviour	http://purl.obolibrary.org/obo/NBO_0000079		
GO:0019226	biolink:BiologicalProcess	transmission of nerve impulse	The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.		hp.json	conduction of nerve impulse|signal transmission along a neuron	http://purl.obolibrary.org/obo/GO_0019226		
GO:0019221	biolink:BiologicalProcess	cytokine-mediated signaling pathway	The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.		hp.json	cytokine and chemokine mediated signaling pathway|cytokine mediated signalling pathway	http://purl.obolibrary.org/obo/GO_0019221		
GO:0019222	biolink:BiologicalProcess	regulation of metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.		hp.json	regulation of multicellular organismal metabolic process|regulation of organismal metabolic process|regulation of metabolism	http://purl.obolibrary.org/obo/GO_0019222		goslim_metagenomics
NBO:0000075	biolink:NamedThing	playing behavior	A very broad category including the partial or complete performance of adult functional behaviors in non-functional contexts, as well as interactive behaviors peculiar to immature animals [NBO:AC]		hp.json	play	http://purl.obolibrary.org/obo/NBO_0000075		
CHEBI:59698	biolink:ChemicalSubstance	phosphoric acids	Compounds containing one or more phosphoric acid units.		hp.json		http://purl.obolibrary.org/obo/CHEBI_59698		3_STAR
NBO:0000073	biolink:NamedThing	chewing	The act of repeated grinding, tearing, and or crushing with teeth or jaws [NBO:SMAC]		hp.json	chew|gnaw|mastication	http://purl.obolibrary.org/obo/NBO_0000073		
CHEBI:72695	biolink:ChemicalSubstance	organic molecule	Any molecule that consists of at least one carbon atom as part of the electrically neutral entity.		hp.json	organic compounds|organic compound|organic molecules	http://purl.obolibrary.org/obo/CHEBI_72695		3_STAR
GO:0019220	biolink:BiologicalProcess	regulation of phosphate metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.		hp.json	regulation of phosphate metabolism	http://purl.obolibrary.org/obo/GO_0019220		
GO:0007218	biolink:BiologicalProcess	neuropeptide signaling pathway	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.		hp.json	neuropeptide signalling pathway	http://purl.obolibrary.org/obo/GO_0007218		
GO:0007216	biolink:BiologicalProcess	G protein-coupled glutamate receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.		hp.json	metabotropic glutamate receptor signalling pathway|metabotropic glutamate receptor signaling pathway|G-protein coupled glutamate receptor signaling pathway	http://purl.obolibrary.org/obo/GO_0007216		
GO:0007215	biolink:BiologicalProcess	glutamate receptor signaling pathway	The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.		hp.json	glutamate signalling pathway|glutamate signaling pathway	http://purl.obolibrary.org/obo/GO_0007215		
GO:0007210	biolink:BiologicalProcess	serotonin receptor signaling pathway	The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.		hp.json	serotonin receptor signalling pathway	http://purl.obolibrary.org/obo/GO_0007210		
GO:0044207	biolink:CellularComponent	translation initiation ternary complex	A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).		hp.json	Met-tRNA/eIF2.GTP ternary complex|translation initiation (ternary) complex	http://purl.obolibrary.org/obo/GO_0044207		
GO:0071826	biolink:BiologicalProcess	ribonucleoprotein complex subunit organization	Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex.		hp.json	protein-RNA complex subunit organization|RNA-protein complex subunit organization|ribonucleoprotein complex subunit organisation	http://purl.obolibrary.org/obo/GO_0071826		
NBO:0000043	biolink:NamedThing	bonding behavior	A behavior that occurs between two individuals, such as parent and child, and involves an emotional attachment that implies a special and focused relationship.		hp.json	forming of peer relationship	http://purl.obolibrary.org/obo/NBO_0000043		
GO:0046877	biolink:BiologicalProcess	regulation of saliva secretion	Any process that modulates the frequency, rate or extent of the regulated release of saliva from a cell or a tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0046877		
GO:0010876	biolink:BiologicalProcess	lipid localization	Any process in which a lipid is transported to, or maintained in, a specific location.		hp.json	lipid localisation	http://purl.obolibrary.org/obo/GO_0010876		
GO:0046872	biolink:MolecularActivity	metal ion binding	Binding to a metal ion.		hp.json	heavy metal binding|metal binding	http://purl.obolibrary.org/obo/GO_0046872		goslim_flybase_ribbon|goslim_drosophila|goslim_metagenomics|goslim_agr
GO:0009890	biolink:BiologicalProcess	negative regulation of biosynthetic process	Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances.		hp.json	negative regulation of formation|downregulation of biosynthetic process|down regulation of biosynthetic process|inhibition of biosynthetic process|down-regulation of biosynthetic process|negative regulation of biosynthesis|negative regulation of anabolism|negative regulation of synthesis	http://purl.obolibrary.org/obo/GO_0009890		
GO:0009880	biolink:BiologicalProcess	embryonic pattern specification	The process that results in the patterns of cell differentiation that will arise in an embryo.		hp.json	embryonic pattern formation|ventral/lateral system|embryonic pattern biosynthesis	http://purl.obolibrary.org/obo/GO_0009880		
GO:0010873	biolink:BiologicalProcess	positive regulation of cholesterol esterification	Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.		hp.json		http://purl.obolibrary.org/obo/GO_0010873		
CHEBI:84690	biolink:ChemicalSubstance	alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-Cer(d18:1/18:0)	A glycotriaosylceramide having alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl as the glycotriaosyl component attached to the Cer(d18:1/18:0).	LIPID_MAPS_instance:LMSP0502AA02	hp.json	Gb3(d18:1/18:0)|N-[(2S,3R,4E)-1-{[alpha-D-galactopyranosyl-(1->4)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy}-3-hydroxyoctadec-4-en-2-yl]octadecanamide	http://purl.obolibrary.org/obo/CHEBI_84690		3_STAR
GO:0046879	biolink:BiologicalProcess	hormone secretion	The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.		hp.json		http://purl.obolibrary.org/obo/GO_0046879		
GO:0010872	biolink:BiologicalProcess	regulation of cholesterol esterification	Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle.		hp.json		http://purl.obolibrary.org/obo/GO_0010872		
GO:0046878	biolink:BiologicalProcess	positive regulation of saliva secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of saliva.		hp.json	upregulation of saliva secretion|stimulation of saliva secretion|up regulation of saliva secretion|up-regulation of saliva secretion|activation of saliva secretion	http://purl.obolibrary.org/obo/GO_0046878		
GO:0009887	biolink:BiologicalProcess	animal organ morphogenesis	Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.		hp.json	histogenesis and organogenesis	http://purl.obolibrary.org/obo/GO_0009887		
GO:0009888	biolink:BiologicalProcess	tissue development	The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.	Wikipedia:Histogenesis	hp.json	histogenesis and organogenesis|histogenesis	http://purl.obolibrary.org/obo/GO_0009888		
GO:0009889	biolink:BiologicalProcess	regulation of biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.		hp.json	regulation of anabolism|regulation of synthesis|regulation of biosynthesis|regulation of formation	http://purl.obolibrary.org/obo/GO_0009889		
NBO:0000054	biolink:NamedThing	suckling behavior	"Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast." [GOC:dph]		hp.json	suckling behaviour|nursing behaviour	http://purl.obolibrary.org/obo/NBO_0000054		
UBERON:0004619	biolink:AnatomicalEntity	lumbar vertebra 3	The third lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	NCIT:C32901|FMA:13074|MA:0001430|UMLS:C0223522|EMAPA:19571	hp.json	L3 vertebra|third lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0004619		defined_by_ordinal_series|pheno_slim
UBERON:0004617	biolink:AnatomicalEntity	lumbar vertebra 1	The first lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	NCIT:C32899|UMLS:C0223492|FMA:13072|EMAPA:19472|MA:0001428	hp.json	L1 vertebra|first lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0004617		defined_by_ordinal_series
UBERON:0004618	biolink:AnatomicalEntity	lumbar vertebra 2	The second lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	NCIT:C32900|UMLS:C0223507|FMA:13073|EMAPA:19570|MA:0001429	hp.json	L2 vertebra|second lumbar vertebra	http://purl.obolibrary.org/obo/UBERON_0004618		defined_by_ordinal_series|pheno_slim
UBERON:0004615	biolink:AnatomicalEntity	mammalian cervical vertebra 6	The sixth of the seven cervical vertebrae[ncit,modified].	MA:0001426|EMAPA:19466|NCIT:C32244|FMA:12524|UMLS:C0459944	hp.json	cervical vertebra 6|C6 vertebra|sixth cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0004615		defined_by_ordinal_series|pheno_slim
UBERON:0004616	biolink:AnatomicalEntity	mammalian cervical vertebra 7	Vertebra prominens is the proper name for the seventh cervical vertebra. The most distinctive characteristic of this vertebra is the existence of a long and prominent spinous process which is palpable from the skin surface, hence the name. This spinous process is thick, nearly horizontal in direction, not bifurcated, but terminating in a tubercle to which the lower end of the ligamentum nuchae is attached. The seventh cervical vertebra (C7) has the most prominent spinous process only in about 70% of people; in the remainder, either C6 or T1 (the first thoracic vertebra) will be the most prominent. The transverse processes are of considerable size, their posterior roots are large and prominent, while the anterior are small and faintly marked; the upper surface of each has usually a shallow sulcus for the eighth spinal nerve, and its extremity seldom presents more than a trace of bifurcation. The foramen transversarium may be as large as that in the other cervical vertebrae, but is generally smaller on one or both sides; occasionally it is double, sometimes it is absent. On the left side it occasionally gives passage to the vertebral artery; more frequently the vertebral vein traverses it on both sides; but the usual arrangement is for both artery and vein to pass in front of the transverse process, and not through the foramen. Sometimes the anterior root of the transverse process attains a large size and exists as a separate bone, which is known as a cervical rib.	MA:0001427|UMLS:C0223176|EMAPA:19467|NCIT:C32245|FMA:12525	hp.json	vertebra prominens [C VII]|prominent vertebra|seventh cervical vertebra|cervical vertebra 7|vertebra prominens (CVII)|C7 vertebra	http://purl.obolibrary.org/obo/UBERON_0004616		defined_by_ordinal_series
GO:0046888	biolink:BiologicalProcess	negative regulation of hormone secretion	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.		hp.json	down regulation of hormone secretion|inhibition of hormone secretion|downregulation of hormone secretion|down-regulation of hormone secretion	http://purl.obolibrary.org/obo/GO_0046888		
HP:0031584	biolink:PhenotypicFeature	Tessier number 12 facial cleft	There is a soft tissue cleft medial to the inner canthus with a cleft of the root of the eyebrow. The frontal process of the maxilla is flat and broadened, and the ethmoid labyrinth is increased in tranverse dimension, thereby producing orbital hypertelorism. The cribriform plate is of normal width. The frontal sinus is enlarged. Even though the frontal bone is flattened, bony clefts with encephalocele have not been observed. There is a lateral displacement of the inner canthus with a mild thinning, aplasia, or irregularity of the medial end of the eyebrow. There are no eyelid clefts. The soft tissue contour of the forehead is normal, with only a short downward prolongation of the paramedian frontal hairline to mark the superior extent of the soft tissue cleft. Flattening of the frontal process of the maxilla, an increase in the transverse dimension of the ethmoid sinus, and a laterally convex bowing of the medial orbital wall produce orbital hypertelorism. Superiorly there is a minor flattening of the frontal bone medially, and the nasofrontal angle is somewhat obtuse. The extensive pneumatization of the sinuses on the cleft side extends backward through the frontal and ethmoid sinuses and into the sphenoid sinus. The anatomy of the sphenoid, including the pterygoid processes, is otherwise normal. The anterior and middle cranial fossae floors are both broadened on the cleft side with minor widening of the cribriform plate.		hp.json		http://purl.obolibrary.org/obo/HP_0031584		
GO:0046887	biolink:BiologicalProcess	positive regulation of hormone secretion	Any process that activates or increases the frequency, rate or extent of the regulated release of a hormone from a cell.		hp.json	up-regulation of hormone secretion|up regulation of hormone secretion|activation of hormone secretion|stimulation of hormone secretion|upregulation of hormone secretion	http://purl.obolibrary.org/obo/GO_0046887		
HP:0031585	biolink:PhenotypicFeature	Tessier number 13 facial cleft	There is a paramedian frontal encephalocele and a soft tissue cleft that passes medial to an intact eyebrow. The frontal bone shows a paramedian bony cleft with an associated encephalocele. The olfactory groove, cribriform plate, and ethmoid sinus are all increased in transverse diameter, resulting in hypertelorism. The cleft extends medially to the undisturbed eyebrow to end in a short paramedian frontal widow's peak. The bony cleft begins in the region of the nasal bone and extends superiorly through the full height of the frontal bone. Posteriorly, the cleft extends through the cribriform plate and ethmoid sinus as far as the lesser wing and body of the sphenoid. The pterygoid processes are anatomically normal, but they are displaced laterally from the midline on the cleft side. There is orbital hypertelorism below and asymmetry of the floor of the anterior cranial fossa above.		hp.json		http://purl.obolibrary.org/obo/HP_0031585		
HP:0031586	biolink:PhenotypicFeature	Tessier number 14 facial cleft	This midline cranial cleft usually occurs with a midline facial cleft that completes a median craniofacial dysraphia. A broad nasal root and bifid nose are associated with orbital hypertelorism and a median frontal encephalocele. The frontal bone abnormality varies from a minor flattening to a large midline defect. There is an increased distance between the olfactory grooves. The crista galli is widened, duplicated, or in some cases absent. Marked inferior prolapse of the enlarged ethmoid bone occurs with orbital hypertelorism. The severe orbital hypertelorism is associated with a broad flattening of the glabella and extreme lateral displacement of the inner canthi. The periorbita, including the eyelids and eyebrows, are otherwise normal. A long midline projection of the frontal hairline marks the superior extent of the soft tissue features of this midline cranial cleft. The median frontal defect delineates the region through which the frontal encephalocele herniates. The lateral segments of the frontal bone sweep upward from the region of the intact glabella and are flattened laterally. No pneumatization of the frontal sinus is evident. The crista galli and the perpendicular plate of the ethmoid are bifid. Just as the ethmoid, including the cribriform plate, is widened and caudally displaced, the sphenoid sinus is broadened and extensively, but symmetrically pneumatized. The lateral rotation of the greater and lesser wings of the sphenoid results in a relative shortening of the anteroposterior dimension of the middle cranial fossa. The floor of the anterior cranial fossa is upslanting from its medial aspect to its lateral aspect, with a harlequin appearance on the coronal scan.		hp.json	Tessier facial cleft number 14	http://purl.obolibrary.org/obo/HP_0031586		
GO:0010842	biolink:BiologicalProcess	retina layer formation	The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.		hp.json	retinal lamination|retinal layer formation	http://purl.obolibrary.org/obo/GO_0010842		
GO:0046886	biolink:NamedThing	positive regulation of hormone biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0046886		
HP:0031587	biolink:PhenotypicFeature	Tessier number 30 facial cleft	A lower midline facial cleft, also known as the median mandibular cleft. It is a rare anomaly, which may be limited to a defect in the soft tissue of the lower lip. However, in the more severe form, it may extend into the bony mandibular symphysis.		hp.json		http://purl.obolibrary.org/obo/HP_0031587		
GO:0046885	biolink:NamedThing	regulation of hormone biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0046885		
HP:0031580	biolink:PhenotypicFeature	Tessier number 8 facial cleft	The frontozygomatic or Number 8 cleft is found in both Treacher Collins syndrome and the Goldenhar variant of hemifacial microsomia. Skeletal defects are more prominent in Treacher Collins syndrome, whereas the soft tissue clefting is more typical in cases of ''Goldenhar syndrome''. Soft tissue clefting presents as a dermatocele, a true lateral eyelid coloboma with absence of the outer canthus, and anomalies of the globe itself, especially epibulbar cysts in patients with Goldenhar syndrome. The frontozygomatic bony cleft produces absence of the lateral orbital rim; this border now is formed by the hypoplastic greater wing of the sphenoid. The absence of bony support for the outer canthus produces lateral canthal dystopia and the characteristic antimongoloid slant of the palpebral fissures. Secondary to the bony deficiency in the lateral orbital wall and floor, there is soft tissue continuity between the orbit, temporal fossa, and infratemporal region. Preauricular hairline indicators delineate the Number 8 cleft as the first of the northbound clefts. Complete absence of the bony lateral orbital wall and rim constitute the skeletal element of the Number 8 cleft. The lateral border of the orbit is formed by the greater wing of the sphenoid from which small spicules of bone, which represent the rudimentary zygoma, may be found in Treacher Collins syndrome. The symmetry of the facial anomalies is reflected in the apparently normal symmetric anterior and middle cranial fossae.		hp.json	Tessier facial cleft number 8	http://purl.obolibrary.org/obo/HP_0031580		
HP:0031581	biolink:PhenotypicFeature	Tessier number 9 facial cleft	This is an upper lateral orbital cleft. The soft tissue deformity is in the lateral one-third of the upper eyelid, and the bony cleft is through the superolateral orbital angle. Microphthalmia is present. The superolateral bony deficiency of the orbits allows a lateral displacement of the globes. The lateral one-third of the upper eyelid and the outer canthus are distorted, thus preventing apposition to the globe. The upper eyelid does not have a true cleft. A soft tissue furrow radiates superiorly and posterisphenoid is symmetric and normal. Mild cranial base asymmetry is reflected in the pterygoid plates. The left pair is more laterally displaced from the midline. Skull vault plagiocephaly is evident with an apparent reduction in the anteroposterior dimension of the anterior cranial fossa.		hp.json		http://purl.obolibrary.org/obo/HP_0031581		
GO:0046883	biolink:BiologicalProcess	regulation of hormone secretion	Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0046883		
HP:0031582	biolink:PhenotypicFeature	Tessier number 10 facial cleft	In a Number 10 Tessier cleft there is an upper central orbital cleft with a cleft of the middle one-third of the upper eyelid, which often results in total ablepharia. The eyebrow is disrupted, being virtually absent medially, whereas the lateral portion angles upward toward the frontal hairline. There may be ocular anomalies, including colobomata of the iris. The skeletal cleft is through the midportion of the supraorbital rim, the adjacent frontal bone, and the orbital roof lateral to the supraorbital nerve. A frontal encephalocele frequently occupies the frontal bony cleft. The palpebral fissure is grossly elongated with an amblyopic eye displaced inferiorly and laterally. There is also a divergent squint of the right eye. The eyebrow is deficient medially and becomes thinned out laterally , where it is contiguous with a broad downward and forward projection of the frontotemporal hairline (this may be seen in both the Number 9 and 10 clefts.) A broad frontal encephalocele bulges forward from the middle one-third of the right forehead, supraorbital ridge, and orbital roof. The bony cleft, through which the frontal encephalocele presents, involves the anterior half of the orbital roof, the supraorbital rim, and two-thirds of the vertical height of the frontal bone lateral to the supraorbital nerve. The bony orbit is inferiorly displaced and widened with the lateral orbital wall shortened and laterally deviated. Similar distortion of the anterior cranial fossa is evident, being broader and more flattened on the affected side. The calvarium above the level of the cleft and the cranial base below is symmetric.		hp.json		http://purl.obolibrary.org/obo/HP_0031582		
HP:0031583	biolink:PhenotypicFeature	Tessier number 11 facial cleft	An upper medial orbital cleft produces a cleft of the medial one-third of the upper eyelid that extends through the eyebrow into the frontal hairline. The skeletal element of the cleft in the region of the frontal process of the maxilla may either pass lateral to the ethmoid, through the supraorbital rim, or it may pass through the ethmoidal labyrinth to produce orbital hypertelorism. This cleft usually accompanies the Number 3 cleft. The soft tissue features include a cleft of the medial portion of the upper eyelid, an irregularity in hair orientation at the medial end of the eyebrow, and a long tongue-like projection of the frontal hairline onto the forehead. There is a mild flattening of the frontal process of the maxilla and extensive pneumatization of both the ethmoidal and frontal sinuses, both of which are more prominent on the cleft side. No bony clefting of the supraorbital rim or frontal bone is evident. The cranial base and sphenoid architecture, including the pterygoid processes, are symmetric and normal.		hp.json		http://purl.obolibrary.org/obo/HP_0031583		
GO:0010847	biolink:BiologicalProcess	regulation of chromatin assembly	Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus.		hp.json		http://purl.obolibrary.org/obo/GO_0010847		
CHEBI:35695	biolink:ChemicalSubstance	dicarboxylic acid monoanion	Any dicarboxylic acid anion that is a monoanion obtained by the deprotonation of only one of the carboxy groups of the dicarboxylic acid.		hp.json	dicarboxylic acid monoanions	http://purl.obolibrary.org/obo/CHEBI_35695		3_STAR
HP:0031588	biolink:PhenotypicFeature	Unhappy demeanor	A conspicuously unhappy disposition characterized by negative assumptions, self-defeating talk, fear of failure, and negative ruminations about past events.		hp.json	Unhappy demeanour	http://purl.obolibrary.org/obo/HP_0031588		
HP:0031589	biolink:PhenotypicFeature	Suicidal ideation	Frequent thinking about or preoccupation with killing oneself.		hp.json	Suicidality	http://purl.obolibrary.org/obo/HP_0031589		
GO:0046889	biolink:BiologicalProcess	positive regulation of lipid biosynthetic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.		hp.json	positive regulation of lipogenesis|positive regulation of lipid biosynthesis|positive regulation of lipid synthesis|up regulation of lipid biosynthetic process|positive regulation of lipid formation|stimulation of lipid biosynthetic process|up-regulation of lipid biosynthetic process|activation of lipid biosynthetic process|positive regulation of lipid anabolism|upregulation of lipid biosynthetic process	http://purl.obolibrary.org/obo/GO_0046889		
UBERON:0004622	biolink:AnatomicalEntity	sacral vertebra 1		FMA:13077|MA:0001434|EMAPA:19588|NCIT:C33498|UMLS:C0223598	hp.json	first sacral segment|first sacral vertebra|first segment of sacrum|S1 vertebra	http://purl.obolibrary.org/obo/UBERON_0004622		defined_by_ordinal_series
CHEBI:35692	biolink:ChemicalSubstance	dicarboxylic acid	Any carboxylic acid containing two carboxy groups.	KEGG:C02028	hp.json	Dicarboxylic acid|dicarboxylic acids	http://purl.obolibrary.org/obo/CHEBI_35692		3_STAR
UBERON:0004620	biolink:AnatomicalEntity	lumbar vertebra 4	The fourth lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	FMA:13075|MA:0001431|EMAPA:19572|NCIT:C32902|UMLS:C0223537	hp.json	fourth lumbar vertebra|L4 vertebra	http://purl.obolibrary.org/obo/UBERON_0004620		defined_by_ordinal_series
GO:0071840	biolink:BiologicalProcess	cellular component organization or biogenesis	A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.		hp.json	cellular component organisation or biogenesis|cellular component organisation or biogenesis at cellular level|cellular component organization or biogenesis at cellular level	http://purl.obolibrary.org/obo/GO_0071840		goslim_metagenomics|goslim_flybase_ribbon
UBERON:0004621	biolink:AnatomicalEntity	lumbar vertebra 5	The fifth lumbar vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	FMA:13076|MA:0001432|UMLS:C0223552|EMAPA:19573|NCIT:C32903	hp.json	fifth lumbar vertebra|L5 vertebra	http://purl.obolibrary.org/obo/UBERON_0004621		pheno_slim|defined_by_ordinal_series
CHEBI:35693	biolink:ChemicalSubstance	dicarboxylic acid anion			hp.json	dicarboxylic acid anion|dicarboxylic acid anions	http://purl.obolibrary.org/obo/CHEBI_35693		3_STAR
GO:0046890	biolink:BiologicalProcess	regulation of lipid biosynthetic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.		hp.json	regulation of lipid anabolism|regulation of lipogenesis|regulation of lipid biosynthesis|regulation of lipid synthesis|regulation of lipid formation	http://purl.obolibrary.org/obo/GO_0046890		
HP:0031590	biolink:PhenotypicFeature	Asthenopia	Eye strain, i.e., a feeling of fatigue or discomfort of the eyes related to 'overuse' of the eyes in activities such as reading or working at the computer and often accompanied by lacrimation or headache.		hp.json	Eye strain	http://purl.obolibrary.org/obo/HP_0031590		
HP:0031595	biolink:PhenotypicFeature	Abnormal P wave	Any anomaly of the P wave of the EKG, which results from atrial depolarization. The P wave occurs when the sinoatrial node creates an action potential that depolarizes the atria.		hp.json		http://purl.obolibrary.org/obo/HP_0031595		
GO:0044237	biolink:BiologicalProcess	cellular metabolic process	The chemical reactions and pathways by which individual cells transform chemical substances.		hp.json	intermediary metabolism|cellular metabolism	http://purl.obolibrary.org/obo/GO_0044237		gocheck_do_not_annotate
HP:0031596	biolink:PhenotypicFeature	Abnormal PR segment	An anomaly of the PR segment, which begins at the endpoint of the P wave and ends at the onset of the QRS complex. The PR segment is normally flat and isoelectric.		hp.json		http://purl.obolibrary.org/obo/HP_0031596		
HP:0031597	biolink:PhenotypicFeature	PR segment elevation	An increase in voltage of the PR segment above baseline.		hp.json	PTa elevation|PR interval elevation	http://purl.obolibrary.org/obo/HP_0031597		
HP:0031598	biolink:PhenotypicFeature	Notched P wave	V-shaped cut (notch) in the middle of the P wave.		hp.json		http://purl.obolibrary.org/obo/HP_0031598		
HP:0031591	biolink:PhenotypicFeature	Enlarged Eustachian valve	An abnormally large Eustachian valve (postnatally). The Eustachian valve is also known as the valve of the inferior vena cava, and is an embryologic remnant of the valve of the inferior vena cava.		hp.json	Enlarged inferior vena cava valve|Giant Eustachian valve	http://purl.obolibrary.org/obo/HP_0031591		
HP:0031592	biolink:PhenotypicFeature	Situs inversus with levocardia	Situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia.		hp.json		http://purl.obolibrary.org/obo/HP_0031592		
HP:0031593	biolink:PhenotypicFeature	Abnormal PR interval	An anomaly of the PR interval, which is the portion of the ECG from the onset of the P wave to the beginning of the QRS complex. A normal PR interval in adults is 0.12-0.2 seconds.		hp.json		http://purl.obolibrary.org/obo/HP_0031593		
HP:0031594	biolink:PhenotypicFeature	PR segment depression	A reduction in voltage of the PR segment below baseline.		hp.json	PTa depression|PR interval depression	http://purl.obolibrary.org/obo/HP_0031594		
GO:0140096	biolink:MolecularActivity	catalytic activity, acting on a protein	Catalytic activity that acts to modify a protein.		hp.json		http://purl.obolibrary.org/obo/GO_0140096		goslim_generic
GO:0140098	biolink:MolecularActivity	catalytic activity, acting on RNA	Catalytic activity that acts to modify RNA, driven by ATP hydrolysis.		hp.json		http://purl.obolibrary.org/obo/GO_0140098		goslim_generic
HP:0031599	biolink:PhenotypicFeature	P mitrale	A broad (120 ms or longer in duration) and bifid P-wave in EKG lead II.		hp.json		http://purl.obolibrary.org/obo/HP_0031599		
GO:0044238	biolink:BiologicalProcess	primary metabolic process	The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.		hp.json	primary metabolism	http://purl.obolibrary.org/obo/GO_0044238		goslim_pir
UBERON:0004613	biolink:AnatomicalEntity	mammalian cervical vertebra 4	The fourth of the seven cervical vertebrae[ncit,modified].	UMLS:C0459941|MA:0001424|EMAPA:19434|NCIT:C32242|FMA:12522	hp.json	C4 vertebra|fourth cervical vertebra|cervical vertebra 4	http://purl.obolibrary.org/obo/UBERON_0004613		defined_by_ordinal_series|pheno_slim
UBERON:0004614	biolink:AnatomicalEntity	mammalian cervical vertebra 5	The fifth of the seven cervical vertebrae[ncit,modified].	MA:0001425|EMAPA:19435|NCIT:C32243|FMA:12523|UMLS:C0459943	hp.json	cervical vertebra 5|C5 vertebra|fifth cervical vertebra	http://purl.obolibrary.org/obo/UBERON_0004614		defined_by_ordinal_series|pheno_slim
UBERON:0004611	biolink:AnatomicalEntity	rib 12	In humans: The twelfth rib has a single articular facet on the head, which is of rather large size. It has no necks or tubercles, and is pointed at its anterior ends. The twelfth has angle nor costal groove; it is much shorter than the eleventh rib, and its head is inclined slightly downward. Sometimes the twelfth rib is even shorter than the first rib. [WP,unvetted].	UMLS:C1709948|MA:0001412|EMAPA:19540|NCIT:C52767|FMA:8515	hp.json	costa XII|twelfth rib	http://purl.obolibrary.org/obo/UBERON_0004611		defined_by_ordinal_series|pheno_slim
UBERON:0004612	biolink:AnatomicalEntity	mammalian cervical vertebra 3	The third of the seven cervical vertebrae[ncit,modified].	MA:0001423|EMAPA:19433|UMLS:C0459939|NCIT:C32241|FMA:12521	hp.json	third cervical vertebra of axial skeleton|C3 vertebra|cervical vertebra 3|third cervical vertebra|cervical vertebrae 3	http://purl.obolibrary.org/obo/UBERON_0004612		defined_by_ordinal_series|pheno_slim
GO:0010828	biolink:BiologicalProcess	positive regulation of glucose transmembrane transport	Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	positive regulation of glucose transport	http://purl.obolibrary.org/obo/GO_0010828		
GO:0010829	biolink:BiologicalProcess	negative regulation of glucose transmembrane transport	Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	negative regulation of glucose transport	http://purl.obolibrary.org/obo/GO_0010829		
CHEBI:33019	biolink:ChemicalSubstance	diphosphate(3-)	A trivalent inorganic anion obtained by removal of all three protons from diphosphoric acid.	Beilstein:185088	hp.json	hydrogen diphosphate|HP2O7(3-)|diphosphate	http://purl.obolibrary.org/obo/CHEBI_33019		3_STAR
GO:0010822	biolink:BiologicalProcess	positive regulation of mitochondrion organization	Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.		hp.json	positive regulation of mitochondrion organisation	http://purl.obolibrary.org/obo/GO_0010822		
GO:0044247	biolink:NamedThing	cellular polysaccharide catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0044247		
GO:0044248	biolink:BiologicalProcess	cellular catabolic process	The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.		hp.json	cellular catabolism|cellular degradation|cellular breakdown	http://purl.obolibrary.org/obo/GO_0044248		
GO:0010823	biolink:BiologicalProcess	negative regulation of mitochondrion organization	Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.		hp.json	negative regulation of mitochondrion organisation	http://purl.obolibrary.org/obo/GO_0010823		
GO:0010820	biolink:BiologicalProcess	positive regulation of T cell chemotaxis	Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0010820		
PR:P10810	biolink:Protein	monocyte differentiation antigen CD14 (mouse)	A CD14 molecule that is encoded in the genome of mouse.	UniProtKB:P10810	hp.json	mCD14|myeloid cell-specific leucine-rich glycoprotein (mouse)|CD14 (mouse)|Cd14	http://purl.obolibrary.org/obo/PR_P10810		
GO:0010821	biolink:BiologicalProcess	regulation of mitochondrion organization	Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.		hp.json	regulation of mitochondrion organisation	http://purl.obolibrary.org/obo/GO_0010821		
GO:0010827	biolink:BiologicalProcess	regulation of glucose transmembrane transport	Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	regulation of glucose transport	http://purl.obolibrary.org/obo/GO_0010827		
CHEBI:23690	biolink:ChemicalSubstance	dicarboxylic acid amide			hp.json	dicarboxylic acid amides	http://purl.obolibrary.org/obo/CHEBI_23690		3_STAR
GO:0071869	biolink:BiologicalProcess	response to catecholamine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.		hp.json	response to catecholamine stimulus	http://purl.obolibrary.org/obo/GO_0071869		
CHEBI:33017	biolink:ChemicalSubstance	diphosphate(1-)	A monovalent inorganic anion obtained by deprotonation of one of the phosphate OH groups in diphosphoric acid.	Gmelin:185086	hp.json	trihydrogen diphosphate|H3P2O7(-)	http://purl.obolibrary.org/obo/CHEBI_33017		3_STAR
GO:0071868	biolink:BiologicalProcess	cellular response to monoamine stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.		hp.json		http://purl.obolibrary.org/obo/GO_0071868		
GO:0044249	biolink:BiologicalProcess	cellular biosynthetic process	The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.		hp.json	cellular biosynthesis|cellular anabolism|cellular synthesis|cellular formation	http://purl.obolibrary.org/obo/GO_0044249		
CHEBI:35679	biolink:ChemicalSubstance	antilipemic drug	A substance used to treat hyperlipidemia (an excess of lipids in the blood).	Wikipedia:Hypolipidemic_agent	hp.json	antihyperlipidemic drugs|antihyperlipidemic agents|antihyperlipemics|antilipemic drugs|antihyperlipidemic|lipid-lowering agent|hypolipidemic agent|antihyperlipidaemic agent|antilipemic|lipid-lowering drugs|antihyperlipidaemic drugs|antihyperlipidaemic drug|antilipemics|lipid-lowering drug|antihyperlipidaemic agents|lipid-lowering agents|hypolipidemic agents|antihyperlipidemics|antihyperlipemic|antihyperlipidemic agent|antihyperlipidemic drug	http://purl.obolibrary.org/obo/CHEBI_35679		3_STAR
GO:0071867	biolink:BiologicalProcess	response to monoamine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monoamine stimulus. A monoamine is any of a group of molecular messengers that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan.		hp.json	response to monoamine stimulus	http://purl.obolibrary.org/obo/GO_0071867		
UBERON:0004601	biolink:AnatomicalEntity	rib 1	The first rib of the rib cage.	MA:0001401|FMA:7597|NCIT:C52770|UMLS:C1709945|EMAPA:19529	hp.json	first rib|costa I|costa prima (I)|costa prima [I]|costa prima	http://purl.obolibrary.org/obo/UBERON_0004601		defined_by_ordinal_series|pheno_slim
NBO:0000086	biolink:NamedThing	novelty response behavior	"Behavior related to the exploration/investigation of a novel object, situation or environment." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000086		
CHEBI:59644	biolink:ChemicalSubstance	oxo fatty acid	Any fatty acid containing at least one aldehydic or ketonic group in addition to the carboxylic acid group.	PMID:8454196|PMID:6434570|PMID:8638935	hp.json	oxo fatty acids	http://purl.obolibrary.org/obo/CHEBI_59644		3_STAR
NBO:0000085	biolink:NamedThing	depression behavior	"Emotional behavior related to a state of low mood  and aversion to activity." [wikipedia:Depression]		hp.json	depression related behaviour	http://purl.obolibrary.org/obo/NBO_0000085		
GO:0010839	biolink:BiologicalProcess	negative regulation of keratinocyte proliferation	Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0010839		
GO:0010831	biolink:BiologicalProcess	positive regulation of myotube differentiation	Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.		hp.json		http://purl.obolibrary.org/obo/GO_0010831		
GO:0010832	biolink:BiologicalProcess	negative regulation of myotube differentiation	Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.		hp.json		http://purl.obolibrary.org/obo/GO_0010832		
GO:0010837	biolink:BiologicalProcess	regulation of keratinocyte proliferation	Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0010837		
GO:0010838	biolink:BiologicalProcess	positive regulation of keratinocyte proliferation	Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.		hp.json		http://purl.obolibrary.org/obo/GO_0010838		
GO:0044255	biolink:BiologicalProcess	cellular lipid metabolic process	The chemical reactions and pathways involving lipids, as carried out by individual cells.		hp.json	cellular lipid metabolism	http://purl.obolibrary.org/obo/GO_0044255		goslim_pir
NBO:0000094	biolink:NamedThing	fear behavior towards situation/environment	"An emotional behavior related to a feeling of uneasiness or nervousness in respect to a particular situation or environment." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000094		
NBO:0000092	biolink:NamedThing	anxiety-related behavior	"An emotional behavior related to a feeling of uneasiness or nervousness triggered by an identifiable triggering stimulus." [NBO:GVG]		hp.json	anxiety-related behaviour	http://purl.obolibrary.org/obo/NBO_0000092		
NBO:0000091	biolink:NamedThing	fear-related behavior	"An emotional behavior related to a feeling of uneasiness or nervousness triggered by a specified triggering stimulus such as pain or the threat of danger." [NBO:GVG]		hp.json	fear-related behaviour	http://purl.obolibrary.org/obo/NBO_0000091		
GO:0010830	biolink:BiologicalProcess	regulation of myotube differentiation	Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.		hp.json		http://purl.obolibrary.org/obo/GO_0010830		
CHEBI:35681	biolink:ChemicalSubstance	secondary alcohol	A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.	KEGG:C01612|KEGG:C00432	hp.json	a secondary alcohol|secondary alcohols|R-CHOH-R'|Secondary alcohol	http://purl.obolibrary.org/obo/CHEBI_35681		3_STAR
NBO:0000097	biolink:NamedThing	response to novel environment	"Behavior related to the exploration/investigation of a novel environment." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000097		
NBO:0000096	biolink:NamedThing	agoraphobia behavior	"A phobia characterised by fear of open spaces." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000096		
HP:0031540	biolink:PhenotypicFeature	Linear IgG deposits along the epidermal basement membrane zone	Presence of IgG antibodies in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy.		hp.json		http://purl.obolibrary.org/obo/HP_0031540		
HP:0031541	biolink:PhenotypicFeature	Linear C3 deposits along the epidermal basement membrane zone	Presence of complement C3 in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy.		hp.json		http://purl.obolibrary.org/obo/HP_0031541		
HP:0031542	biolink:PhenotypicFeature	Myelin-like whorls in vacuolated fibers	Muscle fibers contain one or more vacuoles (membrane-bound cavity) associated with collections of membranes arranged in a whorl-like (spiral or circular) manner.		hp.json	Myelin-like whorls in vacuolated fibres	http://purl.obolibrary.org/obo/HP_0031542		
GO:0032272	biolink:BiologicalProcess	negative regulation of protein polymerization	Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.		hp.json	inhibition of protein polymerization|down-regulation of protein polymerization|downregulation of protein polymerization|down regulation of protein polymerization	http://purl.obolibrary.org/obo/GO_0032272		
HP:0031548	biolink:PhenotypicFeature	Follicular infundibulum tumor	A cutaneous adnexal neoplasm with variable clinical presentation. It tends to be located in the head and neck and the presentation is papulonodular, scaly, asymptomatic, measuring up to 1-2cm, simulating a basal cell carcinoma.		hp.json	Basal cell hamartoma with follicular differentiation|Follicular infundibulum tumour	http://purl.obolibrary.org/obo/HP_0031548		
HP:0031549	biolink:PhenotypicFeature	Lymphocytoma cutis	Lymphocytoma cutis, or Spiegler-Fendt sarcoid, is classed as one of the pseudolymphomas, referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas. Careful clinical evaluation, histopathological and immunohistochemical exams may be needed to make the correct diagnosis.		hp.json	Spiegler-Fendt sarcoid|Skin pseudolymphoma	http://purl.obolibrary.org/obo/HP_0031549		
GO:0032271	biolink:BiologicalProcess	regulation of protein polymerization	Any process that modulates the frequency, rate or extent of the process of creating protein polymers.		hp.json	regulation of protein polymerisation	http://purl.obolibrary.org/obo/GO_0032271		
GO:0032270	biolink:BiologicalProcess	positive regulation of cellular protein metabolic process	Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.		hp.json	positive regulation of cellular protein metabolism|upregulation of cellular protein metabolic process|up regulation of cellular protein metabolic process|stimulation of cellular protein metabolic process|up-regulation of cellular protein metabolic process|activation of cellular protein metabolic process	http://purl.obolibrary.org/obo/GO_0032270		
HP:0006577	biolink:PhenotypicFeature	Macronodular cirrhosis	A type of cirrhosis characterized by the presence of large regenerative nodules.	UMLS:C2004456|SNOMEDCT_US:86454000|SNOMEDCT_US:43904005	hp.json		http://purl.obolibrary.org/obo/HP_0006577		
HP:0031544	biolink:PhenotypicFeature	Elevated circulating palmitoleylcarnitine concentration	An elevated level of propionylcarnitine in the circulation. Propionylcarnitine is present in high abundance in the urine of patients with Methylmalonyl-CoA mutase (MUT) deficiency.		hp.json	Elevated plasma palmitoleylcarnitine, C16:1|Elevated plasma propionylcarnitine, C3:0|Elevated circulating O-propionylcarnitine concentration|Elevated propionylcarnitine level	http://purl.obolibrary.org/obo/HP_0031544		
HP:0031545	biolink:PhenotypicFeature	Abnormally low T cell receptor excision circle level	Reduced level of T cell receptor excision circle (TRECs) as measured by the TREC assay. Late in maturation, 70% of thymocytes that will ultimately express alpha/beta-T cell receptors form a circular DNA TREC from the excised TCRdelta gene that lies within the TCRalpha genetic locus. The circles are stable but do not increase following cell division and, therefore, become diluted as T cells proliferate. A quantitative polymerase chain reaction (PCR) reaction across the joint of the circular DNA provides the TREC copy number, a marker of newly-formed, antigenically-naïve thymic emigrant T cells.		hp.json		http://purl.obolibrary.org/obo/HP_0031545		
HP:0031546	biolink:PhenotypicFeature	Cardiac conduction abnormality	Any anomaly of the progression of electrical impulses through the heart.		hp.json	Abnormality of cardiac conduction system|Heart conduction disorder|Cardiac conduction abnormalities|Cardiac conduction defects|Abnormality of cardiac conduction	http://purl.obolibrary.org/obo/HP_0031546		
HP:0006579	biolink:PhenotypicFeature	Prolonged neonatal jaundice	Neonatal jaundice refers to a yellowing of the skin and other tissues of a newborn infant as a result of increased concentrations of bilirubin in the blood. Neonatal jaundice affects over half of all newborns to some extent in the first week of life. Prolonged neonatal jaundice is said to be present if the jaundice persists for longer than 14 days in term infants and 21 days in preterm infants.	SNOMEDCT_US:387712008|MSH:D007567|UMLS:C0022353|UMLS:C1859236	hp.json	Jaundice, neonatal|Prolonged yellowing of skin in newborn|Neonatal jaundice	http://purl.obolibrary.org/obo/HP_0006579		
HP:0031547	biolink:PhenotypicFeature	Abnormal QT interval	Any anomaly of the time interval between the start of the Q wave and the end of the T wave as measured by the electrocardiogram (EKG).		hp.json		http://purl.obolibrary.org/obo/HP_0031547		
HP:0006573	biolink:PhenotypicFeature	Acute hepatic steatosis	An acute form of hepatic steatosis.	UMLS:C4025020	hp.json	Acute fatty liver	http://purl.obolibrary.org/obo/HP_0006573		
HP:0006574	biolink:PhenotypicFeature	Hepatic arteriovenous malformation		SNOMEDCT_US:84150000|UMLS:C0520557	hp.json	Liver arteriovenous malformation	http://purl.obolibrary.org/obo/HP_0006574		
HP:0006575	biolink:PhenotypicFeature	Intrahepatic cholestasis with episodic jaundice		UMLS:C4025019	hp.json		http://purl.obolibrary.org/obo/HP_0006575		
HP:0006576	biolink:PhenotypicFeature	Hepatic vascular malformations		UMLS:C1861790	hp.json	Liver vascular malformations	http://purl.obolibrary.org/obo/HP_0006576		
HP:0006571	biolink:PhenotypicFeature	Reduced number of intrahepatic bile ducts	The presence of reduced numbers of intrahepatic bile duct than normal.	UMLS:C4021591|UMLS:C1861621	hp.json	Intrahepatic duct deficiency|Hepatic ductopenia	http://purl.obolibrary.org/obo/HP_0006571		
GO:0032273	biolink:BiologicalProcess	positive regulation of protein polymerization	Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.		hp.json	upregulation of protein polymerization|up regulation of protein polymerization|stimulation of protein polymerization|up-regulation of protein polymerization|activation of protein polymerization	http://purl.obolibrary.org/obo/GO_0032273		
HP:0006572	biolink:PhenotypicFeature	Subacute progressive viral hepatitis		UMLS:C1861901	hp.json		http://purl.obolibrary.org/obo/HP_0006572		
HP:0006590	biolink:PhenotypicFeature	Premature sternal synostosis	Prematurely closed sternal sutures.	UMLS:C4021590	hp.json	Prematurely closed sternal sutures	http://purl.obolibrary.org/obo/HP_0006590		
HP:0031551	biolink:PhenotypicFeature	Reduced cell surface marker level	Reduced level of a protein that is normally present on the cell surface as assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031551		
HP:0031552	biolink:PhenotypicFeature	Reduced fibroblast surface marker level	Reduced level of a protein that is normally present on the fibroblast surface as assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031552		
HP:0031553	biolink:PhenotypicFeature	Reduced granulocyte surface marker level	Reduced level of a protein that is normally present on the granulocyte surface as assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031553		
HP:0031554	biolink:PhenotypicFeature	Reduced granulocyte CD55 level	Reduced level of CD55 on the granulocyte surface as assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031554		
HP:0031550	biolink:PhenotypicFeature	Abnormal flow cytometry test result	Any abnormal result of flow cytometry, a method that suspends cells in a stream of fluid and passes them through an electronic detection apparatus in order to assess cell count or measure biomarkers or surface molecules.		hp.json		http://purl.obolibrary.org/obo/HP_0031550		
HP:0031559	biolink:PhenotypicFeature	Reduced fibroblast CD16 level	Reduced level of CD16 on the fibroblast surface as assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031559		
HP:0031555	biolink:PhenotypicFeature	Reduced granulocyte CD59 level	Reduced level of CD59 on the granulocyte surface as assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031555		
HP:0006589	biolink:PhenotypicFeature	Flaring of lower rib cage		UMLS:C1855196	hp.json	Flaring of lower rib cage	http://purl.obolibrary.org/obo/HP_0006589		
HP:0031556	biolink:PhenotypicFeature	Reduced granulocyte CD16 level	Reduced level of CD16 on the granulocyte surface as assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031556		
HP:0031557	biolink:PhenotypicFeature	Reduced fibroblast CD55 level	Reduced level of CD55 on the fibroblast surface as assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031557		
HP:0031558	biolink:PhenotypicFeature	Reduced fibroblast CD59 level	Reduced level of CD59 on the fibroblast surface as assessed by flow cytometry.		hp.json		http://purl.obolibrary.org/obo/HP_0031558		
HP:0006584	biolink:PhenotypicFeature	Small abnormally formed scapulae		UMLS:C1861226	hp.json	Small abnormally formed scapula|Small abnormally formed shoulder blade	http://purl.obolibrary.org/obo/HP_0006584		
GO:0032269	biolink:BiologicalProcess	negative regulation of cellular protein metabolic process	Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.		hp.json	downregulation of cellular protein metabolic process|down regulation of cellular protein metabolic process|inhibition of cellular protein metabolic process|down-regulation of cellular protein metabolic process|negative regulation of cellular protein metabolism	http://purl.obolibrary.org/obo/GO_0032269		
HP:0006585	biolink:PhenotypicFeature	Congenital pseudoarthrosis of the clavicle	The two portions of the clavicle (corresponding to the two primary ossification centers of the clavicle) are connected by a fibrous bridge that is contiguous with the periosteum, and a synovial membrane develops, resulting in a clavicle with a bipartite appearance radiographically. Congenital pseudarthrosis of the clavicle generally presents as a painless mass or swelling over the clavicle.	UMLS:C0426811|SNOMEDCT_US:249690001|SNOMEDCT_US:249685004|UMLS:C0426806	hp.json	Pseudoarthrosis of clavicle|Clavicle pseudoarthrosis|Bipartite clavicle	http://purl.obolibrary.org/obo/HP_0006585		
GO:0032268	biolink:BiologicalProcess	regulation of cellular protein metabolic process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.		hp.json	regulation of cellular protein metabolism	http://purl.obolibrary.org/obo/GO_0032268		
HP:0006587	biolink:PhenotypicFeature	Straight clavicles	An abnormally straight configuration of the clavicle, a tubular bone which normally is doubly curved .	UMLS:C4025016	hp.json	Straight collarbone	http://purl.obolibrary.org/obo/HP_0006587		
HP:0006580	biolink:PhenotypicFeature	Portal fibrosis	Fibroblast proliferation and fiber expansion from the portal areas to the lobule.	UMLS:C2677002|UMLS:C3805083	hp.json	Portal fibrosis shown on biopsy	http://purl.obolibrary.org/obo/HP_0006580		
HP:0006581	biolink:PhenotypicFeature	Depletion of mitochondrial DNA in liver	An abnormal reduction in the number of mitochondria in hepatocytes.	UMLS:C4025018	hp.json		http://purl.obolibrary.org/obo/HP_0006581		
HP:0006582	biolink:PhenotypicFeature	Reye syndrome-like episodes	Repeated occurrences of acute noninflammatory encephalopathy and fatty degenerative liver failure.	UMLS:C1850413	hp.json		http://purl.obolibrary.org/obo/HP_0006582		
HP:0006583	biolink:PhenotypicFeature	Fatal liver failure in infancy		UMLS:C4025017	hp.json	Fatal liver failure in infancy	http://purl.obolibrary.org/obo/HP_0006583		
HP:0031562	biolink:PhenotypicFeature	Balanced double aortic arch	A type of double aortic arch in which the two branches are of equal size. In most cases of double aortic arch, the right aortic arch is larger and located higher than the left aortic arch.	Fyler:2780	hp.json		http://purl.obolibrary.org/obo/HP_0031562		
HP:0031563	biolink:PhenotypicFeature	Coronary arteriovenous fistula	An abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering any segment of the systemic or pulmonary circulation.	Fyler:2240	hp.json		http://purl.obolibrary.org/obo/HP_0031563		
HP:0031564	biolink:PhenotypicFeature	Bronchial isomerism	An anomalous mirror-imaged arrangement of some bronchial structures. Right isomerism is defined as a subset of heterotaxy where some paired structures on opposite sides of the left-right axis of the body are symmetrical mirror images of each other, and have the morphology of the normal right-sided structures (vice versa for left isomerism).		hp.json		http://purl.obolibrary.org/obo/HP_0031564		
HP:0031565	biolink:PhenotypicFeature	Abdominal situs ambiguus	An abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements.	Fyler:3817	hp.json		http://purl.obolibrary.org/obo/HP_0031565		
HP:0031560	biolink:PhenotypicFeature	Coronary cameral fistula	An abnormal communication between coronary artery and a cardiac chamber.	Fyler:2233	hp.json		http://purl.obolibrary.org/obo/HP_0031560		
HP:0031561	biolink:PhenotypicFeature	Coronary cameral fistula to right ventricle	An abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering the right ventricle.		hp.json		http://purl.obolibrary.org/obo/HP_0031561		
HP:0006559	biolink:PhenotypicFeature	Hepatic calcification	The presence of abnormal calcium deposition in the liver.	UMLS:C1696466	hp.json	Liver calcifications	http://purl.obolibrary.org/obo/HP_0006559		
HP:0031566	biolink:PhenotypicFeature	Abnormal pulmonary valve cusp morphology	Any structural anomaly of the pulmonary valve leaflets.	Fyler:1652	hp.json		http://purl.obolibrary.org/obo/HP_0031566		
HP:0006555	biolink:PhenotypicFeature	Diffuse hepatic steatosis	A diffuse form of hepatic steatosis.	UMLS:C1849686	hp.json	Hepatic steatosis, diffuse	http://purl.obolibrary.org/obo/HP_0006555		
HP:0031567	biolink:PhenotypicFeature	Abnormal aortic valve cusp morphology	Any structural anomaly of the aortic valve leaflets.	Fyler:1480	hp.json		http://purl.obolibrary.org/obo/HP_0031567		
HP:0006557	biolink:PhenotypicFeature	Polycystic liver disease		SNOMEDCT_US:72925005|UMLS:C0158683|MSH:C536330	hp.json		http://purl.obolibrary.org/obo/HP_0006557		
HP:0031568	biolink:PhenotypicFeature	Thickened aortic valve cusp	An abnormally increased thickness of a leaflet of the aortic valve.	Fyler:1486	hp.json		http://purl.obolibrary.org/obo/HP_0031568		
HP:0031569	biolink:PhenotypicFeature	Absent aortic valve cusps	A developmental defect characterized by the lack of aortic valve cusps (leaflets). There may be remnants of the aortic valve in form of a nonobstructive fibrous ridge or rudimentary leaflets or sinuses of Valsalva.	Fyler:1484	hp.json	Absent aortic valve	http://purl.obolibrary.org/obo/HP_0031569		
HP:0006558	biolink:PhenotypicFeature	Decreased mitochondrial complex III activity in liver tissue	Decreased activity of complex III of the mitochondrion in the liver.	UMLS:C4025022	hp.json		http://purl.obolibrary.org/obo/HP_0006558		
HP:0006552	biolink:PhenotypicFeature	Fibrocystic lung disease		UMLS:C1397290	hp.json		http://purl.obolibrary.org/obo/HP_0006552		
HP:0006554	biolink:PhenotypicFeature	Acute hepatic failure	Hepatic failure refers to the inability of the liver to perform its normal synthetic and metabolic functions, which can result in coagulopathy and alteration in the mental status of a previously healthy individual. Hepatic failure is defined as acute if there is onset of encephalopathy within 8 weeks of the onset of symptoms in a patient with a previously healthy liver.	MSH:D017114|SNOMEDCT_US:197270009|SNOMEDCT_US:235884008|UMLS:C0162557	hp.json	Acute liver failure	http://purl.obolibrary.org/obo/HP_0006554		
GO:0032252	biolink:BiologicalProcess	secretory granule localization	Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.		hp.json	secretory granule clustering|secretory granule localisation	http://purl.obolibrary.org/obo/GO_0032252		
HP:0031573	biolink:PhenotypicFeature	Tessier number 2 facial cleft	As is typically seen in isolated cleft cases, a cleft of the lip is present. There is hypoplasia, but not true notching of the ala nasi with flattening of the lateral part of the nose. The nasal root is broadened, with lateral displacement of the inner canthus. The palpebral fissure and lacrimal drainage system are not disturbed. The alveolar cleft is through the lateral incisor area and extends to the pyriform aperture. There is normal septation between the nasal cavity and maxillary sinus. Notching at the junction between the nasal bone is present, as is a broad, flat frontal process of the maxilla. Transverse ethmoid enlargement produces orbital hypertelorism. Above the cleft of the lip and palate is a true broad cleft of the nostril that is medial to the intact, but laterally displaced, tail of the alar cartilage. A shallow soft tissue groove extends superiorly to the asymmetrically widened nasal root. The lacrimal system, palpebral fissures, and eyebrows remain intact. The alveolar cleft extends posteriorly as a complete unilateral cleft of the hard and soft palate. The nasal septum is intact but deviated to the opposite side. The nasal cavity remains separated from the normally pneumatized, although hypoplastic, maxilla on the cleft side. Above the nasomaxillary notching, the ethmoid sinus is less well developed, and there is no pneumatization of the frontal sinus on this side. Anterior rotation of the greater and lesser wings of the sphenoid occurs on the cleft side in relation to the narrower orbit and smaller ethmoid sinus. There is mild asymmetry of the anterior cranial fossa, which is narrower on the cleft side. The cranium is brachycephalic with marked occipital flattening.		hp.json		http://purl.obolibrary.org/obo/HP_0031573		
HP:0031574	biolink:PhenotypicFeature	Orbital cleft	A facial cleft characterized by involvement of the orbit.		hp.json		http://purl.obolibrary.org/obo/HP_0031574		
HP:0031575	biolink:PhenotypicFeature	Tessier number 3 facial cleft	As in the Number 1 and Number 2 clefts, this cleft extends through the lip in the region of the typical cleft lip; however, it does not extend through the base. The cleft continues superiorly to involve the inner canthus and lower eyelid medial to the inferior lacrimal punctum, thereby disrupting the nasolacrimal system. Microphthalmia may be present. The alveolar cleft is between the lateral incisor and the canine. Absent septation between the nasal cavity and maxillary antrum, together with the distortion of the frontal process of the maxilla and lacrimal fossa, produces direct communication between the orbit, maxillary sinus, and nose. There is hypoplasia of the soft tissue margins of the cleft in the vertical dimension. This produces extreme soft tissue deficiency between the alar base and the cleft of the medial aspect of the lower eyelid. The inferior lacrimal punctum is evident at the lateral margin of the lower eyelid cleft. The lacrimal drainage system ends as an opening directly onto the cheek without communication into the nasal cavity. The globe is normal in size, but it is displaced inferiorly and laterally. The nasal septum shows the characteristic distortion seen in typical cleft lip and palate. There is absence of septation between the nasal cavity on the cleft side and the maxilla. The maxilla is hypoplastic in three dimensions, with a marked reduction in pneumatization. Superior extension of the skeletal clefting into the medial portion of the orbital floor and into the inferior orbital rim in the region of the frontal process of the maxilla allows direct communication between the orbit above and the nasomaxillary region below. There is mild narrowing of the ethmoid sinus and of the body of the sphenoid on the cleft side. The pterygoid process appears anatomically normal, but less displaced from the midline compared with that of the noncleft side. Both the orbit and the floor of the anterior cranial fossa are inferiorly displaced.		hp.json		http://purl.obolibrary.org/obo/HP_0031575		
HP:0031576	biolink:PhenotypicFeature	Tessier number 4 facial cleft	The cleft lip is midway between the philtral ridge and the commissure of the mouth. The cleft is lateral to the normally shaped and placed nasal ala and passes onto the cheek. The cleft extends through the lower eyelid lateral to the punctum. The lacrimal system and inner canthus are normal. Microphthalmia may be present. The alveolar cleft passes between the lateral incisor and canine, as in the Number 3 cleft. The cleft passes around the pyriform aperture and continues through the portion of the maxillary sinus medial to the infraorbital foramen. The cleft terminates at the medial end of the inferior orbital rim. There is severe vertical soft tissue deficiency in a Number 4 cleft, with the medial margins of the cleft lip extending directly into the medially placed cleft of the lower eyelid. Within the medial segment of the right-sided cleft lip, muscle elements are apparently absent. Muscle bunching is noted in the ipsilateral lateral lip segment, as is seen in a typical unilateral cleft lip. The anatomically normal nasal ala is superiorly displaced in association with a severe deficiency in the overall nasal length. Marked dystopia of the right globe results in its inferior displacement into the medially deficient orbital floor and inferior rim. Both globes are otherwise normal. The complete palatal cleft passes through the maxilla medial to the infraorbital foramen and extends to the medial portion of the inferior orbital rim without evidence of an intact maxillary sinus. Bony septation persists medially, thereby separating the nasal cavity from the orbit, maxillary sinus, and mouth, which are contiguous. Marked midfacial hypoplasia is present. The cleft is manifest as asymmetry of the body of the sphenoid; it is smaller on the right, with asymmetric placement of the pterygoid plates relative to the midline. The orbital floor cleft has no communication with the inferior orbital fissure. The cleft does not extend to the skull base, but there is marked facial asymmetry associated with plagiocephaly.		hp.json		http://purl.obolibrary.org/obo/HP_0031576		
HP:0031570	biolink:PhenotypicFeature	Tessier number 0 facial cleft	A Number 0 Tessier cleft is a true median cleft lip with a broad columella and bifid nasal tip. The alveolar cleft is between the central incisors. The nasal septum may be thickened, duplicated, or absent. The nasal bridge is usually broad with associated orbital hypertelorism. The midline soft tissue anomaly may range from a mild broadening of the philtrum or there may be a true median cleft lip. The columella and nasal tip are typically bifid and broadened with a midline depression. The alae nasi are intact but laterally displaced. The nose appears shortened in the vertical dimension.		hp.json	Tessier facial cleft number 0	http://purl.obolibrary.org/obo/HP_0031570		
HP:0031571	biolink:PhenotypicFeature	Paramedian facial cleft	A type of facial cleft located near to but not directly on the midline of the face.		hp.json		http://purl.obolibrary.org/obo/HP_0031571		
HP:0031572	biolink:PhenotypicFeature	Tessier number 1 facial cleft	As seen in a typical cleft lip, a cleft of the lip is found in the region of the cupid's bow. The nostril is cleft through the alar dome and extends above onto the nasal dorsum. It passes medial to a normal, but dys- topic, medial canthus. There is an alveolar cleft between the central and lateral incisors that extends above through the pyriform margin lateral to the anterior nasal spine; the nasal septum is not involved. The bony cleft extends through the nasal bone or between the junction of the nasal bone and frontal process of the maxilla. Above the cleft lip, the clefting of the alar dome is associated with deviation to the opposite side of the shortened and broadened columella and nasal tip. Extension of the soft tissue cleft onto the nasal dorsum can be manifest as a series of vertical soft tissue furrows and ridges. Vertical inner canthal dysto- pia and severe telecanthus mark the superior aspect of the Number 1 facial cleft. A cranial soft tissue extension characterized by a tongue-like projection of the frontal hairline delineates the number 13 cleft. Skeletal clefting of the maxilla may extend posteriorly to form a complete cleft of the hard and soft palate. The maxilla is hypoplastic in all three dimensions. There is a keel-shaped alveolus and anterior open bite. Normal septation is preserved between the nasal cavity and the hypoplastic maxillary antrum on the affected side. Distortion of the nasal skeleton produces gross flattening of the nasal dorsum. There is asymmetry of the pterygoid plates, of the greater and lesser wings of the sphenoid, and of the floor of the anterior cranial fossa. The distortion of the cranial base may result in a mild plagiocephaly.		hp.json		http://purl.obolibrary.org/obo/HP_0031572		
HP:0031577	biolink:PhenotypicFeature	Tessier number 5 facial cleft	The cleft of the lip is just medial to the oral commissure and extends across the cheek as a furrow. It ends as a cleft at the junction of the middle and lateral third of the lower eyelid. Microphthalmia is frequently present. The alveolar cleft is through the premolar region and extends superiorly through the orbit at the inferolateral part of the rim and floor. There is a vertical soft tissue deficiency between the lateral portion of the lip and the lower eyelid cleft. The left side of the nose shows vertical shortening, and the left alar base is displaced superiorly. Facial asymmetry secondary to the skeletal abnormality is reflected by a vertical orbital dystopia. However, bothglobes are normal, and there is no abnormality of the upper eyelids, eyebrow, forehead, or frontal hairline. The skeletal clefts vary, ranging from a narrow skeletal furrow that traverses the anterior maxillary wall as on the rightto a broad cleft of the maxilla lateral to the infraorbital foramen and maxillary sinus. This latter cleft enters the inferolateral orbital rim and floor without posterior communication with the inferior orbital fissure on the left side. Medial collapse of the lateral maxillary segments is present bilaterally, with reduction in the transverse dimensions of the maxillary arch. Manifestations of the skeletal disturbance in the sphenoid include a shortening and thickening of the lateral orbital walls in the region of the greater wing and mild asymmetric placement of the pterygoid plates relative to the midline. The right-sided pterygoid plates are smaller and closer to the midline. There is minimal asymmetry of the cranial base and calvarium.		hp.json		http://purl.obolibrary.org/obo/HP_0031577		
HP:0006566	biolink:PhenotypicFeature	Neonatal cholestatic liver disease		UMLS:C1859162	hp.json		http://purl.obolibrary.org/obo/HP_0006566		
HP:0031578	biolink:PhenotypicFeature	Tessier number 6 facial cleft	A facial cleft extending from the zygomatic arch to the eye. This zygomaticomaxillary cleft is similar to that typically found in Treacher Collins syndrome. The overlying tissue shows a vertical sclerodermic furrow radiating from the labial commissure or the angle of the mandible across the cheek to a coloboma of the lower eyelid between the middle and lateral one-third. Microphthalmia is not observed. The skeletal cleft is between the maxilla and zygoma; it passes through the inferolateral orbital rim to enter the inferior orbital fissure. No alveolar cleft is present. The zygomatic arch is intact. The soft tissue furrow, which is more apparent on the right, radiates from the oral commissure toward the lateral two-thirds of the lower eyelid. The antimongoloid obliquity of the palpebral fissures is associated with laterally placed lower eyelid clefts and some ectropion. A left-sided anophthalmia is accompanied by adjacent soft tissue hypoplasia and is reflected in a short palpebral fissure, enophthalmos, and minor ptosis of the eyebrow. No abnormality is present in the alveolar arch except for some tilting of the occlusal plane secondary to hypoplasia of the left side of the maxilla. There is a vertical bony groove in the region of the zygomaticomaxillary suture that ends in the inferolateral portion of a small bony orbit. More laterally, the remainder of the zygomatic body and arch is normal in both shape and dimension. The lateral orbital floor is downslanting but intact, and it lacks direct communication with the temporal or infratemporal fossae. The hypoplasia of the left side of the maxilla and orbit is associated with a reduction in the transverse and anteroposterior dimensions of the anterior cranial fossa; mild asymmetry of the middle cranial fossa and calvarium is present. No significant asymmetry of size, shape, or position is present in the sphenoid.		hp.json	Tessier facial cleft number 6	http://purl.obolibrary.org/obo/HP_0031578		
HP:0006568	biolink:PhenotypicFeature	Increased hepatic glycogen content	An increase in the amount of glycogen stored in hepatocytes compared to normal.	UMLS:C1856285	hp.json	Increased liver glycogen content	http://purl.obolibrary.org/obo/HP_0006568		
HP:0031579	biolink:PhenotypicFeature	Tessier number 7 facial cleft	The temporozygomatic Number 7 cleft is found in both Treacher Collins syndrome and hemifacial microsomia. Soft tissue manifestations include macrostomia, malformations of the external and middle ear, temporalis muscle, variable involvement of the seventh cranial nerve (in hemifacial microsomia), and abnormalities of the preauricular hair in Treacher Collins syndrome. The skeletal cleft is through the pterygomaxillary junction, and vertical maxillary hypoplasia is present. In addition, abnormality of the mandibular ramus, coronoid, and condyle and absence of the zygomatic arch are typically present. A soft tissue furrow extends from the macrostomia laterally and superiorly across the cheek toward the preauricular hairline. The lower eyelids are intact. The anatomy of the external ear is normal, and there are no preauricular tags. Bony clefting is through the pterygomaxillary junction with hypoplasia of the alveolar process in the molar region, thereby producing a posterior open bite. The maxilla is hypoplastic, although the maxillary sinuses are symmetrically pneumatized. The hypoplastic zygomatic body arches upward, but then it takes a downward course and is severely malformed and displaced. The zygoma is continuous posteriorly with an apparently normal zygomatic process of the temporal bone. The mandibular condyle and coronoid process are hypoplastic and asymmetric. There is no antegonial notching of the mandible. Marked cranial base asymmetry, with tilting and asymmetric positioning of the temporomandibular articulations, is present. The anatomy of the sphenoid is abnormal, especially on the right where there is no recognizable medial or lateral pterygoid plate.		hp.json	Tessier cleft number 7|Tessier facial cleft number 7	http://purl.obolibrary.org/obo/HP_0031579		
HP:0006562	biolink:PhenotypicFeature	Viral hepatitis	Inflammation of the liver due to infection with a virus.	SNOMEDCT_US:3738000|UMLS:C0042721	hp.json		http://purl.obolibrary.org/obo/HP_0006562		
HP:0006563	biolink:PhenotypicFeature	Malformation of the hepatic ductal plate		UMLS:C1857519	hp.json		http://purl.obolibrary.org/obo/HP_0006563		
HP:0006564	biolink:PhenotypicFeature	Fluctuating hepatomegaly	Intermittently increased size of the liver.	UMLS:C1835881	hp.json		http://purl.obolibrary.org/obo/HP_0006564		
HP:0006565	biolink:PhenotypicFeature	Increased hepatocellular lipid droplets	An abnormal increase in the amount of intracellular lipid droplets in hepatocytes.	UMLS:C4025021	hp.json		http://purl.obolibrary.org/obo/HP_0006565		
GO:0032241	biolink:BiologicalProcess	positive regulation of nucleobase-containing compound transport	Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|activation of nucleobase, nucleoside, nucleotide and nucleic acid transport|stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport	http://purl.obolibrary.org/obo/GO_0032241		
HP:0006560	biolink:PhenotypicFeature	Biliary hyperplasia	Hyperplasia of the biliary tree, as manifested by increased size of bile ducts, dilated lumen, and histologically by an increased number of epithelial cells or hyperplasia.	UMLS:C3672440|UMLS:C3686778	hp.json	Bile duct hyperplasia	http://purl.obolibrary.org/obo/HP_0006560		
GO:0032240	biolink:BiologicalProcess	negative regulation of nucleobase-containing compound transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport|downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport|down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport	http://purl.obolibrary.org/obo/GO_0032240		
HP:0006561	biolink:PhenotypicFeature	Lipid accumulation in hepatocytes		UMLS:C1837257	hp.json		http://purl.obolibrary.org/obo/HP_0006561		
NBO:0000018	biolink:NamedThing	fear/anxiety related behavior	"Emotional behavior related to fear or anxiety." [NBO:GVG]		hp.json	fear/anxiety related behaviour	http://purl.obolibrary.org/obo/NBO_0000018		
GO:0032239	biolink:BiologicalProcess	regulation of nucleobase-containing compound transport	Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport	http://purl.obolibrary.org/obo/GO_0032239		
NBO:0000015	biolink:NamedThing	aggressive behavior	"A behavioral interaction between organisms in which one organism has the intention of inflicting damage on another individual using physical or verbal means." [wikipedia:Aggression]		hp.json	aggression|aggressive behaviour|agonism	http://purl.obolibrary.org/obo/NBO_0000015		
GO:0007276	biolink:BiologicalProcess	gamete generation	The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.		hp.json	gametogenesis	http://purl.obolibrary.org/obo/GO_0007276		
GO:0007275	biolink:BiologicalProcess	multicellular organism development	The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).		hp.json		http://purl.obolibrary.org/obo/GO_0007275		gocheck_do_not_annotate|goslim_plant|goslim_chembl
GO:0007274	biolink:BiologicalProcess	neuromuscular synaptic transmission	The process of synaptic transmission from a neuron to a muscle, across a synapse.		hp.json		http://purl.obolibrary.org/obo/GO_0007274		
GO:0007283	biolink:BiologicalProcess	spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.	Wikipedia:Spermatogenesis	hp.json	generation of spermatozoa	http://purl.obolibrary.org/obo/GO_0007283		
HP:0031504	biolink:PhenotypicFeature	Foamy urine	Urine has an increased amount of frothy fine bubbles.		hp.json	Frothy urine	http://purl.obolibrary.org/obo/HP_0031504		
HP:0031505	biolink:PhenotypicFeature	Abnormal circulating T4 concentration	A deviation from the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3).		hp.json	Abnormal circulating T4 level|Abnormal circulating thyroxine level	http://purl.obolibrary.org/obo/HP_0031505		
HP:0031506	biolink:PhenotypicFeature	Increased circulating T4 concentration	An elevation above the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3).		hp.json	Increased circulating thyroxine level|Increased circulating T4 level	http://purl.obolibrary.org/obo/HP_0031506		
GO:0007281	biolink:BiologicalProcess	germ cell development	The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.		hp.json	primordial germ cell development|germ-cell development	http://purl.obolibrary.org/obo/GO_0007281		
HP:0031507	biolink:PhenotypicFeature	Decreased circulating T4 concentration	A reduction below the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3).		hp.json	Reduced T4 plasma level|Decreased circulating T4 level|Decreased circulating thyroxine level	http://purl.obolibrary.org/obo/HP_0031507		
HP:0031500	biolink:PhenotypicFeature	Abdominal mass	An abnormal enlargement or swelling in the abdomen.		hp.json		http://purl.obolibrary.org/obo/HP_0031500		
HP:0031501	biolink:PhenotypicFeature	Pelvic mass	An abnormal enlargement or swelling in the pelvic region.		hp.json		http://purl.obolibrary.org/obo/HP_0031501		
HP:0031502	biolink:PhenotypicFeature	Trophoblastic tumor	A gestational or non-gestational neoplasm composed of neoplastic trophoblastic cells [NCIT:C3422].		hp.json	Trophoblastic tumour	http://purl.obolibrary.org/obo/HP_0031502		
HP:0031503	biolink:PhenotypicFeature	Night gasping	Waking up at night gasping for breath.		hp.json		http://purl.obolibrary.org/obo/HP_0031503		
NBO:0000024	biolink:NamedThing	sleeping behavior	"Behavior related to the readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000024		
HP:0031508	biolink:PhenotypicFeature	Abnormal circulating thyroid hormone concentration	Any deviation from the normal range of the hormones produced by the thyroid gland.		hp.json	Abnormal thyroid hormone level	http://purl.obolibrary.org/obo/HP_0031508		
HP:0031509	biolink:PhenotypicFeature	Dry nipple	Abnormally dry skin in the area of the nipple of the breast.		hp.json		http://purl.obolibrary.org/obo/HP_0031509		
HP:0031510	biolink:PhenotypicFeature	Linear earlobe crease	A transverse linear fissure (crease) in the lobule of the ear.		hp.json		http://purl.obolibrary.org/obo/HP_0031510		
GO:0007286	biolink:NamedThing	spermatid development			hp.json		http://purl.obolibrary.org/obo/GO_0007286		
HP:0031515	biolink:PhenotypicFeature	Abnormal meiosis	Any anomaly of meiosis, a type of cell division that reduces the number of chromosomes in the parent cell by half and produces four gamete cells.		hp.json		http://purl.obolibrary.org/obo/HP_0031515		
HP:0031516	biolink:PhenotypicFeature	Oocyte arrest at metaphase I	Failure of oocytes to proceed through the stages of meiosis with stoppage at the first metaphase stage.		hp.json	Metaphase I oocyte meiotic arrest|Oocyte meiotic arrest at metaphase I	http://purl.obolibrary.org/obo/HP_0031516		
GO:0007293	biolink:BiologicalProcess	germarium-derived egg chamber formation	Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.		hp.json		http://purl.obolibrary.org/obo/GO_0007293		
HP:0031517	biolink:PhenotypicFeature	Verruciform xanthoma	A papillary or cauliflower-like growth characterized by the presence of foamy histiocytes within the elongated dermal papillae forms.		hp.json		http://purl.obolibrary.org/obo/HP_0031517		
GO:0007292	biolink:BiologicalProcess	female gamete generation	Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.		hp.json		http://purl.obolibrary.org/obo/GO_0007292		
HP:0031518	biolink:PhenotypicFeature	Absent posterior alpha rhythm	Lack of normal alpha rhythm in the EEG. Alpha rhythm has been defined as a rhythm at 8-13 Hz occurring during wakefulness over the posterior regions of the head, generally with higher voltage over the occipital areas. Amplitude is variable but is mostly below 50 microvolt in adults. It is best seen with eyes closed and under conditions of physical relaxation and relative mental inactivity. It is blocked or attenuated by attention, especially visual and mental effort. One should here note the difference between the terms alpha rhythm and alpha activity: Alpha activity refers to activity in the range of 8-13 Hz and alpha rhythm is the activity of 8-13 Hz with specific characteristics as defined above.		hp.json		http://purl.obolibrary.org/obo/HP_0031518		
HP:0031511	biolink:PhenotypicFeature	Diagonal earlobe crease	Diagonal earlobe creases run from the lower pole of the external meatus, diagonally backwards to the edge of the lobe at approximately 45 degrees.		hp.json		http://purl.obolibrary.org/obo/HP_0031511		
HP:0031512	biolink:PhenotypicFeature	Abnormal cutaneous collagen fibril morphology			hp.json		http://purl.obolibrary.org/obo/HP_0031512		
HP:0031513	biolink:PhenotypicFeature	Luse bodies	Fusiform collagen fibers with abnormally long spacing (exceeding 100 nm) between electron-dense bands.		hp.json		http://purl.obolibrary.org/obo/HP_0031513		
CHEBI:142767	biolink:ChemicalSubstance	alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-Glc-yl group	A beta-D-glucosyl group derived from the trisaccharide N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucose.  Implied reactive epitope within ganglioside GM3.	PMID:7534889	hp.json	5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl|alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl|Neu5Acalpha2-3Galbeta1-4Glcbeta-yl|3'-sialyllactosyl|alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->4)-beta-D-Glcp-yl	http://purl.obolibrary.org/obo/CHEBI_142767		3_STAR
HP:0031514	biolink:PhenotypicFeature	Increased proportion of exhausted T cells	An abnormally elevated proportion of exhausted T cells (Tex) among circulating T cells. T cell exhaustion is a distinct differentiation state that can be distinguished from naive, effector, and memory T cells. Compared to effector (TE) and memory (TMEM) T cells, exhausted T cells (TEX) display impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity). TEX have limited proliferative potential, especially compared to some subsets of TMEM and naive T cells.		hp.json		http://purl.obolibrary.org/obo/HP_0031514		
HP:0031519	biolink:PhenotypicFeature	Cauliflower deformity of dermal collagen fibrils	An anomaly of collagen fibers of the skin that is said to resemble a cauliflower and can be appreciated by electron microscopy.		hp.json		http://purl.obolibrary.org/obo/HP_0031519		
NBO:0000032	biolink:NamedThing	paralysis	"Loss of power of voluntary movement in a muscle through injury or disease of its nerve supply." [JAX:<new dbxref>]		hp.json		http://purl.obolibrary.org/obo/NBO_0000032		
NBO:0000030	biolink:NamedThing	hyperactivity	"A kinesthetic behavior which relatively increased." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0000030		
HP:0031520	biolink:PhenotypicFeature	Groin pain	An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the groin region.		hp.json		http://purl.obolibrary.org/obo/HP_0031520		
HP:0031521	biolink:PhenotypicFeature	Vaginal clear cell adenocarcinoma	A type of adenocarcinoma originating in the vagina and characterized by large cells with moderate to abundant clear cytoplasm.		hp.json	Clear cell adenocarcinoma of the vagina	http://purl.obolibrary.org/obo/HP_0031521		
HP:0031526	biolink:PhenotypicFeature	Subretinal fluid	Edema/fluid accumulating between the retinal pigment epithelium and Bruch's membrane.		hp.json	Sub-retinal fluid	http://purl.obolibrary.org/obo/HP_0031526		
HP:0031527	biolink:PhenotypicFeature	Intraretinal fluid	Edema/fluid accumulating within the retinal layers.		hp.json	Intra-retinal fluid	http://purl.obolibrary.org/obo/HP_0031527		
HP:0031528	biolink:PhenotypicFeature	Subretinal deposits	Deposits accumulating between the outer retina and the retinal pigment epithelium.		hp.json		http://purl.obolibrary.org/obo/HP_0031528		
HP:0031529	biolink:PhenotypicFeature	Focal subretinal deposits	Deposits accumulating between the outer retina and the retinal pigment epithelium and that have a focal distribution.		hp.json		http://purl.obolibrary.org/obo/HP_0031529		
HP:0006599	biolink:PhenotypicFeature	Medial widening of clavicles		UMLS:C1866729	hp.json		http://purl.obolibrary.org/obo/HP_0006599		
HP:0031522	biolink:PhenotypicFeature	Cervical clear cell adenocarcinoma	A type of adenocarcinoma originating in the cervix and characterized by large cells with moderate to abundant clear cytoplasm.		hp.json	Clear cell carcinoma of cervix	http://purl.obolibrary.org/obo/HP_0031522		
HP:0031523	biolink:PhenotypicFeature	Salivary gland oncocytoma	A benign epithelial neoplasm composed of layers of oncocytes (small round nucleus, micro-granular, eosinophilic cytoplasm with numerous tightly-packed mitochondria)		hp.json	Parotid oncocytoma	http://purl.obolibrary.org/obo/HP_0031523		
HP:0031524	biolink:PhenotypicFeature	Ampulla of Vater carcinoma	A carcinoma originating in the ampulla of Vater (also known as the hepatopancreatic duct), which is formed by the union of the pancreatic duct and the common bile duct.		hp.json		http://purl.obolibrary.org/obo/HP_0031524		
HP:0031525	biolink:PhenotypicFeature	Keratoacanthoma	Keratoacanthoma (KA) is a common benign epithelial tumour that originates from the pilosebaceous glands. In most cases, it is characterized by rapid evolution, followed by spontaneous resolution over 4 to 6 months. KA usually presents as a solitary flesh-coloured nodule with a central keratin plug on the sun-exposed skin of elderly individuals.		hp.json		http://purl.obolibrary.org/obo/HP_0031525		
HP:0006595	biolink:PhenotypicFeature	Scapulohumeral synostosis	Bony fusion between the humerus and scapula, leading to an impairment in mobility of the affected shoulder joint.	UMLS:C1865362	hp.json	Synostosis of shoulder joint|Humero-scapulo synostosis|Fusion of shoulder blade to long bone in upper arm|Humeroscapular synostosis	http://purl.obolibrary.org/obo/HP_0006595		
NBO:0000003	biolink:NamedThing	emotional behavior	"Behavior related to the complex psychophysiological experience of an individual's state of mind as interacting with biochemical (internal) and environmental (external) influences." [wikipedia:Emotions]		hp.json	mood|affective behaviour	http://purl.obolibrary.org/obo/NBO_0000003		
HP:0006596	biolink:PhenotypicFeature	Restricted chest movement		UMLS:C4025015	hp.json	Restricted chest movement	http://purl.obolibrary.org/obo/HP_0006596		
NBO:0000001	biolink:NamedThing	body part movement	A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC]		hp.json	stationary movement	http://purl.obolibrary.org/obo/NBO_0000001		
HP:0006597	biolink:PhenotypicFeature	Diaphragmatic paralysis	The presence of a paralyzed diaphragm.	UMLS:C0035232|SNOMEDCT_US:64228003|MSH:D012133	hp.json	Paralysed diaphragm|Paralyzed diaphragm|Diaphragmatic paralysis	http://purl.obolibrary.org/obo/HP_0006597		
HP:0006598	biolink:PhenotypicFeature	Irregular ossification at anterior rib ends		UMLS:C1850083	hp.json		http://purl.obolibrary.org/obo/HP_0006598		
HP:0006591	biolink:PhenotypicFeature	Absent glenoid fossa	Lack of development of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus.	UMLS:C4021589	hp.json	Aplasia of the glenoid fossa	http://purl.obolibrary.org/obo/HP_0006591		
GO:0019230	biolink:BiologicalProcess	proprioception	The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors.	Wikipedia:Proprioception	hp.json		http://purl.obolibrary.org/obo/GO_0019230		
HP:0006593	biolink:PhenotypicFeature	Anomalous rib insertion to vertebrae		UMLS:C1861704	hp.json		http://purl.obolibrary.org/obo/HP_0006593		
NBO:0000009	biolink:NamedThing	locomotory behavior phenotype	"Observable characteristic of behavior associated with the specific movement from place to place of an organism." [NBO:GVG]		hp.json	pathological locomotory behaviour	http://purl.obolibrary.org/obo/NBO_0000009		
NBO:0000008	biolink:NamedThing	rhythmic behavior			hp.json		http://purl.obolibrary.org/obo/NBO_0000008		
NBO:0000007	biolink:NamedThing	mouth movement	The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC]		hp.json	mouth part movement|other moved mouth parts	http://purl.obolibrary.org/obo/NBO_0000007		
NBO:0000006	biolink:NamedThing	learning and/or memory behavior	"Behavior related to the acquisition and processing of information and/or the storage and retrieval of this information over time." [GO:jic]		hp.json	learning and/or memory behaviour	http://purl.obolibrary.org/obo/NBO_0000006		
HP:0031530	biolink:PhenotypicFeature	Multifocal subretinal deposits	Deposits accumulating between the outer retina and the retinal pigment epithelium and that are distributed with multiple foci.		hp.json		http://purl.obolibrary.org/obo/HP_0031530		
GO:0007268	biolink:BiologicalProcess	chemical synaptic transmission	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.	Wikipedia:Neurotransmission	hp.json	synaptic transmission|signal transmission across a synapse|neurotransmission	http://purl.obolibrary.org/obo/GO_0007268		goslim_synapse
GO:0007267	biolink:BiologicalProcess	cell-cell signaling	Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell.  Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.		hp.json	cell-cell signalling	http://purl.obolibrary.org/obo/GO_0007267		goslim_plant|goslim_chembl
HP:0031531	biolink:PhenotypicFeature	Sub-RPE deposits	Deposits accumulating between the retinal pigment epithelium and Bruch's membrane.		hp.json		http://purl.obolibrary.org/obo/HP_0031531		
HP:0031532	biolink:PhenotypicFeature	Focal sub-RPE deposits	Deposits accumulating between the retinal pigment epithelium and Bruch's membrane and that are distributed in a single focus.		hp.json		http://purl.obolibrary.org/obo/HP_0031532		
GO:0007272	biolink:BiologicalProcess	ensheathment of neurons	The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.		hp.json	ionic insulation of neurons by glial cells	http://purl.obolibrary.org/obo/GO_0007272		
HP:0031537	biolink:PhenotypicFeature	Anomalous origin of the left circumflex artery from the right coronary artery	An abnormal origin of the left circumflex artery (LCX) from the right coronary artery. Normally, the left anterior descending (LAD) and the LCX arise from a common stem, the left main coronary artery (LMCA).		hp.json		http://purl.obolibrary.org/obo/HP_0031537		
HP:0031538	biolink:PhenotypicFeature	Abnormal dermoepidermal junction morphology	Any anomaly of the structure of the acellular zone that is between the dermis and the epidermis and which functions to bind the epidermis to the dermis and to serve as a selective barrier allowing the control of molecular and cellular exchanges between the two compartments.		hp.json		http://purl.obolibrary.org/obo/HP_0031538		
HP:0031539	biolink:PhenotypicFeature	Linear IgA deposits along the epidermal basement membrane zone	Presence of IgA antibodies in the dermoepidermal junction that are distributed in a linear pattern. This feature can be appreciated by immunofluorescence microscopy.		hp.json		http://purl.obolibrary.org/obo/HP_0031539		
HP:0031533	biolink:PhenotypicFeature	Multifocal sub-RPE deposits	Deposits accumulating between the retinal pigment epithelium and Bruch's membrane and that are distributed in multiple foci.		hp.json		http://purl.obolibrary.org/obo/HP_0031533		
HP:0031534	biolink:PhenotypicFeature	Passive dorsiflexion of the 5th finger more than 90 degrees	An abnormally increased ability to bend (dorsiflex) one's fifth finger. To assess this feature, the examiner requests to proband to extend the elbows,to bend the wrist back so that it forms a ninety degree angle to the forearm, and to extend the fingers. Then, the proband is requested to bend the fifth finger back as far as is possible without discomfort. If the angle of the fifth finger exceeds 90 degrees, this is considered to be abnormal.		hp.json		http://purl.obolibrary.org/obo/HP_0031534		
GO:0019249	biolink:BiologicalProcess	lactate biosynthetic process	The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid.		hp.json	lactate anabolism|lactate biosynthesis|lactate synthesis|lactate formation	http://purl.obolibrary.org/obo/GO_0019249		
HP:0031535	biolink:PhenotypicFeature	Increased theta frequency activity in EEG	Increased frequency of theta wave activity in the electroencephalogram. Theta waves have a frequency of 3.5-7.5 Hertz, and are present in very small amounts in healthy waking adult EEGs. Theta activity is normal in small very amounts in the healthy waking adult EEG in a symmetrical distribution.		hp.json		http://purl.obolibrary.org/obo/HP_0031535		
HP:0031536	biolink:PhenotypicFeature	Separate origin of the left anterior descending and left circumflex artery	Anomalous coronary origin whereby the left anterior descending (LAD) and the left circumflex artery (LCX) arise separately. Normally, these arteries arise from a common stem, the left main coronary artery (LMCA).		hp.json		http://purl.obolibrary.org/obo/HP_0031536		
NBO:0000011	biolink:NamedThing	social behavior	"A behavior that occurs predominantly or only, in individuals that are part of a group." [Wikipedia:Social_behavior]		hp.json	social behaviour	http://purl.obolibrary.org/obo/NBO_0000011		
GO:0140103	biolink:MolecularActivity	catalytic activity, acting on a glycoprotein	Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein.		hp.json		http://purl.obolibrary.org/obo/GO_0140103		
UBERON:0002085	biolink:AnatomicalEntity	interatrial septum	A cardiac septum that divides the left and right atria of the heart.	EMAPA:17011|NCIT:C32818|OpenCyc:Mx4rwGvku5wpEbGdrcN5Y29ycA|MA:0000084|EHDAA2:0000838|FMA:7108|SCTID:362016003|galen:InteratrialSeptum|VHOG:0000385|Wikipedia:Interatrial_septum|UMLS:C0225836|EHDAA:1896|OpenCyc:Mx4rpd49nLYEEduAAAACs2IKfQ	hp.json	atrium septum|interatrial septal wall|atrial septum	http://purl.obolibrary.org/obo/UBERON_0002085		pheno_slim|uberon_slim
UBERON:0002084	biolink:AnatomicalEntity	heart left ventricle	A cardiac ventricle that is in the left side of the heart.	galen:LeftVentricle|NCIT:C12871|CALOHA:TS-0439|EHDAA2:0002178|OpenCyc:Mx4rtW8v46gEEdudWQACs5b6Bw|MA:0000092|OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvVjj1pwpEbGdrcN5Y29ycA|EMAPA:17337|BTO:0001629|UMLS:C0225897|VHOG:0000718|SCTID:244385005|Wikipedia:Left_ventricle|FMA:7101	hp.json	ventriculus sinister cordis|left ventricle of heart|ventriculus sinister cordis|left cardiac ventricle|left ventricle|cardiac left ventricle	http://purl.obolibrary.org/obo/UBERON_0002084		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0002087	biolink:AnatomicalEntity	atrioventricular canal	The part of the heart connecting the atrium to the cardiac ventricle[ZFA]. In the developing heart, the constriction between the atrium and ventricle constitutes the atrial canal, and indicates the site of the future atrioventricular valves[WP].	XAO:0004123|FMA:71121|EMAPA:16546|ZFA:0001315|VHOG:0001473|TAO:0001315|EHDAA:764	hp.json	AVC|ependymal canal|atrial canal|canalis atrioventricularis|AV canal|atrio-ventricular canal	http://purl.obolibrary.org/obo/UBERON_0002087		pheno_slim|uberon_slim|vertebrate_core
UBERON:0002081	biolink:AnatomicalEntity	cardiac atrium	Cardiac chamber in which blood enters the heart.	ZFA:0000471|FMA:7099|EHDAA:1265|UMLS:C0018792|MESH:D006325|EHDAA2:0000154|MAT:0000496|MA:0000073|TAO:0000471|CALOHA:TS-0437|EFO:0000277|NCIT:C12728|galen:Atrium|EMAPA:16688|GAID:555|VHOG:0000175|BTO:0000903|EV:0100019|Wikipedia:Heart_atrium|SCTID:261405004|AAO:0010246	hp.json	cardiac atria|atrial tissue|atria|heart atrium|atrium|atrium of heart	http://purl.obolibrary.org/obo/UBERON_0002081		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0002080	biolink:AnatomicalEntity	heart right ventricle	A cardiac ventricle that is in the right side of the heart.	FMA:7098|OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvVjj1pwpEbGdrcN5Y29ycA|NCIT:C12870|BTO:0001630|EHDAA2:0000196|MA:0000093|galen:RightVentricle|SCTID:244384009|CALOHA:TS-0443|VHOG:0000717|UMLS:C0225883|Wikipedia:Right_ventricle|OpenCyc:Mx4rRMlc0KgNEdudWQACs5b6Bw|EMAPA:17340	hp.json	ventriculus dexter|cardiac right ventricle|right ventricle|ventriculus dexter|right ventricle of heart|right cardiac ventricle	http://purl.obolibrary.org/obo/UBERON_0002080		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0002082	biolink:AnatomicalEntity	cardiac ventricle	Cardiac chamber through which blood leaves the heart.	Wikipedia:Ventricle_(heart)|MAT:0000497|BTO:0000862|VHOG:0000435|UMLS:C0018827|XAO:0003193|EV:0100020|ZFA:0000009|EHDAA2:0004164|GAID:568|MA:0000091|CALOHA:TS-0444|EHDAA:1912|SCTID:277699000|OpenCyc:Mx4rvVjj1pwpEbGdrcN5Y29ycA|galen:Ventricle|TAO:0000009|MESH:D006352|AAO:0010249|EFO:0000317|EMAPA:17331|NCIT:C12730|FMA:7100	hp.json	heart ventricle|ventricle|lower chamber of heart|ventricle of heart	http://purl.obolibrary.org/obo/UBERON_0002082		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0002089	biolink:AnatomicalEntity	thoracodorsal vein	Companion vein of the thoracodorsal artery, draining the apical part of the latissimus dorsi and merging with the circumflex scapular vein to form a subscapular vein.	FMA:71213|EMAPA:37198|MA:0002238	hp.json		http://purl.obolibrary.org/obo/UBERON_0002089		human_reference_atlas
NCBITaxon:32443	biolink:OrganismalEntity	Teleostei		GC_ID:1	hp.json	teleost fishes	http://purl.obolibrary.org/obo/NCBITaxon_32443		
HP:0006508	biolink:PhenotypicFeature	Abnormality of tibial epiphyses		UMLS:C4025030	hp.json	Abnormality of end part of shinbone	http://purl.obolibrary.org/obo/HP_0006508		
HP:0006509	biolink:PhenotypicFeature	Diverticulosis of trachea	Tracheal diverticula are blind-ended outpouchings arising from the trachea. They are usually an incidental finding. Occasionally they can mimic pneumomediastinum. Tracheal diverticula are either congenital or acquired, in the latter case the most common causes are prolonged increased intraluminal pressure, e.g. chronic cough, COPD, tracheomalacia, and iatrogenic (e.g. post-surgical).	SNOMEDCT_US:14011008|UMLS:C0340213	hp.json	Tracheal diverticulum|Paratracheal air cyst|Tracheocele|Tracheal diverticulosis	http://purl.obolibrary.org/obo/HP_0006509		
HP:0006504	biolink:PhenotypicFeature	obsolete Anomaly of the limb diaphyses morphology			hp.json	Abnormality of shaft of long bone of the limbs	http://purl.obolibrary.org/obo/HP_0006504		
UBERON:0002074	biolink:AnatomicalEntity	hair shaft	The main part of the hair which is composed of trichocytes and is divided into the cortex and medulla.	NCIT:C33543|FMA:70728|BTO:0004672|EMAPA:36498|MA:0000159|UMLS:C0221961	hp.json	scapus pili|shaft of hair	http://purl.obolibrary.org/obo/UBERON_0002074		pheno_slim
HP:0006505	biolink:PhenotypicFeature	Abnormal limb epiphysis morphology	An anomaly of one or more epiphyses of a limb.	UMLS:C4021593	hp.json	Abnormality involving the epiphyses of the limbs|Abnormality of limb epiphysis morphology|Abnormal shape of end part of limb bones	http://purl.obolibrary.org/obo/HP_0006505		
UBERON:0002073	biolink:AnatomicalEntity	hair follicle	A tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open[GO].	MA:0000154|EMAPA:18771|EV:0100156|FMA:70660|BTO:0000554|GAID:934|UMLS:C0221971|EFO:0002464|VHOG:0001268|OpenCyc:Mx4rvVjOI5wpEbGdrcN5Y29ycA|CALOHA:TS-0432|NCIT:C13317|EMAPA:29741|MESH:D018859	hp.json	folliculus pili	http://purl.obolibrary.org/obo/UBERON_0002073		organ_slim|pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0002076	biolink:AnatomicalEntity	cuticle of hair	Smooth and glossy outer protective cell layer of hair shaft.	MA:0000157|EMAPA:35388|FMA:70933	hp.json	hair cuticle	http://purl.obolibrary.org/obo/UBERON_0002076		pheno_slim
UBERON:0002075	biolink:AnatomicalEntity	viscus	An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen.	XAO:0003034|AAO:0010386|UMLS:C0042779|FMA:7085|MESH:D014781|Wikipedia:Viscus|NCIT:C28287|MA:0000019|SCTID:118760003|RETIRED_EHDAA2:0002201|EMAPA:16245|BTO:0001491|EHDAA:512	hp.json	splanchnic tissue|viscera|visceral tissue|visceral organ system|visceral organ	http://purl.obolibrary.org/obo/UBERON_0002075		upper_level|organ_slim|pheno_slim|uberon_slim
HP:0006507	biolink:PhenotypicFeature	Aplasia/hypoplasia of the humerus	Absence (due to failure to form) or underdevelopment of the humerus.	UMLS:C4025031	hp.json	Absent/underdeveloped long bone in upper arm|Absent/small long bone in upper arm	http://purl.obolibrary.org/obo/HP_0006507		
HP:0006500	biolink:PhenotypicFeature	Abnormality of lower limb epiphysis morphology	An anomaly of one or more epiphyses of one or both legs.	UMLS:C4021595	hp.json	Abnormal shape of end part of lower limb end bone|Abnormality involving the epiphyses of the lower limbs	http://purl.obolibrary.org/obo/HP_0006500		
HP:0006501	biolink:PhenotypicFeature	Aplasia/Hypoplasia of the radius	A small/hypoplastic or absent/aplastic radius.	UMLS:C2749463	hp.json	Absence or underdevelopment of the radius bone of the arm|Absent/underdeveloped radius|Radial aplasia/hypoplasia|Absent/small radius	http://purl.obolibrary.org/obo/HP_0006501		
UBERON:0002072	biolink:AnatomicalEntity	hypodermis	Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP].	TAO:0001136|Wikipedia:Hypodermis|BTO:0001314|CALOHA:TS-2366|ZFA:0001136|NCIT:C33645|UMLS:C0278403|EMAPA:37505|FMA:70544	hp.json	hypoderm|tela subcutanea|vertebrate hypodermis|superficial fascia|subcutis|sub-tegumental tissue|tela subcutanea|subtegumental tissue|subcutaneous tissue|subcutaneous tissue	http://purl.obolibrary.org/obo/UBERON_0002072		pheno_slim|human_reference_atlas|uberon_slim|vertebrate_core
HP:0006502	biolink:PhenotypicFeature	Aplasia/Hypoplasia involving the carpal bones	Absence or underdevelopment of the carpal bones.	UMLS:C4025033	hp.json	Absent/small wrist bones|Absent/underdeveloped wrist bones	http://purl.obolibrary.org/obo/HP_0006502		
HP:0006503	biolink:PhenotypicFeature	Aplasia/hypoplasia involving forearm bones	Absence (due to failure to form) or underdevelopment of one or more forearm bones.	UMLS:C4025032	hp.json	Absent/small forearm bones|Absent/underdeveloped forearm bones	http://purl.obolibrary.org/obo/HP_0006503		
UBERON:0002078	biolink:AnatomicalEntity	right cardiac atrium	A cardiac atrium that is in the left side of the heart. It receives deoxygenated blood. In mammals, this comes from the superior and inferior vena cava and the coronary sinus, and pumps it into the right ventricle through the tricuspid valve.	OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rDJ89oqgPEdudWQACs5b6Bw|BTO:0001703|EMAPA:17321|SCTID:244383003|AAO:0010248|VHOG:0000328|MA:0000075|Wikipedia:Right_atrium|FMA:7096|XAO:0003192|UMLS:C0225844|OpenCyc:Mx4runNcs6fqEdudWQACs5b6Bw|EHDAA2:0000290|NCIT:C12868|galen:RightAtrium	hp.json	atrium dextrum|right atrium|cardiac right atrium|right cardiac atrium|heart right atrium|atrium dextrum|right atrium of heart	http://purl.obolibrary.org/obo/UBERON_0002078		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0002077	biolink:AnatomicalEntity	cortex of hair	A cortex that is part of a hair [Automatically generated definition].	MA:0000156|FMA:70934|EMAPA:35387	hp.json	hair cortex|coat hair cortex|cortex of coat hair|cortex of coat/hair|coat/hair cortex	http://purl.obolibrary.org/obo/UBERON_0002077		pheno_slim
UBERON:0002079	biolink:AnatomicalEntity	left cardiac atrium	A cardiac atrium that is in the left side of the heart. It receives oxygenated blood from the pulmonary veins, In mammals this is pumped into the left ventricle, via the Mitral valve.	AAO:0010247|BTO:0001702|OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rDJ89oqgPEdudWQACs5b6Bw|galen:LeftAtrium|Wikipedia:Left_atrium|MA:0000074|EHDAA2:0000275|SCTID:244387002|FMA:7097|VHOG:0000369|OpenCyc:Mx4rkJN1AagEEdudWQACs5b6Bw|XAO:0003191|NCIT:C12869|EMAPA:17315|UMLS:C0225860	hp.json	left cardiac atrium|atrium sinistrum|atrium sinistrum|heart left atrium|left atrium|cardiac left atrium|left atrium of heart	http://purl.obolibrary.org/obo/UBERON_0002079		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0002063	biolink:AnatomicalEntity	sinus venosus	The sinus venosus is a large cardiac chamber at the inflow tract that receives venous blood from systemic circulation. precedes the atrium on the venous side of the chordate heart.	FMA:70303|ZFA:0000154|NCIT:C34300|TAO:0000154|NCIT:C34299|Wikipedia:Sinus_venosus|EHDAA2:0001839|EHDAA:480|UMLS:C0225857|EMAPA:16237|VHOG:0000177|UMLS:C0231084|AAO:0010505	hp.json	sinus venosus cordis|venosus|venarum sinus|sinus venarum|venosus|sinus venosus cordis|sinus venarum|venarum sinus|venarum|inflow tract|venarum	http://purl.obolibrary.org/obo/UBERON_0002063		vertebrate_core|pheno_slim|uberon_slim
UBERON:0002062	biolink:AnatomicalEntity	endocardial cushion	The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves[GO]. Swellings of tissue present between the endocardial and myocardial cell layers that will give rise to the interstitial cells of the cardiac valves[ZFA].	FMA:70302|EHDAA2:0000434|MA:0000078|EHDAA:2586|XAO:0004189|MESH:D054089|EHDAA2:0004028|VHOG:0000932|Wikipedia:Atrioventricular_cushions|ZFA:0001317|TAO:0001317|EMAPA:16696	hp.json	atrioventricular cushion|cardiac cushion|endocardial cushion tissue|atrioventricular canal cushion|AV cushion|atrioventricular cushion|endocardial cushions|cardiac cushion	http://purl.obolibrary.org/obo/UBERON_0002062		pheno_slim|uberon_slim|vertebrate_core
UBERON:0002065	biolink:AnatomicalEntity	posterior cardinal vein	One of two paired cardinal veins that return blood from the body of the embryo[Kardong].	FMA:70314|TAO:0000477|AAO:0010511|XAO:0000241|NCIT:C34257|UMLS:C0231087|EHDAA2:0001486|VHOG:0000111|EHDAA:1316|BTO:0004386|EMAPA:16357|ZFA:0000477	hp.json	inferior cardinal vein|PCV|postcardinal vein|caudal cardinal veins|axial vein	http://purl.obolibrary.org/obo/UBERON_0002065		vertebrate_core|pheno_slim|uberon_slim
UBERON:0002061	biolink:AnatomicalEntity	truncus arteriosus	The truncus arteriosus and bulbus cordis are divided by the aorticopulmonary septum. The truncus arteriosus gives rise to the ascending aorta and the pulmonary trunk. The bulbus cordis gives rise to the smooth parts (outflow tract) of the left and right ventricles.	MESH:D014338|SCTID:308828009|FMA:70301|UMLS:C1519589|Wikipedia:Truncus_arteriosus_(embryology)|EMAPA:35887|OpenCyc:Mx4rquH9YKgNEdudWQACs5b6Bw|EHDAA2:0004143|NCIT:C34317|GAID:554|MA:0000103	hp.json		http://purl.obolibrary.org/obo/UBERON_0002061		uberon_slim
UBERON:0002060	biolink:AnatomicalEntity	femoral artery	The femoral artery is a large artery in the muscles of the thigh. It is a continuation of external iliac artery where it enters the femoral triangle at the mid inguinal point behind the inguinal ligament. It leaves femoral triangle through apex beneath the sartorius muscle. It enters the popliteal fossa by passing through the 5th osseo-aponeurotic(adductor hiatus) opening of adductor magnus where it becomes the Popliteal Artery. [WP,unvetted].	BTO:0001624|GAID:494|AAO:0010222|galen:FemoralArtery|OpenCyc:Mx4rwHMI05wpEbGdrcN5Y29ycA|NCIT:C12715|MESH:D005263|CALOHA:TS-0321|EMAPA:35342|MA:0001951|UMLS:C0015801|FMA:70248	hp.json	arteria femoralis	http://purl.obolibrary.org/obo/UBERON_0002060		uberon_slim
UBERON:0002067	biolink:AnatomicalEntity	dermis	The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP].	NCIT:C12701|AAO:0000128|CALOHA:TS-2076|EFO:0000953|FMA:70323|Wikipedia:Dermis|VHOG:0000108|MA:0000152|EV:0100154|GAID:1321|UMLS:C0011646|MAT:0000153|XAO:0000217|EMAPA:17527|ZFA:0001119|MESH:D020405|SCTID:361696001|MIAA:0000153|TAO:0001119|BTO:0000294	hp.json	corium|cutis|vertebrate dermis|corium|corium	http://purl.obolibrary.org/obo/UBERON_0002067		vertebrate_core|pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0002069	biolink:AnatomicalEntity	stratum granulosum of epidermis	The layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis.	UMLS:C0221923|FMA:70344|MA:0000805|EMAPA:32786|NCIT:C33627|BTO:0000361	hp.json	granular layer of epidermis|stratum granulosum|epidermis stratum granulosum|epidermis granular layer	http://purl.obolibrary.org/obo/UBERON_0002069		pheno_slim|human_reference_atlas
UBERON:0002068	biolink:AnatomicalEntity	urachus	A fibrous remnant of the allantoic stalk, a narrow fetal canal connecting the apex of the urinary bladder with the umbilicus located in the space of Retzius, between the transversalis fascia anteriorly and the peritoneum posteriorly. its lumen is normally obliterated during development, transforming the urachus into a solid cord, a functionless remnant that persists throughout life as the median umbilical ligament; failure of complete lumen obliteration may result in distinct congenital urachal remnant anomalies[MP].	NCIT:C12338|EMAPA:18323|EHDAA2:0002137|VHOG:0000735|FMA:70343|GAID:1313|EHDAA:7016|UMLS:C0041916|MESH:D014497|EHDAA:9332|RETIRED_EHDAA2:0002138|MA:0001701	hp.json		http://purl.obolibrary.org/obo/UBERON_0002068		pheno_slim|uberon_slim
OBO:uberon/core#extends_fibers_into	biolink:NamedThing	extends_fibers_into			hp.json		http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into		
UBERON:0002052	biolink:AnatomicalEntity	adrenal gland capsule	The thick capsule of dense irregular connective tissue that surrounds each adrenal gland and contains scattered elastic fibers; the capsule contains a rich plexus of blood vessels (mainly small arteries) and numerous nerve fibers; some blood vessels and nerves enter the substance of the gland in the trabeculae that extend inward from the capsule and then leave the trabeculae to enter the cortex.	FMA:69087|UMLS:C1181304|NCIT:C32050|MA:0000117	hp.json	adrenal capsule|capsule of adrenal gland	http://purl.obolibrary.org/obo/UBERON_0002052		pheno_slim
UBERON:0002051	biolink:AnatomicalEntity	epithelium of bronchiole	An epithelium that is part of a bronchiole [Automatically generated definition].	UMLS:C1181296|FMA:69077|CALOHA:TS-0570|MA:0001772|BTO:0001866|NCIT:C48942|FMA:62497|EMAPA:32693	hp.json	epithelial tissue of lobular bronchiole|epithelium of lobular bronchiole|bronchiole epithelial tissue|bronchiolar epithelium|lobular bronchiole epithelium|lobular bronchiole epithelial tissue|epithelial tissue of bronchiole|bronchiole epithelium	http://purl.obolibrary.org/obo/UBERON_0002051		pheno_slim
UBERON:0002050	biolink:AnatomicalEntity	embryonic structure	Anatomical structure that is part of an embryo.	NCIT:C13229|FMA:69067|RETIRED_EHDAA2:0003169|SCTID:667009|TAO:0001105|CALOHA:TS-2110|AAO:0000138|UMLS:C0013948|XAO:0003042|GAID:407|VSAO:0000178|BILA:0000034|EFO:0000461|FBbt:00004208|BTO:0000174|ZFA:0001105|MESH:D004628	hp.json	embryonale Struktur|developing structure|developing embryonic structure|embryonic structures|embryonic anatomical structure	http://purl.obolibrary.org/obo/UBERON_0002050		vertebrate_core|efo_slim|inconsistent_with_fma
GO:0140112	biolink:BiologicalProcess	extracellular vesicle biogenesis	The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.		hp.json	extracellular vesicle assembly	http://purl.obolibrary.org/obo/GO_0140112		
UBERON:0002059	biolink:AnatomicalEntity	submandibular ganglion	The ganglion associated with the lingual nerve that provides postsynaptic fibers to the submandibular and sublingual glands.	NCIT:C52558|EMAPA:36276|EHDAA2:0001942|BTO:0001318|EHDAA:6710|UMLS:C0229063|MA:0002470|FMA:6966	hp.json	mandibular ganglion|ganglion submandibulare|ganglion submandibulare|lingual ganglion|Blandin`s ganglion|maxillary ganglion|submaxillary ganglion	http://purl.obolibrary.org/obo/UBERON_0002059		uberon_slim|pheno_slim
UBERON:0002056	biolink:AnatomicalEntity	inferior suprarenal artery	Each renal artery gives off some small inferior suprarenal branches to the suprarenal gland, the ureter, and the surrounding cellular tissue and muscles. [WP,unvetted].	FMA:69264|MA:0002056|NCIT:C52737|UMLS:C0226334|EMAPA:37088	hp.json	arteria suprarenalis inferior	http://purl.obolibrary.org/obo/UBERON_0002056		uberon_slim|human_reference_atlas
UBERON:0002058	biolink:AnatomicalEntity	main ciliary ganglion	A parasympathetic ganglion located in the posterior orbit that contains preganglionic nerves and postganglionic neurons of the oculomotor nerve, connects to the Edinger-Westphal nucleus via the oculomotor nerve and the eye muscles via the short ciliary nerve.	FMA:6964|VHOG:0000805|MA:0001136|EFO:0002559|EHDAA:5623|EMAPA:18222|BAMS:GcIII|NLXANAT:100304|EHDAA2:0000251	hp.json	ciliary ganglion|ganglion ciliare	http://purl.obolibrary.org/obo/UBERON_0002058		uberon_slim|pheno_slim|efo_slim
UBERON:0002057	biolink:AnatomicalEntity	phrenic artery	An artery that supplies the diaphragm.	MA:0002019|FMA:69330|EMAPA:37108|NCIT:C33320|UMLS:C1181536	hp.json		http://purl.obolibrary.org/obo/UBERON_0002057		uberon_slim
HP:0006538	biolink:PhenotypicFeature	Recurrent bronchopulmonary infections	An increased susceptibility to bronchopulmonary infections as manifested by a history of recurrent bronchopulmonary infections.	UMLS:C2169795	hp.json	Recurrent infections in bronchi and lungs	http://purl.obolibrary.org/obo/HP_0006538		
HP:0006539	biolink:PhenotypicFeature	Bronchial cartilage hypoplasia		UMLS:C4025024	hp.json	Underdevelopment of the bronical cartilage	http://purl.obolibrary.org/obo/HP_0006539		
HP:0006533	biolink:PhenotypicFeature	Bronchodysplasia		UMLS:C4025025	hp.json		http://purl.obolibrary.org/obo/HP_0006533		
HP:0006535	biolink:PhenotypicFeature	Recurrent intrapulmonary hemorrhage	A recurrent hemorrhage occurring within the lung.	UMLS:C3805919	hp.json	Recurrent intrapulmonary haemorrhage|Recurrent pulmonary haemorrhage|Recurrent bleeding into lungs|Recurrent pulmonary hemorrhage	http://purl.obolibrary.org/obo/HP_0006535		
HP:0006536	biolink:PhenotypicFeature	Airway obstruction	Obstruction of conducting airways of the lung.	MSH:D008173|UMLS:C0600260	hp.json	Obstructive lung disease|Pulmonary obstruction	http://purl.obolibrary.org/obo/HP_0006536		
HP:0006530	biolink:PhenotypicFeature	Abnormal pulmonary interstitial morphology	Abnormality of the lung parenchyma extending to the pulmonary interstitium and leading to diffuse pulmonary fibrosis.	UMLS:C0206062|SNOMEDCT_US:233703007|MSH:D017563	hp.json	Interstitial lung disease|Interstitial pulmonary disease|Abnormal lung parenchyma morphology|Abnormality in area between air sacs in lung	http://purl.obolibrary.org/obo/HP_0006530		
HP:0006531	biolink:PhenotypicFeature	Pleural lymphangiectasia		UMLS:C1856139	hp.json		http://purl.obolibrary.org/obo/HP_0006531		
HP:0006532	biolink:PhenotypicFeature	Recurrent pneumonia	An increased susceptibility to pneumonia as manifested by a history of recurrent episodes of pneumonia.	SNOMEDCT_US:128601007|SNOMEDCT_US:699014000|UMLS:C0748140|UMLS:C0694550|UMLS:C0876973|UMLS:C1859117	hp.json	Recurrent pneumonia|Pulmonary infections|Multiple pulmonary infections|Pneumonia, recurrent|Pneumonia, recurrent episodes|Recurrent pulmonary infections|Pulmonary infection|pulmonary infections, recurrent	http://purl.obolibrary.org/obo/HP_0006532		
OBO:uberon/core#sexually_homologous_to	biolink:NamedThing	sexually_homologous_to			hp.json		http://purl.obolibrary.org/obo/uberon/core#sexually_homologous_to		
HP:0006548	biolink:PhenotypicFeature	Pulmonary arteriovenous malformation	Pulmonary arteriovenous malformation, a condition most commonly associated with hereditary hemorrhagic telangiectasia, is an abnormal communication between the pulmonary artery and pulmonary vein without an intervening capillary communication. HRCT images usually show a coarse spidery appearance of the peripheral vascular markings in the lungs. More specific findings are obtained in the pulmonary angiogram where the normally invisible capillary phase is replaced by irregular vascular channels bridging the peripheral branches of pulmonary arteries and veins.	Fyler:2210|UMLS:C1857690	hp.json	Pulmonary AV malformation	http://purl.obolibrary.org/obo/HP_0006548		
HP:0006549	biolink:PhenotypicFeature	Unilateral primary pulmonary dysgenesis		UMLS:C4021592	hp.json	Primary pulmonary dysgenesis, unilateral	http://purl.obolibrary.org/obo/HP_0006549		
HP:0006544	biolink:PhenotypicFeature	Extrapulmonary sequestrum	A type of pulmonary sequestration that is completely enclosed in its own pleural sac, occurring above, within, or below the diaphragm, and without communication with the tracheobronchial tree.	UMLS:C4025023|UMLS:C4020814	hp.json	Diaphragmatic sequestrum	http://purl.obolibrary.org/obo/HP_0006544		
HP:0006541	biolink:PhenotypicFeature	obsolete Chronic obstructive airway disease from birth			hp.json		http://purl.obolibrary.org/obo/HP_0006541		
HP:0006543	biolink:PhenotypicFeature	Cardiorespiratory arrest		UMLS:C0600228|MSH:D006323|SNOMEDCT_US:410430005	hp.json		http://purl.obolibrary.org/obo/HP_0006543		
HP:0006519	biolink:PhenotypicFeature	Alveolar cell carcinoma	Adenocarcinoma of the Bronchus.	SNOMEDCT_US:112677002|MSH:D002282|SNOMEDCT_US:373627005|UMLS:C0007120|SNOMEDCT_US:36310008	hp.json		http://purl.obolibrary.org/obo/HP_0006519		
HP:0006515	biolink:PhenotypicFeature	Interstitial pneumonitis		SNOMEDCT_US:64667001|UMLS:C0206061|MSH:D017563	hp.json		http://purl.obolibrary.org/obo/HP_0006515		
HP:0006516	biolink:PhenotypicFeature	Hypersensitivity pneumonitis	Hypersensitivity pneumonitis involves inhalation of an antigen. This leads to an exaggerated immune response and a following inflammation of the alveoli within the lungs. The main feature of chronic hypersensitivity pneumonitis on lung biopsies is expansion of the interstitium by lymphocytes accompanied by an occasional multinucleated giant cell or loose granuloma. After exposure to the provoking antigen, following symptoms can be seen: fever, chills, malaise, cough, hemoptysis, chest tightness, dyspnea, rash, swelling and headache and can be completely reversible, based on the duration of the illness, categorized as acute (HP:0011009), subacute (HP:0011011), and chronic (HP:0011010).	SNOMEDCT_US:37471005|UMLS:C0002390|MSH:D000542	hp.json		http://purl.obolibrary.org/obo/HP_0006516		
HP:0006517	biolink:PhenotypicFeature	Intraalveolar phospholipid accumulation	Accumulation of amorphous PAS-positive material in the space betweem alveolar macrophages, sometimes as condensed form (oval bodies) are typically found in alveolar proteinosis.	MSH:D011649|SNOMEDCT_US:10501004|UMLS:C0034050	hp.json	Alveolar proteinosis|Pulmonary alveolar proteinosis|Detection of PAS-positive extracellular material in broncho-alveolar lavage	http://purl.obolibrary.org/obo/HP_0006517		
HP:0006518	biolink:PhenotypicFeature	Pulmonary venous occlusion	Substantial narrowing or blockage of small pulmonary veins as a result of disorganized smooth muscle hypertrophy and collagen matrix deposition.	SNOMEDCT_US:89420002|MSH:D011668|Fyler:3002|UMLS:C0034091|UMLS:C4280802	hp.json	Pulmonary venoocclusive disease|Pulmonary venous stenosis	http://purl.obolibrary.org/obo/HP_0006518		
HP:0006511	biolink:PhenotypicFeature	Laryngeal stridor	An abnormal high-pitched noisy sound, occurring during inhalation or exhalation caused by the incomplete obstruction in the throat.	SNOMEDCT_US:406444002|MSH:D007826|SNOMEDCT_US:53787002|SNOMEDCT_US:41432000|UMLS:C0023066	hp.json	Laryngeal stidor	http://purl.obolibrary.org/obo/HP_0006511		
HP:0006514	biolink:PhenotypicFeature	Intraalveolar nodular calcifications		UMLS:C4025028	hp.json		http://purl.obolibrary.org/obo/HP_0006514		
HP:0006510	biolink:PhenotypicFeature	Chronic pulmonary obstruction	An anomaly that is characterized progressive airflow obstruction that is only partly reversible, inflammation in the airways, and systemic effects or comorbities.	UMLS:C0024117|MSH:D029424|SNOMEDCT_US:13645005	hp.json	Chronic obstructive pulmonary disease|COPD	http://purl.obolibrary.org/obo/HP_0006510		
UBERON:0002090	biolink:AnatomicalEntity	postcranial axial skeleton	The postcranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA].	AAO:0000034|XAO:0003073|ZFA:0000317|EHDAA2:0000161|TAO:0000317|EMAPA:17214|MA:0002986|VSAO:0000093|MAT:0000148|EFO:0000942|EHDAA:5049|VHOG:0000317|EMAPA:37721|FMA:71221|MIAA:0000148	hp.json	axial skeleton|post-cranial axial skeleton|axial skeleton	http://purl.obolibrary.org/obo/UBERON_0002090		efo_slim|uberon_slim|vertebrate_core|pheno_slim
UBERON:0002095	biolink:AnatomicalEntity	mesentery	Anatomical organ component composed of a double layer of serous membrane that suspends a viscus from the body wall or connects adjacent viscera and in doing so conveys blood vessels, lymphatics and nerves to and from the viscera. Examples: greater omentum, broad ligament of uterus, sigmoid mesocolon.	MESH:D008643|GAID:21|EV:0100083|AAO:0011061|UMLS:C0025474|BTO:0001380|galen:Mesentery|NCIT:C33103|FMA:7144	hp.json	mesentery (generic)|generic mesentery	http://purl.obolibrary.org/obo/UBERON_0002095		pheno_slim|uberon_slim|vertebrate_core
HP:0006527	biolink:PhenotypicFeature	Lymphocytic interstitial pneumonia	Lymphocytic interstitial pneumonitis is a benign lymphoproliferative disorder of the lung that is characterized by the presence of a dense, predominantly lymphocytic interstitial infiltrate (lymphocytes, plasma cells, other elements of the lymphoreticular system) that expands the alveolar septa.	MSH:C562489|SNOMEDCT_US:44274007|UMLS:C0264511	hp.json	Lymphoid interstitial pneumonia|Lymphocytic interstitial pneumonitis|Lymphoid interstitial pneumonitis	http://purl.obolibrary.org/obo/HP_0006527		
HP:0006528	biolink:PhenotypicFeature	Chronic lung disease	According to the definitions of the American and British Thoracic Societies, including pulmonary functional tests, X-rays, and CT scans for items such as fibrosis, bronchiectasis, bullae, emphysema, nodular or lymphomatous abnormalities.	SNOMEDCT_US:413839001|UMLS:C0746102	hp.json	Chronic lung disease	http://purl.obolibrary.org/obo/HP_0006528		
UBERON:0002097	biolink:AnatomicalEntity	skin of body	The organ covering the body that consists of the dermis and epidermis.	EFO:0000962|CALOHA:TS-0934|OpenCyc:Mx4rvVjX3ZwpEbGdrcN5Y29ycA|UMLS:C1123023|FMA:7163|NCIT:C12470|BTO:0001253|EMAPA:17525|MFMO:0000099|Wikipedia:Skin|MESH:D012867|EHDAA2:0001844|XAO:0000023|galen:Skin|SCTID:181469002	hp.json	integumental organ|pelt|skin|skin organ|integument|entire skin|entire integument	http://purl.obolibrary.org/obo/UBERON_0002097		pheno_slim|efo_slim|human_reference_atlas|uberon_slim|major_organ
HP:0006529	biolink:PhenotypicFeature	Abnormal pulmonary lymphatics	An abnormality of the pulmonary lymphatic chain.	UMLS:C4025026	hp.json		http://purl.obolibrary.org/obo/HP_0006529		
UBERON:0002092	biolink:AnatomicalEntity	brain dura mater	The fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer.	MA:0000815|UMLS:C0459393|NCIT:C49332|SCTID:309321003|VHOG:0000270|FMA:71236|EV:0100313|EMAPA:32668	hp.json	dura mater encephali|dura mater of brain|dura mater cranialis|cranial dura mater	http://purl.obolibrary.org/obo/UBERON_0002092		pheno_slim
HP:0006522	biolink:PhenotypicFeature	Repeated pneumothoraces		UMLS:C4025027	hp.json	Repeated pneumothorax	http://purl.obolibrary.org/obo/HP_0006522		
UBERON:0002091	biolink:AnatomicalEntity	appendicular skeleton	Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm].	NCIT:C49477|VHOG:0001666|MIAA:0000278|MA:0000290|SCTID:322050006|UMLS:C0222646|VSAO:0000076|AAO:0000747|EMAPA:32729|Wikipedia:Appendicular_skeleton|XAO:0003166|EFO:0000951|MAT:0000278|FMA:71222	hp.json	entire appendicular skeleton|appendicular skeleton|paired fin skeleton|skeleton appendiculare|skeleton appendiculare|entire appendicular skeleton	http://purl.obolibrary.org/obo/UBERON_0002091		efo_slim|uberon_slim|vertebrate_core|pheno_slim
UBERON:0002094	biolink:AnatomicalEntity	interventricular septum	Cardiac septum which separates the right ventricle from the left ventricle.[FMA].	Wikipedia:Interventricular_septum|MA:0000085|OpenCyc:Mx4rwA7lp5wpEbGdrcN5Y29ycA|SCTID:362019005|VHOG:0000386|BTO:0002483|galen:InterventricularSeptum|EHDAA:2603|UMLS:C0225870|NCIT:C32874|EFO:0001956|EMAPA:17333|FMA:7133	hp.json	ventricle septum|ventricular septum|intraventricular septum|s. interventriculare cordis|heart ventricular septum|interventriculare cordis|intraventricular septum|septum inferius|septum membranaceum|septum inferius|septum membranaceum|ventricular septum|interventricular septum of heart|heart interventricular septum|s. interventriculare cordis	http://purl.obolibrary.org/obo/UBERON_0002094		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
HP:0006524	biolink:PhenotypicFeature	Tracheobronchial leiomyomatosis		UMLS:C3806786	hp.json		http://purl.obolibrary.org/obo/HP_0006524		
UBERON:0002093	biolink:AnatomicalEntity	spinal dura mater	A dura mater that is part of a spinal cord [Automatically generated definition].	EMAPA:17806|VHOG:0000411|UMLS:C0228124|SCTID:362302001|FMA:71237|MA:0001132|NCIT:C49799	hp.json	dura mater of neuraxis of spinal cord|spinal cord dura mater|spinal cord dura mater of neuraxis|dura mater of spinal cord	http://purl.obolibrary.org/obo/UBERON_0002093		pheno_slim|organ_slim
HP:0006525	biolink:PhenotypicFeature	obsolete Lung segmentation defects			hp.json		http://purl.obolibrary.org/obo/HP_0006525		
HP:0006520	biolink:PhenotypicFeature	Progressive pulmonary function impairment		UMLS:C1849570	hp.json		http://purl.obolibrary.org/obo/HP_0006520		
HP:0006521	biolink:PhenotypicFeature	Pulmonary lymphangiectasia	Abnormal dilatation of the pulmonary lymphatic vessels. Lymphatic fluid in the lung is derived from normal leakage of fluid out of the blood capillaries in the lung. In pulmonary lymphangiectasia, the pulmonary lymphatics are not properly connected and become dilated with fluid.	UMLS:C1855480	hp.json	Pulmonary lymphangiectasis	http://purl.obolibrary.org/obo/HP_0006521		
UBERON:0002099	biolink:AnatomicalEntity	cardiac septum	The thin membranous structure between the two heart atria or the thick muscular structure between the two heart ventricles.	UMLS:C0018819|MESH:D006346|MA:0000083|NCIT:C49485|EMAPA:35400|FMA:7180|SCTID:362014000|GAID:562	hp.json	heart septa|heart septum|septum of heart|spiral septa|cardiac septa	http://purl.obolibrary.org/obo/UBERON_0002099		pheno_slim|uberon_slim
CHEBI:23677	biolink:ChemicalSubstance	diazole	An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring.		hp.json	diazoles	http://purl.obolibrary.org/obo/CHEBI_23677		3_STAR
UBERON:0004660	biolink:AnatomicalEntity	mandible coronoid process	A dorsal process on the lower jaw associated with muscle attachment. It may be formed by a separate coronoid bone or as a process of the dentary. In most living (and many extinct) mammals, the most dorsal of the three proximal processes of the jaw.	FMA:52833|MA:0002819	hp.json	coronoid|coronoid process of mandible|mandibular coronoid process|processus coronoideus (mandibula)|processus coronoideus mandibulae	http://purl.obolibrary.org/obo/UBERON_0004660		pheno_slim
UBERON:2000238	biolink:AnatomicalEntity	olfactory tract linking bulb to ipsilateral ventral telencephalon		ZFA:0000238	hp.json		http://purl.obolibrary.org/obo/UBERON_2000238		
UBERON:0002005	biolink:AnatomicalEntity	enteric nervous system	The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gall bladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation[GO].	MAT:0000102|FMA:66070|EFO:0000895|TAO:0001155|EHDAA2:0004202|CALOHA:TS-2093|MIAA:0000102|BAMS:ENS|EMAPA:26922|UMLS:C0206111|GAID:799|BIRNLEX:1166|BTO:0002506|MA:0000222|MESH:D017615|ZFA:0001155	hp.json	enteric PNS|PNS - enteric	http://purl.obolibrary.org/obo/UBERON_0002005		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0004668	biolink:AnatomicalEntity	fourth ventricle aperture	One of: the 4th ventricle median or lateral apertures.	FMA:242766|MA:0002945	hp.json	aperture of 4th ventricle|aperture of fourth ventricle	http://purl.obolibrary.org/obo/UBERON_0004668		
UBERON:0002004	biolink:AnatomicalEntity	trunk of sciatic nerve		EMAPA:18577|FMA:65507|MA:0001178	hp.json	sciatic nerve trunk|sciatic neural trunk	http://purl.obolibrary.org/obo/UBERON_0002004		
UBERON:0004666	biolink:AnatomicalEntity	interventricular septum membranous part	The membranous portion of the wall between the two lower chambers of the heart.	MA:0002939|SCTID:278228007|EHDAA2:0004596|VHOG:0000927|EMAPA:18246|FMA:7135	hp.json	membranous septum|membranous part interventricular septum|membranous portion of interventricular septum|pars membranacea septi interventricularis|cardiac ventricular membranous septum|cardiac ventricular membranous septum|membranous part of interventricular septum|ventricle membranous septum|ventricular membranous septum|membranous interventricular septum|membranous interventricular septum|pars membranacea (septi interventricularis)	http://purl.obolibrary.org/obo/UBERON_0004666		pheno_slim
UBERON:0002007	biolink:AnatomicalEntity	medulla of lymph node	The medullary portion of the lymph node, which contains large blood vessels, sinuses and medullary cords that contain antibody-secreting plasma cells.	EMAPA:35529|MA:0000745|FMA:66254	hp.json	lymph node medulla|medulla nodi lymphoidei	http://purl.obolibrary.org/obo/UBERON_0002007		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0004667	biolink:AnatomicalEntity	interventricular septum muscular part	The muscular portion of the wall between the two lower chambers of the heart.	RETIRED_EHDAA2:0000888|EHDAA:2607|EMAPA:18247|MA:0002940|EHDAA2:0000885|FMA:7134	hp.json	pars muscularis (septi interventricularis)|muscular part of interventricular septum|muscular interventricular septum|septum membranaceum|pars muscularis septi interventricularis|cardiac ventricular muscular septum|muscular part interventricular septum|muscular septum|cardiac ventricular muscular septum|ventricular muscular septum|muscular interventricular septum	http://purl.obolibrary.org/obo/UBERON_0004667		pheno_slim
UBERON:0002006	biolink:AnatomicalEntity	cortex of lymph node	Peripheral portion of the lymph node, underneath the capsule[WP].	EMAPA:35525|UMLS:C0933402|FMA:66253|NCIT:C33029|MA:0000740	hp.json	cortex nodi lymphoidei|lymph node cortex	http://purl.obolibrary.org/obo/UBERON_0002006		pheno_slim|human_reference_atlas|uberon_slim
GO:0071764	biolink:BiologicalProcess	nuclear outer membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear outer membrane.		hp.json	nuclear outer membrane organisation|nuclear outer membrane organization and biogenesis	http://purl.obolibrary.org/obo/GO_0071764		
UBERON:0004664	biolink:AnatomicalEntity	aorta tunica adventitia	The outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers.	MA:0002902|EMAPA:35136|FMA:14283|SCTID:24996002	hp.json	tunica adventitia of aorta	http://purl.obolibrary.org/obo/UBERON_0004664		pheno_slim
UBERON:0002001	biolink:AnatomicalEntity	joint of rib	Any joint that connects a rib to another structure (or another rib). Examples: costochondral, costovertebral, interchondral, sternocostal joints.	MA:0001508|NCIT:C49575|FMA_RETIRED:64994|UMLS:C1261194	hp.json	rib joint	http://purl.obolibrary.org/obo/UBERON_0002001		
GO:0071763	biolink:BiologicalProcess	nuclear membrane organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane.		hp.json	nuclear membrane organization and biogenesis|nuclear membrane organisation	http://purl.obolibrary.org/obo/GO_0071763		
UBERON:0004665	biolink:AnatomicalEntity	muscular coat of seminal vesicle	A muscular coat that is part of a seminal vesicle [Automatically generated definition].	MA:0002913|FMA:19404|EMAPA:29773	hp.json	muscle layer of seminal vesicle|muscular coat of seminal gland|muscular layer of seminal gland|tunica muscularis glandulae vesiculosae|tunica muscularis (vesicula seminalis)	http://purl.obolibrary.org/obo/UBERON_0004665		
UBERON:0002000	biolink:AnatomicalEntity	gluteal muscle	On of the muscles that make up the buttocks: the gluteus maximus muscle, gluteus medius muscle and gluteus minimus muscle.	VHOG:0001316|BTO:0000531|UMLS:C1744702|EHDAA2:0000715|MA:0000535|NCIT:C78205|FMA:64922|EMAPA:18186	hp.json	gluteus|gluteus muscle	http://purl.obolibrary.org/obo/UBERON_0002000		pheno_slim|uberon_slim
UBERON:0004663	biolink:AnatomicalEntity	aorta wall	An anatomical wall that is part of an aorta, enclosing the luminal space.	EMAPA:35139|MA:0002901|FMA:14156	hp.json	aortic wall|wall of aorta	http://purl.obolibrary.org/obo/UBERON_0004663		pheno_slim
GO:0010819	biolink:BiologicalProcess	regulation of T cell chemotaxis	Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0010819		
GO:0010817	biolink:BiologicalProcess	regulation of hormone levels	Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.		hp.json		http://purl.obolibrary.org/obo/GO_0010817		
GO:0010818	biolink:BiologicalProcess	T cell chemotaxis	The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.		hp.json	T-cell chemotaxis	http://purl.obolibrary.org/obo/GO_0010818		
UBERON:0004649	biolink:AnatomicalEntity	sphenoid bone pterygoid process	The process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes.	MA:0002774|AAO:0010086|FMA:54682	hp.json	pterygoid process|processus pterygoideus ossis sphenoidalis|processus pterygoideus|pterygoid processes|pterygoid processus|pterygoid process of sphenoid bone|pterygoid process of sphenoid bone|pterygoid process|pterygoid process of sphenoid|pterygoid plate|processus pterygoideus ossis sphenoidalis	http://purl.obolibrary.org/obo/UBERON_0004649		pheno_slim
UBERON:0004650	biolink:AnatomicalEntity	tongue keratinized epithelium	A keratinized stratified squamous epithelium that is part of a tongue.	MA:0002787|FMA:74865	hp.json	keratinized epithelium of tongue	http://purl.obolibrary.org/obo/UBERON_0004650		
CHEBI:35664	biolink:ChemicalSubstance	EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor	Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.	PMID:15531285|PMID:1464741|PMID:20467214|Wikipedia:HMG-CoA_reductase	hp.json	hydroxymethylglutaryl-CoA reductase inhibitor|HMG-CoA reductase inhibitor|HMG-CoA reductase inhibitors|hydroxymethylglutaryl-CoA reductase inhibitors	http://purl.obolibrary.org/obo/CHEBI_35664		3_STAR
GO:0009820	biolink:BiologicalProcess	alkaloid metabolic process	The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).		hp.json	alkaloid metabolism	http://purl.obolibrary.org/obo/GO_0009820		goslim_chembl
GO:0009821	biolink:BiologicalProcess	alkaloid biosynthetic process	The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases).	UM-BBD_enzymeID:e0711	hp.json	alkaloid formation|alkaloid biosynthesis|alkaloid anabolism|alkaloid synthesis	http://purl.obolibrary.org/obo/GO_0009821		
UBERON:0004657	biolink:AnatomicalEntity	mandible condylar process	Articular part of the mandible bone.	GAID:219|MA:0002816|BTO:0001750|MESH:D008335|MFMO:0000056|FMA:52836|EMAPA:36572	hp.json	mandibular condyle|mandibular condyloid process|processus condylaris|condyle of mandible|condyle of the mandible|condyloid process|processus condylaris mandibulae|condyle of the mandible|condylar process of mandible	http://purl.obolibrary.org/obo/UBERON_0004657		pheno_slim
GO:0071754	biolink:CellularComponent	IgM immunoglobulin complex, circulating	A polymer of five or six IgM core units each composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds; the individual IgM core units are held together via disulfide bonds with a single J chain polypeptide acting as a bridge between two of the polymeric units. Circulating IgM is present in the extracellular space, in mucosal areas or other tissues, or in the blood or lymph.		hp.json	IgM antibody	http://purl.obolibrary.org/obo/GO_0071754		
GO:0071753	biolink:CellularComponent	IgM immunoglobulin complex	A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.		hp.json		http://purl.obolibrary.org/obo/GO_0071753		
UBERON:0004652	biolink:AnatomicalEntity	humerus diaphysis	The body or shaft of the humerus is almost cylindrical in the upper half of its extent, prismatic and flattened below, and has three borders and three surfaces.	MA:0002807|FMA:13305|NCIT:C120671|EMAPA:25051	hp.json	body of the humerus|diaphysis of humerus|corpus humeri|shaft of humerus|shaft of the humerus|humeral diaphysis|body of humerus|medial humerus	http://purl.obolibrary.org/obo/UBERON_0004652		pheno_slim
UBERON:0004639	biolink:AnatomicalEntity	renal afferent arteriole	The blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism.	MA:0002579|FMA:77042|TAO:0002139|EMAPA:28266|EMAPA:28230|ZFA:0005307	hp.json	afferent arteriole|afferent glomerular arteriole|kidney afferent arteriole|arteriola glomerularis afferens renis|arteriola glomerularis afferens|afferent glomerular arteriole of kidney	http://purl.obolibrary.org/obo/UBERON_0004639		vertebrate_core|pheno_slim|human_reference_atlas
UBERON:0004637	biolink:AnatomicalEntity	otic capsule	The capsule surrounding the inner ear mechanism.	VHOG:0000854|AAO:0010143	hp.json	otic region|otic capsule|auditory capsule|periotic capsule|otic capsule endochondral element|otic capsule skeletal element|periotic|otic capsule element	http://purl.obolibrary.org/obo/UBERON_0004637		
UBERON:0004638	biolink:AnatomicalEntity	blood vessel endothelium	An endothelium that lines the blood vasculature. Other endothelia may line lymph vessels, the heart.	UMLS:C1706972|EMAPA:35176|CALOHA:TS-2155|ZFA:0005257|MA:0000709|BTO:0000766|NCIT:C53395|TAO:0005257	hp.json		http://purl.obolibrary.org/obo/UBERON_0004638		vertebrate_core|pheno_slim
UBERON:0004646	biolink:AnatomicalEntity	infraorbital artery	The infraorbital artery is an artery in the head that runs in the maxilla, emerging through the infraorbital foramen, just under the orbit of the eye. [WP,unvetted].	EMAPA:37090|FMA:49767|MA:0001977|UMLS:C0226153|NCIT:C52940	hp.json	a. infraorbitalis|infra-orbital artery	http://purl.obolibrary.org/obo/UBERON_0004646		human_reference_atlas
UBERON:0004647	biolink:AnatomicalEntity	liver lobule	The polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein.	UMLS:C0227518|FMA:14471|MA:0002494|EMAPA:35499|NCIT:C32732	hp.json	lobules of liver|lobuli hepatici|lobulus hepaticus|hepatic lobule|lobuli hepatis	http://purl.obolibrary.org/obo/UBERON_0004647		pheno_slim|human_reference_atlas
UBERON:0004641	biolink:AnatomicalEntity	spleen capsule	The connective tissue that surrounds the spleen.	FMA:15849|EMAPA:35802|UMLS:C0229681|MA:0000753|NCIT:C33598	hp.json	tunica fibrosa splenica|Malpighian capsule|splenic capsule|fibrous capsule of spleen|fibroelastic coat of spleen|capsula splenica|tunica fibrosa (splen)(lien)|capsule of spleen	http://purl.obolibrary.org/obo/UBERON_0004641		pheno_slim|human_reference_atlas
UBERON:0004628	biolink:AnatomicalEntity	thoracic vertebra 3	The third thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	NCIT:C33725|UMLS:C0459952|EMAPA:19544|MA:0001440|FMA:9209	hp.json	third thoracic vertebra|T3 vertebra|third dorsal vertebra	http://purl.obolibrary.org/obo/UBERON_0004628		defined_by_ordinal_series
UBERON:0004629	biolink:AnatomicalEntity	thoracic vertebra 4	The fourth thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	EMAPA:19545|UMLS:C0459951|FMA:9248|MA:0001441|NCIT:C33726	hp.json	T4 vertebra|fourth thoracic vertebra|fourth dorsal vertebra	http://purl.obolibrary.org/obo/UBERON_0004629		defined_by_ordinal_series
UBERON:0004626	biolink:AnatomicalEntity	thoracic vertebra 1	The first thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	UMLS:C0459933|NCIT:C33720|EMAPA:19542|FMA:9165|MA:0001438	hp.json	first dorsal vertebra|T1 vertebra|first thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0004626		defined_by_ordinal_series
UBERON:0004627	biolink:AnatomicalEntity	thoracic vertebra 2	The second thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	NCIT:C33724|EMAPA:19543|FMA:9187|MA:0001439|UMLS:C0459936	hp.json	T2 vertebra|second thoracic vertebra|second dorsal vertebra	http://purl.obolibrary.org/obo/UBERON_0004627		defined_by_ordinal_series
UBERON:0016612	biolink:AnatomicalEntity	auditory hillocks, pharyngeal arch 2 derived	A collection of protruberances derived from pharyngeal arch 2 that develop into the concha, antihelix and antitragus.		hp.json		http://purl.obolibrary.org/obo/UBERON_0016612		
UBERON:0016611	biolink:AnatomicalEntity	auditory hillocks, pharyngeal arch 1 derived	A collection of protruberances derived from pharyngeal arch 1 that develop into the tragus, crus of the helix, and helix.		hp.json		http://purl.obolibrary.org/obo/UBERON_0016611		
UBERON:0004635	biolink:AnatomicalEntity	thoracic vertebra 11	The eleventh thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	NCIT:C33722|EMAPA:19552|FMA:10059|MA:0001448|UMLS:C0459956	hp.json	eleventh thoracic vertebra|eleventh dorsal vertebra|T11 vertebra	http://purl.obolibrary.org/obo/UBERON_0004635		defined_by_ordinal_series
UBERON:0004636	biolink:AnatomicalEntity	thoracic vertebra 12	The twelfth thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	EMAPA:19553|FMA:10081|MA:0001449|UMLS:C0459957|NCIT:C33723	hp.json	T12 vertebra|twelfth dorsal vertebra|twelfth thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0004636		defined_by_ordinal_series
UBERON:0004633	biolink:AnatomicalEntity	thoracic vertebra 9	The ninth thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	NCIT:C33731|EMAPA:19550|UMLS:C0459954|FMA:10014|MA:0001446	hp.json	Ninth dorsal vertebra|T9 vertebra|ninth thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0004633		defined_by_ordinal_series
UBERON:0004634	biolink:AnatomicalEntity	thoracic vertebra 10	The tenth thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	NCIT:C33721|UMLS:C0459955|EMAPA:19551|FMA:10037|MA:0001447	hp.json	tenth thoracic vertebra|T10 vertebra|tenth dorsal vertebra	http://purl.obolibrary.org/obo/UBERON_0004634		defined_by_ordinal_series
UBERON:0004631	biolink:AnatomicalEntity	thoracic vertebra 6	The sixth thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	MA:0001443|UMLS:C0459949|NCIT:C33728|FMA:9945|EMAPA:19547	hp.json	sixth dorsal vertebra|T6 vertebra|sixth thoracic vertebra	http://purl.obolibrary.org/obo/UBERON_0004631		defined_by_ordinal_series
UBERON:0004632	biolink:AnatomicalEntity	thoracic vertebra 7	The seventh thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	UMLS:C0459947|NCIT:C33729|FMA:9968|EMAPA:19548|MA:0001444	hp.json	seventh thoracic vertebra|T7 vertebra|seventh dorsal vertebra	http://purl.obolibrary.org/obo/UBERON_0004632		defined_by_ordinal_series
CHEBI:3892	biolink:ChemicalSubstance	corticotropin	A polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency.	Drug_Central:4931|DrugBank:DB01285|KEGG:C02017|KEGG:D00146|CAS:9002-60-2|CAS:9002-60-2	hp.json	Corticotropin|corticotrophine|Adrenocorticotropic hormone|corticotropin|L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-alpha-aspartylglycyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-alpha-glutamyl-L-seryl-L-alanyl-L-alpha-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-alpha-glutamyl-L-phenylalanine|cortrophin|ACTH|SYSMEHFRWGKPVGKKRRPVKVYPDGAEDQLAEAFPLEF|corticotrofina|adrenocorticotropin|corticotrophinum	http://purl.obolibrary.org/obo/CHEBI_3892		3_STAR
UBERON:0004630	biolink:AnatomicalEntity	thoracic vertebra 5	The fifth thoracic vertebra counting from the top down. Note that members of this class are not necessarily homologous[ncit,modified].	MA:0001442|NCIT:C33727|FMA:9922|EMAPA:19546|UMLS:C0459950	hp.json	fifth thoracic vertebra|fifth dorsal vertebra|T5 vertebra	http://purl.obolibrary.org/obo/UBERON_0004630		defined_by_ordinal_series
CHEBI:35618	biolink:ChemicalSubstance	aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.		hp.json		http://purl.obolibrary.org/obo/CHEBI_35618		3_STAR
CHEBI:35617	biolink:ChemicalSubstance	flavouring agent	A food additive that is used to added improve the taste or odour of a food.		hp.json	flavour enhancer|flavour enhancers|flavouring agents|flavoring agents|flavoring agent	http://purl.obolibrary.org/obo/CHEBI_35617		3_STAR
UBERON:0002040	biolink:AnatomicalEntity	bronchial artery	A systemic artery that supplies the lung with with oxygenated blood.	GAID:477|UMLS:C0006257|SCTID:244247009|Wikipedia:Bronchial_artery|OpenCyc:Mx4r4sy0UiNbEd2AAAACs6hRXg|FMA:68109|MESH:D001981|NCIT:C32230|EMAPA:18608|MA:0001923	hp.json	arteriae bronchiales|arteriae bronchiales|bronchial arterial tree|rami bronchiales partis thoracicae aortae|rami bronchiales partis thoracicae aortae	http://purl.obolibrary.org/obo/UBERON_0002040		human_reference_atlas|uberon_slim
CHEBI:35610	biolink:ChemicalSubstance	antineoplastic agent	A substance that inhibits or prevents the proliferation of neoplasms.		hp.json	cytostatic|anticancer agents|antineoplastic|anticancer agent|antineoplastic agents	http://purl.obolibrary.org/obo/CHEBI_35610		3_STAR
UBERON:0002042	biolink:AnatomicalEntity	lymphatic vessel endothelium	An endothelium that is part of a lymphatic vessel [Automatically generated definition].	MESH:D004729|UMLS:C1180786|CALOHA:TS-2156|MA:0000750|ZFA:0005258|TAO:0005258|NCIT:C49258|BTO:0004303|EMAPA:35533|FMA:68444	hp.json	lymph vessel endothelium|endothelium of lymphatic vessel|endothelium of lymph vessel|lymphatic endothelium|lymphatic vessel endothelium	http://purl.obolibrary.org/obo/UBERON_0002042		vertebrate_core|pheno_slim|human_reference_atlas
UBERON:0002049	biolink:AnatomicalEntity	vasculature	An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face.	BTO:0003718|ZFA:0005249|TAO:0005249|FMA:69050	hp.json	vascular network	http://purl.obolibrary.org/obo/UBERON_0002049		uberon_slim|vertebrate_core|pheno_slim|human_reference_atlas
UBERON:0002048	biolink:AnatomicalEntity	lung	Respiration organ that develops as an outpocketing of the esophagus.	MA:0000415|MESH:D008168|VHOG:0000310|galen:Lung|GAID:345|OpenCyc:Mx4rvVjKy5wpEbGdrcN5Y29ycA|EHDAA:2205|EFO:0000934|EHDAA:1554|NCIT:C12468|AAO:0010567|UMLS:C0024109|SCTID:181216001|MAT:0000135|EMAPA:16728|BTO:0000763|FMA:7195|AAO:0000275|CALOHA:TS-0568|Wikipedia:Lung|MIAA:0000135|XAO:0000119|EHDAA2:0001042|EV:0100042	hp.json	pulmo	http://purl.obolibrary.org/obo/UBERON_0002048		uberon_slim|major_organ|organ_slim|pheno_slim|efo_slim|human_reference_atlas
CHEBI:23639	biolink:ChemicalSubstance	deoxy sugar	Any sugar having a hydroxy group replaced with a hydrogen atom.		hp.json	deoxy sugars|deoxysugars|deoxysugar	http://purl.obolibrary.org/obo/CHEBI_23639		3_STAR
UBERON:0002047	biolink:AnatomicalEntity	pontine raphe nucleus	The pontine raphe nucleus is one of the raphe nuclei. It is located in the pontine tegmentum. [WP,unvetted].	UMLS:C0175423|HBA:9159|BAMS:PnR|BAMS:RA-PONS|BIRNLEX:1110|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=589|BAMS:RPn|Wikipedia:Pontine_raphe_nucleus|DHBA:12475|MBA:238|MA:0001022|DHBA:12471|FMA:68875	hp.json	raphe pontis|nucleus raphes pontis|raphe (mediana pontina)|nucleus raphes pontis|nucleus raphe pontis|raphe pontis nucleus|raphe of pons	http://purl.obolibrary.org/obo/UBERON_0002047		uberon_slim|pheno_slim
UBERON:0002046	biolink:AnatomicalEntity	thyroid gland	A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO].	MA:0000129|UMLS:C0040132|CALOHA:TS-1047|FMA:9603|MAT:0000081|EHDAA:2975|GAID:465|EMAPA:17068|EHDAA:2148|AAO:0010544|EHDAA2:0002028|VHOG:0000418|MIAA:0000081|NCIT:C12400|XAO:0000162|MESH:D013961|BTO:0001379|EV:0100133|EFO:0000861|OpenCyc:Mx4rvVjLT5wpEbGdrcN5Y29ycA|galen:ThyroidGland	hp.json	glandula thyroidea|thyroid	http://purl.obolibrary.org/obo/UBERON_0002046		uberon_slim|organ_slim|pheno_slim|efo_slim
UBERON:0002030	biolink:AnatomicalEntity	nipple	Projection of skin containing the outlets for 15-20 lactiferous ducts arranged cylindrically around the tip.	FMA:67771|OpenCyc:Mx4rvVjKi5wpEbGdrcN5Y29ycA|CALOHA:TS-2234|MA:0000796|BTO:0000821|EMAPA:36508|NCIT:C12299|GAID:35|MESH:D009558|UMLS:C0028109|galen:Nipple	hp.json	papillary part of breast|thelium|papilla of breast|papilla mammae|teat|papilla mammaria|thele	http://purl.obolibrary.org/obo/UBERON_0002030		uberon_slim|pheno_slim
CHEBI:35621	biolink:ChemicalSubstance	alpha-aminobutyric acid	An alpha-amino acid that is butyric acid bearing a single amino substituent located at position 2.	Reaxys:635889|DrugBank:DB04454|PMID:22264337|CAS:2835-81-6|PMID:22770225|PMID:11958629|MetaCyc:CPD-3686|Gmelin:217679|PMID:22061039|PMID:15246869|Beilstein:635889|CAS:2835-81-6|Wikipedia:Alpha-Aminobutyric_acid|PMID:20551690	hp.json	homoalanine|alpha-amino-n-butyric acid|butyrine|2-amino-n-butyric acid|AABA|alpha-aminobutyric acid|Abu|2-aminobutyric acid|2-aminobutanoic acid	http://purl.obolibrary.org/obo/CHEBI_35621		3_STAR
UBERON:0002032	biolink:AnatomicalEntity	areola	Subdivision of breast which consists of skin, connective tissue and smooth muscle bundle and modified sebaceous glands and which surrounds the nipple.	OpenCyc:Mx4rvrcOL5wpEbGdrcN5Y29ycA|FMA:67796|UMLS:C0222608|MA:0000788|NCIT:C12368	hp.json	areola mammae|areolae	http://purl.obolibrary.org/obo/UBERON_0002032		uberon_slim|pheno_slim
GO:0140131	biolink:BiologicalProcess	positive regulation of lymphocyte chemotaxis	Any process that activates or increases the frequency, rate or extent of lymphocyte chemotaxis.		hp.json		http://purl.obolibrary.org/obo/GO_0140131		
UBERON:0002031	biolink:AnatomicalEntity	epithelium of bronchus	An epithelium that is part of a bronchus [Automatically generated definition].	FMA:67782|EMAPA:32691|EFO:0000307|BTO:0001845|UMLS:C0599333|CALOHA:TS-1240|NCIT:C32231|MA:0001839	hp.json	epithelium of bronchial trunk|bronchi epithelium|epithelial tissue of bronchi|epithelial tissue of bronchial trunk|bronchi epithelial tissue|bronchial trunk epithelial tissue|bronchus epithelial tissue|bronchial epithelium|bronchus epithelium|epithelial tissue of bronchus|epithelium of bronchi|bronchial trunk epithelium	http://purl.obolibrary.org/obo/UBERON_0002031		pheno_slim|efo_slim
CHEBI:35620	biolink:ChemicalSubstance	vasodilator agent	A drug used to cause dilation of the blood vessels.		hp.json	vasodilator agents|vasodilator	http://purl.obolibrary.org/obo/CHEBI_35620		3_STAR
UBERON:0004692	biolink:AnatomicalEntity	external naris epithelium	An epithelium that is part of an external naris [Automatically generated definition].	MA:0001321|EMAPA:18596	hp.json		http://purl.obolibrary.org/obo/UBERON_0004692		
CHEBI:35623	biolink:ChemicalSubstance	anticonvulsant	A drug used to prevent seizures or reduce their severity.		hp.json	anti-convulsive agent|antiepileptics|anticonvulsive agents|anti-convulsant|anti-convulsants|anticonvulsive agent|Antiepileptika|Antikonvulsiva|Antiepileptikum|antiepileptic|Antikonvulsivum|anti-convulsive agents|anticonvulsants|antiepileptiques|antiepileptique	http://purl.obolibrary.org/obo/CHEBI_35623		3_STAR
UBERON:0002038	biolink:AnatomicalEntity	substantia nigra	Predominantly gray matter midbrain structure lying dorsal to the crus cerebri and ventral to the midbrain tegmentum. It is divided into a dorsal, cellularly compact region known as the pars compacta and a more ventrally located, containing more loosely packed cells, the pars reticulata. The most lateral region of the reticulata is identified as the pars lateralis (MM).	UMLS:C0038590|HBA:9072|BTO:0000143|UMLS:C0038590|BAMS:SN|VHOG:0001573|UMLS:C1269578|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=536|MAT:0000504|CALOHA:TS-0990|EFO:0000922|MA:0000210|EV:0100247|FMA:67947|BIRNLEX:789|EHDAA2:0004711|MESH:D013378|GAID:581|NCIT:C12453|EMAPA:35835|DHBA:12251	hp.json	nucleus pigmentosus subthalamo-peduncularis|SN|substancia nigra|nucleus of basis pedunculi|substantia nigra (Soemmerringi)|Soemmering's substance	http://purl.obolibrary.org/obo/UBERON_0002038		human_reference_atlas|efo_slim|uberon_slim|pheno_slim
UBERON:0002037	biolink:AnatomicalEntity	cerebellum	Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA].	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=643|BAMS:CB|BAMS:Cb|UMLS:C0007765|BTO:0000232|OpenCyc:Mx4rvl1eipwpEbGdrcN5Y29ycA|HBA:4696|MIAA:0000110|BIRNLEX:1489|EV:0100293|CALOHA:TS-0125|VHOG:0000024|DHBA:10656|EMAPA:17787|BM:CB|EFO:0000327|GAID:595|ZFA:0000100|NCIT:C12445|MA:0000198|TAO:0000100|MBA:512|XAO:0003098|EHDAA2:0000232|FMA:67944|MESH:D002531|AAO:0010485|MAT:0000110|UMLS:C0007765|UMLS:C1268981	hp.json	epencephalon-1|infratentorial region|parencephalon|corpus cerebelli	http://purl.obolibrary.org/obo/UBERON_0002037		efo_slim|human_reference_atlas|uberon_slim|vertebrate_core|pheno_slim
UBERON:0004699	biolink:AnatomicalEntity	outflow tract endothelium	An endothelium that is part of a outflow tract [Automatically generated definition].	VHOG:0001524|MA:0000490	hp.json		http://purl.obolibrary.org/obo/UBERON_0004699		
UBERON:0004698	biolink:AnatomicalEntity	vena cava endothelium	An endothelium that is part of a vena cava [Automatically generated definition].	MA:0000713|NCIT:C49318|EMAPA:37800|UMLS:C1710623	hp.json		http://purl.obolibrary.org/obo/UBERON_0004698		
UBERON:0002033	biolink:AnatomicalEntity	arrector muscle of hair	A tiny smooth muscle that connects the hair follicle with the dermis.	MA:0000778|EMAPA:26775|BTO:0005132|FMA:67821	hp.json	arrector pili smooth muscle|erector pili|arectores pilorum|arrector pili muscle|arrector pilli muscle|arrector pilli|arrector pili|pilomotor muscle|erectores pilorum|arrector pilorum|arrector pilorum muscle of hair	http://purl.obolibrary.org/obo/UBERON_0002033		uberon_slim|pheno_slim
UBERON:0002036	biolink:AnatomicalEntity	striated muscle tissue	Muscle tissue that contains fibers that are divided by transverse bands into striations.	UMLS:C1331262|Wikipedia:Striated_muscle|EHDAA2:0003140|MA:0002438|CALOHA:TS-2047|AEO:0000140|FMA:67905|NCIT:C12436|galen:StriatedMuscle|AAO:0010762|OpenCyc:Mx4rwAoze5wpEbGdrcN5Y29ycA|WBbt:0005779|EMAPA:36390	hp.json	striated muscle	http://purl.obolibrary.org/obo/UBERON_0002036		uberon_slim|pheno_slim
UBERON:0004695	biolink:AnatomicalEntity	arterial system smooth muscle	A portion of smooth muscle tissue that is part of an arterial system [Automatically generated definition].	MA:0000704|EMAPA:36503	hp.json		http://purl.obolibrary.org/obo/UBERON_0004695		human_reference_atlas
UBERON:0004696	biolink:AnatomicalEntity	venous system smooth muscle	A portion of smooth muscle tissue that is part of a venous system [Automatically generated definition].	MA:0000715|EMAPA:36613	hp.json		http://purl.obolibrary.org/obo/UBERON_0004696		human_reference_atlas
UBERON:0002019	biolink:AnatomicalEntity	accessory XI nerve	A cranial nerve that originates from neurons in the medulla and in the cervical spinal cord.	http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2085|HBA:9340|MA:0001088|AAO:0010476|BAMS:11n|BAMS:XIn|MESH:D000055|GAID:825|VHOG:0000699|FMA:80284|NCIT:C32041|SCTID:362469008|MBA:717|EHDAA:2855|FMA:6720|UMLS:C0000905|Wikipedia:Spinal_accessory_nerve|EHDAA2:0000106|UMLS:C1305777|XAO:0004214|OpenCyc:Mx4rwTEwI5wpEbGdrcN5Y29ycA|UMLS:C0000905|BIRNLEX:812|EMAPA:17265	hp.json	accessory spinal nerve|CN-XI|accessory XI nerve|cervical accessory nerve|cranial nerve XI|accessory nerve [XI]|Willis' nerve|spinal accessory nerve tree|accessory XI|nervus accessorius [XI]|radix spinalis nervus accessorius|eleventh cranial nerve|spinal part of accessory nerve|pars spinalis nervus accessorius|accessory nerve|spinal accessory nerve	http://purl.obolibrary.org/obo/UBERON_0002019		pheno_slim|uberon_slim
UBERON:0002020	biolink:AnatomicalEntity	gray matter	A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons.	AEO:0001012|FMA:67242|MESH:D066128|MA:0001112|NCIT:C32695|Wikipedia:Gray_matter|OpenCyc:Mx4rwDdKMpwpEbGdrcN5Y29ycA|ZFA:0001681|UMLS:C0018220|VHOG:0001768|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2869|EHDAA2:0003136|EHDAA2_RETIRED:0004658|HBA:4006|EMAPA:37596|TAO:0002197	hp.json	gray mater|grey matter|neuronal grey matter|grey matter of neuraxis|grisea|grey substance|gray matter of neuraxis|gray matter|substantia grisea	http://purl.obolibrary.org/obo/UBERON_0002020		uberon_slim|vertebrate_core|pheno_slim
UBERON:0004681	biolink:AnatomicalEntity	vestibular system	The sensory system for the sense of balance.	BTO:0003381|NLXANAT:090819|EMAPA:37986|FMA:7193	hp.json	vestibulomotor system|vestibular organ system|vestibular system|equilibrioception system	http://purl.obolibrary.org/obo/UBERON_0004681		pheno_slim
UBERON:0002027	biolink:AnatomicalEntity	stratum corneum of epidermis	The outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells.	EMAPA:32787|BTO:0000344|MA:0000804|FMA:67545|UMLS:C0221921|NCIT:C33625|CALOHA:TS-0981|AAO:0010597	hp.json	horny layer|keratinized squame layer|keratinized squame layer of epidermis|stratum corneum|stratum corneum epidermidis|epidermis stratum corneum|cornified layer|horny layer of epidermis	http://purl.obolibrary.org/obo/UBERON_0002027		human_reference_atlas|pheno_slim
UBERON:0002026	biolink:AnatomicalEntity	stratum spinosum of epidermis	The layer of polyhedral cells in the epidermis found between the stratum granulosum and stratum basale; shrinkage and adhesion of these cells gives a spiny or prickly appearance.	EMAPA:32785|FMA:67542|UMLS:C0221924|MA:0000807|BTO:0000435|NCIT:C12850	hp.json	Malpighian layer|squamous cell layer of epidermis|stratum spinosum|epidermis prickle cell layer|prickle cell layer of epidermis|prickle cell layer|stratum Malpighii|epidermis stratum spinosum	http://purl.obolibrary.org/obo/UBERON_0002026		human_reference_atlas|pheno_slim
UBERON:0002029	biolink:AnatomicalEntity	epithelium of gall bladder	The simple columnar epithelial lining of the gall bladder.	UMLS:C1180206|FMA:67711|CALOHA:TS-1304|MA:0001632|BTO:0001449|EMAPA:35370|NCIT:C49227	hp.json	gall bladder epithelial tissue|epithelial tissue of gallbladder|gallbladder epithelial tissue|epithelial tissue of gall bladder|biliary epithelium|gallbladder epithelium|gall bladder epithelium|epithelium of gallbladder	http://purl.obolibrary.org/obo/UBERON_0002029		pheno_slim
UBERON:0004688	biolink:AnatomicalEntity	costo-cervical trunk	The costocervical trunk arises from the upper and back part of the subclavian artery, behind the scalenus anterior on the right side, and medial to that muscle on the left side. Passing backward, it splits into the deep cervical artery and the supreme intercostal artery (or the Highest intercostal artery), which descends behind the pleura in front of the necks of the first and second ribs, and anastomoses with the first aortic intercostal (3rd posterior intercostal artery). As it crosses the neck of the first rib it lies medial to the anterior division of the first thoracic nerve, and lateral to the first thoracic ganglion of the sympathetic trunk. In the first intercostal space, it gives off a branch which is distributed in a manner similar to the distribution of the aortic intercostals. The branch for the second intercostal space usually joins with one from the highest aortic intercostal artery. This branch is not constant, but is more commonly found on the right side; when absent, its place is supplied by an intercostal branch from the aorta. Each intercostal gives off a posterior branch which goes to the posterior vertebral muscles, and sends a small spinal branch through the corresponding intervertebral foramen to the medulla spinalis and its membranes. [WP,unvetted].	EMAPA:37496|Wikipedia:Costocervical_trunk|SCTID:244225009|FMA:10636|MA:0001939	hp.json	truncus costocervicalis|trunk of costocervical artery|costocervical trunk|truncus costocervicalis	http://purl.obolibrary.org/obo/UBERON_0004688		human_reference_atlas
UBERON:0002028	biolink:AnatomicalEntity	hindbrain	The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA].	MA:0000195|EHDAA:6487|FMA:67687|BTO:0000672|CALOHA:TS-0457|UMLS:C1522180|ZFA:0000029|AAO:0010150|NCIT:C40336|XAO:0000015|EHDAA2:0000746|BAMS:HB|TAO:0000029|EHDAA:3514|UMLS:C0035507|MAT:0000107|DHBA:10653|EFO:0000923|SCTID:303456008|MESH:D012249|MBA:1065|MIAA:0000107|BIRNLEX:942|DMBA:16808|VHOG:0000070|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=540|EMAPA:16916|UMLS:C0035507|Wikipedia:Rhombencephalon	hp.json	rhombencephalon	http://purl.obolibrary.org/obo/UBERON_0002028		pheno_slim|human_reference_atlas|efo_slim|uberon_slim|vertebrate_core
UBERON:0002025	biolink:AnatomicalEntity	stratum basale of epidermis	The deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells.	MA:0000803|ZFA:0001180|FMA:67540|TAO:0001180|NCIT:C33623|BTO:0000438|Wikipedia:Stratum_germinativum|NCIT:C33466|EMAPA:32779|AAO:0010598|SCTID:419481005|XAO:0000041|UMLS:C0221925	hp.json	Malpighian layer|stratum basalis of epidermis|stratum Malpighi|epidermis stratum basale|basal layer of epidermis|basal cell layer of skin|basal epidermal layer|stratum germinosum|epidermis sensorial layer|epidermal basal stratum|Malpighian layer|epidermis stratum germinativum|epidermis basal layer|stratum basale|stratum germinosum of epidermis|rete Malphighii|rete Malpighii|stratum germinativum|basal cell layer of epidermis|stratum Malpighi	http://purl.obolibrary.org/obo/UBERON_0002025		human_reference_atlas|uberon_slim|pheno_slim
UBERON:0004684	biolink:AnatomicalEntity	raphe nuclei	The raphe nuclei are thin plates of cells in and immediately adjacent to the sagittal plane.	EMAPA:35721|BAMS:RA|MESH:D011903|TAO:0001429|UMLS:C0034671|NCIT:C97335|NLXANAT:20090205|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2495|MA:0003147|FMA:84017|Wikipedia:Raphe_nuclei|ZFA:0001429	hp.json	set of raphe nuclei|raphe cluster|nuclei raphes|raphe nuclei set|nuclei raphes|raphe nuclei|nuclei raphes|raphe of mesenchephalon|raphe cluster|raphe nuclei|raphe nucleus	http://purl.obolibrary.org/obo/UBERON_0004684		vertebrate_core
UBERON:0002008	biolink:AnatomicalEntity	cardiac nerve plexus	A plexus of nerves situated at the base of the heart that innervate the heart.	FMA:6628|NCIT:C52833|UMLS:C0459528|EMAPA:37460|MA:0001138	hp.json	autonomic plexus of heart|heart autonomic nerve plexus|plexus cardiacus|autonomic nerve plexus of heart|cardiac plexus|heart autonomic plexus	http://purl.obolibrary.org/obo/UBERON_0002008		uberon_slim
CHEBI:23622	biolink:ChemicalSubstance	deoxygalactose			hp.json	deoxygalactoses|deoxygalactose	http://purl.obolibrary.org/obo/CHEBI_23622		3_STAR
CHEBI:35605	biolink:ChemicalSubstance	carbon oxoacid			hp.json	carbon oxoacids|oxoacids of carbon	http://purl.obolibrary.org/obo/CHEBI_35605		3_STAR
CHEBI:35604	biolink:ChemicalSubstance	carbon oxoanion	A negative ion consisting solely of carbon and oxygen  atoms, and therefore having the general formula CxOy(n-) for some integers x, y and n.		hp.json	oxocarbon anion|carbon oxoanion|carbon oxoanions|oxocarbon anions	http://purl.obolibrary.org/obo/CHEBI_35604		3_STAR
UBERON:0002016	biolink:AnatomicalEntity	pulmonary vein	Pulmonary veins are blood vessels that transport blood from the lungs to the heart[GO].	galen:PulmonaryVein|FMA:66643|EHDAA:2629|Wikipedia:Pulmonary_vein|CALOHA:TS-0840|EMAPA:18645|VHOG:0001133|MA:0002206|GAID:543|MESH:D011667|EHDAA2:0001579|SCTID:430160002|NCIT:C12776|UMLS:C0034090|AAO:0010521|XAO:0000394|BTO:0001799	hp.json	venae pulmonales|pulmonary venous tree organ part|venae pulmonales	http://purl.obolibrary.org/obo/UBERON_0002016		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0004679	biolink:AnatomicalEntity	dentate gyrus molecular layer	The molecular layer of the dentate gyrus that is bounded by the pial surface superficially and the dentate gyrus granule cell layer deep. It is divided into 2 or more sublayers.	MA:0003122|BAMS:mo|BAMS:Mol|EMAPA:35279|BIRNLEX:4127|MBA:10703|FMA:83677	hp.json	molecular layer of the dentate gyrus|molecular layer of dentate gyrus|stratum moleculare gyri dentati|dentate gyrus molecular layer	http://purl.obolibrary.org/obo/UBERON_0004679		
UBERON:0002015	biolink:AnatomicalEntity	kidney capsule	The tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage.	MA:0000370|FMA:66610|galen:CapsuleOfKidney|EMAPA:18679|UMLS:C0227637|NCIT:C12885	hp.json	fibrous capsule of kidney|capsule of kidney|renal capsule|capsula fibrosa renis	http://purl.obolibrary.org/obo/UBERON_0002015		pheno_slim|human_reference_atlas|uberon_slim
SO:0001217	biolink:SequenceFeature	protein_coding_gene			hp.json	protein coding gene	http://purl.obolibrary.org/obo/SO_0001217		
CHEBI:23628	biolink:ChemicalSubstance	deoxyhexose	Any C6 deoxy sugar having at least one hydroxy group replaced by hydrogen.		hp.json	deoxyhexoses|deoxyhexose	http://purl.obolibrary.org/obo/CHEBI_23628		3_STAR
UBERON:0002017	biolink:AnatomicalEntity	portal vein	A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO].	CALOHA:TS-0814|NCIT:C33343|XAO:0000392|MA:0002198|EHDAA2:0001485|EHDAA:6510|FMA:66645|VHOG:0000656|OpenCyc:Mx4rv_bem5wpEbGdrcN5Y29ycA|UMLS:C0032718|BTO:0001792|EMAPA:17349|galen:PortalVein|GAID:540|MESH:D011169	hp.json	portal venous tree organ part	http://purl.obolibrary.org/obo/UBERON_0002017		pheno_slim|uberon_slim
UBERON:0002012	biolink:AnatomicalEntity	pulmonary artery	An artery that carries deoxygenated blood from heart to the lungs. They are the only arteries (other than umbilical arteries in the fetus) that carry deoxygenated blood..	EFO:0001399|MA:0002031|XAO:0004162|GAID:505|EHDAA:4351|VHOG:0000982|EMAPA:17008|OpenCyc:Mx4rvVjbIpwpEbGdrcN5Y29ycA|galen:PulmonaryArtery|CALOHA:TS-0839|UMLS:C0034052|BTO:0000778|NCIT:C12774|EHDAA2:0001575|MESH:D011651|Wikipedia:Pulmonary_artery|AAO:0010221|SCTID:181380003|FMA:66326	hp.json	pulmonary arterial tree|arteria pulmonalis|pulmonary arterial subtree|truncus pulmonalis|arteria pulmonalis|pulmonary arterial tree organ part|truncus pulmonalis	http://purl.obolibrary.org/obo/UBERON_0002012		efo_slim|uberon_slim|pheno_slim
UBERON:0002011	biolink:AnatomicalEntity	thoracodorsal artery	The thoracodorsal artery is a branch of the subscapular artery. It travels inferiorly with the thoracodorsal nerve and supplies the latissimus dorsi. [WP,unvetted].	FMA:66320|NCIT:C53018|EMAPA:37129|UMLS:C0933449|MA:0002065	hp.json	arteria thoracodorsalis	http://purl.obolibrary.org/obo/UBERON_0002011		human_reference_atlas|uberon_slim
GO:0007350	biolink:BiologicalProcess	blastoderm segmentation	The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.		hp.json		http://purl.obolibrary.org/obo/GO_0007350		
HP:0041060	biolink:PhenotypicFeature	Chronic partially decreased circulating IgG4	A lasting limited decrease of immunoglobulin G4 (IgG4) in the blood.		hp.json	Chronic partially decreased IgG4 in blood	http://purl.obolibrary.org/obo/HP_0041060		
GO:0044307	biolink:CellularComponent	dendritic branch	A dendrite arising from another dendrite.	NIF_Subcellular:sao884265541	hp.json	dendrite branch|secondary dendrite	http://purl.obolibrary.org/obo/GO_0044307		
HP:0041061	biolink:PhenotypicFeature	Fractured calcaneus	A partial or complete breakage of the calcaneus.		hp.json	bone calcaneus	http://purl.obolibrary.org/obo/HP_0041061		
UBERON:0004701	biolink:AnatomicalEntity	venous system endothelium	An endothelium that is part of a venous system [Automatically generated definition].	MA:0000714|NCIT:C49320|UMLS:C1710626|EMAPA:35907	hp.json		http://purl.obolibrary.org/obo/UBERON_0004701		
HP:0041064	biolink:PhenotypicFeature	Fractured knee	A partial or complete breakage of the knee.		hp.json	bone knee	http://purl.obolibrary.org/obo/HP_0041064		
UBERON:0004702	biolink:AnatomicalEntity	respiratory system blood vessel endothelium	A blood vessel endothelium that is part of a respiratory system [Automatically generated definition].	MA:0001805|EMAPA:35732	hp.json		http://purl.obolibrary.org/obo/UBERON_0004702		
HP:0041065	biolink:PhenotypicFeature	Chronic (near) absent circulating IgG2	A lasting absence of immunoglobulin G2 (IgG2) in the blood, whereby at most trace quantities of IgG2 can be measured.		hp.json	Chronic (near) absent IgG2 in blood	http://purl.obolibrary.org/obo/HP_0041065		
HP:0041062	biolink:PhenotypicFeature	Transient decreased circulating IgG2	A temporary reduction beneath the normal level of total immunoglobulin G2 (IgG2) in the blood circulation.		hp.json	Transient decreased IgG2 in blood	http://purl.obolibrary.org/obo/HP_0041062		
UBERON:0004700	biolink:AnatomicalEntity	arterial system endothelium	An endothelium that is part of an arterial system [Automatically generated definition].	MA:0000703|UMLS:C1706849|EMAPA:35145|NCIT:C49329	hp.json		http://purl.obolibrary.org/obo/UBERON_0004700		
HP:0041063	biolink:PhenotypicFeature	Chronic decreased cirulating IgG2	A lasting decrease of immunoglobulin G2 (IgG2) in the blood.		hp.json	Chronic decreased IgG2 in blood	http://purl.obolibrary.org/obo/HP_0041063		
HP:0041068	biolink:PhenotypicFeature	Chronic decreased circulating IgG1	A lasting decrease of immunoglobulin G1 (IgG1) in the blood.		hp.json	Chronic decreased IgG1 in blood	http://purl.obolibrary.org/obo/HP_0041068		
HP:0041069	biolink:PhenotypicFeature	Chronic (near) absent circulating IgG1	A lasting absence of immunoglobulin G1 (IgG1) in the blood, whereby at most trace quantities of IgG1 can be measured.		hp.json	Chronic (near) absent IgG1 in blood	http://purl.obolibrary.org/obo/HP_0041069		
HP:0041066	biolink:PhenotypicFeature	Chronic partially decreased circulating IgG2	A lasting limited decrease of immunoglobulin G2 (IgG2) in the blood.		hp.json	Chronic partially decreased IgG2 in blood	http://purl.obolibrary.org/obo/HP_0041066		
HP:0041067	biolink:PhenotypicFeature	Transient decreased circulating IgG1	A temporary reduction beneath the normal level of total immunoglobulin G1 (IgG1) in the blood circulation.		hp.json	Transient decreased IgG1 in blood	http://purl.obolibrary.org/obo/HP_0041067		
GO:0007369	biolink:BiologicalProcess	gastrulation	A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.	Wikipedia:Gastrulation	hp.json		http://purl.obolibrary.org/obo/GO_0007369		goslim_drosophila
HP:0041071	biolink:PhenotypicFeature	Transient decreased circulating IgG3	A temporary reduction beneath the normal level of total immunoglobulin G3 (IgG3) in the blood circulation.		hp.json	Transient decreased IgG3 in blood	http://purl.obolibrary.org/obo/HP_0041071		
HP:0041072	biolink:PhenotypicFeature	Chronic decreased circulating IgG3	A lasting decrease of immunoglobulin G3 (IgG3) in the blood.		hp.json	Chronic decreased IgG3 in blood	http://purl.obolibrary.org/obo/HP_0041072		
HP:0041070	biolink:PhenotypicFeature	Chronic partially decreased circulating IgG1	A lasting limited decrease of immunoglobulin G1 (IgG1) in the blood.		hp.json	Chronic partially decreased IgG1 in blood	http://purl.obolibrary.org/obo/HP_0041070		
HP:0041075	biolink:PhenotypicFeature	Chronic partially decreased circulating IgG3	A lasting limited decrease of immunoglobulin G3 (IgG3) in the blood.		hp.json	Chronic partially decreased IgG3 in blood	http://purl.obolibrary.org/obo/HP_0041075		
HP:0041076	biolink:PhenotypicFeature	Abnormal immunoglobulin level in body fluid	An abnormal deviation from normal levels of immunoglobulins in body fluids, such as mucous.		hp.json		http://purl.obolibrary.org/obo/HP_0041076		
HP:0041073	biolink:PhenotypicFeature	Fractured thoracic vertebra	A partial or complete breakage of the thoracic vertebra.		hp.json	bone thoracic vertebra	http://purl.obolibrary.org/obo/HP_0041073		
HP:0041074	biolink:PhenotypicFeature	Chronic (near) absent circulating IgG3	A lasting absence of immunoglobulin G3 (IgG3) in the blood, whereby at most trace quantities of IgG3 can be measured.		hp.json	Chronic (near) absent IgG3 in blood	http://purl.obolibrary.org/obo/HP_0041074		
HP:0041079	biolink:PhenotypicFeature	Decreased body fat percentage	The percentage of fat as a part of total body weight below the norm, usually defined as less than 14% for females and less than 8% for males.		hp.json	Decreased adipose tissue percentage	http://purl.obolibrary.org/obo/HP_0041079		
HP:0041077	biolink:PhenotypicFeature	Increased immunoglobulin level in body fluid	An elevation from normal levels of immunoglobulins in body fluids, such as mucous.		hp.json		http://purl.obolibrary.org/obo/HP_0041077		
HP:0041078	biolink:PhenotypicFeature	Decreased immunoglobulin level in body fluid	An reduction from normal levels of immunoglobulins in body fluids, such as mucous.		hp.json		http://purl.obolibrary.org/obo/HP_0041078		
GO:0007338	biolink:BiologicalProcess	single fertilization	The union of male and female gametes to form a zygote.		hp.json	zygote formation|zygote biosynthesis	http://purl.obolibrary.org/obo/GO_0007338		
GO:0009991	biolink:BiologicalProcess	response to extracellular stimulus	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.		hp.json		http://purl.obolibrary.org/obo/GO_0009991		
GO:0019319	biolink:BiologicalProcess	hexose biosynthetic process	The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.		hp.json	hexose anabolism|hexose synthesis|hexose formation|hexose biosynthesis	http://purl.obolibrary.org/obo/GO_0019319		
CHEBI:59561	biolink:ChemicalSubstance	diamino acid anion	An  organic anion that is the conjugate base of diamino acid.		hp.json	diamino acid anions	http://purl.obolibrary.org/obo/CHEBI_59561		3_STAR
GO:0009994	biolink:BiologicalProcess	oocyte differentiation	The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.		hp.json	oocyte cell differentiation	http://purl.obolibrary.org/obo/GO_0009994		
HP:0041082	biolink:PhenotypicFeature	Fractured skull	A partial or complete breakage of the skull.		hp.json		http://purl.obolibrary.org/obo/HP_0041082		
HP:0041083	biolink:PhenotypicFeature	Fractured phalanx	A partial or complete breakage of the phalanx.		hp.json	bone phalanx	http://purl.obolibrary.org/obo/HP_0041083		
GO:0019318	biolink:BiologicalProcess	hexose metabolic process	The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.		hp.json	hexose metabolism	http://purl.obolibrary.org/obo/GO_0019318		
HP:0041080	biolink:PhenotypicFeature	Abnormal proportion of exhausted T cells	A deviation from the normal proportion of exhausted T cell relative to T cell in the blood.		hp.json		http://purl.obolibrary.org/obo/HP_0041080		
GO:0071944	biolink:CellularComponent	cell periphery	The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.		hp.json		http://purl.obolibrary.org/obo/GO_0071944		goslim_flybase_ribbon
HP:0041081	biolink:PhenotypicFeature	Fractured lower leg	Bone fracture anywhere in the tibia, fibula, or ankle.		hp.json	Fracture of the lower leg|Lower limb fracture|Lower extremity fracture	http://purl.obolibrary.org/obo/HP_0041081		
HP:0004097	biolink:PhenotypicFeature	Deviation of finger	Deviated fingers is a term that should be used if one or more fingers of the hand are deviated from their normal position, either to the radial or ulnar side. A deviation of a finger can be caused by an abnormal form of one or more of the phalanges of the affected finger, or by a deviation or displacement of one or more phalanges.	SNOMEDCT_US:203556007|SNOMEDCT_US:26517000|UMLS:C0410740	hp.json	Finger pointing in a different direction than usual|Deviated fingers|Atypical position of finger	http://purl.obolibrary.org/obo/HP_0004097		
HP:0041086	biolink:PhenotypicFeature	Compression-fractured cervical vertebra	A fracture of the cervical vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.		hp.json	Wedge fractured cervical vertebra|Compression fractured cervical vertebra	http://purl.obolibrary.org/obo/HP_0041086		
HP:0041087	biolink:PhenotypicFeature	Compression-fractured lumbar vertebra	A fracture of the lumbar vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.		hp.json	Compression fractured lumbar vertebra|Wedge fractured lumbar vertebra	http://purl.obolibrary.org/obo/HP_0041087		
HP:0004095	biolink:PhenotypicFeature	Curved fingers		UMLS:C4025413	hp.json	Curved fingers	http://purl.obolibrary.org/obo/HP_0004095		
HP:0041084	biolink:PhenotypicFeature	Compression-fractured thoracic vertebra	A fracture of the thoracic vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.		hp.json	Compression fractured thoracic vertebra|Wedge fractured thoracic vertebra	http://purl.obolibrary.org/obo/HP_0041084		
HP:0041085	biolink:PhenotypicFeature	Compression-fractured vertebra	A fracture of the vertebra that is caused by a loss of bone mass (osteoporosis) that occurs as part of aging.		hp.json	Wedge fractured vertebra|Compression fractured vertebra	http://purl.obolibrary.org/obo/HP_0041085		
HP:0004099	biolink:PhenotypicFeature	Macrodactyly	Significant increase in the length and girth of most or all of a digit compared to its contralateral digit (if unaffected) or compared to what would be expected for age/body build. The increased girth is accompanied by an increase in the dorso-ventral dimension AND the lateral dimension of the digit.	MEDDRA:10025386|MSH:C562546|SNOMEDCT_US:48449000|UMLS:C0265552	hp.json	Finger overgrowth|Megalodactyly	http://purl.obolibrary.org/obo/HP_0004099		hposlim_core
HP:0041088	biolink:PhenotypicFeature	Avulsion fractured humerus	A fractured in which a fragment of the humerus tears away from the main mass of bone as a result of physical trauma.		hp.json		http://purl.obolibrary.org/obo/HP_0041088		
HP:0041089	biolink:PhenotypicFeature	Avulsion fractured tibia	A fractured in which a fragment of the tibia tears away from the main mass of bone as a result of physical trauma.		hp.json		http://purl.obolibrary.org/obo/HP_0041089		
GO:0007346	biolink:BiologicalProcess	regulation of mitotic cell cycle	Any process that modulates the rate or extent of progress through the mitotic cell cycle.		hp.json	mitotic cell cycle modulation|mitotic cell cycle regulation|modulation of mitotic cell cycle progression|regulation of progression through mitotic cell cycle|regulation of mitotic cell cycle progression|mitotic cell cycle regulator	http://purl.obolibrary.org/obo/GO_0007346		
GO:0007343	biolink:BiologicalProcess	egg activation	The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.	Wikipedia:Egg_activation	hp.json		http://purl.obolibrary.org/obo/GO_0007343		
HP:0041090	biolink:PhenotypicFeature	obsolete Avulsion fractured pelvic region of trunk			hp.json		http://purl.obolibrary.org/obo/HP_0041090		
HP:0041093	biolink:PhenotypicFeature	Beau's lines	A nail dystrophy that is preseents as grooved lines that run from side to side on the fingernail or the toenail that may look like indentations or ridges on the nail plate. They are caused by temporary disruption in the growth of proximal nail matrix. Trauma is usually the initiating factor such as infections, severe medical illnesses, major surgery/anesthesia, medication side effects, and autoimmune disease.		hp.json	Beau lines|Ladder nail|Ladder nail sign	http://purl.obolibrary.org/obo/HP_0041093		
HP:0041094	biolink:PhenotypicFeature	Complete tracheal ring	Continuous or nearly continuous configuration of the cartilaginous tracheal ring.		hp.json	Complete tracheal rings|CTRD|Complete tracheal ring deformity	http://purl.obolibrary.org/obo/HP_0041094		
HP:0041091	biolink:PhenotypicFeature	Avulsion fractured epiphysis of femur	A fractured in which the fragment of the epiphysis of femur bone tears away from the main mass of bone as a result of physical trauma.		hp.json		http://purl.obolibrary.org/obo/HP_0041091		
HP:0041092	biolink:PhenotypicFeature	Emotional hypersensitivity	Heightened emotional reactivity to environmental stimuli, including emotions of others.		hp.json	Highly sensitive|Hypersensitivity|Overly sensitive	http://purl.obolibrary.org/obo/HP_0041092		
HP:0041095	biolink:PhenotypicFeature	Decreased middle cerebral artery pulsatility index	Abnormally reduced blood flow pulsatility in in the middle cerebral artery (MCA). The pulsatility index (PI) is calculated using the following equation PI = (peak systolic velocity-end-diastolic velocity)/mean velocity.		hp.json		http://purl.obolibrary.org/obo/HP_0041095		
CHEBI:59558	biolink:ChemicalSubstance	medium-chain fatty acid anion	A fatty acid anion resulting from the deprotonation of the carboxylic acid moiety of a medium-chain fatty acid.		hp.json	medium-chain fatty acid anions|medium-chain FA anion|MCFA anion|a medium chain fatty acid|MCFA anions|medium-chain FA anions	http://purl.obolibrary.org/obo/CHEBI_59558		3_STAR
CHEBI:59554	biolink:ChemicalSubstance	medium-chain fatty acid	Any fatty acid with a chain length of between C6 and C12.		hp.json	MCFA|medium-chain fatty acids|MCFAs	http://purl.obolibrary.org/obo/CHEBI_59554		3_STAR
UBERON:0004739	biolink:AnatomicalEntity	pronephric glomerulus	The glomus forms from the splanchnic intermediate mesoderm and is the vascularized filtration unit, filtering the blood before it enters the tubules. The glomus is external to the nephron and extends over more than one body segment.	ZFA:0001557|TAO:0001557|AAO:0011049|XAO:0000318|VHOG:0001237	hp.json	glomus|pronephric glomeruli|glomera|corpuscle|pronephric glomus|pronephric glomera|glomerulus of pronephros	http://purl.obolibrary.org/obo/UBERON_0004739		
UBERON:0004736	biolink:AnatomicalEntity	metanephric glomerulus	Glomerulus of the mature vertebrate kidney, or metanephros.	VHOG:0001242	hp.json	glomerulus of metanephros	http://purl.obolibrary.org/obo/UBERON_0004736		
UBERON:0004737	biolink:AnatomicalEntity	metanephric collecting duct	A collecting duct of renal tubule that is part of a metanephros [Automatically generated definition].	VHOG:0000983	hp.json	collecting duct of metanephros|metanephric collecting tubule	http://purl.obolibrary.org/obo/UBERON_0004737		
GO:0044346	biolink:BiologicalProcess	fibroblast apoptotic process	Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.		hp.json	fibroblast apoptosis	http://purl.obolibrary.org/obo/GO_0044346		
GO:0010966	biolink:BiologicalProcess	regulation of phosphate transport	Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0010966		
GO:0010968	biolink:BiologicalProcess	regulation of microtubule nucleation	Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.		hp.json		http://purl.obolibrary.org/obo/GO_0010968		
GO:0010962	biolink:NamedThing	regulation of glucan biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0010962		
GO:0010960	biolink:BiologicalProcess	magnesium ion homeostasis	Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0010960		
PR:P09923	biolink:Protein	intestinal-type alkaline phosphatase (human)	An intestinal alkaline phosphatase that is encoded in the genome of human.	UniProtKB:P09923	hp.json	hALPI|IAP (human)|intestinal alkaline phosphatase (human)|ALPI	http://purl.obolibrary.org/obo/PR_P09923		
CHEBI:35571	biolink:ChemicalSubstance	mancude organic heterocyclic parent			hp.json	mancude organic heterocyclic parents|mancude-ring organic heterocyclic parents	http://purl.obolibrary.org/obo/CHEBI_35571		3_STAR
UBERON:0004742	biolink:AnatomicalEntity	dentary	The dentary is a dermal bone that forms the antero-lateral part of the lower jaw in fishes and amphibians, extending to the whole lower jaw in mammals[VHOG,modified].	VHOG:0001022|EFO:0003508|http://palaeos.com/vertebrates/bones/dermal/images/Dentary1.gif|AAO:0000124|ZFA:0000191|TAO:0000191	hp.json	dentaries|dentary bone|os dentale|dentale|sur-angulaire	http://purl.obolibrary.org/obo/UBERON_0004742		efo_slim
CHEBI:35570	biolink:ChemicalSubstance	mancude organic heterobicyclic parent			hp.json	mancude organic heterobicyclic parents|mancude-ring organic heterobicyclic parents	http://purl.obolibrary.org/obo/CHEBI_35570		3_STAR
CHEBI:35573	biolink:ChemicalSubstance	organic mancude parent			hp.json	organic mancude parents|organic mancude-ring parents	http://purl.obolibrary.org/obo/CHEBI_35573		3_STAR
UBERON:0004727	biolink:AnatomicalEntity	cochlear nerve	A nerve in the head that carries signals from the cochlea of the inner ear to the brain. It is part of the vestibulocochlear nerve, the 8th cranial nerve which is found in higher vertebrates; the other portion of the 8th cranial nerve is the vestibular nerve which carries spatial orientation information from the semicircular canals. The cochlear nerve is a sensory nerve, one which conducts to the brain information about the environment, in this case acoustic energy impinging on the tympanic membrane. The cochlear nerve arises from within the cochlea and extends to the brainstem, where its fibers make contact with the cochlear nucleus, the next stage of neural processing in the auditory system[WP].	MESH:D003056|FMA:53431|EMAPA:17802|GAID:723|EHDAA2:0002195|OpenCyc:Mx4rwIhQfZwpEbGdrcN5Y29ycA|MBA:948|BAMS:cVIIIn|BM:VIIIN|BTO:0003490|VHOG:0001182|NCIT:C12697|MA:0001110|UMLS:C0009201	hp.json	auditory nerve|nervus vestibulocochlearis|vestibulocochlear VIII nerve cochlear component|vestibulocochlear nerve cochlear component|cochlear component|cochlear root of acoustic nerve|cochlear root of eighth cranial nerve	http://purl.obolibrary.org/obo/UBERON_0004727		uberon_slim|pheno_slim
GO:0010976	biolink:BiologicalProcess	positive regulation of neuron projection development	Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).		hp.json	positive regulation of neurite biosynthesis|positive regulation of neurite formation|positive regulation of neurite growth|positive regulation of neurite development	http://purl.obolibrary.org/obo/GO_0010976		
GO:0010977	biolink:BiologicalProcess	negative regulation of neuron projection development	Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).		hp.json	negative regulation of neurite biosynthesis|negative regulation of neurite development|negative regulation of neurite growth|growth cone collapse|negative regulation of neurite formation	http://purl.obolibrary.org/obo/GO_0010977		
GO:0010975	biolink:BiologicalProcess	regulation of neuron projection development	Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).		hp.json	regulation of neurite growth|regulation of neurite formation|regulation of neurite development|regulation of neurite biosynthesis	http://purl.obolibrary.org/obo/GO_0010975		
GO:0007320	biolink:BiologicalProcess	insemination	The introduction of semen or sperm into the genital tract of a female.	Wikipedia:Insemination	hp.json		http://purl.obolibrary.org/obo/GO_0007320		
CHEBI:35586	biolink:ChemicalSubstance	1H-purine	The 1H-tautomer of purine.	Gmelin:2379911	hp.json	1H-purine	http://purl.obolibrary.org/obo/CHEBI_35586		3_STAR
CHEBI:11596	biolink:ChemicalSubstance	2-hydroxyglutarate(2-)	A dicarboxylic acid dianion resulting from the removal of a proton from both of the carboxylic acid groups of 2-hydroxyglutaric acid.	Reaxys:5736650|Beilstein:5736650|MetaCyc:2-HYDROXYGLUTARIC_ACID	hp.json	2-hydroxypentanedioate|2-hydroxyglutarate	http://purl.obolibrary.org/obo/CHEBI_11596		3_STAR
CHEBI:35588	biolink:ChemicalSubstance	3H-purine	The 3H-tautomer of purine.	Reaxys:1210196|PMID:6149478|PMID:7178185|PMID:7296170	hp.json	3H-purine	http://purl.obolibrary.org/obo/CHEBI_35588		3_STAR
CHEBI:35589	biolink:ChemicalSubstance	9H-purine	The 9H-tautomer of purine.	CAS:120-73-0|Wikipedia:Purine|Gmelin:3120|Beilstein:606899	hp.json	9H-purine|9H-purine	http://purl.obolibrary.org/obo/CHEBI_35589		3_STAR
GO:0010970	biolink:BiologicalProcess	transport along microtubule	The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.		hp.json	microtubule-based transport|establishment of localization by movement along microtubule|movement along microtubule	http://purl.obolibrary.org/obo/GO_0010970		
UBERON:0004734	biolink:AnatomicalEntity	gastrula	Organism at the gastrula stage.	FBbt:00005317|UMLS:C0017199|FMA:293108|BILA:0000060|UMLS:C1284022|GAID:1302|BTO:0001403|NCIT:C34058|NCIT:C34057|Wikipedia:Trilaminar_blastocyst|MESH:D005775|Wikipedia:Gastrula|MIAA:0000179	hp.json	blastocystis trilaminaris|trilaminar blastoderm|gastrula embryo|trilaminar disc|tri-laminar disk|trilaminar blastoderm|trilaminar blastocyst|trilaminar disk|tri-laminar disc|trilaminar blastocyst|trilaminar germ|blastocystis trilaminaris|trilaminar disk|tri-laminar disc|trilaminar disc|trilaminar germ|tri-laminar disk	http://purl.obolibrary.org/obo/UBERON_0004734		pheno_slim
GO:0009987	biolink:BiologicalProcess	cellular process	Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.		hp.json	single-organism cellular process|cell physiology|cellular physiological process|cell growth and/or maintenance	http://purl.obolibrary.org/obo/GO_0009987		gocheck_do_not_annotate|goslim_plant
GO:0071953	biolink:CellularComponent	elastic fiber	An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain.		hp.json	elastic fibre|elastin fiber	http://purl.obolibrary.org/obo/GO_0071953		
UBERON:0004732	biolink:AnatomicalEntity	segmental subdivision of nervous system	Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres.		hp.json	neuromere	http://purl.obolibrary.org/obo/UBERON_0004732		non_informative
UBERON:0004733	biolink:AnatomicalEntity	segmental subdivision of hindbrain	An organ subunit that is part of a hindbrain [Automatically generated definition].	FMA:61998	hp.json	segment of hindbrain|hindbrain segment	http://purl.obolibrary.org/obo/UBERON_0004733		non_informative
UBERON:0004731	biolink:AnatomicalEntity	neuromere	A transverse unitary subdivision of the neural tube that shares a common dorsoventral structure (floor, basal, alar, and roof plates), but each having differential molecular identities and fates; they comprise the secondary prosencephalon, diencephalon (prosomeres), the midbrain (mesomeres), and the hindbrain (rhombomeres).	TAO:0001328|ZFA:0001328|Wikipedia:Neuromere|NLX:147842	hp.json	neural segment|neuromeres|neural tube metameric segment|neural tube metameric segment|neural metamere|neural tube segment|neuromere	http://purl.obolibrary.org/obo/UBERON_0004731		pheno_slim
CHEBI:35584	biolink:ChemicalSubstance	purine	A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines.	PMID:12865945|KEGG:C15587|HMDB:HMDB0001366|PMID:24088627|MetaCyc:PURINE	hp.json	purine	http://purl.obolibrary.org/obo/CHEBI_35584		3_STAR
HP:0041048	biolink:PhenotypicFeature	Decreased expression of GPI-anchored proteins on the cell surface	A decrease in the protein expression fo GPI-anchor proteins, such as CD55 and CD59, at the cell surface, which suggests a defect in GPI-anchor biosynthesis.		hp.json		http://purl.obolibrary.org/obo/HP_0041048		
HP:0041049	biolink:PhenotypicFeature	Starch intolerance	An inability to digest starch.		hp.json	Amylose-amylopectin intolerance|Starch intolerance	http://purl.obolibrary.org/obo/HP_0041049		
UBERON:0004716	biolink:AnatomicalEntity	conceptus	The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP].	UMLS:C1516779|NCIT:C34131|Wikipedia:Conceptus|AEO:0000194|BTO:0003834|EMAPA:36040|EHDAA2:0000001|EHDAA2:0003235	hp.json	embryo plus adnexa	http://purl.obolibrary.org/obo/UBERON_0004716		
UBERON:0004714	biolink:AnatomicalEntity	septum pellucidum	A triangular double membrane, consisting of glial cells and fibers (Heimer, 1996) separating the anterior horns of the lateral ventricles of the brain. It is situated in the median plane and bounded by the corpus callosum and the body and columns of the fornix.	BIRNLEX:1315|MA:0002979|BAMS:spt|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=256|NCIT:C33536|BAMS:SptP|FMA:61844|MESH:D012688|UMLS:C0036700|UMLS:C0036700|BTO:0003448|DHBA:12098	hp.json	septum pellucidum of telencephalic ventricle|septal pellucidum|septum lucidum|septum gliosum|pellucidum|supracommissural septum|lateral septum	http://purl.obolibrary.org/obo/UBERON_0004714		pheno_slim
UBERON:0004715	biolink:AnatomicalEntity	annulus fibrosus disci intervertebralis	The ring of fibrocartilage and fibrous tissue forming the circumference of the intervertebral disc; surrounds the nucleus pulposus, which is prone to herniation when the annulus fibrosus is compromised.	EMAPA:32670|FMA:13551|BTO:0003629|MA:0000111	hp.json	anulus fibrosus (diskus intervertebralis)|fibrous ring of intervertebral disc|anulus fibrosus of intervertebral disk|annulus fibrosus|annulus fibrosus of intervertebral disc	http://purl.obolibrary.org/obo/UBERON_0004715		
GO:0010941	biolink:BiologicalProcess	regulation of cell death	Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.		hp.json		http://purl.obolibrary.org/obo/GO_0010941		
GO:0010942	biolink:BiologicalProcess	positive regulation of cell death	Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.		hp.json		http://purl.obolibrary.org/obo/GO_0010942		
GO:0010948	biolink:BiologicalProcess	negative regulation of cell cycle process	Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.		hp.json		http://purl.obolibrary.org/obo/GO_0010948		
CHEBI:35552	biolink:ChemicalSubstance	heterocyclic organic fundamental parent			hp.json	heterocyclic parent hydrides|heterocyclic fundamental parent|heterocyclic organic fundamental parents|organic heterocyclic fundamental parents	http://purl.obolibrary.org/obo/CHEBI_35552		3_STAR
CHEBI:35554	biolink:ChemicalSubstance	cardiovascular drug	A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.		hp.json	cardiovascular agent|cardiovascular drugs	http://purl.obolibrary.org/obo/CHEBI_35554		3_STAR
GO:0009952	biolink:BiologicalProcess	anterior/posterior pattern specification	The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.		hp.json	anterior/posterior pattern formation	http://purl.obolibrary.org/obo/GO_0009952		
UBERON:0004723	biolink:AnatomicalEntity	interlobular artery	The branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli[MP]. The first set of renal bloodvessels, the interlobular arteries (or cortical radiate arteries, or cortical radial arteries), are given off at right angles from the side of the arcuate arteries looking toward the cortical substance, and pass directly outward between the medullary rays to reach the fibrous tunic, where they end in the capillary network of this part. These vessels do not anastomose with each other, but form what are called end-arteries. In their outward course they give off lateral branches; these are the afferent vessels for the renal corpuscles; they enter the capsule, and end in the glomerulus. From each tuft the corresponding efferent vessel arises, and, having made its egress from the capsule near to the point where the afferent vessel enters, breaks up into a number of branches, which form a dense plexus within Bowman's capsule.	UMLS:C1512856|EMAPA:28212|FMA:70498|MA:0002584|NCIT:C32826	hp.json	interlobular renal artery|arteriae corticales radiatae|kidney interlobular artery|arteriae interlobulares renis|renal interlobular artery|cortical radial arteries|interlobular	http://purl.obolibrary.org/obo/UBERON_0004723		pheno_slim|human_reference_atlas
HP:0041042	biolink:PhenotypicFeature	Absent neutrophil lactoferrin	The absence of lactoferrin in neutrophil granules, which could be caused by either an isolated failure of synthesis of this protein (or the production of an antigenically unrecognizable form of lactoferrin) or a complete deficiency of specific granule production.		hp.json		http://purl.obolibrary.org/obo/HP_0041042		
HP:0041043	biolink:PhenotypicFeature	Neutrophil nuclear clefts	An abnormality of the nucleus of neutrophils, which presents as either a type I nuclear cleft, where the nuclear cleft may show a transition into a round/oval shape. The second type nuclear cleft, which runs perpendicular to the nuclear surface, and this type of cleft might be related to nuclear lobe formation.		hp.json		http://purl.obolibrary.org/obo/HP_0041043		
UBERON:0004724	biolink:AnatomicalEntity	medial palpebral ligament	The medial palpebral ligament (tendo oculi), about 4 mm. in length and 2 mm. in breadth, is attached to the frontal process of the maxilla in front of the lacrimal groove. Crossing the lacrimal sac, it divides into two parts, upper and lower, each attached to the medial end of the corresponding tarsus. As the ligament crosses the lacrimal sac, a strong aponeurotic is given off from its posterior surface; this expands over the sac, and is attached to the posterior lacrimal crest.	NCIT:C52724|UMLS:C0229251|EMAPA:37608|MA:0001258	hp.json	l. palpebrale mediale	http://purl.obolibrary.org/obo/UBERON_0004724		
HP:0041046	biolink:PhenotypicFeature	Increased neutrophil ribosomes	An increased number of ribosomes detected in neutrophils.		hp.json		http://purl.obolibrary.org/obo/HP_0041046		
UBERON:0004720	biolink:AnatomicalEntity	cerebellar vermis	A subregion of the cerebellar cortex, consisting of the most medial zone of the cerebellar cortex, stradding the midline. May be continuous with the lateral cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissures in others (e.g., ventrally).	FMA:76928|CALOHA:TS-2059|BAMS:VERM|NCIT:C33866|BAMS:Ver|MA:0000202|BIRNLEX:1175|UMLS:C0228482|MBA:645|EV:0100298|UMLS:C0228482|HBA:4698|BIRNLEX:1106|DMBA:16814|DHBA:10658|EMAPA:35214|MESH:D065814	hp.json	vermal parts of the cerebellum|vermis of cerebellum [I-X]|vermal regions|vermis cerebelli [I-X]|vermis of cerebellum|vermis cerebelli|cerebellum vermis|vermis	http://purl.obolibrary.org/obo/UBERON_0004720		pheno_slim|human_reference_atlas
HP:0041047	biolink:PhenotypicFeature	Bladder outlet obstruction	A compression or resistance upon the bladder outflow channel at any location from the bladder neck to urethral meatus, which usually causes lower urinary tract symptoms (LUTS).		hp.json	Obstruction of bladder outlet	http://purl.obolibrary.org/obo/HP_0041047		
HP:0041044	biolink:PhenotypicFeature	Low neutrophil alkaline phosphatase	An abnormally reduced level of alkaline phosphatase in neutrophils, which could be due to absence of enzyme or the production of defective enzyme.		hp.json		http://purl.obolibrary.org/obo/HP_0041044		
HP:0041045	biolink:PhenotypicFeature	Increased neutrophil mitochondria	An increased number of mitochondria detected in neutrophils.		hp.json		http://purl.obolibrary.org/obo/HP_0041045		
UBERON:0004709	biolink:AnatomicalEntity	pelvic appendage	Paired appendage that consists of the posterior appendicular skeleton and associated soft and hard tissues, but excludes the pelvic girdle and its associated soft and hard tissues.	VSAO:0000126	hp.json	posterior paired appendage|pelvic appendage|posterior appendage|pelvic limb/fin|hindlimb/pelvic fin|posterior limb/fin|pelvic limb/fin|hindlimb/pelvic fin	http://purl.obolibrary.org/obo/UBERON_0004709		homology_grouping
UBERON:0004707	biolink:AnatomicalEntity	pharyngula stage	A stage that follows the blastula, gastrula and neurula stages. At the pharyngula stage, all vertebrate embryos show remarkable similarities.	DrerDO:0000052|ZFS:0000050|EFO:0001310|OGES:000006	hp.json	phylotypic stage|pharyngula	http://purl.obolibrary.org/obo/UBERON_0004707		efo_slim
HP:0041059	biolink:PhenotypicFeature	Chronic (near) absent circulating IgG4	A lasting absence of immunoglobulin G4 (IgG4) in the blood, whereby at most trace quantities of IgG4 can be measured.		hp.json	Chronic (near) absent IgG4 in blood	http://purl.obolibrary.org/obo/HP_0041059		
GO:0007308	biolink:BiologicalProcess	oocyte construction	The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.		hp.json	oocyte arrangement	http://purl.obolibrary.org/obo/GO_0007308		
UBERON:0004708	biolink:AnatomicalEntity	paired limb/fin	An appendage that is part of an appendage girdle complex.	VSAO:0000067	hp.json	jointed paired lateral appendage|pectoral or pelvic appendage|pelvic/pectoral appendage|limb/fin|limb or fin|jointed paired lateral appendage|girdle-associated appendage|paired appendage|pelvic/pectoral appendage|pectoral or pelvic appendage|limb/fin|limb or fin|girdle-associated appendage	http://purl.obolibrary.org/obo/UBERON_0004708		homology_grouping
UBERON:0004706	biolink:AnatomicalEntity	bulbus cordis	A transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches.	EHDAA2:0000197|EHDAA:438|UMLS:C1284055|EHDAA:768|EMAPA:16333|SCTID:361525002|Wikipedia:Bulbus_cordis|NCIT:C34114|FMA:70300	hp.json	primitive right ventricle endocardium	http://purl.obolibrary.org/obo/UBERON_0004706		pheno_slim|vertebrate_core
UBERON:0004703	biolink:AnatomicalEntity	dorsal thalamus		EHDAA2:0000692|DHBA:10391|MA:0000180|BAMS:DOR|PBA:128013018|BM:Die-Th|ZFA:0000653|ncithesaurus:Dorsal_Thalamus|HBA:4393|EMAPA:35295|BAMS:Dorsal_thalamus|TAO:0000653|FMA:62007|DMBA:16396	hp.json	dorsal thalamus|thalamus proper|thalamus, pars dorsalis|dorsal tier of thalamus|dorsal thalamus (Anthoney)|thalamus dorsalis	http://purl.obolibrary.org/obo/UBERON_0004703		pheno_slim|vertebrate_core
UBERON:0004704	biolink:AnatomicalEntity	bone fossa	A depression or hollow in a bone[WP].	UMLS:C0836913|AAO:0010439|VSAO:0005069|FMA:45791|TAO:0001743|ZFA:0005388	hp.json	concavity|depression|depressions|fossae|concavities|fossa|groove	http://purl.obolibrary.org/obo/UBERON_0004704		vertebrate_core
GO:0010959	biolink:BiologicalProcess	regulation of metal ion transport	Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0010959		
CHEBI:35568	biolink:ChemicalSubstance	mancude ring	Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds.		hp.json	mancude-ring systems|mancude rings|mancunide-ring systems	http://purl.obolibrary.org/obo/CHEBI_35568		3_STAR
HP:0041050	biolink:PhenotypicFeature	Renal tubular cyst	Tubular lumnal dilatation/prominence lined by simple layer of cuboidal-to-flat tublar epihelial cells.		hp.json	Renal tubule cyst	http://purl.obolibrary.org/obo/HP_0041050		
HP:0041053	biolink:PhenotypicFeature	obsolete Fractured head			hp.json		http://purl.obolibrary.org/obo/HP_0041053		
UBERON:0004713	biolink:AnatomicalEntity	corpus cavernosum penis	One of the columns of erectile tissue forming the dorsum and sides of the penis.	FMA:19618|NCIT:C32382|EMAPA:29856|MA:0001743|UMLS:C1709494|EMAPA:29850|UMLS:C0227937|BTO:0002019|NCIT:C49269	hp.json	penis erectile tissue|corpus cavernosum penis|cavernous body of penis|corpus cavernosum|corpus spongiosum penis|corpus cavernosum of penis|penile corpus cavernosum|spongy body of penis|spongy body of male urethra	http://purl.obolibrary.org/obo/UBERON_0004713		
GO:0009966	biolink:BiologicalProcess	regulation of signal transduction	Any process that modulates the frequency, rate or extent of signal transduction.		hp.json	regulation of signaling pathway|regulation of signalling pathway	http://purl.obolibrary.org/obo/GO_0009966		
HP:0041054	biolink:PhenotypicFeature	obsolete Fractured thoracic segment of trunk			hp.json		http://purl.obolibrary.org/obo/HP_0041054		
GO:0009967	biolink:BiologicalProcess	positive regulation of signal transduction	Any process that activates or increases the frequency, rate or extent of signal transduction.		hp.json	up-regulation of signal transduction|up regulation of signal transduction|activation of signal transduction|positive regulation of signalling pathway|stimulation of signal transduction|upregulation of signal transduction|positive regulation of signaling pathway	http://purl.obolibrary.org/obo/GO_0009967		
UBERON:0004710	biolink:AnatomicalEntity	pectoral appendage	Paired appendage that consists of the anterior appendicular skeleton and associated soft and hard tissues, but excludes the pectoral girdle and its associated soft and hard tissues.	VHOG:0001753|VSAO:0000125	hp.json	pectoral limb/fin|forelimb or pectoral fin|anterior appendage|anterior paired appendage|forelimb - pectoral fin|anterior limb/fin|forelimb/pectoral fin	http://purl.obolibrary.org/obo/UBERON_0004710		homology_grouping
HP:0041051	biolink:PhenotypicFeature	Ageusia	A rare condition that is characterized by a complete loss of taste function of the tongue.		hp.json	Absent sense of taste|Impaired taste sensation|Lost taste	http://purl.obolibrary.org/obo/HP_0041051		
UBERON:0004711	biolink:AnatomicalEntity	jugular vein	The jugular veins are veins that bring deoxygenated blood from the head back to the heart via the superior vena cava.	EMAPA:18638|GAID:536|Wikipedia:Jugular_vein|NCIT:C12738|CALOHA:TS-0497|SCTID:244403000|UMLS:C0022427|BTO:0001744|MA:0002154|MESH:D007601	hp.json	vena jugularis|jugular	http://purl.obolibrary.org/obo/UBERON_0004711		
GO:0009968	biolink:BiologicalProcess	negative regulation of signal transduction	Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.		hp.json	inhibition of signal transduction|negative regulation of signaling pathway|downregulation of signal transduction|negative regulation of signalling pathway|down-regulation of signal transduction|down regulation of signal transduction	http://purl.obolibrary.org/obo/GO_0009968		
HP:0041052	biolink:PhenotypicFeature	Agenesis of putamen	A developmental defect characterized by the absence of the putamen owing to its failure to develop.		hp.json		http://purl.obolibrary.org/obo/HP_0041052		
HP:0041057	biolink:PhenotypicFeature	Transient decreased circulating IgG4	A temporary reduction beneath the normal level of total immunoglobulin G4 (IgG4) in the blood circulation.		hp.json	Transient decreased IgG4 in blood	http://purl.obolibrary.org/obo/HP_0041057		
GO:0071971	biolink:BiologicalProcess	extracellular exosome assembly	The aggregation, arrangement and bonding together of a set of components to form an extracellular vesicular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Exosomes are defined by their size, which generally ranges from 30 nm to 100 nm.		hp.json	extracellular vesicular exosome assembly	http://purl.obolibrary.org/obo/GO_0071971		
HP:0041058	biolink:PhenotypicFeature	Chronic decreased circulating IgG4	A lasting decrease of immunoglobulin G4 (IgG4) in the blood.		hp.json	Chronic decreased IgG4 in blood	http://purl.obolibrary.org/obo/HP_0041058		
HP:0041055	biolink:PhenotypicFeature	Fractured humerus	A partial or complete breakage of the humerus.		hp.json	Humeral fracture|Humerus fracture|Fracture of the humerus|Broken humerus|bone humerus	http://purl.obolibrary.org/obo/HP_0041055		
HP:0041056	biolink:PhenotypicFeature	Hot cross bun sign	A cruciform-shaped hyperintensity within the pons found on T2-weighted magnetic resonance imaging (MRI).		hp.json		http://purl.obolibrary.org/obo/HP_0041056		
HP:0031661	biolink:PhenotypicFeature	Abnormal second heart sound	Any anomaly of the second heart sound (S2), which is produced by aortic (A2) and pulmonic (P2) valve closure. The A2-P2 interval normally increases with inspiration and narrows with expiration.		hp.json		http://purl.obolibrary.org/obo/HP_0031661		
HP:0031662	biolink:PhenotypicFeature	Fixed splitting of the second heart sound	Lack of variation in the splitting between the two components of the second heart sound with respiration. Normally, the aortic valve closure (A2) is followed by the pulmonic valve closure (P2) but the A2-P2 interval increases with inspiration and decreases with expiration.		hp.json	Fixed splitting of S2	http://purl.obolibrary.org/obo/HP_0031662		
HP:0031663	biolink:PhenotypicFeature	Paradoxical splitting of the second heart sound	Normally, the aortic valve closure (A2) is followed by the pulmonic valve closure (P2) but the A2-P2 interval increases with inspiration and decreases with expiration. With paradoxical splitting, there is a delay in the closure of the aortic valve, so that A2 can follow P2; the individual components can be appreciated at the end of expiration and the interval narrows with inspiration (which is the oposite of the normal pattern).		hp.json	Paradoxical splitting of S2|Reversed splitting of S2|Reversed splitting of the second heart sound	http://purl.obolibrary.org/obo/HP_0031663		
HP:0031664	biolink:PhenotypicFeature	Systolic heart murmur	A heart murmur limited to systole, i.e., between the first and second heart sounds S1 and S2.		hp.json		http://purl.obolibrary.org/obo/HP_0031664		
HP:0031660	biolink:PhenotypicFeature	Loud first heart sound	Abnormally increased volume of the first heart sound.		hp.json		http://purl.obolibrary.org/obo/HP_0031660		
NBO:0002519	biolink:NamedThing	adipsia	"A pathological drinking behavior characterised by a lack of desire to drink." [NBO:GVG]		hp.json		http://purl.obolibrary.org/obo/NBO_0002519		
HP:0004039	biolink:PhenotypicFeature	Abnormal ulnar metaphysis morphology	Any structural abnormality of the portion of the ulna between the epiphysis and the diaphysis.	UMLS:C4025424	hp.json	Abnormality of ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0004039		
HP:0031669	biolink:PhenotypicFeature	Middiastolic murmur	A murmur that occurs in the middle of the diastolic phase.		hp.json		http://purl.obolibrary.org/obo/HP_0031669		
HP:0004038	biolink:PhenotypicFeature	obsolete Bony spicule of ulnar epiphyseal plate			hp.json		http://purl.obolibrary.org/obo/HP_0004038		
HP:0004037	biolink:PhenotypicFeature	Abnormal ulnar epiphysis morphology		UMLS:C4021689	hp.json	Abnormality of the ulnar epiphyses|Abnormality of the epiphyseal plate of the ulna	http://purl.obolibrary.org/obo/HP_0004037		
HP:0004036	biolink:PhenotypicFeature	Long styloid process of ulna		UMLS:C4025426	hp.json		http://purl.obolibrary.org/obo/HP_0004036		
HP:0006698	biolink:PhenotypicFeature	Dilatation of the ventricular cavity	A localized outpouching of ventricular cavity that is generally associated with dyskinesia and paradoxical expansion during systole.	UMLS:C0392464|SNOMEDCT_US:90539001	hp.json	Ventricular aneurysm	http://purl.obolibrary.org/obo/HP_0006698		
HP:0031665	biolink:PhenotypicFeature	Midsystolic murmur	A systolic murmur that begins after S1 and ends before S2, typically with a crescendo-decrescendo pattern.		hp.json		http://purl.obolibrary.org/obo/HP_0031665		
HP:0006699	biolink:PhenotypicFeature	Premature atrial contractions	A type of cardiac arrhythmia with premature atrial contractions or beats caused by signals originating from ectopic atrial sites.	UMLS:C0033036|SNOMEDCT_US:63593006|SNOMEDCT_US:406461004|MSH:D018880|SNOMEDCT_US:287057009|SNOMEDCT_US:284470004	hp.json	Atrial premature complex|Ectopic supraventricular rhythms|PACs|Premature supraventricular beats|Atrial ectopic beats	http://purl.obolibrary.org/obo/HP_0006699		
HP:0031666	biolink:PhenotypicFeature	Late systolic murmur	A murmur that occurs in the latter phase of systole.		hp.json		http://purl.obolibrary.org/obo/HP_0031666		
HP:0031667	biolink:PhenotypicFeature	Holosystolic murmur	A heart murmur that occurs during the entire systolic phase from S1 to S2.		hp.json		http://purl.obolibrary.org/obo/HP_0031667		
HP:0031668	biolink:PhenotypicFeature	Diastolic heart murmur	A heart murmur that occurs during diastole, i.e., in the time between S2 and the subsequent S1.		hp.json		http://purl.obolibrary.org/obo/HP_0031668		
HP:0006694	biolink:PhenotypicFeature	Early progressive calcific cardiac valvular disease		UMLS:C4024999	hp.json		http://purl.obolibrary.org/obo/HP_0006694		
HP:0004031	biolink:PhenotypicFeature	Broad radial diaphysis	Increase in width of the diaphysis of radius.	UMLS:C4021690	hp.json	Wide radial diaphysis	http://purl.obolibrary.org/obo/HP_0004031		
HP:0006695	biolink:PhenotypicFeature	Atrioventricular canal defect	A defect of the atrioventricular septum of the heart.	UMLS:C0014116|UMLS:C1389016|MSH:D004694|Fyler:606|SNOMEDCT_US:15459006|Fyler:1100|Fyler:0606|MSH:C562831	hp.json	Hole in center of heart|Hole in centre of heart|Atrioventricular septal defect|Endocardial cushion defect	http://purl.obolibrary.org/obo/HP_0006695		
HP:0004030	biolink:PhenotypicFeature	Patchy sclerosis of radial diaphysis		UMLS:C4025431	hp.json		http://purl.obolibrary.org/obo/HP_0004030		
HP:0006696	biolink:PhenotypicFeature	Polymorphic and polytopic ventricular extrasystoles		UMLS:C4024998	hp.json		http://purl.obolibrary.org/obo/HP_0006696		
HP:0006690	biolink:PhenotypicFeature	Myocardial calcification	Calcium deposition in the myocardium.	UMLS:C1096561|Fyler:1889	hp.json	Calcified myocardium	http://purl.obolibrary.org/obo/HP_0006690		
HP:0004035	biolink:PhenotypicFeature	Abnormal ulnar styloid process morphology		UMLS:C4025427	hp.json	Abnormality of the styloid process of ulna	http://purl.obolibrary.org/obo/HP_0004035		
HP:0006691	biolink:PhenotypicFeature	Pulmonic valve myxoma		UMLS:C4025002	hp.json		http://purl.obolibrary.org/obo/HP_0006691		
HP:0004034	biolink:PhenotypicFeature	Irregular olecranon		UMLS:C4025428	hp.json		http://purl.obolibrary.org/obo/HP_0004034		
HP:0006692	biolink:PhenotypicFeature	Short chordae tendineae of the tricuspid valve	Abnormally short chordae tendineae of the tricuspid valve.	UMLS:C4025001	hp.json		http://purl.obolibrary.org/obo/HP_0006692		
HP:0004033	biolink:PhenotypicFeature	Curved olecranon		UMLS:C4025429	hp.json		http://purl.obolibrary.org/obo/HP_0004033		
HP:0004032	biolink:PhenotypicFeature	Abnormal olecranon morphology	Any structural abnormality of the olecranon, a bony eminence of the proximal ulna.	UMLS:C4025430	hp.json	Abnormality of the olecranon	http://purl.obolibrary.org/obo/HP_0004032		
HP:0006693	biolink:PhenotypicFeature	Myocardial steatosis	Steatosis in the myocardium.	UMLS:C4025000	hp.json		http://purl.obolibrary.org/obo/HP_0006693		
HP:0031672	biolink:PhenotypicFeature	Reverse typical atrial flutter	A type of atrial flutter associated with rounded or bimodal positive deflections in inferior leads II, III and aVF, and a very characteristic bimodal negative wave in the shape of a W is seen in lead V1.		hp.json		http://purl.obolibrary.org/obo/HP_0031672		
HP:0031673	biolink:PhenotypicFeature	Orthodromic atrioventricular reentrant tachycardia	A type of atrioventricular reentrant tachycardia (AVRT) where the atrioventricular node is used for anterograde conduction and the accessory pathway for retrograde conduction.		hp.json	Orthodromic AVRT	http://purl.obolibrary.org/obo/HP_0031673		
HP:0031674	biolink:PhenotypicFeature	Antidromic atrioventricular reentrant tachycardia	A type of atrioventricular reentrant tachycardia (AVRT) where the accessory pathway is used for anterograde conduction and the atrioventricular node for retrograde conduction.		hp.json	Antidromic AVRT	http://purl.obolibrary.org/obo/HP_0031674		
HP:0031675	biolink:PhenotypicFeature	Fascicular left ventricular tachycardia	A ventricular tachycardia (VT) characterized by right bundle branch block (RBBB) and left axis deviation (LAD) on electrocardiogram (ECG).		hp.json		http://purl.obolibrary.org/obo/HP_0031675		
HP:0031670	biolink:PhenotypicFeature	Continuous heart murmur	A murmur that occurs in both systole and diastole.		hp.json		http://purl.obolibrary.org/obo/HP_0031670		
HP:0031671	biolink:PhenotypicFeature	Typical atrial flutter	Typical atrial flutter is an organised atrial tachycardia. It can also be defined as a macroreentrant tachycardia confined to the right atrium. This arrhythmia has a 200-260 ms cycle length, although it may fluctuate depending on patient's previous treatment or ablation, congenital heart disease, etc. Ventricular rate response will be limited by the atrioventricular node conductions, usually presenting a 2:1 or 3:1 response, during atrial flutter. Typical (counter clockwise) flutter is associated with the common flutter pattern: a regular continuous undulation with dominant negative deflections in inferior leads II, III and aVF, often described also as a saw tooth pattern, and flat atrial deflections in leads I and aVL. Atrial deflections in V1 can be positive, biphasic or negative.		hp.json		http://purl.obolibrary.org/obo/HP_0031671		
UBERON:5006052	biolink:AnatomicalEntity	digit 5 plus metapodial segment	A subdivision of the autopod consisting of digit 5 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	digit 5 ( phalanges plus metapodial) plus soft tissue|digit 5 digitopodial subdivision|digit 5 ray|digit V plus metapodial segment|digit 5	http://purl.obolibrary.org/obo/UBERON_5006052		
HP:0004049	biolink:PhenotypicFeature	Decreased carpal angles of wrist		UMLS:C4025416	hp.json		http://purl.obolibrary.org/obo/HP_0004049		
UBERON:5006050	biolink:AnatomicalEntity	digit 3 plus metapodial segment	A subdivision of the autopod consisting of digit 3 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	digit 3 digitopodial subdivision|digit 3 ( phalanges plus metapodial) plus soft tissue|digit III plus metapodial segment|digit 3 ray|digit 3	http://purl.obolibrary.org/obo/UBERON_5006050		
HP:0004048	biolink:PhenotypicFeature	Narrow joint spaces of wrist		UMLS:C4025417	hp.json		http://purl.obolibrary.org/obo/HP_0004048		
UBERON:5006051	biolink:AnatomicalEntity	digit 4 plus metapodial segment	A subdivision of the autopod consisting of digit 4 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	digit 4 ( phalanges plus metapodial) plus soft tissue|digit 4 digitopodial subdivision|digit 4 ray|digit 4|digit IV plus metapodial segment	http://purl.obolibrary.org/obo/UBERON_5006051		
HP:0004047	biolink:PhenotypicFeature	Wide ulnar metaphysis	Increase in width (breadth) of the ulnar metaphysis.	UMLS:C4021687	hp.json	Broad ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0004047		
HP:0031676	biolink:PhenotypicFeature	Monomorphic ventricular tachycardia	A type of ventricular tachycardia that is characterized by uniform QRS complexes within each lead (i.e., each QRS is identical or nearly so).		hp.json		http://purl.obolibrary.org/obo/HP_0031676		
HP:0031677	biolink:PhenotypicFeature	Polymorphic ventricular tachycardia	A type of ventricular tachycardia that is characterized by variable QRS complexes within each lead (i.e., QRS complexes may be different from beat to beat).		hp.json		http://purl.obolibrary.org/obo/HP_0031677		
HP:0031678	biolink:PhenotypicFeature	Atherosclerotic lesion	A lesion associated with atherosclerosis, a multifactorial and multipart progressive disease manifested by the focal development within the arterial wall of lesions, that ranges from teh development of a fatty streak, plaque progression, and plaque disruption. Atherosclerotic lesions demonstrate consistent morphological characteristics, which indicate that each type may stabilize temporarily or permanently and that progression to the next type may require an additional stimulus.		hp.json		http://purl.obolibrary.org/obo/HP_0031678		
HP:0031679	biolink:PhenotypicFeature	Type I atherosclerotic lesion	Type I lesions represent the very initial changes and are recognized as an increase in the number of intimal macrophages and the appearance of macrophages filled with lipid droplets (foam cells).		hp.json		http://purl.obolibrary.org/obo/HP_0031679		
HP:0004042	biolink:PhenotypicFeature	Ulnar metaphyseal irregularity	Irregularity of the normally smooth surface of the metaphysis of the ulna.	UMLS:C4021688	hp.json	Irregular ulnar metaphysis	http://purl.obolibrary.org/obo/HP_0004042		
HP:0004041	biolink:PhenotypicFeature	Cupped ulnar metaphysis		UMLS:C4025422	hp.json		http://purl.obolibrary.org/obo/HP_0004041		
GO:0032388	biolink:BiologicalProcess	positive regulation of intracellular transport	Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.		hp.json	up regulation of intracellular transport|activation of intracellular transport|stimulation of intracellular transport|upregulation of intracellular transport|up-regulation of intracellular transport	http://purl.obolibrary.org/obo/GO_0032388		
HP:0004040	biolink:PhenotypicFeature	Corner fragments of ulnar metaphysis		UMLS:C4025423	hp.json		http://purl.obolibrary.org/obo/HP_0004040		
GO:0032387	biolink:BiologicalProcess	negative regulation of intracellular transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.		hp.json	down-regulation of intracellular transport|down regulation of intracellular transport|downregulation of intracellular transport|inhibition of intracellular transport	http://purl.obolibrary.org/obo/GO_0032387		
GO:0032386	biolink:BiologicalProcess	regulation of intracellular transport	Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.		hp.json		http://purl.obolibrary.org/obo/GO_0032386		
HP:0004046	biolink:PhenotypicFeature	Spurred ulnar metaphysis		UMLS:C4025418	hp.json		http://purl.obolibrary.org/obo/HP_0004046		
HP:0004045	biolink:PhenotypicFeature	Sloping ulnar metaphysis	A sloped configuration of the metaphysis (shaft) of the ulna.	UMLS:C4025419	hp.json		http://purl.obolibrary.org/obo/HP_0004045		
HP:0004044	biolink:PhenotypicFeature	Pointed ulnar metaphysis		UMLS:C4025420	hp.json		http://purl.obolibrary.org/obo/HP_0004044		
HP:0004043	biolink:PhenotypicFeature	Lytic defects of ulnar metaphysis		UMLS:C4025421	hp.json		http://purl.obolibrary.org/obo/HP_0004043		
HP:0031683	biolink:PhenotypicFeature	Type VI atherosclerotic lesion	Type VI atherosclerotic lesions generally have the underlying morphology of type IV or V lesions, surface disruptions, hematoma, and thrombosis may be (although less often) superimposed on any other type of lesion and even on intima without an apparent lesion. Complicating features may arise because of individual differences in risk factors and tissue reactions. These may include differences in composition of the blood, the relative quantities and distributions in the components of the underlying lesion or intima, as well as modifications of shear and tensile forces to which the lesion or intima is exposed. Clinical imaging of lesions may be expected to contribute greatly to the understanding of type VI lesions and the associated clinical syndromes.		hp.json		http://purl.obolibrary.org/obo/HP_0031683		
HP:0031684	biolink:PhenotypicFeature	Renal artery atherosclerosis	An atherosclerotic lesion located in the renal artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031684		
HP:0031685	biolink:PhenotypicFeature	Abnormal stool composition	Abnormal level of metabolite or other abnormal analyte result in a stool test.		hp.json	Abnormal feces composition|Abnormal fecal test result|Abnormal faeces composition	http://purl.obolibrary.org/obo/HP_0031685		
HP:0031686	biolink:PhenotypicFeature	Increased stool alpha1-antitrypsin concentration	An abnormally elevated amount of alpha1-antitrypsin in the feces.		hp.json		http://purl.obolibrary.org/obo/HP_0031686		
HP:0031680	biolink:PhenotypicFeature	Type II atherosclerotic lesion	Type II atherosclerotic lesions include the fatty streak lesion, the first grossly visible lesion, and are characterized by layers of macrophage foam cells and lipid droplets within intimal smooth muscle cells and minimal coarse-grained particles and heterogeneous droplets of extracellular lipid.		hp.json		http://purl.obolibrary.org/obo/HP_0031680		
HP:0031681	biolink:PhenotypicFeature	Type III atherosclerotic lesion	Type III (intermediate) atherosclerotic lesions are the morphological and chemical bridge between type II and advanced lesions. Type III lesions appear in some adaptive intimal thickenings (progression-prone locations) in young adults and are characterized by pools of extracellular lipid in addition to all the components of type II lesions.		hp.json		http://purl.obolibrary.org/obo/HP_0031681		
HP:0031682	biolink:PhenotypicFeature	Type V atherosclerotic lesion	Type V lesions are defined as lesions in which prominent new fibrous connective tissue has formed. When the new tissue is part of a lesion with a lipid core (type IV), this type of morphology may be referred to as fibroatheroma or type Va lesion. A type V lesion in which the lipid core and other parts of the lesion are calcified may be referred to as type Vb. A type V lesion in which a lipid core is absent and lipid in general is minimal may be referred to as type Vc. With these lesions, arteries are variously narrowed, generally more than with type IV. Importantly, as with type IV lesions, type V lesions may develop fissures, hematoma, and/or thrombus (type VI lesion), and for this reason too they are clinically relevant.		hp.json		http://purl.obolibrary.org/obo/HP_0031682		
GO:0046907	biolink:BiologicalProcess	intracellular transport	The directed movement of substances within a cell.		hp.json	single organism intracellular transport|single-organism intracellular transport	http://purl.obolibrary.org/obo/GO_0046907		
HP:0004017	biolink:PhenotypicFeature	Exostoses of the radial metaphysis		UMLS:C4025442	hp.json		http://purl.obolibrary.org/obo/HP_0004017		
HP:0004016	biolink:PhenotypicFeature	Cupped radial metaphyses		UMLS:C4025443	hp.json		http://purl.obolibrary.org/obo/HP_0004016		
GO:0032370	biolink:BiologicalProcess	positive regulation of lipid transport	Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	up-regulation of lipid transport|up regulation of lipid transport|activation of lipid transport|stimulation of lipid transport|upregulation of lipid transport	http://purl.obolibrary.org/obo/GO_0032370		
HP:0004015	biolink:PhenotypicFeature	Abnormal radial metaphysis morphology		UMLS:C4025444	hp.json	Abnormality of radial metaphyses	http://purl.obolibrary.org/obo/HP_0004015		
HP:0004014	biolink:PhenotypicFeature	Broad radial epiphyseal plate	Abnormal increase in width of the epiphyseal growth plate of the radius.	UMLS:C4021693	hp.json	Wide radial epiphyseal plates	http://purl.obolibrary.org/obo/HP_0004014		
GO:0046903	biolink:BiologicalProcess	secretion	The controlled release of a substance by a cell or a tissue.		hp.json		http://purl.obolibrary.org/obo/GO_0046903		goslim_pir
HP:0031687	biolink:PhenotypicFeature	Abnormally loud pulmonic component of the second heart sound			hp.json	Accentuation of the pulmonic component of the second heart sound	http://purl.obolibrary.org/obo/HP_0031687		
HP:0006677	biolink:PhenotypicFeature	Prolonged QRS complex	Increased time for the complex comprised of the Q wave, R wave, and S wave as measured by the electrocardiogram (EKG).. In adults, normal values are 0.06 - 0.10 sec.	SNOMEDCT_US:991002|UMLS:C0235475	hp.json	Intraventricular conduction delay|Prolonged QRS complex on EKG|QRS widening	http://purl.obolibrary.org/obo/HP_0006677		
HP:0031688	biolink:PhenotypicFeature	Erythroid dysplasia	Dysplasia in the erythroid lineage, which presents with a variety of morphological changes in the bone marrow, including nuclear budding or irregular nuclear contour in erythroblasts.		hp.json		http://purl.obolibrary.org/obo/HP_0031688		
HP:0004019	biolink:PhenotypicFeature	Radial metaphyseal irregularity	Irregularity of the normally smooth surface of the metaphysis of the radius.	UMLS:C4021692	hp.json	Irregular radial metaphysis	http://purl.obolibrary.org/obo/HP_0004019		
HP:0031689	biolink:PhenotypicFeature	Megakaryocyte dysplasia	The presence of micro-megakaryocytes, hypo-lobed, or non-lobed nuclei in megakaryocytes of all sizes and multiple, widely-separated nuclei.		hp.json	Dysmegakaryopoiesis	http://purl.obolibrary.org/obo/HP_0031689		
CHEBI:60525	biolink:ChemicalSubstance	molybdenum cofactor(2-)	Molybdenum cofactor MoCo protonated to pH 7.3.	PMID:20356030|PDB:3HBG|PDB:3HBQ|PDBeChem:MSS|PDB:3HBP	hp.json	MoCo	http://purl.obolibrary.org/obo/CHEBI_60525		3_STAR
HP:0006679	biolink:PhenotypicFeature	Granulomatous coronary arteritis	Inflammation of the coronary arteries involving a granulomatous response, i.e., a non-specific inflammatory response involving granulomas, defined as a compact organized collection of mature mononuclear phagocytes including epithelioid and giant cells.	UMLS:C4025007	hp.json		http://purl.obolibrary.org/obo/HP_0006679		
HP:0004018	biolink:PhenotypicFeature	Flared radial metaphysis	The presence of a splayed (i.e.,flared) metaphyseal segment of the radius.	UMLS:C4025441	hp.json	Broadening of the distal radius	http://purl.obolibrary.org/obo/HP_0004018		
UBERON:5006049	biolink:AnatomicalEntity	digit 2 plus metapodial segment	A subdivision of the autopod consisting of digit 2 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	digit II plus metapodial segment|digit 2|digit 2 digitopodial subdivision|digit 2 ( phalanges plus metapodial) plus soft tissue|digit 2 ray	http://purl.obolibrary.org/obo/UBERON_5006049		
GO:0032379	biolink:BiologicalProcess	positive regulation of intracellular lipid transport	Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells.		hp.json	up-regulation of intracellular lipid transport|up regulation of intracellular lipid transport|activation of intracellular lipid transport|stimulation of intracellular lipid transport|upregulation of intracellular lipid transport	http://purl.obolibrary.org/obo/GO_0032379		
GO:0032378	biolink:BiologicalProcess	negative regulation of intracellular lipid transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells.		hp.json	inhibition of intracellular lipid transport|downregulation of intracellular lipid transport|down-regulation of intracellular lipid transport|down regulation of intracellular lipid transport	http://purl.obolibrary.org/obo/GO_0032378		
HP:0006673	biolink:PhenotypicFeature	Reduced systolic function		UMLS:C4025008	hp.json		http://purl.obolibrary.org/obo/HP_0006673		
GO:0032377	biolink:BiologicalProcess	regulation of intracellular lipid transport	Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.		hp.json		http://purl.obolibrary.org/obo/GO_0032377		
UBERON:5006048	biolink:AnatomicalEntity	digit 1 plus metapodial segment	A subdivision of the autopod consisting of digit 1 plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis.		hp.json	digit 1 ray|digit 1|digit 1 digitopodial subdivision|digit I plus metapodial segment|digit 1 ( phalanges plus metapodial) plus soft tissue	http://purl.obolibrary.org/obo/UBERON_5006048		
HP:0004013	biolink:PhenotypicFeature	Medially fused radial epiphyseal plates		UMLS:C4025445	hp.json		http://purl.obolibrary.org/obo/HP_0004013		
HP:0004012	biolink:PhenotypicFeature	Premature fusion of the radial epiphyseal plates	A premature fusion of the epiphyseal plates of the radius. Epiphyseal plates are located at the distal and proximal ends of the long bones, in this case of the radius and premature fusion will have an effect on the growh of the radial bone, inhibiting or at least disturbing the normal growth and development of the bone.	UMLS:C4025446	hp.json		http://purl.obolibrary.org/obo/HP_0004012		
HP:0006670	biolink:PhenotypicFeature	Impaired myocardial contractility		UMLS:C4025009	hp.json		http://purl.obolibrary.org/obo/HP_0006670		
HP:0004010	biolink:PhenotypicFeature	Small radial epiphyses		UMLS:C4025447	hp.json		http://purl.obolibrary.org/obo/HP_0004010		
HP:0006671	biolink:PhenotypicFeature	Paroxysmal atrial tachycardia		UMLS:C0030587|SNOMEDCT_US:195069001	hp.json		http://purl.obolibrary.org/obo/HP_0006671		
GO:0032369	biolink:BiologicalProcess	negative regulation of lipid transport	Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json	down-regulation of lipid transport|down regulation of lipid transport|inhibition of lipid transport|downregulation of lipid transport	http://purl.obolibrary.org/obo/GO_0032369		
HP:0031694	biolink:PhenotypicFeature	Severe adenovirus infection	An unusually severe adenovirus infection.		hp.json		http://purl.obolibrary.org/obo/HP_0031694		
HP:0031695	biolink:PhenotypicFeature	Severe parainfluenza infection	An unusually severe infection by a parainfluenza virus.		hp.json		http://purl.obolibrary.org/obo/HP_0031695		
HP:0031696	biolink:PhenotypicFeature	Disseminated viral infection	A viral infection that fails to be contained by the immune sytem and spreads throughout the body.		hp.json		http://purl.obolibrary.org/obo/HP_0031696		
HP:0031697	biolink:PhenotypicFeature	Disseminated infection with live vaccine virus	A dissemination viral infection caused by a live attenuated vaccine virus.		hp.json		http://purl.obolibrary.org/obo/HP_0031697		
HP:0031690	biolink:PhenotypicFeature	Opportunistic infection	An infection that is caused by a pathogen that would generally not be able to cause an infection in a host with a normal immune system. Such pathogens take advantage of the opportunity, so to speak, that is provided by a weakened immune system.		hp.json		http://purl.obolibrary.org/obo/HP_0031690		
HP:0031691	biolink:PhenotypicFeature	Severe viral infection	An unusually severe viral infection.		hp.json		http://purl.obolibrary.org/obo/HP_0031691		
HP:0031692	biolink:PhenotypicFeature	Severe cytomegalovirus infection	An unusually severe infection by cytomegalovirus.		hp.json		http://purl.obolibrary.org/obo/HP_0031692		
HP:0031693	biolink:PhenotypicFeature	Severe Epstein Barr virus infection	An unusually severe Epstein Barr virus (EBV) infection.		hp.json	Severe EBV infection|Fulminant infectious mononucleosis	http://purl.obolibrary.org/obo/HP_0031693		
HP:0004028	biolink:PhenotypicFeature	Spurs of radial diaphysis		UMLS:C4025433	hp.json		http://purl.obolibrary.org/obo/HP_0004028		
HP:0004027	biolink:PhenotypicFeature	Abnormality of radial diaphysis	An anomaly of the radial diaphysis.	UMLS:C4025434	hp.json		http://purl.obolibrary.org/obo/HP_0004027		
HP:0004026	biolink:PhenotypicFeature	Broad radial metaphysis	Increase in width (breadth) of the radial metaphysis.	UMLS:C4021691	hp.json	Wide radial metaphysis	http://purl.obolibrary.org/obo/HP_0004026		
GO:0046916	biolink:BiologicalProcess	cellular transition metal ion homeostasis	Any process involved in the maintenance of an internal steady state of transition metal ions at the level of a cell. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.		hp.json		http://purl.obolibrary.org/obo/GO_0046916		
HP:0004025	biolink:PhenotypicFeature	Spurred radial metaphysis		UMLS:C4025435	hp.json		http://purl.obolibrary.org/obo/HP_0004025		
HP:0006687	biolink:PhenotypicFeature	Aortic tortuosity	Abnormal tortuous (i.e., twisted) form of the aorta.	UMLS:C4025003	hp.json		http://purl.obolibrary.org/obo/HP_0006687		
HP:0031698	biolink:PhenotypicFeature	obsolete Disseminated Bacillus Calmette-Guerin infection	Failure to contain thebacillus Calmette-Guerin (BCG) following vaccination leading to spread of BCG to many sites in the body. The tuberculosis vaccine BCG contains live attenuated Mycobacterium bovis.		hp.json		http://purl.obolibrary.org/obo/HP_0031698		
GO:0046914	biolink:MolecularActivity	transition metal ion binding	Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.		hp.json		http://purl.obolibrary.org/obo/GO_0046914		
HP:0006688	biolink:PhenotypicFeature	Paroxysmal tachycardia		SNOMEDCT_US:12026006|UMLS:C0039236|MSH:D013614	hp.json		http://purl.obolibrary.org/obo/HP_0006688		
HP:0031699	biolink:PhenotypicFeature	Disseminated cryptosporidium infection	Failure to contain infection by a protozoan of the genus Cryptosporidium, leading to spread to many parts of the body.		hp.json		http://purl.obolibrary.org/obo/HP_0031699		
HP:0006689	biolink:PhenotypicFeature	Bacterial endocarditis	A bacterial infection of the endocardium, the inner layer of the heart, which usually involves the heart valves.	MSH:D004697|SNOMEDCT_US:301183007|UMLS:C0014121	hp.json	Infective endocarditis	http://purl.obolibrary.org/obo/HP_0006689		
HP:0004029	biolink:PhenotypicFeature	Lytic defects of radial diaphysis		UMLS:C4025432	hp.json		http://purl.obolibrary.org/obo/HP_0004029		
HP:0006683	biolink:PhenotypicFeature	Abnormal ventricular filling	An abnormality of filling of a ventricle with blood during diastole.	UMLS:C4025005	hp.json		http://purl.obolibrary.org/obo/HP_0006683		
GO:0032368	biolink:BiologicalProcess	regulation of lipid transport	Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0032368		
HP:0004020	biolink:PhenotypicFeature	Irregular ossification of the radial metaphysis		UMLS:C4025440	hp.json		http://purl.obolibrary.org/obo/HP_0004020		
HP:0006684	biolink:PhenotypicFeature	Ventricular preexcitation with multiple accessory pathways	A form of ventricular preexcitation due to the presence of multiple accessory pathways for cardiac conduction.	UMLS:C4025004	hp.json		http://purl.obolibrary.org/obo/HP_0006684		
HP:0006685	biolink:PhenotypicFeature	Endocardial fibrosis	The presence of excessive connective tissue in the endocardium.	MSH:D004719|UMLS:C0553980|SNOMEDCT_US:398716006	hp.json	Endomyocardial fibrosis	http://purl.obolibrary.org/obo/HP_0006685		
GO:0032365	biolink:BiologicalProcess	intracellular lipid transport	The directed movement of lipids within cells.		hp.json		http://purl.obolibrary.org/obo/GO_0032365		
HP:0004024	biolink:PhenotypicFeature	Medially sloping radial metaphysis		UMLS:C4025436	hp.json		http://purl.obolibrary.org/obo/HP_0004024		
GO:0032364	biolink:BiologicalProcess	oxygen homeostasis	A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell.		hp.json		http://purl.obolibrary.org/obo/GO_0032364		
HP:0004023	biolink:PhenotypicFeature	Sloping radial metaphysis		UMLS:C4025437	hp.json		http://purl.obolibrary.org/obo/HP_0004023		
HP:0004022	biolink:PhenotypicFeature	Sclerotic radial metaphysis with longitudinal striations		UMLS:C4025438	hp.json		http://purl.obolibrary.org/obo/HP_0004022		
HP:0006681	biolink:PhenotypicFeature	Absent atrioventricular node		UMLS:C4025006	hp.json		http://purl.obolibrary.org/obo/HP_0006681		
HP:0006682	biolink:PhenotypicFeature	Premature ventricular contraction	Premature ventricular contractions (PVC) or ventricular extrasystoles are premature contractions of the heart that arise in response to an impulse in the ventricles rather than the normal impulse from the sinoatrial (SA) node.	SNOMEDCT_US:17338001|UMLS:C0151636|MSH:D018879|SNOMEDCT_US:251175005	hp.json	Skipped heartbeat|Ventricular premature beat|Premature ventricular beat|Missed heartbeat|Extra heart beat|Premature ventricular contractions|Ventricular extrasystoles|Ventricular ectopics	http://purl.obolibrary.org/obo/HP_0006682		
HP:0004021	biolink:PhenotypicFeature	Lytic defects of radial metaphysis		UMLS:C4025439	hp.json		http://purl.obolibrary.org/obo/HP_0004021		
PATO:0000969	biolink:NamedThing	dwarf-like	A size quality inhering in a bearer by virtue of the bearer's being abnormally small.		hp.json	dwarfed	http://purl.obolibrary.org/obo/PATO_0000969		value_slim
PATO:0000963	biolink:NamedThing	opaque	A optical quality inhering in a bearer by virtue of the bearer's not being clear; not transmitting or reflecting light or radiant energy.		hp.json	cloudy|clouding|non-transparent	http://purl.obolibrary.org/obo/PATO_0000963		value_slim|mpath_slim
GO:0007399	biolink:BiologicalProcess	nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.		hp.json	pan-neural process	http://purl.obolibrary.org/obo/GO_0007399		goslim_drosophila
HP:0031620	biolink:PhenotypicFeature	Anterior chamber flare grade 3+	Marked anterior chamber flare (iris and lens details hazy).		hp.json		http://purl.obolibrary.org/obo/HP_0031620		
GO:0007398	biolink:BiologicalProcess	ectoderm development	The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.		hp.json		http://purl.obolibrary.org/obo/GO_0007398		
PATO:0000965	biolink:NamedThing	symmetry	A pattern quality of inhering in a bearer by virtue of the correspondence in size, shape, and relative position of the bearer's parts on opposite sides of a dividing line or median plane or about a center or axis.		hp.json		http://purl.obolibrary.org/obo/PATO_0000965		attribute_slim
PATO:0000964	biolink:NamedThing	transparent	A optical quality inhering in a bearer by virtue of the bearer's lacking opacity.		hp.json	clear|hyaline	http://purl.obolibrary.org/obo/PATO_0000964		value_slim|mpath_slim
PATO:0000967	biolink:NamedThing	undulate	A shape quality inhering in a bearer by virtue of the bearer's having a sinuate margin and rippled surface.		hp.json	sinuate|rippled|wavy|undulating|waved|undulated	http://purl.obolibrary.org/obo/PATO_0000967		value_slim|mpath_slim|cell_quality
HP:0031625	biolink:PhenotypicFeature	Pseudoaneurysm	A contained rupture of an artery with a disruption in all 3 layers of the arterial wall.		hp.json		http://purl.obolibrary.org/obo/HP_0031625		
HP:0031626	biolink:PhenotypicFeature	Coronary ostial atresia	Absence of the normal opening of a coronary ostium. There are normally two coronary ostia, which are site of origin of the main left or right main coronary artery and are located in the ascending aorta just above the aortic valve.		hp.json	Atresia of coronary ostium	http://purl.obolibrary.org/obo/HP_0031626		
HP:0031627	biolink:PhenotypicFeature	Globus pallidus calcification	Pathological deposition of calcium salts in the globus pallidus.		hp.json		http://purl.obolibrary.org/obo/HP_0031627		
HP:0031628	biolink:PhenotypicFeature	Aborted sudden cardiac death	Cardiac arrest that would have led to rapid and unexpected death had an intervention not taken place to prevent it.		hp.json	Sudden cardiac arrest	http://purl.obolibrary.org/obo/HP_0031628		
HP:0031621	biolink:PhenotypicFeature	Anterior chamber flare grade 4+	Intense anterior chamber flare (fibrin/plastic aqueous).		hp.json		http://purl.obolibrary.org/obo/HP_0031621		
HP:0031622	biolink:PhenotypicFeature	Brown anomaly	An ocular motility defect where the affected eye(s) does not elevate in adduction but has full depression in adduction. It can be congenital or acquired from injury to or defect of the superior oblique tendon or trochlea and has a positive forced duction test result.		hp.json	Brown syndrome	http://purl.obolibrary.org/obo/HP_0031622		
OIO:inSubset	biolink:NamedThing	in_subset			hp.json		http://www.geneontology.org/formats/oboInOwl#inSubset		
HP:0031623	biolink:PhenotypicFeature	Brow ptosis	Drooping of the upper eyebrow below the superior orbital rim.		hp.json	Drooping brow	http://purl.obolibrary.org/obo/HP_0031623		
HP:0031624	biolink:PhenotypicFeature	Moderate myopia	A moderate form of myopia with refractive error of between -3.00 and -6.00 diopters.		hp.json		http://purl.obolibrary.org/obo/HP_0031624		
HP:0031629	biolink:PhenotypicFeature	Impaired tandem gait	Reduced ability to walk in a straight line while placing the feet heel to toe.		hp.json	Clumsy tandem walking	http://purl.obolibrary.org/obo/HP_0031629		
GO:0032353	biolink:NamedThing	negative regulation of hormone biosynthetic process			hp.json		http://purl.obolibrary.org/obo/GO_0032353		
GO:0032352	biolink:NamedThing	positive regulation of hormone metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0032352		
GO:0032351	biolink:NamedThing	negative regulation of hormone metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0032351		
GO:0032350	biolink:NamedThing	regulation of hormone metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0032350		
HP:0004090	biolink:PhenotypicFeature	obsolete Advanced maturation/advanced ossification of terminal thumb phalanx epiphysis			hp.json		http://purl.obolibrary.org/obo/HP_0004090		
HP:0031630	biolink:PhenotypicFeature	Abnormal subpleural morphology	Any structural anomaly located between the pleura and the chest wall.		hp.json		http://purl.obolibrary.org/obo/HP_0031630		
HP:0031631	biolink:PhenotypicFeature	Subpleural honeycombing	So-called honeycombs (variably sized cysts in a background of densely scarred tissue) located in the subpleural space.		hp.json		http://purl.obolibrary.org/obo/HP_0031631		
HP:0031636	biolink:PhenotypicFeature	Anomalous origin of the right common carotid artery from the aorta	The right common carotid artery normally originates from the brachiocephalic artery. This term refers to an origin of this artery directly from the aorta.		hp.json		http://purl.obolibrary.org/obo/HP_0031636		
GO:0046939	biolink:BiologicalProcess	nucleotide phosphorylation	The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside.		hp.json		http://purl.obolibrary.org/obo/GO_0046939		
HP:0031637	biolink:PhenotypicFeature	Right coronary artery ostial atresia	Absence of the normal opening of the coronary ostium from which the right main coronary artery originates.		hp.json		http://purl.obolibrary.org/obo/HP_0031637		
HP:0031638	biolink:PhenotypicFeature	Anomalous origin of the left anterior descending artery from the pulmonary artery	The left anterior descending artery (LAD) branches off from the pulmonary artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031638		
HP:0031639	biolink:PhenotypicFeature	Absent left main coronary artery	The left main coronary artery (LMCA) is absent and the left anterior descending (LAD) and left circumflex (LCX) arteries arise from separate but adjacent ostia in the left sinus of Valsava.		hp.json	Absent LMCA	http://purl.obolibrary.org/obo/HP_0031639		
HP:0031632	biolink:PhenotypicFeature	Anomalous origin of the right subclavian artery from the descending aorta	Abnormal origin of the right subclavian artery from the descending aorta. The right subclavian artery normally arises from the brachiocephalic trunk, which divides into the right common carotid artery and right subclavian artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031632		
HP:0031633	biolink:PhenotypicFeature	Isolation of the left subclavian artery	The loss of continuity between the left subclavian artery and the aorta, with persistent connection to the homolateral pulmonary artery through the patent (PDA) or nonpatent ductus arteriosus.	Fyler:2732	hp.json		http://purl.obolibrary.org/obo/HP_0031633		
HP:0031634	biolink:PhenotypicFeature	Anomalous origin of the left common carotid artery from the main pulmonary artery	The left common carotid artery normally originates from the aortic arch. This term refers to an origin of this artery from the main pulmonary artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031634		
HP:0031635	biolink:PhenotypicFeature	Anomalous origin of the left common carotid artery from the brachiocephalic artery	The left common carotid artery normally originates from the aortic arch. This term refers to an origin of this artery from the brachiocephalic artery.		hp.json	Anomalous origin of the left common carotid artery from the brachiocephalic trunk	http://purl.obolibrary.org/obo/HP_0031635		
HP:0004083	biolink:PhenotypicFeature	obsolete Laterally deviated terminal thumb phalanx			hp.json		http://purl.obolibrary.org/obo/HP_0004083		
HP:0004060	biolink:PhenotypicFeature	Trident hand	A hand in which the fingers are of nearly equal length and deflected at the first interphalangeal joint, so as to give a forklike shape consisting of separation of the first and second as well as the third and fourth digits.	UMLS:C0426874|SNOMEDCT_US:249755001	hp.json	trident abnormality|trident deformity	http://purl.obolibrary.org/obo/HP_0004060		hposlim_core
HP:0031640	biolink:PhenotypicFeature	Abnormal radial artery morphology	Any structural anomaly of the radial artery.		hp.json		http://purl.obolibrary.org/obo/HP_0031640		
GO:0046942	biolink:BiologicalProcess	carboxylic acid transport	The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).		hp.json		http://purl.obolibrary.org/obo/GO_0046942		
HP:0031647	biolink:PhenotypicFeature	Saccular aortic arch aneurysm	An eccentric abnormal localized widening (dilatation) of the aortic arch that involves only a portion of the circumference of the vessel wall.		hp.json		http://purl.obolibrary.org/obo/HP_0031647		
HP:0031648	biolink:PhenotypicFeature	Penetrating aortic ulcer	A focal defect in the elastic lamina of the aortic wall that leads to localized medial disruption and potential rupture.		hp.json		http://purl.obolibrary.org/obo/HP_0031648		
HP:0031649	biolink:PhenotypicFeature	Aortic rupture	Tearing of the aortic wall generally associated with profuse internal bleeding.		hp.json		http://purl.obolibrary.org/obo/HP_0031649		
HP:0004059	biolink:PhenotypicFeature	Radial club hand	Wrist is bent inward toward the thumb because of a congenital defect associated with shortening or absence of the radius.	UMLS:C4025414	hp.json		http://purl.obolibrary.org/obo/HP_0004059		
HP:0004058	biolink:PhenotypicFeature	Hand monodactyly		UMLS:C4025415	hp.json		http://purl.obolibrary.org/obo/HP_0004058		
HP:0031643	biolink:PhenotypicFeature	Fusiform ascending tubular aorta aneurysm	A concentric abnormal localized widening (dilatation) of the ascending tubular aorta that involves the full circumference of the vessel wall.		hp.json		http://purl.obolibrary.org/obo/HP_0031643		
HP:0031644	biolink:PhenotypicFeature	Fusiform abdominal aortic aneurysm	A concentric abnormal localized widening (dilatation) of the abdominal aorta that involves the full circumference of the vessel wall		hp.json		http://purl.obolibrary.org/obo/HP_0031644		
HP:0031645	biolink:PhenotypicFeature	Saccular abdominal aortic aneurysm	An eccentric abnormal localized widening (dilatation) of the abdominal aorta that involves only a portion of the circumference of the vessel wall.		hp.json		http://purl.obolibrary.org/obo/HP_0031645		
HP:0031646	biolink:PhenotypicFeature	Fusiform aortic arch aneurysm	A concentric abnormal localized widening (dilatation) of the aortic arch that involves the full circumference of the vessel wall.		hp.json		http://purl.obolibrary.org/obo/HP_0031646		
HP:0004053	biolink:PhenotypicFeature	Dysharmonic maturation of the hand bones	Pattern of hand-wrist development does not fit the normal sequence of ossification of the individual bones of the hand.	UMLS:C4021685	hp.json	Dysharmonic ossification of the hand bones|Disharmonic maturation of the hand bones	http://purl.obolibrary.org/obo/HP_0004053		
HP:0004052	biolink:PhenotypicFeature	Delayed ossification of the hand bones	Ossification of hand bones is less advanced than would be expected according to age-adjusted norms.	UMLS:C4020833|UMLS:C4021686	hp.json	Delay maturation/delayed ossification of the hand|Delayed maturation of the hand bones	http://purl.obolibrary.org/obo/HP_0004052		
HP:0004051	biolink:PhenotypicFeature	Advanced ossification of the hand bones	Ossification of hand bones at an earlier age than normal.	UMLS:C4020834	hp.json	Advanced maturation of the hand bones|Accelerated maturation of hand bones	http://purl.obolibrary.org/obo/HP_0004051		
GO:0032332	biolink:BiologicalProcess	positive regulation of chondrocyte differentiation	Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.		hp.json	activation of chondrocyte differentiation|stimulation of chondrocyte differentiation|upregulation of chondrocyte differentiation|up-regulation of chondrocyte differentiation|up regulation of chondrocyte differentiation	http://purl.obolibrary.org/obo/GO_0032332		
HP:0004050	biolink:PhenotypicFeature	Absent hand	The total absence of the hand, with no bony elements distal to the radius or ulna.	UMLS:C0265594|SNOMEDCT_US:371199008	hp.json	Acheiria|Absent hand	http://purl.obolibrary.org/obo/HP_0004050		hposlim_core
HP:0004057	biolink:PhenotypicFeature	Mitten deformity	Fusion of the hands and feet by a thin membrane of skin (scarring) seen in forms of dystrophic epidermolysis bullosa and leading to a "mitten" hand deformity.	UMLS:C1969236	hp.json	Pseudosyndactyly	http://purl.obolibrary.org/obo/HP_0004057		
GO:0032331	biolink:BiologicalProcess	negative regulation of chondrocyte differentiation	Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.		hp.json	down-regulation of chondrocyte differentiation|down regulation of chondrocyte differentiation|inhibition of chondrocyte differentiation|downregulation of chondrocyte differentiation	http://purl.obolibrary.org/obo/GO_0032331		
GO:0032330	biolink:BiologicalProcess	regulation of chondrocyte differentiation	Any process that modulates the frequency, rate or extent of chondrocyte differentiation.		hp.json		http://purl.obolibrary.org/obo/GO_0032330		
HP:0004054	biolink:PhenotypicFeature	Sclerosis of hand bone	Osteosclerosis affecting one or more bones of the hand.	UMLS:C4021684	hp.json	Hand bone sclerosis|Increased bone density in hand bone|Generalized sclerosis of hand bones|Increased bone density in hand bones|Generalised sclerosis of hand bones	http://purl.obolibrary.org/obo/HP_0004054		
HP:0031650	biolink:PhenotypicFeature	Abnormal atrioventricular valve physiology	Any functional defect of the mitral or tricuspid valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031650		
GO:0007389	biolink:BiologicalProcess	pattern specification process	Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.		hp.json	pattern formation|pattern biosynthesis	http://purl.obolibrary.org/obo/GO_0007389		goslim_drosophila
HP:0031651	biolink:PhenotypicFeature	Abnormal tricuspid valve physiology	Any functional defect of the tricuspid valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031651		
HP:0031652	biolink:PhenotypicFeature	Abnormal aortic valve physiology			hp.json		http://purl.obolibrary.org/obo/HP_0031652		
GO:0046951	biolink:BiologicalProcess	ketone body biosynthetic process	The chemical reactions and pathways resulting in the formation of ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone. Biosynthesis involves the formation of hydroxymethylglutaryl-CoA, which is cleaved to acetate and acetyl-CoA.		hp.json	ketone body anabolism|ketone body synthesis|ketone body formation|ketone body biosynthesis	http://purl.obolibrary.org/obo/GO_0046951		
HP:0031653	biolink:PhenotypicFeature	Abnormal heart valve physiology	Any functional abnormality of a cardiac valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031653		
GO:0046950	biolink:BiologicalProcess	cellular ketone body metabolic process	The chemical reactions and pathways involving ketone bodies, any one of the three substances: acetoacetate, D-3-hydroxybutyrate (beta-hydroxybutyrate) or acetone, as carried out by individual cells. Although 3-hydroxybutyrate is not a ketone, it is classed as a ketone body because it exists in an equilibrium with acetoacetate. Ketone bodies may accumulate in excessive amounts in the body in starvation, diabetes mellitus or in other defects of carbohydrate metabolism.		hp.json	cellular ketone body metabolism	http://purl.obolibrary.org/obo/GO_0046950		goslim_pir
PATO:0000998	biolink:NamedThing	viscous	A viscosity quality inhering in a bearer by virtue of the bearer's having viscosity.		hp.json		http://purl.obolibrary.org/obo/PATO_0000998		disposition_slim|value_slim|mpath_slim
HP:0031658	biolink:PhenotypicFeature	Third heart sound	The third heart sound (S3) is related to rapid filling in diastole. S3 can be a normal finding in children and adolescents but suggests heart failure in older patients.		hp.json	S3|Ventricular gallop	http://purl.obolibrary.org/obo/HP_0031658		
HP:0031659	biolink:PhenotypicFeature	Fourth heart sound	The fourth heart sound (S4) is a low-pitched sound that occurs just before the first heart sound (S1) when the atria contract to force blood into the left ventricle, that is, coincident with late diastolic filling of the ventricle due to atrial contraction.		hp.json	S4|Presystolic gallop|Atrial gallop	http://purl.obolibrary.org/obo/HP_0031659		
HP:0031654	biolink:PhenotypicFeature	Abnormal pulmonary valve physiology	Any functional anomaly of the pumonary valve.		hp.json		http://purl.obolibrary.org/obo/HP_0031654		
HP:0031655	biolink:PhenotypicFeature	Quadricuspid aortic valve	The presence of an aortic valve with four instead of the normal three cusps (flaps).		hp.json		http://purl.obolibrary.org/obo/HP_0031655		
PATO:0000992	biolink:NamedThing	viscosity	A physical quality of a fluid inhering in a bearer by virtue of the bearer's disposition to internal resistance to flow.		hp.json		http://purl.obolibrary.org/obo/PATO_0000992		attribute_slim|disposition_slim
HP:0031656	biolink:PhenotypicFeature	Systolic anterior motion of the mitral valve	Systolic anterior motion of the mitral valve (SAM) is a paradoxical motion of the anterior, and occasionally posterior, mitral valve leaflet towards the left ventricular outflow tract (LVOT) during systole.		hp.json		http://purl.obolibrary.org/obo/HP_0031656		
HP:0031657	biolink:PhenotypicFeature	Abnormal heart sound	Any abnormal noise generated by the beating heart.		hp.json		http://purl.obolibrary.org/obo/HP_0031657		
HP:0004066	biolink:PhenotypicFeature	obsolete Laterally deviated thumb phalanges			hp.json		http://purl.obolibrary.org/obo/HP_0004066		
PATO:0000927	biolink:NamedThing	photosensitivity	A quality inhering in a bearer by virtue of the bearer's disposition to being sensitivity to the action of radiant energy.		hp.json		http://purl.obolibrary.org/obo/PATO_0000927		attribute_slim|scalar_slim|disposition_slim
PATO:0000921	biolink:NamedThing	width	A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite.		hp.json	breadth	http://purl.obolibrary.org/obo/PATO_0000921		scalar_slim|attribute_slim
HP:0006619	biolink:PhenotypicFeature	Anterior rib punctate calcifications	Deposition of calcium salts in point-like foci within the anterior portion of one or more ribs.	UMLS:C1859120	hp.json		http://purl.obolibrary.org/obo/HP_0006619		
HP:0006615	biolink:PhenotypicFeature	Absent in utero rib ossification	Lack of formation and mineralization of the ribs in utero.	UMLS:C1842695	hp.json	Absent rib calcification in utero	http://purl.obolibrary.org/obo/HP_0006615		
HP:0006610	biolink:PhenotypicFeature	Wide intermamillary distance	A larger than usual distance between the left and right nipple.	SNOMEDCT_US:423230008|UMLS:C1827524	hp.json	Widely spaced nipples|Widely-spaced nipples|Wide-spaced nipples	http://purl.obolibrary.org/obo/HP_0006610		hposlim_core
HP:0006611	biolink:PhenotypicFeature	Decreased number of sternal ossification centers	A less than normal number of sternal ossification centers. The sternum is initially formed from bilateral sternal plates that chondrify and begin to fuse with ribs at 10 weeks gestational age. Ossification starts in the manubrium and upper part of the sternal body at the 6th month, in the middle of the sternal body at the 7th month, in the lower part of the body during the 1st postnatal year and in the xiphoid process between years 5 and 18. The number of ossification centers vary up to six, and it is the ossification centers that are visualized by prenatal ultrasound. This term describes a reduction in the number of ossification centers compared with age-related norms.	UMLS:C1856223	hp.json	Decreased number of sternal ossification centres	http://purl.obolibrary.org/obo/HP_0006611		
UBERON:0002195	biolink:AnatomicalEntity	trabecula of lymph node	Membranous process coming from capsule of lymph node[WP].	NCIT:C33035|UMLS:C1184179|MA:0000746|FMA:74605	hp.json	lymph node trabecula|lymph node trabeculae|trabeculae of lymph node|lymph node trabeculum	http://purl.obolibrary.org/obo/UBERON_0002195		pheno_slim|human_reference_atlas
HP:0006625	biolink:PhenotypicFeature	Multifocal breast carcinoma	Breast carcinoma that is bilateral or otherwise multifocal.	UMLS:C2986662	hp.json	Multifocal breast cancer	http://purl.obolibrary.org/obo/HP_0006625		
UBERON:0002194	biolink:AnatomicalEntity	capsule of lymph node	Capsule surrounding lymph node composed of connective tissue with some plain muscle fibers.	NCIT:C33028|FMA:74604|UMLS:C0229699|MA:0000739|EMAPA:35524	hp.json	lymph node capsule|capsula nodi lymphoidei	http://purl.obolibrary.org/obo/UBERON_0002194		human_reference_atlas|uberon_slim
UBERON:0002196	biolink:AnatomicalEntity	adenohypophysis	The glandular, anterior lobe of the pituitary gland. The anterior pituitary regulates several physiological processes including stress, growth, and reproduction[WP]. The anterior lobe of the hypophysis (pituitary gland). This lobe contains cells that produce prolactin, growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone and proopiomelanocortin[ZFA].	VHOG:0000141|FMA:74627|BAMS:AHY|UMLS:C0032008|UMLS:C1280369|BIRNLEX:1581|MA:0000177|NCIT:C12772|AAO:0010540|UMLS:C0032008|ZFA:0001282|MESH:D010903|TAO:0001282|BM:AHy|EFO:0000230|EMAPA:17514|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=407|EHDAA2:0000109|BAMS:AL|CALOHA:TS-0794|BAMS:APit|BTO:0000040	hp.json	anterior lobe of pituitary gland|pituitary anterior lobe|anterior lobe of pituitary|anterior pituitary gland|lobus anterior hypophysis|anterior lobe of the pituitary|anterior pituitary|cranial lobe|anterior lobe (hypophysis)|AHP|pituitary glandanterior lobe|pituitary gland, anterior lobe|anterior lobe of hypophysis|lobus anterior|lobus anterior (glandula pituitaria)|anterior hypophysis|rostral lobe	http://purl.obolibrary.org/obo/UBERON_0002196		vertebrate_core|pheno_slim|efo_slim|uberon_slim
HP:0006628	biolink:PhenotypicFeature	Absent sternal ossification	Lack of formation of mineralized bony tissue of the sternum.	UMLS:C4280443|UMLS:C1857074	hp.json	Lack of sternal ossification|Absent sternal mineralization|Absent bone maturation in sternum	http://purl.obolibrary.org/obo/HP_0006628		
UBERON:0002191	biolink:AnatomicalEntity	subiculum	Part of the hippocampal formation that is bounded by the entorhinal cortex and area CA1. It is characterized on the CA1 border by an abrupt widening of the pyramidal cell layer. A molecular layer is present that is continuous with that of CA1, although the stratum radiatum is no longer present. The stratum oriens is also not present. adapted from Paxinos, G. The rat central nervous system, 2nd ed, Academic Press, San Diego, 1995, pg. 468).	BAMS:SUB|FMA:74414|MBA:502|DMBA:16163|BM:Tel-Cx-SB|EMAPA:35832|PBA:10054|BIRNLEX:1305|NCIT:C33648|HBA:12896|BTO:0003087|DHBA:10302|BAMS:S|UMLS:C0152316|DHBA:10301|MA:0000960|PBA:128012354	hp.json	subicular cortex|subiculum hippocampi|gyrus parahippocampalis|subiculum cornu ammonis	http://purl.obolibrary.org/obo/UBERON_0002191		pheno_slim|uberon_slim
UBERON:0002190	biolink:AnatomicalEntity	subcutaneous adipose tissue	A portion of adipose tissue that is part of the hypodermis, beneath the dermis.	FMA:74315|MA:0000473|BTO:0004042|EMAPA:35829	hp.json	panniculus adiposus|subcutaneous fat layer|hypodermis fat layer|panniculus adiposus (tela subcutanea)|panniculus adiposus telae subcutaneae|subcutaneous fat|fatty layer of superficial fascia|fatty layer of subcutaneous tissue	http://purl.obolibrary.org/obo/UBERON_0002190		pheno_slim|human_reference_atlas
UBERON:0002193	biolink:AnatomicalEntity	hemolymphoid system	Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs.	MA:0000013|FMA:74562|CALOHA:TS-2018|EMAPA:18765|EHDAA2:0004615	hp.json	haemolymphoid system|hematolymphoid system|lymphomyeloid complex	http://purl.obolibrary.org/obo/UBERON_0002193		
HP:0006623	biolink:PhenotypicFeature	Costochondral joint sclerosis	Abnormal increase in density of the tissue at the costochondral junctions.	UMLS:C4021588	hp.json	Sclerotic costochondral joints	http://purl.obolibrary.org/obo/HP_0006623		
UBERON:0002199	biolink:AnatomicalEntity	integument	The dermis, epidermis and hypodermis.	TAO:0000368|AAO:0000239|EMAPA:37504|FMA:74657|BTO:0000634|VSAO:0000029|Wikipedia:Integument|galen:Integument|ZFA:0000368	hp.json	tegument|vertebrate integument|dermal system|skin|skin plus hypodermis|the integument|integumentum commune|dermis plus epidermis plus hypodermis|dermoid system|skin and subcutaneous tissue	http://purl.obolibrary.org/obo/UBERON_0002199		vertebrate_core|pheno_slim|uberon_slim
UBERON:0002198	biolink:AnatomicalEntity	neurohypophysis	The posterior part of the pituitary gland that secretes hormones involved in blood pressure regulation such as oxytocin and antidiuretic hormon.	VHOG:0000142|AAO:0010537|FMA:74628|UMLS:C0032009|MA:0000178|EHDAA:7536|BAMS:NHY|CALOHA:TS-0815|BM:NY|NCIT:C12773|DMBA:15691|EMAPA:17519|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=401|ZFA:0001271|MESH:D010904|UMLS:C1280368|BAMS:NL|TAO:0001271|UMLS:C0032009|EHDAA2:0001271|BAMS:NHP|BAMS:PPit|BIRNLEX:1586|BTO:0000937	hp.json	pituitary gland, posterior lobe|lobus nervosus|lobus nervosus neurohypophysis|lobus posterior (glandula pituitaria)|NHP|infundibular process|lobus posterior|neural lobe|lobus posterior hypophysis|posterior lobe of pituitary gland|neural lobe of pituitary gland|neurohypophysis|pituitary gland neural lobe|neural lobe of pituitary|posterior lobe of pituitary|pituitary gland, neural lobe|posterior pituitary|posterior lobe of hypophysis|neuro hypophysis|posterior pituitary gland	http://purl.obolibrary.org/obo/UBERON_0002198		vertebrate_core|pheno_slim|uberon_slim
PATO:0000947	biolink:NamedThing	elliptic	A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section.		hp.json	ellipsoid|ellipse-shaped|ovoid|oval|elliptical	http://purl.obolibrary.org/obo/PATO_0000947		mpath_slim|cell_quality|value_slim
PATO:0000946	biolink:NamedThing	oblong	A shape quality inhering in a bearer by virtue of the bearer's having a somewhat elongated form with approximately parallel sides.		hp.json		http://purl.obolibrary.org/obo/PATO_0000946		mpath_slim|cell_quality|value_slim
PATO:0000941	biolink:NamedThing	vacuolated	A structural quality inhering in a cytoplasm that contains fluid filled cavities.		hp.json		http://purl.obolibrary.org/obo/PATO_0000941		cell_quality|value_slim|mpath_slim
PATO:0000944	biolink:NamedThing	sharpness	A shape quality inhering in a bearer by virtue of the bearer's having a sharp or tapered end or point.		hp.json	apiculate	http://purl.obolibrary.org/obo/PATO_0000944		cell_quality|attribute_slim
HP:0031603	biolink:PhenotypicFeature	Impaired nasal mucociliary clearance	An abnormally increased amount of time required to clear mucus (and substances contained in the mucus) from the nasal mucosa. The nasal mucociliary clearance (NMC) system functions to transport the mucous layer lining the nasal epithelium towards the naso pharynx by ciliary beating in a metachronous fashion at a frequency of 7-16 Hz. NMC depends upon two principal components: physicochemical qualities and quantities of mucus and the properties of cilia that propel it. NMC is considered to be representative of pulmonary clearance. normal NMC time is determined to be up to 20 minutes. Duration of 30 minutes is considered as the cutoff point that discriminates normal subjects from subjects with impaired NMC. NMC can be measured by determination of the transport time of markers that are placed on the nasal mucosa including saccharine, radioactive markers, and dyes.		hp.json	Abnormal saccharine test	http://purl.obolibrary.org/obo/HP_0031603		
HP:0031604	biolink:PhenotypicFeature	Agenesis of the carotid canal	A developmental defect characterized by the lack of formation of the carotid canal, which normally is a circular aperture in the temporal bone of the skull through which the internal carotid artery and the carotid plexus of nerves traverse.		hp.json	Bony carotid canal agenesis	http://purl.obolibrary.org/obo/HP_0031604		
UBERON:0002186	biolink:AnatomicalEntity	bronchiole	The conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching.	MESH:D055745|CALOHA:TS-2003|MA:0000422|EHDAA:8183|EHDAA:8171|FMA:7410|NCIT:C12684|UMLS:C0006270|EMAPA:32697|OpenCyc:Mx4rvl9iDpwpEbGdrcN5Y29ycA|VHOG:0000675|BTO:0002375|EHDAA:8221|EHDAA:8199	hp.json	bronchiolus|bronchioli|lobular bronchiole	http://purl.obolibrary.org/obo/UBERON_0002186		pheno_slim|uberon_slim
HP:0031605	biolink:PhenotypicFeature	Abnormality of fundus pigmentation	Any anomaly of the pigmentation of the fundus, the posterior part of the eye including the retina and optic nerve.		hp.json		http://purl.obolibrary.org/obo/HP_0031605		
UBERON:0002185	biolink:AnatomicalEntity	bronchus	The upper conducting airways of the lung; these airways arise from the terminus of the trachea.	VHOG:0000262|UMLS:C0006255|EFO:0000932|XAO:0000121|EMAPA:32689|MESH:D001980|NCIT:C12683|MAT:0000133|FMA:7409|CALOHA:TS-1229|MIAA:0000133|EV:0100041|MA:0000436|BTO:0001340|GAID:346	hp.json	bronchial tissue|bronchial trunk|bronchi	http://purl.obolibrary.org/obo/UBERON_0002185		organ_slim|pheno_slim|efo_slim|uberon_slim
HP:0031606	biolink:PhenotypicFeature	Retinal cotton wool spot	Fluffy white patch on the retina, representing localized areas of dense white swelling of the retinal nerve fibre layer. They often have a zigzag internal structure, a feathered edge but an otherwise well-delineated form and an approximately 1 mm dimension; they project slightly into the vitreous and sometimes deflect retinal vessels.		hp.json		http://purl.obolibrary.org/obo/HP_0031606		
UBERON:0002180	biolink:AnatomicalEntity	ventral funiculus of spinal cord	The white substance of the spinal cord lying on either side between the ventral median fissure and the ventral roots of the spinal nerves.	ZFA:0000605|FMA:74003|NLX:379|TAO:0000605	hp.json	anterior white column of spinal cord|ventral white column of spinal cord|anterior funiculus|funiculus anterior medullae spinalis|ventral funiculus of spinal cord|ventral funiculi|anterior funiculus of spinal cord|ventral funiculus	http://purl.obolibrary.org/obo/UBERON_0002180		uberon_slim|vertebrate_core
HP:0031600	biolink:PhenotypicFeature	P wave inversion	P wave below instead of above the baseline. P-wave inversion in the inferior leads may indicate a non-sinus origin of the P waves.		hp.json		http://purl.obolibrary.org/obo/HP_0031600		
HP:0031601	biolink:PhenotypicFeature	P pulmonale	The presence of tall, peaked P waves in EKG lead II.		hp.json		http://purl.obolibrary.org/obo/HP_0031601		
HP:0031602	biolink:PhenotypicFeature	Abnormal mucociliary clearance	An anomaly in the system of mucociliary transport, which functions to transport the mucous layer lining the respiratory epithelium by ciliary  beating.		hp.json	Abnormal mucociliary transport	http://purl.obolibrary.org/obo/HP_0031602		
HP:0031607	biolink:PhenotypicFeature	Pelvic organ prolapse	Weakness in the supporting structures of the pelvic floor allowing the pelvic viscera to descend or one or more of the pelvic organs drop from their normal position.		hp.json		http://purl.obolibrary.org/obo/HP_0031607		
UBERON:0002187	biolink:AnatomicalEntity	terminal bronchiole	The last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls.	MA:0000424|OpenCyc:Mx4rwS7IU5wpEbGdrcN5Y29ycA|FMA:7411|NCIT:C33754|EMAPA:36282|UMLS:C0225666|BTO:0003223	hp.json	bronchioli terminalis|bronchiolus terminalis|terminal bronchiole tube	http://purl.obolibrary.org/obo/UBERON_0002187		uberon_slim|pheno_slim|human_reference_atlas
HP:0031609	biolink:PhenotypicFeature	Geographic atrophy	Sharply demarcated area of partial or complete depigmentation of the fundus reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss. The margins of the de-pigmented area are usually scalloped and the large choroidal vessels are visible through the atrophic retinal pigment epithelium.		hp.json		http://purl.obolibrary.org/obo/HP_0031609		
PATO:0000957	biolink:NamedThing	opacity	An optical quality which obtains by virtue of the ability of the bearer to absorb visible light.		hp.json		http://purl.obolibrary.org/obo/PATO_0000957		attribute_slim
PATO:0000950	biolink:NamedThing	grey	A color between white and black colors.		hp.json	plumbeous	http://purl.obolibrary.org/obo/PATO_0000950		value_slim|mpath_slim
HP:0006607	biolink:PhenotypicFeature	Precocious costochondral ossification	Early ossification of the costochondral junction, which is the joint between the ribs and costal cartilage in the front of the rib cage.	UMLS:C1849049	hp.json		http://purl.obolibrary.org/obo/HP_0006607		
HP:0006608	biolink:PhenotypicFeature	Midclavicular hypoplasia	Underdevelopment of the middle portion of the clavicle.	UMLS:C1844530	hp.json	Underdeveloped middle portion of the collarbone	http://purl.obolibrary.org/obo/HP_0006608		
PATO:0000956	biolink:NamedThing	sterile	A fertility quality inhering in a bearer by virtue of the bearer's being incapable of initiating, sustaining, or supporting reproduction.		hp.json		http://purl.obolibrary.org/obo/PATO_0000956		disposition_slim|value_slim
HP:0006603	biolink:PhenotypicFeature	Flared, irregular rib ends		UMLS:C1865833	hp.json	Flared, irregular rib ends	http://purl.obolibrary.org/obo/HP_0006603		
HP:0031614	biolink:PhenotypicFeature	Inferior retinal coloboma	A notch or cleft of the lower part of the retina.		hp.json		http://purl.obolibrary.org/obo/HP_0031614		
HP:0031615	biolink:PhenotypicFeature	Hypopyon	Presence of pus (appears as a white fluid) producing a fluid level in the inferior part of the anterior chamber.		hp.json		http://purl.obolibrary.org/obo/HP_0031615		
HP:0031616	biolink:PhenotypicFeature	Anterior chamber flare	An abnormal appearance of the beam of light traveling through the anterior chamber of the eye in a slit lamp examination. The flare is produced by an increased concentration of proteins in the aqueous humor in the anterior chamber.		hp.json		http://purl.obolibrary.org/obo/HP_0031616		
HP:0006606	biolink:PhenotypicFeature	Irregular chondrocostal junctions	Irregular surface of the normally relatively smooth border between the distal part of the ribs and the costal cartilages, which are bars of hyaline cartilage that connect the ribs to the sternum.	UMLS:C1861199	hp.json	Irregular costochondral margins	http://purl.obolibrary.org/obo/HP_0006606		
HP:0031610	biolink:PhenotypicFeature	Recurrent shoulder dislocation	Shoulder dislocation occurring repeated times.		hp.json	Multiple shoulder dislocation	http://purl.obolibrary.org/obo/HP_0031610		
HP:0031611	biolink:PhenotypicFeature	Sub-inner limiting membrane hemorrhage	A type of intraretinal hemorrhage that is located in the superficial retina between the inner limiting membrane and the retinal nerve fiber layer.		hp.json	Sub-inner limiting membrane haemorrhage|Sub-ILM haemorrhage|Sub-ILM hemorrhage	http://purl.obolibrary.org/obo/HP_0031611		
HP:0006600	biolink:PhenotypicFeature	Progressive calcification of costochondral cartilage		UMLS:C1968577	hp.json		http://purl.obolibrary.org/obo/HP_0006600		
HP:0031613	biolink:PhenotypicFeature	Inferior chorioretinal coloboma	Absence of a region of the retina, retinal pigment epithelium, and choroid at the lower part of the fundus.		hp.json		http://purl.obolibrary.org/obo/HP_0031613		
HP:0031618	biolink:PhenotypicFeature	Anterior chamber flare grade 1+	Faint anterior chamber flare.		hp.json		http://purl.obolibrary.org/obo/HP_0031618		
HP:0031619	biolink:PhenotypicFeature	Anterior chamber flare grade 2+	Moderate anterior chamber flare (iris and lens details clear).		hp.json		http://purl.obolibrary.org/obo/HP_0031619		
HP:0006659	biolink:PhenotypicFeature	Internally rotated shoulders		UMLS:C1862491	hp.json	Internally rotated shoulders	http://purl.obolibrary.org/obo/HP_0006659		
HP:0006655	biolink:PhenotypicFeature	Rib segmentation abnormalities		UMLS:C1968999	hp.json		http://purl.obolibrary.org/obo/HP_0006655		
HP:0006657	biolink:PhenotypicFeature	Hypoplasia of first ribs		UMLS:C1834386	hp.json	Small first rib|Hypoplastic first rib|Underdeveloped first rib|Hypoplastic first ribs	http://purl.obolibrary.org/obo/HP_0006657		
HP:0006650	biolink:PhenotypicFeature	Thickening of the lateral border of the scapula		UMLS:C1834383	hp.json	Thickening of the lateral border of the shoulder blade	http://purl.obolibrary.org/obo/HP_0006650		
HP:0004006	biolink:PhenotypicFeature	Round radial epiphyses		UMLS:C4025451	hp.json		http://purl.obolibrary.org/obo/HP_0004006		
HP:0004005	biolink:PhenotypicFeature	Large radial epiphyses		UMLS:C4025452	hp.json		http://purl.obolibrary.org/obo/HP_0004005		
HP:0004004	biolink:PhenotypicFeature	Irregular radial epiphyses		UMLS:C4025453	hp.json		http://purl.obolibrary.org/obo/HP_0004004		
HP:0004003	biolink:PhenotypicFeature	Medially flattened radial epiphyses		UMLS:C4025454	hp.json		http://purl.obolibrary.org/obo/HP_0004003		
HP:0006665	biolink:PhenotypicFeature	Coat hanger sign of ribs	An abnormal morphology of the ribs consisting of shorted, abnormally curved ribs. On posteroanterior chest radiography, the ribs show a curvature resembling that of a coat hanger (clothes hanger).	UMLS:C4025010	hp.json	Coat hanger sign of ribs	http://purl.obolibrary.org/obo/HP_0006665		
HP:0004009	biolink:PhenotypicFeature	Medially sloping radial epiphyses		UMLS:C4025448	hp.json		http://purl.obolibrary.org/obo/HP_0004009		
HP:0004008	biolink:PhenotypicFeature	Sloping radial epiphyses		UMLS:C4025449	hp.json		http://purl.obolibrary.org/obo/HP_0004008		
HP:0004007	biolink:PhenotypicFeature	Sclerotic radial epiphyses		UMLS:C4025450	hp.json		http://purl.obolibrary.org/obo/HP_0004007		
HP:0006668	biolink:PhenotypicFeature	Twelfth rib hypoplasia		UMLS:C1859361	hp.json	Small twelfth rib|Underdeveloped twelfth rib	http://purl.obolibrary.org/obo/HP_0006668		
HP:0004002	biolink:PhenotypicFeature	Flattened radial epiphyses		UMLS:C4025455	hp.json		http://purl.obolibrary.org/obo/HP_0004002		
HP:0004001	biolink:PhenotypicFeature	Medially deficient radial epiphyses		UMLS:C4025456	hp.json		http://purl.obolibrary.org/obo/HP_0004001		
HP:0004000	biolink:PhenotypicFeature	Cone-shaped distal radial epiphysis	The distal epiphysis (rounded portion of bone at the far end of the radius distal to the growth plate) has an abnormal cone-shaped appearance.	UMLS:C4025457	hp.json	Chevron-shaped distal radial epiphysis	http://purl.obolibrary.org/obo/HP_0004000		
HP:0006660	biolink:PhenotypicFeature	Aplastic clavicle	Absence of the clavicles as a developmental defect.	UMLS:C1857665	hp.json	Absent collarbone|Absent clavicles|Aplastic clavicles	http://purl.obolibrary.org/obo/HP_0006660		hposlim_core
HP:0006637	biolink:PhenotypicFeature	Sternal punctate calcifications		UMLS:C1859121	hp.json		http://purl.obolibrary.org/obo/HP_0006637		
GO:0032292	biolink:BiologicalProcess	peripheral nervous system axon ensheathment	The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.		hp.json	ensheathment of axons in peripheral nervous system	http://purl.obolibrary.org/obo/GO_0032292		
HP:0006638	biolink:PhenotypicFeature	Midclavicular aplasia	Developmental defect resulting in congenital absence of the middle portion of the clavicle.	UMLS:C1844529	hp.json	Missing middle part of collarbone	http://purl.obolibrary.org/obo/HP_0006638		
GO:0032291	biolink:BiologicalProcess	axon ensheathment in central nervous system	The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.		hp.json	ensheathment of axons in central nervous system	http://purl.obolibrary.org/obo/GO_0032291		
GO:0032290	biolink:BiologicalProcess	peripheral nervous system myelin formation	The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system.		hp.json	myelin formation in peripheral nervous system	http://purl.obolibrary.org/obo/GO_0032290		
HP:0006633	biolink:PhenotypicFeature	Glenoid fossa hypoplasia	Underdevelopment of the glenoid fossa, which is the cavity in the lateral part of the scapula which articulates with the head of the humerus.	UMLS:C1834384	hp.json	Hypoplastic glenoid fossa|Glenoid hypoplasia	http://purl.obolibrary.org/obo/HP_0006633		hposlim_core
HP:0006634	biolink:PhenotypicFeature	Osteosclerosis of ribs	Osteosclerosis of ribs (increased density related to increased bone mass).	UMLS:C4025013	hp.json	Increased bone density in ribs	http://purl.obolibrary.org/obo/HP_0006634		
HP:0006631	biolink:PhenotypicFeature	Hypoplastic distal segments of scapulae		UMLS:C4025014	hp.json	Small outermost segments of shoulder blade|Small distal segments of the shoulder blade|Underdeveloped outermost segments of shoulder blade	http://purl.obolibrary.org/obo/HP_0006631		
PATO:0000915	biolink:NamedThing	thickness	A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width.		hp.json		http://purl.obolibrary.org/obo/PATO_0000915		attribute_slim|scalar_slim
PATO:0000918	biolink:NamedThing	volume	A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies.		hp.json		http://purl.obolibrary.org/obo/PATO_0000918		scalar_slim|attribute_slim|mpath_slim
PATO:0000912	biolink:NamedThing	increased rate	A rate which is relatively high.		hp.json	fast rate|high rate	http://purl.obolibrary.org/obo/PATO_0000912		value_slim|mpath_slim
PATO:0000911	biolink:NamedThing	decreased rate	A rate which is relatively low.		hp.json	slow rate	http://purl.obolibrary.org/obo/PATO_0000911		mpath_slim|value_slim
HP:0006647	biolink:PhenotypicFeature	Congenital microthorax		UMLS:C4025011	hp.json		http://purl.obolibrary.org/obo/HP_0006647		
HP:0006649	biolink:PhenotypicFeature	Costochondral pain	Chest wall pain in the area of the costochondral junctions.	UMLS:C4021587	hp.json	Costochondral junction pain	http://purl.obolibrary.org/obo/HP_0006649		
HP:0006643	biolink:PhenotypicFeature	Fused sternal ossification centers		UMLS:C1859376	hp.json	Fused sternal ossification centres	http://purl.obolibrary.org/obo/HP_0006643		
HP:0006644	biolink:PhenotypicFeature	Thoracic dysplasia		UMLS:C1406921	hp.json		http://purl.obolibrary.org/obo/HP_0006644		
HP:0006645	biolink:PhenotypicFeature	Thin clavicles	Abnormally reduced diameter (cross section) of the clavicles.	UMLS:C0575535|SNOMEDCT_US:298764003	hp.json	Thin collarbone	http://purl.obolibrary.org/obo/HP_0006645		
HP:0006646	biolink:PhenotypicFeature	Costal cartilage calcification	Calcification of the costal cartilages, which are bars of hyaline cartilage found at the anterior ends of the ribs which serve to prolong the ribs forward and contribute to the elasticity of the walls of the thorax.	UMLS:C1855608	hp.json	Cartilaginous ossification of rib	http://purl.obolibrary.org/obo/HP_0006646		
HP:0006640	biolink:PhenotypicFeature	Multiple rib fractures	More than one fracture of the ribs.	UMLS:C0272567|SNOMEDCT_US:1261007	hp.json	Multiple rib fractures	http://purl.obolibrary.org/obo/HP_0006640		
HP:0006641	biolink:PhenotypicFeature	Prominent floating ribs		UMLS:C4025012	hp.json	Prominent floating ribs	http://purl.obolibrary.org/obo/HP_0006641		
GO:0032289	biolink:BiologicalProcess	central nervous system myelin formation	The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.		hp.json	myelin formation in central nervous system	http://purl.obolibrary.org/obo/GO_0032289		
HP:0006642	biolink:PhenotypicFeature	Large sternal ossification centers		UMLS:C1865241	hp.json	Large sternal ossification centres	http://purl.obolibrary.org/obo/HP_0006642		
GO:0032288	biolink:BiologicalProcess	myelin assembly	The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.		hp.json	myelin formation	http://purl.obolibrary.org/obo/GO_0032288		
GO:0032286	biolink:BiologicalProcess	central nervous system myelin maintenance	The process in which the structure and material content of mature central nervous system myelin is kept in a functional state.		hp.json	myelin maintenance in central nervous system	http://purl.obolibrary.org/obo/GO_0032286		
GO:0044262	biolink:BiologicalProcess	cellular carbohydrate metabolic process	The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.		hp.json	cellular carbohydrate metabolism|main pathways of carbohydrate metabolic process|main pathways of carbohydrate metabolism	http://purl.obolibrary.org/obo/GO_0044262		
GO:0010927	biolink:BiologicalProcess	cellular component assembly involved in morphogenesis	The cellular component assembly that is part of the initial shaping of the component during its developmental progression.		hp.json		http://purl.obolibrary.org/obo/GO_0010927		
GO:0044260	biolink:BiologicalProcess	cellular macromolecule metabolic process	The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.		hp.json	cellular macromolecule metabolism|cellular biopolymer metabolic process	http://purl.obolibrary.org/obo/GO_0044260		
UBERON:0002119	biolink:AnatomicalEntity	left ovary	An ovary that is part of a left side of organism [Automatically generated definition].	FMA:7214|UMLS:C0227874|EMAPA:37366|MA:0001704|NCIT:C32969|SCTID:280124008	hp.json		http://purl.obolibrary.org/obo/UBERON_0002119		
UBERON:0002118	biolink:AnatomicalEntity	right ovary	An ovary that is part of a right side of organism [Automatically generated definition].	FMA:7213|UMLS:C0227873|NCIT:C33487|EMAPA:37367|MA:0001705|SCTID:280123002	hp.json		http://purl.obolibrary.org/obo/UBERON_0002118		
GO:0010921	biolink:BiologicalProcess	regulation of phosphatase activity	Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.		hp.json		http://purl.obolibrary.org/obo/GO_0010921		
GO:0010922	biolink:BiologicalProcess	positive regulation of phosphatase activity	Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.		hp.json		http://purl.obolibrary.org/obo/GO_0010922		
GO:0044267	biolink:BiologicalProcess	cellular protein metabolic process	The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.		hp.json	cellular protein metabolism	http://purl.obolibrary.org/obo/GO_0044267		
GO:0010923	biolink:BiologicalProcess	negative regulation of phosphatase activity	Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.		hp.json		http://purl.obolibrary.org/obo/GO_0010923		
GO:0044264	biolink:NamedThing	cellular polysaccharide metabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0044264		
UBERON:0004781	biolink:AnatomicalEntity	gall bladder lamina propria	A lamina propria that is part of a gallbladder [Automatically generated definition].	UMLS:C1708175|MA:0001633|FMA:278594|EMAPA:35371|NCIT:C49228	hp.json	lamina propria of gallbladder|gall bladder lamina propria mucosa|biliary lamina propria|lamina propria of gall bladder|gallbladder lamina propria mucosa|gallbladder lamina propria|lamina propria mucosa of gall bladder|lamina propria mucosa of gallbladder	http://purl.obolibrary.org/obo/UBERON_0004781		
UBERON:0004782	biolink:AnatomicalEntity	gastrointestinal system serosa	A serous membrane that is part of a digestive system [Automatically generated definition].	EMAPA:37592|MA:0001522	hp.json	gastrointestinal system serous membrane|digestive system serosa|digestive system serous membrane|serosa of digestive system|serous membrane of gastrointestinal system|serous membrane of digestive system|serosa of gastrointestinal system	http://purl.obolibrary.org/obo/UBERON_0004782		
UBERON:0002120	biolink:AnatomicalEntity	pronephros	In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO].	ZFA:0000151|AAO:0011089|TAO:0000151|MESH:D060910|VHOG:0000037|EHDAA2:0001570|BTO:0001541|EMAPA:16579|EFO:0000927|NCIT:C34280|FMA:72170|UMLS:C0231048|EHDAA:1017|MAT:0000117|XAO:0002000|MIAA:0000117	hp.json	archinephron|pronephric kidney|pronephron|embryonic kidney	http://purl.obolibrary.org/obo/UBERON_0002120		efo_slim|uberon_slim|organ_slim
UBERON:0004780	biolink:AnatomicalEntity	gastrointestinal system lamina propria	A lamina propria that is part of a gastrointestinal system.	UMLS:C1708197|NCIT:C49299|MA:0001899	hp.json		http://purl.obolibrary.org/obo/UBERON_0004780		
UBERON:0004789	biolink:AnatomicalEntity	larynx mucous gland	A mucous gland that is part of a larynx [Automatically generated definition].	EMAPA:37631|MA:0001767	hp.json	mucous gland of larynx	http://purl.obolibrary.org/obo/UBERON_0004789		
GO:0071888	biolink:BiologicalProcess	macrophage apoptotic process	Any apoptotic process in a macrophage, a mononuclear phagocyte present in a variety of tissues.		hp.json	activation-induced cell death|AICD|macrophage apoptosis	http://purl.obolibrary.org/obo/GO_0071888		
UBERON:0002125	biolink:AnatomicalEntity	thymus lobule	A lobule that is part of a thymus. Divided into an outer cortex and inner medulla and separated from each other by connective tissue septa, but with the medullary tissue continuous from lobule to lobule.[ncit,modified].	FMA:72215|MA:0000770|NCIT:C33772|UMLS:C1522462	hp.json	lobule of thymus|thymus lobule|thymic lobule	http://purl.obolibrary.org/obo/UBERON_0002125		pheno_slim|human_reference_atlas
GO:0071887	biolink:BiologicalProcess	leukocyte apoptotic process	Any apoptotic process in a leukocyte, an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.		hp.json	leukocyte apoptosis	http://purl.obolibrary.org/obo/GO_0071887		
UBERON:0002128	biolink:AnatomicalEntity	superior olivary complex	A collection of brainstem nuclei that functions in multiple aspects of hearing and is an important component of the ascending and descending auditory pathways of the auditory system.	HBA:9177|UMLS:C0175427|VHOG:0001381|FMA:72247|DHBA:12462|BIRNLEX:1307|EV:0100263|Wikipedia:Superior_olivary_complex|MBA:398|BAMS:SOC|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=569|EMAPA:35840|MESH:D065832|MA:0001026	hp.json	nucleus olivaris superior|superior olivary nuclei|superior olivary nucleus (Barr & Kiernan)|superior olivary nucleus|regio olivaris superioris|superior olive	http://purl.obolibrary.org/obo/UBERON_0002128		uberon_slim
UBERON:0004785	biolink:AnatomicalEntity	respiratory system mucosa	The mucous membrane lining the respiratory tract.	EMAPA:37577|BTO:0000973|MA:0001827|FMA:302092|GAID:304|MESH:D020545|EMAPA:18334	hp.json	apparatus respiratorius mucosa|respiratory system mucous membrane|mucosa of organ of respiratory system|mucous membrane of apparatus respiratorius|apparatus respiratorius mucosa of organ|mucosa of apparatus respiratorius|mucosa of respiratory system|mucous membrane of respiratory system|respiratory tract mucosa|mucosa of organ of apparatus respiratorius|respiratory mucosa|apparatus respiratorius mucous membrane|laryngeal mucous membrane|respiratory system mucosa of organ	http://purl.obolibrary.org/obo/UBERON_0004785		pheno_slim
UBERON:0002122	biolink:AnatomicalEntity	capsule of thymus	The fibrous connective tissue surrounding the thymus.	NCIT:C33770|UMLS:C0229945|EMAPA:19306|MA:0000766|FMA:72204	hp.json	thymus capsule|thymic capsule	http://purl.obolibrary.org/obo/UBERON_0002122		pheno_slim|human_reference_atlas
UBERON:0004786	biolink:AnatomicalEntity	gastrointestinal system mucosa	A mucosa that is part of a gastrointestinal system.	BTO:0005568|MA:0001521|SCTID:410433007|BTO:0000546|EMAPA:36591	hp.json	gut mucosa|mucosa of gut|digestive tract mucosa|gut mucuous membrane|mucosa of gut|digestive tract mucosa|gut mucuous membrane	http://purl.obolibrary.org/obo/UBERON_0004786		
UBERON:0002124	biolink:AnatomicalEntity	medulla of thymus	Medullary portion of thymus. The reticulum is coarser than in the cortex, the lymphoid cells are relatively fewer in number, and there are found peculiar nest-like bodies, the concentric corpuscles of Hassall. These concentric corpuscles are composed of a central mass, consisting of one or more granular cells, and of a capsule formed of epithelioid cells. They are the remains of the epithelial tubes, which grow out from the third branchial pouches of the embryo to form the thymus. Each follicle is surrounded by a vascular plexus, from which vessels pass into the interior, and radiate from the periphery toward the center, forming a second zone just within the margin of the medullary portion. In the center of the medullary portion there are very few vessels, and they are of minute size.	UMLS:C0229949|EMAPA:19305|EFO:0001969|BTO:0004560|FMA:72206|NCIT:C33775|MA:0000771	hp.json	medulla of thymus gland|thymus gland medulla|thymus medulla	http://purl.obolibrary.org/obo/UBERON_0002124		pheno_slim|human_reference_atlas|efo_slim
UBERON:0004783	biolink:AnatomicalEntity	gall bladder serosa	A serous membrane that is part of a gallbladder [Automatically generated definition].	FMA:14659|MA:0001634|EMAPA:35372	hp.json	serous coat of gallbladder|biliary serosa|serosa of gallbladder|serosa of gall bladder|gall bladder serous membrane|gallbladder serosa|tunica serosa (vesica biliaris)|gallbladder serous membrane|serous membrane of gall bladder|serous membrane of gallbladder|tunica serosa vesicae biliaris	http://purl.obolibrary.org/obo/UBERON_0004783		
UBERON:0002123	biolink:AnatomicalEntity	cortex of thymus	The outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes.	UMLS:C0229948|EMAPA:35863|MA:0000767|FMA:72205|BTO:0002934|NCIT:C33774	hp.json	thymus cortex|thymic cortex	http://purl.obolibrary.org/obo/UBERON_0002123		pheno_slim|human_reference_atlas
UBERON:0004784	biolink:AnatomicalEntity	heart ventricle wall	An anatomical wall that is part of a cardiac ventricle [Automatically generated definition].	MA:0002791|FMA:13884|NCIT:C119295	hp.json	wall of cardiac ventricle|anatomical wall of heart ventricle|lower chamber of heart anatomical wall|ventricle of heart anatomical wall|wall of heart ventricle|cardiac ventricle anatomical wall|wall of ventricle|wall of lower chamber of heart|wall of ventricle of heart|cardiac ventricle wall|anatomical wall of lower chamber of heart|heart ventricle anatomical wall|anatomical wall of ventricle of heart|ventricle of heart wall|lower chamber of heart wall|anatomical wall of cardiac ventricle|ventricular wall	http://purl.obolibrary.org/obo/UBERON_0004784		pheno_slim
GO:0044272	biolink:BiologicalProcess	sulfur compound biosynthetic process	The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.		hp.json	sulfur compound biosynthesis|sulfur compound anabolism|sulfur biosynthesis|sulfur biosynthetic process|sulfur compound synthesis|sulfur compound formation	http://purl.obolibrary.org/obo/GO_0044272		
GO:0010938	biolink:BiologicalProcess	cytoplasmic microtubule depolymerization	The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule.		hp.json		http://purl.obolibrary.org/obo/GO_0010938		
GO:0044271	biolink:BiologicalProcess	cellular nitrogen compound biosynthetic process	The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.		hp.json	nitrogen compound biosynthesis|nitrogen compound anabolism|nitrogen compound synthesis|nitrogen compound formation	http://purl.obolibrary.org/obo/GO_0044271		
UBERON:0002108	biolink:AnatomicalEntity	small intestine	Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong].	GAID:313|VHOG:0000055|ZFA:0001323|FMA:7200|TAO:0001323|XAO:0000130|EMAPA:32834|MAT:0000047|EFO:0000841|AAO:0010397|NCIT:C12386|OpenCyc:Mx4rvVjlIJwpEbGdrcN5Y29ycA|MIAA:0000047|BTO:0000651|CALOHA:TS-0942|MESH:D007421|UMLS:C0021852|galen:SmallIntestine|MA:0000337|EV:0100072	hp.json	small intestine|mid intestine|anterior intestine|intestinum tenue|small bowel|intestinum tenue	http://purl.obolibrary.org/obo/UBERON_0002108		vertebrate_core|major_organ|organ_slim|pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0002107	biolink:AnatomicalEntity	liver	An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO].	MESH:D008099|EHDAA2:0000997|BTO:0000759|GAID:288|ZFA:0000123|XAO:0000133|EFO:0000887|TAO:0000123|UMLS:C0023884|FMA:7197|galen:Liver|AAO:0010111|EV:0100089|OpenCyc:Mx4rvVimppwpEbGdrcN5Y29ycA|EHDAA:2197|EMAPA:16846|MAT:0000097|VHOG:0000257|NCIT:C12392|CALOHA:TS-0564|MIAA:0000097|MA:0000358	hp.json	jecur|iecur	http://purl.obolibrary.org/obo/UBERON_0002107		vertebrate_core|major_organ|organ_slim|pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0004769	biolink:AnatomicalEntity	diaphysis	Subdivision of long bone which forms the part of the bone between the two epiphyses, excluding the metaphyses[FMA,modified].	GAID:189|EMAPA:35504|FMA:24013|MESH:D018483	hp.json	long bone diaphysis|body of long bone|shaft of long bone	http://purl.obolibrary.org/obo/UBERON_0004769		pheno_slim|uberon_slim
UBERON:0002109	biolink:AnatomicalEntity	pair of nares	Pair of nostrils.	OpenCyc:Mx4rvViCLpwpEbGdrcN5Y29ycA|FMA:72005	hp.json	nostrils|nares set|nares|set of nares|pair of nostrils	http://purl.obolibrary.org/obo/UBERON_0002109		uberon_slim
GO:0010936	biolink:BiologicalProcess	negative regulation of macrophage cytokine production	Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.		hp.json		http://purl.obolibrary.org/obo/GO_0010936		
GO:0010937	biolink:BiologicalProcess	regulation of cytoplasmic microtubule depolymerization	Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization.		hp.json		http://purl.obolibrary.org/obo/GO_0010937		
GO:0010934	biolink:BiologicalProcess	macrophage cytokine production	The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.		hp.json		http://purl.obolibrary.org/obo/GO_0010934		gocheck_do_not_annotate
GO:0010935	biolink:BiologicalProcess	regulation of macrophage cytokine production	Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.		hp.json		http://purl.obolibrary.org/obo/GO_0010935		
GO:0044275	biolink:NamedThing	cellular carbohydrate catabolic process			hp.json		http://purl.obolibrary.org/obo/GO_0044275		
UBERON:0004770	biolink:AnatomicalEntity	articular system	Anatomical system that consists of all the joints of the body.	FMA:23878|SCTID:361827000|MA:0003007|VSAO:0000181|EMAPA:35150	hp.json	set of all joints of body|set of joints of body|joint system|set of all joints	http://purl.obolibrary.org/obo/UBERON_0004770		
UBERON:0004771	biolink:AnatomicalEntity	posterior nasal aperture	Opening/conduit between the nasal cavity and the nasopharynx[AAO] The choanae are separated by the vomer[WP].	EHDAA:7842|EMAPA:17849|EHDAA2:0000242|VHOG:0000545|FMA:53143|AAO:0000093|XAO:0000277|MA:0001323	hp.json	nasopharyngeal naris|choana|posterior nasal apperture|internal naris|posterior naris|posterior choana|choanae	http://purl.obolibrary.org/obo/UBERON_0004771		pheno_slim
GO:0140053	biolink:BiologicalProcess	mitochondrial gene expression	The process in which a mitochondrial gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.		hp.json		http://purl.obolibrary.org/obo/GO_0140053		goslim_generic|goslim_pombe
GO:0140056	biolink:BiologicalProcess	organelle localization by membrane tethering	The process by which an organelle membrane interacts with another membrane via molecular tethers that physically bridge the two membranes and attach them to each other.		hp.json		http://purl.obolibrary.org/obo/GO_0140056		goslim_pombe
UBERON:0002115	biolink:AnatomicalEntity	jejunum	The portion of the small intestine that extends from the duodenum to the ileum.	OpenCyc:Mx4rwATkPJwpEbGdrcN5Y29ycA|BTO:0000657|MA:0000340|NCIT:C12388|MAT:0000045|EFO:0001333|GAID:318|EV:0100074|MIAA:0000045|FMA:7207|UMLS:C0022378|galen:Jejunum|MESH:D007583|CALOHA:TS-0496|EMAPA:18666|VHOG:0000053	hp.json	intestinum jejunum|mid-intestine|middle intestine	http://purl.obolibrary.org/obo/UBERON_0002115		pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0004778	biolink:AnatomicalEntity	larynx submucosa	A submucosa that is part of a larynx [Automatically generated definition].	MA:0002728|SCTID:361941005|FMA:321584|EMAPA:35474	hp.json	laryngeal submucosa|submucosa of larynx	http://purl.obolibrary.org/obo/UBERON_0004778		
UBERON:0002114	biolink:AnatomicalEntity	duodenum	The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one).	AAO:0010402|OpenCyc:Mx4rv4LJDpwpEbGdrcN5Y29ycA|GAID:284|EFO:0000851|MAT:0000044|galen:Duodenum|BTO:0000365|NCIT:C12263|MESH:D004386|CALOHA:TS-0214|MIAA:0000044|EV:0100073|MA:0000338|UMLS:C0013303|XAO:0000236|FMA:7206|EMAPA:18852|VHOG:0000052	hp.json	proximal intestine|upper intestine	http://purl.obolibrary.org/obo/UBERON_0002114		pheno_slim|human_reference_atlas|efo_slim|uberon_slim|vertebrate_core
UBERON:0004779	biolink:AnatomicalEntity	respiratory system lamina propria	A lamina propria that is part of a respiratory system [Automatically generated definition].	EMAPA:37576|MA:0001821	hp.json	respiratory system lamina propria mucosa|lamina propria mucosa of apparatus respiratorius|lamina propria of respiratory system|lamina propria of apparatus respiratorius|lamina propria mucosa of respiratory system|apparatus respiratorius lamina propria mucosa|apparatus respiratorius lamina propria	http://purl.obolibrary.org/obo/UBERON_0004779		
UBERON:0002116	biolink:AnatomicalEntity	ileum	The portion of the small intestine that extends from the jejunum to the colon.	AAO:0010403|CALOHA:TS-0472|galen:Ileum|OpenCyc:Mx4rvdcLHZwpEbGdrcN5Y29ycA|MESH:D007082|VHOG:0000647|UMLS:C0020885|NCIT:C12387|BTO:0000620|EFO:0001334|EMAPA:32764|EV:0100075|FMA:7208|MA:0000339|XAO:0000237|MAT:0000282|GAID:315|MIAA:0000282	hp.json	intestinum ileum|posterior intestine|distal intestine|lower intestine	http://purl.obolibrary.org/obo/UBERON_0002116		pheno_slim|human_reference_atlas|efo_slim|uberon_slim
GO:0071874	biolink:BiologicalProcess	cellular response to norepinephrine stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.		hp.json	cellular response to noradrenaline stimulus	http://purl.obolibrary.org/obo/GO_0071874		
UBERON:0004777	biolink:AnatomicalEntity	respiratory system submucosa	A submucosa that is part of a respiratory system [Automatically generated definition].	EMAPA:37578|MA:0001822	hp.json	submucosa of apparatus respiratorius|submucosa of respiratory system|apparatus respiratorius submucosa	http://purl.obolibrary.org/obo/UBERON_0004777		
UBERON:0002111	biolink:AnatomicalEntity	artery smooth muscle tissue	A portion of smooth muscle tissue that is part of an artery [Automatically generated definition].	MA:0000708|FMA:72024|BTO:0000087|NCIT:C49195|CALOHA:TS-1198|UMLS:C1706851|EMAPA:36285	hp.json	artery smooth muscle|artery smooth muscle tissue|arterial smooth muscle|arterial smooth muscle cell|smooth muscle of artery	http://purl.obolibrary.org/obo/UBERON_0002111		
GO:0071873	biolink:BiologicalProcess	response to norepinephrine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a norepinephrine stimulus. Norepinephrine is a catecholamine that has the formula C8H11NO3; it acts as a hormone, and as a neurotransmitter in most of the sympathetic nervous system.		hp.json	response to noradrenaline stimulus|response to norepinephrine stimulus	http://purl.obolibrary.org/obo/GO_0071873		
UBERON:0004774	biolink:AnatomicalEntity	inferior eyelid tarsus	An eyelid tarsus that is part of a lower eyelid [Automatically generated definition].	EMAPA:37606|MA:0001257|FMA:59088	hp.json	tarsus of lower eyelid|inferior tarsal plate|inferior tarsus|tarsal plate of lower eyelid|tarsus inferior|inferior tarsus of eyelid	http://purl.obolibrary.org/obo/UBERON_0004774		
UBERON:0002110	biolink:AnatomicalEntity	gall bladder	An organ that aids digestion and stores bile produced by the liver[WP].	EFO:0000853|AAO:0010114|NCIT:C12377|UMLS:C0016976|ZFA:0000208|TAO:0000208|MAT:0000072|VHOG:0000221|BTO:0000493|OpenCyc:Mx4rvVkGr5wpEbGdrcN5Y29ycA|XAO:0000135|EMAPA:17202|MA:0000356|MIAA:0000072|EHDAA2:0000699|FMA:7202|EV:0100090|MESH:D005704|EHDAA:8062|CALOHA:TS-0394|galen:Gallbladder	hp.json	vesica fellea|gallbladder|gall bladder|vesica biliaris	http://purl.obolibrary.org/obo/UBERON_0002110		organ_slim|pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0002113	biolink:AnatomicalEntity	kidney	A paired organ of the urinary tract which has the production of urine as its primary function.	XAO:0003267|MIAA:0000119|galen:Kidney|OpenCyc:Mx4rvVjlYpwpEbGdrcN5Y29ycA|EMAPA:17373|MESH:D007668|EFO:0000929|EV:0100096|BTO:0000671|AAO:0000250|CALOHA:TS-0510|UMLS:C0022646|GAID:423|MAT:0000119|MA:0000368|NCIT:C12415|FMA:7203	hp.json	reniculate kidney	http://purl.obolibrary.org/obo/UBERON_0002113		organ_slim|pheno_slim|efo_slim|human_reference_atlas|uberon_slim|major_organ|vertebrate_core
UBERON:0004772	biolink:AnatomicalEntity	eyelid tarsus	The tarsi (tarsal plates) are two comparatively thick, elongated plates of dense connective tissue, about 2.5 cm. in length; one is found in each eyelid, and contributes to its form and support. They directly abut the lid margins.	MA:0000270|NCIT:C33736|UMLS:C0459586|FMA:59086	hp.json	tarsal plate|tarsal plate of eyelid|eyelid tarsi|tarsus palpebralis|tarsi	http://purl.obolibrary.org/obo/UBERON_0004772		organ_slim
UBERON:0002112	biolink:AnatomicalEntity	smooth muscle of esophagus	A portion of smooth muscle tissue that is part of a esophagus [Automatically generated definition].	MA:0001573|FMA:72025|EMAPA:35323	hp.json	involuntary muscle of gullet|oesophagus smooth muscle|smooth muscle of oesophagus|smooth muscle of gullet|esophagus involuntary muscle|smooth muscle tissue of oesophagus|gullet involuntary muscle|oesophagus involuntary muscle|smooth muscle tissue of gullet|gullet smooth muscle tissue|esophagus smooth muscle tissue|oesophagus non-striated muscle|gullet non-striated muscle|esophagus non-striated muscle|oesophagus smooth muscle tissue|esophageal smooth muscle|smooth muscle tissue of esophagus|gullet smooth muscle|esophagus smooth muscle|non-striated muscle of oesophagus|involuntary muscle of esophagus|non-striated muscle of gullet|non-striated muscle of esophagus|involuntary muscle of oesophagus	http://purl.obolibrary.org/obo/UBERON_0002112		pheno_slim
GO:0071870	biolink:BiologicalProcess	cellular response to catecholamine stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a catecholamine stimulus. A catecholamine is any of a group of biogenic amines that includes 4-(2-aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution.		hp.json		http://purl.obolibrary.org/obo/GO_0071870		
UBERON:0004773	biolink:AnatomicalEntity	superior eyelid tarsus	An eyelid tarsus that is part of a upper eyelid [Automatically generated definition].	MA:0001260|EMAPA:37607|FMA:59087	hp.json	superior tarsus of eyelid|tarsus of upper eyelid|superior tarsal plate|tarsal plate of upper eyelid|superior tarsus|tarsus superior	http://purl.obolibrary.org/obo/UBERON_0004773		
GO:0010907	biolink:BiologicalProcess	positive regulation of glucose metabolic process	Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.		hp.json	positive regulation of glucose metabolism	http://purl.obolibrary.org/obo/GO_0010907		
GO:0044283	biolink:BiologicalProcess	small molecule biosynthetic process	The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.		hp.json	small molecule biosynthesis	http://purl.obolibrary.org/obo/GO_0044283		prokaryote_subset
GO:0044281	biolink:BiologicalProcess	small molecule metabolic process	The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.		hp.json	small molecule metabolism	http://purl.obolibrary.org/obo/GO_0044281		goslim_flybase_ribbon|goslim_metagenomics|goslim_chembl
GO:0010906	biolink:BiologicalProcess	regulation of glucose metabolic process	Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.		hp.json	regulation of glucose metabolism	http://purl.obolibrary.org/obo/GO_0010906		
GO:0044282	biolink:BiologicalProcess	small molecule catabolic process	The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.		hp.json	small molecule catabolism	http://purl.obolibrary.org/obo/GO_0044282		
CHEBI:35516	biolink:ChemicalSubstance	cholestane		CAS:14982-53-7|Beilstein:5334741|LIPID_MAPS_instance:LMST01010000|CAS:14982-53-7|Wikipedia:Cholestane	hp.json	cholestane	http://purl.obolibrary.org/obo/CHEBI_35516		3_STAR
CHEBI:35519	biolink:ChemicalSubstance	cholane			hp.json	cholane	http://purl.obolibrary.org/obo/CHEBI_35519		3_STAR
UBERON:0004760	biolink:AnatomicalEntity	gland of anal canal	A gland that is part of an anal canal [Automatically generated definition].	NCIT:C32068|SCTID:245448005|FMA:15724|FMA:15720|EMAPA:27543|UMLS:C0162322|Wikipedia:Anal_gland|EMAPA:27233|EMAPA:27221	hp.json	rectal gland|anal sac|anal gland|gland of anus|anal sac|gland of anal canal	http://purl.obolibrary.org/obo/UBERON_0004760		organ_slim|human_reference_atlas
UBERON:0002104	biolink:AnatomicalEntity	visual system	The sensory system subserving the sense of vision.	http://uri.neuinfo.org/nif/nifstd/FMAID_7191|NCIT:C12888|TAO:0001127|MA:0002444|SCTID:281831001|Wikipedia:Visual_system|AAO:0000632|XAO:0003198|OpenCyc:Mx4rvViCtpwpEbGdrcN5Y29ycA|UMLS:C0587900|FMA:7191|EMAPA:36003|ZFA:0001127|BILA:0000140	hp.json	visual organ system|photosensory system	http://purl.obolibrary.org/obo/UBERON_0002104		vertebrate_core|pheno_slim|uberon_slim
UBERON:0004767	biolink:AnatomicalEntity	vomerine tooth	A tooth that is on the vomer.	AAO:0000635|TAO:0001631	hp.json		http://purl.obolibrary.org/obo/UBERON_0004767		
UBERON:0002103	biolink:AnatomicalEntity	hindlimb	A (free) limb that is connected to a pelvic girdle region. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pelvic girdle and its parts.	MA:0000026|EHDAA:6094|VSAO:0000150|UMLS:C0023216|NCIT:C12742|EV:0100015|MESH:D006614|UMLS:C1522391|GAID:38|FMA:24879|VHOG:0000337|XAO:0003031|EFO:0000883|EHDAA2:0001033|BTO:0002345|GAID:1221|MAT:0000395|galen:LowerExtremity|CALOHA:TS-2215|MIAA:0000395|EMAPA:17458|NCIT:C77625|AAO:0000219	hp.json	membrum inferius|hind-limb|inferior member|hind limb|pelvic appendage|hindlimb|free part of lower limb|membrum inferius|free lower limb|lower extremity|lower limb	http://purl.obolibrary.org/obo/UBERON_0002103		pheno_slim|efo_slim|uberon_slim
UBERON:0004768	biolink:AnatomicalEntity	bone of lower jaw	Any bone that is part of the lower jaw skeleton. This includes (when present): the dentary/mandible, the articular, the splenial, the suprangular.		hp.json	lower jaw bone	http://purl.obolibrary.org/obo/UBERON_0004768		grouping_class
UBERON:0002106	biolink:AnatomicalEntity	spleen	The organ that functions to filter blood and to store red corpuscles and platelets.	EFO:0000869|MIAA:0000085|TAO:0000436|VHOG:0000120|galen:Spleen|OpenCyc:Mx4rvVjgw5wpEbGdrcN5Y29ycA|BTO:0001281|NCIT:C12432|CALOHA:TS-0956|MA:0000141|GAID:1289|FMA:7196|EV:0100055|MESH:D013154|XAO:0000328|AAO:0010395|UMLS:C0037993|MAT:0000085|ZFA:0000436|EMAPA:18767	hp.json	lien	http://purl.obolibrary.org/obo/UBERON_0002106		vertebrate_core|organ_slim|pheno_slim|human_reference_atlas|efo_slim|uberon_slim
UBERON:0004765	biolink:AnatomicalEntity	skeletal element	Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.	AAO:0011129|galen:SkeletalStructure|XAO:0004012|VSAO:0000128|TAO:0001890|ZFA:0005494	hp.json		http://purl.obolibrary.org/obo/UBERON_0004765		organ_slim|uberon_slim
UBERON:0002105	biolink:AnatomicalEntity	vestibulo-auditory system	Sensory system responsible for the perception of spatial orientation and auditory stimuli.	EMAPA:36002|TAO:0001138|EMAPA:37985|AAO:0000631|XAO:0003195|FMA:78500|ZFA:0001138	hp.json	vestibuloauditory system|auditory system|vestibuloauditory system|auditory/vestibular system|auditory organ system	http://purl.obolibrary.org/obo/UBERON_0002105		vertebrate_core|functional_classification|pheno_slim|uberon_slim
GO:0009913	biolink:BiologicalProcess	epidermal cell differentiation	The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.		hp.json	hypodermal cell differentiation	http://purl.obolibrary.org/obo/GO_0009913		
UBERON:0004766	biolink:AnatomicalEntity	cranial bone	A bone that is part of a cranium.	SCTID:181792001	hp.json	cranium bone	http://purl.obolibrary.org/obo/UBERON_0004766		
UBERON:0002100	biolink:AnatomicalEntity	trunk	Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.	EMAPA:31857|TAO:0001115|XAO:0003025|XAO:0000054|BILA:0000116|CALOHA:TS-1071|OpenCyc:Mx4rvVkJjpwpEbGdrcN5Y29ycA|MAT:0000296|galen:Trunk|NCIT:C33816|FMA:7181|SCTID:262225004|MIAA:0000296|BTO:0001493|Wikipedia:Torso|ZFA:0001115|UMLS:C0460005|AAO:0010339|MA:0000004|EFO:0000966	hp.json	Rumpf|trunk region|torso|thoracolumbar region	http://purl.obolibrary.org/obo/UBERON_0002100		pheno_slim|efo_slim|uberon_slim|vertebrate_core
GO:0009914	biolink:BiologicalProcess	hormone transport	The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.		hp.json		http://purl.obolibrary.org/obo/GO_0009914		goslim_pir
UBERON:0004763	biolink:AnatomicalEntity	endochondral bone tissue	Replacement bone tissue that forms within cartilage[VSAO, modified].	EMAPA:35304|MA:0002836	hp.json		http://purl.obolibrary.org/obo/UBERON_0004763		uberon_slim|vertebrate_core
UBERON:0004764	biolink:AnatomicalEntity	intramembranous bone tissue	Bone tissue that forms directly within mesenchyme, and does not replace other tissues[TAO]. Intramembranous ossification is the formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified[GO]. Intramembranous ossification is the way flat bones and the shell of a turtle are formed[GO]. Unlike endochondral ossification, cartilage is not present during intramembranous ossification[WP].	Wikipedia:Intramembranous_ossification|MA:0002837	hp.json		http://purl.obolibrary.org/obo/UBERON_0004764		
UBERON:0002102	biolink:AnatomicalEntity	forelimb	A (free) limb that is connected to a pectoral girdle. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pectoral girdle and its parts.	EHDAA:6208|MA:0000025|AAO:0000205|GAID:1215|EV:0100014|VHOG:0000338|FMA:24878|EFO:0000882|EHDAA2:0002133|VSAO:0000148|XAO:0003030|NCIT:C12671|UMLS:C1140618|MESH:D005552|MAT:0000394|galen:UpperExtremity|CALOHA:TS-2214|GAID:51|BTO:0001729|MIAA:0000394|EMAPA:17412	hp.json	forelimb|pectoral limb|foreleg|free part of upper limb|pectoral flipper|superior member|anteriormost limb|upper extremity|fore limb|free upper limb|membrum superius|upper limb	http://purl.obolibrary.org/obo/UBERON_0002102		pheno_slim|efo_slim|uberon_slim
UBERON:0004761	biolink:AnatomicalEntity	cartilaginous neurocranium	The primitive cartilagionous skeletal structure of the fetal skull that grows to envelop the rapidly growing embyonic brain. In humans, the chondrocranium begins forming at 28 days from mesenchymal condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull in most higher vertebrates, some components do persist into adulthood.[1] In Cartilagious fishes and Agnathans, the chondrocranium persist throughout life.[2] Embryologically, the chondrocranium represent the basal cranial structure, and lay the base for the formation of the endocranium in higher vertebrates[WP].	Wikipedia:Chondrocranium|NCIT:C34121|FMA:76621|UMLS:C1516496|AAO:0010153|EHDAA:6031|AAO:0000094|SCTID:155540009|XAO:0003059	hp.json	embryonic chondocranium|chondocranium|cartilaginous skull|cartilaginous chondocranium|neurocranium|cartiligionous skeletal structure of skull|chondocranium	http://purl.obolibrary.org/obo/UBERON_0004761		
UBERON:0002101	biolink:AnatomicalEntity	limb	A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts.	AEO:0000172|MAT:0000090|AAO:0010336|EHDAA:1697|EFO:0000876|MIAA:0000090|GAID:36|galen:Extremity|VHOG:0000336|OpenCyc:Mx4rvn1uSZwpEbGdrcN5Y29ycA|FMA:24875|EMAPA:16405|NCIT:C12429|MA:0000007|VSAO:0000121|CALOHA:TS-0552|EHDAA2:0003172|EHDAA:8273|UMLS:C0015385|XAO:0003027	hp.json	pentadactyl limb|flipper|extremities|free limb|extremity|limb sensu Vertebrata|tetrapod limb	http://purl.obolibrary.org/obo/UBERON_0002101		pheno_slim|efo_slim|uberon_slim
GO:0010911	biolink:BiologicalProcess	regulation of isomerase activity	Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.		hp.json		http://purl.obolibrary.org/obo/GO_0010911		
GO:0010912	biolink:BiologicalProcess	positive regulation of isomerase activity	Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.		hp.json		http://purl.obolibrary.org/obo/GO_0010912		
GO:0044297	biolink:CellularComponent	cell body	The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.	Wikipedia:Cell_body|FMA:67301|FBbt:00005107	hp.json	cell soma	http://purl.obolibrary.org/obo/GO_0044297		
CHEBI:35522	biolink:ChemicalSubstance	beta-adrenergic agonist	An agent that selectively binds to and activates beta-adrenergic receptors.		hp.json	beta-adrenergic receptor agonist|beta-adrenergic agonists|beta-adrenoceptor agonists	http://purl.obolibrary.org/obo/CHEBI_35522		3_STAR
CHEBI:35524	biolink:ChemicalSubstance	sympathomimetic agent	A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.		hp.json	sympathomimetic|sympathomimetics	http://purl.obolibrary.org/obo/CHEBI_35524		3_STAR
CHEBI:35526	biolink:ChemicalSubstance	hypoglycemic agent	A drug which lowers the blood glucose level.		hp.json	antihyperglycemic|antihyperglycemics|antihyperglycemic drug|hypoglycemic drugs|antihyperglycemic agents|antidiabetic|antihyperglycemic agent|hypoglycemic drug|antihyperglycemic drugs|hypoglycemic agents	http://purl.obolibrary.org/obo/CHEBI_35526		3_STAR
UBERON:0004756	biolink:AnatomicalEntity	dermal skeletal element	Dermis-derived entity that is made of skeletal tissue.		hp.json	dermal element	http://purl.obolibrary.org/obo/UBERON_0004756		
UBERON:0004755	biolink:AnatomicalEntity	skeletal tissue	A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].	XAO:0004038|EMAPA:37744|MA:0003047|VSAO:0000015|SCTID:309311006|ZFA:0005619	hp.json		http://purl.obolibrary.org/obo/UBERON_0004755		
UBERON:0004753	biolink:AnatomicalEntity	scapulocoracoid	Skeletal element that consists of the scapula and the coracoid[VSAO, modified].	VSAO:0005002|ZFA:0001455|TAO:0001455|AAO:0000781	hp.json	scapulo-coracoid cartilage|scapulocoracoideum|scapulocoracoid cartilage|coraco-scapular cartilage	http://purl.obolibrary.org/obo/UBERON_0004753		
GO:0140029	biolink:BiologicalProcess	exocytic process	The cellular processes that contribute to exocytosis.		hp.json		http://purl.obolibrary.org/obo/GO_0140029		gocheck_do_not_annotate
UBERON:0002169	biolink:AnatomicalEntity	alveolar sac	The small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters.	MA:0000418|FMA:7317|UMLS:C0225691|OpenCyc:Mx4rwCvh75wpEbGdrcN5Y29ycA|BTO:0000061|NCIT:C32057|EMAPA:35119	hp.json	pulmonary alveolar sac|sacculus alveolaris|air sac	http://purl.obolibrary.org/obo/UBERON_0002169		uberon_slim|pheno_slim
UBERON:0002166	biolink:AnatomicalEntity	endocardium of atrium	Endocardium that is part of the atrium.	ZFA:0001614|SCTID:192001005|VHOG:0000606|MA:0000077|TAO:0002169|EMAPA:32745|FMA:7284	hp.json	cardiac atrium endocardium|atrium endocardial tissue|endocardium of heart atrium|atrial endocardium|Cardiac atria endocardium|atrium endocardium|endocardium of cardiac atrium|endocardium of Cardiac atria|heart atrium endocardium|atrium of heart endocardium|endocardium of atrium of heart	http://purl.obolibrary.org/obo/UBERON_0002166		vertebrate_core|pheno_slim
UBERON:0002165	biolink:AnatomicalEntity	endocardium	The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers[GO].	FMA:7280|AAO:0010408|EHDAA2:0004153|OpenCyc:Mx4rsWA75K1cEduAAADggVaqvw|UMLS:C0014124|galen:Endocardium|XAO:0000066|VHOG:0000084|EFO:0000821|ZFA:0001320|GAID:550|MAT:0000455|CALOHA:TS-2075|Wikipedia:Endocardium|MESH:D004699|NCIT:C13004|MA:0000076|TAO:0001320|SCTID:362013006|EMAPA:32686|EV:0100021|BTO:0000387|EMAPA:17868	hp.json	heart endocardium|endocardial tissue|heart endocardial tissue|endocardial lining	http://purl.obolibrary.org/obo/UBERON_0002165		uberon_slim|vertebrate_core|pheno_slim|efo_slim
UBERON:0002168	biolink:AnatomicalEntity	left lung	Lung which consists of the left upper lobe and left lower lobe.[FMA].	NCIT:C32967|UMLS:C0225730|MA:0000425|EHDAA:4947|OpenCyc:Mx8Ngh4rvgIFoJwpEbGdrcN5Y29ycB4rvVjKy5wpEbGdrcN5Y29ycA|EHDAA2:0000943|EMAPA:17653|VHOG:0000618|FMA:7310|Wikipedia:Left_lung|SCTID:361982005	hp.json		http://purl.obolibrary.org/obo/UBERON_0002168		human_reference_atlas|uberon_slim|pheno_slim
UBERON:0002167	biolink:AnatomicalEntity	right lung	Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA].	VHOG:0000301|MA:0000426|EHDAA:4969|EMAPA:17661|EHDAA2:0001730|SCTID:361967000|Wikipedia:Right_lung|UMLS:C0225706|NCIT:C33483|OpenCyc:Mx8Ngh4rvgHsHZwpEbGdrcN5Y29ycB4rvVjKy5wpEbGdrcN5Y29ycA|FMA:7309	hp.json		http://purl.obolibrary.org/obo/UBERON_0002167		uberon_slim|pheno_slim|human_reference_atlas
CHEBI:35508	biolink:ChemicalSubstance	steroid fundamental parent			hp.json	steroid fundamental parents	http://purl.obolibrary.org/obo/CHEBI_35508		3_STAR
CHEBI:35507	biolink:ChemicalSubstance	natural product fundamental parent			hp.json	natural product fundamental parents	http://purl.obolibrary.org/obo/CHEBI_35507		3_STAR
CHEBI:35509	biolink:ChemicalSubstance	androstane		CAS:24887-75-0|LIPID_MAPS_instance:LMST02020000|Beilstein:5247532	hp.json	androstane	http://purl.obolibrary.org/obo/CHEBI_35509		3_STAR
UBERON:0002150	biolink:AnatomicalEntity	superior cerebellar peduncle	A composite structure of the brain stem, which in NeuroNames is subdivided into the superior cerebellar peduncle of pons, the decussation of superior cerebellar peduncle and the superior cerebellar peduncle of midbrain (MM).	UMLS:C0152391|MA:0002746|BAMS:5|BM:BC|BAMS:scp|HBA:9297|DHBA:12354|MBA:326|DMBA:17793|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=1736|BIRNLEX:1711	hp.json	superior cerebelar peduncles|superior cerebellar peduncle (brachium conjunctivum)|pedunculus cerebellaris cranialis|superior peduncle|scp|superior cerebellar peduncle (Galen, Stilling)|brachium conjunctivum|pedunculus cerebellaris rostralis|tractus cerebello-rubralis|crus cerebello-cerebrale|superior cerebellar peduncle (brachium conjuctivum)|tractus cerebello-tegmentalis mesencephali|pedunculus cerebellaris superior	http://purl.obolibrary.org/obo/UBERON_0002150		uberon_slim|pheno_slim|human_reference_atlas
UBERON:0002152	biolink:AnatomicalEntity	middle cerebellar peduncle	Regional part of medullary white matter (according to Neuronames) primarily found at the level of the pons, consisting of a very large bundle of fibers originating in the pontine nuclei projecting to the cerebellum (MM).	MESH:D065837|BAMS:BP|BAMS:bp|DHBA:12768|MA:0002745|NIFSTD_RETIRED:birnlex_1699|MBA:78|FMA:72515|UMLS:C0152392|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=620|BIRNLEX:1529|BM:Pons-BP|HBA:9294|BAMS:mcp	hp.json	crus ponto-cerebellare|brachium pontis (stem of middle cerebellar peduncle)|pedunculus cerebellaris pontinus|pedunculus cerebellaris medialis|pedunculus cerebellaris medius|brachium pontis|mid-cerebellar peduncle|crus cerebelli ad pontem	http://purl.obolibrary.org/obo/UBERON_0002152		uberon_slim|pheno_slim|human_reference_atlas
GO:0140014	biolink:BiologicalProcess	mitotic nuclear division	A mitotic cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.		hp.json	mitosis	http://purl.obolibrary.org/obo/GO_0140014		goslim_generic|goslim_chembl
GO:0140013	biolink:BiologicalProcess	meiotic nuclear division	One of the two nuclear divisions that occur as part of the meiotic cell cycle.		hp.json	meiosis	http://purl.obolibrary.org/obo/GO_0140013		goslim_generic
UBERON:0002148	biolink:AnatomicalEntity	locus ceruleus	The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic[GO]. Bluish region in the superior angle of the fourth ventricle floor, corresponding to melanin-like pigmented nerve cells which lie lateral to the ponto-mesencephalic central gray (griseum centrale). It is also known as nucleus pigmentosus pontis[GAID].	DHBA:12819|MBA:147|ZFA:0000539|EMAPA:35502|MESH:D008125|TAO:0000539|BAMS:CAE|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=583|BM:Pons-LC|Wikipedia:Locus_ceruleus|BIRNLEX:905|GAID:577|HBA:9148|MA:0001017|BTO:0001408|UMLS:C0023951|DMBA:16972|UMLS:C0023951|NCIT:C97333|BAMS:LC|SCTID:369016004|FMA:72478|EFO:0001963	hp.json	locus coeruleus (Vicq d'Azyr)|substantia ferruginea|nucleus of locus caeruleus|caerulean nucleus|locus coeruleu|nucleus caeruleus|locus coeruleus|locus caeruleus|nucleus pigmentosus pontis|locus cinereus|blue nucleus|loci coeruleus|nucleus loci caerulei	http://purl.obolibrary.org/obo/UBERON_0002148		pheno_slim|efo_slim|uberon_slim|vertebrate_core
UBERON:0002149	biolink:AnatomicalEntity	superior salivatory nucleus	Nucleus containing parasympathetic neurons giving rise to the parasympathetic division of the facial nerve, innervating the salivary glands (Brodal, Neurological Anatomy, 3rd ed., 1981, pg 703).	BAMS:SSN|Wikipedia:Superior_salivatory_nucleus|HBA:9194|UMLS:C0175447|FMA:72482|MBA:462|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=590|MA:0001027|DHBA:12435|BAMS:SuS|BIRNLEX:1131|SCTID:369028007|EHDAA2:0004646|EMAPA:37756	hp.json	nucleus salivatorius superior|nucleus salivatorius rostralis|nucleus salivarius superior|superior salivary nucleus|nucleus salivatorius cranialis	http://purl.obolibrary.org/obo/UBERON_0002149		uberon_slim
UBERON:0002146	biolink:AnatomicalEntity	pulmonary valve	The semilunar valve of the heart that lies between the right ventricle and the pulmonary artery.	UMLS:C0034086|GAID:566|OpenCyc:Mx4rwP6uq5wpEbGdrcN5Y29ycA|FMA:7246|EMAPA:17872|galen:PulmonaryValve|NCIT:C12775|EHDAA2:0001577|VHOG:0000814|MESH:D011664|MA:0000089|EHDAA:4412	hp.json	valva trunci pulmonalis|pulmonic valve	http://purl.obolibrary.org/obo/UBERON_0002146		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0002129	biolink:AnatomicalEntity	cerebellar cortex	The superficial gray matter of the cerebellum. It consists of three main layers, the molecular layer, the Purkinje cell layer and the granule cell layer.	GAID:596|MBA:528|MESH:D002525|CALOHA:TS-2000|UMLS:C0007759|FMA:72248|MA:0000199|BM:CB-Cbx|UMLS:C0007759|UMLS:C1284087|BAMS:CbCx|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=647|NCIT:C49216|DMBA:16939|BAMS:CB|BAMS:CBX|EV:0100294|HBA:4697|VHOG:0001597|DHBA:10657|BTO:0000043|BIRNLEX:1566|EMAPA:35211	hp.json	cortex cerebellaris|cortex of cerebellar hemisphere|cortex cerebelli	http://purl.obolibrary.org/obo/UBERON_0002129		pheno_slim|human_reference_atlas|uberon_slim
UBERON:0004792	biolink:AnatomicalEntity	secretion of endocrine pancreas	A secretion that is part of a endocrine pancreas [Automatically generated definition].	UMLS:C1518866|MA:0002517|NCIT:C33255	hp.json	endocrine pancreas secretion|pars endocrina pancreatis secretion|pancreatic endocrine secretion|secretion of pars endocrina pancreatis	http://purl.obolibrary.org/obo/UBERON_0004792		
UBERON:0004793	biolink:AnatomicalEntity	secretion of exocrine pancreas	A secretion that is part of a exocrine pancreas [Automatically generated definition].	MA:0002518|UMLS:C1518867|NCIT:C33256	hp.json	pancreatic exocrine secretion|pars exocrina pancreatis secretion|exocrine pancreas secretion|secretion of pars exocrina pancreatis	http://purl.obolibrary.org/obo/UBERON_0004793		
UBERON:0004790	biolink:AnatomicalEntity	skin mucous gland	A mucous gland that is part of the skin.	EMAPA:35775|MA:0000148	hp.json	mucous gland of skin of body|mucous gland of entire skin|skin of body mucous gland|skin mucus gland	http://purl.obolibrary.org/obo/UBERON_0004790		organ_slim
UBERON:0002130	biolink:AnatomicalEntity	cerebellar nuclear complex	The gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei[MP].	BAMS:DNC|BIRNLEX:1568|UMLS:C0007763|MESH:D002529|GAID:599|MBA:519|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=682|BAMS:DCb|HBA:4780|FMA:72249|BAMS:CBN|BAMS:CBn|DHBA:10660|EV:0100299	hp.json	intrinsic nuclei of cerebellum|deep cerebellar nuclei|nuclei cerebelli|roof nuclei-2|deep cerebellar nuclear complex|nuclei cerebelli|central nuclei|nuclei cerebellares|intracerebellar nuclei|cerebellar nuclei|nuclei cerebellaris	http://purl.obolibrary.org/obo/UBERON_0002130		uberon_slim
UBERON:0004791	biolink:AnatomicalEntity	thymus trabecula	The thymic connective tissue which extends into the parenchyma.	UMLS:C1515431|MA:0002674|NCIT:C33773	hp.json	thymus gland trabecula|thymic trabecula|trabecula of thymus gland|trabecula of thymus|thymus trabeculae	http://purl.obolibrary.org/obo/UBERON_0004791		human_reference_atlas|pheno_slim
UBERON:0002137	biolink:AnatomicalEntity	aortic valve	Cardiac valve which has as its parts the anterior, right posterior and left posterior cusps, attached to the fibrous ring of aortic valve.[FMA].	MA:0000087|EHDAA2:0000134|EHDAA:4410|galen:AorticValve|NCIT:C12670|MESH:D001021|OpenCyc:Mx4rv5914JwpEbGdrcN5Y29ycA|FMA:7236|GAID:563|UMLS:C0003501|VHOG:0000815|BTO:0004628|EFO:0003879|EMAPA:17870	hp.json	valva aortae	http://purl.obolibrary.org/obo/UBERON_0002137		pheno_slim|efo_slim|human_reference_atlas|uberon_slim
CHEBI:23505	biolink:ChemicalSubstance	cystathionines			hp.json		http://purl.obolibrary.org/obo/CHEBI_23505		1_STAR
UBERON:0002133	biolink:AnatomicalEntity	atrioventricular valve	A cardial valve in the atrioventricular region that separates the atrium from the ventricle and prevent backflow from the ventricles into the atria during systole.	galen:AtrioventricularValve|EHDAA2:0000153|OpenCyc:Mx4rfCfdorrpEduAAAACs6hRXg|EHDAA:7421|ZFA:0005064|TAO:0005064|MA:0002789|EMAPA:35154|VHOG:0001472|FMA:7233	hp.json	atrio-ventricular valve|AV valve	http://purl.obolibrary.org/obo/UBERON_0002133		pheno_slim|vertebrate_core
UBERON:0004796	biolink:AnatomicalEntity	prostate gland secretion	A bodily secretion that is produced by the prostate gland.	FMA:66884|EMAPA:36545|MA:0002525|NCIT:C52553|UMLS:C1709733	hp.json	prostate fluid|secretion of prostate gland|secretion of prostate|prostatic fluid|prostate secretion	http://purl.obolibrary.org/obo/UBERON_0004796		
UBERON:0002132	biolink:AnatomicalEntity	dentate nucleus	The largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers.	HBA:12946|VHOG:0001700|BAMS:Dt|UMLS:C0086120|MA:0001008|FMA:72260|BAMS:DN|BM:CB-CBL|MBA:846|BTO:0003836|http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=683|EV:0100300|BIRNLEX:1171	hp.json	lateral cerebellar nucleus|dentate nucleus (Vicq d'Azyr)|dentate nucleus|lateral nucleus of cerebellum|nucleus dentatus cerebelli|nucleus lateralis cerebelli|nucleus dentatus|dentate cerebellar nucleus|dentatothalamocortical fibers|nucleus dentatus	http://purl.obolibrary.org/obo/UBERON_0002132		pheno_slim|uberon_slim
UBERON:0004797	biolink:AnatomicalEntity	blood vessel layer	Any of the tissue layers that comprise a blood vessel. Examples: tunica media, tunica adventitia.	MA:0002854|EMAPA:36296	hp.json		http://purl.obolibrary.org/obo/UBERON_0004797		
UBERON:0004794	biolink:AnatomicalEntity	esophagus secretion	A secretion that is part of a esophagus [Automatically generated definition].	UMLS:C0227179|MA:0002514|FMA:79662|NCIT:C52555	hp.json	oesophagus secretion|gullet secretion|secretion of oesophagus|secretion of gullet|secretion of esophagus|esophageal secretion	http://purl.obolibrary.org/obo/UBERON_0004794		
UBERON:0002135	biolink:AnatomicalEntity	mitral valve	An atrioventricular valve that is part of the outflow part of the left atrium.	MESH:D008943|OpenCyc:Mx4rv4l2nJwpEbGdrcN5Y29ycA|GAID:565|VHOG:0000817|FMA:7235|galen:MitralValve|EMAPA:17871|UMLS:C0026264|NCIT:C12753|EFO:0003933|MA:0000088|EHDAA2:0000168	hp.json	valva mitralis|valva atrioventricularis sinistra|left atrioventricular valve|bicuspid valve	http://purl.obolibrary.org/obo/UBERON_0002135		pheno_slim|efo_slim|human_reference_atlas|uberon_slim
UBERON:0004795	biolink:AnatomicalEntity	pancreas secretion	A secretion that is part of a pancreas [Automatically generated definition].	MA:0002516|NCIT:C13270|UMLS:C0030296	hp.json	pancreatic secretion|secretion of pancreas	http://purl.obolibrary.org/obo/UBERON_0004795		
CHEBI:23509	biolink:ChemicalSubstance	cysteine derivative	An amino acid derivative resulting from reaction of cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of cysteine by a heteroatom. The definition normally excludes peptides containing cysteine residues.		hp.json	cysteine derivatives|cysteine derivative	http://purl.obolibrary.org/obo/CHEBI_23509		3_STAR
UBERON:0002134	biolink:AnatomicalEntity	tricuspid valve	An atrioventricular valve that is part of the outflow part of the right atrium.	OpenCyc:Mx4rvuWAAJwpEbGdrcN5Y29ycA|RETIRED_EHDAA2:0002081|NCIT:C12805|MESH:D014261|MA:0000090|GAID:567|EMAPA:17873|UMLS:C0040960|VHOG:0000816|FMA:7234|EHDAA:7427|galen:TricuspidValve|EHDAA2:0004029	hp.json	right atrioventricular valve|valvula tricuspidalis|valva atrioventricularis dextra	http://purl.obolibrary.org/obo/UBERON_0002134		pheno_slim|human_reference_atlas|uberon_slim
CARO:0001001	biolink:NamedThing				Graph				
owl:Nothing	biolink:NamedThing				Graph